## Mon Feb 16 01:53:28 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/CH1_bin.41.fa -m mmseqs --output CH1_bin.41 --output_dir /data/result/bins/wyx/eggqs50+/CH1_bin.41 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CH1_k127_10353948_3	339860.Msp_1125	5.593e-09	66.0	COG1378@1|root,arCOG02037@2157|Archaea,2XZRE@28890|Euryarchaeota,23P59@183925|Methanobacteria	183925|Methanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
CH1_k127_10353948_5	118161.KB235922_gene5493	3.55e-05	51.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	HAMP,HATPase_c,HisKA,Response_reg,dCache_1
CH1_k127_10353948_2	694429.Pyrfu_1439	1.337e-15	81.0	COG2524@1|root,arCOG00610@2157|Archaea,2XPSP@28889|Crenarchaeota	28889|Crenarchaeota	K	signal transduction protein with CBS domains	-	-	-	ko:K07744	-	-	-	-	ko00000	-	-	-	CBS,HrcA_DNA-bdg
CH1_k127_10353948_0	269797.Mbar_A3243	1.869e-33	131.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
CH1_k127_10353948_4	1176165.CAJD01000022_gene1764	7.86e-08	59.0	COG0494@1|root,COG0494@2|Bacteria,2GNRV@201174|Actinobacteria,4F8BD@85019|Brevibacteriaceae	201174|Actinobacteria	L	Phosphoglycerate mutase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
CH1_k127_10353948_1	641107.CDLVIII_2007	6.64e-23	102.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,36EW0@31979|Clostridiaceae	186801|Clostridia	C	pyruvate flavodoxin ferredoxin oxidoreductase domain protein	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
CH1_k127_10416771_0	272844.PAB1128	2.118e-105	365.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,242Z2@183968|Thermococci	183968|Thermococci	L	DNA polymerase	pol	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing,LAGLIDADG_3
CH1_k127_10419767_0	1229909.NSED_00120	9.8e-79	266.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CH1_k127_10419767_2	986075.CathTA2_1352	6.229e-26	113.0	COG1986@1|root,COG1986@2|Bacteria	2|Bacteria	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	yjjX	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	iECO111_1330.ECO111_5255	NTPase_I-T
CH1_k127_10419767_3	386456.JQKN01000002_gene2773	4.596e-13	80.0	COG0040@1|root,arCOG02208@2157|Archaea,2Y32G@28890|Euryarchaeota,23PBA@183925|Methanobacteria	183925|Methanobacteria	E	PFAM ATP phosphoribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	HisG
CH1_k127_10419767_1	1349785.BAUG01000035_gene1932	3.06e-31	130.0	COG0527@1|root,COG0527@2|Bacteria,4NJDY@976|Bacteroidetes,1HYZX@117743|Flavobacteriia	976|Bacteroidetes	E	aspartate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_10425462_0	1449126.JQKL01000054_gene3129	5.003e-191	625.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,268CA@186813|unclassified Clostridiales	186801|Clostridia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
CH1_k127_10425462_1	589924.Ferp_0098	3.919e-55	214.0	COG1193@1|root,arCOG02895@2157|Archaea,2XU2F@28890|Euryarchaeota,2460G@183980|Archaeoglobi	183980|Archaeoglobi	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V
CH1_k127_10425462_3	662479.C440_14549	5.154e-18	92.0	COG0500@1|root,arCOG04583@2157|Archaea,2XTVC@28890|Euryarchaeota,23ST5@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CH1_k127_10425462_2	1137799.GZ78_23840	6.131e-25	107.0	COG1051@1|root,COG1051@2|Bacteria,1RF2T@1224|Proteobacteria,1S44A@1236|Gammaproteobacteria,1XQFQ@135619|Oceanospirillales	135619|Oceanospirillales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CH1_k127_10510281_4	1254432.SCE1572_50135	2.61e-05	56.0	29XGE@1|root,30J6W@2|Bacteria,1R0E6@1224|Proteobacteria,43CWN@68525|delta/epsilon subdivisions,2WUSC@28221|Deltaproteobacteria,2Z1N5@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_10510281_0	1047013.AQSP01000064_gene1487	1.707e-167	538.0	COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the RtcB family	rtcB	GO:0003674,GO:0003824,GO:0003909,GO:0005488,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0030145,GO:0033554,GO:0034641,GO:0042245,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:0140098,GO:1901360	6.5.1.3	ko:K14415,ko:K18148	ko01501,map01501	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	RtcB
CH1_k127_10510281_1	1229909.NSED_08345	9.479e-25	108.0	arCOG04405@1|root,arCOG04405@2157|Archaea	2157|Archaea	S	ASCH domain	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
CH1_k127_10510281_3	391623.TERMP_00600	5.296e-17	87.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,242RW@183968|Thermococci	183968|Thermococci	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	Archease
CH1_k127_10510281_2	679926.Mpet_1821	2.119e-23	110.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2NAP1@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
CH1_k127_10533275_0	342949.PNA2_0520	7.866e-15	78.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
CH1_k127_10533275_2	186497.PF2009	1.147e-05	49.0	COG1996@1|root,arCOG04341@2157|Archaea,2Y5NT@28890|Euryarchaeota,244P7@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
CH1_k127_10533275_1	589924.Ferp_2266	1.44e-07	57.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,246EF@183980|Archaeoglobi	183980|Archaeoglobi	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
CH1_k127_10675504_1	647113.Metok_1325	6.098e-17	83.0	COG0477@1|root,arCOG00130@2157|Archaea,2XU3E@28890|Euryarchaeota,23QKI@183939|Methanococci	183939|Methanococci	G	PFAM Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CH1_k127_10675504_0	589924.Ferp_0995	1.158e-140	458.0	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,245VM@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
CH1_k127_10712463_2	439481.Aboo_0131	7.761e-08	64.0	COG1708@1|root,COG1895@1|root,arCOG01204@2157|Archaea,arCOG02123@2157|Archaea,2Y5D9@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM DNA polymerase, beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
CH1_k127_10712463_1	604354.TSIB_0516	2.155e-17	84.0	COG2451@1|root,arCOG04304@2157|Archaea,2Y0KT@28890|Euryarchaeota,244KT@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
CH1_k127_10712463_0	666510.ASAC_1233	1.447e-17	89.0	COG0197@1|root,arCOG04113@2157|Archaea,2XQ8E@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
CH1_k127_1077805_0	269797.Mbar_A0890	6.351e-25	112.0	COG0207@1|root,arCOG03214@2157|Archaea,2XYEP@28890|Euryarchaeota,2NBGJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
CH1_k127_10903424_0	1343739.PAP_02030	1.91e-45	172.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,242MQ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
CH1_k127_10937678_0	647113.Metok_1474	7.756e-147	488.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,23QA8@183939|Methanococci	183939|Methanococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,Topoisom_bac,Toprim,zf-C4_Topoisom
CH1_k127_10937678_2	246197.MXAN_1823	2.699e-19	93.0	2CGYE@1|root,3355Z@2|Bacteria,1NJNH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_10937678_1	386456.JQKN01000001_gene1784	3.31e-32	132.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,23NZU@183925|Methanobacteria	183925|Methanobacteria	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
CH1_k127_10966822_0	523845.AQXV01000054_gene1670	1.088e-28	119.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,23R0K@183939|Methanococci	183939|Methanococci	J	Involved in the binding of tRNA to the ribosomes	rps10	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
CH1_k127_10966822_1	1280.SAXN108_1341	2.525e-16	88.0	COG1525@1|root,COG1525@2|Bacteria,1VASF@1239|Firmicutes,4HM0N@91061|Bacilli,4GZ2J@90964|Staphylococcaceae	91061|Bacilli	L	thermonuclease	nucI	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
CH1_k127_11074773_0	457398.HMPREF0326_01288	1.499e-18	89.0	2DBJQ@1|root,32TXM@2|Bacteria,1NYZU@1224|Proteobacteria,430QH@68525|delta/epsilon subdivisions,2WW08@28221|Deltaproteobacteria,2MCPA@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_excise
CH1_k127_11249805_0	439481.Aboo_0942	1.945e-88	309.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,3F2FJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2,Intein_splicing,LAGLIDADG_3
CH1_k127_11285956_0	877455.Metbo_0166	4.296e-97	324.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,23PFS@183925|Methanobacteria	183925|Methanobacteria	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_2,HHH_5,Rad51
CH1_k127_11285956_2	589924.Ferp_1404	1.801e-05	51.0	COG1594@1|root,arCOG00579@2157|Archaea,2XY3E@28890|Euryarchaeota,2473M@183980|Archaeoglobi	183980|Archaeoglobi	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
CH1_k127_11285956_1	161156.JQKW01000010_gene361	1.431e-33	135.0	COG1379@1|root,COG1379@2|Bacteria,2GH9W@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_11692765_0	290315.Clim_1350	1.17e-13	79.0	COG0514@1|root,COG1061@1|root,COG1403@1|root,COG0514@2|Bacteria,COG1061@2|Bacteria,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	3.6.4.12	ko:K03654,ko:K03657,ko:K06877,ko:K07451	ko03018,ko03420,ko03430,map03018,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03400	-	-	-	DEAD,DUF3427,HNH,Helicase_C,PLDc_2,RQC,ResIII
CH1_k127_11916745_0	647113.Metok_0524	2.034e-50	183.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23QF3@183939|Methanococci	183939|Methanococci	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
CH1_k127_12016796_1	186497.PF1553	1.123e-09	61.0	COG0144@1|root,arCOG00973@2157|Archaea,2XUFZ@28890|Euryarchaeota,243DP@183968|Thermococci	183968|Thermococci	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016427,GO:0016428,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	-	ko:K22446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
CH1_k127_12016796_3	1122216.AUHW01000023_gene825	6.679e-09	63.0	COG0454@1|root,COG0454@2|Bacteria,1UHUT@1239|Firmicutes	1239|Firmicutes	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
CH1_k127_12016796_2	1042877.GQS_01310	1.824e-09	65.0	COG3270@1|root,arCOG02285@2157|Archaea,2XZD7@28890|Euryarchaeota,24491@183968|Thermococci	183968|Thermococci	J	RNA-binding PUA-like domain of methyltransferase RsmF	-	-	-	-	-	-	-	-	-	-	-	-	Methyltranf_PUA
CH1_k127_12016796_0	765177.Desmu_1233	3.32e-48	185.0	COG0024@1|root,arCOG01001@2157|Archaea,2XPVJ@28889|Crenarchaeota	28889|Crenarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CH1_k127_12088392_1	579137.Metvu_1652	6.093e-30	126.0	COG0064@1|root,arCOG01718@2157|Archaea,2XSV3@28890|Euryarchaeota,23QJM@183939|Methanococci	183939|Methanococci	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
CH1_k127_12088392_2	945712.CULC22_02308	2.119e-24	116.0	COG0814@1|root,COG0814@2|Bacteria,2H8GD@201174|Actinobacteria,22M11@1653|Corynebacteriaceae	201174|Actinobacteria	E	Amino acid permeases	-	-	-	-	-	-	-	-	-	-	-	-	Trp_Tyr_perm
CH1_k127_12088392_0	8496.XP_006272972.1	9.576e-93	313.0	COG0008@1|root,COG0442@1|root,KOG1147@2759|Eukaryota,KOG4163@2759|Eukaryota,38B44@33154|Opisthokonta,3BBW2@33208|Metazoa,3CX8R@33213|Bilateria,4835V@7711|Chordata,48ZMJ@7742|Vertebrata	33208|Metazoa	J	Bifunctional glutamate proline--tRNA ligase	EPRS	GO:0002376,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004818,GO:0004827,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006424,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009719,GO:0009725,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010876,GO:0015711,GO:0015718,GO:0015849,GO:0015908,GO:0015909,GO:0016020,GO:0016043,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0017148,GO:0019222,GO:0019538,GO:0019752,GO:0019899,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032868,GO:0032869,GO:0032870,GO:0032991,GO:0033036,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034641,GO:0034645,GO:0034660,GO:0035613,GO:0042221,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044539,GO:0045087,GO:0046483,GO:0046872,GO:0046914,GO:0046942,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051716,GO:0060255,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071345,GO:0071346,GO:0071375,GO:0071417,GO:0071495,GO:0071702,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097452,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1990904,GO:2000112,GO:2000113	6.1.1.15,6.1.1.17	ko:K01885,ko:K14163	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03661,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	GST_C,GST_C_3,HGTP_anticodon,ProRS-C_1,WHEP-TRS,tRNA-synt_1c,tRNA-synt_1c_C,tRNA-synt_2b
CH1_k127_12138860_0	373903.Hore_06890	4.732e-88	303.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,3WANK@53433|Halanaerobiales	186801|Clostridia	E	Thermophilic metalloprotease (M29)	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
CH1_k127_12138860_2	195522.BD01_0819	1.025e-06	56.0	arCOG05517@1|root,arCOG05517@2157|Archaea,2Y3ZJ@28890|Euryarchaeota,24450@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_12138860_1	351160.RCIX690	8.271e-07	54.0	COG1873@1|root,arCOG02155@2157|Archaea,2XYZ2@28890|Euryarchaeota,2NA15@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
CH1_k127_12307194_2	324057.Pjdr2_5246	3.161e-28	119.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,4HH8C@91061|Bacilli,272M0@186822|Paenibacillaceae	91061|Bacilli	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
CH1_k127_12307194_1	6326.BUX.s00351.108	3.008e-37	147.0	COG0127@1|root,KOG3222@2759|Eukaryota,38DZ3@33154|Opisthokonta,3BE5N@33208|Metazoa,3CSAU@33213|Bilateria,40DDE@6231|Nematoda,1KVR4@119089|Chromadorea	33208|Metazoa	F	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions	ITPA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006193,GO:0006195,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009150,GO:0009154,GO:0009166,GO:0009199,GO:0009203,GO:0009205,GO:0009207,GO:0009259,GO:0009261,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046041,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0051276,GO:0055086,GO:0071704,GO:0071840,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	-	ko:K01519	ko00230,ko00983,ko01100,map00230,map00983,map01100	-	R00426,R00720,R01855,R02100,R02720,R03531,R08243	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
