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Overview

ID MAG04216
Name WLSH2_bin.46
Sample SMP0110
Taxonomy
Kingdom Archaea
Phylum Thermoplasmatota
Class E2
Order DHVEG-1
Family DHVEG-1
Genus SM1-50
Species
Assembly information
Completeness (%) 58.39
Contamination (%) 1.13
GC content (%) 39.0
N50 (bp) 4,066
Genome size (bp) 906,728

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes908

Gene name Description KEGG GOs EC E-value Score Sequence
WLSH2_k127_10011684_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 3.6.3.54 2.234e-272 861.0
WLSH2_k127_10011684_1 acetyltransferase K03789 - 2.3.1.128 0.0000000000000000002524 93.0
WLSH2_k127_10011684_2 YHS domain - - - 0.0000000000000000005712 86.0
WLSH2_k127_10012936_0 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.00000000000000000000000000000199 126.0
WLSH2_k127_10012936_1 Winged helix-turn-helix - - - 0.0000000000000000000000000005751 115.0
WLSH2_k127_10012936_2 Pfam:DUF1628 - - - 0.000000000000006928 85.0
WLSH2_k127_10051096_0 O-methyltransferase activity - - - 0.00000000000001848 81.0
WLSH2_k127_10051096_1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase - - - 0.00008835 54.0
WLSH2_k127_10051096_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000638 51.0
WLSH2_k127_10051481_0 Hydroxymethylglutaryl-CoA reductase, degradative K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 502.0
WLSH2_k127_10051481_1 Aspartate carbamoyltransferase K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000001131 183.0
WLSH2_k127_10051481_2 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000001745 168.0
WLSH2_k127_10051481_3 Belongs to the UPF0248 family K09715 - - 0.000007298 50.0
WLSH2_k127_10083690_0 Citrate synthase, C-terminal domain K15234 - 4.1.3.34 0.0000000000000000000000000000000000000000000004596 171.0
WLSH2_k127_10083690_2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0006879 45.0
WLSH2_k127_10095275_0 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004421 551.0
WLSH2_k127_10095275_1 RmlD substrate binding domain K01709 - 4.2.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005276 503.0
WLSH2_k127_10095275_2 exporters of the RND superfamily - - - 0.0000000000000000001942 92.0
WLSH2_k127_10123004_0 DEAD DEAH box helicase domain protein K10896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 455.0
WLSH2_k127_10123004_1 Uncharacterised protein family (UPF0147) K09721 - - 0.000000000000000000000468 97.0
WLSH2_k127_10123004_2 PFAM Xylose isomerase domain protein TIM barrel K01151 - 3.1.21.2 0.0000000000000008993 81.0
WLSH2_k127_10126352_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 343.0
WLSH2_k127_10126352_1 Pheromone shutdown protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009647 301.0
WLSH2_k127_10126352_2 - - - - 0.0000000000000000000000000000000000428 143.0
WLSH2_k127_10126352_3 Peptidase family M50 - - - 0.000000000000000000000000003834 120.0
WLSH2_k127_10126352_4 Belongs to the universal ribosomal protein uS2 family K02967 GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000001084 110.0
WLSH2_k127_10142901_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 369.0
WLSH2_k127_10142901_1 Sulfotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005001 277.0
WLSH2_k127_10142901_3 Lrp/AsnC ligand binding domain - - - 0.000000001363 64.0
WLSH2_k127_10146520_0 Glycosyl transferase family group 2 K12990 - - 0.000000000000000000000000000000000000003872 158.0
WLSH2_k127_10146520_1 Glycosyl transferase family group 2 K12990 - - 0.0000000000000000000000000000000001741 138.0
WLSH2_k127_10147359_0 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 312.0
WLSH2_k127_10147359_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 302.0
WLSH2_k127_10147359_2 Pyruvate:ferredoxin oxidoreductase core domain II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000678 254.0
WLSH2_k127_10147359_3 GHMP kinases N terminal domain K06982 - 2.7.1.169 0.0000000000000000000000000000000001025 144.0
WLSH2_k127_1023211_0 ERCC4 domain K10896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001088 269.0
WLSH2_k127_1023211_1 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000001204 224.0
WLSH2_k127_1023211_2 Uncharacterised protein family (UPF0147) K09721 - - 0.0000000000000000000004725 98.0
WLSH2_k127_1023211_3 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.0003797 46.0
WLSH2_k127_10268767_0 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 414.0
WLSH2_k127_10268767_1 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006052 376.0
WLSH2_k127_10268767_2 TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 349.0
WLSH2_k127_10268767_3 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 338.0
WLSH2_k127_10268767_4 dipeptide transport K02035 - - 0.0000000000000000000000000000000000000000000000000000000000002904 215.0
WLSH2_k127_10319718_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000688 602.0
WLSH2_k127_10319718_1 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 345.0
WLSH2_k127_10319718_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 344.0
WLSH2_k127_10319718_3 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.000000000000000000000000000000486 124.0
WLSH2_k127_10393234_0 Ferrous iron transport B domain protein K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 402.0
WLSH2_k127_10393234_1 FeoA K03709 - - 0.000000000000000000000000000000000000000000000000000000000000000000000449 244.0
WLSH2_k127_10456336_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 353.0
WLSH2_k127_10456336_1 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009825 340.0
WLSH2_k127_10456336_2 PFAM LemA - - - 0.00000000000000000000000000000000000000000000000000000000000005432 218.0
WLSH2_k127_10456336_3 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000001498 223.0
WLSH2_k127_10495703_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 368.0
WLSH2_k127_10495703_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.000000002251 59.0
WLSH2_k127_10505095_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 436.0
WLSH2_k127_10505095_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000006918 226.0
WLSH2_k127_10505095_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.0000000000000000000000000000000000000000000001371 175.0
WLSH2_k127_10505095_3 Transposase IS200 like K07491 - - 0.0000000001311 63.0
WLSH2_k127_1052183_0 peptidyl-lysine modification to peptidyl-hypusine K00809 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004337 445.0
WLSH2_k127_1052183_1 PFAM PP-loop domain protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 315.0
WLSH2_k127_1052183_2 secreted hydrolase - - - 0.000000000000002846 88.0
WLSH2_k127_10539870_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 337.0
WLSH2_k127_10539870_1 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005399 275.0
WLSH2_k127_10539870_2 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000005027 135.0
WLSH2_k127_10595734_0 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 436.0
WLSH2_k127_10595734_1 bacterial-type flagellum-dependent cell motility - - - 0.0000817 54.0
WLSH2_k127_10817150_0 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003709 270.0
WLSH2_k127_10817150_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000004408 230.0
WLSH2_k127_1083503_0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 8.362e-239 745.0
WLSH2_k127_1083503_1 PFAM AMP-dependent synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 573.0
WLSH2_k127_1083503_2 ATP-grasp domain K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000001944 186.0
WLSH2_k127_1083503_3 peptidase activity, acting on L-amino acid peptides K01337,K05994,K20276 - 3.4.11.10,3.4.21.50 0.00000000000000000000000001992 121.0
WLSH2_k127_1083503_4 7 transmembrane helices usually fused to an inactive transglutaminase - - - 0.000000001397 69.0
WLSH2_k127_10945417_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 5.898e-312 970.0
WLSH2_k127_10945417_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000007533 230.0
WLSH2_k127_10945417_2 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000001216 217.0
WLSH2_k127_10974128_0 PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 412.0
WLSH2_k127_10974128_1 tRNA-splicing ligase RtcB K14415 GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 285.0
WLSH2_k127_10974128_2 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000006771 169.0
WLSH2_k127_10974128_3 Belongs to the HMG-CoA reductase family K00021,K00054 - 1.1.1.34,1.1.1.88 0.00000000000000000000000000000006293 126.0
WLSH2_k127_10992863_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 1.26e-206 661.0
WLSH2_k127_10992863_1 Anticodon-binding domain of tRNA K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000111 258.0
WLSH2_k127_10994132_0 COG0058 Glucan phosphorylase - - - 2.246e-221 700.0
WLSH2_k127_10994132_1 Glycogen debranching enzyme N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 476.0
WLSH2_k127_10994132_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 360.0
WLSH2_k127_10994132_3 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000001939 230.0
WLSH2_k127_10994132_4 RibD C-terminal domain K14654 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.302 0.000000000000000000000000000000000000000000000000000000008345 205.0
WLSH2_k127_1104101_0 Coenzyme A transferase K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 466.0
WLSH2_k127_1104101_1 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001932 299.0
WLSH2_k127_1104101_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000004333 172.0
WLSH2_k127_11068437_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 346.0
WLSH2_k127_11068437_1 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 309.0
WLSH2_k127_11068437_2 Co Zn Cd efflux system component K16264 - - 0.000000000000000000000000000000000000000000000000000000000000004233 228.0
WLSH2_k127_11068437_3 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA K00584 - 2.1.1.86 0.00000000000000000000000000000000000000000000000154 184.0
WLSH2_k127_11068437_4 methyltransferase activity K00577 - 2.1.1.86 0.000000000000000000000000000000000001905 144.0
WLSH2_k127_11068437_5 Lysine methyltransferase K02493 - 2.1.1.297 0.00000000000000000000000000000004209 133.0
WLSH2_k127_11070849_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 309.0
WLSH2_k127_11070849_1 PFAM Aminopeptidase I zinc metalloprotease (M18) K01267 - 3.4.11.21 0.000000000000000000000000000000000000002176 148.0
WLSH2_k127_11070849_2 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000134 138.0
WLSH2_k127_11070849_3 - K03741 - 1.20.4.1 0.0000000000003896 73.0
WLSH2_k127_11160844_0 NADH ubiquinone oxidoreductase subunit 1 (Chain H) K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 323.0
WLSH2_k127_11160844_1 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.00000000000000000000000000000000000000000000000000003524 201.0
WLSH2_k127_11160844_2 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K00333,K14090 - 1.6.5.3 0.0000000000000000000000000000000000000006388 152.0
WLSH2_k127_11160844_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K05580 - 1.6.5.3 0.000000000000000000007737 96.0
WLSH2_k127_11160844_4 PFAM peptidase M52 hydrogen uptake protein K08315 GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.23.51 0.00000000000000000244 91.0
WLSH2_k127_11209090_0 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000006127 202.0
