DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
0.0
2704.0
SRR34280936_k127_136705_10
COG0553 Superfamily II DNA RNA helicases, SNF2 family
-
-
-
0.0
1995.0
SRR34280936_k127_136705_100
Sugar (and other) transporter
-
-
-
1.553e-259
810.0
SRR34280936_k127_136705_101
belongs to the aldehyde dehydrogenase family
K00130,K00151
-
1.2.1.60,1.2.1.8
9.806e-259
807.0
SRR34280936_k127_136705_102
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
2.934e-254
787.0
SRR34280936_k127_136705_103
Belongs to the isocitrate and isopropylmalate dehydrogenases family
K00031
-
1.1.1.42
1.208e-253
784.0
SRR34280936_k127_136705_104
fumarate reductase
-
-
-
4.977e-251
782.0
SRR34280936_k127_136705_105
receptor
-
-
-
5.422e-251
793.0
SRR34280936_k127_136705_106
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K00282
-
1.4.4.2
5.691e-251
779.0
SRR34280936_k127_136705_107
Von Willebrand factor A
K09989
-
-
7.846e-251
776.0
SRR34280936_k127_136705_108
Chain-length determining protein
-
-
-
3.896e-249
777.0
SRR34280936_k127_136705_109
Glycosyl hydrolase family 20, catalytic domain
K12373
-
3.2.1.52
1.147e-246
783.0
SRR34280936_k127_136705_11
RNase_H superfamily
-
-
-
0.0
1855.0
SRR34280936_k127_136705_110
DEAD DEAH box helicase
K11927
-
3.6.4.13
1.349e-246
769.0
SRR34280936_k127_136705_111
Belongs to the aspartokinase family
K00928
-
2.7.2.4
9.638e-246
762.0
SRR34280936_k127_136705_112
COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
-
-
-
1.053e-244
764.0
SRR34280936_k127_136705_113
COG2925 Exonuclease I
K01141
-
3.1.11.1
4.233e-243
756.0
SRR34280936_k127_136705_114
Belongs to the TPP enzyme family
K01652
-
2.2.1.6
1.199e-241
758.0
SRR34280936_k127_136705_115
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
1.11e-240
748.0
SRR34280936_k127_136705_116
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K02472
-
1.1.1.336
6.995e-235
731.0
SRR34280936_k127_136705_12
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0
1772.0
SRR34280936_k127_136705_120
Patatin-like phospholipase
-
-
-
1.229e-234
728.0
SRR34280936_k127_136705_121
Transfers the fatty acyl group on membrane lipoproteins
K03820
-
-
1.902e-234
735.0
SRR34280936_k127_136705_122
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
3.227e-234
729.0
SRR34280936_k127_136705_123
Conjugal transfer protein
K12060
-
-
3.216e-233
727.0
SRR34280936_k127_136705_124
methyl-accepting chemotaxis protein
K03406
-
-
1.479e-232
727.0
SRR34280936_k127_136705_125
Belongs to the MurCDEF family
K01924
-
6.3.2.8
1.058e-231
729.0
SRR34280936_k127_136705_126
acyl-CoA dehydrogenase
-
-
-
1.247e-230
717.0
SRR34280936_k127_136705_127
Protein of unknown function (DUF1343)
-
-
-
2.7e-230
717.0
SRR34280936_k127_136705_128
Amidohydrolase family
-
-
-
3.315e-230
746.0
SRR34280936_k127_136705_129
Protein of unknown function DUF262
-
-
-
2.895e-229
723.0
SRR34280936_k127_136705_13
TrwC protein
-
-
-
0.0
1764.0
SRR34280936_k127_136705_130
Belongs to the CarA family
K01956
-
6.3.5.5
1.949e-228
712.0
SRR34280936_k127_136705_131
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
K00800
-
2.5.1.19
3.439e-228
715.0
SRR34280936_k127_136705_132
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
K01929
-
6.3.2.10
1.228e-227
713.0
SRR34280936_k127_136705_133
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
6.144e-226
707.0
SRR34280936_k127_136705_134
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
8.683e-222
690.0
SRR34280936_k127_136705_135
Belongs to the 'phage' integrase family
-
-
-
6.084e-221
693.0
SRR34280936_k127_136705_136
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
8.602e-221
694.0
SRR34280936_k127_136705_137
ATPase related to the helicase subunit of the Holliday junction resolvase
K07478
-
-
1.263e-220
691.0
SRR34280936_k127_136705_138
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
5.855e-220
688.0
SRR34280936_k127_136705_139
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
4.625e-219
689.0
SRR34280936_k127_136705_14
Topoisomerase DNA binding C4 zinc finger
K03658
-
3.6.4.12
0.0
1750.0
SRR34280936_k127_136705_140
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K03684
-
3.1.13.5
5.543e-219
685.0
SRR34280936_k127_136705_141
Barrel-sandwich domain of CusB or HlyD membrane-fusion
-
-
-
6.575e-218
681.0
SRR34280936_k127_136705_142
Phosphohydrolase-associated domain
K01129
-
3.1.5.1
1.611e-217
682.0
SRR34280936_k127_136705_143
peptidylprolyl isomerase
K03771
-
5.2.1.8
8.709e-217
681.0
SRR34280936_k127_136705_144
zinc-finger binding domain of transposase IS66
-
-
-
2.863e-216
683.0
SRR34280936_k127_136705_145
Belongs to the peptidase M24B family
K01271
-
3.4.13.9
4.118e-216
676.0
SRR34280936_k127_136705_146
COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
K01295
-
3.4.17.11
1.011e-215
676.0
SRR34280936_k127_136705_147
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)
K01484
-
3.5.3.23
3.695e-214
671.0
SRR34280936_k127_136705_148
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K03553
-
-
1.878e-213
665.0
SRR34280936_k127_136705_149
dGTPase family. Type 2 subfamily
K01129
-
3.1.5.1
6.821e-213
665.0
SRR34280936_k127_136705_15
COG1002 Type II restriction enzyme, methylase subunits
-
-
-
0.0
1703.0
SRR34280936_k127_136705_150
Conjugal transfer protein
K12060
-
-
6.77e-212
662.0
SRR34280936_k127_136705_151
Phosphoribosylformylglycinamidine cyclo-ligase
K01933
-
6.3.3.1
1.452e-211
661.0
SRR34280936_k127_136705_152
Responsible for synthesis of pseudouridine from uracil
K06179
-
5.4.99.24
2.505e-211
663.0
SRR34280936_k127_136705_153
PFAM Acyl-CoA dehydrogenase, type 2, C-terminal domain
K16047
-
1.14.14.12
2.569e-211
665.0
SRR34280936_k127_136705_154
ATPase of the PP-loop superfamily implicated in cell cycle control
-
-
-
3.124e-211
663.0
SRR34280936_k127_136705_155
protein involved in virulence
-
-
-
1.246e-210
662.0
SRR34280936_k127_136705_156
AMP-dependent synthetase
-
-
-
8.981e-210
666.0
SRR34280936_k127_136705_157
Protein of unknown function (DUF1254)
-
-
-
1.362e-209
667.0
SRR34280936_k127_136705_158
Major Facilitator Superfamily
-
-
-
9.27e-209
657.0
SRR34280936_k127_136705_159
Aldehyde dehydrogenase family
K00141,K21802
-
1.2.1.28,1.2.1.67
1.64e-208
657.0
SRR34280936_k127_136705_16
COG1629 Outer membrane receptor proteins, mostly Fe transport
-
-
-
0.0
1691.0
SRR34280936_k127_136705_160
Belongs to the SEDS family
K03588
-
-
1.949e-208
654.0
SRR34280936_k127_136705_161
Amidohydrolase family
-
-
-
1.372e-207
665.0
SRR34280936_k127_136705_162
Glycosyl transferase
-
-
-
2.511e-207
649.0
SRR34280936_k127_136705_163
4-oxalomesaconate hydratase
K10220
-
4.2.1.83
4.694e-207
647.0
SRR34280936_k127_136705_164
Belongs to the amidase family
K01426
-
3.5.1.4
5.618e-207
655.0
SRR34280936_k127_136705_165
Belongs to the Orn Lys Arg decarboxylase class-II family
Involved in the biosynthesis of porphyrin-containing compound
-
-
-
1.657e-205
645.0
SRR34280936_k127_136705_17
TraG-like protein, N-terminal region
K12056
-
-
0.0
1684.0
SRR34280936_k127_136705_170
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
K00558
-
2.1.1.37
5.334e-205
643.0
SRR34280936_k127_136705_171
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
1.409e-203
641.0
SRR34280936_k127_136705_172
Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds
K01666
-
4.1.3.39
4.66e-202
632.0
SRR34280936_k127_136705_173
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
4.726e-202
636.0
SRR34280936_k127_136705_174
Protein of unknown function (DUF2493)
-
-
-
2.548e-201
627.0
SRR34280936_k127_136705_175
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
1.07e-200
634.0
SRR34280936_k127_136705_176
PTS system, glucose subfamily, IIA
K11189
-
-
1.245e-200
653.0
SRR34280936_k127_136705_177
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
1.543e-200
633.0
SRR34280936_k127_136705_178
Aldehyde dehydrogenase family
K00128
-
1.2.1.3
5.333e-199
632.0
SRR34280936_k127_136705_179
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K02346
-
2.7.7.7
4.75e-198
621.0
SRR34280936_k127_136705_18
COG3451 Type IV secretory pathway, VirB4 components
K12063
-
-
0.0
1683.0
SRR34280936_k127_136705_180
Protein of unknown function (DUF2493)
-
-
-
1.782e-197
617.0
SRR34280936_k127_136705_181
Antirestriction protein
-
-
-
3.278e-197
622.0
SRR34280936_k127_136705_182
Transmembrane exosortase (Exosortase_EpsH)
-
-
-
5.423e-197
628.0
SRR34280936_k127_136705_183
Belongs to the 'phage' integrase family
-
-
-
1.604e-196
625.0
SRR34280936_k127_136705_184
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0
1371.0
SRR34280936_k127_136705_300
COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force
K15987
-
3.6.1.1
0.0
1250.0
SRR34280936_k127_136705_350
COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.0
1150.0
SRR34280936_k127_136705_410
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K01638
-
2.3.3.9
0.0
1031.0
SRR34280936_k127_136705_550