CH1_k127_12307194_3	304371.MCP_1055	2.034e-06	58.0	COG1378@1|root,arCOG02037@2157|Archaea,2XYIM@28890|Euryarchaeota,2N9T1@224756|Methanomicrobia	224756|Methanomicrobia	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
CH1_k127_12307194_0	795359.TOPB45_0317	3.811e-53	195.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CH1_k127_12314329_1	246194.CHY_1798	2.43e-08	59.0	COG0778@1|root,COG0778@2|Bacteria,1V8BZ@1239|Firmicutes,25B4H@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CH1_k127_12314329_2	330779.Saci_2136	5.129e-08	64.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_IclR,TrmB
CH1_k127_12314329_3	1430331.EP10_12660	1.591e-06	59.0	COG1522@1|root,COG1522@2|Bacteria,1V1DR@1239|Firmicutes,4HFRT@91061|Bacilli,1WFUB@129337|Geobacillus	91061|Bacilli	K	AsnC-type helix-turn-helix domain	ywrC	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CH1_k127_1235233_0	523850.TON_0507	5.651e-97	329.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,243E3@183968|Thermococci	183968|Thermococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
CH1_k127_1235233_1	1041930.Mtc_1018	1.053e-49	185.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
CH1_k127_1236058_0	647113.Metok_0259	2.781e-113	378.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
CH1_k127_1236058_1	929556.Solca_0050	2.619e-36	153.0	COG1470@1|root,COG3209@1|root,COG4932@1|root,COG1470@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,4PKBQ@976|Bacteroidetes,1J0N1@117747|Sphingobacteriia	976|Bacteroidetes	M	conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,SprB
CH1_k127_12362632_0	877455.Metbo_0322	4.018e-196	630.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
CH1_k127_12362632_2	243232.MJ_1237	2.049e-34	141.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23QK3@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
CH1_k127_12362632_1	386456.JQKN01000008_gene1391	4.356e-41	164.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
CH1_k127_12385810_1	1205680.CAKO01000040_gene808	1.289e-33	136.0	2AY4N@1|root,31Q6J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_12385810_0	1449050.JNLE01000003_gene265	3.689e-42	160.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,36DSA@31979|Clostridiaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
CH1_k127_12430785_0	70601.3258431	8.951e-102	341.0	COG0533@1|root,arCOG01183@2157|Archaea,2Y86G@28890|Euryarchaeota,2435F@183968|Thermococci	183968|Thermococci	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity	kae1	GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CH1_k127_12430785_1	368408.Tpen_0032	1.191e-23	106.0	COG4900@1|root,arCOG04217@2157|Archaea,2XQUZ@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_12430785_3	118163.Ple7327_3360	2.027e-09	61.0	COG1872@1|root,COG1872@2|Bacteria,1G935@1117|Cyanobacteria,3VKP9@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Uncharacterised ACR, YggU family COG1872	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
CH1_k127_12430785_2	1227500.C494_02850	9.195e-20	90.0	COG0012@1|root,arCOG00357@2157|Archaea,2XV2N@28890|Euryarchaeota,23TCR@183963|Halobacteria	183963|Halobacteria	J	translation factor	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
CH1_k127_12522130_0	572546.Arcpr_1565	2.037e-191	627.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,246MU@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
CH1_k127_12539965_1	330779.Saci_1306	2.72e-20	98.0	COG0528@1|root,arCOG00858@2157|Archaea,2XQKQ@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CH1_k127_12539965_2	573063.Metin_0219	1.217e-05	53.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,23QMK@183939|Methanococci	183939|Methanococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
CH1_k127_12539965_0	456320.Mvol_1085	2.844e-92	322.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,23Q8D@183939|Methanococci	183939|Methanococci	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
CH1_k127_12547336_0	1444711.CCJF01000005_gene1106	5.505e-06	56.0	2EWWH@1|root,33Q7W@2|Bacteria,2JGTK@204428|Chlamydiae	204428|Chlamydiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_12551901_0	186497.PF1415	7.629e-34	140.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
CH1_k127_12583403_0	795797.C497_07524	3.81e-23	110.0	COG0628@1|root,arCOG02642@2157|Archaea,2XU4M@28890|Euryarchaeota,23TXJ@183963|Halobacteria	183963|Halobacteria	S	Permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CH1_k127_12583403_1	304371.MCP_1319	2.791e-17	82.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
CH1_k127_12583403_2	1449126.JQKL01000001_gene1390	1.308e-14	78.0	COG4508@1|root,COG4508@2|Bacteria,1VDR2@1239|Firmicutes,24NTJ@186801|Clostridia	186801|Clostridia	S	dUTPase	-	-	-	-	-	-	-	-	-	-	-	-	dUTPase_2
CH1_k127_1265785_0	402880.MmarC5_0593	6.219e-61	225.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,23QCI@183939|Methanococci	183939|Methanococci	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
CH1_k127_12821046_2	344747.PM8797T_19602	7.214e-38	150.0	COG0563@1|root,COG0563@2|Bacteria,2IZRF@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK
CH1_k127_12821046_0	386456.JQKN01000012_gene1064	5.017e-69	241.0	COG1418@1|root,arCOG01860@2157|Archaea,2XT54@28890|Euryarchaeota	28890|Euryarchaeota	S	HD superfamily hydrolase	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
CH1_k127_12821046_1	515635.Dtur_1496	6.302e-58	213.0	COG0301@1|root,COG1293@1|root,COG0301@2|Bacteria,COG1293@2|Bacteria	2|Bacteria	K	actin binding	FbpA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	DUF814,FbpA,ThiI
CH1_k127_12821399_1	1386089.N865_04250	2e-13	76.0	COG0477@1|root,COG0477@2|Bacteria,2HX73@201174|Actinobacteria,4FFCS@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CH1_k127_12821399_0	398512.JQKC01000004_gene5273	4.819e-38	153.0	COG3694@1|root,COG3694@2|Bacteria,1V3DF@1239|Firmicutes,25DJX@186801|Clostridia,3WN7P@541000|Ruminococcaceae	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
CH1_k127_12821399_2	720554.Clocl_1372	1.015e-09	62.0	COG4587@1|root,COG4587@2|Bacteria,1V4UC@1239|Firmicutes,24FVY@186801|Clostridia	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
CH1_k127_12937883_4	331678.Cphamn1_1744	6.491e-08	61.0	2C4PE@1|root,347IM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_12937883_0	192875.XP_004363785.1	2.363e-45	176.0	KOG3128@1|root,KOG3128@2759|Eukaryota,39AX7@33154|Opisthokonta	33154|Opisthokonta	S	Belongs to the pyrimidine 5'-nucleotidase family	NT5C3B	GO:0000215,GO:0000287,GO:0000288,GO:0000291,GO:0000956,GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006401,GO:0006402,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009057,GO:0009058,GO:0009116,GO:0009119,GO:0009123,GO:0009125,GO:0009158,GO:0009161,GO:0009164,GO:0009605,GO:0009607,GO:0009615,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0012505,GO:0016070,GO:0016071,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0019222,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043928,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046128,GO:0046130,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0048519,GO:0050789,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:0090304,GO:0098542,GO:0140098,GO:0140101,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	UMPH-1
CH1_k127_12937883_1	363253.LI0430	7.136e-30	123.0	COG0537@1|root,COG0537@2|Bacteria,1PDTP@1224|Proteobacteria,42UAD@68525|delta/epsilon subdivisions,2WQRN@28221|Deltaproteobacteria,2MBWX@213115|Desulfovibrionales	28221|Deltaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
CH1_k127_12937883_5	456442.Mboo_1869	1.494e-07	57.0	arCOG04003@1|root,arCOG04003@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4405
CH1_k127_12937883_3	1297742.A176_06726	4.353e-10	73.0	COG4935@1|root,COG5184@1|root,COG4935@2|Bacteria,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,RCC1
CH1_k127_12937883_2	261292.Nit79A3_2343	5.977e-14	85.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	Laminin_G_3,PKD,TIG,TPP_enzyme_M,fn3
CH1_k127_12981726_0	1227497.C491_20632	5.356e-125	420.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,23TTN@183963|Halobacteria	183963|Halobacteria	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
CH1_k127_12981726_1	1236689.MMALV_07170	5.894e-47	175.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,3F2KX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
CH1_k127_13076901_0	523850.TON_1414	2.018e-108	360.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,2433R@183968|Thermococci	183968|Thermococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rep_fac_C,RuvB_N
CH1_k127_13076901_1	1379698.RBG1_1C00001G1780	8.124e-15	76.0	COG0826@1|root,COG0826@2|Bacteria,2NS1M@2323|unclassified Bacteria	2|Bacteria	O	peptidase U32	yegQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
CH1_k127_13157260_0	1006006.Mcup_0431	2.197e-05	50.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
CH1_k127_13199266_0	1449050.JNLE01000003_gene559	1.115e-181	583.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,24CAI@186801|Clostridia,36GPX@31979|Clostridiaceae	186801|Clostridia	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
CH1_k127_13245568_2	1122605.KB893645_gene957	2.955e-12	81.0	COG2730@1|root,COG2730@2|Bacteria,4NF3J@976|Bacteroidetes,1IRPS@117747|Sphingobacteriia	976|Bacteroidetes	G	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
CH1_k127_13245568_0	521011.Mpal_1878	2.803e-82	279.0	COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
CH1_k127_13245568_1	247490.KSU1_C0048	9.911e-42	163.0	COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CH1_k127_13259001_0	869209.Tresu_0461	4.256e-184	593.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CH1_k127_13259001_2	342949.PNA2_1228	2.284e-15	84.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2438P@183968|Thermococci	183968|Thermococci	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
CH1_k127_13259001_1	644281.MFS40622_1590	2.417e-16	87.0	COG0705@1|root,arCOG01770@2157|Archaea,2Y895@28890|Euryarchaeota,23RKY@183939|Methanococci	183939|Methanococci	E	PFAM Rhomboid family protein	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid
CH1_k127_13264033_0	498761.HM1_0789	1.911e-56	211.0	COG0553@1|root,COG0553@2|Bacteria,1TQ5E@1239|Firmicutes,25C98@186801|Clostridia	186801|Clostridia	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
CH1_k127_13269518_2	426368.MmarC7_1187	3.557e-15	79.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,23Q99@183939|Methanococci	183939|Methanococci	J	PFAM Diphthamide synthesis DPH2 protein	-	GO:0006417,GO:0006448,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:2000112,GO:2000765	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
CH1_k127_13269518_0	411463.EUBVEN_02756	6.389e-38	152.0	COG3541@1|root,COG3541@2|Bacteria,1TT57@1239|Firmicutes,24EJG@186801|Clostridia	186801|Clostridia	S	Predicted nucleotidyltransferase	-	-	-	ko:K07074	-	-	-	-	ko00000	-	-	-	Nuc-transf
CH1_k127_13269518_1	1047013.AQSP01000054_gene254	7.302e-28	116.0	COG0756@1|root,COG0756@2|Bacteria,2NPXR@2323|unclassified Bacteria	2|Bacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23,4.1.1.36,6.3.2.5	ko:K01520,ko:K13038	ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100	M00053,M00120	R02100,R03269,R04231,R11896	RC00002,RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
CH1_k127_13477825_1	386456.JQKN01000018_gene597	1.396e-74	270.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,23NMR@183925|Methanobacteria	183925|Methanobacteria	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B
CH1_k127_13477825_0	272844.PAB2265	2.92e-112	376.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
CH1_k127_1363851_2	641526.ADIWIN_2506	4.605e-06	53.0	COG3647@1|root,COG3647@2|Bacteria,4NMNV@976|Bacteroidetes,1I1B4@117743|Flavobacteriia	976|Bacteroidetes	S	membrane	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
CH1_k127_1363851_0	69014.TK2215	2.126e-31	129.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,243N3@183968|Thermococci	183968|Thermococci	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
CH1_k127_1363851_1	1121101.HMPREF1532_01915	9.116e-21	96.0	COG0495@1|root,COG0495@2|Bacteria,4NE5K@976|Bacteroidetes,2FM7V@200643|Bacteroidia,4AMDE@815|Bacteroidaceae	976|Bacteroidetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,DUF559,tRNA-synt_1,tRNA-synt_1_2
CH1_k127_13782440_2	313606.M23134_08193	0.0001056	49.0	COG1372@1|root,COG1372@2|Bacteria	2|Bacteria	L	intein-mediated protein splicing	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS,RHS_repeat,SpvB
CH1_k127_13782440_0	1041930.Mtc_1686	5.067e-39	154.0	COG2253@1|root,arCOG03839@2157|Archaea,2XWPU@28890|Euryarchaeota	28890|Euryarchaeota	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	ko:K09144	-	-	-	-	ko00000	-	-	-	AbiEii
CH1_k127_13782440_1	1041930.Mtc_1685	7.538e-23	107.0	COG5340@1|root,arCOG04793@2157|Archaea,2XVVB@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1,AbiEi_4
CH1_k127_13791020_0	314256.OG2516_01209	9.455e-06	53.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,2PDKD@252301|Oceanicola	28211|Alphaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
CH1_k127_13916860_1	1094980.Mpsy_1854	4.103e-31	126.0	COG3177@1|root,arCOG03112@2157|Archaea,2Y8I1@28890|Euryarchaeota,2NBD5@224756|Methanomicrobia	224756|Methanomicrobia	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
CH1_k127_13916860_2	596152.DesU5LDRAFT_0232	0.0003575	48.0	COG0727@1|root,COG0727@2|Bacteria,1QEC4@1224|Proteobacteria,435YJ@68525|delta/epsilon subdivisions,2X0FF@28221|Deltaproteobacteria,2MC52@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_13916860_0	456442.Mboo_0460	3.385e-53	194.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota	28890|Euryarchaeota	O	Peptidyl-prolyl cis-trans isomerase	ppiA	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
CH1_k127_13949362_2	572546.Arcpr_0239	2.582e-38	147.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,24658@183980|Archaeoglobi	183980|Archaeoglobi	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