WLSH2_k127_11209090_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.00000000000000000000000000000000000000000000001283 174.0
WLSH2_k127_11252846_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000002724 227.0
WLSH2_k127_11322835_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic region K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 392.0
WLSH2_k127_11322835_1 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002807 236.0
WLSH2_k127_11322835_2 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000002568 166.0
WLSH2_k127_11322835_3 RHS Repeat - - - 0.000451 53.0
WLSH2_k127_113502_0 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005448 354.0
WLSH2_k127_113502_1 Starch synthase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 317.0
WLSH2_k127_113502_2 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591,K13421 GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 0.00000000000000000000000000000000000000000000000006524 182.0
WLSH2_k127_11393436_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 3.325e-246 772.0
WLSH2_k127_11393436_1 Belongs to the PdaD family K02626 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000005778 246.0
WLSH2_k127_11393436_2 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.00000000000000000000000000000002361 129.0
WLSH2_k127_11393436_3 Bacterial PH domain - - - 0.00001073 57.0
WLSH2_k127_1140226_0 Carbamoyl-phosphate synthetase ammonia chain K01955 - 6.3.5.5 0.0 1581.0
WLSH2_k127_1140226_1 Belongs to the CarA family K01955,K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008151 267.0
WLSH2_k127_11507456_0 Belongs to the CarA family K01955,K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 470.0
WLSH2_k127_11507456_1 HELICc2 K03722,K10844 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 422.0
WLSH2_k127_11511221_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006324 604.0
WLSH2_k127_11511221_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 589.0
WLSH2_k127_11511221_10 Transposase - - - 0.0003146 50.0
WLSH2_k127_11511221_2 PFAM multi antimicrobial extrusion protein MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 489.0
WLSH2_k127_11511221_3 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 477.0
WLSH2_k127_11511221_4 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 428.0
WLSH2_k127_11511221_5 Belongs to the phosphohexose mutase family K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000001299 259.0
WLSH2_k127_11511221_6 Nucleotidyl transferase K00966 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000002268 233.0
WLSH2_k127_11511221_7 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000543 164.0
WLSH2_k127_11511221_8 Domain present in phytochromes and cGMP-specific phosphodiesterases. K08968 - 1.8.4.14 0.00000000000000000000000000000000000000000003407 165.0
WLSH2_k127_11511221_9 - - - - 0.0002009 46.0
WLSH2_k127_11524692_0 aldehyde ferredoxin oxidoreductase activity K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001356 280.0
WLSH2_k127_11524692_1 Sugar isomerase (SIS) K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000953 275.0
WLSH2_k127_11524692_2 PFAM Glycosyl hydrolases family 38 C-terminal domain - - - 0.0001563 52.0
WLSH2_k127_11559942_0 response to abiotic stimulus - - - 0.0000000000000000000001012 104.0
WLSH2_k127_11559942_1 serine-type aminopeptidase activity - - - 0.000000000000006922 82.0
WLSH2_k127_1188463_0 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001251 277.0
WLSH2_k127_1188463_1 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000005302 106.0
WLSH2_k127_1247493_0 Polysaccharide biosynthesis protein CapD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004824 346.0
WLSH2_k127_1247493_1 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000005717 157.0
WLSH2_k127_1247493_2 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000008785 101.0
WLSH2_k127_1307537_0 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000000000000000000000000000000000000000004348 238.0
WLSH2_k127_1307537_1 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001322 203.0
WLSH2_k127_1307537_2 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000002717 188.0
WLSH2_k127_1307537_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000001166 171.0
WLSH2_k127_1307537_4 ribosomal protein S14 K02954 - - 0.000000000000000001918 85.0
WLSH2_k127_1307537_5 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.000003735 52.0
WLSH2_k127_1361584_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 362.0
WLSH2_k127_143334_0 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 408.0
WLSH2_k127_143334_1 tRNA synthetases class I (W and Y) K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000006121 229.0
WLSH2_k127_143334_2 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K07575 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000005194 148.0
WLSH2_k127_143334_3 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.00000000000000000000000000000000001195 138.0
WLSH2_k127_143334_4 Pfam:DUF552 K09152 - - 0.0000000000000000000000004361 108.0
WLSH2_k127_143334_5 snRNP Sm proteins K04796 GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000007024 91.0
WLSH2_k127_143334_6 Binds to the 23S rRNA K02922 - - 0.0000000000002413 72.0
WLSH2_k127_143334_7 PFAM Uncharacterised protein family (UPF0227) K07000 - - 0.000000108 61.0
WLSH2_k127_1440604_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.995e-246 775.0
WLSH2_k127_1440604_1 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000000000000000003094 216.0
WLSH2_k127_1440604_2 GTP-binding protein HSR1-related K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000009481 137.0
WLSH2_k127_1574228_0 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 - 2.7.1.25,2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 353.0
WLSH2_k127_1574228_1 Catalyzes the synthesis of activated sulfate K00390,K00860,K00958,K13811 GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564 1.8.4.10,1.8.4.8,2.7.1.25,2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000267 222.0
WLSH2_k127_1574228_2 - - - - 0.0000000000000000000000000000000000000000000000000004026 192.0
WLSH2_k127_1605021_0 PFAM Conserved carboxylase region K01571,K01960 - 4.1.1.3,6.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 571.0
WLSH2_k127_1860535_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 464.0
WLSH2_k127_1860535_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 312.0
WLSH2_k127_1860535_2 Elongator protein 3, MiaB family, Radical SAM K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 303.0
WLSH2_k127_1860535_3 tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000004536 187.0
WLSH2_k127_1860535_4 COG0608 Single-stranded DNA-specific exonuclease K07463 - - 0.00000000000000001129 87.0
WLSH2_k127_1860535_5 - - - - 0.000002135 52.0
WLSH2_k127_1860535_6 ribosomal small subunit binding - - - 0.0001678 53.0
WLSH2_k127_1885854_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 8.207e-204 642.0
WLSH2_k127_1885854_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003497 251.0
WLSH2_k127_1885854_2 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000000000000000000000001133 133.0
WLSH2_k127_1885854_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000006255 102.0
WLSH2_k127_1885854_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000003222 91.0
WLSH2_k127_1885854_5 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.0000000000003049 72.0
WLSH2_k127_2022465_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 585.0
WLSH2_k127_2022465_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 404.0
WLSH2_k127_2022465_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000001614 263.0
WLSH2_k127_2022465_3 DNA topoisomerase II activity K02469 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000009864 239.0
WLSH2_k127_2022465_4 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000002113 222.0
WLSH2_k127_2022465_5 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000003464 195.0
WLSH2_k127_2022465_6 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018130,GO:0019178,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000003195 188.0
WLSH2_k127_2022465_7 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000001071 175.0
WLSH2_k127_2071105_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1581.0
WLSH2_k127_2071105_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008295 333.0
WLSH2_k127_2071105_2 4Fe-4S single cluster domain K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 320.0
WLSH2_k127_2071105_3 Lipoate-protein ligase K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 287.0
WLSH2_k127_2071105_4 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003626 273.0
WLSH2_k127_2071105_5 PFAM Histone deacetylase K04768 - - 0.0000000000000000000000000000000000000000000001891 175.0
WLSH2_k127_2071105_6 membrane - - - 0.00000000000000000002473 104.0
WLSH2_k127_2071105_7 PFAM response regulator receiver - - - 0.0000000000000000001231 93.0
WLSH2_k127_2071105_8 Histone deacetylase domain K04768 - - 0.00000000001873 69.0
WLSH2_k127_2071105_9 PFAM biotin lipoate A B protein ligase - - - 0.0000000002642 66.0
WLSH2_k127_207676_0 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 4.128e-254 794.0
WLSH2_k127_207676_1 Fumarate hydratase K01677 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004424 328.0
WLSH2_k127_207676_2 Fe-S type, tartrate fumarate subfamily, beta K01678,K03780 - 4.2.1.2,4.2.1.32 0.000000000000000000000000000000000000000000000000000000007969 203.0
WLSH2_k127_207676_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000001684 62.0
WLSH2_k127_207676_4 Proline dehydrogenase transcriptional activator K03719 - - 0.00000001992 66.0
WLSH2_k127_207676_5 COG1522 Transcriptional regulators K03719 - - 0.000007799 57.0
WLSH2_k127_2091524_0 Penicillin amidase K01434 - 3.5.1.11 0.000000003954 62.0
WLSH2_k127_214745_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009021 372.0
WLSH2_k127_214745_1 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000001319 254.0
WLSH2_k127_214745_2 COG1321 Mn-dependent transcriptional regulator K03709 - - 0.000000000000000000000000000000000000006103 150.0
WLSH2_k127_214745_3 FeS cluster assembly scaffold protein NifU K04488 - - 0.0000000000000000000000000004898 117.0
WLSH2_k127_2188149_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002592 282.0
WLSH2_k127_2188149_1 membrane-associated protein domain - - - 0.00000000004171 76.0
WLSH2_k127_2209563_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 312.0
WLSH2_k127_2209563_1 Glycogen recognition site of AMP-activated protein kinase K01442 - 3.5.1.24 0.000000000000000000000000000000000009691 150.0
WLSH2_k127_2209563_2 menaquinone-dependent protoporphyrinogen oxidase activity K00230 - 1.3.5.3 0.0000000001098 68.0
WLSH2_k127_2241023_0 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000245 182.0
WLSH2_k127_2241023_1 UbiA prenyltransferase family K17105 - 2.5.1.42 0.0000000000000001793 90.0
WLSH2_k127_2241023_2 Prenyltransferase UbiA - - - 0.0008015 48.0
WLSH2_k127_2249832_0 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 2.804e-199 627.0
WLSH2_k127_2249832_1 PFAM Carbamoyl-phosphate synthase L chain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 526.0
WLSH2_k127_2249832_2 Enoyl-CoA hydratase/isomerase K13766,K13779 - 4.2.1.18,4.2.1.57 0.000000000000000000000000000000000000000000000000000000000000001993 225.0