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
protein involved in exopolysaccharide biosynthesis
K16554
-
-
1.815e-317
987.0
SRR34280936_k127_136705_630
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
K05788
-
-
0.00000000000000000000000000000000000000000008332
160.0
SRR34280936_k127_136705_634
Aromatic-ring-opening dioxygenase LigAB, LigA subunit
-
-
-
0.0000000000000000000000000000000000000000001154
162.0
SRR34280936_k127_136705_635
-
-
-
-
0.0000000000000000000000000000000000000000008407
160.0
SRR34280936_k127_136705_638
LysR family transcriptional regulator
-
-
-
0.000000000000000000000000000000000000000004693
167.0
SRR34280936_k127_136705_639
-
-
-
-
0.00000000000000000000000000000000000000001056
169.0
SRR34280936_k127_136705_64
fumarate reductase
K05898
-
1.3.99.4
2.739e-314
968.0
SRR34280936_k127_136705_640
Transcriptional regulator
-
-
-
0.00000000000000000000000000000000000000001184
163.0
SRR34280936_k127_136705_641
50S ribosomal protein L31
K02909
-
-
0.00000000000000000000000000000000000000002931
152.0
SRR34280936_k127_136705_642
type I restriction modification DNA specificity domain
-
-
-
0.00000000000000000000000000000000000000004425
161.0
SRR34280936_k127_136705_643
PIN domain
-
-
-
0.00000000000000000000000000000000000000005864
154.0
SRR34280936_k127_136705_645
-
-
-
-
0.0000000000000000000000000000000000000001762
151.0
SRR34280936_k127_136705_646
DsrE/DsrF-like family
K06039
-
-
0.0000000000000000000000000000000000000006263
154.0
SRR34280936_k127_136705_647
-
-
-
-
0.000000000000000000000000000000000000002176
148.0
SRR34280936_k127_136705_648
Uncharacterized protein conserved in bacteria (DUF2188)
-
-
-
0.000000000000000000000000000000000000002639
146.0
SRR34280936_k127_136705_649
Membrane-bound lysozyme-inhibitor of c-type lysozyme
-
-
-
0.000000000000000000000000000000000000007324
148.0
SRR34280936_k127_136705_65
Glycine dehydrogenase (aminomethyl-transferring)
K00283
-
1.4.4.2
5.902e-313
961.0
SRR34280936_k127_136705_650
-
-
-
-
0.00000000000000000000000000000000000001009
166.0
SRR34280936_k127_136705_651
Protein of unknown function (DUF2849)
-
-
-
0.00000000000000000000000000000000000001051
148.0
SRR34280936_k127_136705_652
Protein of unknown function (DUF2384)
-
-
-
0.00000000000000000000000000000000000002007
151.0
SRR34280936_k127_136705_653
-
-
-
-
0.00000000000000000000000000000000000003707
145.0
SRR34280936_k127_136705_654
helix_turn_helix multiple antibiotic resistance protein
-
-
-
0.00000000000000000000000000000000000004932
150.0
SRR34280936_k127_136705_655
-
-
-
-
0.00000000000000000000000000000000000006687
147.0
SRR34280936_k127_136705_656
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.0000000000000000000000000000000000001568
143.0
SRR34280936_k127_136705_657
Nuclear transport factor 2 (NTF2) domain
K01822
-
5.3.3.1
0.0000000000000000000000000000000000002847
145.0
SRR34280936_k127_136705_658
acyl carrier protein
-
-
-
0.0000000000000000000000000000000000003436
141.0
SRR34280936_k127_136705_66
of ABC transporters with duplicated ATPase
K15738
-
-
3.961e-310
974.0
SRR34280936_k127_136705_660
-
-
-
-
0.0000000000000000000000000000000000007143
146.0
SRR34280936_k127_136705_661
PilZ domain
-
-
-
0.000000000000000000000000000000000001191
142.0
SRR34280936_k127_136705_662
SnoaL-like domain
-
-
-
0.000000000000000000000000000000000004152
145.0
SRR34280936_k127_136705_663
-
-
-
-
0.00000000000000000000000000000000008363
136.0
SRR34280936_k127_136705_664
-
-
-
-
0.00000000000000000000000000000000008402
143.0
SRR34280936_k127_136705_665
Glycine zipper 2TM domain
-
-
-
0.0000000000000000000000000000000001263
143.0
SRR34280936_k127_136705_666
protein conserved in bacteria
-
-
-
0.0000000000000000000000000000000003305
139.0
SRR34280936_k127_136705_667
-
-
-
-
0.000000000000000000000000000000000704
132.0
SRR34280936_k127_136705_668
Conjugal transfer protein TraD
-
-
-
0.000000000000000000000000000000001324
134.0
SRR34280936_k127_136705_669
Protein of unknown function (DUF3703)
-
-
-
0.000000000000000000000000000000001437
132.0
SRR34280936_k127_136705_67
Conjugative relaxosome accessory transposon protein
K12072
-
-
1.203e-309
950.0
SRR34280936_k127_136705_670
PilZ domain
-
-
-
0.000000000000000000000000000000002563
136.0
SRR34280936_k127_136705_671
Protein of unknown function (DUF3617)
-
-
-
0.000000000000000000000000000000003639
136.0
SRR34280936_k127_136705_672
PIN domain
-
-
-
0.000000000000000000000000000000006358
131.0
SRR34280936_k127_136705_673
TIGRFAM conserved repeat domain
-
-
-
0.0000000000000000000000000000000191
135.0
SRR34280936_k127_136705_674
-
-
-
-
0.000000000000000000000000000001047
124.0
SRR34280936_k127_136705_675
-
-
-
-
0.000000000000000000000000000001557
124.0
SRR34280936_k127_136705_677
membrane
-
-
-
0.00000000000000000000000000002965
119.0
SRR34280936_k127_136705_679
Prophage CP4-57 regulatory protein (AlpA)
K07733
-
-
0.0000000000000000000000000001096
117.0
SRR34280936_k127_136705_68
COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
-
-
-
1.612e-307
955.0
SRR34280936_k127_136705_680
TIGRFAM DNA binding domain
-
-
-
0.0000000000000000000000000001181
117.0
SRR34280936_k127_136705_681
-
-
-
-
0.0000000000000000000000000002046
118.0
SRR34280936_k127_136705_682
-
-
-
-
0.0000000000000000000000000002409
120.0
SRR34280936_k127_136705_683
-
-
-
-
0.0000000000000000000000000003501
126.0
SRR34280936_k127_136705_684
-
-
-
-
0.0000000000000000000000000009241
128.0
SRR34280936_k127_136705_685
-
K12064
-
-
0.000000000000000000000000001301
121.0
SRR34280936_k127_136705_686
Protein of unknown function (DUF465)
-
-
-
0.00000000000000000000000000308
116.0
SRR34280936_k127_136705_687
PspC domain
-
-
-
0.00000000000000000000000002937
111.0
SRR34280936_k127_136705_688
Prophage CP4-57 regulatory protein (AlpA)
K07733
-
-
0.00000000000000000000000004275
110.0
SRR34280936_k127_136705_689
Bacteriophage Mu Gam like protein
-
-
-
0.00000000000000000000000008983
113.0
SRR34280936_k127_136705_69
Copper amine oxidase, N3 domain
K00276
-
1.4.3.21
6.204e-305
951.0
SRR34280936_k127_136705_690
Prophage CP4-57 regulatory protein (AlpA)
K07733
-
-
0.0000000000000000000000001664
107.0
SRR34280936_k127_136705_691
-
-
-
-
0.0000000000000000000000002958
108.0
SRR34280936_k127_136705_692
Conjugal transfer protein TraD
-
-
-
0.0000000000000000000000003117
109.0
SRR34280936_k127_136705_693
Bifunctional sulfur carrier protein thiazole synthase
K03154
-
-
0.000000000000000000000000473
105.0
SRR34280936_k127_136705_694
-
-
-
-
0.0000000000000000000000005489
105.0
SRR34280936_k127_136705_695
-
-
-
-
0.0000000000000000000000005871
106.0
SRR34280936_k127_136705_696
Helix-turn-helix XRE-family like proteins
-
-
-
0.000000000000000000000001224
107.0
SRR34280936_k127_136705_697
-
-
-
-
0.00000000000000000000000145
105.0
SRR34280936_k127_136705_698
EF-hand, calcium binding motif
-
-
-
0.000000000000000000000001537
111.0
SRR34280936_k127_136705_699
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
K03073
-
-
0.000000000000000000000002182
105.0
SRR34280936_k127_136705_7
Domain of unknown function (DUF3883)
-
-
-
0.0
2128.0
SRR34280936_k127_136705_70
receptor
K02014
-
-
3.315e-296
928.0
SRR34280936_k127_136705_700
-
-
-
-
0.000000000000000000000003066
102.0
SRR34280936_k127_136705_701
-
-
-
-
0.000000000000000000000008222
102.0
SRR34280936_k127_136705_702
cellulase activity
-
-
-
0.00000000000000000000001294
119.0
SRR34280936_k127_136705_703
methyltransferase
-
-
-
0.00000000000000000000002589
111.0
SRR34280936_k127_136705_704
-
-
-
-
0.00000000000000000000005722
106.0
SRR34280936_k127_136705_705
PspC domain protein
-
-
-
0.00000000000000000000006441
101.0
SRR34280936_k127_136705_707
-
-
-
-
0.0000000000000000000008341
105.0
SRR34280936_k127_136705_708
SnoaL-like domain
-
-
-
0.000000000000000000001907
100.0
SRR34280936_k127_136705_71
COG1629 Outer membrane receptor proteins, mostly Fe transport
K02014
-
-
1.991e-295
921.0
SRR34280936_k127_136705_711
-
-
-
-
0.00000000000000000001912
93.0
SRR34280936_k127_136705_712
protein, possibly involved in utilization of glycolate and propanediol
-
-
-
0.00000000000000000002862
97.0
SRR34280936_k127_136705_714
-
-
-
-
0.00000000000000000006842
98.0
SRR34280936_k127_136705_716
-
-
-
-
0.0000000000000000001248
96.0
SRR34280936_k127_136705_718
-
-
-
-
0.000000000000000001892
85.0
SRR34280936_k127_136705_72
2-nitropropane dioxygenase
-
-
-
8.928e-295
908.0
SRR34280936_k127_136705_720
ATPase family associated with various cellular activities (AAA)
-
-
-
0.00000000000000001547
87.0
SRR34280936_k127_136705_721
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K09862
-
-
0.000000000000000034
82.0
SRR34280936_k127_136705_725
-
-
-
-
0.000000000000000832
80.0
SRR34280936_k127_136705_726
-
-
-
-
0.000000000000001269
82.0
SRR34280936_k127_136705_727
Bacteriophage HK97-gp10, putative tail-component
