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Overview

ID MAG04117
Name WH2_bin.25
Sample SMP0107
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanosarcinia
Order Methanotrichales
Family Methanotrichaceae
Genus Methanothrix
Species Methanothrix soehngenii
Assembly information
Completeness (%) 87.24
Contamination (%) 1.34
GC content (%) 53.0
N50 (bp) 8,226
Genome size (bp) 2,090,969

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2013

Gene name Description KEGG GOs EC E-value Score Sequence
WH2_k127_10019283_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 2.861e-208 672.0
WH2_k127_10019283_1 Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000552 187.0
WH2_k127_10019283_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000002697 177.0
WH2_k127_10019283_3 Belongs to the UPF0200 family - - - 0.0000000000000000000000000000000000000009381 155.0
WH2_k127_10019283_4 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000000000000000000009105 138.0
WH2_k127_10019283_5 cytidyltransferase-related domain K00952 - 2.7.7.1 0.00000000000000000000000000000003224 129.0
WH2_k127_10019283_6 PFAM DNA polymerase, beta domain protein region K07075 - - 0.000000000009346 68.0
WH2_k127_10019283_7 Transglutaminase-like superfamily - - - 0.00000000007628 74.0
WH2_k127_10107242_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000005289 233.0
WH2_k127_10109872_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 5.304e-261 819.0
WH2_k127_10109872_1 Probable transposase K07496 - - 0.00000000000000000000000000000000002699 136.0
WH2_k127_10124357_0 Aminotransferase class-III K00836 GO:0003674,GO:0003824,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019491,GO:0019752,GO:0032787,GO:0042399,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004655 579.0
WH2_k127_10124357_1 LOR SDH bifunctional enzyme conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 497.0
WH2_k127_10124357_2 Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant K06720 - 4.2.1.108 0.000000000000000000000000000000000000000000000000000001148 195.0
WH2_k127_10124357_3 L-2,4-diaminobutyric acid acetyltransferase K06718 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016407,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019491,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0042399,GO:0043170,GO:0043412,GO:0043436,GO:0043543,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.178 0.000000000000000000000000000000000000000000004552 169.0
WH2_k127_10124357_4 racemase activity, acting on amino acids and derivatives - - - 0.0000000000000000002048 88.0
WH2_k127_10165561_0 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.00000000000000000000000000000000000000000000005515 181.0
WH2_k127_10165561_1 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.0000000002409 65.0
WH2_k127_10165561_2 - - - - 0.00000001108 57.0
WH2_k127_10207127_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1050.0
WH2_k127_10207127_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 6.393e-220 687.0
WH2_k127_10207127_10 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000003212 224.0
WH2_k127_10207127_11 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000008612 234.0
WH2_k127_10207127_12 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000001403 210.0
WH2_k127_10207127_13 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.000000000000000000000000000000000000000000000000001353 191.0
WH2_k127_10207127_14 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000006899 182.0
WH2_k127_10207127_15 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000004719 181.0
WH2_k127_10207127_16 - - - - 0.000000000000000000000000000000000000395 147.0
WH2_k127_10207127_17 Belongs to the GbsR family K22109 - - 0.0000000000009782 75.0
WH2_k127_10207127_18 Ion channel - - - 0.00000006816 64.0
WH2_k127_10207127_19 Binds to the 23S rRNA K02929 - - 0.000001412 49.0
WH2_k127_10207127_2 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 607.0
WH2_k127_10207127_20 protein conserved in archaea K09723 - - 0.00002938 53.0
WH2_k127_10207127_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 458.0
WH2_k127_10207127_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005612 436.0
WH2_k127_10207127_5 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 379.0
WH2_k127_10207127_6 COG3436 Transposase and inactivated derivatives K07484 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 366.0
WH2_k127_10207127_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 312.0
WH2_k127_10207127_8 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 288.0
WH2_k127_10207127_9 PFAM Ion transport protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002313 271.0
WH2_k127_10246058_0 Pfam Sulfatase K01130 - 3.1.6.1 2.424e-227 732.0
WH2_k127_10246058_1 Iron-sulfur cluster-binding domain K06871 - - 4.849e-196 619.0
WH2_k127_10246058_10 UbiA prenyltransferase family K17105 - 2.5.1.42 0.00000000000000000000001008 102.0
WH2_k127_10246058_11 4Fe-4S binding domain - - - 0.000000000005084 68.0
WH2_k127_10246058_12 4Fe-4S binding domain - - - 0.0000000846 56.0
WH2_k127_10246058_13 Protein of unknown function (DUF1016) - - - 0.00000817 51.0
WH2_k127_10246058_14 4Fe-4S binding domain - - - 0.00001506 49.0
WH2_k127_10246058_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006258 406.0
WH2_k127_10246058_3 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003927 273.0
WH2_k127_10246058_4 Functions in trans to edit the amino acid moiety from K07050 GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000001339 225.0
WH2_k127_10246058_5 PFAM extracellular solute-binding protein family 3 K02030 - - 0.0000000000000000000000000000000000000000000000000000000000007166 229.0
WH2_k127_10246058_6 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000002194 188.0
WH2_k127_10246058_7 Glyoxalase bleomycin resistance protein dioxygenase K07032 - - 0.00000000000000000000000000000000000000000003374 165.0
WH2_k127_10246058_8 Acyl-CoA thioester hydrolase/BAAT N-terminal region K06889 - - 0.000000000000000000000000000000000000001398 165.0
WH2_k127_10246058_9 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000000000002445 119.0
WH2_k127_1026316_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 480.0
WH2_k127_1026316_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 469.0
WH2_k127_1026316_10 Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000002452 166.0
WH2_k127_1026316_11 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000004421 131.0
WH2_k127_1026316_12 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.00000000000000000000000000002247 127.0
WH2_k127_1026316_13 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000001426 121.0
WH2_k127_1026316_14 Belongs to the acylphosphatase family - - - 0.00000000000000003939 90.0
WH2_k127_1026316_15 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.00000000108 63.0
WH2_k127_1026316_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 444.0
WH2_k127_1026316_3 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 441.0
WH2_k127_1026316_4 Protein of unknown function (DUF1646) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 349.0
WH2_k127_1026316_5 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008673 309.0
WH2_k127_1026316_6 MacB-like periplasmic core domain K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008753 278.0
WH2_k127_1026316_7 Serine protease with a broad substrate specificity K17734 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000001659 233.0
WH2_k127_1026316_8 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.00000000000000000000000000000000000000000000000005384 186.0
WH2_k127_1026316_9 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000001221 183.0
WH2_k127_10306080_0 Hydantoinase/oxoprolinase N-terminal region - - - 2.067e-195 624.0
WH2_k127_10306080_1 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 350.0
WH2_k127_10306080_2 PFAM Major Facilitator Superfamily - - - 0.00002511 55.0
WH2_k127_10362927_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005461 519.0
WH2_k127_10362927_1 Has ATPase and non-specific DNA-binding activities K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 287.0
WH2_k127_10362927_2 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000000000000000000544 162.0
WH2_k127_10374959_0 Diphthamide synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006595 299.0
WH2_k127_10374959_1 tigrfam pas - - - 0.000000000000000000000000000003695 127.0
WH2_k127_10454403_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1677.0
WH2_k127_10454403_1 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.0 1369.0
WH2_k127_10456709_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 497.0
WH2_k127_10456709_1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K02588,K21610 - 1.18.6.1,6.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 357.0
WH2_k127_10456709_2 Pfam:UPF0118 - - - 0.000000000000000000000000001525 125.0
WH2_k127_10456709_3 Papain family cysteine protease - - - 0.0000000000000000000002294 111.0
WH2_k127_10528801_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 462.0
WH2_k127_10528801_1 Protein of unknown function (DUF2891) - - - 0.00000000000000000000000000000000000000001063 161.0
WH2_k127_10528801_2 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000002146 123.0
WH2_k127_10528801_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000308 53.0
WH2_k127_10533944_0 Transposase, is605 orfb family K07496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008597 265.0
WH2_k127_10533944_1 Met-10+ like-protein K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000004668 178.0
WH2_k127_1054179_0 Threonine synthase N terminus K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 550.0
WH2_k127_1054179_1 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000567 327.0
WH2_k127_1054179_2 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009833 301.0
WH2_k127_1054179_3 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.000000000000000000000000000000000000000000000000000000000000000000003367 241.0
WH2_k127_1054179_4 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000005189 185.0
WH2_k127_1054179_5 PFAM UspA domain protein - - - 0.0000000000000000000000000000000007045 135.0
WH2_k127_10571421_0 Papain family cysteine protease - - - 0.00000000000000000000000000000000000000000000000000000000005328 211.0
WH2_k127_10571421_1 peptidyl-tyrosine sulfation - - - 0.00000000007182 75.0
WH2_k127_10582042_0 ATPases associated with a variety of cellular activities K00400 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 616.0
WH2_k127_10582042_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005921 512.0
WH2_k127_10582042_2 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 342.0
WH2_k127_10582042_3 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000004421 139.0
WH2_k127_10611657_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1090.0
WH2_k127_10611657_1 in RNase L inhibitor, RLI K06174 - - 5.401e-241 757.0
WH2_k127_10611657_10 RIO1 family K08851 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000001166 218.0
WH2_k127_10611657_11 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000009394 210.0
WH2_k127_10611657_12 phosphoribosylglycinamide formyltransferase K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000001565 192.0
WH2_k127_10611657_13 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000004907 160.0
WH2_k127_10611657_14 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000000001655 162.0
WH2_k127_10611657_15 - - - - 0.0000000000000000000000000000000000000003475 162.0
WH2_k127_10611657_16 signal transduction protein with CBS domains - - - 0.00000000000000000000000000000000000008247 149.0
WH2_k127_10611657_17 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000000000003771 124.0
WH2_k127_10611657_18 PIN domain of ribonuclease K07060 - - 0.0000000000000000000000000003709 124.0
WH2_k127_10611657_19 InterPro IPR007367 - - - 0.000000000000000000000000005351 113.0
WH2_k127_10611657_2 LOR SDH bifunctional enzyme conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 504.0
WH2_k127_10611657_20 RNase L inhibitor, RLI - - - 0.000000000000000003273 92.0
WH2_k127_10611657_21 - - - - 0.00000000000000001933 83.0
WH2_k127_10611657_22 - - - - 0.00000000009336 72.0
WH2_k127_10611657_3 RNA ligase K07468 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 350.0
WH2_k127_10611657_4 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008109 295.0
WH2_k127_10611657_5 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 292.0
WH2_k127_10611657_6 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006715 259.0
WH2_k127_10611657_7 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001127 257.0
WH2_k127_10611657_8 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000481 232.0
WH2_k127_10611657_9 Hit family K19710 - 2.7.7.53 0.000000000000000000000000000000000000000000000000000000000000002338 222.0
WH2_k127_10614730_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 426.0
WH2_k127_10614730_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001909 267.0
WH2_k127_10614730_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000000002379 200.0
WH2_k127_10614730_3 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000004468 152.0
WH2_k127_10633015_0 stress-induced mitochondrial fusion - - - 0.000000000000000000000000000000000003201 148.0
WH2_k127_10711458_0 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006905 274.0
WH2_k127_10711458_1 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000001023 109.0
WH2_k127_10711458_2 Rubredoxin - - - 0.000000000009878 69.0
WH2_k127_10725376_0 PFAM Cytidine and deoxycytidylate deaminase zinc-binding region K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000003062 188.0
WH2_k127_10725376_1 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000002319 138.0
WH2_k127_10757267_0 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 358.0
WH2_k127_10757267_1 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000003392 230.0
WH2_k127_10757267_2 PFAM regulatory protein, ArsR - - - 0.00000000000000000005268 93.0
WH2_k127_10757267_3 - - - - 0.0000000008333 64.0
WH2_k127_10757267_4 methyltransferase K01921 - 6.3.2.4 0.0000002875 54.0
WH2_k127_10810401_0 DNA RNA helicase, superfamily II, SNF2 family K08282 - 2.7.11.1 4.153e-255 805.0
WH2_k127_10810401_1 SWIM zinc finger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 288.0
WH2_k127_10810401_2 PIN domain - - - 0.00000000000000000000000003893 111.0
WH2_k127_10810401_3 Uncharacterized protein conserved in bacteria (DUF2188) - - - 0.0000001104 57.0
WH2_k127_1152219_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 1.105e-295 919.0
WH2_k127_1152219_1 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 3.142e-275 858.0
WH2_k127_1152219_10 Domain of unknown function (DUF1894) - - - 0.00000000000000000000000000000000002225 139.0
WH2_k127_1152219_11 Molybdopterin converting factor K03635 - 2.8.1.12 0.0000000000000000000000000000000004624 134.0
WH2_k127_1152219_12 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000003347 112.0
WH2_k127_1152219_13 - - - - 0.0000000000000000000002307 100.0
WH2_k127_1152219_14 Molybdopterin converting factor, small subunit K03636 - - 0.00000000000004039 76.0
WH2_k127_1152219_15 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.00000698 50.0
WH2_k127_1152219_2 4Fe-4S double cluster binding domain K00205 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 453.0
WH2_k127_1152219_3 GXGXG motif K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 312.0
WH2_k127_1152219_4 Molybdopterin oxidoreductase K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 292.0
WH2_k127_1152219_5 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002976 281.0
WH2_k127_1152219_6 Hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009736 265.0
WH2_k127_1152219_7 Domain of unknown function (DUF1890) - - - 0.0000000000000000000000000000000000000000000000000009464 187.0
WH2_k127_1152219_8 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000005135 188.0
WH2_k127_1152219_9 Molydopterin dinucleotide binding domain K00203 - 1.2.7.12 0.00000000000000000000000000000000000000000006277 168.0
WH2_k127_1166888_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 615.0
WH2_k127_1166888_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000596 293.0
WH2_k127_1241699_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K22446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007338 270.0
WH2_k127_1241699_1 Transposase, is605 orfb family K07496 - - 0.000000000000000000000000000000716 135.0
WH2_k127_1241699_2 TRAM domain - - - 0.00000000000000001867 84.0
WH2_k127_1241699_3 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.000000000000001047 80.0
WH2_k127_1364409_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009595 409.0
WH2_k127_1364409_1 transcription activator, effector binding - - - 0.00000000000000000000000000000000000000000001429 166.0
WH2_k127_1364409_2 COG1943 Transposase and inactivated derivatives K07491 - - 0.00000000000000000000000001032 110.0
WH2_k127_1364409_3 Transposase - - - 0.0004566 43.0
WH2_k127_138220_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 1.315e-220 700.0
WH2_k127_138220_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 304.0
WH2_k127_138220_2 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007311 297.0
WH2_k127_138220_3 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 295.0
WH2_k127_138220_4 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000182 234.0
WH2_k127_138220_5 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.00000000000000000000000000000000000005743 144.0
WH2_k127_138220_6 Molybdopterin biosynthesis protein MoeA LysR substrate binding-domain-containing protein K03750,K07219 - 2.10.1.1 0.00000000000000000000001385 109.0
WH2_k127_138220_7 COG3634 Alkyl hydroperoxide reductase, large subunit - - - 0.0000000000000000000193 96.0
WH2_k127_138220_8 Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation - - - 0.000000000000005861 76.0
WH2_k127_1435855_0 Lamin Tail Domain K07004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 454.0
WH2_k127_1435855_1 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 376.0
WH2_k127_1435855_2 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000136 250.0
WH2_k127_1435855_3 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000006848 167.0
WH2_k127_1435855_4 nucleotidyltransferase activity K07076 - - 0.000000000000004776 86.0
WH2_k127_1435855_5 Belongs to the N(4) N(6)-methyltransferase family K07316 - 2.1.1.72 0.00002609 49.0
WH2_k127_1437924_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 396.0
WH2_k127_1437924_1 Methyltransferase K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008932 331.0
WH2_k127_1437924_2 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 321.0
WH2_k127_1437924_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002221 246.0
WH2_k127_1437924_4 serine-type aminopeptidase activity K02030,K14475 - - 0.000000000000000000000001796 104.0
WH2_k127_1437924_5 Iron-sulphur cluster biosynthesis K15724 - - 0.000000000005243 72.0
WH2_k127_1464180_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 375.0
WH2_k127_1464180_1 PFAM Iron-binding zinc finger CDGSH type - - - 0.000000000000000000000000000000000000007634 149.0
WH2_k127_1464180_2 Tetratricopeptide repeat - - - 0.00000000000000000000000007545 124.0
WH2_k127_1464180_3 - - - - 0.00000000158 66.0
WH2_k127_1464180_4 - - - - 0.0000001271 55.0
WH2_k127_1464180_5 Protein of unknown function (DUF1328) - - - 0.000007924 51.0
WH2_k127_1488822_0 PFAM Endonuclease Exonuclease phosphatase K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 357.0
WH2_k127_1488822_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000001848 139.0
WH2_k127_1488822_2 Belongs to the acylphosphatase family - - - 0.00000000000000001264 88.0
WH2_k127_1496562_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 531.0
WH2_k127_1496562_1 Transposase, is605 orfb family K07496 - - 0.0000000000000000000000000000000000000000000000000000000000000000008538 240.0
WH2_k127_1518162_0 PFAM Radical SAM domain protein K02585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000866 350.0
WH2_k127_1518162_1 Uncharacterized ArCR, COG1888 K09732 - - 0.00000000000000000000000001513 111.0
WH2_k127_1518162_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.000000000000001192 80.0
WH2_k127_1578519_0 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 299.0
WH2_k127_1578519_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 291.0
WH2_k127_1578519_10 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.00000000000000000007601 89.0
WH2_k127_1578519_11 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.0001071 44.0
WH2_k127_1578519_2 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000002567 217.0
WH2_k127_1578519_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000006621 209.0
WH2_k127_1578519_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000002657 198.0
WH2_k127_1578519_5 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000000003819 195.0
WH2_k127_1578519_6 TIGRFAM ribosomal protein L30P K02907 - - 0.00000000000000000000000000000000000000000000000000232 186.0
WH2_k127_1578519_7 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000000000000002302 163.0
WH2_k127_1578519_8 PFAM Ribosomal protein K02912 - - 0.000000000000000000000000000002352 123.0
WH2_k127_1578519_9 binds to the 23S rRNA K02876 - - 0.0000000000000000000002375 103.0
WH2_k127_1633554_0 Polyprenyl synthetase K02523 GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765 2.5.1.90 0.0000000000000000000000000000000000000000000000000008355 192.0
WH2_k127_1633554_1 CoA-binding domain protein K06929 - - 0.0000000000000000000000000000000000000000000000000472 183.0
WH2_k127_1660517_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 4.927e-242 759.0
WH2_k127_1660517_1 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 507.0
WH2_k127_1660517_2 Probable transposase K07496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 485.0
WH2_k127_1660517_3 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008056 307.0
WH2_k127_1660517_4 - - - - 0.00000000000000000000274 94.0
WH2_k127_1660517_5 Nitroreductase - - - 0.000005153 56.0
WH2_k127_168608_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 1.207e-209 666.0
WH2_k127_168608_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003088 289.0
WH2_k127_168608_2 indolepyruvate ferredoxin oxidoreductase, beta subunit K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000001436 184.0
WH2_k127_1691760_0 TIGRFAM formate dehydrogenase, alpha subunit K00336,K05299 - 1.17.1.10,1.6.5.3 2.511e-291 921.0
WH2_k127_1691760_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 499.0
WH2_k127_1691760_2 TIR domain - - - 0.00000000000000000000000000000000000000000000000000000001193 203.0
WH2_k127_1691760_3 Pyridine nucleotide-disulphide oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000003101 146.0
WH2_k127_1691760_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000003837 109.0
WH2_k127_1691760_5 Dodecin K09165 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000001782 83.0
WH2_k127_1691760_6 Protein of unknown function DUF104 - - - 0.00001321 49.0
WH2_k127_1757641_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 399.0
WH2_k127_1757641_1 nuclease activity - - - 0.000000000000000000000000000000000000000000000000002336 185.0
WH2_k127_1757641_2 Reverse transcriptase-like K03469 - 3.1.26.4 0.000000000000000000000000001354 118.0
WH2_k127_1757641_3 DNA polymerase beta domain protein region - - - 0.00000000000004248 79.0
WH2_k127_1757641_5 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000002298 64.0
WH2_k127_1757641_6 Protein of unknown function (DUF1016) - - - 0.00000008147 61.0
WH2_k127_1761096_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 7.282e-242 759.0
WH2_k127_1761096_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 5.561e-229 715.0