WLSH2_k127_2249832_3 Biotin carboxylase C-terminal domain K01968,K13777 - 6.4.1.4,6.4.1.5 0.00000000000002835 79.0
WLSH2_k127_2256533_0 exporters of the RND superfamily - - - 0.000000000000000000000000000000000000000003628 179.0
WLSH2_k127_2262796_0 Imidazolone-5-propionate hydrolase K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 434.0
WLSH2_k127_2262796_1 Glutamate formiminotransferase K00603 - 2.1.2.5 0.00000000000000000000000000000000000000000003933 164.0
WLSH2_k127_2272535_0 SPFH Band 7 PHB domain protein - - - 0.0000000000000000000000000000000000000000000003353 171.0
WLSH2_k127_2375895_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003904 267.0
WLSH2_k127_2375895_1 Propeptide_C25 - - - 0.000001518 60.0
WLSH2_k127_2420866_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002954 253.0
WLSH2_k127_2420866_1 Formiminotransferase-cyclodeaminase K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000001053 228.0
WLSH2_k127_2420866_2 endonuclease III - - - 0.0000000000000000000000000000000000000000000000000000313 196.0
WLSH2_k127_2420866_3 cyclohydrolase K01746 - 4.3.1.4 0.000000000000000000000000000000000000000000000000001324 189.0
WLSH2_k127_2422389_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1170.0
WLSH2_k127_2422389_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 403.0
WLSH2_k127_2422389_2 Participates in transcription termination K02600 - - 0.00000000000000000000000000002257 122.0
WLSH2_k127_2422389_3 Belongs to the eukaryotic ribosomal protein eL30 family K02908 - - 0.000000000000000004408 87.0
WLSH2_k127_254289_0 Archaeal holliday junction resolvase (hjc) - - - 0.000000000000000000000000000000000000000000004552 169.0
WLSH2_k127_254289_1 PFAM CBS domain containing protein - - - 0.000000000000000000000000000392 120.0
WLSH2_k127_254289_2 PFAM CBS domain containing protein - - - 0.0000000000000000000000000005595 123.0
WLSH2_k127_254289_3 - - - - 0.00000000000000000000003937 103.0
WLSH2_k127_254289_4 Winged helix DNA-binding domain (DUF1495) K09745 - - 0.00000000000000000005573 94.0
WLSH2_k127_254289_5 AMP binding - - - 0.00000000000007685 77.0
WLSH2_k127_2560913_0 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000000000000001298 239.0
WLSH2_k127_2560913_1 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.00000000000000000000000000000000000000000000929 168.0
WLSH2_k127_2560913_2 Acyl-CoA synthetase (NDP forming) K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000001936 130.0
WLSH2_k127_2636634_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008124 486.0
WLSH2_k127_2636634_1 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA K04799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 350.0
WLSH2_k127_2636634_2 aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 337.0
WLSH2_k127_2636634_3 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K01142,K10773 GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000004548 234.0
WLSH2_k127_2636634_4 Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA K14568 GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.260 0.00000000000000000000000000000000000000000000000000000000005183 212.0
WLSH2_k127_2636634_5 transcriptional - - - 0.000000000000000000000000009627 112.0
WLSH2_k127_2636634_6 Winged helix DNA-binding domain (DUF1495) K09745 - - 0.000000000000000000002437 97.0
WLSH2_k127_2651089_0 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 297.0
WLSH2_k127_2651089_1 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000001198 216.0
WLSH2_k127_2651089_2 Catalyzes the hydrolysis of Xaa-His dipeptides K01270 - - 0.000000000000000000000000000000000000000000000000007408 187.0
WLSH2_k127_2651089_3 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000002447 160.0
WLSH2_k127_2651089_4 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000001422 70.0
WLSH2_k127_2651089_5 transferase activity, transferring glycosyl groups K20742 - 3.4.14.13 0.0000002088 55.0
WLSH2_k127_2674966_0 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000009174 192.0
WLSH2_k127_2674966_1 PFAM PKD domain containing protein K11751 - 3.1.3.5,3.6.1.45 0.00000000000000000000000000000000000000000000000001021 196.0
WLSH2_k127_2674966_2 serine threonine protein kinase - - - 0.00000000000000000000001815 110.0
WLSH2_k127_2674966_3 MFS_1 like family - - - 0.0003034 46.0
WLSH2_k127_2682183_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 357.0
WLSH2_k127_2834198_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03237 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 295.0
WLSH2_k127_2834198_1 Diphthamide K07561 - 2.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000473 278.0
WLSH2_k127_2834198_2 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004455 256.0
WLSH2_k127_2834198_3 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.000000000000000000000000000000000000000000000000002854 189.0
WLSH2_k127_2834198_4 Binds to the 23S rRNA K02929 - - 0.000000000000000000000000000000000004651 140.0
WLSH2_k127_2834198_5 PFAM Ribosomal protein S27E K02978 - - 0.0000000000000008331 78.0
WLSH2_k127_2834198_6 protein conserved in archaea K09723 - - 0.0000002068 60.0
WLSH2_k127_2842499_0 Aldolase/RraA K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009205 520.0
WLSH2_k127_2842499_1 Domain of unknown function (DUF362) K07138 - - 0.0000000000000000000000000000000000000000000000001995 188.0
WLSH2_k127_2842499_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K05996,K07752 - 3.4.17.18,3.4.17.22 0.00000000000000000000000000000000000000006297 165.0
WLSH2_k127_2988224_0 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.00000000000000000000000000000000000000000000000000000000007267 213.0
WLSH2_k127_2988224_1 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.0000000000000000000000000000000001708 145.0
WLSH2_k127_3020155_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 8.904e-249 787.0
WLSH2_k127_3020155_1 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 360.0
WLSH2_k127_3248385_0 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 500.0
WLSH2_k127_3248385_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000002177 180.0
WLSH2_k127_3248385_2 PFAM Thiolase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000005041 153.0
WLSH2_k127_3248385_3 archaeal coiled-coil protein - - - 0.000000000000000000000000005365 122.0
WLSH2_k127_3296198_0 AIR synthase related protein, C-terminal domain K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 372.0
WLSH2_k127_3296198_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008321 297.0
WLSH2_k127_3296198_2 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001214 274.0
WLSH2_k127_3296198_3 Nitrite and sulphite reductase 4Fe-4S - - - 0.000000000000005704 75.0
WLSH2_k127_3296198_4 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.000000002744 61.0
WLSH2_k127_3315492_0 PFAM Nitroreductase - - - 0.00000000000000000009917 90.0
WLSH2_k127_3315492_1 Outer membrane protein Omp28 - - - 0.0004094 51.0
WLSH2_k127_3327018_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009281 305.0
WLSH2_k127_3327018_1 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000000005741 190.0
WLSH2_k127_3327018_2 - K00390 - 1.8.4.10,1.8.4.8 0.0000000003617 63.0
WLSH2_k127_3542942_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 3.549e-212 672.0
WLSH2_k127_3542942_1 Transketolase K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 287.0
WLSH2_k127_3542942_2 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001156 293.0
WLSH2_k127_3542942_3 Carbon-nitrogen hydrolase K18540 - 3.5.1.100 0.0000000000000000000000000000000000000000000000000000000000002125 222.0
WLSH2_k127_3542942_4 protein conserved in archaea K09746 - - 0.00000000000000000000000000000000000000000317 160.0
WLSH2_k127_3542942_5 - - - - 0.000000000000000007942 88.0
WLSH2_k127_3581757_0 CorA-like Mg2+ transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002366 288.0
WLSH2_k127_3581757_1 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000000000000000000003751 115.0
WLSH2_k127_3581757_2 methyltransferase activity - - - 0.0000000000007321 74.0
WLSH2_k127_3598453_0 Aminopeptidase I zinc metalloprotease (M18) K01267 - 3.4.11.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005511 475.0
WLSH2_k127_3598453_1 mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000000000000000000000002459 207.0
WLSH2_k127_3598453_2 protein conserved in archaea - - - 0.0000000000000000001328 92.0
WLSH2_k127_3598453_3 PKD domain K19668 - 3.2.1.91 0.0000000001201 72.0
WLSH2_k127_3629701_0 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 322.0
WLSH2_k127_3629701_1 6-O-methylguanine DNA methyltransferase, DNA binding domain K05982 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.21.7 0.00000000000000000000000000000000000000000000000000000000000000000000000002885 260.0
WLSH2_k127_3629701_2 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000003805 164.0
WLSH2_k127_3629701_3 4Fe-4S single cluster domain K04070 - 1.97.1.4 0.00004116 48.0
WLSH2_k127_3660220_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 - 0.000000000000000000000000000000000000000000000000000000000000000000000001751 260.0
WLSH2_k127_3660220_1 - - - - 0.0000000000006688 80.0
WLSH2_k127_3660220_2 Domain of unknown function (DUF4430) - - - 0.0000001141 63.0
WLSH2_k127_3731560_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 297.0
WLSH2_k127_3731560_1 Phosphoesterase PA-phosphatase - - - 0.00000000004256 66.0
WLSH2_k127_3731560_2 Right handed beta helix region - - - 0.0000000003988 69.0
WLSH2_k127_3757869_0 PQQ-like domain - - - 0.0000000000000000000000000001949 132.0
WLSH2_k127_3757869_1 Glycogen recognition site of AMP-activated protein kinase K01442 - 3.5.1.24 0.000000000000000000000000004083 124.0
WLSH2_k127_3865399_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 306.0
WLSH2_k127_3865399_1 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000003989 224.0
WLSH2_k127_3865399_2 Carboxypeptidase regulatory-like domain K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000003967 203.0
WLSH2_k127_3865399_3 small multi-drug export - - - 0.0005763 44.0
WLSH2_k127_3875605_0 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 386.0
WLSH2_k127_3875605_1 Removes 5-oxoproline from various penultimate amino acid residues except L-proline K01304 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564 3.4.19.3 0.00000000000000000000000000008738 124.0
WLSH2_k127_3875605_2 PFAM peptidase - - - 0.00000000000000000000008939 112.0
WLSH2_k127_3875605_3 May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process K03413,K07699 - - 0.00000162 55.0
WLSH2_k127_3880945_0 calcium proton exchanger K07300 - - 0.00000000000000000000000000000000000000000000000000000000000004714 225.0
WLSH2_k127_3880945_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000000000002476 177.0
WLSH2_k127_3880945_2 Beta-L-arabinofuranosidase, GH127 K09955 - - 0.000000000001348 67.0
WLSH2_k127_3916837_0 S-acyltransferase activity K00627,K03310,K03578,K12132 - 2.3.1.12,2.7.11.1,3.6.4.13 0.000000000000000000000000000000000000000000000000000000001462 210.0
WLSH2_k127_3916837_1 Belongs to the bacterial solute-binding protein 3 family K02030 - - 0.000000000000000000000000000000000000000000000000000000004645 207.0
WLSH2_k127_3916837_2 amino acid ABC transporter K02029 - - 0.00000000000000000000000000000000000000000000000000000000471 206.0
WLSH2_k127_3916837_3 Predicted SAM-dependent RNA methyltransferase - - - 0.00000000000000000000000000000000392 136.0