-
-
-
0.000000000000002252
83.0
SRR34280936_k127_136705_73
Cell division protein FtsI penicillin-binding protein
K03587
-
3.4.16.4
3.587e-291
901.0
SRR34280936_k127_136705_730
nuclease
-
-
-
0.000000000000007313
82.0
SRR34280936_k127_136705_731
GtrA-like protein
-
-
-
0.000000000000009196
79.0
SRR34280936_k127_136705_732
-
-
-
-
0.00000000000001733
78.0
SRR34280936_k127_136705_733
HNH nucleases
K07451
-
-
0.00000000000002195
77.0
SRR34280936_k127_136705_734
Cupin
-
-
-
0.0000000000000283
82.0
SRR34280936_k127_136705_735
Type-F conjugative transfer system protein (TrbI_Ftype)
COG1961 Site-specific recombinases, DNA invertase Pin homologs
-
-
-
0.00000000001472
70.0
SRR34280936_k127_136705_744
Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT
-
-
-
0.00000000002909
74.0
SRR34280936_k127_136705_745
-
-
-
-
0.0000000002246
68.0
SRR34280936_k127_136705_746
tape measure protein
-
-
-
0.0000000005113
73.0
SRR34280936_k127_136705_747
Transcriptional regulator
K07733
-
-
0.0000000006684
64.0
SRR34280936_k127_136705_75
peptidase S10 serine carboxypeptidase
-
-
-
1.647e-290
897.0
SRR34280936_k127_136705_750
-
-
-
-
0.000000001596
60.0
SRR34280936_k127_136705_755
Helix-turn-helix domain
-
-
-
0.000000008232
58.0
SRR34280936_k127_136705_756
-
-
-
-
0.00000001007
62.0
SRR34280936_k127_136705_757
Resolvase
-
-
-
0.00000001786
66.0
SRR34280936_k127_136705_758
-
-
-
-
0.00000002945
57.0
SRR34280936_k127_136705_759
-
-
-
-
0.00000005122
56.0
SRR34280936_k127_136705_76
COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
K00666
-
-
8.221e-284
878.0
SRR34280936_k127_136705_762
AraC-like ligand binding domain
-
-
-
0.0000003169
59.0
SRR34280936_k127_136705_765
translation initiation factor activity
K00759,K20541
-
2.4.2.7
0.0000005966
59.0
SRR34280936_k127_136705_768
Staphylococcal nuclease homologue
-
-
-
0.000001989
54.0
SRR34280936_k127_136705_769
Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K03177
-
5.4.99.25
0.000006057
49.0
SRR34280936_k127_136705_77
Periplasmic component of the Tol biopolymer transport system
-
-
-
1.344e-282
900.0
SRR34280936_k127_136705_771
endoribonuclease L-PSP
-
-
-
0.00001972
57.0
SRR34280936_k127_136705_779
sequence-specific DNA binding
-
-
-
0.0005955
49.0
SRR34280936_k127_136705_78
An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
K01961
-
6.3.4.14,6.4.1.2
8.11e-281
866.0
SRR34280936_k127_136705_79
Type I restriction-modification system methyltransferase subunit
K03427
-
2.1.1.72
8.279e-281
867.0
SRR34280936_k127_136705_8
Belongs to the CarB family
K01955
-
6.3.5.5
0.0
2028.0
SRR34280936_k127_136705_80
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072
-
-
3.996e-279
865.0
SRR34280936_k127_136705_81
Conjugative relaxosome accessory transposon protein
K12072
-
-
3.091e-278
859.0
SRR34280936_k127_136705_82
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
K03455
-
-
1.487e-277
865.0
SRR34280936_k127_136705_83
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
-
3.6.4.12
1.435e-276
869.0
SRR34280936_k127_136705_84
Peptidase, M28
-
-
-
4.045e-274
853.0
SRR34280936_k127_136705_85
Copper-binding protein
-
-
-
1.761e-272
848.0
SRR34280936_k127_136705_86
Type-1V conjugative transfer system mating pair stabilisation
K12058
-
-
3.807e-272
849.0
SRR34280936_k127_136705_87
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
K00088
-
1.1.1.205
3.401e-271
847.0
SRR34280936_k127_136705_88
AAA domain (dynein-related subfamily)
K07452
-
-
7.409e-269
857.0
SRR34280936_k127_136705_89
Glutamate synthase
K00266
-
1.4.1.13,1.4.1.14
3.571e-268
830.0
SRR34280936_k127_136705_9
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
2018.0
SRR34280936_k127_136705_90
Terminase
-
-
-
7.804e-268
835.0
SRR34280936_k127_136705_91
Bacterial conjugation TrbI-like protein
K12065
-
-
4.034e-267
827.0
SRR34280936_k127_136705_92
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate
K06447
-
1.2.1.71
3.121e-260
811.0
SRR34280936_k127_142473_0
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1578.0
SRR34280936_k127_142473_1
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K03676
-
-
0.000000000000000000000000000000000000004957
147.0
SRR34280936_k127_142473_147
Helix-turn-helix domain
-
-
-
0.000000000000000000000000000000000000979
151.0
SRR34280936_k127_142473_148
Thioredoxin-like
-
-
-
0.00000000000000000000000000000000001999
142.0
SRR34280936_k127_142473_15
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
K03455,K11747
-
-
2.516e-285
890.0
SRR34280936_k127_142473_150
-
-
-
-
0.00000000000000000000000000000000005918
146.0
SRR34280936_k127_142473_151
Winged helix DNA-binding domain
-
-
-
0.0000000000000000000000000000000001416
138.0
SRR34280936_k127_142473_152
Protein of unknown function (DUF3703)
-
-
-
0.0000000000000000000000000001536
119.0
SRR34280936_k127_142473_153
-
-
-
-
0.00000000000000000000001143
105.0
SRR34280936_k127_142473_154
Bacterial regulatory helix-turn-helix protein, lysR family
K02019
-
-
0.0000000000000000000001508
104.0
SRR34280936_k127_142473_155
-
-
-
-
0.0000000000000000000001913
100.0
SRR34280936_k127_142473_156
-
-
-
-
0.0000000000000000000004458
105.0
SRR34280936_k127_142473_157
-
-
-
-
0.0000000000000000000007317
98.0
SRR34280936_k127_142473_16
Phosphate acyltransferases
K15781
-
2.3.1.51,3.1.3.3
1.584e-272
846.0
SRR34280936_k127_142473_163
Flp/Fap pilin component
K02651
-
-
0.00000000000004256
73.0
SRR34280936_k127_142473_167
Pilus assembly protein
K02651
-
-
0.000000006336
59.0
SRR34280936_k127_142473_168
Helix-turn-helix XRE-family like proteins
-
-
-
0.000000008568
62.0
SRR34280936_k127_142473_17
Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K00036
-
1.1.1.363,1.1.1.49
2.878e-269
833.0
SRR34280936_k127_142473_18
Protein of unknown function (DUF1298)
-
-
-
2.582e-263
820.0
SRR34280936_k127_142473_19
Domain of unknown function (DUF3336)
K07001
-
-
9.147e-253
786.0
SRR34280936_k127_142473_2
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.0
1225.0
SRR34280936_k127_142473_20
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
K01586
-
4.1.1.20
5.043e-252
783.0
SRR34280936_k127_142473_21
argininosuccinate lyase
K01755
-
4.3.2.1
1.826e-250
781.0
SRR34280936_k127_142473_22
Involved in the TonB-independent uptake of proteins
K03641
-
-
1.837e-250
780.0
SRR34280936_k127_142473_23
Alkaline phosphatase with broad substrate specificity
K01077
-
3.1.3.1
3.622e-248
777.0
SRR34280936_k127_142473_24
Aldehyde dehydrogenase family
K00128
-
1.2.1.3
9.788e-247
770.0
SRR34280936_k127_142473_25
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
1.768e-246
766.0
SRR34280936_k127_142473_26
PFAM Serine dehydratase alpha chain
K01752
-
4.3.1.17
5.649e-245
762.0
SRR34280936_k127_142473_27
Belongs to the thiolase family
K00626
-
2.3.1.9
5.528e-240
751.0
SRR34280936_k127_142473_28
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K03526
-
1.17.7.1,1.17.7.3
1.313e-238
743.0
SRR34280936_k127_142473_29
Threonine dehydratase
K01754
-
4.3.1.19
3.435e-237
737.0
SRR34280936_k127_142473_3
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0
1152.0
SRR34280936_k127_142473_30
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00526
-
1.17.4.1
1.316e-233
723.0
SRR34280936_k127_142473_31
General secretion pathway protein E
K02454
-
-
2.677e-232
730.0
SRR34280936_k127_142473_32
Belongs to the thiolase family
K00626
-
2.3.1.9
7.623e-231
718.0
SRR34280936_k127_142473_33
FAD dependent oxidoreductase
-
-
-
3.567e-230
720.0
SRR34280936_k127_142473_34
Uncharacterized ACR, YdiU/UPF0061 family
-
-
-
4.766e-230
723.0
SRR34280936_k127_142473_35
-
-
-
-
8.013e-230
726.0
SRR34280936_k127_142473_36
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily
K00121
-
1.1.1.1,1.1.1.284
1.896e-225
700.0
SRR34280936_k127_142473_37
peptidase M48, Ste24p
-
-
-
4.093e-224
704.0
SRR34280936_k127_142473_38
Dehydrogenase
K00101,K15054
-
1.1.2.3,1.1.99.31
1.242e-223
698.0
SRR34280936_k127_142473_39
acyl-CoA dehydrogenase
-
-
-
1.647e-219
687.0
SRR34280936_k127_142473_4
Belongs to the GPAT DAPAT family
K00631
-
2.3.1.15
0.0
1131.0
SRR34280936_k127_142473_40
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively
K01556
-
3.7.1.3
2.139e-217
684.0
SRR34280936_k127_142473_41
HI0933-like protein
K07007
-
-
5.988e-213
668.0
SRR34280936_k127_142473_42
Bacteriophage Mu transposase
-
-
-
8.823e-213
678.0
SRR34280936_k127_142473_43
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
K00566
-
2.8.1.13
3.377e-211
659.0
SRR34280936_k127_142473_44
tail specific protease
-
-
-
3.49e-204
643.0
SRR34280936_k127_142473_45
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
K03551
-
3.6.4.12
2.753e-201
629.0
SRR34280936_k127_142473_46
) H( ) antiporter that extrudes sodium in exchange for external protons
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K02274
-
1.9.3.1
0.0
1031.0
SRR34280936_k127_18600_150
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K02963
