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Global Wetland Microbiome Database
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— Central carbohydrate metabolism —
M00001: Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00002: Glycolysis, core module involving three-carbon compounds
M00003: Gluconeogenesis, oxaloacetate => fructose-6P
M00307: Pyruvate oxidation, pyruvate => acetyl-CoA
M00009: Citrate cycle (TCA cycle, Krebs cycle)
M00010: Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
M00011: Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00004: Pentose phosphate pathway (Pentose phosphate cycle)
M00006: Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
M00007: Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P
M00580: Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
M00005: PRPP biosynthesis, ribose 5P => PRPP
M00008: Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate
M00308: Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P
M00633: Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P
M00309: Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate
— Other carbohydrate metabolism —
M00014: Glucuronate pathway (uronate pathway)
M00630: D-Galacturonate degradation (fungi), D-galacturonate => glycerol
M00631: D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P
M00061: D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P
M00081: Pectin degradation
M00632: Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P
M00552: D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P
M00129: Ascorbate biosynthesis, animals, glucose-1P => ascorbate
M00114: Ascorbate biosynthesis, plants, fructose-6P => ascorbate
M00550: Ascorbate degradation, ascorbate => D-xylulose-5P
M00854: Glycogen biosynthesis, glucose-1P => glycogen/starch
M00855: Glycogen degradation, glycogen => glucose-6P
M00565: Trehalose biosynthesis, D-glucose 1P => trehalose
M00012: Glyoxylate cycle
M00373: Ethylmalonyl pathway
M00740: Methylaspartate cycle
M00532: Photorespiration
M00013: Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
M00741: Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA
M00982: Methylcitrate cycle
M00968: Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate
M00130: Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
M00131: Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
M00132: Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate
— Carbon fixation —
M00165: Reductive pentose phosphate cycle (Calvin cycle)
M00168: CAM (Crassulacean acid metabolism), dark
M00169: CAM (Crassulacean acid metabolism), light
M00172: C4-dicarboxylic acid cycle, NADP - malic enzyme type
M00171: C4-dicarboxylic acid cycle, NAD - malic enzyme type
M00170: C4-dicarboxylic acid cycle, phosphoenolpyruvate carboxykinase type
M00173: Reductive citrate cycle (Arnon-Buchanan cycle)
M00376: 3-Hydroxypropionate bi-cycle
M00375: Hydroxypropionate-hydroxybutylate cycle
M00374: Dicarboxylate-hydroxybutyrate cycle
M00377: Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)
M00579: Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate
M00620: Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate
— Methane metabolism —
M00567: Methanogenesis, CO2 => methane
M00357: Methanogenesis, acetate => methane
M00356: Methanogenesis, methanol => methane
M00563: Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
M00358: Coenzyme M biosynthesis
M00608: 2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
M00174: Methane oxidation, methanotroph, methane => formaldehyde
M00346: Formaldehyde assimilation, serine pathway
M00345: Formaldehyde assimilation, ribulose monophosphate pathway
M00344: Formaldehyde assimilation, xylulose monophosphate pathway
M00378: F420 biosynthesis, archaea
M00935: Methanofuran biosynthesis
M00422: Acetyl-CoA pathway, CO2 => acetyl-CoA
— Nitrogen metabolism —
M00175: Nitrogen fixation, nitrogen => ammonia
M00531: Assimilatory nitrate reduction, nitrate => ammonia
M00530: Dissimilatory nitrate reduction, nitrate => ammonia
M00529: Denitrification, nitrate => nitrogen
M00528: Nitrification, ammonia => nitrite
M00804: Complete nitrification, comammox, ammonia => nitrite => nitrate
M00973: Anammox, nitrite + ammonia => nitrogen
— Sulfur metabolism —