WLSH2_k127_3916837_4 ABC transporter K02028 - 3.6.3.21 0.0000000000000002142 79.0
WLSH2_k127_3948688_0 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000001052 180.0
WLSH2_k127_3948688_1 Located on the platform of the 30S subunit K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000001663 170.0
WLSH2_k127_3948688_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000001967 162.0
WLSH2_k127_3948688_3 class II (D K and N) K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 0.00000000000000000000000000000000000000006243 156.0
WLSH2_k127_3986024_0 Anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 1.467e-311 968.0
WLSH2_k127_3986024_1 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000005719 178.0
WLSH2_k127_3986024_2 Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000004918 160.0
WLSH2_k127_4056840_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 587.0
WLSH2_k127_4056840_1 Lrp/AsnC ligand binding domain - - - 0.0000001519 55.0
WLSH2_k127_407584_0 TIGRFAM ribosomal RNA small subunit methyltransferase RsmB K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 364.0
WLSH2_k127_4088513_0 sequence-specific DNA binding K07108 - - 0.000000000000008188 78.0
WLSH2_k127_4088513_1 MacB-like periplasmic core domain K02004 - - 0.0000000001991 64.0
WLSH2_k127_4088513_2 Glycosyl hydrolase family 48 - - - 0.0000003485 62.0
WLSH2_k127_4118650_0 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000008813 155.0
WLSH2_k127_4118650_1 Thioredoxin K03671 - - 0.0000000000000000000000000000000002291 133.0
WLSH2_k127_4118650_2 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000001491 93.0
WLSH2_k127_4157411_0 TatD related DNase K07049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004985 252.0
WLSH2_k127_4157411_1 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.0000000000000000000000000000000000000000000001265 175.0
WLSH2_k127_4157411_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000003884 164.0
WLSH2_k127_4157411_3 Phosphoesterase PA-phosphatase - - - 0.00000000000000003223 91.0
WLSH2_k127_4161727_0 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 434.0
WLSH2_k127_4161727_1 tRNA pseudouridine synthase D K06176 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 0.0000000000000000000000000000000000000000000000000000003296 203.0
WLSH2_k127_4194877_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 3.079e-253 792.0
WLSH2_k127_4194877_1 PFAM Acyl-CoA dehydrogenase K00248,K22430 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108,1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 436.0
WLSH2_k127_4295690_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 365.0
WLSH2_k127_4308748_0 Heterodisulfide reductase subunit A and related polyferredoxins K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002921 552.0
WLSH2_k127_4308748_1 Nickel-dependent hydrogenase K14126 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 411.0
WLSH2_k127_4308748_2 PFAM NADH ubiquinone oxidoreductase, 20 K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000005046 210.0
WLSH2_k127_4317364_0 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000003099 232.0
WLSH2_k127_4317364_1 NAD(P)H-binding K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000001339 225.0
WLSH2_k127_4317364_2 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000001567 81.0
WLSH2_k127_4320214_0 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000002255 196.0
WLSH2_k127_4320214_1 - - - - 0.0002645 47.0
WLSH2_k127_4320214_2 glucose sorbosone - - - 0.000285 48.0
WLSH2_k127_4321946_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 437.0
WLSH2_k127_4321946_1 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 347.0
WLSH2_k127_4321946_2 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000491 277.0
WLSH2_k127_4321946_3 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000003596 192.0
WLSH2_k127_4321946_4 membrane - - - 0.000000000000000000000000007017 122.0
WLSH2_k127_4321946_5 PFAM regulatory protein, ArsR - - - 0.000000000000000433 87.0
WLSH2_k127_4321946_6 Domain of unknown function (DUF1610) K07580 - - 0.000000000000001956 77.0
WLSH2_k127_4321946_7 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.000000001336 62.0
WLSH2_k127_4396854_0 protein conserved in archaea - - - 0.000000000000000000000000000003892 125.0
WLSH2_k127_4431133_0 glutamate-tRNA ligase activity K01886 GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 2.691e-257 804.0
WLSH2_k127_4431133_1 Threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 409.0
WLSH2_k127_4431133_2 Papain family cysteine protease K11751,K14647 - 3.1.3.5,3.6.1.45 0.00000000000000000000000006693 124.0
WLSH2_k127_4431133_3 Domain of unknown function (DUF4870) - - - 0.00000000000000000000004937 101.0
WLSH2_k127_4431133_4 - - - - 0.00000000000000002437 82.0
WLSH2_k127_4431133_5 PFAM PKD domain containing protein - - - 0.00000000000008506 85.0
WLSH2_k127_4431133_6 EamA-like transporter family - - - 0.00000684 57.0
WLSH2_k127_4454984_0 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005227 446.0
WLSH2_k127_4454984_1 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006906 373.0
WLSH2_k127_4454984_2 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.00000000000000000000000000000000000000000000000000000000000000000000000001563 256.0
WLSH2_k127_4454984_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000002702 96.0
WLSH2_k127_4543567_0 Belongs to the peptidase S16 family K06870 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007007 297.0
WLSH2_k127_4543567_1 tRNA intron endonuclease, catalytic C-terminal domain K01170 GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360 4.6.1.16 0.000000000000000000004785 101.0
WLSH2_k127_4605496_0 double-strand break repair K01867,K09946 - 6.1.1.2 0.00000000000000005834 83.0
WLSH2_k127_4605496_1 helix_turn_helix ASNC type K03719 - - 0.0000002472 59.0
WLSH2_k127_4605496_2 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000008511 56.0
WLSH2_k127_4685335_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0002161,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.166e-209 683.0
WLSH2_k127_4685335_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 499.0
WLSH2_k127_4685335_10 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134,K00150 - 1.2.1.12,1.2.1.59 0.000000002068 59.0
WLSH2_k127_4685335_11 Ribosomal protein S1-like RNA-binding domain K07463 - - 0.00000009838 55.0
WLSH2_k127_4685335_12 but it may be involved in stabilization of the trimeric complex - - - 0.0000006355 52.0
WLSH2_k127_4685335_2 tRNA binding K04566 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 485.0
WLSH2_k127_4685335_3 methylthiotransferase activity K15865 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 345.0
WLSH2_k127_4685335_4 Helix-turn-helix XRE-family like proteins K07731 - - 0.00000000000000000000000000000000000000000000000000000000000000000009042 238.0
WLSH2_k127_4685335_5 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000005038 205.0
WLSH2_k127_4685335_6 pyruvate synthase activity K00172,K00189 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000000000000000007074 176.0
WLSH2_k127_4685335_7 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000009483 138.0
WLSH2_k127_4685335_8 oxidoreductase, delta subunit K00171 - 1.2.7.1 0.0000000000000000000000000003515 115.0
WLSH2_k127_4685335_9 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000003739 66.0
WLSH2_k127_4694680_0 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002675 255.0
WLSH2_k127_4782770_0 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 441.0
WLSH2_k127_4782770_2 deoxyhypusine monooxygenase activity - - - 0.000002066 54.0
WLSH2_k127_4821923_0 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 433.0
WLSH2_k127_4821923_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 334.0
WLSH2_k127_4821923_2 Small conductance mechanosensitive ion channel, MscS family K03442,K16052,K22044 - - 0.000000000000000000000000000000000000000000000000000232 199.0
WLSH2_k127_4821923_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000007011 179.0
WLSH2_k127_4821923_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000000000000000000000000000002073 159.0
WLSH2_k127_4821923_5 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000004059 133.0
WLSH2_k127_4821923_6 - - - - 0.000000000000000000000001423 108.0
WLSH2_k127_4821923_7 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000001421 61.0
WLSH2_k127_4826586_0 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006077 299.0
WLSH2_k127_4826586_1 Protein of unknown function (DUF554) K07150 - - 0.00000000005507 66.0
WLSH2_k127_4926568_0 PFAM histone deacetylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000677 243.0
WLSH2_k127_4926568_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000002811 221.0
WLSH2_k127_4926568_2 Thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000002378 136.0
WLSH2_k127_4926568_3 - - - - 0.00000000000001263 77.0
WLSH2_k127_4926568_4 DNA polymerase K02320 - 2.7.7.7 0.00004889 57.0
WLSH2_k127_497841_0 Cleaves the N-terminal amino acid of tripeptides K01270 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006642 477.0
WLSH2_k127_497841_1 radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000003665 232.0
WLSH2_k127_497841_2 transferase activity, transferring glycosyl groups K20742 - 3.4.14.13 0.0000000000000000000000000000000000000000000000000000001069 203.0
WLSH2_k127_4985887_0 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000005133 167.0
WLSH2_k127_4985887_1 PFAM cation transporter K03498 - - 0.00000007254 60.0
WLSH2_k127_4985887_2 COG0170 Dolichol kinase - - - 0.0002007 52.0
WLSH2_k127_5083330_0 Cysteinyl-tRNA synthetase K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 477.0
WLSH2_k127_5083330_1 Belongs to the eukaryotic ribosomal protein eL15 family K02877 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000007272 229.0
WLSH2_k127_5083330_2 DHHA1 domain K07463 - - 0.00000000000000000000000000000000000000000000002822 182.0
WLSH2_k127_5083330_3 structural constituent of ribosome K02956 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000005106 161.0
WLSH2_k127_5083330_4 Belongs to the universal stress protein A family - - - 0.000000000008134 70.0
WLSH2_k127_5083330_5 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000002838 66.0
WLSH2_k127_5113079_0 glutamine synthetase K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 483.0
WLSH2_k127_5113079_1 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000004963 156.0
WLSH2_k127_5154492_0 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K09833 GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009987,GO:0010189,GO:0018130,GO:0042360,GO:0042362,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617 2.5.1.115,2.5.1.116 0.00000001457 65.0
WLSH2_k127_5276969_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K03239,K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000999 375.0
WLSH2_k127_5276969_1 Pfam:KaiC - - - 0.0000000000000000000006059 105.0
WLSH2_k127_5276969_2 PFAM class II aldolase adducin family protein - - - 0.00000002308 63.0
WLSH2_k127_5280927_0 Belongs to the PdaD family K02626 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000002939 247.0
WLSH2_k127_5280927_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.00000004781 54.0
WLSH2_k127_5280927_2 Bacterial PH domain - - - 0.0007853 51.0
