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Overview

ID MAG04067
Name TLS3_bin.8
Sample SMP0105
Taxonomy
Kingdom Archaea
Phylum Thermoproteota
Class Nitrososphaeria
Order Nitrososphaerales
Family Nitrososphaeraceae
Genus Nitrosocosmicus
Species
Assembly information
Completeness (%) 94.25
Contamination (%) 1.88
GC content (%) 34.0
N50 (bp) 9,071
Genome size (bp) 2,972,811

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2352

Gene name Description KEGG GOs EC E-value Score Sequence
TLS3_k127_1008898_0 SMC proteins Flexible Hinge Domain K03529 - - 1.732e-275 887.0
TLS3_k127_1008898_1 Belongs to the RtcB family K14415 - 6.5.1.3 5.615e-236 738.0
TLS3_k127_1008898_2 adenylosuccinate lyase K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 562.0
TLS3_k127_1008898_3 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 541.0
TLS3_k127_1008898_4 Belongs to the ABC transporter superfamily K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005158 275.0
TLS3_k127_1008898_5 hydrolase (HAD superfamily) K01091,K01560,K01561,K07025 - 3.1.3.18,3.8.1.2,3.8.1.3 0.000000000000000000000000000000000000000000000000006778 188.0
TLS3_k127_1008898_6 HIT domain K02503 - - 0.0000000000000000000000000000000005595 135.0
TLS3_k127_1008898_7 - - - - 0.000000000000000000000000000021 123.0
TLS3_k127_1008898_8 Helix-turn-helix domain - - - 0.00000000000000006429 87.0
TLS3_k127_1008898_9 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.000000000000718 69.0
TLS3_k127_1022305_0 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000004655 241.0
TLS3_k127_1022305_1 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000004806 207.0
TLS3_k127_1022305_10 PFAM transposase, IS4 family protein - - - 0.000000004663 68.0
TLS3_k127_1022305_11 Bacterial transferase hexapeptide (six repeats) K02617 - - 0.000008183 49.0
TLS3_k127_1022305_12 threonine-type endopeptidase activity K02737 GO:0000226,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005813,GO:0005815,GO:0005829,GO:0005839,GO:0005856,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007088,GO:0007098,GO:0007346,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009896,GO:0009987,GO:0010498,GO:0010499,GO:0010564,GO:0010638,GO:0010965,GO:0012505,GO:0015630,GO:0016020,GO:0016043,GO:0016579,GO:0016787,GO:0019538,GO:0019774,GO:0019941,GO:0022402,GO:0022607,GO:0030071,GO:0030163,GO:0031023,GO:0031331,GO:0031597,GO:0031974,GO:0031981,GO:0031984,GO:0032270,GO:0032436,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034515,GO:0034622,GO:0036211,GO:0042175,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043248,GO:0043412,GO:0043632,GO:0043687,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044430,GO:0044432,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045732,GO:0045787,GO:0045840,GO:0045842,GO:0045862,GO:0045931,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051247,GO:0051603,GO:0051726,GO:0051781,GO:0051783,GO:0051785,GO:0051983,GO:0051984,GO:0062033,GO:0065003,GO:0065007,GO:0070011,GO:0070013,GO:0070646,GO:0070647,GO:0071704,GO:0071840,GO:0080129,GO:0090068,GO:0098827,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901800,GO:1901970,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902099,GO:1902101,GO:1902494,GO:1903052,GO:1903364,GO:1905368,GO:1905369,GO:1905818,GO:1905820,GO:2001252 3.4.25.1 0.0005024 51.0
TLS3_k127_1022305_3 CHRD domain - - - 0.000000000000000000000009207 107.0
TLS3_k127_1022305_5 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000009303 98.0
TLS3_k127_1022305_7 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily K08698 - - 0.0000000000000002369 81.0
TLS3_k127_1022305_8 response regulator, receiver - - - 0.0000000000000004969 83.0
TLS3_k127_1022305_9 Transposase - - - 0.0000000000006958 70.0
TLS3_k127_1026979_0 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000000000001388 215.0
TLS3_k127_1026979_1 3-carboxymuconate cyclase K07404 - 3.1.1.31 0.00000000000000000000000000000000000000000000000001258 187.0
TLS3_k127_1028906_0 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000003312 121.0
TLS3_k127_103010_0 LOR SDH bifunctional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 609.0
TLS3_k127_103010_2 - - - - 0.0000000000000000000000000000000000001187 143.0
TLS3_k127_103010_3 HD domain K07023 - - 0.00000000000000000000000000008168 123.0
TLS3_k127_103010_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000005752 71.0
TLS3_k127_1031955_0 Belongs to the Dps family K04047 - - 0.000000000000000000000000000000003862 135.0
TLS3_k127_1040342_0 Alpha beta hydrolase - - - 0.0000000000000000000000000000000001182 138.0
TLS3_k127_1040342_1 Transposase DDE domain K07492 - - 0.00000000000000000000000000000006544 130.0
TLS3_k127_1040342_2 Putative transposase of IS4/5 family (DUF4096) - - - 0.000000000000000000001703 98.0
TLS3_k127_1040342_3 Alpha beta hydrolase - - - 0.000000000000000001499 89.0
TLS3_k127_1042426_0 Binding-protein-dependent transport system inner membrane component K02042 - - 0.00000000000000000000000000000000000000000000003237 179.0
TLS3_k127_1042426_1 PAC2 family K06869 - - 0.00000000000000000000000000000000000000000000205 174.0
TLS3_k127_1042426_10 Transposase and inactivated derivatives-like protein - - - 0.0001663 49.0
TLS3_k127_1042426_2 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000001846 171.0
TLS3_k127_1042426_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000001183 144.0
TLS3_k127_1042426_4 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000005346 130.0
TLS3_k127_1042426_5 CHRD domain - - - 0.00000000000000000000000009426 112.0
TLS3_k127_1042426_6 TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein K02044 - - 0.00000000000000003558 93.0
TLS3_k127_1042426_7 - - - - 0.0000000000004144 71.0
TLS3_k127_1042426_8 Transposase and inactivated derivatives K07494,K07499 - - 0.0000000008023 65.0
TLS3_k127_1042426_9 SPTR Transposase, IS4 family protein - - - 0.00001566 52.0
TLS3_k127_1045719_0 Bacterial transferase hexapeptide (six repeats) K02536 - 2.3.1.191 0.00000000000000000000000000008377 120.0
TLS3_k127_1045719_1 - - - - 0.0000000001269 64.0
TLS3_k127_1045719_2 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000002263 57.0
TLS3_k127_105524_0 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006664 448.0
TLS3_k127_105524_1 - - - - 0.00004878 52.0
TLS3_k127_1073030_0 thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 312.0
TLS3_k127_1073030_1 thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 298.0
TLS3_k127_1073030_2 phosphohistidine phosphatase, SixA K08296 - - 0.00000000000000000000000000000000001644 141.0
TLS3_k127_1075948_0 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000001497 85.0
TLS3_k127_1075948_2 Methyltransferase domain - - - 0.000001509 54.0
TLS3_k127_1075948_3 Universal stress protein - - - 0.000001612 50.0
TLS3_k127_1076027_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 2.362e-281 895.0
TLS3_k127_1076027_1 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 358.0
TLS3_k127_1076027_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00000000000000000000000004043 120.0
TLS3_k127_1076027_3 Universal stress protein - - - 0.000001612 50.0
TLS3_k127_1115031_0 this gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.000000000000000000000001531 109.0
TLS3_k127_1115031_1 PQ loop repeat K15383 - - 0.00000000001454 68.0
TLS3_k127_1115031_2 this gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.00000000009672 64.0
TLS3_k127_1115031_3 This gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.0000000002886 63.0
TLS3_k127_1115031_4 Transposase - - - 0.00006493 48.0
TLS3_k127_113248_0 Protein of unknown function DUF72 - - - 0.000006783 49.0
TLS3_k127_1135052_0 UbiD family decarboxylase K03182 - 4.1.1.98 3.143e-219 689.0
TLS3_k127_1135052_1 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009226 356.0
TLS3_k127_1135052_2 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 342.0
TLS3_k127_1135052_3 DHHA1 domain K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009141 303.0
TLS3_k127_1135052_4 Dual specificity phosphatase, catalytic domain K14165 - 3.1.3.16,3.1.3.48 0.00000000000000000000000000000000000000000000001124 176.0
TLS3_k127_1135052_5 - - - - 0.00000000000000000000000000000000000000000000001683 174.0
TLS3_k127_1135052_6 - - - - 0.000000000000000000007812 97.0
TLS3_k127_1135052_7 negative regulation of IRE1-mediated unfolded protein response K09515 GO:0001775,GO:0002376,GO:0002377,GO:0002440,GO:0002520,GO:0002521,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0006508,GO:0006511,GO:0006807,GO:0006950,GO:0006986,GO:0007154,GO:0007165,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0010646,GO:0010648,GO:0012505,GO:0016020,GO:0019538,GO:0019941,GO:0023051,GO:0023052,GO:0023057,GO:0030097,GO:0030098,GO:0030154,GO:0030163,GO:0030183,GO:0030433,GO:0030544,GO:0030968,GO:0031072,GO:0031974,GO:0031981,GO:0031984,GO:0032501,GO:0032502,GO:0033554,GO:0034620,GO:0034976,GO:0035966,GO:0035967,GO:0036498,GO:0036503,GO:0042113,GO:0042175,GO:0042221,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045321,GO:0046649,GO:0048513,GO:0048519,GO:0048523,GO:0048534,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051087,GO:0051603,GO:0051716,GO:0051787,GO:0065007,GO:0070013,GO:0070887,GO:0071310,GO:0071704,GO:0080134,GO:0080135,GO:0098827,GO:1900101,GO:1900102,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1903573,GO:1903894,GO:1903895,GO:1905897 - 0.000000000000000703 83.0
TLS3_k127_1135052_8 - - - - 0.000000000004275 70.0
TLS3_k127_114518_0 Reverse transcriptase (RNA-dependent DNA polymerase) K00699,K06515 - 2.4.1.17 5.671e-241 765.0
TLS3_k127_114930_0 tRNA pseudouridine synthase K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 392.0
TLS3_k127_114930_1 Copper resistance protein D - - - 0.0000000000000000000000000000000000000004614 154.0
TLS3_k127_114930_2 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000004422 143.0
TLS3_k127_114930_3 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000000000000000000000005925 136.0
TLS3_k127_114930_5 COG1522 Transcriptional regulators - - - 0.000000000000000000000000006521 115.0
TLS3_k127_114930_7 - - - - 0.00000000000000000007564 96.0
TLS3_k127_114930_8 Circadian clock protein KaiC K06945 - - 0.00000000000000002213 96.0
TLS3_k127_1192988_0 Alpha beta hydrolase - - - 0.000000000000000000000000001991 125.0
TLS3_k127_1193688_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000003601 209.0
TLS3_k127_1193688_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000000000000000000000000000000002336 134.0
TLS3_k127_1197936_0 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 415.0
TLS3_k127_1197936_1 Phosphomethylpyrimidine kinase K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006896 321.0
TLS3_k127_1197936_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000008428 240.0
TLS3_k127_1197936_3 Functions by promoting the formation of the first peptide bond K03263 - - 0.0000000000000000000000000000000000000000000000000000000103 199.0
TLS3_k127_1225419_0 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000002535 200.0
TLS3_k127_1225419_1 PFAM Calcineurin-like phosphoesterase - - - 0.000000001099 69.0
TLS3_k127_1242374_0 Trm112p-like protein - - - 0.00000000000000004331 86.0
TLS3_k127_1242374_1 PFAM blue (type 1) copper domain protein - - - 0.00000000001467 71.0
TLS3_k127_1242507_0 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000006807 246.0
TLS3_k127_1244738_0 PFAM Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 368.0
TLS3_k127_1244738_1 Thioredoxin K03671 - - 0.000000000000000000000000000000000004593 141.0
TLS3_k127_1244738_3 signal transduction protein with CBS domains - - - 0.00000000009521 74.0
TLS3_k127_1251095_0 Cupin domain - - - 0.00000000004744 70.0
TLS3_k127_1251095_1 IMP dehydrogenase activity - - - 0.000000004335 58.0
TLS3_k127_1251095_2 Antibiotic biosynthesis monooxygenase - - - 0.000003286 52.0
TLS3_k127_1251349_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 391.0
TLS3_k127_1251349_1 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 340.0
TLS3_k127_1251349_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000162 93.0
TLS3_k127_1251349_3 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.0000000000000001374 85.0
TLS3_k127_1251349_4 phosphorelay signal transduction system - - - 0.00000000000009416 76.0
TLS3_k127_1251349_5 PFAM TPR repeat-containing protein - - - 0.00000001202 59.0
TLS3_k127_126074_0 PFAM Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000001142 194.0
TLS3_k127_126074_1 EamA-like transporter family - - - 0.00000000000000000000000000001071 130.0
TLS3_k127_1270315_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002812 249.0
TLS3_k127_1270315_1 Large-conductance mechanosensitive channel, MscL K03282 - - 0.0000000000000000000000000000001359 127.0
TLS3_k127_1270315_2 - - - - 0.0004827 44.0
TLS3_k127_127861_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000002768 199.0
TLS3_k127_127861_1 ferredoxin - - - 0.000000000000000000000000000000000001383 138.0
TLS3_k127_1288236_0 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 349.0
TLS3_k127_1333519_0 - - - - 0.0000000000000000000000007198 115.0
TLS3_k127_1336408_0 Enoyl-(Acyl carrier protein) reductase - - - 4.088e-208 664.0
TLS3_k127_1336408_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 526.0
TLS3_k127_1336408_10 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000003851 146.0
TLS3_k127_1336408_11 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000000000000000000000004037 120.0
TLS3_k127_1336408_12 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.0000000000000000001616 89.0
TLS3_k127_1336408_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 441.0
TLS3_k127_1336408_3 TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 400.0
TLS3_k127_1336408_4 Phosphoglycolate phosphatase K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000046 264.0
TLS3_k127_1336408_5 membrane - - - 0.000000000000000000000000000000000000000000000000000000000003794 214.0
TLS3_k127_1336408_6 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000004219 212.0
TLS3_k127_1336408_7 - - - - 0.00000000000000000000000000000000000000000000000000000001725 204.0
TLS3_k127_1336408_8 phosphoribosylglycinamide formyltransferase K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000008438 198.0
TLS3_k127_1336408_9 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000003522 173.0
TLS3_k127_1356135_0 DEAD DEAH box helicase K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 389.0
TLS3_k127_1356135_1 elongation factor Tu - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009311 246.0
TLS3_k127_1356135_2 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000001334 211.0
TLS3_k127_1356135_4 - - - - 0.000000001144 68.0
TLS3_k127_1356865_0 Peptidase family M28 - - - 0.000000000000000000000000000000000000000004351 177.0
TLS3_k127_1358140_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 470.0
TLS3_k127_1366347_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 3.878e-213 686.0
TLS3_k127_1366347_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 415.0
TLS3_k127_1366347_10 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00000000000000000000001184 106.0
TLS3_k127_1366347_11 Glycosyltransferase Family 4 - - - 0.000000000000000000693 100.0
TLS3_k127_1366347_12 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00000000000000001408 90.0
TLS3_k127_1366347_13 CBS domain - - - 0.0000000000000001054 87.0
TLS3_k127_1366347_14 - - - - 0.0000000000003194 72.0
TLS3_k127_1366347_15 PFAM Alcohol dehydrogenase GroES-like domain K00001,K13953,K18382 - 1.1.1.1 0.000000000009055 66.0
TLS3_k127_1366347_16 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000000003376 68.0
TLS3_k127_1366347_17 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.0000000004574 61.0
TLS3_k127_1366347_18 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000000008955 64.0
TLS3_k127_1366347_19 PFAM Alcohol dehydrogenase GroES-like domain K00001,K13953,K18382 - 1.1.1.1 0.000000213 53.0
TLS3_k127_1366347_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 396.0
TLS3_k127_1366347_20 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.0000002969 55.0
TLS3_k127_1366347_3 Coenzyme A transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 328.0
TLS3_k127_1366347_4 beta-1,4-mannooligosaccharide phosphorylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001283 263.0
TLS3_k127_1366347_5 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004848 253.0
TLS3_k127_1366347_6 PFAM Alcohol dehydrogenase GroES-like domain K00001,K13953,K18382 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000001969 195.0
TLS3_k127_1366347_7 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000001241 191.0
TLS3_k127_1366347_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000002339 139.0
TLS3_k127_137241_0 DNA methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009133 457.0
TLS3_k127_137241_1 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 366.0
TLS3_k127_137241_2 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 317.0
TLS3_k127_137241_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 303.0
TLS3_k127_137241_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000007995 239.0
TLS3_k127_137241_5 GHMP kinases N terminal domain K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000003425 185.0
TLS3_k127_137241_6 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000001374 173.0
TLS3_k127_1372927_0 Major royal jelly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 598.0
TLS3_k127_1372927_1 PFAM PhoD-like phosphatase K01113 - 3.1.3.1 0.00002967 53.0
TLS3_k127_137311_0 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000008689 147.0
TLS3_k127_137311_1 transcriptional - - - 0.000000003527 61.0
TLS3_k127_1381081_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 7.763e-207 658.0
TLS3_k127_1381081_1 Histone acetyltransferase K07739 - 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000003649 259.0
TLS3_k127_1381081_2 - - - - 0.00000000000000000000000000004808 132.0
TLS3_k127_1413072_0 Protein of unknown function, DUF255 K06888 - - 2.377e-255 805.0
TLS3_k127_1413072_1 translation initiation inhibitor, yjgF family - - - 0.00000000000000000000000000000000000000000001859 167.0
TLS3_k127_1413072_3 - - - - 0.00000000000000000000002427 103.0
TLS3_k127_1413072_4 Multicopper oxidase K22349 - 1.16.3.3 0.00000000000000000741 92.0
TLS3_k127_1413072_6 Polysaccharide lyase - - - 0.0003354 48.0
TLS3_k127_1423382_0 DEAD DEAH box helicase domain protein K10896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001432 287.0
TLS3_k127_1427794_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005691 267.0
TLS3_k127_1428517_0 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000003898 82.0
TLS3_k127_1428517_1 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.0000000000002328 72.0
TLS3_k127_1458780_0 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 484.0
TLS3_k127_1458780_1 glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 390.0
TLS3_k127_1458780_10 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00007093 47.0
TLS3_k127_1458780_2 TIGRFAM daunorubicin resistance ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 343.0
TLS3_k127_1458780_3 Pfam:DUF377 K20885 - 2.4.1.339,2.4.1.340 0.00000000000000000000000000000000000000000000000000000000000000000000001502 253.0
TLS3_k127_1458780_4 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000001211 237.0
TLS3_k127_1458780_5 Glycosyltransferase Family 4 - - - 0.0000000000000000003302 101.0
TLS3_k127_1458780_6 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000000000000000007368 92.0
TLS3_k127_1458780_7 TRANSCRIPTIONal - - - 0.00000000000000001377 83.0
TLS3_k127_1462613_0 RNase L inhibitor, RLI K06174 - - 1.111e-280 873.0
TLS3_k127_1462613_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 1.64e-243 760.0
TLS3_k127_1462613_10 FR47-like protein K03789 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000000000000000000000002022 241.0
TLS3_k127_1462613_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000002223 232.0
TLS3_k127_1462613_12 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX K17759 - 5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000001487 221.0
TLS3_k127_1462613_13 PspA/IM30 family K03969 - - 0.000000000000000000000000000000000000000000000000000000000007049 214.0
TLS3_k127_1462613_14 Translin family K07477 - - 0.00000000000000000000000000000000000000000000004426 177.0
TLS3_k127_1462613_15 A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products - - - 0.00000000000000000000000000000000000000000000006157 173.0
TLS3_k127_1462613_17 - - - - 0.000000000000000002612 91.0
TLS3_k127_1462613_18 - - - - 0.000000000000008369 86.0
TLS3_k127_1462613_19 CHRD domain - - - 0.0000000000003315 72.0
TLS3_k127_1462613_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009006 409.0
TLS3_k127_1462613_20 PFAM regulatory protein TetR K03577,K18939 - - 0.0000000000007559 69.0
TLS3_k127_1462613_22 - - - - 0.000000000001965 76.0
TLS3_k127_1462613_23 Fibronectin type III domain K03933 - - 0.00000000004473 75.0
TLS3_k127_1462613_25 - - - - 0.0000000007199 64.0
TLS3_k127_1462613_26 Carboxymuconolactone decarboxylase family - - - 0.000000998 58.0
TLS3_k127_1462613_27 AAA ATPase domain - - - 0.000001046 54.0
TLS3_k127_1462613_28 CHRD domain - - - 0.0003133 43.0
TLS3_k127_1462613_3 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 380.0
TLS3_k127_1462613_4 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006563 372.0
TLS3_k127_1462613_5 Mg2 transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 348.0
TLS3_k127_1462613_6 Zn-dependent protease with chaperone function K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 345.0
TLS3_k127_1462613_7 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 346.0
TLS3_k127_1462613_8 Met-10+ like-protein K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007979 277.0
TLS3_k127_1462613_9 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003052 248.0
TLS3_k127_1511666_0 HEAT repeats K06072 - 1.14.99.29 0.000000000000000000000000000000000000000000000000331 182.0
TLS3_k127_1511666_1 SET domain K07117 - - 0.000000000000001006 81.0
TLS3_k127_1513167_0 HELICc2 - - - 0.000000000000000000000000000002455 128.0
TLS3_k127_15172_0 Chlorophyllase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000452 248.0
TLS3_k127_151837_0 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000006409 161.0
TLS3_k127_151837_1 pyridine nucleotide-disulfide oxidoreductase - - - 0.00000000000000000000000000000005643 138.0
TLS3_k127_151837_2 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000001545 130.0
TLS3_k127_151837_4 - - - - 0.0000000000002097 75.0
TLS3_k127_151837_5 ester cyclase - - - 0.00001183 49.0
TLS3_k127_1558933_1 Fungalysin metallopeptidase (M36) - - - 0.0001975 48.0
TLS3_k127_1568119_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 555.0
TLS3_k127_1568119_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002132 276.0
TLS3_k127_1568119_2 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000002721 211.0
TLS3_k127_1568119_3 - - - - 0.0000000002799 64.0
TLS3_k127_158109_0 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002326 259.0
TLS3_k127_158109_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000001799 123.0
TLS3_k127_1581369_0 COG0433 Predicted ATPase - - - 0.000000000000000000000000000000000000000000000006433 188.0
TLS3_k127_1581369_1 Na -dependent transporter K03453 - - 0.0000000000000000000000000000000000005005 146.0
TLS3_k127_1581369_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K04794 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.29 0.0000000000000000000000000001875 118.0
TLS3_k127_1581369_3 Protein of unknown function (DUF421) - - - 0.00000000000000000002682 101.0
TLS3_k127_158689_0 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007376 451.0
TLS3_k127_158689_1 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 391.0
TLS3_k127_16171_0 FeS assembly protein SufB K09014 - - 4.547e-287 884.0
TLS3_k127_16171_1 FeS assembly protein SufD K09014,K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 556.0
TLS3_k127_16171_10 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000007198 210.0
TLS3_k127_16171_11 Siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000000000000001553 175.0
TLS3_k127_16171_12 Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000203 172.0
TLS3_k127_16171_13 Cytochrome oxidase assembly protein K02259 - - 0.0000000000000000000000000000000000000000004511 162.0
TLS3_k127_16171_14 - - - - 0.00000000000000000000000000000000000003892 150.0
TLS3_k127_16171_15 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000000000006459 135.0
TLS3_k127_16171_16 RNA polymerase Rpb4 K03051 - 2.7.7.6 0.000000000000000000000000000001491 124.0
TLS3_k127_16171_17 of nitrite reductase and ring-hydroxylating K05710 - - 0.00000000000000000000002387 102.0
TLS3_k127_16171_18 PFAM blue (type 1) copper domain protein - - - 0.0000000000000007555 79.0
TLS3_k127_16171_2 PFAM aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 524.0
TLS3_k127_16171_20 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.000000001909 68.0
TLS3_k127_16171_21 Belongs to the UPF0235 family K09131 - - 0.000005947 51.0
TLS3_k127_16171_3 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 464.0
TLS3_k127_16171_4 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 391.0
TLS3_k127_16171_5 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 362.0
TLS3_k127_16171_6 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 360.0
TLS3_k127_16171_7 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 306.0
TLS3_k127_16171_8 Protein of unknown function (DUF655) K07572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005304 274.0
TLS3_k127_16171_9 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002337 278.0
TLS3_k127_1660113_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.345e-207 650.0
TLS3_k127_1660113_1 Luciferase-like monooxygenase K14728 - - 7.366e-204 637.0
TLS3_k127_1660113_10 LAO AO transport system ATPase K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 323.0
TLS3_k127_1660113_11 phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009508 294.0
TLS3_k127_1660113_12 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000005214 263.0
TLS3_k127_1660113_13 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000001413 243.0
TLS3_k127_1660113_15 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000000000001288 221.0
TLS3_k127_1660113_16 redox protein, regulator of disulfide bond formation - - - 0.00000000000000000000000000000002324 128.0
TLS3_k127_1660113_2 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 7.152e-203 638.0
TLS3_k127_1660113_3 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 5.154e-202 640.0
TLS3_k127_1660113_4 Cysteine synthase K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009111 492.0
TLS3_k127_1660113_5 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007437 486.0
TLS3_k127_1660113_6 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 486.0
TLS3_k127_1660113_7 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 438.0
TLS3_k127_1660113_8 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008755 423.0
TLS3_k127_1660113_9 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005233 346.0
TLS3_k127_1671435_0 Type III restriction enzyme, res subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 432.0
TLS3_k127_1671435_1 O-methyltransferase, family 2 K09846 - 2.1.1.210 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 346.0
TLS3_k127_1671435_2 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000003843 188.0
TLS3_k127_1671435_3 SPTR Transposase, IS4 family protein - - - 0.0000000000000000000002193 103.0
TLS3_k127_1689632_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 419.0
TLS3_k127_1689632_1 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 392.0
TLS3_k127_1689632_11 Methyltransferase type 11 K03183 - 2.1.1.163,2.1.1.201 0.0000000000000326 74.0
