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Overview

ID MAG04416
Name XH2_bin.34
Sample SMP0119
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family Methanospirillaceae
Genus UBA9949
Species
Assembly information
Completeness (%) 55.54
Contamination (%) 0.63
GC content (%) 56.0
N50 (bp) 4,331
Genome size (bp) 888,170

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1067

Gene name Description KEGG GOs EC E-value Score Sequence
XH2_k127_10001961_0 PFAM aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008599 582.0
XH2_k127_10001961_1 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003453 275.0
XH2_k127_10001961_2 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001359 271.0
XH2_k127_10001961_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000002117 187.0
XH2_k127_10001961_4 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000001525 160.0
XH2_k127_10012760_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 5.478e-228 707.0
XH2_k127_10012760_1 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 363.0
XH2_k127_10012760_2 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000002556 204.0
XH2_k127_10023423_0 DEAD DEAH box helicase domain protein K03725 - - 4.846e-288 897.0
XH2_k127_10023423_1 SMART regulatory protein, Crp K07730 - - 0.0000000000000000000000000000000000000000000000000000000000000000006515 229.0
XH2_k127_10026309_0 TIGRFAM formate dehydrogenase family accessory protein FdhD K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006945 250.0
XH2_k127_10026309_1 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000005591 199.0
XH2_k127_10026309_2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000005117 154.0
XH2_k127_10026309_3 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000005367 107.0
XH2_k127_10026309_4 PFAM Uncharacterised conserved protein UCP006577 - - - 0.0000000000000000916 83.0
XH2_k127_10061659_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 3.996e-198 623.0
XH2_k127_10061659_1 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 291.0
XH2_k127_10061659_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.0008007 44.0
XH2_k127_10163712_0 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008364 275.0
XH2_k127_10163712_1 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.000000000000000000000000000000000000000000000000000000000000000000000000000228 261.0
XH2_k127_10163712_2 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000007195 183.0
XH2_k127_10163712_3 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.00000000000000000000000000000000000000000000001328 177.0
XH2_k127_10163712_4 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.00000000000000000000000000000000001227 137.0
XH2_k127_10163712_5 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.000007034 51.0
XH2_k127_10245297_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 508.0
XH2_k127_10245297_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004582 331.0
XH2_k127_10245297_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008133 300.0
XH2_k127_10245297_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 289.0
XH2_k127_10245297_4 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001576 282.0
XH2_k127_10245297_5 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000002992 203.0
XH2_k127_10245297_6 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000000008148 200.0
XH2_k127_10245297_7 Ribosomal protein S23 K02973 - - 0.0000000000000000000000000000000001611 136.0
XH2_k127_10264402_0 PhoU domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008211 411.0
XH2_k127_10264402_1 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000553 337.0
XH2_k127_10264402_2 PBP superfamily domain K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 313.0
XH2_k127_10264402_3 PFAM Orn Lys Arg decarboxylase major region K01584 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000005218 214.0
XH2_k127_10266196_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 417.0
XH2_k127_10266196_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 365.0
XH2_k127_10266196_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007472 268.0
XH2_k127_10266196_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000596 211.0
XH2_k127_10266196_4 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00000000000000000000000000000000000000000000000000000000009583 210.0
XH2_k127_10266196_5 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000000000000000000000001105 156.0
XH2_k127_10285206_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 330.0
XH2_k127_10285206_1 Nitroreductase - - - 0.000000001617 61.0
XH2_k127_10316411_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 4.862e-253 786.0
XH2_k127_10316411_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 474.0
XH2_k127_10316411_2 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009328 404.0
XH2_k127_10316411_3 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000003283 135.0
XH2_k127_10316411_4 Condensation domain - - - 0.000000006268 62.0
XH2_k127_10340132_0 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000002312 177.0
XH2_k127_10340132_1 Small multi-drug export protein - - - 0.000000000000000000000000000000000000001024 153.0
XH2_k127_10340132_2 - - - - 0.0000000001292 68.0
XH2_k127_10433226_0 PFAM Radical SAM domain protein K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 506.0
XH2_k127_10433226_1 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 498.0
XH2_k127_10433226_2 RuvA, C-terminal domain K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000008187 244.0
XH2_k127_10433226_3 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000000000000000004022 222.0
XH2_k127_1046195_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 462.0
XH2_k127_1046195_1 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002539 270.0
XH2_k127_1046195_2 Tellurite resistance protein TerB - - - 0.00000000000000000000000000000000000000000000000001033 183.0
XH2_k127_10473097_0 Belongs to the TCP-1 chaperonin family K22447 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000973 286.0
XH2_k127_10473097_1 protein possibly involved in aromatic compounds catabolism K02614 - - 0.0000000000000000000000000000004743 126.0
XH2_k127_10473097_2 Sulfur transfer protein involved in thiamine biosynthesis K03154,K21947 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.8.1.15 0.0000001332 55.0
XH2_k127_10485545_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 4.652e-225 702.0
XH2_k127_10485545_1 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000001983 159.0
XH2_k127_10485545_2 zinc finger, SWIM - - - 0.000000000000000000000000000000006976 130.0
XH2_k127_10518954_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 465.0
XH2_k127_10518954_1 Ribonuclease H K03469 - 3.1.26.4 0.00000000000000000000000000001002 123.0
XH2_k127_10518954_2 - - - - 0.0000000000000000000000000006088 115.0
XH2_k127_10555421_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 6.513e-199 621.0
XH2_k127_10555421_1 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000002276 234.0
XH2_k127_10555421_2 PFAM PRC-barrel domain - - - 0.0000000000000000000000000000000000000006952 149.0
XH2_k127_10555421_3 transcription factor (CBF NF-Y) - - - 0.0000000000000000000000000001414 115.0
XH2_k127_10555421_4 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000003059 83.0
XH2_k127_10577541_0 methylase K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000856 354.0
XH2_k127_10577541_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 347.0
XH2_k127_10577541_2 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 281.0
XH2_k127_10577541_3 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000009116 263.0
XH2_k127_1068360_0 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 453.0
XH2_k127_1068360_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 422.0
XH2_k127_1069089_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 558.0
XH2_k127_1069089_1 protein conserved in archaea K09746 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000345 283.0
XH2_k127_1069089_2 Cysteine-rich small domain K08260 - 3.5.1.90 0.000000000000000000000000000000000000000000000001487 175.0
XH2_k127_1069089_3 Domain of unknown function (DUF1858) - - - 0.0000000000000000000000002681 105.0
XH2_k127_1069089_4 Ferredoxin K05337 - - 0.0000000000000000005184 88.0
XH2_k127_1069089_5 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.0000000000005831 69.0
XH2_k127_10743690_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 542.0
XH2_k127_10743690_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 445.0
XH2_k127_10743690_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002829 266.0
XH2_k127_10743690_3 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000007432 208.0
XH2_k127_10743690_4 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000006302 213.0
XH2_k127_1099766_0 PHP C-terminal domain protein - - - 1.828e-201 633.0
XH2_k127_1099766_1 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000001142 226.0
XH2_k127_1099766_2 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000001575 141.0
XH2_k127_1099766_3 PFAM beta-lactamase domain protein - - - 0.000000000000002971 76.0
XH2_k127_1099766_4 Domain of unknown function (DUF4405) - - - 0.000000000000375 74.0
XH2_k127_1099766_5 PFAM beta-lactamase domain protein - - - 0.0000000008363 60.0
XH2_k127_113268_0 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 306.0
XH2_k127_113268_1 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000719 247.0
XH2_k127_113268_2 - - - - 0.0000000000000000000000000000000000000000005888 172.0
XH2_k127_113268_3 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000006436 100.0
XH2_k127_113268_4 cell adhesion involved in biofilm formation - - - 0.000000000000002874 88.0
XH2_k127_1199401_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.25e-248 778.0
XH2_k127_1199401_1 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 331.0
XH2_k127_1367367_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1057.0
XH2_k127_1367367_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 409.0
XH2_k127_1376857_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 537.0
XH2_k127_1376857_1 PFAM sigma-70 region 4 domain protein K09714 - - 0.0000000000000000000000000000000000000000000000000000000000006716 212.0
XH2_k127_1376857_2 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.00000000000000000000000000000000000000000003827 161.0
XH2_k127_1376857_3 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.0000000000001854 73.0
XH2_k127_1515255_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009889 429.0
XH2_k127_1515255_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009281 274.0
XH2_k127_1515255_2 Phosphate transport regulator - - - 0.0001351 46.0
XH2_k127_1545841_0 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007945 321.0
XH2_k127_1545841_1 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 302.0
XH2_k127_1545841_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005129 259.0
XH2_k127_1557583_0 PFAM Radical SAM domain protein K06937 - - 9.869e-247 769.0
XH2_k127_1557583_1 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 394.0
XH2_k127_1557583_2 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.00000000000000000000000000000000000000000000000000000000001297 215.0
XH2_k127_1557583_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000006576 183.0
XH2_k127_1557583_4 Small multi-drug export protein - - - 0.00000000000000000000000000001203 123.0
XH2_k127_1559626_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 559.0
XH2_k127_1559626_1 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 420.0
XH2_k127_1559626_10 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.000000000000000000000000000000000002478 142.0
XH2_k127_1559626_11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.0000000000000000000000000000001285 125.0
XH2_k127_1559626_12 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.000000000000000000000757 95.0
XH2_k127_1559626_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 370.0
XH2_k127_1559626_3 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 347.0
XH2_k127_1559626_4 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 341.0
