## Sat Dec 13 06:34:20 2025
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/qs/new/CH3_bin.37.fa -m mmseqs --itype genome -o CH3_bin.37 --output_dir /data/result/bins/wyx/egg/CH3_bin.37 --cpu 32
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CH3_k127_10001940_2	857087.Metme_2462	2.67e-58	209.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XE8Y@135618|Methylococcales	135618|Methylococcales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
CH3_k127_10001940_1	1116472.MGMO_125c00260	9.652e-110	363.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XEK0@135618|Methylococcales	135618|Methylococcales	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
CH3_k127_10001940_0	697282.Mettu_1687	5.644e-150	479.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1XDSQ@135618|Methylococcales	135618|Methylococcales	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
CH3_k127_1002066_4	697282.Mettu_2894	9.372e-50	180.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1XDK0@135618|Methylococcales	135618|Methylococcales	J	Elongation factor P--(R)-beta-lysine ligase	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
CH3_k127_1002066_0	686340.Metal_0143	0.0	1096.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1XDRZ@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CH3_k127_1002066_3	697282.Mettu_2892	2.963e-60	213.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1XF7V@135618|Methylococcales	135618|Methylococcales	M	Belongs to the skp family	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
CH3_k127_1002066_2	243233.MCA2445	1.269e-69	241.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1XEYJ@135618|Methylococcales	135618|Methylococcales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
CH3_k127_1002066_1	857087.Metme_2639	2.055e-138	443.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,1XECT@135618|Methylococcales	135618|Methylococcales	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
CH3_k127_1002066_5	998674.ATTE01000001_gene2255	3.564e-21	94.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,460NW@72273|Thiotrichales	72273|Thiotrichales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
CH3_k127_10046267_1	1116472.MGMO_63c00120	1.146e-33	132.0	COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,1RS00@1236|Gammaproteobacteria,1XG71@135618|Methylococcales	135618|Methylococcales	F	Adenylosuccinate lyase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADSL_C,Lyase_1
CH3_k127_10046267_0	1116472.MGMO_63c00100	2.309e-150	495.0	COG0165@1|root,COG0165@2|Bacteria,1MUB6@1224|Proteobacteria,1SM3E@1236|Gammaproteobacteria,1XFZ0@135618|Methylococcales	135618|Methylococcales	E	Argininosuccinate lyase C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	ASL_C2,Lyase_1
CH3_k127_10046267_2	1116472.MGMO_63c00090	1.102e-21	96.0	COG1809@1|root,COG1809@2|Bacteria,1PPRI@1224|Proteobacteria,1THYG@1236|Gammaproteobacteria,1XG1N@135618|Methylococcales	135618|Methylococcales	H	(2R)-phospho-3-sulfolactate synthase (ComA)	-	-	-	-	-	-	-	-	-	-	-	-	ComA
CH3_k127_10048204_4	857087.Metme_0663	6.077e-32	125.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XFQ2@135618|Methylococcales	135618|Methylococcales	K	SMART Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CH3_k127_10048204_3	686340.Metal_3950	6.143e-72	248.0	COG0500@1|root,COG2226@2|Bacteria,1MYPU@1224|Proteobacteria,1SZ13@1236|Gammaproteobacteria,1XE4M@135618|Methylococcales	135618|Methylococcales	H	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CH3_k127_10048204_1	1131266.ARWQ01000001_gene1238	3.393e-89	304.0	arCOG08055@1|root,arCOG08055@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CH3_k127_10048204_2	686340.Metal_3357	5.074e-85	289.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1XEWR@135618|Methylococcales	135618|Methylococcales	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
CH3_k127_10048204_0	686340.Metal_3054	3.991e-253	803.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales	135618|Methylococcales	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
CH3_k127_10054734_1	697282.Mettu_2655	3.257e-79	270.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1XEJC@135618|Methylococcales	135618|Methylococcales	M	Transfers the fatty acyl group on membrane lipoproteins	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
CH3_k127_10054734_0	472759.Nhal_1636	7.885e-127	420.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WXH8@135613|Chromatiales	135613|Chromatiales	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
CH3_k127_10056410_3	697282.Mettu_1136	5.857e-09	58.0	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1XFGK@135618|Methylococcales	135618|Methylococcales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
CH3_k127_10056410_1	697282.Mettu_1137	1.319e-126	409.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1XEDU@135618|Methylococcales	135618|Methylococcales	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CH3_k127_10056410_0	686340.Metal_1537	0.0	1040.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1XE1C@135618|Methylococcales	135618|Methylococcales	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
CH3_k127_10056410_2	857087.Metme_2789	4.098e-97	322.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XE25@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CH3_k127_10066667_0	857087.Metme_2968	0.0	1028.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XE8F@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
CH3_k127_10066667_1	1116472.MGMO_8c00070	1.533e-64	223.0	COG1063@1|root,COG1063@2|Bacteria,1QXQ8@1224|Proteobacteria,1S1AP@1236|Gammaproteobacteria,1XDQD@135618|Methylococcales	135618|Methylococcales	E	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
CH3_k127_10094135_16	857087.Metme_3300	7.536e-49	176.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1XDUN@135618|Methylococcales	135618|Methylococcales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CH3_k127_10094135_15	697282.Mettu_2604	5.845e-62	220.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1XF1X@135618|Methylococcales	135618|Methylococcales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CH3_k127_10094135_6	697282.Mettu_2603	1.587e-170	541.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1XDVC@135618|Methylococcales	135618|Methylococcales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
CH3_k127_10094135_12	697282.Mettu_0715	3.513e-95	313.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,1S2N9@1236|Gammaproteobacteria,1XEUU@135618|Methylococcales	135618|Methylococcales	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
CH3_k127_10094135_10	686340.Metal_1903	3.382e-111	366.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria,1XEAW@135618|Methylococcales	135618|Methylococcales	S	PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
CH3_k127_10094135_1	697282.Mettu_0695	4.21e-279	869.0	COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria,1XEI6@135618|Methylococcales	135618|Methylococcales	V	ABC transporter transmembrane region	-	-	-	ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC_membrane,ABC_tran
CH3_k127_10094135_5	1116472.MGMO_122c00160	3.447e-179	581.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1XEAS@135618|Methylococcales	135618|Methylococcales	M	Soluble lytic murein transglycosylase L domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
CH3_k127_10094135_11	686340.Metal_1906	7.249e-97	317.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1XDP9@135618|Methylococcales	135618|Methylococcales	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
CH3_k127_10094135_2	697282.Mettu_0698	4.488e-227	707.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XDY1@135618|Methylococcales	135618|Methylococcales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CH3_k127_10094135_8	1116472.MGMO_122c00100	4.456e-150	478.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1XER0@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
CH3_k127_10094135_13	697282.Mettu_0700	1.79e-90	305.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,1RQES@1236|Gammaproteobacteria,1XF1I@135618|Methylococcales	135618|Methylococcales	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
CH3_k127_10094135_19	1283300.ATXB01000002_gene2880	2.702e-06	50.0	2AW8E@1|root,31N3P@2|Bacteria,1QJV8@1224|Proteobacteria,1THWU@1236|Gammaproteobacteria,1XFWT@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10094135_17	697282.Mettu_1006	6.786e-31	126.0	COG2916@1|root,COG2916@2|Bacteria,1N801@1224|Proteobacteria,1SF10@1236|Gammaproteobacteria,1XFFV@135618|Methylococcales	135618|Methylococcales	S	Domain in histone-like proteins of HNS family	-	-	-	ko:K03746	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	Histone_HNS
CH3_k127_10094135_0	697282.Mettu_1004	0.0	1388.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1XETD@135618|Methylococcales	135618|Methylococcales	C	2-oxoglutarate dehydrogenase, E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
CH3_k127_10094135_7	857087.Metme_1899	2.589e-169	542.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1XE5M@135618|Methylococcales	135618|Methylococcales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CH3_k127_10094135_4	697282.Mettu_1002	1.774e-180	577.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XEGA@135618|Methylococcales	135618|Methylococcales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
CH3_k127_10094135_3	686340.Metal_0524	3.408e-217	677.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1XDQR@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CH3_k127_10094135_9	697282.Mettu_0163	1.51e-132	430.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1XEP2@135618|Methylococcales	135618|Methylococcales	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
CH3_k127_10094135_14	686340.Metal_2051	5.53e-67	230.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1XDJB@135618|Methylococcales	135618|Methylococcales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
CH3_k127_10096127_1	1116472.MGMO_89c00080	5.977e-136	439.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1XEZQ@135618|Methylococcales	135618|Methylococcales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
CH3_k127_10096127_0	1116472.MGMO_89c00090	4.535e-248	769.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1XDK2@135618|Methylococcales	135618|Methylococcales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
CH3_k127_10109811_3	582744.Msip34_0982	1.889e-65	228.0	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,2VSIM@28216|Betaproteobacteria,2KKHC@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CH3_k127_10109811_1	1198232.CYCME_2487	1.078e-174	555.0	COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,1RX07@1236|Gammaproteobacteria,45ZPJ@72273|Thiotrichales	72273|Thiotrichales	O	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
CH3_k127_10109811_2	697282.Mettu_2182	8.38e-78	267.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,1XEWA@135618|Methylococcales	135618|Methylococcales	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA
CH3_k127_10109811_0	697282.Mettu_2989	1.383e-179	574.0	COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1XDIY@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CH3_k127_10111736_2	697282.Mettu_0772	2.543e-45	166.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1XEMF@135618|Methylococcales	135618|Methylococcales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
CH3_k127_10111736_1	697282.Mettu_3791	4.374e-115	379.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1XDZ0@135618|Methylococcales	135618|Methylococcales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
CH3_k127_10111736_0	686340.Metal_2008	3.731e-170	539.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,1XE2Z@135618|Methylococcales	135618|Methylococcales	O	Peptidase, M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
CH3_k127_10119308_0	697282.Mettu_3990	0.0	1449.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1RNIF@1236|Gammaproteobacteria,1XE0G@135618|Methylococcales	135618|Methylococcales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CH3_k127_10119308_2	697282.Mettu_2498	4.397e-62	226.0	COG0845@1|root,COG0845@2|Bacteria,1R6JG@1224|Proteobacteria,1SEA3@1236|Gammaproteobacteria,1XF38@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10119308_4	697282.Mettu_2496	3.039e-53	190.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1XF9R@135618|Methylococcales	135618|Methylococcales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
CH3_k127_10119308_3	857087.Metme_1838	1.111e-53	190.0	COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1XFB3@135618|Methylococcales	135618|Methylococcales	M	Recycling of diacylglycerol produced during the turnover of membrane phospholipid	-	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
CH3_k127_10119308_1	857087.Metme_1839	8.127e-93	306.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1XDKQ@135618|Methylococcales	135618|Methylococcales	G	pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CH3_k127_10159640_2	686340.Metal_2660	7.34e-186	585.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1XE8G@135618|Methylococcales	135618|Methylococcales	C	alcohol dehydrogenase	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
CH3_k127_10159640_0	1116472.MGMO_176c00100	0.0	1209.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RQMD@1236|Gammaproteobacteria,1XGZF@135618|Methylococcales	135618|Methylococcales	G	Carbohydrate phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphorylase
CH3_k127_10159640_1	686340.Metal_0789	3.187e-263	814.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1XE67@135618|Methylococcales	135618|Methylococcales	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
CH3_k127_10198718_3	715451.ambt_10600	8.112e-31	131.0	2DV2C@1|root,33TPD@2|Bacteria,1PAUI@1224|Proteobacteria	1224|Proteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
CH3_k127_10198718_0	857087.Metme_0613	2.307e-215	681.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales	135618|Methylococcales	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF
CH3_k127_10198718_2	686340.Metal_3480	1.404e-73	254.0	COG3577@1|root,COG3577@2|Bacteria,1RAQK@1224|Proteobacteria,1S2GF@1236|Gammaproteobacteria,1XGKN@135618|Methylococcales	135618|Methylococcales	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	gag-asp_proteas
CH3_k127_10198718_1	1116472.MGMO_172c00080	9.23e-131	419.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1XE0H@135618|Methylococcales	135618|Methylococcales	L	PFAM Endonuclease Exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
CH3_k127_1019882_5	697282.Mettu_2795	3.974e-14	73.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1S30B@1236|Gammaproteobacteria,1XE5K@135618|Methylococcales	135618|Methylococcales	HJ	Belongs to the RimK family	-	-	-	-	-	-	-	-	-	-	-	-	RimK
CH3_k127_1019882_2	1116472.MGMO_92c00120	9.736e-105	348.0	COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,1S4ZR@1236|Gammaproteobacteria,1XDPE@135618|Methylococcales	135618|Methylococcales	H	ATP:dephospho-CoA triphosphoribosyl transferase	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
CH3_k127_1019882_3	697282.Mettu_2797	8.613e-90	298.0	COG1795@1|root,COG1795@2|Bacteria,1NDRY@1224|Proteobacteria,1S2AH@1236|Gammaproteobacteria,1XDXM@135618|Methylococcales	135618|Methylococcales	S	PFAM Formaldehyde-activating enzyme	-	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
CH3_k127_1019882_4	686340.Metal_3520	2.963e-63	224.0	COG1411@1|root,COG1411@2|Bacteria,1RHWE@1224|Proteobacteria,1S8KI@1236|Gammaproteobacteria,1XF7T@135618|Methylococcales	135618|Methylococcales	S	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CH3_k127_1019882_0	686340.Metal_2917	1.575e-229	715.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1XDZN@135618|Methylococcales	135618|Methylococcales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
CH3_k127_1019882_1	697282.Mettu_2977	1.609e-174	557.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1XE8R@135618|Methylococcales	135618|Methylococcales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
CH3_k127_1019882_6	1116472.MGMO_8c01140	2.675e-06	49.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1XDPP@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CH3_k127_10210990_1	697282.Mettu_3138	7.401e-71	246.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1XEJX@135618|Methylococcales	135618|Methylococcales	H	MoeA N-terminal region (domain I	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
CH3_k127_10210990_2	1116472.MGMO_53c00180	4.327e-62	218.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria,1XF57@135618|Methylococcales	135618|Methylococcales	H	molybdopterin-guanine dinucleotide biosynthesis	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
CH3_k127_10210990_3	1116472.MGMO_53c00170	5.995e-30	124.0	COG2214@1|root,COG2214@2|Bacteria,1PUS9@1224|Proteobacteria,1SER6@1236|Gammaproteobacteria,1XFCY@135618|Methylococcales	135618|Methylococcales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
CH3_k127_10210990_5	697282.Mettu_3141	3.937e-10	61.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1XFJ3@135618|Methylococcales	135618|Methylococcales	D	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CH3_k127_10210990_4	547045.NEISICOT_01234	4.805e-11	64.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,2KQY2@206351|Neisseriales	206351|Neisseriales	DM	Peptidase, M23 family	-	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
CH3_k127_10210990_0	1116472.MGMO_53c00150	1.355e-142	459.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1XEFR@135618|Methylococcales	135618|Methylococcales	K	TIGRFAM RNA polymerase sigma factor RpoS	rpoS	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CH3_k127_10235380_0	857087.Metme_3342	1.059e-300	927.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XE7K@135618|Methylococcales	135618|Methylococcales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
CH3_k127_10235380_1	1116472.MGMO_175c00110	2.105e-47	174.0	COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,1S7QD@1236|Gammaproteobacteria,1XF9C@135618|Methylococcales	135618|Methylococcales	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
CH3_k127_10246788_1	697282.Mettu_1405	1.755e-259	806.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales	135618|Methylococcales	H	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
CH3_k127_10246788_2	1116472.MGMO_85c00340	1.905e-239	750.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1XDIP@135618|Methylococcales	135618|Methylococcales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
CH3_k127_10246788_6	857087.Metme_0732	1.457e-141	461.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2206 HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
CH3_k127_10246788_0	697282.Mettu_3849	5.281e-304	947.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1XDRJ@135618|Methylococcales	135618|Methylococcales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
CH3_k127_10246788_8	697282.Mettu_3848	1.226e-130	423.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1XEE0@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CH3_k127_10246788_16	1236542.BALM01000007_gene3417	2.283e-59	213.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,2Q93P@267890|Shewanellaceae	1236|Gammaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CH3_k127_10246788_7	1116472.MGMO_126c00120	7.254e-138	445.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1XE69@135618|Methylococcales	135618|Methylococcales	OU	signal peptide peptidase SppA	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
CH3_k127_10246788_21	697282.Mettu_3845	1.689e-06	53.0	2DETF@1|root,2ZP6V@2|Bacteria,1PBEN@1224|Proteobacteria,1SU70@1236|Gammaproteobacteria,1XFPA@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10246788_9	686340.Metal_0249	6.533e-112	365.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1XDXZ@135618|Methylococcales	135618|Methylococcales	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CH3_k127_10246788_5	697282.Mettu_3843	1.782e-161	520.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,1XE88@135618|Methylococcales	135618|Methylococcales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CH3_k127_10246788_12	1283300.ATXB01000001_gene445	1.722e-84	297.0	COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,1RRD5@1236|Gammaproteobacteria,1XEQ7@135618|Methylococcales	135618|Methylococcales	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
CH3_k127_10246788_19	1234364.AMSF01000030_gene3434	6.313e-15	78.0	COG0764@1|root,COG0764@2|Bacteria,1NGGK@1224|Proteobacteria,1SJ6T@1236|Gammaproteobacteria,1X85H@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	-	-	-	-	-	-	-	-	-	-	FabA,PS-DH
CH3_k127_10246788_11	765911.Thivi_2251	3.178e-88	301.0	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,1WW87@135613|Chromatiales	135613|Chromatiales	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
CH3_k127_10246788_18	1163617.SCD_n02757	3.538e-29	121.0	COG4706@1|root,COG4706@2|Bacteria,1RIH4@1224|Proteobacteria,2VT0K@28216|Betaproteobacteria	28216|Betaproteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10246788_10	1444770.AF72_05930	2.278e-91	306.0	COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,1RMCB@1236|Gammaproteobacteria,1X4MA@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CH3_k127_10246788_13	697282.Mettu_2070	6.887e-80	269.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1XF1U@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
CH3_k127_10246788_3	697282.Mettu_2069	1.003e-175	560.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,1XDYI@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
CH3_k127_10246788_17	686340.Metal_3154	1.032e-30	121.0	COG1773@1|root,COG1773@2|Bacteria,1QJU0@1224|Proteobacteria,1THVE@1236|Gammaproteobacteria,1XFTX@135618|Methylococcales	135618|Methylococcales	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
CH3_k127_10246788_4	697282.Mettu_3759	3.891e-175	554.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,1RS5T@1236|Gammaproteobacteria,1XEQF@135618|Methylococcales	135618|Methylococcales	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CH3_k127_10246788_15	243233.MCA0042	5.239e-79	267.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,1XDU3@135618|Methylococcales	135618|Methylococcales	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
CH3_k127_10246788_14	243233.MCA0043	9.24e-80	267.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,1S3FD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Ribose 5-phosphate isomerase	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008786,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046367,GO:0071704,GO:1901575	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c46440,ic_1306.c5096	LacAB_rpiB
CH3_k127_10246788_20	1116472.MGMO_60c00430	1.319e-07	53.0	COG3115@1|root,COG3115@2|Bacteria,1PBVR@1224|Proteobacteria,1SWKQ@1236|Gammaproteobacteria,1XFD2@135618|Methylococcales	135618|Methylococcales	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	ko:K03528	-	-	-	-	ko00000,ko03036	-	-	-	ZipA_C
CH3_k127_10250754_0	857087.Metme_4529	0.0	1094.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales	135618|Methylococcales	H	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
CH3_k127_10253516_2	857087.Metme_1388	5.42e-94	314.0	COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,1RZWQ@1236|Gammaproteobacteria,1XDRV@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SLT
CH3_k127_10253516_1	686340.Metal_3569	4.69e-124	406.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1S32F@1236|Gammaproteobacteria,1XEVA@135618|Methylococcales	135618|Methylococcales	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
CH3_k127_10253516_0	686340.Metal_3570	6.746e-314	968.0	COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,1RZSE@1236|Gammaproteobacteria,1XG82@135618|Methylococcales	135618|Methylococcales	IJ	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1,Formyl_trans_C,Formyl_trans_N
CH3_k127_10253516_3	686340.Metal_3571	6.697e-19	91.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
CH3_k127_10331346_0	697282.Mettu_3869	2.096e-282	879.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1XDIX@135618|Methylococcales	135618|Methylococcales	E	PFAM Bacterial extracellular solute-binding	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
CH3_k127_10331346_1	686340.Metal_0224	3.319e-94	314.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1XFC3@135618|Methylococcales	135618|Methylococcales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
CH3_k127_10331346_2	768671.ThimaDRAFT_4251	4.982e-20	93.0	COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria,1WZIY@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
CH3_k127_10332934_2	697282.Mettu_1617	1.989e-96	325.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1XDWX@135618|Methylococcales	135618|Methylococcales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
CH3_k127_10332934_0	1283300.ATXB01000001_gene575	2.05e-238	751.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1XDJI@135618|Methylococcales	135618|Methylococcales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CH3_k127_10332934_1	1116472.MGMO_124c00080	2.844e-223	694.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1XEHS@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CH3_k127_10332934_3	1116472.MGMO_124c00070	3.14e-74	250.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1XDX9@135618|Methylococcales	135618|Methylococcales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
CH3_k127_10353532_8	857087.Metme_1014	0.0003157	46.0	2E5FX@1|root,3307M@2|Bacteria,1N8E5@1224|Proteobacteria,1SE6J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10353532_9	857087.Metme_1014	0.0007338	47.0	2E5FX@1|root,3307M@2|Bacteria,1N8E5@1224|Proteobacteria,1SE6J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10353532_6	1121447.JONL01000001_gene735	9.356e-10	60.0	2EG8N@1|root,33A0G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10353532_0	697282.Mettu_2839	9.356e-150	485.0	COG2308@1|root,COG2308@2|Bacteria,1P9A0@1224|Proteobacteria,1RYUQ@1236|Gammaproteobacteria,1XFCR@135618|Methylococcales	135618|Methylococcales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10353532_1	857087.Metme_1250	3.384e-87	300.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S3VR@1236|Gammaproteobacteria,1XDX1@135618|Methylococcales	135618|Methylococcales	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
CH3_k127_10353532_4	686340.Metal_3000	2.062e-31	126.0	COG0271@1|root,COG0271@2|Bacteria,1QCDN@1224|Proteobacteria,1THS7@1236|Gammaproteobacteria,1XFIA@135618|Methylococcales	135618|Methylococcales	T	Belongs to the BolA IbaG family	-	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
CH3_k127_10353532_3	697282.Mettu_1045	5.128e-41	153.0	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,1XFE9@135618|Methylococcales	135618|Methylococcales	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
CH3_k127_10353532_2	1283300.ATXB01000002_gene3128	8.201e-79	266.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1XF33@135618|Methylococcales	135618|Methylococcales	D	probably involved in intracellular septation	-	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
CH3_k127_10361439_7	977880.pRALTA_0020	8.038e-08	57.0	2DVP5@1|root,33WMA@2|Bacteria,1NWZN@1224|Proteobacteria,2W2NQ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10361439_6	76114.ebA2860	7.685e-11	65.0	2DVP5@1|root,33WMA@2|Bacteria,1NWZN@1224|Proteobacteria,2W2NQ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10361439_3	272123.Anacy_3528	4.087e-42	157.0	COG1943@1|root,COG1943@2|Bacteria,1G631@1117|Cyanobacteria,1HNBT@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CH3_k127_10361439_5	236097.ADG881_828	5.917e-11	63.0	COG3668@1|root,COG3668@2|Bacteria,1N8IJ@1224|Proteobacteria,1SDC1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG3668 Plasmid stabilization system protein	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
CH3_k127_10361439_4	686340.Metal_2348	6.625e-40	149.0	COG3609@1|root,COG3609@2|Bacteria,1PSZT@1224|Proteobacteria,1TGST@1236|Gammaproteobacteria,1XGJS@135618|Methylococcales	135618|Methylococcales	K	Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH	-	-	-	ko:K07746	-	-	-	-	ko00000,ko02048	-	-	-	ParD_antitoxin
CH3_k127_10361439_1	292415.Tbd_1967	1.958e-115	378.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,2VKGR@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,Y1_Tnp
CH3_k127_10361439_0	686340.Metal_1070	4.264e-149	476.0	COG0373@1|root,COG0373@2|Bacteria,1MXX5@1224|Proteobacteria,1S03H@1236|Gammaproteobacteria,1XDMW@135618|Methylococcales	135618|Methylococcales	H	PFAM Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
CH3_k127_10361439_2	1116472.MGMO_8c00070	1.476e-92	308.0	COG1063@1|root,COG1063@2|Bacteria,1QXQ8@1224|Proteobacteria,1S1AP@1236|Gammaproteobacteria,1XDQD@135618|Methylococcales	135618|Methylococcales	E	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	-	-	-	ko:K10714	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R08059	RC00202	ko00000,ko00001,ko01000	-	-	-	Mpt_N
CH3_k127_10436468_5	686340.Metal_3602	5.049e-08	54.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XDVV@135618|Methylococcales	135618|Methylococcales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_10436468_2	697282.Mettu_1609	2.09e-100	333.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1XE1S@135618|Methylococcales	135618|Methylococcales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
CH3_k127_10436468_4	686340.Metal_0513	1.628e-32	126.0	COG1734@1|root,COG1734@2|Bacteria	2|Bacteria	T	zinc ion binding	ybiI	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
CH3_k127_10436468_1	857087.Metme_2197	4.742e-267	838.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1XDT1@135618|Methylococcales	135618|Methylococcales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CH3_k127_10436468_3	697282.Mettu_2424	4.024e-35	134.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1XFM3@135618|Methylococcales	135618|Methylococcales	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
CH3_k127_10436468_0	697282.Mettu_1092	3.33e-288	906.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1XE8U@135618|Methylococcales	135618|Methylococcales	M	Penicillin-binding protein 1A	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
CH3_k127_10479377_5	686340.Metal_3067	1.765e-29	117.0	COG0724@1|root,COG0724@2|Bacteria,1NDEM@1224|Proteobacteria,1SFDX@1236|Gammaproteobacteria,1XFGC@135618|Methylococcales	135618|Methylococcales	S	PFAM RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CH3_k127_10479377_1	1116472.MGMO_53c01010	1.398e-161	515.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,1S0IS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Fatty acid desaturase	-	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
CH3_k127_10479377_4	686340.Metal_1082	1.171e-91	305.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,1S4C3@1236|Gammaproteobacteria,1XEGY@135618|Methylococcales	135618|Methylococcales	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CH3_k127_10479377_2	1283300.ATXB01000001_gene792	1.731e-151	492.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Membrane-bound serine protease (ClpP class)	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
CH3_k127_10479377_3	1123517.JOMR01000001_gene846	9.019e-109	358.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,4600Q@72273|Thiotrichales	72273|Thiotrichales	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CH3_k127_10479377_0	1116472.MGMO_17c00180	4.143e-198	621.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1XDY0@135618|Methylococcales	135618|Methylococcales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CH3_k127_10497627_1	697282.Mettu_1765	3.228e-137	442.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1S54V@1236|Gammaproteobacteria,1XEHH@135618|Methylococcales	135618|Methylococcales	K	HTH transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CH3_k127_10497627_6	857087.Metme_4580	2.593e-54	203.0	COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,1S6PD@1236|Gammaproteobacteria,1XFCI@135618|Methylococcales	135618|Methylococcales	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,TehB
CH3_k127_10497627_5	686340.Metal_1910	2.149e-56	199.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria,1XFAM@135618|Methylococcales	135618|Methylococcales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CH3_k127_10497627_0	686340.Metal_1841	0.0	1049.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1XEI7@135618|Methylococcales	135618|Methylococcales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
CH3_k127_10497627_3	1230476.C207_02861	4.924e-77	274.0	COG2114@1|root,COG2114@2|Bacteria,1QWNC@1224|Proteobacteria,2TRQB@28211|Alphaproteobacteria,3JQN6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,Guanylate_cyc,HAMP
CH3_k127_10497627_2	1288494.EBAPG3_19700	1.001e-98	334.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,372VF@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM FAD dependent oxidoreductase	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
CH3_k127_10497627_4	323261.Noc_0059	3.545e-65	230.0	COG0863@1|root,COG1743@1|root,COG0863@2|Bacteria,COG1743@2|Bacteria,1P7I6@1224|Proteobacteria,1RMB6@1236|Gammaproteobacteria,1WXFZ@135613|Chromatiales	135613|Chromatiales	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
CH3_k127_10497627_7	1121405.dsmv_1776	4.453e-33	137.0	COG1474@1|root,COG1474@2|Bacteria,1R5I2@1224|Proteobacteria,42YAY@68525|delta/epsilon subdivisions,2WU0B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	LO	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10497627_9	1121405.dsmv_1773	2.976e-11	66.0	COG2105@1|root,COG2105@2|Bacteria,1R92V@1224|Proteobacteria,42QI0@68525|delta/epsilon subdivisions,2WKGE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AIG2 family	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
CH3_k127_10497627_8	857087.Metme_2649	3.82e-13	72.0	COG2885@1|root,COG2982@1|root,COG2885@2|Bacteria,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XE60@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
CH3_k127_10513884_0	261292.Nit79A3_1360	0.0	1359.0	COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2WEJA@28216|Betaproteobacteria,374P7@32003|Nitrosomonadales	28216|Betaproteobacteria	EO	pdz dhr glgf	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M1,Peptidase_M28
CH3_k127_10513884_1	153948.NAL212_2061	1.176e-13	73.0	COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria,2WAZU@28216|Betaproteobacteria,371UN@32003|Nitrosomonadales	28216|Betaproteobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
CH3_k127_10518414_2	697282.Mettu_2206	1.882e-31	126.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,1RNZK@1236|Gammaproteobacteria,1XES7@135618|Methylococcales	135618|Methylococcales	P	ABC transporter permease protein	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
CH3_k127_10518414_0	1007105.PT7_1069	5.101e-104	346.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,3T2NW@506|Alcaligenaceae	28216|Betaproteobacteria	P	sulfate transport system, permease	cysT	-	-	ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5	-	-	BPD_transp_1
CH3_k127_10518414_1	1242969.ATCC51562_1201	2.81e-77	269.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,42M5H@68525|delta/epsilon subdivisions,2YTMF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
CH3_k127_10535276_0	697282.Mettu_3841	0.0	1016.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1XEIC@135618|Methylococcales	135618|Methylococcales	IQ	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Acyltransferase
CH3_k127_10535276_1	697282.Mettu_3840	1.596e-164	526.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,1T1PC@1236|Gammaproteobacteria,1XERZ@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08227	-	-	-	-	ko00000,ko02000	2.A.1.42	-	-	MFS_1
CH3_k127_10545776_1	1123392.AQWL01000010_gene2299	9.83e-163	518.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,1KS7Y@119069|Hydrogenophilales	119069|Hydrogenophilales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
CH3_k127_10545776_3	1116472.MGMO_9c00220	2.123e-123	407.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1XDXV@135618|Methylococcales	135618|Methylococcales	H	Glycine cleavage system T protein	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
CH3_k127_10545776_0	697282.Mettu_3696	0.0	1497.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1XEFG@135618|Methylococcales	135618|Methylococcales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
CH3_k127_10545776_2	697282.Mettu_1439	2.157e-149	479.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1XE92@135618|Methylococcales	135618|Methylococcales	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
CH3_k127_10553256_2	857087.Metme_3718	1.162e-31	128.0	COG2010@1|root,COG2010@2|Bacteria,1P89P@1224|Proteobacteria,1STPI@1236|Gammaproteobacteria,1XFEX@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10553256_3	697282.Mettu_0347	1.79e-25	106.0	2DNYP@1|root,32ZTI@2|Bacteria,1N747@1224|Proteobacteria,1SCCQ@1236|Gammaproteobacteria,1XFTW@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
CH3_k127_10553256_1	1116472.MGMO_52c00080	1.001e-50	188.0	2AW1M@1|root,31MW7@2|Bacteria,1QJNA@1224|Proteobacteria,1THP1@1236|Gammaproteobacteria,1XF4N@135618|Methylococcales	135618|Methylococcales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
CH3_k127_10553256_0	1116472.MGMO_137c00030	7.077e-214	667.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1XDV5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CH3_k127_10576614_2	686340.Metal_2918	1.633e-44	162.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1XE8R@135618|Methylococcales	135618|Methylococcales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
CH3_k127_10576614_0	697282.Mettu_2978	4.823e-110	362.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1XDPP@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CH3_k127_10576614_1	697282.Mettu_2979	1.62e-61	216.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1XDNN@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
CH3_k127_10595576_1	1283300.ATXB01000002_gene2539	1.553e-165	541.0	COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,1RRH5@1236|Gammaproteobacteria,1XE6U@135618|Methylococcales	135618|Methylococcales	S	Phage terminase large subunit (GpA)	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_GpA
CH3_k127_10595576_3	765910.MARPU_09560	1.602e-37	148.0	2E13U@1|root,32WJ6@2|Bacteria,1NFFY@1224|Proteobacteria,1SIE5@1236|Gammaproteobacteria,1X1KW@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10595576_2	765910.MARPU_09555	3.31e-110	372.0	COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,1RRK4@1236|Gammaproteobacteria,1X0DB@135613|Chromatiales	135613|Chromatiales	S	Phage portal protein, lambda family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal_2
CH3_k127_10595576_0	765910.MARPU_09550	2.21e-180	583.0	COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,1S4MJ@1236|Gammaproteobacteria,1X0RU@135613|Chromatiales	135613|Chromatiales	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S78,Phage_capsid
CH3_k127_10596974_1	203275.BFO_1382	2.529e-27	119.0	COG3385@1|root,COG3385@2|Bacteria,4NXT2@976|Bacteroidetes,2FRVS@200643|Bacteroidia,2319R@171551|Porphyromonadaceae	976|Bacteroidetes	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
CH3_k127_10596974_0	857087.Metme_3140	5.262e-96	320.0	COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,1RS1G@1236|Gammaproteobacteria,1XEMQ@135618|Methylococcales	135618|Methylococcales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CH3_k127_1060006_3	666681.M301_1543	5.576e-22	97.0	COG1548@1|root,COG1548@2|Bacteria,1RAMA@1224|Proteobacteria,2VKAE@28216|Betaproteobacteria,2KKXS@206350|Nitrosomonadales	206350|Nitrosomonadales	GK	H4MPT-linked C1 transfer pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	Hydantoinase_A
CH3_k127_1060006_0	1116472.MGMO_92c00150	5.771e-69	246.0	COG1821@1|root,COG1821@2|Bacteria,1RBY6@1224|Proteobacteria,1SIJ0@1236|Gammaproteobacteria,1XEZB@135618|Methylococcales	135618|Methylococcales	S	PFAM ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
CH3_k127_1060006_2	323261.Noc_1299	1.324e-52	192.0	COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,1S9FV@1236|Gammaproteobacteria,1WYWP@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0225 family	-	-	-	ko:K09858	-	-	-	-	ko00000	-	-	-	SEC-C
CH3_k127_1060006_1	1174528.JH992898_gene775	5.877e-56	202.0	COG0242@1|root,COG0242@2|Bacteria,1G52N@1117|Cyanobacteria,1JHUE@1189|Stigonemataceae	1117|Cyanobacteria	J	Polypeptide deformylase	-	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CH3_k127_10604226_0	697282.Mettu_3850	1.264e-275	858.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1XEKH@135618|Methylococcales	135618|Methylococcales	L	Bacterial DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
CH3_k127_10604226_1	561229.Dd1591_3151	1.7e-65	229.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,2JE0R@204037|Dickeya	1236|Gammaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
CH3_k127_10615767_0	697282.Mettu_3920	0.0	1052.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1XDN9@135618|Methylococcales	135618|Methylococcales	I	Domain of unknown function (DUF1974)	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974
CH3_k127_10615767_1	857087.Metme_2950	2.141e-216	680.0	COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1XE91@135618|Methylococcales	135618|Methylococcales	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10615767_2	857087.Metme_1544	3.47e-152	487.0	COG2988@1|root,COG2988@2|Bacteria	2|Bacteria	E	succinylglutamate desuccinylase activity	astE	-	3.5.1.96	ko:K05526	ko00330,ko01100,map00330,map01100	-	R00411	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	AstE_AspA
CH3_k127_10615767_3	697282.Mettu_0693	3.403e-74	253.0	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,1S5XU@1236|Gammaproteobacteria,1XFDZ@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0260 family	-	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CH3_k127_10615767_4	406327.Mevan_0406	2.914e-28	121.0	COG0500@1|root,arCOG01789@2157|Archaea,2Y7UC@28890|Euryarchaeota	28890|Euryarchaeota	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10621162_1	857087.Metme_1535	4.793e-107	352.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1XE1X@135618|Methylococcales	135618|Methylococcales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
CH3_k127_10621162_0	697282.Mettu_1397	1.093e-149	482.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1XE3C@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
CH3_k127_10647410_1	857087.Metme_2141	5.534e-153	488.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1XEID@135618|Methylococcales	135618|Methylococcales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CH3_k127_10647410_2	1198232.CYCME_1534	1.417e-137	440.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,46099@72273|Thiotrichales	72273|Thiotrichales	C	Succinate dehydrogenase fumarate reductase	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17
CH3_k127_10647410_4	857087.Metme_2143	7.631e-16	80.0	COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria,1XFWP@135618|Methylococcales	135618|Methylococcales	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
CH3_k127_10647410_3	697282.Mettu_0641	1.402e-50	181.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1XFEC@135618|Methylococcales	135618|Methylococcales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
CH3_k127_10647410_0	243233.MCA1789	0.0	1065.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1XEC1@135618|Methylococcales	135618|Methylococcales	O	ATP-dependent Clp protease, ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CH3_k127_10647434_3	697282.Mettu_2877	6.361e-170	537.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1XDUT@135618|Methylococcales	135618|Methylococcales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
CH3_k127_10647434_12	686340.Metal_3787	1.236e-40	151.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1XFHG@135618|Methylococcales	135618|Methylococcales	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CH3_k127_10647434_4	686340.Metal_3788	1.486e-160	513.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,1RNEN@1236|Gammaproteobacteria,1XDZH@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CH3_k127_10647434_7	697282.Mettu_2880	1.126e-95	319.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1XE2X@135618|Methylococcales	135618|Methylococcales	M	(Lipo)protein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
CH3_k127_10647434_6	697282.Mettu_2881	3.062e-100	331.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1XE01@135618|Methylococcales	135618|Methylococcales	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	-	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
CH3_k127_10647434_11	697282.Mettu_2882	7.748e-48	174.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1XFF2@135618|Methylococcales	135618|Methylococcales	C	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
CH3_k127_10647434_2	697282.Mettu_0782	1.143e-179	573.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1XECU@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CH3_k127_10647434_5	697282.Mettu_0783	4.083e-149	476.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1XE28@135618|Methylococcales	135618|Methylococcales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CH3_k127_10647434_10	857087.Metme_2558	4.383e-58	211.0	COG2433@1|root,COG2433@2|Bacteria,1QWB7@1224|Proteobacteria,1T3FV@1236|Gammaproteobacteria,1XF8E@135618|Methylococcales	135618|Methylococcales	S	Bacterial SH3 domain homologues	-	-	-	ko:K07184	-	-	-	-	ko00000	-	-	-	SH3_3
CH3_k127_10647434_0	1116472.MGMO_111c00270	2.085e-318	981.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1XESA@135618|Methylococcales	135618|Methylococcales	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
CH3_k127_10647434_13	697282.Mettu_2447	4.594e-13	71.0	COG1598@1|root,COG1598@2|Bacteria,1NMQ9@1224|Proteobacteria,1SJ5A@1236|Gammaproteobacteria,1XFVK@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family (UPF0150)	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10647434_1	697282.Mettu_0789	2.469e-189	600.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1XEGB@135618|Methylococcales	135618|Methylococcales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
CH3_k127_10647434_8	686340.Metal_1487	2.153e-76	264.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1XEYQ@135618|Methylococcales	135618|Methylococcales	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
CH3_k127_10647434_9	697282.Mettu_0845	3.882e-60	210.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1XENV@135618|Methylococcales	135618|Methylococcales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
CH3_k127_10649480_1	697282.Mettu_4087	4.313e-187	589.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1XE0Z@135618|Methylococcales	135618|Methylococcales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
CH3_k127_10649480_3	857087.Metme_3874	2.271e-36	143.0	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1XFIV@135618|Methylococcales	135618|Methylococcales	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
CH3_k127_10649480_0	697282.Mettu_4085	0.0	1358.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1XEFT@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CH3_k127_10649480_2	697282.Mettu_4081	1.404e-142	455.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1XEFA@135618|Methylococcales	135618|Methylococcales	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
CH3_k127_10662739_7	857087.Metme_3261	2.584e-28	116.0	COG1538@1|root,COG1538@2|Bacteria,1MXB2@1224|Proteobacteria,1RSHB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MU	Outer membrane component of multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CH3_k127_10662739_2	243233.MCA1633	4.02e-152	497.0	COG3853@1|root,COG3853@2|Bacteria,1MY18@1224|Proteobacteria,1RZ1H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Toxic anion resistance family protein	-	-	-	-	-	-	-	-	-	-	-	-	TelA
CH3_k127_10662739_8	1121875.KB907549_gene1898	2.183e-07	63.0	COG1983@1|root,COG5373@1|root,COG1983@2|Bacteria,COG5373@2|Bacteria,4NGKV@976|Bacteroidetes,1HZB4@117743|Flavobacteriia	976|Bacteroidetes	KT	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
CH3_k127_10662739_6	243233.MCA1631	8.443e-60	223.0	2BDZ4@1|root,338ZA@2|Bacteria,1NNMH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10662739_9	1121448.DGI_3282	8.166e-06	53.0	COG0818@1|root,COG0818@2|Bacteria,1N67A@1224|Proteobacteria,42WBB@68525|delta/epsilon subdivisions,2WTBU@28221|Deltaproteobacteria,2MCFE@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Prokaryotic diacylglycerol kinase	-	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
CH3_k127_10662739_1	857087.Metme_0760	6.557e-263	813.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XEFM@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CH3_k127_10662739_10	1158292.JPOE01000002_gene2614	2.578e-05	47.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,1KK5J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
CH3_k127_10662739_4	1163617.SCD_n02489	1.327e-117	394.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CH3_k127_10662739_5	243159.AFE_1675	2.16e-70	245.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
CH3_k127_10662739_0	857087.Metme_0519	7.723e-306	942.0	COG2895@1|root,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,1RME4@1236|Gammaproteobacteria,1XDTV@135618|Methylococcales	135618|Methylococcales	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_EFTU
CH3_k127_10662739_3	686340.Metal_1802	1.416e-143	456.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,1RNAD@1236|Gammaproteobacteria,1XECQ@135618|Methylococcales	135618|Methylococcales	H	Sulfate adenylyltransferase subunit 2	cysD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004779,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
CH3_k127_10665370_1	697282.Mettu_3446	3.639e-65	225.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1XEK9@135618|Methylococcales	135618|Methylococcales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
CH3_k127_10665370_0	1116472.MGMO_21c00230	0.0	1068.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1XG1Q@135618|Methylococcales	135618|Methylococcales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
CH3_k127_10665370_2	697282.Mettu_3449	1.454e-38	150.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria,1XGAM@135618|Methylococcales	135618|Methylococcales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
CH3_k127_10665989_3	697282.Mettu_0117	7.359e-44	164.0	COG3217@1|root,COG3217@2|Bacteria,1MXN2@1224|Proteobacteria,1RMN7@1236|Gammaproteobacteria,1XEKB@135618|Methylococcales	135618|Methylococcales	S	MOSC N-terminal beta barrel domain	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
CH3_k127_10665989_2	686340.Metal_1876	2.626e-77	263.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1XDIN@135618|Methylococcales	135618|Methylococcales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
CH3_k127_10665989_0	697282.Mettu_4364	4.388e-218	683.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1XDQP@135618|Methylococcales	135618|Methylococcales	L	ATPase, AAA	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
CH3_k127_10665989_1	697282.Mettu_2726	1.119e-161	513.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1XE5H@135618|Methylococcales	135618|Methylococcales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
CH3_k127_10727322_0	335543.Sfum_1457	1.134e-208	653.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MR4N@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Protein export membrane protein	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
CH3_k127_10727322_2	880072.Desac_2384	1.866e-116	387.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CH3_k127_10727322_1	243233.MCA0120	2.014e-150	484.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CH3_k127_1072897_7	1265503.KB905160_gene2975	2.374e-111	368.0	COG4313@1|root,COG4313@2|Bacteria,1PC95@1224|Proteobacteria,1RZJZ@1236|Gammaproteobacteria,2Q8AT@267889|Colwelliaceae	1236|Gammaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
CH3_k127_1072897_10	525897.Dbac_1083	1.422e-67	238.0	COG5361@1|root,COG5361@2|Bacteria,1NZZJ@1224|Proteobacteria,42WCT@68525|delta/epsilon subdivisions,2WRX3@28221|Deltaproteobacteria,2MEBR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
CH3_k127_1072897_15	1123242.JH636434_gene5326	1.964e-17	82.0	COG5361@1|root,COG5361@2|Bacteria,2IY8Y@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
CH3_k127_1072897_0	768671.ThimaDRAFT_0859	0.0	1356.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1WWMT@135613|Chromatiales	135613|Chromatiales	P	PFAM Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CH3_k127_1072897_11	644968.DFW101_2930	4.058e-65	242.0	29D6U@1|root,3004T@2|Bacteria,1R9I1@1224|Proteobacteria,42T9I@68525|delta/epsilon subdivisions,2WPXB@28221|Deltaproteobacteria,2MADE@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1072897_9	1267533.KB906733_gene2856	5.661e-84	292.0	28M5B@1|root,2ZAJ4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1072897_2	1267533.KB906733_gene2861	1.599e-184	589.0	COG4320@1|root,COG4320@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
CH3_k127_1072897_6	29581.BW37_00345	1.475e-128	432.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,2WGKB@28216|Betaproteobacteria,476H4@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CH3_k127_1072897_18	1046627.BZARG_1239	4.934e-09	63.0	COG3187@1|root,COG3187@2|Bacteria,4NHC4@976|Bacteroidetes,1II5P@117743|Flavobacteriia	976|Bacteroidetes	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
CH3_k127_1072897_13	522306.CAP2UW1_2595	1.242e-34	136.0	COG3015@1|root,COG3126@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3126@2|Bacteria,COG3187@2|Bacteria,1N8AF@1224|Proteobacteria,2VXB0@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Type III secretion system lipoprotein chaperone (YscW)	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	MliC,YscW
CH3_k127_1072897_14	522306.CAP2UW1_2595	2.109e-21	96.0	COG3015@1|root,COG3126@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3126@2|Bacteria,COG3187@2|Bacteria,1N8AF@1224|Proteobacteria,2VXB0@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Type III secretion system lipoprotein chaperone (YscW)	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	MliC,YscW
CH3_k127_1072897_19	1229204.AMYY01000007_gene1237	8.334e-07	55.0	COG3126@1|root,COG3126@2|Bacteria,1N8AF@1224|Proteobacteria,2UGPH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Protein conserved in bacteria	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	META,YscW
CH3_k127_1072897_17	715451.ambt_17675	8.473e-11	64.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1R97Q@1224|Proteobacteria,1RRDP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
CH3_k127_1072897_3	391165.GbCGDNIH1_0120	6.51e-177	573.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2TRWD@28211|Alphaproteobacteria,2JPPU@204441|Rhodospirillales	204441|Rhodospirillales	M	Surface antigen	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA
CH3_k127_1072897_1	391165.GbCGDNIH1_0121	3.748e-304	977.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,2JQWJ@204441|Rhodospirillales	204441|Rhodospirillales	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
CH3_k127_1072897_8	243233.MCA0343	5.238e-101	334.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1XE9Z@135618|Methylococcales	135618|Methylococcales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
CH3_k127_1072897_16	686340.Metal_2562	4.617e-13	76.0	2AW8C@1|root,31N3M@2|Bacteria,1QJV5@1224|Proteobacteria,1THWR@1236|Gammaproteobacteria,1XFWB@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1072897_12	857087.Metme_2002	1.474e-55	201.0	COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria,1RS8P@1236|Gammaproteobacteria,1XGG0@135618|Methylococcales	135618|Methylococcales	O	Thioredoxin	-	-	-	ko:K07396	-	-	-	-	ko00000	-	-	-	Thioredoxin_5
CH3_k127_1072897_4	697282.Mettu_4361	5.628e-140	451.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1XEDZ@135618|Methylococcales	135618|Methylococcales	C	alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
CH3_k127_1072897_5	686340.Metal_3902	4.863e-134	430.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,1T1N6@1236|Gammaproteobacteria,1XEN9@135618|Methylococcales	135618|Methylococcales	C	PFAM Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CH3_k127_10748803_0	1121921.KB898706_gene2431	4.361e-119	404.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CH3_k127_10748803_1	335543.Sfum_2052	3.831e-79	268.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,42MHN@68525|delta/epsilon subdivisions,2WJU0@28221|Deltaproteobacteria,2MQNQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
CH3_k127_10768012_1	697282.Mettu_2079	2.076e-96	319.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,1RMFX@1236|Gammaproteobacteria,1XDXJ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	-	-	-	-	-	-	-	-	-	-	GTP_cyclohydro2
CH3_k127_10768012_2	1049564.TevJSym_aa01140	4.271e-48	179.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,1S2AY@1236|Gammaproteobacteria,1J762@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Phosphoglycerate mutase family	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
CH3_k127_10768012_0	697282.Mettu_2451	7.191e-286	882.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1XDU2@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
CH3_k127_10768012_3	1116472.MGMO_8c00510	1.587e-42	159.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,1XEIQ@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
CH3_k127_10771047_0	686340.Metal_2868	1.089e-113	374.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1XEBW@135618|Methylococcales	135618|Methylococcales	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
CH3_k127_10771047_1	857087.Metme_3405	3.106e-24	103.0	COG0666@1|root,COG0666@2|Bacteria,1Q6E0@1224|Proteobacteria,1TGU6@1236|Gammaproteobacteria,1XGPN@135618|Methylococcales	135618|Methylococcales	S	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10771047_3	686340.Metal_2870	2.331e-19	89.0	2B7RT@1|root,320Y1@2|Bacteria,1QK8A@1224|Proteobacteria,1TIBR@1236|Gammaproteobacteria,1XGXE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10771047_4	596154.Alide2_1786	1.434e-05	48.0	COG1061@1|root,COG1061@2|Bacteria,1MX92@1224|Proteobacteria,2VM99@28216|Betaproteobacteria,4ADAJ@80864|Comamonadaceae	28216|Betaproteobacteria	KL	PFAM Restriction endonuclease, type I, R subunit Type III, Res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
CH3_k127_10771047_2	388051.AUFE01000011_gene5315	4.361e-21	93.0	COG1061@1|root,COG1061@2|Bacteria,1MX92@1224|Proteobacteria,2VM99@28216|Betaproteobacteria,1K05X@119060|Burkholderiaceae	28216|Betaproteobacteria	KL	Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
CH3_k127_1084437_6	517418.Ctha_0072	3.946e-19	87.0	COG1881@1|root,COG1881@2|Bacteria,1FE9V@1090|Chlorobi	1090|Chlorobi	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
CH3_k127_1084437_5	686340.Metal_1850	1.445e-27	125.0	COG4783@1|root,COG4783@2|Bacteria,1QXK9@1224|Proteobacteria,1T3M0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
CH3_k127_1084437_3	1121937.AUHJ01000019_gene1316	3.733e-66	229.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,466WC@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CH3_k127_1084437_2	857087.Metme_3167	4.335e-86	290.0	COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,1S5RT@1236|Gammaproteobacteria,1XFNH@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
CH3_k127_1084437_0	857087.Metme_1092	3.865e-174	559.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales	135618|Methylococcales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CH3_k127_1084437_1	1116472.MGMO_71c00010	4.945e-89	305.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R9SN@1224|Proteobacteria,1S967@1236|Gammaproteobacteria,1XFK2@135618|Methylococcales	135618|Methylococcales	K	helix_turn_helix, mercury resistance	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
CH3_k127_1084437_7	1283300.ATXB01000001_gene1210	2.762e-12	72.0	2AW6E@1|root,31N1F@2|Bacteria,1QJT8@1224|Proteobacteria,1THUH@1236|Gammaproteobacteria,1XFRN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1084437_4	697282.Mettu_3204	2.064e-30	123.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XE3D@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CH3_k127_1086277_2	525897.Dbac_1576	2.575e-20	94.0	28HAW@1|root,2Z7N4@2|Bacteria,1R5JH@1224|Proteobacteria,42NHT@68525|delta/epsilon subdivisions,2WJXB@28221|Deltaproteobacteria,2MEDD@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	KilA-N	-	-	-	-	-	-	-	-	-	-	-	-	KilA-N
CH3_k127_1086277_0	477974.Daud_0417	1.181e-51	196.0	COG2199@1|root,COG2206@1|root,COG3322@1|root,COG5002@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,COG3322@2|Bacteria,COG5002@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia,267B5@186807|Peptococcaceae	186801|Clostridia	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9
CH3_k127_1086277_1	29581.BW37_02327	2.552e-35	139.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472RR@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PFAM EAL domain, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg
CH3_k127_10865962_1	1116472.MGMO_133c00060	1.547e-148	482.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1XEMJ@135618|Methylococcales	135618|Methylococcales	M	transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
CH3_k127_10865962_0	697282.Mettu_2188	1.337e-284	890.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1XDRC@135618|Methylococcales	135618|Methylococcales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
CH3_k127_10865962_2	1121406.JAEX01000008_gene2141	3.656e-53	192.0	COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2WPQC@28221|Deltaproteobacteria,2MBCJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	EJ	PFAM Asparaginase	aspG	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
CH3_k127_10865962_3	349521.HCH_03699	3.167e-39	151.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1XHJ1@135619|Oceanospirillales	135619|Oceanospirillales	P	antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CH3_k127_10865962_4	1500281.JQKZ01000002_gene1573	1.49e-13	72.0	COG2020@1|root,COG2020@2|Bacteria,4NJCI@976|Bacteroidetes,1I1CA@117743|Flavobacteriia,3ZSUE@59732|Chryseobacterium	976|Bacteroidetes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CH3_k127_10877262_1	243233.MCA0769	0.0	1624.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales	135618|Methylococcales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
CH3_k127_10877262_3	243233.MCA0770	2.866e-291	901.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1XE4Y@135618|Methylococcales	1236|Gammaproteobacteria	C	Glutamate synthase, NADH NADPH, small subunit	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4,Fer4_20,NAD_binding_1,Pyr_redox_2
CH3_k127_10877262_5	1283300.ATXB01000001_gene265	6.602e-27	113.0	2C4KB@1|root,32YM4@2|Bacteria,1N74A@1224|Proteobacteria,1SF3Z@1236|Gammaproteobacteria,1XFV1@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10877262_4	857087.Metme_0825	1.885e-93	322.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2206 HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
CH3_k127_10877262_2	686340.Metal_0751	1.056e-291	916.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1XE75@135618|Methylococcales	135618|Methylococcales	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
CH3_k127_10877262_0	697282.Mettu_1061	0.0	2258.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales	135618|Methylococcales	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
CH3_k127_10885412_3	697282.Mettu_3246	4.153e-17	81.0	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,1S8HH@1236|Gammaproteobacteria,1XF8H@135618|Methylococcales	135618|Methylococcales	K	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
CH3_k127_10885412_1	697282.Mettu_3247	2.294e-68	235.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,1S7GD@1236|Gammaproteobacteria,1XF5A@135618|Methylococcales	135618|Methylococcales	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