TLS3_k127_1689632_2 FAD linked - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 400.0
TLS3_k127_1689632_3 Located on the platform of the 30S subunit K02948 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000129 243.0
TLS3_k127_1689632_4 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000006065 243.0
TLS3_k127_1689632_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000006576 222.0
TLS3_k127_1689632_6 NADH ubiquinone oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000002996 213.0
TLS3_k127_1689632_7 Transcriptional regulator K07108 - - 0.000000000000000000000000000000000000000000000000000001969 194.0
TLS3_k127_1689632_8 Glyoxalase-like domain K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000003591 164.0
TLS3_k127_1689632_9 - - - - 0.0000000000000000000000000000000006399 131.0
TLS3_k127_1697457_0 PFAM beta-lactamase domain protein K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000000000000001506 266.0
TLS3_k127_1697457_1 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001133 231.0
TLS3_k127_1697457_2 - - - - 0.00000000000000000000000000000000004367 138.0
TLS3_k127_1697457_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000003828 102.0
TLS3_k127_1697457_4 - - - - 0.0001251 51.0
TLS3_k127_1703815_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 326.0
TLS3_k127_1703815_1 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000000000000008683 128.0
TLS3_k127_1703815_2 PFAM Integrase core domain K07497 - - 0.000000000000000000000000000004812 121.0
TLS3_k127_1703815_3 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000001043 74.0
TLS3_k127_1703815_4 COG3316 Transposase and inactivated derivatives K07498 - - 0.0006993 48.0
TLS3_k127_1709460_0 Phage integrase family - - - 0.00000000000000001005 96.0
TLS3_k127_171146_0 Pfam:Methyltransf_26 - - - 0.000000000000000000000000000000001302 133.0
TLS3_k127_171146_1 Glyoxalase-like domain K06996 - - 0.000000000000005557 78.0
TLS3_k127_171146_2 Histidine kinase - - - 0.0000006266 59.0
TLS3_k127_1728413_0 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 406.0
TLS3_k127_1728413_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002156 277.0
TLS3_k127_1728413_2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000001613 241.0
TLS3_k127_1728413_3 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000001151 218.0
TLS3_k127_1732238_0 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 293.0
TLS3_k127_1732238_1 Hep Hag repeat protein K09942,K21449 - - 0.0000001812 54.0
TLS3_k127_1751032_0 Sodium:neurotransmitter symporter family K03308 - - 0.000000000000000000000000000000000000000000000000000007887 199.0
TLS3_k127_1751032_1 NADH dehydrogenase K03885 GO:0003674,GO:0003824,GO:0003955,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0044237,GO:0045333,GO:0055114 1.6.99.3 0.00000000000000000000000000000000000000000000009101 184.0
TLS3_k127_1751032_2 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.0000000000000000000000000000000000000004123 156.0
TLS3_k127_1752529_0 - - - - 0.00000000000000000004929 94.0
TLS3_k127_1752529_1 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000001203 78.0
TLS3_k127_1753874_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 359.0
TLS3_k127_1753874_1 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 357.0
TLS3_k127_1753874_2 UreF K03188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001158 261.0
TLS3_k127_1753874_3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.0000000000000000000000000000000000000000000000000000007645 196.0
TLS3_k127_1753874_4 UreE urease accessory protein, N-terminal domain K03187 - - 0.0000000000000000000000000000000000000001931 156.0
TLS3_k127_1754371_0 this gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.00000000000000003365 87.0
TLS3_k127_1754371_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.00000111 51.0
TLS3_k127_1756197_0 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 595.0
TLS3_k127_1756197_1 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000007251 261.0
TLS3_k127_1759347_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 487.0
TLS3_k127_1759347_1 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000535 460.0
TLS3_k127_1759347_10 - - - - 0.000000000000000000000000000000000000000000002532 173.0
TLS3_k127_1759347_11 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.00000000000000000000000000000000000151 138.0
TLS3_k127_1759347_12 response regulator, receiver - - - 0.0000000000000000000004713 100.0
TLS3_k127_1759347_13 Transcriptional regulatory protein, C terminal K20488 - - 0.00000000000002852 78.0
TLS3_k127_1759347_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 424.0
TLS3_k127_1759347_3 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000259 375.0
TLS3_k127_1759347_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003635 359.0
TLS3_k127_1759347_5 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 329.0
TLS3_k127_1759347_6 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009644 269.0
TLS3_k127_1759347_7 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001235 279.0
TLS3_k127_1759347_8 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000007963 259.0
TLS3_k127_1759347_9 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000006843 238.0
TLS3_k127_1768090_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004616 582.0
TLS3_k127_1768090_1 CAAX protease self-immunity - - - 0.0000000000000000000000000000008595 134.0
TLS3_k127_1768090_2 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000003926 120.0
TLS3_k127_1806789_0 Helix-turn-helix of DDE superfamily endonuclease - - - 0.0000000001541 71.0
TLS3_k127_1830954_0 Methionine synthase K00548 - 2.1.1.13 0.0 1058.0
TLS3_k127_1830954_1 homocysteine S-methyltransferase K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 409.0
TLS3_k127_1830954_10 - - - - 0.0000000000000000002438 90.0
TLS3_k127_1830954_2 PFAM Glycosyl transferase family 2 K00752 - 2.4.1.212 0.00000000000000000000000000000000000000000000000000000000000000000000000002233 268.0
TLS3_k127_1830954_3 ATP-grasp domain K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000000000001787 196.0
TLS3_k127_1830954_4 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000006918 187.0
TLS3_k127_1830954_5 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000001493 176.0
TLS3_k127_1830954_6 ATP-grasp domain K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000078 173.0
TLS3_k127_1830954_7 WbqC-like protein family - - - 0.00000000000000000000000000000002126 144.0
TLS3_k127_1830954_8 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.000000000000000000004283 96.0
TLS3_k127_1830954_9 Histidinol phosphatase and related hydrolases of the PHP family K04477 - - 0.0000000000000000002229 96.0
TLS3_k127_1842465_0 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03635,K03637 - 2.8.1.12,4.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 298.0
TLS3_k127_1842465_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 299.0
TLS3_k127_1842465_2 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000276 270.0
TLS3_k127_1842465_3 Mo-co oxidoreductase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002527 268.0
TLS3_k127_1842465_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000003354 223.0
TLS3_k127_1842465_5 PFAM MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000388 188.0
TLS3_k127_1842465_6 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000008765 132.0
TLS3_k127_1842465_7 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.00000000000000000000002322 106.0
TLS3_k127_1842465_8 ThiS family K03636 - - 0.00000002863 58.0
TLS3_k127_185997_0 Uncharacterised BCR, YnfA/UPF0060 family K09771 - - 0.0000000000000000000000000000000000000000000000005139 177.0
TLS3_k127_185997_1 Uncharacterised BCR, YnfA/UPF0060 family K09771 - - 0.0000000000000000000000000000000000000000005887 160.0
TLS3_k127_185997_2 PAS fold - - - 0.000000000000006721 80.0
TLS3_k127_1882166_0 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000006892 226.0
TLS3_k127_1882166_1 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000005295 205.0
TLS3_k127_1882166_2 TspO/MBR family K05770 GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - 0.0000000000000000000000000000000000000000006934 161.0
TLS3_k127_1890432_0 Probable cobalt transporter subunit (CbtA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001253 246.0
TLS3_k127_1890432_1 Domain of unknown function (DUF4443) - - - 0.00000000000000000000000000000000000000000000000000000000004219 212.0
TLS3_k127_1890432_11 COG3415 Transposase and inactivated derivatives - - - 0.0009325 46.0
TLS3_k127_1890432_2 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.000000000000000000000000000000000000000006096 158.0
TLS3_k127_1890432_3 Peptidase family M23 - - - 0.0000000000000000000005382 101.0
TLS3_k127_1890432_4 Probable cobalt transporter subunit (CbtB) - - - 0.000000000000001822 79.0
TLS3_k127_1890432_5 Transposase and inactivated derivatives K07494,K07499 - - 0.000000001412 61.0
TLS3_k127_1890432_6 COG3316 Transposase and inactivated derivatives K07498 - - 0.00000002423 58.0
TLS3_k127_1890432_9 COGs COG3415 Transposase and inactivated derivatives K07499 - - 0.00002591 50.0
TLS3_k127_1906862_0 SNARE associated Golgi protein K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.00000000000000000000002165 106.0
TLS3_k127_1906862_2 zinc transporter K07238 - - 0.0000000000003264 80.0
TLS3_k127_1909760_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 453.0
TLS3_k127_1909760_1 TIGRFAM luciferase family oxidoreductase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009269 442.0
TLS3_k127_1909760_10 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000002666 59.0
TLS3_k127_1909760_11 PFAM blue (type 1) copper domain protein - - - 0.0000001494 56.0
TLS3_k127_1909760_12 PFAM Radical SAM domain protein - - - 0.00000606 50.0
TLS3_k127_1909760_2 Putative lumazine-binding - - - 0.000000000000000000000000000000000000000000000000005027 184.0
TLS3_k127_1909760_3 phosphoribosyltransferase K07101 - - 0.000000000000000000000000000000000000004846 151.0
TLS3_k127_1909760_4 - - - - 0.0000000000000000000000000000000002953 135.0
TLS3_k127_1909760_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000836 130.0
TLS3_k127_1909760_6 Belongs to the PdaD family K02626 - 4.1.1.19 0.000000000000000000000000000002412 119.0
TLS3_k127_1909760_7 PFAM Radical SAM domain protein - - - 0.000000000000005631 78.0
TLS3_k127_1909760_8 PFAM Radical SAM domain protein - - - 0.00000000000001925 76.0
TLS3_k127_1909760_9 Archaeal TRASH domain - - - 0.000000000004646 68.0
TLS3_k127_1909861_0 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 327.0
TLS3_k127_1909861_1 metal-binding integral membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 310.0
TLS3_k127_1909861_2 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005223 280.0
TLS3_k127_1909861_3 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000003072 166.0
TLS3_k127_1909861_4 PFAM Cupin 2, conserved barrel domain protein K11312 - - 0.0000000000000000000000000000000000000000001214 162.0
TLS3_k127_1909861_5 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000002425 142.0
TLS3_k127_1909861_6 amine dehydrogenase activity - - - 0.000000000000000009357 86.0
TLS3_k127_1909861_7 amine dehydrogenase activity - - - 0.0000000000001261 74.0
TLS3_k127_1909861_8 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000009685 55.0
TLS3_k127_1918282_1 FG-GAP repeat - - - 0.000000005181 59.0
TLS3_k127_1928436_0 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 324.0
TLS3_k127_1928436_1 carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000003107 177.0
TLS3_k127_1955412_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1036.0
TLS3_k127_1955412_1 Domain of unknown function (DUF1297) K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 496.0
TLS3_k127_1955412_2 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 426.0
TLS3_k127_1955412_3 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005536 308.0
TLS3_k127_1955412_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000006162 240.0
TLS3_k127_1955412_5 thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000001265 180.0
TLS3_k127_1955412_6 mttA/Hcf106 family K03116 - - 0.000000000000000000008013 98.0
TLS3_k127_1955412_7 - - - - 0.0000000000002245 74.0
TLS3_k127_1957385_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1062.0
TLS3_k127_1957385_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 455.0
TLS3_k127_1957385_2 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000132 231.0
TLS3_k127_1957385_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000003884 164.0
TLS3_k127_1957385_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000009024 72.0
TLS3_k127_1957385_5 PFAM beta-lactamase domain protein K06897 - 2.5.1.105 0.000000001593 59.0
TLS3_k127_1957477_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 1.559e-219 696.0
TLS3_k127_1957477_1 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 368.0
TLS3_k127_1957477_2 COG1233 Phytoene dehydrogenase and related proteins K10254 - 4.2.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 358.0
TLS3_k127_1957477_3 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.0000000000000000000000000000000001592 134.0
TLS3_k127_1957477_4 PFAM regulatory protein TetR K03577,K18939 - - 0.000000000000000000000000000000006089 135.0
TLS3_k127_1957477_5 - - - - 0.000000000000000000001683 95.0
TLS3_k127_1957477_6 amine dehydrogenase activity - - - 0.000000000000006144 76.0
TLS3_k127_1957477_7 PFAM beta-lactamase domain protein K06897 - 2.5.1.105 0.000000001593 59.0
TLS3_k127_1964098_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 423.0
TLS3_k127_1964098_1 Belongs to the universal ribosomal protein uS5 family K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 332.0
TLS3_k127_1964098_2 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000001988 256.0
TLS3_k127_1964098_3 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000005201 231.0
TLS3_k127_1964098_4 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000000000000000000000001371 208.0
TLS3_k127_1964098_5 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000006016 184.0
TLS3_k127_1964098_6 ribosomal protein K02907 - - 0.000000000000000000000000000000000000000000000215 172.0
TLS3_k127_1964098_7 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000002489 71.0
TLS3_k127_1983722_0 - - - - 0.00000000000000007864 89.0
TLS3_k127_1983722_1 response regulator, receiver K02490 - - 0.0000000000001654 76.0
TLS3_k127_1983722_2 Zinc-binding dehydrogenase K12957 - - 0.0000000003031 60.0
TLS3_k127_2005116_0 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000000000000103 166.0
TLS3_k127_2005116_1 Universal stress protein - - - 0.000000000000000000000000000000008589 132.0
TLS3_k127_2005116_2 Required for chromosome condensation and partitioning - - - 0.000000000000000000000000000002066 136.0
TLS3_k127_2005116_3 Belongs to the enoyl-CoA hydratase isomerase family K15019 - 4.2.1.116 0.0000000000000000000000000001883 117.0
TLS3_k127_2005116_4 - - - - 0.00000000466 61.0
TLS3_k127_2005116_5 Enoyl-CoA hydratase/isomerase K07534 - - 0.000025 48.0
TLS3_k127_2005116_6 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00003488 50.0
TLS3_k127_2008641_0 Staphylococcal nuclease homologue - - - 0.0000000000000001087 89.0
TLS3_k127_2040016_0 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000009347 211.0
TLS3_k127_2040016_1 - - - - 0.000000000002248 69.0
TLS3_k127_2043619_1 - - - - 0.00000000000005362 72.0
TLS3_k127_2043619_2 COG1522 Transcriptional regulators - - - 0.000000000002147 69.0
TLS3_k127_2077466_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 2.079e-229 735.0
TLS3_k127_2077466_1 Initiation factor K03242 - - 1.035e-203 640.0
TLS3_k127_2077466_2 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 2.391e-197 619.0
TLS3_k127_2077466_3 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000003789 271.0
TLS3_k127_2077466_4 NAD(P)H-dependent FMN reductase K00299 - 1.5.1.38 0.000000000000000000000000000000000000000000000000000000004638 205.0
TLS3_k127_2077466_5 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.00000000000000000000000000000000000000000001458 165.0
TLS3_k127_2077466_6 Nucleotide binding protein, PINc K07158 - - 0.00000000000003962 78.0
TLS3_k127_2077466_8 - - - - 0.00000000502 59.0
TLS3_k127_2078537_0 HELICc2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 399.0
TLS3_k127_2082840_0 CBS domain - - - 0.00000000000000000000002394 105.0
TLS3_k127_2082840_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K03294,K20989 - - 0.0000000000000000002874 93.0
TLS3_k127_2082840_2 Transposase - - - 0.000000000006664 68.0
TLS3_k127_2082840_3 Helix-turn-helix of DDE superfamily endonuclease - - - 0.0002535 46.0
TLS3_k127_2085274_0 COG3547 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000004684 183.0
TLS3_k127_2085274_1 SPTR Transposase, IS4 family protein - - - 0.00000000000000000001676 97.0
TLS3_k127_2085274_2 SPTR Transposase, IS4 family protein - - - 0.000000000000000115 82.0
TLS3_k127_2085274_3 SPTR Transposase, IS4 family protein - - - 0.0000532 49.0
TLS3_k127_2103556_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 555.0
TLS3_k127_2103556_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 522.0
TLS3_k127_2103556_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 458.0
TLS3_k127_2103556_3 ABC-type transport system, involved in lipoprotein release, permease component K02004 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 430.0
TLS3_k127_2103556_4 ABC-type antimicrobial peptide transport system, ATPase component K02003,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 326.0
TLS3_k127_2103556_5 extracellular matrix structural constituent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008819 283.0
TLS3_k127_2103556_6 Hint domain - - - 0.00000000000000000001513 100.0
TLS3_k127_2136421_0 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004722 225.0
TLS3_k127_2136421_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000007645 239.0
TLS3_k127_2136421_2 Hemerythrin HHE cation binding - - - 0.000000000000000000000000000000000000000000000000000003777 195.0
TLS3_k127_2136421_3 Pfam:KaiC K08482 - - 0.00000000000000000000000000000000000000000000000002209 197.0
TLS3_k127_2136421_4 SPTR Transposase, IS4 family protein - - - 0.00000000000000000000000000000001153 131.0
TLS3_k127_2136421_5 Circadian clock protein KaiC - - - 0.0000000000000007239 85.0
TLS3_k127_2136421_6 His Kinase A (phosphoacceptor) domain - - - 0.0000000000002715 74.0
TLS3_k127_2136920_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 9.026e-273 857.0
TLS3_k127_2136920_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 6.606e-225 705.0
TLS3_k127_2136920_10 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004099 276.0
TLS3_k127_2136920_11 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K02823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002643 264.0
TLS3_k127_2136920_12 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000004786 244.0
TLS3_k127_2136920_13 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000001481 238.0
TLS3_k127_2136920_14 segregation and condensation protein K06024 - - 0.00000000000000000000000000000000000000000000000000000000000002229 218.0
TLS3_k127_2136920_15 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000005422 213.0
TLS3_k127_2136920_16 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.000000000000000000000000000000000000000000000000000000000008894 214.0
TLS3_k127_2136920_17 chromosome segregation and condensation protein ScpA K05896 - - 0.00000000000000000000000000000000000000000000000000000006089 205.0
TLS3_k127_2136920_18 Ribosomal protein S8e K02995 - - 0.000000000000000000000000000000000000000000000000167 179.0
TLS3_k127_2136920_19 - - - - 0.0000000000000000000000000000000000001942 143.0
TLS3_k127_2136920_2 DNA Topoisomerase I (eukaryota) K03163 - 5.99.1.2 3.729e-205 653.0
TLS3_k127_2136920_20 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000456 119.0
TLS3_k127_2136920_21 Phosphomethylpyrimidine kinase K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.000000000000000000000002114 106.0
TLS3_k127_2136920_22 Nudix hydrolase K03574 - 3.6.1.55 0.00000000001822 70.0
TLS3_k127_2136920_3 Radical SAM K11781 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 551.0
TLS3_k127_2136920_4 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000689 517.0
TLS3_k127_2136920_5 Chorismate mutase type II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 415.0
TLS3_k127_2136920_6 Radical SAM K11780 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 347.0
TLS3_k127_2136920_7 Nucleotidyl transferase K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003788 329.0
TLS3_k127_2136920_8 Catalyzes the conversion of dihydroorotate to orotate K00226,K00254,K17723,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 314.0
TLS3_k127_2136920_9 Cob(II)yrinic acid a,c-diamide reductase K04719 - 1.13.11.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005851 293.0
TLS3_k127_2150729_0 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000006604 121.0
TLS3_k127_2150729_1 - - - - 0.00000000000000000000000000003373 128.0
TLS3_k127_2150729_2 - - - - 0.000000000000001213 79.0
TLS3_k127_2181443_0 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000005314 194.0
TLS3_k127_2181443_1 KR domain - - - 0.00000000000000000000000000000000000000000000558 172.0
TLS3_k127_2181443_2 PFAM Methyltransferase type K15256 - - 0.0000000000000000000000000000000000009018 146.0
TLS3_k127_2181443_3 Hemerythrin HHE cation binding domain - - - 0.00000000000000000007466 91.0
TLS3_k127_2193066_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 2.794e-232 733.0
TLS3_k127_2193066_1 PFAM tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 503.0
TLS3_k127_2193066_10 PFAM Protein kinase domain - - - 0.0000000006923 70.0
TLS3_k127_2193066_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 364.0
TLS3_k127_2193066_3 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001826 255.0
TLS3_k127_2193066_4 glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000001845 205.0
TLS3_k127_2193066_5 nicotinamide-nucleotide adenylyltransferase K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000002021 167.0
TLS3_k127_2193066_6 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K00363,K15762 - 1.7.1.15 0.00000000000000000000000000000000000000000009175 160.0
TLS3_k127_2193066_8 Transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.0000000000000000000006995 107.0
TLS3_k127_2193066_9 PFAM Protein kinase domain - - - 0.0000000001624 67.0
TLS3_k127_2196664_0 AsnC-type helix-turn-helix domain - - - 0.0000000000000000000000000000000006357 142.0
TLS3_k127_2196664_2 This gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.0000000000005533 69.0
TLS3_k127_2196664_3 Peptidyl-tRNA hydrolase K04794 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0010941,GO:0010942,GO:0016787,GO:0016788,GO:0019222,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0052689,GO:0060255,GO:0060548,GO:0065007,GO:0140098,GO:0140101,GO:2000209,GO:2000210,GO:2000811 3.1.1.29 0.0000000009961 64.0
TLS3_k127_2196664_4 Multicopper - - - 0.000000002268 61.0
TLS3_k127_2196664_6 cytochrome - - - 0.000000009253 64.0
TLS3_k127_2196664_8 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00025 45.0
TLS3_k127_2224139_0 GXWXG protein - - - 0.000000000000000000000000000000000000000000000000008189 184.0
TLS3_k127_2224139_1 HNH endonuclease - - - 0.000000000006424 75.0
TLS3_k127_2251913_0 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 370.0
TLS3_k127_2251913_1 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 302.0
TLS3_k127_2251913_2 - - - - 0.0000000000000000000000000000000000000000001204 164.0
TLS3_k127_2251913_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.00000000000000000000000000000000001721 138.0
TLS3_k127_226481_0 Alpha beta hydrolase K01066,K14731 - 3.1.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 401.0
TLS3_k127_226481_1 Pkd domain containing protein - - - 0.0000000000000000000002849 107.0
TLS3_k127_226512_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000007672 152.0
TLS3_k127_2284141_0 COG0520 Selenocysteine lyase K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 432.0
TLS3_k127_2284141_1 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 334.0
TLS3_k127_2284141_2 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002063 282.0
TLS3_k127_2284141_3 SUF system FeS assembly protein K04488 - - 0.0000000000000000000000000000000000000000000000000000000000000000003048 231.0
TLS3_k127_2284141_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000001451 159.0
TLS3_k127_2284141_5 Transcription elongation factor - - - 0.0000000000000000000000000000000000008248 145.0
TLS3_k127_2284141_6 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000002057 135.0
TLS3_k127_2284141_7 - - - - 0.00000000004981 67.0
TLS3_k127_2308008_0 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006542 552.0
TLS3_k127_2308008_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000003137 166.0
TLS3_k127_2308008_3 conserved protein (DUF2196) - - - 0.00000000000000000006856 91.0
TLS3_k127_2308008_4 PFAM CBS domain containing protein - - - 0.000000000000611 76.0
TLS3_k127_2315751_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 1.761e-227 709.0
TLS3_k127_2315751_1 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 479.0
TLS3_k127_2315751_2 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 476.0
TLS3_k127_2315751_3 FeS assembly ATPase SufC K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 411.0
TLS3_k127_2315751_4 Chlorite dismutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 322.0
TLS3_k127_2315751_5 Domain of unknown function (DUF1802) - - - 0.000000000000000000000000000000000000000000001783 176.0
TLS3_k127_2315751_6 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000001966 129.0
TLS3_k127_2315751_7 protein conserved in archaea K09723 - - 0.000000000000000000000000003706 118.0
TLS3_k127_2315751_8 - - - - 0.0000001449 55.0
TLS3_k127_2321382_0 Protein of unknown function (DUF4256) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 298.0
TLS3_k127_2321382_1 - - - - 0.0000000000000000000000000000000000001952 146.0
TLS3_k127_2321382_2 - - - - 0.00000000000000000000000000000000001533 145.0
TLS3_k127_2321382_3 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000008727 99.0
TLS3_k127_2327102_0 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000007063 246.0
TLS3_k127_2334184_0 inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 386.0
TLS3_k127_2334184_1 inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 320.0
TLS3_k127_2334184_2 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.0000000000000000000000000000000000000004832 153.0
TLS3_k127_2337134_0 transposition, RNA-mediated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 581.0
TLS3_k127_2342622_0 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001679 267.0
TLS3_k127_2342622_1 Belongs to the Dps family K04047 - - 0.000000000000000000000000000000000000000000000000000501 188.0
TLS3_k127_2342622_10 SnoaL-like domain - - - 0.000002443 50.0
TLS3_k127_2342622_11 PFAM Integrase catalytic region - - - 0.00003488 53.0
TLS3_k127_2342622_12 PFAM Transposase - - - 0.00004144 52.0
TLS3_k127_2342622_13 Transposase - - - 0.0007876 47.0
TLS3_k127_2342622_2 PFAM Nucleotidyl transferase K00966,K03430 - 2.6.1.37,2.7.7.13 0.000000000000000000000000000000000000000000000000002521 192.0
TLS3_k127_2342622_3 Ketosteroid isomerase-related protein - - - 0.0000000000000001544 81.0
TLS3_k127_2342622_5 Transcriptional regulatory protein, C terminal K14983 - - 0.000000000002156 72.0
TLS3_k127_2342622_7 Protein of unknown function (DUF1059) - - - 0.00000001108 57.0
TLS3_k127_2342622_8 Transcriptional regulatory protein, C terminal - - - 0.0000003589 57.0
TLS3_k127_2342622_9 OsmC-like protein - - - 0.0000007814 57.0
TLS3_k127_2346722_0 Putative esterase - - - 0.000001756 53.0
TLS3_k127_239708_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 550.0