WLSH2_k127_5327894_0 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.206 0.000000000000000000000000000000000000000000000000000000003559 203.0
WLSH2_k127_5327894_1 Winged helix DNA-binding domain (DUF1495) K09745 - - 0.000000000000000000008401 96.0
WLSH2_k127_5327894_2 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.000000000007962 67.0
WLSH2_k127_54280_0 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 571.0
WLSH2_k127_54280_1 Biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000005951 199.0
WLSH2_k127_54280_2 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.0000000000000000000000000000003959 129.0
WLSH2_k127_54280_3 conserved protein, contains double-stranded beta-helix domain - - - 0.000000000000000000001319 98.0
WLSH2_k127_54280_4 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.00000000000000003386 84.0
WLSH2_k127_5482599_0 Type II/IV secretion system protein K07332 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 300.0
WLSH2_k127_5482599_1 Type II secretion system (T2SS), protein F K07333 - - 0.00000000000000000000000003896 125.0
WLSH2_k127_5482599_2 Type II secretion system K07333 - - 0.0000000000000000000003193 112.0
WLSH2_k127_5482729_0 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 321.0
WLSH2_k127_5482729_1 Peptidase S9 prolyl oligopeptidase active site K01281 - 3.4.14.11 0.000000000000000000000000000000000000000000000000000000000000000000000000005995 263.0
WLSH2_k127_5482729_2 Gaf domain K02488 - 2.7.7.65 0.000000000000000007384 97.0
WLSH2_k127_5541201_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007199 434.0
WLSH2_k127_5541201_1 GyrI-like small molecule binding domain - - - 0.000000000000000001048 89.0
WLSH2_k127_5541201_2 Protein of unknown function (DUF3795) - - - 0.000000000267 62.0
WLSH2_k127_5541201_3 membrane-associated protein domain - - - 0.000004013 60.0
WLSH2_k127_5553603_0 With S4 and S12 plays an important role in translational accuracy K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 294.0
WLSH2_k127_5553603_1 Ribosomal protein L30p/L7e K02907 GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000001173 176.0
WLSH2_k127_5553603_2 Belongs to the universal ribosomal protein uS2 family K02967 GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000003308 173.0
WLSH2_k127_5553603_3 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000004948 168.0
WLSH2_k127_5553603_4 binds to the 23S rRNA K02885 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000002547 163.0
WLSH2_k127_5553603_5 Belongs to the eukaryotic ribosomal protein eL32 family K02912 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000164 130.0
WLSH2_k127_5553603_6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.000000000000000009446 85.0
WLSH2_k127_5562411_0 Major Facilitator Superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 368.0
WLSH2_k127_5562411_1 Anticodon-binding domain of tRNA K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.000000000000000000000000000000000000000000000001013 186.0
WLSH2_k127_5562411_2 Belongs to the UPF0178 family - - - 0.000000000000000000000000000000000000000000000004119 175.0
WLSH2_k127_5604131_0 PFAM Aminotransferase class I and II K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007718 424.0
WLSH2_k127_5604131_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000003006 230.0
WLSH2_k127_5604131_2 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000427 74.0
WLSH2_k127_5604131_3 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0001924 46.0
WLSH2_k127_5679603_0 DHHA1 domain K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 464.0
WLSH2_k127_5679603_1 Arginase family K01476,K01480 GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.1,3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000116 237.0
WLSH2_k127_5679603_2 Functions by promoting the formation of the first peptide bond K03263 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000175 179.0
WLSH2_k127_5679603_3 Uncharacterised conserved protein (DUF2156) K01163 - - 0.0000000000000000000000000000000000000000000003141 174.0
WLSH2_k127_5679603_4 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000000000001322 166.0
WLSH2_k127_5679603_5 dihydromethanopterin reductase activity K00176,K06411,K12527 - 1.2.7.3,1.97.1.9 0.000000000000001569 78.0
WLSH2_k127_5679603_6 PFAM peptidase U32 K08303 - - 0.00000000001644 67.0
WLSH2_k127_5679603_7 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.000000007702 67.0
WLSH2_k127_5679603_8 Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. - - - 0.0000003456 61.0
WLSH2_k127_5715273_0 Belongs to the PdaD family K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000007605 250.0
WLSH2_k127_5715273_1 Flavodoxin domain - - - 0.000000000000000000000000000000000000000000000000007785 183.0
WLSH2_k127_5715273_2 COG1321 Mn-dependent transcriptional regulator K03709 - - 0.00000000000000000000000000000002203 130.0
WLSH2_k127_5715273_3 PFAM nitrogen-fixing NifU domain protein K04488 - - 0.0000000000000000000000000003848 117.0
WLSH2_k127_5715273_4 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000009525 85.0
WLSH2_k127_5735132_0 arsenite transmembrane transporter activity K03893 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008490,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042960,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000156 288.0
WLSH2_k127_5735132_1 ABC transporter K06158 - - 0.00000000000000000000000000000000000000000000000000000002289 213.0
WLSH2_k127_5767925_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000002409 271.0
WLSH2_k127_5767925_1 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000000001242 192.0
WLSH2_k127_5767925_2 Electron transfer flavoprotein K03522,K22432 - 1.3.1.108 0.000000002025 60.0
WLSH2_k127_5782790_0 PFAM CoA-binding domain protein K01905,K09181,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 409.0
WLSH2_k127_5782790_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000002196 207.0
WLSH2_k127_5782790_2 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000005515 194.0
WLSH2_k127_5782790_3 pfam nmd3 K07562 - - 0.000000000000000000000000000000000000000000001552 178.0
WLSH2_k127_590908_0 NmrA-like family - - - 0.0000000000000000000000000000000000000008878 160.0
WLSH2_k127_590908_1 Protein of unknown function (DUF424) K09148 - - 0.00000000000000000000000006425 109.0
WLSH2_k127_590908_2 Mut7-C RNAse domain K09122 - - 0.0000000000000000003503 91.0
WLSH2_k127_590908_3 Sugar (and other) transporter K08369 - - 0.000000000003245 79.0
WLSH2_k127_590908_4 Sugar (and other) transporter K08369 - - 0.000000003282 69.0
WLSH2_k127_590908_5 metal ion transmembrane transporter activity - - - 0.000000004906 64.0
WLSH2_k127_5912389_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 421.0
WLSH2_k127_5912389_1 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000002746 181.0
WLSH2_k127_5912389_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000008714 149.0
WLSH2_k127_5912389_3 RmlD substrate binding domain - - - 0.0000000000000000161 81.0
WLSH2_k127_5912389_4 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain K07746 - - 0.000001232 54.0
WLSH2_k127_5952152_0 P-type ATPase K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 539.0
WLSH2_k127_5952152_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 412.0
WLSH2_k127_5952152_2 Belongs to the peptidase M24B family K01271 - 3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 346.0
WLSH2_k127_5952152_3 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000000006594 230.0
WLSH2_k127_5952152_4 Transcriptional regulator, TrmB - - - 0.00000000000000000000000008463 111.0
WLSH2_k127_6002104_0 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000006562 134.0
WLSH2_k127_6002104_1 PFAM Peptidase C1A, papain - - - 0.000001938 61.0
WLSH2_k127_6063218_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 398.0
WLSH2_k127_6063218_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 373.0
WLSH2_k127_6063218_2 PFAM Endonuclease Exonuclease phosphatase K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 362.0
WLSH2_k127_6063218_3 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 313.0
WLSH2_k127_6063218_4 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009445 291.0
WLSH2_k127_6063218_5 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000789 262.0
WLSH2_k127_6063218_6 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000009027 255.0
WLSH2_k127_6063218_7 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000001013 218.0
WLSH2_k127_6063218_8 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000707 55.0
WLSH2_k127_6091810_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 8.677e-222 704.0
WLSH2_k127_6091810_1 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000000000000000000000000000000000006052 185.0
WLSH2_k127_6091810_2 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.000000000000000000000000000000000009552 138.0
WLSH2_k127_6091810_3 Belongs to the PDCD5 family K06875 - - 0.00000000000000000003915 93.0
WLSH2_k127_6091810_4 Belongs to the ribosomal protein L31e family K02910 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000008476 91.0
WLSH2_k127_6091810_5 Belongs to the eukaryotic ribosomal protein eL39 family K02924 - - 0.0000000000002763 70.0
WLSH2_k127_6091810_6 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.0000272 47.0
WLSH2_k127_6141173_0 ABC transporter, ATP-binding protein K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000759 269.0
WLSH2_k127_6141173_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001007 263.0
WLSH2_k127_6141173_2 Predicted membrane protein (DUF2318) - - - 0.0000000000000000000000003066 111.0
WLSH2_k127_6141173_3 NifU-like N terminal domain K04488 - - 0.000000000000000004399 89.0
WLSH2_k127_6141173_4 sequence-specific DNA binding K07108 - - 0.0000000000001323 76.0
WLSH2_k127_6141173_5 Peptidase inhibitor I9 K20754 - 3.4.21.111 0.000002579 57.0
WLSH2_k127_6219035_0 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007691 256.0
WLSH2_k127_6219035_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000001253 151.0
WLSH2_k127_6219035_2 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000015 85.0
WLSH2_k127_6219035_3 COG1522 Transcriptional regulators - - - 0.0000006183 58.0
WLSH2_k127_6238422_0 PFAM SOUL heme-binding protein - - - 0.00000000000000000000000000000000000003909 149.0
WLSH2_k127_6238422_1 Nitroreductase family - - - 0.0000000000000000000000000000002934 127.0
WLSH2_k127_6238422_2 PFAM Fatty acid hydroxylase K15746 - 1.14.15.24 0.0000000000008097 73.0
WLSH2_k127_6238422_3 Fatty acid hydroxylase superfamily K15746 - 1.14.15.24 0.00001032 50.0
WLSH2_k127_6334164_0 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 449.0
WLSH2_k127_6334164_1 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003534 275.0
WLSH2_k127_6334164_2 - - - - 0.00000752 52.0
WLSH2_k127_6364741_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 543.0
WLSH2_k127_6364741_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K03918 - 2.6.1.19,2.6.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007036 512.0
WLSH2_k127_6364741_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000008473 226.0
WLSH2_k127_6364741_3 PFAM amidohydrolase - - - 0.0000000000000000000000000003745 121.0
WLSH2_k127_6364741_4 Amidohydrolase family - - - 0.00000000008068 69.0
WLSH2_k127_6440991_0 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000006728 157.0