CH3_k127_10885412_0	686340.Metal_2273	5.166e-202	636.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RSKA@1236|Gammaproteobacteria,1XDQ6@135618|Methylococcales	135618|Methylococcales	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
CH3_k127_10885412_2	686340.Metal_2143	1.048e-30	124.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XE3D@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CH3_k127_10920372_6	1116472.MGMO_97c00090	1.574e-54	195.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1XE8I@135618|Methylococcales	135618|Methylococcales	H	TIGRFAM Coenzyme PQQ biosynthesis protein E	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CH3_k127_10920372_9	1116472.MGMO_97c00100	6.565e-37	141.0	2E4CK@1|root,32Z81@2|Bacteria,1N7JR@1224|Proteobacteria,1SCEZ@1236|Gammaproteobacteria,1XFGZ@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM coenzyme PQQ biosynthesis protein PqqD	pqqD	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06138	-	-	-	-	ko00000	-	-	-	PqqD
CH3_k127_10920372_10	765911.Thivi_0433	4.275e-25	108.0	COG4636@1|root,COG4636@2|Bacteria,1RGFN@1224|Proteobacteria,1S4C8@1236|Gammaproteobacteria,1WYH3@135613|Chromatiales	135613|Chromatiales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CH3_k127_10920372_2	686340.Metal_3577	6.032e-145	462.0	COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,1RP1V@1236|Gammaproteobacteria,1XED1@135618|Methylococcales	135618|Methylococcales	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
CH3_k127_10920372_1	686340.Metal_3578	2.491e-167	529.0	COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,1RMM9@1236|Gammaproteobacteria,1XESM@135618|Methylococcales	135618|Methylococcales	S	May be involved in the transport of PQQ or its precursor to the periplasm	pqqB	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06136	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
CH3_k127_10920372_11	1116472.MGMO_97c00200	1.974e-08	58.0	2AUTR@1|root,31KGT@2|Bacteria,1QIBZ@1224|Proteobacteria,1TG68@1236|Gammaproteobacteria,1XFSA@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10920372_4	697282.Mettu_3227	1.039e-113	372.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1XDNG@135618|Methylococcales	135618|Methylococcales	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
CH3_k127_10920372_8	1116472.MGMO_97c00220	8.045e-45	164.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1XFAE@135618|Methylococcales	135618|Methylococcales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CH3_k127_10920372_0	1116472.MGMO_97c00230	8.927e-297	916.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1XER9@135618|Methylococcales	135618|Methylococcales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CH3_k127_10920372_5	697282.Mettu_1760	6.014e-62	217.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1XF3A@135618|Methylococcales	135618|Methylococcales	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
CH3_k127_10920372_3	857087.Metme_4443	7.883e-136	437.0	COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1XEB4@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
CH3_k127_10920372_7	697282.Mettu_1762	3.175e-48	184.0	COG1711@1|root,COG1711@2|Bacteria,1RIA0@1224|Proteobacteria,1S715@1236|Gammaproteobacteria,1XF8A@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3014)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3014
CH3_k127_10927222_1	697282.Mettu_2829	1.21e-164	520.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1XDQF@135618|Methylococcales	135618|Methylococcales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
CH3_k127_10927222_3	686340.Metal_0455	2.788e-43	164.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1XFCN@135618|Methylococcales	135618|Methylococcales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CH3_k127_10927222_0	1283300.ATXB01000001_gene1875	7.928e-249	786.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1XF30@135618|Methylococcales	135618|Methylococcales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
CH3_k127_10927222_4	686340.Metal_2568	1.281e-37	149.0	COG2197@1|root,COG2197@2|Bacteria,1N8MU@1224|Proteobacteria,1RX1I@1236|Gammaproteobacteria,1XGGG@135618|Methylococcales	135618|Methylococcales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CH3_k127_10927222_2	686340.Metal_2567	4.79e-160	512.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,1XGIM@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM type I secretion membrane fusion protein, HlyD	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
CH3_k127_10932120_4	243233.MCA1701	5.478e-159	514.0	COG2067@1|root,COG2067@2|Bacteria,1NQ4A@1224|Proteobacteria,1RYKE@1236|Gammaproteobacteria,1XEJE@135618|Methylococcales	135618|Methylococcales	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
CH3_k127_10932120_6	236097.ADG881_2038	1.136e-55	196.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XJH4@135619|Oceanospirillales	135619|Oceanospirillales	K	at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA)	glnK-2	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
CH3_k127_10932120_0	697282.Mettu_3261	1.046e-245	768.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XE22@135618|Methylococcales	135618|Methylococcales	U	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CH3_k127_10932120_5	686340.Metal_2276	3.842e-59	207.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XF7U@135618|Methylococcales	135618|Methylococcales	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
CH3_k127_10932120_3	686340.Metal_2275	2.821e-214	671.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XEUM@135618|Methylococcales	135618|Methylococcales	P	PFAM Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CH3_k127_10932120_2	697282.Mettu_3871	1.048e-221	703.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1XEG5@135618|Methylococcales	135618|Methylococcales	O	SurA N-terminal domain	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
CH3_k127_10932120_9	1120963.KB894491_gene1005	2.441e-09	58.0	2EJ6D@1|root,33CXK@2|Bacteria,1NHGW@1224|Proteobacteria,1SGZR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10932120_10	861530.ALOZ01000027_gene420	7.884e-05	45.0	2EIAV@1|root,33C29@2|Bacteria,1VMAE@1239|Firmicutes,4HRG9@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_10932120_8	697282.Mettu_3872	3.717e-38	146.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,1XFIC@135618|Methylococcales	135618|Methylococcales	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CH3_k127_10932120_1	1116472.MGMO_21c00240	1.389e-235	733.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1XEIR@135618|Methylococcales	135618|Methylococcales	H	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CH3_k127_10932120_7	686340.Metal_0993	1.363e-54	200.0	COG0457@1|root,COG0457@2|Bacteria,1NPG5@1224|Proteobacteria,1SIX1@1236|Gammaproteobacteria,1XF77@135618|Methylococcales	135618|Methylococcales	S	Plant specific mitochondrial import receptor subunit TOM20	-	-	-	-	-	-	-	-	-	-	-	-	TOM20_plant
CH3_k127_10961983_5	697282.Mettu_1546	3.694e-12	73.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Periplasmic or secreted lipoprotein	yraP	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	BON
CH3_k127_10961983_3	857087.Metme_4556	4.478e-98	323.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,1XF2K@135618|Methylococcales	135618|Methylococcales	G	isomerase	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
CH3_k127_10961983_4	1116472.MGMO_147c00070	4.173e-33	132.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria,1XFD7@135618|Methylococcales	135618|Methylococcales	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
CH3_k127_10961983_1	697282.Mettu_1534	6.949e-134	447.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1XDPW@135618|Methylococcales	135618|Methylococcales	M	LppC putative lipoprotein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
CH3_k127_10961983_2	697282.Mettu_1533	2.046e-115	378.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1XDW1@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
CH3_k127_10961983_0	768671.ThimaDRAFT_2046	2.928e-298	934.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1S0W3@1236|Gammaproteobacteria,1WX5N@135613|Chromatiales	135613|Chromatiales	KL	DNA RNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SWIM
CH3_k127_11079326_4	697282.Mettu_0770	1.542e-117	387.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1XDVY@135618|Methylococcales	135618|Methylococcales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
CH3_k127_11079326_0	857087.Metme_1640	1.019e-187	593.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1XDM6@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
CH3_k127_11079326_6	686340.Metal_2405	4.907e-95	323.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,1XESS@135618|Methylococcales	135618|Methylococcales	S	Belongs to the CDS family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CH3_k127_11079326_5	697282.Mettu_0767	2.48e-103	341.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1XEM4@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
CH3_k127_11079326_7	697282.Mettu_0766	4.064e-82	276.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1XEV5@135618|Methylococcales	135618|Methylococcales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
CH3_k127_11079326_3	857087.Metme_1636	2.544e-124	402.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1XDK8@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CH3_k127_11079326_2	697282.Mettu_0764	1.298e-130	422.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1XE51@135618|Methylococcales	135618|Methylococcales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
CH3_k127_11079326_1	1116472.MGMO_105c00750	2.379e-136	436.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1XDV8@135618|Methylococcales	135618|Methylococcales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
CH3_k127_11079326_8	1122201.AUAZ01000020_gene2710	8.94e-48	174.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,46498@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CH3_k127_11102232_2	697282.Mettu_1258	1.602e-21	96.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1XFCM@135618|Methylococcales	135618|Methylococcales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
CH3_k127_11102232_1	1116472.MGMO_5c00120	8.012e-38	142.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,1XFK5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
CH3_k127_11102232_0	1116472.MGMO_2c00060	4.961e-141	456.0	COG3206@1|root,COG3206@2|Bacteria,1QJKV@1224|Proteobacteria,1THMG@1236|Gammaproteobacteria,1XEV1@135618|Methylococcales	135618|Methylococcales	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11128208_2	261292.Nit79A3_1165	3.565e-191	606.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,2VMH5@28216|Betaproteobacteria,372SW@32003|Nitrosomonadales	28216|Betaproteobacteria	E	PFAM Peptidase M18	-	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
CH3_k127_11128208_5	686340.Metal_0847	1.839e-68	234.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1XFDJ@135618|Methylococcales	135618|Methylococcales	C	HAMAP Peptide methionine sulfoxide reductase msrB	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
CH3_k127_11128208_6	1121403.AUCV01000033_gene3627	2.263e-65	227.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2WNCX@28221|Deltaproteobacteria,2MJVF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Appr-1-p processing domain protein	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
CH3_k127_11128208_7	1116472.MGMO_41c00230	1.419e-22	102.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEM2@135618|Methylococcales	1236|Gammaproteobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,Response_reg
CH3_k127_11128208_1	1116472.MGMO_41c00220	3.622e-212	680.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CH3_k127_11128208_0	697282.Mettu_0634	0.0	1116.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1XDJZ@135618|Methylococcales	135618|Methylococcales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17,Glyco_tranf_2_3
CH3_k127_11128208_3	1121957.ATVL01000008_gene4308	4.415e-113	372.0	COG0500@1|root,COG2226@2|Bacteria,4NJTP@976|Bacteroidetes,47UFD@768503|Cytophagia	976|Bacteroidetes	Q	ubiE/COQ5 methyltransferase family	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25,Methyltransf_31
CH3_k127_11128208_4	1500281.JQKZ01000002_gene1573	7.617e-81	273.0	COG2020@1|root,COG2020@2|Bacteria,4NJCI@976|Bacteroidetes,1I1CA@117743|Flavobacteriia,3ZSUE@59732|Chryseobacterium	976|Bacteroidetes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CH3_k127_11190791_0	857087.Metme_2471	1.443e-121	393.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1S0AJ@1236|Gammaproteobacteria,1XH1J@135618|Methylococcales	135618|Methylococcales	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
CH3_k127_11190791_1	857087.Metme_2471	6.203e-50	187.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1S0AJ@1236|Gammaproteobacteria,1XH1J@135618|Methylococcales	135618|Methylococcales	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
CH3_k127_11190791_2	697282.Mettu_2415	1.021e-32	127.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1S1WF@1236|Gammaproteobacteria,1XDMB@135618|Methylococcales	135618|Methylococcales	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
CH3_k127_11190791_3	713587.THITH_04630	3.926e-20	100.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1S1WF@1236|Gammaproteobacteria,1X0A4@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
CH3_k127_11238799_1	697282.Mettu_2841	6.245e-228	718.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,1RM9Q@1236|Gammaproteobacteria,1XDSI@135618|Methylococcales	135618|Methylococcales	C	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
CH3_k127_11238799_2	243233.MCA1141	6.04e-137	441.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,1RPCY@1236|Gammaproteobacteria,1XE7T@135618|Methylococcales	135618|Methylococcales	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
CH3_k127_11238799_4	857087.Metme_1584	3.141e-70	244.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,1RRYF@1236|Gammaproteobacteria,1XENH@135618|Methylococcales	135618|Methylococcales	C	hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
CH3_k127_11238799_0	857087.Metme_1583	1.876e-234	733.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,1RPB3@1236|Gammaproteobacteria,1XDNQ@135618|Methylococcales	135618|Methylococcales	C	Proton-conducting membrane transporter	-	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
CH3_k127_11238799_3	697282.Mettu_2846	1.275e-125	412.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,1RSJ4@1236|Gammaproteobacteria,1XERA@135618|Methylococcales	135618|Methylococcales	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
CH3_k127_11273706_1	697282.Mettu_2792	2.711e-138	445.0	COG1907@1|root,COG1907@2|Bacteria,1MWHM@1224|Proteobacteria,1RQC1@1236|Gammaproteobacteria,1XEBT@135618|Methylococcales	135618|Methylococcales	S	GHMP kinases N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CH3_k127_11273706_4	686340.Metal_3525	6.636e-31	127.0	COG2232@1|root,COG2232@2|Bacteria,1R6Y7@1224|Proteobacteria,1S781@1236|Gammaproteobacteria,1XEV0@135618|Methylococcales	135618|Methylococcales	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
CH3_k127_11273706_3	686340.Metal_3525	1.048e-42	164.0	COG2232@1|root,COG2232@2|Bacteria,1R6Y7@1224|Proteobacteria,1S781@1236|Gammaproteobacteria,1XEV0@135618|Methylococcales	135618|Methylococcales	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
CH3_k127_11273706_0	697282.Mettu_2794	5.654e-178	561.0	COG3252@1|root,COG3252@2|Bacteria,1MUP6@1224|Proteobacteria,1S1PA@1236|Gammaproteobacteria,1XDU9@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016787,GO:0016810,GO:0016814,GO:0018759,GO:0019238,GO:0043446,GO:0044237,GO:0071704	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
CH3_k127_11273706_2	697282.Mettu_2795	5.083e-132	426.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1S30B@1236|Gammaproteobacteria,1XE5K@135618|Methylococcales	135618|Methylococcales	HJ	Belongs to the RimK family	-	-	-	-	-	-	-	-	-	-	-	-	RimK
CH3_k127_11273706_5	1116472.MGMO_92c00120	2.612e-13	71.0	COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,1S4ZR@1236|Gammaproteobacteria,1XDPE@135618|Methylococcales	135618|Methylococcales	H	ATP:dephospho-CoA triphosphoribosyl transferase	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
CH3_k127_11305466_6	697282.Mettu_0837	3.221e-09	64.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1XE2S@135618|Methylococcales	135618|Methylococcales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
CH3_k127_11305466_1	857087.Metme_1600	5.901e-136	446.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RPMH@1236|Gammaproteobacteria,1XGYU@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CH3_k127_11305466_2	857087.Metme_1599	2.239e-88	297.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1XDXZ@135618|Methylococcales	135618|Methylococcales	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CH3_k127_11305466_4	686340.Metal_3009	2.554e-71	245.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1S24R@1236|Gammaproteobacteria,1XFNI@135618|Methylococcales	135618|Methylococcales	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
CH3_k127_11305466_0	1116472.MGMO_60c00200	1.363e-267	833.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1XE58@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CH3_k127_11305466_3	857087.Metme_2792	1.931e-85	286.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1XEK8@135618|Methylococcales	135618|Methylococcales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CH3_k127_11305466_5	686340.Metal_3802	5.807e-10	66.0	COG3073@1|root,COG3073@2|Bacteria,1QICT@1224|Proteobacteria,1SJ3Y@1236|Gammaproteobacteria,1XFUY@135618|Methylococcales	135618|Methylococcales	T	Anti sigma-E protein RseA, N-terminal domain	-	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
CH3_k127_11317239_1	697282.Mettu_3151	7.136e-130	421.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1XE55@135618|Methylococcales	135618|Methylococcales	K	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair	rapA	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Helicase_C,RapA_C,SNF2_N
CH3_k127_11317239_0	1116472.MGMO_56c00040	5.929e-236	735.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1XG1Z@135618|Methylococcales	135618|Methylococcales	P	Chromate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Chromate_transp
CH3_k127_11317239_2	697282.Mettu_3968	1.094e-05	48.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,1XFME@135618|Methylococcales	135618|Methylococcales	C	Cytochrome b/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
CH3_k127_11325855_3	478741.JAFS01000002_gene286	8.404e-10	63.0	COG0790@1|root,COG0790@2|Bacteria,46SWR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Sel1 domain protein repeat-containing protein	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
CH3_k127_11325855_4	177437.HRM2_19790	4.239e-07	52.0	2EC1X@1|root,33612@2|Bacteria,1NER9@1224|Proteobacteria,42W14@68525|delta/epsilon subdivisions,2WRP1@28221|Deltaproteobacteria,2MKV6@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HicB
CH3_k127_11325855_2	525897.Dbac_0305	1.34e-12	71.0	COG1487@1|root,COG1487@2|Bacteria,1RHQJ@1224|Proteobacteria,42TEC@68525|delta/epsilon subdivisions,2WPE2@28221|Deltaproteobacteria,2MF3R@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CH3_k127_11325855_0	697282.Mettu_0157	2.073e-154	492.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,1XE3W@135618|Methylococcales	135618|Methylococcales	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CH3_k127_11325855_1	857087.Metme_1371	9.744e-99	327.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1XDYB@135618|Methylococcales	135618|Methylococcales	E	Belongs to the agmatine deiminase family	-	-	-	-	-	-	-	-	-	-	-	-	PAD_porph
CH3_k127_11350686_2	1116472.MGMO_141c00130	1.373e-32	130.0	COG3794@1|root,COG3794@2|Bacteria,1RF7V@1224|Proteobacteria,1S4VA@1236|Gammaproteobacteria,1XG9R@135618|Methylococcales	135618|Methylococcales	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11350686_3	1116472.MGMO_15c00030	2.669e-16	82.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1XDP4@135618|Methylococcales	135618|Methylococcales	L	PFAM Restriction endonuclease, type I, EcoRI, R subunit Type III, Res subunit, N-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N,ResIII
CH3_k127_11350686_5	1116472.MGMO_15c00040	1.507e-10	66.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1XDP4@135618|Methylococcales	135618|Methylococcales	L	PFAM Restriction endonuclease, type I, EcoRI, R subunit Type III, Res subunit, N-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N,ResIII
CH3_k127_11350686_4	1116472.MGMO_15c00040	1.263e-14	77.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1XDP4@135618|Methylococcales	135618|Methylococcales	L	PFAM Restriction endonuclease, type I, EcoRI, R subunit Type III, Res subunit, N-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N,ResIII
CH3_k127_11350686_7	572477.Alvin_3262	0.0002299	47.0	COG0732@1|root,COG0732@2|Bacteria,1Q4FB@1224|Proteobacteria,1RS7D@1236|Gammaproteobacteria,1WYGF@135613|Chromatiales	135613|Chromatiales	L	PFAM restriction modification system DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
CH3_k127_11350686_0	635013.TherJR_0997	6.84e-135	466.0	COG0395@1|root,COG5001@1|root,COG5002@1|root,COG0395@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,26021@186807|Peptococcaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9
CH3_k127_11350686_1	76114.ebA2921	4.054e-75	269.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,2VMS2@28216|Betaproteobacteria,2KV08@206389|Rhodocyclales	206389|Rhodocyclales	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
CH3_k127_11350686_6	1122164.JHWF01000019_gene483	2.203e-06	57.0	COG4191@1|root,COG4251@1|root,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,PAS,PAS_3,PAS_4,PAS_9,dCache_1
CH3_k127_11366236_1	243233.MCA1413	1.987e-104	342.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1XDQF@135618|Methylococcales	135618|Methylococcales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
CH3_k127_11366236_2	686340.Metal_0453	1.252e-88	297.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,1XDM5@135618|Methylococcales	135618|Methylococcales	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
CH3_k127_11366236_0	2340.JV46_05170	5.594e-186	588.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1J541@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_0998,iECNA114_1301.ECNA114_0940,iECSF_1327.ECSF_0829,iPC815.YPO1390	EPSP_synthase
CH3_k127_11389097_4	697282.Mettu_3516	1.293e-74	253.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1XDRW@135618|Methylococcales	135618|Methylococcales	D	G-rich domain on putative tyrosine kinase	-	-	-	ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,GNVR,Wzz
CH3_k127_11389097_5	278957.ABEA03000105_gene456	4.218e-22	111.0	COG3664@1|root,COG3664@2|Bacteria,46Y3P@74201|Verrucomicrobia,3K8VS@414999|Opitutae	414999|Opitutae	G	PFAM glycoside hydrolase family 39	-	-	-	ko:K21000	ko02025,map02025	-	-	-	ko00000,ko00001	-	GH39	-	-
CH3_k127_11389097_3	1144343.PMI41_02904	1.152e-80	286.0	COG2273@1|root,COG2273@2|Bacteria,1Q6IY@1224|Proteobacteria,2TVH1@28211|Alphaproteobacteria,43IPQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Hydrolase Family 16	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11389097_0	1218075.BAYA01000006_gene2306	7.684e-164	525.0	COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,2VM0Z@28216|Betaproteobacteria,1K0MP@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CH3_k127_11389097_1	640510.BC1001_5444	5.812e-93	321.0	COG2244@1|root,COG2244@2|Bacteria,1NEKX@1224|Proteobacteria,2WFIQ@28216|Betaproteobacteria,1K4Z6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Pfam Polysaccharide biosynthesis protein	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt,Polysacc_synt_C
CH3_k127_11389097_2	1125973.JNLC01000017_gene3577	4.815e-92	314.0	COG1216@1|root,COG1216@2|Bacteria,1RAM8@1224|Proteobacteria,2U5N6@28211|Alphaproteobacteria,3K3UI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CH3_k127_11396168_1	1116472.MGMO_85c00150	3.305e-115	380.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,1S0T1@1236|Gammaproteobacteria,1XDN7@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CH3_k127_11396168_0	857087.Metme_3844	2.086e-249	780.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1XDZX@135618|Methylococcales	135618|Methylococcales	P	PFAM Sulphate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
CH3_k127_11448965_0	686340.Metal_1979	3.921e-156	496.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,1XERX@135618|Methylococcales	135618|Methylococcales	E	Aminotransferase class-V	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
CH3_k127_11448965_1	1116472.MGMO_38c00220	6.617e-149	478.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RMGZ@1236|Gammaproteobacteria,1XEC8@135618|Methylococcales	135618|Methylococcales	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CH3_k127_11451955_2	1485545.JQLW01000005_gene857	2.992e-44	164.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria	1224|Proteobacteria	C	Fe-S oxidoreductase	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	iECABU_c1320.ECABU_c33760,iECIAI1_1343.ECIAI1_3119,iECIAI39_1322.ECIAI39_3465,iECNA114_1301.ECNA114_3053,iECP_1309.ECP_3055,iJN746.PP_3747	CCG,Fer4_7,Fer4_8
CH3_k127_11451955_0	671143.DAMO_1127	4.257e-107	354.0	COG0510@1|root,COG0510@2|Bacteria	2|Bacteria	M	ethanolamine kinase activity	-	-	2.7.1.89	ko:K07251	ko00730,ko01100,map00730,map01100	-	R02134	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	APH,Choline_kinase,EcKinase
CH3_k127_11451955_1	697282.Mettu_3361	2.941e-73	250.0	COG2945@1|root,COG2945@2|Bacteria,1QY8I@1224|Proteobacteria,1T534@1236|Gammaproteobacteria,1XF8C@135618|Methylococcales	135618|Methylococcales	S	Uncharacterised protein family (UPF0227)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0227
CH3_k127_11457539_4	686340.Metal_2192	5.158e-71	245.0	COG1652@1|root,COG3753@1|root,COG1652@2|Bacteria,COG3753@2|Bacteria,1RD8K@1224|Proteobacteria,1SENI@1236|Gammaproteobacteria,1XFVA@135618|Methylococcales	135618|Methylococcales	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	BON,LysM
CH3_k127_11457539_3	1123400.KB904780_gene1733	3.146e-103	342.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,4620H@72273|Thiotrichales	72273|Thiotrichales	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
CH3_k127_11457539_6	765911.Thivi_2180	4.941e-07	56.0	2DQK2@1|root,337DF@2|Bacteria,1ND02@1224|Proteobacteria,1SDUJ@1236|Gammaproteobacteria,1WZK2@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11457539_2	697282.Mettu_2336	4.935e-110	369.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1XE9D@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CH3_k127_11457539_1	697282.Mettu_2335	2.648e-148	478.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1XE09@135618|Methylococcales	135618|Methylococcales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CH3_k127_11457539_5	857087.Metme_4272	8.374e-38	145.0	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,1SCNZ@1236|Gammaproteobacteria,1XFHY@135618|Methylococcales	135618|Methylococcales	K	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
CH3_k127_11457539_0	243233.MCA0335	0.0	1778.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1XDNM@135618|Methylococcales	135618|Methylococcales	CEH	2 iron, 2 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
CH3_k127_11470112_5	697282.Mettu_3973	4.052e-08	54.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,1RPTD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase, gamma subunit	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
CH3_k127_11470112_2	697282.Mettu_3974	1.132e-75	261.0	COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,1RQ23@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitrate reductase	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
CH3_k127_11470112_1	697282.Mettu_3976	4.253e-290	897.0	COG1140@1|root,COG1140@2|Bacteria,1QZP4@1224|Proteobacteria	1224|Proteobacteria	C	4Fe-4S dicluster domain	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K16965,ko:K17051	ko00920,map00920	-	R09500	RC02555	ko00000,ko00001,ko02000	5.A.3.8	-	-	Fer4_11,Nitr_red_bet_C
CH3_k127_11470112_0	697282.Mettu_3977	0.0	2288.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,1RQ27@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
CH3_k127_11470112_4	111781.Lepto7376_1993	1.046e-12	68.0	2DCT2@1|root,32U08@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
CH3_k127_11470112_3	653733.Selin_2438	1.413e-28	114.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
CH3_k127_11479242_3	1116472.MGMO_88c00380	5.636e-36	136.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1XE54@135618|Methylococcales	135618|Methylococcales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CH3_k127_11479242_2	697282.Mettu_3207	1.263e-74	254.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1XEZP@135618|Methylococcales	135618|Methylococcales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
CH3_k127_11479242_4	697282.Mettu_3206	5.233e-28	115.0	COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1XFJU@135618|Methylococcales	135618|Methylococcales	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
CH3_k127_11479242_1	697282.Mettu_3205	2.005e-87	296.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1XEEM@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
CH3_k127_11479242_0	243233.MCA1848	1.608e-319	985.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XE3D@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CH3_k127_11539818_0	697282.Mettu_3446	0.0	1407.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1XEK9@135618|Methylococcales	135618|Methylococcales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
CH3_k127_11599508_0	1283300.ATXB01000002_gene2539	8.394e-112	374.0	COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,1RRH5@1236|Gammaproteobacteria,1XE6U@135618|Methylococcales	135618|Methylococcales	S	Phage terminase large subunit (GpA)	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_GpA
CH3_k127_11629252_1	522306.CAP2UW1_3223	2.204e-237	745.0	COG4913@1|root,COG4913@2|Bacteria,1N16Z@1224|Proteobacteria,2VJD2@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
CH3_k127_11629252_2	522306.CAP2UW1_3224	1.125e-88	298.0	2CB46@1|root,31GHU@2|Bacteria,1NGIC@1224|Proteobacteria,2VQSQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF4194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4194
CH3_k127_11629252_0	1454004.AW11_01864	7.098e-250	777.0	COG4942@1|root,COG4942@2|Bacteria,1MXRZ@1224|Proteobacteria,2VN9G@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
CH3_k127_11629252_3	1283300.ATXB01000001_gene400	3.922e-05	47.0	COG3548@1|root,COG3548@2|Bacteria	2|Bacteria	S	protein homotetramerization	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
CH3_k127_11645328_0	583355.Caka_2618	2.474e-61	220.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11645328_5	886293.Sinac_6171	1.691e-13	78.0	29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11645328_6	237368.SCABRO_02413	2.012e-10	72.0	29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11645328_2	236097.ADG881_3085	1.734e-33	134.0	COG2928@1|root,COG2928@2|Bacteria,1NF4R@1224|Proteobacteria,1SFUD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
CH3_k127_11645328_4	290398.Csal_0798	5.126e-17	87.0	COG3187@1|root,COG3187@2|Bacteria,1N9XV@1224|Proteobacteria,1S4T0@1236|Gammaproteobacteria,1XQDA@135619|Oceanospirillales	135619|Oceanospirillales	O	META domain	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	META,NlpE,NlpE_C,YscW
CH3_k127_11645328_1	690850.Desaf_0974	2.988e-42	158.0	2E8QN@1|root,3331M@2|Bacteria,1ND4I@1224|Proteobacteria,430TR@68525|delta/epsilon subdivisions,2WVZ7@28221|Deltaproteobacteria,2MF52@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11645328_3	690850.Desaf_0975	8.18e-21	94.0	2ADPE@1|root,313EG@2|Bacteria,1NEWZ@1224|Proteobacteria,42V0P@68525|delta/epsilon subdivisions,2WSFD@28221|Deltaproteobacteria,2MFC5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
CH3_k127_1164957_0	1116472.MGMO_17c00180	6.614e-312	962.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1XDY0@135618|Methylococcales	135618|Methylococcales	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CH3_k127_1164957_1	697282.Mettu_3365	5.306e-21	96.0	2C5IB@1|root,2ZVNU@2|Bacteria,1P5N1@1224|Proteobacteria,1SUUE@1236|Gammaproteobacteria,1XFP4@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11704514_2	338966.Ppro_0406	4.699e-61	211.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,42PYS@68525|delta/epsilon subdivisions,2WMEG@28221|Deltaproteobacteria,43UGD@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
CH3_k127_11704514_0	472759.Nhal_3094	2.981e-132	434.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,1RMKB@1236|Gammaproteobacteria,1WWEE@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
CH3_k127_11704514_1	335543.Sfum_2956	6.506e-124	403.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,2MQ9F@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
CH3_k127_11707711_0	697282.Mettu_3364	1.476e-294	914.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XDS9@135618|Methylococcales	135618|Methylococcales	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CH3_k127_11707711_1	686340.Metal_3517	6.698e-96	318.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1XE7H@135618|Methylococcales	135618|Methylococcales	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
CH3_k127_11707711_2	686340.Metal_2964	1.958e-84	289.0	COG1266@1|root,COG1266@2|Bacteria,1R6Z1@1224|Proteobacteria,1RRIS@1236|Gammaproteobacteria,1XF2M@135618|Methylococcales	135618|Methylococcales	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CH3_k127_11707711_3	686340.Metal_3361	5.758e-63	220.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1XEYS@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
CH3_k127_11707711_4	697281.Mahau_1514	7.832e-63	229.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,42FBY@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Polynucleotide adenylyltransferase region	-	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
CH3_k127_11762192_1	686340.Metal_1013	1.935e-246	766.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1XDJW@135618|Methylococcales	135618|Methylococcales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
CH3_k127_11762192_0	686340.Metal_1012	5.852e-272	843.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1XE4R@135618|Methylococcales	135618|Methylococcales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
CH3_k127_11762192_2	697282.Mettu_2790	2.366e-22	102.0	COG1665@1|root,COG1665@2|Bacteria,1RCBC@1224|Proteobacteria,1S28R@1236|Gammaproteobacteria,1XDNV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
CH3_k127_11770354_0	697282.Mettu_1217	2.391e-177	563.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1XEV7@135618|Methylococcales	135618|Methylococcales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
CH3_k127_11770354_3	686340.Metal_2420	1.546e-28	116.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1SH3F@1236|Gammaproteobacteria,1XFJ9@135618|Methylococcales	135618|Methylococcales	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
CH3_k127_11770354_1	697282.Mettu_0846	5.158e-104	342.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1XEB3@135618|Methylococcales	135618|Methylococcales	E	subfamily IB	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CH3_k127_11770354_2	857087.Metme_3714	1.44e-47	171.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1XENV@135618|Methylococcales	135618|Methylococcales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
CH3_k127_11793520_0	768671.ThimaDRAFT_4355	2.345e-242	764.0	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,1SKFJ@1236|Gammaproteobacteria,1X099@135613|Chromatiales	135613|Chromatiales	L	COG0841 Cation multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CH3_k127_11814463_0	1454004.AW11_02393	3.811e-70	241.0	COG4313@1|root,COG4313@2|Bacteria,1PRCN@1224|Proteobacteria,2VQHT@28216|Betaproteobacteria,1KQK1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
CH3_k127_11814463_3	105559.Nwat_0848	7.556e-22	101.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,1T9MI@1236|Gammaproteobacteria,1X1I2@135613|Chromatiales	135613|Chromatiales	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG
CH3_k127_11814463_1	525897.Dbac_1078	5.016e-54	196.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2WNWH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	(twin-arginine translocation) pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11814463_2	1496688.ER33_08635	7.664e-31	122.0	COG4320@1|root,COG4320@2|Bacteria,1G0BG@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
CH3_k127_11826129_8	765913.ThidrDRAFT_2345	2.072e-13	74.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WX7G@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC2	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CH3_k127_11826129_1	857087.Metme_0695	4.39e-204	642.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1XDN0@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
CH3_k127_11826129_5	697282.Mettu_0178	8.892e-106	346.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1XDZP@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
CH3_k127_11826129_0	697282.Mettu_0179	1.02e-221	692.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1XE8B@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
CH3_k127_11826129_7	697282.Mettu_0180	3.974e-24	106.0	COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,1SGH6@1236|Gammaproteobacteria,1XFQI@135618|Methylococcales	135618|Methylococcales	S	STAS domain	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
CH3_k127_11826129_6	1116472.MGMO_55c00050	6.408e-66	228.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1XEZ9@135618|Methylococcales	135618|Methylococcales	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
CH3_k127_11826129_3	857087.Metme_0700	2.752e-128	415.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,1XDZ6@135618|Methylococcales	135618|Methylococcales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
CH3_k127_11826129_4	697282.Mettu_0183	3.475e-128	417.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1XET4@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CH3_k127_11826129_2	686340.Metal_0240	2.923e-152	486.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1XDSG@135618|Methylococcales	135618|Methylococcales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
CH3_k127_11828029_3	697282.Mettu_3652	5.84e-56	198.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1XF84@135618|Methylococcales	135618|Methylococcales	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
CH3_k127_11828029_4	857087.Metme_1546	8.781e-30	119.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,1XFHK@135618|Methylococcales	135618|Methylococcales	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
CH3_k127_11828029_1	697282.Mettu_3650	1.37e-90	307.0	2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1XER1@135618|Methylococcales	135618|Methylococcales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
CH3_k127_11828029_2	697282.Mettu_3649	2.324e-61	215.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1XF4M@135618|Methylococcales	135618|Methylococcales	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
CH3_k127_11828029_0	857087.Metme_1549	1.671e-155	496.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,1RP2S@1236|Gammaproteobacteria,1XEND@135618|Methylococcales	135618|Methylococcales	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
CH3_k127_11955417_6	697282.Mettu_3413	2.933e-37	152.0	COG0484@1|root,COG0790@1|root,COG0484@2|Bacteria,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria,1XFHF@135618|Methylococcales	135618|Methylococcales	O	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	DnaJ,Sel1
CH3_k127_11955417_0	686340.Metal_2202	0.0	1039.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1XEBM@135618|Methylococcales	135618|Methylococcales	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
CH3_k127_11955417_4	686340.Metal_3347	1.173e-65	231.0	2DN0A@1|root,32UPR@2|Bacteria,1N1BR@1224|Proteobacteria,1S9NG@1236|Gammaproteobacteria,1XFDP@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_11955417_1	686340.Metal_3346	2.17e-277	861.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQ9@1236|Gammaproteobacteria,1XEUF@135618|Methylococcales	135618|Methylococcales	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
CH3_k127_11955417_5	1283300.ATXB01000001_gene487	3.722e-51	187.0	COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,1SBJR@1236|Gammaproteobacteria,1XGZN@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
CH3_k127_11955417_3	697282.Mettu_0268	7.047e-69	239.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,1RZBF@1236|Gammaproteobacteria,1XF7J@135618|Methylococcales	135618|Methylococcales	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
CH3_k127_11955417_2	697282.Mettu_0269	1.496e-192	609.0	COG1488@1|root,COG1488@2|Bacteria,1QJI0@1224|Proteobacteria,1THHZ@1236|Gammaproteobacteria,1XE4J@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
CH3_k127_11955417_7	686340.Metal_0111	8.587e-12	68.0	COG2214@1|root,COG2214@2|Bacteria,1RDYT@1224|Proteobacteria,1T30D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	heat shock protein DnaJ	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1200836_3	857087.Metme_4105	8.393e-122	396.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1XDTT@135618|Methylococcales	135618|Methylococcales	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
CH3_k127_1200836_0	686340.Metal_2066	3.556e-257	803.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XER8@135618|Methylococcales	135618|Methylococcales	JKL	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
CH3_k127_1200836_2	1485545.JQLW01000010_gene1512	9.144e-163	538.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria	1224|Proteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily	bicA	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp,cNMP_binding
CH3_k127_1200836_1	697282.Mettu_2412	4.668e-201	636.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1XEI9@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
CH3_k127_1200836_4	697282.Mettu_2411	1.727e-92	317.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1XF27@135618|Methylococcales	135618|Methylococcales	D	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CH3_k127_12019083_3	697282.Mettu_0671	1.695e-15	81.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1XES6@135618|Methylococcales	135618|Methylococcales	K	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
CH3_k127_12019083_2	1116472.MGMO_8c00110	5.435e-17	86.0	29SVM@1|root,30E1S@2|Bacteria,1QJS6@1224|Proteobacteria,1THTG@1236|Gammaproteobacteria,1XFNE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12019083_0	697282.Mettu_1839	0.0	1070.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1XEBD@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
CH3_k127_12019083_1	857087.Metme_2613	1.232e-70	243.0	2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,1S80C@1236|Gammaproteobacteria,1XFEZ@135618|Methylococcales	135618|Methylococcales	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
CH3_k127_12019083_4	697282.Mettu_2516	7.658e-10	61.0	COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1XF52@135618|Methylococcales	135618|Methylococcales	S	CYTH	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
CH3_k127_1205120_5	697282.Mettu_0330	3.025e-95	318.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,1RYAA@1236|Gammaproteobacteria,1XEVU@135618|Methylococcales	135618|Methylococcales	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
CH3_k127_1205120_9	686340.Metal_2659	4.907e-40	153.0	2EBZ4@1|root,335YD@2|Bacteria,1NNWD@1224|Proteobacteria,1SJ3V@1236|Gammaproteobacteria,1XFPK@135618|Methylococcales	135618|Methylococcales	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
CH3_k127_1205120_0	323848.Nmul_A1679	4.714e-219	694.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VJA1@28216|Betaproteobacteria,372T6@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Multicopper oxidase, type	sufI	-	1.3.3.5	ko:K04753,ko:K08100,ko:K14588	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
CH3_k127_1205120_6	697282.Mettu_1997	3.57e-66	229.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1XF82@135618|Methylococcales	135618|Methylococcales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
CH3_k127_1205120_2	857087.Metme_4430	6.597e-143	456.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,1XEA2@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
CH3_k127_1205120_3	686340.Metal_0485	2.078e-127	411.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1XEIT@135618|Methylococcales	135618|Methylococcales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CH3_k127_1205120_4	697282.Mettu_1604	6.269e-113	379.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1XEBR@135618|Methylococcales	135618|Methylococcales	PT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
CH3_k127_1205120_7	697282.Mettu_2343	3.246e-55	196.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,1S5W4@1236|Gammaproteobacteria,1XFBP@135618|Methylococcales	135618|Methylococcales	OU	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
CH3_k127_1205120_1	857087.Metme_0294	1.48e-146	469.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1XEH8@135618|Methylococcales	135618|Methylococcales	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
CH3_k127_12051292_0	697282.Mettu_0759	2.097e-187	592.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1XDU0@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03184	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R06146,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
CH3_k127_12051292_1	686340.Metal_3979	4.54e-123	399.0	COG2271@1|root,COG2271@2|Bacteria,1MUEK@1224|Proteobacteria,1RMB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major facilitator superfamily	ttuB	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CH3_k127_12054602_3	697282.Mettu_2370	1.109e-34	133.0	COG1629@1|root,COG4771@2|Bacteria,1MXSN@1224|Proteobacteria,1RZC0@1236|Gammaproteobacteria,1XFZW@135618|Methylococcales	135618|Methylococcales	M	PFAM TonB-dependent receptor, beta-barrel	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
CH3_k127_12054602_1	697282.Mettu_2372	4.225e-134	439.0	COG4409@1|root,COG4409@2|Bacteria,1MVUD@1224|Proteobacteria,1S27X@1236|Gammaproteobacteria,1XF6U@135618|Methylococcales	135618|Methylococcales	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12054602_2	1116472.MGMO_91c00060	5.642e-54	195.0	COG0526@1|root,COG0526@2|Bacteria,1MZ9B@1224|Proteobacteria,1SBA1@1236|Gammaproteobacteria,1XFEH@135618|Methylococcales	135618|Methylococcales	CO	thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12054602_0	765911.Thivi_1324	2.666e-178	563.0	COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,1RQ1S@1236|Gammaproteobacteria,1WWPV@135613|Chromatiales	135613|Chromatiales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,Cyc-maltodext_C,Cyc-maltodext_N
CH3_k127_12065140_2	1116472.MGMO_154c00010	2.596e-134	434.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1XEGN@135618|Methylococcales	135618|Methylococcales	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CH3_k127_12065140_1	857087.Metme_2837	3.685e-184	581.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1THGR@1236|Gammaproteobacteria,1XDV9@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CH3_k127_12065140_0	697282.Mettu_1040	5.82e-229	715.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1XEDH@135618|Methylococcales	135618|Methylococcales	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
CH3_k127_12065140_4	472759.Nhal_2525	1.75e-32	128.0	2DPG5@1|root,331XR@2|Bacteria,1N90T@1224|Proteobacteria,1SDWF@1236|Gammaproteobacteria,1WZIR@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CH3_k127_12065140_3	324925.Ppha_1098	9.474e-43	156.0	2E3EN@1|root,32YDN@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
CH3_k127_12065140_5	1307437.J139_19456	1.722e-07	53.0	2F9Y6@1|root,3427F@2|Bacteria,1NZM0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12080386_1	472759.Nhal_1553	2.961e-54	196.0	COG3659@1|root,COG3659@2|Bacteria,1QIBX@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Carbohydrate-selective porin OprB	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
CH3_k127_12080386_0	522306.CAP2UW1_1285	2.582e-316	989.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,2WHVC@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
CH3_k127_12094123_0	857087.Metme_4024	5.922e-77	276.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XEBN@135618|Methylococcales	135618|Methylococcales	NU	COG3170 Tfp pilus assembly protein FimV	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	-
CH3_k127_12123777_4	1072685.IX83_01610	1.116e-07	53.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,3T1RK@506|Alcaligenaceae	28216|Betaproteobacteria	S	ABC transporter, ATP-binding protein	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
CH3_k127_12123777_0	697282.Mettu_4258	1.849e-164	525.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1XET3@135618|Methylococcales	135618|Methylococcales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
CH3_k127_12123777_2	857087.Metme_1898	2.358e-88	296.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,1XEZN@135618|Methylococcales	135618|Methylococcales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CH3_k127_12123777_3	857087.Metme_0927	2.702e-23	107.0	COG0513@1|root,COG0513@2|Bacteria,1QIY5@1224|Proteobacteria,1TGUS@1236|Gammaproteobacteria,1XGRE@135618|Methylococcales	135618|Methylococcales	JKL	DbpA RNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DbpA
CH3_k127_12123777_1	857087.Metme_0928	2.492e-98	327.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1XDXC@135618|Methylococcales	135618|Methylococcales	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
CH3_k127_12135849_3	933262.AXAM01000053_gene2703	4.897e-45	170.0	COG2995@1|root,COG2995@2|Bacteria,1N2QU@1224|Proteobacteria,43BAA@68525|delta/epsilon subdivisions,2X6PG@28221|Deltaproteobacteria,2MNJC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
CH3_k127_12135849_2	384676.PSEEN4697	7.491e-62	219.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	paraquat-inducible protein A	yebS	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
CH3_k127_12135849_0	1278309.KB907105_gene1464	4.461e-196	642.0	COG3008@1|root,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1XJ1N@135619|Oceanospirillales	135619|Oceanospirillales	Q	Paraquat-inducible protein B	-	-	-	-	-	-	-	-	-	-	-	-	MlaD
CH3_k127_12135849_4	857087.Metme_2845	3.704e-34	134.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,1XFJK@135618|Methylococcales	135618|Methylococcales	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
CH3_k127_12135849_1	686340.Metal_2921	7.028e-192	606.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1XDYP@135618|Methylococcales	135618|Methylococcales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CH3_k127_12175960_0	697282.Mettu_1901	4.657e-95	313.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1XDV2@135618|Methylococcales	135618|Methylococcales	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
CH3_k127_12175960_1	1123487.KB892846_gene545	3.336e-45	173.0	28IZ5@1|root,2Z8WP@2|Bacteria,1R6WI@1224|Proteobacteria,2W9TK@28216|Betaproteobacteria,2KZMC@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12175960_2	686340.Metal_3214	2.588e-17	81.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1XEF2@135618|Methylococcales	135618|Methylococcales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
CH3_k127_12191200_3	697282.Mettu_1253	4.887e-17	81.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1SJRD@1236|Gammaproteobacteria,1XEFB@135618|Methylococcales	135618|Methylococcales	M	Acyl- acyl-carrier-protein --UDP-N-acetylglucosamine O-acyltransferase	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
CH3_k127_12191200_4	795797.C497_11453	1.09e-14	79.0	COG0589@1|root,arCOG02053@2157|Archaea,2XZF2@28890|Euryarchaeota,23X0A@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CH3_k127_12191200_0	1121378.KB899703_gene2290	1.57e-140	462.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
CH3_k127_12191200_2	1122951.ATUE01000006_gene1268	1.158e-27	117.0	COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,1S64S@1236|Gammaproteobacteria,3NT6E@468|Moraxellaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF934
CH3_k127_12191200_1	857087.Metme_0277	1.56e-99	326.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,1XEB1@135618|Methylococcales	135618|Methylococcales	C	reductase 4Fe-4S	-	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
CH3_k127_12237716_0	879212.DespoDRAFT_00173	1.616e-222	704.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2MJCW@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM N-6 DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
CH3_k127_12237716_2	697282.Mettu_0377	6.084e-66	243.0	COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria,1XF9U@135618|Methylococcales	135618|Methylococcales	C	ATP synthase	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
CH3_k127_12237716_1	1415778.JQMM01000001_gene2181	1.428e-217	687.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA1	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CH3_k127_12237716_3	472759.Nhal_2237	3.328e-23	103.0	COG0711@1|root,COG0712@1|root,COG0711@2|Bacteria,COG0712@2|Bacteria,1R6C0@1224|Proteobacteria,1S4NA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
CH3_k127_12243295_2	686340.Metal_1990	2.914e-62	220.0	COG5544@1|root,COG5544@2|Bacteria,1QU58@1224|Proteobacteria,1RYPH@1236|Gammaproteobacteria,1XDSJ@135618|Methylococcales	135618|Methylococcales	S	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12243295_0	857087.Metme_3575	8.621e-179	564.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XE3A@135618|Methylococcales	135618|Methylococcales	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
CH3_k127_12243295_1	857087.Metme_0760	1.202e-98	324.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XEFM@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CH3_k127_12243386_0	686340.Metal_0798	9.707e-143	453.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,1RQ01@1236|Gammaproteobacteria,1XE9J@135618|Methylococcales	135618|Methylococcales	P	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
CH3_k127_12243386_1	1173023.KE650771_gene4901	3.843e-101	336.0	COG1682@1|root,COG1682@2|Bacteria,1G23R@1117|Cyanobacteria	1117|Cyanobacteria	GM	Transport permease protein	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
CH3_k127_12243386_2	269799.Gmet_1314	2.789e-50	182.0	COG2445@1|root,COG2445@2|Bacteria,1QQTT@1224|Proteobacteria,432AW@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
CH3_k127_12243386_3	324925.Ppha_1589	8.215e-20	92.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF86,NTP_transf_2
CH3_k127_12285448_1	1116472.MGMO_154c00060	5.261e-89	301.0	COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,1RZ6E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TIGRFAM TIGR00266 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
CH3_k127_12285448_0	697282.Mettu_3984	1.493e-147	472.0	COG0428@1|root,COG0428@2|Bacteria,1MWEZ@1224|Proteobacteria,1RNXU@1236|Gammaproteobacteria,1XE1K@135618|Methylococcales	135618|Methylococcales	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
CH3_k127_12285448_2	522306.CAP2UW1_0879	2.176e-78	267.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,1KR3X@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
CH3_k127_12285448_4	857087.Metme_0342	6.725e-28	114.0	COG0236@1|root,COG0236@2|Bacteria,1QSUN@1224|Proteobacteria,1SRZI@1236|Gammaproteobacteria,1XGM4@135618|Methylococcales	135618|Methylococcales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CH3_k127_12285448_3	857087.Metme_0343	1.645e-30	132.0	COG1020@1|root,COG1020@2|Bacteria,1NK69@1224|Proteobacteria,1SKZR@1236|Gammaproteobacteria,1XFVG@135618|Methylococcales	135618|Methylococcales	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12302880_5	697282.Mettu_2345	4.456e-12	70.0	2BHCG@1|root,32BE5@2|Bacteria,1QJTG@1224|Proteobacteria,1THUR@1236|Gammaproteobacteria,1XFSJ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12302880_1	697282.Mettu_0781	6.177e-166	526.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1XEKQ@135618|Methylococcales	135618|Methylococcales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0044271,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
CH3_k127_12302880_3	697282.Mettu_2543	1.128e-142	465.0	COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,1RMQY@1236|Gammaproteobacteria,1XEHT@135618|Methylococcales	135618|Methylococcales	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs	cmoB	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_9
CH3_k127_12302880_0	697282.Mettu_0016	1.831e-246	765.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1XE6C@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
CH3_k127_12302880_2	697282.Mettu_2391	3.432e-151	484.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1XDVU@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
CH3_k127_12302880_4	156889.Mmc1_0053	8.066e-41	156.0	COG5421@1|root,COG5421@2|Bacteria,1R6MI@1224|Proteobacteria,2UCZG@28211|Alphaproteobacteria	1224|Proteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CH3_k127_12318882_0	472759.Nhal_0405	9.195e-210	672.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1WW36@135613|Chromatiales	135613|Chromatiales	E	PFAM NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
CH3_k127_1232577_4	697282.Mettu_2626	6.583e-147	469.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1XDUC@135618|Methylococcales	135618|Methylococcales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CH3_k127_1232577_1	686340.Metal_0050	2.753e-202	636.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1XDRA@135618|Methylococcales	135618|Methylococcales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
CH3_k127_1232577_0	686340.Metal_3591	1.2e-219	686.0	28JC0@1|root,2Z96N@2|Bacteria,1R6FS@1224|Proteobacteria,1RR1V@1236|Gammaproteobacteria,1XEM8@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Ammonia monooxygenase particulate methane monooxygenase, subunit B	-	-	-	ko:K10945	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	Monooxygenase_B
CH3_k127_1232577_5	697282.Mettu_2427	1.075e-140	448.0	28JPK@1|root,2Z9FM@2|Bacteria,1N0EP@1224|Proteobacteria,1S1WY@1236|Gammaproteobacteria,1XDRM@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Ammonia monooxygenase particulate methane monooxygenase, subunit A	-	GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494	1.14.18.3,1.14.99.39	ko:K10944	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	AMO
CH3_k127_1232577_3	697282.Mettu_2426	7.888e-148	469.0	arCOG08699@1|root,2Z9T7@2|Bacteria,1R73C@1224|Proteobacteria,1S05W@1236|Gammaproteobacteria,1XDMD@135618|Methylococcales	135618|Methylococcales	C	methane monooxygenase, subunit C	-	-	-	ko:K10946	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	AmoC
CH3_k127_1232577_9	686340.Metal_3594	1.259e-34	137.0	2CKZD@1|root,2ZDSM@2|Bacteria,1P7JG@1224|Proteobacteria,1SVVK@1236|Gammaproteobacteria,1XFAP@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1232577_2	697282.Mettu_2388	2.058e-183	586.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1XDPA@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
CH3_k127_1232577_8	697282.Mettu_2389	5.325e-91	302.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,1S3PE@1236|Gammaproteobacteria,1XE1Z@135618|Methylococcales	135618|Methylococcales	T	response regulator	-	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
CH3_k127_1232577_6	857087.Metme_1840	8.777e-121	392.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria,1XEHR@135618|Methylococcales	135618|Methylococcales	S	MazG nucleotide pyrophosphohydrolase domain	-	-	3.6.1.9	ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
CH3_k127_1232577_7	697282.Mettu_2494	1.255e-92	306.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1XDKQ@135618|Methylococcales	135618|Methylococcales	G	pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CH3_k127_12338769_0	697282.Mettu_1865	9.563e-229	718.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1XEDN@135618|Methylococcales	135618|Methylococcales	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
CH3_k127_12338769_2	686340.Metal_0852	1.959e-60	214.0	2E6CY@1|root,3310K@2|Bacteria,1NFYR@1224|Proteobacteria,1SIZ7@1236|Gammaproteobacteria,1XERQ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12338769_1	857087.Metme_0453	2.085e-108	358.0	COG3794@1|root,COG3794@2|Bacteria,1RFFF@1224|Proteobacteria,1SN7W@1236|Gammaproteobacteria,1XDM9@135618|Methylococcales	135618|Methylococcales	C	PFAM multicopper oxidase type 2	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12338769_3	243233.MCA0636	2.76e-47	173.0	COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,1SCPK@1236|Gammaproteobacteria,1XFAV@135618|Methylococcales	135618|Methylococcales	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12338769_4	697282.Mettu_1861	9.069e-06	47.0	2CCJR@1|root,2ZCU4@2|Bacteria,1RC7F@1224|Proteobacteria,1S3JC@1236|Gammaproteobacteria,1XDT3@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1234069_0	686340.Metal_3401	7.32e-212	661.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1XE92@135618|Methylococcales	135618|Methylococcales	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
CH3_k127_1234069_3	1167006.UWK_00289	7.308e-36	139.0	COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria	1224|Proteobacteria	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
CH3_k127_1234069_1	686340.Metal_0445	9.627e-115	396.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,EAL,GGDEF,HAMP
CH3_k127_1234069_2	697282.Mettu_0915	1.826e-77	262.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1XDX5@135618|Methylococcales	135618|Methylococcales	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CH3_k127_12380845_0	1437824.BN940_10591	1.478e-186	591.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2W02U@28216|Betaproteobacteria,3T8BI@506|Alcaligenaceae	28216|Betaproteobacteria	M	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
CH3_k127_12380845_1	1127673.GLIP_2083	6.367e-20	93.0	COG4469@1|root,COG4469@2|Bacteria,1RFB6@1224|Proteobacteria,1S55Q@1236|Gammaproteobacteria,468QU@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Competence protein	-	-	-	-	-	-	-	-	-	-	-	-	CoiA
CH3_k127_12395128_0	1116472.MGMO_128c00210	1.211e-230	721.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1XDNE@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	-	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
CH3_k127_12395128_5	686340.Metal_2688	1.576e-45	167.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1XFKP@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
CH3_k127_12395128_4	857087.Metme_0272	4.257e-47	174.0	COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,1S8ZI@1236|Gammaproteobacteria,1XFMR@135618|Methylococcales	135618|Methylococcales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CH3_k127_12395128_3	697282.Mettu_2407	3.58e-71	243.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1XEZ2@135618|Methylococcales	135618|Methylococcales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
CH3_k127_12395128_1	697282.Mettu_2406	6.202e-139	456.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1XDRI@135618|Methylococcales	135618|Methylococcales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CH3_k127_12395128_6	857087.Metme_3847	3.76e-33	137.0	28UGB@1|root,2ZGM6@2|Bacteria,1P6GP@1224|Proteobacteria,1STQN@1236|Gammaproteobacteria,1XFII@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12395128_7	1116472.MGMO_168c00030	5.39e-24	104.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,1SC8Q@1236|Gammaproteobacteria,1XFQK@135618|Methylococcales	135618|Methylococcales	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