XH2_k127_1559626_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002151 253.0
XH2_k127_1559626_6 Located on the platform of the 30S subunit K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006044 244.0
XH2_k127_1559626_7 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000001317 220.0
XH2_k127_1559626_8 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000003111 207.0
XH2_k127_1559626_9 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.000000000000000000000000000000000000000000000002899 176.0
XH2_k127_1588548_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 1.326e-287 892.0
XH2_k127_1588548_1 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003449 246.0
XH2_k127_1588548_2 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000006235 214.0
XH2_k127_1588548_3 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000000006566 183.0
XH2_k127_1588548_4 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.00000000000000000000000000000000000000000001289 168.0
XH2_k127_1588548_5 - - - - 0.0000000000000000000000000000000000000000000297 171.0
XH2_k127_1588548_6 Protein of unknown function DUF134 K06933 - - 0.000001183 53.0
XH2_k127_161206_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 577.0
XH2_k127_161206_1 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 463.0
XH2_k127_161206_2 PFAM metallophosphoesterase K07096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 298.0
XH2_k127_161206_3 Belongs to the UPF0107 family K09128 - - 0.00000000000000000000000000000000000000000000000000002459 191.0
XH2_k127_161206_4 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.00000000000000000000000000000000000000000000000002904 184.0
XH2_k127_161206_5 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.000000000000000000000000006638 114.0
XH2_k127_161206_6 TIR domain - - - 0.00000000000000000006532 94.0
XH2_k127_161206_7 - - - - 0.000000000001239 70.0
XH2_k127_163243_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006718 462.0
XH2_k127_163243_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009931 288.0
XH2_k127_163243_2 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002998 246.0
XH2_k127_163243_3 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.0000000000000000000000000000000000000000000000000003073 196.0
XH2_k127_163243_4 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000000000000000007592 125.0
XH2_k127_163243_5 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.000000000000000000000002597 102.0
XH2_k127_1638853_0 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 506.0
XH2_k127_1638853_1 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005988 453.0
XH2_k127_1638853_2 PFAM PRC-barrel domain - - - 0.000000000000000000000001458 104.0
XH2_k127_1646033_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 2.676e-281 874.0
XH2_k127_1646033_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 309.0
XH2_k127_1656206_0 Protein of unknown function (DUF1648) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002098 253.0
XH2_k127_1656206_1 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000001887 156.0
XH2_k127_1656206_2 peptide deformylase activity K01462 - 3.5.1.88 0.00000000000000000000000000009119 127.0
XH2_k127_1743130_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 601.0
XH2_k127_1743130_1 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000004751 230.0
XH2_k127_1743130_2 - - - - 0.0000000000000000000000000000000000000004236 156.0
XH2_k127_1745409_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007884 486.0
XH2_k127_1745409_1 SOS response associated peptidase (SRAP) - - - 0.0000000000000000000000000000000000000000000000000000001564 199.0
XH2_k127_1745409_2 - - - - 0.0000000000000000000000000000000000000001551 152.0
XH2_k127_1745409_3 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.0006314 45.0
XH2_k127_1817319_0 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 1.883e-279 869.0
XH2_k127_1817319_1 DEAD DEAH box helicase domain protein K10896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000051 498.0
XH2_k127_1817319_2 - - - - 0.0000000001683 65.0
XH2_k127_2103578_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006293 529.0
XH2_k127_2103578_1 Concanavalin A-like lectin/glucanases superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 376.0
XH2_k127_2139357_0 signal-transduction protein containing cAMP-binding and CBS domains K01425 GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 0.00000000000000000000000000000000005323 138.0
XH2_k127_2139357_1 Nitroreductase - - - 0.00000000000000000000000534 109.0
XH2_k127_2139357_2 PFAM ABC-2 type transporter K09694 - - 0.00000000000000006554 82.0
XH2_k127_2139357_3 PQ loop repeat K15383 - - 0.00000000004185 66.0
XH2_k127_2209301_0 PFAM TatD-related deoxyribonuclease K07049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 373.0
XH2_k127_2209301_1 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 339.0
XH2_k127_2209301_2 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.00000000000000000000000000000000000000000000000000000000000000000000006276 247.0
XH2_k127_2209301_3 Belongs to the MCM family K10726 - - 0.000000000000000000000000000000000000000000000000000000002586 202.0
XH2_k127_2209301_4 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.00000000000000000000000000000001307 130.0
XH2_k127_2209301_5 Protein of unknown function (DUF424) K09148 - - 0.0000000000000000000000002272 108.0
XH2_k127_2278143_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 411.0
XH2_k127_2278143_1 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008071 378.0
XH2_k127_2278143_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004184 289.0
XH2_k127_2278143_3 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000001406 207.0
XH2_k127_2278143_4 - - - - 0.000000000000000000000000000000000000006242 155.0
XH2_k127_2386354_0 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 2.195e-243 761.0
XH2_k127_2386354_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 9.971e-242 758.0
XH2_k127_2386354_2 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004594 395.0
XH2_k127_2386354_3 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 377.0
XH2_k127_2386354_4 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007011 281.0
XH2_k127_2386354_5 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.000000000000000001184 86.0
XH2_k127_2396731_0 Amidinotransferase K01478 - 3.5.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 531.0
XH2_k127_2396731_1 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009523 382.0
XH2_k127_2396731_2 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003587 280.0
XH2_k127_2396731_3 small multi-drug export - - - 0.000000000000000000000000000000000004465 145.0
XH2_k127_2396731_4 - - - - 0.000000000000000000009382 94.0
XH2_k127_2406607_0 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 414.0
XH2_k127_2406607_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007937 369.0
XH2_k127_2406607_2 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000006345 177.0
XH2_k127_240879_0 AAA domain - - - 1.044e-240 767.0
XH2_k127_240879_1 Belongs to the glutamate synthase family - - - 9.09e-220 693.0
XH2_k127_240879_2 PFAM zinc iron permease K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008214 351.0
XH2_k127_240879_3 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 344.0
XH2_k127_240879_4 - - - - 0.000000000000000000000000000000005893 138.0
XH2_k127_240879_5 - - - - 0.00000000000000008395 81.0
XH2_k127_2486879_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0 1032.0
XH2_k127_249858_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 461.0
XH2_k127_249858_1 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005545 371.0
XH2_k127_249858_10 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000000000000000000000002266 232.0
XH2_k127_249858_11 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000000000000000000000000000000000002124 223.0
XH2_k127_249858_12 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000001572 216.0
XH2_k127_249858_13 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000000006927 192.0
XH2_k127_249858_14 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000000000000000000000000002643 188.0
XH2_k127_249858_15 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.000000000000000000000000000000000000000005834 156.0
XH2_k127_249858_16 PFAM Ribosomal protein K02912 - - 0.00000000000000000000000000000000000000003411 155.0
XH2_k127_249858_17 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000006403 148.0
XH2_k127_249858_18 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.00000000000000000000000002594 110.0
XH2_k127_249858_19 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.0000000000000000000000003117 105.0
XH2_k127_249858_2 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 363.0
XH2_k127_249858_20 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000000000481 102.0
XH2_k127_249858_3 Binds the lower part of the 30S subunit head K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 365.0
XH2_k127_249858_4 TIGRFAM ribosomal protein L30P K02907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001168 260.0
XH2_k127_249858_5 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001251 251.0
XH2_k127_249858_6 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008407 239.0
XH2_k127_249858_7 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000001119 241.0
XH2_k127_249858_8 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000002879 238.0
XH2_k127_249858_9 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000000000000000000000000000000001599 231.0
XH2_k127_2551926_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.847e-317 982.0
XH2_k127_2551926_1 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 590.0
XH2_k127_2551926_2 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 456.0
XH2_k127_2551926_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 342.0
XH2_k127_2551926_4 - - - - 0.000000000000001592 79.0
XH2_k127_2664351_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 3.545e-300 932.0
XH2_k127_2664351_1 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 1.478e-228 716.0
XH2_k127_2664351_2 PFAM aminotransferase class V - - - 8.419e-207 647.0
XH2_k127_2664351_3 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002264 277.0
XH2_k127_2664351_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000007756 229.0
XH2_k127_2664351_5 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000001308 218.0
XH2_k127_2701455_0 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006138 355.0
XH2_k127_2701455_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003758 298.0
XH2_k127_2701455_2 PFAM Amidohydrolase 2 K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000003163 229.0
XH2_k127_2701455_3 integral membrane protein - - - 0.0000000000000000000000000000008402 130.0
XH2_k127_2701455_4 transcription factor (CBF NF-Y) - - - 0.00000000000000000000004431 99.0
XH2_k127_2701651_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 3.31e-236 736.0
XH2_k127_2701651_1 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 600.0
XH2_k127_2701651_2 Protein of unknown function (DUF475) K09799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 441.0
XH2_k127_2701651_3 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009681 437.0
XH2_k127_2701651_4 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000575 217.0
XH2_k127_2732742_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 595.0
XH2_k127_2732742_1 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 512.0
XH2_k127_2732742_2 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000009117 209.0
XH2_k127_2732742_3 helicase activity K06915 - - 0.000000000000000000000000009617 115.0
XH2_k127_2746738_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 3.835e-267 838.0
XH2_k127_2746738_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 4.242e-194 617.0
XH2_k127_2746738_2 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000001739 261.0
XH2_k127_2746738_3 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000005168 250.0