WH2_k127_1761096_10 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 300.0
WH2_k127_1761096_11 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 299.0
WH2_k127_1761096_12 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001006 254.0
WH2_k127_1761096_13 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000002276 241.0
WH2_k127_1761096_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000003874 224.0
WH2_k127_1761096_15 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000001444 200.0
WH2_k127_1761096_16 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000158 187.0
WH2_k127_1761096_17 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000005533 188.0
WH2_k127_1761096_18 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000000000000000004415 182.0
WH2_k127_1761096_19 Bacterio-opsin activator HTH K06930,K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000001361 167.0
WH2_k127_1761096_2 Fructose-bisphosphate aldolase class-II - - - 9.097e-216 678.0
WH2_k127_1761096_20 PFAM Cobalt transport protein K02008 - - 0.000000000000000000000000000000001513 140.0
WH2_k127_1761096_21 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000000000001051 115.0
WH2_k127_1761096_22 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000003453 114.0
WH2_k127_1761096_23 Helix-turn-helix XRE-family like proteins K07729 - - 0.00000000000000000000000004665 109.0
WH2_k127_1761096_24 - - - - 0.000000000000000000000002156 107.0
WH2_k127_1761096_25 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.00000000000000000004554 92.0
WH2_k127_1761096_26 ATP synthase subunit C K02124 - - 0.0000000000000000003664 89.0
WH2_k127_1761096_27 ABC-type transport system involved in lipoprotein release permease component K09808 - - 0.0000000000001594 82.0
WH2_k127_1761096_28 - - - - 0.000000000000693 77.0
WH2_k127_1761096_3 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 5.634e-195 617.0
WH2_k127_1761096_30 H subunit K02107 - - 0.00000000002762 68.0
WH2_k127_1761096_31 - - - - 0.0000000002226 66.0
WH2_k127_1761096_32 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000001915 61.0
WH2_k127_1761096_33 - K16915 - - 0.00000004438 62.0
WH2_k127_1761096_34 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 0.00000006349 57.0
WH2_k127_1761096_35 PFAM Nickel transport complex, NikM subunit, transmembrane K16915 - - 0.000002799 53.0
WH2_k127_1761096_36 PFAM Nickel transport complex, NikM subunit, transmembrane K02009 - - 0.00001523 56.0
WH2_k127_1761096_37 Domain of unknown function (DUF4198) - - - 0.0004034 51.0
WH2_k127_1761096_4 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 583.0
WH2_k127_1761096_5 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009961 454.0
WH2_k127_1761096_6 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 383.0
WH2_k127_1761096_7 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 381.0
WH2_k127_1761096_8 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 309.0
WH2_k127_1761096_9 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 298.0
WH2_k127_1772808_0 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 308.0
WH2_k127_1772808_1 PFAM ABC transporter related - - - 0.000000000000000000000000000000000000000000000000000000000000000000009707 242.0
WH2_k127_1777756_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 3.513e-257 801.0
WH2_k127_1777756_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 554.0
WH2_k127_1777756_2 PFAM Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 299.0
WH2_k127_1777756_3 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000003427 203.0
WH2_k127_1777756_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000001787 103.0
WH2_k127_1825527_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 2.576e-241 758.0
WH2_k127_1825527_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 5.981e-199 631.0
WH2_k127_1825527_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 457.0
WH2_k127_1825527_3 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000005673 208.0
WH2_k127_1825527_4 Domain of unknown function DUF1828 - - - 0.00000000000000000000000000000000000000000000000000000001658 200.0
WH2_k127_1839566_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 486.0
WH2_k127_1839566_1 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 361.0
WH2_k127_1839566_2 Response receiver sensor diguanylate cyclase, PAS domain-containing - - - 0.0000000000000000000000009008 118.0
WH2_k127_1898064_0 Protein of unknown function (DUF1616) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001032 290.0
WH2_k127_1898064_1 - - - - 0.00000000000000000003219 101.0
WH2_k127_1954609_0 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.000000000000000000000000000000000000000000000000007281 186.0
WH2_k127_1954609_1 S-layer protein - - - 0.000000000000000000000000001733 128.0
WH2_k127_1954609_2 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000002922 103.0
WH2_k127_1954609_3 DJ-1/PfpI family - - - 0.0000000000000000002972 89.0
WH2_k127_1954609_4 protein deglycase activity - - - 0.00001147 49.0
WH2_k127_1973147_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 2.639e-213 681.0
WH2_k127_1973147_1 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004443 567.0
WH2_k127_1973147_2 Sodium/hydrogen exchanger family K11105 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 484.0
WH2_k127_1973147_3 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000002098 242.0
WH2_k127_1973147_4 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000001336 226.0
WH2_k127_1973147_5 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000001674 170.0
WH2_k127_1973147_6 PFAM Cupin - - - 0.00000000000000000000000000000000000000003909 155.0
WH2_k127_1973147_7 PFAM RDD domain containing protein - - - 0.0000000000000000000000000000005715 126.0
WH2_k127_2009610_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007084 586.0
WH2_k127_2009610_1 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 335.0
WH2_k127_2009610_10 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000004103 81.0
WH2_k127_2009610_11 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000002872 78.0
WH2_k127_2009610_12 transposase IS891 IS1136 IS1341 family K07496 - - 0.0000001587 55.0
WH2_k127_2009610_13 Chagasin family peptidase inhibitor I42 K14475 - - 0.0000002954 62.0
WH2_k127_2009610_2 Clp protease K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001528 287.0
WH2_k127_2009610_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002091 287.0
WH2_k127_2009610_4 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000001057 244.0
WH2_k127_2009610_5 Probable transposase K07496 - - 0.00000000000000000000000000000000000000000000000000000000000004194 217.0
WH2_k127_2009610_6 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000001139 150.0
WH2_k127_2009610_7 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000001449 106.0
WH2_k127_2009610_8 Large family of predicted nucleotide-binding domains K07158 - - 0.000000000000000000000007303 105.0
WH2_k127_2009610_9 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000009195 90.0
WH2_k127_2038668_0 Cellulose biosynthesis protein BcsQ K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001938 258.0
WH2_k127_2038668_1 Domain of unknown function (DUF4198) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001289 240.0
WH2_k127_2045466_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004871 592.0
WH2_k127_2045466_1 DEAD DEAH box helicase domain protein K03725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 388.0
WH2_k127_2045466_2 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.00000002053 63.0
WH2_k127_2051086_0 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001834 274.0
WH2_k127_2051086_1 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000000000000000003612 208.0
WH2_k127_2051086_2 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.00000000000000000000000000002696 120.0
WH2_k127_2051086_3 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000007686 94.0
WH2_k127_2051086_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.0000000000000000006731 90.0
WH2_k127_2051086_5 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000002114 77.0
WH2_k127_2051086_6 Binds the lower part of the 30S subunit head K02982 - - 0.0002006 48.0
WH2_k127_2058126_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 320.0
WH2_k127_2058126_1 TIGRFAM Na Pi-cotransporter II-related protein K03324 - - 0.00000000000000000000000000000000000000546 150.0
WH2_k127_2058126_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000006184 150.0
WH2_k127_2068177_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 496.0
WH2_k127_2068177_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 400.0
WH2_k127_2068177_2 Periplasmic sensor domain - - - 0.000000000000000000000002824 117.0
WH2_k127_2068177_3 spore germination K08978 - - 0.00000001285 66.0
WH2_k127_2068177_4 Transposase - - - 0.00000005923 55.0
WH2_k127_2069894_0 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 3.461e-224 706.0
WH2_k127_2069894_1 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 518.0
WH2_k127_2069894_10 adenyl ribonucleotide binding - - - 0.000000000000000000001019 102.0
WH2_k127_2069894_11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000000001342 93.0
WH2_k127_2069894_12 COG0642 Signal transduction histidine kinase - - - 0.00000000000008339 85.0
WH2_k127_2069894_13 Putative zinc- or iron-chelating domain K06940 - - 0.00000000009884 70.0
WH2_k127_2069894_14 Probable transposase K07496 - - 0.0000000001004 63.0
WH2_k127_2069894_15 Winged helix-turn-helix - - - 0.00003428 49.0
WH2_k127_2069894_2 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004021 282.0
WH2_k127_2069894_3 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002735 281.0
WH2_k127_2069894_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000002823 213.0
WH2_k127_2069894_5 methyltransferase small K07579 - - 0.00000000000000000000000000000000000000000000000000000003067 202.0
WH2_k127_2069894_6 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000000000009938 185.0
WH2_k127_2069894_7 RNA-binding protein of the translin family K07477 - - 0.00000000000000000000000000000000000000000000000001148 186.0
WH2_k127_2069894_8 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.00000000000000000000000000000000000000000000000005006 186.0
WH2_k127_2069894_9 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000007957 144.0
WH2_k127_2093830_0 Belongs to the glycosyl hydrolase 2 family - - - 0.000000000000000000000000000000000000000000000000000000006014 200.0
WH2_k127_2093830_1 Uncharacterized protein domain (DUF2202) - - - 0.0000000000000000000000000000000000000000000000001101 186.0
WH2_k127_2093830_2 Mediates zinc uptake. May also transport other divalent cations K07238 - - 0.0000000000000000000000000000000000000000000006607 171.0
WH2_k127_2119064_0 COG1404 Subtilisin-like serine proteases K09607 - - 4.53e-227 725.0
WH2_k127_2119064_1 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008697 256.0
WH2_k127_2119064_2 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000001477 164.0
WH2_k127_2119064_4 Domain of unknown function (DUF4130 K21929 - 3.2.2.27 0.0001062 51.0
WH2_k127_2133419_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004968 594.0
WH2_k127_2133419_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 545.0
WH2_k127_2133419_2 membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 405.0
WH2_k127_2133419_3 Domain of unknown function (DUF389) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003627 265.0
WH2_k127_2133419_4 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000165 183.0
WH2_k127_2133419_5 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000004276 128.0
WH2_k127_2133419_6 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.0000000000000005081 83.0
WH2_k127_2203361_0 Belongs to the RtcB family K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 428.0
WH2_k127_2203361_1 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.00000000000000000000000000000000000000000000000000000000000000005752 234.0
WH2_k127_2203361_2 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000000000000000000006251 190.0
WH2_k127_2212182_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 1.689e-287 894.0
WH2_k127_2212182_1 Ion channel - - - 0.000000002418 70.0
WH2_k127_2228774_0 TIGRFAM oligopeptide dipeptide ABC transporter K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009811 251.0
WH2_k127_2228774_1 Domain of unknown function DUF11 - - - 0.0000000000000000003682 102.0
WH2_k127_2228774_2 PFAM PUA domain containing protein K07398 - - 0.0005003 45.0
WH2_k127_2338400_0 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 394.0
WH2_k127_2338400_1 FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 343.0
WH2_k127_2338400_2 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000007833 191.0
WH2_k127_2338400_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000001388 159.0
WH2_k127_2345348_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 370.0
WH2_k127_2345348_1 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000000000001024 214.0
WH2_k127_2345348_2 Putative heavy-metal chelation - - - 0.000000000000000000000000000000000000000000000000000001393 201.0
WH2_k127_2345348_3 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000002326 180.0
WH2_k127_2345348_4 DNA-binding transcription factor activity K02444,K03655 - 3.6.4.12 0.00000000000000000000000000000000000000002445 163.0
WH2_k127_2345348_5 Protein of unknown function (DUF1670) - - - 0.0000000000000000000000000000000000006944 152.0
WH2_k127_2345348_6 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000001602 134.0
WH2_k127_2345348_7 PFAM elongation factor Tu domain 2 - - - 0.00000000000000000000000001084 110.0
WH2_k127_236875_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 3.12e-202 637.0
WH2_k127_236875_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007503 589.0
WH2_k127_236875_10 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008286 372.0
WH2_k127_236875_11 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 372.0
WH2_k127_236875_12 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000766 332.0
WH2_k127_236875_13 Tripartite tricarboxylate transporter TctA family K08971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005852 334.0
WH2_k127_236875_14 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007964 307.0
WH2_k127_236875_15 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 301.0
WH2_k127_236875_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 296.0
WH2_k127_236875_17 PFAM Bacterial transferase hexapeptide (three repeats) K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000749 263.0
WH2_k127_236875_18 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003458 252.0
WH2_k127_236875_19 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000393 245.0
WH2_k127_236875_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 553.0
WH2_k127_236875_20 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.0000000000000000000000000000000000000000000000000000000000000000005051 237.0
WH2_k127_236875_21 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000000000000001352 218.0
WH2_k127_236875_22 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000343 205.0
WH2_k127_236875_23 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000004158 175.0
WH2_k127_236875_24 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000024 168.0
WH2_k127_236875_25 DNA integration - - - 0.000000000000000000000000000000637 124.0
WH2_k127_236875_26 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.000000000000000000000000000001562 126.0
WH2_k127_236875_27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000517 96.0
WH2_k127_236875_28 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.0000000000000000007296 87.0
WH2_k127_236875_29 DNA integration - - - 0.0000000000003522 74.0
WH2_k127_236875_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 479.0
WH2_k127_236875_30 Glycosyl transferase 4-like - - - 0.000000006356 67.0
WH2_k127_236875_4 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006643 465.0
WH2_k127_236875_5 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 462.0
WH2_k127_236875_6 Beta-eliminating lyase K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009515 444.0
WH2_k127_236875_7 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007773 435.0
WH2_k127_236875_8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005147 417.0
WH2_k127_236875_9 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 377.0
WH2_k127_2385930_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 451.0
WH2_k127_2385930_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000001476 57.0
WH2_k127_2407912_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000038 325.0
WH2_k127_2407912_1 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000003639 266.0
WH2_k127_2407912_2 imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.0000000000000000000000000000000000000003622 155.0
WH2_k127_2407912_3 Protein of unknown function (DUF1638) - - - 0.000000000001542 72.0
WH2_k127_2416351_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 398.0
WH2_k127_2416351_1 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 308.0
WH2_k127_2416351_2 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000001893 206.0
WH2_k127_2421237_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 593.0
WH2_k127_2421237_1 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000435 264.0
WH2_k127_2421237_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000004989 196.0
WH2_k127_2421237_3 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000006862 183.0
WH2_k127_2421237_4 PFAM Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000001873 147.0
WH2_k127_2421237_5 Probable transposase K07496 - - 0.0000000000000000000000016 103.0
WH2_k127_246815_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 375.0
WH2_k127_246815_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 335.0
WH2_k127_246815_10 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.00000000000000000003462 89.0
WH2_k127_246815_11 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000004363 70.0
WH2_k127_246815_12 RNA binding K07581 - - 0.000000000000937 73.0
WH2_k127_246815_13 Predicted RNA-binding protein K06964 - - 0.0000000003857 62.0
WH2_k127_246815_14 Transcription factor Pcc1 K09741 - - 0.00000000194 61.0
WH2_k127_246815_15 Probably involved in the biogenesis of the ribosome K14561 - - 0.0000004049 57.0
WH2_k127_246815_2 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008228 330.0
WH2_k127_246815_3 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 329.0
WH2_k127_246815_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 285.0
WH2_k127_246815_5 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001463 260.0
WH2_k127_246815_6 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.000000000000000000000000000000000005092 139.0
WH2_k127_246815_7 binds to the 23S rRNA K02921 - - 0.00000000000000000000000000001554 119.0
WH2_k127_246815_8 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000000000000156 124.0
WH2_k127_246815_9 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000004081 107.0
WH2_k127_2482642_0 SMART Elongator protein 3 MiaB NifB K06936 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 307.0
WH2_k127_2482642_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000001478 214.0
WH2_k127_2482642_2 Protein of unknown function (DUF1646) - - - 0.000000000000000000000000000000000000000000324 164.0
WH2_k127_2482642_3 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000008293 156.0
WH2_k127_248889_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1394.0
WH2_k127_248889_1 SMART Elongator protein 3 MiaB NifB - - - 2.245e-278 866.0
WH2_k127_248889_10 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000837 132.0
WH2_k127_248889_11 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000003237 128.0
WH2_k127_248889_12 PFAM plasmid stabilization system - - - 0.000000000000000000000007736 103.0
WH2_k127_248889_13 Psort location Periplasmic, score 9.44 K07218 - - 0.00000000000000000006439 103.0
WH2_k127_248889_14 Transposase - - - 0.0000000000000000002882 89.0
WH2_k127_248889_15 Belongs to the acylphosphatase family - - - 0.0000000000003407 79.0
WH2_k127_248889_16 - - - - 0.000000004402 59.0
WH2_k127_248889_17 Protein of unknown function (DUF3795) - - - 0.0000008285 58.0
WH2_k127_248889_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 2.625e-274 855.0
WH2_k127_248889_3 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 423.0
WH2_k127_248889_4 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008867 406.0
WH2_k127_248889_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000917 372.0
WH2_k127_248889_6 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000004816 250.0
WH2_k127_248889_7 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000002596 223.0
WH2_k127_248889_8 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000001956 171.0
WH2_k127_248889_9 Putative cyclase K07130 - 3.5.1.9 0.0000000000000000000000000000000000000002939 158.0
WH2_k127_2498793_0 COG0444 ABC-type dipeptide oligopeptide nickel transport system ATPase component K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006105 295.0
WH2_k127_2498793_1 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000007464 165.0
WH2_k127_2508333_0 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 293.0
WH2_k127_2508333_1 PIN domain - - - 0.000000000000000000000000000000000000000000000000000000118 199.0
WH2_k127_2508333_2 - - - - 0.00000000000000000000001549 100.0
WH2_k127_2508333_3 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000001561 93.0
WH2_k127_2526187_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006758 326.0
WH2_k127_2526187_1 transport, permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001666 271.0
WH2_k127_2526187_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000343 212.0
WH2_k127_2526187_3 CGGC - - - 0.000000000000000000000000000000000000000000000000000001519 193.0
WH2_k127_2526187_4 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000006534 197.0
WH2_k127_2526187_5 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family - - - 0.00000000000000000000000006439 111.0
WH2_k127_2526187_6 Mediates zinc uptake. May also transport other divalent cations K07238 - - 0.000000000000001815 81.0
WH2_k127_256872_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1314.0
WH2_k127_256872_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 6.293e-303 937.0
WH2_k127_256872_10 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000002779 241.0
WH2_k127_256872_11 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000004423 233.0
WH2_k127_256872_12 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000002013 241.0
WH2_k127_256872_13 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000000000000000002285 219.0
WH2_k127_256872_14 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000001454 207.0
WH2_k127_256872_15 transcription termination protein NusA K02600 - - 0.00000000000000000000000000000000000000000000000000004821 190.0
WH2_k127_256872_16 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.0000000000000000000000001296 111.0
WH2_k127_256872_17 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.000000000000000000003564 94.0
WH2_k127_256872_2 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 3.795e-237 741.0
WH2_k127_256872_3 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 589.0
WH2_k127_256872_4 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005812 570.0
WH2_k127_256872_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 489.0
WH2_k127_256872_6 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 383.0
WH2_k127_256872_7 PFAM elongation factor Tu domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 384.0
WH2_k127_256872_8 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 294.0