CH1_k127_13949362_5	224325.AF_2066	3.379e-11	71.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,246DC@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the ribosomal protein L31e family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
CH1_k127_13949362_4	83406.HDN1F_26100	1.567e-15	81.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1J4R0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0642 Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Reg_prop,Response_reg,Y_Y_Y
CH1_k127_13949362_1	351160.RCIX2575	1.484e-39	159.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
CH1_k127_13949362_3	1123371.ATXH01000003_gene1973	1.245e-17	85.0	COG1254@1|root,COG1254@2|Bacteria,2GHZK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
CH1_k127_13949362_0	941824.TCEL_02178	1.516e-132	439.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,36DX4@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
CH1_k127_14018185_1	572546.Arcpr_1230	9.913e-12	75.0	COG0704@1|root,arCOG00318@2157|Archaea,2XWZZ@28890|Euryarchaeota,2464P@183980|Archaeoglobi	183980|Archaeoglobi	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
CH1_k127_14018185_0	485916.Dtox_4086	5.331e-26	120.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,26144@186807|Peptococcaceae	186801|Clostridia	S	PFAM PHP domain	trpH	-	3.1.3.97,3.1.4.57	ko:K07053,ko:K20859	ko00440,map00440	-	R00188,R10972,R10973,R11188	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
CH1_k127_14069797_0	221027.JO40_07945	1.491e-87	298.0	COG0018@1|root,COG0018@2|Bacteria,2J5EP@203691|Spirochaetes	203691|Spirochaetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CH1_k127_14069797_1	3075.A0A087SKN8	1.934e-12	75.0	COG1443@1|root,KOG0142@2759|Eukaryota	2759|Eukaryota	I	isopentenyl-diphosphate delta-isomerase activity	-	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
CH1_k127_14087783_0	1089553.Tph_c23510	9.477e-44	169.0	COG1533@1|root,COG1533@2|Bacteria,1TRIS@1239|Firmicutes,25CEW@186801|Clostridia,42GDQ@68295|Thermoanaerobacterales	186801|Clostridia	L	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CH1_k127_14087783_4	985255.APHJ01000023_gene2564	0.0004643	49.0	COG4339@1|root,COG4339@2|Bacteria,4PKIS@976|Bacteroidetes,1IJAC@117743|Flavobacteriia,2P66K@244698|Gillisia	976|Bacteroidetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
CH1_k127_14087783_1	195522.BD01_0631	3.637e-33	137.0	COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,243KR@183968|Thermococci	183968|Thermococci	S	Catalyzes the dephosphorylation of D,L-glyceraldehyde 3- phosphate in vitro	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CH1_k127_14087783_2	1408473.JHXO01000010_gene3629	1.221e-24	111.0	COG0546@1|root,COG0546@2|Bacteria,4NX0N@976|Bacteroidetes	976|Bacteroidetes	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CH1_k127_14087783_3	1401065.HMPREF2130_11975	1.738e-10	67.0	COG1278@1|root,COG1404@1|root,COG1278@2|Bacteria,COG1404@2|Bacteria,1N0Q5@1224|Proteobacteria	1224|Proteobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD
CH1_k127_14104981_1	1122947.FR7_3750	3.171e-11	72.0	COG0546@1|root,COG0546@2|Bacteria,1V34Q@1239|Firmicutes	1239|Firmicutes	S	hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CH1_k127_14104981_2	292459.STH1154	4.662e-09	65.0	COG1011@1|root,COG1011@2|Bacteria,1VK8H@1239|Firmicutes	1239|Firmicutes	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	-
CH1_k127_14104981_0	572546.Arcpr_0923	5.56e-22	100.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,245WN@183980|Archaeoglobi	183980|Archaeoglobi	G	Xylose isomerase domain protein TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
CH1_k127_1411061_0	269797.Mbar_A3709	1.794e-40	168.0	arCOG01814@1|root,arCOG01814@2157|Archaea,2XT74@28890|Euryarchaeota,2N90N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_1441634_0	1114856.C496_21739	1.558e-16	85.0	COG1591@1|root,arCOG00919@2157|Archaea,2XTHF@28890|Euryarchaeota,23TR3@183963|Halobacteria	183963|Halobacteria	L	A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products	hjc	-	3.1.22.4	ko:K03552	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Hjc
CH1_k127_1471776_0	591019.Shell_0072	9.788e-42	160.0	COG0258@1|root,arCOG04050@2157|Archaea,2XPRH@28889|Crenarchaeota	28889|Crenarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
CH1_k127_1472643_0	1382306.JNIM01000001_gene527	1.819e-71	248.0	COG1051@1|root,COG1051@2|Bacteria,2G6QH@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
CH1_k127_1472643_1	868864.Dester_1109	1.342e-48	187.0	COG0057@1|root,COG0057@2|Bacteria,2G3TK@200783|Aquificae	200783|Aquificae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CH1_k127_1472643_2	1034943.BN1094_01907	5.947e-31	131.0	2DE7X@1|root,2ZKX3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_1472643_3	638303.Thal_0519	5.617e-08	56.0	COG1057@1|root,COG1057@2|Bacteria,2G440@200783|Aquificae	200783|Aquificae	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CH1_k127_1536623_2	930945.SiRe_0144	0.0006703	51.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQS8@28889|Crenarchaeota	28889|Crenarchaeota	K	ASNC family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CH1_k127_1536623_0	1157637.KB892099_gene2222	1.836e-06	60.0	COG1522@1|root,COG1522@2|Bacteria,2GN6I@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
CH1_k127_1536623_1	387631.Asulf_00905	5.904e-06	56.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,245R5@183980|Archaeoglobi	183980|Archaeoglobi	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
CH1_k127_1586607_13	523850.TON_1971	0.0004763	51.0	COG1300@1|root,arCOG01994@2157|Archaea,2XTS9@28890|Euryarchaeota,245H0@183968|Thermococci	183968|Thermococci	S	Stage II sporulation protein M	-	-	-	ko:K06384	-	-	-	-	ko00000	-	-	-	SpoIIM
CH1_k127_1586607_2	633148.Tagg_0677	1.099e-32	138.0	COG1184@1|root,arCOG01124@2157|Archaea,2XPZN@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
CH1_k127_1586607_0	339860.Msp_0885	1.118e-102	349.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,23NV1@183925|Methanobacteria	183925|Methanobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
CH1_k127_1586607_12	444157.Tneu_1303	2.491e-06	55.0	COG0200@1|root,arCOG00779@2157|Archaea,2XQH0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
CH1_k127_1586607_6	224325.AF_1904	1.081e-24	108.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,2464S@183980|Archaeoglobi	183980|Archaeoglobi	J	Ribosomal protein L30	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
CH1_k127_1586607_1	768679.TTX_1410	2.688e-53	196.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
CH1_k127_1586607_5	572478.Vdis_2304	2.512e-25	111.0	COG0256@1|root,arCOG04088@2157|Archaea,2XPNF@28889|Crenarchaeota	28889|Crenarchaeota	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
CH1_k127_1586607_9	529709.PYCH_01560	5.93e-11	68.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,243Y0@183968|Thermococci	183968|Thermococci	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
CH1_k127_1586607_10	644281.MFS40622_1743	7.52e-11	68.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,23QZM@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
CH1_k127_1586607_4	1220534.B655_1496	8.34e-26	113.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,23PAC@183925|Methanobacteria	183925|Methanobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
CH1_k127_1586607_7	554065.XP_005849532.1	1.941e-24	106.0	COG0096@1|root,KOG1754@2759|Eukaryota,37TR4@33090|Viridiplantae,34KFX@3041|Chlorophyta	3041|Chlorophyta	J	ribosomal protein S15a	RPS15a	-	-	ko:K02957	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
CH1_k127_1586607_8	1163730.FFONT_0506	4.487e-11	66.0	COG0199@1|root,arCOG00782@2157|Archaea,2XR7G@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
CH1_k127_1586607_3	671065.MetMK1DRAFT_00021720	2.02e-27	118.0	COG0094@1|root,arCOG04092@2157|Archaea,2XQDJ@28889|Crenarchaeota	28889|Crenarchaeota	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
CH1_k127_1586607_11	339860.Msp_0896	1.454e-07	56.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,23NT9@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
CH1_k127_1650733_1	426368.MmarC7_1795	8.122e-65	233.0	COG0475@1|root,arCOG01955@2157|Archaea,2XWIX@28890|Euryarchaeota,23RH1@183939|Methanococci	183939|Methanococci	P	PFAM TrkA-N domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
CH1_k127_1650733_0	647113.Metok_1244	2.683e-73	256.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,23QPY@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	-	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006196,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009125,GO:0009126,GO:0009128,GO:0009150,GO:0009154,GO:0009158,GO:0009161,GO:0009166,GO:0009167,GO:0009169,GO:0009259,GO:0009261,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
CH1_k127_1664075_0	579137.Metvu_1266	1.76e-110	372.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,23QJI@183939|Methanococci	183939|Methanococci	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CH1_k127_1664075_1	1499967.BAYZ01000160_gene414	6.239e-11	63.0	COG1524@1|root,COG1524@2|Bacteria,2NQ0M@2323|unclassified Bacteria	2|Bacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CH1_k127_170373_0	1121346.KB899834_gene910	4.189e-97	328.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,4HEB4@91061|Bacilli,26Q9J@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH1_k127_170373_1	1408416.JNJT01000011_gene588	1.626e-15	83.0	COG4587@1|root,COG4587@2|Bacteria	2|Bacteria	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
CH1_k127_1757233_1	178306.PAE3337	3.633e-20	98.0	COG0231@1|root,arCOG04277@2157|Archaea,2XQCW@28889|Crenarchaeota	28889|Crenarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
CH1_k127_1757233_0	224719.Abm4_1506	8.296e-28	120.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,23NZB@183925|Methanobacteria	183925|Methanobacteria	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
CH1_k127_1842877_5	1156937.MFUM_210018	1.94e-05	56.0	COG0040@1|root,COG0040@2|Bacteria,46SHK@74201|Verrucomicrobia,37G6J@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
CH1_k127_1842877_0	1150600.ADIARSV_0974	1.223e-53	198.0	COG1235@1|root,COG1235@2|Bacteria,4NDVI@976|Bacteroidetes,1IR6D@117747|Sphingobacteriia	976|Bacteroidetes	S	COGs COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I	vicX	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
CH1_k127_1842877_4	1304885.AUEY01000017_gene3764	2.815e-06	57.0	COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,43AE6@68525|delta/epsilon subdivisions,2X6A8@28221|Deltaproteobacteria,2MPXN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CH1_k127_1842877_2	456442.Mboo_0033	2.306e-10	66.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
CH1_k127_1842877_1	246194.CHY_2227	1.052e-30	132.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,42GGH@68295|Thermoanaerobacterales	186801|Clostridia	S	SMART phosphoesterase PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
CH1_k127_1842877_3	930945.SiRe_2585	9.356e-08	60.0	COG0704@1|root,arCOG00320@2157|Archaea,2XSEB@28889|Crenarchaeota	28889|Crenarchaeota	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
CH1_k127_1982202_2	1123508.JH636440_gene2004	2.259e-10	67.0	2DPWK@1|root,32UMZ@2|Bacteria,2J322@203682|Planctomycetes	203682|Planctomycetes	S	Nucleoside 2-deoxyribosyltransferase like	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyri_tr2
CH1_k127_1982202_0	386456.JQKN01000008_gene1390	9.36e-45	178.0	COG0420@1|root,arCOG00397@2157|Archaea,2XWH1@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
CH1_k127_1982202_1	5850.PKH_140160	2.547e-20	98.0	COG2890@1|root,KOG3191@2759|Eukaryota,3YB0I@5794|Apicomplexa,3KB94@422676|Aconoidasida,3YYDM@5819|Haemosporida	422676|Aconoidasida	H	Methyltransferase small domain	-	-	2.1.1.297	ko:K19589	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	MTS
CH1_k127_1988115_6	1380384.JADN01000008_gene1031	7.154e-06	56.0	COG1522@1|root,COG1522@2|Bacteria,4NNH2@976|Bacteroidetes,1I2AJ@117743|Flavobacteriia	976|Bacteroidetes	K	transcriptional regulator	lrp	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CH1_k127_1988115_3	1123500.ATUU01000001_gene82	9.181e-21	105.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,4HH47@91061|Bacilli,4AWIT@81850|Leuconostocaceae	91061|Bacilli	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CH1_k127_1988115_4	1506583.JQJY01000001_gene798	8.913e-09	67.0	COG0237@1|root,COG0237@2|Bacteria,4NQKS@976|Bacteroidetes,1I1XH@117743|Flavobacteriia,2NUAP@237|Flavobacterium	976|Bacteroidetes	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
CH1_k127_1988115_1	743720.Psefu_1417	4.226e-36	146.0	COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,1S59I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_1988115_2	1501230.ET33_25970	1.558e-30	130.0	COG1234@1|root,COG1234@2|Bacteria,1UYM3@1239|Firmicutes,4HEWE@91061|Bacilli,26U57@186822|Paenibacillaceae	91061|Bacilli	S	beta-lactamase	rnaZ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
CH1_k127_1988115_5	1163730.FFONT_1188	4.447e-07	61.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CH1_k127_1988115_0	864702.OsccyDRAFT_0931	2.21e-49	188.0	COG1235@1|root,COG1235@2|Bacteria,1G166@1117|Cyanobacteria,1H884@1150|Oscillatoriales	1117|Cyanobacteria	S	of the beta-lactamase superfamily I	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CH1_k127_2032006_0	309799.DICTH_1708	2.752e-73	262.0	COG3635@1|root,COG3635@2|Bacteria	2|Bacteria	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
CH1_k127_2032006_4	70601.3257074	0.0004406	49.0	COG1711@1|root,arCOG00551@2157|Archaea,2XXPT@28890|Euryarchaeota,2446R@183968|Thermococci	183968|Thermococci	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
CH1_k127_2032006_2	1120985.AUMI01000011_gene541	2.145e-25	113.0	COG3271@1|root,COG3271@2|Bacteria,1VAKE@1239|Firmicutes,4H81P@909932|Negativicutes	909932|Negativicutes	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_2032006_3	1114856.C496_00475	5.06e-09	63.0	arCOG10716@1|root,arCOG10666@2157|Archaea,2XWHR@28890|Euryarchaeota,23VF4@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_2032006_1	545693.BMQ_4327	7.722e-28	120.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,4HH8C@91061|Bacilli,1ZFJ7@1386|Bacillus	91061|Bacilli	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