XH2_k127_2746738_4 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000000000001353 154.0
XH2_k127_2746738_5 Roadblock LC7 - - - 0.000000000000000000000000003817 123.0
XH2_k127_2746738_6 Roadblock LC7 K07131 - - 0.000000983 56.0
XH2_k127_2746738_7 Histidine kinase - - - 0.00004961 52.0
XH2_k127_2753786_0 transferase activity, transferring glycosyl groups K01365,K14475 - 3.4.22.15 0.00000000000000000000000000000000000000000000000000000000005687 215.0
XH2_k127_2753786_1 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000009047 168.0
XH2_k127_2753786_2 serine-type aminopeptidase activity K02030,K14475 - - 0.0000000000000000000000004881 108.0
XH2_k127_2779887_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 464.0
XH2_k127_2779887_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 326.0
XH2_k127_2779887_2 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000248 234.0
XH2_k127_2779887_3 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000002066 112.0
XH2_k127_2779887_4 structural constituent of ribosome K02962 - - 0.00000000000000000005934 90.0
XH2_k127_2783497_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.489e-226 709.0
XH2_k127_2783497_1 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 323.0
XH2_k127_2783497_2 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001693 279.0
XH2_k127_2783497_3 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000002344 261.0
XH2_k127_2783497_4 PFAM regulatory protein, ArsR K07721 - - 0.00000000000000000000000000000000000000000000000000000000000001953 220.0
XH2_k127_2783497_5 PFAM thymidylate kinase K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000001214 165.0
XH2_k127_2783497_6 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000002106 119.0
XH2_k127_2788350_0 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 568.0
XH2_k127_2788350_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 501.0
XH2_k127_2788350_2 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000001334 177.0
XH2_k127_2803943_0 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.000000000000000000000000000000000000000000001473 177.0
XH2_k127_2803943_1 Peptidase C39 family K06992 - - 0.000000000000000000000000000000001951 143.0
XH2_k127_2803943_2 SpoVT / AbrB like domain - - - 0.0000000000000000000000000005583 115.0
XH2_k127_2803943_3 - - - - 0.0000000000000000000000001184 112.0
XH2_k127_2839164_0 Phosphate transport regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004594 453.0
XH2_k127_2839164_1 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000002371 109.0
XH2_k127_2858880_0 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.00000000000000000000002324 99.0
XH2_k127_2858880_1 PFAM metallophosphoesterase - - - 0.00000000000000001999 93.0
XH2_k127_2879094_0 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008792 436.0
XH2_k127_2879094_1 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 387.0
XH2_k127_2879094_2 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 374.0
XH2_k127_2879094_3 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 335.0
XH2_k127_2879094_4 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000004495 170.0
XH2_k127_2879094_5 - - - - 0.00000000000000000000000000000009827 129.0
XH2_k127_2879094_6 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000001271 74.0
XH2_k127_2879094_7 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000003351 74.0
XH2_k127_2883533_0 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 373.0
XH2_k127_2883533_1 FeoA K03709 - - 0.000000000000000000000000000000000000000000000000000001834 193.0
XH2_k127_2883533_2 Protein of unknown function (DUF357) K09728 - - 0.000000000000000000000000000000000000000000001679 171.0
XH2_k127_2891295_0 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 297.0
XH2_k127_2891295_1 - - - - 0.0000000000000000000000000003708 119.0
XH2_k127_2907511_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 1.726e-200 631.0
XH2_k127_2907511_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 469.0
XH2_k127_2907511_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 343.0
XH2_k127_3062187_0 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005129 345.0
XH2_k127_3062187_1 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000003271 217.0
XH2_k127_3064050_0 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009458 268.0
XH2_k127_3064050_1 SMART Elongator protein 3 MiaB NifB - - - 0.00004328 51.0
XH2_k127_3163507_0 AMP-binding enzyme - - - 3.137e-217 682.0
XH2_k127_3163507_1 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 603.0
XH2_k127_3163507_10 Integral membrane protein DUF106 - - - 0.0000000000000000000000000000000000000000000000000000000000000002114 226.0
XH2_k127_3163507_11 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000009263 219.0
XH2_k127_3163507_12 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000106 166.0
XH2_k127_3163507_13 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000000000000000003139 93.0
XH2_k127_3163507_14 PBS lyase HEAT-like repeat - - - 0.000000000000006584 81.0
XH2_k127_3163507_15 - - - - 0.0006171 45.0
XH2_k127_3163507_2 PFAM Radical SAM domain protein K06871 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008284 607.0
XH2_k127_3163507_3 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 404.0
XH2_k127_3163507_4 Uncharacterised conserved protein (DUF2156) K01163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004483 356.0
XH2_k127_3163507_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001484 284.0
XH2_k127_3163507_6 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000004899 263.0
XH2_k127_3163507_7 Oxidoreductase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001954 257.0
XH2_k127_3163507_8 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001059 248.0
XH2_k127_3163507_9 UPF0056 membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000006264 233.0
XH2_k127_3170286_0 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009551 548.0
XH2_k127_3170286_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 310.0
XH2_k127_3170286_2 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 303.0
XH2_k127_3170286_3 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.00000000000000000000002968 101.0
XH2_k127_3223212_0 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000001562 252.0
XH2_k127_3223212_1 - - - - 0.0000000000000000000000000000001079 126.0
XH2_k127_3223212_2 protein conserved in archaea - - - 0.0000000000000000000000000000002052 125.0
XH2_k127_3223212_3 - - - - 0.0000000000000004405 79.0
XH2_k127_3288505_0 phosphoesterase RecJ domain protein - - - 5.487e-195 620.0
XH2_k127_3288505_1 Ion channel - - - 0.00000000000000000000000982 104.0
XH2_k127_3413743_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 555.0
XH2_k127_3413743_1 signal transduction protein with CBS domains K07744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 413.0
XH2_k127_3413743_2 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000001301 237.0
XH2_k127_3413743_3 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000003794 166.0
XH2_k127_3413743_4 TIGRFAM small GTP-binding protein K06943 - - 0.000000000000000000000000000000000000002059 149.0
XH2_k127_3435512_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 589.0
XH2_k127_3435512_1 Domain of unknown function (DUF4389) - - - 0.000000000000000000000000000000000005733 138.0
XH2_k127_3480407_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006676 451.0
XH2_k127_3480407_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 373.0
XH2_k127_3480407_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000001175 137.0
XH2_k127_3481354_0 in RNase L inhibitor, RLI K06174 - - 1.907e-300 929.0
XH2_k127_3481354_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000000000000000003758 183.0
XH2_k127_3481354_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000001003 165.0
XH2_k127_3550578_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007397 560.0
XH2_k127_3550578_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 472.0
XH2_k127_3550578_2 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 345.0
XH2_k127_3550578_3 Uncharacterised protein family UPF0058 - - - 0.00000000000000000000000000000000000000006707 152.0
XH2_k127_3550578_4 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000001643 100.0
XH2_k127_3550578_5 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.00000000000000001245 85.0
XH2_k127_3574733_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 407.0
XH2_k127_3574733_1 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 358.0
XH2_k127_3574733_2 Bacterial Ig-like domain 2 - - - 0.0000000000000000001358 103.0
XH2_k127_3593176_0 PFAM PilT protein domain protein K06865 - - 3.074e-304 942.0
XH2_k127_3593176_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 1.855e-265 823.0
XH2_k127_3593176_2 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.000000000000000000000000000000000000000000000000000000000000000000000000003637 261.0
XH2_k127_3593176_3 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000000009868 187.0
XH2_k127_359605_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009136 469.0
XH2_k127_359605_1 PFAM ABC transporter related K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 419.0
XH2_k127_359605_2 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 385.0
XH2_k127_359605_3 amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002987 229.0
XH2_k127_359605_4 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000001557 166.0
XH2_k127_359605_5 - - - - 0.0000000000000000000000000000000000000474 151.0
XH2_k127_359605_6 methanogenesis marker protein 11 - - - 0.00000000000000000000000001581 111.0
XH2_k127_3674507_0 Met-10+ like-protein K15429 - 2.1.1.228 0.000000000000000000000000000000000000004264 149.0
XH2_k127_3674507_1 Putative auto-transporter adhesin, head GIN domain - - - 0.0000000000000000003045 98.0
XH2_k127_3674507_2 amino acid K03294 - - 0.00000000000001141 75.0
XH2_k127_3684217_0 Replication factor C K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006254 353.0
XH2_k127_3684217_1 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005358 311.0
XH2_k127_3684217_2 PFAM AIR synthase related protein K07388 - - 0.00000000000000000000000000000000000006367 146.0
XH2_k127_368907_0 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 1.425e-246 779.0
XH2_k127_368907_1 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 446.0
XH2_k127_368907_10 TPR repeat-containing protein - - - 0.000003484 53.0
XH2_k127_368907_11 luxR family - - - 0.0008302 46.0
XH2_k127_368907_2 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 383.0
XH2_k127_368907_3 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 359.0
XH2_k127_368907_4 FHA domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 293.0
XH2_k127_368907_5 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008091 302.0
XH2_k127_368907_6 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.00000000000000000000000000000000000000000000000000000000000000000001169 237.0
XH2_k127_368907_7 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000003523 223.0
XH2_k127_368907_8 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000002624 206.0
XH2_k127_368907_9 Endonuclease V K05982 - 3.1.21.7 0.0000000000000000000000000000000000000000000006867 174.0
XH2_k127_3691185_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1838.0
XH2_k127_3691185_1 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006586 272.0
XH2_k127_3691185_2 Protein of unknown function (DUF432) K09149 - - 0.000000000000000000000000000000000000000000000000000000001471 208.0
XH2_k127_3691185_3 Radical SAM ThiC family K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000002766 186.0
XH2_k127_3691185_4 - - - - 0.000000000000000000000000000000000003111 143.0
XH2_k127_3691185_5 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000001321 70.0
XH2_k127_3718636_0 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008426 346.0
XH2_k127_3718636_1 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000005029 208.0
XH2_k127_377326_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 2.188e-201 633.0
XH2_k127_377326_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 483.0