CH3_k127_12395128_2	686340.Metal_3930	3.725e-123	403.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1T1NU@1236|Gammaproteobacteria,1XEVX@135618|Methylococcales	135618|Methylococcales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
CH3_k127_12409290_4	2340.JV46_19330	3.18e-11	67.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1J559@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSSON_1240.SSON_1444,iYL1228.KPN_02176	Phe_tRNA-synt_N,tRNA-synt_2d
CH3_k127_12409290_2	675812.VHA_002816	2.471e-51	183.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1XX9W@135623|Vibrionales	135623|Vibrionales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
CH3_k127_12409290_3	395493.BegalDRAFT_3331	1.838e-17	85.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,461EZ@72273|Thiotrichales	72273|Thiotrichales	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
CH3_k127_12409290_1	572477.Alvin_0981	5.382e-62	218.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1WWSS@135613|Chromatiales	135613|Chromatiales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CH3_k127_12409290_0	1415778.JQMM01000001_gene1975	1.838e-162	515.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
CH3_k127_12416115_0	697282.Mettu_0058	1.188e-230	723.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1XE2C@135618|Methylococcales	135618|Methylococcales	KL	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2
CH3_k127_12416115_5	697282.Mettu_0059	3.152e-85	287.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1XDV7@135618|Methylococcales	135618|Methylococcales	O	Glycoprotease family	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
CH3_k127_12416115_3	697282.Mettu_2566	1.247e-94	314.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1XDVQ@135618|Methylococcales	135618|Methylococcales	J	Belongs to the SUA5 family	-	-	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
CH3_k127_12416115_1	686340.Metal_3704	2.648e-107	350.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1XE0T@135618|Methylococcales	135618|Methylococcales	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12416115_2	697282.Mettu_2568	4.267e-106	352.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1XEA4@135618|Methylococcales	135618|Methylococcales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
CH3_k127_12416115_4	523794.Lebu_2206	1.691e-85	299.0	COG0695@1|root,COG0695@2|Bacteria,37BQC@32066|Fusobacteria	32066|Fusobacteria	O	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
CH3_k127_12451012_2	314278.NB231_06775	1.253e-29	123.0	COG1017@1|root,COG1017@2|Bacteria,1NA56@1224|Proteobacteria,1SDRC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitric oxide dioxygenase activity	VPA1107	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12451012_0	686340.Metal_0835	7.191e-73	248.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,1XENF@135618|Methylococcales	135618|Methylococcales	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
CH3_k127_12471241_0	765914.ThisiDRAFT_2476	1.501e-317	992.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1WY9Q@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC
CH3_k127_12471241_1	697282.Mettu_0020	4.261e-258	811.0	COG1629@1|root,COG4771@2|Bacteria,1QTS8@1224|Proteobacteria,1T1FF@1236|Gammaproteobacteria,1XDZE@135618|Methylococcales	135618|Methylococcales	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
CH3_k127_12494789_1	765910.MARPU_16205	1.786e-109	376.0	COG3264@1|root,COG3264@2|Bacteria,1QWCW@1224|Proteobacteria,1T3T8@1236|Gammaproteobacteria,1X2V1@135613|Chromatiales	135613|Chromatiales	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
CH3_k127_12494789_5	237368.SCABRO_02413	3.019e-13	70.0	29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12494789_3	1283300.ATXB01000001_gene399	4.701e-64	226.0	2DKXW@1|root,30TMD@2|Bacteria,1R3IE@1224|Proteobacteria,1SPK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4410)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4410
CH3_k127_12494789_0	1283300.ATXB01000001_gene387	2.807e-167	534.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,1RP9M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
CH3_k127_12494789_4	1283300.ATXB01000001_gene398	4.668e-50	189.0	2ANC7@1|root,31DAQ@2|Bacteria,1NAR3@1224|Proteobacteria,1SWCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_12494789_2	1283300.ATXB01000001_gene397	1.673e-107	355.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,1SB83@1236|Gammaproteobacteria,1XGK1@135618|Methylococcales	135618|Methylococcales	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
CH3_k127_12521336_9	697282.Mettu_1392	1.434e-27	114.0	COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1XF98@135618|Methylococcales	135618|Methylococcales	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
CH3_k127_12521336_5	697282.Mettu_1391	4.125e-95	320.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1XECP@135618|Methylococcales	135618|Methylococcales	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
CH3_k127_12521336_3	686340.Metal_0761	8.941e-200	625.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1XESQ@135618|Methylococcales	135618|Methylococcales	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
CH3_k127_12521336_8	243233.MCA0099	4.648e-33	131.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1XFG3@135618|Methylococcales	135618|Methylococcales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
CH3_k127_12521336_2	697282.Mettu_1388	6.897e-247	769.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1XDYT@135618|Methylococcales	135618|Methylococcales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CH3_k127_12521336_1	686340.Metal_0758	5.332e-253	787.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1XE06@135618|Methylococcales	135618|Methylococcales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
CH3_k127_12521336_4	857087.Metme_4440	3.386e-156	502.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1XED6@135618|Methylococcales	135618|Methylococcales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CH3_k127_12521336_6	697282.Mettu_2364	2.797e-94	314.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1XEBX@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
CH3_k127_12521336_0	697282.Mettu_2365	7.204e-311	964.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1XEMK@135618|Methylococcales	135618|Methylococcales	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
CH3_k127_12521336_7	697282.Mettu_2366	2.464e-48	175.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1XEBH@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
CH3_k127_12556912_0	697282.Mettu_0509	6.885e-122	402.0	COG4585@1|root,COG4585@2|Bacteria,1RHF6@1224|Proteobacteria,1S8ER@1236|Gammaproteobacteria,1XEPJ@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor region	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,LapD_MoxY_N
CH3_k127_12556912_1	697282.Mettu_0508	1.956e-80	273.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,1XF2P@135618|Methylococcales	135618|Methylococcales	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CH3_k127_12556912_2	857087.Metme_3746	6.955e-54	193.0	COG4773@1|root,COG4773@2|Bacteria,1QVK7@1224|Proteobacteria,1T53A@1236|Gammaproteobacteria,1XDUB@135618|Methylococcales	135618|Methylococcales	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
CH3_k127_1263976_6	697282.Mettu_2298	2.973e-138	443.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XE14@135618|Methylococcales	135618|Methylococcales	M	Sporulation related domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	LysM,SPOR,YkuD
CH3_k127_1263976_11	686340.Metal_1385	4.668e-48	178.0	2C0PI@1|root,32VVI@2|Bacteria,1N1H7@1224|Proteobacteria,1T66V@1236|Gammaproteobacteria,1XFRH@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1263976_3	686340.Metal_1384	4.072e-225	702.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,1RSA3@1236|Gammaproteobacteria,1XEB5@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
CH3_k127_1263976_1	697282.Mettu_2552	1.895e-267	829.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1XDTU@135618|Methylococcales	135618|Methylococcales	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
CH3_k127_1263976_9	686340.Metal_2536	1.431e-70	244.0	COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1XF2J@135618|Methylococcales	135618|Methylococcales	S	SCP-2 sterol transfer family	-	-	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
CH3_k127_1263976_5	857087.Metme_0893	3.739e-141	451.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1XEV3@135618|Methylococcales	135618|Methylococcales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CH3_k127_1263976_10	857087.Metme_0892	1.034e-53	191.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1XFEV@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
CH3_k127_1263976_4	686340.Metal_2533	1.248e-223	699.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1XE7G@135618|Methylococcales	135618|Methylococcales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
CH3_k127_1263976_8	1116472.MGMO_175c00050	4.121e-93	308.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1XDWA@135618|Methylococcales	135618|Methylococcales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
CH3_k127_1263976_0	697282.Mettu_2572	0.0	1098.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1XE70@135618|Methylococcales	135618|Methylococcales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
CH3_k127_1263976_7	697282.Mettu_2573	2.022e-104	347.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1XEIJ@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
CH3_k127_1263976_12	1116472.MGMO_26c00250	1.017e-27	117.0	2AW4Y@1|root,31MZV@2|Bacteria,1QJRM@1224|Proteobacteria,1THSW@1236|Gammaproteobacteria,1XFKM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1263976_2	697282.Mettu_0678	7.704e-240	746.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1XDTH@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CH3_k127_135526_4	697282.Mettu_3094	6.612e-52	187.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1XFE1@135618|Methylococcales	135618|Methylococcales	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
CH3_k127_135526_3	697282.Mettu_3091	6.604e-87	291.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1XDW3@135618|Methylococcales	135618|Methylococcales	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
CH3_k127_135526_1	697282.Mettu_3089	1.292e-196	629.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1XDWV@135618|Methylococcales	135618|Methylococcales	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
CH3_k127_135526_6	1117314.PCIT_05764	6.527e-09	60.0	2DP8T@1|root,3311X@2|Bacteria,1NCQ9@1224|Proteobacteria,1SFHB@1236|Gammaproteobacteria,2Q3DV@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_135526_5	697282.Mettu_0760	5.918e-26	111.0	2B5JV@1|root,31YET@2|Bacteria,1QK4K@1224|Proteobacteria,1TI7N@1236|Gammaproteobacteria,1XGQ7@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_135526_0	697282.Mettu_0761	0.0	1172.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1XE41@135618|Methylococcales	135618|Methylococcales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
CH3_k127_135526_2	686340.Metal_2412	2.193e-139	447.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1XDN3@135618|Methylococcales	135618|Methylococcales	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CH3_k127_1361681_2	686340.Metal_2640	1.157e-59	207.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1XEGX@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
CH3_k127_1361681_0	686340.Metal_2639	6.148e-193	605.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1XDRT@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CH3_k127_1361681_1	686340.Metal_2638	1.183e-73	264.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XEBN@135618|Methylococcales	135618|Methylococcales	NU	COG3170 Tfp pilus assembly protein FimV	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	-
CH3_k127_1362163_0	857087.Metme_0488	2.604e-184	585.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1XE6M@135618|Methylococcales	135618|Methylococcales	S	PFAM Polyphosphate kinase 2	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
CH3_k127_1362163_2	686340.Metal_2030	4.419e-110	362.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,1XG60@135618|Methylococcales	135618|Methylococcales	C	C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1362163_6	697282.Mettu_4303	4.056e-33	131.0	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria,1XFKG@135618|Methylococcales	135618|Methylococcales	S	PFAM Sulphur oxidation protein SoxZ	soxZ	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
CH3_k127_1362163_5	686340.Metal_2032	7.74e-34	136.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S2ZH@1236|Gammaproteobacteria,1XFNB@135618|Methylococcales	135618|Methylococcales	S	Sulfur oxidation protein SoxY	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
CH3_k127_1362163_4	1116472.MGMO_174c00120	1.905e-40	155.0	COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria,1XGI2@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
CH3_k127_1362163_3	697282.Mettu_4305	5.186e-74	259.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,1XEXZ@135618|Methylococcales	135618|Methylococcales	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
CH3_k127_1362163_1	697282.Mettu_4306	1.275e-110	362.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1XEFH@135618|Methylococcales	135618|Methylococcales	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
CH3_k127_1376924_4	697282.Mettu_1080	3.909e-46	172.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,1RNUY@1236|Gammaproteobacteria,1XETB@135618|Methylococcales	135618|Methylococcales	F	Belongs to the bacterial glucokinase family	-	-	-	-	-	-	-	-	-	-	-	-	Glucokinase
CH3_k127_1376924_3	686340.Metal_2669	5.305e-54	194.0	COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,1XFBS@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function, DUF	-	-	-	-	-	-	-	-	-	-	-	-	DUF411
CH3_k127_1376924_2	675806.VII_003360	1.321e-56	200.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1XWZM@135623|Vibrionales	135623|Vibrionales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CH3_k127_1376924_0	697282.Mettu_1082	1.162e-191	602.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1XDUA@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CH3_k127_1376924_1	697282.Mettu_1084	2.342e-74	252.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1XDU1@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
CH3_k127_138019_1	1120999.JONM01000009_gene281	8.865e-56	206.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2VNED@28216|Betaproteobacteria,2KPZ4@206351|Neisseriales	206351|Neisseriales	L	DNA polymerase III, delta	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
CH3_k127_138019_0	1485544.JQKP01000013_gene1816	5.585e-101	338.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,44V7Z@713636|Nitrosomonadales	28216|Betaproteobacteria	L	TatD related DNase	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CH3_k127_138019_2	497321.C664_01740	5.008e-34	138.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2VPIV@28216|Betaproteobacteria,2KWJN@206389|Rhodocyclales	206389|Rhodocyclales	S	ankyrin repeat	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
CH3_k127_1395794_8	765913.ThidrDRAFT_0914	2.872e-38	158.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM Cytochrome c-type biogenesis protein CcmI	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
CH3_k127_1395794_7	911239.CF149_22123	2.131e-40	160.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	subunit of a heme lyase	ccmH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
CH3_k127_1395794_5	1122599.AUGR01000008_gene2525	3.966e-55	199.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,1XK8W@135619|Oceanospirillales	135619|Oceanospirillales	CO	Thiol disulfide interchange protein	ccmG	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	Redoxin
CH3_k127_1395794_0	1278309.KB907107_gene1689	1.265e-261	822.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1XHYK@135619|Oceanospirillales	135619|Oceanospirillales	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
CH3_k127_1395794_6	1121935.AQXX01000142_gene2171	2.128e-50	183.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria,1XJZE@135619|Oceanospirillales	135619|Oceanospirillales	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
CH3_k127_1395794_9	1388763.O165_015280	1.217e-08	62.0	COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,1YZ8I@136845|Pseudomonas putida group	1236|Gammaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmD	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735	CcmD
CH3_k127_1395794_1	95619.PM1_0209945	6.344e-114	372.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Cytochrom_C_asm
CH3_k127_1395794_2	1122599.AUGR01000008_gene2521	8.56e-79	271.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1XIZ7@135619|Oceanospirillales	135619|Oceanospirillales	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
CH3_k127_1395794_3	1042375.AFPL01000017_gene365	1.932e-78	267.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,466VK@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479	ABC_tran
CH3_k127_1395794_4	1163617.SCD_n02070	9.281e-71	247.0	COG0500@1|root,COG2226@2|Bacteria,1NRR4@1224|Proteobacteria,2W05F@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CH3_k127_1395794_10	582744.Msip34_0215	6.579e-08	54.0	293CN@1|root,2Z8R1@2|Bacteria,1R8CI@1224|Proteobacteria,2VZKD@28216|Betaproteobacteria,2KKCK@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1401002_0	1266925.JHVX01000006_gene2114	1.706e-65	243.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2W9RH@28216|Betaproteobacteria,3744M@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CH3_k127_1427076_8	697282.Mettu_0718	5.433e-55	199.0	2E7NN@1|root,3324C@2|Bacteria,1NA2Z@1224|Proteobacteria,1SVUS@1236|Gammaproteobacteria,1XFCU@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1427076_13	686340.Metal_1413	1.089e-07	61.0	2B1M3@1|root,31U2J@2|Bacteria,1QRW4@1224|Proteobacteria,1THVR@1236|Gammaproteobacteria,1XFUM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1427076_0	697282.Mettu_2585	5.305e-226	709.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1XDY2@135618|Methylococcales	135618|Methylococcales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CH3_k127_1427076_3	1049564.TevJSym_af00130	1.037e-136	441.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1J5VE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	DnaJ-class molecular chaperone	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
CH3_k127_1427076_10	365044.Pnap_2221	4.652e-29	119.0	COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria,2VVPZ@28216|Betaproteobacteria	28216|Betaproteobacteria	K	MerR HTH family regulatory protein	-	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
CH3_k127_1427076_12	1249627.D779_3899	7.684e-14	73.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria,1WYAU@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
CH3_k127_1427076_9	349521.HCH_01554	9.527e-48	177.0	COG3122@1|root,COG3122@2|Bacteria,1N15V@1224|Proteobacteria,1S5V0@1236|Gammaproteobacteria,1XKK5@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K09912	-	-	-	-	ko00000	-	-	-	DUF2058
CH3_k127_1427076_6	697282.Mettu_3210	5.363e-57	204.0	2AUFG@1|root,31K3K@2|Bacteria,1QHXC@1224|Proteobacteria,1TFNZ@1236|Gammaproteobacteria,1XF8U@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1427076_4	697282.Mettu_2838	3.472e-135	436.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1XECY@135618|Methylococcales	135618|Methylococcales	M	UTP-glucose-1-phosphate uridylyltransferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CH3_k127_1427076_1	857087.Metme_2452	1.145e-154	495.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1XEJ2@135618|Methylococcales	135618|Methylococcales	M	epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CH3_k127_1427076_5	857087.Metme_1504	2.065e-111	371.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1XE7Y@135618|Methylococcales	135618|Methylococcales	P	Transporter associated domain	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
CH3_k127_1427076_7	697282.Mettu_0680	1.32e-55	198.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,1XFBM@135618|Methylococcales	135618|Methylococcales	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
CH3_k127_1427076_2	243233.MCA1458	3.861e-148	475.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1XE38@135618|Methylococcales	135618|Methylococcales	T	PFAM PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
CH3_k127_1427076_11	857087.Metme_1501	8.635e-23	98.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1XDTH@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CH3_k127_1430340_1	631362.Thi970DRAFT_04186	6.104e-205	643.0	COG1449@1|root,COG1449@2|Bacteria,1R18I@1224|Proteobacteria,1SGAD@1236|Gammaproteobacteria,1X04T@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
CH3_k127_1430340_6	1049564.TevJSym_aa02400	2.464e-52	192.0	COG1394@1|root,COG1394@2|Bacteria,1RJCN@1224|Proteobacteria,1S7QV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
CH3_k127_1430340_2	857087.Metme_2362	4.95e-191	614.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RY40@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
CH3_k127_1430340_4	857087.Metme_2363	8.597e-71	243.0	COG0636@1|root,COG0636@2|Bacteria,1RB4B@1224|Proteobacteria,1S2I4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP synthase, subunit	atpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
CH3_k127_1430340_3	857087.Metme_2364	5.247e-73	252.0	COG1390@1|root,COG1390@2|Bacteria,1MYFC@1224|Proteobacteria,1S1YK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
CH3_k127_1430340_5	857087.Metme_2365	1.102e-65	231.0	28P4X@1|root,2ZC02@2|Bacteria,1RB0B@1224|Proteobacteria,1S2S5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2764
CH3_k127_1430340_0	857087.Metme_2366	2.255e-287	892.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
CH3_k127_1431295_0	1116472.MGMO_10c00050	0.0	1189.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XDSC@135618|Methylococcales	135618|Methylococcales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
CH3_k127_1431295_1	1116472.MGMO_10c00070	3.576e-42	158.0	29FX1@1|root,34453@2|Bacteria,1P3CX@1224|Proteobacteria,1SVJS@1236|Gammaproteobacteria,1XGJE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1431295_2	1122165.AUHS01000012_gene2813	5.639e-15	81.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1JCMG@118969|Legionellales	118969|Legionellales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CH3_k127_1433219_14	697282.Mettu_1136	4.453e-29	119.0	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1XFGK@135618|Methylococcales	135618|Methylococcales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
CH3_k127_1433219_10	697282.Mettu_1135	7.003e-90	301.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1XDP0@135618|Methylococcales	135618|Methylococcales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
CH3_k127_1433219_4	697282.Mettu_1134	2.525e-140	454.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1XE7Q@135618|Methylococcales	135618|Methylococcales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
CH3_k127_1433219_13	243233.MCA1461	2.571e-44	170.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1XF06@135618|Methylococcales	135618|Methylococcales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
CH3_k127_1433219_6	697282.Mettu_1132	3.749e-113	372.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1XE0P@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
CH3_k127_1433219_11	697282.Mettu_1131	5.842e-86	290.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,1SZE9@1236|Gammaproteobacteria,1XDM8@135618|Methylococcales	135618|Methylococcales	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
CH3_k127_1433219_3	697282.Mettu_0998	9.208e-149	480.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1XDRN@135618|Methylococcales	135618|Methylococcales	P	PFAM NnrS	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
CH3_k127_1433219_0	686340.Metal_3483	4.72e-227	707.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1XE3G@135618|Methylococcales	135618|Methylococcales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
CH3_k127_1433219_7	686340.Metal_3484	2.21e-93	312.0	COG1409@1|root,COG1409@2|Bacteria,1R4AZ@1224|Proteobacteria,1S5VS@1236|Gammaproteobacteria,1XEX9@135618|Methylococcales	135618|Methylococcales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CH3_k127_1433219_12	697282.Mettu_0907	1.158e-67	233.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1XF48@135618|Methylococcales	135618|Methylococcales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
CH3_k127_1433219_2	697282.Mettu_2331	5.722e-157	511.0	COG3182@1|root,COG3182@2|Bacteria,1MXGY@1224|Proteobacteria,1RYMS@1236|Gammaproteobacteria,1XE4W@135618|Methylococcales	135618|Methylococcales	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
CH3_k127_1433219_8	686340.Metal_0748	1.512e-91	306.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,1XDNI@135618|Methylococcales	135618|Methylococcales	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
CH3_k127_1433219_9	686340.Metal_0749	1.715e-90	305.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XE78@135618|Methylococcales	135618|Methylococcales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
CH3_k127_1433219_1	857087.Metme_3027	5.247e-175	552.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1XDTQ@135618|Methylococcales	135618|Methylococcales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CH3_k127_1433219_5	697282.Mettu_3450	9.304e-117	379.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1XE4U@135618|Methylococcales	135618|Methylococcales	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	-
CH3_k127_1490853_2	686340.Metal_3634	4.27e-42	160.0	COG2067@1|root,COG2067@2|Bacteria,1NQ4A@1224|Proteobacteria,1RYKE@1236|Gammaproteobacteria,1XEJE@135618|Methylococcales	135618|Methylococcales	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
CH3_k127_1490853_3	686340.Metal_3634	1.319e-18	87.0	COG2067@1|root,COG2067@2|Bacteria,1NQ4A@1224|Proteobacteria,1RYKE@1236|Gammaproteobacteria,1XEJE@135618|Methylococcales	135618|Methylococcales	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
CH3_k127_1490853_0	697282.Mettu_1182	3.327e-148	478.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1XDQ5@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4
CH3_k127_1490853_1	857087.Metme_0879	5.039e-52	187.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XDX4@135618|Methylococcales	135618|Methylococcales	T	Nitrogen regulation	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CH3_k127_1493239_3	686340.Metal_1397	2.786e-50	182.0	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1XENM@135618|Methylococcales	135618|Methylococcales	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxH	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos
CH3_k127_1493239_1	857087.Metme_2666	1.094e-97	325.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1XE7U@135618|Methylococcales	135618|Methylococcales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
CH3_k127_1493239_6	697282.Mettu_1037	1.795e-26	109.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,1SCFF@1236|Gammaproteobacteria,1XFSG@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
CH3_k127_1493239_0	697282.Mettu_0990	4.017e-126	411.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1XETF@135618|Methylococcales	135618|Methylococcales	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
CH3_k127_1493239_5	1116472.MGMO_42c00040	1.441e-39	151.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,1XFB8@135618|Methylococcales	135618|Methylococcales	U	Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
CH3_k127_1493239_2	697282.Mettu_0988	2.45e-86	292.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1XF00@135618|Methylococcales	135618|Methylococcales	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CH3_k127_1493239_4	697282.Mettu_0987	1.163e-44	166.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1XDJR@135618|Methylococcales	135618|Methylococcales	EGP	Nucleoside H+ symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
CH3_k127_1509072_1	1123401.JHYQ01000025_gene3302	9.174e-49	179.0	COG2050@1|root,COG2050@2|Bacteria,1RH0Z@1224|Proteobacteria,1S5W6@1236|Gammaproteobacteria,461FH@72273|Thiotrichales	72273|Thiotrichales	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
CH3_k127_1509072_0	697282.Mettu_1608	0.0	1083.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1XEE4@135618|Methylococcales	135618|Methylococcales	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
CH3_k127_155192_2	768671.ThimaDRAFT_1459	2.191e-11	70.0	2CFV2@1|root,32UMX@2|Bacteria,1N3YD@1224|Proteobacteria,1SABG@1236|Gammaproteobacteria,1WZ2C@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_155192_1	697282.Mettu_0389	1.119e-92	307.0	COG2236@1|root,COG2236@2|Bacteria,1RKB0@1224|Proteobacteria,1S7J1@1236|Gammaproteobacteria,1XFMX@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
CH3_k127_155192_0	243233.MCA0129	9.406e-131	425.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1XEB2@135618|Methylococcales	135618|Methylococcales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
CH3_k127_1571367_0	857087.Metme_4108	7.345e-145	473.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XE9U@135618|Methylococcales	135618|Methylococcales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CH3_k127_1571367_1	686340.Metal_3852	4.093e-59	206.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XEHC@135618|Methylococcales	135618|Methylococcales	P	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hydrolase
CH3_k127_1604034_1	686340.Metal_1990	1.595e-59	216.0	COG5544@1|root,COG5544@2|Bacteria,1QU58@1224|Proteobacteria,1RYPH@1236|Gammaproteobacteria,1XDSJ@135618|Methylococcales	135618|Methylococcales	S	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1604034_0	697282.Mettu_0796	2.379e-199	630.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1XE6P@135618|Methylococcales	135618|Methylococcales	FP	Belongs to the GppA Ppx family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
CH3_k127_1604645_2	857087.Metme_3280	3.574e-100	329.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1XDV5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CH3_k127_1604645_3	472759.Nhal_1738	6.332e-37	141.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1604645_4	472759.Nhal_1737	5.141e-28	114.0	COG2442@1|root,COG2442@2|Bacteria,1N8Z1@1224|Proteobacteria,1SC0G@1236|Gammaproteobacteria,1WZ65@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
CH3_k127_1604645_1	697282.Mettu_2581	7.622e-115	376.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,1RSP8@1236|Gammaproteobacteria,1XG94@135618|Methylococcales	135618|Methylococcales	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
CH3_k127_1604645_0	686340.Metal_0403	2.743e-176	557.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1XDX7@135618|Methylococcales	135618|Methylococcales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CH3_k127_1604645_5	686340.Metal_0168	6.612e-17	86.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1XG3Q@135618|Methylococcales	135618|Methylococcales	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
CH3_k127_163969_0	857087.Metme_0611	2.535e-163	517.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1XETA@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
CH3_k127_163969_1	857087.Metme_0610	1.13e-55	199.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1XFN7@135618|Methylococcales	135618|Methylococcales	S	PFAM Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
CH3_k127_163969_2	697282.Mettu_0893	7.206e-13	70.0	COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1XFK1@135618|Methylococcales	135618|Methylococcales	S	Sporulation related domain	-	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
CH3_k127_1741908_2	224308.BSU38910	1.04e-10	68.0	COG2197@1|root,COG2197@2|Bacteria,1V30W@1239|Firmicutes,4HT1P@91061|Bacilli,1ZGDR@1386|Bacillus	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
CH3_k127_1741908_3	765914.ThisiDRAFT_0619	1.901e-07	54.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1,Y2_Tnp
CH3_k127_1741908_0	686340.Metal_3874	5.127e-233	734.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,1RPQA@1236|Gammaproteobacteria,1XEC2@135618|Methylococcales	135618|Methylococcales	S	ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2
CH3_k127_1741908_1	663610.JQKO01000004_gene2745	2.77e-172	546.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3NC0H@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
CH3_k127_1746553_0	686340.Metal_1824	8.96e-165	526.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XEX2@135618|Methylococcales	135618|Methylococcales	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
CH3_k127_1746553_1	686340.Metal_1823	2.708e-146	473.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1XEP7@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
CH3_k127_1746553_4	686340.Metal_2731	6.929e-55	195.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S82I@1236|Gammaproteobacteria,1XF73@135618|Methylococcales	135618|Methylococcales	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
CH3_k127_1746553_2	857087.Metme_4601	1.039e-100	332.0	COG0811@1|root,COG0811@2|Bacteria,1RA2U@1224|Proteobacteria,1RPZ5@1236|Gammaproteobacteria,1XE5S@135618|Methylococcales	135618|Methylococcales	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CH3_k127_1746553_3	857087.Metme_2867	9.362e-65	230.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1SCVJ@1236|Gammaproteobacteria,1XF4A@135618|Methylococcales	135618|Methylococcales	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
CH3_k127_1771599_6	1116472.MGMO_85c00180	3.502e-14	72.0	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,1XEFQ@135618|Methylococcales	135618|Methylococcales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CH3_k127_1771599_0	946483.Cenrod_2337	7.033e-152	502.0	COG0784@1|root,COG2198@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2200@2|Bacteria,1NC9X@1224|Proteobacteria,2WGSU@28216|Betaproteobacteria,4ADPW@80864|Comamonadaceae	28216|Betaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	EAL,Response_reg
CH3_k127_1771599_5	864051.BurJ1DRAFT_4640	5.073e-47	175.0	COG0745@1|root,COG0745@2|Bacteria,1QWG0@1224|Proteobacteria,2WGYI@28216|Betaproteobacteria,1KPDN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KT	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
CH3_k127_1771599_4	697282.Mettu_2132	9.375e-57	199.0	COG2346@1|root,COG2346@2|Bacteria,1QBDE@1224|Proteobacteria,1S9FC@1236|Gammaproteobacteria,1XFBT@135618|Methylococcales	135618|Methylococcales	C	Group 1 truncated hemoglobin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
CH3_k127_1771599_3	686340.Metal_1438	1.611e-66	232.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1XEYD@135618|Methylococcales	135618|Methylococcales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CH3_k127_1771599_2	697282.Mettu_2464	3.113e-69	237.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1XF3V@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
CH3_k127_1771599_1	379731.PST_2952	2.525e-75	273.0	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,1SYEH@1236|Gammaproteobacteria,1Z0RY@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	KLT	COG0515 Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	Pkinase
CH3_k127_1771786_1	243233.MCA0593	3.75e-115	380.0	COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,1XENA@135618|Methylococcales	135618|Methylococcales	KLT	kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2,Pkinase
CH3_k127_1771786_0	243233.MCA0594	5.334e-225	704.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1XE4N@135618|Methylococcales	135618|Methylococcales	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
CH3_k127_1771786_2	1116472.MGMO_85c00180	9.099e-14	71.0	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,1XEFQ@135618|Methylococcales	135618|Methylococcales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CH3_k127_1813866_2	857087.Metme_3144	1.687e-71	244.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,1XDM2@135618|Methylococcales	135618|Methylococcales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
CH3_k127_1813866_0	857087.Metme_3143	5.097e-133	427.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1XG96@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CH3_k127_1813866_1	857087.Metme_3142	1.691e-106	356.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,1S6SW@1236|Gammaproteobacteria,1XGZV@135618|Methylococcales	135618|Methylococcales	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
CH3_k127_1813866_3	857087.Metme_3141	1.938e-51	188.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1SHZZ@1236|Gammaproteobacteria,1XF9Y@135618|Methylococcales	135618|Methylococcales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
CH3_k127_1837888_4	1283300.ATXB01000002_gene3007	1.982e-16	81.0	2AUTZ@1|root,31KH1@2|Bacteria,1QIC9@1224|Proteobacteria,1TG6N@1236|Gammaproteobacteria,1XFT8@135618|Methylococcales	135618|Methylococcales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
CH3_k127_1837888_0	1116472.MGMO_66c00630	5.118e-63	218.0	COG0720@1|root,COG0720@2|Bacteria,1RKBW@1224|Proteobacteria,1S7FX@1236|Gammaproteobacteria,1XF2V@135618|Methylococcales	135618|Methylococcales	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
CH3_k127_1837888_3	697282.Mettu_0300	1.578e-43	163.0	COG3151@1|root,COG3151@2|Bacteria,1QJNF@1224|Proteobacteria,1THP7@1236|Gammaproteobacteria,1XF5H@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1249)	-	-	-	ko:K09920	-	-	-	-	ko00000	-	-	-	DUF1249
CH3_k127_1837888_2	1134474.O59_000012	5.987e-50	181.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1FIBM@10|Cellvibrio	1236|Gammaproteobacteria	M	Large-conductance mechanosensitive channel, MscL	mscL	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
CH3_k127_1837888_1	1163617.SCD_n00041	1.488e-61	221.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2VIBH@28216|Betaproteobacteria	28216|Betaproteobacteria	U	UPF0056 inner membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
CH3_k127_1837888_5	1304877.KI519399_gene5977	8.257e-08	58.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,3JUVJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	modA	GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
CH3_k127_1840533_2	768671.ThimaDRAFT_0863	1.418e-14	73.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,1WVZE@135613|Chromatiales	135613|Chromatiales	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
CH3_k127_1840533_0	765911.Thivi_3657	0.0	1211.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WVYX@135613|Chromatiales	1236|Gammaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CH3_k127_1840533_1	1116472.MGMO_49c00040	9.179e-104	340.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,1SAR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoglycerate mutase	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
CH3_k127_1860656_0	697282.Mettu_1617	2.056e-165	527.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1XDWX@135618|Methylococcales	135618|Methylococcales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
CH3_k127_1860656_7	857087.Metme_0755	1.243e-51	186.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1XF5X@135618|Methylococcales	135618|Methylococcales	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
CH3_k127_1860656_8	1116472.MGMO_124c00130	6.659e-37	139.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,1XFID@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
CH3_k127_1860656_1	697282.Mettu_1614	1.957e-163	519.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1XDPB@135618|Methylococcales	135618|Methylococcales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CH3_k127_1860656_3	686340.Metal_3435	2.069e-75	258.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1XEXT@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
CH3_k127_1860656_6	1116472.MGMO_124c00170	3.307e-52	186.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1XFDQ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
CH3_k127_1860656_5	697282.Mettu_1610	3.948e-69	237.0	COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,1XF75@135618|Methylococcales	135618|Methylococcales	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
CH3_k127_1860656_2	697282.Mettu_2628	1.017e-127	416.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1XDJ4@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
CH3_k127_1860656_9	697282.Mettu_2627	1.3e-24	107.0	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1XFS7@135618|Methylococcales	135618|Methylococcales	K	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters	-	-	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
CH3_k127_1860656_4	857087.Metme_1471	3.295e-71	243.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1XDUC@135618|Methylococcales	135618|Methylococcales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CH3_k127_1878995_4	243233.MCA2148	3.358e-29	117.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XENK@135618|Methylococcales	135618|Methylococcales	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CH3_k127_1878995_3	686340.Metal_0842	2.161e-57	207.0	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,1SCGA@1236|Gammaproteobacteria,1XFGV@135618|Methylococcales	135618|Methylococcales	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CH3_k127_1878995_2	686340.Metal_3078	1.324e-69	246.0	COG1073@1|root,COG1073@2|Bacteria,1R8S6@1224|Proteobacteria,1S4WS@1236|Gammaproteobacteria,1XGDM@135618|Methylococcales	135618|Methylococcales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1878995_0	697282.Mettu_0636	1.233e-108	359.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,1XEUS@135618|Methylococcales	135618|Methylococcales	E	Pyridoxal-phosphate dependent enzyme	-	-	3.5.99.7	ko:K01505	ko00270,map00270	-	R00997	RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
CH3_k127_1878995_1	1116472.MGMO_8c00340	5.403e-71	246.0	COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria,1S423@1236|Gammaproteobacteria,1XFA5@135618|Methylococcales	135618|Methylococcales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
CH3_k127_1878995_5	697282.Mettu_0637	2.024e-28	116.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1XEEE@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
CH3_k127_1898191_6	243233.MCA1764	4.41e-82	282.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,1RYIX@1236|Gammaproteobacteria,1XEXF@135618|Methylococcales	135618|Methylococcales	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CH3_k127_1898191_2	1116472.MGMO_125c00060	6.033e-176	562.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,1RQGM@1236|Gammaproteobacteria,1XE10@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
CH3_k127_1898191_8	1121939.L861_23695	1.164e-06	53.0	COG3630@1|root,COG3630@2|Bacteria,1NHYS@1224|Proteobacteria,1SGS8@1236|Gammaproteobacteria,1XM8S@135619|Oceanospirillales	135619|Oceanospirillales	C	Lyase and sodium transporter	oadG	-	4.1.1.3	ko:K01573	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_gamma
CH3_k127_1898191_0	686340.Metal_1995	1.125e-267	837.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1XEWN@135618|Methylococcales	135618|Methylococcales	CI	Oxaloacetate decarboxylase, alpha subunit	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
CH3_k127_1898191_1	697282.Mettu_2617	1.523e-197	623.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,1XE74@135618|Methylococcales	135618|Methylococcales	C	decarboxylase, beta subunit	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
CH3_k127_1898191_5	1117958.PE143B_0101130	1.45e-135	461.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	morA	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,dCache_2
CH3_k127_1898191_7	582744.Msip34_2415	2.68e-80	272.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,2W271@28216|Betaproteobacteria,2KMMP@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CH3_k127_1898191_4	697282.Mettu_2902	4.609e-139	451.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1XDS3@135618|Methylococcales	135618|Methylococcales	S	AI-2E family transporter	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
CH3_k127_1898191_3	243233.MCA1634	2.999e-161	516.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1XEDA@135618|Methylococcales	135618|Methylococcales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
CH3_k127_1918268_3	1116472.MGMO_41c00140	9.361e-93	308.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1XEE2@135618|Methylococcales	135618|Methylococcales	NU	TIGRFAM Pilus retraction protein PilT	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CH3_k127_1918268_1	686340.Metal_3714	2.394e-198	621.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1XDNT@135618|Methylococcales	135618|Methylococcales	NU	TIGRFAM Pilus retraction protein PilT	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CH3_k127_1918268_2	697282.Mettu_1685	2.041e-94	314.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,1XEED@135618|Methylococcales	135618|Methylococcales	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
CH3_k127_1918268_4	1116472.MGMO_112c00090	3.386e-28	116.0	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1XFG1@135618|Methylococcales	135618|Methylococcales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
CH3_k127_1918268_0	697282.Mettu_1734	6.978e-253	787.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1XDIR@135618|Methylococcales	135618|Methylococcales	O	Mg chelatase-related protein	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
CH3_k127_1926996_0	857087.Metme_3822	0.0	1260.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1XE7C@135618|Methylococcales	135618|Methylococcales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CH3_k127_1926996_4	857087.Metme_3821	8.574e-69	234.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,1S3WB@1236|Gammaproteobacteria,1XF01@135618|Methylococcales	135618|Methylococcales	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
CH3_k127_1926996_3	686340.Metal_3317	2.666e-78	263.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1XENW@135618|Methylococcales	135618|Methylococcales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
CH3_k127_1926996_1	686340.Metal_3316	0.0	1236.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XDNZ@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CH3_k127_1926996_2	857087.Metme_3818	2.575e-91	301.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1XEWB@135618|Methylococcales	135618|Methylococcales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CH3_k127_1950728_1	686340.Metal_3458	7.444e-81	269.0	COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,1S6QN@1236|Gammaproteobacteria,1XF13@135618|Methylococcales	135618|Methylococcales	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
CH3_k127_1950728_0	686340.Metal_3952	1.459e-186	589.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria,1XEQB@135618|Methylococcales	135618|Methylococcales	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CH3_k127_1950728_4	686340.Metal_2577	0.0005692	43.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1XE2N@135618|Methylococcales	135618|Methylococcales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
CH3_k127_1950728_2	105559.Nwat_2538	4.417e-77	284.0	COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,1WY6N@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_1990809_7	697282.Mettu_3553	1.394e-14	76.0	COG0560@1|root,COG0560@2|Bacteria,1PIND@1224|Proteobacteria,1S9GK@1236|Gammaproteobacteria,1XEK5@135618|Methylococcales	135618|Methylococcales	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
CH3_k127_1990809_1	697282.Mettu_3552	5.924e-117	380.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1XDV4@135618|Methylococcales	135618|Methylococcales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
CH3_k127_1990809_4	857087.Metme_1487	1.826e-68	235.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1XF1A@135618|Methylococcales	135618|Methylococcales	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
CH3_k127_1990809_3	686340.Metal_2813	3.375e-83	282.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1XEQU@135618|Methylococcales	135618|Methylococcales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
CH3_k127_1990809_0	686340.Metal_2814	1.749e-176	559.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1XDQ4@135618|Methylococcales	135618|Methylococcales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
CH3_k127_1990809_5	686340.Metal_2815	1.658e-45	171.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1XFE7@135618|Methylococcales	135618|Methylococcales	S	Tol-Pal system-associated acyl-CoA thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
CH3_k127_1990809_2	857087.Metme_1491	6.553e-107	349.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1XDWZ@135618|Methylococcales	135618|Methylococcales	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
CH3_k127_1990809_6	243233.MCA1227	3.093e-44	165.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1XFHR@135618|Methylococcales	135618|Methylococcales	U	PFAM Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
CH3_k127_201356_1	1121035.AUCH01000007_gene585	2.55e-83	282.0	COG0542@1|root,COG0542@2|Bacteria,1MWQQ@1224|Proteobacteria,2VH2V@28216|Betaproteobacteria,2KVXD@206389|Rhodocyclales	206389|Rhodocyclales	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
CH3_k127_201356_4	1415778.JQMM01000001_gene2177	8.817e-26	109.0	2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria,1SCI0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
CH3_k127_201356_0	697282.Mettu_0381	8.113e-91	303.0	COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,1T170@1236|Gammaproteobacteria,1XEY5@135618|Methylococcales	135618|Methylococcales	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
CH3_k127_201356_3	697282.Mettu_0380	5.871e-35	135.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,1SA80@1236|Gammaproteobacteria,1XFH6@135618|Methylococcales	135618|Methylococcales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
CH3_k127_201356_2	1415778.JQMM01000001_gene2180	4.486e-35	139.0	COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria,1S4NA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
CH3_k127_20499_1	697282.Mettu_3595	4.825e-67	229.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1XEPE@135618|Methylococcales	135618|Methylococcales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
CH3_k127_20499_2	686340.Metal_1089	4.847e-65	227.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1XF8S@135618|Methylococcales	135618|Methylococcales	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CH3_k127_20499_0	857087.Metme_0783	7.276e-253	785.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1XDP7@135618|Methylococcales	135618|Methylococcales	F	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CH3_k127_206762_3	1122164.JHWF01000001_gene2013	9.778e-21	94.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1JCXF@118969|Legionellales	118969|Legionellales	S	Serine aminopeptidase, S33	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
CH3_k127_206762_1	243233.MCA1012	2.22e-100	338.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1XECS@135618|Methylococcales	135618|Methylococcales	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934,FA_hydroxylase
CH3_k127_206762_0	686340.Metal_3469	2.771e-117	386.0	COG0524@1|root,COG0524@2|Bacteria,1MWX4@1224|Proteobacteria,1RU49@1236|Gammaproteobacteria,1XETS@135618|Methylococcales	135618|Methylococcales	G	Belongs to the carbohydrate kinase PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CH3_k127_206762_2	697282.Mettu_1661	3.972e-27	112.0	COG3313@1|root,COG3313@2|Bacteria,1QIZR@1224|Proteobacteria,1TGWK@1236|Gammaproteobacteria,1XGUB@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1289)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1289
CH3_k127_2106022_11	686340.Metal_0118	3.032e-48	179.0	2C5QF@1|root,331W9@2|Bacteria,1N7AE@1224|Proteobacteria,1SCH2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4381)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4381
CH3_k127_2106022_6	697282.Mettu_1931	1.223e-107	358.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1XEJ0@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CH3_k127_2106022_3	686340.Metal_0116	2.428e-162	516.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1XESU@135618|Methylococcales	135618|Methylococcales	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CH3_k127_2106022_13	686340.Metal_1632	1.114e-11	69.0	2AWKC@1|root,31NH3@2|Bacteria,1QK7Y@1224|Proteobacteria,1TIB8@1236|Gammaproteobacteria,1XGWS@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_2106022_14	1182590.BN5_03251	4.66e-11	65.0	COG1487@1|root,COG1487@2|Bacteria,1MZQC@1224|Proteobacteria,1SAJG@1236|Gammaproteobacteria,1YKEJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
CH3_k127_2106022_12	686340.Metal_2785	2.386e-47	172.0	COG0662@1|root,COG0662@2|Bacteria,1N00P@1224|Proteobacteria,1S759@1236|Gammaproteobacteria,1XFIZ@135618|Methylococcales	135618|Methylococcales	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CH3_k127_2106022_9	643562.Daes_2690	8.723e-81	279.0	COG2173@1|root,COG2173@2|Bacteria,1RENK@1224|Proteobacteria,42RT1@68525|delta/epsilon subdivisions,2X5CH@28221|Deltaproteobacteria,2MGPF@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
CH3_k127_2106022_1	1116472.MGMO_115c00010	9.237e-196	619.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1XEM7@135618|Methylococcales	135618|Methylococcales	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
CH3_k127_2106022_5	686340.Metal_0113	1.207e-121	396.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1XDTD@135618|Methylococcales	135618|Methylococcales	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CH3_k127_2106022_0	697282.Mettu_3282	1.704e-257	798.0	COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XEVC@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4478)	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DUF3412,DUF4478,Lysine_decarbox
CH3_k127_2106022_10	686340.Metal_0734	3.376e-68	238.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1XEYZ@135618|Methylococcales	135618|Methylococcales	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
CH3_k127_2106022_2	1198232.CYCME_2488	4.459e-189	611.0	COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,1RXXZ@1236|Gammaproteobacteria,46045@72273|Thiotrichales	72273|Thiotrichales	O	Cytochrome c-type biogenesis protein Ccs1 ResB	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
CH3_k127_2106022_7	857087.Metme_0151	1.54e-85	291.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1XEW3@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CH3_k127_2106022_8	697282.Mettu_2184	2.769e-85	287.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1XE8S@135618|Methylococcales	135618|Methylococcales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
CH3_k127_2106022_4	686340.Metal_1007	1.112e-144	464.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1XDNB@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
CH3_k127_2110865_3	686340.Metal_0768	9.019e-87	291.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1XE3C@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
CH3_k127_2110865_4	1198232.CYCME_0705	3.008e-50	186.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,4610F@72273|Thiotrichales	72273|Thiotrichales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
CH3_k127_2110865_2	857087.Metme_1057	1.039e-120	397.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1XDZY@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lytic murein transglycosylase B	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
CH3_k127_2110865_1	697282.Mettu_1394	6.434e-181	572.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1XEKN@135618|Methylococcales	135618|Methylococcales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
CH3_k127_2110865_0	697282.Mettu_1393	2.243e-237	744.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1XDPF@135618|Methylococcales	135618|Methylococcales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
CH3_k127_2237506_0	497964.CfE428DRAFT_2340	2.065e-186	596.0	COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_22403_0	1283300.ATXB01000002_gene2539	9.047e-136	448.0	COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,1RRH5@1236|Gammaproteobacteria,1XE6U@135618|Methylococcales	135618|Methylococcales	S	Phage terminase large subunit (GpA)	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_GpA
CH3_k127_2289927_0	686340.Metal_1998	1.484e-124	411.0	COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1RENP@1224|Proteobacteria,1S4IW@1236|Gammaproteobacteria,1XDQI@135618|Methylococcales	135618|Methylococcales	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
CH3_k127_2289927_1	1042375.AFPL01000026_gene3750	5.669e-25	104.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,4642I@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSDY_1059.SDY_2368	Seryl_tRNA_N,tRNA-synt_2b
CH3_k127_2293051_4	472759.Nhal_0733	9.522e-43	158.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,1RQIA@1236|Gammaproteobacteria,1WWVB@135613|Chromatiales	135613|Chromatiales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CH3_k127_2293051_1	686340.Metal_1032	7.275e-121	408.0	COG1819@1|root,COG1819@2|Bacteria,1QVV0@1224|Proteobacteria,1RQBP@1236|Gammaproteobacteria,1XDNU@135618|Methylococcales	135618|Methylococcales	CG	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_3
CH3_k127_2293051_3	697282.Mettu_4151	2.922e-64	225.0	COG0671@1|root,COG0671@2|Bacteria,1RJ1T@1224|Proteobacteria,1SAU1@1236|Gammaproteobacteria,1XF8J@135618|Methylococcales	135618|Methylococcales	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
CH3_k127_2293051_0	697282.Mettu_4120	2.371e-302	930.0	COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1XENX@135618|Methylococcales	135618|Methylococcales	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
CH3_k127_2293051_2	1116472.MGMO_84c00070	2.378e-79	272.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales	135618|Methylococcales	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
CH3_k127_2293051_6	338966.Ppro_1355	4.783e-16	83.0	COG4453@1|root,COG4453@2|Bacteria,1N7K8@1224|Proteobacteria,432TR@68525|delta/epsilon subdivisions,2WXDZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1778)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1778
CH3_k127_2293051_5	697282.Mettu_2908	5.845e-40	152.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1XEMN@135618|Methylococcales	135618|Methylococcales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CH3_k127_2295001_1	686340.Metal_1880	7.612e-158	506.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,1XEQQ@135618|Methylococcales	135618|Methylococcales	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CH3_k127_2295001_0	1116472.MGMO_36c00110	1.057e-161	521.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1XF7M@135618|Methylococcales	135618|Methylococcales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
CH3_k127_2295001_2	1116472.MGMO_136c00020	3.772e-68	235.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1XF7M@135618|Methylococcales	135618|Methylococcales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
CH3_k127_2307227_20	697282.Mettu_0770	7.586e-58	203.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1XDVY@135618|Methylococcales	135618|Methylococcales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
CH3_k127_2307227_15	697282.Mettu_0771	4.272e-87	295.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1XEN4@135618|Methylococcales	135618|Methylococcales	M	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
CH3_k127_2307227_3	243233.MCA1252	8.422e-291	908.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1XEST@135618|Methylococcales	135618|Methylococcales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K01507,ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
CH3_k127_2307227_1	697282.Mettu_2397	0.0	1026.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1XENG@135618|Methylococcales	135618|Methylococcales	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CH3_k127_2307227_17	697282.Mettu_2398	5.975e-78	264.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,1XF0P@135618|Methylococcales	135618|Methylococcales	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
CH3_k127_2307227_6	243233.MCA2272	9.98e-186	584.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1XE7R@135618|Methylococcales	135618|Methylococcales	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
CH3_k127_2307227_0	697282.Mettu_3784	0.0	1259.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1XDRF@135618|Methylococcales	135618|Methylococcales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
CH3_k127_2307227_19	697282.Mettu_3783	1.332e-59	212.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1XF3H@135618|Methylococcales	135618|Methylococcales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
CH3_k127_2307227_9	697282.Mettu_3782	2.849e-141	459.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1XE4B@135618|Methylococcales	135618|Methylococcales	L	PFAM DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
CH3_k127_2307227_12	857087.Metme_4268	3.72e-131	427.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1XE9I@135618|Methylococcales	135618|Methylococcales	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
CH3_k127_2307227_16	686340.Metal_0275	1.241e-79	269.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1XF14@135618|Methylococcales	135618|Methylococcales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CH3_k127_2307227_13	697282.Mettu_3770	1.881e-126	412.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1XEPT@135618|Methylococcales	135618|Methylococcales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CH3_k127_2307227_8	686340.Metal_0277	2.944e-163	524.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1XE0K@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
CH3_k127_2307227_2	697282.Mettu_3767	5.239e-312	970.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1XEIM@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
CH3_k127_2307227_4	697282.Mettu_3766	2.629e-221	692.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1XDQM@135618|Methylococcales	135618|Methylococcales	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
CH3_k127_2307227_24	1129794.C427_4693	1.375e-30	123.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,469JR@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CH3_k127_2307227_23	313606.M23134_00657	1.741e-32	139.0	2AFJ1@1|root,315JT@2|Bacteria,4P311@976|Bacteroidetes,47V6D@768503|Cytophagia	976|Bacteroidetes	S	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	-	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
CH3_k127_2307227_10	1410653.JHVC01000008_gene3146	2.924e-134	438.0	COG3243@1|root,COG3243@2|Bacteria,1V0SA@1239|Firmicutes,24D2G@186801|Clostridia,36RAI@31979|Clostridiaceae	186801|Clostridia	I	PHB de-polymerase C-terminus	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
CH3_k127_2307227_21	1121127.JAFA01000010_gene4042	1.136e-51	186.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2VREB@28216|Betaproteobacteria,1K6Z9@119060|Burkholderiaceae	28216|Betaproteobacteria	I	N-terminal half of MaoC dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
CH3_k127_2307227_18	1116472.MGMO_143c00190	5.509e-74	254.0	COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,1SAB5@1236|Gammaproteobacteria,1XFPV@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
CH3_k127_2307227_5	686340.Metal_3132	3.465e-207	650.0	COG0577@1|root,COG0577@2|Bacteria,1P0WE@1224|Proteobacteria,1S3J4@1236|Gammaproteobacteria,1XE29@135618|Methylococcales	135618|Methylococcales	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CH3_k127_2307227_14	1116472.MGMO_143c00170	2.193e-110	361.0	COG1136@1|root,COG1136@2|Bacteria,1QT8W@1224|Proteobacteria,1RQKT@1236|Gammaproteobacteria,1XDYM@135618|Methylococcales	135618|Methylococcales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_2307227_11	697282.Mettu_3964	3.324e-132	430.0	COG0845@1|root,COG0845@2|Bacteria,1NBFC@1224|Proteobacteria,1S1JT@1236|Gammaproteobacteria,1XE96@135618|Methylococcales	135618|Methylococcales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