WH2_k127_256872_9 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001372 256.0
WH2_k127_2576032_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004488 514.0
WH2_k127_2576032_1 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000007397 270.0
WH2_k127_2576032_2 Phospholipase D. Active site motifs. - - - 0.00000000000000000000000008845 124.0
WH2_k127_2581200_0 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 3.805e-260 808.0
WH2_k127_2581200_1 PFAM Glutamine amidotransferase, class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 518.0
WH2_k127_2581200_2 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008315 439.0
WH2_k127_2581200_3 GXGXG motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008375 269.0
WH2_k127_2581994_0 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009132 399.0
WH2_k127_25850_0 domain, Protein K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 534.0
WH2_k127_25850_1 COG0471 Di- and tricarboxylate transporters - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004943 514.0
WH2_k127_25850_2 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000006772 234.0
WH2_k127_25850_3 Sulphur transport K07112 - - 0.000000000000718 69.0
WH2_k127_2590764_0 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000000000000000001278 184.0
WH2_k127_2590764_1 TIGRFAM transposase, IS605 OrfB K07496 - - 0.000000000000000000000000000000000000000002525 161.0
WH2_k127_2590764_2 COG2897 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000001631 123.0
WH2_k127_2590764_3 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000008944 123.0
WH2_k127_2618860_0 PFAM Radical SAM domain protein K02585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 416.0
WH2_k127_2618860_1 AAA domain (Cdc48 subfamily) K07392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 406.0
WH2_k127_2618860_2 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 398.0
WH2_k127_2618860_3 SMART Elongator protein 3 MiaB NifB K22226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 358.0
WH2_k127_2618860_4 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000002426 248.0
WH2_k127_2618860_5 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.00000000000000000000000000000000000000000000000000002787 192.0
WH2_k127_2618860_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.000000000001962 70.0
WH2_k127_2624369_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000078 452.0
WH2_k127_2624369_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000275 424.0
WH2_k127_2624369_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008302 301.0
WH2_k127_2624369_3 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000006729 93.0
WH2_k127_2624369_4 PFAM Uncharacterised conserved protein UCP019262 - - - 0.000000000000000009958 91.0
WH2_k127_2624369_5 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000001419 70.0
WH2_k127_266276_0 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000004753 192.0
WH2_k127_266276_1 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000007408 187.0
WH2_k127_266276_2 - - - - 0.0000000000000000000000002291 113.0
WH2_k127_266276_3 Located on the platform of the 30S subunit K02948 - - 0.0000000000000000000002126 96.0
WH2_k127_266276_4 Located on the platform of the 30S subunit K02948 - - 0.000000000000000000005403 92.0
WH2_k127_2693176_0 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000009825 191.0
WH2_k127_2728067_0 CobN/Magnesium Chelatase K02230 - 6.6.1.2 0.0 1361.0
WH2_k127_2728067_1 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000003215 159.0
WH2_k127_274760_0 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005588 377.0
WH2_k127_274760_1 NAD(P)H dehydrogenase (quinone) K00355 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 292.0
WH2_k127_274760_2 regulatory protein, arsR - - - 0.00000000000000000000000000000000000000000000000000000000000000006317 231.0
WH2_k127_274760_3 MTH865-like family - - - 0.000000000000000000000000002066 112.0
WH2_k127_2800464_0 Sulfopyruvate decarboxylase K06034 GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019295,GO:0019296,GO:0044237,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0050545,GO:0051186,GO:0051188,GO:0071704,GO:1901576 4.1.1.79 0.000000000000000000000000000000000000000000000000000000001265 205.0
WH2_k127_2800464_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K13039 - 4.1.1.79 0.00000000000000000007185 92.0
WH2_k127_2800464_2 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.0000000000000002083 87.0
WH2_k127_2800464_3 Belongs to the GbsR family - - - 0.0000000006217 67.0
WH2_k127_2850355_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 436.0
WH2_k127_2850355_1 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 314.0
WH2_k127_2850355_2 PFAM Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 293.0
WH2_k127_2850355_3 Pfam:UPF0118 - - - 0.000000000001919 70.0
WH2_k127_2853365_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009521 369.0
WH2_k127_2853365_1 domain protein K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000005221 217.0
WH2_k127_2853365_2 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. - - - 0.0000000000000000000000000000000000000000000005071 181.0
WH2_k127_2853365_3 protein domain (DUF2202) - - - 0.0000000000000000000000002432 119.0
WH2_k127_2853365_4 TaqI-like C-terminal specificity domain - - - 0.0000000000005495 71.0
WH2_k127_2880822_0 Alkyl sulfatase dimerisation - - - 2.153e-303 942.0
WH2_k127_2880822_1 PFAM Cache, type 2 domain protein - - - 0.00000000000000000000000000000000001093 139.0
WH2_k127_2880822_2 Uncharacterized conserved protein (DUF2196) - - - 0.000000000000000000000004033 103.0
WH2_k127_2942512_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 599.0
WH2_k127_2942512_1 Proton-conducting membrane transporter K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 513.0
WH2_k127_2942512_2 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 356.0
WH2_k127_2942512_3 Protein of unknown function (DUF1646) - - - 0.00000001468 60.0
WH2_k127_2942512_4 - - - - 0.00008087 49.0
WH2_k127_2959364_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 343.0
WH2_k127_2959364_1 PFAM Leucine rich repeat variant - - - 0.000000000000000000000000000000000001012 149.0
WH2_k127_2959364_2 eRF1 domain 2 - - - 0.00000000000000000000001508 112.0
WH2_k127_2959364_3 Pfam:Nol1_Nop2_Fmu_2 - - - 0.00000000000000000001465 96.0
WH2_k127_2959364_4 Belongs to the UPF0248 family K09715 - - 0.000000000000000003317 86.0
WH2_k127_302389_0 COG0464 ATPases of the AAA class K13525 - - 2.27e-322 1000.0
WH2_k127_302389_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005009 571.0
WH2_k127_302389_2 Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 415.0
WH2_k127_302389_3 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 348.0
WH2_k127_302389_4 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000001465 237.0
WH2_k127_302389_5 PFAM PRC-barrel domain - - - 0.000000000000000001947 88.0
WH2_k127_302389_6 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0000000342 56.0
WH2_k127_302389_7 - - - - 0.000000457 55.0
WH2_k127_3025156_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 332.0
WH2_k127_3025156_1 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000002161 214.0
WH2_k127_3025156_2 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000005694 182.0
WH2_k127_3025156_3 Nucleotidyltransferase domain - - - 0.000000000000000003269 88.0
WH2_k127_3089026_0 PFAM Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005735 547.0
WH2_k127_3089026_1 Male sterility protein K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009724 482.0
WH2_k127_3089026_2 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009889 484.0
WH2_k127_3089026_3 TIGRFAM dTDP-4-dehydrorhamnose reductase K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 398.0
WH2_k127_3089026_4 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 332.0
WH2_k127_3089026_5 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 286.0
WH2_k127_3089026_6 glycosyltransferase - - - 0.0000000000000000000000000000000000000000000000000007059 197.0
WH2_k127_3089026_7 PFAM Glycosyl transferase, group 1 K12996 GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.000000000000000000003564 94.0
WH2_k127_3145862_0 CobN/Magnesium Chelatase K02230 - 6.6.1.2 0.0 1407.0
WH2_k127_3145862_1 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 330.0
WH2_k127_3145862_2 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000008038 185.0
WH2_k127_3145862_3 PFAM PUA domain containing protein K07398 - - 0.0003852 45.0
WH2_k127_3171484_0 glycosyltransferase 36 associated K00702,K13688 - 2.4.1.20 0.0 3265.0
WH2_k127_3171484_1 Putative small multi-drug export protein - - - 0.0000000000000000000000000000000000000000000000005627 179.0
WH2_k127_3196176_0 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000005783 231.0
WH2_k127_3196176_1 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000002069 222.0
WH2_k127_3196176_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.0000001244 57.0
WH2_k127_3196176_3 Periplasmic binding protein K02016 - - 0.00001049 50.0
WH2_k127_3215174_0 KH, type 1, domain K07041 - - 1.923e-312 967.0
WH2_k127_3215174_1 DEAD DEAH box helicase domain protein K03725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 365.0
WH2_k127_3215174_2 SMART regulatory protein, Crp K07730 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 333.0
WH2_k127_3215174_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000004081 257.0
WH2_k127_3215174_4 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000005201 231.0
WH2_k127_3215174_5 ArsR transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000002511 184.0
WH2_k127_3224994_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.336e-237 747.0
WH2_k127_3224994_1 Sodium:solute symporter family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 544.0
WH2_k127_3224994_2 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005805 331.0
WH2_k127_3224994_3 Belongs to the eukaryotic ribosomal protein eS6 family K02991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.0000001712 53.0
WH2_k127_3228276_0 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000002765 201.0
WH2_k127_3228276_1 - - - - 0.0000000000000000001592 94.0
WH2_k127_3228276_2 - - - - 0.000000000000000009446 85.0
WH2_k127_3233837_0 COG1002 Type II restriction enzyme, methylase subunits - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 447.0
WH2_k127_3233837_1 PFAM ABC transporter related K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 300.0
WH2_k127_3233837_2 COG0668 Small-conductance mechanosensitive channel K16052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000178 248.0
WH2_k127_3233837_3 PFAM phosphoesterase, PA-phosphatase related K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000009391 243.0
WH2_k127_3233837_4 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000399 195.0
WH2_k127_3233837_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.00000000000000000000000000000000000007595 146.0
WH2_k127_3261927_0 AAA family ATPase, CDC48 subfamily K13525 - - 1.588e-296 928.0
WH2_k127_3261927_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.882e-275 861.0
WH2_k127_3261927_2 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 477.0
WH2_k127_3261927_3 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000001966 252.0
WH2_k127_3261927_4 Catalyzes the insertion of Co(2 ) into sirohydrochlorin K02190 - 4.99.1.3 0.0000000000000000000000000000000000000000002531 170.0
WH2_k127_3261927_5 PFAM Carboxymuconolactone decarboxylase - - - 0.00000000000000000000000000000000000006047 146.0
WH2_k127_3261927_6 PFAM regulatory protein, ArsR K07721 - - 0.00000000000000000000000000000002335 134.0
WH2_k127_3261927_7 - - - - 0.00000000000002505 78.0
WH2_k127_3261927_8 Nuclease (SNase domain-containing protein) - - - 0.0000000000008175 78.0
WH2_k127_3267193_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 497.0
WH2_k127_3267193_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 317.0
WH2_k127_3267193_2 ADP-specific Phosphofructokinase/Glucokinase conserved region K00918 - 2.7.1.146,2.7.1.147 0.00000000000000000000000000000000000000000000000006858 191.0
WH2_k127_3267193_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000000000000000000000000000000000007283 143.0
WH2_k127_3267193_4 Possibly the antitoxin component of a - - - 0.000000000005925 70.0
WH2_k127_3271633_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009801 340.0
WH2_k127_3271633_1 mRNA binding - - - 0.00000000000000003311 83.0
WH2_k127_3271633_2 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000002168 81.0
WH2_k127_3271633_3 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000003003 78.0
WH2_k127_3271633_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000003124 58.0
WH2_k127_3271633_5 Protein of unknown function DUF104 - - - 0.00004024 51.0
WH2_k127_3273265_0 NADH ubiquinone oxidoreductase, NADH-binding K00124,K00335,K18331 - 1.12.1.3,1.6.5.3 1.122e-262 822.0
WH2_k127_3273265_1 PFAM Aminotransferase class I and II K00812,K10907,K14287 - 2.6.1.1,2.6.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009894 537.0
WH2_k127_3273265_10 - K00960 - 2.7.7.6 0.0000000000000003906 80.0
WH2_k127_3273265_11 - - - - 0.0000000000009653 72.0
WH2_k127_3273265_12 Heavy metal transport detoxification protein K17686 - 3.6.3.54 0.0000000162 59.0
WH2_k127_3273265_2 TIGRFAM lysine 2,3-aminomutase YodO family protein K01843 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000694 504.0
WH2_k127_3273265_3 His Kinase A (phospho-acceptor) domain K11443 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006061 433.0
WH2_k127_3273265_4 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 308.0
WH2_k127_3273265_5 PFAM Appr-1-p processing - - - 0.00000000000000000000000000000000000000000000000000000000000000003394 227.0
WH2_k127_3273265_6 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000001762 206.0
WH2_k127_3273265_7 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000007781 175.0
WH2_k127_3273265_8 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000005352 151.0
WH2_k127_3273265_9 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441 - 1.12.98.1 0.00000000000000000000000000000457 135.0
WH2_k127_331779_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006289 587.0
WH2_k127_331779_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 461.0
WH2_k127_331779_10 Belongs to the UPF0216 family K09737 - - 0.000000000000005108 79.0
WH2_k127_331779_11 Belongs to the eukaryotic ribosomal protein eS17 family K02962 - - 0.0000000000001612 73.0
WH2_k127_331779_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008811 380.0
WH2_k127_331779_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 344.0
WH2_k127_331779_4 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 338.0
WH2_k127_331779_5 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 324.0
WH2_k127_331779_6 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007179 280.0
WH2_k127_331779_7 amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000001707 199.0
WH2_k127_331779_8 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000002972 141.0
WH2_k127_331779_9 - - - - 0.0000000000000006731 84.0
WH2_k127_3352797_0 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000000000000000003902 238.0
WH2_k127_3352797_1 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000001823 236.0
WH2_k127_3352797_2 Peptidase C14 caspase catalytic subunit p20 - - - 0.000000000002442 79.0
WH2_k127_3352797_3 Probable transposase K07496 - - 0.0000000002613 61.0
WH2_k127_3420269_0 C-terminal region of MMR_HSR1 domain K06944 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009879 430.0
WH2_k127_3420269_1 by modhmm K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008639 302.0
WH2_k127_3420269_2 Domain of unknown function DUF83 K07464 - 3.1.12.1 0.000000000000000000000000000007281 128.0
WH2_k127_3420269_3 - - - - 0.0000000000000000000000002503 115.0
WH2_k127_3446707_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 572.0
WH2_k127_3446707_1 Aconitase family (aconitate hydratase) K01681 - 4.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005494 541.0
WH2_k127_3446707_2 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 443.0
WH2_k127_3446707_3 - - - - 0.00000000000000000000000000000008285 130.0
WH2_k127_3446707_4 DNA methylase K00571,K07316 - 2.1.1.72 0.000000000000000000007138 95.0
WH2_k127_3446707_5 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000005005 71.0
WH2_k127_3446707_6 - - - - 0.000000000003718 72.0
WH2_k127_3446707_7 mRNA binding - - - 0.0000003456 54.0
WH2_k127_344804_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 526.0
WH2_k127_344804_1 ATPases associated with a variety of cellular activities K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 332.0
WH2_k127_344804_2 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002008 290.0
WH2_k127_344804_3 ABC-2 type transporter K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009223 279.0
WH2_k127_344804_4 Bacterial transferase hexapeptide repeat K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000004395 175.0
WH2_k127_344804_5 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000006402 164.0
WH2_k127_344804_6 B12 binding domain - - - 0.00000000000000006969 85.0
WH2_k127_344804_7 Transposase domain (DUF772) K07481 - - 0.0000000000001404 72.0
WH2_k127_3450892_0 TspO/MBR family K05770 - - 0.00000000000000000000000000000000000000000000000003161 184.0
WH2_k127_3450892_1 domain protein - - - 0.000000000000000000000000000000005887 149.0
WH2_k127_3450892_2 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.00000000002486 66.0
WH2_k127_3531517_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 2.031e-235 748.0
WH2_k127_3531517_1 PFAM AIR synthase related protein K07123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 364.0
WH2_k127_3531517_2 methyltransferase activity - - - 0.000000000000000000000000000000000000000000001714 174.0
WH2_k127_3531517_3 DNA-binding protein with PD1-like DNA-binding motif K06934 - - 0.00000000000000000000000000004413 121.0
WH2_k127_3534412_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1022.0
WH2_k127_3534412_1 PFAM multi antimicrobial extrusion protein MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 535.0
WH2_k127_3534412_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 381.0
WH2_k127_3534412_3 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 341.0
WH2_k127_3534412_4 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007074 328.0
WH2_k127_3534412_5 Putative RNA methyltransferase K09142 - - 0.0000000000000000000000000000000000000000000000000000000000000000000281 242.0
WH2_k127_3534412_6 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000001198 231.0
WH2_k127_3534412_7 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.0000000000000000000004725 98.0
WH2_k127_3534412_8 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000001513 63.0
WH2_k127_3534412_9 - - - - 0.0000001474 61.0
WH2_k127_3544687_0 Protein of unknown function, DUF255 K06888 - - 1.619e-241 765.0
WH2_k127_3544687_1 aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 550.0
WH2_k127_3544687_10 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000004649 83.0
WH2_k127_3544687_11 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000005013 81.0
WH2_k127_3544687_2 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 421.0
WH2_k127_3544687_3 PFAM glutamate--cysteine ligase, GCS2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004191 406.0
WH2_k127_3544687_4 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005191 338.0
WH2_k127_3544687_5 RimK-like ATPgrasp N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000003283 216.0
WH2_k127_3544687_6 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000003714 148.0
WH2_k127_3544687_7 Domain of unknown function (DUF4258) - - - 0.0000000000000000000007638 98.0
WH2_k127_3544687_8 mRNA binding - - - 0.000000000000000000001286 95.0
WH2_k127_3544687_9 - - - - 0.0000000000000000002913 93.0
WH2_k127_3558076_0 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 376.0
WH2_k127_3558076_1 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.0000000000000000000000000000000000000000000000007383 179.0
WH2_k127_3558076_2 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00582 - 2.1.1.86 0.000000000001792 70.0
WH2_k127_3558076_3 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00583 - 2.1.1.86 0.00000000001318 67.0
WH2_k127_3558076_4 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.0000000000652 72.0
WH2_k127_3578763_0 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 297.0
WH2_k127_3578763_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000002261 170.0
WH2_k127_3578763_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000000000000001061 103.0
WH2_k127_3578763_3 PKD domain - - - 0.00000009327 64.0
WH2_k127_3625899_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 603.0
WH2_k127_3625899_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 541.0
WH2_k127_3625899_2 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 423.0
WH2_k127_3625899_3 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 306.0
WH2_k127_3625899_4 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0000000000000000000000000000000000000000000000001059 179.0
WH2_k127_3646642_0 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000004394 248.0
WH2_k127_3646642_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000001038 156.0
WH2_k127_3667273_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 559.0
WH2_k127_3667273_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000005577 257.0
WH2_k127_3667661_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006745 304.0
WH2_k127_3667661_1 Homeodomain-like domain K06933 - - 0.0000000000000000000001574 103.0
WH2_k127_3667661_2 Family of unknown function (DUF5320) - - - 0.0009201 45.0
WH2_k127_367026_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000001218 214.0
WH2_k127_367026_1 Protein of unknown function (DUF1699) - - - 0.00000000000000000000000000000000000000001439 157.0
WH2_k127_367026_2 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity K00549 - 2.1.1.14 0.000000000000000000007812 94.0
WH2_k127_367026_3 receptor K17768 GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005742,GO:0006605,GO:0006626,GO:0006810,GO:0006839,GO:0006886,GO:0006996,GO:0007005,GO:0007006,GO:0007007,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0017038,GO:0019867,GO:0030150,GO:0030943,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031306,GO:0031307,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032592,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044743,GO:0045039,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072655,GO:0072657,GO:0090150,GO:0090151,GO:0098573,GO:0098588,GO:0098796,GO:0098798,GO:0098799,GO:0098805,GO:1990542 - 0.00000003059 62.0
WH2_k127_3671632_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 394.0
WH2_k127_3671632_1 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000000000000007762 174.0
WH2_k127_3671632_2 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000003186 146.0
WH2_k127_3671632_3 Right handed beta helix region - - - 0.00000000000000000000000000000000001604 156.0
WH2_k127_3674661_0 PFAM Major facilitator superfamily - - - 0.000000000000000003947 87.0
WH2_k127_3674661_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000005732 86.0
WH2_k127_3674661_2 Belongs to the GbsR family K22109 - - 0.000000064 63.0
WH2_k127_3674679_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 556.0
WH2_k127_3674679_1 PFAM PUA domain containing protein K07398 - - 0.000000000000000000000000000000000000000003603 160.0
WH2_k127_3674679_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000185 93.0
WH2_k127_3674679_3 - - - - 0.0001036 50.0
WH2_k127_3679846_0 VWA domain containing CoxE-like protein K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 595.0