-
-
0.0000000000000000000000000000000000002986
141.0
SRR34280936_k127_18600_248
-
-
-
-
0.000000000000000000000000000000000001545
150.0
SRR34280936_k127_18600_249
-
-
-
-
0.000000000000000000000000000000000004313
143.0
SRR34280936_k127_18600_25
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
1.328e-292
902.0
SRR34280936_k127_18600_250
COG4381 Mu-like prophage protein gp46
-
-
-
0.000000000000000000000000000000000007069
141.0
SRR34280936_k127_18600_251
Phage derived protein Gp49-like (DUF891)
-
-
-
0.00000000000000000000000000000000001566
138.0
SRR34280936_k127_18600_252
PilZ domain
-
-
-
0.0000000000000000000000000000000004786
135.0
SRR34280936_k127_18600_253
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.000000000000000000000000000000001471
129.0
SRR34280936_k127_18600_254
Pfam Polyketide cyclase dehydrase and lipid transport
-
-
-
0.000000000000000000000000000000003338
133.0
SRR34280936_k127_18600_255
TRANSCRIPTIONal
-
-
-
0.0000000000000000000000000000000186
128.0
SRR34280936_k127_18600_256
-
-
-
-
0.00000000000000000000000000000008463
129.0
SRR34280936_k127_18600_258
Belongs to the BolA IbaG family
-
-
-
0.000000000000000000000000000001072
123.0
SRR34280936_k127_18600_259
Belongs to the bacterial ribosomal protein bS21 family
K02970
-
-
0.000000000000000000000000000004059
122.0
SRR34280936_k127_18600_26
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
1.088e-289
895.0
SRR34280936_k127_18600_260
-
-
-
-
0.00000000000000000000000000001172
128.0
SRR34280936_k127_18600_261
-
-
-
-
0.00000000000000000000000000001942
119.0
SRR34280936_k127_18600_263
-
-
-
-
0.0000000000000000000000000001601
119.0
SRR34280936_k127_18600_264
Transcriptional regulator
K07729
-
-
0.000000000000000000000000003081
114.0
SRR34280936_k127_18600_265
Phage virion morphogenesis family
-
-
-
0.00000000000000000000000001531
115.0
SRR34280936_k127_18600_267
Helix-turn-helix domain
-
-
-
0.0000000000000000000000001023
113.0
SRR34280936_k127_18600_268
PFAM YcfA-like
-
-
-
0.00000000000000000000000268
103.0
SRR34280936_k127_18600_269
-
-
-
-
0.000000000000000000000003094
108.0
SRR34280936_k127_18600_27
Belongs to the class-I aminoacyl-tRNA synthetase family
K04566
-
6.1.1.6
1.252e-285
885.0
SRR34280936_k127_18600_270
Mu-like prophage protein
-
-
-
0.00000000000000000000001101
116.0
SRR34280936_k127_18600_271
PFAM Uncharacterised protein family UPF0150
-
-
-
0.00000000000000000000002295
100.0
SRR34280936_k127_18600_273
MORN variant repeat protein
-
-
-
0.0000000000000000000001963
106.0
SRR34280936_k127_18600_274
Pfam:N_methyl_2
-
-
-
0.0000000000000000000003567
105.0
SRR34280936_k127_18600_276
DNA restriction-modification system
K19147
-
-
0.0000000000000000000006526
109.0
SRR34280936_k127_18600_279
-
-
-
-
0.00000000000006689
79.0
SRR34280936_k127_18600_28
Catalyzes the synthesis of GMP from XMP
K01951
-
6.3.5.2
4.344e-283
877.0
SRR34280936_k127_18600_281
Phage Tail Collar Domain
-
-
-
0.00000000000334
75.0
SRR34280936_k127_18600_282
Protein of unknown function (DUF1320)
-
-
-
0.0000000000104
70.0
SRR34280936_k127_18600_285
Sel1-like repeats.
K07126
-
-
0.0000008473
62.0
SRR34280936_k127_18600_286
Domain of unknown function (DUF3472)
-
-
-
0.00000179
60.0
SRR34280936_k127_18600_287
-
-
-
-
0.000009117
57.0
SRR34280936_k127_18600_288
Type IV pili methyl-accepting chemotaxis transducer N-term
Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K03177
-
5.4.99.25
0.0004631
45.0
SRR34280936_k127_18600_3
4Fe-4S dicluster domain
-
-
-
0.0
1405.0
SRR34280936_k127_18600_30
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
3.135e-276
852.0
SRR34280936_k127_18600_31
belongs to the aldehyde dehydrogenase family
-
-
-
9.615e-274
846.0
SRR34280936_k127_18600_32
COG2831 Hemolysin activation secretion protein
-
-
-
2.545e-272
851.0
SRR34280936_k127_18600_33
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
2.842e-272
843.0
SRR34280936_k127_18600_34
Belongs to the pyruvate kinase family
K00873
-
2.7.1.40
3.841e-271
839.0
SRR34280936_k127_18600_35
gamma-glutamyltranspeptidase
K00681
-
2.3.2.2,3.4.19.13
7.139e-263
822.0
SRR34280936_k127_18600_36
Belongs to the argininosuccinate synthase family. Type 1 subfamily
K01940
-
6.3.4.5
4.089e-262
808.0
SRR34280936_k127_18600_37
protein conserved in bacteria
-
-
-
3.38e-261
841.0
SRR34280936_k127_18600_38
Aminotransferase
K14261
-
-
7.141e-260
807.0
SRR34280936_k127_18600_39
Cytochrome p450
-
-
-
1.991e-259
804.0
SRR34280936_k127_18600_4
Helicase
K03722
-
3.6.4.12
0.0
1404.0
SRR34280936_k127_18600_40
Retinal pigment epithelial membrane protein
K21822
-
1.13.11.82
8.73e-258
802.0
SRR34280936_k127_18600_41
Threonine synthase
K01733
-
4.2.3.1
1.938e-256
795.0
SRR34280936_k127_18600_42
Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine
K01761
-
4.4.1.11
2.473e-255
790.0
SRR34280936_k127_18600_43
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
K06941
-
2.1.1.192
1.026e-254
788.0
SRR34280936_k127_18600_44
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
7.113e-254
785.0
SRR34280936_k127_18600_45
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
6.326e-248
773.0
SRR34280936_k127_18600_48
protein conserved in bacteria
-
-
-
2.602e-235
744.0
SRR34280936_k127_18600_49
UDP-N-acetylmuramate-alanine ligase
K01924
-
6.3.2.8
2.268e-234
731.0
SRR34280936_k127_18600_5
aminopeptidase N
K01256
-
3.4.11.2
0.0
1351.0
SRR34280936_k127_18600_50
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
1.706e-233
727.0
SRR34280936_k127_18600_51
Sodium:sulfate symporter transmembrane region
K14445
-
-
9.528e-230
722.0
SRR34280936_k127_18600_52
Domain of unknown function (DUF4153)
-
-
-
9.99e-230
743.0
SRR34280936_k127_18600_53
sorbosone
-
-
-
1.075e-229
722.0
SRR34280936_k127_18600_54
Belongs to the peptidase M17 family
K01255
-
3.4.11.1
3.087e-229
717.0
SRR34280936_k127_18600_55
Flavin-binding monooxygenase-like
-
-
-
5.006e-229
720.0
SRR34280936_k127_18600_56
AAA domain (dynein-related subfamily)
K07452
-
-
1.254e-228
718.0
SRR34280936_k127_18600_57
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K00831
-
2.6.1.52
9.179e-228
708.0
SRR34280936_k127_18600_58
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
1.898e-225
703.0
SRR34280936_k127_18600_59
membrane
-
-
-
4.899e-225
703.0
SRR34280936_k127_18600_6
protein conserved in bacteria
-
-
-
0.0
1289.0
SRR34280936_k127_18600_60
Bacterial extracellular solute-binding proteins, family 5 Middle
-
-
-
3.599e-221
697.0
SRR34280936_k127_18600_61
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K01736
-
4.2.3.5
2.175e-216
676.0
SRR34280936_k127_18600_62
COG1228 Imidazolonepropionase and related amidohydrolases
-
-
-
1.66e-215
675.0
SRR34280936_k127_18600_63
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
6.684e-212
666.0
SRR34280936_k127_18600_64
Methionine gamma-lyase
-
-
-
1.106e-210
660.0
SRR34280936_k127_18600_65
Aerobic cobaltochelatase subunit CobS
K09882
-
6.6.1.2
7.272e-209
651.0
SRR34280936_k127_18600_66
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K00053
-
1.1.1.86
2.069e-208
650.0
SRR34280936_k127_18600_67
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08289
-
2.1.2.2
1.272e-206
647.0
SRR34280936_k127_18600_68
dihydroorotase
K01465
-
3.5.2.3
1.646e-205
646.0
SRR34280936_k127_18600_69
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K03517
-
2.5.1.72
2.689e-200
625.0
SRR34280936_k127_18600_7
ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component
K02004
-
-
0.0
1255.0
SRR34280936_k127_18600_70
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
K03621
-
2.3.1.15
1.174e-195
612.0
SRR34280936_k127_18600_71
Serine aminopeptidase, S33
K06889
-
-
5.499e-195
616.0
SRR34280936_k127_18600_72
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
9.346e-243
753.0
SRR34280936_k127_501517_27
acyl-CoA dehydrogenase
K00255
-
1.3.8.8
1.072e-242
753.0
SRR34280936_k127_501517_28
component I
K01665,K03342
-
2.6.1.85,4.1.3.38
1.658e-238
751.0
SRR34280936_k127_501517_29
Amidohydrolase family
-
-
-
1.811e-231
725.0
SRR34280936_k127_501517_3
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02621
-
-
0.0
1352.0
SRR34280936_k127_501517_30
Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
K00812
-
2.6.1.1
8.822e-231
719.0
SRR34280936_k127_501517_31
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
K01679
-
4.2.1.2
9.514e-230
719.0
SRR34280936_k127_501517_32
peptidase M20
K01295
-
3.4.17.11
1.041e-218
685.0
SRR34280936_k127_501517_33
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
8.136e-218
679.0
SRR34280936_k127_501517_34
Belongs to the AlaDH PNT family
K00259
-
1.4.1.1
2.031e-214
669.0
SRR34280936_k127_501517_35
4-hydroxyphenylpyruvate dioxygenase
K00457
-
1.13.11.27
5.739e-213
667.0
SRR34280936_k127_501517_36
COG0332 3-oxoacyl- acyl-carrier-protein synthase III
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1613.0