CH3_k127_2307227_7	697282.Mettu_3965	2.94e-178	571.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1XEMB@135618|Methylococcales	135618|Methylococcales	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CH3_k127_2307227_22	697282.Mettu_1737	9.973e-40	150.0	2E37U@1|root,32Y7H@2|Bacteria,1N8JQ@1224|Proteobacteria,1SCAH@1236|Gammaproteobacteria,1XFDS@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2956
CH3_k127_2307227_26	189753.AXAS01000021_gene1898	0.0001134	46.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
CH3_k127_2327946_5	477974.Daud_0199	2.359e-34	134.0	COG3587@1|root,COG3587@2|Bacteria	2|Bacteria	L	Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
CH3_k127_2327946_1	335543.Sfum_2855	1.246e-82	277.0	COG1061@1|root,COG3587@1|root,COG1061@2|Bacteria,COG3587@2|Bacteria,1MXFH@1224|Proteobacteria,42YQM@68525|delta/epsilon subdivisions,2WUQJ@28221|Deltaproteobacteria,2MS77@213462|Syntrophobacterales	28221|Deltaproteobacteria	KL	PFAM Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
CH3_k127_2327946_3	686340.Metal_1001	1.906e-69	242.0	COG1309@1|root,COG1309@2|Bacteria,1RG05@1224|Proteobacteria,1S7XG@1236|Gammaproteobacteria,1XEZH@135618|Methylococcales	135618|Methylococcales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CH3_k127_2327946_2	686340.Metal_1000	4.885e-82	277.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1XDZA@135618|Methylococcales	135618|Methylococcales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CH3_k127_2327946_0	396588.Tgr7_1907	6.769e-237	747.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CH3_k127_2327946_4	357808.RoseRS_2431	2.303e-67	235.0	COG1136@1|root,COG1136@2|Bacteria,2G8HT@200795|Chloroflexi,375FM@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_2360814_8	697282.Mettu_2454	3.118e-43	160.0	COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,1XFBI@135618|Methylococcales	135618|Methylococcales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
CH3_k127_2360814_4	697282.Mettu_2536	6.866e-131	427.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1XE35@135618|Methylococcales	135618|Methylococcales	S	Permease YjgP YjgQ	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
CH3_k127_2360814_6	857087.Metme_4390	2.124e-114	379.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1XDW7@135618|Methylococcales	135618|Methylococcales	S	Permease YjgP YjgQ	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
CH3_k127_2360814_2	697282.Mettu_2525	5.2e-200	634.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1XDR9@135618|Methylococcales	135618|Methylococcales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
CH3_k127_2360814_9	697282.Mettu_2524	3.682e-40	153.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1SEQD@1236|Gammaproteobacteria,1XFBN@135618|Methylococcales	135618|Methylococcales	L	PFAM DNA polymerase III chi subunit, HolC	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
CH3_k127_2360814_0	686340.Metal_2510	0.0	1532.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XEJP@135618|Methylococcales	135618|Methylococcales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CH3_k127_2360814_1	697282.Mettu_2522	1.499e-264	824.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XES3@135618|Methylococcales	135618|Methylococcales	NU	type IV, pilus assembly	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CH3_k127_2360814_3	857087.Metme_0460	1.206e-190	601.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1XE3Q@135618|Methylococcales	135618|Methylococcales	U	PFAM Type II secretion system F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CH3_k127_2360814_5	857087.Metme_0461	5.558e-118	386.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1XDZI@135618|Methylococcales	135618|Methylococcales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
CH3_k127_2360814_7	857087.Metme_0462	8.087e-59	210.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1XF4I@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
CH3_k127_2360814_10	697282.Mettu_2518	2.882e-31	124.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1XEEY@135618|Methylococcales	135618|Methylococcales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
CH3_k127_2365427_0	1116472.MGMO_34c00270	4.496e-223	704.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1XEHG@135618|Methylococcales	135618|Methylococcales	F	Belongs to the 5'-nucleotidase family	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C
CH3_k127_2365427_1	857087.Metme_3998	6.038e-215	675.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1XDUY@135618|Methylococcales	135618|Methylococcales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
CH3_k127_2365427_3	696747.NIES39_M00330	9.183e-11	68.0	COG0664@1|root,COG0664@2|Bacteria,1G57E@1117|Cyanobacteria,1HAIX@1150|Oscillatoriales	1117|Cyanobacteria	T	- catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
CH3_k127_2365427_2	243233.MCA2983	1.577e-97	324.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1XF6C@135618|Methylococcales	135618|Methylococcales	P	Inositol monophosphatase family	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
CH3_k127_2415692_0	1470593.BW43_01341	1.497e-175	554.0	COG0451@1|root,COG0451@2|Bacteria,1QUEV@1224|Proteobacteria,1RSBG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Nad-dependent epimerase dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CH3_k127_2415692_1	118005.AWNK01000008_gene502	2.776e-156	503.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
CH3_k127_2415692_3	1249480.B649_08565	1.86e-60	215.0	COG0110@1|root,COG0110@2|Bacteria,1MZ7U@1224|Proteobacteria,42QRM@68525|delta/epsilon subdivisions,2YTCK@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CH3_k127_2415692_2	944546.ABED_0620	7.789e-99	326.0	COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,42ME3@68525|delta/epsilon subdivisions,2YMZ1@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	NeuB family	legI	GO:0003674,GO:0003824,GO:0005975,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016740,GO:0016765,GO:0044238,GO:0071704,GO:1901576	2.5.1.101	ko:K18430	ko00520,map00520	-	R10304	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
CH3_k127_2531821_9	765911.Thivi_1494	1.555e-27	116.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_33
CH3_k127_2531821_11	1123020.AUIE01000021_gene1016	1.749e-07	55.0	COG5583@1|root,COG5583@2|Bacteria,1NGI6@1224|Proteobacteria	1224|Proteobacteria	S	Small protein	HA62_30270	-	-	-	-	-	-	-	-	-	-	-	DUF2292
CH3_k127_2531821_0	1116472.MGMO_144c00130	7.232e-252	784.0	COG3637@1|root,COG3637@2|Bacteria,1QQJF@1224|Proteobacteria,1THXI@1236|Gammaproteobacteria,1XFZ2@135618|Methylococcales	135618|Methylococcales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CH3_k127_2531821_4	686340.Metal_3652	3.264e-155	496.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,1RMAR@1236|Gammaproteobacteria,1XEQ2@135618|Methylococcales	135618|Methylococcales	P	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
CH3_k127_2531821_10	1038869.AXAN01000005_gene5353	8.292e-18	85.0	COG3585@1|root,COG3585@2|Bacteria,1N93I@1224|Proteobacteria,2VW0W@28216|Betaproteobacteria,1K9AV@119060|Burkholderiaceae	28216|Betaproteobacteria	H	domain protein	ssuF	-	-	-	-	-	-	-	-	-	-	-	TOBE
CH3_k127_2531821_8	582744.Msip34_2157	1.055e-77	270.0	COG2200@1|root,COG2200@2|Bacteria,1RM23@1224|Proteobacteria,2VSFS@28216|Betaproteobacteria,2KKU9@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL
CH3_k127_2531821_12	1423816.BACQ01000064_gene2487	8.654e-06	59.0	COG2227@1|root,COG2227@2|Bacteria,1UIIR@1239|Firmicutes,4ISJH@91061|Bacilli,3F5MJ@33958|Lactobacillaceae	91061|Bacilli	H	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CH3_k127_2531821_2	697282.Mettu_2273	1.074e-179	565.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XDN6@135618|Methylococcales	135618|Methylococcales	H	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CH3_k127_2531821_5	1266925.JHVX01000006_gene2100	5.561e-140	453.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VHZF@28216|Betaproteobacteria,371TM@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Bacterial transferase hexapeptide (six repeats)	srpH	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
CH3_k127_2531821_3	697282.Mettu_2275	1.644e-178	561.0	COG0664@1|root,COG2905@1|root,COG0664@2|Bacteria,COG2905@2|Bacteria,1MW6M@1224|Proteobacteria,1RYWM@1236|Gammaproteobacteria,1XDVE@135618|Methylococcales	135618|Methylococcales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_2531821_1	1005048.CFU_2028	5.01e-221	698.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,473XZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aminotransferase class-V	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
CH3_k127_2531821_6	1380387.JADM01000010_gene3937	9.478e-110	364.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1XHD6@135619|Oceanospirillales	135619|Oceanospirillales	K	in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon	cysB	-	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
CH3_k127_2531821_7	697282.Mettu_2207	1.149e-95	317.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,1RN1B@1236|Gammaproteobacteria,1XDZZ@135618|Methylococcales	135618|Methylococcales	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_3
CH3_k127_2640324_1	697282.Mettu_2468	5.495e-102	334.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1XEP3@135618|Methylococcales	135618|Methylococcales	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
CH3_k127_2640324_0	697282.Mettu_2467	1.351e-163	540.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1XDVI@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
CH3_k127_2719825_1	713586.KB900536_gene3039	8.263e-39	149.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales	135613|Chromatiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CH3_k127_2719825_0	396588.Tgr7_2295	4.816e-244	762.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CH3_k127_2720412_3	715451.ambt_03890	2.057e-153	530.0	COG5276@1|root,COG5276@2|Bacteria,1R46A@1224|Proteobacteria,1RY7V@1236|Gammaproteobacteria,46D9Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,LVIVD
CH3_k127_2720412_5	316067.Geob_3308	3.36e-46	193.0	COG2373@1|root,COG3291@1|root,COG5276@1|root,COG2373@2|Bacteria,COG3291@2|Bacteria,COG5276@2|Bacteria,1R7A1@1224|Proteobacteria,42Y4U@68525|delta/epsilon subdivisions,2WU72@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_1,IgGFc_binding
CH3_k127_2720412_2	261292.Nit79A3_3068	8.365e-187	598.0	COG3488@1|root,COG3488@2|Bacteria	2|Bacteria	C	Di-haem oxidoreductase, putative peroxidase	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	DHOR
CH3_k127_2720412_0	243233.MCA1761	0.0	1214.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XDXD@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
CH3_k127_2720412_1	697282.Mettu_2741	0.0	1075.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1XEPA@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
CH3_k127_2720412_4	1116472.MGMO_45c00700	6.001e-102	338.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,1XEI4@135618|Methylococcales	135618|Methylococcales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
CH3_k127_2720412_6	243233.MCA1848	4.072e-42	158.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XE3D@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CH3_k127_2737471_0	857087.Metme_3186	1.466e-215	678.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1XEMT@135618|Methylococcales	135618|Methylococcales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
CH3_k127_2737471_1	686340.Metal_3688	3.146e-125	403.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,1RNC5@1236|Gammaproteobacteria,1XDXG@135618|Methylococcales	135618|Methylococcales	C	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
CH3_k127_2737471_2	349521.HCH_05466	9.809e-28	119.0	2E7BS@1|root,331V2@2|Bacteria,1N7TQ@1224|Proteobacteria,1SD84@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_2737471_3	485916.Dtox_2239	1.971e-19	88.0	28J8Y@1|root,2Z943@2|Bacteria,1UKQN@1239|Firmicutes,25G19@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
CH3_k127_2737471_5	933262.AXAM01000034_gene1578	6.939e-05	52.0	28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,43DCS@68525|delta/epsilon subdivisions,2X8IT@28221|Deltaproteobacteria,2MK0X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4338)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4338
CH3_k127_2737471_4	879212.DespoDRAFT_02081	2.914e-12	74.0	COG4974@1|root,COG4974@2|Bacteria,1NRZQ@1224|Proteobacteria	1224|Proteobacteria	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
CH3_k127_2747345_11	697282.Mettu_4254	1.887e-31	128.0	COG2054@1|root,COG2054@2|Bacteria,1MZY4@1224|Proteobacteria,1S9PH@1236|Gammaproteobacteria,1XFEA@135618|Methylococcales	135618|Methylococcales	S	Amino acid kinase family	-	-	-	-	-	-	-	-	-	-	-	-	AA_kinase
CH3_k127_2747345_6	697282.Mettu_0423	4.226e-70	244.0	28NM7@1|root,33VCA@2|Bacteria,1NVEJ@1224|Proteobacteria,1SNCQ@1236|Gammaproteobacteria,1XEVG@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2959)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2959
CH3_k127_2747345_10	686340.Metal_1893	6.505e-32	131.0	28WBY@1|root,2ZICC@2|Bacteria,1PB9T@1224|Proteobacteria,1SU2T@1236|Gammaproteobacteria,1XFJ6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_2747345_0	697282.Mettu_0425	3.84e-197	630.0	COG0699@1|root,COG0699@2|Bacteria,1RKUD@1224|Proteobacteria,1T537@1236|Gammaproteobacteria,1XE48@135618|Methylococcales	135618|Methylococcales	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
CH3_k127_2747345_3	1283300.ATXB01000001_gene1614	8.876e-114	389.0	COG0699@1|root,COG0699@2|Bacteria,1RGJ8@1224|Proteobacteria,1S42V@1236|Gammaproteobacteria,1XE9A@135618|Methylococcales	135618|Methylococcales	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
CH3_k127_2747345_2	697282.Mettu_0779	1.643e-117	385.0	COG0697@1|root,COG0697@2|Bacteria,1QQY8@1224|Proteobacteria,1RRQ6@1236|Gammaproteobacteria,1XECH@135618|Methylococcales	135618|Methylococcales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CH3_k127_2747345_8	697282.Mettu_0658	7.912e-59	211.0	2AW3I@1|root,31MYD@2|Bacteria,1QJQC@1224|Proteobacteria,1THRG@1236|Gammaproteobacteria,1XFFQ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRA-PH
CH3_k127_2747345_7	1207075.PputUW4_03263	3.204e-66	236.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CH3_k127_2747345_1	686340.Metal_1483	9.623e-163	523.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,1T1MS@1236|Gammaproteobacteria,1XH11@135618|Methylococcales	135618|Methylococcales	P	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
CH3_k127_2747345_12	631362.Thi970DRAFT_04985	5.708e-16	81.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1R97Q@1224|Proteobacteria,1RRDP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
CH3_k127_2747345_4	697282.Mettu_2479	9.535e-73	249.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1XEYT@135618|Methylococcales	135618|Methylococcales	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
CH3_k127_2747345_13	1562701.BBOF01000043_gene1452	7.506e-05	54.0	COG3117@1|root,COG3117@2|Bacteria,1R5UK@1224|Proteobacteria,2VT32@28216|Betaproteobacteria,1KH6Q@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
CH3_k127_2747345_9	697282.Mettu_2481	7.639e-53	192.0	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1XF8P@135618|Methylococcales	135618|Methylococcales	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
CH3_k127_2747345_5	1116472.MGMO_55c00140	1.596e-70	241.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1XEEF@135618|Methylococcales	135618|Methylococcales	S	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
CH3_k127_2754122_4	1123261.AXDW01000002_gene1601	1.792e-32	128.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1X6GG@135614|Xanthomonadales	135614|Xanthomonadales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate	tsaC	GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
CH3_k127_2754122_0	697282.Mettu_2658	0.0	1393.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0454@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1XDMM@135618|Methylococcales	135618|Methylococcales	C	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
CH3_k127_2754122_1	686340.Metal_3274	1.607e-161	514.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria,1XE8V@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
CH3_k127_2754122_2	1552758.NC00_07020	3.063e-127	423.0	COG3746@1|root,COG3746@2|Bacteria,1R45W@1224|Proteobacteria,1RNG5@1236|Gammaproteobacteria,1X52K@135614|Xanthomonadales	135614|Xanthomonadales	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
CH3_k127_2754122_5	686340.Metal_1442	2.116e-09	66.0	COG3317@1|root,COG3317@2|Bacteria,1QIGK@1224|Proteobacteria,1TGB3@1236|Gammaproteobacteria,1XFXR@135618|Methylococcales	135618|Methylococcales	M	Gram-negative-bacterium-type cell outer membrane assembly	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_18
CH3_k127_2754122_3	686340.Metal_2165	2.67e-39	148.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1XEEA@135618|Methylococcales	135618|Methylococcales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
CH3_k127_277411_3	1116472.MGMO_24c00020	8.734e-31	127.0	2AW1V@1|root,31MWH@2|Bacteria,1QJNH@1224|Proteobacteria,1THPA@1236|Gammaproteobacteria,1XF5Y@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_277411_2	697282.Mettu_4334	2.407e-50	184.0	COG0526@1|root,COG0526@2|Bacteria,1RDGI@1224|Proteobacteria,1S8ZA@1236|Gammaproteobacteria,1XFDF@135618|Methylococcales	135618|Methylococcales	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CH3_k127_277411_1	686340.Metal_2805	2.866e-72	246.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria,1XF45@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family (UPF0093)	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
CH3_k127_277411_0	1116472.MGMO_41c00170	5.997e-141	452.0	2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,1RNI9@1236|Gammaproteobacteria,1XEQJ@135618|Methylococcales	135618|Methylococcales	S	PFAM 5'-nucleotidase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5-nucleotidase
CH3_k127_2782950_3	631362.Thi970DRAFT_00292	1.089e-53	193.0	COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,1RY6S@1236|Gammaproteobacteria,1WXWP@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
CH3_k127_2782950_4	765912.Thimo_2622	3.837e-12	69.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1Q7PK@1224|Proteobacteria,1RSF0@1236|Gammaproteobacteria,1WWA3@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_33
CH3_k127_2782950_0	857087.Metme_3511	5.573e-79	265.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1XF2I@135618|Methylococcales	135618|Methylococcales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CH3_k127_2782950_2	686340.Metal_0378	5.269e-59	206.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1XF4R@135618|Methylococcales	135618|Methylococcales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CH3_k127_2782950_1	686340.Metal_0377	1.864e-62	218.0	COG1216@1|root,COG1216@2|Bacteria,1R08C@1224|Proteobacteria,1T52X@1236|Gammaproteobacteria,1XE8T@135618|Methylococcales	135618|Methylococcales	S	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CH3_k127_2795893_8	686340.Metal_3258	1.524e-26	110.0	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,1RRYS@1236|Gammaproteobacteria,1XDSY@135618|Methylococcales	135618|Methylococcales	P	ZIP Zinc transporter	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
CH3_k127_2795893_9	697282.Mettu_1230	2.043e-21	95.0	2E4CR@1|root,32Z86@2|Bacteria,1NJVT@1224|Proteobacteria,1SFKZ@1236|Gammaproteobacteria,1XFQP@135618|Methylococcales	135618|Methylococcales	C	NADH-dependant formate dehydrogenase delta subunit FdsD	-	-	1.17.1.9	ko:K00126	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	FdsD
CH3_k127_2795893_4	697282.Mettu_1229	8.038e-109	361.0	COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,1RNFH@1236|Gammaproteobacteria,1XDUR@135618|Methylococcales	135618|Methylococcales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
CH3_k127_2795893_0	697282.Mettu_1228	0.0	1674.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1XEFY@135618|Methylococcales	135618|Methylococcales	C	Formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CH3_k127_2795893_1	686340.Metal_1452	6.652e-276	854.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XEDW@135618|Methylococcales	135618|Methylococcales	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
CH3_k127_2795893_6	697282.Mettu_1226	3.376e-70	243.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,1T09A@1236|Gammaproteobacteria,1XF7D@135618|Methylococcales	135618|Methylococcales	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	2Fe-2S_thioredx
CH3_k127_2795893_5	857087.Metme_4424	6.928e-91	305.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1XEWQ@135618|Methylococcales	135618|Methylococcales	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
CH3_k127_2795893_2	686340.Metal_3260	1.823e-144	463.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1XEJR@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CH3_k127_2795893_3	697282.Mettu_1561	1.909e-116	382.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1XDUQ@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
CH3_k127_2795893_7	697282.Mettu_3950	6.063e-37	143.0	2FJ56@1|root,34AVD@2|Bacteria,1NZQ6@1224|Proteobacteria,1SS7S@1236|Gammaproteobacteria,1XFAN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_2804053_1	1283300.ATXB01000001_gene1466	7.202e-129	427.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CH3_k127_2804053_0	686340.Metal_3811	3.785e-182	576.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1XDR0@135618|Methylococcales	135618|Methylococcales	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
CH3_k127_2804053_2	1283300.ATXB01000002_gene3007	1.109e-17	86.0	2AUTZ@1|root,31KH1@2|Bacteria,1QIC9@1224|Proteobacteria,1TG6N@1236|Gammaproteobacteria,1XFT8@135618|Methylococcales	135618|Methylococcales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
CH3_k127_2804053_3	697282.Mettu_0299	0.0005123	43.0	COG0720@1|root,COG0720@2|Bacteria,1RKBW@1224|Proteobacteria,1S7FX@1236|Gammaproteobacteria,1XF2V@135618|Methylococcales	135618|Methylococcales	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
CH3_k127_2805640_1	377629.TERTU_1841	2.895e-31	128.0	COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,1RYF5@1236|Gammaproteobacteria,2PPWP@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK
CH3_k127_2805640_2	697282.Mettu_4144	7.485e-27	111.0	COG1183@1|root,COG1183@2|Bacteria,1MYK9@1224|Proteobacteria,1SFHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
CH3_k127_2805640_0	686340.Metal_3270	4.761e-78	269.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1XENE@135618|Methylococcales	135618|Methylococcales	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CH3_k127_2818832_5	857087.Metme_0468	1.625e-24	103.0	COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,1T212@1236|Gammaproteobacteria,1XEUN@135618|Methylococcales	135618|Methylococcales	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	ThiI
CH3_k127_2818832_2	1163408.UU9_04964	1.468e-64	229.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1X4AQ@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
CH3_k127_2818832_4	1198232.CYCME_1019	5.451e-26	115.0	2BW9S@1|root,32Z6F@2|Bacteria,1N7ID@1224|Proteobacteria,1SDWS@1236|Gammaproteobacteria,4616I@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF2818)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2818
CH3_k127_2818832_0	1116472.MGMO_53c00510	2.605e-249	771.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1SX3B@1236|Gammaproteobacteria,1XDZ9@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CH3_k127_2818832_3	686340.Metal_2554	4.377e-61	217.0	COG4244@1|root,COG4244@2|Bacteria,1NB74@1224|Proteobacteria,1SI9C@1236|Gammaproteobacteria,1XF4F@135618|Methylococcales	135618|Methylococcales	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
CH3_k127_2818832_1	857087.Metme_2383	1.395e-161	512.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XE1W@135618|Methylococcales	135618|Methylococcales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CH3_k127_2818832_6	686340.Metal_3127	2.198e-08	61.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,1XDS4@135618|Methylococcales	135618|Methylococcales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_2828693_2	686340.Metal_3979	4.113e-34	132.0	COG2271@1|root,COG2271@2|Bacteria,1MUEK@1224|Proteobacteria,1RMB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major facilitator superfamily	ttuB	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CH3_k127_2828693_3	697282.Mettu_0124	6.426e-30	126.0	2939Q@1|root,2ZQSH@2|Bacteria,1P5RJ@1224|Proteobacteria,1SVBP@1236|Gammaproteobacteria,1XFHZ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_2828693_0	1116472.MGMO_2c00010	1.816e-122	402.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1XECB@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lytic murein transglycosylase B	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
CH3_k127_2828693_1	1116472.MGMO_98c00030	8.361e-37	142.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1XEAP@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
CH3_k127_2853613_2	1286106.MPL1_11648	3.319e-94	314.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,460F5@72273|Thiotrichales	72273|Thiotrichales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CH3_k127_2853613_3	857087.Metme_3964	1.544e-52	188.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1XFFD@135618|Methylococcales	135618|Methylococcales	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
CH3_k127_2853613_4	472759.Nhal_0929	1.547e-36	144.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1WYKN@135613|Chromatiales	135613|Chromatiales	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
CH3_k127_2853613_0	1116472.MGMO_37c00170	7.981e-132	426.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XDWR@135618|Methylococcales	135618|Methylococcales	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CH3_k127_2853613_1	1116472.MGMO_37c00180	2.233e-125	405.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1SJRD@1236|Gammaproteobacteria,1XEFB@135618|Methylococcales	135618|Methylococcales	M	Acyl- acyl-carrier-protein --UDP-N-acetylglucosamine O-acyltransferase	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
CH3_k127_2853613_5	406552.NJ7G_1801	6.948e-08	54.0	COG0589@1|root,arCOG02053@2157|Archaea,2XY7I@28890|Euryarchaeota,23WFY@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CH3_k127_2920558_9	697282.Mettu_2692	3.064e-10	61.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1XE0N@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CH3_k127_2920558_8	857087.Metme_3938	1.203e-43	163.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,1XFBY@135618|Methylococcales	135618|Methylococcales	U	Preprotein translocase subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
CH3_k127_2920558_0	697282.Mettu_2694	1.319e-255	801.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1XDXB@135618|Methylococcales	135618|Methylococcales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
CH3_k127_2920558_4	1116472.MGMO_86c00050	4.208e-121	398.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1XDU7@135618|Methylococcales	135618|Methylococcales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CH3_k127_2920558_5	187272.Mlg_1248	8.023e-71	241.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1WYAE@135613|Chromatiales	135613|Chromatiales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
CH3_k127_2920558_2	697282.Mettu_2697	5.421e-175	557.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1XE4Q@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
CH3_k127_2920558_7	697282.Mettu_2698	3.741e-54	199.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1XEY1@135618|Methylococcales	135618|Methylococcales	NU	Pilus biogenesis	-	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_19,TPR_2,TPR_8
CH3_k127_2920558_1	697282.Mettu_2699	2.878e-202	636.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XDXR@135618|Methylococcales	135618|Methylococcales	J	PFAM Aminoacyl-tRNA synthetase, class II (G H P S), conserved region	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
CH3_k127_2920558_6	1116472.MGMO_86c00100	1.371e-69	241.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1XF0Z@135618|Methylococcales	135618|Methylococcales	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
CH3_k127_2920558_3	697282.Mettu_2701	1.066e-133	437.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1XE8E@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
CH3_k127_297088_1	857087.Metme_1830	1.037e-63	223.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1XGNR@135618|Methylococcales	135618|Methylococcales	P	PFAM Cation H exchanger	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
CH3_k127_297088_0	697282.Mettu_2381	1.011e-198	629.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1XES9@135618|Methylococcales	135618|Methylococcales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
CH3_k127_297088_2	697282.Mettu_0324	7.886e-10	59.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1XE8G@135618|Methylococcales	135618|Methylococcales	C	alcohol dehydrogenase	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
CH3_k127_307556_4	686340.Metal_2392	1.928e-284	885.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1XEC9@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
CH3_k127_307556_5	243159.AFE_1741	2.805e-276	863.0	COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,1RQMR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KQ	transcriptional regulator	acoR	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
CH3_k127_307556_1	243159.AFE_1742	2.285e-306	943.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria	1224|Proteobacteria	C	belongs to the aldehyde dehydrogenase family	aldB	-	1.2.1.3	ko:K00128,ko:K00138	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CH3_k127_307556_13	243159.AFE_1743	2.95e-64	224.0	COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,1S7GJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF779)	-	-	-	ko:K09959	-	-	-	-	ko00000	-	-	-	DUF779
CH3_k127_307556_2	697282.Mettu_2158	2.13e-303	939.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1XDMF@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
CH3_k127_307556_7	857087.Metme_4503	2.988e-191	608.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1XEPU@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
CH3_k127_307556_15	857087.Metme_4504	1.109e-61	214.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1XF6N@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
CH3_k127_307556_6	697282.Mettu_2155	8.169e-270	835.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1XEAV@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
CH3_k127_307556_8	1116472.MGMO_115c00100	1.167e-145	465.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1XEK1@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
CH3_k127_307556_3	686340.Metal_3771	3.702e-301	927.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1XEKJ@135618|Methylococcales	135618|Methylococcales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	-	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
CH3_k127_307556_16	697282.Mettu_2152	1.963e-56	201.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1XF4Q@135618|Methylococcales	135618|Methylococcales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
CH3_k127_307556_14	697282.Mettu_2151	2.229e-62	218.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,1XF7Q@135618|Methylococcales	135618|Methylococcales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
CH3_k127_307556_17	1116472.MGMO_115c00060	2.062e-45	165.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1XFHC@135618|Methylococcales	135618|Methylococcales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
CH3_k127_307556_10	1116472.MGMO_115c00050	2.57e-138	443.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1XE4P@135618|Methylococcales	135618|Methylococcales	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
CH3_k127_307556_20	697282.Mettu_2148	4.829e-32	128.0	COG3312@1|root,COG3312@2|Bacteria,1NDM1@1224|Proteobacteria,1THRJ@1236|Gammaproteobacteria,1XFG2@135618|Methylococcales	135618|Methylococcales	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
CH3_k127_307556_11	243233.MCA2501	2.994e-82	280.0	2C8FP@1|root,340K8@2|Bacteria,1NXGW@1224|Proteobacteria,1THKW@1236|Gammaproteobacteria,1XESB@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_307556_9	857087.Metme_0394	2.183e-141	451.0	28NX2@1|root,2ZBUV@2|Bacteria,1RD3N@1224|Proteobacteria,1SP2D@1236|Gammaproteobacteria,1XETI@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_307556_12	857087.Metme_3353	5.524e-81	273.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,1S24N@1236|Gammaproteobacteria,1XF7B@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
CH3_k127_307556_19	686340.Metal_0625	3.181e-38	144.0	COG3905@1|root,COG3905@2|Bacteria,1PPSD@1224|Proteobacteria,1TCGN@1236|Gammaproteobacteria,1XGTS@135618|Methylococcales	135618|Methylococcales	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_307556_18	686340.Metal_0626	1.084e-41	154.0	COG3668@1|root,COG3668@2|Bacteria,1PZJZ@1224|Proteobacteria,1TB9H@1236|Gammaproteobacteria,1XFXW@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Addiction module toxin, RelE StbE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
CH3_k127_307556_0	243233.MCA0936	0.0	1101.0	COG1203@1|root,COG1203@2|Bacteria,1MX99@1224|Proteobacteria,1RMM0@1236|Gammaproteobacteria,1XFCE@135618|Methylococcales	135618|Methylococcales	L	helicase Cas3	-	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD
CH3_k127_3080400_1	686340.Metal_1880	1.048e-84	283.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,1XEQQ@135618|Methylococcales	135618|Methylococcales	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
CH3_k127_3080400_5	290317.Cpha266_2600	4.271e-16	81.0	COG0503@1|root,COG0503@2|Bacteria	2|Bacteria	F	purine ribonucleoside salvage	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
CH3_k127_3080400_2	1444770.AF72_13705	5.303e-37	142.0	COG4226@1|root,COG4226@2|Bacteria,1MZYR@1224|Proteobacteria,1SAHX@1236|Gammaproteobacteria,1X8RG@135614|Xanthomonadales	135614|Xanthomonadales	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
CH3_k127_3080400_3	269799.Gmet_2592	6.027e-33	128.0	2CT64@1|root,32SSN@2|Bacteria,1N7H4@1224|Proteobacteria,42VGX@68525|delta/epsilon subdivisions,2WRDX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CH3_k127_3080400_6	1562701.BBOF01000061_gene1660	1.232e-13	73.0	COG2963@1|root,COG2963@2|Bacteria,1NDI2@1224|Proteobacteria,2WEUS@28216|Betaproteobacteria,1KADN@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
CH3_k127_3080400_7	697282.Mettu_2672	1.473e-09	61.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1XEP6@135618|Methylococcales	135618|Methylococcales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
CH3_k127_3080400_4	1300345.LF41_48	2.539e-32	136.0	COG0028@1|root,COG1520@1|root,COG3391@1|root,COG3693@1|root,COG0028@2|Bacteria,COG1520@2|Bacteria,COG3391@2|Bacteria,COG3693@2|Bacteria,1QYUP@1224|Proteobacteria	1224|Proteobacteria	EH	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR
CH3_k127_3080400_0	686340.Metal_1879	5.488e-137	459.0	28IA9@1|root,2Z9M7@2|Bacteria,1QTVI@1224|Proteobacteria,1T1IN@1236|Gammaproteobacteria,1XEN0@135618|Methylococcales	135618|Methylococcales	S	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
CH3_k127_3110670_0	243233.MCA2039	1.59e-309	954.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1XEDS@135618|Methylococcales	135618|Methylococcales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
CH3_k127_3176735_0	697282.Mettu_3395	5.258e-168	539.0	COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,1RS1G@1236|Gammaproteobacteria,1XEMQ@135618|Methylococcales	135618|Methylococcales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CH3_k127_3176735_1	697282.Mettu_3677	1.63e-162	513.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1XEAR@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
CH3_k127_3218621_0	1116472.MGMO_55c00350	1.767e-212	672.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XENK@135618|Methylococcales	135618|Methylococcales	M	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
CH3_k127_3218621_2	506534.Rhein_0729	6.068e-32	129.0	COG0642@1|root,COG4251@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WVYT@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
CH3_k127_3218621_1	697282.Mettu_3233	2.295e-169	534.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1XE8I@135618|Methylococcales	135618|Methylococcales	H	TIGRFAM Coenzyme PQQ biosynthesis protein E	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CH3_k127_3224526_7	1116472.MGMO_8c00320	3.215e-94	313.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1XE7A@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CH3_k127_3224526_4	1116472.MGMO_94c00480	6.377e-109	358.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1XEKV@135618|Methylococcales	135618|Methylococcales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
CH3_k127_3224526_11	686340.Metal_1325	1.006e-26	112.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria,1XFRA@135618|Methylococcales	135618|Methylococcales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CH3_k127_3224526_12	697282.Mettu_1669	2.877e-12	68.0	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1XFSS@135618|Methylococcales	135618|Methylococcales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
CH3_k127_3224526_10	697282.Mettu_1668	6.53e-46	167.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1XF9W@135618|Methylococcales	135618|Methylococcales	E	PFAM Phosphoribosyl-ATP pyrophosphohydrolase	hisE	GO:0000105,GO:0003674,GO:0003824,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
CH3_k127_3224526_8	686340.Metal_1328	8.037e-63	221.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1XF4K@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
CH3_k127_3224526_2	686340.Metal_1329	1.19e-143	458.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1XE1I@135618|Methylococcales	135618|Methylococcales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CH3_k127_3224526_3	686340.Metal_1330	4.087e-129	415.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1XETV@135618|Methylococcales	135618|Methylococcales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CH3_k127_3224526_6	697282.Mettu_1664	7.259e-95	316.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1XDZU@135618|Methylococcales	135618|Methylococcales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	GO:0000105,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CH3_k127_3224526_5	686340.Metal_1332	6.243e-101	331.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1XDKI@135618|Methylococcales	135618|Methylococcales	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
CH3_k127_3224526_9	1266925.JHVX01000001_gene2441	3.387e-54	194.0	COG0517@1|root,COG0517@2|Bacteria,1QTXQ@1224|Proteobacteria,2VWDB@28216|Betaproteobacteria,3734T@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CH3_k127_3224526_0	261292.Nit79A3_3272	0.0	1802.0	COG2202@1|root,COG3447@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3447@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,373T6@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,EAL,GGDEF,HAMP,MASE1,PAS,PAS_3,PAS_4,PAS_8,PAS_9
CH3_k127_3224526_1	857087.Metme_0445	1.236e-173	554.0	COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1XDIY@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CH3_k127_3233600_1	697282.Mettu_1375	7.915e-37	141.0	COG1461@1|root,COG1461@2|Bacteria,1MXIB@1224|Proteobacteria,1RPJ7@1236|Gammaproteobacteria,1XF0H@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Dihydroxyacetone kinase	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
CH3_k127_3233600_2	697282.Mettu_1661	3.291e-25	106.0	COG3313@1|root,COG3313@2|Bacteria,1QIZR@1224|Proteobacteria,1TGWK@1236|Gammaproteobacteria,1XGUB@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1289)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1289
CH3_k127_3233600_0	686340.Metal_3469	1.104e-121	401.0	COG0524@1|root,COG0524@2|Bacteria,1MWX4@1224|Proteobacteria,1RU49@1236|Gammaproteobacteria,1XETS@135618|Methylococcales	135618|Methylococcales	G	Belongs to the carbohydrate kinase PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CH3_k127_3244677_4	697282.Mettu_2994	6.139e-66	226.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1XE5Z@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
CH3_k127_3244677_3	686340.Metal_1183	3.328e-78	265.0	COG4636@1|root,COG4636@2|Bacteria,1RJC2@1224|Proteobacteria,1S7B0@1236|Gammaproteobacteria,1XF6F@135618|Methylococcales	135618|Methylococcales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CH3_k127_3244677_0	697282.Mettu_2996	9.006e-171	546.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1XE90@135618|Methylococcales	135618|Methylococcales	O	TIGRFAM SUF system FeS cluster assembly, SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
CH3_k127_3244677_1	686340.Metal_1181	3.521e-134	430.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1XE5C@135618|Methylococcales	135618|Methylococcales	O	ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
CH3_k127_3244677_2	1116472.MGMO_8c00670	6.909e-81	269.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1XEJ8@135618|Methylococcales	135618|Methylococcales	O	FeS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
CH3_k127_3251010_1	697282.Mettu_3842	6.872e-256	828.0	COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,1RQFM@1236|Gammaproteobacteria,1XERR@135618|Methylococcales	135618|Methylococcales	L	P-loop containing region of AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
CH3_k127_3251010_18	1207075.PputUW4_02254	4.131e-26	124.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,1RQIV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Protein of unknown function (DUF3300)	yacH	-	-	-	-	-	-	-	-	-	-	-	DUF3300
CH3_k127_3251010_8	338966.Ppro_0418	7.092e-78	272.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,43T3T@69541|Desulfuromonadales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
CH3_k127_3251010_19	686340.Metal_2664	4.1e-23	105.0	2EAWF@1|root,31QMM@2|Bacteria,1QJRB@1224|Proteobacteria,1THSJ@1236|Gammaproteobacteria,1XFS8@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3251010_0	857087.Metme_0490	0.0	1124.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,1XDKJ@135618|Methylococcales	135618|Methylococcales	K	S1, RNA binding domain	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
CH3_k127_3251010_2	697282.Mettu_2337	2.07e-238	753.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1XDJ9@135618|Methylococcales	135618|Methylococcales	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
CH3_k127_3251010_17	1116472.MGMO_11c00640	5.02e-32	130.0	2B2IA@1|root,31V3C@2|Bacteria,1QJQD@1224|Proteobacteria,1THRH@1236|Gammaproteobacteria,1XFFW@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3251010_16	686340.Metal_3936	2.28e-33	134.0	COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,1S8TU@1236|Gammaproteobacteria,1XFM1@135618|Methylococcales	135618|Methylococcales	S	Cupin domain	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
CH3_k127_3251010_6	697282.Mettu_2538	9.069e-120	390.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1XDS5@135618|Methylococcales	135618|Methylococcales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
CH3_k127_3251010_3	697282.Mettu_2540	8.946e-162	515.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1XE5V@135618|Methylococcales	135618|Methylococcales	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
CH3_k127_3251010_7	686340.Metal_1799	3.071e-78	269.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1XDPV@135618|Methylococcales	135618|Methylococcales	Q	MlaC protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
CH3_k127_3251010_12	857087.Metme_0098	2.349e-53	192.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1XF63@135618|Methylococcales	135618|Methylococcales	P	ApaG domain	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
CH3_k127_3251010_5	697282.Mettu_1998	2.13e-121	396.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1XESJ@135618|Methylococcales	135618|Methylococcales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
CH3_k127_3251010_20	765911.Thivi_2813	1.296e-22	98.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3251010_14	261292.Nit79A3_3409	1.345e-43	160.0	2EB38@1|root,33540@2|Bacteria,1NBMZ@1224|Proteobacteria,2W4PA@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3251010_22	425104.Ssed_3626	4.404e-06	50.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	DUF5128
CH3_k127_3251010_11	686340.Metal_2076	3.409e-57	202.0	COG0639@1|root,COG0639@2|Bacteria,1N2CE@1224|Proteobacteria,1SWJI@1236|Gammaproteobacteria,1XGII@135618|Methylococcales	135618|Methylococcales	T	Domain of unknown function DUF29	-	-	-	-	-	-	-	-	-	-	-	-	DUF29
CH3_k127_3251010_9	697282.Mettu_0019	8.332e-65	226.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,1S5ZI@1236|Gammaproteobacteria,1XF43@135618|Methylococcales	135618|Methylococcales	P	Belongs to the Fur family	-	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
CH3_k127_3251010_13	1116472.MGMO_223c00010	3.026e-50	185.0	29HEN@1|root,304C1@2|Bacteria,1QJNM@1224|Proteobacteria,1THPG@1236|Gammaproteobacteria,1XF6S@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
CH3_k127_3251010_10	395493.BegalDRAFT_1387	1.355e-58	209.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,1S3YY@1236|Gammaproteobacteria,4611P@72273|Thiotrichales	72273|Thiotrichales	T	PFAM response regulator receiver	-	-	-	ko:K07183	-	-	-	-	ko00000,ko02022	-	-	-	ANTAR,Response_reg
CH3_k127_3251010_4	768671.ThimaDRAFT_4416	4.497e-144	467.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,1X036@135613|Chromatiales	135613|Chromatiales	P	NMT1-like family	-	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
CH3_k127_3251010_15	269797.Mbar_A0582	6.382e-34	141.0	COG3271@1|root,arCOG06761@2157|Archaea,2Y40P@28890|Euryarchaeota	28890|Euryarchaeota	S	Peptidase C39 family	-	-	-	ko:K06992	-	-	-	-	ko00000	-	-	-	Peptidase_C39_2
CH3_k127_3305166_0	697282.Mettu_4255	2.624e-198	628.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XDNC@135618|Methylococcales	135618|Methylococcales	EH	synthase component I	pabB	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
CH3_k127_3305166_1	686340.Metal_3518	1.169e-66	234.0	COG1548@1|root,COG1548@2|Bacteria,1RAMA@1224|Proteobacteria,1S26G@1236|Gammaproteobacteria,1XDXI@135618|Methylococcales	135618|Methylococcales	GK	PFAM Hydantoinase oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydantoinase_A
CH3_k127_3319681_5	1283300.ATXB01000001_gene1942	3.526e-07	53.0	COG4968@1|root,COG4968@2|Bacteria,1NAXM@1224|Proteobacteria,1SGAU@1236|Gammaproteobacteria,1XF95@135618|Methylococcales	135618|Methylococcales	U	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CH3_k127_3319681_3	1116472.MGMO_61c00330	1.346e-25	111.0	COG2165@1|root,COG2165@2|Bacteria,1R1HH@1224|Proteobacteria,1T53E@1236|Gammaproteobacteria,1XFHB@135618|Methylococcales	135618|Methylococcales	U	overlaps another CDS with the same product name	-	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CH3_k127_3319681_4	713586.KB900536_gene2471	1.355e-22	104.0	COG4970@1|root,COG4970@2|Bacteria,1NBWI@1224|Proteobacteria,1S5MN@1236|Gammaproteobacteria,1WY85@135613|Chromatiales	135613|Chromatiales	U	General secretion pathway protein H	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
CH3_k127_3319681_1	697282.Mettu_1872	7.966e-56	199.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S69B@1236|Gammaproteobacteria,1XF93@135618|Methylococcales	135618|Methylococcales	U	TIGRFAM general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CH3_k127_3319681_0	697282.Mettu_1871	9.422e-130	426.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1XEBQ@135618|Methylococcales	135618|Methylococcales	U	type II secretion system	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
CH3_k127_3319681_2	1116472.MGMO_61c00370	2.308e-49	179.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XE8Y@135618|Methylococcales	135618|Methylococcales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
CH3_k127_3334667_6	1177179.A11A3_04500	5.28e-55	197.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1XJND@135619|Oceanospirillales	135619|Oceanospirillales	D	Maf-like protein	maf-2	-	-	-	-	-	-	-	-	-	-	-	Maf
CH3_k127_3334667_4	857087.Metme_1081	5.311e-65	229.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,1XF3W@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SLT
CH3_k127_3334667_1	857087.Metme_1080	2.781e-179	569.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,1RNTW@1236|Gammaproteobacteria,1XEEB@135618|Methylococcales	135618|Methylococcales	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
CH3_k127_3334667_0	697282.Mettu_3955	3.791e-225	709.0	COG0249@1|root,COG0249@2|Bacteria,1R85X@1224|Proteobacteria,1RYSC@1236|Gammaproteobacteria,1XE12@135618|Methylococcales	135618|Methylococcales	L	PFAM DNA mismatch repair protein MutS, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
CH3_k127_3334667_2	298386.PBPRB0863	4.958e-81	279.0	COG2010@1|root,COG2010@2|Bacteria,1RCYF@1224|Proteobacteria,1SEBP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
CH3_k127_3334667_7	290317.Cpha266_0018	5.269e-41	157.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
CH3_k127_3334667_8	886293.Sinac_0357	7.691e-24	103.0	COG1609@1|root,COG1609@2|Bacteria,2J56N@203682|Planctomycetes	2|Bacteria	K	PFAM Rhodopirellula transposase	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
CH3_k127_3334667_3	1297569.MESS2_1220011	2.246e-66	229.0	COG1609@1|root,COG1609@2|Bacteria,1R5GE@1224|Proteobacteria,2UC92@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
CH3_k127_3334667_5	857087.Metme_4604	1.642e-64	225.0	COG4229@1|root,COG4229@2|Bacteria,1R3V9@1224|Proteobacteria,1RP5Y@1236|Gammaproteobacteria,1XE85@135618|Methylococcales	135618|Methylococcales	C	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)	mtnC	-	3.1.3.77	ko:K09880	ko00270,ko01100,map00270,map01100	M00034	R07395	RC02779	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CH3_k127_3386696_3	1116472.MGMO_63c00090	2.712e-90	304.0	COG1809@1|root,COG1809@2|Bacteria,1PPRI@1224|Proteobacteria,1THYG@1236|Gammaproteobacteria,1XG1N@135618|Methylococcales	135618|Methylococcales	H	(2R)-phospho-3-sulfolactate synthase (ComA)	-	-	-	-	-	-	-	-	-	-	-	-	ComA
CH3_k127_3386696_1	1116472.MGMO_63c00080	3.959e-128	417.0	COG1809@1|root,COG1809@2|Bacteria,1PPRJ@1224|Proteobacteria,1SKEQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphosulfolactate synthase activity	-	-	4.4.1.19	ko:K08097	ko00680,ko01120,map00680,map01120	M00358	R07476	RC01799	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CH3_k127_3386696_2	1116472.MGMO_63c00070	7.227e-125	405.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,1SF6X@1236|Gammaproteobacteria,1XG45@135618|Methylococcales	135618|Methylococcales	I	Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3386696_0	1116472.MGMO_63c00060	5.749e-142	456.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,1RQB6@1236|Gammaproteobacteria,1XG83@135618|Methylococcales	135618|Methylococcales	I	Coenzyme A transferase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
CH3_k127_3386696_4	1116472.MGMO_63c00050	5.442e-76	262.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMMZ@1236|Gammaproteobacteria,1XG2S@135618|Methylococcales	135618|Methylococcales	IQ	PFAM short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CH3_k127_3386696_5	663610.JQKO01000004_gene2747	4.887e-17	81.0	COG1249@1|root,COG1249@2|Bacteria,1R75Y@1224|Proteobacteria,2UPSV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.5	ko:K22364	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
CH3_k127_3545316_4	1105367.CG50_15490	2.151e-18	86.0	COG2801@1|root,COG2801@2|Bacteria,1MVQ9@1224|Proteobacteria,2TTHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	rve,rve_3
CH3_k127_3545316_2	1528098.NOVO_04990	1.221e-43	166.0	COG2801@1|root,COG2801@2|Bacteria,1MVQ9@1224|Proteobacteria,2TTHG@28211|Alphaproteobacteria,47F4D@766|Rickettsiales	766|Rickettsiales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CH3_k127_3545316_0	857087.Metme_3788	4.426e-281	869.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,1RR7N@1236|Gammaproteobacteria,1XGKM@135618|Methylococcales	1236|Gammaproteobacteria	L	PFAM Integrase, catalytic core	-	-	-	-	-	-	-	-	-	-	-	-	rve
CH3_k127_3545316_1	279714.FuraDRAFT_1080	8.638e-113	369.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2W9R8@28216|Betaproteobacteria,2KT5U@206351|Neisseriales	206351|Neisseriales	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CH3_k127_3555052_3	765914.ThisiDRAFT_0621	5.312e-06	50.0	COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria	1224|Proteobacteria	M	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
CH3_k127_3555052_0	1163617.SCD_n02172	3.27e-172	553.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CZB,DUF4118,EAL,GGDEF,LapD_MoxY_N,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd
CH3_k127_3555052_1	686340.Metal_1312	1.268e-23	103.0	COG0656@1|root,COG0656@2|Bacteria,1MWFS@1224|Proteobacteria,1RMX6@1236|Gammaproteobacteria,1XE6X@135618|Methylococcales	135618|Methylococcales	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CH3_k127_3566762_0	686340.Metal_0900	3.403e-65	230.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,1XF1M@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
CH3_k127_3566762_1	686340.Metal_0899	4.258e-27	113.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1XDR3@135618|Methylococcales	135618|Methylococcales	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
CH3_k127_3596540_1	6087.XP_002163048.2	1.243e-136	440.0	COG0538@1|root,KOG1526@2759|Eukaryota,38CG3@33154|Opisthokonta,3BATQ@33208|Metazoa	33208|Metazoa	C	isocitrate dehydrogenase (NADP+) activity	IDH2	GO:0000287,GO:0002791,GO:0002792,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005777,GO:0005829,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006102,GO:0006103,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007399,GO:0008150,GO:0008152,GO:0008285,GO:0009058,GO:0009060,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0010721,GO:0014013,GO:0014014,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019752,GO:0019866,GO:0022008,GO:0030154,GO:0030334,GO:0030336,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0034641,GO:0034654,GO:0040012,GO:0040013,GO:0042127,GO:0042579,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0045595,GO:0045596,GO:0046483,GO:0046496,GO:0046872,GO:0048519,GO:0048523,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050708,GO:0050709,GO:0050767,GO:0050768,GO:0050789,GO:0050793,GO:0050794,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051093,GO:0051186,GO:0051188,GO:0051223,GO:0051224,GO:0051239,GO:0051241,GO:0051270,GO:0051271,GO:0051960,GO:0051961,GO:0055086,GO:0055114,GO:0060251,GO:0060253,GO:0060284,GO:0065007,GO:0070013,GO:0070201,GO:0071704,GO:0072350,GO:0072524,GO:0072525,GO:0090087,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903531,GO:1903975,GO:1903976,GO:1904464,GO:1904465,GO:1904950,GO:2000026,GO:2000145,GO:2000146	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CH3_k127_3596540_0	697282.Mettu_4276	5.653e-143	464.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1XETT@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
CH3_k127_3596540_2	697282.Mettu_4275	5.274e-34	132.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XDVV@135618|Methylococcales	135618|Methylococcales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_3604038_6	1288494.EBAPG3_29530	4.364e-126	413.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,371YG@32003|Nitrosomonadales	28216|Betaproteobacteria	M	TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	cpsB	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
CH3_k127_3604038_3	697282.Mettu_4200	3.857e-172	552.0	COG1109@1|root,COG1109@2|Bacteria,1MUB3@1224|Proteobacteria,1RNFZ@1236|Gammaproteobacteria,1XEA7@135618|Methylococcales	135618|Methylococcales	G	PFAM Alpha-D-phosphohexomutase, alpha beta alpha domain I	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CH3_k127_3604038_5	864051.BurJ1DRAFT_1271	4.201e-147	470.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2VK2N@28216|Betaproteobacteria,1KIT7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
CH3_k127_3604038_1	1000565.METUNv1_01353	2.383e-213	665.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2VIBX@28216|Betaproteobacteria,2KVB6@206389|Rhodocyclales	206389|Rhodocyclales	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
CH3_k127_3604038_7	686340.Metal_3701	1.65e-118	391.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1XEEG@135618|Methylococcales	135618|Methylococcales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CH3_k127_3604038_10	686340.Metal_3702	1.448e-70	244.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1XDQ9@135618|Methylococcales	135618|Methylococcales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
CH3_k127_3604038_9	857087.Metme_0534	9.992e-77	259.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1XF23@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
CH3_k127_3604038_4	1283300.ATXB01000001_gene225	2.554e-168	535.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,1XDMP@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CH3_k127_3604038_11	697282.Mettu_0642	2.808e-67	231.0	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,1S970@1236|Gammaproteobacteria,1XF6X@135618|Methylococcales	135618|Methylococcales	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CH3_k127_3604038_8	1026882.MAMP_02394	2.253e-97	321.0	COG1795@1|root,COG1795@2|Bacteria,1MWYS@1224|Proteobacteria,1S3E5@1236|Gammaproteobacteria,461JV@72273|Thiotrichales	72273|Thiotrichales	S	PFAM Formaldehyde-activating enzyme (Fae)	-	-	-	-	-	-	-	-	-	-	-	-	Fae
CH3_k127_3604038_12	697282.Mettu_2395	2.277e-58	207.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,1XFC1@135618|Methylococcales	135618|Methylococcales	H	MoaE protein	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
CH3_k127_3604038_14	686340.Metal_0905	1.296e-22	98.0	COG1977@1|root,COG1977@2|Bacteria,1NHG7@1224|Proteobacteria,1TG6J@1236|Gammaproteobacteria,1XFT3@135618|Methylococcales	135618|Methylococcales	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
CH3_k127_3604038_13	857087.Metme_3719	5.248e-32	133.0	2AUHS@1|root,31K65@2|Bacteria,1QI00@1224|Proteobacteria,1TFSE@1236|Gammaproteobacteria,1XFCB@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3604038_0	1116472.MGMO_122c00030	5.571e-234	734.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1XEJG@135618|Methylococcales	135618|Methylococcales	F	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
CH3_k127_3604038_15	317936.Nos7107_1803	9.422e-15	78.0	2CFW7@1|root,32S2M@2|Bacteria,1G83P@1117|Cyanobacteria,1HPE5@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3604038_2	686340.Metal_2986	1.496e-199	626.0	COG1541@1|root,COG1541@2|Bacteria,1R8T9@1224|Proteobacteria,1S1JC@1236|Gammaproteobacteria,1XEUW@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
CH3_k127_3631232_1	697282.Mettu_3723	6.239e-219	687.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1XE7J@135618|Methylococcales	135618|Methylococcales	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CH3_k127_3631232_2	697282.Mettu_3722	1.608e-189	603.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1XERI@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CH3_k127_3631232_5	686340.Metal_3840	5.705e-138	446.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1XDRH@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM lipopolysaccharide heptosyltransferase I	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CH3_k127_3631232_4	697282.Mettu_1907	8.282e-148	474.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1XEXK@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lipopolysaccharide heptosyltransferase II	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CH3_k127_3631232_3	1116472.MGMO_61c00400	1.982e-177	559.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1XEIE@135618|Methylococcales	135618|Methylococcales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CH3_k127_3631232_0	697282.Mettu_1909	0.0	1149.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XE97@135618|Methylococcales	135618|Methylococcales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
CH3_k127_3631232_6	697282.Mettu_1926	3.156e-28	121.0	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1XEJY@135618|Methylococcales	135618|Methylococcales	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
CH3_k127_3632227_1	1116472.MGMO_115c00260	4.669e-192	602.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XE89@135618|Methylococcales	135618|Methylococcales	F	RNA helicase	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
CH3_k127_3632227_3	686340.Metal_0850	2.686e-20	94.0	2AVDR@1|root,31M5E@2|Bacteria,1QJ0C@1224|Proteobacteria,1SU5E@1236|Gammaproteobacteria,1XGW8@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3632227_2	697282.Mettu_2738	3.543e-89	297.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,1S5AA@1236|Gammaproteobacteria,1XFBJ@135618|Methylococcales	135618|Methylococcales	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
CH3_k127_3632227_0	243233.MCA1006	1.778e-249	793.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1XG8Z@135618|Methylococcales	135618|Methylococcales	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,Acyltransferase,PP-binding
CH3_k127_3632227_4	1111454.HMPREF1250_1977	3.25e-08	59.0	COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,4H55G@909932|Negativicutes	909932|Negativicutes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CH3_k127_3667923_2	85643.Tmz1t_3787	2.589e-28	117.0	COG3385@1|root,COG3385@2|Bacteria,1QT8J@1224|Proteobacteria,2VP4B@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
CH3_k127_3667923_3	266265.Bxe_C0837	1.398e-11	65.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2VP2D@28216|Betaproteobacteria,1K531@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF4096
CH3_k127_3667923_0	743299.Acife_2300	1.32e-229	717.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
CH3_k127_3667923_1	697282.Mettu_3104	1.53e-33	131.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1XE2N@135618|Methylococcales	135618|Methylococcales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
CH3_k127_3668207_2	697282.Mettu_4307	2.721e-59	211.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,1XESY@135618|Methylococcales	135618|Methylococcales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
CH3_k127_3668207_0	1116472.MGMO_6c00180	1.1e-159	509.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1XEUY@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
CH3_k127_3668207_1	1116472.MGMO_93c00020	3.571e-85	284.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1XG1C@135618|Methylococcales	135618|Methylococcales	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
CH3_k127_3668703_4	472759.Nhal_1553	6.262e-62	223.0	COG3659@1|root,COG3659@2|Bacteria,1QIBX@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Carbohydrate-selective porin OprB	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
CH3_k127_3668703_1	522306.CAP2UW1_0198	2.384e-144	463.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2VN83@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CH3_k127_3668703_0	663610.JQKO01000001_gene622	1.82e-286	886.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,3NAFW@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Sulfatase	aslA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase,Sulfatase_C