CH1_k127_2132463_1	665571.STHERM_c14240	8.49e-27	116.0	COG3476@1|root,COG3476@2|Bacteria,2JB1D@203691|Spirochaetes	203691|Spirochaetes	T	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
CH1_k127_2132463_2	304371.MCP_0377	2.074e-26	117.0	COG0705@1|root,COG3582@1|root,arCOG01768@2157|Archaea,arCOG01769@2157|Archaea,2XTJH@28890|Euryarchaeota,2N9X9@224756|Methanomicrobia	224756|Methanomicrobia	E	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
CH1_k127_2152811_0	224719.Abm4_1647	8.869e-25	113.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,23NIY@183925|Methanobacteria	183925|Methanobacteria	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
CH1_k127_2152811_1	243232.MJ_ECS07	6.914e-07	60.0	COG1467@1|root,arCOG04110@2157|Archaea	2157|Archaea	F	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_2161657_3	1500281.JQKZ01000010_gene2325	0.0001884	47.0	COG4430@1|root,COG4430@2|Bacteria,4NNH0@976|Bacteroidetes,1I3IX@117743|Flavobacteriia,3ZR7F@59732|Chryseobacterium	976|Bacteroidetes	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
CH1_k127_2161657_2	47839.CCAU010000019_gene3184	7.154e-10	66.0	2AVHB@1|root,31M9R@2|Bacteria,2IMW9@201174|Actinobacteria,23A76@1762|Mycobacteriaceae	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
CH1_k127_2161657_1	593750.Metfor_0576	1.817e-32	138.0	arCOG08211@1|root,arCOG08211@2157|Archaea,2XW85@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_2161657_0	1120949.KB903333_gene1518	4.453e-101	347.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4D8WS@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CH1_k127_2222256_0	269797.Mbar_A2814	1.946e-46	172.0	COG1881@1|root,arCOG04702@2157|Archaea,2XXMX@28890|Euryarchaeota,2N9VT@224756|Methanomicrobia	224756|Methanomicrobia	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
CH1_k127_2222256_2	387631.Asulf_00527	1.925e-18	92.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,245T9@183980|Archaeoglobi	183980|Archaeoglobi	K	PFAM Fibronectin-binding A	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
CH1_k127_2222256_1	1229909.NSED_04975	9.237e-20	105.0	COG1361@1|root,arCOG04500@1|root,arCOG02079@2157|Archaea,arCOG04500@2157|Archaea	2157|Archaea	O	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CARDB,NosD,S_layer_C
CH1_k127_225097_0	555088.DealDRAFT_2903	2.112e-125	417.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,42K30@68298|Syntrophomonadaceae	186801|Clostridia	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CH1_k127_225097_1	593750.Metfor_1459	5.248e-13	69.0	COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
CH1_k127_2297358_0	243164.DET0612	4.379e-113	380.0	COG1243@1|root,COG1243@2|Bacteria,2G5ZZ@200795|Chloroflexi,34CU0@301297|Dehalococcoidia	301297|Dehalococcoidia	BK	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
CH1_k127_2335461_0	521045.Kole_0161	6.23e-35	144.0	COG0434@1|root,COG0434@2|Bacteria,2GDB3@200918|Thermotogae	200918|Thermotogae	S	TIGRFAM membrane complex biogenesis protein, BtpA family	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
CH1_k127_2335461_1	395965.Msil_3711	5.626e-30	126.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria,3N9TT@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CH1_k127_245601_0	797209.ZOD2009_03290	5.708e-19	96.0	arCOG02888@1|root,arCOG02888@2157|Archaea,2XTJG@28890|Euryarchaeota,23SIG@183963|Halobacteria	183963|Halobacteria	E	Succinylglutamate desuccinylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
CH1_k127_258000_1	391623.TERMP_00885	1.198e-27	117.0	COG0463@1|root,arCOG00895@2157|Archaea,2Y66T@28890|Euryarchaeota,2454F@183968|Thermococci	183968|Thermococci	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CH1_k127_258000_0	391623.TERMP_00886	3.677e-77	271.0	COG0438@1|root,arCOG01403@2157|Archaea,2Y667@28890|Euryarchaeota,24532@183968|Thermococci	183968|Thermococci	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CH1_k127_258000_2	224719.Abm4_0159	9.271e-13	79.0	COG0463@1|root,COG1215@1|root,arCOG01381@2157|Archaea,arCOG01389@2157|Archaea,2XVM0@28890|Euryarchaeota,23NYJ@183925|Methanobacteria	183925|Methanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CH1_k127_258000_3	436308.Nmar_1457	2.83e-05	51.0	arCOG01778@1|root,arCOG01778@2157|Archaea,41SXW@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
CH1_k127_272476_0	558152.IQ37_11055	8.798e-18	87.0	COG4119@1|root,COG4119@2|Bacteria,4NRRR@976|Bacteroidetes,1I9FM@117743|Flavobacteriia,3ZRN9@59732|Chryseobacterium	976|Bacteroidetes	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CH1_k127_2746524_4	1121468.AUBR01000011_gene2487	7.894e-07	59.0	28JPR@1|root,2Z9FQ@2|Bacteria,1UN7K@1239|Firmicutes,24EG6@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_2746524_3	243232.MJ_1437	1.437e-12	76.0	COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,23QPZ@183939|Methanococci	183939|Methanococci	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CH1_k127_2746524_0	1121324.CLIT_13c01280	5.273e-36	143.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia	186801|Clostridia	F	cytidine and deoxycytidylate deaminase zinc-binding region	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
CH1_k127_2746524_1	1382304.JNIL01000001_gene837	1.002e-24	107.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,4HKKX@91061|Bacilli	91061|Bacilli	O	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CH1_k127_2746524_2	679926.Mpet_0718	1.682e-21	96.0	COG4802@1|root,arCOG01099@2157|Archaea,2Y0XX@28890|Euryarchaeota,2NA12@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
CH1_k127_2772174_1	1365176.N186_07010	6.89e-26	112.0	COG1418@1|root,arCOG01860@2157|Archaea,2XQDI@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
CH1_k127_2772174_0	237368.SCABRO_01045	9.101e-108	360.0	COG0436@1|root,COG0436@2|Bacteria,2IX5E@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CH1_k127_2772174_3	759914.BP951000_1073	4.272e-10	63.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,2JAHR@203691|Spirochaetes	203691|Spirochaetes	E	Chorismate mutase type II	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDT
CH1_k127_2799951_1	419665.Maeo_1057	2.021e-23	107.0	COG1590@1|root,arCOG04156@2157|Archaea,2XWQD@28890|Euryarchaeota,23QTQ@183939|Methanococci	183939|Methanococci	J	S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72	taw3	-	2.1.1.282	ko:K15450	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TYW3
CH1_k127_2799951_0	351160.LRC17	3.639e-105	352.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,2N934@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ-1	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
CH1_k127_2799951_2	868595.Desca_0147	3.633e-18	89.0	COG0778@1|root,COG0778@2|Bacteria,1V4UA@1239|Firmicutes,24EVR@186801|Clostridia,266UF@186807|Peptococcaceae	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
CH1_k127_2827025_3	589924.Ferp_1963	1.88e-25	110.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2471N@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CH1_k127_2827025_6	529709.PYCH_02540	5.18e-20	94.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,243ZW@183968|Thermococci	183968|Thermococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CH1_k127_2827025_8	387631.Asulf_00628	1.193e-12	73.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,246C1@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18,Ribosomal_L27A
CH1_k127_2827025_2	386456.JQKN01000001_gene1729	2.006e-26	117.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,23NZ9@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,RNA_pol_A_bac,RNA_pol_L
CH1_k127_2827025_7	263820.PTO1221	1.135e-18	92.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,241PM@183967|Thermoplasmata	183967|Thermoplasmata	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
CH1_k127_2827025_5	399550.Smar_0813	1.16e-20	98.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CH1_k127_2827025_1	1220534.B655_1480	4.632e-27	117.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,23P1M@183925|Methanobacteria	183925|Methanobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
CH1_k127_2827025_0	186497.PF1862	3.209e-44	166.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,242KI@183968|Thermococci	183968|Thermococci	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
CH1_k127_2827025_9	490899.DKAM_1408	8.574e-11	66.0	COG2139@1|root,arCOG04129@2157|Archaea,2XQR1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
CH1_k127_2827025_4	1163730.FFONT_0460	8.631e-21	93.0	COG1644@1|root,arCOG04244@2157|Archaea,2XR60@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
CH1_k127_2834615_0	411154.GFO_2798	8.114e-75	260.0	COG0018@1|root,COG0018@2|Bacteria,4NE7Q@976|Bacteroidetes,1HY2B@117743|Flavobacteriia	976|Bacteroidetes	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CH1_k127_2977659_1	304371.MCP_1674	5.134e-40	159.0	COG0077@1|root,arCOG00255@2157|Archaea,2XTAI@28890|Euryarchaeota,2N9DQ@224756|Methanomicrobia	224756|Methanomicrobia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
CH1_k127_2977659_0	192952.MM_2556	2.886e-143	467.0	COG0513@1|root,arCOG00558@2157|Archaea,2XUS4@28890|Euryarchaeota,2N99K@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
CH1_k127_3077220_1	1227497.C491_21711	1.235e-32	140.0	COG0628@1|root,arCOG02642@2157|Archaea,2XU4M@28890|Euryarchaeota,23S3F@183963|Halobacteria	183963|Halobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CH1_k127_3077220_0	243232.MJ_0667	2.063e-45	172.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,23QPY@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	-	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006196,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009125,GO:0009126,GO:0009128,GO:0009150,GO:0009154,GO:0009158,GO:0009161,GO:0009166,GO:0009167,GO:0009169,GO:0009259,GO:0009261,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
CH1_k127_3117525_0	908937.Prede_0136	1.836e-32	133.0	COG0641@1|root,COG0641@2|Bacteria,4NG1N@976|Bacteroidetes,2FMBY@200643|Bacteroidia	976|Bacteroidetes	C	Anaerobic sulfatase maturase	atsB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CH1_k127_3159554_0	1196323.ALKF01000200_gene2711	1.493e-29	127.0	COG0546@1|root,COG0546@2|Bacteria,1V3WR@1239|Firmicutes,4HGSI@91061|Bacilli,26QR0@186822|Paenibacillaceae	91061|Bacilli	S	hydrolase	yjcH1	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CH1_k127_3159554_1	263820.PTO1500	1.681e-05	48.0	COG1533@1|root,arCOG01290@2157|Archaea,2XY2A@28890|Euryarchaeota,241RK@183967|Thermoplasmata	183967|Thermoplasmata	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CH1_k127_3486724_1	679926.Mpet_1697	2.512e-35	142.0	COG0341@1|root,arCOG03054@2157|Archaea,2XTMX@28890|Euryarchaeota,2N9GN@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in protein export	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CH1_k127_3486724_0	523845.AQXV01000033_gene452	1.239e-64	240.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,23Q41@183939|Methanococci	183939|Methanococci	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CH1_k127_3486724_2	1041930.Mtc_0547	4.214e-10	66.0	COG2244@1|root,arCOG02209@2157|Archaea,2XVVS@28890|Euryarchaeota,2N9KR@224756|Methanomicrobia	224756|Methanomicrobia	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
CH1_k127_3508466_0	269799.Gmet_1613	5.045e-103	361.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,43TKN@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
CH1_k127_3508466_1	224325.AF_2040	3.121e-12	71.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,24676@183980|Archaeoglobi	183980|Archaeoglobi	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
CH1_k127_3715814_1	1235802.C823_01246	4.337e-13	81.0	COG0535@1|root,COG0535@2|Bacteria,1UET7@1239|Firmicutes,24F49@186801|Clostridia	186801|Clostridia	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CH1_k127_3715814_3	351160.RCIX2746	9.172e-06	57.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2N9P3@224756|Methanomicrobia	224756|Methanomicrobia	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
CH1_k127_3715814_2	999630.TUZN_0492	6.956e-07	61.0	COG0704@1|root,arCOG00318@2157|Archaea,2XQIE@28889|Crenarchaeota	28889|Crenarchaeota	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
CH1_k127_3715814_0	1110502.TMO_1345	3.191e-48	186.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,2VEZT@28211|Alphaproteobacteria,2JR2N@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3
CH1_k127_3845070_2	441620.Mpop_4492	0.0002896	45.0	COG0287@1|root,COG0287@2|Bacteria,1Q8CX@1224|Proteobacteria,2VEJG@28211|Alphaproteobacteria,1JTI3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
CH1_k127_3845070_1	1121405.dsmv_2533	4.64e-14	78.0	COG2606@1|root,COG2606@2|Bacteria,1R9YR@1224|Proteobacteria,42SA8@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	YbaK proline--tRNA ligase associated domain protein	yeaK	GO:0002161,GO:0002196,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006417,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0045727,GO:0045903,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:2000112	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
CH1_k127_3845070_0	1605.Lani381_0112	1.718e-19	97.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,4HA9B@91061|Bacilli,3F4E1@33958|Lactobacillaceae	91061|Bacilli	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
CH1_k127_395348_0	42256.RradSPS_0124	6.314e-64	229.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CQF1@84995|Rubrobacteria	84995|Rubrobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
CH1_k127_395348_2	484019.THA_1600	7.886e-30	122.0	COG0720@1|root,COG0720@2|Bacteria,2GD1V@200918|Thermotogae	200918|Thermotogae	H	PFAM 6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