M00987: Assimilatory sulfate reduction, plants, sulfate => H2S
M00176: Assimilatory sulfate reduction, sulfate => H2S
M00596: Dissimilatory sulfate reduction, sulfate => H2S
M00595: Sulfur oxidation, SOX system, thiosulfate => sulfate
M00984: Sulfur oxidation, tetrathionate intermediate (S4I) pathway, thiosulfate => sulfur + sulfate + thiosulfate
M00986: Sulfur reduction, sulfur => sulfide
M00985: Sulfide oxidation, sulfide => sulfur
M00990: Dimethylsulfoniopropionate (DMSP) degradation, demethylation pathway, DMSP => methanethiol
M00991: Dimethylsulfoniopropionate (DMSP) degradation, cleavage pathway, DMSP => acetyl-CoA
M00992: Dimethylsulfoniopropionate (DMSP) degradation, cleavage pathway, DMSP => acrylate => acetyl-CoA
M00993: Dimethylsulfoniopropionate (DMSP) degradation, cleavage pathway, DMSP => propionyl-CoA
— Photosynthesis —
M00161: Photosystem II
M00163: Photosystem I
M00597: Anoxygenic photosystem II
M00598: Anoxygenic photosystem I
— ATP synthesis —
M00144: NADH:quinone oxidoreductase, prokaryotes
M00145: NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria
M00142: NADH:ubiquinone oxidoreductase, mitochondria
M00143: NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria
M00146: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex
M00147: NADH dehydrogenase (ubiquinone) 1 beta subcomplex
M00149: Succinate dehydrogenase, prokaryotes
M00150: Fumarate reductase, prokaryotes
M00148: Succinate dehydrogenase (ubiquinone)
M00162: Cytochrome b6f complex
M00151: Cytochrome bc1 complex respiratory unit
M00152: Cytochrome bc1 complex
M00154: Cytochrome c oxidase
M00155: Cytochrome c oxidase, prokaryotes
M00153: Cytochrome bd ubiquinol oxidase
M00417: Cytochrome o ubiquinol oxidase
M00416: Cytochrome aa3-600 menaquinol oxidase
M00156: Cytochrome c oxidase, cbb3-type
M00157: F-type ATPase, prokaryotes and chloroplasts
M00158: F-type ATPase, eukaryotes
M00159: V/A-type ATPase, prokaryotes
M00160: V-type ATPase, eukaryotes
— Fatty acid metabolism —
M00082: Fatty acid biosynthesis, initiation
M00083: Fatty acid biosynthesis, elongation
M00873: Fatty acid biosynthesis in mitochondria, animals
M00874: Fatty acid biosynthesis in mitochondria, fungi
M00085: Fatty acid elongation in mitochondria
M00415: Fatty acid elongation in endoplasmic reticulum
M00086: beta-Oxidation, acyl-CoA synthesis
M00087: beta-Oxidation
M00861: beta-Oxidation, peroxisome, VLCFA
M00885: Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)
M00886: Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
M00887: Mycolic acid biosynthesis, meromycolic acid + alpha-carboxyacyl-CoA + trehalose => TMM => TDM/mAGP/GMM
— Sterol biosynthesis —
M00101: Cholesterol biosynthesis, FPP => cholesterol
M00102: Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
M00917: Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
M00103: Cholecalciferol biosynthesis
M00104: Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
M00106: Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate
M00862: beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA
M00107: Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
M00108: C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109: C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
M00110: C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
M00976: C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
M00977: C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
— Lipid metabolism —
M00088: Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
M00089: Triacylglycerol biosynthesis
M00098: Acylglycerol degradation
M00090: Phosphatidylcholine (PC) biosynthesis, choline => PC
M00091: Phosphatidylcholine (PC) biosynthesis, PE => PC
M00092: Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE
M00093: Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE
M00094: Ceramide biosynthesis
M00066: Lactosylceramide biosynthesis
M00067: Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid
M00099: Sphingosine biosynthesis
M00100: Sphingosine degradation
M00113: Jasmonic acid biosynthesis
— Purine metabolism —
M00048: De novo purine biosynthesis, PRPP + glutamine => IMP
M00049: Adenine ribonucleotide biosynthesis, IMP => ADP,ATP
M00050: Guanine ribonucleotide biosynthesis, IMP => GDP,GTP