TLS3_k127_239708_1 ATP-grasp domain K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 493.0
TLS3_k127_239708_10 Protein of unknown function (DUF424) K09148 - - 0.00000000000000000004642 93.0
TLS3_k127_239708_11 transcription factor (CBF NF-Y) - - - 0.0000000000000000241 83.0
TLS3_k127_239708_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 473.0
TLS3_k127_239708_3 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000121 210.0
TLS3_k127_239708_4 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000164 194.0
TLS3_k127_239708_5 - - - - 0.00000000000000000000000000000000000000000000001862 179.0
TLS3_k127_239708_6 - - - - 0.000000000000000000000000000000000000000000003184 171.0
TLS3_k127_239708_7 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000001918 162.0
TLS3_k127_239708_8 Domain of unknown function (DUF309) K09763 - - 0.0000000000000000000000000006068 120.0
TLS3_k127_239708_9 Domain of unknown function (DUF373) K08975 - - 0.0000000000000000000000007349 106.0
TLS3_k127_2404798_0 - - - - 0.00000000000000000000000000000000000339 140.0
TLS3_k127_2423785_0 Transposase and inactivated derivatives - - - 0.000000006119 60.0
TLS3_k127_2423785_1 - - - - 0.0000004119 54.0
TLS3_k127_2423785_2 Transposase DDE domain - - - 0.00005684 46.0
TLS3_k127_2427878_0 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000003966 234.0
TLS3_k127_2427878_1 - - - - 0.000000000000000000000000000003556 120.0
TLS3_k127_2427878_2 - - - - 0.00000000000000001831 88.0
TLS3_k127_2427878_3 Methyltransferase type 11 - - - 0.0000001912 55.0
TLS3_k127_2436165_0 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 362.0
TLS3_k127_2436165_1 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000009991 166.0
TLS3_k127_2436165_2 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000001429 157.0
TLS3_k127_2436165_4 This gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.000001116 53.0
TLS3_k127_2436165_5 - - - - 0.00003086 53.0
TLS3_k127_243641_0 - - - - 0.0000000000000000000000000000000000000000000000000000000002082 209.0
TLS3_k127_243641_1 - - - - 0.0000000000000000000000000000000000002071 141.0
TLS3_k127_243641_2 - - - - 0.000000000000000000002057 97.0
TLS3_k127_243641_3 DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000004266 70.0
TLS3_k127_243641_4 H subunit K02107 - - 0.00004165 46.0
TLS3_k127_2490487_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 341.0
TLS3_k127_2498244_0 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 1.839e-226 707.0
TLS3_k127_2498244_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009914 518.0
TLS3_k127_2507896_0 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000001662 159.0
TLS3_k127_2507896_1 chorismate mutase K04782 - 4.2.99.21 0.0000000000000001001 83.0
TLS3_k127_2518051_0 gag-polypeptide of LTR copia-type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006114 372.0
TLS3_k127_2518051_1 DNA RNA polymerases superfamily protein - - - 0.0000000000000000000000000000000000000000000000000000001147 216.0
TLS3_k127_2544527_0 Diphthamide biosynthesis K07561 - 2.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 473.0
TLS3_k127_2544527_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 292.0
TLS3_k127_2544527_10 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000002634 99.0
TLS3_k127_2544527_12 - - - - 0.000000000000001677 82.0
TLS3_k127_2544527_2 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 289.0
TLS3_k127_2544527_3 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006877 278.0
TLS3_k127_2544527_4 Pterin binding enzyme K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000003498 247.0
TLS3_k127_2544527_5 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000195 232.0
TLS3_k127_2544527_6 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000000000000001583 198.0
TLS3_k127_2544527_7 - - - - 0.00000000000000000000000000000000003859 139.0
TLS3_k127_2544527_8 - - - - 0.00000000000000000000000000000001123 131.0
TLS3_k127_2544527_9 - - - - 0.0000000000000000000000006452 112.0
TLS3_k127_257958_0 DEAD/H associated K03724 - - 0.0 1073.0
TLS3_k127_257958_1 Aminotransferase class-V - - - 9.639e-196 615.0
TLS3_k127_257958_10 antibiotic catabolic process K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 314.0
TLS3_k127_257958_11 Belongs to the peptidase M24B family K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 301.0
TLS3_k127_257958_12 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002613 255.0
TLS3_k127_257958_13 Pfam:DUF552 K09152 - - 0.00000000000000000000000001805 111.0
TLS3_k127_257958_14 RNA-binding protein contains TRAM domain - - - 0.000000000000000003556 88.0
TLS3_k127_257958_15 RNA binding K07581 - - 0.000000000005531 71.0
TLS3_k127_257958_2 RNA-metabolising metallo-beta-lactamase K07041 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 583.0
TLS3_k127_257958_3 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 477.0
TLS3_k127_257958_4 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 451.0
TLS3_k127_257958_5 Thiamine biosynthesis protein (ThiI) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005376 414.0
TLS3_k127_257958_6 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 391.0
TLS3_k127_257958_7 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 371.0
TLS3_k127_257958_8 COG0530 Ca2 Na antiporter K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 320.0
TLS3_k127_257958_9 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 308.0
TLS3_k127_2587336_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 454.0
TLS3_k127_2587336_1 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001233 274.0
TLS3_k127_2587336_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000002412 252.0
TLS3_k127_2587336_3 RibD C-terminal domain K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000001241 194.0
TLS3_k127_2587336_4 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000002059 172.0
TLS3_k127_2587336_5 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000002661 138.0
TLS3_k127_2587336_6 - - - - 0.00000000000000000000000000000000799 130.0
TLS3_k127_2587336_7 - - - - 0.0000000000000000000000000000001634 127.0
TLS3_k127_2587336_8 - - - - 0.000000000000000009072 93.0
TLS3_k127_2610563_0 - - - - 0.00000000000000000000000000000000000000000000000000000000001292 224.0
TLS3_k127_2610563_1 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000001045 181.0
TLS3_k127_2610563_2 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000172 169.0
TLS3_k127_2610563_3 PFAM phosphoesterase, PA-phosphatase related K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.000000000000000000000006943 110.0
TLS3_k127_2610563_4 Multicopper oxidase K22349 - 1.16.3.3 0.00000000000000000001282 93.0
TLS3_k127_2610563_5 Multicopper - - - 0.000009598 50.0
TLS3_k127_2611423_0 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 348.0
TLS3_k127_2611423_1 - - - - 0.0000000000000000000000000003249 116.0
TLS3_k127_2611423_2 transferase activity, transferring glycosyl groups - - - 0.0000000000001751 81.0
TLS3_k127_2693886_0 SnoaL-like polyketide cyclase - - - 0.0000000000000002526 86.0
TLS3_k127_2693886_1 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000008664 69.0
TLS3_k127_2693886_2 Glyoxalase-like domain K06996 - - 0.00006204 50.0
TLS3_k127_2693886_3 SPTR Transposase, IS4 family protein - - - 0.000158 44.0
TLS3_k127_2717028_0 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.00000000000009453 79.0
TLS3_k127_2754501_0 Type III restriction enzyme, res subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000093 432.0
TLS3_k127_2754501_1 FAD dependent oxidoreductase K15736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 387.0
TLS3_k127_2754501_10 divalent heavy-metal cations transporter - - - 0.000000001513 64.0
TLS3_k127_2754501_2 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 336.0
TLS3_k127_2754501_3 DEAD DEAH box helicase domain protein K10896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009709 309.0
TLS3_k127_2754501_4 Protein of unknown function (DUF790) K09744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005458 288.0
TLS3_k127_2754501_5 PAC2 family K06869 - - 0.00000000000000000000000000000000000000000000000000006271 198.0
TLS3_k127_2754501_7 - - - - 0.0000000000000000000001267 100.0
TLS3_k127_2754501_8 SPTR Transposase, IS4 family protein - - - 0.0000000000002908 72.0
TLS3_k127_2754501_9 PFAM transposase, IS4 family protein - - - 0.00000000004639 70.0
TLS3_k127_2772777_0 Universal stress protein - - - 0.0000000000000000000000000000006124 128.0
TLS3_k127_2772777_1 Protein of unknown function DUF72 - - - 0.000001045 50.0
TLS3_k127_2808719_0 iron dependent repressor - - - 0.00000000000000000000000000000000000000000006402 164.0
TLS3_k127_2808719_1 Transglutaminase/protease-like homologues K01456 - 3.5.1.52 0.0000000000000000000000000000003429 132.0
TLS3_k127_2882960_1 Uncharacterized ACR, COG1993 K09137 - - 0.00000000000007158 74.0
TLS3_k127_2882960_2 Transposase - - - 0.0000008472 51.0
TLS3_k127_2932455_0 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 502.0
TLS3_k127_2932455_1 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000001809 271.0
TLS3_k127_2932455_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000001519 232.0
TLS3_k127_2932455_3 HAD-superfamily hydrolase, subfamily IA, variant 3 K01091,K01838,K07025 - 3.1.3.18,5.4.2.6 0.000000000000000000000000000000000000000000006905 171.0
TLS3_k127_2932455_4 Glycosyltransferase Family 4 - - - 0.0000000000000000000103 105.0
TLS3_k127_2932455_5 - - - - 0.000000001273 65.0
TLS3_k127_2932455_6 Mediates influx of magnesium ions K03284 - - 0.000000003527 61.0
TLS3_k127_2965918_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0050897,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.17.19 1.122e-264 821.0
TLS3_k127_2965918_1 - - - - 0.000000000000000000000000000000000009976 147.0
TLS3_k127_2965918_10 PFAM Integrase catalytic region - - - 0.000003005 54.0
TLS3_k127_2965918_11 Cupin domain K07155 - 1.13.11.24 0.00002662 48.0
TLS3_k127_2965918_12 Homeodomain-like domain K07494,K07499 - - 0.00004465 50.0
TLS3_k127_2965918_13 Peptidyl-tRNA hydrolase K04794 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0010941,GO:0010942,GO:0016787,GO:0016788,GO:0019222,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0052689,GO:0060255,GO:0060548,GO:0065007,GO:0140098,GO:0140101,GO:2000209,GO:2000210,GO:2000811 3.1.1.29 0.00008782 48.0
TLS3_k127_2965918_14 serine-type endopeptidase activity K00505,K01342,K02035 - 1.14.18.1,3.4.21.62 0.0001164 55.0
TLS3_k127_2965918_2 COGs COG3467 flavin-nucleotide-binding protein K07005 - - 0.00000000000000000000000000000000009652 139.0
TLS3_k127_2965918_3 Belongs to the UPF0255 family - - - 0.0000000000000000000000002181 109.0
TLS3_k127_2965918_4 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.0000000000000000006129 95.0
TLS3_k127_2965918_5 ester cyclase K06893 - - 0.00000000000000004548 82.0
TLS3_k127_2965918_6 methyltransferase K21172 - - 0.000000000000005155 78.0
TLS3_k127_2965918_7 Methyltransferase type 11 - - - 0.0000000001505 65.0
TLS3_k127_2965918_8 Transposase DDE domain K07492 - - 0.0000000002082 62.0
TLS3_k127_2965918_9 Transposase DDE domain K07492 - - 0.000000006342 57.0
TLS3_k127_3006202_0 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 412.0
TLS3_k127_3006202_1 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000003255 232.0
TLS3_k127_3006202_2 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - 0.00000000000000000000000000001327 118.0
TLS3_k127_3006202_3 metal-dependent protease of the PAD1 JAB1 superfamily K21140 - 3.13.1.6 0.0000000000000000003934 93.0
TLS3_k127_3006202_4 endonuclease K00986 - 2.7.7.49 0.0000000000000001637 82.0
TLS3_k127_3006725_0 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.00000000000000000000003762 102.0
TLS3_k127_3006725_3 Domain of unknown function (DUF4440) - - - 0.0000000001061 62.0
TLS3_k127_3015365_2 Transcriptional regulatory protein, C terminal K02483 - - 0.00001513 57.0
TLS3_k127_3074294_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002601 270.0
TLS3_k127_3074294_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000001448 242.0
TLS3_k127_3074294_2 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000001064 227.0
TLS3_k127_3074294_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000001196 207.0
TLS3_k127_3074294_4 - - - - 0.0000000000000000000002298 99.0
TLS3_k127_3074294_5 metalloendopeptidase activity K08006 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0016787,GO:0019538,GO:0031012,GO:0043170,GO:0044238,GO:0044421,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.0002928 51.0
TLS3_k127_3092973_0 pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000001772 167.0
TLS3_k127_3092973_1 PFAM Alcohol dehydrogenase GroES-like domain K00001,K13953,K18382 - 1.1.1.1 0.000000000000000000000000000000005006 130.0
TLS3_k127_3111871_0 Alpha beta hydrolase K01066,K14731 - 3.1.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005705 309.0
TLS3_k127_3111871_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000193 216.0
TLS3_k127_3123218_0 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K04763 - - 0.00000000001682 74.0
TLS3_k127_3123218_1 MgtC family K07507 - - 0.000008409 48.0
TLS3_k127_3133737_0 PFAM TCP-1 cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 1.844e-241 756.0
TLS3_k127_3133737_1 transcriptional K07721 - - 0.00000000000000000000000000000000000000000000002951 179.0
TLS3_k127_3133737_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000002514 135.0
TLS3_k127_3144467_0 NADPH-dependent F420 reductase K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000004034 261.0
TLS3_k127_3144467_1 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000003889 139.0
TLS3_k127_3144467_2 Mut7-C RNAse domain K09122 - - 0.000000000000006313 78.0
TLS3_k127_3144467_3 Mut7-C RNAse domain K09122 - - 0.00000001682 57.0
TLS3_k127_3144467_4 ester cyclase K06893 - - 0.00000008366 57.0
TLS3_k127_3191318_0 COG0474 Cation transport ATPase K01537 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 603.0
TLS3_k127_3191318_1 PFAM Isochorismatase - - - 0.00000000000000000000000000000000000000000000003498 175.0
TLS3_k127_3191318_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000009402 128.0
TLS3_k127_3199338_0 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 476.0
TLS3_k127_3199338_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 445.0
TLS3_k127_3199338_10 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000126 230.0
TLS3_k127_3199338_11 ERCC4 domain K10848 - - 0.0000000000000000000000000000000000000000000000000000000000000001223 229.0
TLS3_k127_3199338_12 Pyridoxamine 5'-phosphate K07005 - - 0.0000000000000000000000000000000000000000000000000000000008605 210.0
TLS3_k127_3199338_13 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.0000000000000000000000000000000000000001103 154.0
TLS3_k127_3199338_14 ribosomal protein K02883 - - 0.0000000000000000000000000000000000004239 142.0
TLS3_k127_3199338_15 Ribosomal L37ae protein family K02921 - - 0.000000000000000000000000000007971 119.0
TLS3_k127_3199338_17 - - - - 0.00000000000000000000218 97.0
TLS3_k127_3199338_2 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 406.0
TLS3_k127_3199338_3 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 383.0
TLS3_k127_3199338_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 376.0
TLS3_k127_3199338_5 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 374.0
TLS3_k127_3199338_6 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 314.0
TLS3_k127_3199338_7 DNA-directed RNA polymerase, alpha subunit 40 kD subunit K03047 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006615 302.0
TLS3_k127_3199338_8 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004629 279.0
TLS3_k127_3199338_9 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000000000005277 233.0
TLS3_k127_322668_0 Sodium:sulfate symporter transmembrane region K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007433 545.0
TLS3_k127_322668_1 Ion transporter K08714 - - 0.00000000000000000000000000000000000000000000000000003348 197.0
TLS3_k127_322668_2 Methyltransferase - - - 0.0000000000000000000000000000000000009372 143.0
TLS3_k127_322668_3 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000001964 132.0
TLS3_k127_322668_4 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000388 125.0
TLS3_k127_322668_5 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000001453 63.0
TLS3_k127_322668_6 - - - - 0.0001643 45.0
TLS3_k127_322668_7 Winged helix-turn helix - - - 0.0003638 46.0
TLS3_k127_322668_8 zinc finger protein - GO:0000981,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007154,GO:0007165,GO:0007166,GO:0007219,GO:0007275,GO:0007424,GO:0008150,GO:0009653,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010646,GO:0010647,GO:0019219,GO:0019222,GO:0023051,GO:0023052,GO:0023056,GO:0030510,GO:0030513,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0035277,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043565,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046982,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0060541,GO:0065007,GO:0070013,GO:0080090,GO:0090092,GO:0090100,GO:0090287,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.0005997 43.0
TLS3_k127_3235795_0 SPTR Transposase, IS4 family protein - - - 0.0000000000000000000000000000001887 128.0
TLS3_k127_3235795_2 DUF1264-domain-containing protein - - - 0.000000000001575 76.0
TLS3_k127_3248765_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 385.0
TLS3_k127_3248765_1 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000192 229.0
TLS3_k127_3248765_2 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.00000000000000000000000000004037 120.0
TLS3_k127_3248765_3 Transposase - - - 0.00000000000000000169 88.0
TLS3_k127_3248765_4 PFAM transcriptional regulator PadR family protein - - - 0.0000000000000002596 85.0
TLS3_k127_3248765_5 Putative transposase of IS4/5 family (DUF4096) - - - 0.000000001024 60.0
TLS3_k127_3261377_0 GMC oxidoreductase K03333 - 1.1.3.6 0.000000000000000000000000000003052 139.0
TLS3_k127_3261377_1 - - - - 0.000000000000000000000001819 117.0
TLS3_k127_3275737_0 Pfam:DUF385 - - - 0.00000000000000000000000000158 114.0
TLS3_k127_3275737_1 Pfam:DUF385 - - - 0.000000000007233 68.0
TLS3_k127_3284540_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 5.74e-237 746.0
TLS3_k127_3284540_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K01953,K06927 - 6.3.1.14,6.3.5.4 5.296e-196 626.0
TLS3_k127_3284540_10 ATP synthase subunit C K02124 - - 0.000000000000000000000000007332 113.0
TLS3_k127_3284540_11 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.000000000000000007688 88.0
TLS3_k127_3284540_12 - - - - 0.0000000000004767 79.0
TLS3_k127_3284540_13 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000008216 73.0
TLS3_k127_3284540_14 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000001051 59.0
TLS3_k127_3284540_2 Mannosyl-3-phosphoglycerate synthase K05947 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.217 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007621 524.0
TLS3_k127_3284540_3 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008579 386.0
TLS3_k127_3284540_4 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 335.0
TLS3_k127_3284540_5 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001763 255.0
TLS3_k127_3284540_6 phosphoserine phosphatase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000001841 239.0
TLS3_k127_3284540_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000008424 235.0
TLS3_k127_3284540_8 - - - - 0.000000000000000000000000000000000000386 153.0
TLS3_k127_3284540_9 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000001751 134.0
TLS3_k127_3336553_0 NAD(P)H-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003481 265.0
TLS3_k127_3336553_1 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000006808 175.0
TLS3_k127_3336553_2 Nodulation protein S (NodS) - - - 0.000000000005067 75.0
TLS3_k127_3408698_0 Transposase and inactivated derivatives K07494,K07499 - - 0.0000000003086 66.0
TLS3_k127_3408698_1 DDE superfamily endonuclease - - - 0.00004346 49.0
TLS3_k127_3476462_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 426.0
TLS3_k127_3476462_1 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000002681 221.0
TLS3_k127_3476462_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000002451 115.0
TLS3_k127_3540116_0 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000009422 172.0
TLS3_k127_3540116_1 Ribonuclease K03469 - 3.1.26.4 0.0000000000001022 73.0
TLS3_k127_3540615_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 1.186e-275 865.0
TLS3_k127_3540615_1 TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 - 2.6.1.16 1.786e-221 704.0
TLS3_k127_3540615_10 glycine decarboxylation via glycine cleavage system K02437 - - 0.00000000000000007564 86.0
TLS3_k127_3540615_11 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.0002204 49.0
TLS3_k127_3540615_2 Peptidase family M3 K08602 - - 1.805e-220 698.0
TLS3_k127_3540615_3 PFAM S-layer - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 359.0
TLS3_k127_3540615_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000002621 235.0
TLS3_k127_3540615_5 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000000000000000126 228.0
TLS3_k127_3540615_6 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000000000000000003916 206.0
TLS3_k127_3540615_7 protein (ATP-grasp superfamily) K07159 - - 0.0000000000000000000000000000000000000000000000000000008656 202.0
TLS3_k127_3540615_8 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.0000000000000000000000000000166 122.0
TLS3_k127_3540615_9 - - - - 0.0000000000000000000003521 107.0
TLS3_k127_35636_0 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 1.23e-302 942.0
TLS3_k127_35636_1 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 2.194e-218 681.0
TLS3_k127_35636_10 AhpC/TSA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 370.0
TLS3_k127_35636_11 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 363.0
TLS3_k127_35636_12 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 346.0
TLS3_k127_35636_13 Belongs to the complex I 20 kDa subunit family K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 325.0
TLS3_k127_35636_14 4Fe-4S binding domain K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006858 311.0
TLS3_k127_35636_15 Amino acid kinase family K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000000000000643 237.0
TLS3_k127_35636_16 NADH ubiquinone oxidoreductase 27 kD subunit K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000009376 214.0
TLS3_k127_35636_17 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 3 K00330 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000001324 206.0
TLS3_k127_35636_18 uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000003424 199.0
TLS3_k127_35636_19 AhpC/TSA antioxidant enzyme K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000001642 195.0
TLS3_k127_35636_2 NADH ubiquinone oxidoreductase subunit 2 (Chain N) K22169 - 1.5.98.3 4.425e-214 674.0
TLS3_k127_35636_20 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000001439 192.0
TLS3_k127_35636_21 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000008703 150.0
TLS3_k127_35636_22 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000000009114 128.0
TLS3_k127_35636_23 NADH ubiquinone oxidoreductase subunit 11 or 4L (chain K) K00340 - 1.6.5.3 0.000000000000000000000000000007594 121.0
TLS3_k127_35636_3 Proton-conducting membrane transporter K00342 - 1.6.5.3 3.355e-206 657.0
TLS3_k127_35636_4 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007623 608.0
TLS3_k127_35636_5 NADH dehydrogenase K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 589.0
TLS3_k127_35636_6 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005579 519.0
TLS3_k127_35636_7 geranylgeranyl reductase K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 501.0
TLS3_k127_35636_8 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 460.0
TLS3_k127_35636_9 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 449.0
TLS3_k127_358270_0 Thioredoxin K03671 - - 0.000000000000000000000000000000000000000000000001034 175.0
TLS3_k127_358270_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000009055 66.0
TLS3_k127_3595698_0 Belongs to the UPF0255 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 414.0
TLS3_k127_3595698_1 UPF0056 membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000004091 220.0
TLS3_k127_3595698_2 - - - - 0.00000000000000000000000000000001255 130.0
TLS3_k127_360469_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000006679 141.0
TLS3_k127_360469_1 CBS domain - - - 0.0000000000000000003247 98.0
TLS3_k127_360469_3 CBS domain - - - 0.00005667 50.0
TLS3_k127_3684627_0 Transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.0000000000000001161 91.0
TLS3_k127_3684627_1 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000002891 75.0
TLS3_k127_3687337_0 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000007103 244.0
TLS3_k127_3687337_1 integrase family - - - 0.00000000000000000000001561 106.0
TLS3_k127_3687337_2 Transcriptional regulator - - - 0.00000000000001016 77.0
TLS3_k127_3738518_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 3.9e-322 1002.0
TLS3_k127_3738518_1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000001822 136.0
TLS3_k127_375116_0 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 309.0
TLS3_k127_375116_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007132 299.0
TLS3_k127_375116_2 regulatory protein, arsR - - - 0.0000000000000000000000003405 108.0
TLS3_k127_375116_3 Activator of Hsp90 ATPase - - - 0.000000000000000000000002285 108.0
TLS3_k127_375116_4 methyl-accepting chemotaxis protein K03406 - - 0.000000000000000002783 93.0
TLS3_k127_3956443_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001746 284.0
TLS3_k127_3956443_1 Periplasmic solute binding protein K09815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008249 251.0
TLS3_k127_3956443_10 Periplasmic copper-binding protein (NosD) - - - 0.000000000000004763 88.0
TLS3_k127_3956443_11 PFAM blue (type 1) copper domain protein - - - 0.0000000000001176 84.0
TLS3_k127_3956443_12 Transposase - - - 0.0000000000005289 74.0
TLS3_k127_3956443_13 - - - - 0.000000003226 62.0
TLS3_k127_3956443_14 Multicopper oxidase - - - 0.000001289 51.0
TLS3_k127_3956443_15 Antibiotic biosynthesis monooxygenase - - - 0.000002145 53.0
TLS3_k127_3956443_16 SPTR Transposase, IS4 family protein - - - 0.000002599 50.0
TLS3_k127_3956443_17 - - - - 0.000002617 53.0
TLS3_k127_3956443_18 COG3335 Transposase and inactivated derivatives K07494 - - 0.0008007 44.0
TLS3_k127_3956443_2 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009954 245.0
TLS3_k127_3956443_3 Hydrolase, alpha beta domain protein K00433 - 1.11.1.10 0.000000000000000000000000000000000000000000000000000001246 206.0
TLS3_k127_3956443_4 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000000000000000008993 199.0
TLS3_k127_3956443_5 Hydrolase, alpha beta domain protein K00433 - 1.11.1.10 0.000000000000000000000000000000000000000000001884 179.0
TLS3_k127_3956443_6 - - - - 0.000000000000000000000000000000000000000000002672 173.0
TLS3_k127_3956443_7 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000004152 166.0
TLS3_k127_3956443_8 Ribbon-helix-helix protein, copG family K07722 - - 0.0000000000000000000000000000000000000002843 153.0
TLS3_k127_3956443_9 - - - - 0.000000000000000236 83.0
TLS3_k127_400545_0 PFAM Aldehyde dehydrogenase K00135,K18601 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005823 590.0
TLS3_k127_400545_1 Galactose oxidase, central domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 327.0
TLS3_k127_400545_10 glucosylceramidase activity - - - 0.000000000000000000000000003401 113.0
TLS3_k127_400545_11 ChaB K06197 - - 0.0000000000000002379 84.0
TLS3_k127_400545_12 - - - - 0.000000000000007241 79.0
TLS3_k127_400545_13 Rhodanese Homology Domain - - - 0.000000000002052 70.0
TLS3_k127_400545_14 PFAM Luciferase-like monooxygenase K04091 - 1.14.14.5 0.00000001165 66.0