CH1_k127_395348_3	870187.Thini_4510	5.757e-09	63.0	2C9Y3@1|root,33JDQ@2|Bacteria,1NQEK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_395348_1	868131.MSWAN_0004	5.447e-50	184.0	COG1704@1|root,arCOG04574@2157|Archaea,2XXB9@28890|Euryarchaeota,23PHV@183925|Methanobacteria	183925|Methanobacteria	S	PFAM LemA	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CH1_k127_3963488_0	330779.Saci_1274	7.444e-14	86.0	COG1287@1|root,arCOG02044@2157|Archaea,2XQVE@28889|Crenarchaeota	28889|Crenarchaeota	M	Oligosaccharyl transferase, STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
CH1_k127_4001861_3	351160.RRC93	1.548e-12	70.0	arCOG01059@1|root,arCOG01059@2157|Archaea,2Y0H1@28890|Euryarchaeota,2N9Y0@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_4001861_0	877415.JNJQ01000037_gene1890	8.704e-164	526.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,3VP5X@526524|Erysipelotrichia	526524|Erysipelotrichia	J	Psort location Cytoplasmic, score 10.00	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
CH1_k127_4001861_2	523850.TON_0564	3.683e-18	93.0	COG2129@1|root,arCOG01145@2157|Archaea,2Y30B@28890|Euryarchaeota,245B3@183968|Thermococci	183968|Thermococci	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	-
CH1_k127_4001861_1	1894.JOER01000022_gene3883	2.465e-64	224.0	COG0574@1|root,COG0717@1|root,COG0574@2|Bacteria,COG0717@2|Bacteria,2GUMZ@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the PEP-utilizing enzyme family	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CH1_k127_4001861_4	1278073.MYSTI_02052	1.546e-08	64.0	COG0535@1|root,COG0535@2|Bacteria,1PN12@1224|Proteobacteria,437WF@68525|delta/epsilon subdivisions,2X363@28221|Deltaproteobacteria,2YUG0@29|Myxococcales	28221|Deltaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
CH1_k127_4001861_5	768679.TTX_0564	7.346e-07	55.0	COG0105@1|root,arCOG04313@2157|Archaea,2XQEV@28889|Crenarchaeota	28889|Crenarchaeota	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
CH1_k127_4072408_3	1247963.JPHU01000009_gene2417	9.707e-07	61.0	COG0717@1|root,COG0717@2|Bacteria,1MVDH@1224|Proteobacteria,2TR5U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	2-deoxycytidine 5-triphosphate deaminase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
CH1_k127_4072408_2	240302.BN982_04213	4.379e-62	224.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,3NDQ7@45667|Halobacillus	91061|Bacilli	E	Pyridoxal-phosphate dependent enzyme	cysK	GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0032991,GO:0032993,GO:0036094,GO:0042127,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043388,GO:0043436,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0065007,GO:0065009,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1904796,GO:1904798,GO:2000677,GO:2000679	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CH1_k127_4072408_1	309799.DICTH_1585	3.211e-155	502.0	COG0215@1|root,COG0215@2|Bacteria	2|Bacteria	J	cysteine-tRNA ligase activity	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
CH1_k127_4072408_0	1094980.Mpsy_0328	2.012e-231	721.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,2N9IP@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
CH1_k127_4105274_1	368407.Memar_1809	1.04e-57	213.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,2NAG2@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CH1_k127_4105274_0	3659.XP_004149350.1	5.895e-105	349.0	COG0458@1|root,KOG0370@2759|Eukaryota,37MJ1@33090|Viridiplantae,3GGQ1@35493|Streptophyta,4JMU1@91835|fabids	35493|Streptophyta	EF	Belongs to the ATCase OTCase family	PYRB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009267,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009987,GO:0009991,GO:0016036,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0034654,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CH1_k127_433809_1	192952.MM_0963	5.358e-46	170.0	COG3476@1|root,arCOG04434@2157|Archaea,2XYQD@28890|Euryarchaeota,2NAZX@224756|Methanomicrobia	224756|Methanomicrobia	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
CH1_k127_433809_2	374847.Kcr_0984	2.056e-27	118.0	COG3620@1|root,arCOG00608@2157|Archaea	2157|Archaea	K	transcriptional regulator with C-terminal CBS domains	cbs8	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A2079	CBS,HTH_3,HTH_31
CH1_k127_433809_0	1459636.NTE_01726	8.118e-73	254.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CH1_k127_4355509_0	644281.MFS40622_0054	1.219e-19	96.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,23QBC@183939|Methanococci	183939|Methanococci	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
CH1_k127_4355509_1	368407.Memar_1791	3.375e-16	84.0	COG3364@1|root,arCOG04417@2157|Archaea,2Y0WK@28890|Euryarchaeota,2N9ZI@224756|Methanomicrobia	224756|Methanomicrobia	S	Zn-ribbon containing protein	-	-	-	ko:K07163	-	-	-	-	ko00000	-	-	-	DUF2072
CH1_k127_4355509_2	679926.Mpet_0743	2.709e-09	63.0	COG3365@1|root,arCOG04416@2157|Archaea,2XX2F@28890|Euryarchaeota,2N9XF@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2073)	-	-	-	ko:K09743	-	-	-	-	ko00000	-	-	-	DUF2073
CH1_k127_4416157_1	224325.AF_0932	1.946e-32	134.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,246Y6@183980|Archaeoglobi	183980|Archaeoglobi	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
CH1_k127_4416157_0	604354.TSIB_0147	7.274e-80	282.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242UT@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
CH1_k127_4416157_2	436308.Nmar_1525	4.024e-07	52.0	COG0042@1|root,arCOG00604@2157|Archaea	2157|Archaea	J	Dihydrouridine synthase (Dus)	dusA1	-	-	-	-	-	-	-	-	-	-	-	Dus
CH1_k127_447509_0	1321778.HMPREF1982_00173	5.086e-55	198.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,24AKU@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator	-	-	-	ko:K08153	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8	-	-	MFS_1,Sugar_tr
CH1_k127_447509_1	529507.PMI1003	0.0005288	51.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1RRE9@1236|Gammaproteobacteria,3Z257@583|Proteus	1236|Gammaproteobacteria	E	DNA polymerase alpha chain like domain	ycdX	GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0008150,GO:0008270,GO:0009987,GO:0016787,GO:0016788,GO:0040011,GO:0042578,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K04477	-	-	-	-	ko00000	-	-	-	PHP
CH1_k127_4500893_0	247490.KSU1_C0073	9.926e-199	655.0	COG1328@1|root,COG1328@2|Bacteria	2|Bacteria	F	CTP reductase activity	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
CH1_k127_4500893_1	673860.AciM339_0526	6.395e-28	119.0	COG1180@1|root,arCOG00952@2157|Archaea,2XW90@28890|Euryarchaeota,3F2VD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CH1_k127_4522326_0	593117.TGAM_0126	9.516e-62	220.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,24309@183968|Thermococci	183968|Thermococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
CH1_k127_4522326_2	155864.EDL933_2243	8.068e-23	106.0	COG0558@1|root,COG0558@2|Bacteria,1RE0I@1224|Proteobacteria,1S2UQ@1236|Gammaproteobacteria,3XR1R@561|Escherichia	1236|Gammaproteobacteria	I	phosphotransferase activity, for other substituted phosphate groups	ynbA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CH1_k127_4522326_3	1203076.CAKF01000010_gene197	1.562e-21	106.0	COG0575@1|root,COG0575@2|Bacteria,1UPNB@1239|Firmicutes,4IV81@91061|Bacilli,3F4AF@33958|Lactobacillaceae	91061|Bacilli	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CH1_k127_4522326_4	331678.Cphamn1_0250	7.226e-09	61.0	COG0736@1|root,COG0736@2|Bacteria,1FE6X@1090|Chlorobi	1090|Chlorobi	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CH1_k127_4522326_1	269799.Gmet_1613	2.687e-23	104.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,43TKN@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
CH1_k127_479337_1	403833.Pmob_0207	9.446e-18	85.0	COG0064@1|root,COG0064@2|Bacteria,2GCBS@200918|Thermotogae	200918|Thermotogae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
CH1_k127_479337_2	1094980.Mpsy_1915	2.368e-11	72.0	COG0640@1|root,arCOG01686@2157|Archaea,2XX9R@28890|Euryarchaeota,2N9WK@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
CH1_k127_479337_0	765420.OSCT_1927	6.705e-21	102.0	COG2968@1|root,COG2968@2|Bacteria,2G6UC@200795|Chloroflexi,377CQ@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
CH1_k127_4814344_0	3712.Bo8g010790.1	1.242e-05	49.0	COG0468@1|root,KOG1433@2759|Eukaryota,37M04@33090|Viridiplantae,3GEWD@35493|Streptophyta,3HYDD@3699|Brassicales	35493|Streptophyta	L	DNA repair protein RAD51 homolog	-	GO:0000003,GO:0000150,GO:0000217,GO:0000280,GO:0000400,GO:0000707,GO:0000724,GO:0000725,GO:0000730,GO:0002831,GO:0002833,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016444,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0022414,GO:0022607,GO:0031347,GO:0031349,GO:0032101,GO:0032103,GO:0032991,GO:0033061,GO:0033063,GO:0033554,GO:0034622,GO:0034641,GO:0035825,GO:0042148,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043900,GO:0043902,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0045003,GO:0046483,GO:0048285,GO:0048518,GO:0048583,GO:0048584,GO:0050789,GO:0050896,GO:0051321,GO:0051716,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0071704,GO:0071824,GO:0071840,GO:0080134,GO:0090304,GO:0090735,GO:0097159,GO:0140013,GO:0140097,GO:1900424,GO:1900426,GO:1901360,GO:1901363,GO:1903046	-	ko:K10871	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	Rad51
CH1_k127_4814344_1	634498.mru_0169	0.0002902	47.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
CH1_k127_4863316_2	330779.Saci_0697	6.253e-09	60.0	COG2075@1|root,arCOG01950@2157|Archaea,2XR6Q@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
CH1_k127_4863316_1	374847.Kcr_1018	3.199e-19	90.0	COG2053@1|root,arCOG04314@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
CH1_k127_4863316_0	1056495.Calag_0547	5.367e-25	107.0	COG1358@1|root,arCOG01751@2157|Archaea,2XQH4@28889|Crenarchaeota	28889|Crenarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
CH1_k127_4891306_3	406327.Mevan_0084	0.0003345	45.0	COG0640@1|root,arCOG01446@2157|Archaea,2XWN0@28890|Euryarchaeota	28890|Euryarchaeota	K	TIGRFAM CRISPR locus-related DNA-binding	-	-	-	ko:K07725	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	Cas_APE2256,HTH_24,HTH_5
CH1_k127_4891306_2	388739.RSK20926_04387	0.000172	49.0	COG1051@1|root,COG1051@2|Bacteria,1N1KH@1224|Proteobacteria,2UA1K@28211|Alphaproteobacteria,2P3JX@2433|Roseobacter	28211|Alphaproteobacteria	F	Belongs to the Nudix hydrolase family	nudF	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CH1_k127_4891306_1	1156937.MFUM_700041	4.963e-42	167.0	COG0329@1|root,COG0329@2|Bacteria,46SDY@74201|Verrucomicrobia,37G2R@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	EM	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CH1_k127_4891306_0	761193.Runsl_3925	7.008e-47	171.0	COG0739@1|root,COG0739@2|Bacteria,4NN4Q@976|Bacteroidetes,47PNX@768503|Cytophagia	976|Bacteroidetes	M	PFAM Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CH1_k127_4959186_1	224325.AF_1532	1.756e-06	53.0	COG1873@1|root,arCOG02155@2157|Archaea,2XZ54@28890|Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel	-	-	-	-	-	-	-	-	-	-	-	-	PRC
CH1_k127_4959186_0	195522.BD01_0924	5.544e-59	211.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
CH1_k127_5121162_0	192952.MM_1970	9.072e-55	209.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
CH1_k127_5121162_2	573063.Metin_0775	3.191e-14	74.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,23R97@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein S27E	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
CH1_k127_5121162_1	1041930.Mtc_1025	7.632e-17	89.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,2N93I@224756|Methanomicrobia	224756|Methanomicrobia	J	Translation initiation factor 2 alpha subunit	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
CH1_k127_5121162_3	746697.Aeqsu_0959	1.306e-11	66.0	COG2076@1|root,COG2076@2|Bacteria	2|Bacteria	P	Multidrug Resistance protein	arnE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03297,ko:K12962	ko01503,map01503	M00721	-	-	ko00000,ko00001,ko00002,ko01005,ko02000	2.A.7.1,2.A.7.22	-	iEC55989_1330.EC55989_2505,iECABU_c1320.ECABU_c25920,iLF82_1304.LF82_3058,iNRG857_1313.NRG857_11450,ic_1306.c2800	EamA,Multi_Drug_Res
CH1_k127_5160864_1	260799.BAS3130	2.276e-55	208.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,4HAWF@91061|Bacilli,1ZDID@1386|Bacillus	91061|Bacilli	J	histidyl-tRNA synthetase	-	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
CH1_k127_5160864_0	1499967.BAYZ01000073_gene2025	7.154e-111	373.0	COG0106@1|root,COG0139@1|root,COG0106@2|Bacteria,COG0139@2|Bacteria,2NPDP@2323|unclassified Bacteria	2|Bacteria	E	Phosphoribosyl-AMP cyclohydrolase	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0003949,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16	ko:K01496,ko:K01497,ko:K01814,ko:K11755	ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024	M00026,M00125	R00425,R04035,R04037,R04640	RC00002,RC00293,RC00945,RC01055,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iHN637.CLJU_RS05760,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186	His_biosynth,PRA-CH,PRA-PH,SseB
CH1_k127_5160864_2	227086.JGI_V11_92714	2.783e-06	56.0	COG0040@1|root,KOG2831@2759|Eukaryota	2759|Eukaryota	E	ATP phosphoribosyltransferase activity	HIS1	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K08736	ko00340,ko01100,ko01110,ko01230,ko01524,ko03430,ko05200,ko05210,map00340,map01100,map01110,map01230,map01524,map03430,map05200,map05210	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	HisG,HisG_C
CH1_k127_5207508_1	5762.XP_002679146.1	3.635e-273	856.0	COG1372@1|root,2QRRC@2759|Eukaryota	2759|Eukaryota	L	reductase	-	GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	-	-	-	-	-	-	-	-	-	-	Ribonuc_red_lgC
CH1_k127_5207508_2	596330.HMPREF0628_0427	3.513e-45	168.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,22HHT@1570339|Peptoniphilaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
CH1_k127_5207508_3	1235803.C825_00482	1.757e-33	136.0	COG0406@1|root,COG0406@2|Bacteria,4NPZ0@976|Bacteroidetes,2FPTF@200643|Bacteroidia,22XV2@171551|Porphyromonadaceae	976|Bacteroidetes	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634,ko:K15640	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