M00053: Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP
M00958: Adenine ribonucleotide degradation, AMP => Urate
M00959: Guanine ribonucleotide degradation, GMP => Urate
M00546: Purine degradation, xanthine => urea
— Pyrimidine metabolism —
M00051: De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
M00052: Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP
M00938: Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
M00046: Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
M00939: Pyrimidine degradation, uracil => 3-hydroxypropanoate
— Serine and threonine metabolism —
M00020: Serine biosynthesis, glycerate-3P => serine
M00018: Threonine biosynthesis, aspartate => homoserine => threonine
M00621: Glycine cleavage system
M00555: Betaine biosynthesis, choline => betaine
M00974: Betaine metabolism, animals, betaine => glycine
M00975: Betaine degradation, bacteria, betaine => pyruvate
M00033: Ectoine biosynthesis, aspartate => ectoine
M00919: Ectoine degradation, ectoine => aspartate
— Cysteine and methionine metabolism —
M00021: Cysteine biosynthesis, serine => cysteine
M00338: Cysteine biosynthesis, homocysteine + serine => cysteine
M00609: Cysteine biosynthesis, methionine => cysteine
M00017: Methionine biosynthesis, aspartate => homoserine => methionine
M00034: Methionine salvage pathway
M00035: Methionine degradation
M00368: Ethylene biosynthesis, methionine => ethylene
— Branched-chain amino acid metabolism —
M00019: Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine
M00535: Isoleucine biosynthesis, pyruvate => 2-oxobutanoate
M00570: Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine
M00432: Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
M00036: Leucine degradation, leucine => acetoacetate + acetyl-CoA
— Lysine metabolism —
M00016: Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
M00525: Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine
M00526: Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine
M00527: Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine
M00030: Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433: Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00031: Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine
M00032: Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00956: Lysine degradation, bacteria, L-lysine => succinate
M00957: Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA
M00960: Lysine degradation, bacteria, L-lysine => D-lysine => succinate
— Arginine and proline metabolism —
M00028: Ornithine biosynthesis, glutamate => ornithine
M00763: Ornithine biosynthesis, mediated by LysW, glutamate => ornithine
M00844: Arginine biosynthesis, ornithine => arginine
M00845: Arginine biosynthesis, glutamate => acetylcitrulline => arginine
M00029: Urea cycle
M00978: Ornithine-ammonia cycle
M00015: Proline biosynthesis, glutamate => proline
M00970: Proline degradation, proline => glutamate
M00972: Proline metabolism
M00047: Creatine pathway
M00879: Arginine succinyltransferase pathway, arginine => glutamate
— Polyamine biosynthesis —
M00133: Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine
M00134: Polyamine biosynthesis, arginine => ornithine => putrescine
M00135: GABA biosynthesis, eukaryotes, putrescine => GABA
M00136: GABA biosynthesis, prokaryotes, putrescine => GABA
— Histidine metabolism —
M00026: Histidine biosynthesis, PRPP => histidine
M00045: Histidine degradation, histidine => N-formiminoglutamate => glutamate
— Aromatic amino acid metabolism —
M00022: Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate
M00023: Tryptophan biosynthesis, chorismate => tryptophan
M00024: Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine
M00910: Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine
M00025: Tyrosine biosynthesis, chorismate => HPP => tyrosine
M00040: Tyrosine biosynthesis, chorismate => arogenate => tyrosine
M00042: Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
M00043: Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine
M00044: Tyrosine degradation, tyrosine => homogentisate
M00533: Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate
M00037: Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