WH2_k127_3679846_1 Predicted metal-binding protein (DUF2284) - - - 0.0000000000000000000000000000000000000000000000000001501 192.0
WH2_k127_3679846_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000008899 142.0
WH2_k127_3679846_3 phosphorelay signal transduction system - - - 0.0000000000000001156 85.0
WH2_k127_3699547_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 333.0
WH2_k127_3699547_1 Domain of unknown function (DUF1743) - - - 0.0000000000000000000000000000000002704 134.0
WH2_k127_3793288_0 Cobalt transport protein K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000992 441.0
WH2_k127_3793288_1 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 360.0
WH2_k127_3793288_2 PDGLE domain K02007,K02009 - - 0.00000000000000000000000000000000000000003625 153.0
WH2_k127_3793288_3 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.00000000353 58.0
WH2_k127_3799746_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008057 561.0
WH2_k127_3799746_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 541.0
WH2_k127_3799746_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773,K18779 - 2.4.2.29,2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 448.0
WH2_k127_3799746_3 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 353.0
WH2_k127_3799746_4 PFAM Methyltransferase type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 300.0
WH2_k127_3799746_5 nucleoside recognition domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000002263 238.0
WH2_k127_3799746_6 Ferritin-like domain K02217 - 1.16.3.2 0.0000000000000000000000000000000000000000000005243 172.0
WH2_k127_3799746_7 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000000000000000000000000000002223 133.0
WH2_k127_3799746_8 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.000000000000000000000004265 102.0
WH2_k127_3799746_9 Secreted repeat of unknown function - - - 0.000000000000000000002493 99.0
WH2_k127_3825053_0 involved in the export of O-antigen and teichoic acid - - - 0.0000000000000000000000000000000000000000000000000003438 193.0
WH2_k127_3850389_0 Met-10+ like-protein K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 286.0
WH2_k127_396608_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 587.0
WH2_k127_396608_1 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 394.0
WH2_k127_396608_10 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000002137 161.0
WH2_k127_396608_11 Transcriptional regulator, TrmB - - - 0.000000000000000000000000000000000004942 141.0
WH2_k127_396608_12 - - - - 0.0000000005397 69.0
WH2_k127_396608_13 FeoA K04758 - - 0.0000000006493 63.0
WH2_k127_396608_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 342.0
WH2_k127_396608_3 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 335.0
WH2_k127_396608_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001125 278.0
WH2_k127_396608_5 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004077 279.0
WH2_k127_396608_6 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000379 230.0
WH2_k127_396608_7 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.0000000000000000000000000000000000000000000000000000000000000001353 229.0
WH2_k127_396608_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000004622 208.0
WH2_k127_396608_9 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000007138 174.0
WH2_k127_4037218_0 PFAM Pyridoxal-dependent decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 479.0
WH2_k127_4037218_1 RibD C-terminal domain K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000009401 220.0
WH2_k127_4037218_2 Stage II sporulation protein E K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000003555 229.0
WH2_k127_4037218_3 PFAM Transposase, IS204 IS1001 IS1096 IS1165 K07485 - - 0.0000000000000000000000005365 105.0
WH2_k127_4037218_4 - - - - 0.00000000000000000000003818 99.0
WH2_k127_4037218_5 - - - - 0.000000001336 62.0
WH2_k127_4068794_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 4.47e-234 752.0
WH2_k127_4068794_1 PFAM PilT protein domain protein K06865 - - 2.465e-215 684.0
WH2_k127_4068794_10 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000707 114.0
WH2_k127_4068794_11 Protein of unknown function (DUF2551) - - - 0.000000000000000000004524 96.0
WH2_k127_4068794_12 TIGRFAM transposase, IS605 OrfB family K07496 - - 0.00000000000000000003759 95.0
WH2_k127_4068794_13 Cna B domain protein - - - 0.0000000000001341 76.0
WH2_k127_4068794_2 PFAM AIR synthase related protein K07388 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 591.0
WH2_k127_4068794_3 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 565.0
WH2_k127_4068794_4 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 340.0
WH2_k127_4068794_5 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008509 337.0
WH2_k127_4068794_6 - - - - 0.00000000000000000000000000000000000000000000000005952 180.0
WH2_k127_4068794_7 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000000003965 165.0
WH2_k127_4068794_8 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000008242 153.0
WH2_k127_4068794_9 - - - - 0.0000000000000000000000000000000000001649 144.0
WH2_k127_4108098_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 3.723e-262 822.0
WH2_k127_4108098_1 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 2.572e-197 633.0
WH2_k127_4108098_10 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000001226 222.0
WH2_k127_4108098_11 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000003573 214.0
WH2_k127_4108098_12 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000002511 183.0
WH2_k127_4108098_13 tRNA m6t6A37 methyltransferase activity K01628,K11261 - 1.2.7.12,4.1.2.17 0.00000000000000000000000000000000000000000000007438 172.0
WH2_k127_4108098_14 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.0000000000000000000000000000001306 138.0
WH2_k127_4108098_15 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.0000000000000363 75.0
WH2_k127_4108098_16 - - - - 0.000000000001965 71.0
WH2_k127_4108098_17 COG1361 S-layer domain - - - 0.00000000006798 73.0
WH2_k127_4108098_18 Nitrate reductase gamma subunit K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000007194 59.0
WH2_k127_4108098_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 582.0
WH2_k127_4108098_3 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 476.0
WH2_k127_4108098_4 PFAM Binding-protein-dependent transport K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009417 404.0
WH2_k127_4108098_5 ATPases associated with a variety of cellular activities K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 288.0
WH2_k127_4108098_6 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003099 284.0
WH2_k127_4108098_7 TIGRFAM F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006955 271.0
WH2_k127_4108098_8 ABC-3 protein K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000633 248.0
WH2_k127_4108098_9 ABC-type metal ion transport system periplasmic component surface adhesin K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003267 249.0
WH2_k127_4199807_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 485.0
WH2_k127_4199807_1 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 323.0
WH2_k127_4199807_10 hydrolase (metallo-beta-lactamase superfamily) K02238 - - 0.00001111 56.0
WH2_k127_4199807_2 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000184 267.0
WH2_k127_4199807_3 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000411 261.0
WH2_k127_4199807_4 Domain of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001842 252.0
WH2_k127_4199807_5 Fumarase C-terminus K01678 - 4.2.1.2 0.000000000000000000000000000000000000000000000001248 182.0
WH2_k127_4199807_6 Belongs to the UPF0215 family K09120 - - 0.00000000000000000000000000000000000000000000106 172.0
WH2_k127_4199807_7 Protein of unknown function (DUF434) - - - 0.00000000000000000000000000000000007529 144.0
WH2_k127_4199807_8 Acylphosphatase K01512 - 3.6.1.7 0.00000000006015 72.0
WH2_k127_4199807_9 domain, Protein - - - 0.0000003202 63.0
WH2_k127_4202865_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 490.0
WH2_k127_4202865_1 AAA domain K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003263 272.0
WH2_k127_4210326_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 350.0
WH2_k127_4210326_1 NmrA-like family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 338.0
WH2_k127_4238405_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 577.0
WH2_k127_4238405_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000304 281.0
WH2_k127_4238405_2 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000229 235.0
WH2_k127_4238405_3 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000003801 231.0
WH2_k127_4238405_4 TIGRFAM transposase, IS605 OrfB family, central region - - - 0.00000000000000000000000000000000000000000000000000000000005064 220.0
WH2_k127_4238405_5 ABC-2 family transporter protein K01992 - - 0.000000000000006343 76.0
WH2_k127_4274637_0 PFAM Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 359.0
WH2_k127_4274637_1 HicA toxin of bacterial toxin-antitoxin, - - - 0.000000000000000004777 85.0
WH2_k127_4274637_2 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000002745 76.0
WH2_k127_4274637_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00003364 46.0
WH2_k127_4280193_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 5.415e-197 620.0
WH2_k127_4280193_1 PFAM amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000000000000000000009769 171.0
WH2_k127_4280193_2 - - - - 0.000000005066 61.0
WH2_k127_4280193_3 - - - - 0.000002042 53.0
WH2_k127_4301422_0 Belongs to the catalase family K03781 - 1.11.1.6 2.38e-287 887.0
WH2_k127_4301422_1 Probable transposase K07496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 308.0
WH2_k127_4301422_2 PFAM Rubrerythrin - GO:0003674,GO:0003824,GO:0004601,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0022900,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002469 274.0
WH2_k127_4301422_3 Universal stress protein family - - - 0.000000000000000000000000007955 115.0
WH2_k127_4303038_0 PFAM Thiolase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 533.0
WH2_k127_4303038_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 516.0
WH2_k127_4303038_2 Helix-turn-helix domain protein K07731 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004811 256.0
WH2_k127_4303038_3 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000003818 185.0
WH2_k127_4303038_4 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.0000000000000000000000000000000000000000000000002018 180.0
WH2_k127_4324156_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 342.0
WH2_k127_4324156_1 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002133 281.0
WH2_k127_4324156_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000001366 210.0
WH2_k127_4324156_3 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000001747 171.0
WH2_k127_4354340_0 S-layer protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 592.0
WH2_k127_4354340_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 346.0
WH2_k127_4354340_2 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003728 266.0
WH2_k127_4354340_3 - - - - 0.00000000000000000000000000003384 120.0
WH2_k127_4354340_4 Nuclease (SNase domain-containing protein) - - - 0.0000003848 59.0
WH2_k127_4354340_5 Cation transporter/ATPase, N-terminus K01537,K12953 GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.8 0.000001215 53.0
WH2_k127_4364238_0 PFAM Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004703 584.0
WH2_k127_4364238_1 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 557.0
WH2_k127_4364238_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003401 485.0
WH2_k127_4364238_3 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009348 352.0
WH2_k127_4364238_4 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000001835 189.0
WH2_k127_4364238_5 Putative auto-transporter adhesin, head GIN domain - - - 0.00000000000000000000000000007291 125.0
WH2_k127_4364238_6 Phytol kinase K15892,K18678 - 2.7.1.182,2.7.1.216 0.000000001192 67.0
WH2_k127_4364238_7 Laminin-type epidermal growth factor-like domai K06240 GO:0001704,GO:0001706,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005604,GO:0005605,GO:0005608,GO:0005610,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005911,GO:0005912,GO:0005913,GO:0007044,GO:0007155,GO:0007275,GO:0007369,GO:0007492,GO:0008150,GO:0008544,GO:0009653,GO:0009790,GO:0009888,GO:0009987,GO:0012505,GO:0016043,GO:0022607,GO:0022610,GO:0030054,GO:0030055,GO:0030056,GO:0030154,GO:0030198,GO:0031012,GO:0031581,GO:0032501,GO:0032502,GO:0032991,GO:0034329,GO:0034330,GO:0035987,GO:0043062,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043256,GO:0044085,GO:0044420,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0048598,GO:0048646,GO:0048856,GO:0048869,GO:0062023,GO:0070161,GO:0071840,GO:0098609 - 0.0001452 49.0
WH2_k127_43661_0 alpha amylase, C-terminal all-beta - - - 2.162e-267 836.0
WH2_k127_43661_1 MarR family - - - 0.000000000000000000000000000000000000004361 151.0
WH2_k127_43661_2 Thioredoxin K03671 - - 0.00000000000000000000000000000000000001355 155.0
WH2_k127_43661_3 Protein of unknown function (DUF1638) - - - 0.000000000000000000000000000003256 126.0
WH2_k127_43661_4 - - - - 0.00000000000000000000000004144 113.0
WH2_k127_4443914_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 608.0
WH2_k127_4443914_1 Mn2 dependent serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 429.0
WH2_k127_4443914_10 - - - - 0.0000000000000000000000000000000000001738 148.0
WH2_k127_4443914_11 Non-histone chromosomal protein MC1 - - - 0.00000000000000000000000000006681 118.0
WH2_k127_4443914_12 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000004458 113.0
WH2_k127_4443914_13 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000106 70.0
WH2_k127_4443914_14 Putative Fe-S cluster - - - 0.000000007512 61.0
WH2_k127_4443914_15 Winged helix-turn-helix - - - 0.00000001037 59.0
WH2_k127_4443914_2 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 373.0
WH2_k127_4443914_3 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006097 373.0
WH2_k127_4443914_4 RNA methylase K07446 - 2.1.1.213 0.00000000000000000000000000000000000000000000000000000000000000000000000000003393 270.0
WH2_k127_4443914_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002322 252.0
WH2_k127_4443914_6 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001629 244.0
WH2_k127_4443914_7 Transcription elongation factor Spt5 K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000002047 229.0
WH2_k127_4443914_8 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000000000000000000000002466 204.0
WH2_k127_4443914_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000001226 181.0
WH2_k127_4497210_0 TIGRFAM TraB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 388.0
WH2_k127_4497210_1 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006136 325.0
WH2_k127_4497210_2 Serine protease with a broad substrate specificity K17734 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000002746 242.0
WH2_k127_4497210_3 PFAM Class II Aldolase K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000002676 174.0
WH2_k127_4497210_4 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000003243 164.0
WH2_k127_4497210_5 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.0000000000000000000005676 98.0
WH2_k127_4506541_0 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 414.0
WH2_k127_4506541_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001126 253.0
WH2_k127_4506541_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000000533 76.0
WH2_k127_4525119_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 439.0
WH2_k127_4525119_1 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003842 243.0
WH2_k127_4525119_2 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000000001249 189.0
WH2_k127_4525119_3 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000002735 169.0
WH2_k127_4525119_4 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000000004175 127.0
WH2_k127_4525119_5 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000009502 116.0
WH2_k127_4525119_6 PFAM TM2 domain containing protein - - - 0.0009916 48.0
WH2_k127_4526620_0 TIGRFAM archaeoflavoprotein AfpA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000409 236.0
WH2_k127_4526620_1 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.00000000000000000000000000000000000000000000000000000000001222 222.0
WH2_k127_4526620_2 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000004716 123.0
WH2_k127_4526620_3 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.000000000000000000000000000005284 124.0
WH2_k127_4526620_4 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.00000000000000000000000000001577 119.0
WH2_k127_4561828_0 Protein of unknown function (DUF3696) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000537 234.0
WH2_k127_4561828_1 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000155 219.0
WH2_k127_4561828_2 - - - - 0.000000000000000000000003559 109.0
WH2_k127_4564426_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 494.0
WH2_k127_4564426_1 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 383.0
WH2_k127_4564426_10 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.00000000468 64.0
WH2_k127_4564426_2 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 378.0
WH2_k127_4564426_3 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 309.0
WH2_k127_4564426_4 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 295.0
WH2_k127_4564426_5 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002324 234.0
WH2_k127_4564426_6 Necessary for normal cell division and for the maintenance of normal septation - - - 0.00000000000000000000000000000000000000000000000000000001382 211.0
WH2_k127_4564426_7 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000005561 200.0
WH2_k127_4564426_8 COG0668 Small-conductance mechanosensitive channel K16052 - - 0.00000000000000000000000000000000000000000000005399 181.0
WH2_k127_4564426_9 PBS lyase HEAT-like repeat - - - 0.0000000000000002296 90.0
WH2_k127_4568499_0 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000838 200.0
WH2_k127_4568499_1 Non-histone chromosomal protein MC1 - - - 0.00000000000000000000000000006367 119.0
WH2_k127_4568499_2 Periplasmic binding protein K02016 - - 0.00000000000000001184 87.0
WH2_k127_4568499_3 Belongs to the BshC family K22136 - - 0.000000000000382 72.0
WH2_k127_4604927_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 2.791e-226 710.0
WH2_k127_4604927_1 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 485.0
WH2_k127_4607708_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1243.0
WH2_k127_4671_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.0 1014.0
WH2_k127_4671_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 344.0
WH2_k127_4671_2 Belongs to the acylphosphatase family - - - 0.0000000000000000001217 96.0
WH2_k127_4671_3 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000295 69.0
WH2_k127_4671_4 PFAM acylphosphatase K01512 - 3.6.1.7 0.000001522 55.0
WH2_k127_4671_5 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00008661 46.0
WH2_k127_4738516_0 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 483.0
WH2_k127_4738516_1 Putative Fe-S cluster - - - 0.000000000000000000000000000000000000000000000000006272 183.0
WH2_k127_4738516_2 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.0000000000000000000000000000000000035 141.0
WH2_k127_4738516_3 cytochrome c biogenesis protein, transmembrane region K06196 - - 0.000000002388 70.0
WH2_k127_4738516_4 COG2897 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000009788 63.0
WH2_k127_4738516_5 Catalyzes the reduction of the disulfide bonds in the heme binding site of apocytochrome c - GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.0009088 51.0
WH2_k127_4740351_0 Protein of unknown function (DUF1016) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 473.0
WH2_k127_4740351_1 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000005728 235.0
WH2_k127_4740351_2 PFAM Type I restriction modification DNA specificity domain K01154 - 3.1.21.3 0.000000000000000000000000000000000000000000000000000000000000002716 227.0
WH2_k127_4740351_3 Dihydrouridine synthase (Dus) - - - 0.00000000000000000000000000000000000000000000000000000000003256 215.0
WH2_k127_4740351_4 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000001152 201.0
WH2_k127_4740351_5 Protein of unknown function (DUF447) K09154 - - 0.00000000000000000000000000000004728 134.0
WH2_k127_4740351_6 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000003128 114.0
WH2_k127_4745864_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 482.0
WH2_k127_4745864_1 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002243 264.0
WH2_k127_4754246_0 PFAM oxidoreductase nitrogenase, component 1 K02586 - 1.18.6.1 1.778e-244 758.0
WH2_k127_4754246_1 Belongs to the NifD NifK NifE NifN family K02587 - - 1.626e-195 619.0
WH2_k127_4754246_2 PFAM oxidoreductase nitrogenase, component 1 K02591 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 472.0
WH2_k127_4754246_3 Belongs to the NifD NifK NifE NifN family K02592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006258 447.0
WH2_k127_4754246_4 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 334.0
WH2_k127_4754246_5 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 312.0
WH2_k127_4754246_6 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 302.0
WH2_k127_4754246_7 ATPases associated with a variety of cellular activities K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000001687 243.0
WH2_k127_4754246_8 S-layer protein - - - 0.000000000000001662 91.0
WH2_k127_4768086_0 - K19200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 309.0
WH2_k127_4768086_1 GrpB protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004182 275.0
WH2_k127_4768086_2 serine-type aminopeptidase activity K02030,K14475 - - 0.00000000000001022 83.0
WH2_k127_4847918_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 507.0
WH2_k127_4847918_1 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 330.0
WH2_k127_4847918_2 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 294.0
WH2_k127_4847918_3 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000002125 223.0
WH2_k127_4847918_4 Transcriptional regulator, TrmB - - - 0.000000000000000000000000001513 117.0
WH2_k127_4847918_5 protein conserved in archaea - - - 0.000000000000000000000000008395 112.0
WH2_k127_4858550_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008471 464.0
WH2_k127_4858550_1 Metallo-beta-lactamase domain protein K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 424.0
WH2_k127_4858550_2 PFAM Conserved TM helix repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 421.0
WH2_k127_4858550_3 Uncharacterized protein family (UPF0051) K07033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 398.0
WH2_k127_4858550_4 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009951 293.0
WH2_k127_4858550_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000656 170.0
WH2_k127_4858550_6 ester cyclase - - - 0.000000000000000000000000000077 120.0
WH2_k127_4858550_7 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.00000000005405 67.0
WH2_k127_4858550_8 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000005209 61.0
WH2_k127_4864796_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 336.0
WH2_k127_4864796_1 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000007751 183.0
WH2_k127_4864796_2 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.000000000000000000000000000000000000000006103 159.0
WH2_k127_4864796_3 metal ion binding - - - 0.0000000000000000000000003325 110.0
WH2_k127_4864796_4 Belongs to the UPF0235 family K09131 - - 0.0000000000000000001643 92.0
WH2_k127_4864796_5 Domain present in carbohydrate binding proteins and sugar hydrolses K07218 - - 0.000000000000000001755 99.0