CH1_k127_5207508_4	931276.Cspa_c37850	0.0003761	47.0	2ED1S@1|root,336YP@2|Bacteria,1VJRI@1239|Firmicutes,24UCF@186801|Clostridia,36T2P@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_5207508_0	351627.Csac_1955	0.0	1095.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,42F5B@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CH1_k127_5248416_0	647113.Metok_0123	7.685e-14	77.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
CH1_k127_5248416_1	1006006.Mcup_1864	0.0001065	48.0	COG2092@1|root,arCOG01988@2157|Archaea,2XR49@28889|Crenarchaeota	28889|Crenarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
CH1_k127_5362263_0	555779.Dthio_PD2268	1.134e-24	120.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42QFH@68525|delta/epsilon subdivisions,2WKWR@28221|Deltaproteobacteria,2M7U5@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Glycos_transf_2,Radical_SAM
CH1_k127_5423679_0	521045.Kole_2170	2.118e-09	61.0	COG1141@1|root,COG1141@2|Bacteria,2GDGB@200918|Thermotogae	200918|Thermotogae	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
CH1_k127_5423679_1	400668.Mmwyl1_4460	2.999e-07	60.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,1RS6X@1236|Gammaproteobacteria,1XITG@135619|Oceanospirillales	135619|Oceanospirillales	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
CH1_k127_5446764_0	667014.Thein_1227	4.215e-162	530.0	COG0188@1|root,COG0188@2|Bacteria,2GHG4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CH1_k127_551840_1	90675.XP_010488908.1	0.0007856	46.0	28KFV@1|root,2QSX2@2759|Eukaryota,37IZS@33090|Viridiplantae,3G7YA@35493|Streptophyta,3HNQF@3699|Brassicales	35493|Streptophyta	T	Vacuolar-sorting receptor	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005773,GO:0005794,GO:0005802,GO:0006605,GO:0006623,GO:0006810,GO:0006886,GO:0007034,GO:0008104,GO:0008150,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0031410,GO:0031982,GO:0031984,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072594,GO:0072665,GO:0072666,GO:0097708,GO:0098791	-	-	-	-	-	-	-	-	-	-	PA,cEGF
CH1_k127_551840_0	647113.Metok_1389	3.683e-63	232.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,23Q03@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rad17
CH1_k127_5573515_0	243274.THEMA_04630	3.977e-50	184.0	COG2768@1|root,COG2768@2|Bacteria,2GC95@200918|Thermotogae	200918|Thermotogae	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
CH1_k127_5573515_2	574375.BAGA_28920	9.616e-10	64.0	2BRH5@1|root,32KG4@2|Bacteria,1U5II@1239|Firmicutes,4IF9B@91061|Bacilli,1ZMTR@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_5573515_1	879212.DespoDRAFT_03137	1.91e-18	91.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42TW3@68525|delta/epsilon subdivisions,2WPZS@28221|Deltaproteobacteria,2MKHQ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
CH1_k127_5591111_1	135651.CBN13486	0.0004488	47.0	COG1594@1|root,KOG2907@2759|Eukaryota,3A3MW@33154|Opisthokonta,3BRQ2@33208|Metazoa,3D763@33213|Bilateria,40F0S@6231|Nematoda,1KXD5@119089|Chromadorea,412F5@6236|Rhabditida	33208|Metazoa	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	ZNRD1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005736,GO:0006139,GO:0006351,GO:0006352,GO:0006353,GO:0006360,GO:0006361,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019222,GO:0019438,GO:0030880,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0040029,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0045815,GO:0046483,GO:0048518,GO:0050789,GO:0055029,GO:0060255,GO:0061695,GO:0065007,GO:0070013,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	-	ko:K03000	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021	-	-	-	TFIIS_C
CH1_k127_5591111_0	521003.COLINT_02543	0.0001352	52.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4CUG1@84998|Coriobacteriia	84998|Coriobacteriia	H	tRNA nucleotidyltransferase poly(A) polymerase	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
CH1_k127_5613341_2	1306947.ARQD01000001_gene989	1.851e-06	52.0	COG0177@1|root,COG0177@2|Bacteria,2NP8N@2323|unclassified Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2,4.2.99.18	ko:K01142,ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CH1_k127_5613341_1	877455.Metbo_0203	2.09e-22	100.0	COG1594@1|root,arCOG00579@2157|Archaea,2XZ6S@28890|Euryarchaeota,23P4D@183925|Methanobacteria	183925|Methanobacteria	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
CH1_k127_5613341_0	1449336.JQLO01000001_gene1881	6.266e-50	181.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,4HAI0@91061|Bacilli,27FVE@186828|Carnobacteriaceae	91061|Bacilli	P	Heavy-metal-associated domain	copA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CH1_k127_56479_0	1227500.C494_15268	6.966e-28	129.0	arCOG02542@1|root,arCOG07560@1|root,arCOG02542@2157|Archaea,arCOG07560@2157|Archaea,2Y82Y@28890|Euryarchaeota,24140@183963|Halobacteria	183963|Halobacteria	S	The GLUG motif	-	-	-	-	-	-	-	-	-	-	-	-	Glug
CH1_k127_5868400_10	351160.RCIX2557	1.003e-09	63.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,2N9HR@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,RS4NT,Ribosomal_S4e,S4
CH1_k127_5868400_6	1220534.B655_1500	6.916e-25	108.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,23P4Z@183925|Methanobacteria	183925|Methanobacteria	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
CH1_k127_5868400_4	768672.Desfe_1276	4.787e-28	118.0	COG0093@1|root,arCOG04095@2157|Archaea,2XQPU@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
CH1_k127_5868400_8	565033.GACE_2230	6.385e-21	96.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,24740@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
CH1_k127_5868400_3	243232.MJ_0463	2.154e-32	128.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23R03@183939|Methanococci	183939|Methanococci	J	Belongs to the SUI1 family	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
CH1_k127_5868400_2	1343739.PAP_01740	5.964e-42	163.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,243EH@183968|Thermococci	183968|Thermococci	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
CH1_k127_5868400_11	1041930.Mtc_1327	2.8e-08	61.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,2N9UR@224756|Methanomicrobia	224756|Methanomicrobia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
CH1_k127_5868400_5	529709.PYCH_01410	8.827e-26	111.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,24405@183968|Thermococci	183968|Thermococci	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
CH1_k127_5868400_1	565033.GACE_2224	3.004e-50	187.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,245UM@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
CH1_k127_5868400_9	1006006.Mcup_1965	1.636e-12	70.0	COG0089@1|root,arCOG04072@2157|Archaea,2XR92@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
CH1_k127_5868400_7	269797.Mbar_A0109	2.78e-22	107.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,2N9DG@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
CH1_k127_5868400_0	1343739.PAP_01710	1.722e-63	229.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,2430N@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
CH1_k127_6096850_0	693661.Arcve_0786	1.508e-141	462.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
CH1_k127_6206165_0	374847.Kcr_1199	5.337e-167	556.0	COG0060@1|root,arCOG00807@2157|Archaea	2157|Archaea	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
CH1_k127_6243336_1	909663.KI867150_gene2301	1.698e-10	70.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CH1_k127_6243336_0	224719.Abm4_0318	8.093e-32	134.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,23NVE@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
CH1_k127_6243336_2	1121451.DESAM_20350	2.407e-10	64.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1N2VJ@1224|Proteobacteria,43C4Q@68525|delta/epsilon subdivisions,2WREQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1,Glycos_transf_2
CH1_k127_6361821_2	552811.Dehly_0315	3.085e-09	63.0	COG1278@1|root,COG1278@2|Bacteria,2G79W@200795|Chloroflexi,34DCQ@301297|Dehalococcoidia	200795|Chloroflexi	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
CH1_k127_6361821_0	877455.Metbo_0939	2.868e-93	325.0	COG1107@1|root,arCOG00429@2157|Archaea,2XTZ2@28890|Euryarchaeota,23NQA@183925|Methanobacteria	183925|Methanobacteria	L	RecJ-like	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	S1,tRNA_anti-codon
CH1_k127_6361821_1	374847.Kcr_1086	2.392e-21	103.0	COG1407@1|root,arCOG01150@2157|Archaea	2157|Archaea	S	Metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
CH1_k127_6361821_3	391735.Veis_1659	1.351e-05	53.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,4ABF6@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM Phospholipid glycerol acyltransferase	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	Acyltransferase,MFS_1
CH1_k127_649360_2	90675.XP_010423410.1	1.614e-10	62.0	COG1899@1|root,KOG2924@2759|Eukaryota,37M1S@33090|Viridiplantae,3GAK2@35493|Streptophyta,3HT4A@3699|Brassicales	35493|Streptophyta	O	Deoxyhypusine synthase	DHS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009553,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0032501,GO:0032502,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0048229,GO:0048856,GO:0051604,GO:0071704,GO:1901564	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
CH1_k127_649360_0	1122149.BACN01000083_gene1099	8.338e-97	329.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,4HCNM@91061|Bacilli,3F43F@33958|Lactobacillaceae	91061|Bacilli	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CH1_k127_649360_1	269797.Mbar_A1642	9.616e-41	158.0	COG1796@1|root,arCOG00305@2157|Archaea,2XT14@28890|Euryarchaeota,2N90T@224756|Methanomicrobia	224756|Methanomicrobia	L	Helix-hairpin-helix domain	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
CH1_k127_6739230_2	573063.Metin_0453	2.338e-09	67.0	COG1082@1|root,arCOG01895@2157|Archaea,2XW3E@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CH1_k127_6739230_0	926561.KB900617_gene2319	1.94e-31	134.0	COG2221@1|root,COG4624@1|root,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,25KFH@186801|Clostridia,3WAGS@53433|Halanaerobiales	186801|Clostridia	C	Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,PAS
CH1_k127_6739230_4	944565.HMPREF9127_0418	0.0007138	50.0	COG0500@1|root,COG2226@2|Bacteria,1TR3E@1239|Firmicutes,249HI@186801|Clostridia,22HKH@1570339|Peptoniphilaceae	186801|Clostridia	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CH1_k127_6739230_3	1234664.AMRO01000050_gene365	0.0006044	48.0	COG1247@1|root,COG1247@2|Bacteria,1VAAC@1239|Firmicutes,4HKUR@91061|Bacilli,1WG1C@129337|Geobacillus	91061|Bacilli	M	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
CH1_k127_6739230_1	1282887.AUJG01000001_gene1594	1.041e-11	71.0	COG0454@1|root,COG0456@2|Bacteria,1V77V@1239|Firmicutes,24MDJ@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CH1_k127_6754984_2	1123009.AUID01000011_gene2277	2.488e-08	61.0	2EPF5@1|root,33H1T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_6754984_0	1219065.VPR01S_25_00540	9.153e-47	179.0	COG0758@1|root,COG0758@2|Bacteria,1R5PU@1224|Proteobacteria,1S1AD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	LU	DNA recombination-mediator protein A	-	-	-	-	-	-	-	-	-	-	-	-	DNA_processg_A
CH1_k127_6754984_3	745718.JADT01000019_gene1519	3.214e-06	49.0	COG0847@1|root,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
CH1_k127_6800590_1	387631.Asulf_02229	6.227e-48	180.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,245ZG@183980|Archaeoglobi	183980|Archaeoglobi	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
CH1_k127_6800590_0	391623.TERMP_00163	1.064e-59	215.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
CH1_k127_6800590_2	868131.MSWAN_0460	1.138e-39	154.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,23P36@183925|Methanobacteria	183925|Methanobacteria	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6
CH1_k127_6805603_0	1220534.B655_1412	1.792e-107	360.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,23NVS@183925|Methanobacteria	183925|Methanobacteria	L	helicase	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
CH1_k127_6809349_1	647113.Metok_0859	1.227e-06	59.0	COG1989@1|root,arCOG02298@2157|Archaea,2Y64R@28890|Euryarchaeota,23QES@183939|Methanococci	183939|Methanococci	N	Peptidase A24A, prepilin type IV	flaK	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
CH1_k127_6809349_0	411459.RUMOBE_01669	2.16e-16	86.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,3Y034@572511|Blautia	186801|Clostridia	FG	Psort location Cytoplasmic, score 8.87	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
CH1_k127_6920342_2	456320.Mvol_0646	6.285e-06	59.0	COG1800@1|root,arCOG02545@1|root,arCOG02552@1|root,arCOG04500@1|root,arCOG02545@2157|Archaea,arCOG02552@2157|Archaea,arCOG03419@2157|Archaea,arCOG04500@2157|Archaea,2Y7QQ@28890|Euryarchaeota,23RDP@183939|Methanococci	183939|Methanococci	O	S-layer like family, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_6920342_0	111780.Sta7437_3772	2.913e-14	82.0	COG2894@1|root,COG2894@2|Bacteria,1G2A5@1117|Cyanobacteria,3VHN9@52604|Pleurocapsales	1117|Cyanobacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	minD	GO:0000910,GO:0007049,GO:0008150,GO:0009987,GO:0022402,GO:0032506,GO:0036214,GO:0051179,GO:0051301,GO:0061640	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA,ParA
CH1_k127_6920342_1	247490.KSU1_C1415	6.57e-11	67.0	COG4190@1|root,COG4190@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CH1_k127_6977533_1	313612.L8106_20308	1.054e-13	82.0	COG4301@1|root,COG4301@2|Bacteria,1G4VW@1117|Cyanobacteria,1HF60@1150|Oscillatoriales	1117|Cyanobacteria	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
CH1_k127_6977533_2	1235793.C809_02843	1.384e-05	55.0	COG1378@1|root,COG1378@2|Bacteria,1V2DD@1239|Firmicutes,24BVS@186801|Clostridia,27MUH@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