M00936: Melatonin biosynthesis, plants, tryptophan => serotonin => melatonin
M00038: Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
— Other amino acid metabolism —
M00027: GABA (gamma-Aminobutyrate) shunt
M00369: Cyanogenic glycoside biosynthesis, tyrosine => dhurrin
M00118: Glutathione biosynthesis, glutamate => glutathione
M00947: D-Arginine racemization, D-arginine => L-arginine
M00948: Hydroxyproline degradation, trans-4-hydroxy-L-proline => 2-oxoglutarate
M00949: Staphylopine biosynthesis, L-histidine => staphylopine
— Nucleotide sugar biosynthesis —
M00892: UDP-GlcNAc biosynthesis, eukaryotes, Fru-6P => UDP-GlcNAc
M00909: UDP-GlcNAc biosynthesis, prokaryotes, Fru-6P => UDP-GlcNAc
M01003: UDP-GlcNAc biosynthesis, GlcNAc => UDP-GlcNAc
M01002: UDP-GalNAc biosynthesis, Fru-6P => UDP-GalNAc
M00996: UDP-MurNAc biosynthesis, anhMurNAc => UDP-MurNAc
M00995: UDP-MurNAc biosynthesis, Fru-6P => UDP-MurNAc
M00549: UDP-Glc biosynthesis, Glc => UDP-Glc
M01004: UDP-Galf biosynthesis, UDP-Glc => UDP-Galf
M00998: UDP-L-Ara biosynthesis, L-Ala => UDP-L-Ala
M00997: UDP-Xyl/L-Ara biosynthesis, UDP-Glc => UDP-Xyl => UDP-L-Ala
M00994: UDP-GlcA biosynthesis, myo-inositol => GlcA => UDP-GlcA
M00999: UDP-GlcA/GalA biosynthesis, UDP-Glc => UDP-GlcA => UDP-GalA
M00554: UDP-Gal biosynthesis, Gal => UDP-Gal
M01000: GDP-Man biosynthesis, Fru-6P => GDP-Man
M01015: GDP-Man biosynthesis, Man => GDP-Man
M01001: GDP-L-Fuc biosynthesis, L-Fuc => GDP-L-Fuc
M01036: UDP-GalNAcA biosynthesis, UDP-GlcNAc => UDP-GalNAcA
M01035: UDP-ManNAc3NAcA biosynthesis, UDP-GlcNAc => UDP-ManNAc3NAcA
M01005: UDP-XylNAc biosynthesis, UDP-GlcNAc => UDP-XylNAc
M00923: UDP-L-FucNAc biosynthesis, UDP-GlcNAc => UDP-L-FucNAc
M01007: CMP-Pse5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-Pse5Ac7Ac
M01008: CMP-8eLeg5Ac7Ac biosynthesis, UDP-GlcNAc => CMP-8eLeg5Ac7Ac
M01009: UDP-QuiNAc biosynthesis, UDP-GlcNAc => UDP-QuiNAc
M01032: UDP-D-FucNAc biosynthesis, UDP-GlcNAc => UDP-D-FucNAc
M01033: UDP-yelosamine biosynthesis, UDP-GlcNAc => UDP-yelosamine
M01037: UDP-D-FucNAc4N biosynthesis, UDP-GlcNAc => UDP-D-FucNAc4N
M01010: UDP-BacNAc4NAc biosynthesis, UDP-GlcNAc => UDP-BacNAc4NAc
M01011: CMP-Leg5Ac7Ac biosynthesis, UDP-BacNAc4NAc => CMP-Leg5Ac7Ac
M01012: CMP-Leg5Ac7Ala biosynthesis, UDP-GlcNAc => CMP-Leg5Ac7Ala
M00954: CMP-KDN biosynthesis, Man-6P => CMP-KDN
M00063: CMP-KDO biosynthesis, ribulose-5P => CMP-KDO
M00922: CMP-Neu5Ac biosynthesis, bacteria, UDP-GlcNAc => CMP-Neu5Ac
M00955: CMP-Neu5Ac/Neu5Gc biosynthesis, animals, UDP-GlcNAc => CMP-Neu5Ac => CMP-Neu5Gc
M01014: UDP-ManNAcA biosynthesis, UDP-GlcNAc => UDP-ManNAcA
M01028: GDP-DDmanHep biosynthesis, sedoheptulose-7P => GDP-DDmanHep
M00064: ADP-LDmanHep biosynthesis, sedoheptulose-7P => ADP-LDmanHep
M01021: UDP-L-Rha biosynthesis, UDP-Glc => UDP-L-Rha
M00761: Und-P-alpha-L-Ara4N biosynthesis, UDP-Glc => UDP-L-Ara4FN => Und-P-alpha-L-Ara4N
M01029: CDP-Tyv biosynthesis, Glc-1P => CDP-Par => CDP-Tyv
M01030: CDP-Abe biosynthesis, Glc-1P => CDP-Abe
M01031: CDP-Asc biosynthesis, Glc-1P => CDP-Asc
M00793: dTDP-L-Rha biosynthesis, Glc-1P => dTDP-L-Rha
M01022: dTDP-6-deoxy-L-Tal biosynthesis, Glc-1P => dTDP-6-deoxy-L-Tal
M01023: dTDP-D-Fuc3NAc biosynthesis, Glc-1P => dTDP-D-Fuc3NAc
M01024: dTDP-Qui3NAc biosynthesis, Glc-1P => dTDP-Qui3NAc
M01025: dTDP-D-Fuc4NAc biosynthesis, Glc-1P => dTDP-D-Fuc4NAc
M01026: dTDP-Qui4NAc biosynthesis, Glc-1P => dTDP-Qui4NAc
M01027: dTDP-D-Fucf biosynthesis, Glc-1P => dTDP-D-Fucf
M01006: GDP-D-Rha4N biosynthesis, Fru-6P => GDP-D-Rha4N
M01034: GDP-D-Rha4NFormyl biosynthesis, GDP-Man => GDP-D-Rha4N => GDP-D-Rha4NFormyl
M01020: GDP-D-Rha4NAc biosynthesis, GDP-Man => GDP-D-Rha4N => GDP-D-Rha4NAc
M01016: GDP-L-Fuc biosynthesis, GDP-Man => GDP-L-Fuc
M01017: GDP-L-Col biosynthesis, GDP-Man => GDP-L-Col
M01018: GDP-D-Rha biosynthesis, GDP-Man => GDP-D-Rha
M01019: GDP-6-deoxy-Tal biosynthesis, GDP-Man => GDP-6-deoxy-Tal
— Glycan biosynthesis —
M00055: N-glycan precursor biosynthesis
M00072: N-glycosylation by oligosaccharyltransferase
M00073: N-glycan precursor trimming
M00074: N-glycan biosynthesis, high-mannose type
M00075: N-glycan biosynthesis, complex type
M00056: O-glycan biosynthesis, mucin type core
M00872: O-glycan biosynthesis, mannose type (core M3)