WH2_k127_4864796_6 TIGRFAM transposase, IS605 OrfB family K07496 - - 0.000000000433 63.0
WH2_k127_4954570_0 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000875 168.0
WH2_k127_4954570_1 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000006854 138.0
WH2_k127_4966859_0 Phospholipid methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 334.0
WH2_k127_4966859_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000002531 271.0
WH2_k127_4966859_2 - K19200 - - 0.000000000000000000000000000000000000000003576 158.0
WH2_k127_4966859_3 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000000007929 92.0
WH2_k127_4966859_4 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.000000000000000003844 84.0
WH2_k127_4966859_5 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.00000000009005 66.0
WH2_k127_4997871_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 571.0
WH2_k127_4997871_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 554.0
WH2_k127_4997871_2 AAA domain K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 287.0
WH2_k127_4997871_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha- epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl- CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.000000000000000000000000000000000000000000000000000000000000000000007961 239.0
WH2_k127_5035569_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 341.0
WH2_k127_5035569_1 Transposase, is605 orfb family K07496 - - 0.0000000000000000000000000000000000000000000000000000009172 198.0
WH2_k127_5035569_2 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000004301 166.0
WH2_k127_5035569_3 PFAM ribosomal protein S8E K02995 - - 0.000000000000000000000000000000000000002267 149.0
WH2_k127_5035569_4 Domain of unknown function (DUF1922) - - - 0.0000005713 53.0
WH2_k127_5035948_0 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 519.0
WH2_k127_5035948_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K00187 - 1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008887 384.0
WH2_k127_5035948_2 4Fe-4S dicluster domain K00188 - 1.2.7.7 0.0000000000000000000000000000000003457 133.0
WH2_k127_5055668_0 acid binding OB-fold tRNA helicase-type K07463 - - 1.019e-273 861.0
WH2_k127_5055668_1 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000001753 239.0
WH2_k127_5055668_2 Tetratricopeptide repeat - - - 0.000000000000000000001327 109.0
WH2_k127_5091171_0 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 1.093e-251 794.0
WH2_k127_5091171_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 3.905e-248 782.0
WH2_k127_5091171_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 6.941e-236 747.0
WH2_k127_5091171_3 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 322.0
WH2_k127_5091171_4 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000000000000023 226.0
WH2_k127_5118550_0 SNF2 Helicase protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001821 269.0
WH2_k127_5118550_1 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000333 215.0
WH2_k127_5132752_0 Domain of unknown function DUF123 - - - 0.0000000000000000000000000000003682 128.0
WH2_k127_5141296_0 PFAM N-6 DNA methylase K03427 - 2.1.1.72 1.578e-235 739.0
WH2_k127_5141296_1 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 352.0
WH2_k127_5141296_2 Type I restriction modification DNA specificity domain K01154 - 3.1.21.3 0.0000000000000000000000000000000000000000000000009929 191.0
WH2_k127_5141296_3 Type I restriction modification DNA specificity domain K01154 - 3.1.21.3 0.00000000000000000000000000000000002472 151.0
WH2_k127_5141296_4 ATP-dependent endonuclease K07459 - - 0.00000000000000000000005722 106.0
WH2_k127_5141296_5 radical SAM domain protein - - - 0.000000000005411 72.0
WH2_k127_5142377_0 DEAD DEAH box helicase domain protein K10896 - - 4.787e-227 727.0
WH2_k127_5142377_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 574.0
WH2_k127_5142377_10 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000001124 77.0
WH2_k127_5142377_11 Mo-molybdopterin cofactor metabolic process K03753 - - 0.000000001897 60.0
WH2_k127_5142377_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 368.0
WH2_k127_5142377_3 PFAM GTP-binding protein HSR1-related K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 315.0
WH2_k127_5142377_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009509 287.0
WH2_k127_5142377_5 regulation of canonical Wnt signaling pathway involved in osteoblast differentiation - - - 0.0000000000000000000000000000000000008356 145.0
WH2_k127_5142377_6 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.000000000000000000000000000000000001504 141.0
WH2_k127_5142377_7 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.000000000000000000000000002128 119.0
WH2_k127_5142377_8 Zn-ribbon containing protein K07163 - - 0.00000000000000000000000002718 112.0
WH2_k127_5142377_9 - K00960 - 2.7.7.6 0.0000000000000005485 78.0
WH2_k127_5161808_0 Glycosyltransferase 28 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 407.0
WH2_k127_5161808_1 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000001897 217.0
WH2_k127_5161808_2 PFAM peptidase - - - 0.0000000000000000000000000000000004146 139.0
WH2_k127_5169471_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 2.836e-201 634.0
WH2_k127_5169471_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 532.0
WH2_k127_5169471_10 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000001251 53.0
WH2_k127_5169471_11 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.00002046 53.0
WH2_k127_5169471_2 nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 394.0
WH2_k127_5169471_3 Involved in cell shape control K22222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 399.0
WH2_k127_5169471_4 Domain of unknown function (DUF373) K08975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 317.0
WH2_k127_5169471_5 PFAM glutamate synthase alpha subunit K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000003024 237.0
WH2_k127_5169471_6 - - - - 0.00000000000002052 85.0
WH2_k127_5169471_7 ChaB K06197 - - 0.0000000000006524 72.0
WH2_k127_5169471_8 CARDB - - - 0.000000000001689 77.0
WH2_k127_5169471_9 pilus organization - - - 0.000000000003264 72.0
WH2_k127_5170955_0 Type III restriction enzyme, res subunit K01156 - 3.1.21.5 1.398e-315 991.0
WH2_k127_5170955_1 Tetratricopeptide TPR_2 repeat protein K07503 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005593 263.0
WH2_k127_5170955_2 TPR Domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000002355 225.0
WH2_k127_5173661_0 DJ-1/PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000004782 138.0
WH2_k127_5173661_1 Glycosyl hydrolases family 2, TIM barrel domain - - - 0.000000001053 61.0
WH2_k127_5173661_2 Rubredoxin - - - 0.00000001554 66.0
WH2_k127_5173661_3 COG1522 Transcriptional regulators - - - 0.0000002959 56.0
WH2_k127_5180332_0 FMN binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000732 276.0
WH2_k127_5180332_1 PFAM ABC transporter K00400 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008388 276.0
WH2_k127_5180332_2 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000105 232.0
WH2_k127_5189888_0 nucleoside recognition domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000004285 242.0
WH2_k127_5189888_1 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000005101 235.0
WH2_k127_5189888_2 - K02016 - - 0.00000000000000000000009878 102.0
WH2_k127_5189888_3 Periplasmic binding protein K02016 - - 0.00004342 47.0
WH2_k127_5276030_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 2.018e-278 881.0
WH2_k127_5276030_1 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000008757 182.0
WH2_k127_5276030_2 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000002653 168.0
WH2_k127_5338695_0 Belongs to the MCM family K10726 - - 3.122e-257 811.0
WH2_k127_5338695_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 496.0
WH2_k127_5338695_2 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009911 386.0
WH2_k127_5338695_3 pfam nmd3 K07562 - - 0.00000000000000000000000000000000000000000000000005892 191.0
WH2_k127_5338695_4 hydrolase K04794 - 3.1.1.29 0.000000000000000000000000000000000004593 141.0
WH2_k127_5338695_5 Clp protease K07403 - - 0.00000000000000000000000002652 113.0
WH2_k127_5338695_6 PemK-like, MazF-like toxin of type II toxin-antitoxin system - - - 0.0000000000000000000000005813 108.0
WH2_k127_5338695_7 Protein of unknown function (DUF424) K09148 - - 0.000000000002279 72.0
WH2_k127_5338695_8 Domain of unknown function (DUF1743) - - - 0.000003363 50.0
WH2_k127_5338695_9 NB-ARC domain - - - 0.0002392 47.0
WH2_k127_5397576_0 Translation initiation factor 2 alpha subunit K03237 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 310.0
WH2_k127_5397576_1 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006037 300.0
WH2_k127_5397576_2 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000004653 177.0
WH2_k127_5397576_3 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000001879 142.0
WH2_k127_5397576_4 PFAM Ribosomal protein S27E K02978 - - 0.0000000000000000003118 89.0
WH2_k127_5397576_5 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000005648 77.0
WH2_k127_5408705_0 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000279 208.0
WH2_k127_5408705_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0002654 51.0
WH2_k127_5417272_0 Uncharacterized protein conserved in archaea (DUF2193) - - - 4.07e-258 803.0
WH2_k127_5417272_1 TIGRFAM MIP family channel K02440,K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 364.0
WH2_k127_5417272_2 Uncharacterized protein conserved in archaea (DUF2180) - - - 0.00000000000000000000000000000007049 125.0
WH2_k127_5447143_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 3.965e-200 632.0
WH2_k127_5447143_1 cytochrome c biogenesis protein K06196 - - 0.00000002568 66.0
WH2_k127_5447143_2 Winged helix-turn-helix domain (DUF2582) - - - 0.000001128 54.0
WH2_k127_5505206_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 2e-323 1002.0
WH2_k127_5505206_1 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 370.0
WH2_k127_556036_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 316.0
WH2_k127_556036_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000179 274.0
WH2_k127_556036_2 Ribbon-helix-helix protein, copG family - - - 0.0000000000000000000000000000000000000000000000000000003149 199.0
WH2_k127_556036_3 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000001224 162.0
WH2_k127_556036_4 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000000001125 91.0
WH2_k127_556036_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000001418 89.0
WH2_k127_5622184_0 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004789 423.0
WH2_k127_5622184_1 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002043 253.0
WH2_k127_5622184_2 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000374 110.0
WH2_k127_5622184_3 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000000008475 96.0
WH2_k127_5641130_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 550.0
WH2_k127_5641130_1 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004377 452.0
WH2_k127_5641130_10 extracellular matrix structural constituent - - - 0.0000000001881 75.0
WH2_k127_5641130_11 Copper amine oxidase N-terminal domain K13730,K13731 - - 0.0000000008216 73.0
WH2_k127_5641130_2 von Willebrand factor type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 354.0
WH2_k127_5641130_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 355.0
WH2_k127_5641130_4 DHH family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000829 288.0
WH2_k127_5641130_5 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000186 205.0
WH2_k127_5641130_6 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000001877 196.0
WH2_k127_5641130_7 - - - - 0.00000000000000000000000000000000006157 138.0
WH2_k127_5641130_8 low-complexity proteins - - - 0.0000000000000000002662 98.0
WH2_k127_5641130_9 S-layer homology domain - - - 0.00000000003979 78.0
WH2_k127_5645733_0 COG3547 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004613 274.0
WH2_k127_5645733_1 tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000001195 171.0
WH2_k127_5645733_2 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000000000000002151 152.0
WH2_k127_5645733_3 solute binding protein K02035 - - 0.00000000000000000007131 102.0
WH2_k127_5645733_4 - - - - 0.0000000007844 62.0
WH2_k127_5645733_5 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.0001879 47.0
WH2_k127_5672314_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001479 260.0
WH2_k127_5672314_1 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000005064 250.0
WH2_k127_5672314_2 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000007522 234.0
WH2_k127_5686959_0 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003171 284.0
WH2_k127_5686959_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000001368 62.0
WH2_k127_5730466_0 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007825 300.0
WH2_k127_5730466_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000002993 203.0
WH2_k127_5730466_2 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.00000000000000000000000000000000000000000006992 162.0
WH2_k127_5736064_0 Glycosyltransferase Family 4 K00743 - 2.4.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 352.0
WH2_k127_5736064_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005666 251.0
WH2_k127_5736064_2 RHS Repeat - - - 0.00000000001284 79.0
WH2_k127_5814990_0 Required for chromosome condensation and partitioning K03529 - - 1.829e-283 908.0
WH2_k127_5814990_1 PFAM Radical SAM domain protein K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 565.0
WH2_k127_5814990_2 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 501.0
WH2_k127_5814990_3 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.0000000000000000000000000000000000001678 145.0
WH2_k127_5878255_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 509.0
WH2_k127_5878255_1 PFAM Cation K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 435.0
WH2_k127_5878255_2 cellular potassium ion transport K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009779 355.0
WH2_k127_5878255_3 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 314.0
WH2_k127_5878255_4 Glycogen debranching enzyme N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001304 267.0
WH2_k127_5902590_0 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 556.0
WH2_k127_5902590_1 NnrU protein K21310 - 2.1.1.334 0.000000000000000000000000000000000000000000000000000000004962 206.0
WH2_k127_5902590_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000001155 201.0
WH2_k127_5902590_3 Nitroreductase - - - 0.000000000000001426 78.0
WH2_k127_5985909_0 Isocitrate/isopropylmalate dehydrogenase K00030,K00052 - 1.1.1.41,1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 580.0
WH2_k127_5985909_1 Rio2, N-terminal K07179 - 2.7.11.1 0.000000000000000000000000000000000000004269 151.0
WH2_k127_6025533_0 Flavin containing amine oxidoreductase - - - 1.995e-211 664.0
WH2_k127_6025533_1 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 463.0
WH2_k127_6025533_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000002693 126.0
WH2_k127_6025533_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000001355 113.0
WH2_k127_6027426_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 411.0
WH2_k127_6027426_1 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 358.0
WH2_k127_6027426_10 Domain of unknown function (DUF1805) - - - 0.00000000000000000000007344 101.0
WH2_k127_6027426_11 Domain of unknown function (DUF3786) - - - 0.0000000000002496 78.0
WH2_k127_6027426_2 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008725 359.0
WH2_k127_6027426_3 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 325.0
WH2_k127_6027426_4 Superoxide dismutase K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 295.0
WH2_k127_6027426_5 Transporter Family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003899 250.0
WH2_k127_6027426_6 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000001449 202.0
WH2_k127_6027426_7 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000006578 165.0
WH2_k127_6027426_8 Permease - - - 0.0000000000000000000000000000000000000001421 164.0
WH2_k127_6027426_9 Ferric uptake regulator, Fur family K03711,K09825 GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2000374,GO:2001141 - 0.000000000000000000000000002647 117.0
WH2_k127_6089775_0 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000622 264.0
WH2_k127_6089775_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000008014 228.0
WH2_k127_6089775_2 extracellular matrix structural constituent - - - 0.0000000000000000000000000009005 124.0
WH2_k127_6089775_3 Mut7-C RNAse domain - - - 0.00001304 49.0
WH2_k127_6107951_0 PFAM ribonuclease II K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 324.0
WH2_k127_6107951_1 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000000000000000003584 145.0
WH2_k127_6107951_2 Eco57I restriction-modification methylase - - - 0.00000000000000000000000000000001718 132.0
WH2_k127_6114330_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 8.609e-226 717.0
WH2_k127_6204328_0 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 424.0
WH2_k127_6236451_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1160.0
WH2_k127_6236451_1 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000014 237.0
WH2_k127_6236451_2 Isochorismatase family K08281 - 3.5.1.19 0.00000000000000000000000000000000001099 143.0
WH2_k127_6236451_3 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042802,GO:0046677,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.11.1.15 0.000000000000000003056 86.0
WH2_k127_6236451_4 addiction module toxin, RelE StbE family - - - 0.00000008941 58.0
WH2_k127_6246567_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K22167 - 1.5.98.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 621.0
WH2_k127_6246567_1 Proton-conducting membrane transporter K22168 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 490.0
WH2_k127_6246567_10 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K22166 - 1.5.98.3 0.0000000000000000000000000000000002047 136.0
WH2_k127_6246567_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000005433 117.0
WH2_k127_6246567_12 4Fe-4S dicluster domain K22164 - 1.5.98.3 0.000000000000000000000002351 109.0
WH2_k127_6246567_13 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339,K05578 - 1.6.5.3 0.00000000000005771 79.0
WH2_k127_6246567_14 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.0000002055 54.0
WH2_k127_6246567_15 Predicted nucleotidyltransferase K07074 - - 0.0000005509 60.0
WH2_k127_6246567_2 Proton-conducting membrane transporter K22169 - 1.5.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 441.0
WH2_k127_6246567_3 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 425.0
WH2_k127_6246567_4 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K22161 - 1.5.98.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 435.0
WH2_k127_6246567_5 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 346.0
WH2_k127_6246567_6 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 340.0
WH2_k127_6246567_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 315.0
WH2_k127_6246567_8 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000001548 243.0
WH2_k127_6246567_9 NADH ubiquinone oxidoreductase, 20 Kd subunit K22159 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000007343 238.0
WH2_k127_6278269_0 Tetratricopeptide repeat - - - 0.00000000000000000000338 106.0
WH2_k127_6278269_1 PFAM KAP family P-loop domain - - - 0.0003508 50.0
WH2_k127_6294273_0 Ferrous iron transport B domain protein K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 554.0
WH2_k127_6294273_2 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.0000000000000002126 88.0
WH2_k127_6304618_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 5.366e-222 703.0
WH2_k127_6304618_1 PFAM CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 609.0
WH2_k127_6304618_10 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000002076 130.0
WH2_k127_6304618_11 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000003571 81.0
WH2_k127_6304618_12 Dodecin K09165 - - 0.0000000005131 65.0
WH2_k127_6304618_13 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000006663 64.0
WH2_k127_6304618_14 PBS lyase HEAT-like repeat - - - 0.000007945 55.0
WH2_k127_6304618_2 PFAM Radical SAM domain protein K07129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 349.0
WH2_k127_6304618_3 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008586 347.0
WH2_k127_6304618_4 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 292.0
WH2_k127_6304618_5 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000006741 242.0
WH2_k127_6304618_6 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000001173 233.0
WH2_k127_6304618_7 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000002109 215.0
WH2_k127_6304618_8 SPTR Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000002856 203.0
WH2_k127_6304618_9 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000000000002105 142.0
WH2_k127_6315120_0 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 465.0
WH2_k127_6315120_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 403.0
WH2_k127_6315120_2 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005396 258.0
WH2_k127_6315120_3 Belongs to the UPF0146 family K09713 - - 0.000000000000000000000007433 106.0
WH2_k127_6315120_4 - - - - 0.000000000002787 71.0
WH2_k127_6323838_0 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009869 424.0
WH2_k127_6323838_1 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000505 203.0
WH2_k127_6323838_2 Permease - - - 0.00000000000000000000000000000000000000000000001074 186.0
WH2_k127_6323838_3 Belongs to the UPF0761 family K07058 - - 0.00000000000000000001244 104.0
WH2_k127_6323838_4 NurA - - - 0.0000000000001737 79.0
WH2_k127_6333340_0 TIGRFAM cation diffusion facilitator family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 386.0
WH2_k127_6333340_1 4 iron, 4 sulfur cluster binding - - - 0.0000000000000000000000000000000000000000000000000000003498 198.0
WH2_k127_6333340_2 PFAM Dinitrogenase iron-molybdenum cofactor - - - 0.00000000000000000000000000000000009286 139.0
WH2_k127_6333340_3 Dinitrogenase iron-molybdenum cofactor - - - 0.00000000000000000000000000004981 121.0
WH2_k127_6393523_0 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 527.0
WH2_k127_6393523_1 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 452.0
WH2_k127_6393523_2 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008337 301.0
WH2_k127_6393523_3 shikimate kinase activity K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 294.0
WH2_k127_6393523_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000434 181.0
WH2_k127_6393523_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000006566 88.0
WH2_k127_6393523_6 chorismate mutase K04093 - 5.4.99.5 0.0000000000000002246 82.0
WH2_k127_6399927_0 PFAM Methyltransferase type - - - 0.0000000000000000000000000000000000000000002531 170.0
WH2_k127_6399927_1 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000003762 136.0
WH2_k127_6399927_2 PFAM band 7 protein - - - 0.0000000000000000005022 89.0
WH2_k127_6461636_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K14392 - - 8.651e-211 663.0
WH2_k127_6461636_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 571.0
WH2_k127_6461636_2 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 549.0
WH2_k127_6461636_3 phosphoserine phosphatase activity K01079,K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 524.0
WH2_k127_6461636_4 Non-histone chromosomal protein MC1 - - - 0.0000000000000000000000000003053 115.0
WH2_k127_6461636_5 Belongs to the UPF0147 family K09721 - - 0.00000000006769 62.0
WH2_k127_6461636_6 SigmaK-factor processing regulatory protein BofA - - - 0.000000009088 59.0