TLS3_k127_400545_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 321.0
TLS3_k127_400545_3 UPF0126 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001649 258.0
TLS3_k127_400545_4 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000000009363 229.0
TLS3_k127_400545_5 PFAM Creatininase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000001503 218.0
TLS3_k127_400545_6 tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000009804 166.0
TLS3_k127_400545_7 - - - - 0.00000000000000000000000000000000000000001363 163.0
TLS3_k127_400545_8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000327 136.0
TLS3_k127_4010509_0 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 313.0
TLS3_k127_4010509_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002464 224.0
TLS3_k127_4010509_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function - - - 0.00000000000000000000000000000000000000000000000002892 186.0
TLS3_k127_4093432_0 NAD-dependent epimerase dehydratase K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 400.0
TLS3_k127_4093432_1 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000001145 200.0
TLS3_k127_4093432_2 - - - - 0.00000000000000000000005155 106.0
TLS3_k127_4093432_3 Cobalamin B12-binding domain protein K16955,K22491 - - 0.0000000000009464 71.0
TLS3_k127_4093432_4 - - - - 0.000000001039 63.0
TLS3_k127_415772_0 protein (ATP-grasp superfamily) K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 300.0
TLS3_k127_415772_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007438 257.0
TLS3_k127_415772_2 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.0000000000000000000000000000000001373 136.0
TLS3_k127_415772_3 Transcriptional regulator - - - 0.000000000000000009972 85.0
TLS3_k127_419131_0 Radical SAM - - - 3.656e-315 968.0
TLS3_k127_419131_1 Sodium:sulfate symporter transmembrane region K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 578.0
TLS3_k127_419131_2 oxidoreductase FAD NAD(P)-binding K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005572 477.0
TLS3_k127_419131_3 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000003061 187.0
TLS3_k127_419131_4 - - - - 0.000000000000000000000000000000000000000003329 156.0
TLS3_k127_419131_5 Staphylococcal nuclease homologue - - - 0.000000000000000000000000000006114 128.0
TLS3_k127_419131_6 Phage integrase family - - - 0.0000000001276 64.0
TLS3_k127_419131_7 protein secretion K21449 - - 0.000000009236 65.0
TLS3_k127_419131_8 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000002308 63.0
TLS3_k127_419131_9 Phage integrase family - - - 0.0001492 49.0
TLS3_k127_4227681_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 504.0
TLS3_k127_4227681_1 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 380.0
TLS3_k127_4227681_10 Probable cobalt transporter subunit (CbtB) - - - 0.000000000000002198 79.0
TLS3_k127_4227681_11 Sodium hydrogen exchanger K03455 - - 0.0000002827 53.0
TLS3_k127_4227681_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 359.0
TLS3_k127_4227681_3 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 335.0
TLS3_k127_4227681_4 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000001443 270.0
TLS3_k127_4227681_5 Phosphate uptake regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003627 265.0
TLS3_k127_4227681_6 Pantothenate synthetase K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000004776 245.0
TLS3_k127_4227681_7 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000002182 184.0
TLS3_k127_4227681_8 PFAM Zn-finger in ubiquitin-hydrolases and other protein - - - 0.00000000000000000000000000000002996 127.0
TLS3_k127_4227681_9 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000002493 108.0
TLS3_k127_425620_0 ZIP Zinc transporter K07238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003883 286.0
TLS3_k127_425620_1 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002524 269.0
TLS3_k127_425620_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000001106 156.0
TLS3_k127_425620_3 CBS domain K07182 - - 0.0000000000000000000000000000000006554 141.0
TLS3_k127_425620_4 - - - - 0.00000000000008161 78.0
TLS3_k127_431463_0 F5/8 type C domain - - - 0.000000000000000000000000000001513 131.0
TLS3_k127_4322379_0 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000038 288.0
TLS3_k127_4322379_1 - - - - 0.00000000000000000000000000000000000000000000006556 176.0
TLS3_k127_4322379_10 Transposase and inactivated derivatives - - - 0.0001126 50.0
TLS3_k127_4322379_11 - - - - 0.0006607 51.0
TLS3_k127_4322379_2 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000000000000000000000000000000000000000000009197 168.0
TLS3_k127_4322379_3 Patch-forming domain C2 of tRNA-guanine transglycosylase K07398 - - 0.000000000000000000000000000000000000000000007506 168.0
TLS3_k127_4322379_4 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000005864 154.0
TLS3_k127_4322379_5 transcription factor, homolog of eukaryotic MBF1 K03627 - - 0.000000000000000000000000000001919 126.0
TLS3_k127_4322379_6 Transposase - - - 0.00000000000000000000000000005728 121.0
TLS3_k127_4322379_7 Transposase - - - 0.0000000000002196 71.0
TLS3_k127_4322379_9 - K12208 - - 0.00007821 51.0
TLS3_k127_4365215_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.379e-215 674.0
TLS3_k127_4365215_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.341e-196 623.0
TLS3_k127_4365215_10 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008434 303.0
TLS3_k127_4365215_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001548 283.0
TLS3_k127_4365215_12 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family - GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016427,GO:0016428,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000095 267.0
TLS3_k127_4365215_13 PFAM TfuA domain protein, core - - - 0.00000000000000000000000000000000000000000000000000000000000000000002022 238.0
TLS3_k127_4365215_14 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000002393 237.0
TLS3_k127_4365215_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002856 237.0
TLS3_k127_4365215_16 F420-0:Gamma-glutamyl ligase - - - 0.00000000000000000000000000000000000000000000000000000000000003628 223.0
TLS3_k127_4365215_17 Ribose 5-phosphate isomerase K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000005204 207.0
TLS3_k127_4365215_18 - - - - 0.0000000000000000000000000000000000000000000000000000001816 199.0
TLS3_k127_4365215_19 - - - - 0.0000000000000000000000000000000000000000000000000000004651 206.0
TLS3_k127_4365215_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006809 612.0
TLS3_k127_4365215_20 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000002147 198.0
TLS3_k127_4365215_21 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000002298 196.0
TLS3_k127_4365215_22 Ribosome biogenesis protein, C-terminal K09140 - - 0.0000000000000000000000000000000000000000000000004057 180.0
TLS3_k127_4365215_23 - - - - 0.00000000000000000000000000000000000000000007067 167.0
TLS3_k127_4365215_24 PUA domain K07575 - - 0.0000000000000000000000000000000000000007986 154.0
TLS3_k127_4365215_25 Signal peptidase K13280 - 3.4.21.89 0.0000000000000000000000000000000000005904 147.0
TLS3_k127_4365215_26 Methyltransferase small domain K02493 - 2.1.1.297 0.0000000000000000000000000000000000389 141.0
TLS3_k127_4365215_27 - - - - 0.00000000000000000000000000000000006324 136.0
TLS3_k127_4365215_28 - - - - 0.0000000000000000000000000000000001403 134.0
TLS3_k127_4365215_29 snRNP Sm proteins K04796 - - 0.000000000000000000000000000000001655 130.0
TLS3_k127_4365215_3 methanogenesis marker protein 1 K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009061 552.0
TLS3_k127_4365215_30 Guanylyl transferase CofC like K14941 - 2.7.7.68 0.000000000000000000000000007609 119.0
TLS3_k127_4365215_31 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000002319 109.0
TLS3_k127_4365215_32 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000001259 110.0
TLS3_k127_4365215_33 Binds to the 23S rRNA K02922 - - 0.000000000000000000000004717 101.0
TLS3_k127_4365215_34 PFAM ribonuclease H K03469,K06864 - 3.1.26.4 0.0000000000000000000001247 102.0
TLS3_k127_4365215_35 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000002648 101.0
TLS3_k127_4365215_36 Protein involved in ribosomal biogenesis, contains PUA domain K07565 - - 0.000000000000009035 85.0
TLS3_k127_4365215_38 - - - - 0.00000001685 65.0
TLS3_k127_4365215_4 Isocitrate isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008438 541.0
TLS3_k127_4365215_5 small GTP-binding protein K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 529.0
TLS3_k127_4365215_6 Amidohydrolase family K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 531.0
TLS3_k127_4365215_7 Formyl transferase K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 390.0
TLS3_k127_4365215_8 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 308.0
TLS3_k127_4365215_9 ABC-type antimicrobial peptide transport system, ATPase component K02003,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 309.0
TLS3_k127_43947_0 Belongs to the peptidase M50B family - GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008357 359.0
TLS3_k127_43947_1 - - - - 0.000000000000000000000000000000000136 147.0
TLS3_k127_43947_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000003622 119.0
TLS3_k127_43947_3 Winged helix-turn helix K07494 - - 0.00000004537 62.0
TLS3_k127_43947_4 DDE superfamily endonuclease K07494 - - 0.0004458 49.0
TLS3_k127_4403969_0 TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 428.0
TLS3_k127_4403969_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002686 253.0
TLS3_k127_4403969_2 COG2002 Regulators of stationary sporulation gene expression - - - 0.0000000000000000000000003743 107.0
TLS3_k127_4404365_0 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.0000000000004641 68.0
TLS3_k127_4410327_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000008332 231.0
TLS3_k127_4410327_1 TIGRFAM 2-methylcitrate synthase citrate synthase II K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000002635 209.0
TLS3_k127_4410327_2 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000002437 67.0
TLS3_k127_4437661_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1422.0
TLS3_k127_4437661_1 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 1.638e-279 872.0
TLS3_k127_4437661_10 NADH ubiquinone oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000001061 212.0
TLS3_k127_4437661_11 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000000000000000000000004759 182.0
TLS3_k127_4437661_12 - - - - 0.00000000000000000000000000000102 128.0
TLS3_k127_4437661_13 - - - - 0.000000000000000000001964 100.0
TLS3_k127_4437661_14 Acetyltransferase (GNAT) family - - - 0.0000000000000000003146 91.0
TLS3_k127_4437661_15 Transcriptional regulator - - - 0.00000000000000002949 83.0
TLS3_k127_4437661_16 - - - - 0.00000000000006378 81.0
TLS3_k127_4437661_17 - - - - 0.0000000000007043 73.0
TLS3_k127_4437661_18 Transcription factor zinc-finger K09981 - - 0.000000002484 59.0
TLS3_k127_4437661_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 607.0
TLS3_k127_4437661_3 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 555.0
TLS3_k127_4437661_4 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006004 534.0
TLS3_k127_4437661_5 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 423.0
TLS3_k127_4437661_6 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008465 342.0
TLS3_k127_4437661_7 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 329.0
TLS3_k127_4437661_8 TIGRFAM precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009562 318.0
TLS3_k127_4437661_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002857 263.0
TLS3_k127_4445660_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 500.0
TLS3_k127_4445660_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 456.0
TLS3_k127_4445660_13 mttA/Hcf106 family K03116 - - 0.00000000000001242 79.0
TLS3_k127_4445660_14 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000009414 53.0
TLS3_k127_4445660_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 441.0
TLS3_k127_4445660_3 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K11131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005177 435.0
TLS3_k127_4445660_4 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009241 302.0
TLS3_k127_4445660_5 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005159 267.0
TLS3_k127_4445660_6 Redoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005366 256.0
TLS3_k127_4445660_7 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008386 264.0
TLS3_k127_4445660_8 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000009795 210.0
TLS3_k127_4445660_9 Belongs to the archaeal adenylate kinase family K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000005939 172.0
TLS3_k127_4455990_0 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 332.0
TLS3_k127_4521785_0 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000000000000000000000000007921 124.0
TLS3_k127_4521785_1 Universal stress protein - - - 0.0000000002604 71.0
TLS3_k127_4521785_3 COG3039 Transposase and inactivated derivatives, IS5 family - - - 0.0001754 45.0
TLS3_k127_45537_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 328.0
TLS3_k127_45537_1 Ribose-phosphate pyrophosphokinase K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002688 284.0
TLS3_k127_45537_10 High-affinity Fe2 Pb2 permease K07243 - - 0.00000000000000000000000000005979 117.0
TLS3_k127_45537_11 transcriptional regulators - - - 0.000000000000000000000000002585 114.0
TLS3_k127_45537_12 High-affinity Fe2 Pb2 permease K07243 - - 0.0000000000000000000000001325 112.0
TLS3_k127_45537_13 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000001815 91.0
TLS3_k127_45537_14 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 0.0000000000001772 72.0
TLS3_k127_45537_15 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 0.00001303 50.0
TLS3_k127_45537_16 Copper binding proteins, plastocyanin/azurin family - - - 0.00001815 49.0
TLS3_k127_45537_17 High-affinity Fe2 Pb2 permease K07243 - - 0.0004976 51.0
TLS3_k127_45537_2 Asp/Glu/Hydantoin racemase K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000003904 252.0
TLS3_k127_45537_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000112 248.0
TLS3_k127_45537_4 PFAM Iron dependent repressor, metal binding and dimerisation domain K03709 - - 0.0000000000000000000000000000000000000000000000000000000000000000001049 233.0
TLS3_k127_45537_5 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000008016 235.0
TLS3_k127_45537_6 High-affinity Fe2 Pb2 permease K07243 - - 0.0000000000000000000000000000000000000000000000000000602 191.0
TLS3_k127_45537_7 Putative cyclase - - - 0.00000000000000000000000000000000000000000000003216 177.0
TLS3_k127_45537_9 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000004556 127.0
TLS3_k127_4634664_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 2.834e-277 861.0
TLS3_k127_4634664_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 4.43e-224 704.0
TLS3_k127_4634664_10 RNA methylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005293 248.0
TLS3_k127_4634664_11 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000003347 231.0
TLS3_k127_4634664_12 Binds to the 23S rRNA K02885 - - 0.000000000000000000000000000000000000000000000000000000000005899 210.0
TLS3_k127_4634664_13 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00000000000000000000000000000000000000000000000000001442 199.0
TLS3_k127_4634664_14 Protein phosphatase 2C - - - 0.00000000000000000000000000000000000000000000000004064 190.0
TLS3_k127_4634664_15 ribosomal protein K02912 - - 0.0000000000000000000000000000000000000000000005641 170.0
TLS3_k127_4634664_16 - - - - 0.00000000000000000000000000000000000000000001999 164.0
TLS3_k127_4634664_17 Rieske 2Fe-2S K05710 - - 0.00000000000000000000000000000000000057 141.0
TLS3_k127_4634664_18 CBS domain - - - 0.00000000000000000000000000000000000437 142.0
TLS3_k127_4634664_19 GTPase or GTP-binding protein K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000001236 147.0
TLS3_k127_4634664_2 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 611.0
TLS3_k127_4634664_20 TPR Domain containing protein - - - 0.000000000006504 78.0
TLS3_k127_4634664_21 Belongs to the eIF-2B alpha beta delta subunits family - - - 0.0000000151 62.0
TLS3_k127_4634664_22 ORF D-335-like protein - - - 0.000005509 50.0
TLS3_k127_4634664_23 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00006446 52.0
TLS3_k127_4634664_24 - - - - 0.0003245 49.0
TLS3_k127_4634664_3 Protein kinase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 407.0
TLS3_k127_4634664_4 aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009725 375.0
TLS3_k127_4634664_5 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 355.0
TLS3_k127_4634664_6 PFAM DNA methylase N-4 N-6 domain protein K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 293.0
TLS3_k127_4634664_7 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008746 269.0
TLS3_k127_4634664_8 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009105 270.0
TLS3_k127_4634664_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007123 245.0
TLS3_k127_4691649_0 Major Intrinsic Protein K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 293.0
TLS3_k127_4691649_1 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000001165 175.0
TLS3_k127_4691649_2 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000006771 169.0
TLS3_k127_4691649_3 this gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.0000000000000004161 81.0
TLS3_k127_470575_0 Purple acid Phosphatase, N-terminal domain - - - 0.000000000000000000000000001875 125.0
TLS3_k127_470575_1 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000294 56.0
TLS3_k127_4714028_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 416.0
TLS3_k127_4714028_1 Galactose oxidase, central domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003216 290.0
TLS3_k127_4714028_2 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000319 242.0
TLS3_k127_4714028_3 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000001381 231.0
TLS3_k127_4714028_4 - - - - 0.000000000000000000000000000000002974 136.0
TLS3_k127_4714028_5 - - - - 0.00000000000000000135 91.0
TLS3_k127_4714028_6 Antibiotic biosynthesis monooxygenase - - - 0.000004869 49.0
TLS3_k127_4714028_7 Protein of unknown function (DUF1211) - - - 0.00001303 50.0
TLS3_k127_4714028_8 Antibiotic biosynthesis monooxygenase - - - 0.00004089 48.0
TLS3_k127_4717782_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001863 294.0
TLS3_k127_4717782_1 Multicopper oxidase K22349 - 1.16.3.3 0.0000000000001713 83.0
TLS3_k127_4722366_0 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 295.0
TLS3_k127_4722366_1 PFAM Beta-lactamase K18988 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000004618 224.0
TLS3_k127_4728281_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004389 454.0
TLS3_k127_4728281_1 ferredoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009628 304.0
TLS3_k127_4728281_2 - - - - 0.00000000000000000000000000003538 120.0
TLS3_k127_4752600_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 8.427e-242 763.0
TLS3_k127_4752600_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01581,K01586,K13747 - 4.1.1.17,4.1.1.20,4.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 582.0
TLS3_k127_4752600_10 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000008276 167.0
TLS3_k127_4752600_12 Acylphosphatase K01512 - 3.6.1.7 0.00000000000000000000000002844 110.0
TLS3_k127_4752600_13 Transcriptional regulator - - - 0.000000000000002735 78.0
TLS3_k127_4752600_2 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 461.0
TLS3_k127_4752600_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 431.0
TLS3_k127_4752600_4 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 359.0
TLS3_k127_4752600_5 PFAM 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006566 327.0
TLS3_k127_4752600_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002769 246.0
TLS3_k127_4752600_7 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000002146 233.0
TLS3_k127_4752600_8 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000006401 218.0
TLS3_k127_4752600_9 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000005875 205.0
TLS3_k127_4763368_0 - - - - 0.0000000000000000134 86.0
TLS3_k127_4763959_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 2.965e-273 850.0
TLS3_k127_4763959_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 523.0
TLS3_k127_4763959_10 Ribosomal protein L4 K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 293.0
TLS3_k127_4763959_11 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 295.0
TLS3_k127_4763959_12 8-amino-7-oxononanoate synthase K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 297.0
TLS3_k127_4763959_13 conserved protein implicated in secretion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009918 274.0
TLS3_k127_4763959_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000362 269.0
TLS3_k127_4763959_15 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000001036 269.0
TLS3_k127_4763959_16 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000138 258.0
TLS3_k127_4763959_17 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000219 262.0
TLS3_k127_4763959_18 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009328 250.0
TLS3_k127_4763959_19 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000000000000000102 240.0
TLS3_k127_4763959_2 ribosomal protein L3 K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005186 472.0
TLS3_k127_4763959_20 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000003145 235.0
TLS3_k127_4763959_21 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000000000000000000000000000000002526 231.0
TLS3_k127_4763959_22 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000001912 210.0
TLS3_k127_4763959_23 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000001936 218.0
TLS3_k127_4763959_24 Putative RNA methyltransferase K09142 - - 0.00000000000000000000000000000000000000000000000000000000006003 215.0
TLS3_k127_4763959_25 HIT domain K02503 - - 0.000000000000000000000000000000000000000000007607 167.0
TLS3_k127_4763959_26 Domain of unknown function (DUF371) K09738 - - 0.0000000000000000000000000000000000000001153 154.0
TLS3_k127_4763959_27 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000000000006923 144.0
TLS3_k127_4763959_28 - - - - 0.000000000000000000000000000000001255 132.0
TLS3_k127_4763959_29 Located at the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000001794 118.0
TLS3_k127_4763959_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 475.0
TLS3_k127_4763959_30 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.0000000000000000000000000009612 115.0
TLS3_k127_4763959_31 - - - - 0.00000000000000000000004299 102.0
TLS3_k127_4763959_32 ribosomal protein S14 K02954 - - 0.0000000000000000000001897 97.0
TLS3_k127_4763959_34 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000003142 79.0
TLS3_k127_4763959_35 - - - - 0.0000000001096 69.0
TLS3_k127_4763959_36 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000001622 59.0
TLS3_k127_4763959_37 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.000005493 53.0
TLS3_k127_4763959_39 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 GO:0000172,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0002488 47.0
TLS3_k127_4763959_4 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009709 413.0
TLS3_k127_4763959_5 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000977 394.0
TLS3_k127_4763959_6 Proteasome endopeptidase complex K03432 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 386.0
TLS3_k127_4763959_7 resolvase K14060 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 295.0
TLS3_k127_4763959_8 Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 294.0
TLS3_k127_4763959_9 Binds the lower part of the 30S subunit head K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 292.0
TLS3_k127_4767483_0 RNA-metabolising metallo-beta-lactamase K07041 - - 2.669e-259 811.0
TLS3_k127_4771704_0 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 578.0
TLS3_k127_4771704_1 PFAM Cupin 2, conserved barrel - - - 0.00000000000000000205 91.0
TLS3_k127_4776124_0 Staphylococcal nuclease homologue - - - 0.00000000000000000000000001985 119.0
TLS3_k127_4801104_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000002071 81.0
TLS3_k127_4801104_1 Copper binding proteins, plastocyanin/azurin family - - - 0.0000001802 53.0
TLS3_k127_4801104_2 Protein of unknown function (DUF2283) - - - 0.0003851 45.0
TLS3_k127_4809165_0 oxalate decarboxylase activity K01569 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0033609,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046564,GO:0071704 4.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 581.0
TLS3_k127_4809165_1 Subtilase family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 317.0
TLS3_k127_4809165_2 - - - - 0.000000000000000000000000000000000001199 141.0
TLS3_k127_4809165_3 hydrolase activity, acting on ester bonds K01055 - 3.1.1.24 0.000000000000000000000000000000000007822 150.0
TLS3_k127_4809165_4 - - - - 0.0000006073 56.0
TLS3_k127_4842498_0 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000002804 164.0
TLS3_k127_4842498_1 PFAM blue (type 1) copper domain protein - - - 0.00000000002269 66.0
TLS3_k127_4842498_2 PFAM UspA domain protein - - - 0.00000000006249 70.0
TLS3_k127_4842498_3 Dienelactone hydrolase family - - - 0.000007411 49.0
TLS3_k127_4842498_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0001866 53.0
TLS3_k127_4842498_5 PFAM blue (type 1) copper domain protein - - - 0.0006972 44.0
TLS3_k127_4866480_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 1.481e-297 919.0
TLS3_k127_4866480_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 9.318e-246 766.0
TLS3_k127_4866480_10 cytochrome-c peroxidase activity - - - 0.000000000000000000000000000000000000000000000000001087 193.0
TLS3_k127_4866480_11 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000007821 141.0
TLS3_k127_4866480_12 NUDIX domain - - - 0.00000000000000000000000000000001768 133.0
TLS3_k127_4866480_13 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000003974 116.0
TLS3_k127_4866480_14 - - - - 0.000000000000000005611 88.0
TLS3_k127_4866480_15 YHS domain - - - 0.0000000000001284 72.0
TLS3_k127_4866480_17 - - - - 0.00000001766 57.0
TLS3_k127_4866480_18 - - - - 0.00000001887 58.0
TLS3_k127_4866480_19 Protein tyrosine kinase - - - 0.0000471 53.0
TLS3_k127_4866480_2 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 415.0
TLS3_k127_4866480_3 Isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004818 403.0
TLS3_k127_4866480_4 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 382.0
TLS3_k127_4866480_5 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 381.0
TLS3_k127_4866480_6 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 379.0
TLS3_k127_4866480_7 helix_turn_helix ASNC type K03718 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001419 245.0
TLS3_k127_4866480_8 acetolactate synthase, small K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000001627 245.0
TLS3_k127_4866480_9 UbiA prenyltransferase K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000000004629 239.0
TLS3_k127_4872129_0 component I K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 470.0
TLS3_k127_4872129_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 356.0
TLS3_k127_4872129_2 Glycerate kinase K11529 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000001803 239.0
TLS3_k127_4872129_3 Uncharacterized conserved protein (DUF2203) - - - 0.0000000000000000000000000000000000000000000115 166.0
TLS3_k127_4872129_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03014 - - 0.000000000000000000000000000181 119.0
TLS3_k127_4872129_5 Cyclophilin-like K09143 - - 0.0000000000000000002735 94.0
TLS3_k127_4872129_6 S25 ribosomal protein K02975 - - 0.00000000000001271 74.0