WLSH2_k127_6440991_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000003846 153.0
WLSH2_k127_6440991_2 Belongs to the eukaryotic ribosomal protein eL18 family K02883 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000001428 145.0
WLSH2_k127_6440991_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000003558 108.0
WLSH2_k127_6440991_4 HYR domain - - - 0.0000000000000000000006344 111.0
WLSH2_k127_6440991_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.0000000000000000003659 90.0
WLSH2_k127_6440991_6 Transcriptional regulator - - - 0.000000000000000006244 93.0
WLSH2_k127_6440991_7 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000001664 68.0
WLSH2_k127_6440991_8 ABC-2 family transporter protein K19341 - - 0.00004129 50.0
WLSH2_k127_6567337_0 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000003969 161.0
WLSH2_k127_6567337_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000001069 154.0
WLSH2_k127_6567337_2 PFAM Fibronectin type III domain - - - 0.000000000000000000000000001699 126.0
WLSH2_k127_6567337_3 PFAM Peptidase C1A, papain - - - 0.0000000000000000000003244 113.0
WLSH2_k127_6567337_4 cellulase activity - - - 0.000000001154 72.0
WLSH2_k127_6567337_5 Esterase PHB depolymerase - - - 0.000002148 60.0
WLSH2_k127_664577_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 446.0
WLSH2_k127_664577_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006846 241.0
WLSH2_k127_664577_2 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000000002156 117.0
WLSH2_k127_664577_3 - - - - 0.00005936 47.0
WLSH2_k127_6648377_0 PFAM PQQ enzyme repeat - - - 0.000000000000000000000000000000000000000000000000000000009833 209.0
WLSH2_k127_6648377_1 Peptidase family M28 - - - 0.00000178 62.0
WLSH2_k127_6789886_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.112e-219 702.0
WLSH2_k127_6789886_1 Asparaginase K01424 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000003773 222.0
WLSH2_k127_6789886_2 PFAM peptidylprolyl isomerase FKBP-type K01802 - 5.2.1.8 0.00000000000000000000006199 104.0
WLSH2_k127_6789886_3 peptidase activity, acting on L-amino acid peptides K01337,K05994,K20276 - 3.4.11.10,3.4.21.50 0.00000000000000001402 93.0
WLSH2_k127_6809675_0 Alanine-glyoxylate amino-transferase K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 428.0
WLSH2_k127_6860080_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 405.0
WLSH2_k127_6860080_1 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.0000000000000000000000000000000004973 132.0
WLSH2_k127_6863685_0 PFAM PEGA domain - - - 0.000000000000000000000000000000000011 146.0
WLSH2_k127_6863685_1 exopeptidase activity - - - 0.000000002409 67.0
WLSH2_k127_6870613_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009346 548.0
WLSH2_k127_6870613_1 Phosphate uptake regulator, PhoU - - - 0.0000000000000000000000000000000000000000000000000000000001102 216.0
WLSH2_k127_6870613_2 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000001805 206.0
WLSH2_k127_6870613_3 Belongs to the eukaryotic ribosomal protein eS6 family K02991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.0000000000000000000000000000000000000000005019 163.0
WLSH2_k127_6870613_4 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000002564 123.0
WLSH2_k127_6870613_5 structural constituent of ribosome K02974 - - 0.0000000000000000000008971 99.0
WLSH2_k127_6870613_6 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.0000000000000002762 79.0
WLSH2_k127_6870613_7 proteins of PilT N-term. Vapc superfamily K07158 - - 0.0000000000000006306 82.0
WLSH2_k127_6870613_8 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000002151 71.0
WLSH2_k127_6922075_0 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006972 308.0
WLSH2_k127_6922075_1 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.00000000000000000000000000000000000000000000000000000054 199.0
WLSH2_k127_6922075_2 Polyprenyl synthetase K02523,K13787 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.0000000000000000000000132 112.0
WLSH2_k127_6939728_0 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001177 281.0
WLSH2_k127_6939728_1 Predicted metal-binding protein (DUF2284) - - - 0.00000000000000000000000000000000000000000000001476 176.0
WLSH2_k127_6939728_2 transferase activity, transferring glycosyl groups K01365,K14475 - 3.4.22.15 0.000000000000000000000000000000000007345 155.0
WLSH2_k127_6939728_3 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000002107 107.0
WLSH2_k127_6939728_4 FR47-like protein - - - 0.00000000000000000106 92.0
WLSH2_k127_6940325_0 Cys/Met metabolism PLP-dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 404.0
WLSH2_k127_6940325_1 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 287.0
WLSH2_k127_6940325_2 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000005567 228.0
WLSH2_k127_6940325_3 - - - - 0.00000000000000000000000000000000000000000000000000000000002526 214.0
WLSH2_k127_6940325_4 phosphonoacetaldehyde hydrolase activity K01560,K07025 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000002045 196.0
WLSH2_k127_6940325_5 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000007533 177.0
WLSH2_k127_6940325_6 Protein of unknown function (DUF998) - - - 0.0000000000000000000000000000000000006098 146.0
WLSH2_k127_6940325_7 cell adhesion involved in biofilm formation - - - 0.0000000005519 71.0
WLSH2_k127_6940325_8 Calcineurin-like phosphoesterase K01120,K03651 - 3.1.4.17,3.1.4.53 0.00000005232 64.0
WLSH2_k127_6968936_0 Bacterial regulatory helix-turn-helix protein, lysR family K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000467 164.0
WLSH2_k127_6968936_1 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030880,GO:0031323,GO:0031326,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:1902494,GO:1903506,GO:1990234,GO:2000112,GO:2001141 - 0.0000000000000000000000000002161 117.0
WLSH2_k127_6968936_2 TIGRFAM molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.00000000000892 73.0
WLSH2_k127_6968936_3 Fosmidomycin resistance protein K08223 - - 0.000003365 58.0
WLSH2_k127_7003143_0 PFAM TPR repeat-containing protein - - - 0.00002898 57.0
WLSH2_k127_703715_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 1.115e-275 872.0
WLSH2_k127_703715_1 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 456.0
WLSH2_k127_703715_2 TIGRFAM geranylgeranyl reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001437 274.0
WLSH2_k127_703715_3 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000004788 208.0
WLSH2_k127_703715_4 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K04794 - 3.1.1.29 0.0000000000000000000000111 103.0
WLSH2_k127_703715_5 PRC-barrel domain - - - 0.00000000000002433 76.0
WLSH2_k127_703715_6 - - - - 0.000001425 57.0
WLSH2_k127_703715_7 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K04794 - 3.1.1.29 0.0002127 46.0
WLSH2_k127_7045940_0 NAD(P)H-binding K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 368.0
WLSH2_k127_7045940_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000001393 148.0
WLSH2_k127_7045940_2 Cold shock K03704 - - 0.000000000000000005249 85.0
WLSH2_k127_7085522_0 Tn3 transposase DDE domain - - - 0.0000000000000000000000000006561 117.0
WLSH2_k127_7085522_1 Belongs to the UPF0758 family K03630 - - 0.00000000000000000005375 90.0
WLSH2_k127_7085522_2 Belongs to the UPF0758 family K03630 - - 0.000000000000000004397 86.0
WLSH2_k127_7085522_3 Integrase core domain K07497 - - 0.00000003268 65.0
WLSH2_k127_7085522_4 - - - - 0.000002895 52.0
WLSH2_k127_7098481_0 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 475.0
WLSH2_k127_7098481_1 GTP-binding protein K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006507 293.0
WLSH2_k127_7098481_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000004049 212.0
WLSH2_k127_7098481_3 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000002479 138.0
WLSH2_k127_7098481_4 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.000000000000000000000000005719 114.0
WLSH2_k127_7098481_5 Zn-ribbon containing protein K07163 - - 0.000000000000000003363 91.0
WLSH2_k127_7098481_6 Putative exonuclease SbcCD, C subunit K03546 - - 0.00000000353 58.0
WLSH2_k127_7106660_0 Protein of unknown function (DUF763) K09003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 419.0
WLSH2_k127_7106660_1 metal ion transmembrane transporter activity - - - 0.0000000000000000000000000000000000001384 156.0
WLSH2_k127_7106660_2 Acyl-protein synthetase, LuxE - - - 0.000000000000000000000000001351 127.0
WLSH2_k127_7106660_3 Transglutaminase-like superfamily - - - 0.00000004955 64.0
WLSH2_k127_7106660_4 PFAM Transglutaminase-like - - - 0.00004851 54.0
WLSH2_k127_7111674_0 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 351.0
WLSH2_k127_7111674_1 Methylene-tetrahydrofolate reductase C terminal - - - 0.000000000000000000000000000000000000000000000000000000002325 206.0
WLSH2_k127_7111674_2 PFAM UbiA prenyltransferase K17105 - 2.5.1.42 0.000000000122 73.0
WLSH2_k127_7111674_3 FAD dependent oxidoreductase K09516,K09835 - 1.3.99.23,5.2.1.13 0.0000000006418 70.0
WLSH2_k127_7154342_0 Amino acid permease - - - 5.247e-270 845.0
WLSH2_k127_7154342_1 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.00000000004218 75.0
WLSH2_k127_7182460_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 395.0
WLSH2_k127_7182460_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004145 276.0
WLSH2_k127_7182460_2 Forms part of the polypeptide exit tunnel K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002046 258.0
WLSH2_k127_7182460_3 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000008887 158.0
WLSH2_k127_7182460_4 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000347 75.0
WLSH2_k127_7182460_5 Winged helix-turn-helix domain (DUF2582) - - - 0.000008665 53.0
WLSH2_k127_7182460_6 Winged helix-turn-helix domain (DUF2582) - - - 0.00005575 51.0
WLSH2_k127_7182857_0 coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 457.0
WLSH2_k127_7182857_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008976 353.0
WLSH2_k127_7182857_2 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000006615 252.0
WLSH2_k127_7253447_0 Flavin containing amine oxidoreductase K10027,K20611 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,1.3.99.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007241 561.0
WLSH2_k127_7253447_1 Phytoene squalene synthetase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006821 334.0
WLSH2_k127_7253447_2 - - - - 0.0000184 48.0
WLSH2_k127_7257706_0 CoA binding domain K01905 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000821 227.0
WLSH2_k127_7257706_1 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000000000000000001321 146.0
WLSH2_k127_7257706_2 ArsR transcriptional regulator - - - 0.0000000000000000000000000000001328 130.0
WLSH2_k127_7275138_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000163 221.0
WLSH2_k127_7275138_1 PFAM NAD dependent epimerase dehydratase family - - - 0.0000000000000000000000000000000000000000000002361 179.0
WLSH2_k127_7275138_2 aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.000000000000000000000000000000000000000000001906 168.0
WLSH2_k127_7275138_3 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000009693 163.0
WLSH2_k127_7275138_4 UbiA prenyltransferase family K03179,K17105 - 2.5.1.39,2.5.1.42 0.00000000000000000000000000000000000001045 157.0
WLSH2_k127_7275138_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.0000000000001983 79.0