XH2_k127_377326_10 PFAM peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001194 249.0
XH2_k127_377326_11 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000002652 195.0
XH2_k127_377326_12 Helix-turn-helix domain protein K03627 - - 0.0000000000000000000000000000000000000000000000002134 182.0
XH2_k127_377326_2 domain, Protein K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 464.0
XH2_k127_377326_3 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645,K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006911 444.0
XH2_k127_377326_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 453.0
XH2_k127_377326_5 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 439.0
XH2_k127_377326_6 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 442.0
XH2_k127_377326_7 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000805 410.0
XH2_k127_377326_8 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 313.0
XH2_k127_377326_9 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006891 302.0
XH2_k127_3834206_0 Tripartite tricarboxylate transporter TctA family K08971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 409.0
XH2_k127_3834206_1 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000001472 190.0
XH2_k127_3834206_2 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.0000000000000000000000000000000000000000000005552 172.0
XH2_k127_385601_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006421 302.0
XH2_k127_385601_1 Belongs to the UPF0305 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000005744 233.0
XH2_k127_385601_2 Phosphate-starvation-inducible E - - - 0.000000000000000000000000001412 117.0
XH2_k127_3990077_0 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 384.0
XH2_k127_3990077_1 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000005629 232.0
XH2_k127_3990077_2 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000004621 128.0
XH2_k127_4009626_0 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 584.0
XH2_k127_4009626_1 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 407.0
XH2_k127_4155103_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 3.713e-234 731.0
XH2_k127_4155103_1 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 515.0
XH2_k127_4155103_10 - - - - 0.0000000000000000000000006594 110.0
XH2_k127_4155103_11 nucleic acid binding OB-fold tRNA helicase-type - - - 0.0000000000000000000000044 106.0
XH2_k127_4155103_2 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 440.0
XH2_k127_4155103_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 387.0
XH2_k127_4155103_4 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 355.0
XH2_k127_4155103_5 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 312.0
XH2_k127_4155103_6 - - - - 0.0000000000000000000000000000000000000000000000000000000003656 209.0
XH2_k127_4155103_7 PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000000000000000003184 171.0
XH2_k127_4155103_8 Transcriptional regulator K07108 - - 0.0000000000000000000000000000001503 126.0
XH2_k127_4155103_9 transcriptional regulators K03724 - - 0.0000000000000000000000000002799 115.0
XH2_k127_4185780_0 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 343.0
XH2_k127_4185780_1 cytidyltransferase-related domain K00952 - 2.7.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000362 262.0
XH2_k127_4185780_2 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000001957 166.0
XH2_k127_4185780_3 - - - - 0.00000000000000000000000000000000003706 137.0
XH2_k127_4185780_4 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000000000000000000009811 128.0
XH2_k127_4185780_5 - - - - 0.00000000000000000000000001479 110.0
XH2_k127_4185780_6 - - - - 0.000000000000000000003003 97.0
XH2_k127_4185780_7 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000265 93.0
XH2_k127_4223908_0 PFAM ferredoxin-dependent glutamate synthase - - - 1.815e-295 912.0
XH2_k127_4223908_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 440.0
XH2_k127_4223908_2 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 426.0
XH2_k127_4223908_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000000002583 135.0
XH2_k127_4264841_0 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 469.0
XH2_k127_4264841_1 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000001383 149.0
XH2_k127_4264841_2 Tetratricopeptide repeat - - - 0.00000000000000000000000004615 120.0
XH2_k127_4291482_0 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 436.0
XH2_k127_4291482_1 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 381.0
XH2_k127_4291482_2 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006121 276.0
XH2_k127_4291482_3 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000000000000000000000000000000000000000000000000000000000009473 229.0
XH2_k127_4291482_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000005581 181.0
XH2_k127_4291482_5 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000005402 152.0
XH2_k127_4291482_6 - - - - 0.000000000000000000000001604 108.0
XH2_k127_4362340_0 PFAM peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008988 392.0
XH2_k127_4362340_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 303.0
XH2_k127_4362340_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006324 246.0
XH2_k127_4385546_0 permease K03299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 390.0
XH2_k127_4385546_1 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000005554 175.0
XH2_k127_4385546_2 Nitroreductase - - - 0.00000003861 56.0
XH2_k127_4448337_0 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 428.0
XH2_k127_4448337_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000001349 267.0
XH2_k127_4448337_2 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000004357 216.0
XH2_k127_4448337_3 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.00000000000000000000000000000001616 128.0
XH2_k127_4515811_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.925e-233 729.0
XH2_k127_4515811_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 358.0
XH2_k127_4515811_2 binds to the 23S rRNA K02921 - - 0.0000000000000000000000000000000000000000252 154.0
XH2_k127_4515811_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.0000000000000000000000000000000000000008352 154.0
XH2_k127_4515811_4 Probably involved in the biogenesis of the ribosome K14561 - - 0.000000000000000000008013 98.0
XH2_k127_4515811_5 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000003204 91.0
XH2_k127_4515811_6 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000005004 89.0
XH2_k127_4515811_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000001512 91.0
XH2_k127_4583640_0 Domain of unknown function (DUF3821) - - - 6.175e-254 809.0
XH2_k127_4583640_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000244 141.0
XH2_k127_4606671_0 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009958 599.0
XH2_k127_4606671_1 PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit K18017 - 1.12.7.2 0.00000000000000000000000000000000000000000000000000000000005107 211.0
XH2_k127_4606671_2 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K18023 - 1.12.7.2 0.0000000008337 59.0
XH2_k127_4623289_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 5.953e-278 872.0
XH2_k127_4623289_1 protein conserved in archaea - - - 0.000000000000000000000000007183 125.0
XH2_k127_4671731_0 Domain of unknown function (DUF1848) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 369.0
XH2_k127_4671731_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 349.0
XH2_k127_4750252_0 PFAM PP-loop domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 384.0
XH2_k127_4750252_1 Rio2, N-terminal K07179 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 383.0
XH2_k127_4750252_2 Protein of unknown function (DUF460) K09150 - - 0.0000000000000000000000000000000000000000000000000000002122 199.0
XH2_k127_4750252_3 PFAM TrkA-N domain protein K10716 - - 0.000000000000000000000000000000000000000000000003161 181.0
XH2_k127_4807122_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 8.756e-201 635.0
XH2_k127_4807122_1 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 315.0
XH2_k127_4807122_2 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000000000007015 156.0
XH2_k127_4807122_3 PFAM PUA domain containing protein K07398 - - 0.000000000000000000000000000000000000002742 151.0
XH2_k127_4807122_4 PhoD-like phosphatase K01113 - 3.1.3.1 0.0005135 50.0
XH2_k127_4871937_0 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006651 315.0
XH2_k127_4871937_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 313.0
XH2_k127_4871937_2 Helix-turn-helix domain protein K07731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 282.0
XH2_k127_4915436_0 ATP-grasp domain K06913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008291 336.0
XH2_k127_4915436_1 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001437 247.0
XH2_k127_4915436_2 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.0000000000000000000000000000000000000000000008268 170.0
XH2_k127_4915436_3 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.0000000000003424 70.0
XH2_k127_4924923_0 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 449.0
XH2_k127_4924923_1 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002351 377.0
XH2_k127_4924923_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002231 269.0
XH2_k127_4924923_3 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000001916 216.0
XH2_k127_4924923_4 - - - - 0.00000000000000000001099 92.0
XH2_k127_4924923_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.00000001131 56.0
XH2_k127_4966121_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0 1268.0
XH2_k127_4966121_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 7.919e-212 667.0
XH2_k127_4966121_2 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 419.0
XH2_k127_4966121_3 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 334.0
XH2_k127_4966121_4 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000000000000000000000000000000000000000000000004014 193.0
XH2_k127_4966121_5 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000002063 135.0
XH2_k127_4966121_6 Protein of unknown function DUF86 K07075 - - 0.00000000000000000000009675 106.0
XH2_k127_5049349_0 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008739 598.0
XH2_k127_5049349_1 Belongs to the UPF0280 family K09740 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009952 269.0
XH2_k127_5049349_2 PFAM Metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000001386 243.0
XH2_k127_5049349_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000002625 183.0
XH2_k127_5049349_4 - - - - 0.00000000000000000000000000001916 122.0
XH2_k127_5049349_5 - - - - 0.00000000000000001251 85.0
XH2_k127_5087078_0 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005281 587.0
XH2_k127_5087078_1 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 457.0
XH2_k127_5087078_2 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 326.0
XH2_k127_5087078_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001232 248.0
XH2_k127_5087078_4 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000007517 181.0
XH2_k127_5115342_0 RimK-like ATPgrasp N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007259 226.0
XH2_k127_5115342_1 - - - - 0.00000000000000000000000000000000000000000000005117 184.0
XH2_k127_5115342_2 Thioredoxin - - - 0.000000000000000000000000000000007296 130.0
XH2_k127_5146245_0 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 440.0
XH2_k127_5146245_1 Zinc-uptake complex component A periplasmic K09815 - - 0.0000000000000000000000000000000000000000000000000000000000003773 221.0
XH2_k127_5146245_2 ATPases associated with a variety of cellular activities K09817 - - 0.000000000000000000000000000000000000000000000000000000009084 204.0
XH2_k127_5146245_3 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000104 186.0
XH2_k127_5146245_4 iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000000004299 173.0
XH2_k127_5146245_5 RuvA, C-terminal domain K03550 - 3.6.4.12 0.000000000000000000000000000000000000000001507 163.0
XH2_k127_5169970_0 MafB19-like deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 308.0
XH2_k127_5169970_1 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001874 261.0