TLS3_k127_4874819_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 357.0
TLS3_k127_4874819_1 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002909 270.0
TLS3_k127_4874819_2 - - - - 0.000000000000000000000001328 109.0
TLS3_k127_4881466_0 Ribonuclease K03469 - 3.1.26.4 0.000000000000000000000000000003555 124.0
TLS3_k127_4881466_1 Transposase DDE domain - - - 0.0000001915 60.0
TLS3_k127_4942647_0 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 1.816e-233 747.0
TLS3_k127_4942647_1 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009262 516.0
TLS3_k127_4942647_10 - - - - 0.000000000000000000007138 95.0
TLS3_k127_4942647_11 - - - - 0.0000000002217 64.0
TLS3_k127_4942647_2 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 512.0
TLS3_k127_4942647_3 Deoxyhypusine synthase K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 440.0
TLS3_k127_4942647_4 Tetrapyrrole (Corrin/Porphyrin) Methylases K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 394.0
TLS3_k127_4942647_5 Tetrapyrrole (Corrin/Porphyrin) Methylases K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 291.0
TLS3_k127_4942647_6 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.00000000000000000000000000000000000000000000000000000000000000000000000001805 255.0
TLS3_k127_4942647_7 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001388 234.0
TLS3_k127_4942647_8 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000000000000000000001357 221.0
TLS3_k127_4942647_9 - - - - 0.0000000000000000000001092 98.0
TLS3_k127_5021734_0 Radical SAM - - - 0.0 1041.0
TLS3_k127_5021734_1 HMGL-like K01649 - 2.3.3.13 4.058e-210 657.0
TLS3_k127_5021734_10 Lysine biosynthesis K05827 - 6.3.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 383.0
TLS3_k127_5021734_11 Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) K05828 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 365.0
TLS3_k127_5021734_12 Lysine biosynthesis K05827 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 346.0
TLS3_k127_5021734_13 diphthine synthase K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008666 340.0
TLS3_k127_5021734_14 D-isomer specific 2-hydroxyacid dehydrogenase K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 314.0
TLS3_k127_5021734_15 Belongs to the MCM family K10726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009893 271.0
TLS3_k127_5021734_16 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000002307 259.0
TLS3_k127_5021734_17 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000001876 226.0
TLS3_k127_5021734_18 Domain of unknown function DUF120 K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000000000000000000001049 218.0
TLS3_k127_5021734_19 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases K01090,K06269 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000003398 216.0
TLS3_k127_5021734_2 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 3.591e-208 650.0
TLS3_k127_5021734_20 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000003558 209.0
TLS3_k127_5021734_21 Cytidylyltransferase-like K00980,K14656 - 2.7.7.2,2.7.7.39 0.000000000000000000000000000000000000000000000000000001633 198.0
TLS3_k127_5021734_22 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000000000000000000000002156 194.0
TLS3_k127_5021734_23 Cobalamin B12-binding domain protein - - - 0.000000000000000000000000000000000000000000003003 175.0
TLS3_k127_5021734_24 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000000000000000000005829 121.0
TLS3_k127_5021734_25 - - - - 0.00000000000000000000000009614 109.0
TLS3_k127_5021734_26 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000000000003881 99.0
TLS3_k127_5021734_27 lysine biosynthesis protein LysW K05826 - - 0.0000000000000000000008921 96.0
TLS3_k127_5021734_28 Toprim domain - - - 0.00000000000000000002545 95.0
TLS3_k127_5021734_29 PFAM GvpD gas vesicle - - - 0.000000000000000001755 99.0
TLS3_k127_5021734_3 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily K05829 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006766 590.0
TLS3_k127_5021734_30 - - - - 0.000000000000000004816 87.0
TLS3_k127_5021734_31 - - - - 0.00000000000001394 76.0
TLS3_k127_5021734_33 - - - - 0.0000000008822 64.0
TLS3_k127_5021734_34 Lipid kinase K07029 - 2.7.1.107 0.0001307 48.0
TLS3_k127_5021734_35 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0005061 44.0
TLS3_k127_5021734_36 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0007427 42.0
TLS3_k127_5021734_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 554.0
TLS3_k127_5021734_5 DNA primase K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 537.0
TLS3_k127_5021734_6 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 516.0
TLS3_k127_5021734_7 Glycosyl transferase family group 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003272 490.0
TLS3_k127_5021734_8 Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine K05831 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 486.0
TLS3_k127_5021734_9 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 475.0
TLS3_k127_5056790_0 phosphohistidine phosphatase, SixA K08296 - - 0.0000000000000000000000000000000001485 138.0
TLS3_k127_5079619_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1359.0
TLS3_k127_5079619_1 Radical SAM K06937 - - 0.0 1098.0
TLS3_k127_5079619_10 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 350.0
TLS3_k127_5079619_11 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 338.0
TLS3_k127_5079619_12 TIGRFAM phosphate ABC transporter K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 335.0
TLS3_k127_5079619_13 TIGRFAM phosphate ABC transporter, phosphate-binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006528 331.0
TLS3_k127_5079619_14 Archaeal transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 322.0
TLS3_k127_5079619_15 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 312.0
TLS3_k127_5079619_16 Conserved hypothetical ATP binding protein K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 299.0
TLS3_k127_5079619_17 Carbon-nitrogen hydrolase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 299.0
TLS3_k127_5079619_18 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000739 286.0
TLS3_k127_5079619_19 PFAM NurA domain - - - 0.000000000000000000000000000000000000000000000000000000000000002255 230.0
TLS3_k127_5079619_2 Thiolase, N-terminal domain K00626 - 2.3.1.9 7.27e-215 671.0
TLS3_k127_5079619_20 PhoU domain K02039 - - 0.00000000000000000000000000000000000000000000000000000000002378 213.0
TLS3_k127_5079619_21 Cytidylyltransferase-like K00952 - 2.7.7.1 0.0000000000000000000000000000000000000000000000000007237 190.0
TLS3_k127_5079619_23 conserved protein implicated in secretion - - - 0.0000000000000000000000000000000000000001733 157.0
TLS3_k127_5079619_25 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.000000000000000000000000000000000000000734 151.0
TLS3_k127_5079619_26 - - - - 0.000000000000000000000000000000000000006986 149.0
TLS3_k127_5079619_27 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000002316 158.0
TLS3_k127_5079619_28 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000001643 109.0
TLS3_k127_5079619_29 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000004074 100.0
TLS3_k127_5079619_3 COG0433 Predicted ATPase K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 615.0
TLS3_k127_5079619_30 HD domain K00951,K01139 - 2.7.6.5,3.1.7.2 0.00000000000000000000004717 106.0
TLS3_k127_5079619_31 Transcriptional regulator - - - 0.000000000000000004569 89.0
TLS3_k127_5079619_32 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07713 - - 0.0002443 51.0
TLS3_k127_5079619_33 - - - - 0.0002641 51.0
TLS3_k127_5079619_4 Anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 557.0
TLS3_k127_5079619_5 oligoendopeptidase F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 492.0
TLS3_k127_5079619_6 aspartate carbamoyltransferase K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008948 424.0
TLS3_k127_5079619_7 Belongs to the enoyl-CoA hydratase isomerase family K01715,K15019 - 4.2.1.116,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 414.0
TLS3_k127_5079619_8 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 408.0
TLS3_k127_5079619_9 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 382.0
TLS3_k127_5082259_1 - - - - 0.00000000004026 70.0
TLS3_k127_5086960_0 DNA polymerase K02319 - 2.7.7.7 0.0 1122.0
TLS3_k127_5086960_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01868 - 6.1.1.3 1.304e-236 747.0
TLS3_k127_5086960_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.273e-231 729.0
TLS3_k127_5086960_3 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008087 545.0
TLS3_k127_5086960_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 427.0
TLS3_k127_5086960_5 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 354.0
TLS3_k127_5086960_6 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000001462 251.0
TLS3_k127_5086960_7 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001046 246.0
TLS3_k127_5086960_8 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000003839 241.0
TLS3_k127_5086960_9 ribosomal protein K02976 - - 0.00000000000000000000000000000000000000000000009394 169.0
TLS3_k127_5087719_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00009391 54.0
TLS3_k127_5098257_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005745 358.0
TLS3_k127_5098257_1 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 298.0
TLS3_k127_5121265_0 Acetyltransferase (GNAT) domain - - - 0.000001232 53.0
TLS3_k127_514715_0 PFAM Alcohol dehydrogenase GroES domain protein, Alcohol dehydrogenase zinc-binding domain protein - - - 0.00000000000000000000000000000000000000001767 164.0
TLS3_k127_514715_1 SPTR Transposase, IS4 family protein - - - 0.0000000000001835 74.0
TLS3_k127_5159609_0 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000001169 167.0
TLS3_k127_5159609_1 Transcriptional regulator - - - 0.000000000000000000000000000001543 122.0
TLS3_k127_5159609_2 - - - - 0.0000000000000000000005414 103.0
TLS3_k127_5227347_3 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000002348 149.0
TLS3_k127_5227347_4 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197 0.0005921 45.0
TLS3_k127_5242976_0 Cysteine desulfurase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 390.0
TLS3_k127_5242976_1 tRNA methyl transferase K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003725 279.0
TLS3_k127_5242976_2 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000008463 162.0
TLS3_k127_5242976_3 AhpC/TSA family K03564 - 1.11.1.15 0.00000000000004984 74.0
TLS3_k127_5252933_0 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000135 215.0
TLS3_k127_5252933_1 PFAM transposase, IS4 family protein - - - 0.00000000000000000000000000006046 126.0
TLS3_k127_5253219_0 DNA polymerase IV (family X) K02347 - - 1.331e-201 646.0
TLS3_k127_5253219_1 TIGRFAM glutamine synthetase, type I K01915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.1.2 4.255e-195 619.0
TLS3_k127_5253219_10 PFAM Transposase DDE domain - - - 0.0004131 46.0
TLS3_k127_5253219_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 419.0
TLS3_k127_5253219_3 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006215 383.0
TLS3_k127_5253219_5 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000001138 246.0
TLS3_k127_5253219_6 DnaJ-class molecular chaperone with C-terminal Zn finger domain - - - 0.0000000000000000000000000000000000000000000001326 175.0
TLS3_k127_5253219_8 DDE superfamily endonuclease - - - 0.0000000000001637 75.0
TLS3_k127_5287317_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 407.0
TLS3_k127_5287317_2 response regulator, receiver - - - 0.00000000000000000000002095 104.0
TLS3_k127_5287317_3 SnoaL-like polyketide cyclase K01061 - 3.1.1.45 0.0000000002353 61.0
TLS3_k127_5289060_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1152.0
TLS3_k127_5289060_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 470.0
TLS3_k127_5289060_10 Associated with various cellular activities K03551 - 3.6.4.12 0.00000000000000000000001937 109.0
TLS3_k127_5289060_11 SRPBCC domain-containing protein - - - 0.0000000000000000002179 93.0
TLS3_k127_5289060_12 SPTR Transposase, IS4 family protein - - - 0.0000639 48.0
TLS3_k127_5289060_2 PFAM Alcohol dehydrogenase K12957,K13979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 432.0
TLS3_k127_5289060_3 PFAM (2R)-phospho-3-sulfolactate synthase ComA K08097 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 4.4.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000895 384.0
TLS3_k127_5289060_4 COG2897 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000004982 266.0
TLS3_k127_5289060_5 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000002159 259.0
TLS3_k127_5289060_6 DJ-1/PfpI family - - - 0.0000000000000000000000000000000000000000000000000000000000000002402 227.0
TLS3_k127_5289060_7 protein with SCP PR1 domains - - - 0.000000000000000000000000000000000000000000000004357 187.0
TLS3_k127_5289060_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000186 106.0
TLS3_k127_5289060_9 SPTR Transposase, IS4 family protein - - - 0.000000000000000000000004533 108.0
TLS3_k127_5300891_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000001404 223.0
TLS3_k127_5300891_1 Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000001061 164.0
TLS3_k127_5300891_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000006239 108.0
TLS3_k127_5300891_3 - - - - 0.0000000000000002661 83.0
TLS3_k127_5300891_4 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0002405 44.0
TLS3_k127_5300891_5 PFAM N-6 DNA methylase K03427 - 2.1.1.72 0.0002547 45.0
TLS3_k127_5302784_0 - - - - 0.000000000000009071 79.0
TLS3_k127_5302784_1 - - - - 0.00000001109 63.0
TLS3_k127_5302784_2 Major facilitator superfamily - - - 0.00004849 48.0
TLS3_k127_5302784_3 sequence-specific DNA binding K03718 - - 0.000402 50.0
TLS3_k127_5316942_0 dihydrofolate reductase - - - 0.00000000000000000000000000000000000000000000000000000001855 203.0
TLS3_k127_5316942_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.00000000000000000000000002619 123.0
TLS3_k127_5319990_0 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 575.0
TLS3_k127_5319990_1 Na+-dependent bicarbonate transporter superfamily K07086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 368.0
TLS3_k127_5319990_2 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000001571 186.0
TLS3_k127_5319990_3 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000003178 171.0
TLS3_k127_5319990_4 Nitrogen regulatory protein P-II - - - 0.00000000000000000000000000006097 118.0
TLS3_k127_5319990_5 Major facilitator superfamily - - - 0.0000000000002182 73.0
TLS3_k127_5319990_6 - - - - 0.000000000001847 69.0
TLS3_k127_5319990_7 - - - - 0.000000000005782 73.0
TLS3_k127_5319990_8 - - - - 0.000000001403 64.0
TLS3_k127_5319990_9 - - - - 0.0000004473 61.0
TLS3_k127_5324432_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000006783 234.0
TLS3_k127_5350836_0 magnesium chelatase K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 581.0
TLS3_k127_5350836_1 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 465.0
TLS3_k127_5350836_2 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 336.0
TLS3_k127_5350836_3 PFAM ABC transporter K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001091 258.0
TLS3_k127_5350836_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000719 247.0
TLS3_k127_5350836_6 Winged helix-turn-helix DNA-binding - - - 0.00000000000000000000000000000009084 132.0
TLS3_k127_5350836_7 - - - - 0.000000000004207 72.0
TLS3_k127_5350836_8 RIO1 family - - - 0.0001071 55.0
TLS3_k127_5351358_0 CBS domain K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 304.0
TLS3_k127_5365000_0 palmitoyl-(protein) hydrolase activity K06999,K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009704 301.0
TLS3_k127_5365000_1 PFAM 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003099 258.0
TLS3_k127_5365000_10 - - - - 0.00003126 50.0
TLS3_k127_5365000_2 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000001882 236.0
TLS3_k127_5365000_3 - - - - 0.0000000000000000000000000000009036 125.0
TLS3_k127_5365000_4 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000001422 123.0
TLS3_k127_5365000_6 integrase family - - - 0.0000000000000000002291 92.0
TLS3_k127_5365000_8 VIT family - - - 0.0000000000000001829 83.0
TLS3_k127_5365000_9 - - - - 0.000003876 52.0
TLS3_k127_5365910_0 COG0346 Lactoylglutathione lyase and related lyases K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 440.0
TLS3_k127_5365910_1 phospholipase Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000000001374 236.0
TLS3_k127_5365910_2 - - - - 0.0000000000000000000000000007605 113.0
TLS3_k127_5367737_0 Transcriptional regulator, TrmB - - - 0.000000000000000000000000000000000000000000000000000000000000000003322 234.0
TLS3_k127_5367737_1 - - - - 0.00000000000000000000000000000000475 132.0
TLS3_k127_5373339_0 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 507.0
TLS3_k127_5373339_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007127 476.0
TLS3_k127_5373339_2 - - - - 0.000000000000000000003373 105.0
TLS3_k127_5373339_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02259 - - 0.000000000000000001843 91.0
TLS3_k127_5373339_4 Endonuclease - - - 0.0001742 51.0
TLS3_k127_5374934_1 Histidine kinase - - - 0.0000000000001459 74.0
TLS3_k127_5381652_1 Cellulase (glycosyl hydrolase family 5) - - - 0.0000000000000000363 96.0
TLS3_k127_5381652_2 CBS domain - - - 0.000000006681 57.0
TLS3_k127_5384716_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 305.0
TLS3_k127_5384716_1 - - - - 0.000959 47.0
TLS3_k127_5386354_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 478.0
TLS3_k127_5386354_1 Predicted membrane protein (DUF2070) K08979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007544 417.0
TLS3_k127_5386354_2 3-hydroxyacyl-CoA dehydrogenase K15016 - 1.1.1.35,4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 323.0
TLS3_k127_5386354_3 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000002987 207.0
TLS3_k127_5386354_4 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.00000000000000000000000000000000000000000008598 167.0
TLS3_k127_5386354_5 Sec61beta family - - - 0.000000000000000001524 87.0
TLS3_k127_5386354_6 - - - - 0.000000000000000001812 89.0
TLS3_k127_538755_0 Type III restriction enzyme, res subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 456.0
TLS3_k127_538755_1 3-hydroxyacyl-CoA dehydrogenase K15016 - 1.1.1.35,4.2.1.17 0.000000000000000000000000000000000000000000000000000003707 194.0
TLS3_k127_538755_2 Belongs to the SUI1 family K03113 - - 0.0000000000000000000000000000003936 122.0
TLS3_k127_5391512_0 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009793 332.0
TLS3_k127_5391512_1 PFAM UspA domain protein - - - 0.0000000000004897 76.0
TLS3_k127_5394973_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 387.0
TLS3_k127_5394973_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 299.0
TLS3_k127_541514_0 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 389.0
TLS3_k127_541514_1 pyridoxamine 5-phosphate K07005 - - 0.0000000000000000000000000000000001259 137.0
TLS3_k127_541514_2 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000001634 113.0
TLS3_k127_541514_3 - - - - 0.0000000000000001804 82.0
TLS3_k127_541514_4 Two component transcriptional regulator, winged helix family K07667,K07668 - - 0.00000015 58.0
TLS3_k127_541514_5 His Kinase A (phosphoacceptor) domain - - - 0.0000005358 58.0
TLS3_k127_541514_6 Glyoxalase-like domain - - - 0.000009893 50.0
TLS3_k127_5434013_0 Belongs to the PdaD family K02626 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000001142 203.0
TLS3_k127_5434013_1 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.000000000000000000000000000000000000000000006677 167.0
TLS3_k127_5440073_1 PFAM CMP dCMP deaminase zinc-binding K01489 - 3.5.4.5 0.00000000000000000000000000000001971 129.0
TLS3_k127_5440073_2 Diacylglycerol kinase catalytic domain - - - 0.000000000000000000000000004398 123.0
TLS3_k127_5440073_3 Iron-binding zinc finger CDGSH type K05710 - - 0.000000000000001256 78.0
TLS3_k127_5440073_4 this gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.00000000009672 64.0
TLS3_k127_5441624_0 Alkylated DNA repair protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005379 280.0
TLS3_k127_5444367_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 400.0
TLS3_k127_5444367_1 PhoB family transcriptional regulator - - - 0.00000000007057 68.0
TLS3_k127_5448802_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000003462 173.0
TLS3_k127_5448802_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000008496 91.0
TLS3_k127_5448802_2 cation transport ATPase - GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 - 0.00000000002781 64.0
TLS3_k127_5448802_3 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.0003504 43.0
TLS3_k127_5458724_0 Mechanosensitive ion channel K16052 - - 0.0000000000000004796 90.0
TLS3_k127_5458724_1 Predicted membrane protein (DUF2254) - - - 0.000000000002371 76.0
TLS3_k127_5458724_2 zinc finger - - - 0.000000008745 57.0
TLS3_k127_5458724_3 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0004564 50.0
TLS3_k127_5463396_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.306e-278 869.0
TLS3_k127_5463396_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 4.142e-196 622.0
TLS3_k127_5463396_2 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 523.0
TLS3_k127_5463396_3 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 412.0
TLS3_k127_5463396_4 glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000002362 199.0
TLS3_k127_5463396_5 ABC-type transport system, involved in lipoprotein release, permease component K02004 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000001451 172.0
TLS3_k127_5463396_6 Belongs to the HAM1 NTPase family K02428 - 3.6.1.66 0.000000000002485 68.0
TLS3_k127_5469934_0 glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008605 395.0
TLS3_k127_5483808_0 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000001436 233.0
TLS3_k127_5483808_1 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000000000000000000000000000000000000000000007218 187.0
TLS3_k127_548644_0 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001753 246.0
TLS3_k127_548644_1 - - - - 0.0000000000000000000004188 102.0
TLS3_k127_548644_2 - - - - 0.0000000000000000002709 92.0
TLS3_k127_5502906_0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000008593 180.0
TLS3_k127_5502906_1 Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity) K01456 GO:0000224,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006056,GO:0006058,GO:0006464,GO:0006508,GO:0006511,GO:0006515,GO:0006516,GO:0006517,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009100,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0019941,GO:0030163,GO:0030433,GO:0033554,GO:0034976,GO:0035966,GO:0035967,GO:0035977,GO:0036211,GO:0036503,GO:0042221,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896,GO:0051603,GO:0051716,GO:0051787,GO:0051788,GO:0070887,GO:0071218,GO:0071310,GO:0071704,GO:0071712,GO:0097466,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901700,GO:1904587 3.5.1.52 0.0000000000000000000000000001477 124.0
TLS3_k127_5517564_0 DSBA oxidoreductase - - - 0.00000000000000000000000000000000000007082 152.0
TLS3_k127_5517564_1 - - - - 0.0000000000000000000000000000000001866 139.0
TLS3_k127_5517564_2 Transposase - - - 0.0003443 44.0
TLS3_k127_5527953_0 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006503 412.0
TLS3_k127_5527953_1 Cobalt chelatase (CbiK) K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000000000000000000000002002 257.0
TLS3_k127_5581295_0 MGS-like domain K01955 - 6.3.5.5 0.0 1493.0
TLS3_k127_5581295_1 carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 408.0
TLS3_k127_5581295_2 tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 331.0
TLS3_k127_5581295_3 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006719 310.0
TLS3_k127_5581295_4 PFAM GCN5-related N-acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000000000002545 229.0
TLS3_k127_5581295_5 Calcineurin-like phosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000004086 179.0
TLS3_k127_5581295_7 - - - - 0.000000008808 65.0
TLS3_k127_5590520_1 PFAM response regulator receiver - - - 0.00000000003266 68.0
TLS3_k127_5590520_2 TIGRFAM tungstate ABC transporter binding protein WtpA K15495 - - 0.00001448 49.0
TLS3_k127_5590520_3 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0008741 42.0
TLS3_k127_5606722_0 NAD(P)H-dependent FMN reductase K00299 - 1.5.1.38 0.0000000000000000000000000000000000000000000000000000000000002715 216.0
TLS3_k127_5606722_1 Na -dependent transporter K03453 - - 0.0000000000000000000000000000000000000000000001803 176.0
TLS3_k127_5606722_2 HTH domain - - - 0.000000000000000000000000000000001036 138.0
TLS3_k127_5606722_3 F5/8 type C domain - - - 0.00001119 52.0
TLS3_k127_5636977_0 COG0346 Lactoylglutathione lyase and related lyases K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 401.0
TLS3_k127_5636977_1 phospholipase Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000001895 199.0
TLS3_k127_5636977_10 SPTR Transposase, IS4 family protein - - - 0.0000005753 52.0
TLS3_k127_5636977_11 COG3316 Transposase and inactivated derivatives K07498 - - 0.000006696 52.0
TLS3_k127_5636977_2 COGs COG1853 Conserved protein domain typically associated with flavoprotein oxygenase DIM6 NTAB family - - - 0.000000000000000000000000000000000000000000000000000003709 197.0
TLS3_k127_5636977_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000004819 130.0
TLS3_k127_5636977_4 Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.00000000000000000000000000005827 119.0
TLS3_k127_5636977_5 Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.0000000000000000000000000001383 121.0
TLS3_k127_5636977_6 CHRD domain - - - 0.000000000000000000000000004632 117.0
TLS3_k127_5636977_7 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.00000000000332 70.0
TLS3_k127_5636977_8 SPTR Transposase, IS4 family protein - - - 0.000000000006926 68.0
TLS3_k127_5636977_9 SPTR Transposase, IS4 family protein - - - 0.000000002799 60.0
TLS3_k127_5640681_0 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009654 493.0
TLS3_k127_5640681_1 Archaeal ammonia monooxygenase subunit A (AmoA) K10944 - 1.14.18.3,1.14.99.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 415.0
TLS3_k127_5640681_2 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000001953 222.0
TLS3_k127_5640681_3 - - - - 0.00000000000000000000000000000000000005073 146.0
TLS3_k127_5691679_0 PFAM Transposase DDE domain K07495 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004735 574.0
TLS3_k127_5691679_1 Archaeal putative transposase ISC1217 K07495 - - 0.0000000000000000002587 87.0
TLS3_k127_5691679_2 Putative restriction endonuclease - - - 0.000000000000000005424 84.0
TLS3_k127_5691679_3 Alpha amylase, catalytic domain K01176 - 3.2.1.1 0.0000000000000002671 78.0
TLS3_k127_5711178_0 Protein of unknown function (DUF421) - - - 0.00000000000000242 82.0
TLS3_k127_5711178_1 COG3316 Transposase and inactivated derivatives K07498 - - 0.00003243 50.0
TLS3_k127_5718405_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 428.0
TLS3_k127_5718405_1 ATPase activity K02017,K15497 - 3.6.3.29,3.6.3.55 0.000000000000000000000000000000000000000000000004111 187.0
TLS3_k127_5718405_2 ABC-type sulfate transport system, permease component K15496 - - 0.000000000000000000000000000000000000000000004901 173.0
TLS3_k127_5732614_0 Succinyl-CoA ligase like flavodoxin domain K18593 - - 3.812e-307 955.0
TLS3_k127_5732614_1 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 581.0
TLS3_k127_5732614_10 low-complexity proteins - - - 0.00000000000000000000000000000000000002152 149.0
TLS3_k127_5732614_12 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000005667 58.0
TLS3_k127_5732614_2 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 431.0
TLS3_k127_5732614_3 Glucose sorbosone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000719 325.0