WLSH2_k127_7275138_6 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000001822 61.0
WLSH2_k127_7295418_0 PFAM DNA methylase N-4 N-6 domain protein K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 330.0
WLSH2_k127_7295418_1 glutamine synthetase, type I K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 342.0
WLSH2_k127_7295418_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168,K18707 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.3,2.8.4.5 0.000000000000000000000000008079 121.0
WLSH2_k127_7332885_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000002948 264.0
WLSH2_k127_7332885_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000006273 100.0
WLSH2_k127_7332885_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131 - 0.00000000002453 68.0
WLSH2_k127_7381788_0 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000001029 220.0
WLSH2_k127_7381788_1 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000007872 184.0
WLSH2_k127_7381788_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000003263 104.0
WLSH2_k127_7381788_3 Lrp/AsnC ligand binding domain - - - 0.000000000000000000008563 94.0
WLSH2_k127_7398226_0 PFAM thymidine kinase K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007045 279.0
WLSH2_k127_7398226_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000006466 237.0
WLSH2_k127_7398226_2 Binds the 23S rRNA K02909 - - 0.000000000000000000000000000000000000000000000000000000000000007897 219.0
WLSH2_k127_7398226_3 Selenocysteine-specific translation elongation factor K03833 - - 0.00000000000000000000000000000000000000000002026 171.0
WLSH2_k127_7398226_4 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000000000000000000000000001603 151.0
WLSH2_k127_7398226_5 Ribosomal L27 protein K02899 - - 0.0000000000000000000000000000000000002457 141.0
WLSH2_k127_7408321_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 550.0
WLSH2_k127_7408321_1 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000008245 230.0
WLSH2_k127_7456495_0 PFAM PKD domain containing protein - - - 0.000000000000002017 83.0
WLSH2_k127_7490432_0 Domain of unknown function (DUF4143) K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 490.0
WLSH2_k127_7490432_1 Periplasmic copper-binding protein (NosD) - - - 0.0000000000003405 79.0
WLSH2_k127_7490432_2 Belongs to the 'phage' integrase family - - - 0.00005185 55.0
WLSH2_k127_7490432_3 Cytidylate kinase-like family - - - 0.0004458 49.0
WLSH2_k127_7501252_0 Alanine dehydrogenase/PNT, N-terminal domain K00290,K14157 - 1.5.1.7,1.5.1.8,1.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005311 495.0
WLSH2_k127_7501252_1 Saccharopine dehydrogenase C-terminal domain K00293 - 1.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 490.0
WLSH2_k127_7501252_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K03918 - 2.6.1.19,2.6.1.36 0.0000000000000000000009015 100.0
WLSH2_k127_7530114_0 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000006919 128.0
WLSH2_k127_7530114_1 membrane-associated protein domain - - - 0.0000000605 65.0
WLSH2_k127_7548738_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 358.0
WLSH2_k127_7548738_1 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000000571 238.0
WLSH2_k127_7548738_2 Phosphate transport system permease K02038 - - 0.00000000000000000000000000000000000000000000000000000000391 203.0
WLSH2_k127_7550936_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 476.0
WLSH2_k127_7550936_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 368.0
WLSH2_k127_7550936_10 PIN domain of ribonuclease K07060 - - 0.0000000000000000000009446 102.0
WLSH2_k127_7550936_11 COG2002 Regulators of stationary sporulation gene expression - - - 0.0000000003326 62.0
WLSH2_k127_7550936_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 336.0
WLSH2_k127_7550936_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036,K02068,K06857 - 3.6.3.27,3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 318.0
WLSH2_k127_7550936_4 ABC-type phosphate transport system, periplasmic component K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 319.0
WLSH2_k127_7550936_5 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007767 272.0
WLSH2_k127_7550936_6 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003247 257.0
WLSH2_k127_7550936_7 Binding-protein-dependent transport system inner membrane component K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000005986 237.0
WLSH2_k127_7550936_8 BioY protein K03523 - - 0.00000000000000000000000000000000000000000000000000000000000000004205 229.0
WLSH2_k127_7550936_9 Signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000004399 126.0
WLSH2_k127_7551939_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001715 259.0
WLSH2_k127_7582114_0 nitric oxide - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008811 452.0
WLSH2_k127_7582114_1 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 433.0
WLSH2_k127_7582114_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005802 402.0
WLSH2_k127_7582114_3 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003896 358.0
WLSH2_k127_7582114_4 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001832 284.0
WLSH2_k127_7582114_5 Peptidase family C25 - - - 0.0000001446 64.0
WLSH2_k127_7677393_0 COG3209 Rhs family protein - GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0004549,GO:0006139,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016078,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - 0.00001124 55.0
WLSH2_k127_7677393_1 Peptidase family M28 - - - 0.0002687 53.0
WLSH2_k127_7814193_0 - - - - 0.000000000005922 72.0
WLSH2_k127_7814193_1 - - - - 0.0006332 52.0
WLSH2_k127_7844017_0 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000000000000000000000000000000000000361 215.0
WLSH2_k127_7844017_1 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000002097 207.0
WLSH2_k127_7844017_2 reductase - - - 0.0000000000000000001723 101.0
WLSH2_k127_7844017_3 radical SAM domain protein - - - 0.0000000000000003431 79.0
WLSH2_k127_7877664_0 ABC transporter, ATP-binding protein K02003 - - 0.00000000000000000000000000000000000000000000000000000000005422 208.0
WLSH2_k127_7877664_1 Secreted protein with C-terminal beta-propeller domain - - - 0.000000000000000000000000000000001599 142.0
WLSH2_k127_7877664_2 Domain of unknown function DUF83 K07464 - 3.1.12.1 0.00000000000000000000000001248 117.0
WLSH2_k127_7877664_3 Predicted membrane protein (DUF2318) - - - 0.000000000000000000000003004 108.0
WLSH2_k127_7877664_5 - - - - 0.00004901 49.0
WLSH2_k127_7921832_0 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000001563 171.0
WLSH2_k127_7932897_0 Peptidase family C25 - - - 0.0000000000002057 84.0
WLSH2_k127_7932897_1 helix_turn_helix ASNC type K03719 - - 0.0002432 50.0
WLSH2_k127_7951351_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005566 325.0
WLSH2_k127_7951351_1 - - - - 0.00001303 55.0
WLSH2_k127_7951351_2 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.000952 47.0
WLSH2_k127_7998536_0 Thioredoxin K03671 - - 0.000000000000000000000000000000000000001729 150.0
WLSH2_k127_7998536_1 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000001606 155.0
WLSH2_k127_7998536_2 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000002027 92.0
WLSH2_k127_7998536_3 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0005913 44.0
WLSH2_k127_8001042_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 8.826e-206 646.0
WLSH2_k127_8001042_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 567.0
WLSH2_k127_8001042_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000002538 233.0
WLSH2_k127_8001042_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000001949 150.0
WLSH2_k127_8051507_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 300.0
WLSH2_k127_8051507_1 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000002044 250.0
WLSH2_k127_8051507_2 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000001126 236.0
WLSH2_k127_8051507_3 Exosome complex component K07573 - - 0.0005623 44.0
WLSH2_k127_8097480_0 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 384.0
WLSH2_k127_8097480_1 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 330.0
WLSH2_k127_8097480_2 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.000000000000000000002547 94.0
WLSH2_k127_8097480_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000001004 77.0
WLSH2_k127_8097480_4 PFAM regulatory protein, ArsR K03892,K21903 - - 0.000000000000001388 79.0
WLSH2_k127_8097480_6 COG1668 ABC-type Na efflux pump, permease component - - - 0.000000002355 67.0
WLSH2_k127_8165153_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 4.6e-198 626.0
WLSH2_k127_8165153_1 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 289.0
WLSH2_k127_8165153_2 regulator of amino acid metabolism K07103 - - 0.00000000000000000000000000000000001564 141.0
WLSH2_k127_8368620_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 484.0
WLSH2_k127_8368620_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008512 353.0
WLSH2_k127_8368620_2 - - - - 0.000000000000000000000001541 108.0
WLSH2_k127_8368620_3 Uncharacterized protein conserved in bacteria (DUF2090) K03338 - 2.7.1.92 0.00004016 55.0
WLSH2_k127_8396490_0 metal-binding domain in RNase L inhibitor, RLI K06174 GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006135 522.0
WLSH2_k127_8396490_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 468.0
WLSH2_k127_8396490_2 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 368.0
WLSH2_k127_8396490_3 Cold shock protein domain K03704 - - 0.00000000000000001002 84.0
WLSH2_k127_8396490_4 alpha-amylase - - - 0.0000005519 57.0
WLSH2_k127_8428497_0 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000000629 197.0
WLSH2_k127_8428497_1 TraB family - - - 0.0000000000000000000000000000000000565 143.0
WLSH2_k127_8428497_2 PFAM Radical SAM domain protein - - - 0.0000000000000000017 93.0
WLSH2_k127_8428497_3 Thrombospondin type 3 repeat - - - 0.00001521 52.0
WLSH2_k127_8428497_4 PFAM Radical SAM domain protein - - - 0.00002367 46.0
WLSH2_k127_8467465_0 Radical SAM domain protein K06937 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 468.0
WLSH2_k127_8467465_1 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000232 254.0
WLSH2_k127_8467465_2 Belongs to the peptidase M28 family - - - 0.00000000000000000000004885 113.0
WLSH2_k127_8467465_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000008255 80.0
WLSH2_k127_8640298_0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 436.0
WLSH2_k127_8640298_1 Conserved hypothetical ATP binding protein K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004624 248.0
WLSH2_k127_8640298_2 protein conserved in archaea K09746 - - 0.0000000005494 67.0
WLSH2_k127_8689355_0 mechanosensitive ion channel K16052 - - 0.00000000000000000000000000000000000000000000000000000000000001829 229.0
WLSH2_k127_8689355_1 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.00000000000000000000000000000000000000000000000747 175.0
WLSH2_k127_8689355_2 Phosphate-starvation-inducible E - - - 0.000000000000007218 80.0
WLSH2_k127_8689355_3 glucosylceramidase activity - - - 0.0000000002284 66.0
WLSH2_k127_8689355_4 PAC2 family K06869 - - 0.000000009896 60.0
WLSH2_k127_8728004_0 Aconitase family (aconitate hydratase) K01703,K01705,K16792 - 4.2.1.114,4.2.1.33,4.2.1.35,4.2.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000001038 259.0
WLSH2_k127_8728004_1 Chlorophyllase enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000008745 238.0