XH2_k127_5169970_2 - - - - 0.0000000000000000000000000000007066 126.0
XH2_k127_5169970_3 - - - - 0.000000000000000000000000002462 113.0
XH2_k127_5169970_4 - - - - 0.000000000000000000000000455 108.0
XH2_k127_5335483_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0 1034.0
XH2_k127_5335483_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 5.473e-278 857.0
XH2_k127_5335483_2 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 6.742e-233 738.0
XH2_k127_5335483_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 582.0
XH2_k127_5335483_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 426.0
XH2_k127_5335483_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 323.0
XH2_k127_5335483_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000000000000000000000000000000000000000008064 214.0
XH2_k127_5335483_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000009342 97.0
XH2_k127_5335483_8 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.000000000000000000002283 95.0
XH2_k127_5352733_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 1.554e-244 769.0
XH2_k127_5352733_1 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000278 228.0
XH2_k127_5352733_2 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000001084 165.0
XH2_k127_5352733_3 Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively - - - 0.0000000000000000004855 87.0
XH2_k127_5408041_0 PFAM ribonuclease II K01147 - 3.1.13.1 2.408e-215 681.0
XH2_k127_5408041_1 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.0000000000000000000004906 97.0
XH2_k127_5408041_2 - - - - 0.00000001548 62.0
XH2_k127_5421239_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 414.0
XH2_k127_5421239_1 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000009958 254.0
XH2_k127_5437409_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 406.0
XH2_k127_5437409_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 361.0
XH2_k127_5437409_2 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000004982 271.0
XH2_k127_5437409_3 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000005822 176.0
XH2_k127_5437409_4 COG0512 Anthranilate para-aminobenzoate synthases component II K01658 - 4.1.3.27 0.00000000001025 65.0
XH2_k127_5490955_0 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 541.0
XH2_k127_5490955_1 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 527.0
XH2_k127_5490955_2 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 372.0
XH2_k127_5490955_3 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009338 295.0
XH2_k127_5490955_4 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000000001819 216.0
XH2_k127_5490955_5 Dihydrouridine synthase (Dus) - - - 0.0000000000000000000000000000000000000000000000000001438 187.0
XH2_k127_5490955_6 Protein of unknown function (DUF447) K09154 - - 0.000000000000000000000000000000000000000000002518 171.0
XH2_k127_5490955_7 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000000000000000000000772 160.0
XH2_k127_5490955_8 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000000000000000000000000000000000002372 149.0
XH2_k127_5490955_9 Psort location Cytoplasmic, score 8.87 - - - 0.00002283 49.0
XH2_k127_5497009_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 1.692e-261 814.0
XH2_k127_5497009_1 PFAM TM2 domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001955 284.0
XH2_k127_5497009_2 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000309 274.0
XH2_k127_5497009_3 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000000000000000000000000000000000005053 224.0
XH2_k127_5497009_4 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000344 227.0
XH2_k127_5497009_5 Glutaredoxin - - - 0.00000000000000000000000000000000003207 136.0
XH2_k127_5497009_6 - - - - 0.0000000000000000000000000000000003873 134.0
XH2_k127_5497009_7 - - - - 0.00000000000000000000006194 101.0
XH2_k127_5497009_8 PBS lyase HEAT-like repeat - - - 0.0000000000000000000003664 100.0
XH2_k127_5525181_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 2.033e-245 769.0
XH2_k127_5525181_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 1.134e-215 678.0
XH2_k127_5525181_2 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 8.499e-202 634.0
XH2_k127_5525181_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 581.0
XH2_k127_5525181_4 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000957 391.0
XH2_k127_5525181_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006443 283.0
XH2_k127_5525181_6 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000004043 229.0
XH2_k127_5525181_7 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000001026 50.0
XH2_k127_5547925_0 PFAM glycoside hydrolase family 77 K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 474.0
XH2_k127_5547925_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000003346 175.0
XH2_k127_5547925_2 Protein of unknown function (DUF1211) - - - 0.00000000000000000000000000000000006508 142.0
XH2_k127_5559222_0 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 603.0
XH2_k127_5559222_1 COG0438 Glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000001586 231.0
XH2_k127_5559222_2 DNA polymerase LigD, polymerase domain K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000006799 212.0
XH2_k127_5559222_3 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000006486 199.0
XH2_k127_5559222_4 DNA ligase K01971 - 6.5.1.1 0.0008996 43.0
XH2_k127_5563819_0 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 456.0
XH2_k127_5563819_1 PFAM glutamate--cysteine ligase, GCS2 - - - 0.000000000000000000000000000000000000000000000000001538 187.0
XH2_k127_5563819_2 RimK-like ATPgrasp N-terminal domain - - - 0.000000000000000000000000000001313 123.0
XH2_k127_5585192_0 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006439 343.0
XH2_k127_5585192_1 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000001902 210.0
XH2_k127_5585192_2 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.00000000000000000000000000001398 128.0
XH2_k127_5585192_3 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000002236 92.0
XH2_k127_5593031_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 8.045e-298 924.0
XH2_k127_5593031_1 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 358.0
XH2_k127_5593031_2 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008768 319.0
XH2_k127_5593031_3 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000003904 252.0
XH2_k127_5593031_4 PFAM TspO MBR family K05770 - - 0.00000000000000000000000000000000000000000000001207 175.0
XH2_k127_5593031_5 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000001328 167.0
XH2_k127_5606710_0 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 345.0
XH2_k127_5606710_1 Protein-export membrane protein SecD K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 321.0
XH2_k127_5606710_2 PFAM Thioredoxin K03671 - - 0.00000000000000000000000000000000000000000000008905 169.0
XH2_k127_5606710_3 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.00000000000000000000000000000000000008543 143.0
XH2_k127_5609141_0 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 447.0
XH2_k127_5609141_1 PFAM ABC transporter related K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 393.0
XH2_k127_5609141_2 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 367.0
XH2_k127_5609141_3 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 284.0
XH2_k127_5609141_4 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.0000000000000000000000000000002417 127.0
XH2_k127_561250_0 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 563.0
XH2_k127_561250_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 415.0
XH2_k127_5621017_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 2.909e-198 622.0
XH2_k127_5621017_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 438.0
XH2_k127_5621017_10 - - - - 0.0000000000000000007523 87.0
XH2_k127_5621017_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007135 416.0
XH2_k127_5621017_3 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 344.0
XH2_k127_5621017_4 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 317.0
XH2_k127_5621017_5 Transcription elongation factor Spt5 K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001979 258.0
XH2_k127_5621017_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007613 254.0
XH2_k127_5621017_7 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.00000000000000000000000000000004846 127.0
XH2_k127_5621017_8 PFAM peptidase zinc-dependent K06974 - - 0.0000000000000000000000000001425 117.0
XH2_k127_5621017_9 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.00000000000000000002074 91.0
XH2_k127_5635757_0 Reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 420.0
XH2_k127_5635757_1 PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 391.0
XH2_k127_5635757_2 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009645 321.0
XH2_k127_5635757_3 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) - - - 0.00000000000000000000000000000000000000000000000000000002469 199.0
XH2_k127_5635757_4 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000004974 182.0
XH2_k127_5635757_5 Sodium Bile acid symporter family - - - 0.00000000000000000000000000000000000000000003806 172.0
XH2_k127_5635757_6 - - - - 0.0000000000000000000000000000000000000000001609 166.0
XH2_k127_5635757_7 Hydrogenase maturation protease K08315 - 3.4.23.51 0.000000000000000000000000000000000000003167 151.0
XH2_k127_5635757_8 PFAM regulatory protein, ArsR K21903 - - 0.000000000000000000000000004573 115.0
XH2_k127_5635757_9 META domain - - - 0.00000000000000000001266 102.0
XH2_k127_5688898_0 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005579 571.0
XH2_k127_5688898_1 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008777 535.0
XH2_k127_5688898_2 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 480.0
XH2_k127_5688898_3 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000008102 234.0
XH2_k127_5688898_4 - - - - 0.0000000000000000000000000000000000244 141.0
XH2_k127_5701855_0 PFAM elongation factor Tu domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 370.0
XH2_k127_5701855_1 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 373.0
XH2_k127_5701855_2 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 338.0
XH2_k127_5701855_3 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001023 244.0
XH2_k127_5714799_0 PFAM AAA ATPase central domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 556.0
XH2_k127_5714799_1 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 380.0
XH2_k127_5714799_2 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008665 332.0
XH2_k127_5714799_3 PFAM peptidase M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 321.0
XH2_k127_5714799_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000008697 50.0
XH2_k127_5729567_0 PFAM Radical SAM domain protein K07129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009589 538.0
XH2_k127_5729567_1 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 414.0
XH2_k127_5729567_2 Phage plasmid primase, P4 K06919 - - 0.0000000000000000000000000000000001586 139.0
XH2_k127_5749821_0 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 368.0
XH2_k127_5749821_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 335.0
XH2_k127_5749821_2 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000001452 115.0
XH2_k127_5749821_3 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000006031 66.0
XH2_k127_5749821_4 Uncharacterised ArCR, COG2043 - - - 0.00000000001938 64.0
XH2_k127_5751877_0 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 377.0
XH2_k127_5751877_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000633 212.0
XH2_k127_5751877_2 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.00000000000000000000000000000000000000000000004953 172.0
XH2_k127_5770370_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 572.0
XH2_k127_5770370_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004134 421.0
XH2_k127_5770370_2 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005942 307.0
XH2_k127_5770370_3 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005223 292.0
XH2_k127_5770370_4 PFAM Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000000109 195.0