TLS3_k127_5732614_4 PFAM TPR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004563 270.0
TLS3_k127_5732614_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000007052 231.0
TLS3_k127_5732614_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000001935 220.0
TLS3_k127_5732614_7 Zinc finger domain - - - 0.000000000000000000000000000000000000000000000000000000002219 211.0
TLS3_k127_5732614_8 PBS lyase HEAT-like repeat K06072 - 1.14.99.29 0.000000000000000000000000000000000000000000000000000000005626 202.0
TLS3_k127_5732614_9 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000003424 179.0
TLS3_k127_5757342_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 310.0
TLS3_k127_5757342_1 elongation factor Tu - - - 0.000000000000000000000000000000000000000000000000000000000000000002623 232.0
TLS3_k127_5757342_2 - - - - 0.000000000000000000006243 95.0
TLS3_k127_5757342_3 Putative esterase - - - 0.000001029 52.0
TLS3_k127_5768691_0 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 9.521e-232 728.0
TLS3_k127_5768691_1 TIGRFAM precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 336.0
TLS3_k127_5768691_2 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004219 239.0
TLS3_k127_5817107_0 COG2133 Glucose sorbosone dehydrogenases - - - 1.338e-200 636.0
TLS3_k127_5817107_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 522.0
TLS3_k127_5817107_2 peptidyl-prolyl cis-trans isomerase K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000004648 205.0
TLS3_k127_5817107_3 PFAM TM2 domain containing protein K03686 - - 0.00000000000000008439 85.0
TLS3_k127_5817107_4 Transposase and inactivated derivatives K07494,K07499 - - 0.0000001494 57.0
TLS3_k127_5890007_0 Belongs to the SUI1 family K03113 - - 0.00000000005378 67.0
TLS3_k127_5890007_1 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.0000005753 52.0
TLS3_k127_5890007_2 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.0003718 44.0
TLS3_k127_5908668_0 Histidine kinase - - - 0.000000248 53.0
TLS3_k127_5908668_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0007 43.0
TLS3_k127_592236_0 - - - - 0.000000000000000000000000000000000000000000000000000000001224 211.0
TLS3_k127_592236_1 Nitroreductase - - - 0.000000000000000000000000000001087 124.0
TLS3_k127_592236_2 - - - - 0.000000000000000002977 89.0
TLS3_k127_592649_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 1.197e-219 702.0
TLS3_k127_592649_1 Alpha beta hydrolase K01066,K14731 - 3.1.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 408.0
TLS3_k127_592649_10 ABC 3 transport family K09816 - - 0.00000000000000000000000003642 111.0
TLS3_k127_592649_11 ABC 3 transport family K09816 - - 0.0000000000000000000000002772 111.0
TLS3_k127_592649_12 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.0000000000000000000000006948 110.0
TLS3_k127_592649_13 VIT family - - - 0.0000000000000000000005337 96.0
TLS3_k127_592649_16 VIT family - - - 0.0000000000000008756 78.0
TLS3_k127_592649_17 pyrroloquinoline quinone binding - - - 0.00000000001099 70.0
TLS3_k127_592649_18 Multicopper oxidase K22349 - 1.16.3.3 0.00000000006126 74.0
TLS3_k127_592649_19 VIT family - - - 0.0000000004006 61.0
TLS3_k127_592649_2 Belongs to the Pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009853 383.0
TLS3_k127_592649_20 Belongs to the snRNP Sm proteins family K04796 - - 0.000000003662 60.0
TLS3_k127_592649_21 Transcription factor zinc-finger K09981 - - 0.0000002636 56.0
TLS3_k127_592649_22 VIT family - - - 0.000009793 48.0
TLS3_k127_592649_3 Phosphate uptake regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 382.0
TLS3_k127_592649_4 glycosyl transferase family K01001 - 2.7.8.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007571 355.0
TLS3_k127_592649_5 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000003809 213.0
TLS3_k127_592649_6 Ribbon-helix-helix protein, copG family K07722 - - 0.000000000000000000000000000000000000001261 150.0
TLS3_k127_592649_7 F5/8 type C domain - - - 0.000000000000000000000000000000000000007639 157.0
TLS3_k127_592649_8 Periplasmic solute binding protein K09815 - - 0.00000000000000000000000000000000000001553 148.0
TLS3_k127_592649_9 Transcriptional regulator - - - 0.00000000000000000000000000000000000005842 145.0
TLS3_k127_5968319_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 429.0
TLS3_k127_5968319_1 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.00000000000000000000000001087 115.0
TLS3_k127_5968319_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000007238 51.0
TLS3_k127_5979752_0 GGDEF domain K04767 - - 0.000001434 60.0
TLS3_k127_5987656_0 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.46e-197 619.0
TLS3_k127_5987656_1 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000001198 254.0
TLS3_k127_5987656_2 - - - - 0.000000000000000003949 85.0
TLS3_k127_5987656_3 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.0000000000004641 68.0
TLS3_k127_5991275_0 factor TFIIB K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 335.0
TLS3_k127_5991275_1 SRP19 protein K03105 - - 0.00000000000000000000000000001725 120.0
TLS3_k127_5991275_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000002997 102.0
TLS3_k127_5991275_3 S25 ribosomal protein K02975 - - 0.0000000000001338 74.0
TLS3_k127_5991275_4 RNA-binding protein involved in rRNA processing K07569 - - 0.0000000000002621 74.0
TLS3_k127_6011375_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000001964 158.0
TLS3_k127_6069738_0 3-isopropylmalate dehydratase, large subunit K01703 - 4.2.1.33,4.2.1.35 2.917e-223 699.0
TLS3_k127_6069738_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006112 577.0
TLS3_k127_6069738_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002696 359.0
TLS3_k127_6069738_3 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001381 282.0
TLS3_k127_6069738_4 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000139 212.0
TLS3_k127_6069738_5 PFAM Like-Sm ribonucleoprotein, core - - - 0.0000000000000000000000000000000000000000000000000000002367 197.0
TLS3_k127_6069738_6 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000000001098 134.0
TLS3_k127_6069738_8 PFAM Protein kinase domain - - - 0.0004677 50.0
TLS3_k127_6077988_0 - - - - 0.0004242 51.0
TLS3_k127_6115912_0 Fic/DOC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 383.0
TLS3_k127_6115912_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001047 255.0
TLS3_k127_6182348_0 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000559 345.0
TLS3_k127_6182348_1 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000001171 262.0
TLS3_k127_6182348_2 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000002785 223.0
TLS3_k127_6218004_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 463.0
TLS3_k127_6218004_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 285.0
TLS3_k127_6218004_11 - - - - 0.00000001357 65.0
TLS3_k127_6218004_12 Belongs to the universal stress protein A family - - - 0.00000001641 62.0
TLS3_k127_6218004_2 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001248 264.0
TLS3_k127_6218004_3 Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000000001199 244.0
TLS3_k127_6218004_4 Membrane - - - 0.00000000000000000000000000000000000000000000000001744 190.0
TLS3_k127_6218004_5 Archaeal TRASH domain - - - 0.000000000000000000000000000000000000000009487 159.0
TLS3_k127_6218004_6 - - - - 0.0000000000000000000001966 103.0
TLS3_k127_6218004_7 heme oxygenase (decyclizing) activity - - - 0.0000000000000000000005891 98.0
TLS3_k127_6218004_9 ChaB K06197 - - 0.000000000000005412 77.0
TLS3_k127_6223703_0 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 310.0
TLS3_k127_6223703_1 Cupin domain - - - 0.00000000000000000000000003908 110.0
TLS3_k127_6223703_2 COG0433 Predicted ATPase - - - 0.000000000000000005225 90.0
TLS3_k127_6235100_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K20989 - - 3.244e-261 826.0
TLS3_k127_6235100_2 Urease, alpha subunit K01428 - 3.5.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 490.0
TLS3_k127_6235100_3 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005239 267.0
TLS3_k127_6235100_4 Belongs to the urease beta subunit family K01429,K14048 - 3.5.1.5 0.00000000000000000000000000000000000000000000000000000000566 200.0
TLS3_k127_6235100_5 (urease) gamma subunit K01430,K14048 - 3.5.1.5 0.0000000000000000000000000000000000000000000000008543 175.0
TLS3_k127_625811_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 6.465e-310 981.0
TLS3_k127_625811_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.00000000000000000000000002015 108.0
TLS3_k127_625811_2 - - - - 0.000000000000008243 85.0
TLS3_k127_6264054_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1119.0
TLS3_k127_6264054_1 Universal stress protein - - - 0.00000000000002491 80.0
TLS3_k127_6304598_0 MADS - - - 0.00000000000000000000000001084 110.0
TLS3_k127_6304598_1 MADS K09264 GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006355,GO:0008134,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048518,GO:0048578,GO:0048580,GO:0048582,GO:0048583,GO:0048584,GO:0048586,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051171,GO:0051239,GO:0051240,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000026,GO:2000028,GO:2000112,GO:2000241,GO:2000243,GO:2001141 - 0.000703 42.0
TLS3_k127_6310676_0 - - - - 0.00000000000000000000000000000000000000000000000002625 183.0
TLS3_k127_6310676_1 PGAP1-like protein - - - 0.00000000000000000000000002827 124.0
TLS3_k127_6310948_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005909 286.0
TLS3_k127_6311390_0 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0000000007808 64.0
TLS3_k127_6311390_1 HicA toxin of bacterial toxin-antitoxin, - - - 0.0001254 46.0
TLS3_k127_6314616_1 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000004797 126.0
TLS3_k127_6314616_2 This gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.000000000000005172 77.0
TLS3_k127_6321662_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000003035 267.0
TLS3_k127_6321662_1 PFAM Integrase core domain K07497 - - 0.00000000000000000000000000000000000000000000003388 174.0
TLS3_k127_6321662_2 PFAM Integrase core domain K07497 - - 0.00000000000000000000000000000000000000725 149.0
TLS3_k127_6321662_3 - - - - 0.000000000000000000007278 96.0
TLS3_k127_6321662_4 - - - - 0.00000000000000002085 83.0
TLS3_k127_6321662_5 SPTR Transposase, IS4 family protein - - - 0.000002738 50.0
TLS3_k127_633869_0 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008229 480.0
TLS3_k127_6365500_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 2.672e-286 895.0
TLS3_k127_6365500_1 Potassium-transporting ATPase A subunit K01546 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005797 447.0
TLS3_k127_6368_0 HELICc2 - - - 2.061e-225 711.0
TLS3_k127_6368_1 elongation factor Tu - - - 0.00000000000000000000000000000000000000000000000000002471 194.0
TLS3_k127_6369198_0 Succinyl-CoA ligase like flavodoxin domain K18594 - - 1.812e-240 751.0
TLS3_k127_6369198_1 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 1.777e-228 719.0
TLS3_k127_6369198_10 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000006422 78.0
TLS3_k127_6369198_11 Kinase binding protein CGI-121 - - - 0.00009677 52.0
TLS3_k127_6369198_2 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 596.0
TLS3_k127_6369198_3 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 432.0
TLS3_k127_6369198_4 ATPase family associated with various cellular activities (AAA) K04748 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007622 376.0
TLS3_k127_6369198_5 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 316.0
TLS3_k127_6369198_6 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000206 269.0
TLS3_k127_6369198_7 PFAM GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000004474 136.0
TLS3_k127_6369198_8 THUMP domain K06963 - - 0.00000000000000000000000000000001656 132.0
TLS3_k127_6369198_9 Sua5 YciO YrdC YwlC family K07566 - 2.7.7.87 0.000000000000000000000000000007463 126.0
TLS3_k127_6385316_0 Fumarase C C-terminus K01744 - 4.3.1.1 1.165e-196 622.0
TLS3_k127_6385316_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 552.0
TLS3_k127_6385316_10 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000401 153.0
TLS3_k127_6385316_11 Belongs to the ribosomal protein L31e family K02910 - - 0.00000000000000000000000000000000005566 137.0
TLS3_k127_6385316_12 Tubulin/FtsZ family, GTPase domain K03531 - - 0.00000000000000000000000000000007458 137.0
TLS3_k127_6385316_13 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000003122 123.0
TLS3_k127_6385316_14 Belongs to the eukaryotic ribosomal protein eL39 family K02924 - - 0.00000000000000001933 83.0
TLS3_k127_6385316_15 - - - - 0.000000000000000512 79.0
TLS3_k127_6385316_2 MiaB-like tRNA modifying enzyme K15865 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 466.0
TLS3_k127_6385316_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 351.0
TLS3_k127_6385316_4 NOSIC (NUC001) domain K14564 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 358.0
TLS3_k127_6385316_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family K00555 - 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 325.0
TLS3_k127_6385316_6 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008196 316.0
TLS3_k127_6385316_7 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002869 287.0
TLS3_k127_6385316_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000199 172.0
TLS3_k127_6385316_9 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000003522 175.0
TLS3_k127_6385685_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 430.0
TLS3_k127_6385685_1 Integral membrane - - - 0.0000000000003516 76.0
TLS3_k127_6390929_0 DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 337.0
TLS3_k127_6390929_1 Chlorophyllase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000334 231.0
TLS3_k127_6390929_2 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000001763 213.0
TLS3_k127_6390929_3 Belongs to the FPG family K05522 - 4.2.99.18 0.00000000000000000000000000003172 128.0
TLS3_k127_6390929_4 Trehalase K01194 - 3.2.1.28 0.000000126 56.0
TLS3_k127_6390929_5 Transposase - - - 0.000005682 48.0
TLS3_k127_6397873_0 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000002919 84.0
TLS3_k127_6404749_0 - - - - 0.000000000000000000000000000000000000000000000000000001294 199.0
TLS3_k127_6404749_1 resistance protein K14166 - - 0.0000000000000000000000000000002735 139.0
TLS3_k127_6404749_2 Winged helix-turn-helix DNA-binding - - - 0.000000000000007002 81.0
TLS3_k127_6404749_3 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000002355 78.0
TLS3_k127_6404749_5 COG COG3293 Transposase and inactivated derivatives - - - 0.000000000008874 66.0
TLS3_k127_6404749_6 - - - - 0.00000000009297 68.0
TLS3_k127_6404749_7 endonuclease - - - 0.00000002945 57.0
TLS3_k127_6404749_8 Copper resistance protein K07156 - - 0.00000778 57.0
TLS3_k127_6404749_9 SPTR Transposase, IS4 family protein - - - 0.00001663 48.0
TLS3_k127_6404926_0 Large family of predicted nucleotide-binding domains K06865 - - 2.268e-201 646.0
TLS3_k127_6404926_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 362.0
TLS3_k127_6408886_0 fumarate reductase flavoprotein K00239 - 1.3.5.1,1.3.5.4 1.13e-297 920.0
TLS3_k127_6408886_1 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 2.286e-279 868.0
TLS3_k127_6408886_10 Oxidoreductase family, NAD-binding Rossmann fold K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 405.0
TLS3_k127_6408886_11 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 362.0
TLS3_k127_6408886_12 Protein of unknown function (DUF354) K09726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009101 360.0
TLS3_k127_6408886_13 cation diffusion facilitator family transporter K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007139 294.0
TLS3_k127_6408886_14 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005603 279.0
TLS3_k127_6408886_15 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000008069 233.0
TLS3_k127_6408886_16 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000000000000000000000000000000000000000000001711 224.0
TLS3_k127_6408886_17 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000007395 204.0
TLS3_k127_6408886_18 Mn2 -dependent serine threonine protein kinase K08851 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000003424 199.0
TLS3_k127_6408886_19 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000001276 193.0
TLS3_k127_6408886_2 GTPase of unknown function C-terminal K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 502.0
TLS3_k127_6408886_20 Nicotinamide-nucleotide adenylyltransferase - - - 0.000000000000000000000000000000000000000000000000000355 192.0
TLS3_k127_6408886_21 Iron-sulfur cluster assembly protein - - - 0.000000000000000000000000000000000000000000000002464 175.0
TLS3_k127_6408886_22 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) K05967 - - 0.00000000000000000000000000000000000000000000001419 177.0
TLS3_k127_6408886_23 Thioredoxin K03671 - - 0.00000000000000000000000000000000000000000000001444 173.0
TLS3_k127_6408886_24 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000000000000000000012 150.0
TLS3_k127_6408886_25 Acetyltransferase (GNAT) domain K00621 - 2.3.1.4 0.00000000000000000000000000000000004583 140.0
TLS3_k127_6408886_26 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.0000000000000000000000000000000001032 134.0
TLS3_k127_6408886_27 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.000000000000000000000000000000002465 132.0
TLS3_k127_6408886_28 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000003628 133.0
TLS3_k127_6408886_29 Binds to the 23S rRNA K02896 - - 0.0000000000000000000000000000004575 122.0
TLS3_k127_6408886_3 Belongs to the phosphohexose mutase family K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 468.0
TLS3_k127_6408886_30 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000000000000000000597 121.0
TLS3_k127_6408886_31 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.0000000000000000000000000003383 114.0
TLS3_k127_6408886_33 response regulator, receiver K07668,K07669 - - 0.000000000000000000006441 97.0
TLS3_k127_6408886_35 - - - - 0.000000000000004356 79.0
TLS3_k127_6408886_36 - - - - 0.00000000001711 66.0
TLS3_k127_6408886_4 argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000878 459.0
TLS3_k127_6408886_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 451.0
TLS3_k127_6408886_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006033 426.0
TLS3_k127_6408886_7 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 424.0
TLS3_k127_6408886_8 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 413.0
TLS3_k127_6408886_9 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005399 424.0
TLS3_k127_6415738_0 Radical SAM K18285 - 2.5.1.120 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 529.0
TLS3_k127_6415738_1 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 490.0
TLS3_k127_6415738_2 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007852 298.0
TLS3_k127_6415738_3 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 0.000000000004386 66.0
TLS3_k127_6430930_0 Major facilitator superfamily K08151 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 449.0
TLS3_k127_6430930_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000003344 191.0
TLS3_k127_6430930_2 Antibiotic biosynthesis monooxygenase - - - 0.00000001981 60.0
TLS3_k127_6432552_0 - - - - 0.000000002298 64.0
TLS3_k127_6451686_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00034 - 1.1.1.47 0.000000000000000000000000000000000000000000000000000000000000000000002383 244.0
TLS3_k127_6451686_1 alpha,alpha-trehalase activity K03931 GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716 - 0.0000000000000000000000000000000000000000000000000000000000001269 218.0
TLS3_k127_6496201_0 - - - - 0.000000000000000000000000000000000000000000000000000000000001819 215.0
TLS3_k127_6496201_1 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000002441 207.0
TLS3_k127_6496201_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000008858 181.0
TLS3_k127_650866_0 Domain of unknown function (DUF1731) K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 361.0
TLS3_k127_650866_1 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000002711 205.0
TLS3_k127_650866_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000001263 136.0
TLS3_k127_650866_3 His Kinase A (phosphoacceptor) domain - - - 0.000003595 56.0
TLS3_k127_6537245_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 395.0
TLS3_k127_6537245_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004644 249.0
TLS3_k127_6541440_0 beta-lactamase superfamily II K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000004676 207.0
TLS3_k127_6541440_1 Putative methyltransferase - - - 0.000000000000003576 77.0
TLS3_k127_6541440_2 PFAM beta-lactamase domain protein K06897 - 2.5.1.105 0.000000001509 59.0
TLS3_k127_6564937_1 Domain of unknown function (DUF4359) - - - 0.000000000000000000000000001066 116.0
TLS3_k127_6586186_0 S-adenosylmethionine synthetase K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006097 584.0
TLS3_k127_6586186_1 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009813 434.0
TLS3_k127_6586186_2 snRNP Sm proteins K04796 - - 0.0000000000000000000000000000000001054 134.0
TLS3_k127_6586186_3 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.000000000000005172 77.0
TLS3_k127_6586186_4 RecA RadA K04482,K04483 - - 0.000000001229 67.0
TLS3_k127_6590278_0 Alpha/beta hydrolase family K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 325.0
TLS3_k127_6590278_1 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001436 267.0
TLS3_k127_6593149_0 cytochrome p450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 332.0
TLS3_k127_6593149_1 TPR Domain containing protein - - - 0.00000000000000000000000001499 119.0
TLS3_k127_660373_0 zinc finger BED domain-containing protein - - - 0.000000000000000000000000002502 123.0
TLS3_k127_660373_2 RNA polymerase II regulatory region DNA binding - GO:0000228,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0000982,GO:0000987,GO:0001012,GO:0001067,GO:0001077,GO:0001228,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0004803,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006464,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016740,GO:0016925,GO:0018130,GO:0018193,GO:0018205,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019787,GO:0019789,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031974,GO:0031981,GO:0032446,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045893,GO:0045935,GO:0045944,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070013,GO:0070647,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140096,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000009966 100.0
TLS3_k127_6615196_0 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000002255 231.0
TLS3_k127_6615196_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000003518 196.0
TLS3_k127_6615196_2 Homeodomain-like domain - - - 0.00000003288 61.0
TLS3_k127_6615196_3 Winged helix-turn helix - - - 0.000001247 56.0
TLS3_k127_6621049_0 Erythromycin esterase K06880 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 486.0
TLS3_k127_6621049_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134,K00150 - 1.2.1.12,1.2.1.59 0.0000000000000000004338 87.0
TLS3_k127_6621049_2 Transposase and inactivated derivatives - - - 0.000000000000000805 80.0
TLS3_k127_6621049_3 Transposase and inactivated derivatives - - - 0.00000000000001449 79.0
TLS3_k127_6629777_0 PFAM Ferritin, Dps family protein K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000000001406 196.0
TLS3_k127_6629777_1 PFAM transposase, IS4 family protein - - - 0.000000000000000000000000000000002043 134.0
TLS3_k127_6629777_2 This gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.00000000000000002409 86.0
TLS3_k127_6635629_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 454.0
TLS3_k127_6635629_1 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 434.0
TLS3_k127_6635629_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000006104 146.0
TLS3_k127_6635629_3 - - - - 0.000000000000000005281 83.0
TLS3_k127_6635629_4 Transcriptional regulator - - - 0.000000000000001762 81.0
TLS3_k127_6637102_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 464.0
TLS3_k127_6637102_1 mechanosensitive ion channel - - - 0.000000000000000000000000000001802 132.0
TLS3_k127_6640695_1 - - - - 0.000000000000000223 94.0
TLS3_k127_6659624_0 PFAM regulatory protein, ArsR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007804 441.0
TLS3_k127_6659624_1 - - - - 0.000001783 52.0
TLS3_k127_6667703_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000008514 269.0
TLS3_k127_6676827_0 Methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000002558 223.0
TLS3_k127_6725528_0 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000009398 184.0
TLS3_k127_6725528_1 Tetratricopeptide repeat - - - 0.0001765 46.0
TLS3_k127_6795492_1 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004996 255.0
TLS3_k127_680567_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000001095 118.0
TLS3_k127_6811344_0 - - - - 0.0000000000000000000000000000000001536 142.0
TLS3_k127_6829112_0 COG3546 Mn-containing catalase K07217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009685 399.0
TLS3_k127_6847761_0 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004826 271.0
TLS3_k127_6847761_1 - - - - 0.0000000000000000005903 91.0
TLS3_k127_6847761_2 membrane protein domain - - - 0.0000000002015 69.0
TLS3_k127_6867292_0 Alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 371.0
TLS3_k127_6874136_0 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.0000000000000000000000000000000000000000000000008821 185.0
TLS3_k127_6874136_1 ribonuclease H protein At1g65750 - - - 0.0000000005644 66.0
TLS3_k127_6874136_2 ribonuclease H protein At1g65750 - - - 0.000000001038 60.0
TLS3_k127_6879282_0 multicopper - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 470.0
TLS3_k127_6879282_2 - - - - 0.00000000000000006242 89.0
TLS3_k127_6893083_0 of nitrite reductase and ring-hydroxylating K05710 - - 0.000000048 55.0
TLS3_k127_6899622_0 PFAM GCN5-related N-acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000000000000000000000001933 244.0
TLS3_k127_6899622_1 COG3316 Transposase and inactivated derivatives - - - 0.00000000001078 73.0
TLS3_k127_6900565_0 PFAM GCN5-related N-acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000000000000000242 254.0
TLS3_k127_6900565_1 PFAM Integrase core domain - - - 0.0000006786 58.0
TLS3_k127_6900565_2 leucine-zipper of insertion element IS481 - - - 0.0001502 51.0
TLS3_k127_6900913_0 Multicopper oxidase type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 484.0
TLS3_k127_6900913_1 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004647 245.0
TLS3_k127_6901703_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1077.0
TLS3_k127_6901703_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 572.0
TLS3_k127_6901703_2 PFAM Isochorismatase - - - 0.00000000000000000000000000000000000000000002291 166.0
TLS3_k127_6901703_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000001676 143.0
TLS3_k127_6901703_4 PFAM CBS domain containing protein - - - 0.00000000000000000000005964 104.0
TLS3_k127_6902856_0 Alpha mannosidase, middle domain K01191 - 3.2.1.24 1.072e-221 717.0
TLS3_k127_6902856_1 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 2.033e-200 643.0
TLS3_k127_6902856_11 IclR helix-turn-helix domain - - - 0.00002294 51.0
TLS3_k127_6902856_2 NurA - - - 0.0000000000000000000000000000000000000000000000000000000000004392 221.0
TLS3_k127_6902856_3 - - - - 0.00000000000000000000000001099 112.0
TLS3_k127_6902856_4 Peptidase family M23 - - - 0.000000000000000000001561 99.0
TLS3_k127_6902856_7 - - - - 0.00000000008752 65.0
TLS3_k127_6902856_8 - - - - 0.0000000001545 68.0
TLS3_k127_6902856_9 multicopper - - - 0.000000003174 68.0
TLS3_k127_6927179_0 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000005875 91.0