SRR34280936_k127_614016_10
protease with the C-terminal PDZ
-
-
-
0.0
1038.0
SRR34280936_k127_614016_11
Oxidoreductase
-
-
-
1.051e-314
974.0
SRR34280936_k127_614016_12
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Produces ATP from ADP in the presence of a proton gradient across the membrane
K02113,K02114
-
-
0.00000000000000000000000000000000000894
138.0
SRR34280936_k127_649831_154
COG2801 Transposase and inactivated derivatives
-
-
-
0.00000000000000000000000000000000001428
138.0
SRR34280936_k127_649831_155
Large family of predicted nucleotide-binding domains
-
-
-
0.000000000000000000000000000000001024
134.0
SRR34280936_k127_649831_156
protein conserved in bacteria
-
-
-
0.000000000000000000000000000000002875
133.0
SRR34280936_k127_649831_158
Putative lumazine-binding
-
-
-
0.00000000000000000000000000007225
120.0
SRR34280936_k127_649831_159
Hemerythrin HHE cation binding domain
-
-
-
0.00000000000000000000000000114
119.0
SRR34280936_k127_649831_16
TonB-dependent receptor plug
K02014
-
-
0.0
1114.0
SRR34280936_k127_649831_160
Peptidase inhibitor I78 family
-
-
-
0.000000000000000000000001436
106.0
SRR34280936_k127_649831_161
Transcriptional regulator
-
-
-
0.000000000000000000000001493
104.0
SRR34280936_k127_649831_164
-
-
-
-
0.0000000000000000001198
92.0
SRR34280936_k127_649831_167
SpoVT / AbrB like domain
K07172
-
-
0.000000000000006999
78.0
SRR34280936_k127_649831_169
-
-
-
-
0.000000000001511
75.0
SRR34280936_k127_649831_17
-
-
-
-
0.0
1081.0
SRR34280936_k127_649831_170
Transposase or inactivated derivative
K07494
-
-
0.000000000003912
66.0
SRR34280936_k127_649831_173
transferase activity, transferring glycosyl groups
-
-
-
0.00006763
47.0
SRR34280936_k127_649831_18
COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
K00666
-
-
0.0
1054.0
SRR34280936_k127_649831_19
Haem-degrading
-
-
-
0.0
1050.0
SRR34280936_k127_649831_2
COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit
K01469
-
3.5.2.9
0.0
1708.0
SRR34280936_k127_649831_20
Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K01712
-
4.2.1.49
0.0
1002.0
SRR34280936_k127_649831_21
DNA helicase
K03654
-
3.6.4.12
1.317e-317
980.0
SRR34280936_k127_649831_22
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase
K06147
-
-
2.233e-312
966.0
SRR34280936_k127_649831_23
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
6.859e-311
955.0
SRR34280936_k127_649831_24
Catalyzes the oxidation of L-aspartate to iminoaspartate
K00278
-
1.4.3.16
1.012e-304
941.0
SRR34280936_k127_649831_25
Protein of unknown function (DUF1524)
-
-
-
2.471e-304
945.0
SRR34280936_k127_649831_26
Flp pilus assembly protein, ATPase CpaF
K02283
-
-
4.145e-297
917.0
SRR34280936_k127_649831_27
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K02112
-
3.6.3.14
4.902e-297
915.0
SRR34280936_k127_649831_28
Belongs to the GMC oxidoreductase family
-
-
-
1.171e-292
903.0
SRR34280936_k127_649831_29
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K01251
-
3.3.1.1
1.56e-292
900.0
SRR34280936_k127_649831_3
DNA methylase
-
-
-
0.0
1663.0
SRR34280936_k127_649831_30
DNA segregation ATPase FtsK SpoIIIE
K03466
-
-
4.04e-286
898.0
SRR34280936_k127_649831_31
Belongs to the Glu Leu Phe Val dehydrogenases family
K00261,K00262
-
1.4.1.3,1.4.1.4
2.668e-280
863.0
SRR34280936_k127_649831_32
Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations
K01241
-
3.2.2.4
2.33e-279
865.0
SRR34280936_k127_649831_33
protease with the C-terminal PDZ
-
-
-
4.791e-279
871.0
SRR34280936_k127_649831_34
peptidase U62, modulator of DNA gyrase
K03568
-
-
2.762e-275
850.0
SRR34280936_k127_649831_35
Major Facilitator Superfamily
-
-
-
2.92e-270
839.0
SRR34280936_k127_649831_36
Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K00012
-
1.1.1.22
9.391e-247
766.0
SRR34280936_k127_649831_37
Histidine
K01745
-
4.3.1.3
9.429e-247
772.0
SRR34280936_k127_649831_38
COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
K00528
-
1.18.1.2,1.19.1.1
1.137e-244
759.0
SRR34280936_k127_649831_39
COG1012 NAD-dependent aldehyde dehydrogenases
K13922,K15515
-
1.2.1.81,1.2.1.87
6.35e-243
756.0
SRR34280936_k127_649831_4
Belongs to the helicase family. UvrD subfamily
K16898
-
3.6.4.12
0.0
1449.0
SRR34280936_k127_649831_40
Arm DNA-binding domain
-
-
-
1.104e-239
746.0
SRR34280936_k127_649831_41
Acyl-CoA dehydrogenase, C-terminal domain
K00249
-
1.3.8.7
5.704e-234
727.0
SRR34280936_k127_649831_42
Cytochrome c554 and c-prime
-
-
-
1.261e-230
722.0
SRR34280936_k127_649831_43
acyl-CoA dehydrogenase
K00249
-
1.3.8.7
1.359e-230
717.0
SRR34280936_k127_649831_44
homoserine dehydrogenase
K00003
-
1.1.1.3
1.58e-229
717.0
SRR34280936_k127_649831_45
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
4.212e-229
713.0
SRR34280936_k127_649831_46
overlaps another CDS with the same product name
-
-
-
4.945e-226
706.0
SRR34280936_k127_649831_47
Toxic anion resistance
-
-
-
3.304e-223
695.0
SRR34280936_k127_649831_48
amidohydrolase
-
-
-
6.102e-221
703.0
SRR34280936_k127_649831_49
Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family
K03185
-
-
1.132e-218
683.0
SRR34280936_k127_649831_5
TonB dependent receptor
-
-
-
0.0
1386.0
SRR34280936_k127_649831_50
membrane
K12340
-
-
6.707e-215
677.0
SRR34280936_k127_649831_51
COG0733 Na -dependent transporters of the SNF family
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951,K01139
-
2.7.6.5,3.1.7.2
0.0
1248.0
SRR34280936_k127_649831_70
Belongs to the enoyl-CoA hydratase isomerase family
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
COG1629 Outer membrane receptor proteins, mostly Fe transport
K02014
-
-
0.0
1354.0
SRR34280936_k127_680595_1
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
0.0
1259.0
SRR34280936_k127_680595_10
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K01610
-
4.1.1.49
2.178e-309
954.0
SRR34280936_k127_680595_11
Major facilitator superfamily
K03446
-
-
1.53e-282
875.0
SRR34280936_k127_680595_12
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
2.207e-263
814.0
SRR34280936_k127_680595_13
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03106
-
3.6.5.4
6.443e-259
812.0
SRR34280936_k127_680595_14
membrane
-
-
-
9.882e-254
794.0
SRR34280936_k127_680595_15
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
-
-
-
4.592e-250
783.0
SRR34280936_k127_680595_16
Histidine kinase
K14980
-
2.7.13.3
2.6e-242
760.0
SRR34280936_k127_680595_17
Trypsin-like peptidase domain
-
-
-
8.081e-216
683.0
SRR34280936_k127_680595_18
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
-
-
-
0.0
1085.0
SRR34280936_k127_680595_70
-
-
-
-
0.00000000000000000000000000000002704
128.0
SRR34280936_k127_680595_71
PIN domain
K18828
-
-
0.00000000000000000000000000000005802
128.0
SRR34280936_k127_680595_72
Subtilase family
-
-
-
0.0000000000000000000000000000001984
144.0
SRR34280936_k127_680595_73
COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
K04762
-
-
0.000000000000000000000000000005115
123.0
SRR34280936_k127_680595_74
Virulence-associated protein
K18829
-
-
0.000000000000000000000000001004
115.0
SRR34280936_k127_680595_75
-
-
-
-
0.000000000000000000000000008541
113.0
SRR34280936_k127_680595_8
protein conserved in bacteria
-
-
-
0.0
1028.0
SRR34280936_k127_680595_9
peptidase S9
K01278
-
3.4.14.5
5e-324
1015.0
SRR34280936_k127_786152_0
CARDB
-
-
-
0.0
12938.0
SRR34280936_k127_786152_1
Domain of unknown function DUF11
-
-
-
0.0
2571.0
SRR34280936_k127_786152_10
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0
1542.0
SRR34280936_k127_786152_100
Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide
K01739,K10764
-
2.5.1.48
1.112e-231
721.0
SRR34280936_k127_786152_101
Transporter
-
-
-
2.018e-231
732.0
SRR34280936_k127_786152_102
Belongs to the DEAD box helicase family
-
-
-
3.413e-231
724.0
SRR34280936_k127_786152_103
Na -driven multidrug efflux pump
-
-
-
2.863e-227
712.0
SRR34280936_k127_786152_104
amidohydrolase
-
-
-
3.736e-225
703.0
SRR34280936_k127_786152_105
Major facilitator superfamily
-
-
-
4.35e-222
694.0
SRR34280936_k127_786152_106
Major facilitator superfamily
K08218
-
-
2.862e-221
693.0
SRR34280936_k127_786152_107
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
K06942
-
-
2.941e-220
687.0
SRR34280936_k127_786152_11
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1387.0
SRR34280936_k127_786152_110
FAD linked
-
-
-
5.061e-220
690.0
SRR34280936_k127_786152_111
Belongs to the N(4) N(6)-methyltransferase family
K13581
-
2.1.1.72
2.013e-218
681.0
SRR34280936_k127_786152_112
Protein tyrosine kinase
K12132
-
2.7.11.1
2.836e-218
703.0
SRR34280936_k127_786152_113
Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily
K13747
-
4.1.1.96
5.002e-218
683.0
SRR34280936_k127_786152_114
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K04042
-
2.3.1.157,2.7.7.23
1.944e-217
684.0
SRR34280936_k127_786152_115
Domain present in phytochromes and cGMP-specific phosphodiesterases.