CH1_k127_6977533_0	523850.TON_1344	1.035e-16	85.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,2433T@183968|Thermococci	183968|Thermococci	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
CH1_k127_6999189_0	386456.JQKN01000008_gene1529	9.069e-224	709.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23NT2@183925|Methanobacteria	183925|Methanobacteria	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
CH1_k127_7043046_0	267377.MMP0044	3.112e-89	308.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,23Q9B@183939|Methanococci	183939|Methanococci	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
CH1_k127_7043046_2	391625.PPSIR1_37254	7.322e-13	73.0	29PVA@1|root,30ATI@2|Bacteria,1QT9G@1224|Proteobacteria,4357I@68525|delta/epsilon subdivisions,2WZIJ@28221|Deltaproteobacteria,2Z285@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_7043046_1	1117319.PSPO_21164	6.363e-19	100.0	COG1404@1|root,COG5183@1|root,COG1404@2|Bacteria,COG5183@2|Bacteria,1MW57@1224|Proteobacteria,1SZIX@1236|Gammaproteobacteria,2Q5F3@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	AO	COG1404 Subtilisin-like serine proteases	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,Peptidase_S8
CH1_k127_7091003_1	269797.Mbar_A3709	2.14e-05	55.0	arCOG01814@1|root,arCOG01814@2157|Archaea,2XT74@28890|Euryarchaeota,2N90N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_7091003_0	269797.Mbar_A3710	6.75e-109	381.0	COG4962@1|root,arCOG01818@2157|Archaea,2XTN5@28890|Euryarchaeota,2N9AG@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
CH1_k127_7107997_2	1123376.AUIU01000013_gene1706	1.597e-21	98.0	COG0682@1|root,COG0682@2|Bacteria,3J0G4@40117|Nitrospirae	40117|Nitrospirae	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CH1_k127_7107997_3	428126.CLOSPI_00928	6.978e-13	73.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,3VR0X@526524|Erysipelotrichia	526524|Erysipelotrichia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
CH1_k127_7107997_0	323259.Mhun_1584	4.142e-64	226.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,2N9QU@224756|Methanomicrobia	224756|Methanomicrobia	E	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
CH1_k127_7107997_1	368408.Tpen_1106	3.027e-22	103.0	COG0512@1|root,arCOG00086@2157|Archaea	2157|Archaea	EH	Glutamine amidotransferase of anthranilate synthase	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.4.2.18,2.6.1.85,4.1.3.27	ko:K01658,ko:K01664,ko:K13497	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01073,R01716	RC00010,RC00440,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3627	GATase
CH1_k127_714617_3	61647.LG71_06055	1.157e-10	63.0	COG1957@1|root,COG1957@2|Bacteria,1N18K@1224|Proteobacteria,1SYNB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Inosine-uridine preferring nucleoside hydrolase	-	-	-	ko:K01250	-	-	-	-	ko00000,ko01000	-	-	-	IU_nuc_hydro
CH1_k127_714617_1	1365176.N186_05245	4.202e-28	125.0	COG0171@1|root,arCOG00069@2157|Archaea,2XQ3J@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
CH1_k127_714617_0	575593.HMPREF0491_00853	1.819e-106	361.0	COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia,27IY6@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C,QRPTase_N
CH1_k127_714617_2	448385.sce3711	3.287e-14	81.0	COG1335@1|root,COG1335@2|Bacteria,1NDJV@1224|Proteobacteria	1224|Proteobacteria	Q	Isochorismatase family	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
CH1_k127_714617_4	562973.HMPREF0059_00440	0.0006659	52.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4D39S@85005|Actinomycetales	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CH1_k127_7188554_0	1052684.PPM_4326	6.799e-13	79.0	COG0535@1|root,COG0535@2|Bacteria,1V5FE@1239|Firmicutes,4HSHA@91061|Bacilli,2707S@186822|Paenibacillaceae	91061|Bacilli	C	Iron-sulfur cluster-binding domain	pqqE	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
CH1_k127_7188554_1	406552.NJ7G_1463	7.344e-12	71.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,23S6Y@183963|Halobacteria	183963|Halobacteria	K	Phosphate uptake regulator	phoU1	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
CH1_k127_7198471_0	456442.Mboo_1176	1.331e-45	168.0	COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
CH1_k127_7198471_3	296587.XP_002501287.1	1.621e-06	58.0	2CZFK@1|root,2SA6C@2759|Eukaryota	2759|Eukaryota	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_32
CH1_k127_7198471_2	768670.Calni_0294	3.461e-09	68.0	COG1351@1|root,COG1351@2|Bacteria,2GF4Y@200930|Deferribacteres	200930|Deferribacteres	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
CH1_k127_7236758_0	697281.Mahau_1243	2.247e-185	599.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales	186801|Clostridia	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CH1_k127_7288587_0	945713.IALB_3156	3.002e-116	386.0	COG0826@1|root,COG0826@2|Bacteria	2|Bacteria	O	peptidase U32	prtC	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
CH1_k127_7296805_3	1178482.BJB45_03620	8.202e-07	59.0	COG4106@1|root,COG4106@2|Bacteria,1QTS9@1224|Proteobacteria,1T1FG@1236|Gammaproteobacteria,1XJEA@135619|Oceanospirillales	135619|Oceanospirillales	S	Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25
CH1_k127_7296805_0	1047013.AQSP01000144_gene810	1.528e-32	142.0	COG1032@1|root,COG1032@2|Bacteria,2NQA8@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM,adh_short
CH1_k127_7296805_2	755732.Fluta_0105	7.233e-08	62.0	COG0500@1|root,COG2226@2|Bacteria,4PM4H@976|Bacteroidetes,1IJJ7@117743|Flavobacteriia	976|Bacteroidetes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CH1_k127_7296805_1	1122921.KB898191_gene2016	3.744e-12	74.0	COG2206@1|root,COG2206@2|Bacteria,1TR95@1239|Firmicutes,4HDYK@91061|Bacilli,26RVZ@186822|Paenibacillaceae	91061|Bacilli	T	phosphohydrolase	cnpD2	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
CH1_k127_7340344_1	1321778.HMPREF1982_03832	2.457e-69	255.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,267MR@186813|unclassified Clostridiales	186801|Clostridia	O	Collagenase	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
CH1_k127_7340344_0	351160.RCIX1685	3.659e-75	259.0	COG3369@1|root,arCOG03174@2157|Archaea,2XX0Q@28890|Euryarchaeota,2NAIG@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART zinc finger, CDGSH-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
CH1_k127_7340344_2	927704.SELR_11950	5.372e-62	220.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,4H2GT@909932|Negativicutes	909932|Negativicutes	J	Metallo-beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
CH1_k127_7360030_0	1121342.AUCO01000022_gene3004	2.694e-33	138.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,36E02@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
CH1_k127_7481952_0	519441.Smon_0483	8.088e-41	166.0	COG0194@1|root,COG0194@2|Bacteria,379NK@32066|Fusobacteria	32066|Fusobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
CH1_k127_7481952_1	267377.MMP1207	4.969e-16	83.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,23R2F@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
CH1_k127_7481952_2	572546.Arcpr_0734	6.287e-11	73.0	COG2129@1|root,arCOG01145@2157|Archaea,2XXXF@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
CH1_k127_7643677_1	273068.TTE0395	3.273e-09	66.0	COG0738@1|root,COG0738@2|Bacteria,1UJ6C@1239|Firmicutes,2494T@186801|Clostridia,42J6J@68295|Thermoanaerobacterales	186801|Clostridia	G	MFS_1 like family	-	-	-	ko:K18214	-	-	-	-	ko00000,ko01504,ko02000	2.A.1.21.6	-	-	MFS_1
CH1_k127_7643677_0	268407.PWYN_05155	5.24e-18	96.0	COG0477@1|root,COG2814@2|Bacteria,1VJNJ@1239|Firmicutes,4IT1P@91061|Bacilli,26W1K@186822|Paenibacillaceae	91061|Bacilli	EGP	Sugar-tranasporters, 12 TM	sNF3	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CH1_k127_7805730_5	1209072.ALBT01000053_gene467	2.19e-38	165.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1FHR7@10|Cellvibrio	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I9,Peptidase_S8,SLH
CH1_k127_7805730_6	78898.MVEG_06806T0	1.026e-20	108.0	COG1404@1|root,KOG4266@2759|Eukaryota,38HI5@33154|Opisthokonta,3NWUG@4751|Fungi,1GRYX@112252|Fungi incertae sedis	4751|Fungi	T	Mortierella verticillata NRRL 6337	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8,fn3_5
CH1_k127_7805730_4	515635.Dtur_0638	1.478e-43	170.0	COG1163@1|root,COG1163@2|Bacteria	2|Bacteria	S	GTP binding	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
CH1_k127_7805730_1	443254.Marpi_1389	2.127e-72	253.0	COG1136@1|root,COG1136@2|Bacteria,2GCNV@200918|Thermotogae	200918|Thermotogae	P	PFAM ABC transporter	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH1_k127_7805730_3	644281.MFS40622_0516	8.427e-56	211.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,23QAJ@183939|Methanococci	183939|Methanococci	V	MacB-like periplasmic core domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CH1_k127_7805730_2	402880.MmarC5_0971	4.678e-60	223.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,23QAJ@183939|Methanococci	183939|Methanococci	V	MacB-like periplasmic core domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CH1_k127_7805730_7	402880.MmarC5_1085	2.588e-05	55.0	COG1361@1|root,arCOG02079@2157|Archaea,2XTX8@28890|Euryarchaeota,23QFC@183939|Methanococci	183939|Methanococci	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_7805730_0	130081.XP_005705890.1	2.006e-86	293.0	COG0162@1|root,KOG2144@2759|Eukaryota	2759|Eukaryota	J	tyrosine-tRNA ligase activity	YARS	GO:0000049,GO:0000166,GO:0001664,GO:0002181,GO:0002682,GO:0002685,GO:0002688,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0005102,GO:0005126,GO:0005153,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0006915,GO:0006935,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008219,GO:0009058,GO:0009059,GO:0009605,GO:0009966,GO:0009987,GO:0010467,GO:0010469,GO:0010494,GO:0010646,GO:0010758,GO:0012501,GO:0016070,GO:0016597,GO:0016604,GO:0016874,GO:0016875,GO:0017076,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0023051,GO:0030334,GO:0030545,GO:0030554,GO:0031406,GO:0031974,GO:0031981,GO:0032101,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0035770,GO:0036094,GO:0036464,GO:0040011,GO:0040012,GO:0042056,GO:0042221,GO:0042330,GO:0042379,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045236,GO:0046483,GO:0046983,GO:0048018,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050918,GO:0050920,GO:0051270,GO:0051716,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0072545,GO:0090304,GO:0097159,GO:0097367,GO:0098772,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1905521,GO:1990904,GO:2000145	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iMM904.YGR185C,iND750.YGR185C	tRNA-synt_1b,tRNA_bind
CH1_k127_7843234_1	40149.OMERI03G16020.1	1.312e-32	135.0	COG1798@1|root,KOG3123@2759|Eukaryota,37JA5@33090|Viridiplantae,3GCGV@35493|Streptophyta,3KT5H@4447|Liliopsida,3I2EA@38820|Poales	35493|Streptophyta	J	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	GO:0003674,GO:0003824,GO:0004164,GO:0006417,GO:0006448,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:2000112,GO:2000765	2.1.1.314	ko:K00586	-	-	R11165	RC00003,RC03382	ko00000,ko01000,ko03012	-	-	-	TP_methylase
CH1_k127_7843234_2	1227497.C491_06893	1.932e-25	113.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,23SEE@183963|Halobacteria	183963|Halobacteria	J	Sua5 YciO YrdC YwlC family protein	yrdC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
CH1_k127_7843234_0	644281.MFS40622_0107	5.099e-44	171.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,23QQW@183939|Methanococci	183939|Methanococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
CH1_k127_7969946_0	565033.GACE_1529	5.248e-86	295.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
CH1_k127_7969946_1	272844.PAB0749	6.806e-23	102.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,2445M@183968|Thermococci	183968|Thermococci	J	structural constituent of ribosome	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
CH1_k127_7969946_2	420247.Msm_0182	5.504e-17	82.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,23P7B@183925|Methanobacteria	183925|Methanobacteria	K	Belongs to the snRNP Sm proteins family	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
CH1_k127_797803_3	420247.Msm_1194	2.621e-11	68.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,23P3R@183925|Methanobacteria	183925|Methanobacteria	J	ribosomal protein S15	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
CH1_k127_797803_2	420247.Msm_1198	1.559e-32	134.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
CH1_k127_797803_0	572546.Arcpr_1035	2.475e-105	358.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,246QR@183980|Archaeoglobi	183980|Archaeoglobi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
CH1_k127_797803_1	589924.Ferp_0026	3.656e-82	286.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,245Z7@183980|Archaeoglobi	183980|Archaeoglobi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
CH1_k127_8005409_4	435591.BDI_1010	9.26e-07	55.0	COG4640@1|root,COG4640@2|Bacteria,4PIJG@976|Bacteroidetes,2FTJN@200643|Bacteroidia,231A8@171551|Porphyromonadaceae	976|Bacteroidetes	S	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
CH1_k127_8005409_2	593750.Metfor_1841	2.372e-14	74.0	arCOG03597@1|root,arCOG03597@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
CH1_k127_8005409_3	453591.Igni_0620	4.863e-14	83.0	COG0655@1|root,arCOG02572@2157|Archaea,2XSST@28889|Crenarchaeota	28889|Crenarchaeota	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CH1_k127_8005409_1	485913.Krac_8476	3.05e-17	86.0	COG3794@1|root,COG3794@2|Bacteria,2G7GX@200795|Chloroflexi	200795|Chloroflexi	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
CH1_k127_8005409_0	909663.KI867150_gene2365	5.413e-84	282.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2MQTD@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Ferritin-like domain	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CH1_k127_8008583_0	1291050.JAGE01000001_gene2014	7.444e-78	274.0	COG1623@1|root,COG1623@2|Bacteria,1TQD8@1239|Firmicutes,247J4@186801|Clostridia,3WNV9@541000|Ruminococcaceae	186801|Clostridia	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