WH2_k127_6498198_0 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 3.81e-222 702.0
WH2_k127_6498198_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 287.0
WH2_k127_6498198_2 PFAM phosphatidate cytidylyltransferase - - - 0.000000000193 70.0
WH2_k127_6558296_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 579.0
WH2_k127_6669086_0 nucleoside recognition domain protein K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 451.0
WH2_k127_6669086_1 nucleoside recognition domain protein K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001183 258.0
WH2_k127_6669086_2 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.000000000000000000000000000000000000005288 149.0
WH2_k127_6669086_3 PFAM FeoA family protein K04758 - - 0.000000000000000002344 87.0
WH2_k127_6669086_4 FeoA K04758 - - 0.000000000000000373 80.0
WH2_k127_6669086_5 - - - - 0.0000000003186 66.0
WH2_k127_6669086_6 - - - - 0.0002943 51.0
WH2_k127_6708704_0 methyltransferase K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 335.0
WH2_k127_6708704_1 Ribosomal protein L11 methyltransferase (PrmA) K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 314.0
WH2_k127_6708704_2 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.000000000000000000000000000000002318 133.0
WH2_k127_6708704_3 toxin-antitoxin pair type II binding - - - 0.00000000000000000000000002365 110.0
WH2_k127_6708704_4 Permease K07089 - - 0.00000000000000000000001711 100.0
WH2_k127_6708704_5 - - - - 0.00001003 51.0
WH2_k127_6739207_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 379.0
WH2_k127_6739207_1 PFAM Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000001782 218.0
WH2_k127_6739207_2 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000007177 161.0
WH2_k127_6739207_3 Bacterial toxin of type II toxin-antitoxin system, YafQ - - - 0.000000000000000000000000000003225 122.0
WH2_k127_6739207_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000435 66.0
WH2_k127_6739207_5 - - - - 0.00000005855 57.0
WH2_k127_6739207_6 Domain of unknown function (DUF4139) - - - 0.0000002008 63.0
WH2_k127_6776305_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 3.61e-214 676.0
WH2_k127_6776305_1 Glycogen synthase - - - 1.021e-198 636.0
WH2_k127_6776305_10 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002083 284.0
WH2_k127_6776305_11 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002547 252.0
WH2_k127_6776305_12 Circadian clock protein KaiC - - - 0.0000000000000000000000000000000000000000000000000000000000000000007729 236.0
WH2_k127_6776305_13 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.0000000000000000000000000000000000000000000000000000001943 200.0
WH2_k127_6776305_14 Biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000009659 200.0
WH2_k127_6776305_15 PFAM ABC-2 type transporter K09690 - - 0.00000000000000000000000000000000000000000000000000008313 190.0
WH2_k127_6776305_16 Tetratricopeptide repeat K12600 - - 0.0000000000000000000000000000000000000001648 160.0
WH2_k127_6776305_17 Prokaryotic homologs of the JAB domain - - - 0.000000000000000000000000000000000000001729 150.0
WH2_k127_6776305_18 Uncharacterized conserved protein (DUF2299) - - - 0.00000000000000000000000000000000316 134.0
WH2_k127_6776305_19 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000009716 121.0
WH2_k127_6776305_2 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004637 501.0
WH2_k127_6776305_20 4Fe-4S dicluster domain K00171 - 1.2.7.1 0.000000000000000000000000009486 111.0
WH2_k127_6776305_21 membrane protein domain - - - 0.000000000000000000000001125 108.0
WH2_k127_6776305_22 competence protein COMEC K02238 - - 0.000000000000000000000002993 107.0
WH2_k127_6776305_23 Ion channel - - - 0.0000000000000000226 95.0
WH2_k127_6776305_24 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000001063 83.0
WH2_k127_6776305_25 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000005818 56.0
WH2_k127_6776305_3 Starch synthase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 462.0
WH2_k127_6776305_4 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 436.0
WH2_k127_6776305_5 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 446.0
WH2_k127_6776305_6 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008991 365.0
WH2_k127_6776305_7 ABC transporter K01990,K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 362.0
WH2_k127_6776305_8 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004152 355.0
WH2_k127_6776305_9 Starch synthase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 324.0
WH2_k127_6818153_0 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000004668 265.0
WH2_k127_6818153_1 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000005074 209.0
WH2_k127_6818153_2 glycerophosphoryl diester phosphodiesterase K01126 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008081,GO:0008889,GO:0009279,GO:0016020,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046872,GO:0071944 3.1.4.46 0.00000000000000002028 88.0
WH2_k127_6819933_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K11131 GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008271 338.0
WH2_k127_6819933_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000004526 189.0
WH2_k127_6819933_2 Integral membrane protein DUF106 - - - 0.00000000000000000000000000000000000000000000000000006536 194.0
WH2_k127_6819933_3 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000001187 162.0
WH2_k127_6827015_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 5.068e-201 637.0
WH2_k127_6827015_1 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 507.0
WH2_k127_6827015_2 DNA polymerase beta domain protein region K09717 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 367.0
WH2_k127_6827015_3 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000461 245.0
WH2_k127_6827015_4 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000377 198.0
WH2_k127_6827015_5 Protein of unknown function DUF89 K09116 - - 0.0000000000000000000000000000000000000009557 159.0
WH2_k127_6827015_6 Helix-turn-helix XRE-family like proteins K03627 - - 0.00000000000000000000000000000000000003791 148.0
WH2_k127_6827015_7 protein (ATP-grasp superfamily) K07159 - - 0.0000000000000000000001597 105.0
WH2_k127_6827015_8 - - - - 0.0000000002872 68.0
WH2_k127_6853329_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 431.0
WH2_k127_6853329_1 DNA polymerase K02347 - - 0.0000000000000000000000000000000000000000000000000008656 187.0
WH2_k127_6853329_2 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.0000000000000000000000000000000000000000000000009479 182.0
WH2_k127_685874_0 PFAM Sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000001814 267.0
WH2_k127_685874_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000000005827 171.0
WH2_k127_685874_2 phosphatidylinositol metabolic process K00728 - 2.4.1.109 0.0000000000000000000000000000000000000003329 167.0
WH2_k127_685874_3 DGC domain - - - 0.000000000000000000000004903 106.0
WH2_k127_685874_4 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.00000000000000000000001933 101.0
WH2_k127_685874_5 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000001532 109.0
WH2_k127_685874_6 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000001608 101.0
WH2_k127_685874_7 Rhodanese Homology Domain K01011 GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016782,GO:0016783,GO:0016784,GO:0031668,GO:0033554,GO:0034641,GO:0042221,GO:0042262,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 2.8.1.1,2.8.1.2 0.00000000000001843 85.0
WH2_k127_685874_8 GtrA family K00721,K00786 - 2.4.1.83 0.00001236 54.0
WH2_k127_6869561_0 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 565.0
WH2_k127_6869561_1 Involved in protein export K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002459 261.0
WH2_k127_6869561_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000004277 218.0
WH2_k127_6869561_3 Protein-export membrane protein SecD K03072 - - 0.0000000000000000000000000000001705 132.0
WH2_k127_6948458_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008408 533.0
WH2_k127_6948458_1 DNA modification repair radical SAM protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003988 304.0
WH2_k127_6948458_2 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002576 245.0
WH2_k127_6948458_3 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000001325 186.0
WH2_k127_6948458_4 Cupin domain - - - 0.000000000000000000000001094 107.0
WH2_k127_6968186_0 Von Willebrand factor K07114 - - 2.287e-213 676.0
WH2_k127_6968186_1 protein involved in tellurite resistance - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 498.0
WH2_k127_6968186_2 - - - - 0.000000000000000000000000000000000257 135.0
WH2_k127_6968186_3 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00007344 45.0
WH2_k127_7056931_0 PFAM AMP-dependent synthetase and ligase K00666 - - 0.0 1007.0
WH2_k127_7056931_1 PFAM ferredoxin-dependent glutamate synthase - - - 7.352e-296 913.0
WH2_k127_7056931_10 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000000000000000001195 110.0
WH2_k127_7056931_11 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000001488 95.0
WH2_k127_7056931_12 Pentapeptide repeats (9 copies) - - - 0.00000000000000001499 95.0
WH2_k127_7056931_13 His Kinase A (phosphoacceptor) domain - - - 0.00001029 52.0
WH2_k127_7056931_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 5.28e-229 719.0
WH2_k127_7056931_3 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 565.0
WH2_k127_7056931_4 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 291.0
WH2_k127_7056931_5 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001001 252.0
WH2_k127_7056931_6 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000523 214.0
WH2_k127_7056931_7 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000006575 203.0
WH2_k127_7056931_8 NYN domain - - - 0.0000000000000000000000000000000000000000000000000001698 193.0
WH2_k127_7056931_9 CRISPR-associated endoribonuclease Cas6 - - - 0.00000000000000000000000000000000000003119 156.0
WH2_k127_7100895_0 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 286.0
WH2_k127_7111495_0 Pyridine nucleotide-disulphide oxidoreductase K07137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 596.0
WH2_k127_7111495_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 600.0
WH2_k127_7111495_10 Nicotinamide-nucleotide adenylyltransferase K00952 - 2.7.7.1 0.000000000000000000000000000000000000000001903 159.0
WH2_k127_7111495_11 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.00000000000000000000000000000004852 140.0
WH2_k127_7111495_12 nucleic acid binding OB-fold tRNA helicase-type - - - 0.00000000000000001622 87.0
WH2_k127_7111495_13 F420H2 dehydrogenase subunit FpoO K22170 - 1.5.98.3 0.000004848 55.0
WH2_k127_7111495_2 PFAM major facilitator superfamily MFS_1 K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 531.0
WH2_k127_7111495_3 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 430.0
WH2_k127_7111495_4 FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008771 295.0
WH2_k127_7111495_5 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001989 271.0
WH2_k127_7111495_6 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007065 259.0
WH2_k127_7111495_7 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004695 261.0
WH2_k127_7111495_8 AAA domain K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007347 256.0
WH2_k127_7111495_9 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000007301 201.0
WH2_k127_7124138_0 CobN/Magnesium Chelatase K02230 - 6.6.1.2 0.0 1366.0
WH2_k127_7124138_1 Carbon-nitrogen hydrolase - - - 3.281e-204 651.0
WH2_k127_7124138_10 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000001887 218.0
WH2_k127_7124138_11 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000246 192.0
WH2_k127_7124138_12 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000003062 182.0
WH2_k127_7124138_13 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.00000000000000000000007825 106.0
WH2_k127_7124138_14 PFAM CobN magnesium chelatase K02230 - 6.6.1.2 0.00000000000000002066 82.0
WH2_k127_7124138_15 FecCD transport family K02015 - - 0.0000000003412 61.0
WH2_k127_7124138_17 - - - - 0.0000006494 56.0
WH2_k127_7124138_2 AAA domain (dynein-related subfamily) K03404,K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007177 605.0
WH2_k127_7124138_3 ABC-type Fe3 -siderophore transport system, permease component K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 416.0
WH2_k127_7124138_4 Adenosylcobinamide amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 402.0
WH2_k127_7124138_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 342.0
WH2_k127_7124138_6 PFAM ABC transporter related K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 301.0
WH2_k127_7124138_7 PFAM Radical SAM K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002439 264.0
WH2_k127_7124138_8 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000001887 226.0
WH2_k127_7124138_9 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000001396 221.0
WH2_k127_7151442_0 extracellular matrix structural constituent - - - 0.00000000000000000000000000000000000000000005994 169.0
WH2_k127_7151442_1 PFAM RDD domain containing protein - - - 0.0000000000000000000000001242 111.0
WH2_k127_7151442_2 Belongs to the GbsR family K22109 - - 0.00000002794 61.0
WH2_k127_7193524_0 RNA binding S1 domain protein K06959 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 598.0
WH2_k127_7193524_1 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009454 510.0
WH2_k127_7193524_2 Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000062 166.0
WH2_k127_7193524_3 Cold shock protein K03704 - - 0.000000000000004975 76.0
WH2_k127_7213174_0 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 297.0
WH2_k127_7213174_1 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000005251 203.0
WH2_k127_7213174_2 Probable transposase K07496 - - 0.000000000000000000000000004289 111.0
WH2_k127_7230013_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 4.295e-290 916.0
WH2_k127_7230013_1 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 413.0
WH2_k127_7230013_2 phosphoserine phosphatase SerB K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 413.0
WH2_k127_7230013_3 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000000000000000000000000000000000000000000001011 214.0
WH2_k127_7230013_4 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000003597 165.0
WH2_k127_7230013_5 Glutaredoxin - - - 0.0000000000000000000000000000000008518 132.0
WH2_k127_7230013_6 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000000006392 99.0
WH2_k127_7230013_7 pfam yhs - - - 0.000000000000000007379 89.0
WH2_k127_7240980_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 2.418e-277 874.0
WH2_k127_7240980_1 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000181 67.0
WH2_k127_7285269_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 297.0
WH2_k127_7285269_1 DNA polymerase Ligase (LigD) - - - 0.000000000000000000000000000000000000000000000000000000000001043 215.0
WH2_k127_7285269_2 integral membrane protein K07027 - - 0.000000000000000000000000000000000000000000000000004671 195.0
WH2_k127_7285269_3 general stress protein B in uncultured methanogenic archaeon (Q0W564) - - - 0.0000000000002546 72.0
WH2_k127_7285269_4 Family of unknown function (DUF5350) - - - 0.0000000000152 66.0
WH2_k127_7285269_5 - - - - 0.00000001854 57.0
WH2_k127_7290397_0 AAA domain (dynein-related subfamily) K03404,K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 612.0
WH2_k127_7290397_1 Domain of unknown function (DUF4277) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 551.0
WH2_k127_7290397_2 ABC-type Fe3 -siderophore transport system, permease component K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 418.0
WH2_k127_7290397_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007952 330.0
WH2_k127_7290397_4 Transport permease protein - - - 0.0000000000000000000000000000000000000000000000000000000004575 210.0
WH2_k127_7290397_5 catalyzes the formation of a number of methylated intermediates from arsenite and SAM producing trimethylarsine K07755 - 2.1.1.137 0.000000000002233 76.0
WH2_k127_7380162_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.761e-287 896.0
WH2_k127_7380162_1 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007308 542.0
WH2_k127_7380162_2 MgtE intracellular N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009474 526.0
WH2_k127_7380162_3 AhpC/TSA family K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000007623 212.0
WH2_k127_7380162_4 helix_turn_helix ASNC type K03718 - - 0.000000000000000000000000000000000000000000000000000001845 196.0
WH2_k127_7463614_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009999 569.0
WH2_k127_7463614_1 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000004451 231.0
WH2_k127_7509474_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 303.0
WH2_k127_7509474_1 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 297.0
WH2_k127_7518864_0 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000003272 214.0
WH2_k127_7518864_1 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000001092 120.0
WH2_k127_7518864_2 Protein of unknown function DUF104 - - - 0.000000000000000462 79.0
WH2_k127_7532914_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.88e-294 923.0
WH2_k127_7532914_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 4.109e-290 901.0
WH2_k127_7532914_2 PFAM Fic DOC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 500.0
WH2_k127_7532914_3 HsdM N-terminal domain K03427 - 2.1.1.72 0.0000000000000000000000009205 108.0
WH2_k127_7532914_4 PFAM Radical SAM - - - 0.00000000000000255 79.0
WH2_k127_7546639_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 321.0
WH2_k127_7546639_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007355 273.0
WH2_k127_7546639_2 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000001176 234.0
WH2_k127_7546639_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.0000000000000000000000000002589 117.0
WH2_k127_7546639_4 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000002973 121.0
WH2_k127_7564904_0 TIGRFAM Na Pi-cotransporter II-related protein K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 409.0
WH2_k127_7564904_1 ATPase, P-type transporting, HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009094 311.0
WH2_k127_7573340_0 GXGXG motif K00202 - 1.2.7.12 0.00000000002854 73.0
WH2_k127_7573340_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000006748 61.0
WH2_k127_7589356_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1139.0
WH2_k127_7589356_1 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 1.164e-223 702.0
WH2_k127_7589356_10 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.000000000000000000000000000000000000000000000000000000000002312 218.0
WH2_k127_7589356_11 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000000000000001016 213.0
WH2_k127_7589356_12 PFAM AMMECR1 domain protein K09141 - - 0.00000000000000000000000000000000000000000000000000000007101 201.0
WH2_k127_7589356_13 - - - - 0.00000000000000000000000000000000000000000000001512 182.0
WH2_k127_7589356_14 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000000007438 172.0
WH2_k127_7589356_15 Na -dependent transporter K03453 - - 0.0000000000000000000000000000000000001164 153.0
WH2_k127_7589356_16 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000001803 144.0
WH2_k127_7589356_17 Stage II sporulation protein M K06384 - - 0.0000000000000000000000000000000233 133.0
WH2_k127_7589356_18 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.0000000000000000000000000001197 119.0
WH2_k127_7589356_19 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000000000000005523 111.0
WH2_k127_7589356_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.501e-195 621.0
WH2_k127_7589356_20 4Fe-4S dicluster domain - - - 0.0000000000000000724 81.0
WH2_k127_7589356_21 Transposase, IS605 OrfB family - - - 0.00000000006164 65.0
WH2_k127_7589356_22 - - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464 - 0.000008844 51.0
WH2_k127_7589356_3 DEAD DEAH box helicase domain protein K05592,K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 527.0
WH2_k127_7589356_4 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 429.0
WH2_k127_7589356_5 Has ATPase and non-specific DNA-binding activities K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002412 426.0
WH2_k127_7589356_6 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 368.0
WH2_k127_7589356_7 Belongs to the RtcB family K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 362.0
WH2_k127_7589356_8 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 363.0
WH2_k127_7589356_9 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004948 252.0
WH2_k127_7589990_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 5.573e-215 696.0
WH2_k127_7589990_1 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009418 374.0
WH2_k127_7589990_2 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000001533 76.0
WH2_k127_7589990_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.000000000001587 71.0
WH2_k127_7607015_0 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007466 606.0
WH2_k127_7607015_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005664 355.0
WH2_k127_7607015_2 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 321.0
WH2_k127_7607015_3 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 309.0
WH2_k127_7607015_4 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000002161 231.0
WH2_k127_7607015_5 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000000001181 117.0
WH2_k127_7607015_6 Belongs to the P(II) protein family K02589 - - 0.000000000000000000000001366 109.0
WH2_k127_7607015_8 PFAM Uncharacterised BCR, COG1649 - - - 0.0003117 55.0
WH2_k127_7621687_0 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 3.282e-211 662.0
WH2_k127_7621687_1 binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000009276 221.0
WH2_k127_7621687_2 Domain of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000002227 216.0
WH2_k127_7621687_3 PFAM helix-turn-helix HxlR type - - - 0.000000000000000000000000000000000000000000000002106 176.0
WH2_k127_7621687_4 MacB-like periplasmic core domain K02004 - - 0.0000000000000000002748 89.0
WH2_k127_7657006_0 P-loop containing region of AAA domain K03546 - - 0.000000000000003268 90.0
WH2_k127_7671512_0 PFAM formate nitrite transporter K21993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 446.0
WH2_k127_7671512_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 401.0
WH2_k127_7671512_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 284.0
WH2_k127_7671512_3 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005543 273.0
WH2_k127_7671512_4 phosphonoacetaldehyde hydrolase activity K01560,K07025 - 3.8.1.2 0.00000000000000000000000000000000000000000000003204 178.0
WH2_k127_7671512_5 Probable transposase K07496 - - 0.00000000001922 65.0
WH2_k127_7685754_0 Peptidase M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 429.0
WH2_k127_7685754_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 394.0
WH2_k127_7685754_2 PFAM Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 339.0
WH2_k127_7685754_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000915 261.0
WH2_k127_7685754_4 Small Multidrug Resistance protein K03297 - - 0.00000000000000000000000000000000000007957 144.0
WH2_k127_7712595_0 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 331.0
WH2_k127_7712595_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009108 294.0
WH2_k127_7712595_2 PFAM sigma-70 region 4 domain protein K09714 - - 0.000000000000000000000000001787 117.0
WH2_k127_7761939_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 624.0
WH2_k127_7897263_0 Putative Fe-S cluster - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001112 247.0
WH2_k127_7897263_1 DsrE/DsrF-like family K07235 - - 0.00000000000000000000000000000000000000000000000001215 182.0