XH2_k127_5770370_5 - K06868 - 2.5.1.73 0.0000000000005062 70.0
XH2_k127_5834998_0 PFAM Aminotransferase class I and II K10907 - - 4.613e-194 610.0
XH2_k127_5834998_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005134 556.0
XH2_k127_5834998_2 PFAM regulatory protein AsnC Lrp family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001351 242.0
XH2_k127_5834998_3 Trm112p-like protein - - - 0.000000000000000008586 86.0
XH2_k127_5882489_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 1.591e-212 668.0
XH2_k127_5882489_1 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 467.0
XH2_k127_5882489_2 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000001801 147.0
XH2_k127_5899175_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 291.0
XH2_k127_5899175_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008501 281.0
XH2_k127_5899175_2 Domain of unknown function (DUF389) - - - 0.0000000000000000000000000000000000000000000000000001115 192.0
XH2_k127_5899175_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000005102 171.0
XH2_k127_5933831_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 5.714e-280 869.0
XH2_k127_5933831_1 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 5.805e-262 812.0
XH2_k127_5933831_2 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009385 499.0
XH2_k127_5933831_3 PFAM ABC transporter K16786 - - 0.000000000000000000000000000000000000000000000000000000000006138 214.0
XH2_k127_5933831_4 PFAM ABC transporter related K02068,K03529,K06166,K16786,K16787 - 2.7.8.37 0.00000000000000000000000000000000000000000000000000000004171 204.0
XH2_k127_5933831_5 PFAM BioY protein K03523 - - 0.0000000000000000000000000000000000000000000000000007339 188.0
XH2_k127_5933831_6 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.0000000000000000008298 85.0
XH2_k127_5949452_0 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 305.0
XH2_k127_5949452_1 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000002994 216.0
XH2_k127_5949452_2 PFAM Thioredoxin K03671 - - 0.00000000000000000000000000000000008283 135.0
XH2_k127_5964439_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 0.0 1130.0
XH2_k127_5964439_1 Putative NAD(P)-binding K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009352 274.0
XH2_k127_5964439_2 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000007675 219.0
XH2_k127_5964439_3 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000004049 212.0
XH2_k127_5964439_4 TIR domain - - - 0.00000000000000000005422 98.0
XH2_k127_5964439_5 - - - - 0.00025 45.0
XH2_k127_597975_0 - - - - 0.0000000000000000000000000000000000000000000000007972 185.0
XH2_k127_597975_1 Thiopurine S-methyltransferase (TPMT) - - - 0.000000000000000000000000000000000000000000000002114 177.0
XH2_k127_597975_2 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000008044 159.0
XH2_k127_5980852_0 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005918 445.0
XH2_k127_5980852_1 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 418.0
XH2_k127_5980852_2 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 340.0
XH2_k127_5980852_3 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002164 279.0
XH2_k127_5980852_4 - - - - 0.0000000000000000000000000000000000000001318 154.0
XH2_k127_5980852_5 PDGLE domain K02009 - - 0.00000000000000000004299 102.0
XH2_k127_5986784_0 LOR SDH bifunctional enzyme conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009917 522.0
XH2_k127_5986784_1 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006583 312.0
XH2_k127_5986784_2 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000000000000000001303 231.0
XH2_k127_6151582_0 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 411.0
XH2_k127_6151582_1 Regulatory protein MarR - - - 0.000000000000000000000001688 109.0
XH2_k127_6151582_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000008603 70.0
XH2_k127_6151582_3 PBS lyase HEAT-like repeat - - - 0.0000000004524 64.0
XH2_k127_6167013_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1603.0
XH2_k127_6167013_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1074.0
XH2_k127_6167013_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 5.41e-202 633.0
XH2_k127_6167013_3 transcription termination protein NusA K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003614 243.0
XH2_k127_6167013_4 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.0000000000000000000000000000000000000000005386 157.0
XH2_k127_6167013_5 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.000000000000000000000000000000000000000006141 157.0
XH2_k127_6167013_6 Protein of unknown function (DUF473) K09135 - - 0.00000000000000000000000000000006063 127.0
XH2_k127_6217139_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 7.293e-286 886.0
XH2_k127_6217139_1 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 471.0
XH2_k127_6217139_2 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004839 363.0
XH2_k127_6217139_3 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 305.0
XH2_k127_6217139_4 - - - - 0.000000000000000000000001136 103.0
XH2_k127_6221715_0 transcriptional regulator, ArsR family K07013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003573 245.0
XH2_k127_6221715_1 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.00000000000000000000000000000000001649 142.0
XH2_k127_6221715_2 PFAM Archaeal protein of - - - 0.00000000000000000000000003902 110.0
XH2_k127_6265764_0 AAA-like domain K06915 - - 8.013e-235 737.0
XH2_k127_6265764_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.000000000000000000000000000000000000000000000000000000002735 203.0
XH2_k127_629322_0 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005429 296.0
XH2_k127_629322_1 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000147 255.0
XH2_k127_629322_2 Anaerobic ribonucleoside-triphosphate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000005008 223.0
XH2_k127_629322_3 Cysteine-rich small domain K08260 - 3.5.1.90 0.0000000000000000000000000006938 115.0
XH2_k127_6370218_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 581.0
XH2_k127_6370218_1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008777 475.0
XH2_k127_6370218_2 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009168 327.0
XH2_k127_6370218_3 Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000001106 230.0
XH2_k127_6566493_0 PFAM AIR synthase related protein K07123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 499.0
XH2_k127_6566493_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 323.0
XH2_k127_6566493_2 methanogen marker protein 4 - - - 0.0000000000000000000000000003637 117.0
XH2_k127_6691916_0 in RNase L inhibitor, RLI K06174 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 556.0
XH2_k127_6691916_1 Domain of unknown function (DUF814) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007746 527.0
XH2_k127_6691916_2 RNase L inhibitor, RLI - - - 0.0000000000000000000000005746 110.0
XH2_k127_6699699_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 394.0
XH2_k127_6699699_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000863 262.0
XH2_k127_6699699_2 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000009922 159.0
XH2_k127_6699699_3 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000003985 113.0
XH2_k127_6699699_4 - - - - 0.000000000000000000000006686 103.0
XH2_k127_6741166_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 606.0
XH2_k127_6741166_1 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 325.0
XH2_k127_6741166_2 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.000000000000000000000000000000000000002655 147.0
XH2_k127_6741166_3 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000008132 120.0
XH2_k127_6751352_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 1.517e-215 675.0
XH2_k127_6751352_1 methanogenesis marker protein 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 481.0
XH2_k127_6751352_2 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 315.0
XH2_k127_6751352_3 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000363 241.0
XH2_k127_6751352_4 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.00000000000000000000000000000000000000000000000000000000000000001197 229.0
XH2_k127_6751352_5 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.00000000000000000000000000000000000000000000000000000000000002025 217.0
XH2_k127_6751352_6 - - - - 0.0000000002417 68.0
XH2_k127_6755463_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003902 510.0
XH2_k127_6755463_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 494.0
XH2_k127_6755463_2 serine threonine protein kinase K07178 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 346.0
XH2_k127_6755463_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000005336 100.0
XH2_k127_6800723_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 1.907e-230 719.0
XH2_k127_6800723_1 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 549.0
XH2_k127_6800723_10 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.000000000000000000000000000000000000000000000004381 173.0
XH2_k127_6800723_11 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.00000000000000000000000000000000000000000000001207 175.0
XH2_k127_6800723_12 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000000000000000000003264 160.0
XH2_k127_6800723_13 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000000000000000000002941 154.0
XH2_k127_6800723_14 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.000000000000000000000000000000000007049 138.0
XH2_k127_6800723_15 PFAM Ribosomal LX protein K02944 - - 0.000000000000000001726 86.0
XH2_k127_6800723_16 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000004048 84.0
XH2_k127_6800723_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 472.0
XH2_k127_6800723_3 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 347.0
XH2_k127_6800723_4 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003543 297.0
XH2_k127_6800723_5 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001703 280.0
XH2_k127_6800723_6 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000000000000000000000000000004394 248.0
XH2_k127_6800723_7 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.000000000000000000000000000000000000000000000000000000000000000002803 231.0
XH2_k127_6800723_8 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.000000000000000000000000000000000000000000000000000000000000001764 220.0
XH2_k127_6800723_9 PFAM methyltransferase small K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000001561 211.0
XH2_k127_6819132_0 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 596.0
XH2_k127_6819132_1 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007342 417.0
XH2_k127_6819132_2 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000000000000000000000000000006069 233.0
XH2_k127_6819132_3 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000002091 142.0
XH2_k127_6819132_4 - - - - 0.00000000000005977 74.0
XH2_k127_6859532_0 PFAM phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 310.0
XH2_k127_6859532_2 Flavodoxin - - - 0.0000000000000000000000000005303 121.0
XH2_k127_6859532_3 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000000005529 114.0
XH2_k127_6873661_0 PFAM SufBD protein K07033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 577.0
XH2_k127_6873661_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001328 282.0
XH2_k127_6873661_2 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000002045 237.0
XH2_k127_6873661_3 PFAM cyclase family protein K07130 - 3.5.1.9 0.00000000000000000000001933 101.0
XH2_k127_6925402_0 Polyphosphate kinase 2 (PPK2) - - - 2.145e-195 620.0
XH2_k127_6925402_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000111 118.0
XH2_k127_6925402_2 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity - - - 0.000002041 51.0
XH2_k127_6987748_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 5.96e-278 869.0
XH2_k127_6987748_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007657 289.0
XH2_k127_6998303_0 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 498.0
XH2_k127_6998303_1 Binding-protein-dependent transport system inner membrane component K05773 - - 0.000000000000000000000000000000000000000000006124 165.0