M00065: GPI-anchor biosynthesis, core oligosaccharide
M00983: GPI-anchor remodeling
M00070: Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer
M00071: Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer
M00068: Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer
M00069: Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3
— Glycosaminoglycan metabolism —
M00057: Glycosaminoglycan biosynthesis, linkage tetrasaccharide
M00058: Glycosaminoglycan biosynthesis, chondroitin sulfate backbone
M00059: Glycosaminoglycan biosynthesis, heparan sulfate backbone
M00076: Dermatan sulfate degradation
M00077: Chondroitin sulfate degradation
M00078: Heparan sulfate degradation
M00079: Keratan sulfate degradation
— Lipopolysaccharide metabolism —
M00060: KDO2-lipid A biosynthesis, Raetz pathway, LpxL-LpxM type
M00866: KDO2-lipid A biosynthesis, Raetz pathway, non-LpxL-LpxM type
M00867: KDO2-lipid A modification pathway
— Other polysaccharide metabolism —
M00888: Galactofuranan biosynthesis, decaprenyl phosphate + UDP-GlcNAc (+ dTDP-Rha/UDP-Galf) => GL-5
— Cofactor and vitamin metabolism —
M00127: Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP
M00895: Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP
M00896: Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
M00897: Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP
M00898: Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP
M00899: Thiamine salvage pathway, HMP/HET => TMP
M00125: Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD
M00911: Riboflavin biosynthesis, fungi, GTP => riboflavin/FMN/FAD
M00124: Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P
M00916: Pyridoxal-P biosynthesis, R5P + glyceraldehyde-3P + glutamine => pyridoxal-P
M00115: NAD biosynthesis, aspartate => quinolinate => NAD
M00912: NAD biosynthesis, tryptophan => quinolinate => NAD
M00810: Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde
M00811: Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde
M00622: Nicotinate degradation, nicotinate => fumarate
M00119: Pantothenate biosynthesis, valine/L-aspartate => pantothenate
M00913: Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate
M00120: Coenzyme A biosynthesis, pantothenate => CoA
M00914: Coenzyme A biosynthesis, archaea, 2-oxoisovalerate => 4-phosphopantoate => CoA
M00572: Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP
M00123: Biotin biosynthesis, pimeloyl-ACP/CoA => biotin
M00950: Biotin biosynthesis, BioU pathway, pimeloyl-ACP/CoA => biotin
M00573: Biotin biosynthesis, BioI pathway, long-chain-acyl-ACP => pimeloyl-ACP => biotin
M00577: Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin
M00881: Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H
M00882: Lipoic acid biosynthesis, eukaryotes, octanoyl-ACP => dihydrolipoyl-H
M00883: Lipoic acid biosynthesis, animals and bacteria, octanoyl-ACP => dihydrolipoyl-H => dihydrolipoyl-E2
M00884: Lipoic acid biosynthesis, octanoyl-CoA => dihydrolipoyl-E2
M00126: Tetrahydrofolate biosynthesis, GTP => THF
M00840: Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF
M00841: Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00842: Tetrahydrobiopterin biosynthesis, GTP => BH4
M00843: L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
M00880: Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor
M00988: PreQ1 biosynthesis, GTP => 7-Aminomethyl-7-deazaguanine
M00140: C1-unit interconversion, prokaryotes
M00141: C1-unit interconversion, eukaryotes
M00846: Siroheme biosynthesis, glutamyl-tRNA => siroheme
M00868: Heme biosynthesis, animals and fungi, glycine => heme
M00121: Heme biosynthesis, plants and bacteria, glutamate => heme
M00926: Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
M00847: Heme biosynthesis, archaea, siroheme => heme
M00924: Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
M00925: Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
M00122: Cobalamin biosynthesis, cobyrinate a,c-diamide => cobalamin
M00836: Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
M00117: Ubiquinone biosynthesis, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol
M00989: Ubiquinone biosynthesis, O2-independent, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol
M00128: Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate + polyprenyl-PP => ubiquinone