TLS3_k127_6927179_1 Hemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000000006922 82.0
TLS3_k127_6957592_0 Sodium:sulfate symporter transmembrane region K14445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000334 596.0
TLS3_k127_6957592_1 Sodium hydrogen exchanger K03455 - - 0.0000000000000003253 81.0
TLS3_k127_6957592_2 - - - - 0.0000000001049 66.0
TLS3_k127_6971008_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006415 491.0
TLS3_k127_6971008_1 PFAM SPFH domain Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 355.0
TLS3_k127_6971008_2 iron dependent repressor - - - 0.00000000000000000000000009897 108.0
TLS3_k127_6974150_0 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily K08698 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 318.0
TLS3_k127_6974150_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000003286 184.0
TLS3_k127_6974150_2 COG3325 Chitinase K01183 - 3.2.1.14 0.000000006555 66.0
TLS3_k127_6974150_3 PFAM Transposase DDE domain - - - 0.0000003369 62.0
TLS3_k127_6977667_0 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 409.0
TLS3_k127_6977667_1 Universal stress protein - - - 0.0000000000000000000000000000009303 125.0
TLS3_k127_6977667_2 Isochorismatase family - - - 0.00002068 48.0
TLS3_k127_701838_0 Multicopper oxidase, type 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 372.0
TLS3_k127_701838_1 Lactonase, 7-bladed beta-propeller - - - 0.000000000000000000000000000000002411 147.0
TLS3_k127_702912_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 310.0
TLS3_k127_702912_1 TIGRFAM tungstate ABC transporter binding protein WtpA K15495 - - 0.00000000000000000000000000000000000000000000000000001679 199.0
TLS3_k127_702912_2 Protein tyrosine kinase - - - 0.00001884 48.0
TLS3_k127_7032269_0 AAA domain (Cdc48 subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008749 572.0
TLS3_k127_7032269_1 Sugar-specific transcriptional regulator TrmB - - - 0.0000000000000000000000000000000000000000002204 169.0
TLS3_k127_7032269_2 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000001445 158.0
TLS3_k127_7032269_3 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.0000000000000000000000000000000002806 135.0
TLS3_k127_7047879_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K15510,K21835 - 1.1.98.2,1.1.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 419.0
TLS3_k127_7047879_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 346.0
TLS3_k127_7047879_2 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000003839 241.0
TLS3_k127_7047879_3 Glycosyltransferase Family 4 - - - 0.0000007764 55.0
TLS3_k127_7047879_4 tripartite motif containing 71, E3 ubiquitin protein ligase K12035 GO:0000003,GO:0000082,GO:0000278,GO:0000932,GO:0001708,GO:0001838,GO:0001841,GO:0001843,GO:0002009,GO:0002164,GO:0002165,GO:0002168,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005912,GO:0005924,GO:0005927,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006417,GO:0006464,GO:0006725,GO:0006807,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007276,GO:0007399,GO:0007517,GO:0007548,GO:0008150,GO:0008152,GO:0008283,GO:0008543,GO:0008544,GO:0009056,GO:0009057,GO:0009653,GO:0009719,GO:0009790,GO:0009791,GO:0009792,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009913,GO:0009957,GO:0009987,GO:0010033,GO:0010171,GO:0010172,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010586,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0010720,GO:0014020,GO:0014070,GO:0016070,GO:0016071,GO:0016203,GO:0016331,GO:0016441,GO:0016458,GO:0016567,GO:0016740,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0019538,GO:0019787,GO:0019953,GO:0021915,GO:0022402,GO:0022407,GO:0022414,GO:0023052,GO:0030054,GO:0030055,GO:0030154,GO:0030155,GO:0030371,GO:0030674,GO:0030855,GO:0030856,GO:0031047,GO:0031050,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031329,GO:0031331,GO:0032268,GO:0032269,GO:0032446,GO:0032501,GO:0032502,GO:0032504,GO:0032991,GO:0033628,GO:0033632,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0035148,GO:0035194,GO:0035195,GO:0035196,GO:0035198,GO:0035239,GO:0035278,GO:0035295,GO:0035770,GO:0036211,GO:0036464,GO:0040029,GO:0040033,GO:0040034,GO:0042127,GO:0042221,GO:0043009,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043331,GO:0043412,GO:0043487,GO:0043488,GO:0043900,GO:0043902,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044344,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0044706,GO:0044770,GO:0044772,GO:0044843,GO:0045138,GO:0045165,GO:0045182,GO:0045595,GO:0045597,GO:0045604,GO:0045682,GO:0045935,GO:0045974,GO:0046483,GO:0046661,GO:0046700,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048598,GO:0048609,GO:0048646,GO:0048729,GO:0048731,GO:0048856,GO:0048869,GO:0050779,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051171,GO:0051172,GO:0051173,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051704,GO:0051716,GO:0051865,GO:0060090,GO:0060147,GO:0060148,GO:0060255,GO:0060281,GO:0060282,GO:0060284,GO:0060378,GO:0060429,GO:0060538,GO:0060562,GO:0060606,GO:0060964,GO:0060966,GO:0060968,GO:0061013,GO:0061014,GO:0061061,GO:0061157,GO:0061158,GO:0061630,GO:0061659,GO:0061980,GO:0065007,GO:0065008,GO:0070161,GO:0070647,GO:0070848,GO:0070887,GO:0070918,GO:0071310,GO:0071359,GO:0071363,GO:0071407,GO:0071495,GO:0071704,GO:0071774,GO:0072089,GO:0072175,GO:0080090,GO:0090304,GO:0090598,GO:0090727,GO:0097159,GO:0140096,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901575,GO:1901698,GO:1901699,GO:1903047,GO:1903311,GO:1903313,GO:1905879,GO:1905881,GO:1990124,GO:1990904,GO:2000026,GO:2000112,GO:2000113,GO:2000177,GO:2000241,GO:2000243,GO:2000637 2.3.2.27 0.00001208 48.0
TLS3_k127_7048900_0 Cytochrome b subunit of the bc complex K00412 - - 2.713e-235 741.0
TLS3_k127_7048900_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 577.0
TLS3_k127_7048900_10 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001493 265.0
TLS3_k127_7048900_11 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000346 243.0
TLS3_k127_7048900_12 Cobalamin B12-binding domain protein K16955,K22491 - - 0.000000000000000000000000000000000000000000000000000000000000003256 228.0
TLS3_k127_7048900_13 ribosomal protein K02956 - - 0.0000000000000000000000000000000000000000000000000000005335 196.0
TLS3_k127_7048900_14 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.0000000000000000000000000000000000000000000000003319 179.0
TLS3_k127_7048900_15 - - - - 0.00000000000000000000000000000000000000000001033 169.0
TLS3_k127_7048900_16 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000004494 164.0
TLS3_k127_7048900_17 - - - - 0.00000000000000000000000000000000000216 141.0
TLS3_k127_7048900_18 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.0000000000000000000000000000000006283 134.0
TLS3_k127_7048900_19 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000006969 128.0
TLS3_k127_7048900_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008062 552.0
TLS3_k127_7048900_20 DHHA1 domain K07463 - - 0.000000000000000000000000000005325 136.0
TLS3_k127_7048900_21 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.000000000000000000000000000006989 121.0
TLS3_k127_7048900_22 - - - - 0.00000000000000000000000000007188 119.0
TLS3_k127_7048900_23 Protein of unknown function DUF126 K09128 - - 0.000000000000000000000000001641 117.0
TLS3_k127_7048900_24 zinc finger - - - 0.0000000000000000000000001988 108.0
TLS3_k127_7048900_25 - - - - 0.00000000000000000000522 99.0
TLS3_k127_7048900_26 - - - - 0.000000000000000000008631 93.0
TLS3_k127_7048900_28 - - - - 0.0000000000000000004379 87.0
TLS3_k127_7048900_29 RNA polymerase Rpb3/Rpb11 dimerisation domain K03056 - 2.7.7.6 0.000000000000000005394 89.0
TLS3_k127_7048900_3 PFAM tRNA synthetase, class II (D, K and N) K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000658 529.0
TLS3_k127_7048900_30 PFAM Rieske 2Fe-2S domain - - - 0.00000000001764 72.0
TLS3_k127_7048900_31 Transcriptional regulator - - - 0.00000000009022 66.0
TLS3_k127_7048900_32 - - - - 0.000000003597 65.0
TLS3_k127_7048900_33 zinc finger - - - 0.0000001646 54.0
TLS3_k127_7048900_34 Protein of unknown function (DUF763) K09003 - - 0.0000005461 53.0
TLS3_k127_7048900_35 - - - - 0.000002045 57.0
TLS3_k127_7048900_36 cheY-homologous receiver domain K03413 - - 0.00000293 54.0
TLS3_k127_7048900_37 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K15510,K21835 - 1.1.98.2,1.1.98.5 0.00006212 48.0
TLS3_k127_7048900_38 Transcription factor Pcc1 - - - 0.000695 46.0
TLS3_k127_7048900_4 malic enzyme K00027,K00029 - 1.1.1.38,1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005596 522.0
TLS3_k127_7048900_5 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 433.0
TLS3_k127_7048900_6 PP-loop family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 402.0
TLS3_k127_7048900_7 NAD-dependent epimerase dehydratase K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 405.0
TLS3_k127_7048900_8 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 361.0
TLS3_k127_7048900_9 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006157 346.0
TLS3_k127_7051950_0 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005267 535.0
TLS3_k127_7076120_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007868 442.0
TLS3_k127_7099979_0 CBS domain K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 404.0
TLS3_k127_7099979_1 COG1335 Amidases related to nicotinamidase K09020 - 3.5.1.110 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 285.0
TLS3_k127_7108076_0 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.000000000000000000000000000000000000000000000000002991 194.0
TLS3_k127_7108076_1 integrase family - - - 0.0000000000000000000000000009785 116.0
TLS3_k127_7108076_2 integrase family - - - 0.00000000000000000000000001734 115.0
TLS3_k127_7108076_3 - - - - 0.000000000000000006816 88.0
TLS3_k127_7108076_4 integrase family - - - 0.00000000000000009939 84.0
TLS3_k127_7143198_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 291.0
TLS3_k127_7143198_1 - - - - 0.0000000000000000000000119 105.0
TLS3_k127_715157_0 Sulfite reductase K00392 - 1.8.7.1 2.471e-261 817.0
TLS3_k127_715157_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005401 527.0
TLS3_k127_715157_10 Belongs to the UPF0201 family K09736 - - 0.0000000000000000005891 92.0
TLS3_k127_715157_11 Thioredoxin - - - 0.0000000009289 61.0
TLS3_k127_715157_2 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 514.0
TLS3_k127_715157_3 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 370.0
TLS3_k127_715157_4 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005814 339.0
TLS3_k127_715157_5 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003229 284.0
TLS3_k127_715157_6 DJ-1/PfpI family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002092 277.0
TLS3_k127_715157_7 AAA domain - - - 0.0000000000000000000000000000000000000000000000000131 186.0
TLS3_k127_715157_8 Ser thr protein kinase K07176 - - 0.00000000000000000000000000000000000007082 152.0
TLS3_k127_715157_9 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000003688 109.0
TLS3_k127_7154287_2 with the alpha beta hydrolase fold - - - 0.000439 51.0
TLS3_k127_7157311_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000954 499.0
TLS3_k127_7157311_1 - - - - 0.00000000000000000000000000000000001473 150.0
TLS3_k127_7170751_0 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000007269 115.0
TLS3_k127_7170751_1 Sodium hydrogen exchanger K03455 - - 0.000000000000000000002805 94.0
TLS3_k127_7170751_2 - - - - 0.0000000004926 64.0
TLS3_k127_7170751_4 - - - - 0.00002259 49.0
TLS3_k127_7170751_5 Sodium hydrogen exchanger K03455 - - 0.0003504 43.0
TLS3_k127_7173050_0 ChaB K06197 - - 0.00000000000000001249 85.0
TLS3_k127_7188524_0 Domain of unknown function (DUF373) K08975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 421.0
TLS3_k127_7188524_1 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007132 352.0
TLS3_k127_7190477_0 TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006358 374.0
TLS3_k127_7190477_1 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050 - - 0.000002602 49.0
TLS3_k127_7191176_0 - - - - 7.168e-195 616.0
TLS3_k127_7191176_1 Purple acid Phosphatase, N-terminal domain - - - 0.0000000000000000007349 98.0
TLS3_k127_7191176_2 COG2931, RTX toxins and related Ca2 -binding proteins K01406 - 3.4.24.40 0.0000000000000009286 83.0
TLS3_k127_7191176_3 COG3316 Transposase and inactivated derivatives - - - 0.0000002918 57.0
TLS3_k127_7192894_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 8.463e-200 648.0
TLS3_k127_7192894_1 universal stress protein - - - 0.000000000000000000002934 98.0
TLS3_k127_7192894_2 - - - - 0.0000000000000000000676 93.0
TLS3_k127_7192894_3 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000003691 51.0
TLS3_k127_719336_0 - - - - 0.000004001 54.0
TLS3_k127_7205037_0 COG3316 Transposase and inactivated derivatives K07498 - - 0.000000725 55.0
TLS3_k127_7229606_0 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003478 286.0
TLS3_k127_7229606_1 Subtilase family K14645 - - 0.00000000000000000000000000000000000000000000000000000000000000006774 243.0
TLS3_k127_7229606_2 Amino acid kinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000003717 219.0
TLS3_k127_7229606_3 Domain of unknown function (DUF2024) - - - 0.000000000000000000000000000000000000000003895 155.0
TLS3_k127_7229618_0 TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 323.0
TLS3_k127_7229618_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000008311 182.0
TLS3_k127_7237630_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006749 378.0
TLS3_k127_7237630_1 pfkB family carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 332.0
TLS3_k127_7237630_10 - - - - 0.0000000000000000000000000000000000000000003132 161.0
TLS3_k127_7237630_11 - - - - 0.00000000000000000005235 92.0
TLS3_k127_7237630_12 - - - - 0.0000000000000006955 83.0
TLS3_k127_7237630_13 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000001764 59.0
TLS3_k127_7237630_14 Kinase binding protein CGI-121 - - - 0.0000001183 56.0
TLS3_k127_7237630_2 Vinylacetyl-CoA Delta-isomerase K14534 - 4.2.1.120,5.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000674 295.0
TLS3_k127_7237630_3 Glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000004771 265.0
TLS3_k127_7237630_4 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000001314 252.0
TLS3_k127_7237630_5 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000004528 243.0
TLS3_k127_7237630_6 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000003799 219.0
TLS3_k127_7237630_7 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000003885 216.0
TLS3_k127_7237630_8 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000003436 209.0
TLS3_k127_7237630_9 K homology RNA-binding domain K06961 - - 0.000000000000000000000000000000000000000000000000001388 188.0
TLS3_k127_7248822_0 Protein of unknown function DUF72 - - - 0.00000006154 56.0
TLS3_k127_7248911_0 PFAM 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003925 274.0
TLS3_k127_7248911_1 Iron-containing redox enzyme K06137 - 1.3.3.11 0.000000000000000000000000000000000000000000000000000001936 199.0
TLS3_k127_7248911_2 of nitrite reductase and ring-hydroxylating K05710 - - 0.00000000000000000000000000000000000004328 144.0
TLS3_k127_7248911_3 Helix-turn-helix of DDE superfamily endonuclease - - - 0.000000000008643 72.0
TLS3_k127_7248911_4 Belongs to the universal stress protein A family - - - 0.0000006492 53.0
TLS3_k127_7248911_5 PFAM transposase, IS4 family protein - - - 0.0003504 44.0
TLS3_k127_7248911_6 SEC-C Motif Domain Protein - - - 0.000926 52.0
TLS3_k127_7250012_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.000000000000000000000000000000000000000000000000001851 191.0
TLS3_k127_7250012_1 Belongs to the peptidase M50B family - GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.0000000000000000000000000000002062 126.0
TLS3_k127_7250012_2 Belongs to the peptidase M50B family - GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.0000000000000000000000000002593 124.0
TLS3_k127_7250012_3 SPTR Transposase, IS4 family protein - - - 0.00002135 48.0
TLS3_k127_7250012_4 Belongs to the peptidase M50B family - - - 0.0000428 51.0
TLS3_k127_7257207_0 protein conserved in archaea - - - 0.000000000000000000000000002299 118.0
TLS3_k127_7257207_1 Universal stress protein - - - 0.00000000000706 73.0
TLS3_k127_7261389_0 Protocatechuate 3,4-dioxygenase beta subunit - - - 0.00000000000000000000000000001211 122.0
TLS3_k127_7261389_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000003141 124.0
TLS3_k127_7261389_2 - - - - 0.000000000000000000000000001303 115.0
TLS3_k127_7261389_4 hydrolase, acting on ester bonds methyl indole-3-acetate esterase methyl jasmonate esterase methyl salicylate esterase - GO:0002376,GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009620,GO:0009627,GO:0009696,GO:0009814,GO:0009817,GO:0009987,GO:0010817,GO:0016787,GO:0016788,GO:0016999,GO:0017144,GO:0018958,GO:0019752,GO:0032787,GO:0042445,GO:0042537,GO:0043207,GO:0043436,GO:0044237,GO:0044281,GO:0045087,GO:0050832,GO:0050896,GO:0051704,GO:0051707,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0080030,GO:0080031,GO:0080032,GO:0098542,GO:1901360,GO:1901615 - 0.000001536 51.0
TLS3_k127_7268664_0 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009525 292.0
TLS3_k127_7268664_1 PFAM Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002226 267.0
TLS3_k127_7268664_2 SNARE associated Golgi protein - - - 0.00000000000000000000000000000001725 134.0
TLS3_k127_7268664_3 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000003491 120.0
TLS3_k127_7268664_4 Cytochrome P450 - - - 0.0000000000000000000001247 102.0
TLS3_k127_7268664_6 Transposase K07497 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0005947 49.0
TLS3_k127_7270060_0 PFAM Insertion element protein K07488 - - 0.000000000000002075 84.0
TLS3_k127_7270060_1 Transposase and inactivated derivatives - - - 0.0000000000001542 73.0
TLS3_k127_7272868_0 - - - - 0.00004667 52.0
TLS3_k127_7283897_0 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.00000000000000000000007556 102.0
TLS3_k127_7292562_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 396.0
TLS3_k127_7292562_1 Nitroreductase - - - 0.0000000000000000000000002173 108.0
TLS3_k127_7292562_2 protein conserved in archaea - - - 0.00000004959 61.0
TLS3_k127_7379140_0 Mg2 transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 344.0
TLS3_k127_7379140_1 Belongs to the UPF0255 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 338.0
TLS3_k127_7379140_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 301.0
TLS3_k127_7379140_3 SPTR Transposase, IS4 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001027 238.0
TLS3_k127_7379140_4 zinc finger - - - 0.0000000000000000000000000000000000000000000000000000000000000001008 230.0
TLS3_k127_7379140_5 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000002772 216.0
TLS3_k127_7379140_6 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000004354 153.0
TLS3_k127_7379140_7 - - - - 0.000000000000005922 79.0
TLS3_k127_7379140_8 Transcriptional regulatory protein, C terminal K18144 - - 0.0002151 49.0
TLS3_k127_7379140_9 Alternative locus ID K15383 - - 0.0005953 46.0
TLS3_k127_7382377_0 Amino acid kinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006081 389.0
TLS3_k127_7382377_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006419 377.0
TLS3_k127_7382377_2 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 301.0
TLS3_k127_7390756_0 DoxX family K15977,K16937 - 1.8.5.2 0.0000000000002729 74.0
TLS3_k127_7424760_0 Vinylacetyl-CoA Delta-isomerase K14534 - 4.2.1.120,5.3.3.3 3.347e-205 642.0
TLS3_k127_7424760_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 480.0
TLS3_k127_7426167_0 Mg2 transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 331.0
TLS3_k127_7430723_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 1.034e-288 894.0
TLS3_k127_7430723_1 PFAM Alcohol dehydrogenase GroES-like domain - - - 1.026e-199 625.0
TLS3_k127_7430723_10 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000007114 264.0
TLS3_k127_7430723_11 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.000000000000000000000000000000000000000000000000000000000000000000004223 236.0
TLS3_k127_7430723_12 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000001467 237.0
TLS3_k127_7430723_13 Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity K08096 - 3.5.4.29 0.00000000000000000000000000000000000000000000000000000000001579 215.0
TLS3_k127_7430723_14 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000008325 210.0
TLS3_k127_7430723_15 Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA K14568 - 2.1.1.260 0.0000000000000000000000000000000000000000000000000002934 193.0
TLS3_k127_7430723_16 riboflavin synthase, alpha K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000001523 190.0
TLS3_k127_7430723_17 thioesterase - - - 0.000000000000000000000000000000000000000000000002114 177.0
TLS3_k127_7430723_18 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000178 171.0
TLS3_k127_7430723_19 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000001709 165.0
TLS3_k127_7430723_2 aspartate-semialdehyde dehydrogenase K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 564.0
TLS3_k127_7430723_20 Binds to the 23S rRNA K02929 - - 0.00000000000000000000000000000000000000000138 158.0
TLS3_k127_7430723_21 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000003613 142.0
TLS3_k127_7430723_22 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.0000000000000000000000000000000004862 134.0
TLS3_k127_7430723_23 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000000000009932 126.0
TLS3_k127_7430723_24 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.0000000000000000000003893 100.0
TLS3_k127_7430723_25 Nucleotidyl transferase K19712 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008820,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019438,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0070568,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.7.62 0.000000000000002114 85.0
TLS3_k127_7430723_26 PFAM ribosomal protein K02978 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000001412 66.0
TLS3_k127_7430723_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 450.0
TLS3_k127_7430723_4 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 451.0
TLS3_k127_7430723_5 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 298.0
TLS3_k127_7430723_6 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 293.0
TLS3_k127_7430723_7 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000381 280.0
TLS3_k127_7430723_8 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004501 280.0
TLS3_k127_7430723_9 Lrp/AsnC ligand binding domain K03718 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001443 256.0
TLS3_k127_7442041_0 Ion channel K10716 GO:0003674,GO:0005215,GO:0005216,GO:0005244,GO:0005249,GO:0005261,GO:0005267,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022832,GO:0022836,GO:0022838,GO:0022839,GO:0022843,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 0.0000000002231 68.0
TLS3_k127_7442041_1 - - - - 0.000000006061 67.0
TLS3_k127_7459400_0 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000001621 205.0
TLS3_k127_7459403_0 Galactose oxidase, central domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 322.0
TLS3_k127_7459403_1 integrase family - - - 0.000000000007065 74.0
TLS3_k127_7462310_0 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000003622 192.0
TLS3_k127_7462310_1 PFAM regulatory protein TetR K03577,K18939 - - 0.00000000000000000000000000000000000000000002621 168.0
TLS3_k127_7462310_2 Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD( ) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) K02472 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 1.1.1.336 0.0005464 46.0
TLS3_k127_7502793_0 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 8.775e-224 712.0
TLS3_k127_7502793_1 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000001607 182.0
TLS3_k127_7510865_0 NADH dehydrogenase K03885 GO:0003674,GO:0003824,GO:0003955,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0044237,GO:0045333,GO:0055114 1.6.99.3 0.000000000000000000000000000000000000000000000001833 188.0
TLS3_k127_7512605_0 ISXO2-like transposase domain K07488 - - 0.0000000000000000000000000000000000000000000000009137 185.0
TLS3_k127_7512605_1 Belongs to the P(II) protein family K04751 - - 0.0000000000000005187 82.0
TLS3_k127_7513357_0 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000002187 174.0
TLS3_k127_7513357_1 OsmC-like protein - - - 0.0000002931 52.0
TLS3_k127_7514724_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 592.0
TLS3_k127_7514724_1 Tyrosine--tRNA ligase K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 469.0
TLS3_k127_7514724_2 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000183 191.0
TLS3_k127_7514724_3 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000004235 179.0
TLS3_k127_7514724_4 - - - - 0.0000000000007448 77.0
TLS3_k127_7537575_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003192 247.0
TLS3_k127_7537575_1 Peptidase inhibitor I9 - - - 0.0000000000000000000000004215 110.0
TLS3_k127_7537575_2 Dodecin K09165 - - 0.00000000006736 65.0
TLS3_k127_7541147_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002174 562.0
TLS3_k127_7541147_1 Phenylalanyl-tRNA synthetase alpha subunit K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009889 496.0
TLS3_k127_7541147_2 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000001411 274.0
TLS3_k127_7541147_3 ferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000002124 219.0
TLS3_k127_7541147_4 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000000000002499 165.0
TLS3_k127_7541147_5 Cytidylyltransferase-like K02201 - 2.7.7.3 0.0000000000000000000000000000000000000509 147.0
TLS3_k127_7541147_6 - - - - 0.0000000000000000000000000000008343 124.0
TLS3_k127_7541147_7 - - - - 0.00000000000004773 76.0
TLS3_k127_7575801_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 389.0
TLS3_k127_7582579_1 response regulator, receiver - - - 0.00000000000004866 77.0
TLS3_k127_7582579_2 Ion transport protein K08714 - - 0.000000000004869 70.0
TLS3_k127_7582579_3 pyridoxamine 5-phosphate K07005 - - 0.00000006263 54.0
TLS3_k127_7599669_0 CBS domain K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 581.0
TLS3_k127_7599669_1 Sodium hydrogen exchanger - - - 0.00000000000000001749 83.0
TLS3_k127_7599669_2 Arsenical pump membrane protein - - - 0.0000000000000001034 84.0
TLS3_k127_7599669_3 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000007014 52.0
TLS3_k127_7674113_0 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000121 192.0
TLS3_k127_7674113_1 integrase family - - - 0.0001291 46.0
TLS3_k127_7693712_0 Type III restriction enzyme, res subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 459.0
TLS3_k127_7693712_1 Plasmid pRiA4b ORF-3-like protein - - - 0.000000000000000000003568 98.0
TLS3_k127_7714684_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000002077 145.0
TLS3_k127_7714684_2 Transcriptional regulator - - - 0.000000000000001413 80.0
TLS3_k127_7715125_0 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 578.0
TLS3_k127_7730019_0 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000001866 200.0
TLS3_k127_7730019_1 OsmC-like protein - - - 0.000000000000000000000004397 108.0
TLS3_k127_7764760_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 368.0
TLS3_k127_7764760_1 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 338.0
TLS3_k127_7764760_10 - - - - 0.00000000002502 71.0
TLS3_k127_7764760_11 transferase activity, transferring acyl groups - - - 0.000000001014 66.0
TLS3_k127_7764760_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 308.0
TLS3_k127_7764760_3 Acetyltransferase (GNAT) domain K22479 - - 0.000000000000000000000000000000000000000000000000002068 188.0
TLS3_k127_7764760_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.00000000000000000000000000000000000000000000000002109 183.0