CH3_k127_3668703_8	566466.NOR53_1467	2.405e-07	54.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1J56J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Small-conductance mechanosensitive channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
CH3_k127_3668703_6	153948.NAL212_1795	8.252e-30	120.0	2DUS0@1|root,33RYR@2|Bacteria,1NS4C@1224|Proteobacteria,2WDS9@28216|Betaproteobacteria,3747E@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3668703_7	1301098.PKB_1750	1.41e-20	96.0	2C0Z5@1|root,30A8M@2|Bacteria,1QT69@1224|Proteobacteria,1STUY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3668703_3	314278.NB231_02263	1.102e-66	235.0	2A5PE@1|root,30UE9@2|Bacteria,1PX3T@1224|Proteobacteria,1TA9Y@1236|Gammaproteobacteria,1WZSR@135613|Chromatiales	135613|Chromatiales	M	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
CH3_k127_3668703_2	1266914.ATUK01000005_gene2608	2.098e-80	284.0	COG1075@1|root,COG1075@2|Bacteria,1R5PF@1224|Proteobacteria,1S87U@1236|Gammaproteobacteria,1WZUV@135613|Chromatiales	135613|Chromatiales	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF915,LCAT,PGAP1
CH3_k127_3695480_1	335543.Sfum_2226	7.447e-71	244.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,42MSV@68525|delta/epsilon subdivisions,2WJ6U@28221|Deltaproteobacteria,2MQCS@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Penicillin-Binding Protein C-terminus Family	pbp2	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
CH3_k127_3695480_0	686340.Metal_3962	1.894e-220	688.0	COG0362@1|root,COG0362@2|Bacteria,1MVV8@1224|Proteobacteria,1RM7P@1236|Gammaproteobacteria,1XDUV@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
CH3_k127_3727724_1	1192034.CAP_4132	2.32e-30	126.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2YX41@29|Myxococcales	28221|Deltaproteobacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
CH3_k127_3727724_0	349521.HCH_07028	1.1e-183	588.0	COG2373@1|root,COG3755@1|root,COG2373@2|Bacteria,COG3755@2|Bacteria,1MV7J@1224|Proteobacteria,1RNRY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,LprI,MG1
CH3_k127_3740174_3	697282.Mettu_0147	3.893e-114	380.0	COG0552@1|root,COG1612@1|root,COG0552@2|Bacteria,COG1612@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XE6A@135618|Methylococcales	135618|Methylococcales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	COX15-CtaA,SRP54,SRP54_N
CH3_k127_3740174_5	1116472.MGMO_15c00170	8e-57	204.0	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SI8Q@1236|Gammaproteobacteria,1XF11@135618|Methylococcales	135618|Methylococcales	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3740174_4	697282.Mettu_0145	1.666e-78	269.0	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1XEXY@135618|Methylococcales	135618|Methylococcales	S	SURF1-like protein	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
CH3_k127_3740174_6	697282.Mettu_0144	2.056e-18	89.0	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria,1XFSX@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2909)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2909
CH3_k127_3740174_2	697282.Mettu_0143	4.134e-152	484.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1XDSW@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
CH3_k127_3740174_0	697282.Mettu_0141	0.0	999.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1XEW1@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
CH3_k127_3740174_1	697282.Mettu_0140	6.204e-197	619.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XECZ@135618|Methylococcales	135618|Methylococcales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
CH3_k127_3761086_0	243233.MCA0593	1.324e-145	470.0	COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,1XENA@135618|Methylococcales	135618|Methylococcales	KLT	kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2,Pkinase
CH3_k127_3761086_3	323848.Nmul_A0947	3.207e-36	141.0	COG1733@1|root,COG1733@2|Bacteria,1N414@1224|Proteobacteria,2VV92@28216|Betaproteobacteria,373CB@32003|Nitrosomonadales	28216|Betaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
CH3_k127_3761086_1	1116472.MGMO_53c00100	6.507e-112	367.0	COG0625@1|root,COG0625@2|Bacteria,1MX33@1224|Proteobacteria,1S4KF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_6,GST_N_4
CH3_k127_3761086_2	448385.sce5397	7.298e-59	210.0	COG0625@1|root,COG0625@2|Bacteria,1RAIN@1224|Proteobacteria,431QU@68525|delta/epsilon subdivisions,2WX2X@28221|Deltaproteobacteria,2Z157@29|Myxococcales	28221|Deltaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
CH3_k127_3770146_2	351348.Maqu_3386	5.692e-118	383.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,465D4@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
CH3_k127_3770146_6	887898.HMPREF0551_2114	2.084e-12	67.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,2VHIR@28216|Betaproteobacteria,1K2EN@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
CH3_k127_3770146_3	887898.HMPREF0551_2114	2.55e-85	284.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,2VHIR@28216|Betaproteobacteria,1K2EN@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
CH3_k127_3770146_4	1304874.JAFY01000005_gene1444	5.949e-45	170.0	COG0610@1|root,COG0610@2|Bacteria,3TAA7@508458|Synergistetes	508458|Synergistetes	L	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
CH3_k127_3770146_0	857087.Metme_2615	0.0	1199.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,1RMG4@1236|Gammaproteobacteria,1XDRS@135618|Methylococcales	135618|Methylococcales	T	Carbon starvation protein CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
CH3_k127_3770146_5	857087.Metme_4332	3.676e-19	87.0	COG2730@1|root,COG2730@2|Bacteria,1RGQH@1224|Proteobacteria,1SZG0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	3.2.1.58	ko:K01210	ko00500,map00500	-	R00308,R03115	RC00467	ko00000,ko00001,ko01000	-	-	-	Cellulase
CH3_k127_3770146_1	697282.Mettu_3922	9.723e-141	453.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1XDRP@135618|Methylococcales	135618|Methylococcales	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
CH3_k127_3786697_11	177439.DP1198	4.633e-88	294.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,2MMQF@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,ELFV_dehydrog,ELFV_dehydrog_N
CH3_k127_3786697_10	535289.Dtpsy_2714	2.452e-88	298.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,4A9VK@80864|Comamonadaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
CH3_k127_3786697_22	82654.Pse7367_3858	1.254e-29	120.0	2E5G8@1|root,3307X@2|Bacteria	2|Bacteria	S	Immunity protein 53	-	-	-	-	-	-	-	-	-	-	-	-	Imm53
CH3_k127_3786697_20	118173.KB235914_gene2885	1.78e-40	156.0	2FEKE@1|root,346JV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3786697_14	1162668.LFE_1605	3.677e-63	220.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
CH3_k127_3786697_21	1095769.CAHF01000010_gene1338	4.028e-32	127.0	COG4274@1|root,COG4274@2|Bacteria,1RHJ3@1224|Proteobacteria,2VXBZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
CH3_k127_3786697_25	1144342.PMI40_02307	4.927e-20	93.0	COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,2VPK0@28216|Betaproteobacteria	28216|Betaproteobacteria	L	restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_N,Mrr_cat
CH3_k127_3786697_24	697282.Mettu_2909	1.047e-23	110.0	COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,1S3Z2@1236|Gammaproteobacteria,1XF0T@135618|Methylococcales	135618|Methylococcales	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CH3_k127_3786697_9	697282.Mettu_1129	1.766e-106	351.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1XDW2@135618|Methylococcales	135618|Methylococcales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
CH3_k127_3786697_5	857087.Metme_3757	1.316e-148	475.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1XDT9@135618|Methylococcales	135618|Methylococcales	K	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
CH3_k127_3786697_7	697282.Mettu_1842	5.959e-123	411.0	COG5607@1|root,COG5607@2|Bacteria,1R5I1@1224|Proteobacteria,1S0QK@1236|Gammaproteobacteria,1XEJ3@135618|Methylococcales	135618|Methylococcales	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
CH3_k127_3786697_16	686340.Metal_1700	2.895e-58	208.0	COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1XF5G@135618|Methylococcales	135618|Methylococcales	H	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway	ubiC	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.3.40	ko:K03181	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R01302	RC00491,RC02148	ko00000,ko00001,ko00002,ko01000	-	-	-	Chor_lyase
CH3_k127_3786697_2	697282.Mettu_2546	2.603e-286	894.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XE3Z@135618|Methylococcales	135618|Methylococcales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
CH3_k127_3786697_18	396588.Tgr7_3184	2.465e-56	201.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales	135613|Chromatiales	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CH3_k127_3786697_1	697282.Mettu_2548	0.0	1018.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1XE2K@135618|Methylococcales	135618|Methylococcales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
CH3_k127_3786697_23	857087.Metme_1672	6.532e-28	114.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1XFGX@135618|Methylococcales	135618|Methylococcales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
CH3_k127_3786697_3	697282.Mettu_1260	7.219e-228	712.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1XESK@135618|Methylococcales	135618|Methylococcales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
CH3_k127_3786697_0	697282.Mettu_2187	0.0	1354.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XEFJ@135618|Methylococcales	135618|Methylococcales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
CH3_k127_3786697_13	1116472.MGMO_66c00450	8.25e-64	219.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1XFBB@135618|Methylococcales	135618|Methylococcales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
CH3_k127_3786697_15	697282.Mettu_1307	9.71e-59	207.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1XF55@135618|Methylococcales	135618|Methylococcales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
CH3_k127_3786697_4	697282.Mettu_1308	6.514e-167	529.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XE7D@135618|Methylococcales	135618|Methylococcales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
CH3_k127_3786697_8	697282.Mettu_1309	6.799e-109	354.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1XETZ@135618|Methylococcales	135618|Methylococcales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CH3_k127_3786697_12	1116472.MGMO_66c00410	1.788e-71	242.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1XEXU@135618|Methylococcales	135618|Methylococcales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
CH3_k127_3786697_17	686340.Metal_3291	3.868e-57	200.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1XF6W@135618|Methylococcales	135618|Methylococcales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
CH3_k127_3786697_26	1049564.TevJSym_aa00230	2.944e-14	73.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,1SGC9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
CH3_k127_3786697_6	697282.Mettu_1313	3.913e-127	408.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1XE0M@135618|Methylococcales	135618|Methylococcales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
CH3_k127_3834031_9	697282.Mettu_3735	1.485e-52	188.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,1XFKC@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
CH3_k127_3834031_5	697282.Mettu_3734	5.546e-120	387.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1XDJG@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
CH3_k127_3834031_1	697282.Mettu_3733	0.0	1053.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1XDZJ@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
CH3_k127_3834031_8	697282.Mettu_3732	2.691e-56	201.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1XFC5@135618|Methylococcales	135618|Methylococcales	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CH3_k127_3834031_3	686340.Metal_1518	3.579e-230	718.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XER5@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
CH3_k127_3834031_0	697282.Mettu_3730	0.0	1337.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1XDTA@135618|Methylococcales	135618|Methylococcales	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
CH3_k127_3834031_4	697282.Mettu_3729	2.505e-176	558.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1XEDP@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
CH3_k127_3834031_6	697282.Mettu_3728	9.546e-108	349.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1XDQ1@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
CH3_k127_3834031_7	697282.Mettu_3727	1.111e-76	260.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1XF7Z@135618|Methylococcales	135618|Methylococcales	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
CH3_k127_3834031_10	697282.Mettu_3725	7.536e-49	176.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,1XFGF@135618|Methylococcales	135618|Methylococcales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
CH3_k127_3834031_2	697282.Mettu_3724	8.531e-274	853.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1XEVB@135618|Methylococcales	135618|Methylococcales	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
CH3_k127_3834031_11	686340.Metal_1511	6.545e-07	55.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1XE7J@135618|Methylococcales	135618|Methylococcales	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CH3_k127_3840467_1	715451.ambt_17675	1.657e-135	443.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1R97Q@1224|Proteobacteria,1RRDP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
CH3_k127_3840467_2	375286.mma_0692	1.552e-31	129.0	COG4574@1|root,COG4574@2|Bacteria,1MZEN@1224|Proteobacteria,2VUFF@28216|Betaproteobacteria,4773R@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Ecotin	eco	-	-	ko:K08276	-	-	-	-	ko00000	-	-	-	Ecotin
CH3_k127_3840467_5	290317.Cpha266_2522	0.0005378	48.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	ko:K03442,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.2,1.A.23.3	-	-	LysM,MS_channel,Mu-transpos_C,rve
CH3_k127_3840467_4	1121921.KB898706_gene2431	2.972e-19	89.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CH3_k127_3840467_0	697282.Mettu_4184	8.981e-305	937.0	2F6U8@1|root,33ZAC@2|Bacteria,1NYBF@1224|Proteobacteria,1THMC@1236|Gammaproteobacteria,1XEUE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3840467_3	686340.Metal_1959	1.84e-28	116.0	2AYI2@1|root,31QMN@2|Bacteria,1PW2J@1224|Proteobacteria,1TI31@1236|Gammaproteobacteria,1XGDU@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3840627_0	697282.Mettu_1833	1.285e-173	552.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1XDTR@135618|Methylococcales	135618|Methylococcales	G	alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CH3_k127_3840627_1	686340.Metal_1375	1.313e-154	492.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1XEDQ@135618|Methylococcales	135618|Methylococcales	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
CH3_k127_3840627_3	697282.Mettu_1592	3.043e-76	268.0	COG2433@1|root,COG2433@2|Bacteria,1N0ZS@1224|Proteobacteria,1S7FF@1236|Gammaproteobacteria,1XF02@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
CH3_k127_3840627_5	697282.Mettu_1590	1.693e-68	242.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1XF20@135618|Methylococcales	135618|Methylococcales	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
CH3_k127_3840627_2	686340.Metal_1372	1.712e-109	360.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1XEAB@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
CH3_k127_3840627_4	697282.Mettu_1584	7.684e-69	243.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1XG89@135618|Methylococcales	135618|Methylococcales	P	PFAM Regulator of K conductance, N-terminal	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,TrkA_N
CH3_k127_3886912_1	697282.Mettu_0493	1.171e-181	570.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1XEID@135618|Methylococcales	135618|Methylococcales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CH3_k127_3886912_7	697282.Mettu_0492	8.066e-19	91.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,1SAC6@1236|Gammaproteobacteria,1XFSH@135618|Methylococcales	135618|Methylococcales	C	succinate dehydrogenase, hydrophobic membrane anchor	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
CH3_k127_3886912_6	857087.Metme_2139	6.92e-30	122.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,1SBDX@1236|Gammaproteobacteria,1XFGY@135618|Methylococcales	135618|Methylococcales	C	Succinate dehydrogenase, cytochrome b556 subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
CH3_k127_3886912_5	1116472.MGMO_105c00250	1.862e-36	157.0	2C2C7@1|root,31ND2@2|Bacteria,1QK45@1224|Proteobacteria,1TI70@1236|Gammaproteobacteria,1XGNH@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3886912_4	1116472.MGMO_105c00620	6.198e-101	335.0	COG5501@1|root,COG5501@2|Bacteria,1PB0I@1224|Proteobacteria,1S435@1236|Gammaproteobacteria,1XDZ1@135618|Methylococcales	135618|Methylococcales	S	PFAM Sulphur oxidation protein SoxZ	-	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY,SoxZ
CH3_k127_3886912_2	1116472.MGMO_98c00010	1.805e-127	413.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1S0BJ@1236|Gammaproteobacteria,1XEGD@135618|Methylococcales	135618|Methylococcales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CH3_k127_3886912_8	876269.ARWA01000001_gene2414	0.0005938	46.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2TRMU@28211|Alphaproteobacteria,3NA2W@45404|Beijerinckiaceae	28211|Alphaproteobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
CH3_k127_3886912_3	697282.Mettu_1128	7.505e-124	402.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1XEBB@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
CH3_k127_3886912_0	697282.Mettu_3861	7.919e-209	655.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CH3_k127_3898938_3	686340.Metal_2263	2.888e-85	291.0	COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,1RMJK@1236|Gammaproteobacteria,1XE64@135618|Methylococcales	135618|Methylococcales	M	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus	-	-	-	ko:K07261	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M74
CH3_k127_3898938_4	686340.Metal_0082	1.75e-55	200.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1SD0V@1236|Gammaproteobacteria,1XFCG@135618|Methylococcales	135618|Methylococcales	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CH3_k127_3898938_6	1116472.MGMO_43c00270	2.328e-44	166.0	COG1051@1|root,COG1051@2|Bacteria,1QIBH@1224|Proteobacteria,1TG5S@1236|Gammaproteobacteria,1XFR5@135618|Methylococcales	135618|Methylococcales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CH3_k127_3898938_2	697282.Mettu_4049	4.574e-145	480.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1XED4@135618|Methylococcales	135618|Methylococcales	S	Putative peptidoglycan binding domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
CH3_k127_3898938_7	686340.Metal_1803	2.064e-25	109.0	COG2913@1|root,COG2913@2|Bacteria,1N44J@1224|Proteobacteria,1SSX3@1236|Gammaproteobacteria,1XFT2@135618|Methylococcales	135618|Methylococcales	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3898938_5	697282.Mettu_1510	7.005e-46	172.0	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,1SB0K@1236|Gammaproteobacteria,1XFA1@135618|Methylococcales	135618|Methylococcales	C	hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_3898938_0	697282.Mettu_1511	2.416e-289	892.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1XDSA@135618|Methylococcales	135618|Methylococcales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
CH3_k127_3898938_1	1116472.MGMO_20c00320	5.27e-165	541.0	COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1XDQA@135618|Methylococcales	135618|Methylococcales	S	exporter	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
CH3_k127_3899340_0	857087.Metme_3296	0.0	1829.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1XE54@135618|Methylococcales	135618|Methylococcales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CH3_k127_3968387_1	697282.Mettu_1125	1.994e-105	348.0	COG1058@1|root,COG1058@2|Bacteria,1QUB2@1224|Proteobacteria,1RNXG@1236|Gammaproteobacteria,1XDQY@135618|Methylococcales	135618|Methylococcales	S	Belongs to the CinA family	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
CH3_k127_3968387_0	686340.Metal_0194	4.214e-120	393.0	COG0679@1|root,COG0679@2|Bacteria,1RCAI@1224|Proteobacteria,1S2TH@1236|Gammaproteobacteria,1XEVE@135618|Methylococcales	135618|Methylococcales	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
CH3_k127_3968387_2	243233.MCA0092	1.714e-94	318.0	COG2933@1|root,COG2933@2|Bacteria,1MWBM@1224|Proteobacteria,1RMSB@1236|Gammaproteobacteria,1XGD5@135618|Methylococcales	135618|Methylococcales	J	FtsJ-like methyltransferase	-	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
CH3_k127_3980237_4	697282.Mettu_3241	5.035e-24	103.0	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,1SFGZ@1236|Gammaproteobacteria,1XFNP@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
CH3_k127_3980237_3	857087.Metme_4011	2.96e-31	125.0	COG2863@1|root,COG2863@2|Bacteria,1QI9P@1224|Proteobacteria,1TG3P@1236|Gammaproteobacteria,1XFFX@135618|Methylococcales	135618|Methylococcales	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
CH3_k127_3980237_0	857087.Metme_4012	1.265e-281	871.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,1RR3N@1236|Gammaproteobacteria,1XDIJ@135618|Methylococcales	135618|Methylococcales	C	PFAM Cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
CH3_k127_3980237_2	686340.Metal_2006	1.144e-34	135.0	arCOG08720@1|root,3320J@2|Bacteria,1N97H@1224|Proteobacteria,1SDTQ@1236|Gammaproteobacteria,1XFI0@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF2024)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2024
CH3_k127_3980237_1	697282.Mettu_2801	4.337e-72	248.0	COG1846@1|root,COG1846@2|Bacteria,1MZS9@1224|Proteobacteria,1SBPM@1236|Gammaproteobacteria,1XEZD@135618|Methylococcales	135618|Methylococcales	K	PFAM HTH transcriptional regulator, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CH3_k127_4025119_1	1116472.MGMO_45c00320	4.062e-70	243.0	COG0577@1|root,COG0577@2|Bacteria,1PJZX@1224|Proteobacteria,1RU56@1236|Gammaproteobacteria,1XDTW@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CH3_k127_4025119_0	857087.Metme_3932	2.867e-84	282.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RSA2@1236|Gammaproteobacteria,1XEQX@135618|Methylococcales	135618|Methylococcales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_4076914_0	697282.Mettu_3865	2.09e-223	701.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1XER4@135618|Methylococcales	135618|Methylococcales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CH3_k127_4094069_16	426355.Mrad2831_2367	0.0007	43.0	COG1835@1|root,COG1835@2|Bacteria,1R6TT@1224|Proteobacteria,2TT2X@28211|Alphaproteobacteria,1JYWK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
CH3_k127_4094069_8	545243.BAEV01000056_gene207	5.101e-64	235.0	COG0438@1|root,COG0438@2|Bacteria,1V0JW@1239|Firmicutes,24CKB@186801|Clostridia,36I9R@31979|Clostridiaceae	186801|Clostridia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CH3_k127_4094069_11	266779.Meso_2585	1.374e-29	128.0	COG2303@1|root,COG2303@2|Bacteria,1MXUT@1224|Proteobacteria,2V986@28211|Alphaproteobacteria,43JT4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
CH3_k127_4094069_13	622637.KE124774_gene2318	2.313e-12	67.0	COG1216@1|root,COG1216@2|Bacteria,1RAM8@1224|Proteobacteria,2U5N6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Glyco_tranf_2_3,Glycos_transf_2
CH3_k127_4094069_9	573065.Astex_2217	6.673e-35	136.0	COG1442@1|root,COG1442@2|Bacteria,1MZZ2@1224|Proteobacteria,2UDCM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
CH3_k127_4094069_15	573065.Astex_2217	2.488e-11	66.0	COG1442@1|root,COG1442@2|Bacteria,1MZZ2@1224|Proteobacteria,2UDCM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
CH3_k127_4094069_3	697282.Mettu_2065	1.103e-192	614.0	COG1008@1|root,COG1008@2|Bacteria,1R8V8@1224|Proteobacteria,1RZVG@1236|Gammaproteobacteria,1XEIN@135618|Methylococcales	135618|Methylococcales	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CH3_k127_4094069_5	697282.Mettu_2064	6.129e-181	580.0	COG1008@1|root,COG1008@2|Bacteria,1R6UV@1224|Proteobacteria,1S0HQ@1236|Gammaproteobacteria,1XEP1@135618|Methylococcales	135618|Methylococcales	C	overlaps another CDS with the same product name	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CH3_k127_4094069_4	1288494.EBAPG3_18850	4.772e-187	598.0	COG1009@1|root,COG1009@2|Bacteria,1R5G2@1224|Proteobacteria,2VZ5Y@28216|Betaproteobacteria,373B7@32003|Nitrosomonadales	28216|Betaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M,Proton_antipo_N
CH3_k127_4094069_0	697282.Mettu_2060	0.0	1225.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,1XEJM@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
CH3_k127_4094069_2	1288494.EBAPG3_21310	3.35e-201	638.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2W13F@28216|Betaproteobacteria,3740B@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
CH3_k127_4094069_1	857087.Metme_0521	1.53e-230	726.0	COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,1RRCQ@1236|Gammaproteobacteria,1XDYU@135618|Methylococcales	135618|Methylococcales	P	PFAM Sulfate transporter family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfate_transp
CH3_k127_4094069_12	697282.Mettu_0450	2.196e-22	99.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RQTW@1236|Gammaproteobacteria,1XGCS@135618|Methylococcales	1236|Gammaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
CH3_k127_4094069_6	261292.Nit79A3_0155	7.951e-166	529.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2WADG@28216|Betaproteobacteria,374FC@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF772
CH3_k127_4094069_14	1288494.EBAPG3_15580	4.038e-12	72.0	29FX1@1|root,32CHZ@2|Bacteria,1PW6D@1224|Proteobacteria,2WBRE@28216|Betaproteobacteria,373NN@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_4094069_7	857087.Metme_0522	6.283e-101	332.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,1XDVX@135618|Methylococcales	135618|Methylococcales	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
CH3_k127_4094069_10	1116472.MGMO_125c00050	4.316e-30	121.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,1RYIX@1236|Gammaproteobacteria,1XEXF@135618|Methylococcales	135618|Methylococcales	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CH3_k127_4173552_16	857087.Metme_4516	1.052e-28	115.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1XDUP@135618|Methylococcales	135618|Methylococcales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
CH3_k127_4173552_12	1116472.MGMO_20c00070	8.269e-72	251.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1XEXV@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
CH3_k127_4173552_20	697282.Mettu_1746	0.0001411	45.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,1S4TE@1236|Gammaproteobacteria,1XETM@135618|Methylococcales	135618|Methylococcales	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
CH3_k127_4173552_4	697282.Mettu_2145	1.659e-121	394.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1XDZ7@135618|Methylococcales	135618|Methylococcales	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CH3_k127_4173552_5	1116472.MGMO_20c00040	1.371e-120	392.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1XE9B@135618|Methylococcales	135618|Methylococcales	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	Crp,ParBc
CH3_k127_4173552_1	686340.Metal_3211	2.033e-239	749.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1XDQT@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
CH3_k127_4173552_17	671143.DAMO_1959	6.477e-23	100.0	COG4314@1|root,COG4314@2|Bacteria	2|Bacteria	C	lipoprotein involved in nitrous oxide reduction	-	-	-	-	-	-	-	-	-	-	-	-	NosL
CH3_k127_4173552_19	1408418.JNJH01000060_gene1186	1.864e-16	82.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria	1224|Proteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
CH3_k127_4173552_15	857087.Metme_2054	4.762e-35	138.0	COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1SE25@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	BLUF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
CH3_k127_4173552_3	1163617.SCD_n01273	1.575e-121	403.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria	28216|Betaproteobacteria	H	MoeA domain protein domain I and II	moeA1	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
CH3_k127_4173552_6	1123228.AUIH01000004_gene1085	1.991e-116	380.0	COG1975@1|root,COG1975@2|Bacteria,1MWFN@1224|Proteobacteria,1RV4F@1236|Gammaproteobacteria,1XQ7H@135619|Oceanospirillales	135619|Oceanospirillales	O	XdhC Rossmann domain	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_C,XdhC_CoxI
CH3_k127_4173552_13	1123228.AUIH01000004_gene1086	7.449e-64	225.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria	1224|Proteobacteria	H	MobA-Related Protein	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CH3_k127_4173552_9	1123228.AUIH01000004_gene1087	4.635e-99	334.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,1MWFN@1224|Proteobacteria,1RV4F@1236|Gammaproteobacteria,1XQ7H@135619|Oceanospirillales	135619|Oceanospirillales	O	XdhC Rossmann domain	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_C,XdhC_CoxI
CH3_k127_4173552_8	1123228.AUIH01000004_gene1088	4.099e-108	362.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,1RZ5Y@1236|Gammaproteobacteria,1XJEQ@135619|Oceanospirillales	135619|Oceanospirillales	S	COG3552 Protein containing von Willebrand factor type A (vWA) domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
CH3_k127_4173552_2	1123228.AUIH01000004_gene1089	3.704e-122	398.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,1RZDH@1236|Gammaproteobacteria,1XIX3@135619|Oceanospirillales	135619|Oceanospirillales	S	ATPase, AAA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
CH3_k127_4173552_14	1123228.AUIH01000004_gene1090	3.561e-54	197.0	COG3427@1|root,COG3427@2|Bacteria,1PJ51@1224|Proteobacteria,1SGFU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	-	-	-	-	-	-	-	-	-	COXG
CH3_k127_4173552_0	1123228.AUIH01000004_gene1091	0.0	1247.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1XRUQ@135619|Oceanospirillales	135619|Oceanospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4,1.3.99.8	ko:K11177,ko:K16877	ko00230,ko00365,ko01100,ko01120,map00230,map00365,map01100,map01120	M00546	R01768,R02103,R02987	RC00143,RC01856	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
CH3_k127_4173552_11	1158292.JPOE01000002_gene2283	5.157e-76	258.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ75@28216|Betaproteobacteria,1KNM2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CH3_k127_4173552_7	1123228.AUIH01000004_gene1093	3.443e-109	360.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,1RYJY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	carbon monoxide dehydrogenase	-	-	1.2.5.3,1.3.99.8	ko:K03519,ko:K16878	ko00365,ko01120,map00365,map01120	-	R02987,R11168	RC01856,RC02800	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CH3_k127_4173552_10	243233.MCA0805	3.84e-82	278.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XE6F@135618|Methylococcales	135618|Methylococcales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CH3_k127_4173552_18	686340.Metal_0796	1.176e-20	94.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XE6F@135618|Methylococcales	135618|Methylococcales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CH3_k127_4218446_1	857087.Metme_2212	2.199e-79	270.0	2CNUX@1|root,32SHU@2|Bacteria,1REYT@1224|Proteobacteria,1S2ZX@1236|Gammaproteobacteria,1XDUI@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF2760)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2760
CH3_k127_4218446_0	697282.Mettu_3235	3.914e-315	975.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RQ12@1236|Gammaproteobacteria,1XDZB@135618|Methylococcales	135618|Methylococcales	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
CH3_k127_4239020_1	1163617.SCD_n01945	1.248e-71	252.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
CH3_k127_4239020_3	857087.Metme_2216	2.133e-13	76.0	2AW80@1|root,31N39@2|Bacteria,1QJUT@1224|Proteobacteria,1THW9@1236|Gammaproteobacteria,1XFVI@135618|Methylococcales	135618|Methylococcales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
CH3_k127_4239020_0	857087.Metme_2360	4.809e-247	769.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
CH3_k127_4239020_2	715451.ambt_10600	2.303e-42	168.0	2DV2C@1|root,33TPD@2|Bacteria,1PAUI@1224|Proteobacteria	1224|Proteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
CH3_k127_4255630_3	857087.Metme_0605	1.107e-99	326.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1XDTI@135618|Methylococcales	135618|Methylococcales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CH3_k127_4255630_2	857087.Metme_0606	3.766e-128	415.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1XDKH@135618|Methylococcales	135618|Methylococcales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
CH3_k127_4255630_1	697282.Mettu_0891	1.279e-150	481.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1XDUU@135618|Methylococcales	135618|Methylococcales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CH3_k127_4255630_0	697282.Mettu_0892	2.064e-174	556.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1XEPM@135618|Methylococcales	135618|Methylococcales	H	PFAM Mur ligase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
CH3_k127_4255630_4	1116472.MGMO_126c00240	2.044e-10	66.0	COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1XFK1@135618|Methylococcales	135618|Methylococcales	S	Sporulation related domain	-	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
CH3_k127_4257919_1	1116472.MGMO_163c00010	6.714e-125	408.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1XEKH@135618|Methylococcales	135618|Methylococcales	L	Bacterial DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
CH3_k127_4257919_0	697282.Mettu_0413	4.714e-218	687.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1XEKR@135618|Methylococcales	135618|Methylococcales	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
CH3_k127_4257919_2	1116472.MGMO_53c00430	4.771e-55	205.0	COG4796@1|root,COG4796@2|Bacteria,1RCNA@1224|Proteobacteria,1SE5I@1236|Gammaproteobacteria,1XFB4@135618|Methylococcales	135618|Methylococcales	U	Belongs to the GSP D family	-	-	-	-	-	-	-	-	-	-	-	-	Secretin
CH3_k127_4259958_2	857087.Metme_3568	2.087e-79	271.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria,1XEZ0@135618|Methylococcales	135618|Methylococcales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CH3_k127_4259958_0	857087.Metme_4289	1.574e-145	470.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1XEK6@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Radical_SAM
CH3_k127_4259958_1	697282.Mettu_4008	1.616e-84	289.0	292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,1S44V@1236|Gammaproteobacteria,1XF22@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
CH3_k127_4259958_3	697282.Mettu_4009	3.332e-21	94.0	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,1SA94@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CH3_k127_4299399_2	697282.Mettu_3664	2.284e-25	106.0	COG1716@1|root,COG1716@2|Bacteria,1PGN8@1224|Proteobacteria,1SEK2@1236|Gammaproteobacteria,1XFDB@135618|Methylococcales	135618|Methylococcales	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
CH3_k127_4299399_0	857087.Metme_2961	5.711e-182	578.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1XEF5@135618|Methylococcales	135618|Methylococcales	P	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CH3_k127_4299399_1	697282.Mettu_1125	8.183e-35	139.0	COG1058@1|root,COG1058@2|Bacteria,1QUB2@1224|Proteobacteria,1RNXG@1236|Gammaproteobacteria,1XDQY@135618|Methylococcales	135618|Methylococcales	S	Belongs to the CinA family	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
CH3_k127_4339836_3	1123392.AQWL01000001_gene1676	1.57e-08	58.0	COG0210@1|root,COG0210@2|Bacteria,1MWW6@1224|Proteobacteria,2VM7D@28216|Betaproteobacteria,1KTI1@119069|Hydrogenophilales	119069|Hydrogenophilales	L	UvrD-like helicase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	UvrD_C
CH3_k127_4339836_0	1116472.MGMO_84c00070	1.146e-85	291.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales	135618|Methylococcales	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
CH3_k127_4339836_4	1547437.LL06_13815	0.000601	43.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,2U77K@28211|Alphaproteobacteria,43JNP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
CH3_k127_4339836_2	572477.Alvin_2131	1.897e-22	97.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
CH3_k127_4339836_1	243233.MCA1827	5.38e-40	154.0	2E3RZ@1|root,32YPK@2|Bacteria,1NJYT@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_4387754_0	686340.Metal_0913	1.515e-76	259.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1XENU@135618|Methylococcales	135618|Methylococcales	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CH3_k127_4387754_1	1116472.MGMO_71c00020	1.229e-49	185.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,1RS5K@1236|Gammaproteobacteria,1XF6A@135618|Methylococcales	135618|Methylococcales	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
CH3_k127_4387754_2	686340.Metal_2570	1.544e-07	53.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1XE7A@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CH3_k127_4393522_3	697282.Mettu_4044	2.508e-89	310.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales	135618|Methylococcales	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
CH3_k127_4393522_1	1137799.GZ78_21805	5.088e-105	347.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1XH8W@135619|Oceanospirillales	135619|Oceanospirillales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
CH3_k127_4393522_0	697282.Mettu_0742	5.959e-134	442.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1XEHX@135618|Methylococcales	135618|Methylococcales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
CH3_k127_4393522_4	686340.Metal_2522	4.047e-77	266.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1XDJA@135618|Methylococcales	135618|Methylococcales	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CH3_k127_4393522_2	697282.Mettu_0744	2.559e-94	314.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1XDWI@135618|Methylococcales	135618|Methylococcales	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_4424698_0	697282.Mettu_2483	6.309e-189	596.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1XEW0@135618|Methylococcales	135618|Methylococcales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
CH3_k127_4424698_2	697282.Mettu_2484	5.041e-41	153.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1XFKJ@135618|Methylococcales	135618|Methylococcales	J	Sigma 54 modulation protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
CH3_k127_4424698_1	1116472.MGMO_55c00170	1.048e-137	442.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1XE9S@135618|Methylococcales	135618|Methylococcales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
CH3_k127_4529231_1	243233.MCA0769	2.688e-128	412.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales	135618|Methylococcales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
CH3_k127_4529231_0	243233.MCA0768	7.018e-140	451.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria,1XDK5@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
CH3_k127_4558808_2	697282.Mettu_4043	1.584e-41	156.0	COG1366@1|root,COG1366@2|Bacteria,1N6U1@1224|Proteobacteria,1SJ1P@1236|Gammaproteobacteria,1XFIF@135618|Methylococcales	135618|Methylococcales	T	PFAM Sulphate transporter antisigma-factor antagonist STAS	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CH3_k127_4558808_0	697282.Mettu_4042	6.41e-57	201.0	COG2172@1|root,COG2172@2|Bacteria,1RKVT@1224|Proteobacteria,1SAGT@1236|Gammaproteobacteria,1XF5C@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
CH3_k127_4558808_1	697282.Mettu_4041	3.077e-43	167.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1XEA1@135618|Methylococcales	135618|Methylococcales	E	PFAM Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
CH3_k127_4578608_1	1249627.D779_3440	3.482e-68	240.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1WWKF@135613|Chromatiales	135613|Chromatiales	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
CH3_k127_4578608_4	1120963.KB894491_gene1107	3.779e-07	53.0	2DE24@1|root,2ZK69@2|Bacteria,1P9N5@1224|Proteobacteria,1SU0Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_4578608_2	697282.Mettu_0090	3.114e-66	229.0	COG0517@1|root,COG0517@2|Bacteria,1N0EB@1224|Proteobacteria,1SYB8@1236|Gammaproteobacteria,1XGD2@135618|Methylococcales	135618|Methylococcales	S	PFAM Cystathionine beta-synthase, core	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
CH3_k127_4578608_0	697282.Mettu_0091	1.191e-101	334.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1XEGI@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
CH3_k127_4578608_3	686340.Metal_2641	1.083e-62	218.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1XEMR@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
CH3_k127_4583997_1	857087.Metme_2794	3.5e-127	431.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1XEQ0@135618|Methylococcales	135618|Methylococcales	NU	type II III secretion system	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
CH3_k127_4583997_0	1116472.MGMO_53c00870	0.0	1064.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1XDJY@135618|Methylococcales	135618|Methylococcales	E	Peptidase family M3	prlC	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
CH3_k127_4583997_2	857087.Metme_3440	7.807e-86	291.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,1XEIQ@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
CH3_k127_4605872_1	686340.Metal_0404	2.354e-209	657.0	COG1029@1|root,COG1029@2|Bacteria,1R64R@1224|Proteobacteria,1RNM2@1236|Gammaproteobacteria,1XDZR@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM formylmethanofuran dehydrogenase subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	-
CH3_k127_4605872_0	686340.Metal_0405	0.0	999.0	COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,1RZ5G@1236|Gammaproteobacteria,1XDSE@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Formylmethanofuran dehydrogenase, subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
CH3_k127_4605872_2	631454.N177_1124	1.362e-57	201.0	COG1479@1|root,COG3472@1|root,COG1479@2|Bacteria,COG3472@2|Bacteria,1R5X1@1224|Proteobacteria,2TVAG@28211|Alphaproteobacteria,1JQGC@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,DUF1524,DUF262
CH3_k127_4609578_0	1116472.MGMO_16c00020	0.0	4426.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1XDIT@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
CH3_k127_4627280_1	686340.Metal_1316	1.059e-78	265.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1XF0N@135618|Methylococcales	135618|Methylococcales	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
CH3_k127_4627280_0	697282.Mettu_3014	1.562e-210	662.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1XE0D@135618|Methylococcales	135618|Methylococcales	U	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
CH3_k127_4627280_3	1116472.MGMO_101c00070	2.785e-63	223.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1XF3E@135618|Methylococcales	135618|Methylococcales	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
CH3_k127_4627280_6	349124.Hhal_1483	4.667e-27	113.0	COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0125 (RnfH) family	yfjF	-	-	ko:K09801	-	-	-	-	ko00000	-	-	-	Ub-RnfH
CH3_k127_4627280_4	857087.Metme_2237	2.032e-51	192.0	COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,1SCTT@1236|Gammaproteobacteria,1XF8G@135618|Methylococcales	135618|Methylococcales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamE	-	-	ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	SmpA_OmlA
CH3_k127_4627280_2	686340.Metal_1310	1.603e-66	228.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,1XF3C@135618|Methylococcales	135618|Methylococcales	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CH3_k127_4627280_5	857087.Metme_2239	2.288e-45	168.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1XE02@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
CH3_k127_4639730_6	857087.Metme_4127	4.335e-32	126.0	COG0547@1|root,COG0547@2|Bacteria,1QJ8Q@1224|Proteobacteria,1RY26@1236|Gammaproteobacteria,1XEPN@135618|Methylococcales	135618|Methylococcales	E	PFAM Glycosyl transferase, family	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_trans_3N,Glycos_transf_3
CH3_k127_4639730_2	768671.ThimaDRAFT_2831	1.247e-98	324.0	COG0288@1|root,COG0288@2|Bacteria,1R3SC@1224|Proteobacteria,1RRB4@1236|Gammaproteobacteria,1WXB8@135613|Chromatiales	135613|Chromatiales	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
CH3_k127_4639730_0	697282.Mettu_3833	1.307e-128	418.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1S524@1236|Gammaproteobacteria,1XE6I@135618|Methylococcales	135618|Methylococcales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CH3_k127_4639730_4	686340.Metal_3534	2.837e-40	152.0	2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,1SS3S@1236|Gammaproteobacteria,1XGXJ@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
CH3_k127_4639730_7	1116472.MGMO_79c00110	7.657e-29	118.0	2AUUS@1|root,31KHZ@2|Bacteria,1QID8@1224|Proteobacteria,1TG7I@1236|Gammaproteobacteria,1XFV7@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_4639730_3	857087.Metme_4130	8.403e-66	228.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,1XF7W@135618|Methylococcales	135618|Methylococcales	M	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
CH3_k127_4639730_8	1415779.JOMH01000001_gene809	3.97e-06	49.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
CH3_k127_4639730_5	1454004.AW11_02613	3.218e-35	138.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
CH3_k127_4639730_1	686340.Metal_0923	1.164e-109	363.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1XF7M@135618|Methylococcales	135618|Methylococcales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
CH3_k127_4688227_4	945713.IALB_0192	1.753e-22	108.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CH3_k127_4688227_7	349124.Hhal_2340	3.778e-08	56.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CH3_k127_4688227_5	243233.MCA1704	2.154e-22	98.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1XER9@135618|Methylococcales	135618|Methylococcales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CH3_k127_4688227_1	882378.RBRH_01486	1.425e-110	365.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,1K0EM@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CH3_k127_4688227_6	1116472.MGMO_52c00090	1.627e-10	66.0	COG0220@1|root,COG0220@2|Bacteria,1QZB6@1224|Proteobacteria,1T52W@1236|Gammaproteobacteria,1XEH1@135618|Methylococcales	135618|Methylococcales	J	tRNA (guanine-N7-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_4688227_2	243233.MCA1564	2.982e-93	320.0	2DM5E@1|root,31SVN@2|Bacteria,1MYKR@1224|Proteobacteria,1SF2N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
CH3_k127_4688227_0	243233.MCA1563	1.889e-266	833.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria,1XG2H@135618|Methylococcales	135618|Methylococcales	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
CH3_k127_4688227_3	243233.MCA1562	6.158e-28	113.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1XG0J@135618|Methylococcales	135618|Methylococcales	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
CH3_k127_4749007_1	1158756.AQXQ01000012_gene1642	5.631e-76	269.0	COG1075@1|root,COG1075@2|Bacteria,1R5PF@1224|Proteobacteria,1S87U@1236|Gammaproteobacteria,1WZUV@135613|Chromatiales	135613|Chromatiales	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF915,LCAT,PGAP1
CH3_k127_4749007_3	1121405.dsmv_3797	1.383e-13	72.0	COG4467@1|root,COG4467@2|Bacteria,1QW8C@1224|Proteobacteria	1224|Proteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
CH3_k127_4749007_4	1042377.AFPJ01000004_gene394	5.702e-06	51.0	COG3659@1|root,COG3659@2|Bacteria,1N12D@1224|Proteobacteria	1224|Proteobacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
CH3_k127_4749007_2	485913.Krac_0321	1.722e-43	161.0	COG0121@1|root,COG0121@2|Bacteria	2|Bacteria	S	cellular modified histidine biosynthetic process	egtC	-	-	-	-	-	-	-	-	-	-	-	GATase_4,GATase_6
CH3_k127_4749007_0	240292.Ava_4113	1.104e-123	403.0	COG2170@1|root,COG2170@2|Bacteria,1G6F1@1117|Cyanobacteria,1HPDI@1161|Nostocales	1117|Cyanobacteria	F	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
CH3_k127_476064_2	1116472.MGMO_54c00080	1.211e-121	394.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,1RNSP@1236|Gammaproteobacteria,1XEIP@135618|Methylococcales	135618|Methylococcales	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CH3_k127_476064_3	1116472.MGMO_54c00090	5.124e-43	162.0	COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,1SASF@1236|Gammaproteobacteria,1XFJZ@135618|Methylococcales	135618|Methylococcales	I	COG0575 CDP-diglyceride synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CarS-like
CH3_k127_476064_5	1288494.EBAPG3_14490	9.708e-31	125.0	2EAWF@1|root,334XP@2|Bacteria,1NKSU@1224|Proteobacteria,2WBUR@28216|Betaproteobacteria,373I4@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_476064_4	261292.Nit79A3_2170	7.734e-34	137.0	COG0607@1|root,COG0607@2|Bacteria,1NM25@1224|Proteobacteria	1224|Proteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CH3_k127_476064_1	686340.Metal_3904	7.746e-144	466.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1XG9U@135618|Methylococcales	135618|Methylococcales	D	AFG1-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AFG1_ATPase
CH3_k127_476064_0	243233.MCA0844	3.656e-158	502.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1XG5Y@135618|Methylococcales	135618|Methylococcales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
CH3_k127_476064_6	1123392.AQWL01000002_gene1981	0.0005081	44.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1KSU5@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
CH3_k127_477065_0	686340.Metal_2496	4.551e-108	352.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1XE4F@135618|Methylococcales	135618|Methylococcales	NU	Type II/IV secretion system protein	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CH3_k127_477065_1	697282.Mettu_2654	1.36e-94	318.0	COG0739@1|root,COG0739@2|Bacteria,1RIS0@1224|Proteobacteria,1S6KP@1236|Gammaproteobacteria,1XG3T@135618|Methylococcales	135618|Methylococcales	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CH3_k127_4798233_1	697282.Mettu_1303	1.335e-120	394.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XEEP@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
CH3_k127_4798233_0	1283300.ATXB01000001_gene2374	1.056e-199	631.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1XE0F@135618|Methylococcales	135618|Methylococcales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
CH3_k127_4798233_2	857087.Metme_2765	2.472e-47	175.0	COG1716@1|root,COG1716@2|Bacteria,1PGN8@1224|Proteobacteria,1SEK2@1236|Gammaproteobacteria,1XFDB@135618|Methylococcales	135618|Methylococcales	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
CH3_k127_4820890_5	857087.Metme_0818	8.326e-05	45.0	COG3416@1|root,COG3416@2|Bacteria,1PWXI@1224|Proteobacteria,1SEV4@1236|Gammaproteobacteria,1XGIU@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized protein conserved in bacteria (DUF2076)	-	-	-	ko:K09945	-	-	-	-	ko00000	-	-	-	DUF2076
CH3_k127_4820890_4	1116472.MGMO_85c00160	8.595e-18	85.0	2DN5Z@1|root,32VR7@2|Bacteria,1RI34@1224|Proteobacteria,1T3FH@1236|Gammaproteobacteria,1XDWT@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
CH3_k127_4820890_2	697282.Mettu_2848	3.925e-82	274.0	2DN5Z@1|root,32VR7@2|Bacteria,1RI34@1224|Proteobacteria,1T3FH@1236|Gammaproteobacteria,1XDWT@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
CH3_k127_4820890_0	243233.MCA2119	1.712e-238	745.0	COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1XG1U@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
CH3_k127_4820890_1	765913.ThidrDRAFT_3275	8.481e-134	432.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
CH3_k127_4820890_3	472759.Nhal_2543	4.008e-32	125.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
CH3_k127_487681_0	1116472.MGMO_10c00120	9.287e-147	475.0	28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria,1S6NY@1236|Gammaproteobacteria,1XG9N@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_496864_0	686340.Metal_3224	3.073e-121	398.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1XE3U@135618|Methylococcales	135618|Methylococcales	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CH3_k127_496864_2	686340.Metal_3225	1.777e-44	163.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1XFIW@135618|Methylococcales	135618|Methylococcales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
CH3_k127_496864_4	470.IX87_21230	7.274e-08	57.0	2DMWM@1|root,32U4H@2|Bacteria,1N2SS@1224|Proteobacteria,1S9T8@1236|Gammaproteobacteria,3NMPG@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	Z012_00645	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_496864_1	1116472.MGMO_172c00070	2.361e-54	194.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria,1XEI0@135618|Methylococcales	135618|Methylococcales	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CH3_k127_496864_3	1538295.JY96_09795	5.865e-25	107.0	COG2197@1|root,COG2197@2|Bacteria,1RGXD@1224|Proteobacteria,2WEGP@28216|Betaproteobacteria,1KIYQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CH3_k127_4989071_10	388051.AUFE01000031_gene3601	1.906e-37	152.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2VKTY@28216|Betaproteobacteria,1K11H@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
CH3_k127_4989071_11	314345.SPV1_09133	2.145e-24	111.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CH3_k127_4989071_1	756272.Plabr_3020	1.567e-238	742.0	COG1156@1|root,COG1156@2|Bacteria,2J2EX@203682|Planctomycetes	203682|Planctomycetes	C	ATP synthase alpha/beta family, beta-barrel domain	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
CH3_k127_4989071_6	756272.Plabr_3019	1.939e-66	232.0	COG1394@1|root,COG1394@2|Bacteria,2J3Y9@203682|Planctomycetes	203682|Planctomycetes	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
CH3_k127_4989071_3	756272.Plabr_3018	3.743e-171	555.0	COG1269@1|root,COG1269@2|Bacteria,2J3SY@203682|Planctomycetes	203682|Planctomycetes	U	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
CH3_k127_4989071_7	756272.Plabr_3017	1.223e-59	209.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
CH3_k127_4989071_8	756272.Plabr_3016	2.964e-58	210.0	COG1390@1|root,COG1390@2|Bacteria,2J4IC@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
CH3_k127_4989071_9	102129.Lepto7375DRAFT_2666	1.91e-45	172.0	28P4X@1|root,2ZC02@2|Bacteria,1G5WW@1117|Cyanobacteria,1HD6F@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2764)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2764
CH3_k127_4989071_0	765913.ThidrDRAFT_3270	5.343e-246	772.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WWAZ@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
CH3_k127_4989071_4	1210884.HG799469_gene14124	3.016e-134	433.0	COG2326@1|root,COG2326@2|Bacteria,2IYWN@203682|Planctomycetes	203682|Planctomycetes	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
CH3_k127_4989071_2	1041139.KB902624_gene5814	1.229e-224	708.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,4B93F@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sulfate permease and related transporters (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
CH3_k127_4989071_5	1123059.KB823011_gene909	2.148e-73	263.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2TQME@28211|Alphaproteobacteria,43XB5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
CH3_k127_5007186_2	1071679.BG57_32375	2.283e-05	49.0	COG0385@1|root,COG0385@2|Bacteria,1N9IH@1224|Proteobacteria,2WCHZ@28216|Betaproteobacteria,1K6KU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bile acid	-	-	-	-	-	-	-	-	-	-	-	-	SBF
CH3_k127_5007186_1	326297.Sama_2469	5.608e-23	108.0	2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria,2QA0N@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
CH3_k127_5007186_0	1116472.MGMO_42c00080	1.559e-230	717.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1XDMJ@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase, class I	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
CH3_k127_5030161_5	857087.Metme_0188	3.897e-39	149.0	2DPP8@1|root,332V3@2|Bacteria,1NJM6@1224|Proteobacteria,1SIP1@1236|Gammaproteobacteria,1XFGW@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3240
CH3_k127_5030161_0	697282.Mettu_2025	0.0	1562.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XEBY@135618|Methylococcales	135618|Methylococcales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
CH3_k127_5030161_3	697282.Mettu_2023	2.413e-110	369.0	COG0845@1|root,COG0845@2|Bacteria,1QN99@1224|Proteobacteria,1S0F7@1236|Gammaproteobacteria,1XEEX@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CH3_k127_5030161_2	857087.Metme_0191	1.415e-115	386.0	COG1538@1|root,COG1538@2|Bacteria,1RDXS@1224|Proteobacteria,1SZYV@1236|Gammaproteobacteria,1XEDE@135618|Methylococcales	135618|Methylococcales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CH3_k127_5030161_4	697282.Mettu_2019	3.782e-99	334.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,1SAIV@1236|Gammaproteobacteria,1XF44@135618|Methylococcales	135618|Methylococcales	S	PFAM Mitochondrial inner membrane translocase complex, subunit Tim44-related	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
CH3_k127_5030161_1	1116472.MGMO_10c00030	3.637e-117	385.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1XDZV@135618|Methylococcales	135618|Methylococcales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CH3_k127_5035721_3	743836.AYNA01000076_gene2874	5.539e-06	52.0	COG2114@1|root,COG2199@1|root,COG2114@2|Bacteria,COG3706@2|Bacteria,1QU6G@1224|Proteobacteria,2TW1I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HisKA,Response_reg
CH3_k127_5035721_2	765420.OSCT_1937	6.165e-51	183.0	COG0745@1|root,COG0745@2|Bacteria,2G9Q2@200795|Chloroflexi,377GJ@32061|Chloroflexia	32061|Chloroflexia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CH3_k127_5035721_0	686340.Metal_3572	7.203e-232	735.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T4BK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CH3_k127_5035721_1	686340.Metal_3571	3.697e-65	227.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg
CH3_k127_5036697_3	1116472.MGMO_53c00940	2.635e-08	55.0	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,1XFAU@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
CH3_k127_5036697_0	857087.Metme_3772	2.254e-271	841.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,1XEWM@135618|Methylococcales	135618|Methylococcales	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
CH3_k127_5036697_2	857087.Metme_3773	4.312e-232	729.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XEU4@135618|Methylococcales	135618|Methylococcales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
CH3_k127_5036697_1	697282.Mettu_4285	5.559e-267	827.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,1XES5@135618|Methylococcales	135618|Methylococcales	H	HI0933-like protein	-	-	1.14.99.44	ko:K10210	ko00906,map00906	-	R07654,R09671,R09727,R09728	RC00254,RC02089,RC02626,RC02638	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
CH3_k127_5043280_1	697282.Mettu_0987	1.211e-104	347.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1XDJR@135618|Methylococcales	135618|Methylococcales	EGP	Nucleoside H+ symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
CH3_k127_5043280_0	686340.Metal_0976	8.078e-203	634.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1XDME@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
CH3_k127_5043280_2	697282.Mettu_0985	5.51e-39	146.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1XE1V@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
CH3_k127_5072887_2	697282.Mettu_1061	3.639e-71	243.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales	135618|Methylococcales	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
CH3_k127_5072887_0	697282.Mettu_3267	1.102e-290	898.0	COG0119@1|root,COG0119@2|Bacteria,1R7YB@1224|Proteobacteria,1RQB8@1236|Gammaproteobacteria,1XEJD@135618|Methylococcales	135618|Methylococcales	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CH3_k127_5072887_1	1116472.MGMO_9c00300	6.237e-254	797.0	COG2202@1|root,COG2208@1|root,COG5000@1|root,COG2202@2|Bacteria,COG2208@2|Bacteria,COG5000@2|Bacteria,1RGZF@1224|Proteobacteria,1S6GG@1236|Gammaproteobacteria,1XDM4@135618|Methylococcales	135618|Methylococcales	KT	PFAM Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9,SpoIIE
CH3_k127_5072887_4	502025.Hoch_4114	3.27e-22	99.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions	1224|Proteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,PP2C_2,Pkinase,TPR_12
CH3_k127_5072887_3	246197.MXAN_2037	1.209e-32	137.0	COG4104@1|root,COG4104@2|Bacteria,1QX8X@1224|Proteobacteria	1224|Proteobacteria	S	PAAR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5099501_2	573370.DMR_16270	6.695e-94	319.0	COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,42PXT@68525|delta/epsilon subdivisions,2WR2Y@28221|Deltaproteobacteria,2MAJD@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
CH3_k127_5099501_3	697282.Mettu_4385	1.798e-71	255.0	2A046@1|root,30N6R@2|Bacteria,1QB85@1224|Proteobacteria,1THXY@1236|Gammaproteobacteria,1XG0K@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5099501_1	243233.MCA2711	5.912e-213	675.0	COG1141@1|root,COG2124@1|root,COG1141@2|Bacteria,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,1RY69@1236|Gammaproteobacteria,1XFKB@135618|Methylococcales	135618|Methylococcales	C	Cytochrome P450	-	-	1.14.13.70	ko:K05917	ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130	M00101	R05640,R05731	RC01442	ko00000,ko00001,ko00002,ko00199,ko01000	-	-	-	p450
CH3_k127_5099501_0	243233.MCA1013	1.38e-261	825.0	COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1XDIY@135618|Methylococcales	1236|Gammaproteobacteria	S	TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CH3_k127_5122681_0	857087.Metme_0581	1.065e-218	687.0	COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,1T2RV@1236|Gammaproteobacteria,1XENI@135618|Methylococcales	135618|Methylococcales	S	Pfam Transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5122681_1	686340.Metal_3214	1.04e-158	510.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1XEF2@135618|Methylococcales	135618|Methylococcales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
CH3_k127_5148436_0	686340.Metal_1397	4.609e-74	252.0	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1XENM@135618|Methylococcales	135618|Methylococcales	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxH	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos
CH3_k127_5148436_1	1116472.MGMO_5c00030	4.415e-62	219.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1XF53@135618|Methylococcales	135618|Methylococcales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CH3_k127_5148436_2	1116472.MGMO_5c00020	4.311e-58	205.0	COG3439@1|root,COG3439@2|Bacteria,1NFEI@1224|Proteobacteria,1SCZP@1236|Gammaproteobacteria,1XFC2@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
CH3_k127_5148436_3	686340.Metal_2464	1.248e-38	151.0	2C7YM@1|root,32RK3@2|Bacteria,1N2IQ@1224|Proteobacteria,1SDXB@1236|Gammaproteobacteria,1XFBF@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_526941_9	697282.Mettu_3968	4.744e-60	211.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,1XFME@135618|Methylococcales	135618|Methylococcales	C	Cytochrome b/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
CH3_k127_526941_2	713586.KB900536_gene1619	3.003e-119	398.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales	135613|Chromatiales	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
CH3_k127_526941_5	686340.Metal_3554	1.552e-79	272.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1XF2H@135618|Methylococcales	135618|Methylococcales	V	PFAM N-acetylmuramoyl-L-alanine amidase	ampD	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