M00116: Menaquinone biosynthesis, chorismate (+ polyprenyl-PP) => menaquinol
M00930: Menaquinone biosynthesis, futalosine pathway
M00931: Menaquinone biosynthesis, modified futalosine pathway
M00932: Phylloquinone biosynthesis, chorismate (+ phytyl-PP) => phylloquinol
M00112: Tocopherol/tocotorienol biosynthesis, homogentisate + phytyl/geranylgeranyl-PP => tocopherol/tocotorienol
M00933: Plastoquinone biosynthesis, homogentisate + solanesyl-PP => plastoquinol
— Terpenoid backbone biosynthesis —
M00095: C5 isoprenoid biosynthesis, mevalonate pathway
M00849: C5 isoprenoid biosynthesis, mevalonate pathway, archaea
M00096: C5 isoprenoid biosynthesis, non-mevalonate pathway
M00364: C10-C20 isoprenoid biosynthesis, bacteria
M00365: C10-C20 isoprenoid biosynthesis, archaea
M00366: C10-C20 isoprenoid biosynthesis, plants
M00367: C10-C20 isoprenoid biosynthesis, non-plant eukaryotes
— Terpenoid biosynthesis —
M01038: Staphyloxanthin biosynthesis, bacteria, farnesyl-PP => staphyloxanthin
M00097: Lycopene biosynthesis, geranylgeranyl-PP => lycopene
M01039: Spirilloxanthin biosynthesis, bacteria, lycopene => spirilloxanthin
M01040: Lutein biosynthesis, plants, lycopene => lutein
M01041: Bacterioruberin biosynthesis, archaea, lycopene => bacterioruberin
M01042: Neurosporaxanthin biosynthesis, fungi, lycopene => neurosporaxanthin
M01043: Okenone biosynthesis, bacteria, lycopene => okenone
M01045: Zeaxanthin biosynthesis, lycopene => beta-carotene => zeaxanthin
M01046: Xanthophyll cycle
M00372: Abscisic acid biosynthesis, plants, 9'-cis-neoxanthin/9-cis-violaxanthin => abscisic acid
M01044: Astaxanthin biosynthesis, beta-carotene => astaxanthin
M00371: Castasterone biosynthesis, plants, campesterol => castasterone
M00927: Gibberellin A12 biosynthesis, plants, GAPP => GA12
M00928: Gibberellin A4/A1 biosynthesis, plants, GA12/GA53 => GA4/GA1
M00929: Gibberellin A1 biosynthesis, GGPP => GA1
— Macrolide biosynthesis —
M00773: Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
M00934: Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
M00774: Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
M00775: Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
M00776: Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
M00777: Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
— Enediyne biosynthesis —
M00824: 9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
M00825: 10-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 10-membered enediyne core
M00826: C-1027 benzoxazolinate moiety biosynthesis, chorismate => benzoxazolinyl-CoA
M00827: C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00828: Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP
M00829: 3,6-Dimethylsalicylyl-CoA biosynthesis, malonyl-CoA => 6-methylsalicylate => 3,6-dimethylsalicylyl-CoA
M00830: Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
M00831: Kedarcidin 2-hydroxynaphthoate moiety biosynthesis, malonyl-CoA => 3,6,8-trihydroxy-2-naphthoate => 3-hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA
M00832: Kedarcidin 2-aza-3-chloro-beta-tyrosine moiety biosynthesis, azatyrosine => 2-aza-3-chloro-beta-tyrosyl-PCP
M00834: Calicheamicin orsellinate moiety biosynthesis, malonyl-CoA => orsellinate-ACP => 5-iodo-2,3-dimethoxyorsellinate-ACP
M00833: Calicheamicin biosynthesis, calicheamicinone => calicheamicin
— Type II polyketide biosynthesis —
M00778: Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
M00779: Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
M00780: Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823: Chlortetracycline biosynthesis, pretetramide => chlortetracycline
M00781: Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
M00782: Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
M00783: Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
M00784: Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A
— Polyketide sugar unit biosynthesis —
M00794: dTDP-6-deoxy-D-allose biosynthesis
M00795: dTDP-beta-L-noviose biosynthesis
M00796: dTDP-D-mycaminose biosynthesis
M00797: dTDP-D-desosamine biosynthesis
M00798: dTDP-L-mycarose biosynthesis
M00799: dTDP-L-oleandrose biosynthesis
M00800: dTDP-L-megosamine biosynthesis