WH2_k127_7897263_2 protein involved in the oxidation of intracellular sulfur K07236 - - 0.000000000000000000000000000000000000000007927 156.0
WH2_k127_7897263_3 DsrH like protein K07237 - - 0.00000000000000000006869 92.0
WH2_k127_7927341_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 404.0
WH2_k127_8009063_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 510.0
WH2_k127_8009063_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001964 276.0
WH2_k127_8009063_2 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000001424 260.0
WH2_k127_8009063_3 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000000000000000005266 233.0
WH2_k127_8009063_4 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000000000000000000000007819 156.0
WH2_k127_8009063_5 Non-histone chromosomal protein MC1 - - - 0.0000000000000000000000000000002356 125.0
WH2_k127_8023450_0 Serine dehydrogenase proteinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004848 354.0
WH2_k127_8023450_1 Transposase, is605 orfb family K07496 - - 0.0000000000000000000000000000001328 130.0
WH2_k127_8023450_2 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.000000000000000000000000007075 114.0
WH2_k127_8023450_3 Transposase, is605 orfb family K07496 - - 0.00001436 49.0
WH2_k127_8023450_4 Domain of unknown function (DUF4430) - - - 0.0001721 50.0
WH2_k127_8030194_0 PFAM Papain family cysteine protease - - - 0.00000000000000000000000000000000000000000000000000000000008797 229.0
WH2_k127_8030194_1 DJ-1/PfpI family K03152 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000002269 190.0
WH2_k127_8030194_2 protein N-acetylglucosaminyltransferase activity K12600 - - 0.000000000000000000000000000000000000000004167 161.0
WH2_k127_8030194_3 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000000000007056 139.0
WH2_k127_8030194_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000007117 123.0
WH2_k127_8032889_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 559.0
WH2_k127_8032889_1 Putative transposase DNA-binding domain - - - 0.0000000002142 63.0
WH2_k127_8061502_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006947 592.0
WH2_k127_8061502_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 343.0
WH2_k127_8061502_2 - - - - 0.000000000000000000000000001001 117.0
WH2_k127_8061502_3 Universal stress protein family - - - 0.00000000000008317 76.0
WH2_k127_807246_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005789 398.0
WH2_k127_807246_1 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006249 295.0
WH2_k127_807246_2 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000004811 154.0
WH2_k127_807246_3 Calcineurin-like phosphoesterase - - - 0.0000000005892 70.0
WH2_k127_8141703_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1509.0
WH2_k127_8141703_1 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003871 340.0
WH2_k127_8141703_10 - - - - 0.0001496 44.0
WH2_k127_8141703_3 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004727 289.0
WH2_k127_8141703_4 Major facilitator superfamily - - - 0.0000000000000000000000000000000000001448 156.0
WH2_k127_8141703_5 Protein of unknown function (DUF3467) - - - 0.0000000000000000000000000000003992 126.0
WH2_k127_8141703_6 Lrp/AsnC ligand binding domain - - - 0.00000000000000000009646 90.0
WH2_k127_8141703_7 Y_Y_Y domain - - - 0.000000000000002246 92.0
WH2_k127_8141703_8 SMART Tetratricopeptide domain protein - - - 0.000000000002126 73.0
WH2_k127_8141703_9 metallopeptidase activity K01126,K01181 - 3.1.4.46,3.2.1.8 0.00009328 57.0
WH2_k127_8142421_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 397.0
WH2_k127_8142421_1 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 349.0
WH2_k127_8142421_10 PFAM Peptidase S1 S6, chymotrypsin Hap K04775 - - 0.00000001577 66.0
WH2_k127_8142421_2 PFAM ABC transporter related K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 326.0
WH2_k127_8142421_3 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 308.0
WH2_k127_8142421_4 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 300.0
WH2_k127_8142421_5 Belongs to the UPF0285 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002148 267.0
WH2_k127_8142421_6 ZPR1-related zinc finger protein K06874 - - 0.000000000000000000000000000000000000000000000000002498 188.0
WH2_k127_8142421_7 Belongs to the UPF0179 family K09730 - - 0.000000000000000000000000000000000000000001652 160.0
WH2_k127_8142421_8 ErfK ybiS ycfS ynhG family protein - - - 0.000000000000000000000000000000000006354 151.0
WH2_k127_8142421_9 Pfam:DUF552 K09152 - - 0.000000000000000000000000001969 115.0
WH2_k127_8173153_0 Tetratricopeptide repeat K12600 - - 0.0000000000000000000000000000000000000000000000000000000003133 221.0
WH2_k127_8216368_0 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 496.0
WH2_k127_8216368_1 Glycosyl transferase family group 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 452.0
WH2_k127_8216368_10 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000009318 268.0
WH2_k127_8216368_11 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000002709 215.0
WH2_k127_8216368_12 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000009602 176.0
WH2_k127_8216368_13 ABC-2 type transporter K09690 - - 0.00000000000000000000000000000000000000001543 154.0
WH2_k127_8216368_14 synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000001711 115.0
WH2_k127_8216368_15 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000007365 81.0
WH2_k127_8216368_16 - - - - 0.0000000002147 66.0
WH2_k127_8216368_2 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 453.0
WH2_k127_8216368_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 450.0
WH2_k127_8216368_4 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 411.0
WH2_k127_8216368_5 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 381.0
WH2_k127_8216368_6 NAD-dependent epimerase dehydratase K01784,K03274 - 5.1.3.2,5.1.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 306.0
WH2_k127_8216368_7 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 304.0
WH2_k127_8216368_8 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002559 277.0
WH2_k127_8216368_9 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002384 265.0
WH2_k127_8246154_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 4.695e-272 856.0
WH2_k127_8246154_1 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 380.0
WH2_k127_8246154_2 PFAM PP-loop domain protein - - - 0.000000000000000000000000000000000004879 147.0
WH2_k127_8246154_3 PFAM Methyl-coenzyme M reductase, beta subunit K00401 - 2.8.4.1 0.0001746 44.0
WH2_k127_8247980_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 532.0
WH2_k127_8247980_1 PFAM CBS domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000389 463.0
WH2_k127_8247980_2 Radical SAM superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 407.0
WH2_k127_8247980_3 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000411 261.0
WH2_k127_8247980_4 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.00000000000000000000000000000000000000000000000445 179.0
WH2_k127_8247980_5 Protein of unknown function (DUF357) K09728 - - 0.0000000000000000002123 91.0
WH2_k127_8247980_6 - - - - 0.000000000002068 74.0
WH2_k127_830445_0 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000689 435.0
WH2_k127_830445_1 Protein of unknown function (DUF1614) - - - 0.0000000639 57.0
WH2_k127_8313690_0 Protein of unknown function (DUF460) K09150 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 413.0
WH2_k127_8313690_1 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000000000000000000000000000006341 152.0
WH2_k127_8315195_0 helicase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 581.0
WH2_k127_8315195_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 498.0
WH2_k127_8315195_2 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005075 282.0
WH2_k127_8315195_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000003215 220.0
WH2_k127_8315195_4 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000000000002 100.0
WH2_k127_8324400_0 Segregation and condensation complex subunit ScpB K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000181 240.0
WH2_k127_8324400_1 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000002164 162.0
WH2_k127_8324400_2 Domain of unknown function (DUF4258) - - - 0.0000000000000000000000000000000000000000222 154.0
WH2_k127_8324400_3 Segregation and condensation protein ScpA K05896 - - 0.00000000000000000000000000000000000202 146.0
WH2_k127_8324400_4 - - - - 0.00000000000000000000000000000006349 127.0
WH2_k127_8324400_5 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000000003659 107.0
WH2_k127_8324400_6 mRNA binding - - - 0.000000000000000009535 85.0
WH2_k127_8324400_7 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000121 83.0
WH2_k127_8324400_8 - - - - 0.00000000000034 73.0
WH2_k127_8324400_9 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000002129 67.0
WH2_k127_832941_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 1.705e-243 767.0
WH2_k127_832941_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 5.953e-226 713.0
WH2_k127_832941_10 - - - - 0.000745 51.0
WH2_k127_832941_2 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 553.0
WH2_k127_832941_3 protein conserved in archaea K09746 - - 0.000000000000000000000000000000000000000000000000000000000000000005342 235.0
WH2_k127_832941_4 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000271 191.0
WH2_k127_832941_5 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000005131 158.0
WH2_k127_832941_6 Associated with various cellular activities K04748 - - 0.000000000000000000000000000000000000001497 151.0
WH2_k127_832941_7 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000001389 104.0
WH2_k127_832941_8 Belongs to the UPF0434 family - - - 0.00000000000000000000000375 102.0
WH2_k127_832941_9 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000009512 78.0
WH2_k127_8340387_0 Zinc-uptake complex component A periplasmic K02077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006668 458.0
WH2_k127_8340387_1 ABC 3 transport family K02075 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 427.0
WH2_k127_8340387_10 formylmethanofuran dehydrogenase, subunit E - - - 0.00000000000000000000000000000000000000000000000000000003568 200.0
WH2_k127_8340387_11 ABC transporter K11085 - - 0.0000000000000000000000000000000000000006704 151.0
WH2_k127_8340387_12 histidine kinase A domain protein - - - 0.00000000000000000000000000004357 121.0
WH2_k127_8340387_13 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000001995 111.0
WH2_k127_8340387_14 Periplasmic binding protein K02016 - - 0.00000000000000000002355 104.0
WH2_k127_8340387_15 PFAM nucleoside recognition domain protein - - - 0.000000000001083 78.0
WH2_k127_8340387_16 MFS/sugar transport protein - - - 0.000000000002031 69.0
WH2_k127_8340387_17 PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000002229 80.0
WH2_k127_8340387_18 Predicted RNA-binding protein - - - 0.00000000002542 65.0
WH2_k127_8340387_19 Uncharacterised ArCR, COG2043 - - - 0.0009869 44.0
WH2_k127_8340387_2 (ABC) transporter K06147,K06148,K16014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 431.0
WH2_k127_8340387_3 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 391.0
WH2_k127_8340387_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007514 379.0
WH2_k127_8340387_5 ATPases associated with a variety of cellular activities K02074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 357.0
WH2_k127_8340387_6 PFAM binding-protein-dependent transport systems inner membrane component K02034,K15586 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002185 258.0
WH2_k127_8340387_7 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000008539 244.0
WH2_k127_8340387_8 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000001282 235.0
WH2_k127_8340387_9 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000004549 213.0
WH2_k127_8341344_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 307.0
WH2_k127_8341344_1 cheY-homologous receiver domain - - - 0.00000000000000000000000001983 113.0
WH2_k127_8341344_2 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 0.00000003289 55.0
WH2_k127_8371899_0 Uncharacterised conserved protein (DUF2156) K01163 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 361.0
WH2_k127_8371899_1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000000000004122 166.0
WH2_k127_8389906_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 2.845e-199 632.0
WH2_k127_8389906_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000005353 223.0
WH2_k127_8389906_2 TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.000000274 55.0
WH2_k127_8450556_0 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 480.0
WH2_k127_8450556_1 DNA polymerase X family K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 438.0
WH2_k127_8450556_2 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 382.0
WH2_k127_8450556_3 PINc domain ribonuclease K09006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 316.0
WH2_k127_8450556_4 Domain of unknown function DUF128 K21640 - - 0.0000000000000000000000000000000000000000000000000000000000000001447 228.0
WH2_k127_8450556_5 Belongs to the UPF0212 family K09731 - - 0.000000000000000000000000000000000000002346 149.0
WH2_k127_8451004_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 1.794e-257 799.0
WH2_k127_8451004_1 TIGRFAM Drug resistance transporter Bcr CflA subfamily K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 486.0
WH2_k127_8451004_2 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 345.0
WH2_k127_8451004_3 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002676 256.0
WH2_k127_8451004_4 tRNAHis guanylyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000002331 216.0
WH2_k127_8451004_5 Flavodoxin-like fold - - - 0.00000000000000000000000000000000000000000000000000000000001242 212.0
WH2_k127_8451004_6 PFAM PRC-barrel domain - - - 0.00000000000000000000746 94.0
WH2_k127_8451004_7 - - - - 0.00000000009544 70.0
WH2_k127_8451004_8 - - - - 0.000000003118 68.0
WH2_k127_8465323_0 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 316.0
WH2_k127_8465323_1 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000277 106.0
WH2_k127_8469756_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 8.868e-207 654.0
WH2_k127_8469756_1 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 289.0
WH2_k127_8469756_2 Glutamine cyclotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005633 258.0
WH2_k127_8469756_3 NYN domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003976 242.0
WH2_k127_8469756_4 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000005198 211.0
WH2_k127_8469756_5 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000001485 213.0
WH2_k127_8469756_6 Rhomboid family K07059 - - 0.00000000000000000000000000000000000003372 155.0
WH2_k127_8469756_7 Met-10+ like-protein - - - 0.0000000000000000000000000002098 126.0
WH2_k127_8473846_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 507.0
WH2_k127_8473846_1 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009169 453.0
WH2_k127_8473846_10 Protein of unknown function DUF86 - - - 0.0000000000000000000000000000000008615 134.0
WH2_k127_8473846_11 - - - - 0.000000000000000000000000000004438 127.0
WH2_k127_8473846_12 PFAM thioesterase superfamily K02614 - - 0.0000000000000000000000000000136 124.0
WH2_k127_8473846_13 Transcriptional regulator K07108 - - 0.00000000000000000000000000002471 119.0
WH2_k127_8473846_14 Nucleotidyltransferase domain K07075 - - 0.0000000000000000000000000007661 115.0
WH2_k127_8473846_15 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000001844 88.0
WH2_k127_8473846_16 methyltransferase - - - 0.00000000001005 70.0
WH2_k127_8473846_17 ThiF family K21029,K21147 - 2.7.7.80,2.8.1.11 0.000000002175 61.0
WH2_k127_8473846_18 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000007924 55.0
WH2_k127_8473846_19 CHAT domain - - - 0.0001808 48.0
WH2_k127_8473846_2 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 447.0
WH2_k127_8473846_3 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 443.0
WH2_k127_8473846_4 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009588 389.0
WH2_k127_8473846_5 PFAM PP-loop - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 295.0
WH2_k127_8473846_6 TIGR00268 family K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006887 252.0
WH2_k127_8473846_7 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000004289 244.0
WH2_k127_8473846_8 Functions by promoting the formation of the first peptide bond K03263 - - 0.0000000000000000000000000000000000000000000000001227 179.0
WH2_k127_8473846_9 TfuA-like protein - - - 0.00000000000000000000000000000000000002714 151.0
WH2_k127_8487176_0 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 338.0
WH2_k127_8487176_1 COG1226 Kef-type K transport systems K10716 - - 0.00000000000000000000000000000000000000000000000000000003836 204.0
WH2_k127_8515787_0 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 537.0
WH2_k127_8515787_1 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 495.0
WH2_k127_8515787_2 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000001664 144.0
WH2_k127_8515787_3 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000004776 123.0
WH2_k127_8515787_4 Cysteine-rich small domain K08260 - 3.5.1.90 0.0000000000000000000000002455 117.0
WH2_k127_8533421_0 Methyltransferase type 11 K20444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 520.0
WH2_k127_8533421_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 509.0
WH2_k127_8533421_10 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000007707 111.0
WH2_k127_8533421_11 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000001151 65.0
WH2_k127_8533421_12 COG1525 Micrococcal nuclease (thermonuclease) homologs - - - 0.0005953 46.0
WH2_k127_8533421_2 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009833 430.0
WH2_k127_8533421_3 PHP C-terminal domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 413.0
WH2_k127_8533421_4 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 314.0
WH2_k127_8533421_5 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 309.0
WH2_k127_8533421_6 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002181 275.0
WH2_k127_8533421_7 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003827 252.0
WH2_k127_8533421_8 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000004851 240.0
WH2_k127_8533421_9 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02009 - - 0.0000000000000000000000000005279 124.0
WH2_k127_8579153_0 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000004909 224.0
WH2_k127_8579153_1 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.000000000000000000000000000000000000000000000000001586 191.0
WH2_k127_8579153_2 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000005092 116.0
WH2_k127_8579153_3 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.000000000000000000000002587 106.0
WH2_k127_8579153_4 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000002135 81.0
WH2_k127_8579153_5 structural constituent of ribosome K02924 - - 0.00000000000006565 72.0
WH2_k127_8579153_6 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A K02944 - - 0.00000000004359 64.0
WH2_k127_8649314_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005429 520.0
WH2_k127_8649314_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008614 451.0
WH2_k127_8649314_10 Domain of unknown function (DUF4040) K05566 - - 0.00000000000000000000000000000000000000000000001116 179.0
WH2_k127_8649314_11 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000000000000000001513 174.0
WH2_k127_8649314_12 Na+/H+ ion antiporter subunit K05569 - - 0.0000000000000000000000000000000000000000005382 164.0
WH2_k127_8649314_13 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.000000000000000000000000000000000000000004279 158.0
WH2_k127_8649314_14 - - - - 0.00000000000000000000000000000000000000007517 157.0
WH2_k127_8649314_15 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.00000000000000000000000000000000000001778 150.0
WH2_k127_8649314_16 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.000000000000000000000000000000000000104 148.0
WH2_k127_8649314_17 Na+/H+ antiporter subunit K05571 - - 0.000000000000000000000000000000005308 136.0
WH2_k127_8649314_18 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.00000000000000000000005643 100.0
WH2_k127_8649314_19 Domain of unknown function (DUF4040) K05566 - - 0.0000000000000000001415 91.0
WH2_k127_8649314_2 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 455.0
WH2_k127_8649314_3 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 446.0
WH2_k127_8649314_4 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000674 327.0
WH2_k127_8649314_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 301.0
WH2_k127_8649314_6 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000002542 238.0
WH2_k127_8649314_7 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000000000000000000000000000007095 221.0
WH2_k127_8649314_8 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.00000000000000000000000000000000000000000000000000000000000002674 222.0
WH2_k127_8649314_9 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000001714 195.0
WH2_k127_8666507_0 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette K15342 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 454.0
WH2_k127_8666507_1 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette K09951 - - 0.00000000000000000000000002477 110.0
WH2_k127_8666507_2 - - - - 0.00000419 49.0
WH2_k127_8678995_0 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 295.0
WH2_k127_8678995_1 serine threonine protein kinase K07178 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005848 274.0
WH2_k127_8678995_2 KH domain protein K06961 - - 0.0000000000000000000000000000000000000000000000000000000000002702 218.0
WH2_k127_8678995_3 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.0000000000000000000000000000000000000000006535 158.0
WH2_k127_8720128_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 1.984e-276 863.0
WH2_k127_8720128_1 Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008156 632.0
WH2_k127_8720128_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 413.0
WH2_k127_8720128_3 PFAM Pyruvate kinase, alpha beta domain K09126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002709 283.0
WH2_k127_8720128_4 Acetyl xylan esterase (AXE1) K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000001649 235.0
WH2_k127_8720128_5 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000004242 210.0
WH2_k127_8720128_6 Polyketide cyclase dehydrase - - - 0.0000000000000000000000000000000000000000000006771 169.0
WH2_k127_8720128_7 Domain of unknown function (DUF4982) K01190 - 3.2.1.23 0.000000000000000000000000000000001914 153.0
WH2_k127_8720128_8 Bacterial protein of unknown function (DUF937) - - - 0.000000000000001606 84.0
WH2_k127_8720128_9 Glucose / Sorbosone dehydrogenase - - - 0.0000000005778 75.0
WH2_k127_8742982_0 ATPase, P-type transporting, HAD superfamily, subfamily IC K01537 - 3.6.3.8 2.814e-284 900.0
WH2_k127_8742982_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 393.0
WH2_k127_8742982_2 Pfam:DUF137 K09722 - 6.3.2.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 295.0
WH2_k127_8742982_3 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000002659 248.0
WH2_k127_8742982_4 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000457 237.0
WH2_k127_8742982_5 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000001023 232.0
WH2_k127_8742982_6 Papain family cysteine protease - - - 0.000000000000000000000000000000000000000000000000000000001223 202.0
WH2_k127_8742982_7 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000148 184.0
WH2_k127_8742982_8 Chagasin family peptidase inhibitor I42 K14475 - - 0.0000000000000006895 81.0
WH2_k127_8751343_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 3.006e-310 967.0