CH3_k127_526941_3	857087.Metme_4340	4.245e-111	365.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1XE1T@135618|Methylococcales	135618|Methylococcales	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
CH3_k127_526941_7	697282.Mettu_1548	1.778e-62	219.0	COG1853@1|root,COG1853@2|Bacteria,1QSGJ@1224|Proteobacteria,1S5ST@1236|Gammaproteobacteria,1XF9G@135618|Methylococcales	135618|Methylococcales	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CH3_k127_526941_6	857087.Metme_1141	1.614e-73	250.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1XEYU@135618|Methylococcales	135618|Methylococcales	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
CH3_k127_526941_1	697282.Mettu_3557	6.969e-215	672.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1XDVM@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
CH3_k127_526941_8	697282.Mettu_3560	2.165e-60	209.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1XF7Y@135618|Methylococcales	135618|Methylococcales	C	Iron-sulfur cluster insertion protein ErpA	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
CH3_k127_526941_0	857087.Metme_2699	5.809e-272	841.0	COG2807@1|root,COG2807@2|Bacteria,1QU0F@1224|Proteobacteria,1T1JZ@1236|Gammaproteobacteria,1XETP@135618|Methylococcales	135618|Methylococcales	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CH3_k127_526941_10	1283300.ATXB01000001_gene2234	6.255e-07	53.0	COG2807@1|root,COG2807@2|Bacteria,1QU0F@1224|Proteobacteria,1T1JZ@1236|Gammaproteobacteria,1XETP@135618|Methylococcales	135618|Methylococcales	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CH3_k127_526941_4	663610.JQKO01000009_gene429	1.98e-86	297.0	COG1652@1|root,COG2608@1|root,COG2836@1|root,COG4633@1|root,COG1652@2|Bacteria,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1PJEP@1224|Proteobacteria,2U3C2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2,HMA,LysM
CH3_k127_5320889_2	1250278.JQNQ01000001_gene2919	2.382e-27	111.0	COG1403@1|root,COG1403@2|Bacteria,4NZB8@976|Bacteroidetes,1I762@117743|Flavobacteriia	976|Bacteroidetes	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
CH3_k127_5320889_0	1116472.MGMO_29c00180	1.768e-156	502.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1XDK1@135618|Methylococcales	135618|Methylococcales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CH3_k127_5320889_1	1232683.ADIMK_0388	3.289e-81	280.0	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,46511@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,1.3.1.43,2.5.1.19	ko:K00210,ko:K00220,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025,M00040	R00732,R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
CH3_k127_5320889_3	857087.Metme_1881	5.825e-11	62.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1XE66@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
CH3_k127_5344831_0	1116472.MGMO_144c00240	1.795e-304	935.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1XDZ8@135618|Methylococcales	135618|Methylococcales	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	-	-	-	-	-	-	-	-	-	-	PQQ
CH3_k127_5344831_5	686340.Metal_1194	2.601e-41	153.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,1XFJ2@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
CH3_k127_5344831_7	243233.MCA2340	1.835e-24	102.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1XFR0@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
CH3_k127_5344831_2	686340.Metal_1692	2.59e-165	524.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1XEJA@135618|Methylococcales	135618|Methylococcales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
CH3_k127_5344831_4	697282.Mettu_0043	1.594e-69	238.0	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,1XFEJ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	-	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
CH3_k127_5344831_1	686340.Metal_0004	1.535e-226	707.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1XDZC@135618|Methylococcales	135618|Methylococcales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
CH3_k127_5344831_8	686340.Metal_0003	6.933e-16	77.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,1XFUB@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
CH3_k127_5344831_6	686340.Metal_0002	8.021e-40	151.0	COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,1XFKR@135618|Methylococcales	135618|Methylococcales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
CH3_k127_5344831_3	697282.Mettu_1950	5.895e-141	460.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1XDR6@135618|Methylococcales	135618|Methylococcales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
CH3_k127_53865_1	686340.Metal_1169	2.725e-54	192.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDWS@135618|Methylococcales	135618|Methylococcales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CH3_k127_53865_2	436308.Nmar_1148	1.24e-42	166.0	COG1651@1|root,arCOG02868@2157|Archaea	2157|Archaea	O	COG1651 Protein-disulfide isomerase	-	-	-	ko:K21990	-	-	-	-	ko00000	1.A.16.4	-	-	Form_Nir_trans,Thioredoxin_4
CH3_k127_53865_0	697282.Mettu_4324	6.83e-238	739.0	COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,1XEFP@135618|Methylococcales	135618|Methylococcales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CH3_k127_53865_3	857087.Metme_3953	2.911e-28	114.0	COG0607@1|root,30JW6@2|Bacteria,1PGPU@1224|Proteobacteria,1RUXS@1236|Gammaproteobacteria,1XGR5@135618|Methylococcales	135618|Methylococcales	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CH3_k127_5420119_0	857087.Metme_3278	1.605e-151	482.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RQ2G@1236|Gammaproteobacteria,1XDIS@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CH3_k127_5420119_1	857087.Metme_2003	9.88e-137	441.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	KorB,ParBc
CH3_k127_5420119_2	1259795.ARJK01000002_gene95	1.485e-17	89.0	COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,249RK@186801|Clostridia,42F92@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the carbohydrate kinase PfkB family. LacC subfamily	pfkB	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CH3_k127_5461730_2	857087.Metme_2628	9.72e-134	430.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1XDSZ@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
CH3_k127_5461730_3	857087.Metme_2627	3.335e-123	396.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,1XE07@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CH3_k127_5461730_4	857087.Metme_2626	3.273e-113	367.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,1XE4G@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0055114	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CH3_k127_5461730_0	697282.Mettu_4218	2.732e-231	720.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1XECA@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
CH3_k127_5461730_6	1116472.MGMO_21c00170	3.71e-17	83.0	COG2991@1|root,COG2991@2|Bacteria,1NI0R@1224|Proteobacteria,1SGJF@1236|Gammaproteobacteria,1XFQH@135618|Methylococcales	135618|Methylococcales	S	(Na+)-NQR maturation NqrM	-	-	-	ko:K05952	-	-	-	-	ko00000	-	-	-	NqrM
CH3_k127_5461730_5	857087.Metme_2783	5.676e-49	179.0	COG0517@1|root,COG0517@2|Bacteria,1QTZR@1224|Proteobacteria,1S7SY@1236|Gammaproteobacteria,1XFFM@135618|Methylococcales	135618|Methylococcales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CH3_k127_5461730_1	697282.Mettu_4215	4.888e-168	536.0	COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1XEUD@135618|Methylococcales	135618|Methylococcales	L	Exonuclease C-terminal	sbcB	-	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
CH3_k127_5467308_3	686340.Metal_3670	1.504e-157	506.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1XEIS@135618|Methylococcales	135618|Methylococcales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	ubiH	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
CH3_k127_5467308_1	1116472.MGMO_85c00090	2.175e-230	718.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1XE0U@135618|Methylococcales	135618|Methylococcales	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
CH3_k127_5467308_5	857087.Metme_0778	1.864e-47	176.0	COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1XFDI@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0149 family	-	-	-	ko:K09895	-	-	-	-	ko00000	-	-	-	UPF0149
CH3_k127_5467308_7	857087.Metme_0777	1.431e-17	85.0	2AP81@1|root,31E9W@2|Bacteria,1QH87@1224|Proteobacteria,1SX59@1236|Gammaproteobacteria,1XFQ7@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	ko:K09892	-	-	-	-	ko00000,ko03036	-	-	-	-
CH3_k127_5467308_6	697282.Mettu_1804	4.098e-25	109.0	COG3027@1|root,COG3027@2|Bacteria,1PDNP@1224|Proteobacteria,1THU0@1236|Gammaproteobacteria,1XFQ1@135618|Methylococcales	135618|Methylococcales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
CH3_k127_5467308_4	697282.Mettu_2812	4.008e-142	459.0	COG5309@1|root,COG5309@2|Bacteria,1QHPS@1224|Proteobacteria,1TFDF@1236|Gammaproteobacteria,1XES1@135618|Methylococcales	135618|Methylococcales	G	glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5467308_0	697282.Mettu_3873	0.0	1311.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1XEU2@135618|Methylococcales	135618|Methylococcales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CH3_k127_5467308_2	697282.Mettu_3874	3.859e-229	714.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1XDTP@135618|Methylococcales	135618|Methylococcales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CH3_k127_5482616_2	686340.Metal_1169	2.128e-33	131.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDWS@135618|Methylococcales	135618|Methylococcales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CH3_k127_5482616_1	697282.Mettu_4327	1.214e-98	334.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,1SYRU@1236|Gammaproteobacteria,1XDWY@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CH3_k127_5482616_0	686340.Metal_1171	5.369e-158	509.0	COG1538@1|root,COG1538@2|Bacteria,1R8XP@1224|Proteobacteria,1SZE3@1236|Gammaproteobacteria,1XEJN@135618|Methylococcales	135618|Methylococcales	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CH3_k127_5490850_1	765911.Thivi_2799	4.998e-82	286.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1WWK2@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CH3_k127_5490850_0	1122599.AUGR01000005_gene1832	3.751e-135	441.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH4Q@135619|Oceanospirillales	135619|Oceanospirillales	V	efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CH3_k127_5500003_0	697282.Mettu_1845	8.935e-169	533.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1XDQG@135618|Methylococcales	135618|Methylococcales	P	Phosphate transport system permease protein	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
CH3_k127_5500003_1	1116472.MGMO_84c00010	3.981e-135	434.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1XDTC@135618|Methylococcales	135618|Methylococcales	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
CH3_k127_5500003_2	686340.Metal_3270	4.806e-93	312.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1XENE@135618|Methylococcales	135618|Methylococcales	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CH3_k127_5500003_6	1121875.KB907553_gene20	0.000215	44.0	COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
CH3_k127_5500003_5	690850.Desaf_0975	7.812e-21	94.0	2ADPE@1|root,313EG@2|Bacteria,1NEWZ@1224|Proteobacteria,42V0P@68525|delta/epsilon subdivisions,2WSFD@28221|Deltaproteobacteria,2MFC5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
CH3_k127_5500003_4	690850.Desaf_0974	1.893e-39	150.0	2E8QN@1|root,3331M@2|Bacteria,1ND4I@1224|Proteobacteria,430TR@68525|delta/epsilon subdivisions,2WVZ7@28221|Deltaproteobacteria,2MF52@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5500003_3	1116472.MGMO_83c00220	3.565e-82	277.0	COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria	1224|Proteobacteria	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
CH3_k127_5513626_7	85643.Tmz1t_2088	5.514e-09	59.0	2EHPP@1|root,33BFG@2|Bacteria,1NNJM@1224|Proteobacteria,2VYUZ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5513626_6	1454004.AW11_03128	1.04e-12	70.0	2EHPP@1|root,33BFG@2|Bacteria,1NNJM@1224|Proteobacteria,2VYUZ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5513626_0	85643.Tmz1t_2089	6.079e-114	372.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VKCG@28216|Betaproteobacteria,2M01N@206389|Rhodocyclales	28216|Betaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CH3_k127_5513626_2	1454004.AW11_03130	2.208e-95	318.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VHIG@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
CH3_k127_5513626_5	388051.AUFE01000192_gene3941	3.435e-24	102.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VHIG@28216|Betaproteobacteria,1KH00@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
CH3_k127_5513626_3	237609.PSAKL28_30590	7.101e-92	313.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,1S4Y0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
CH3_k127_5513626_4	1288826.MSNKSG1_03520	2.741e-91	310.0	COG4974@1|root,COG4974@2|Bacteria,1QVIY@1224|Proteobacteria,1T3E7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
CH3_k127_5513626_1	1288826.MSNKSG1_03515	3.361e-110	364.0	COG4974@1|root,COG4974@2|Bacteria,1R72R@1224|Proteobacteria,1S8CW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
CH3_k127_5524611_0	335543.Sfum_2957	2.732e-240	750.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MQBA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CH3_k127_5524611_3	857087.Metme_0663	1.145e-31	124.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XFQ2@135618|Methylococcales	135618|Methylococcales	K	SMART Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CH3_k127_5524611_2	686340.Metal_3950	1.272e-72	250.0	COG0500@1|root,COG2226@2|Bacteria,1MYPU@1224|Proteobacteria,1SZ13@1236|Gammaproteobacteria,1XE4M@135618|Methylococcales	135618|Methylococcales	H	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CH3_k127_5524611_1	686340.Metal_3357	2.665e-83	284.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1XEWR@135618|Methylococcales	135618|Methylococcales	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
CH3_k127_5524611_4	686340.Metal_3054	3.484e-12	67.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales	135618|Methylococcales	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel,MscS_TM,MscS_porin
CH3_k127_5528757_0	857087.Metme_4105	3.168e-313	976.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1XDTT@135618|Methylococcales	135618|Methylococcales	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
CH3_k127_5528757_7	264732.Moth_0514	6.352e-11	68.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,42GI5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
CH3_k127_5528757_3	240016.ABIZ01000001_gene4052	4.239e-147	475.0	COG0076@1|root,COG0076@2|Bacteria	2|Bacteria	E	glutamate decarboxylase activity	hdc	-	4.1.1.22	ko:K01590	ko00340,ko01100,ko01110,map00340,map01100,map01110	-	R01167	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
CH3_k127_5528757_8	1117647.M5M_05355	2.666e-08	55.0	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,1J6PT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the ArsC family	yffB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
CH3_k127_5528757_1	697282.Mettu_0479	1.31e-184	583.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1XEMH@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
CH3_k127_5528757_2	697282.Mettu_3184	2.137e-160	522.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1XEGJ@135618|Methylococcales	135618|Methylococcales	M	membrane-bound lytic murein transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
CH3_k127_5528757_4	697282.Mettu_3185	7.578e-71	246.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1XEM0@135618|Methylococcales	135618|Methylococcales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CH3_k127_5528757_5	686340.Metal_3825	1.513e-66	230.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1XF5B@135618|Methylococcales	135618|Methylococcales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
CH3_k127_5528757_6	756272.Plabr_3346	3.132e-45	166.0	COG0733@1|root,COG0733@2|Bacteria,2J29X@203682|Planctomycetes	203682|Planctomycetes	S	Sodium:neurotransmitter symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SNF
CH3_k127_5544462_0	1116472.MGMO_55c00020	8.434e-320	983.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,1RME6@1236|Gammaproteobacteria,1XDVW@135618|Methylococcales	135618|Methylococcales	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
CH3_k127_5544462_1	671143.DAMO_2045	6.409e-46	167.0	COG0210@1|root,COG2026@1|root,COG0210@2|Bacteria,COG2026@2|Bacteria,2NS08@2323|unclassified Bacteria	2|Bacteria	L	UvrD-like helicase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C
CH3_k127_5552483_0	686340.Metal_2695	0.0	999.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,1XEX0@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM Nitrate transport ATP-binding	-	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
CH3_k127_5552483_2	697282.Mettu_1166	7.52e-179	564.0	COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,1RPP1@1236|Gammaproteobacteria,1XE8H@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15577	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	BPD_transp_1
CH3_k127_5552483_1	1397527.Q670_10440	7.854e-237	738.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,1XIGG@135619|Oceanospirillales	135619|Oceanospirillales	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	nrtC	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
CH3_k127_5572974_1	697282.Mettu_1816	1.054e-80	275.0	COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,1T1Q4@1236|Gammaproteobacteria,1XE42@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA
CH3_k127_5572974_0	287.DR97_1851	2.642e-168	540.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1YDVE@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Bacterial regulatory protein, Fis family	pilR	-	-	ko:K02481,ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
CH3_k127_5572974_2	686340.Metal_3668	7.905e-25	109.0	2FGP6@1|root,348IS@2|Bacteria,1P1GW@1224|Proteobacteria,1SREF@1236|Gammaproteobacteria,1XFP1@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5599092_24	686340.Metal_1190	2.377e-40	151.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1XEKU@135618|Methylococcales	135618|Methylococcales	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
CH3_k127_5599092_3	686340.Metal_1191	8.665e-201	635.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XE18@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CH3_k127_5599092_4	857087.Metme_1267	6.344e-181	569.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1XE9Q@135618|Methylococcales	135618|Methylococcales	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
CH3_k127_5599092_2	857087.Metme_1268	2.327e-203	639.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1XEJF@135618|Methylococcales	135618|Methylococcales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CH3_k127_5599092_1	697282.Mettu_2189	1.149e-234	730.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1XE5W@135618|Methylococcales	135618|Methylococcales	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CH3_k127_5599092_28	1116472.MGMO_52c00120	9.776e-13	70.0	2AY0P@1|root,31Q28@2|Bacteria,1QIYS@1224|Proteobacteria,1TGVF@1236|Gammaproteobacteria,1XGT2@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5599092_26	686340.Metal_3252	8.493e-33	133.0	COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria,1XF8X@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0307 family	-	-	-	ko:K09889	-	-	-	-	ko00000,ko03009	-	-	-	DUF615
CH3_k127_5599092_23	697282.Mettu_0818	7.847e-45	170.0	COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1XFK3@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
CH3_k127_5599092_27	203122.Sde_1626	9.891e-23	98.0	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,468BN@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
CH3_k127_5599092_7	697282.Mettu_0820	2.346e-158	505.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1XDYY@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
CH3_k127_5599092_8	697282.Mettu_0821	4.991e-157	499.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1XENR@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CH3_k127_5599092_12	697282.Mettu_0822	2.896e-143	462.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1XDSP@135618|Methylococcales	135618|Methylococcales	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CH3_k127_5599092_15	1116472.MGMO_146c00190	6.141e-122	394.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1XDSR@135618|Methylococcales	135618|Methylococcales	IQ	3-oxoacyl-(Acyl-carrier-protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CH3_k127_5599092_25	686340.Metal_1618	7.517e-35	134.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,1XFN1@135618|Methylococcales	135618|Methylococcales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CH3_k127_5599092_0	686340.Metal_1617	3.743e-237	736.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XE1J@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CH3_k127_5599092_17	697282.Mettu_0826	3.05e-99	331.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1XEKT@135618|Methylococcales	135618|Methylococcales	EH	PFAM Aminotransferase, class IV	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
CH3_k127_5599092_13	697282.Mettu_0827	1.211e-127	417.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1XDXF@135618|Methylococcales	135618|Methylococcales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
CH3_k127_5599092_19	697282.Mettu_0828	4.874e-82	277.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1XEZX@135618|Methylococcales	135618|Methylococcales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CH3_k127_5599092_18	686340.Metal_1613	7.347e-96	324.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1XDVJ@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase III, delta'	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
CH3_k127_5599092_21	857087.Metme_3485	8.006e-55	196.0	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1XF9T@135618|Methylococcales	135618|Methylococcales	NU	PFAM Type IV pilus assembly PilZ	pilZ	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
CH3_k127_5599092_14	697282.Mettu_0831	1.699e-124	403.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1XEJI@135618|Methylococcales	135618|Methylococcales	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CH3_k127_5599092_16	686340.Metal_0726	7.641e-122	394.0	COG0412@1|root,COG0412@2|Bacteria,1NKIB@1224|Proteobacteria,1S1VI@1236|Gammaproteobacteria,1XESX@135618|Methylococcales	135618|Methylococcales	Q	PFAM Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
CH3_k127_5599092_10	1278073.MYSTI_00116	1.614e-150	490.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42MPR@68525|delta/epsilon subdivisions,2WNM3@28221|Deltaproteobacteria,2YZ2D@29|Myxococcales	28221|Deltaproteobacteria	Q	Multicopper oxidase	-	-	-	ko:K04753	-	-	-	-	ko00000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
CH3_k127_5599092_6	686340.Metal_0530	2.061e-170	539.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1XE2Q@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CH3_k127_5599092_22	1116472.MGMO_94c00570	3.561e-54	197.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,1XF19@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
CH3_k127_5599092_20	598467.BrE312_3678	5.528e-66	228.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,1S3QM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0178 family	yaiI	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
CH3_k127_5599092_11	697282.Mettu_2955	4.581e-144	464.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,1RZ9I@1236|Gammaproteobacteria,1XDNR@135618|Methylococcales	135618|Methylococcales	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CH3_k127_5599092_9	686340.Metal_1128	2.498e-155	494.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1SYTB@1236|Gammaproteobacteria,1XDPN@135618|Methylococcales	135618|Methylococcales	S	PFAM Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CH3_k127_5599092_5	697282.Mettu_0462	5.579e-180	569.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,1XDT2@135618|Methylococcales	135618|Methylococcales	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CH3_k127_5608867_4	697282.Mettu_2039	4.329e-103	337.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1XEH9@135618|Methylococcales	135618|Methylococcales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
CH3_k127_5608867_8	697282.Mettu_4344	3.229e-05	52.0	2AW8R@1|root,31N40@2|Bacteria,1QJVG@1224|Proteobacteria,1THX3@1236|Gammaproteobacteria,1XFXI@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
CH3_k127_5608867_2	857087.Metme_4126	5.238e-141	452.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1XDMX@135618|Methylococcales	135618|Methylococcales	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
CH3_k127_5608867_0	697282.Mettu_3676	6.571e-192	610.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1XEP5@135618|Methylococcales	135618|Methylococcales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CH3_k127_5608867_1	697282.Mettu_3675	5.887e-173	552.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1XEB0@135618|Methylococcales	135618|Methylococcales	S	PFAM Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
CH3_k127_5608867_6	1484158.PSNIH1_06895	1.934e-56	203.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,3VZ00@53335|Pantoea	1236|Gammaproteobacteria	L	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
CH3_k127_5608867_7	697282.Mettu_3057	6.074e-12	68.0	2AVBS@1|root,31M32@2|Bacteria,1QIYB@1224|Proteobacteria,1TGV0@1236|Gammaproteobacteria,1XGRT@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
CH3_k127_5608867_5	697282.Mettu_3058	1.051e-65	228.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1XFEK@135618|Methylococcales	135618|Methylococcales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CH3_k127_5608867_3	686340.Metal_3574	5.591e-123	406.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RX1K@1236|Gammaproteobacteria,1XGJU@135618|Methylococcales	135618|Methylococcales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CH3_k127_5618485_3	1116472.MGMO_27c00290	1.548e-61	215.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,1XDYA@135618|Methylococcales	135618|Methylococcales	Q	Flavin containing amine oxidoreductase	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
CH3_k127_5618485_2	1283300.ATXB01000002_gene3154	3.217e-78	263.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,1S45S@1236|Gammaproteobacteria,1XF2W@135618|Methylococcales	135618|Methylococcales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
CH3_k127_5618485_4	1116472.MGMO_53c00050	1.995e-18	86.0	COG2906@1|root,COG2906@2|Bacteria,1PQEY@1224|Proteobacteria,1TG7E@1236|Gammaproteobacteria,1XFV2@135618|Methylococcales	135618|Methylococcales	P	PFAM BFD-like 2Fe-2S -binding	-	-	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
CH3_k127_5618485_0	697282.Mettu_1412	4.271e-241	754.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XE9U@135618|Methylococcales	135618|Methylococcales	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CH3_k127_5618485_1	1116472.MGMO_26c00260	4.955e-93	308.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,1RMH9@1236|Gammaproteobacteria,1XDQZ@135618|Methylococcales	135618|Methylococcales	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
CH3_k127_5618485_5	857087.Metme_0728	2.008e-10	61.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,1XEQ6@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	-	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
CH3_k127_5690066_3	1121935.AQXX01000110_gene5464	2.041e-08	57.0	COG2373@1|root,COG3755@1|root,COG2373@2|Bacteria,COG3755@2|Bacteria,1MV7J@1224|Proteobacteria,1RNRY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,LprI,MG1
CH3_k127_5690066_1	686340.Metal_1706	1.8e-137	447.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,1RZ65@1236|Gammaproteobacteria,1XGI5@135618|Methylococcales	135618|Methylococcales	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
CH3_k127_5690066_0	686340.Metal_1707	8.745e-247	787.0	COG0577@1|root,COG0577@2|Bacteria,1PJZX@1224|Proteobacteria,1RU56@1236|Gammaproteobacteria,1XDTW@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CH3_k127_5690066_2	472759.Nhal_1409	5.208e-33	128.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,1S2XY@1236|Gammaproteobacteria,1WYES@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_5753232_1	857087.Metme_3257	7.779e-126	409.0	COG0583@1|root,COG0583@2|Bacteria,1MVHT@1224|Proteobacteria,1RN7G@1236|Gammaproteobacteria,1XEZC@135618|Methylococcales	135618|Methylococcales	K	LysR substrate binding domain	-	-	-	ko:K03717	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
CH3_k127_5753232_2	1288494.EBAPG3_10800	2.107e-107	357.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,371XA@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	rimN	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
CH3_k127_5753232_4	1162668.LFE_1832	1.163e-12	68.0	2DBB9@1|root,2Z86U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5753232_3	380394.Lferr_1367	4.952e-14	75.0	2DBB9@1|root,2Z86U@2|Bacteria,1RC32@1224|Proteobacteria,1S6WK@1236|Gammaproteobacteria,2NDEN@225057|Acidithiobacillales	225057|Acidithiobacillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5753232_0	686340.Metal_1802	4.366e-163	514.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,1RNAD@1236|Gammaproteobacteria,1XECQ@135618|Methylococcales	135618|Methylococcales	H	Sulfate adenylyltransferase subunit 2	cysD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004779,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
CH3_k127_5755773_0	697282.Mettu_3243	3.094e-166	530.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,1RYUT@1236|Gammaproteobacteria,1XEKZ@135618|Methylococcales	135618|Methylococcales	S	PFAM Cytochrome d1	-	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
CH3_k127_5755773_3	933262.AXAM01000003_gene2814	7.018e-06	51.0	2E7P1@1|root,3324M@2|Bacteria,1Q68Q@1224|Proteobacteria,432MQ@68525|delta/epsilon subdivisions,2WYDU@28221|Deltaproteobacteria,2MPDC@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5755773_2	891968.Anamo_0542	1.037e-12	70.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5755773_1	686340.Metal_2267	1.516e-23	101.0	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,1SFGZ@1236|Gammaproteobacteria,1XFNP@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
CH3_k127_5819017_0	1116472.MGMO_176c00080	1.016e-180	584.0	COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,1RYF5@1236|Gammaproteobacteria,1XG93@135618|Methylococcales	135618|Methylococcales	G	HpcH/HpaI aldolase/citrate lyase family	-	-	-	-	-	-	-	-	-	-	-	-	PK
CH3_k127_5819017_1	1244869.H261_01836	5.088e-34	134.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2JQH4@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
CH3_k127_5894375_0	288000.BBta_0599	0.0	1048.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
CH3_k127_5894375_3	247490.KSU1_C1440	6.21e-37	149.0	2DSS0@1|root,33H81@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
CH3_k127_5894375_1	909663.KI867149_gene3370	1.946e-152	503.0	COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,42Q3C@68525|delta/epsilon subdivisions,2WMAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
CH3_k127_5894375_2	1249627.D779_3579	5.772e-52	185.0	COG1974@1|root,COG1974@2|Bacteria,1MZFA@1224|Proteobacteria,1S5X5@1236|Gammaproteobacteria,1WYGY@135613|Chromatiales	135613|Chromatiales	KT	Belongs to the peptidase S24 family	-	-	-	ko:K03503	-	-	-	-	ko00000,ko01000,ko01002,ko03400	-	-	-	Peptidase_S24
CH3_k127_589518_2	1116472.MGMO_128c00090	8.047e-284	875.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1XDM1@135618|Methylococcales	135618|Methylococcales	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
CH3_k127_589518_4	686340.Metal_3161	7.49e-47	170.0	COG2146@1|root,COG2146@2|Bacteria,1MZBY@1224|Proteobacteria,1S9F1@1236|Gammaproteobacteria,1XFAJ@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM nitrite reductase NAD(P)H	-	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske_2
CH3_k127_589518_3	697282.Mettu_1149	4.309e-134	433.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,1RPWM@1236|Gammaproteobacteria,1XEX6@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM phenazine biosynthesis	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
CH3_k127_589518_0	1116472.MGMO_128c00120	0.0	1247.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1XEE6@135618|Methylococcales	135618|Methylococcales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
CH3_k127_589518_1	1116472.MGMO_128c00130	3.357e-309	957.0	COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,1RNFG@1236|Gammaproteobacteria,1XFU7@135618|Methylococcales	135618|Methylococcales	C	4Fe-4S dicluster domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Form-deh_trans
CH3_k127_5958879_4	857087.Metme_0667	1.971e-85	285.0	COG2218@1|root,COG2218@2|Bacteria,1MUUQ@1224|Proteobacteria,1S19G@1236|Gammaproteobacteria,1XEVQ@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM formylmethanofuran dehydrogenase subunit C	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
CH3_k127_5958879_7	686340.Metal_0844	2.791e-17	82.0	2AW8E@1|root,31M5C@2|Bacteria,1QJ09@1224|Proteobacteria,1TGXH@1236|Gammaproteobacteria,1XGW0@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5958879_0	697282.Mettu_2949	2.751e-197	619.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1XFG4@135618|Methylococcales	135618|Methylococcales	P	Phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
CH3_k127_5958879_3	697282.Mettu_2950	4.866e-103	338.0	COG1392@1|root,COG1392@2|Bacteria,1PKQF@1224|Proteobacteria,1SMFE@1236|Gammaproteobacteria,1XG8F@135618|Methylococcales	135618|Methylococcales	P	Pit accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5958879_5	686340.Metal_1004	1.077e-47	176.0	2AUBI@1|root,31JZ8@2|Bacteria,1QIAB@1224|Proteobacteria,1TG4G@1236|Gammaproteobacteria,1XFK8@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5958879_6	857087.Metme_3552	2.333e-20	96.0	COG1198@1|root,COG1198@2|Bacteria	2|Bacteria	L	DNA replication, synthesis of RNA primer	yfgJ	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	zinc-ribbons_6
CH3_k127_5958879_2	686340.Metal_0248	7.899e-113	369.0	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,1S4UH@1236|Gammaproteobacteria,1XEJU@135618|Methylococcales	135618|Methylococcales	S	Mut7-C ubiquitin	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C,Ub-Mut7C
CH3_k127_5958879_1	1249627.D779_2430	6.442e-126	411.0	COG1449@1|root,COG1449@2|Bacteria,1R18I@1224|Proteobacteria,1SGAD@1236|Gammaproteobacteria,1X04T@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
CH3_k127_5995562_2	697282.Mettu_3799	2.874e-297	924.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1XE9Y@135618|Methylococcales	135618|Methylococcales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
CH3_k127_5995562_4	686340.Metal_0699	5.768e-179	567.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1XDK4@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
CH3_k127_5995562_8	686340.Metal_0698	2.149e-54	192.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1XF6T@135618|Methylococcales	135618|Methylococcales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
CH3_k127_5995562_10	1116472.MGMO_41c00390	6.391e-28	116.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1XFG5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
CH3_k127_5995562_6	857087.Metme_1718	4.562e-81	272.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1XF2T@135618|Methylococcales	135618|Methylococcales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CH3_k127_5995562_0	697282.Mettu_3794	0.0	1105.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1XDMC@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
CH3_k127_5995562_1	857087.Metme_2971	0.0	1088.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1XED2@135618|Methylococcales	135618|Methylococcales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CH3_k127_5995562_3	857087.Metme_2593	8.57e-193	608.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1XE5B@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase, class I	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CH3_k127_5995562_9	1116472.MGMO_143c00040	3.351e-28	118.0	2B6TC@1|root,31ZSM@2|Bacteria,1QK6A@1224|Proteobacteria,1TI9J@1236|Gammaproteobacteria,1XGTJ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_5995562_5	697282.Mettu_2396	2.462e-120	392.0	2BVTQ@1|root,2Z7J9@2|Bacteria,1P01Z@1224|Proteobacteria,1RNNB@1236|Gammaproteobacteria,1XDPQ@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2797)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2797
CH3_k127_5995562_7	1254432.SCE1572_04135	4.191e-79	268.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42NZ1@68525|delta/epsilon subdivisions,2WNX5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
CH3_k127_6015210_3	1244083.CSUNSWCD_1051	1.175e-34	137.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,42RPP@68525|delta/epsilon subdivisions,2YP78@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	beta-lactamase activity	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
CH3_k127_6015210_2	697282.Mettu_0211	3.372e-42	157.0	2E7Z7@1|root,332DJ@2|Bacteria,1R3MR@1224|Proteobacteria,1SI8V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6015210_0	697282.Mettu_0224	0.0	1329.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEIG@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
CH3_k127_6015210_1	243233.MCA0851	4.997e-67	236.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RQ2G@1236|Gammaproteobacteria,1XDIS@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CH3_k127_60431_4	857087.Metme_0899	1.377e-26	111.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1XEY7@135618|Methylococcales	135618|Methylococcales	K	Ribosomal-protein-alanine acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
CH3_k127_60431_2	686340.Metal_2575	2.486e-87	297.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1XF2F@135618|Methylococcales	135618|Methylococcales	L	Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CH3_k127_60431_0	697282.Mettu_0033	2.211e-283	876.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1XDJV@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CH3_k127_60431_1	697282.Mettu_0034	3.978e-100	332.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,1XDVP@135618|Methylococcales	135618|Methylococcales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
CH3_k127_60431_3	697282.Mettu_3785	1.518e-45	167.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1XFCX@135618|Methylococcales	135618|Methylococcales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate	tsaC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
CH3_k127_6060135_0	391595.RLO149_c037000	2.087e-186	589.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CH3_k127_6107047_2	686340.Metal_3220	1.837e-87	291.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1XDNW@135618|Methylococcales	135618|Methylococcales	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CH3_k127_6107047_1	697282.Mettu_0029	1.115e-95	319.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1XEFC@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CH3_k127_6107047_0	686340.Metal_3222	6.238e-131	421.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1XDPS@135618|Methylococcales	135618|Methylococcales	E	TIGRFAM Serine O-acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
CH3_k127_6107047_4	697282.Mettu_0027	1.633e-72	248.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1XF1K@135618|Methylococcales	135618|Methylococcales	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
CH3_k127_6107047_3	697282.Mettu_0026	8.371e-87	293.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1XE3U@135618|Methylococcales	135618|Methylococcales	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CH3_k127_6151389_2	1196323.ALKF01000187_gene5786	3.054e-16	84.0	COG0500@1|root,COG2226@2|Bacteria,1TQEA@1239|Firmicutes,4HJYK@91061|Bacilli,26TVZ@186822|Paenibacillaceae	91061|Bacilli	Q	O-methyltransferase	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25,Ubie_methyltran
CH3_k127_6151389_1	1348657.M622_10900	3.975e-59	211.0	COG2020@1|root,COG2020@2|Bacteria,1PPQV@1224|Proteobacteria,2VR3S@28216|Betaproteobacteria,2KYVU@206389|Rhodocyclales	206389|Rhodocyclales	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	-
CH3_k127_6151389_0	686340.Metal_4030	2.934e-103	338.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria,1XFZU@135618|Methylococcales	135618|Methylococcales	L	Helix-hairpin-helix containing domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
CH3_k127_616667_0	697282.Mettu_3151	1.353e-315	984.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1XE55@135618|Methylococcales	135618|Methylococcales	K	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair	rapA	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Helicase_C,RapA_C,SNF2_N
CH3_k127_616667_2	697282.Mettu_3307	0.0002559	44.0	COG3637@1|root,COG3637@2|Bacteria,1R64D@1224|Proteobacteria,1S325@1236|Gammaproteobacteria,1XDN4@135618|Methylococcales	135618|Methylococcales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CH3_k127_616667_1	686340.Metal_1207	2.6e-18	85.0	COG3637@1|root,COG3637@2|Bacteria,1R64D@1224|Proteobacteria,1S325@1236|Gammaproteobacteria,1XDN4@135618|Methylococcales	135618|Methylococcales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CH3_k127_6178911_13	1116472.MGMO_143c00040	5.188e-07	54.0	2B6TC@1|root,31ZSM@2|Bacteria,1QK6A@1224|Proteobacteria,1TI9J@1236|Gammaproteobacteria,1XGTJ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6178911_10	153948.NAL212_0603	2.579e-20	91.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,2VSPX@28216|Betaproteobacteria,37475@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CH3_k127_6178911_6	1244869.H261_16780	3.515e-114	378.0	COG2899@1|root,COG2899@2|Bacteria,1NURT@1224|Proteobacteria,2TRRF@28211|Alphaproteobacteria,2JVZ8@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF475
CH3_k127_6178911_3	697282.Mettu_2441	1.324e-277	858.0	COG3596@1|root,COG3596@2|Bacteria,1P6GT@1224|Proteobacteria,1RZFQ@1236|Gammaproteobacteria,1XF0X@135618|Methylococcales	135618|Methylococcales	S	50S ribosome-binding GTPase	-	-	-	ko:K06946	-	-	-	-	ko00000	-	-	-	MMR_HSR1
CH3_k127_6178911_4	697282.Mettu_2440	2.304e-224	698.0	COG3596@1|root,COG3597@1|root,COG3596@2|Bacteria,COG3597@2|Bacteria,1MV2B@1224|Proteobacteria,1RQTJ@1236|Gammaproteobacteria,1XEWI@135618|Methylococcales	135618|Methylococcales	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
CH3_k127_6178911_1	697282.Mettu_1851	0.0	1126.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1XEGH@135618|Methylococcales	135618|Methylococcales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
CH3_k127_6178911_5	697282.Mettu_1850	5.736e-175	564.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria,1XDV6@135618|Methylococcales	135618|Methylococcales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
CH3_k127_6178911_8	1131553.JIBI01000024_gene96	2.499e-39	154.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,2VSHN@28216|Betaproteobacteria,373AQ@32003|Nitrosomonadales	28216|Betaproteobacteria	M	NlpC/P60 family	-	-	-	ko:K13695,ko:K19303	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
CH3_k127_6178911_9	768671.ThimaDRAFT_1059	6.004e-34	132.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales	135613|Chromatiales	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CH3_k127_6178911_0	857087.Metme_3258	0.0	1310.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_4025	PEPcase
CH3_k127_6178911_2	697282.Mettu_0748	0.0	1053.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XDZ2@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CH3_k127_6178911_12	686340.Metal_2525	2.566e-15	77.0	COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,1THV1@1236|Gammaproteobacteria,1XFT4@135618|Methylococcales	135618|Methylococcales	C	Heavy-metal-associated domain	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
CH3_k127_6178911_7	686340.Metal_2524	8.165e-85	285.0	COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1XEPZ@135618|Methylococcales	135618|Methylococcales	S	High frequency lysogenization protein HflD homolog	hflD	-	-	ko:K07153	-	-	-	-	ko00000	-	-	-	DUF489
CH3_k127_6178911_11	697282.Mettu_0744	8.065e-19	87.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1XDWI@135618|Methylococcales	135618|Methylococcales	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_6255872_11	580332.Slit_0753	1.116e-13	70.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,44V0D@713636|Nitrosomonadales	28216|Betaproteobacteria	J	elongation factor Tu	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CH3_k127_6255872_14	1410668.JNKC01000016_gene993	1.495e-06	49.0	2DES4@1|root,2ZP1M@2|Bacteria,1W3CF@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6255872_12	1535422.ND16A_2544	3.523e-10	60.0	2EG8N@1|root,33A0G@2|Bacteria,1NHU3@1224|Proteobacteria,1SGMX@1236|Gammaproteobacteria,2Q8EN@267889|Colwelliaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6255872_7	697282.Mettu_1349	1.897e-59	211.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1XF29@135618|Methylococcales	135618|Methylococcales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
CH3_k127_6255872_6	857087.Metme_3832	2.735e-76	260.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1XEUB@135618|Methylococcales	135618|Methylococcales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
CH3_k127_6255872_3	697282.Mettu_1351	3.803e-175	552.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1XDXQ@135618|Methylococcales	135618|Methylococcales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
CH3_k127_6255872_5	697282.Mettu_1352	2.242e-121	396.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1XE84@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CH3_k127_6255872_9	1116472.MGMO_88c00090	2.135e-39	153.0	COG3017@1|root,COG3017@2|Bacteria,1QJPB@1224|Proteobacteria,1THQ9@1236|Gammaproteobacteria,1XFAB@135618|Methylococcales	135618|Methylococcales	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	-	-	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
CH3_k127_6255872_4	697282.Mettu_1354	2.419e-171	555.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1XE13@135618|Methylococcales	135618|Methylococcales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
CH3_k127_6255872_1	697282.Mettu_1355	7.097e-207	650.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1XDJU@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
CH3_k127_6255872_2	697282.Mettu_1356	2.68e-189	595.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1XEPW@135618|Methylococcales	135618|Methylococcales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CH3_k127_6255872_0	1116472.MGMO_54c00100	1.88e-251	786.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,1S124@1236|Gammaproteobacteria,1XEG3@135618|Methylococcales	135618|Methylococcales	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
CH3_k127_6255872_10	1198232.CYCME_2314	1.126e-37	148.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,1SA2T@1236|Gammaproteobacteria,461HC@72273|Thiotrichales	72273|Thiotrichales	O	HupE / UreJ protein	-	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
CH3_k127_6255872_8	686340.Metal_0075	1.005e-40	154.0	COG5309@1|root,COG5309@2|Bacteria,1MWJJ@1224|Proteobacteria,1SJUJ@1236|Gammaproteobacteria,1XEPP@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolases family 17	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_17
CH3_k127_6342980_2	697282.Mettu_1512	1.27e-106	346.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria,1XDM0@135618|Methylococcales	135618|Methylococcales	C	PFAM NADH ubiquinone	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
CH3_k127_6342980_1	697282.Mettu_1513	2.413e-126	406.0	COG3383@1|root,COG3383@2|Bacteria,1MXTC@1224|Proteobacteria,1RZDX@1236|Gammaproteobacteria,1XER2@135618|Methylococcales	135618|Methylococcales	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
CH3_k127_6342980_0	697282.Mettu_1514	1.407e-278	863.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XE08@135618|Methylococcales	135618|Methylococcales	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	-	-	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S
CH3_k127_6412638_2	598467.BrE312_0922	4.601e-15	78.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	iSbBS512_1146.SbBS512_E0217	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
CH3_k127_6412638_0	697282.Mettu_3921	2.047e-316	988.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1XEFK@135618|Methylococcales	135618|Methylococcales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1
CH3_k127_6412638_1	1116472.MGMO_7c00040	2.32e-75	255.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1XDRP@135618|Methylococcales	135618|Methylococcales	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
CH3_k127_6416666_6	243233.MCA0043	1.187e-13	70.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,1S3FD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Ribose 5-phosphate isomerase	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008786,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046367,GO:0071704,GO:1901575	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c46440,ic_1306.c5096	LacAB_rpiB
CH3_k127_6416666_5	697282.Mettu_0838	1.769e-48	182.0	COG3115@1|root,COG3115@2|Bacteria,1PBVR@1224|Proteobacteria,1SWKQ@1236|Gammaproteobacteria,1XFD2@135618|Methylococcales	135618|Methylococcales	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	ko:K03528	-	-	-	-	ko00000,ko03036	-	-	-	ZipA_C
CH3_k127_6416666_0	697282.Mettu_0837	0.0	1258.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1XE2S@135618|Methylococcales	135618|Methylococcales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
CH3_k127_6416666_4	697282.Mettu_0836	1.41e-73	248.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1THNZ@1236|Gammaproteobacteria,1XF4B@135618|Methylococcales	135618|Methylococcales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
CH3_k127_6416666_2	1116472.MGMO_60c00390	2.241e-115	384.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1XE6R@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
CH3_k127_6416666_3	686340.Metal_0169	5.212e-112	367.0	COG3667@1|root,COG3667@2|Bacteria,1MXW6@1224|Proteobacteria,1RZEY@1236|Gammaproteobacteria,1XGPQ@135618|Methylococcales	135618|Methylococcales	P	Copper resistance protein B precursor (CopB)	-	-	-	-	-	-	-	-	-	-	-	-	CopB
CH3_k127_6416666_1	686340.Metal_0168	6.496e-227	715.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1XG3Q@135618|Methylococcales	135618|Methylococcales	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
CH3_k127_6455887_5	999141.GME_08289	1.06e-14	75.0	COG2329@1|root,COG2329@2|Bacteria,1MZKW@1224|Proteobacteria,1S9N8@1236|Gammaproteobacteria,1XKXM@135619|Oceanospirillales	135619|Oceanospirillales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CH3_k127_6455887_3	857087.Metme_4523	9.647e-44	167.0	2C3ZQ@1|root,32SCF@2|Bacteria,1N27R@1224|Proteobacteria,1S4HC@1236|Gammaproteobacteria,1XFHN@135618|Methylococcales	135618|Methylococcales	S	MEKHLA domain	-	-	-	-	-	-	-	-	-	-	-	-	MEKHLA
CH3_k127_6455887_4	1116472.MGMO_7c00130	2.872e-26	117.0	2EBDF@1|root,335E4@2|Bacteria,1NH7B@1224|Proteobacteria,1SHGY@1236|Gammaproteobacteria,1XFM2@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6455887_0	1116472.MGMO_7c00140	1.631e-108	357.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1XEBI@135618|Methylococcales	135618|Methylococcales	S	Belongs to the BI1 family	-	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
CH3_k127_6455887_2	857087.Metme_0480	1.253e-55	197.0	COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,1S98H@1236|Gammaproteobacteria,1XF5V@135618|Methylococcales	135618|Methylococcales	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
CH3_k127_6455887_1	697282.Mettu_0114	2.061e-85	290.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,1S9E4@1236|Gammaproteobacteria,1XEYC@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
CH3_k127_6534463_0	686340.Metal_2398	1.375e-219	687.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1XDZ5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
CH3_k127_6534463_1	697282.Mettu_2687	2.226e-28	120.0	COG2980@1|root,COG2980@2|Bacteria,1NGPX@1224|Proteobacteria,1SGKQ@1236|Gammaproteobacteria,1XFJ8@135618|Methylococcales	135618|Methylococcales	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
CH3_k127_6534470_0	697282.Mettu_2369	4.786e-183	578.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1XE6Q@135618|Methylococcales	135618|Methylococcales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
CH3_k127_6534470_1	243233.MCA1077	3.113e-170	540.0	COG2022@1|root,COG2104@1|root,COG2022@2|Bacteria,COG2104@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1XDXA@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
CH3_k127_6534470_2	697282.Mettu_2366	1.272e-57	204.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1XEBH@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
CH3_k127_6537045_0	697282.Mettu_0657	9.599e-77	258.0	COG3193@1|root,COG3193@2|Bacteria,1N1CR@1224|Proteobacteria,1SAFB@1236|Gammaproteobacteria,1XGXU@135618|Methylococcales	135618|Methylococcales	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
CH3_k127_6537045_1	153948.NAL212_0227	6.738e-58	209.0	COG0500@1|root,COG2226@2|Bacteria,1PE85@1224|Proteobacteria,2W92M@28216|Betaproteobacteria,373FB@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CH3_k127_6557378_1	857087.Metme_2623	7.766e-234	726.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales	135618|Methylococcales	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
CH3_k127_6557378_2	697282.Mettu_2643	2.73e-196	616.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1XEHE@135618|Methylococcales	135618|Methylococcales	G	fructose-bisphosphate aldolase, class II, yeast E. coli subtype	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
CH3_k127_6557378_3	857087.Metme_4076	3.1e-182	573.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,1RMS0@1236|Gammaproteobacteria,1XDSV@135618|Methylococcales	135618|Methylococcales	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CH3_k127_6557378_5	857087.Metme_0745	6.733e-12	74.0	2AW3M@1|root,31MYG@2|Bacteria,1QJQE@1224|Proteobacteria,1THRK@1236|Gammaproteobacteria,1XFG6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6557378_4	1116472.MGMO_45c00120	5.825e-40	157.0	2994J@1|root,2ZW81@2|Bacteria,1P4KK@1224|Proteobacteria,1ST9P@1236|Gammaproteobacteria,1XFJX@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6557378_0	857087.Metme_0743	0.0	1212.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XE7N@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CH3_k127_6646946_1	857087.Metme_2717	6.396e-75	253.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1XECM@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CH3_k127_6646946_0	395961.Cyan7425_5008	2.675e-280	870.0	COG0553@1|root,COG0553@2|Bacteria,1G2YQ@1117|Cyanobacteria,3KJJS@43988|Cyanothece	1117|Cyanobacteria	KL	COG0553 Superfamily II DNA RNA helicases, SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
CH3_k127_6680503_2	697282.Mettu_1826	2.064e-30	123.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XEER@135618|Methylococcales	135618|Methylococcales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
CH3_k127_6680503_0	857087.Metme_2907	9.871e-199	623.0	COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C8@1236|Gammaproteobacteria,1XH0M@135618|Methylococcales	135618|Methylococcales	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
CH3_k127_6680503_1	550540.Fbal_2786	1.347e-55	202.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	bepG	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CH3_k127_6731515_11	7244.FBpp0225305	0.0007442	43.0	COG5290@1|root,KOG1920@2759|Eukaryota,39DM9@33154|Opisthokonta,3BD96@33208|Metazoa,3CYHV@33213|Bilateria,41TKU@6656|Arthropoda,3SGJG@50557|Insecta,44YBW@7147|Diptera,45P8N@7214|Drosophilidae	33208|Metazoa	K	Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation	IKBKAP	GO:0000003,GO:0000049,GO:0000123,GO:0000166,GO:0001932,GO:0002097,GO:0002098,GO:0002119,GO:0002164,GO:0002376,GO:0003006,GO:0003008,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004672,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006464,GO:0006468,GO:0006518,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006955,GO:0007154,GO:0007165,GO:0007249,GO:0007252,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007292,GO:0007549,GO:0007610,GO:0007611,GO:0007612,GO:0007635,GO:0008023,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008306,GO:0008355,GO:0008607,GO:0009047,GO:0009058,GO:0009059,GO:0009451,GO:0009653,GO:0009790,GO:0009791,GO:0009889,GO:0009987,GO:0009994,GO:0010467,GO:0010468,GO:0010556,GO:0016043,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019207,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019887,GO:0019953,GO:0022412,GO:0022414,GO:0022607,GO:0023052,GO:0030154,GO:0030234,GO:0030334,GO:0030335,GO:0030554,GO:0031248,GO:0031323,GO:0031326,GO:0031399,GO:0031974,GO:0031981,GO:0032268,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032879,GO:0032991,GO:0033588,GO:0034470,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0040012,GO:0040017,GO:0040025,GO:0040029,GO:0042048,GO:0042221,GO:0042325,GO:0042995,GO:0043005,GO:0043025,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043549,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044297,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0044703,GO:0045859,GO:0046483,GO:0048232,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048569,GO:0048598,GO:0048599,GO:0048609,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050877,GO:0050890,GO:0050896,GO:0051171,GO:0051174,GO:0051246,GO:0051252,GO:0051270,GO:0051272,GO:0051338,GO:0051704,GO:0051716,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097458,GO:0097659,GO:0098772,GO:0120025,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902493,GO:1902494,GO:1903506,GO:1990234,GO:2000112,GO:2000145,GO:2000147,GO:2001141	-	ko:K11373	-	-	-	-	ko00000,ko03016,ko03036	-	-	-	IKI3
CH3_k127_6731515_1	886293.Sinac_2565	0.0	1193.0	COG1452@1|root,COG1452@2|Bacteria,2J4VE@203682|Planctomycetes	203682|Planctomycetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6731515_4	697282.Mettu_4058	4.889e-147	475.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1XDPK@135618|Methylococcales	135618|Methylococcales	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
CH3_k127_6731515_2	697282.Mettu_3923	6.425e-273	859.0	COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,1S1Y0@1236|Gammaproteobacteria,1XEI1@135618|Methylococcales	135618|Methylococcales	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CH3_k127_6731515_6	697282.Mettu_0390	1.154e-128	417.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,1S0QR@1236|Gammaproteobacteria,1XFU4@135618|Methylococcales	135618|Methylococcales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CH3_k127_6731515_7	686340.Metal_0575	1.524e-97	322.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,1XDR7@135618|Methylococcales	135618|Methylococcales	KL	DNA RNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
CH3_k127_6731515_0	686340.Metal_0575	0.0	1482.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,1XDR7@135618|Methylococcales	135618|Methylococcales	KL	DNA RNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
CH3_k127_6731515_3	686340.Metal_0574	3.445e-147	469.0	COG4279@1|root,COG4279@2|Bacteria,1N5C3@1224|Proteobacteria,1S187@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
CH3_k127_6731515_5	697282.Mettu_0388	1.979e-144	461.0	COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,1RRQ5@1236|Gammaproteobacteria,1XH0H@135618|Methylococcales	135618|Methylococcales	L	Helix-hairpin-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5,HHH_8
CH3_k127_6735754_5	1101195.Meth11DRAFT_2451	1.042e-08	58.0	COG5635@1|root,COG5635@2|Bacteria,1QZXQ@1224|Proteobacteria	1224|Proteobacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,SIR2_2
CH3_k127_6735754_1	686340.Metal_1454	3.042e-178	565.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1XE5B@135618|Methylococcales	1236|Gammaproteobacteria	E	PFAM Aminotransferase, class I	aspC	-	2.6.1.1,2.6.1.84,3.6.3.21	ko:K00812,ko:K02028,ko:K12252	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00236	R00355,R00694,R00734,R00896,R02433,R02619,R05052,R08197	RC00006,RC00008	ko00000,ko00001,ko00002,ko01000,ko01007,ko02000	3.A.1.3	-	-	ABC_tran,Aminotran_1_2
CH3_k127_6735754_0	686340.Metal_0374	0.0	1049.0	COG0220@1|root,COG0220@2|Bacteria,1QZB6@1224|Proteobacteria,1T52W@1236|Gammaproteobacteria,1XEH1@135618|Methylococcales	135618|Methylococcales	J	tRNA (guanine-N7-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6735754_2	1000565.METUNv1_00267	1.612e-86	300.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,2KUX8@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the peptidase S11 family	pbp	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
CH3_k127_6735754_4	136993.KB900626_gene3051	2.313e-71	244.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,36Y4D@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
CH3_k127_6735754_3	1379270.AUXF01000003_gene3602	1.063e-83	285.0	COG1404@1|root,COG1404@2|Bacteria,1ZV46@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
CH3_k127_6797500_2	697282.Mettu_1204	1.588e-138	445.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1XE2M@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
CH3_k127_6797500_0	857087.Metme_0214	5.691e-214	675.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1XDYK@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
CH3_k127_6797500_7	697282.Mettu_1205	2.38e-48	175.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,1XFED@135618|Methylococcales	135618|Methylococcales	C	arsenate reductase	-	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
CH3_k127_6797500_5	686340.Metal_1715	1.748e-84	285.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1XEUT@135618|Methylococcales	135618|Methylococcales	S	Belongs to the WrbA family	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
CH3_k127_6797500_8	1116472.MGMO_66c00520	3.211e-24	106.0	COG3308@1|root,COG3308@2|Bacteria,1QJQY@1224|Proteobacteria,1THS8@1236|Gammaproteobacteria,1XFIH@135618|Methylococcales	135618|Methylococcales	S	Predicted membrane protein (DUF2069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2069
CH3_k127_6797500_4	697282.Mettu_1208	1.738e-85	290.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1XEXS@135618|Methylococcales	135618|Methylococcales	L	Belongs to the DnaA family. HdA subfamily	-	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
CH3_k127_6797500_1	697282.Mettu_1502	2.702e-163	524.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1XDUF@135618|Methylococcales	135618|Methylococcales	T	TIGRFAM Signal transduction histidine kinase, phosphate regulon sensor PhoR	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA
CH3_k127_6797500_3	697282.Mettu_1503	5.663e-118	382.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1XDJK@135618|Methylococcales	135618|Methylococcales	K	phosphate regulon transcriptional regulatory protein PhoB	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CH3_k127_6797500_6	686340.Metal_3155	4.856e-79	272.0	2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,1S7TX@1236|Gammaproteobacteria,1XFDM@135618|Methylococcales	135618|Methylococcales	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
CH3_k127_6797500_9	1437882.AZRU01000024_gene5728	1.124e-16	81.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1YE5U@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	D	Maf-like protein	yceF	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CH3_k127_6810358_0	686340.Metal_2069	0.0	1700.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XEG1@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