M00801: dTDP-L-olivose biosynthesis
M00802: dTDP-D-forosamine biosynthesis
M00803: dTDP-D-angolosamine biosynthesis
— Biosynthesis of phytochemical compounds —
M00039: Monolignol biosynthesis, phenylalanine/tyrosine => monolignol
M00137: Flavanone biosynthesis, phenylalanine => naringenin
M00940: Flavanone biosynthesis, p-coumaroyl-CoA => liquiritigenin
M00138: Flavonoid biosynthesis, naringenin => pelargonidin
M00941: Isoflavone biosynthesis, liquiritigenin/naringenin => daidzein/genistein
M00942: Pterocarpan biosynthesis, daidzein => medicarpin
M00966: Equol biosynthesis, daidzein => equol
M00967: Flavone degradation, luteolin/apigenin => DHCA/phloretate
M00962: Psilocybin biosynthesis, tryptophan => psilocybin
M00963: Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde
M00964: Fumigaclavine biosynthesis, chanoclavine-I aldehyde => fumigaclavine C
M00981: Geissoschizine biosynthesis, tryptophan => geissoschizine
M00979: Ajmaline biosynthesis, geissoschizine => ajmaline
M00980: Strychnine biosynthesis, geissoschizine => strychnine
M00965: Vinblastine biosynthesis, geissoschizine => vinblastine
M00943: Reticuline biosynthesis, dopamine + 4HPAA => (S)-reticuline
M00944: Morphine biosynthesis, (S)-reticuline => morphine
M00945: Sanguinarine biosynthesis, (S)-reticuline => sanguinarine
M00946: Noscapine biosynthesis, (S)-reticuline => noscapine
M00961: Betacyanin biosynthesis, L-tyrosine => amaranthin
M00370: Glucosinolate biosynthesis, tryptophan => glucobrassicin
M00900: Crocin biosynthesis, crocetin => crocin
M00971: QS-7 biosynthesis, 2,3-epoxysqualene => QS-7
M00894: Cannabidiol biosynthesis, malonyl-CoA => cannabidiol/dronabinol
M00953: Mugineic acid biosynthesis, methionine => 3-epihydroxymugineic acid
M00952: Benzoxazinoid biosynthesis, indoleglycerol phosphate => DIMBOA-glucoside
M00902: Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
— Biosynthesis of beta-lactams —
M00672: Penicillin biosynthesis, aminoadipate + cycteine + valine => penicillin
M00673: Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C
M00675: Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
M00736: Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A
M00674: Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate
— Biosynthesis of other antibiotics —
M00877: Kanosamine biosynthesis, glucose 6-phosphate => kanosamine
M00889: Puromycin biosynthesis, ATP => puromycin
M00815: Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A
M00904: Dapdiamides biosynthesis, L-2,3-diaminopropanoate => dapdiamide A/B/C
M00787: Bacilysin biosynthesis, prephenate => bacilysin
M00785: Cycloserine biosynthesis, arginine/serine => cycloserine
M00848: Aurachin biosynthesis, anthranilate => aurachin A
M00788: Terpentecin biosynthesis, GGAP => terpentecin
M00819: Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
M00903: Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin
M00890: Roseoflavin biosynthesis, FMN => roseoflavin
M00951: Cremeomycin biosynthesis, aspartate/3,4-AHBA => cremeomycin
M00969: Fumagillin biosynthesis, farnesyl-PP => fumagillin
— Biosynthesis of other fungal compounds —
M00661: Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
M00786: Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
M00937: Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
M00893: Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
M00891: Ditryptophenaline biosynthesis, tryptophan + phenylalanine => ditryptophenaline
M00901: Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
— Biosynthesis of other bacterial compounds —
M00814: Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose
M00789: Rebeccamycin biosynthesis, tryptophan => rebeccamycin
M00790: Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin
M00805: Staurosporine biosynthesis, tryptophan => staurosporine
M00808: Violacein biosynthesis, tryptophan => violacein
M00835: Pyocyanine biosynthesis, chorismate => pyocyanine
M00837: Prodigiosin biosynthesis, L-proline => prodigiosin
M00838: Undecylprodigiosin biosynthesis, L-proline => undecylprodigiosin
M00921: Cyclooctatin biosynthesis, dimethylallyl-PP + isopentenyl-PP => cyclooctatin
M00905: Grixazone biosynthesis, aspartate 4-semialdehyde => grixazone B
M00876: Staphyloferrin A biosynthesis, L-ornithine => staphyloferrin A