-
-
-
3.943e-217
695.0
SRR34280936_k127_786152_116
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K00337
-
1.6.5.3
3.979e-217
676.0
SRR34280936_k127_786152_117
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00343
-
1.6.5.3
1.01e-216
684.0
SRR34280936_k127_786152_118
COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit
K00175
-
1.2.7.11,1.2.7.3
9.544e-216
673.0
SRR34280936_k127_786152_119
Peptidase, M28
-
-
-
1.006e-212
669.0
SRR34280936_k127_786152_12
Methylmalonyl-CoA mutase
K01847
-
5.4.99.2
0.0
1347.0
SRR34280936_k127_786152_120
Histidine kinase
-
-
-
2.353e-212
672.0
SRR34280936_k127_786152_121
nuclear chromosome segregation
-
-
-
4.496e-212
684.0
SRR34280936_k127_786152_122
Transmembrane secretion effector
-
-
-
6.802e-212
664.0
SRR34280936_k127_786152_123
rod shape-determining protein MreB
K03569
-
-
6.352e-211
663.0
SRR34280936_k127_786152_124
ABC-type transport system, involved in lipoprotein release, permease component
COG1680 Beta-lactamase class C and other penicillin binding proteins
-
-
-
1.356e-208
653.0
SRR34280936_k127_786152_128
synthase
K00574
-
2.1.1.79
1.847e-208
655.0
SRR34280936_k127_786152_129
Nitronate monooxygenase
-
-
-
2.878e-207
649.0
SRR34280936_k127_786152_13
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02622
-
-
0.0
1293.0
SRR34280936_k127_786152_130
Belongs to the peptidase S16 family
-
-
-
6.233e-207
683.0
SRR34280936_k127_786152_131
Tetratricopeptide repeat
-
-
-
2.315e-206
659.0
SRR34280936_k127_786152_132
Acyl-CoA dehydrogenase, N-terminal domain
-
-
-
1.091e-204
641.0
SRR34280936_k127_786152_133
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00161
-
1.2.4.1
3.843e-204
640.0
SRR34280936_k127_786152_134
Periplasmic copper-binding protein (NosD)
-
-
-
1.77e-203
644.0
SRR34280936_k127_786152_135
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.0
1275.0
SRR34280936_k127_786152_150
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
K03703
-
-
0.0
1133.0
SRR34280936_k127_786152_220
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.0
1036.0
SRR34280936_k127_786152_330
Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Toxic component of a toxin-antitoxin (TA) module. An RNase
-
-
-
0.0000000000000000000000000000000000000000000273
164.0
SRR34280936_k127_786152_399
-
-
-
-
0.000000000000000000000000000000000000000000111
162.0
SRR34280936_k127_786152_4
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0
1794.0
SRR34280936_k127_786152_40
acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
K01966
-
2.1.3.15,6.4.1.3
4.872e-318
975.0
SRR34280936_k127_786152_400
-
-
-
-
0.0000000000000000000000000000000000000000001992
162.0
SRR34280936_k127_786152_401
protein conserved in bacteria
K09984
-
-
0.0000000000000000000000000000000000000000003925
157.0
SRR34280936_k127_786152_402
Septum formation initiator
-
-
-
0.000000000000000000000000000000000000000001058
159.0
SRR34280936_k127_786152_403
-
-
-
-
0.000000000000000000000000000000000000000001268
159.0
SRR34280936_k127_786152_404
-
-
-
-
0.000000000000000000000000000000000000000001289
158.0
SRR34280936_k127_786152_405
-
-
-
-
0.000000000000000000000000000000000000000001451
159.0
SRR34280936_k127_786152_406
protein conserved in bacteria
-
-
-
0.000000000000000000000000000000000000000003695
161.0
SRR34280936_k127_786152_407
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
K03117
-
-
0.00000000000000000000000000000000000000001577
155.0
SRR34280936_k127_786152_408
-
-
-
-
0.00000000000000000000000000000000000000005605
154.0
SRR34280936_k127_786152_409
chorismate mutase
K04782
-
4.2.99.21
0.0000000000000000000000000000000000000001185
152.0
SRR34280936_k127_786152_41
acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
K01969
-
6.4.1.4
1.66e-314
968.0
SRR34280936_k127_786152_410
Preprotein translocase subunit SecG
K03075
-
-
0.0000000000000000000000000000000000000002259
154.0
SRR34280936_k127_786152_411
ETC complex I subunit
-
-
-
0.0000000000000000000000000000000000000002743
151.0
SRR34280936_k127_786152_412
chorismate mutase
K04092
-
5.4.99.5
0.0000000000000000000000000000000000000006101
155.0
SRR34280936_k127_786152_413
metallopeptidase activity
-
-
-
0.00000000000000000000000000000000000000129
176.0
SRR34280936_k127_786152_414
Pfam:DUF1049
K08992
-
-
0.00000000000000000000000000000000000002465
146.0
SRR34280936_k127_786152_415
RelE-like toxin of type II toxin-antitoxin system HigB
-
-
-
0.00000000000000000000000000000000002249
137.0
SRR34280936_k127_786152_416
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
K08311
-
-
0.00000000000000000000000000000000002447
139.0
SRR34280936_k127_786152_417
Domain of unknown function (DUF4170)
-
-
-
0.00000000000000000000000000000000002638
135.0
SRR34280936_k127_786152_418
Protein of unknown function (DUF3467)
-
-
-
0.00000000000000000000000000000000004559
136.0
SRR34280936_k127_786152_42
Belongs to the IlvD Edd family
K01687
-
4.2.1.9
1.891e-313
966.0
SRR34280936_k127_786152_420
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K02110
-
-
0.000000000000000000000000000000000125
133.0
SRR34280936_k127_786152_421
Belongs to the CinA family
K03743
-
3.5.1.42
0.0000000000000000000000000000000003906
141.0
SRR34280936_k127_786152_422
Protein of unknown function (DUF1467)
-
-
-
0.0000000000000000000000000000000008366
131.0
SRR34280936_k127_786152_423
function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
K02116
-
-
0.0000000000000000000000000000000009395
134.0
SRR34280936_k127_786152_424
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K09888
-
-
0.000000000000000000000000000000001193
134.0
SRR34280936_k127_786152_425
-
-
-
-
0.000000000000000000000000000001512
128.0
SRR34280936_k127_786152_426
Protein of unknown function (DUF559)
-
-
-
0.000000000000000000000000000006561
126.0
SRR34280936_k127_786152_427
Protein of unknown function (DUF2794)
-
-
-
0.00000000000000000000000000004807
120.0
SRR34280936_k127_786152_428
-
-
-
-
0.0000000000000000000000000001357
119.0
SRR34280936_k127_786152_429
-
-
-
-
0.0000000000000000000000000001474
116.0
SRR34280936_k127_786152_43
Transporter
-
-
-
3.588e-312
967.0
SRR34280936_k127_786152_430
Relaxase/Mobilisation nuclease domain
-
-
-
0.0000000000000000000000000001699
116.0
SRR34280936_k127_786152_431
Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K03636
-
-
0.0000000000000000000000000003636
115.0
SRR34280936_k127_786152_432
Cold shock
K03704
-
-
0.0000000000000000000000000006838
117.0
SRR34280936_k127_786152_433
Protein of unknown function (DUF2842)
-
-
-
0.0000000000000000000000000008966
114.0
SRR34280936_k127_786152_434
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.000000000000000000000000002349
113.0
SRR34280936_k127_786152_436
HNH nucleases
-
-
-
0.0000000000000000000000000944
111.0
SRR34280936_k127_786152_437
-
-
-
-
0.0000000000000000000000001322
117.0
SRR34280936_k127_786152_438
RadC-like JAB domain
-
-
-
0.0000000000000000000000001756
110.0
SRR34280936_k127_786152_439
Domain of unknown function (DUF1508)
K09946
-
-
0.0000000000000000000000002072
106.0
SRR34280936_k127_786152_44
Arginyl-tRNA synthetase
K01887
-
6.1.1.19
1.697e-311
960.0
SRR34280936_k127_786152_440
-
-
-
-
0.00000000000000000000001014
103.0
SRR34280936_k127_786152_441
Transcriptional regulator
K07729
-
-
0.00000000000000000000002266
101.0
SRR34280936_k127_786152_442
Helix-turn-helix domain
-
-
-
0.000000000000000000005131
94.0
SRR34280936_k127_786152_443
Helix-turn-helix XRE-family like proteins
K21498
-
-
0.00000000000000000001075
94.0
SRR34280936_k127_786152_444
Ribbon-helix-helix protein, copG family
-
-
-
0.00000000000000000001935
93.0
SRR34280936_k127_786152_446
Protein of unknown function (DUF1674)
-
-
-
0.0000000000000000008201
88.0
SRR34280936_k127_786152_448
endonuclease containing a URI domain
K07461
-
-
0.000000000000000002917
86.0
SRR34280936_k127_786152_45
COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
K00666,K20034
-
6.2.1.44
3.265e-311
957.0
SRR34280936_k127_786152_450
YnbE-like lipoprotein
-
-
-
0.00000000000000001105
84.0
SRR34280936_k127_786152_454
-
-
-
-
0.00000000000001229
75.0
SRR34280936_k127_786152_455
COG2801 Transposase and inactivated derivatives
-
-
-
0.0000000000001116
70.0
SRR34280936_k127_786152_456
-
-
-
-
0.0000000000004063
70.0
SRR34280936_k127_786152_457
4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process
-
-
-
0.00000000000404
71.0
SRR34280936_k127_786152_459
heat shock protein binding
-
-
-
0.0000000001741
72.0
SRR34280936_k127_786152_46
Peptidase, M28
-
-
-
7.421e-310
956.0
SRR34280936_k127_786152_462
Protein kinase domain
-
-
-
0.0000000007282
68.0
SRR34280936_k127_786152_463
-
-
-
-
0.000000002749
66.0
SRR34280936_k127_786152_466
SnoaL-like polyketide cyclase
-
-
-
0.00000007498
60.0