CH3_k127_6854125_3	314285.KT71_11209	4.445e-82	283.0	2DCFR@1|root,2ZDYQ@2|Bacteria,1RB5X@1224|Proteobacteria,1RN4F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6854125_2	1198452.Jab_1c13900	7.528e-85	299.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,2VN0T@28216|Betaproteobacteria,477CK@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	methyltransferase (Contains TPR repeat)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,TPR_1,TPR_10,TPR_11,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
CH3_k127_6854125_1	1183438.GKIL_1925	6.17e-87	304.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1G36K@1117|Cyanobacteria	1117|Cyanobacteria	M	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,TPR_1,TPR_11,TPR_2,TPR_4,TPR_8,Trypsin_2
CH3_k127_6854125_0	296587.XP_002499884.1	1.907e-122	422.0	COG3914@1|root,KOG4626@2759|Eukaryota,37IV9@33090|Viridiplantae,34GWN@3041|Chlorophyta	3041|Chlorophyta	GOT	O-linked N-acetylglucosamine transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_10,TPR_16,TPR_2,TPR_8
CH3_k127_6922804_2	1121015.N789_11200	1.717e-70	261.0	COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,1X33Y@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6922804_1	472759.Nhal_0609	3.344e-122	415.0	COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,1WY6N@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6922804_0	686340.Metal_1551	3.113e-133	435.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1XE33@135618|Methylococcales	135618|Methylococcales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
CH3_k127_6935414_1	697282.Mettu_3309	1.318e-96	319.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,1XE8A@135618|Methylococcales	135618|Methylococcales	P	molybdenum ABC transporter, periplasmic	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
CH3_k127_6935414_0	697282.Mettu_3310	3.113e-97	323.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1XEMM@135618|Methylococcales	135618|Methylococcales	P	ABC transporter permease protein	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
CH3_k127_6935414_2	697282.Mettu_3311	9.125e-38	145.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,1RQCV@1236|Gammaproteobacteria,1XDT6@135618|Methylococcales	135618|Methylococcales	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
CH3_k127_6945742_14	349521.HCH_06741	2.177e-16	80.0	COG3011@1|root,COG3011@2|Bacteria,1N050@1224|Proteobacteria,1S998@1236|Gammaproteobacteria,1XKUW@135619|Oceanospirillales	135619|Oceanospirillales	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
CH3_k127_6945742_7	1116472.MGMO_17c00250	4.068e-72	245.0	COG2193@1|root,COG2193@2|Bacteria,1RF3C@1224|Proteobacteria,1S72I@1236|Gammaproteobacteria,1XF6G@135618|Methylococcales	135618|Methylococcales	P	Ferritin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin
CH3_k127_6945742_3	929558.SMGD1_1375	8.011e-183	584.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42MVS@68525|delta/epsilon subdivisions,2YRUW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CH3_k127_6945742_12	1283300.ATXB01000002_gene2859	1.112e-29	122.0	COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,1SCW1@1236|Gammaproteobacteria,1XFVD@135618|Methylococcales	135618|Methylococcales	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CH3_k127_6945742_8	1116472.MGMO_20c00340	3.715e-52	193.0	COG4648@1|root,COG4648@2|Bacteria,1P3DU@1224|Proteobacteria,1SR7N@1236|Gammaproteobacteria,1XFTB@135618|Methylococcales	135618|Methylococcales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6945742_10	1116472.MGMO_20c00330	1.283e-33	138.0	2FCZ5@1|root,3451T@2|Bacteria,1P1YM@1224|Proteobacteria,1SRQQ@1236|Gammaproteobacteria,1XFQE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6945742_1	686340.Metal_2389	8.275e-224	711.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1XEUP@135618|Methylococcales	135618|Methylococcales	Q	PFAM Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
CH3_k127_6945742_0	1173020.Cha6605_2847	0.0	1119.0	COG0021@1|root,COG0021@2|Bacteria,1G0B5@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the transketolase family	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CH3_k127_6945742_6	857087.Metme_0336	2.632e-134	439.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,1RMPP@1236|Gammaproteobacteria,1XDS2@135618|Methylococcales	135618|Methylococcales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CH3_k127_6945742_9	857087.Metme_0335	1.589e-40	159.0	COG0304@1|root,COG0304@2|Bacteria,1QEDH@1224|Proteobacteria,1SX6F@1236|Gammaproteobacteria,1XGWW@135618|Methylococcales	135618|Methylococcales	IQ	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_2
CH3_k127_6945742_5	857087.Metme_0333	1.664e-144	467.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,1RMNS@1236|Gammaproteobacteria,1XDKP@135618|Methylococcales	135618|Methylococcales	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
CH3_k127_6945742_13	1266909.AUAG01000004_gene2148	4.314e-23	105.0	2EAP9@1|root,334RQ@2|Bacteria,1NDHV@1224|Proteobacteria,1SD8V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6945742_4	857087.Metme_4190	4.283e-161	518.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,1RMNS@1236|Gammaproteobacteria,1XG92@135618|Methylococcales	135618|Methylococcales	C	Lycopene cyclase protein	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
CH3_k127_6945742_2	697282.Mettu_1691	7.389e-191	608.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1XDSD@135618|Methylococcales	135618|Methylococcales	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
CH3_k127_6945742_11	686340.Metal_3751	2.566e-31	125.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1XFMQ@135618|Methylococcales	135618|Methylococcales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
CH3_k127_6945742_15	32042.PstZobell_05573	4.295e-16	78.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1Z0HA@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
CH3_k127_6951349_4	266835.14024661	7.733e-86	289.0	COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,1RCN9@1224|Proteobacteria,2U878@28211|Alphaproteobacteria,43MTM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	CDGSH-type zinc finger. Function unknown.	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,Ferritin-like,zf-CDGSH
CH3_k127_6951349_3	1000565.METUNv1_03199	1.684e-86	289.0	COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,2WFV1@28216|Betaproteobacteria,2KXHE@206389|Rhodocyclales	206389|Rhodocyclales	P	Superoxide dismutase	-	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
CH3_k127_6951349_5	1496688.ER33_06230	1.714e-32	130.0	COG3453@1|root,COG3453@2|Bacteria,1G6UU@1117|Cyanobacteria	1117|Cyanobacteria	S	phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
CH3_k127_6951349_6	1112216.JH594425_gene2748	6.915e-13	71.0	2E9CD@1|root,333K3@2|Bacteria,1NDUJ@1224|Proteobacteria,2UHR7@28211|Alphaproteobacteria,2K81G@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6951349_1	697282.Mettu_4177	1.381e-195	616.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1XEWY@135618|Methylococcales	135618|Methylococcales	H	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CH3_k127_6951349_2	261292.Nit79A3_2358	5.622e-155	494.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VK3S@28216|Betaproteobacteria	28216|Betaproteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CH3_k127_6951349_0	686340.Metal_2185	3.013e-197	619.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RN3S@1236|Gammaproteobacteria,1XDRB@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CH3_k127_6954321_2	697282.Mettu_2298	3.633e-18	89.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XE14@135618|Methylococcales	135618|Methylococcales	M	Sporulation related domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	LysM,SPOR,YkuD
CH3_k127_6954321_0	857087.Metme_3540	0.0	1875.0	28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria,1XDZM@135618|Methylococcales	135618|Methylococcales	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
CH3_k127_6954321_1	882.DVU_2019	3.382e-126	409.0	COG4930@1|root,COG4930@2|Bacteria,1MWGE@1224|Proteobacteria,42N0V@68525|delta/epsilon subdivisions,2WJ2F@28221|Deltaproteobacteria,2M91G@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Putative ATP-dependent Lon protease	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	ChlI,Lon_2,Lon_C,MIT_C
CH3_k127_696521_0	63737.Npun_F6044	3.822e-81	291.0	COG0553@1|root,COG0553@2|Bacteria,1G2YQ@1117|Cyanobacteria,1HME5@1161|Nostocales	1117|Cyanobacteria	L	Superfamily II DNA RNA helicase, SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
CH3_k127_6970797_2	243233.MCA2543	1.119e-117	382.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1XE1A@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
CH3_k127_6970797_4	243233.MCA2709	7.074e-97	328.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1XF1S@135618|Methylococcales	135618|Methylococcales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CH3_k127_6970797_1	697282.Mettu_3594	2.356e-137	442.0	COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,1RN6A@1236|Gammaproteobacteria,1XE2V@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
CH3_k127_6970797_8	697282.Mettu_4290	1.438e-06	50.0	COG4276@1|root,COG4276@2|Bacteria,1N2Z3@1224|Proteobacteria,1SRI2@1236|Gammaproteobacteria,1XGFS@135618|Methylococcales	135618|Methylococcales	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6970797_0	857087.Metme_0935	2.353e-273	850.0	COG0443@1|root,COG0443@2|Bacteria,1Q5TZ@1224|Proteobacteria,1RZCY@1236|Gammaproteobacteria,1XG6Y@135618|Methylococcales	135618|Methylococcales	O	MreB/Mbl protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
CH3_k127_6970797_5	857087.Metme_0934	2.458e-58	209.0	COG0576@1|root,COG0576@2|Bacteria,1MZ1K@1224|Proteobacteria,1S8FS@1236|Gammaproteobacteria,1XGXK@135618|Methylococcales	135618|Methylococcales	O	GrpE	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CH3_k127_6970797_6	857087.Metme_0933	3.43e-24	106.0	COG0484@1|root,COG0484@2|Bacteria,1NHTD@1224|Proteobacteria,1SCW2@1236|Gammaproteobacteria,1XGSZ@135618|Methylococcales	135618|Methylococcales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
CH3_k127_6970797_3	857087.Metme_0932	1.416e-107	366.0	COG0457@1|root,COG0457@2|Bacteria,1R87H@1224|Proteobacteria,1RYZI@1236|Gammaproteobacteria,1XGJ4@135618|Methylococcales	135618|Methylococcales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_6985675_5	1026882.MAMP_01328	7.742e-08	54.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,4608R@72273|Thiotrichales	72273|Thiotrichales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
CH3_k127_6985675_4	857087.Metme_0397	7.551e-30	122.0	2E80T@1|root,332F0@2|Bacteria,1N7RY@1224|Proteobacteria,1SCE8@1236|Gammaproteobacteria,1XFN9@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
CH3_k127_6985675_1	1116472.MGMO_97c00270	3.008e-125	411.0	COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,1XDRU@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized protein conserved in bacteria (DUF2333)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2333
CH3_k127_6985675_0	1116472.MGMO_97c00280	2.039e-126	411.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1XEKX@135618|Methylococcales	135618|Methylococcales	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CH3_k127_6985675_3	697282.Mettu_2196	6.916e-83	281.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S953@1236|Gammaproteobacteria,1XEGU@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
CH3_k127_6985675_2	697282.Mettu_2197	2.89e-99	327.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1XE5F@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
CH3_k127_7014212_1	857087.Metme_3822	0.0	1176.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1XE7C@135618|Methylococcales	135618|Methylococcales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CH3_k127_7014212_0	857087.Metme_3823	0.0	2387.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1XDX0@135618|Methylococcales	135618|Methylococcales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CH3_k127_7014212_5	658187.LDG_8347	7.343e-47	171.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,1JEGD@118969|Legionellales	118969|Legionellales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
CH3_k127_7014212_3	243233.MCA1064	8.98e-81	271.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1XEHY@135618|Methylococcales	135618|Methylococcales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
CH3_k127_7014212_2	686340.Metal_3323	3.287e-123	398.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1XEX5@135618|Methylococcales	135618|Methylococcales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
CH3_k127_7014212_4	1116472.MGMO_66c00080	7.608e-75	252.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1XF18@135618|Methylococcales	135618|Methylococcales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
CH3_k127_7014212_6	1122185.N792_03495	2.671e-30	119.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
CH3_k127_7074320_13	697282.Mettu_1676	5.432e-117	381.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1XEJJ@135618|Methylococcales	135618|Methylococcales	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
CH3_k127_7074320_17	697282.Mettu_1678	7.649e-56	202.0	2AGAT@1|root,316GA@2|Bacteria,1NHNF@1224|Proteobacteria,1SSQF@1236|Gammaproteobacteria,1XF7C@135618|Methylococcales	135618|Methylococcales	S	YcxB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
CH3_k127_7074320_18	1116472.MGMO_143c00070	8.749e-35	136.0	2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,1SD8N@1236|Gammaproteobacteria,1XFAR@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2782)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2782
CH3_k127_7074320_19	686340.Metal_3495	2.747e-16	84.0	COG4701@1|root,COG4701@2|Bacteria,1NHRC@1224|Proteobacteria,1SDJY@1236|Gammaproteobacteria,1XFP6@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
CH3_k127_7074320_7	697282.Mettu_1516	1.003e-164	522.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1XE5R@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
CH3_k127_7074320_4	1116472.MGMO_77c00310	2.919e-177	564.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1XESR@135618|Methylococcales	135618|Methylococcales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
CH3_k127_7074320_1	697282.Mettu_1518	3.691e-219	685.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1XEK3@135618|Methylococcales	135618|Methylococcales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
CH3_k127_7074320_16	686340.Metal_3499	8.899e-57	210.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1XEYV@135618|Methylococcales	135618|Methylococcales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
CH3_k127_7074320_10	686340.Metal_3500	4.831e-140	452.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1XE3P@135618|Methylococcales	135618|Methylococcales	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CH3_k127_7074320_12	697282.Mettu_1521	3.403e-127	412.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1XDKM@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation	murB	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
CH3_k127_7074320_2	697282.Mettu_1522	4.923e-219	695.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1XEMC@135618|Methylococcales	135618|Methylococcales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CH3_k127_7074320_11	686340.Metal_3503	4.788e-137	444.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1XEF4@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
CH3_k127_7074320_8	697282.Mettu_1524	3.76e-164	526.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1XEG0@135618|Methylococcales	135618|Methylococcales	M	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CH3_k127_7074320_6	697282.Mettu_1525	3.51e-171	548.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1XE5G@135618|Methylococcales	135618|Methylococcales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
CH3_k127_7074320_3	697282.Mettu_1526	2.934e-184	580.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XEU1@135618|Methylococcales	135618|Methylococcales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
CH3_k127_7074320_9	697282.Mettu_1527	3.345e-159	514.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1XERH@135618|Methylococcales	135618|Methylococcales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CH3_k127_7074320_5	686340.Metal_3508	2.94e-171	551.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1XE2H@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CH3_k127_7074320_0	697282.Mettu_1529	2.523e-232	733.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1XDU6@135618|Methylococcales	135618|Methylococcales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
CH3_k127_7074320_20	396588.Tgr7_0762	4.682e-09	61.0	COG3116@1|root,COG3116@2|Bacteria,1NI3C@1224|Proteobacteria,1SGSB@1236|Gammaproteobacteria,1WZ00@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
CH3_k127_7074320_14	697282.Mettu_1531	6.147e-115	377.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1XE2P@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
CH3_k127_7074320_15	857087.Metme_0268	1.22e-71	244.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1XF1V@135618|Methylococcales	135618|Methylococcales	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CH3_k127_7074320_21	314287.GB2207_11628	8.464e-09	58.0	2DMTH@1|root,32TKP@2|Bacteria,1N4TE@1224|Proteobacteria,1S9K6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7086408_1	697282.Mettu_4208	4.258e-181	574.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1XE3E@135618|Methylococcales	135618|Methylococcales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003824,GO:0004654,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
CH3_k127_7086408_5	857087.Metme_1288	6.509e-32	126.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,1XFG7@135618|Methylococcales	135618|Methylococcales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
CH3_k127_7086408_2	697282.Mettu_4210	2.526e-98	329.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XDR2@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
CH3_k127_7086408_4	697282.Mettu_4211	4.657e-37	143.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1XFCS@135618|Methylococcales	135618|Methylococcales	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
CH3_k127_7086408_0	243233.MCA1315	1.4e-322	1009.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1XDQX@135618|Methylococcales	135618|Methylococcales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
CH3_k127_7086408_3	697282.Mettu_4213	2.021e-48	177.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1XE32@135618|Methylococcales	135618|Methylococcales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
CH3_k127_713601_3	1283300.ATXB01000001_gene1752	7.972e-22	98.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,1SF0T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CH3_k127_713601_1	857087.Metme_4550	1.407e-156	499.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria,1XE8V@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
CH3_k127_713601_0	857087.Metme_4549	2.636e-313	975.0	COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,1T1GK@1236|Gammaproteobacteria,1XEGE@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CH3_k127_713601_2	697282.Mettu_1845	2.653e-86	293.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1XDQG@135618|Methylococcales	135618|Methylococcales	P	Phosphate transport system permease protein	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
CH3_k127_7183909_0	243233.MCA1012	2.567e-102	342.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1XECS@135618|Methylococcales	135618|Methylococcales	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934,FA_hydroxylase
CH3_k127_7183909_1	697282.Mettu_3362	9.154e-44	162.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1XES2@135618|Methylococcales	135618|Methylococcales	S	PFAM alpha beta hydrolase	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
CH3_k127_719306_0	765910.MARPU_10645	1.148e-45	185.0	COG3829@1|root,COG5002@1|root,COG3829@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2SJ@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
CH3_k127_7193819_1	686340.Metal_2046	1.09e-321	990.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1XDUN@135618|Methylococcales	135618|Methylococcales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CH3_k127_7193819_2	697282.Mettu_2606	7.093e-197	618.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1XEWP@135618|Methylococcales	135618|Methylococcales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CH3_k127_7193819_3	857087.Metme_3298	1.711e-125	406.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1XDJ7@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
CH3_k127_7193819_0	686340.Metal_1357	0.0	1023.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1XE4C@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM ATP-binding cassette protein, ChvD family	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
CH3_k127_7230307_2	1132855.KB913035_gene253	1.129e-46	173.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KM7W@206350|Nitrosomonadales	206350|Nitrosomonadales	T	Sigma-54 interaction domain	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CH3_k127_7230307_0	1121015.N789_01230	3.421e-113	373.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,1S8SK@1236|Gammaproteobacteria,1X5TH@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
CH3_k127_7230307_1	857087.Metme_2390	3.022e-109	369.0	COG2911@1|root,COG2911@2|Bacteria,1NHQB@1224|Proteobacteria,1SVEG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_2
CH3_k127_7270203_1	697282.Mettu_2127	1.731e-56	201.0	COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,1S8SJ@1236|Gammaproteobacteria,1XF8I@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulator	-	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	Rrf2
CH3_k127_7270203_2	296591.Bpro_1180	3.107e-53	202.0	COG3391@1|root,COG3391@2|Bacteria,1QUVX@1224|Proteobacteria,2VITD@28216|Betaproteobacteria,4ABYR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Alkaline phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD,VPEP
CH3_k127_7270203_0	697282.Mettu_3978	0.0	1461.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1XE4N@135618|Methylococcales	135618|Methylococcales	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
CH3_k127_7288519_4	697282.Mettu_0466	5.829e-150	481.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1XE62@135618|Methylococcales	135618|Methylococcales	E	PFAM Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CH3_k127_7288519_9	1116472.MGMO_53c00220	1.5e-74	252.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1XF2E@135618|Methylococcales	135618|Methylococcales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
CH3_k127_7288519_6	697282.Mettu_0468	1.607e-105	351.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1XE3T@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
CH3_k127_7288519_7	686340.Metal_2856	3.292e-94	322.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1XDWJ@135618|Methylococcales	135618|Methylococcales	M	(Lipo)protein	-	-	-	-	-	-	-	-	-	-	-	-	MlaA
CH3_k127_7288519_8	697282.Mettu_0713	1.421e-79	270.0	COG2854@1|root,COG2854@2|Bacteria,1N275@1224|Proteobacteria,1SB2V@1236|Gammaproteobacteria,1XE7V@135618|Methylococcales	135618|Methylococcales	Q	PFAM Toluene tolerance	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
CH3_k127_7288519_2	857087.Metme_3472	1.079e-203	638.0	COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,1RNQ1@1236|Gammaproteobacteria,1XEET@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
CH3_k127_7288519_3	697282.Mettu_0711	1.435e-179	567.0	COG1562@1|root,COG1562@2|Bacteria,1R4ZD@1224|Proteobacteria,1RS93@1236|Gammaproteobacteria,1XE11@135618|Methylococcales	135618|Methylococcales	I	PFAM Squalene phytoene synthase	-	-	2.5.1.21	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	-	R00702,R02872,R06223	RC00362,RC00796,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	SQS_PSY
CH3_k127_7288519_0	697282.Mettu_0710	0.0	1107.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,1S118@1236|Gammaproteobacteria,1XEH0@135618|Methylococcales	135618|Methylococcales	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
CH3_k127_7288519_10	697282.Mettu_0709	3.131e-43	166.0	COG0775@1|root,COG0775@2|Bacteria,1PETT@1224|Proteobacteria,1THNW@1236|Gammaproteobacteria,1XF47@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM Hopanoid-associated phosphorylase	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CH3_k127_7288519_1	857087.Metme_3476	2.316e-241	751.0	COG4992@1|root,COG4992@2|Bacteria,1R6U9@1224|Proteobacteria,1RMRF@1236|Gammaproteobacteria,1XEQV@135618|Methylococcales	135618|Methylococcales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
CH3_k127_7288519_11	686340.Metal_2863	1.433e-28	120.0	COG2372@1|root,COG2372@2|Bacteria,1QJS2@1224|Proteobacteria,1SSRQ@1236|Gammaproteobacteria,1XFMP@135618|Methylococcales	135618|Methylococcales	S	CopC domain	-	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
CH3_k127_7288519_5	697282.Mettu_0705	3.52e-147	475.0	COG1276@1|root,COG1276@2|Bacteria,1MXRN@1224|Proteobacteria,1SKDQ@1236|Gammaproteobacteria,1XDKC@135618|Methylococcales	135618|Methylococcales	P	Copper resistance	-	-	-	ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopD
CH3_k127_7290249_2	1158292.JPOE01000002_gene2394	1.734e-118	389.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2VHFA@28216|Betaproteobacteria	1224|Proteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
CH3_k127_7290249_4	329726.AM1_2608	6.407e-75	258.0	COG0625@1|root,COG0625@2|Bacteria,1G5VJ@1117|Cyanobacteria	1117|Cyanobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_6,GST_N_4
CH3_k127_7290249_6	1116472.MGMO_63c00020	2.13e-20	92.0	2DGNK@1|root,2ZWPU@2|Bacteria,1P5XG@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7290249_1	1158292.JPOE01000002_gene2395	1.237e-193	608.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2VI04@28216|Betaproteobacteria,1KNYP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
CH3_k127_7290249_0	1116472.MGMO_63c00010	5.565e-216	678.0	COG1012@1|root,COG1012@2|Bacteria,1QUBI@1224|Proteobacteria,1T3J1@1236|Gammaproteobacteria,1XG9M@135618|Methylococcales	135618|Methylococcales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
CH3_k127_7290249_5	686340.Metal_3018	6.451e-25	109.0	2BSQX@1|root,32MTR@2|Bacteria,1QJU4@1224|Proteobacteria,1THVH@1236|Gammaproteobacteria,1XFU6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7290249_8	1116472.MGMO_134c00160	2.173e-05	48.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1S5VJ@1236|Gammaproteobacteria,1XE0R@135618|Methylococcales	135618|Methylococcales	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
CH3_k127_7290249_3	269796.Rru_A1492	1.272e-81	288.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,2U0RV@28211|Alphaproteobacteria,2JR1A@204441|Rhodospirillales	204441|Rhodospirillales	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
CH3_k127_7290249_7	1396141.BATP01000056_gene3202	2.143e-06	57.0	COG0472@1|root,COG0472@2|Bacteria,46SNJ@74201|Verrucomicrobia,2IW0H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyl transferase family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_4
CH3_k127_7292672_2	697282.Mettu_1833	2.599e-56	218.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1XDTR@135618|Methylococcales	135618|Methylococcales	G	alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CH3_k127_7292672_0	857087.Metme_3323	3.996e-170	542.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1XE1E@135618|Methylococcales	135618|Methylococcales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CH3_k127_7292672_1	697282.Mettu_1830	1.332e-111	363.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1XDWW@135618|Methylococcales	135618|Methylococcales	E	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
CH3_k127_7298155_0	1245471.PCA10_43500	5.58e-156	518.0	COG1572@1|root,COG2931@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HCBP_related,HemolysinCabind,PPC,Peptidase_M10_C
CH3_k127_7298155_3	1123257.AUFV01000013_gene2764	0.0004132	43.0	COG2801@1|root,COG2801@2|Bacteria,1R6QN@1224|Proteobacteria,1S7GS@1236|Gammaproteobacteria,1X49T@135614|Xanthomonadales	135614|Xanthomonadales	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
CH3_k127_7298155_2	1158756.AQXQ01000011_gene599	1.209e-40	160.0	COG0631@1|root,COG0631@2|Bacteria,1N72S@1224|Proteobacteria,1SBH5@1236|Gammaproteobacteria,1WZC2@135613|Chromatiales	135613|Chromatiales	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
CH3_k127_7298155_1	1215092.PA6_005_00520	4.095e-76	276.0	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,1SYEH@1236|Gammaproteobacteria,1YFQM@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08884,ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	Pkinase
CH3_k127_7331226_1	1396141.BATP01000056_gene3202	1.608e-59	224.0	COG0472@1|root,COG0472@2|Bacteria,46SNJ@74201|Verrucomicrobia,2IW0H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyl transferase family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_4
CH3_k127_7331226_0	622637.KE124774_gene1484	6.874e-60	217.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,36XCM@31993|Methylocystaceae	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	exsA	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CH3_k127_7341163_1	243233.MCA0647	2.5e-38	153.0	COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,1S588@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
CH3_k127_7341163_0	686340.Metal_2703	2.677e-242	755.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1XE53@135618|Methylococcales	135618|Methylococcales	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CH3_k127_7348334_1	686340.Metal_2937	1.835e-314	965.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1XEE5@135618|Methylococcales	135618|Methylococcales	G	SMART Glycosyl hydrolase, family 13, subfamily, catalytic region	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
CH3_k127_7348334_3	697282.Mettu_3116	8.801e-134	432.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1XE9X@135618|Methylococcales	135618|Methylococcales	G	PFAM Carbohydrate purine kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CH3_k127_7348334_6	395961.Cyan7425_4809	7.208e-72	253.0	COG2199@1|root,COG3706@2|Bacteria,1G5BB@1117|Cyanobacteria,3KGBC@43988|Cyanothece	1117|Cyanobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CH3_k127_7348334_4	697282.Mettu_3117	3.545e-126	409.0	COG0561@1|root,COG0561@2|Bacteria,1QDJR@1224|Proteobacteria,1RSEI@1236|Gammaproteobacteria,1XEIB@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	S6PP
CH3_k127_7348334_0	697282.Mettu_3118	0.0	1084.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1XDS7@135618|Methylococcales	135618|Methylococcales	M	Sucrose phosphate synthase, sucrose phosphatase-like	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1,S6PP
CH3_k127_7348334_5	857087.Metme_3206	1.044e-95	316.0	COG0025@1|root,COG1226@1|root,COG0025@2|Bacteria,COG1226@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria,1XG26@135618|Methylococcales	135618|Methylococcales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
CH3_k127_7348334_2	1265502.KB905933_gene1960	6.43e-264	817.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,2VNF8@28216|Betaproteobacteria,4AG4P@80864|Comamonadaceae	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CH3_k127_7348334_11	1158292.JPOE01000002_gene2456	5.263e-07	51.0	COG3335@1|root,COG3335@2|Bacteria,1MW8A@1224|Proteobacteria,2VPNY@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_33
CH3_k127_7348334_8	1268635.Loa_00230	4.716e-31	123.0	COG4679@1|root,COG4679@2|Bacteria,1MZC9@1224|Proteobacteria,1S8WB@1236|Gammaproteobacteria,1JEPD@118969|Legionellales	118969|Legionellales	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
CH3_k127_7348334_7	1116472.MGMO_131c00060	4.069e-48	173.0	COG5606@1|root,COG5606@2|Bacteria,1PQ56@1224|Proteobacteria,1RVP6@1236|Gammaproteobacteria,1XGUG@135618|Methylococcales	135618|Methylococcales	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
CH3_k127_7348334_9	153948.NAL212_2404	1.237e-16	81.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2VKSJ@28216|Betaproteobacteria,373Q7@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Transposase, IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
CH3_k127_7384335_0	243233.MCA0317	7.517e-107	349.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,1S012@1236|Gammaproteobacteria,1XDJS@135618|Methylococcales	135618|Methylococcales	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
CH3_k127_7384335_3	1121451.DESAM_21635	1.368e-42	157.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,42U4W@68525|delta/epsilon subdivisions,2WQ9S@28221|Deltaproteobacteria,2MCV4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
CH3_k127_7384335_2	697282.Mettu_1756	3.454e-78	266.0	COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,1RNQH@1236|Gammaproteobacteria,1XE72@135618|Methylococcales	135618|Methylococcales	K	PFAM Transcriptional regulator, TetR-like, DNA-binding, bacterial archaeal	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
CH3_k127_7384335_1	1116472.MGMO_47c00080	7.217e-80	274.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1XEJB@135618|Methylococcales	135618|Methylococcales	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
CH3_k127_7384335_4	202952.BBLI01000004_gene396	2.693e-31	126.0	2DNQI@1|root,32YKA@2|Bacteria,1P5I3@1224|Proteobacteria,1TNEX@1236|Gammaproteobacteria,3NQFQ@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7390945_4	686340.Metal_3708	6.676e-65	226.0	COG3794@1|root,COG3794@2|Bacteria,1RF7V@1224|Proteobacteria,1S4VA@1236|Gammaproteobacteria,1XG9R@135618|Methylococcales	135618|Methylococcales	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7390945_2	697282.Mettu_2814	5.183e-223	703.0	COG2132@1|root,COG2132@2|Bacteria,1R8SR@1224|Proteobacteria,1SDTA@1236|Gammaproteobacteria,1XERJ@135618|Methylococcales	135618|Methylococcales	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
CH3_k127_7390945_1	697282.Mettu_1869	8.968e-270	835.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
CH3_k127_7390945_0	1116472.MGMO_83c00110	1.068e-296	916.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1XDZD@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
CH3_k127_7390945_3	251221.35211561	1.929e-88	300.0	COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria	1117|Cyanobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CH3_k127_7406580_4	1101190.ARWB01000001_gene1459	0.0001479	46.0	2DRX1@1|root,33DGC@2|Bacteria,1NBK0@1224|Proteobacteria,2UIFZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7406580_3	1116472.MGMO_64c00100	1.192e-29	121.0	2EV48@1|root,33NJ5@2|Bacteria,1NKHY@1224|Proteobacteria,1SJAZ@1236|Gammaproteobacteria,1XFGN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7406580_1	857087.Metme_3252	1.371e-83	283.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1RSHC@1236|Gammaproteobacteria,1XEJZ@135618|Methylococcales	135618|Methylococcales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CH3_k127_7406580_2	1283300.ATXB01000001_gene1041	8.518e-41	162.0	2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1S61M@1236|Gammaproteobacteria,1XGEV@135618|Methylococcales	135618|Methylococcales	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7406580_0	697282.Mettu_0419	9.809e-94	308.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1XDZ8@135618|Methylococcales	135618|Methylococcales	G	TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family	-	-	-	-	-	-	-	-	-	-	-	-	PQQ
CH3_k127_7434234_3	264198.Reut_B3640	8.272e-37	148.0	COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,2VRYZ@28216|Betaproteobacteria,1K7AP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7434234_2	261292.Nit79A3_0231	4.152e-125	428.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,371Z5@32003|Nitrosomonadales	28216|Betaproteobacteria	T	SMART Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
CH3_k127_7434234_1	768671.ThimaDRAFT_3266	2.467e-169	551.0	COG0664@1|root,COG2066@1|root,COG0664@2|Bacteria,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,1WYNM@135613|Chromatiales	135613|Chromatiales	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
CH3_k127_7434234_0	697282.Mettu_2490	0.0	1135.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1XE5Y@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
CH3_k127_7434234_4	1116472.MGMO_114c00080	5.834e-07	52.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RXZ7@1236|Gammaproteobacteria,1XE3M@135618|Methylococcales	135618|Methylococcales	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
CH3_k127_7439037_3	765912.Thimo_2145	3.374e-18	93.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T23Q@1236|Gammaproteobacteria,1WXM7@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CH3_k127_7439037_0	686340.Metal_1983	5.96e-87	293.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RRT6@1236|Gammaproteobacteria,1XFBD@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CH3_k127_7439037_1	335543.Sfum_3616	3.182e-64	238.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,42R8X@68525|delta/epsilon subdivisions,2WN6U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
CH3_k127_7439037_2	1121935.AQXX01000118_gene4935	5.331e-22	104.0	COG1842@1|root,COG1842@2|Bacteria	2|Bacteria	KT	Phage shock protein A	-	-	-	ko:K03615,ko:K03969,ko:K09749,ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,PspA_IM30
CH3_k127_7439037_4	768671.ThimaDRAFT_1459	1.316e-08	64.0	2CFV2@1|root,32UMX@2|Bacteria,1N3YD@1224|Proteobacteria,1SABG@1236|Gammaproteobacteria,1WZ2C@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7451322_11	857087.Metme_0393	5.603e-24	103.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1XDSH@135618|Methylococcales	135618|Methylococcales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
CH3_k127_7451322_2	686340.Metal_0063	2.613e-273	860.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1XDNX@135618|Methylococcales	135618|Methylococcales	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
CH3_k127_7451322_9	105559.Nwat_1975	8.257e-38	144.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria,1WYXG@135613|Chromatiales	135613|Chromatiales	P	Divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
CH3_k127_7451322_8	857087.Metme_1738	9.414e-52	187.0	COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,1S8XU@1236|Gammaproteobacteria,1XF3Y@135618|Methylococcales	135618|Methylococcales	S	PFAM FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
CH3_k127_7451322_10	1116472.MGMO_138c00050	1.212e-25	107.0	2AVGE@1|root,31M8K@2|Bacteria,1QJSA@1224|Proteobacteria,1THTM@1236|Gammaproteobacteria,1XFNV@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CH3_k127_7451322_0	686340.Metal_0067	0.0	1051.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1XEAI@135618|Methylococcales	135618|Methylococcales	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CH3_k127_7451322_1	494416.AYXN01000042_gene1768	0.0	1049.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,3NJUH@468|Moraxellaceae	1236|Gammaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
CH3_k127_7451322_5	1121406.JAEX01000001_gene93	2.241e-110	369.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WKF4@28221|Deltaproteobacteria,2M8KJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CH3_k127_7451322_4	105559.Nwat_0657	1.035e-125	416.0	COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,1S0D6@1236|Gammaproteobacteria,1WY3U@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glycos_transf_1
CH3_k127_7451322_6	390235.PputW619_1412	2.339e-90	307.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,1RPHW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	epimerase dehydratase	wbpV	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CH3_k127_7451322_7	748247.AZKH_3757	2.431e-79	276.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,2VQW6@28216|Betaproteobacteria,2KX61@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyl transferase family 4	-	-	-	ko:K13007	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
CH3_k127_7451322_3	857087.Metme_1198	1.994e-266	832.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,1XEF1@135618|Methylococcales	135618|Methylococcales	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
CH3_k127_7451322_12	1265505.ATUG01000002_gene1332	1.776e-19	91.0	2CC6G@1|root,32Y5Q@2|Bacteria,1N79B@1224|Proteobacteria,42VUW@68525|delta/epsilon subdivisions,2WRRP@28221|Deltaproteobacteria,2MNZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of Unknown Function with PDB structure (DUF3862)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3862
CH3_k127_7455138_1	1116472.MGMO_76c00010	8.556e-60	213.0	28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria,1XDJX@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7455138_0	322710.Avin_40140	1.772e-73	255.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1RS4F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	yjdF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
CH3_k127_7455138_2	686340.Metal_2274	5.292e-44	178.0	COG2885@1|root,COG2911@1|root,COG2982@1|root,COG2885@2|Bacteria,COG2911@2|Bacteria,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XE60@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
CH3_k127_7469298_0	697282.Mettu_2985	1.454e-318	983.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XG74@135618|Methylococcales	135618|Methylococcales	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
CH3_k127_7476688_0	686340.Metal_1598	0.0	1055.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,1RYAA@1236|Gammaproteobacteria,1XEHK@135618|Methylococcales	135618|Methylococcales	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
CH3_k127_7476688_2	1123279.ATUS01000002_gene15	2.338e-135	440.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RPQC@1236|Gammaproteobacteria,1J8BK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
CH3_k127_7476688_1	697282.Mettu_2359	2.021e-140	451.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,1RPYA@1236|Gammaproteobacteria,1XDVA@135618|Methylococcales	135618|Methylococcales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
CH3_k127_7476688_4	857087.Metme_3910	4.659e-29	119.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,1SI3D@1236|Gammaproteobacteria,1XFTN@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
CH3_k127_7476688_3	857087.Metme_3746	2.047e-101	335.0	COG4773@1|root,COG4773@2|Bacteria,1QVK7@1224|Proteobacteria,1T53A@1236|Gammaproteobacteria,1XDUB@135618|Methylococcales	135618|Methylococcales	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
CH3_k127_7482399_0	243233.MCA2606	2.152e-276	858.0	COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1XG73@135618|Methylococcales	135618|Methylococcales	G	Starch synthase catalytic domain	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
CH3_k127_7482399_2	1283300.ATXB01000001_gene664	4.713e-177	564.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1XFWC@135618|Methylococcales	135618|Methylococcales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	hDGE_amylase
CH3_k127_7482399_1	686340.Metal_3567	3.857e-204	640.0	COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,1RMNA@1236|Gammaproteobacteria,1XDP6@135618|Methylococcales	135618|Methylococcales	EG	Belongs to the IlvD Edd family	edd	-	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
CH3_k127_7484415_1	909663.KI867150_gene2891	1.858e-89	306.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,2MQWV@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
CH3_k127_7484415_0	1026882.MAMP_02424	1.685e-111	364.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoketolase	xfp	GO:0003674,GO:0003824,GO:0008150,GO:0009758	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
CH3_k127_7508100_10	1286631.X805_28070	2.829e-45	165.0	COG0582@1|root,COG0582@2|Bacteria,1R21C@1224|Proteobacteria,2WI7T@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
CH3_k127_7508100_11	443143.GM18_4371	1.621e-38	146.0	COG1396@1|root,COG1396@2|Bacteria,1N0DD@1224|Proteobacteria	1224|Proteobacteria	K	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CH3_k127_7508100_3	697282.Mettu_0906	1.65e-138	446.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1XDIZ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CH3_k127_7508100_8	697282.Mettu_0905	1.375e-62	222.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1XF41@135618|Methylococcales	135618|Methylococcales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
CH3_k127_7508100_6	857087.Metme_0622	9.106e-78	262.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1XF3G@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
CH3_k127_7508100_1	243233.MCA1656	4.953e-187	589.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1XDY4@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
CH3_k127_7508100_4	697282.Mettu_0902	3.717e-103	338.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1XEWE@135618|Methylococcales	135618|Methylococcales	H	riboflavin synthase, alpha subunit	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
CH3_k127_7508100_2	697282.Mettu_0901	1.72e-142	460.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1XEHV@135618|Methylococcales	135618|Methylococcales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
CH3_k127_7508100_7	1116472.MGMO_126c00290	2.496e-67	232.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1XF1Z@135618|Methylococcales	135618|Methylococcales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
CH3_k127_7508100_9	857087.Metme_0616	1.161e-60	217.0	COG0235@1|root,COG0235@2|Bacteria,1N2XS@1224|Proteobacteria,1S573@1236|Gammaproteobacteria,1XFBZ@135618|Methylococcales	135618|Methylococcales	G	PFAM Class II aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
CH3_k127_7508100_12	686340.Metal_0270	1.735e-33	130.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1XFHQ@135618|Methylococcales	135618|Methylococcales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
CH3_k127_7508100_5	697282.Mettu_1261	6.967e-94	314.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1XDJP@135618|Methylococcales	135618|Methylococcales	S	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
CH3_k127_7508100_0	857087.Metme_2755	1.164e-245	766.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1XDRQ@135618|Methylococcales	135618|Methylococcales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
CH3_k127_7508100_13	697282.Mettu_1303	3.331e-32	131.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XEEP@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
CH3_k127_7574149_1	243233.MCA2606	8.405e-31	133.0	COG0297@1|root,COG0297@2|Bacteria,1P7F2@1224|Proteobacteria,1RZVJ@1236|Gammaproteobacteria,1XG73@135618|Methylococcales	135618|Methylococcales	G	Starch synthase catalytic domain	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
CH3_k127_7574149_0	697282.Mettu_0408	2.104e-248	776.0	COG1543@1|root,COG1543@2|Bacteria,1R5SN@1224|Proteobacteria,1S1IY@1236|Gammaproteobacteria,1XEJV@135618|Methylococcales	135618|Methylococcales	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
CH3_k127_7574149_2	686340.Metal_2158	2.158e-07	60.0	COG3330@1|root,COG3330@2|Bacteria,1P8BB@1224|Proteobacteria,1SV0Y@1236|Gammaproteobacteria,1XGM5@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4912)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4912
CH3_k127_7738801_7	697282.Mettu_3543	1.779e-12	67.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1XF3T@135618|Methylococcales	135618|Methylococcales	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
CH3_k127_7738801_6	243233.MCA1231	7.186e-27	122.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1XFEG@135618|Methylococcales	135618|Methylococcales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
CH3_k127_7738801_4	686340.Metal_2822	2.828e-95	316.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1XDUJ@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
CH3_k127_7738801_1	686340.Metal_2823	8.148e-111	362.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1XETJ@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
CH3_k127_7738801_3	1283300.ATXB01000001_gene1076	2.179e-98	334.0	COG3336@1|root,COG3336@2|Bacteria,1RAW2@1224|Proteobacteria,1S3HN@1236|Gammaproteobacteria,1XGPI@135618|Methylococcales	135618|Methylococcales	S	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
CH3_k127_7738801_2	697282.Mettu_0335	4.687e-100	338.0	COG0741@1|root,COG0741@2|Bacteria,1MWRW@1224|Proteobacteria,1S084@1236|Gammaproteobacteria,1XEU5@135618|Methylococcales	135618|Methylococcales	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7738801_5	857087.Metme_4096	4.522e-63	222.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,1XF19@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
CH3_k127_7738801_0	395493.BegalDRAFT_3036	2.971e-211	671.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,45ZXG@72273|Thiotrichales	72273|Thiotrichales	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CH3_k127_7739795_6	1117108.PAALTS15_13052	1.071e-30	129.0	COG1105@1|root,COG1105@2|Bacteria,1TR9H@1239|Firmicutes,4HAGR@91061|Bacilli,274KT@186822|Paenibacillaceae	91061|Bacilli	H	Belongs to the carbohydrate kinase PfkB family. LacC subfamily	lacC	-	2.7.1.144	ko:K00917	ko00052,ko01100,map00052,map01100	-	R03236	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CH3_k127_7739795_2	686340.Metal_0922	9.018e-158	503.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,1RQYE@1236|Gammaproteobacteria,1XEG4@135618|Methylococcales	135618|Methylococcales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CH3_k127_7739795_4	697282.Mettu_0131	4.933e-80	274.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1XDVG@135618|Methylococcales	135618|Methylococcales	S	Competence protein	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
CH3_k127_7739795_0	697282.Mettu_0132	4.48e-176	556.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1XDXY@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
CH3_k127_7739795_1	697282.Mettu_0133	4.654e-167	533.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1XE9P@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CH3_k127_7739795_3	686340.Metal_2957	2.976e-82	281.0	COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,1XF2Y@135618|Methylococcales	135618|Methylococcales	S	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
CH3_k127_7739795_5	697282.Mettu_0135	1.708e-70	247.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1XF4S@135618|Methylococcales	135618|Methylococcales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
CH3_k127_7739795_7	1112274.KI911560_gene1544	1.653e-27	114.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2VR4C@28216|Betaproteobacteria,2KMNW@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
CH3_k127_7739795_8	1384054.N790_05610	2.161e-08	57.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1X3VC@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
CH3_k127_7759820_0	1366050.N234_35005	3.32e-206	650.0	COG4320@1|root,COG4320@2|Bacteria,1N6EW@1224|Proteobacteria,2VN9A@28216|Betaproteobacteria,1K2DQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
CH3_k127_7759820_4	550540.Fbal_2114	2.873e-11	65.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CH3_k127_7759820_3	583355.Caka_1352	1.518e-17	83.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CH3_k127_7759820_1	617140.AJZE01000090_gene4238	1.602e-160	522.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1XVZK@135623|Vibrionales	135623|Vibrionales	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CH3_k127_7759820_2	566466.NOR53_2087	9.967e-29	119.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RYI9@1236|Gammaproteobacteria,1J9PP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
CH3_k127_7847843_1	857087.Metme_0783	0.0	1049.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1XDP7@135618|Methylococcales	135618|Methylococcales	F	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CH3_k127_7847843_0	686340.Metal_2150	0.0	1420.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1XDPU@135618|Methylococcales	135618|Methylococcales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CH3_k127_7847843_2	857087.Metme_1304	1.068e-14	76.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1XF71@135618|Methylococcales	135618|Methylococcales	K	transcriptional regulator, Crp	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CH3_k127_7853704_2	857087.Metme_0368	1.201e-46	170.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1XE5F@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
CH3_k127_7853704_0	857087.Metme_0367	3.434e-211	661.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1XDQE@135618|Methylococcales	135618|Methylococcales	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CH3_k127_7853704_1	697282.Mettu_2537	3.46e-78	264.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1XF0C@135618|Methylococcales	135618|Methylococcales	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CH3_k127_7896877_1	697282.Mettu_0735	1.027e-20	94.0	2ETMS@1|root,33M5I@2|Bacteria,1NIHS@1224|Proteobacteria,1SH1Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1902)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1902
CH3_k127_7896877_2	652103.Rpdx1_4159	2.485e-12	68.0	2E3J6@1|root,32YHK@2|Bacteria,1NEFW@1224|Proteobacteria,2UKBP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CH3_k127_7896877_3	1121342.AUCO01000004_gene571	4.142e-07	59.0	COG1434@1|root,COG1434@2|Bacteria,1VA42@1239|Firmicutes,24HKK@186801|Clostridia,36HJ1@31979|Clostridiaceae	186801|Clostridia	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
CH3_k127_7896877_0	90813.JQMT01000001_gene684	2.778e-57	205.0	COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,1T2CN@1236|Gammaproteobacteria,461HV@72273|Thiotrichales	72273|Thiotrichales	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CH3_k127_7907733_0	1173020.Cha6605_1920	7.896e-166	529.0	COG2211@1|root,COG2211@2|Bacteria,1GQN5@1117|Cyanobacteria	1117|Cyanobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CH3_k127_7907733_1	290317.Cpha266_2057	1.131e-86	291.0	28MI1@1|root,2ZAUV@2|Bacteria	2|Bacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CH3_k127_7907733_2	290317.Cpha266_2056	8.021e-40	151.0	2E8SU@1|root,3333K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7907733_3	1255043.TVNIR_2275	1.193e-17	85.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1WY9M@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CH3_k127_7944488_0	697282.Mettu_0443	0.0	1305.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1XEDV@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CH3_k127_7944488_2	306281.AJLK01000091_gene3531	3.092e-88	295.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1JJDA@1189|Stigonemataceae	1117|Cyanobacteria	O	Peptide methionine sulfoxide reductase	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
CH3_k127_7944488_8	686340.Metal_3565	1.467e-11	69.0	29974@1|root,2ZWAF@2|Bacteria,1P9UB@1224|Proteobacteria,1SV8K@1236|Gammaproteobacteria,1XFXX@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7944488_5	697282.Mettu_2504	6.976e-36	139.0	2FJ61@1|root,34AW5@2|Bacteria,1P2US@1224|Proteobacteria,1SRD0@1236|Gammaproteobacteria,1XFN0@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7944488_9	1449063.JMLS01000016_gene953	5.754e-06	49.0	2EG8N@1|root,33A0G@2|Bacteria,1VMHK@1239|Firmicutes,4HSIH@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7944488_6	926560.KE387023_gene2058	7.746e-31	127.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CH3_k127_7944488_7	857087.Metme_1609	3.103e-18	84.0	29B2J@1|root,2ZY18@2|Bacteria,1P4DG@1224|Proteobacteria,1SU52@1236|Gammaproteobacteria,1XFW5@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_7944488_3	686340.Metal_2126	4.843e-84	281.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,1S6Y2@1236|Gammaproteobacteria,1XF7A@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase, subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
CH3_k127_7944488_1	686340.Metal_2127	2.18e-321	987.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,1S0H0@1236|Gammaproteobacteria,1XEM1@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c oxidase, subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
CH3_k127_7944488_4	686340.Metal_2128	3.994e-81	280.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1XF3X@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
CH3_k127_8009982_6	857087.Metme_0889	3.841e-20	94.0	29NZI@1|root,309XP@2|Bacteria,1QJR3@1224|Proteobacteria,1THS9@1236|Gammaproteobacteria,1XFIJ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8009982_2	857087.Metme_4370	1.631e-129	421.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria,1XE9V@135618|Methylococcales	135618|Methylococcales	KLT	Tyrosine-protein kinase, subgroup, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CH3_k127_8009982_3	857087.Metme_4369	8.341e-104	345.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1XEJ6@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
CH3_k127_8009982_4	83406.HDN1F_30860	2.073e-41	159.0	COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria,1J6XX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	Belongs to the N-Me-Phe pilin family	pilA1	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
CH3_k127_8009982_0	697282.Mettu_1198	1.314e-169	538.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1XEFW@135618|Methylococcales	135618|Methylococcales	F	AIR synthase related protein, C-terminal	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CH3_k127_8009982_1	697282.Mettu_3598	1.637e-142	458.0	COG3272@1|root,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1XEGF@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
CH3_k127_8009982_5	472759.Nhal_1636	5.043e-21	99.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WXH8@135613|Chromatiales	135613|Chromatiales	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
CH3_k127_8028248_2	686340.Metal_1174	6.12e-43	158.0	2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,1S9N4@1236|Gammaproteobacteria,1XFN4@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8028248_3	1120970.AUBZ01000001_gene3665	2.387e-24	105.0	COG3098@1|root,COG3098@2|Bacteria,1N7AG@1224|Proteobacteria,1SCXJ@1236|Gammaproteobacteria,468CS@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	yqcC	GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF446
CH3_k127_8028248_0	697282.Mettu_4256	1.785e-130	424.0	COG3391@1|root,COG3391@2|Bacteria,1MXJJ@1224|Proteobacteria,1SZ16@1236|Gammaproteobacteria,1XE8Q@135618|Methylococcales	135618|Methylococcales	S	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
CH3_k127_8028248_1	686340.Metal_1172	3.124e-69	240.0	COG3832@1|root,COG3832@2|Bacteria,1RD9A@1224|Proteobacteria,1S95U@1236|Gammaproteobacteria,1XF1E@135618|Methylococcales	135618|Methylococcales	S	PFAM Polyketide cyclase dehydrase	-	-	-	ko:K16260	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001	-	-	-	Polyketide_cyc2
CH3_k127_8028248_5	1469607.KK073769_gene5954	2.681e-05	51.0	COG3415@1|root,COG3415@2|Bacteria,1GAAQ@1117|Cyanobacteria	1117|Cyanobacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_33
CH3_k127_8028248_4	686340.Metal_0525	7.466e-20	91.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,1XEPF@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
CH3_k127_8052821_2	243233.MCA1104	1.22e-50	188.0	COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,1S62V@1236|Gammaproteobacteria,1XF83@135618|Methylococcales	135618|Methylococcales	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CH3_k127_8052821_1	1116472.MGMO_26c00150	5.453e-61	213.0	COG0590@1|root,COG0590@2|Bacteria,1RHM4@1224|Proteobacteria,1S4RE@1236|Gammaproteobacteria,1XF6P@135618|Methylococcales	135618|Methylococcales	FJ	deaminase zinc-binding	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
CH3_k127_8052821_0	697282.Mettu_1201	1.223e-193	607.0	COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1XE2G@135618|Methylococcales	135618|Methylococcales	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metAS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	HTS
CH3_k127_8052821_3	485913.Krac_9564	1.289e-42	163.0	COG3548@1|root,COG3548@2|Bacteria	2|Bacteria	S	protein homotetramerization	-	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016043,GO:0022607,GO:0022803,GO:0022838,GO:0022840,GO:0022841,GO:0022842,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0043933,GO:0044085,GO:0046873,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0098655,GO:0098660,GO:0098662	-	-	-	-	-	-	-	-	-	-	DUF1211
CH3_k127_8052821_8	306281.AJLK01000216_gene815	0.0002036	47.0	COG4467@1|root,COG4467@2|Bacteria	2|Bacteria	L	Involved in initiation control of chromosome replication	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
CH3_k127_8052821_4	1444310.JANV01000170_gene2322	1.446e-23	106.0	COG4467@1|root,COG4467@2|Bacteria,1VK8R@1239|Firmicutes,4HYEG@91061|Bacilli	91061|Bacilli	S	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,zf-IS66
CH3_k127_8052821_5	1397528.Q671_16785	6.025e-08	58.0	COG4467@1|root,COG4467@2|Bacteria,1QW8C@1224|Proteobacteria,1S2JX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
CH3_k127_8052821_7	1121403.AUCV01000064_gene4129	4.733e-05	48.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2WIJ0@28221|Deltaproteobacteria,2MITQ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
CH3_k127_8052821_6	243233.MCA0110	4.127e-06	48.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1XEVY@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
CH3_k127_8092621_1	697282.Mettu_2686	7.923e-59	205.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1XDZ5@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
CH3_k127_8092621_2	857087.Metme_3063	3.201e-47	175.0	COG2888@1|root,COG2888@2|Bacteria,1PBSP@1224|Proteobacteria,1SWH2@1236|Gammaproteobacteria,1XF87@135618|Methylococcales	135618|Methylococcales	J	Zinc-ribbon containing domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1451
CH3_k127_8092621_0	697282.Mettu_2684	3.054e-130	420.0	COG1192@1|root,COG1192@2|Bacteria,1MVEZ@1224|Proteobacteria,1RPWA@1236|Gammaproteobacteria,1XDKA@135618|Methylococcales	135618|Methylococcales	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CH3_k127_8112906_2	909663.KI867150_gene1747	4.274e-125	402.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,2MQUJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CH3_k127_8112906_1	686340.Metal_3057	5.238e-142	457.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNR@1236|Gammaproteobacteria,1XDM7@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
CH3_k127_8112906_0	1304883.KI912532_gene2972	9.92e-201	628.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,2KV8P@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CH3_k127_8112906_5	1283300.ATXB01000001_gene343	1.725e-37	144.0	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1XFGE@135618|Methylococcales	135618|Methylococcales	P	Part of a sulfur-relay system	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
CH3_k127_8112906_4	857087.Metme_1820	7.855e-44	161.0	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,1S8TD@1236|Gammaproteobacteria,1XFJT@135618|Methylococcales	135618|Methylococcales	U	PFAM Small Multidrug Resistance protein	-	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
CH3_k127_8112906_3	857087.Metme_0513	2.481e-99	330.0	COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,1S0KZ@1236|Gammaproteobacteria,1XEQ4@135618|Methylococcales	135618|Methylococcales	S	Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
CH3_k127_8112906_6	765913.ThidrDRAFT_1085	3.522e-05	46.0	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,1WX7S@135613|Chromatiales	135613|Chromatiales	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
CH3_k127_8113727_2	1283300.ATXB01000001_gene1937	2.726e-46	173.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,1RNG8@1236|Gammaproteobacteria,1XE21@135618|Methylococcales	135618|Methylococcales	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
CH3_k127_8113727_1	1116472.MGMO_143c00090	1.83e-104	343.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1RPB1@1236|Gammaproteobacteria,1XF7R@135618|Methylococcales	135618|Methylococcales	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