M00875: Staphyloferrin B biosynthesis, L-serine => staphyloferrin B
M00918: Aerobactin biosynthesis, lysine => aerobactin
M00906: Ethynylserine biosynthesis, lysine => ethynylserine
— Biosynthesis of other compounds —
M01047: Juvenile hormone biosynthesis, insects, farnesyl-PP => juvenile hormone III
M01013: Molting hormone biosynthesis, insects, 2,22,25-trideoxyecdysone => ecdysone => 20-hydroxyecdysone
— Aromatics degradation —
M00538: Toluene degradation, toluene => benzoate
M00537: Xylene degradation, xylene => methylbenzoate
M00419: Cymene degradation, p-cymene => p-cumate
M00547: Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol
M00548: Benzene degradation, benzene => catechol
M00551: Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol
M00637: Anthranilate degradation, anthranilate => catechol
M00568: Catechol ortho-cleavage, catechol => 3-oxoadipate
M00569: Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
M00539: Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate
M00543: Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate
M00544: Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate
M00418: Toluene degradation, anaerobic, toluene => benzoyl-CoA
M00541: Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
M00540: Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA
M00534: Naphthalene degradation, naphthalene => salicylate
M00638: Salicylate degradation, salicylate => gentisate
M00624: Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate
M00623: Phthalate degradation, phthalate => protocatechuate
M00636: Phthalate degradation, phthalate => protocatechuate
M00878: Phenylacetate degradation, phenylaxetate => acetyl-CoA/succinyl-CoA
M00545: Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
M00915: Caffeine degradation, caffeine => xanthine
— Pathogenicity —
M00852: Vibrio cholerae pathogenicity signature, toxin coregulated pilus
M00850: Vibrio cholerae pathogenicity signature, cholera toxins
M00542: EHEC/EPEC pathogenicity signature, T3SS and effectors
M00363: EHEC pathogenicity signature, Shiga toxin
M00853: ETEC pathogenicity signature, colonization factors
M00576: ETEC pathogenicity signature, heat-labile and heat-stable enterotoxins
M00856: Salmonella enterica pathogenicity signature, typhoid toxin
M00857: Salmonella enterica pathogenicity signature, Vi antigen
M00575: Pertussis pathogenicity signature, T1SS
M00574: Pertussis pathogenicity signature, pertussis toxin
M00564: Helicobacter pylori pathogenicity signature, cagA pathogenicity island
M00859: Bacillus anthracis pathogenicity signature, anthrax toxin
M00860: Bacillus anthracis pathogenicity signature, polyglutamic acid capsule biosynthesis
— Drug resistance —
M00851: Carbapenem resistance
M00625: Methicillin resistance
M00627: beta-Lactam resistance, Bla system
M00745: Imipenem resistance, repression of porin OprD
M00651: Vancomycin resistance, D-Ala-D-Lac type
M00652: Vancomycin resistance, D-Ala-D-Ser type
M00704: Tetracycline resistance, efflux pump Tet38
M00725: Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon
M00726: Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF
M00730: Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter
M00744: Cationic antimicrobial peptide (CAMP) resistance, protease PgtE
M00718: Multidrug resistance, efflux pump MexAB-OprM
M00639: Multidrug resistance, efflux pump MexCD-OprJ
M00641: Multidrug resistance, efflux pump MexEF-OprN
M00642: Multidrug resistance, efflux pump MexJK-OprM
M00643: Multidrug resistance, efflux pump MexXY-OprM
M00769: Multidrug resistance, efflux pump MexPQ-OpmE
M00649: Multidrug resistance, efflux pump AdeABC
M00696: Multidrug resistance, efflux pump AcrEF-TolC
M00697: Multidrug resistance, efflux pump MdtEF-TolC
M00698: Multidrug resistance, efflux pump BpeEF-OprC
M00700: Multidrug resistance, efflux pump AbcA
M00702: Multidrug resistance, efflux pump NorB
M00714: Multidrug resistance, efflux pump QacA
M00705: Multidrug resistance, efflux pump MepA
M00746: Multidrug resistance, repression of porin OmpF
— Plant pathogenicity —
M00660: Xanthomonas spp. pathogenicity signature, T3SS and effectors
— Symbiosis —
M00664: Nodulation
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