SRR34280936_k127_786152_469
Protein of unknown function (DUF3667)
-
-
-
0.0000006354
60.0
SRR34280936_k127_786152_47
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)
K01881
-
6.1.1.15
2.279e-307
945.0
SRR34280936_k127_786152_470
-
-
-
-
0.000001483
52.0
SRR34280936_k127_786152_471
Recombinase zinc beta ribbon domain
-
-
-
0.00000294
51.0
SRR34280936_k127_786152_472
-
-
-
-
0.00002373
52.0
SRR34280936_k127_786152_474
-
-
-
-
0.0001091
49.0
SRR34280936_k127_786152_475
COG1226 Kef-type K transport systems
K10716
-
-
0.0001291
46.0
SRR34280936_k127_786152_476
-
-
-
-
0.0001616
46.0
SRR34280936_k127_786152_478
Aminoglycoside phosphotransferase
-
-
-
0.0004857
43.0
SRR34280936_k127_786152_48
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K03572
-
-
4.956e-306
946.0
SRR34280936_k127_786152_49
Alkaline phosphatase
K01113
-
3.1.3.1
9.397e-303
933.0
SRR34280936_k127_786152_5
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K15726
-
-
0.0
1736.0
SRR34280936_k127_786152_50
Major Facilitator
-
-
-
5.324e-290
897.0
SRR34280936_k127_786152_51
Copper-binding protein
-
-
-
2.513e-289
898.0
SRR34280936_k127_786152_52
metallo-beta-lactamase
K12574
-
-
5.91e-287
889.0
SRR34280936_k127_786152_53
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K00764
-
2.4.2.14
3.319e-286
901.0
SRR34280936_k127_786152_54
Penicillin-binding Protein
K05515
-
3.4.16.4
7.462e-284
884.0
SRR34280936_k127_786152_55
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
3.139e-282
874.0
SRR34280936_k127_786152_56
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K00335
-
1.6.5.3
1.044e-280
863.0
SRR34280936_k127_786152_57
membrane metal-binding protein
K02238
-
-
1.321e-277
872.0
SRR34280936_k127_786152_58
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00333
-
1.6.5.3
2.362e-277
852.0
SRR34280936_k127_786152_59
COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
K00382
-
1.8.1.4
4.176e-276
853.0
SRR34280936_k127_786152_6
TonB dependent receptor
-
-
-
0.0
1639.0
SRR34280936_k127_786152_60
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
1.37e-274
861.0
SRR34280936_k127_786152_61
NADH ubiquinone oxidoreductase subunit
K00342
-
1.6.5.3
1.163e-273
850.0
SRR34280936_k127_786152_62
peptidylprolyl isomerase
K01802,K03770
-
5.2.1.8
7.262e-269
842.0
SRR34280936_k127_786152_63
Protein of unknown function (DUF3604)
-
-
-
1.992e-268
839.0
SRR34280936_k127_786152_64
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
1.477e-264
817.0
SRR34280936_k127_786152_65
Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
-
-
-
1.535e-264
822.0
SRR34280936_k127_786152_66
Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K04094
-
2.1.1.74
1.839e-264
820.0
SRR34280936_k127_786152_67
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
1.561e-259
803.0
SRR34280936_k127_786152_7
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1585.0
SRR34280936_k127_786152_70
acyl-CoA dehydrogenase
-
-
-
2.325e-258
797.0
SRR34280936_k127_786152_71
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01657
-
4.1.3.27
6.332e-257
799.0
SRR34280936_k127_786152_72
amidohydrolase
-
-
-
2.229e-256
797.0
SRR34280936_k127_786152_73
Belongs to the citrate synthase family
K01647
-
2.3.3.1
2.838e-256
793.0
SRR34280936_k127_786152_74
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
6.649e-256
803.0
SRR34280936_k127_786152_75
Acts as a magnesium transporter
K06213
-
-
1.076e-255
794.0
SRR34280936_k127_786152_76
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
1.824e-255
792.0
SRR34280936_k127_786152_77
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
1.263e-254
789.0
SRR34280936_k127_786152_78
Saccharopine dehydrogenase
K00290
-
1.5.1.7
6.149e-254
788.0
SRR34280936_k127_786152_79
Belongs to the GSP D family
K02280
-
-
1.381e-253
789.0
SRR34280936_k127_786152_8
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K01952
-
6.3.5.3
0.00000000000000000000000000000000000000000007043
162.0
SRR34280936_k127_829481_143
-
-
-
-
0.000000000000000000000000000000000000000001288
169.0
SRR34280936_k127_829481_144
NLP P60 protein
-
-
-
0.000000000000000000000000000000000000000006728
157.0
SRR34280936_k127_829481_145
Belongs to the ompA family
K03286
-
-
0.00000000000000000000000000000000000000001151
160.0
SRR34280936_k127_829481_146
Belongs to the HesB IscA family
-
-
-
0.00000000000000000000000000000000000000001812
158.0
SRR34280936_k127_829481_147
acyl carrier protein
-
-
-
0.00000000000000000000000000000000000000006363
153.0
SRR34280936_k127_829481_148
-
-
-
-
0.00000000000000000000000000000000000000009196
153.0
SRR34280936_k127_829481_149
-
-
-
-
0.0000000000000000000000000000000000000003398
153.0
SRR34280936_k127_829481_15
COG0729 Outer membrane protein
K07278
-
-
3.077e-263
829.0
SRR34280936_k127_829481_150
Phage tail tube protein, GTA-gp10
-
-
-
0.0000000000000000000000000000000000000006862
150.0
SRR34280936_k127_829481_151
Protein of unknown function (DUF3168)
-
-
-
0.000000000000000000000000000000000000001189
154.0
SRR34280936_k127_829481_153
Domain of unknown function (DUF4154)
-
-
-
0.00000000000000000000000000000000000001715
151.0
SRR34280936_k127_829481_154
Domain of unknown function (DUF4281)
-
-
-
0.0000000000000000000000000000000000002036
146.0
SRR34280936_k127_829481_155
-
-
-
-
0.000000000000000000000000000000000002553
141.0
SRR34280936_k127_829481_156
Bacterial regulatory proteins, tetR family
-
-
-
0.00000000000000000000000000000000000381
146.0
SRR34280936_k127_829481_157
-
-
-
-
0.000000000000000000000000000000000007507
143.0
SRR34280936_k127_829481_158
-
-
-
-
0.000000000000000000000000000000002128
134.0
SRR34280936_k127_829481_159
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.0000000000000000000000000000001014
132.0
SRR34280936_k127_829481_16
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
7.711e-260
805.0
SRR34280936_k127_829481_160
Helix-turn-helix XRE-family like proteins
K07729
-
-
0.0000000000000000000000000000002682
123.0
SRR34280936_k127_829481_161
-
-
-
-
0.00000000000000000000000000005618
121.0
SRR34280936_k127_829481_162
-
-
-
-
0.0000000000000000000000000007168
119.0
SRR34280936_k127_829481_163
Protein of unknown function (DUF1295)
-
-
-
0.00000000000000000000000001135
119.0
SRR34280936_k127_829481_164
Flavin reductase like domain
-
-
-
0.00000000000000000000002146
106.0
SRR34280936_k127_829481_165
-
-
-
-
0.000000000000000000001468
96.0
SRR34280936_k127_829481_167
Phage tail assembly chaperone protein, TAC
-
-
-
0.00000000000000001709
85.0
SRR34280936_k127_829481_169
-
-
-
-
0.0000000000000000753
83.0
SRR34280936_k127_829481_17
Protein tyrosine kinase
K12132
-
2.7.11.1
9.962e-252
806.0
SRR34280936_k127_829481_170
BFD-like [2Fe-2S] binding domain
K02192
-
-
0.0000000000000003992
79.0
SRR34280936_k127_829481_173
Belongs to the sulfur carrier protein TusA family
K04085
-
-
0.00000000000002011
75.0
SRR34280936_k127_829481_174
COG2801 Transposase and inactivated derivatives
-
-
-
0.0000000000001116
70.0
SRR34280936_k127_829481_178
COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
-
-
-
0.0000008887
57.0
SRR34280936_k127_829481_179
Bacterial regulatory proteins, luxR family
-
-
-
0.000001204
58.0
SRR34280936_k127_829481_18
Belongs to the peptidase S41A family
K03797
-
3.4.21.102
3.624e-251
779.0
SRR34280936_k127_829481_180
membrane
-
-
-
0.000004244
53.0
SRR34280936_k127_829481_182
Aminoglycoside phosphotransferase
-
-
-
0.00001126
49.0
SRR34280936_k127_829481_19
COG0156 7-keto-8-aminopelargonate synthetase and related enzymes
COG3307 Lipid A core - O-antigen ligase and related enzymes
-
-
-
6.563e-242
754.0
SRR34280936_k127_829481_25
Pyrrolo-quinoline quinone
-
-
-
4.401e-228
712.0
SRR34280936_k127_829481_26
Polysaccharide biosynthesis protein
-
-
-
2.586e-220
695.0
SRR34280936_k127_829481_27
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03040
-
2.7.7.6
6.476e-219
682.0
SRR34280936_k127_829481_28
Belongs to the thiolase family
K00626,K00632
-
2.3.1.16,2.3.1.9
7.934e-219
684.0
SRR34280936_k127_829481_29
modulator of DNA gyrase
K03592
-
-
1.783e-218
684.0
SRR34280936_k127_829481_3
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K01952
-
6.3.5.3
0.0
1409.0
SRR34280936_k127_829481_30
Na -driven multidrug efflux pump
K03327
-
-
1.644e-216
680.0
SRR34280936_k127_829481_31
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
2.345e-215
672.0
SRR34280936_k127_829481_32
YjgP YjgQ family
K07091
-
-
8.72e-215
671.0
SRR34280936_k127_829481_33
Glycosyl transferase
-
-
-
3.344e-213
667.0
SRR34280936_k127_829481_34
acetyltransferase
-
-
-
3.31e-208
651.0
SRR34280936_k127_829481_35
AFG1 family ATPase
K06916
-
-
1.954e-205
642.0
SRR34280936_k127_829481_36
Terminase RNaseH-like domain
-
-
-
1.348e-203
641.0
SRR34280936_k127_829481_37