WLSH2_k127_8728004_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000004973 185.0
WLSH2_k127_8730317_0 helicase superfamily c-terminal domain K03724 - - 3.553e-233 749.0
WLSH2_k127_8730317_1 Radical_SAM C-terminal domain K07739 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 570.0
WLSH2_k127_8744352_0 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.1.1.65 0.0000000000000000000000000000000000002834 150.0
WLSH2_k127_8744352_1 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000155 118.0
WLSH2_k127_8744352_2 Psort location CytoplasmicMembrane, score K17103 - 2.7.8.8 0.000000007146 64.0
WLSH2_k127_8759609_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001315 274.0
WLSH2_k127_8759609_1 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.00000000000000000000000000000000000001537 149.0
WLSH2_k127_8759609_2 PFAM 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000001224 114.0
WLSH2_k127_8759609_3 - - - - 0.0000000000009565 69.0
WLSH2_k127_8759609_4 - - - - 0.00000000001081 65.0
WLSH2_k127_8759609_5 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000009296 57.0
WLSH2_k127_8759609_6 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00001486 51.0
WLSH2_k127_8776172_0 SMART Prolyl 4-hydroxylase, alpha subunit - - - 0.0000000000000000000000000000000000000000000000000005608 199.0
WLSH2_k127_8776172_1 Shikimate quinate 5-dehydrogenase - - - 0.0000000000000000000000000032 122.0
WLSH2_k127_879451_0 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007853 285.0
WLSH2_k127_879451_1 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000002917 222.0
WLSH2_k127_879451_2 PAC2 family K06869 - - 0.000000000000000000000000000000000000000000000149 177.0
WLSH2_k127_879451_3 Phosphoglycolate phosphatase K01091 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18 0.00000000000000000002748 98.0
WLSH2_k127_879451_4 Lrp/AsnC ligand binding domain - - - 0.00000000000000000005725 92.0
WLSH2_k127_879451_5 ABC transporter K01990,K09695 - - 0.0007058 43.0
WLSH2_k127_8841020_0 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000000003236 238.0
WLSH2_k127_8841020_1 PFAM ABC transporter K02028 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000005708 213.0
WLSH2_k127_8841020_2 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.0000000000000000000000000000000000001301 147.0
WLSH2_k127_8841020_3 PFAM conserved K07027 - - 0.00000009559 63.0
WLSH2_k127_8863475_0 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 329.0
WLSH2_k127_8863475_1 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000006072 192.0
WLSH2_k127_8863475_2 PRC-barrel domain - - - 0.00000000000003115 76.0
WLSH2_k127_8863475_3 Uncharacterized protein containing a Zn-ribbon (DUF2116) - - - 0.0004591 45.0
WLSH2_k127_8879668_0 Phenylalanyl-tRNA synthetase beta K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006739 349.0
WLSH2_k127_8879668_1 B3/4 domain K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000003735 149.0
WLSH2_k127_8879668_2 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000005796 107.0
WLSH2_k127_8929273_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 445.0
WLSH2_k127_8929273_1 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 298.0
WLSH2_k127_8929273_2 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.0001591 47.0
WLSH2_k127_8933430_0 DNA primase K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004996 415.0
WLSH2_k127_8933430_1 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 295.0
WLSH2_k127_8933430_2 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.000000000000000000000003463 108.0
WLSH2_k127_8933430_3 belongs to the glycosyl hydrolase 13 family K01176,K01208 - 3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.54 0.000000000000000008292 85.0
WLSH2_k127_8933430_4 Uncharacterised protein family UPF0058 - - - 0.0000000004878 64.0
WLSH2_k127_8939371_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001315 274.0
WLSH2_k127_8939371_1 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.000000000000000000000000000000000000001263 152.0
WLSH2_k127_8939371_2 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000008126 118.0
WLSH2_k127_8939371_3 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000001141 60.0
WLSH2_k127_9095694_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 296.0
WLSH2_k127_9095694_1 RNA-binding protein of the translin family K07477 - - 0.00000000000000000000000000001801 123.0
WLSH2_k127_9238323_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 381.0
WLSH2_k127_9238323_1 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000009879 203.0
WLSH2_k127_9297041_0 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000009513 238.0
WLSH2_k127_9297041_1 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 - - 0.0000000000000000000000000000000000000008378 151.0
WLSH2_k127_9371313_0 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 333.0
WLSH2_k127_9371313_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 330.0
WLSH2_k127_9371313_10 Dinitrogenase iron-molybdenum cofactor - - - 0.00000000004885 65.0
WLSH2_k127_9371313_11 membrane-associated protein domain - - - 0.0005734 46.0
WLSH2_k127_9371313_2 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 324.0
WLSH2_k127_9371313_3 Bacterial transferase hexapeptide (six repeats) K02617,K08279 - - 0.000000000000000000000000000000000000000000000000000000000000002652 222.0
WLSH2_k127_9371313_4 PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis - - - 0.0000000000000000000000000000000000000003408 152.0
WLSH2_k127_9371313_5 Zn_pept K05996 - 3.4.17.18 0.00000000000000000000000000000000000189 153.0
WLSH2_k127_9371313_6 Dinitrogenase iron-molybdenum cofactor - - - 0.0000000000000000000000000000000004425 134.0
WLSH2_k127_9371313_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000001003 118.0
WLSH2_k127_9371313_8 Family of unknown function (DUF5320) - - - 0.000000000000000000005306 96.0
WLSH2_k127_9371313_9 nitrogen fixation - - - 0.0000000000000000009603 87.0
WLSH2_k127_9389416_0 Methyltransferase - - - 0.000000000008519 74.0
WLSH2_k127_9391533_0 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 364.0
WLSH2_k127_9391533_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000004188 243.0
WLSH2_k127_9391533_2 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000000000442 236.0
WLSH2_k127_9391533_3 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000401 223.0
WLSH2_k127_9391533_4 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.0002864 53.0
WLSH2_k127_9398_0 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 315.0
WLSH2_k127_9398_1 Sulphur oxygenase reductase K03151,K16952 - 1.13.11.55,2.8.1.4 0.00000000000000000000000000000000000000000000000000186 188.0
WLSH2_k127_9398_2 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.0000000000000000000000000000000000000000000000003553 183.0
WLSH2_k127_9398_3 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000000000000000000000002039 139.0
WLSH2_k127_9398_4 Glutaredoxin - - - 0.0000000000000000000003614 98.0
WLSH2_k127_9398_5 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.00005332 52.0
WLSH2_k127_946181_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.11e-299 930.0
WLSH2_k127_946181_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.069e-239 751.0
WLSH2_k127_946181_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 613.0
WLSH2_k127_946181_3 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 312.0
WLSH2_k127_946181_4 Psort location Cytoplasmic, score 8.96 - - - 0.000000000205 67.0
WLSH2_k127_9579048_0 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 341.0
WLSH2_k127_9579048_1 regulatory protein, arsR K03892,K21903 - - 0.00000000000000000008989 91.0
WLSH2_k127_9579048_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000002782 72.0
WLSH2_k127_959004_0 Papain family cysteine protease K11751,K14647 - 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000001523 153.0
WLSH2_k127_959004_1 transcriptional - GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.0001018 47.0
WLSH2_k127_9625445_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 439.0
WLSH2_k127_9625445_1 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007294 249.0
WLSH2_k127_9625445_2 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000003462 203.0
WLSH2_k127_9625445_3 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000005133 197.0
WLSH2_k127_9625445_4 - - - - 0.000003052 51.0
WLSH2_k127_9631483_0 Disaggregatase related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001053 297.0
WLSH2_k127_9631483_1 membrane - - - 0.00000000000000000000000000000000000000000000000002112 187.0
WLSH2_k127_9631483_2 Protein of unknown function (DUF1616) - - - 0.0003405 46.0
WLSH2_k127_9725476_0 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000001292 160.0
WLSH2_k127_9772140_0 COG1131 ABC-type multidrug transport system ATPase component K16907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 358.0
WLSH2_k127_9772140_1 transmembrane transport K01992 - - 0.0000000005772 64.0
WLSH2_k127_9855734_0 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0000000000000000000000000000000000000000000000000000000000005478 222.0
WLSH2_k127_9855734_1 PFAM HD domain K03698 - - 0.00000000000000000000000000000000000000000000000000000000005631 218.0
WLSH2_k127_9855734_2 Trm112p-like protein - - - 0.00000000000000006554 81.0
WLSH2_k127_9866560_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 335.0
WLSH2_k127_9866560_1 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 305.0
WLSH2_k127_9866560_2 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.00000000000000000000000000000000000000000000000000000000000001258 224.0
WLSH2_k127_9866560_3 - - - - 0.00000000000000007637 82.0
WLSH2_k127_9866560_4 - - - - 0.000000001186 71.0
WLSH2_k127_988701_0 KH, type 1, domain K07041 - - 1.147e-260 816.0
WLSH2_k127_988701_1 pyridoxal phosphate-dependent acyltransferase K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 452.0
WLSH2_k127_988701_2 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001339 282.0
WLSH2_k127_988701_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000001216 244.0
WLSH2_k127_988701_4 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.00000000000000000000000000000000000001069 151.0
WLSH2_k127_9911599_0 Pyridoxal-phosphate dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 316.0
WLSH2_k127_9911599_1 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.00000000000000000000000000000000000000000000000000000000004893 214.0
WLSH2_k127_9911599_2 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.1.1.65 0.000000000000000000000000000000000000007225 152.0
WLSH2_k127_9911599_3 Belongs to the PAPS reductase family. CysH subfamily K00390 GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8 0.0000000000000000000000000002335 132.0
WLSH2_k127_9911599_4 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) K01807 - 5.3.1.6 0.00000000000000000005229 92.0
WLSH2_k127_9939223_0 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 476.0
WLSH2_k127_9939223_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000003158 154.0
WLSH2_k127_9955177_0 Nickel-dependent hydrogenase K00436,K14126 - 1.12.1.2,1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 496.0
WLSH2_k127_9955177_1 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000002224 230.0
WLSH2_k127_9955177_2 COG0517 FOG CBS domain - - - 0.000000000000000003006 91.0