WH2_k127_8751343_1 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 5.213e-268 843.0
WH2_k127_8751343_10 PFAM regulatory protein, ArsR K07721 - - 0.0000000000000000000001958 98.0
WH2_k127_8751343_11 metallopeptidase activity - - - 0.000000000001337 81.0
WH2_k127_8751343_12 but it may be involved in stabilization of the trimeric complex - - - 0.00000000006374 66.0
WH2_k127_8751343_13 Uncharacterized protein containing a Zn-ribbon (DUF2116) - - - 0.0000000255 57.0
WH2_k127_8751343_14 - - - - 0.000001192 57.0
WH2_k127_8751343_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.293e-238 754.0
WH2_k127_8751343_3 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 482.0
WH2_k127_8751343_4 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 430.0
WH2_k127_8751343_5 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 350.0
WH2_k127_8751343_6 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 321.0
WH2_k127_8751343_7 PFAM GvpD gas vesicle - - - 0.000000000000000000000000000000000000000000000000000000226 211.0
WH2_k127_8751343_8 methyltransferase activity K00577 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000132 188.0
WH2_k127_8751343_9 Belongs to the UPF0107 family K09128 - - 0.00000000000000000000000000000000000000009963 156.0
WH2_k127_8817214_0 PFAM peptidase M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 312.0
WH2_k127_8817214_1 Probable transposase K07496 - - 0.0000000000000000000000000000000000000000000000000002616 198.0
WH2_k127_8817214_2 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000001455 163.0
WH2_k127_8817214_3 Belongs to the 5'(3')-deoxyribonucleotidase family K05967 - - 0.00000000006756 70.0
WH2_k127_8851378_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000002785 245.0
WH2_k127_8851378_1 Formaldehyde-activating enzyme (Fae) K10713 - 4.2.1.147 0.00000000000000000000000000000000000000000000000000000000000000000001392 237.0
WH2_k127_8851378_2 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000003193 88.0
WH2_k127_8851378_3 PKD domain - - - 0.0008004 51.0
WH2_k127_8935900_0 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001522 218.0
WH2_k127_8935900_1 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.000000000000000000000001627 109.0
WH2_k127_8970959_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 3.214e-230 725.0
WH2_k127_8970959_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 348.0
WH2_k127_8970959_2 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000000000000000000000000000000000006789 207.0
WH2_k127_8970959_3 Lycopene cyclase protein - - - 0.000000000000000000000000000000000000000002809 162.0
WH2_k127_8970959_4 Protein of unknown function (DUF1699) - - - 0.0000000000000000000000000000000000000001446 153.0
WH2_k127_8971783_0 Sodium:solute symporter family K03307 - - 0.000000000000000000000000000000000000000000000000001439 200.0
WH2_k127_8971783_1 - - - - 0.000000000000003843 83.0
WH2_k127_8971783_2 Probable transposase K07496 - - 0.0000006155 51.0
WH2_k127_8971783_3 positive regulation of translation, ncRNA-mediated K03666 - - 0.0003006 46.0
WH2_k127_8990388_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 2.149e-234 737.0
WH2_k127_8990388_1 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 510.0
WH2_k127_8990388_10 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000001258 86.0
WH2_k127_8990388_11 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000003127 77.0
WH2_k127_8990388_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K12143,K15831 - - 0.0000000003201 68.0
WH2_k127_8990388_13 B-block binding subunit of TFIIIC - - - 0.0000004601 61.0
WH2_k127_8990388_14 PFAM glutamate synthase alpha subunit - - - 0.0001209 45.0
WH2_k127_8990388_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000201 212.0
WH2_k127_8990388_3 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00000000000000000000000000000000000000000000000001126 191.0
WH2_k127_8990388_4 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000003446 170.0
WH2_k127_8990388_5 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.0000000000000000000000000000000000000000005658 166.0
WH2_k127_8990388_6 4Fe-4S dicluster domain K00124 - - 0.00000000000000000000000000001883 122.0
WH2_k127_8990388_7 tpr repeat - - - 0.0000000000000000000000001643 109.0
WH2_k127_8990388_8 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000001323 93.0
WH2_k127_8990388_9 Domain of unknown function (DUF1610) K07580 - - 0.000000000000000005159 84.0
WH2_k127_9000928_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 8.504e-202 638.0
WH2_k127_9000928_1 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 569.0
WH2_k127_9000928_10 PFAM Thioredoxin K03671 - - 0.0000000000000000000002508 98.0
WH2_k127_9000928_11 binds to the 23S rRNA K02922 - - 0.000000000000000006835 83.0
WH2_k127_9000928_2 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 498.0
WH2_k127_9000928_3 Metallo-beta-lactamase superfamily K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006461 321.0
WH2_k127_9000928_4 SMART Elongator protein 3 MiaB NifB K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 320.0
WH2_k127_9000928_5 racemase activity, acting on amino acids and derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000008953 220.0
WH2_k127_9000928_6 Bacterial transferase hexapeptide K02617 - - 0.00000000000000000000000000000000000000000000000005346 184.0
WH2_k127_9000928_7 RNA-binding protein (contains PUA domain) K07575 - - 0.0000000000000000000000000000000000000002271 156.0
WH2_k127_9000928_8 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000001649 151.0
WH2_k127_9000928_9 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.000000000000000000000003378 112.0
WH2_k127_9044227_0 COG1132 ABC-type multidrug transport system, ATPase and permease components K02068,K06147,K06148,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 459.0
WH2_k127_9048148_0 Lycopene cyclase protein - - - 0.0000000000000000000000000000000000000000000000000000000001084 211.0
WH2_k127_9048148_1 shikimate kinase activity K00891 - 2.7.1.71 0.000002738 50.0
WH2_k127_9052149_0 Histone deacetylase domain K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006018 247.0
WH2_k127_9052149_1 SMART Peptidase A22, presenilin signal peptide - - - 0.0000000000000000000000000000000000000000000000000000000000000000001109 240.0
WH2_k127_9052149_2 CYTH K05873 - 4.6.1.1 0.000000000001839 70.0
WH2_k127_9079147_0 Heat shock 70 kDa protein K04043 - - 4.727e-261 817.0
WH2_k127_9079147_1 Belongs to the TCP-1 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 563.0
WH2_k127_9079147_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 407.0
WH2_k127_9079147_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000807 377.0
WH2_k127_9079147_4 Phosphate uptake regulator - - - 0.000000000000000000000000000000000000000000000000000363 197.0
WH2_k127_9079147_5 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000004954 158.0
WH2_k127_9079147_6 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000001355 147.0
WH2_k127_9079147_7 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.00000000000000000000000002258 115.0
WH2_k127_9079147_8 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567,K10778 - 2.1.1.63 0.000000000000000000009805 97.0
WH2_k127_9079147_9 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000005022 89.0
WH2_k127_908934_0 PFAM Aminotransferase class I and II K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 299.0
WH2_k127_908934_1 Thiamine pyrophosphate enzyme, C-terminal K00187 - 1.2.7.7 0.000000000000000000000000000000000000000000000000000000000000005479 221.0
WH2_k127_908934_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000000009448 146.0
WH2_k127_908934_3 Protein of unknown function (DUF2281) - - - 0.00000000000000009904 81.0
WH2_k127_908934_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.0000000000007525 76.0
WH2_k127_9116123_0 HI0933 family K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000966 417.0
WH2_k127_9116123_1 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 360.0
WH2_k127_9116123_2 repeat-containing protein - - - 0.00000000000000000000001243 107.0
WH2_k127_9116123_3 PFAM Fe-S cluster domain protein K06939 - - 0.000000000000000201 79.0
WH2_k127_9133711_0 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 354.0
WH2_k127_9133711_1 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000006485 201.0
WH2_k127_9133711_2 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000000000005422 188.0
WH2_k127_9214163_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 2.355e-198 638.0
WH2_k127_9214163_1 Cation transporter/ATPase, N-terminus K01531,K01535 - 3.6.3.2,3.6.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 382.0
WH2_k127_9214163_2 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000005609 159.0
WH2_k127_9214163_3 negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment - - - 0.000000000000000000000000000021 123.0
WH2_k127_9214163_4 alkylhydroperoxidase like protein, AhpD family - - - 0.0000000000000000000000000001372 117.0
WH2_k127_9214163_5 Thiamine-binding protein - - - 0.00000000000005881 76.0
WH2_k127_9214163_6 - - - - 0.0000000000004785 76.0
WH2_k127_9214163_7 Nuclease (SNase domain-containing protein) - - - 0.0000000004468 68.0
WH2_k127_9225156_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 483.0
WH2_k127_9249489_0 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 2.89e-218 694.0
WH2_k127_9249489_1 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000005187 82.0
WH2_k127_9249489_3 Psort location - - - 0.000122 53.0
WH2_k127_9274140_0 ABC-type Fe3 -siderophore transport system, permease component K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 416.0
WH2_k127_9274140_1 cobalt chelatase K02190 - 4.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000006241 233.0
WH2_k127_9274140_2 - - - - 0.00000000000006543 78.0
WH2_k127_9274140_3 PFAM periplasmic binding protein K02016 - - 0.0006667 44.0
WH2_k127_9279591_0 PFAM Helicase conserved C-terminal domain - - - 2.829e-203 643.0
WH2_k127_9279591_1 Uncharacterised protein family (UPF0175) - - - 0.00000000000000000000000000000000000000000000000000000000000000000003279 236.0
WH2_k127_9279591_2 nucleic acid-binding protein contains PIN domain - - - 0.0007442 43.0
WH2_k127_9309749_0 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 331.0
WH2_k127_9309749_1 PFAM metallophosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000005862 199.0
WH2_k127_9309749_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000065 190.0
WH2_k127_9310173_0 CoA binding domain - - - 7.577e-266 835.0
WH2_k127_9310173_1 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 4.923e-231 729.0
WH2_k127_9310173_10 Aerotolerance regulator N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007035 333.0
WH2_k127_9310173_11 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000744 286.0
WH2_k127_9310173_12 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002095 265.0
WH2_k127_9310173_13 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000001399 262.0
WH2_k127_9310173_14 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000000005632 248.0
WH2_k127_9310173_15 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000004151 228.0
WH2_k127_9310173_16 ATP-grasp domain K06914 - 6.3.4.24 0.000000000000000000000000000000000000000000000000000000000000002416 231.0
WH2_k127_9310173_17 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.00000000000000000000000000000000000000000000000000000000000008115 223.0
WH2_k127_9310173_18 Putative Fe-S cluster K11260 - - 0.0000000000000000000000000000000000000000000000000000000008101 205.0
WH2_k127_9310173_19 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000008449 204.0
WH2_k127_9310173_2 PFAM chaperonin Cpn60 TCP-1 K22447 - - 1.539e-194 621.0
WH2_k127_9310173_20 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.000000000000000000000000000000000000000000000000000001421 202.0
WH2_k127_9310173_21 PFAM Phosphatidylglycerophosphatase A - - - 0.000000000000000000000000000000000000000000000000000001577 197.0
WH2_k127_9310173_22 PFAM methyltransferase small K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000001541 188.0
WH2_k127_9310173_23 Uncharacterized protein family UPF0016 - - - 0.000000000000000000000000000000000000000000000000002287 188.0
WH2_k127_9310173_24 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000000001532 186.0
WH2_k127_9310173_25 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000001553 184.0
WH2_k127_9310173_26 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000001808 169.0
WH2_k127_9310173_27 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000001281 177.0
WH2_k127_9310173_28 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000003218 157.0
WH2_k127_9310173_29 Papain family cysteine protease - - - 0.000000000000000000000000000000000000003248 159.0
WH2_k127_9310173_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004175 598.0
WH2_k127_9310173_30 Belongs to the UPF0147 family K09721 - - 0.00000000000000000000000000000001499 129.0
WH2_k127_9310173_31 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.0000000000000000000000000000004809 122.0
WH2_k127_9310173_32 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.000000000000000000000000000001096 128.0
WH2_k127_9310173_33 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.00000000000000000000000000003572 130.0
WH2_k127_9310173_34 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000002671 109.0
WH2_k127_9310173_35 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.0000000000000000000000003952 113.0
WH2_k127_9310173_36 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000003241 102.0
WH2_k127_9310173_37 B-block binding subunit of TFIIIC - - - 0.0000000000000000000002344 101.0
WH2_k127_9310173_38 DNA polymerase beta domain protein region K07076 - - 0.000000000000000000004047 99.0
WH2_k127_9310173_39 Protein of unknown function (DUF473) K09135 - - 0.00000000000000000004066 94.0
WH2_k127_9310173_4 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 577.0
WH2_k127_9310173_40 Molydopterin dinucleotide binding domain K00203 - 1.2.7.12 0.0000000000000000004486 91.0
WH2_k127_9310173_41 NifU-like domain - - - 0.000000000000000001075 87.0
WH2_k127_9310173_42 Binds to the 23S rRNA K02896 - - 0.00000000000000001143 85.0
WH2_k127_9310173_43 - - - - 0.0000000000000000972 81.0
WH2_k127_9310173_44 Cold shock protein K03704 - - 0.0000000000001084 72.0
WH2_k127_9310173_45 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.0000000000006749 75.0
WH2_k127_9310173_46 - - - - 0.0000000000309 68.0
WH2_k127_9310173_47 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 0.00000000006371 72.0
WH2_k127_9310173_48 Gar1/Naf1 RNA binding region K07569 - - 0.0000000001038 65.0
WH2_k127_9310173_49 ATP-grasp domain K06914 - 6.3.4.24 0.0000000005149 61.0
WH2_k127_9310173_5 PFAM dihydropteroate synthase, DHPS - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 438.0
WH2_k127_9310173_50 Metallo-beta-lactamase superfamily K02238 - - 0.0000000007497 71.0
WH2_k127_9310173_51 PLD-like domain - - - 0.000000001254 68.0
WH2_k127_9310173_52 - - - - 0.00000004568 64.0
WH2_k127_9310173_6 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004518 442.0
WH2_k127_9310173_7 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 359.0
WH2_k127_9310173_8 TIGRFAM small GTP-binding protein K06943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005413 352.0
WH2_k127_9310173_9 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 341.0
WH2_k127_9336852_0 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001877 277.0
WH2_k127_9336852_1 Lrp/AsnC ligand binding domain - - - 0.000000000006809 69.0
WH2_k127_9394505_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 458.0
WH2_k127_9394505_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000008829 222.0
WH2_k127_9394505_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000113 171.0
WH2_k127_9394505_3 PFAM GHMP kinase K06982 - 2.7.1.169 0.00000000000000000000000000000000000005061 148.0
WH2_k127_9394505_4 PFAM Protein kinase domain - - - 0.0000000000000000000000000000000003149 143.0
WH2_k127_9394505_5 TPR repeat-containing protein - - - 0.0001609 47.0
WH2_k127_9450861_0 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 510.0
WH2_k127_9450861_1 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 434.0
WH2_k127_9450861_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000116 245.0
WH2_k127_9450861_11 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000009795 210.0
WH2_k127_9450861_12 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.000000000000000000000000000000000000000000000002075 181.0
WH2_k127_9450861_13 PFAM thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000007377 165.0
WH2_k127_9450861_14 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000000001028 107.0
WH2_k127_9450861_15 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.0000000000000000007902 87.0
WH2_k127_9450861_16 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000001224 86.0
WH2_k127_9450861_17 - - - - 0.00000000000000005094 83.0
WH2_k127_9450861_2 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 373.0
WH2_k127_9450861_3 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 336.0
WH2_k127_9450861_4 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 319.0
WH2_k127_9450861_5 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 304.0
WH2_k127_9450861_6 phosphoesterase RecJ domain protein K15986 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 303.0
WH2_k127_9450861_7 HTH-type transcriptional regulatory protein K07728 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 291.0
WH2_k127_9450861_8 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001787 284.0
WH2_k127_9450861_9 PFAM Phosphoribulokinase uridine kinase K00855 - 2.7.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009111 280.0
WH2_k127_9478740_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 535.0
WH2_k127_9481024_0 ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues K01648 GO:0000166,GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003878,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006084,GO:0006085,GO:0006101,GO:0006107,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009893,GO:0009987,GO:0012505,GO:0015936,GO:0016020,GO:0016053,GO:0016125,GO:0016126,GO:0016192,GO:0016740,GO:0016746,GO:0016999,GO:0017076,GO:0017144,GO:0018130,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030141,GO:0030554,GO:0031323,GO:0031325,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032940,GO:0032991,GO:0033500,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0034774,GO:0035337,GO:0035383,GO:0035384,GO:0035578,GO:0035639,GO:0036094,GO:0036230,GO:0042119,GO:0042582,GO:0042592,GO:0042593,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046165,GO:0046390,GO:0046394,GO:0046483,GO:0046903,GO:0046912,GO:0046949,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0055086,GO:0060205,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0071944,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:0101002,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901568,GO:1901570,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653,GO:1904813 2.3.3.8 1.11e-228 726.0
WH2_k127_9481024_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 559.0
WH2_k127_9481024_10 - - - - 0.0000000000001589 76.0
WH2_k127_9481024_2 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 511.0
WH2_k127_9481024_3 ATP citrate synthase activity K01648 GO:0003674,GO:0003824,GO:0003878,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006084,GO:0006085,GO:0006091,GO:0006101,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0046912,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0071944,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 425.0
WH2_k127_9481024_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000007523 230.0
WH2_k127_9481024_5 SMART phosphoesterase PHP domain protein - - - 0.0000000000000000000000000000000000000000000000007175 182.0
WH2_k127_9481024_6 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000006775 166.0
WH2_k127_9481024_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000003842 170.0
WH2_k127_9481024_8 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000004157 159.0
WH2_k127_9481024_9 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.00000000000000000000000000001804 120.0
WH2_k127_9517261_0 PFAM Aminotransferase class I and II K05825 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007915 559.0
WH2_k127_9517261_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000003972 184.0
WH2_k127_9517261_2 - - - - 0.000000000000000000000008473 103.0
WH2_k127_9517261_3 Protein conserved in bacteria - - - 0.00001084 52.0
WH2_k127_956823_0 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005262 526.0
WH2_k127_956823_1 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006084 301.0
WH2_k127_956823_2 regulation of canonical Wnt signaling pathway involved in osteoblast differentiation - - - 0.00000000000000000000000000000000000000000002195 180.0
WH2_k127_956823_3 Dodecin K09165 - - 0.0000000000000000000005214 96.0
WH2_k127_9623553_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 434.0
WH2_k127_9623553_1 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 319.0
WH2_k127_9623553_2 - - - - 0.00000000000000001249 89.0
WH2_k127_9623553_3 Lamin Tail Domain - - - 0.000000000005251 79.0
WH2_k127_9623553_4 Transcriptional regulator - - - 0.0000000000168 69.0
WH2_k127_9623553_5 Pkd domain containing protein - - - 0.0000003352 64.0
WH2_k127_9677272_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 1.685e-202 651.0
WH2_k127_9677272_1 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000000001194 192.0
WH2_k127_9677272_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00004626 46.0
WH2_k127_9800465_0 deaminase K01487 - 3.5.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 293.0
WH2_k127_9800465_1 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.000000000000000000000001887 116.0
WH2_k127_9816098_0 trans-aconitate 2-methyltransferase activity K00598,K02169 - 2.1.1.144,2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 299.0
WH2_k127_9816098_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000001567 188.0
WH2_k127_9816098_2 - - - - 0.0000000002328 65.0
WH2_k127_9816098_3 Transposase - - - 0.0004566 43.0
WH2_k127_9829314_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 572.0
WH2_k127_9829314_1 PFAM ABC transporter K00400 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009386 551.0
WH2_k127_9829314_2 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009975 457.0
WH2_k127_9829314_3 methanogenesis marker protein 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 371.0
WH2_k127_9829314_4 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.000000000000000000000000000000000000000000000000006588 184.0
WH2_k127_9829314_5 - - - - 0.00000000000000000000000000000000000000000000000004106 186.0
WH2_k127_9829314_6 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.00000000000000000000000000000000001109 143.0
WH2_k127_9829314_7 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.0000000000000000000000000000000008345 135.0
WH2_k127_9829314_8 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000004303 117.0
WH2_k127_9829314_9 DNA-binding transcription factor activity - - - 0.000000000003819 71.0
WH2_k127_9977576_0 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 4.672e-250 780.0
WH2_k127_9977576_1 mRNA binding K07339 - - 0.000000000000000000004457 93.0
WH2_k127_9977576_2 PFAM DNA polymerase, beta domain protein region K07075 - - 0.00000000000009588 72.0
WH2_k127_9977963_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008483 363.0
WH2_k127_9977963_1 extracellular matrix structural constituent - - - 0.0000000122 66.0
WH2_k127_9977963_2 COG2897 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000288 53.0