phage phi-C31 gp36 major capsid-like protein
-
-
-
8.705e-200
627.0
SRR34280936_k127_829481_38
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
K00658
-
2.3.1.61
3.048e-198
624.0
SRR34280936_k127_829481_39
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
1.446e-196
620.0
SRR34280936_k127_829481_4
Belongs to the peptidase M16 family
K07263
-
-
0.0
1377.0
SRR34280936_k127_829481_40
Methionine synthase I (cobalamin-dependent), methyltransferase domain
K00548
-
2.1.1.13
3.888e-196
615.0
SRR34280936_k127_829481_41
portal protein
-
-
-
3.381e-195
613.0
SRR34280936_k127_829481_42
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K03979
-
-
6.217e-195
610.0
SRR34280936_k127_829481_43
Catalyzes the reversible oxidation of malate to oxaloacetate
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
K00982
-
2.7.7.42,2.7.7.89
0.0
1295.0
SRR34280936_k127_829481_50
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
-
-
-
0.0
1106.0
SRR34280936_k127_829481_80
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
COG1629 Outer membrane receptor proteins, mostly Fe transport
-
-
-
0.0
1167.0
SRR34280936_k127_920991_170
This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1585.0
SRR34280936_k127_920991_20
Penicillin-Binding Protein C-terminus Family
K05367
-
2.4.1.129
0.0
1103.0
SRR34280936_k127_920991_200
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
K02892
-
-
0.00000000000000000000000000000000000000000001953
163.0
SRR34280936_k127_920991_246
-
-
-
-
0.0000000000000000000000000000000000000000001372
163.0
SRR34280936_k127_920991_247
-
-
-
-
0.000000000000000000000000000000000000000173
153.0
SRR34280936_k127_920991_248
transcriptional regulator, luxR family
-
-
-
0.0000000000000000000000000000000000000003149
160.0
SRR34280936_k127_920991_249
Could be involved in insertion of integral membrane proteins into the membrane
K08998
-
-
0.000000000000000000000000000000000000008327
146.0
SRR34280936_k127_920991_25
COG1629 Outer membrane receptor proteins, mostly Fe transport
-
-
-
3.742e-314
976.0
SRR34280936_k127_920991_250
-
-
-
-
0.00000000000000000000000000000000000001148
147.0
SRR34280936_k127_920991_251
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K03642
-
-
0.00000000000000000000000000000000000002637
150.0
SRR34280936_k127_920991_252
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K02895
-
-
0.00000000000000000000000000000000000006655
146.0
SRR34280936_k127_920991_254
conserved small protein
K07497
-
-
0.0000000000000000000000000000000000006455
139.0
SRR34280936_k127_920991_255
Protein of unknown function (DUF1491)
-
-
-
0.000000000000000000000000000000000001314
141.0
SRR34280936_k127_920991_256
Binds directly to 16S ribosomal RNA
K02968
-
-
0.00000000000000000000000000000000003337
141.0
SRR34280936_k127_920991_258
Protein of unknown function (DUF1489)
-
-
-
0.0000000000000000000000000000000001087
138.0
SRR34280936_k127_920991_259
-
-
-
-
0.0000000000000000000000000000000003848
135.0
SRR34280936_k127_920991_26
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
K03495
-
-
9.769e-314
972.0
SRR34280936_k127_920991_260
Phosphoribosyl-ATP
K01523
-
3.6.1.31
0.0000000000000000000000000000000009349
136.0
SRR34280936_k127_920991_261
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.000000000000000000000000000000004528
134.0
SRR34280936_k127_920991_262
Fe2 transport system protein A
K04758
-
-
0.0000000000000000000000000000004831
124.0
SRR34280936_k127_920991_263
GtrA-like protein
-
-
-
0.0000000000000000000000000000006076
127.0
SRR34280936_k127_920991_264
-
-
-
-
0.000000000000000000000000000005762
124.0
SRR34280936_k127_920991_265
Ribosomal protein L30
K02907
-
-
0.00000000000000000000000000001105
118.0
SRR34280936_k127_920991_266
Uncharacterized protein conserved in bacteria (DUF2093)
-
-
-
0.00000000000000000000000000002266
117.0
SRR34280936_k127_920991_267
-
-
-
-
0.00000000000000000000000000003653
122.0
SRR34280936_k127_920991_268
Belongs to the universal ribosomal protein uL29 family
K02904
-
-
0.000000000000000000000000001611
113.0
SRR34280936_k127_920991_269
Domain of unknown function (DUF4287)
-
-
-
0.0000000000000000000000001977
108.0
SRR34280936_k127_920991_27
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K01916
-
6.3.1.5
1.306e-303
936.0
SRR34280936_k127_920991_270
Protein of unknown function (DUF3572)
-
-
-
0.0000000000000000000000008046
107.0
SRR34280936_k127_920991_271
Belongs to the bacterial ribosomal protein bL33 family
Belongs to the bacterial ribosomal protein bL36 family
K02919
-
-
0.000000000000001359
78.0
SRR34280936_k127_920991_275
Bacterial PH domain
K08981
-
-
0.0000000000003947
70.0
SRR34280936_k127_920991_276
-
-
-
-
0.0000000157
58.0
SRR34280936_k127_920991_28
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K03688
-
-
3.671e-298
921.0
SRR34280936_k127_920991_29
Thi4 family
-
-
-
6.025e-298
921.0
SRR34280936_k127_920991_3
Belongs to the class-I aminoacyl-tRNA synthetase family
K01869
-
6.1.1.4
0.0
1565.0
SRR34280936_k127_920991_30
Belongs to the glutamate synthase family
-
-
-
5.452e-297
917.0
SRR34280936_k127_920991_31
ATPase with chaperone activity
K07391
-
-
1.922e-287
889.0
SRR34280936_k127_920991_32
glutamate--cysteine ligase
K01919
-
6.3.2.2
2.293e-283
872.0
SRR34280936_k127_920991_33
amino acid
K03294
-
-
1.695e-274
851.0
SRR34280936_k127_920991_34
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
2.299e-264
822.0
SRR34280936_k127_920991_35
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
4.224e-264
816.0
SRR34280936_k127_920991_36
Putative Flp pilus-assembly TadE/G-like
-
-
-
1.08e-263
830.0
SRR34280936_k127_920991_37
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
2.167e-262
819.0
SRR34280936_k127_920991_38
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
2.397e-260
806.0
SRR34280936_k127_920991_39
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K14652
-
3.5.4.25,4.1.99.12
1.669e-253
784.0
SRR34280936_k127_920991_4
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.0
1541.0
SRR34280936_k127_920991_40
phosphomannomutase
K01840
-
5.4.2.8
1.425e-252
784.0
SRR34280936_k127_920991_41
protein-S-isoprenylcysteine methyltransferase
-
-
-
4.173e-251
780.0
SRR34280936_k127_920991_42
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
5.123e-249
770.0
SRR34280936_k127_920991_43
Domain of unknown function DUF11
-
-
-
4.801e-245
773.0
SRR34280936_k127_920991_44
cytochrome P450
-
-
-
2.587e-241
749.0
SRR34280936_k127_920991_45
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
1.724e-239
745.0
SRR34280936_k127_920991_46
Polysaccharide biosynthesis protein
-
-
-
7.475e-239
747.0
SRR34280936_k127_920991_47
acyl-CoA dehydrogenase
K00252
-
1.3.8.6
7.124e-235
729.0
SRR34280936_k127_920991_48
nucleoside
K03317
-
-
1.064e-230
720.0
SRR34280936_k127_920991_49
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
4.708e-229
719.0
SRR34280936_k127_920991_5
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1491.0
SRR34280936_k127_920991_50
COG1228 Imidazolonepropionase and related amidohydrolases
-
-
-
5.455e-227
708.0
SRR34280936_k127_920991_51
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03092
-
-
3.185e-224
703.0
SRR34280936_k127_920991_52
protein conserved in bacteria
-
-
-
2.611e-221
703.0
SRR34280936_k127_920991_53
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03601
-
3.1.11.6
6.573e-219
693.0
SRR34280936_k127_920991_54
COG1253 Hemolysins and related proteins containing CBS domains
K03699
-
-
1.078e-215
678.0
SRR34280936_k127_920991_55
protein conserved in bacteria
K09919
-
-
7.322e-206
644.0
SRR34280936_k127_920991_56
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01439
-
3.5.1.18
2.047e-204
640.0
SRR34280936_k127_920991_57
NADH flavin
-
-
-
3.814e-204
639.0
SRR34280936_k127_920991_58
COG1680 Beta-lactamase class C and other penicillin binding proteins
-
-
-
3.912e-202
637.0
SRR34280936_k127_920991_59
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K13038
-
4.1.1.36,6.3.2.5
2.035e-201
636.0
SRR34280936_k127_920991_6
COG1629 Outer membrane receptor proteins, mostly Fe transport
-
-
-
0.0
1443.0
SRR34280936_k127_920991_60
conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
-
-
-
1.392e-200
634.0
SRR34280936_k127_920991_61
Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K00641
-
2.3.1.31
1.797e-200
628.0
SRR34280936_k127_920991_62
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K01889
-
6.1.1.20
4.026e-199
625.0
SRR34280936_k127_920991_63
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
1.165e-196
619.0
SRR34280936_k127_920991_64
Major facilitator superfamily
K07552
-
-
2.383e-196
619.0
SRR34280936_k127_920991_65
in Escherichia coli this protein forms a dimer and binds manganese
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