CH1_k127_8092255_1	314345.SPV1_05874	3.944e-41	156.0	COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria	1224|Proteobacteria	EJ	GlutRNAGln amidotransferase subunit D	aspG	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
CH1_k127_8092255_0	521045.Kole_1753	6.171e-122	408.0	COG1032@1|root,COG1032@2|Bacteria,2GC64@200918|Thermotogae	200918|Thermotogae	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
CH1_k127_8092255_2	456320.Mvol_1582	0.0005777	48.0	COG2512@1|root,arCOG00386@2157|Archaea	2157|Archaea	S	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR,MarR_2,TrmB
CH1_k127_8159813_1	368408.Tpen_1406	5.4e-09	63.0	arCOG09752@1|root,arCOG09752@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_8159813_0	399549.Msed_1940	1.546e-14	79.0	COG0495@1|root,arCOG00809@2157|Archaea,2XPP2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
CH1_k127_8212239_1	1279015.KB908460_gene2830	1.84e-05	51.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1Y46S@135624|Aeromonadales	135624|Aeromonadales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183,ko:K11189,ko:K11201	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00306	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2
CH1_k127_8212239_0	382464.ABSI01000010_gene3393	1.248e-120	396.0	COG0019@1|root,COG0019@2|Bacteria,46SC5@74201|Verrucomicrobia,2ITWM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CH1_k127_8249066_0	404380.Gbem_2560	2.043e-72	247.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,42QWQ@68525|delta/epsilon subdivisions,2WMRI@28221|Deltaproteobacteria,43T93@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_8249066_1	484019.THA_1994	1.669e-46	171.0	COG3476@1|root,COG3476@2|Bacteria	2|Bacteria	T	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	tspO	GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
CH1_k127_8249066_2	1121935.AQXX01000117_gene5104	7.655e-41	153.0	arCOG05193@1|root,2ZZSG@2|Bacteria,1REJB@1224|Proteobacteria,1SQYC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_8344433_1	96561.Dole_1396	3.027e-62	227.0	COG0289@1|root,COG0289@2|Bacteria,1QB39@1224|Proteobacteria,42NRC@68525|delta/epsilon subdivisions,2WJGM@28221|Deltaproteobacteria,2MJ2I@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the DapB family	-	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
CH1_k127_8344433_0	555088.DealDRAFT_2793	6.692e-105	350.0	COG1712@1|root,COG1712@2|Bacteria,1TQ4R@1239|Firmicutes,2499V@186801|Clostridia	186801|Clostridia	E	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate	ddh	-	1.4.1.16	ko:K03340	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	M00526	R02755	RC00006	ko00000,ko00001,ko00002,ko01000	-	-	-	DAPDH_C,DapB_N
CH1_k127_8344433_2	583355.Caka_1808	6.028e-19	89.0	COG0019@1|root,COG0019@2|Bacteria,46SC5@74201|Verrucomicrobia,3K7IM@414999|Opitutae	414999|Opitutae	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CH1_k127_8438228_0	386456.JQKN01000002_gene2566	1.222e-79	282.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,23NWM@183925|Methanobacteria	183925|Methanobacteria	J	MiaB-like tRNA modifying enzyme, archaeal-type	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CH1_k127_8438228_1	1303518.CCALI_01379	2.547e-19	96.0	COG1413@1|root,COG2211@1|root,COG1413@2|Bacteria,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	3.4.11.2	ko:K01256,ko:K16210	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002,ko02000	2.A.2.5	-	-	HEAT_2,MFS_1
CH1_k127_8529624_0	1122165.AUHS01000007_gene958	4.257e-38	153.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1JE5S@118969|Legionellales	118969|Legionellales	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
CH1_k127_8529624_1	84531.JMTZ01000004_gene2369	0.0007921	51.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1QVQS@1224|Proteobacteria,1T2H8@1236|Gammaproteobacteria,1XD56@135614|Xanthomonadales	135614|Xanthomonadales	O	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,PPC
CH1_k127_8558460_0	579137.Metvu_0945	1.134e-196	642.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,23Q5F@183939|Methanococci	183939|Methanococci	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CH1_k127_8568723_0	573063.Metin_1388	1.392e-32	134.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,23QCE@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
CH1_k127_8616879_0	386456.JQKN01000001_gene2273	2.065e-95	321.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,23NSP@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CH1_k127_862332_0	351160.RCIX2217	1.651e-120	404.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
CH1_k127_862332_1	387631.Asulf_00247	6.796e-18	96.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,245QB@183980|Archaeoglobi	28890|Euryarchaeota	N	PFAM type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
CH1_k127_8649348_0	243232.MJ_0324	4.376e-165	531.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,23Q4E@183939|Methanococci	183939|Methanococci	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CH1_k127_8820455_0	224719.Abm4_0284	5.546e-37	150.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,23NTY@183925|Methanobacteria	183925|Methanobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
CH1_k127_8820455_1	554065.XP_005848322.1	3.542e-34	134.0	COG0162@1|root,KOG2144@2759|Eukaryota,37ICN@33090|Viridiplantae,34JRD@3041|Chlorophyta	3041|Chlorophyta	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
CH1_k127_882379_0	529709.PYCH_06750	1.184e-20	101.0	COG1378@1|root,arCOG02037@2157|Archaea,2XWE1@28890|Euryarchaeota,242PS@183968|Thermococci	183968|Thermococci	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
CH1_k127_882379_1	673860.AciM339_0722	5.1e-05	54.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,3F33H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Presenilin, signal peptide peptidase, family	-	-	-	-	-	-	-	-	-	-	-	-	SPP
CH1_k127_8931390_0	420247.Msm_0492	7.817e-61	220.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,23NSZ@183925|Methanobacteria	183925|Methanobacteria	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
CH1_k127_900667_0	224325.AF_1451	5.076e-172	552.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,246XE@183980|Archaeoglobi	183980|Archaeoglobi	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
CH1_k127_9026897_0	1355368.JART01000025_gene250	2.061e-41	156.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2YMZV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	PFAM SNARE associated Golgi protein	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CH1_k127_9055317_2	870187.Thini_3408	3.124e-07	58.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,460MT@72273|Thiotrichales	72273|Thiotrichales	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4,TMP-TENI
CH1_k127_9055317_1	1168289.AJKI01000001_gene3682	8.062e-14	73.0	2EMYX@1|root,33FM2@2|Bacteria,4NY90@976|Bacteroidetes,2FZJV@200643|Bacteroidia,3XM0C@558415|Marinilabiliaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_9055317_0	411473.RUMCAL_03485	3.099e-16	80.0	COG2314@1|root,COG2314@2|Bacteria,1VNA3@1239|Firmicutes,24RNK@186801|Clostridia	186801|Clostridia	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
CH1_k127_9055317_3	391623.TERMP_01413	6.247e-07	53.0	arCOG06386@1|root,arCOG06386@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CH1_k127_9122275_1	402880.MmarC5_0204	9.973e-40	158.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,23QZE@183939|Methanococci	183939|Methanococci	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
CH1_k127_9122275_0	1183377.Py04_1724	3.562e-54	200.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
CH1_k127_922778_0	635013.TherJR_1878	5.754e-83	281.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,25ZYB@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
CH1_k127_922778_1	1123256.KB907925_gene1044	6.014e-60	220.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1S3J8@1236|Gammaproteobacteria,1XC9E@135614|Xanthomonadales	135614|Xanthomonadales	S	Predicted membrane protein (DUF2238)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2238
CH1_k127_922778_2	273068.TTE2723	2.665e-59	216.0	COG3340@1|root,COG3340@2|Bacteria,1TRBA@1239|Firmicutes,24HZ5@186801|Clostridia	186801|Clostridia	E	Belongs to the peptidase S51 family	pepE	-	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
CH1_k127_922778_3	1048983.EL17_18150	1.218e-27	119.0	COG1670@1|root,COG1670@2|Bacteria,4NR1U@976|Bacteroidetes,47RFS@768503|Cytophagia	976|Bacteroidetes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CH1_k127_9284632_3	1121396.KB893064_gene1164	2.823e-36	148.0	COG0641@1|root,COG0641@2|Bacteria,1PZXY@1224|Proteobacteria,42RB6@68525|delta/epsilon subdivisions,2WMX1@28221|Deltaproteobacteria,2MK2Q@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S single cluster domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CH1_k127_9284632_0	272844.PAB0323	7.53e-92	320.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
CH1_k127_9284632_4	198467.NP92_13750	1.724e-23	106.0	2ARWP@1|root,31H8I@2|Bacteria,1V6GW@1239|Firmicutes,4HNAR@91061|Bacilli,21X4J@150247|Anoxybacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_9284632_1	1121403.AUCV01000024_gene3448	6.865e-77	271.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2MIGY@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
CH1_k127_9284632_2	604354.TSIB_0722	7.748e-37	158.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
CH1_k127_934793_2	1415775.U729_3154	3.798e-05	54.0	COG1467@1|root,COG1467@2|Bacteria,1VHYM@1239|Firmicutes	1239|Firmicutes	L	DNA primase activity	-	-	-	-	-	-	-	-	-	-	-	-	PriCT_1
CH1_k127_934793_1	1041930.Mtc_1177	1.398e-06	59.0	COG1468@1|root,arCOG00786@2157|Archaea,2XWES@28890|Euryarchaeota,2NBBI@224756|Methanomicrobia	224756|Methanomicrobia	V	PD-(D/E)XK nuclease superfamily	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
CH1_k127_934793_0	102232.GLO73106DRAFT_00013720	3.273e-07	61.0	COG1468@1|root,COG1518@1|root,COG1468@2|Bacteria,COG1518@2|Bacteria,1G3AP@1117|Cyanobacteria	1117|Cyanobacteria	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1,Cas_Cas4
CH1_k127_9570236_3	398512.JQKC01000032_gene4476	4.458e-09	62.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,3WPR5@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
CH1_k127_9570236_2	1042877.GQS_05645	4.57e-12	68.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,244PJ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
CH1_k127_9570236_1	1210908.HSB1_36770	3.587e-12	68.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,23XKI@183963|Halobacteria	183963|Halobacteria	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
CH1_k127_9570236_0	1042877.GQS_05625	3.964e-40	153.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,243RT@183968|Thermococci	183968|Thermococci	K	DNA-directed RNA polymerase, subunit E	rpoE1	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
CH1_k127_9579998_2	402880.MmarC5_0519	2.345e-06	56.0	arCOG02261@1|root,arCOG02261@2157|Archaea,2XWQZ@28890|Euryarchaeota,23QUF@183939|Methanococci	183939|Methanococci	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
CH1_k127_9579998_0	456320.Mvol_1366	2.009e-33	133.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,23QTK@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
CH1_k127_9579998_1	479437.Elen_3109	8.801e-10	60.0	COG0550@1|root,COG0550@2|Bacteria,2HWEV@201174|Actinobacteria,4CYBE@84998|Coriobacteriia	84998|Coriobacteriia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	-	-	-	-	-	-	-	-	-	-	-
CH1_k127_9829999_0	289377.HL41_04930	3.93e-97	325.0	COG1180@1|root,COG1180@2|Bacteria,2GH8R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
CH1_k127_9829999_2	1071085.KK033115_gene2160	2.552e-11	70.0	COG3428@1|root,arCOG04619@2157|Archaea,2XU23@28890|Euryarchaeota,23T8S@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	bPH_2
CH1_k127_9829999_1	1304885.AUEY01000072_gene1701	2.445e-35	141.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,42SBG@68525|delta/epsilon subdivisions,2WP66@28221|Deltaproteobacteria,2MK8S@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
CH1_k127_9837767_0	192952.MM_1491	8.452e-90	311.0	COG0433@1|root,arCOG00284@2157|Archaea,2Y7NC@28890|Euryarchaeota,2NBKJ@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
CH1_k127_9886848_1	1342299.Z947_2786	1.257e-05	56.0	COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2U580@28211|Alphaproteobacteria,3ZXD7@60136|Sulfitobacter	28211|Alphaproteobacteria	K	AsnC-type helix-turn-helix domain	grp	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
CH1_k127_9886848_0	298386.PBPRA3535	1.682e-06	59.0	COG1522@1|root,COG1522@2|Bacteria,1MWPX@1224|Proteobacteria,1RRPA@1236|Gammaproteobacteria,1XSDD@135623|Vibrionales	135623|Vibrionales	K	COG1522 Transcriptional regulators	asnC	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_AsnC-type
CH1_k127_9918683_0	941824.TCEL_00309	8.423e-111	369.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,36DXY@31979|Clostridiaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CH1_k127_9918683_5	457570.Nther_1788	4.009e-13	74.0	COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes,24QPY@186801|Clostridia	186801|Clostridia	D	cluster protein-associated redox disulfide domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
CH1_k127_9918683_1	457415.HMPREF1006_01497	1.024e-33	134.0	COG0822@1|root,COG0822@2|Bacteria,3TB65@508458|Synergistetes	508458|Synergistetes	C	FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
CH1_k127_9918683_3	397948.Cmaq_1928	3.722e-24	110.0	COG0081@1|root,arCOG04289@2157|Archaea,2XQ8W@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
CH1_k127_9918683_2	1236689.MMALV_00500	4.573e-30	130.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,3F2JW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s,Ribosomal_L10
CH1_k127_9918683_4	573063.Metin_1010	1.764e-20	94.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,23R5H@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
## 515 queries scanned
## Total time (seconds): 15.41387391090393
## Rate: 33.41 q/s