XH2_k127_6998303_2 beta-lactamase domain protein - - - 0.000000000000000000000000000005042 121.0
XH2_k127_7076269_0 PFAM UbiA prenyltransferase K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000001234 206.0
XH2_k127_7076269_1 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000000000000000000000000000000000000000000001325 179.0
XH2_k127_7076269_2 Methyltransferase K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000665 168.0
XH2_k127_7076269_3 - - - - 0.000000000000000000000000000000000000002029 154.0
XH2_k127_7076269_4 Uncharacterized protein family, UPF0114 - - - 0.00000000000000000001579 98.0
XH2_k127_7076269_5 - - - - 0.000000000000003073 86.0
XH2_k127_7076269_6 Short repeat of unknown function (DUF308) - - - 0.0002304 51.0
XH2_k127_7095039_0 SMART Elongator protein 3 MiaB NifB - - - 5.863e-261 817.0
XH2_k127_7095039_1 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001141 253.0
XH2_k127_7095039_2 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.0000000000000000000000000000000000000000000000000000000000192 210.0
XH2_k127_7095039_3 Domain of unknown function (DUF296) K06934 - - 0.000000000000000000000000000000000000000000000005932 176.0
XH2_k127_7154563_0 TIGRFAM TraB family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 507.0
XH2_k127_7154563_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000007256 195.0
XH2_k127_7154563_2 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000000004896 175.0
XH2_k127_7154563_3 PFAM metallophosphoesterase - - - 0.0000000000000000000000000000000000001401 149.0
XH2_k127_7310857_0 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005917 506.0
XH2_k127_7310857_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000005695 201.0
XH2_k127_7310857_2 PFAM HhH-GPD family protein K03575 - - 0.0000000000000000000000000000002052 125.0
XH2_k127_7385535_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 6.426e-208 662.0
XH2_k127_7385535_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009853 526.0
XH2_k127_7385535_2 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 435.0
XH2_k127_7385535_3 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 363.0
XH2_k127_7385535_4 PFAM GTP-binding protein HSR1-related K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 344.0
XH2_k127_7385535_5 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002422 266.0
XH2_k127_7385535_6 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000031 258.0
XH2_k127_7385535_7 Belongs to the SUI1 family K03113 - - 0.00000000000000000000000000000000000000000000000000000005487 196.0
XH2_k127_7385535_8 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.000000000000000000000000000000000000000000001576 167.0
XH2_k127_7385535_9 Zn-ribbon containing protein K07163 - - 0.00000000000000000000000001446 113.0
XH2_k127_7394811_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 5.092e-271 844.0
XH2_k127_7394811_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000005432 218.0
XH2_k127_7394811_2 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000002559 87.0
XH2_k127_7547992_0 PFAM Glucose-methanol-choline oxidoreductase, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007419 378.0
XH2_k127_7547992_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 335.0
XH2_k127_7547992_2 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000000000000001022 171.0
XH2_k127_7547992_3 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000007873 120.0
XH2_k127_7550537_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 3.447e-292 945.0
XH2_k127_7550537_1 Highly conserved protein containing a thioredoxin domain K06888 - - 5.001e-211 677.0
XH2_k127_7550537_2 Rhodanese-like domain K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 522.0
XH2_k127_7550537_3 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000671 276.0
XH2_k127_7550537_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000005513 203.0
XH2_k127_7675387_0 PHP C-terminal domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 464.0
XH2_k127_7675387_1 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 321.0
XH2_k127_7675387_2 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 288.0
XH2_k127_7675387_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000003215 100.0
XH2_k127_7722841_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007814 546.0
XH2_k127_7722841_1 Belongs to the UPF0285 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009345 244.0
XH2_k127_7722841_2 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000001362 89.0
XH2_k127_7722841_3 helicase activity K06915 - - 0.00000000003329 65.0
XH2_k127_7741087_0 acid binding OB-fold tRNA helicase-type K07463 - - 2.887e-315 974.0
XH2_k127_7741087_1 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 347.0
XH2_k127_7741087_2 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000008578 177.0
XH2_k127_7741087_3 - - - - 0.000000000000000000000000000000000005417 137.0
XH2_k127_7741087_4 - - - - 0.000000000000000000000003942 102.0
XH2_k127_7741087_5 PFAM Yip1 domain - - - 0.00000000000000000001299 99.0
XH2_k127_7741087_6 PFAM TfuA domain protein, core - - - 0.00000000003123 66.0
XH2_k127_7770398_0 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006138 510.0
XH2_k127_7770398_1 COG1194 A G-specific DNA glycosylase K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004863 290.0
XH2_k127_7770398_2 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000000000000000000000000000000000000000000000001425 221.0
XH2_k127_7770398_3 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000197 138.0
XH2_k127_8007018_0 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 513.0
XH2_k127_8007018_1 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 434.0
XH2_k127_8007018_2 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 416.0
XH2_k127_8007018_3 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000003544 264.0
XH2_k127_8007018_4 methyltransferase small K07579 - - 0.00000000000000000000000000000000000000000000000000000000000000000004427 237.0
XH2_k127_8010802_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008722 407.0
XH2_k127_8010802_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 374.0
XH2_k127_8010802_2 Domain of unknown function DUF128 K21640 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 333.0
XH2_k127_8010802_3 PFAM transcriptional regulator TrmB - - - 0.000000000000000000000000000003056 126.0
XH2_k127_8090085_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1329.0
XH2_k127_8090085_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 557.0
XH2_k127_8090085_2 DEAD DEAH box helicase domain protein K10896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 484.0
XH2_k127_8090085_3 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000001143 192.0
XH2_k127_8090085_4 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000000000000000000003891 156.0
XH2_k127_8090085_5 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.0000000000000000000000000001875 118.0
XH2_k127_8111834_0 KH, type 1, domain K07041 - - 0.0 1137.0
XH2_k127_8111834_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 312.0
XH2_k127_8111834_2 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000654 210.0
XH2_k127_8122289_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 3.588e-196 617.0
XH2_k127_8122289_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009495 550.0
XH2_k127_8122289_10 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006869 270.0
XH2_k127_8122289_11 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000008622 232.0
XH2_k127_8122289_12 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.0000000000000000000000000000000000000000000002311 168.0
XH2_k127_8122289_13 methanogen marker protein 4 - - - 0.000000000000000000000000000000000000000000005694 164.0
XH2_k127_8122289_14 transcription factor (CBF NF-Y) - - - 0.0000000000000000000000000002464 114.0
XH2_k127_8122289_15 secretion by the type IV secretion system K07332 - - 0.00000000000000000000000008393 117.0
XH2_k127_8122289_16 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0004444 48.0
XH2_k127_8122289_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 501.0
XH2_k127_8122289_3 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000882 462.0
XH2_k127_8122289_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007695 461.0
XH2_k127_8122289_5 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 412.0
XH2_k127_8122289_6 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 312.0
XH2_k127_8122289_7 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003896 276.0
XH2_k127_8122289_8 Oxidoreductase K00177 - 1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006605 270.0
XH2_k127_8122289_9 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000783 264.0
XH2_k127_8134651_1 - - - - 0.00000005442 63.0
XH2_k127_8172183_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1492.0
XH2_k127_8172183_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 604.0
XH2_k127_8172183_2 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 505.0
XH2_k127_8172183_3 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001393 268.0
XH2_k127_8298368_0 Belongs to the RtcB family K14415 - 6.5.1.3 1.024e-231 724.0
XH2_k127_8298368_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000002607 233.0
XH2_k127_8298368_2 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.0000000000000000000000000000000000000000000000000000000003143 205.0
XH2_k127_8298368_3 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000000000002575 179.0
XH2_k127_8298368_4 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000008954 132.0
XH2_k127_8298368_5 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000000125 130.0
XH2_k127_8298368_6 - - - - 0.00000000000000000000000051 108.0
XH2_k127_8298457_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 504.0
XH2_k127_8298457_1 Belongs to the MCM family K10726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 316.0
XH2_k127_8298457_2 metallopeptidase activity K01186 - 3.2.1.18 0.0000000004638 67.0
XH2_k127_8540377_0 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 372.0
XH2_k127_8540377_1 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000001598 177.0
XH2_k127_8540377_2 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000002855 136.0
XH2_k127_8540377_3 - - - - 0.00000000000000000002005 96.0
XH2_k127_8569186_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 528.0
XH2_k127_8569186_1 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004432 273.0
XH2_k127_8569186_2 DNA ligase D, 3-phosphoesterase domain - - - 0.0000000000000000000000000000000000003436 141.0
XH2_k127_8588224_0 methanogenesis marker protein 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 446.0
XH2_k127_8588224_1 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007429 308.0
XH2_k127_8588224_2 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000003886 203.0
XH2_k127_8588224_3 transcriptional regulators K03724 - - 0.00000000000000003361 83.0
XH2_k127_8588224_4 Belongs to the rubredoxin family - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114 - 0.00000000000000007842 80.0
XH2_k127_8622088_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007127 476.0
XH2_k127_8622088_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 386.0
XH2_k127_8622088_2 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000497 243.0
XH2_k127_8622088_3 protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000000000000000000003484 228.0
XH2_k127_8622088_4 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.000000000000000000000000000000000000000000000000000000001225 209.0
XH2_k127_8622088_5 Protein of unknown function (DUF2769) - - - 0.000000000000000000000000000000000000003251 149.0
XH2_k127_8622088_6 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000006419 74.0
XH2_k127_877239_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 7.04e-265 825.0
XH2_k127_877239_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 514.0
XH2_k127_877239_2 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006285 352.0
XH2_k127_877239_3 PFAM RDD domain containing protein - - - 0.000000000000000000000000000000000000000000007284 167.0