TLS3_k127_7764760_5 Pyridoxamine 5'-phosphate - - - 0.00000000000000000000000000000000000009125 145.0
TLS3_k127_7764760_6 PPIC-type PPIASE domain K07533 - 5.2.1.8 0.000000000000000000000000000000000000746 141.0
TLS3_k127_7764760_7 - - - - 0.00000000000000000000000000002351 122.0
TLS3_k127_7764760_8 Transposase DDE domain K07492 - - 0.000000000000001666 79.0
TLS3_k127_7764760_9 Nitroreductase - - - 0.00000000000002379 76.0
TLS3_k127_7765097_0 Tetrapyrrole (Corrin/Porphyrin) Methylases K05934 - 2.1.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008636 443.0
TLS3_k127_7765097_1 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 313.0
TLS3_k127_7765097_2 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001198 251.0
TLS3_k127_7771877_0 - - - - 0.00000000000000000003713 97.0
TLS3_k127_7773943_0 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 388.0
TLS3_k127_7773943_1 Belongs to the arginase family K01476 - 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009245 334.0
TLS3_k127_7773943_2 - - - - 0.000000000000000000000000000000000000000000000000000001369 196.0
TLS3_k127_7773943_3 - - - - 0.00000000000000000000000000000000000000000000000002 184.0
TLS3_k127_7773943_5 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000001491 86.0
TLS3_k127_7773943_6 Diacylglycerol kinase catalytic domain - - - 0.000004771 55.0
TLS3_k127_7773943_7 diacylglycerol kinase, catalytic - - - 0.0002416 44.0
TLS3_k127_7774197_0 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004968 550.0
TLS3_k127_7783538_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 - - 9.89e-249 771.0
TLS3_k127_7783538_1 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 452.0
TLS3_k127_7783538_10 - - - - 0.0000005079 55.0
TLS3_k127_7783538_11 PFAM SNARE associated Golgi protein - - - 0.00001516 49.0
TLS3_k127_7783538_2 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 445.0
TLS3_k127_7783538_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005247 321.0
TLS3_k127_7783538_4 phosphohydrolase (DHH superfamily) K07097 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000977 294.0
TLS3_k127_7783538_5 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000143 248.0
TLS3_k127_7783538_6 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000000001577 192.0
TLS3_k127_7783538_7 - - - - 0.00000000000000000000000000000000000000188 151.0
TLS3_k127_7783538_8 Putative tRNA binding domain K06878 - - 0.000000000000000000000000000115 118.0
TLS3_k127_7783538_9 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000003145 115.0
TLS3_k127_7784258_0 Monooxygenase subunit B protein K10945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002119 265.0
TLS3_k127_7784258_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000008314 143.0
TLS3_k127_7786572_0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 404.0
TLS3_k127_7786572_1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.00000000000000000000000000000000000000000000000000000000001371 211.0
TLS3_k127_7786572_2 - - - - 0.000000000000000000001598 94.0
TLS3_k127_7786572_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000000005923 93.0
TLS3_k127_7786572_4 PIN domain of ribonuclease K07060 - - 0.0000000000000007273 83.0
TLS3_k127_7786572_5 - - - - 0.0000000000001811 72.0
TLS3_k127_7786572_6 IMP dehydrogenase activity - - - 0.0000000000004594 71.0
TLS3_k127_7792895_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 2151.0
TLS3_k127_7792895_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K13798 - 2.7.7.6 0.0 2039.0
TLS3_k127_7792895_10 - K03646 - - 0.00000000000000237 78.0
TLS3_k127_7792895_11 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.00000000001071 69.0
TLS3_k127_7792895_12 - - - - 0.0002198 49.0
TLS3_k127_7792895_2 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K18604 - 2.1.3.15,6.4.1.2,6.4.1.3 1.768e-274 850.0
TLS3_k127_7792895_3 Carbamoyl-phosphate synthase L chain K18603 - 6.4.1.2,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 432.0
TLS3_k127_7792895_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 393.0
TLS3_k127_7792895_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006637 314.0
TLS3_k127_7792895_6 ATPase family associated with various cellular activities (AAA) K04800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 312.0
TLS3_k127_7792895_7 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004491 262.0
TLS3_k127_7792895_8 Participates in transcription termination K02600 - - 0.00000000000000000000000000000000000000000000000000000000001839 209.0
TLS3_k127_7792895_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000001734 124.0
TLS3_k127_7798979_0 TIGRFAM 2-methylcitrate synthase citrate synthase II K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 417.0
TLS3_k127_7798979_1 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 370.0
TLS3_k127_7798979_2 Histone acetyltransferase K07739 - 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 370.0
TLS3_k127_7807153_0 UbiD family decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 568.0
TLS3_k127_7807153_1 Domain of unknown function DUF87 K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 534.0
TLS3_k127_7807153_2 AAA domain K03546 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007523 511.0
TLS3_k127_7807153_3 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 362.0
TLS3_k127_7807153_4 - - - - 0.000000000000000004606 86.0
TLS3_k127_7807153_5 - - - - 0.000000000008733 70.0
TLS3_k127_7821398_0 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 606.0
TLS3_k127_7821398_1 alcohol dehydrogenase - - - 0.00002314 47.0
TLS3_k127_7852399_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665,K06883 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008241 395.0
TLS3_k127_7852399_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.0000000000000003546 79.0
TLS3_k127_7852399_2 ChaB K06197 - - 0.000000000000000428 80.0
TLS3_k127_7852399_3 Psort location Cytoplasmic, score 8.87 - - - 0.000000000004064 72.0
TLS3_k127_7852399_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00001962 50.0
TLS3_k127_7852764_0 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 321.0
TLS3_k127_7852764_1 - - - - 0.00002655 53.0
TLS3_k127_7855819_0 Integrase core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008027 320.0
TLS3_k127_7855819_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008847 297.0
TLS3_k127_7855819_2 - - - - 0.000000000000000000000000002383 124.0
TLS3_k127_7855819_3 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily K08698 - - 0.0000000000000000000000009532 105.0
TLS3_k127_7855819_4 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000003128 74.0
TLS3_k127_7855819_5 - - - - 0.00007225 51.0
TLS3_k127_7863374_0 Appr-1'-p processing enzyme - - - 0.0000000000000000000000000000000000000000000000000000001344 199.0
TLS3_k127_7863374_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000002567 188.0
TLS3_k127_7863374_2 Cyclophilin-like K09143 - - 0.00000000000000000000000000001129 122.0
TLS3_k127_7863374_3 Circadian clock protein KaiC - - - 0.0000000000000005639 85.0
TLS3_k127_7863374_4 acetyltransferases and hydrolases with the alpha beta hydrolase fold K01046 - 3.1.1.3 0.000000001933 68.0
TLS3_k127_7863374_5 histidine kinase A domain protein K02482 - 2.7.13.3 0.000000005175 60.0
TLS3_k127_7863374_6 Domain of unknown function (DUF4157) K02689,K02690 - - 0.0000006197 60.0
TLS3_k127_7876547_0 Pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 492.0
TLS3_k127_7876547_1 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 441.0
TLS3_k127_7876547_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 365.0
TLS3_k127_7876547_3 Xylose isomerase-like TIM barrel K22233 - - 0.00000000000000000000002603 110.0
TLS3_k127_7876547_4 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000001689 93.0
TLS3_k127_7876547_6 DDE superfamily endonuclease - - - 0.0000000001985 68.0
TLS3_k127_7876547_7 Winged helix-turn helix - - - 0.000000001184 66.0
TLS3_k127_787748_0 aldo-keto reductase (NADP) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 343.0
TLS3_k127_787748_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007403 325.0
TLS3_k127_787748_2 - - - - 0.000000000000000000000000001232 117.0
TLS3_k127_787748_4 Beta-lactamase - - - 0.000000000955 61.0
TLS3_k127_7939212_0 NUDIX domain - - - 0.0000000000000000000000000000000000001334 146.0
TLS3_k127_7939212_1 - - - - 0.000000000000000000000000004891 118.0
TLS3_k127_7939212_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000001445 87.0
TLS3_k127_7939212_3 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.000000000000000003536 90.0
TLS3_k127_7950580_0 - - - - 0.00000000000000000000000000000000000000000000000000008172 192.0
TLS3_k127_7950580_1 GAF domain - - - 0.000000000000000000002197 109.0
TLS3_k127_7952627_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 391.0
TLS3_k127_7952627_1 Dodecin K09165 - - 0.0000000001827 63.0
TLS3_k127_7953968_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00313 - - 7.259e-252 790.0
TLS3_k127_7953968_1 Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 524.0
TLS3_k127_7953968_2 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 404.0
TLS3_k127_7953968_3 PFAM Ferritin, Dps family protein K02217 - 1.16.3.2 0.00000000000000000000000000000000000000000000000000000007966 199.0
TLS3_k127_7953968_4 - - - - 0.000000000000000000000000000003131 137.0
TLS3_k127_7953968_5 Polysaccharide deacetylase - - - 0.0000000000000008854 89.0
TLS3_k127_7954220_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 300.0
TLS3_k127_7958551_0 Chlorophyllase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000001992 178.0
TLS3_k127_7972169_0 Heat shock 70 kDa protein K04043 - - 4.746e-299 927.0
TLS3_k127_7972169_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 5.859e-201 632.0
TLS3_k127_7972169_2 ThiF family K21029 - 2.7.7.80 6.711e-195 617.0
TLS3_k127_7972169_3 DnaJ central domain K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003899 457.0
TLS3_k127_7972169_4 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 441.0
TLS3_k127_7972169_5 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 371.0
TLS3_k127_7972169_6 Translation initiation factor K03238 - - 0.0000000000000000000000000000000000000000000000000000000000000000002177 232.0
TLS3_k127_7972169_7 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000003594 166.0
TLS3_k127_7972169_8 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000001432 152.0
TLS3_k127_7984710_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.00000000000000000000000000000000000000000000005735 175.0
TLS3_k127_7984710_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.00000000005044 64.0
TLS3_k127_8020260_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 497.0
TLS3_k127_8020260_1 Translation initiation factor 2, alpha subunit K03237 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 329.0
TLS3_k127_8020260_2 ATP corrinoid adenosyltransferase K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000642 232.0
TLS3_k127_8020260_3 SPTR Transposase, IS4 family protein - - - 0.000000000000000000000000000000000000000000000000006593 190.0
TLS3_k127_8020260_4 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000005858 151.0
TLS3_k127_8020260_5 Tetrahydromethanopterin S-methyltransferase, subunit A K00577 - 2.1.1.86 0.0000000000000000000000000000004147 128.0
TLS3_k127_8020260_6 - - - - 0.000000000000000000000007691 103.0
TLS3_k127_8020260_7 - - - - 0.00000000000004609 82.0
TLS3_k127_8020260_8 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000134 72.0
TLS3_k127_806827_0 NAD(P)H-dependent FMN reductase - - - 0.0000000000000000000000000002684 116.0
TLS3_k127_806827_1 NAD(P)H-dependent FMN reductase - - - 0.000000000000000000000006392 104.0
TLS3_k127_806827_2 Transcription factor zinc-finger K09981 - - 0.0000000000000000002436 90.0
TLS3_k127_8092840_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 9.989e-216 677.0
TLS3_k127_8092840_1 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 2.176e-198 638.0
TLS3_k127_8092840_10 SPTR Transposase, IS4 family protein - - - 0.0000000000000001861 84.0
TLS3_k127_8092840_11 Zinc finger, C2H2 type - - - 0.00000000003669 65.0
TLS3_k127_8092840_13 SPTR Transposase, IS4 family protein - - - 0.000000009629 63.0
TLS3_k127_8092840_14 SPTR Transposase, IS4 family protein - - - 0.0000009344 54.0
TLS3_k127_8092840_2 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000003385 201.0
TLS3_k127_8092840_3 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000009656 213.0
TLS3_k127_8092840_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000006131 162.0
TLS3_k127_8092840_5 - - - - 0.00000000000000000000000000000000001205 142.0
TLS3_k127_8092840_6 - - - - 0.0000000000000000000000000000007615 124.0
TLS3_k127_8092840_7 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase - - - 0.000000000000000000000000002763 118.0
TLS3_k127_8092840_8 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000001039 99.0
TLS3_k127_8097320_0 cytochrome P450 K00493,K21201 - 1.11.1.7,1.14.14.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008945 274.0
TLS3_k127_8097320_1 COG3316 Transposase and inactivated derivatives - - - 0.000005543 51.0
TLS3_k127_814123_0 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 319.0
TLS3_k127_814123_1 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 291.0
TLS3_k127_814123_2 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.0000000000000000003707 98.0
TLS3_k127_815891_0 synthetase (class II) K01880 - 6.1.1.14 2.861e-218 686.0
TLS3_k127_815891_1 Glycosyl transferase family 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 426.0
TLS3_k127_815891_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 293.0
TLS3_k127_815891_3 glutamine amidotransferase K01951 - 6.3.5.2 0.000000000000000000000000000000000001566 145.0
TLS3_k127_8227693_0 PFAM 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000006154 190.0
TLS3_k127_8227693_1 PFAM 4Fe-4S dicluster domain - - - 0.000000000000000007262 85.0
TLS3_k127_8275119_0 PFAM Transposase DDE domain - - - 0.000000000001579 78.0
TLS3_k127_8275119_1 Monooxygenase - - - 0.000000628 56.0
TLS3_k127_8293333_0 phosphoesterase, PA-phosphatase related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 448.0
TLS3_k127_8406219_0 Transposase DDE domain K07492 - - 0.0000000000000000000000000000000000006803 145.0
TLS3_k127_8406219_1 This gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.0000000000000000006669 91.0
TLS3_k127_8406219_2 AMP binding - - - 0.000000003954 59.0
TLS3_k127_8448725_0 Required for chromosome condensation and partitioning - - - 0.0000000000004494 82.0
TLS3_k127_8448725_1 PFAM Transposase DDE domain - - - 0.00000001257 60.0
TLS3_k127_8448725_2 PFAM transposase, IS4 family protein - - - 0.00002197 50.0
TLS3_k127_8459829_0 Belongs to the MCM family K10726 - - 0.0 1056.0
TLS3_k127_8459829_1 Replication factor C K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 391.0
TLS3_k127_8459829_10 - - - - 0.0000000000000000000000000000000000000001896 158.0
TLS3_k127_8459829_11 Belongs to the class-I aminoacyl-tRNA synthetase family - - - 0.00000000000000000000000000000000000003154 145.0
TLS3_k127_8459829_12 zinc-ribbon domain - - - 0.000000000000000000000000000000001007 134.0
TLS3_k127_8459829_2 PFAM Permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 386.0
TLS3_k127_8459829_3 Queuosine biosynthesis protein QueC K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000969 263.0
TLS3_k127_8459829_4 ABC 3 transport family K02075,K09816,K09819 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000141 263.0
TLS3_k127_8459829_5 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000003925 259.0
TLS3_k127_8459829_6 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000006245 241.0
TLS3_k127_8459829_7 AAA domain, putative AbiEii toxin, Type IV TA system K02074,K09817,K11607,K11710 - - 0.0000000000000000000000000000000000000000000000000000000000002462 220.0
TLS3_k127_8459829_9 GINS complex protein K09723 - - 0.00000000000000000000000000000000000000000156 162.0
TLS3_k127_8503032_0 Catalyzes the NAD( )-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non- methylotrophic organisms K00122 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 435.0
TLS3_k127_8503032_1 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000002777 221.0
TLS3_k127_8503032_2 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000001137 136.0
TLS3_k127_8503032_3 PFAM Integrase core domain K07497 - - 0.00000000000000000000000000000007583 126.0
TLS3_k127_8503032_4 - - - - 0.0000000000008206 70.0
TLS3_k127_8503032_5 flavodoxin nitric oxide synthase - - - 0.000001867 51.0
TLS3_k127_8503032_6 - - - - 0.00004337 46.0
TLS3_k127_8503032_7 - - - - 0.0008835 45.0
TLS3_k127_8512297_0 integrase family - - - 0.000000004675 66.0
TLS3_k127_8512297_1 Phage integrase family - - - 0.00000005064 59.0
TLS3_k127_8512297_2 Copper binding proteins, plastocyanin/azurin family - - - 0.0004736 42.0
TLS3_k127_8544175_0 phosphonate ABC transporter, inner membrane subunit K02042 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 339.0
TLS3_k127_8544175_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 332.0
TLS3_k127_8544175_2 ABC transporter K02041 - 3.6.3.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002184 272.0
TLS3_k127_8554492_0 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 3.136e-266 833.0
TLS3_k127_8554492_1 oxalate decarboxylase activity K01569 - 4.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000004019 250.0
TLS3_k127_8554492_2 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000005927 231.0
TLS3_k127_8554492_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000005149 151.0
TLS3_k127_8554492_4 Belongs to the arginase family K01476 - 3.5.3.1 0.0000000000000000000000000001517 115.0
TLS3_k127_8554492_5 Belongs to the arginase family K01476 - 3.5.3.1 0.00000000000000000000001043 105.0
TLS3_k127_8579064_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 310.0
TLS3_k127_8579064_1 inner membrane component K02033 - - 0.0000000000000000000000000000000000001542 147.0
TLS3_k127_8579306_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 9.675e-285 892.0
TLS3_k127_8579306_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007281 426.0
TLS3_k127_8579306_2 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 421.0
TLS3_k127_8579306_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 361.0
TLS3_k127_8579306_4 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000000000000000000000000000266 136.0
TLS3_k127_8579306_5 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.0000000000000000000000000000000001931 132.0
TLS3_k127_8579306_6 - - - - 0.0000000000000000000000000000000004389 139.0
TLS3_k127_8579306_7 PFAM regulatory protein, ArsR - - - 0.0000000000000000000000000002461 117.0
TLS3_k127_8579306_8 - - - - 0.00000000000000000000003739 100.0
TLS3_k127_859762_0 - - - - 0.0 1012.0
TLS3_k127_862046_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 364.0
TLS3_k127_862046_1 COG2406 Protein distantly related to bacterial ferritins K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000002067 227.0
TLS3_k127_862046_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000003474 73.0
TLS3_k127_862046_5 - - - - 0.00000001691 59.0
TLS3_k127_862046_6 Bacterial regulatory protein, arsR family - - - 0.00000005854 55.0
TLS3_k127_862046_7 PFAM Acetyltransferase (GNAT) family - - - 0.0008381 44.0
TLS3_k127_863985_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 370.0
TLS3_k127_863985_1 UV-endonuclease UvdE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004476 319.0
TLS3_k127_863985_2 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000001539 189.0
TLS3_k127_863985_3 epimerase K07071 - - 0.0000000000000000000000000000000000000000001543 166.0
TLS3_k127_863985_4 - - - - 0.0000000000000000000006469 102.0
TLS3_k127_863985_5 Phage integrase family - - - 0.0000000000000001445 89.0
TLS3_k127_863985_6 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0000000000001574 75.0
TLS3_k127_863985_7 DDE superfamily endonuclease - - - 0.00000005426 58.0
TLS3_k127_863985_8 - - - - 0.0001018 47.0
TLS3_k127_863985_9 - - - - 0.0004156 47.0
TLS3_k127_881403_0 Transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009005 362.0
TLS3_k127_887998_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000002055 170.0
TLS3_k127_887998_1 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000000007371 163.0
TLS3_k127_887998_2 PFAM flavin reductase domain protein, FMN-binding K03574,K18915 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016722,GO:0016723,GO:0032553,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.16.1.10,3.6.1.55 0.000000000000000000000000008169 117.0
TLS3_k127_887998_3 - - - - 0.000000000000000000002797 105.0
TLS3_k127_887998_4 B12 binding domain - - - 0.00000000000000004626 91.0
TLS3_k127_887998_5 - - - - 0.000000000004053 68.0
TLS3_k127_887998_6 PFAM Antibiotic biosynthesis monooxygenase - - - 0.000000313 56.0
TLS3_k127_887998_7 - - - - 0.000488 48.0
TLS3_k127_888394_1 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000002124 215.0
TLS3_k127_888394_10 Transposase DDE domain - - - 0.0000004251 61.0
TLS3_k127_888394_11 PFAM 4Fe-4S dicluster domain - - - 0.000006361 48.0
TLS3_k127_888394_2 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000003333 181.0
TLS3_k127_888394_3 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000008699 125.0
TLS3_k127_888394_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000001561 112.0
TLS3_k127_888394_5 Methyltransferase type 11 K07755 - 2.1.1.137 0.0000000000000000000000004479 107.0
TLS3_k127_888394_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000003154 98.0
TLS3_k127_888394_7 Hypothetical methyltransferase K07755 - 2.1.1.137 0.0000000000000000001766 91.0
TLS3_k127_888394_8 PFAM TM2 domain containing protein K03686 - - 0.000000000000003806 80.0
TLS3_k127_888394_9 Mechanosensitive ion channel - - - 0.000000000007887 73.0
TLS3_k127_891223_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005558 267.0
TLS3_k127_891223_1 - - - - 0.000000000000000000000000000000000000000000000000000000000001273 215.0
TLS3_k127_891223_2 - - - - 0.00000000000000000000000000000000000000003005 158.0
TLS3_k127_891223_3 - - - - 0.00000000000000000000000000000000000000005672 152.0
TLS3_k127_891223_6 - - - - 0.00000000000000001933 83.0
TLS3_k127_891223_8 - - - - 0.00000000001805 73.0
TLS3_k127_891223_9 Periplasmic copper-binding protein (NosD) - - - 0.00000001117 66.0
TLS3_k127_896352_0 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.000958 45.0
TLS3_k127_90933_0 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 298.0
TLS3_k127_90933_1 COG1335 Amidases related to nicotinamidase K09020 - 3.5.1.110 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004222 276.0
TLS3_k127_90933_2 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000000000000001695 215.0
TLS3_k127_90933_4 Sodium hydrogen exchanger - - - 0.00000000000000000002453 91.0
TLS3_k127_90933_5 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000001136 88.0
TLS3_k127_90933_6 GAF domain - - - 0.0000005972 53.0
TLS3_k127_91151_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 2.437e-211 667.0
TLS3_k127_91151_1 TIGRFAM excinuclease ABC, C subunit K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 521.0
TLS3_k127_91151_2 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007772 404.0
TLS3_k127_919404_0 ligase activity - - - 0.0000000000000000000000000000000001597 146.0
TLS3_k127_919404_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000001505 100.0
TLS3_k127_92454_0 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000005007 171.0
TLS3_k127_92454_1 biotin carboxyl carrier K00627,K01571,K15037,K18605 - 2.3.1.12,4.1.1.3 0.00000000000000000000000000000000000000000003786 166.0
TLS3_k127_92454_2 Cysteine desulfurase K04487 - 2.8.1.7 0.00000000000000000000001366 102.0
TLS3_k127_93564_0 - - - - 0.000000000000000000000000000000000000000000000000000002061 198.0
TLS3_k127_93564_1 resistance protein K14166 - - 0.00000000000000000000000000000000000000000000000000008287 205.0
TLS3_k127_944570_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005413 410.0
TLS3_k127_944570_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000001076 267.0
TLS3_k127_944570_2 GHMP kinases N terminal domain K00891 - 2.7.1.71 0.00000003307 55.0
TLS3_k127_945763_0 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000002014 162.0
TLS3_k127_945763_1 MgtC family K07507 - - 0.00000000006944 66.0
TLS3_k127_95091_0 Chromate resistance - - - 0.00000000000000000000000000000000000000000000000000000000000000291 220.0
TLS3_k127_95091_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000008067 221.0
TLS3_k127_95091_2 - - - - 0.0000000000000000000000000000001188 128.0
TLS3_k127_95091_3 DJ-1/PfpI family - - - 0.000000003542 58.0
TLS3_k127_95091_4 PFAM Protein kinase domain - - - 0.00001582 54.0
TLS3_k127_952050_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000000000000000003082 139.0
TLS3_k127_952050_2 - - - - 0.00000000000000000001009 98.0
TLS3_k127_952050_3 Protein of unknown function (DUF1326) - - - 0.0000000000000000008298 87.0
TLS3_k127_952050_4 SPTR Transposase, IS4 family protein - - - 0.00002069 51.0
TLS3_k127_954043_0 Anticodon-binding domain of tRNA K01873 - 6.1.1.9 0.0 1071.0
TLS3_k127_954043_1 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 327.0
TLS3_k127_954043_2 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 325.0
TLS3_k127_954043_3 F5/8 type C domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003824 278.0
TLS3_k127_954043_4 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000001633 239.0
TLS3_k127_954043_5 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000007845 226.0
TLS3_k127_954043_6 - - - - 0.000000000000000000000000000000000000000001513 158.0
TLS3_k127_956050_0 cation diffusion facilitator family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005042 336.0
TLS3_k127_956050_1 Universal stress protein family - - - 0.0000000002893 66.0
TLS3_k127_956471_0 SPTR Transposase, IS4 family protein - - - 0.0000000000003154 74.0
TLS3_k127_956471_2 - - - - 0.000000000313 69.0
TLS3_k127_956471_3 Winged helix-turn helix K07494 - - 0.00000006802 61.0
TLS3_k127_956471_4 PFAM Transposase DDE domain - - - 0.00001903 49.0
TLS3_k127_959023_0 PFAM Iron-containing alcohol dehydrogenase K18602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 556.0
TLS3_k127_959023_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 539.0
TLS3_k127_959023_10 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.000000000000000000008002 93.0
TLS3_k127_959023_11 Ribosomal protein S30 K02983 - - 0.00000000000000000131 86.0
TLS3_k127_959023_14 - - - - 0.000002971 55.0
TLS3_k127_959023_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 477.0
TLS3_k127_959023_3 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 304.0
TLS3_k127_959023_4 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 290.0
TLS3_k127_959023_5 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000154 289.0
TLS3_k127_959023_6 Ribosomal protein L15E K02877 - - 0.00000000000000000000000000000000000000000000000000000000000005219 216.0
TLS3_k127_959023_7 - - - - 0.0000000000000000000000000000004202 124.0
TLS3_k127_959023_8 - - - - 0.0000000000000000000000000005109 117.0
TLS3_k127_959023_9 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000004045 115.0
TLS3_k127_983431_0 Phage integrase family - - - 0.00000000000000000002272 101.0
TLS3_k127_998022_0 ribosomal protein K02866 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001115 263.0
TLS3_k127_998022_1 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000000000009432 194.0
TLS3_k127_998022_2 PFAM Methionine sulfoxide reductase B K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000001105 170.0
TLS3_k127_998022_3 COG4618 ABC-type protease lipase transport system, ATPase and permease components - - - 0.000000000000000000000001354 108.0
TLS3_k127_998022_4 - - - - 0.0000000000000001524 85.0
TLS3_k127_998022_6 DDE superfamily endonuclease - - - 0.0001542 50.0