XH2_k127_8879920_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 5.683e-241 750.0
XH2_k127_8879920_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 548.0
XH2_k127_8879920_2 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 524.0
XH2_k127_8879920_3 coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001993 257.0
XH2_k127_8879920_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000004642 220.0
XH2_k127_8879920_5 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.0000000000000000005432 90.0
XH2_k127_8900003_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000006055 225.0
XH2_k127_8900003_1 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000000000000861 184.0
XH2_k127_8900003_2 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000000001141 132.0
XH2_k127_8900003_3 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000000000000403 112.0
XH2_k127_8900003_4 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000000009335 91.0
XH2_k127_8900003_5 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.00000001023 56.0
XH2_k127_8904452_0 ATP- binding - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000001376 100.0
XH2_k127_891233_0 PFAM major facilitator superfamily MFS_1 K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 386.0
XH2_k127_891233_1 CorA-like Mg2+ transporter protein K03284 GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006875 316.0
XH2_k127_891233_2 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000001455 220.0
XH2_k127_891233_3 methyltransferase small K07579 - - 0.00000000000000000000001408 101.0
XH2_k127_8953001_0 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001838 278.0
XH2_k127_8953001_1 - - - - 0.000000000000000000000000000005083 122.0
XH2_k127_8965589_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 467.0
XH2_k127_8965589_1 - - - - 0.00000000008684 67.0
XH2_k127_9105053_0 COG1668 ABC-type Na efflux pump, permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 579.0
XH2_k127_9105053_1 PFAM ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 380.0
XH2_k127_9105053_2 ABC-2 family transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008017 377.0
XH2_k127_9105053_3 - - - - 0.0000000000000000000000000000000003545 134.0
XH2_k127_9136193_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0 1028.0
XH2_k127_9136193_1 phosphohydrolase (DHH superfamily) K07097 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 356.0
XH2_k127_9136193_2 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005017 327.0
XH2_k127_9136193_3 COG0590 Cytosine adenosine deaminases K01485 - 3.5.4.1 0.000000000000000000000000000000000000000000000000000000000000000000004302 237.0
XH2_k127_9136193_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000004331 237.0
XH2_k127_9136193_5 HEAT repeats - - - 0.0000000000000000000000000000000000001112 151.0
XH2_k127_9199572_0 Belongs to the TCP-1 chaperonin family K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 349.0
XH2_k127_9199572_1 DEAD DEAH box helicase K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 314.0
XH2_k127_9199572_2 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000003117 101.0
XH2_k127_9199572_3 - - - - 0.0000001014 55.0
XH2_k127_9320792_0 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006424 263.0
XH2_k127_9320792_1 Ion channel K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002921 267.0
XH2_k127_9320792_2 COG1202 Superfamily II helicase, archaea-specific - - - 0.000000000000000000000000000000000000000000000000000000000008918 210.0
XH2_k127_9320792_3 PFAM phospholipase D Transphosphatidylase K06131 - - 0.0000000000000000000000000000000002291 138.0
XH2_k127_9320792_4 - - - - 0.00000000007836 68.0
XH2_k127_9320792_5 Voltage gated chloride channel - - - 0.000005895 55.0
XH2_k127_9426880_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005644 392.0
XH2_k127_9426880_1 PFAM peptidase U32 K08303 - - 0.00000000001309 66.0
XH2_k127_9428079_0 Belongs to the TPP enzyme family K00158 - 1.2.3.3 8.32e-252 793.0
XH2_k127_9428079_1 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000003491 217.0
XH2_k127_9428079_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000002346 211.0
XH2_k127_9428079_3 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000000000003423 174.0
XH2_k127_9428079_4 NAD(P)H-dependent FMN reductase - - - 0.0000682 47.0
XH2_k127_9437527_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 4.913e-194 608.0
XH2_k127_9437527_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 601.0
XH2_k127_9437527_2 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004789 563.0
XH2_k127_9437527_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 486.0
XH2_k127_9437527_4 Dihydrouridine synthase (Dus) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 439.0
XH2_k127_9437527_5 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 385.0
XH2_k127_9437527_6 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 361.0
XH2_k127_9437527_7 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.00000000000000000000000000000000000000000000000000000000009909 205.0
XH2_k127_9437527_8 - - - - 0.00000000000000000000000000000000006335 134.0
XH2_k127_9437527_9 - - - - 0.0000000000000005378 79.0
XH2_k127_9479433_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1512.0
XH2_k127_9479433_1 PFAM Aldehyde dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 555.0
XH2_k127_9479433_2 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005468 302.0
XH2_k127_9479433_3 PFAM PRC-barrel domain - - - 0.00000000000000000381 84.0
XH2_k127_9489587_0 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 437.0
XH2_k127_9489587_1 PFAM glutamate synthase alpha subunit domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006404 340.0
XH2_k127_9489587_2 Belongs to the glutamate synthase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 280.0
XH2_k127_9489587_3 PFAM PKD domain containing protein - - - 0.0000000000004451 78.0
XH2_k127_9502840_0 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.00000000000000000000000000000000000000000000000000000000000000000001994 237.0
XH2_k127_9502840_1 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000001056 201.0
XH2_k127_9502840_2 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000007366 150.0
XH2_k127_9502840_3 PFAM Radical SAM domain protein - - - 0.000000000000000000000000002506 112.0
XH2_k127_9502840_4 - - - - 0.000000000008799 69.0
XH2_k127_9521284_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1055.0
XH2_k127_9521284_1 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 542.0
XH2_k127_9521284_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000000002606 185.0
XH2_k127_9521284_3 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.00000000000000000000000001731 111.0
XH2_k127_9577533_0 Uncharacterized membrane protein (DUF2298) - - - 5.68e-199 637.0
XH2_k127_9577533_1 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003096 284.0
XH2_k127_9577533_2 MarC family integral membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008061 262.0
XH2_k127_9577533_3 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000004591 228.0
XH2_k127_9577533_4 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000000006733 199.0
XH2_k127_9577533_5 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.00000000000000000000000000000000002887 134.0
XH2_k127_9577533_6 Binds to the 23S rRNA K02896 - - 0.000000000000000000000000000007774 119.0
XH2_k127_9577533_7 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000004629 49.0
XH2_k127_96035_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.0 1013.0
XH2_k127_96035_1 TIGRFAM lysine 2,3-aminomutase YodO family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 476.0
XH2_k127_96035_2 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000001122 179.0
XH2_k127_9619312_0 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000001647 179.0
XH2_k127_9619312_1 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000003572 130.0
XH2_k127_9619312_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000006325 96.0
XH2_k127_9619312_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.00000000000000001715 83.0
XH2_k127_9621890_0 ABC 3 transport family K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 404.0
XH2_k127_9621890_1 AAA domain, putative AbiEii toxin, Type IV TA system K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000003004 233.0
XH2_k127_9621890_2 NADPH-dependent FMN reductase - - - 0.0002881 46.0
XH2_k127_9660550_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 5.953e-315 971.0
XH2_k127_9660550_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000086 385.0
XH2_k127_9660550_2 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000004815 201.0
XH2_k127_9660550_3 ThiS family K03636 - - 0.0000000000000000000000000000000000000089 146.0
XH2_k127_9660550_4 Protein of unknown function (DUF4013) - - - 0.00000000000000000008035 95.0
XH2_k127_9687604_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 578.0
XH2_k127_9687604_1 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002908 516.0
XH2_k127_9687604_2 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 444.0
XH2_k127_9687604_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001043 281.0
XH2_k127_9687604_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000003945 247.0
XH2_k127_9687604_5 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000000000000000000000000000000737 202.0
XH2_k127_9687604_6 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000001501 190.0
XH2_k127_9687604_7 - - - - 0.0000000000001161 76.0
XH2_k127_9687604_8 - K06193 - - 0.00000001579 65.0
XH2_k127_9691542_0 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits K14572 - - 0.00000000109 72.0
XH2_k127_9691542_1 Nitric oxide reductase activation protein - - - 0.0001841 53.0
XH2_k127_9705067_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 1.218e-211 662.0
XH2_k127_9705067_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 555.0
XH2_k127_9705067_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009305 293.0
XH2_k127_9705067_3 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004295 280.0
XH2_k127_9712461_0 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 518.0
XH2_k127_9712461_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000001191 264.0
XH2_k127_9712461_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000008506 200.0
XH2_k127_9731950_0 Heat shock 70 kDa protein K04043 - - 3.771e-301 929.0
XH2_k127_9731950_1 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007066 536.0
XH2_k127_9731950_2 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009229 533.0
XH2_k127_9731950_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000000528 197.0
XH2_k127_9736962_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 4.47e-267 835.0
XH2_k127_9736962_1 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 582.0
XH2_k127_9736962_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 527.0
XH2_k127_9736962_3 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001118 265.0
XH2_k127_9736962_4 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000003799 234.0
XH2_k127_9736962_5 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.000000000000000000000000000000000000000000000000001557 186.0
XH2_k127_9736962_6 Family of unknown function (DUF5350) - - - 0.000000000000000000000002148 106.0
XH2_k127_9955162_0 Ferrous iron transport B domain protein K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003816 579.0
XH2_k127_9955162_1 FeoA K03709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000784 403.0
XH2_k127_9969772_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 1.039e-212 672.0
XH2_k127_9969772_1 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000068 585.0
XH2_k127_9969772_2 PFAM AMMECR1 domain protein K09141 - - 0.0000000000000000000000000000000000000003262 150.0
XH2_k127_9977239_0 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 450.0
XH2_k127_9977239_1 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 370.0
XH2_k127_9977239_2 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 366.0
XH2_k127_9977239_3 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008338 273.0