CH3_k127_8113727_0	697282.Mettu_2382	2.625e-197	622.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria,1XEVW@135618|Methylococcales	135618|Methylococcales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
CH3_k127_8115773_3	640081.Dsui_0466	2.627e-45	167.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,2KWP5@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CH3_k127_8115773_0	1045856.EcWSU1_00112	4.291e-107	359.0	COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,1RQE3@1236|Gammaproteobacteria,3X14V@547|Enterobacter	1236|Gammaproteobacteria	M	PFAM Glycosyl transferase, group 1	rfaG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	iSDY_1059.SDY_4061	Glyco_transf_4,Glycos_transf_1
CH3_k127_8115773_1	1123487.KB892857_gene2355	1.969e-101	342.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VRSM@28216|Betaproteobacteria,2KVQV@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
CH3_k127_8115773_2	1122604.JONR01000037_gene4238	2.868e-83	283.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,1RQUH@1236|Gammaproteobacteria,1X51A@135614|Xanthomonadales	135614|Xanthomonadales	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CH3_k127_8115773_4	323848.Nmul_A2658	0.0005346	44.0	2CCJR@1|root,2ZCU4@2|Bacteria,1RC7F@1224|Proteobacteria,2W4MN@28216|Betaproteobacteria,3720D@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8121203_1	388467.A19Y_2489	3.211e-31	126.0	COG3744@1|root,COG3744@2|Bacteria,1G89C@1117|Cyanobacteria,1HCPH@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CH3_k127_8121203_0	697282.Mettu_0978	1.314e-180	567.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1XDYW@135618|Methylococcales	135618|Methylococcales	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
CH3_k127_8154820_1	522306.CAP2UW1_3222	2.981e-186	589.0	COG4924@1|root,COG4924@2|Bacteria,1P11B@1224|Proteobacteria,2VKST@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria N-term (DUF3322)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2220,DUF3322
CH3_k127_8154820_0	686340.Metal_2130	1.43e-220	687.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1T9DW@1236|Gammaproteobacteria,1XG6V@135618|Methylococcales	135618|Methylococcales	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
CH3_k127_8154820_3	686340.Metal_2129	2.287e-53	188.0	COG1359@1|root,COG1359@2|Bacteria,1RI7W@1224|Proteobacteria,1TKPU@1236|Gammaproteobacteria,1XGHN@135618|Methylococcales	135618|Methylococcales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
CH3_k127_8154820_2	697282.Mettu_3583	9.425e-74	250.0	COG0741@1|root,COG0741@2|Bacteria,1Q8YR@1224|Proteobacteria,1THJC@1236|Gammaproteobacteria,1XEHA@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
CH3_k127_8170671_4	187303.BN69_3412	1.74e-08	56.0	COG3637@1|root,COG3637@2|Bacteria,1QQJF@1224|Proteobacteria,2VGHD@28211|Alphaproteobacteria,36ZRS@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp,OMP_b-brl
CH3_k127_8170671_3	1116472.MGMO_144c00130	1.351e-18	86.0	COG3637@1|root,COG3637@2|Bacteria,1QQJF@1224|Proteobacteria,1THXI@1236|Gammaproteobacteria,1XFZ2@135618|Methylococcales	135618|Methylococcales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CH3_k127_8170671_1	243233.MCA2598	1.263e-191	602.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1XE2A@135618|Methylococcales	135618|Methylococcales	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CH3_k127_8170671_0	1116472.MGMO_45c00580	9.449e-220	690.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1XEMY@135618|Methylococcales	135618|Methylococcales	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
CH3_k127_8170671_2	1283300.ATXB01000001_gene1892	1.031e-27	118.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1XDNM@135618|Methylococcales	135618|Methylococcales	CEH	2 iron, 2 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
CH3_k127_8170799_0	697282.Mettu_3973	1.826e-111	363.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,1RPTD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase, gamma subunit	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
CH3_k127_8170799_1	857087.Metme_3420	5.762e-83	285.0	2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,1XEFQ@135618|Methylococcales	135618|Methylococcales	S	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CH3_k127_81858_0	243233.MCA1421	0.0	1330.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1XDSN@135618|Methylococcales	135618|Methylococcales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CH3_k127_81858_1	857087.Metme_1877	2.994e-155	496.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1XDMK@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
CH3_k127_8200673_3	1116472.MGMO_44c00140	4.7e-30	123.0	COG2314@1|root,COG2314@2|Bacteria,1QJRW@1224|Proteobacteria,1THT2@1236|Gammaproteobacteria,1XFM9@135618|Methylococcales	135618|Methylococcales	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
CH3_k127_8200673_1	686340.Metal_0187	4.99e-45	172.0	COG0589@1|root,COG0589@2|Bacteria,1RHE6@1224|Proteobacteria,1RVW2@1236|Gammaproteobacteria,1XFEW@135618|Methylococcales	135618|Methylococcales	T	Universal stress protein	-	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
CH3_k127_8200673_2	697282.Mettu_1675	9.46e-33	132.0	2DRM4@1|root,33C8W@2|Bacteria,1NQ8K@1224|Proteobacteria,1SGVH@1236|Gammaproteobacteria,1XFRG@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8200673_0	686340.Metal_0189	8.467e-76	258.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1XEJJ@135618|Methylococcales	135618|Methylococcales	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
CH3_k127_8201803_3	686340.Metal_2175	1.879e-101	334.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,1RS5K@1236|Gammaproteobacteria,1XF6A@135618|Methylococcales	135618|Methylococcales	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
CH3_k127_8201803_7	1120936.KB907216_gene3914	2.39e-40	161.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4EGC3@85012|Streptosporangiales	201174|Actinobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
CH3_k127_8201803_1	686340.Metal_0056	1.095e-182	580.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1XERD@135618|Methylococcales	135618|Methylococcales	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
CH3_k127_8201803_6	686340.Metal_0057	1.609e-43	166.0	COG1273@1|root,COG1273@2|Bacteria,1MWCU@1224|Proteobacteria,1S892@1236|Gammaproteobacteria,1XGZP@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426
CH3_k127_8201803_2	686340.Metal_0058	1.261e-119	391.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1XDJ3@135618|Methylococcales	135618|Methylococcales	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
CH3_k127_8201803_0	697282.Mettu_2634	3.888e-255	790.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1XEJ4@135618|Methylococcales	135618|Methylococcales	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CH3_k127_8201803_5	857087.Metme_1743	8.406e-56	198.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1XF4V@135618|Methylococcales	135618|Methylococcales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
CH3_k127_8201803_4	857087.Metme_1742	4.624e-68	237.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1XF74@135618|Methylococcales	135618|Methylococcales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
CH3_k127_8201803_9	1121374.KB891575_gene876	5.133e-12	79.0	2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8201803_8	243233.MCA0562	8.232e-37	143.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1XFCP@135618|Methylococcales	135618|Methylococcales	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
CH3_k127_8201803_10	697282.Mettu_0186	8.56e-11	62.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RP0D@1236|Gammaproteobacteria,1XE04@135618|Methylococcales	135618|Methylococcales	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
CH3_k127_8224533_7	857087.Metme_2628	2.201e-100	333.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1XDSZ@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
CH3_k127_8224533_2	857087.Metme_2629	8.224e-225	700.0	COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,1RMGH@1236|Gammaproteobacteria,1XE40@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
CH3_k127_8224533_3	697282.Mettu_4223	5.449e-218	684.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,1XDP1@135618|Methylococcales	135618|Methylococcales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	-	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
CH3_k127_8224533_0	697282.Mettu_4056	1.711e-298	922.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1XEMX@135618|Methylococcales	135618|Methylococcales	J	Glutamyl glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
CH3_k127_8224533_10	335283.Neut_1023	2.799e-06	53.0	2E80T@1|root,332F0@2|Bacteria,1N7RY@1224|Proteobacteria,2VX4M@28216|Betaproteobacteria,373MK@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
CH3_k127_8224533_8	697282.Mettu_1366	1.847e-72	251.0	2E7KN@1|root,3322N@2|Bacteria,1N6FH@1224|Proteobacteria,1SSF1@1236|Gammaproteobacteria,1XF9V@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1097)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1097
CH3_k127_8224533_5	1298593.TOL_0839	1.7e-126	414.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria,1XJGZ@135619|Oceanospirillales	135619|Oceanospirillales	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CH3_k127_8224533_1	1121374.KB891586_gene2672	6.445e-248	775.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
CH3_k127_8224533_6	686340.Metal_2754	1.61e-119	398.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1XDXK@135618|Methylococcales	135618|Methylococcales	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
CH3_k127_8224533_9	686340.Metal_2657	3.489e-50	182.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1XFAT@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family UPF0079, ATPase bacteria	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
CH3_k127_8224533_4	697282.Mettu_4346	1.112e-185	592.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1XEGQ@135618|Methylococcales	135618|Methylococcales	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
CH3_k127_8230501_3	41431.PCC8801_2959	2.754e-11	63.0	COG1451@1|root,COG1451@2|Bacteria,1G1B3@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
CH3_k127_8230501_1	686340.Metal_2160	7.524e-100	330.0	2DN4B@1|root,32VFQ@2|Bacteria,1REFD@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
CH3_k127_8230501_0	857087.Metme_3278	4.72e-178	565.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RQ2G@1236|Gammaproteobacteria,1XDIS@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CH3_k127_8237128_5	349521.HCH_00947	4.78e-83	287.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T23Q@1236|Gammaproteobacteria,1XRKI@135619|Oceanospirillales	135619|Oceanospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CH3_k127_8237128_2	640081.Dsui_1429	3.359e-153	514.0	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV9J@206389|Rhodocyclales	206389|Rhodocyclales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_9,dCache_1
CH3_k127_8237128_4	1246626.BleG1_2365	1.737e-86	293.0	COG0189@1|root,COG0189@2|Bacteria,1TWCJ@1239|Firmicutes,4HCWW@91061|Bacilli,1ZDUV@1386|Bacillus	91061|Bacilli	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
CH3_k127_8237128_3	697282.Mettu_2833	7.417e-134	432.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1XE9F@135618|Methylococcales	135618|Methylococcales	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
CH3_k127_8237128_1	697282.Mettu_2832	2.936e-164	526.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RPE8@1236|Gammaproteobacteria,1XDW4@135618|Methylococcales	135618|Methylococcales	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
CH3_k127_8237128_6	697282.Mettu_2831	1.161e-76	261.0	COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1XEY6@135618|Methylococcales	135618|Methylococcales	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
CH3_k127_8237128_0	686340.Metal_1402	2.378e-271	847.0	COG2132@1|root,COG2132@2|Bacteria,1R8SR@1224|Proteobacteria,1RUEX@1236|Gammaproteobacteria,1XEFZ@135618|Methylococcales	135618|Methylococcales	Q	PFAM Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
CH3_k127_825975_2	1183438.GKIL_2340	3.353e-09	60.0	COG1376@1|root,COG1376@2|Bacteria,1G4ZS@1117|Cyanobacteria	1117|Cyanobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
CH3_k127_825975_3	1129374.AJE_13769	6.808e-07	53.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,1RPJM@1236|Gammaproteobacteria,466PX@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CH3_k127_825975_0	697282.Mettu_2037	5.372e-107	357.0	COG2334@1|root,COG2334@2|Bacteria,1Q18Y@1224|Proteobacteria,1RR8Y@1236|Gammaproteobacteria,1XEQS@135618|Methylococcales	135618|Methylococcales	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CH3_k127_825975_1	686340.Metal_3657	6.112e-89	297.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1XF0E@135618|Methylococcales	135618|Methylococcales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
CH3_k127_8273586_3	686340.Metal_0047	8.376e-74	252.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,1XF2R@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
CH3_k127_8273586_0	1122165.AUHS01000012_gene2815	0.0	1550.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1JDFS@118969|Legionellales	118969|Legionellales	P	AcrB/AcrD/AcrF family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
CH3_k127_8273586_2	1283300.ATXB01000001_gene777	3.254e-89	298.0	COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,1RQ3M@1236|Gammaproteobacteria,1XG51@135618|Methylococcales	135618|Methylococcales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
CH3_k127_8273586_1	1230343.CANP01000050_gene3774	4.673e-121	401.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,1JE1A@118969|Legionellales	118969|Legionellales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	cebB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	HlyD_D23,HlyD_D4
CH3_k127_8273586_4	272624.lpg1094	1.779e-12	67.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1JCMG@118969|Legionellales	118969|Legionellales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CH3_k127_8275807_1	1163617.SCD_n02864	6.779e-67	235.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria	28216|Betaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CH3_k127_8275807_2	118005.AWNK01000007_gene644	1.544e-17	96.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
CH3_k127_8275807_0	697282.Mettu_1855	1.877e-139	454.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XDPG@135618|Methylococcales	135618|Methylococcales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
CH3_k127_8315139_1	1232410.KI421421_gene3745	4.173e-49	181.0	COG4653@1|root,COG4653@2|Bacteria,1MWMB@1224|Proteobacteria,42UPY@68525|delta/epsilon subdivisions,2WQZZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
CH3_k127_8315139_0	547045.NEISICOT_01398	7.686e-69	244.0	COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,2VKKT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phage portal protein, lambda family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal_2
CH3_k127_8327810_3	697282.Mettu_0289	2.224e-191	606.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,1RSI9@1236|Gammaproteobacteria,1XFZ3@135618|Methylococcales	135618|Methylococcales	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	-	-	-	-	-	-	-	-	-	PGA_cap
CH3_k127_8327810_14	522306.CAP2UW1_1124	2.783e-18	86.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,2VJKF@28216|Betaproteobacteria	28216|Betaproteobacteria	P	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
CH3_k127_8327810_11	452637.Oter_3105	1.123e-37	146.0	COG2020@1|root,COG2020@2|Bacteria,46WMG@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CH3_k127_8327810_6	697282.Mettu_3066	1.506e-93	313.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria,1XEYK@135618|Methylococcales	135618|Methylococcales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CH3_k127_8327810_1	697282.Mettu_3067	3.044e-274	867.0	COG4262@1|root,COG4262@2|Bacteria,1QUPY@1224|Proteobacteria,1RMJV@1236|Gammaproteobacteria,1XFY9@135618|Methylococcales	135618|Methylococcales	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
CH3_k127_8327810_9	1116472.MGMO_45c00020	1.974e-45	171.0	2EJWJ@1|root,33DM8@2|Bacteria,1NNFZ@1224|Proteobacteria,1SHVK@1236|Gammaproteobacteria,1XFJC@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8327810_5	1116472.MGMO_136c00030	4.395e-122	394.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,1RPQV@1236|Gammaproteobacteria,1XEAM@135618|Methylococcales	135618|Methylococcales	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
CH3_k127_8327810_10	1089439.KB902271_gene2006	8.018e-45	165.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1S8U3@1236|Gammaproteobacteria,461G4@72273|Thiotrichales	72273|Thiotrichales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
CH3_k127_8327810_2	697282.Mettu_2001	1.972e-224	702.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1XECR@135618|Methylococcales	135618|Methylococcales	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CH3_k127_8327810_7	857087.Metme_1566	9.175e-71	245.0	COG3809@1|root,COG3809@2|Bacteria,1PA07@1224|Proteobacteria,1TI22@1236|Gammaproteobacteria,1XGBQ@135618|Methylococcales	135618|Methylococcales	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
CH3_k127_8327810_4	857087.Metme_1565	1.921e-143	462.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,1S1VS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	virion core protein (lumpy skin disease virus)	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1
CH3_k127_8327810_8	697282.Mettu_2916	3.606e-62	216.0	COG1569@1|root,COG1569@2|Bacteria,1N1T4@1224|Proteobacteria,1SE91@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	toxin-antitoxin system toxin component, PIN family	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
CH3_k127_8327810_12	697282.Mettu_2915	3.524e-31	123.0	COG4226@1|root,COG4226@2|Bacteria,1N9EG@1224|Proteobacteria,1SCXG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
CH3_k127_8327810_13	349124.Hhal_0688	6.011e-19	92.0	2AV75@1|root,31KXS@2|Bacteria,1RKU0@1224|Proteobacteria,1S7D1@1236|Gammaproteobacteria,1WYSC@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1640)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
CH3_k127_8327810_0	686340.Metal_3903	0.0	1494.0	COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,1XDTE@135618|Methylococcales	135618|Methylococcales	C	Belongs to the aconitase IPM isomerase family	-	-	4.2.1.3,4.2.1.99	ko:K01682	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173	R01324,R01325,R01900,R04425	RC00497,RC00498,RC00618,RC01153	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_2_N,Aconitase_B_N
CH3_k127_8327810_15	756067.MicvaDRAFT_2318	1.196e-15	87.0	COG1061@1|root,COG1061@2|Bacteria,1GCH4@1117|Cyanobacteria	1117|Cyanobacteria	L	Probable Zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4379,Methyltransf_8
CH3_k127_8341626_3	1116472.MGMO_74c00070	3.896e-110	359.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1XDUY@135618|Methylococcales	135618|Methylococcales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
CH3_k127_8341626_0	697282.Mettu_4274	1.451e-168	537.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1XEGW@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CH3_k127_8341626_2	857087.Metme_0310	1.151e-152	492.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1XEDR@135618|Methylococcales	135618|Methylococcales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CH3_k127_8341626_1	1123392.AQWL01000009_gene1070	1.329e-154	529.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS_4,PAS_7
CH3_k127_8341626_4	697282.Mettu_3857	1.694e-52	188.0	COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1XFCZ@135618|Methylococcales	135618|Methylococcales	P	DsrE/DsrF-like family	dsrE	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
CH3_k127_8341626_6	1116472.MGMO_37c00440	4.192e-23	104.0	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1XFPZ@135618|Methylococcales	135618|Methylococcales	P	Belongs to the DsrF TusC family	-	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
CH3_k127_8341626_5	1234364.AMSF01000025_gene3674	4.035e-33	132.0	COG0727@1|root,32S46@2|Bacteria,1MZCU@1224|Proteobacteria,1SCG7@1236|Gammaproteobacteria,1X7NC@135614|Xanthomonadales	135614|Xanthomonadales	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CH3_k127_8353378_1	63737.Npun_R1990	3.022e-64	227.0	COG0596@1|root,COG0596@2|Bacteria,1G0CB@1117|Cyanobacteria	1117|Cyanobacteria	S	Alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
CH3_k127_8353378_0	886293.Sinac_4323	1.597e-97	323.0	COG0604@1|root,COG0604@2|Bacteria,2J3EE@203682|Planctomycetes	203682|Planctomycetes	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CH3_k127_8485516_3	697282.Mettu_1416	2.218e-181	570.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,1RNEJ@1236|Gammaproteobacteria,1XDRX@135618|Methylococcales	135618|Methylococcales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
CH3_k127_8485516_2	1116472.MGMO_138c00420	5.757e-209	654.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1XDU5@135618|Methylococcales	135618|Methylococcales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	-	-	6.2.1.9	ko:K14067	ko00630,ko00680,ko01120,ko01200,map00630,map00680,map01120,map01200	M00346	R01256	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
CH3_k127_8485516_4	686340.Metal_1988	9.492e-167	526.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,1XGZC@135618|Methylococcales	135618|Methylococcales	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,Ligase_CoA
CH3_k127_8485516_0	857087.Metme_4450	0.0	1512.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XDXS@135618|Methylococcales	135618|Methylococcales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CH3_k127_8485516_5	697282.Mettu_0632	2.039e-165	531.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1XEAK@135618|Methylococcales	135618|Methylococcales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CH3_k127_8485516_1	697282.Mettu_0633	2.211e-255	793.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XEG9@135618|Methylococcales	135618|Methylococcales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
CH3_k127_8485516_9	211165.AJLN01000033_gene2689	3.499e-41	165.0	COG0584@1|root,COG0584@2|Bacteria,1G20Z@1117|Cyanobacteria	1117|Cyanobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CH3_k127_8485516_7	1123401.JHYQ01000046_gene2211	1.665e-60	214.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S3PW@1236|Gammaproteobacteria,460TT@72273|Thiotrichales	72273|Thiotrichales	M	Lipocalin-like domain	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
CH3_k127_8485516_8	1218084.BBJK01000118_gene6838	3.975e-55	204.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2W05D@28216|Betaproteobacteria,1KH5E@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome bd terminal oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
CH3_k127_8485516_6	697282.Mettu_2946	1.304e-158	512.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1XG6Z@135618|Methylococcales	135618|Methylococcales	C	Cytochrome bd terminal oxidase subunit I	-	-	-	-	-	-	-	-	-	-	-	-	Cyt_bd_oxida_I
CH3_k127_8485516_10	697282.Mettu_1213	2.139e-32	128.0	COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1T0WM@1236|Gammaproteobacteria,1XEZF@135618|Methylococcales	135618|Methylococcales	S	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF,PsiE
CH3_k127_8539264_0	857087.Metme_1830	6.761e-258	805.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1XGNR@135618|Methylococcales	135618|Methylococcales	P	PFAM Cation H exchanger	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
CH3_k127_8539264_1	1116472.MGMO_6c00030	4.365e-20	97.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,1XEQ1@135618|Methylococcales	135618|Methylococcales	S	Pfam:DUF490	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
CH3_k127_8652447_3	697282.Mettu_3579	1.611e-60	212.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XEZR@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosyl transferase domain	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CH3_k127_8652447_0	697282.Mettu_3578	8.128e-137	442.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1XEAX@135618|Methylococcales	135618|Methylococcales	M	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0008150,GO:0009273,GO:0009987,GO:0015929,GO:0016787,GO:0016798,GO:0042546,GO:0044085,GO:0071554,GO:0071840	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
CH3_k127_8652447_1	686340.Metal_3035	9.268e-105	346.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1XE5E@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
CH3_k127_8652447_4	697282.Mettu_3242	6.776e-57	205.0	2DS8R@1|root,33F1A@2|Bacteria,1MZBA@1224|Proteobacteria,1SBM3@1236|Gammaproteobacteria,1XFBX@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2380)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3280
CH3_k127_8652447_2	857087.Metme_1074	7.627e-93	305.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1XEMN@135618|Methylococcales	135618|Methylococcales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CH3_k127_8703529_5	697282.Mettu_2003	1.427e-33	130.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1XEIY@135618|Methylococcales	135618|Methylococcales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
CH3_k127_8703529_4	522306.CAP2UW1_1474	1.33e-45	171.0	COG0560@1|root,COG0560@2|Bacteria,1RKIX@1224|Proteobacteria,2VUZB@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CH3_k127_8703529_1	697282.Mettu_3599	2.445e-114	374.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1S5KU@1236|Gammaproteobacteria,1XDYF@135618|Methylococcales	135618|Methylococcales	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CH3_k127_8703529_2	706587.Desti_2056	1.149e-96	319.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
CH3_k127_8703529_0	686340.Metal_3537	3.98e-195	611.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,1RNFF@1236|Gammaproteobacteria,1XDSS@135618|Methylococcales	135618|Methylococcales	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	-	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
CH3_k127_8703529_3	697282.Mettu_3596	2.105e-47	174.0	COG4446@1|root,COG4446@2|Bacteria,1N7IZ@1224|Proteobacteria,1SCZH@1236|Gammaproteobacteria,1XFTQ@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
CH3_k127_8703529_6	990073.ATHU01000001_gene977	4.462e-09	68.0	COG0438@1|root,COG0438@2|Bacteria,1PFFG@1224|Proteobacteria,4349I@68525|delta/epsilon subdivisions,2YRPS@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CH3_k127_872036_6	794903.OPIT5_13260	0.0001502	50.0	2DEGC@1|root,2ZMWN@2|Bacteria	2|Bacteria	S	Membrane-bound lysozyme-inhibitor of c-type lysozyme	-	-	-	-	-	-	-	-	-	-	-	-	MliC
CH3_k127_872036_5	595460.RRSWK_01550	3.11e-15	89.0	COG3049@1|root,COG3049@2|Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
CH3_k127_872036_1	316067.Geob_1837	6.673e-35	136.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,42VQB@68525|delta/epsilon subdivisions,2WQFH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TIGRFAM addiction module antidote protein, HigA family	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
CH3_k127_872036_2	269796.Rru_A2020	1.909e-33	130.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,2UBQF@28211|Alphaproteobacteria,2JTS2@204441|Rhodospirillales	204441|Rhodospirillales	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
CH3_k127_872036_4	891968.Anamo_0242	1.481e-22	111.0	COG1014@1|root,COG1014@2|Bacteria,3TAX4@508458|Synergistetes	508458|Synergistetes	C	indolepyruvate ferredoxin oxidoreductase, beta subunit	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
CH3_k127_872036_0	1125863.JAFN01000001_gene1239	3.68e-70	243.0	COG0493@1|root,COG4231@1|root,COG0493@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-2	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
CH3_k127_8744393_1	697282.Mettu_2905	3.854e-68	241.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1XEWJ@135618|Methylococcales	135618|Methylococcales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T
CH3_k127_8744393_0	697282.Mettu_2903	2.106e-98	325.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria,1XDYN@135618|Methylococcales	135618|Methylococcales	O	Cytochrome oxidase assembly	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
CH3_k127_8745335_0	522306.CAP2UW1_1524	2.34e-308	957.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CH3_k127_8745335_1	56780.SYN_02946	2.929e-45	171.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
CH3_k127_8751180_0	595460.RRSWK_00757	1.344e-84	287.0	COG1305@1|root,COG1305@2|Bacteria,2IY1Q@203682|Planctomycetes	203682|Planctomycetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CH3_k127_8751180_2	1116472.MGMO_216c00030	4.679e-38	144.0	2CUP7@1|root,32SVQ@2|Bacteria,1QJVN@1224|Proteobacteria,1THXA@1236|Gammaproteobacteria,1XFY4@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8751180_1	686340.Metal_2986	7.549e-75	254.0	COG1541@1|root,COG1541@2|Bacteria,1R8T9@1224|Proteobacteria,1S1JC@1236|Gammaproteobacteria,1XEUW@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
CH3_k127_8782129_5	686340.Metal_3466	7.551e-31	123.0	COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1XE4Z@135618|Methylococcales	135618|Methylococcales	G	Belongs to the HAD-like hydrolase superfamily	-	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
CH3_k127_8782129_6	1116472.MGMO_14c00100	1.305e-30	125.0	COG1340@1|root,COG1340@2|Bacteria,1QVWN@1224|Proteobacteria,1T2KY@1236|Gammaproteobacteria,1XFSB@135618|Methylococcales	135618|Methylococcales	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
CH3_k127_8782129_0	697282.Mettu_3086	1.089e-261	813.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1XED7@135618|Methylococcales	135618|Methylococcales	HJ	PFAM ATP-grasp fold	-	-	-	-	-	-	-	-	-	-	-	-	RLAN,RimK
CH3_k127_8782129_2	697282.Mettu_3087	7.982e-150	482.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,1RZAW@1236|Gammaproteobacteria,1XE1U@135618|Methylococcales	135618|Methylococcales	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
CH3_k127_8782129_1	686340.Metal_3478	5.611e-166	533.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1XEX3@135618|Methylococcales	135618|Methylococcales	K	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,DUF3335
CH3_k127_8782129_4	196490.AUEZ01000005_gene3646	2.813e-31	127.0	COG2105@1|root,COG2105@2|Bacteria,1N80E@1224|Proteobacteria,2U5YU@28211|Alphaproteobacteria,3JY9V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
CH3_k127_8782129_3	686340.Metal_1802	1.504e-134	429.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,1RNAD@1236|Gammaproteobacteria,1XECQ@135618|Methylococcales	135618|Methylococcales	H	Sulfate adenylyltransferase subunit 2	cysD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004779,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
CH3_k127_8783447_2	697282.Mettu_3866	2.438e-30	122.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1XDXT@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CH3_k127_8783447_0	697282.Mettu_2135	0.0	1126.0	COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,1RP2H@1236|Gammaproteobacteria,1XEV9@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
CH3_k127_8783447_4	331113.SNE_A08720	2.064e-08	57.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2JGR0@204428|Chlamydiae	204428|Chlamydiae	H	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppsA	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CH3_k127_8783447_1	686340.Metal_1668	6.903e-52	187.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1XEDV@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CH3_k127_8783447_5	333138.LQ50_08950	5.441e-05	46.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,4HJ21@91061|Bacilli,1ZDSK@1386|Bacillus	91061|Bacilli	J	protein with SCP PR1 domains	ykwD	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM,SLH
CH3_k127_8846816_1	686340.Metal_2927	5.904e-77	265.0	2DBSQ@1|root,2ZATE@2|Bacteria,1N58C@1224|Proteobacteria,1SAPH@1236|Gammaproteobacteria,1XFMM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8846816_2	1116472.MGMO_44c00380	7.314e-74	252.0	COG2229@1|root,COG2229@2|Bacteria,1PYIA@1224|Proteobacteria,1S271@1236|Gammaproteobacteria,1XEEV@135618|Methylococcales	135618|Methylococcales	S	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
CH3_k127_8846816_0	697282.Mettu_3554	3.306e-236	741.0	COG1052@1|root,COG1052@2|Bacteria,1REXX@1224|Proteobacteria,1T2IU@1236|Gammaproteobacteria,1XEBK@135618|Methylococcales	135618|Methylococcales	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
CH3_k127_8846816_3	686340.Metal_2808	9.125e-66	229.0	COG0560@1|root,COG0560@2|Bacteria,1PIND@1224|Proteobacteria,1S9GK@1236|Gammaproteobacteria,1XEK5@135618|Methylococcales	135618|Methylococcales	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
CH3_k127_8872448_0	697282.Mettu_0814	0.0	1102.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1XEST@135618|Methylococcales	135618|Methylococcales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K01507,ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
CH3_k127_8872448_1	1123514.KB905900_gene2067	3.929e-114	375.0	COG2850@1|root,COG2850@2|Bacteria,1RDTN@1224|Proteobacteria,1SDPU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_8
CH3_k127_8877946_5	261292.Nit79A3_1676	3.331e-87	289.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VKXU@28216|Betaproteobacteria,371PX@32003|Nitrosomonadales	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CH3_k127_8877946_0	153948.NAL212_0541	0.0	1215.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria,371VR@32003|Nitrosomonadales	28216|Betaproteobacteria	P	von Willebrand factor, type A	norD	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
CH3_k127_8877946_2	153948.NAL212_0540	4.884e-170	535.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria,372X9@32003|Nitrosomonadales	28216|Betaproteobacteria	S	CbbQ/NirQ/NorQ C-terminal	norQ	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
CH3_k127_8877946_1	153948.NAL212_0539	1.277e-290	893.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2VHXU@28216|Betaproteobacteria,371TN@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cytochrome c oxidase, subunit I	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
CH3_k127_8877946_3	153948.NAL212_0538	4.789e-93	309.0	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,2VQ50@28216|Betaproteobacteria,37328@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cytochrome c	norC	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
CH3_k127_8877946_7	261292.Nit79A3_1675	9.719e-23	97.0	COG3746@1|root,COG3746@2|Bacteria,1RG6T@1224|Proteobacteria,2WBBI@28216|Betaproteobacteria,372S6@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
CH3_k127_8877946_6	261292.Nit79A3_1675	2.218e-42	155.0	COG3746@1|root,COG3746@2|Bacteria,1RG6T@1224|Proteobacteria,2WBBI@28216|Betaproteobacteria,372S6@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Phosphate-selective porin O and P	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
CH3_k127_8877946_4	261292.Nit79A3_1674	1.328e-90	299.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2WG5G@28216|Betaproteobacteria,373HV@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
CH3_k127_8895856_25	697282.Mettu_2454	2.599e-17	83.0	COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,1XFBI@135618|Methylococcales	135618|Methylococcales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
CH3_k127_8895856_27	697282.Mettu_2455	2.518e-14	75.0	2AUW6@1|root,31KJM@2|Bacteria,1QIEW@1224|Proteobacteria,1TG99@1236|Gammaproteobacteria,1XFWQ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8895856_2	686340.Metal_3723	1.95e-187	596.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1XEQ5@135618|Methylococcales	135618|Methylococcales	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
CH3_k127_8895856_20	697282.Mettu_2457	2.645e-60	214.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1XFCA@135618|Methylococcales	135618|Methylococcales	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
CH3_k127_8895856_12	697282.Mettu_2458	2.107e-114	377.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1XET8@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
CH3_k127_8895856_14	697282.Mettu_2459	1.807e-104	347.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1XDRR@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
CH3_k127_8895856_13	697282.Mettu_0486	2.016e-106	351.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1XEP4@135618|Methylococcales	135618|Methylococcales	M	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
CH3_k127_8895856_1	857087.Metme_4093	1.207e-190	601.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1XDYG@135618|Methylococcales	135618|Methylococcales	E	Aminotransferase, class I	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CH3_k127_8895856_7	1286106.MPL1_05057	1.614e-140	451.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,45ZN7@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
CH3_k127_8895856_21	686340.Metal_0757	7.078e-47	173.0	COG3160@1|root,COG3160@2|Bacteria,1QK4V@1224|Proteobacteria,1TI7Z@1236|Gammaproteobacteria,1XGQV@135618|Methylococcales	135618|Methylococcales	K	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ	-	-	-	-	-	-	-	-	-	-	-	-	Rsd_AlgQ
CH3_k127_8895856_0	697282.Mettu_2435	2.431e-225	707.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1XDUG@135618|Methylococcales	135618|Methylococcales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
CH3_k127_8895856_8	697282.Mettu_2436	7.645e-138	444.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1XDQQ@135618|Methylococcales	135618|Methylococcales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
CH3_k127_8895856_18	697282.Mettu_2437	2.224e-64	230.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1XEZI@135618|Methylococcales	135618|Methylococcales	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
CH3_k127_8895856_9	697282.Mettu_2438	3.956e-129	424.0	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RV2A@1236|Gammaproteobacteria,1XE6W@135618|Methylococcales	135618|Methylococcales	H	HemX, putative uroporphyrinogen-III C-methyltransferase	-	-	2.1.1.107,4.2.1.75	ko:K02496,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HemX
CH3_k127_8895856_5	697282.Mettu_2439	3.794e-163	522.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1XEHQ@135618|Methylococcales	135618|Methylococcales	H	HemY protein N-terminus	-	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_8
CH3_k127_8895856_24	697282.Mettu_0659	2.987e-25	106.0	2E7PS@1|root,3325B@2|Bacteria,1QNSP@1224|Proteobacteria,1SI7D@1236|Gammaproteobacteria,1XFUH@135618|Methylococcales	135618|Methylococcales	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_8895856_11	697282.Mettu_0647	5.295e-115	376.0	COG1985@1|root,COG1985@2|Bacteria,1RDMT@1224|Proteobacteria,1S4SQ@1236|Gammaproteobacteria,1XDKN@135618|Methylococcales	135618|Methylococcales	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
CH3_k127_8895856_26	857087.Metme_1357	2.414e-14	75.0	COG2879@1|root,COG2879@2|Bacteria,1PJJ4@1224|Proteobacteria,1SW5W@1236|Gammaproteobacteria,1XFXC@135618|Methylococcales	135618|Methylococcales	S	Selenoprotein, putative	-	-	-	-	-	-	-	-	-	-	-	-	Sel_put
CH3_k127_8895856_3	686340.Metal_1201	5.267e-184	586.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1XERM@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM dihydroorotase, multifunctional complex type	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CH3_k127_8895856_4	697282.Mettu_1596	1.635e-163	520.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1XE5I@135618|Methylococcales	135618|Methylococcales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CH3_k127_8895856_16	697282.Mettu_1597	9.47e-81	272.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1XF50@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosyl transferase domain	-	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
CH3_k127_8895856_19	697282.Mettu_1598	3.834e-63	220.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1XF42@135618|Methylococcales	135618|Methylococcales	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
CH3_k127_8895856_17	686340.Metal_1197	7.113e-77	261.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1XEAF@135618|Methylococcales	135618|Methylococcales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
CH3_k127_8895856_15	697282.Mettu_1600	2.244e-93	316.0	COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,1XDIM@135618|Methylococcales	135618|Methylococcales	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
CH3_k127_8895856_6	686340.Metal_1195	8.423e-163	520.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1XDKV@135618|Methylococcales	135618|Methylococcales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
CH3_k127_8895856_10	857087.Metme_1517	3.255e-116	380.0	COG0834@1|root,COG0834@2|Bacteria,1MWWZ@1224|Proteobacteria,1S2ZV@1236|Gammaproteobacteria,1XDTB@135618|Methylococcales	135618|Methylococcales	ET	ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
CH3_k127_8895856_22	1116472.MGMO_101c00100	7.998e-42	158.0	2C9B9@1|root,32RP0@2|Bacteria,1MZKM@1224|Proteobacteria,1S8UZ@1236|Gammaproteobacteria,1XFFN@135618|Methylococcales	135618|Methylococcales	S	PFAM HopJ type III effector protein	-	-	-	-	-	-	-	-	-	-	-	-	HopJ
CH3_k127_8895856_23	1116472.MGMO_100c00110	7.32e-40	151.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1XDK9@135618|Methylococcales	135618|Methylococcales	L	TIGRFAM RNA helicase, ATP-dependent DEAH box, HrpA type	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DUF3418,HA2,Helicase_C,OB_NTP_bind
CH3_k127_8901049_2	1517416.IDAT_02075	3.267e-31	124.0	COG2161@1|root,COG2161@2|Bacteria,1N07B@1224|Proteobacteria,1S90V@1236|Gammaproteobacteria,2QGYZ@267893|Idiomarinaceae	1236|Gammaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CH3_k127_8901049_1	857087.Metme_3841	4.269e-139	448.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1XFRX@135618|Methylococcales	135618|Methylococcales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
CH3_k127_8901049_0	697282.Mettu_1027	5.049e-225	713.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1XEUV@135618|Methylococcales	135618|Methylococcales	H	TonB dependent receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
CH3_k127_8942495_1	697282.Mettu_2467	1.262e-67	244.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1XDVI@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
CH3_k127_8942495_0	686340.Metal_1439	2.333e-261	810.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1XE4S@135618|Methylococcales	135618|Methylococcales	J	ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
CH3_k127_8977383_7	177439.DP0689	1.104e-06	50.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
CH3_k127_8977383_1	697282.Mettu_0336	5.599e-271	846.0	COG1368@1|root,COG1368@2|Bacteria,1RG6W@1224|Proteobacteria,1RY34@1236|Gammaproteobacteria,1XFZX@135618|Methylococcales	135618|Methylococcales	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CH3_k127_8977383_0	697282.Mettu_0414	0.0	1197.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1XEQR@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
CH3_k127_8977383_3	697282.Mettu_0415	7.947e-249	772.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1XEBP@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CH3_k127_8977383_4	1116472.MGMO_152c00080	6.535e-191	609.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1XDQU@135618|Methylococcales	135618|Methylococcales	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
CH3_k127_8977383_2	857087.Metme_2910	7.646e-264	826.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1XEA6@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
CH3_k127_8977383_5	857087.Metme_2911	1.13e-87	295.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1S11C@1236|Gammaproteobacteria,1XE7W@135618|Methylococcales	135618|Methylococcales	G	6-phosphogluconolactonase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
CH3_k127_8977383_6	472759.Nhal_2543	1.73e-24	104.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
CH3_k127_9026071_4	1116472.MGMO_45c00110	5.546e-81	270.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XE7N@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CH3_k127_9026071_3	686340.Metal_3464	3.944e-91	303.0	COG0794@1|root,COG0794@2|Bacteria,1RFKB@1224|Proteobacteria,1S5NP@1236|Gammaproteobacteria,1XEGT@135618|Methylococcales	135618|Methylococcales	M	SIS domain	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
CH3_k127_9026071_2	857087.Metme_0742	2.381e-112	365.0	COG0269@1|root,COG0269@2|Bacteria,1QWE4@1224|Proteobacteria,1RRCI@1236|Gammaproteobacteria,1XEF9@135618|Methylococcales	135618|Methylococcales	G	PFAM Orotidine 5'-phosphate decarboxylase	-	-	4.1.2.43	ko:K08093	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338	RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
CH3_k127_9026071_6	686340.Metal_3540	5.827e-29	119.0	2EGR8@1|root,33AHD@2|Bacteria,1N6Z8@1224|Proteobacteria,1SDY4@1236|Gammaproteobacteria,1XFNZ@135618|Methylococcales	135618|Methylococcales	S	FeoC like transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FeoC
CH3_k127_9026071_1	697282.Mettu_1008	0.0	1130.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1XENN@135618|Methylococcales	135618|Methylococcales	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
CH3_k127_9026071_5	686340.Metal_3538	3.507e-30	121.0	COG1918@1|root,COG1918@2|Bacteria,1N8ZJ@1224|Proteobacteria,1S9TZ@1236|Gammaproteobacteria,1XFKX@135618|Methylococcales	135618|Methylococcales	P	PFAM Ferrous iron transporter, FeoA subunit	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
CH3_k127_9026071_0	686340.Metal_2868	0.0	1502.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1XEBW@135618|Methylococcales	135618|Methylococcales	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
CH3_k127_9069941_0	1116472.MGMO_124c00230	1.447e-114	381.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1XES6@135618|Methylococcales	135618|Methylococcales	K	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
CH3_k127_9069941_3	715451.ambt_18080	2.013e-16	83.0	2EHHF@1|root,33B9C@2|Bacteria,1NM2H@1224|Proteobacteria,1SGI5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9069941_2	1116472.MGMO_7c00370	1.465e-27	117.0	29V41@1|root,30GHG@2|Bacteria,1QJT6@1224|Proteobacteria,1THUE@1236|Gammaproteobacteria,1XFRB@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9069941_1	697282.Mettu_1865	1.796e-85	285.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,1XEDN@135618|Methylococcales	135618|Methylococcales	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
CH3_k127_9100531_3	1007105.PT7_P073	7.349e-26	109.0	2CH99@1|root,32S5M@2|Bacteria,1N2GH@1224|Proteobacteria,2W6BX@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Recombination enhancement, RecA-dependent nuclease	-	-	-	-	-	-	-	-	-	-	-	-	RecA_dep_nuc
CH3_k127_9100531_4	1007105.PT7_P074	9.844e-26	120.0	2C58H@1|root,32YYI@2|Bacteria,1N7UA@1224|Proteobacteria,2VYT7@28216|Betaproteobacteria,3T4RW@506|Alcaligenaceae	28216|Betaproteobacteria	S	NinB protein	-	-	-	-	-	-	-	-	-	-	-	-	NinB
CH3_k127_9100531_1	398578.Daci_1624	4.276e-57	209.0	COG4643@1|root,COG4643@2|Bacteria,1QTXN@1224|Proteobacteria,2VM6N@28216|Betaproteobacteria,4AFNF@80864|Comamonadaceae	28216|Betaproteobacteria	S	Primase C terminal 2 (PriCT-2)	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	AAA_25,PriCT_2,Toprim_3,Toprim_4
CH3_k127_9100531_0	398578.Daci_1623	5.861e-80	295.0	COG1061@1|root,COG1061@2|Bacteria,1MV9F@1224|Proteobacteria,2VQF3@28216|Betaproteobacteria,4ADUP@80864|Comamonadaceae	28216|Betaproteobacteria	L	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII,UPF0547
CH3_k127_9100531_2	697282.Mettu_3495	9.973e-40	158.0	COG1475@1|root,COG1475@2|Bacteria,1NBHA@1224|Proteobacteria	1224|Proteobacteria	K	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9110635_3	686340.Metal_3043	1.486e-11	68.0	COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1XEUD@135618|Methylococcales	135618|Methylococcales	L	Exonuclease C-terminal	sbcB	-	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
CH3_k127_9110635_1	697282.Mettu_1413	5.27e-228	712.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1XEE1@135618|Methylococcales	135618|Methylococcales	C	TrkA-C domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CH3_k127_9110635_0	857087.Metme_4157	3.207e-277	864.0	COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RRZM@1236|Gammaproteobacteria,1XH02@135618|Methylococcales	135618|Methylococcales	C	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,SCO1-SenC
CH3_k127_9110635_2	857087.Metme_4384	7.818e-150	476.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,1S012@1236|Gammaproteobacteria,1XDJS@135618|Methylococcales	135618|Methylococcales	S	56kDa selenium binding protein (SBP56)	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
CH3_k127_9118587_0	1038862.KB893843_gene453	1.451e-286	919.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
CH3_k127_9118587_3	686340.Metal_1556	2.46e-45	166.0	COG1942@1|root,COG1942@2|Bacteria,1N1GC@1224|Proteobacteria,1SB41@1236|Gammaproteobacteria,1XFD8@135618|Methylococcales	135618|Methylococcales	S	Macrophage migration inhibitory factor	-	-	-	-	-	-	-	-	-	-	-	-	MIF
CH3_k127_9118587_2	1283300.ATXB01000001_gene2264	1.265e-93	313.0	COG1893@1|root,COG1893@2|Bacteria,1R60C@1224|Proteobacteria,1RZQZ@1236|Gammaproteobacteria,1XGCN@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9118587_1	697282.Mettu_2562	4.259e-146	476.0	COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,1RR20@1236|Gammaproteobacteria,1XETQ@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3422)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
CH3_k127_9118587_4	1116472.MGMO_107c00100	3.253e-09	59.0	28IA9@1|root,2Z9M7@2|Bacteria,1QTVI@1224|Proteobacteria,1T1IN@1236|Gammaproteobacteria,1XEN0@135618|Methylococcales	135618|Methylococcales	S	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
CH3_k127_912268_1	697282.Mettu_3528	1.441e-248	774.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,1T1PS@1236|Gammaproteobacteria,1XEC5@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CH3_k127_912268_6	1116472.MGMO_66c00010	7.223e-124	398.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1S4C2@1236|Gammaproteobacteria,1XEDC@135618|Methylococcales	135618|Methylococcales	K	SMART Signal transduction response regulator, receiver region	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CH3_k127_912268_17	1122212.AULO01000014_gene1157	7.1e-56	207.0	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,1RYIU@1236|Gammaproteobacteria,1XKCX@135619|Oceanospirillales	135619|Oceanospirillales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
CH3_k127_912268_13	686340.Metal_2646	6.849e-93	310.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1XE36@135618|Methylococcales	135618|Methylococcales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CH3_k127_912268_7	697282.Mettu_2588	1.902e-121	394.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1XEAN@135618|Methylococcales	135618|Methylococcales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
CH3_k127_912268_15	697282.Mettu_2587	1.592e-67	234.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1SASJ@1236|Gammaproteobacteria,1XF6Y@135618|Methylococcales	135618|Methylococcales	S	PFAM Smr	-	-	-	-	-	-	-	-	-	-	-	-	Smr
CH3_k127_912268_5	686340.Metal_2649	5.585e-127	415.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1XDYC@135618|Methylococcales	135618|Methylococcales	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
CH3_k127_912268_14	1116472.MGMO_55c00210	4.397e-70	245.0	COG0850@1|root,COG0850@2|Bacteria,1RHVN@1224|Proteobacteria,1S6K8@1236|Gammaproteobacteria,1XEV4@135618|Methylococcales	135618|Methylococcales	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization	minC	-	-	ko:K03610	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinC_C,MinC_N
CH3_k127_912268_3	857087.Metme_0712	4.25e-151	480.0	COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,1RNJ0@1236|Gammaproteobacteria,1XEDI@135618|Methylococcales	135618|Methylococcales	D	Belongs to the ParA family	minD	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
CH3_k127_912268_19	261292.Nit79A3_3451	7.045e-34	135.0	COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,2VTX1@28216|Betaproteobacteria,373AH@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell	minE	-	-	ko:K03608	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinE
CH3_k127_912268_22	697282.Mettu_2486	1.932e-20	92.0	2BGZ0@1|root,32AZ4@2|Bacteria,1P5WT@1224|Proteobacteria,1ST5B@1236|Gammaproteobacteria,1XFQW@135618|Methylococcales	135618|Methylococcales	S	Winged helix-turn-helix domain (DUF2582)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2582
CH3_k127_912268_2	472759.Nhal_0326	2.33e-163	525.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1WW0B@135613|Chromatiales	135613|Chromatiales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
CH3_k127_912268_21	857087.Metme_3343	1.59e-27	116.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1XF61@135618|Methylococcales	135618|Methylococcales	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
CH3_k127_912268_11	697282.Mettu_1914	1.341e-99	328.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1XDNH@135618|Methylococcales	135618|Methylococcales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CH3_k127_912268_4	1116472.MGMO_11c00620	1.672e-139	447.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1XDX3@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
CH3_k127_912268_16	686340.Metal_0165	1.137e-63	234.0	COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1XEQC@135618|Methylococcales	135618|Methylococcales	S	Putative DNA-binding domain	-	-	-	ko:K09929	-	-	-	-	ko00000	-	-	-	DUF2063
CH3_k127_912268_20	1279017.AQYJ01000024_gene980	9.087e-33	129.0	COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,467KQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1820)	IV02_29925	-	-	-	-	-	-	-	-	-	-	-	DUF1820
CH3_k127_912268_18	697282.Mettu_0171	1.353e-54	194.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1XFC6@135618|Methylococcales	135618|Methylococcales	S	PFAM Stringent starvation protein B	sspB	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
CH3_k127_912268_9	697282.Mettu_0172	1.247e-101	334.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1XDPJ@135618|Methylococcales	135618|Methylococcales	O	PFAM Glutathione S-transferase, N-terminal	sspA	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_N_3
CH3_k127_912268_10	857087.Metme_0674	1.08e-100	333.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1XE3J@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
CH3_k127_912268_0	857087.Metme_0675	1.036e-251	783.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1XECN@135618|Methylococcales	135618|Methylococcales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
CH3_k127_912268_12	697282.Mettu_0175	1.999e-97	322.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1XE9E@135618|Methylococcales	135618|Methylococcales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
CH3_k127_912268_8	686340.Metal_0300	2.099e-107	354.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1XEPR@135618|Methylococcales	135618|Methylococcales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CH3_k127_9135593_5	857087.Metme_0928	3.968e-69	242.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1XDXC@135618|Methylococcales	135618|Methylococcales	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
CH3_k127_9135593_0	697282.Mettu_4262	5.411e-243	779.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1XETE@135618|Methylococcales	135618|Methylococcales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
CH3_k127_9135593_2	686340.Metal_2633	3.345e-123	405.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1XDY9@135618|Methylococcales	135618|Methylococcales	S	Phosphotransferase enzyme family	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
CH3_k127_9135593_4	686340.Metal_2632	1.909e-83	285.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1XE24@135618|Methylococcales	135618|Methylococcales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
CH3_k127_9135593_7	697282.Mettu_4265	1.967e-30	123.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1SCF7@1236|Gammaproteobacteria,1XFQV@135618|Methylococcales	135618|Methylococcales	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
CH3_k127_9135593_1	697282.Mettu_3575	2.105e-124	409.0	2B1NE@1|root,31U3X@2|Bacteria,1QJJ9@1224|Proteobacteria,1THJK@1236|Gammaproteobacteria,1XEJ9@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9135593_6	697282.Mettu_3576	3.75e-57	203.0	COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1XFA7@135618|Methylococcales	135618|Methylococcales	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT
CH3_k127_9135593_3	857087.Metme_2293	1.141e-102	341.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1XDU4@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.44	ko:K19696	ko00270,ko01100,map00270,map01100	-	R09668	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CH3_k127_9135593_8	697282.Mettu_3579	3.779e-10	60.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XEZR@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosyl transferase domain	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CH3_k127_9135652_0	697282.Mettu_2550	2.501e-135	434.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1XDUK@135618|Methylococcales	135618|Methylococcales	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
CH3_k127_9135652_1	754476.Q7A_561	1.536e-86	289.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,45ZW8@72273|Thiotrichales	72273|Thiotrichales	O	Alkyl hydroperoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CH3_k127_9141432_0	857087.Metme_1829	3.734e-223	704.0	28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,1XG5I@135618|Methylococcales	135618|Methylococcales	M	Fatty acid cis/trans isomerase (CTI)	-	-	-	-	-	-	-	-	-	-	-	-	CTI
CH3_k127_9141432_1	697282.Mettu_1903	1.569e-82	277.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XE7K@135618|Methylococcales	135618|Methylococcales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
CH3_k127_9151798_3	697282.Mettu_3879	5.484e-37	147.0	COG2218@1|root,COG2218@2|Bacteria,1MUUQ@1224|Proteobacteria,1S19G@1236|Gammaproteobacteria,1XEVQ@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM formylmethanofuran dehydrogenase subunit C	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
CH3_k127_9151798_0	686340.Metal_0412	7.23e-173	544.0	COG2037@1|root,COG2037@2|Bacteria,1MVSD@1224|Proteobacteria,1SKSG@1236|Gammaproteobacteria,1XE1H@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)	ffsA	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
CH3_k127_9151798_1	686340.Metal_0407	1.994e-43	160.0	2DQ4M@1|root,334QD@2|Bacteria,1NC4H@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CH3_k127_9151798_7	555779.Dthio_PD0170	2.88e-06	49.0	2E3EN@1|root,32YDN@2|Bacteria,1N7N7@1224|Proteobacteria,42VC8@68525|delta/epsilon subdivisions,2WS7K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
CH3_k127_9151798_4	111780.Sta7437_1085	1.75e-32	128.0	COG1724@1|root,COG1724@2|Bacteria,1G85S@1117|Cyanobacteria,3VKKV@52604|Pleurocapsales	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CH3_k127_9151798_5	56107.Cylst_0237	7.657e-24	102.0	COG1598@1|root,COG1598@2|Bacteria,1GA36@1117|Cyanobacteria,1HQCD@1161|Nostocales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	DUF1902
CH3_k127_9151798_6	1116472.MGMO_40c00020	1.324e-11	64.0	COG1229@1|root,COG1229@2|Bacteria,1NX13@1224|Proteobacteria,1RZ5G@1236|Gammaproteobacteria,1XDSE@135618|Methylococcales	135618|Methylococcales	C	TIGRFAM Formylmethanofuran dehydrogenase, subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
CH3_k127_9154573_1	1116472.MGMO_27c00290	3.69e-170	546.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,1XDYA@135618|Methylococcales	135618|Methylococcales	Q	Flavin containing amine oxidoreductase	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
CH3_k127_9154573_6	686340.Metal_3253	2.32e-52	189.0	COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,1S9AV@1236|Gammaproteobacteria,1XFI6@135618|Methylococcales	135618|Methylococcales	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
CH3_k127_9154573_2	697282.Mettu_1657	1.315e-126	413.0	COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,1RMNN@1236|Gammaproteobacteria,1XE1M@135618|Methylococcales	135618|Methylococcales	L	May be involved in recombination	rdgC	-	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
CH3_k127_9154573_3	1116472.MGMO_92c00430	5.697e-106	354.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XE3K@135618|Methylococcales	135618|Methylococcales	M	PFAM YkuD domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
CH3_k127_9154573_7	697282.Mettu_1555	2.003e-22	99.0	2EFUG@1|root,339KM@2|Bacteria,1NGQQ@1224|Proteobacteria,1SHZI@1236|Gammaproteobacteria,1XFQZ@135618|Methylococcales	135618|Methylococcales	S	Alanine-zipper, major outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Alanine_zipper
CH3_k127_9154573_5	1116472.MGMO_105c00280	8.657e-65	226.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S8WW@1236|Gammaproteobacteria,1XEZJ@135618|Methylococcales	135618|Methylococcales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
CH3_k127_9154573_0	686340.Metal_3257	7.997e-281	870.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria,1XEJK@135618|Methylococcales	135618|Methylococcales	G	alpha beta alpha domain I	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CH3_k127_9154573_4	697282.Mettu_1558	3.444e-104	342.0	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,1RRYS@1236|Gammaproteobacteria,1XDSY@135618|Methylococcales	135618|Methylococcales	P	ZIP Zinc transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_916801_11	1116472.MGMO_49c00070	2.038e-05	50.0	2AUT7@1|root,31KG9@2|Bacteria,1QIBC@1224|Proteobacteria,1TG5J@1236|Gammaproteobacteria,1XFQS@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_916801_0	1123508.JH636445_gene6575	0.0	1397.0	COG3696@1|root,COG3696@2|Bacteria,2J1ZR@203682|Planctomycetes	203682|Planctomycetes	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
CH3_k127_916801_5	1123508.JH636445_gene6574	7.085e-94	322.0	COG0845@1|root,COG0845@2|Bacteria,2J214@203682|Planctomycetes	203682|Planctomycetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
CH3_k127_916801_3	686340.Metal_1480	1.042e-107	366.0	COG1538@1|root,COG1538@2|Bacteria,1QITP@1224|Proteobacteria,1TGP9@1236|Gammaproteobacteria,1XG42@135618|Methylococcales	135618|Methylococcales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CH3_k127_916801_8	1519464.HY22_11255	9.355e-65	231.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	-	-	-	ko:K02471,ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.203.11,3.A.1.203.4,3.A.1.21	-	-	ABC_membrane,ABC_tran
CH3_k127_916801_10	502025.Hoch_5330	7.215e-15	88.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria,2YUCY@29|Myxococcales	28221|Deltaproteobacteria	O	PFAM peptidase S8 and S53 subtilisin kexin sedolisin	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,Peptidase_S8
CH3_k127_916801_7	697282.Mettu_0226	4.583e-71	247.0	COG0398@1|root,COG0398@2|Bacteria,1QJNQ@1224|Proteobacteria,1THPM@1236|Gammaproteobacteria,1XF7E@135618|Methylococcales	135618|Methylococcales	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CH3_k127_916801_4	580332.Slit_0299	6.216e-102	338.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VQEJ@28216|Betaproteobacteria,44WFQ@713636|Nitrosomonadales	28216|Betaproteobacteria	KT	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
CH3_k127_916801_1	743299.Acife_0694	3.056e-256	796.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,2NBW1@225057|Acidithiobacillales	1236|Gammaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
CH3_k127_916801_9	240292.Ava_C0152	4.354e-20	94.0	COG1023@1|root,COG1023@2|Bacteria,1G07T@1117|Cyanobacteria,1HRB5@1161|Nostocales	1117|Cyanobacteria	C	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
CH3_k127_916801_6	1005048.CFU_1722	1.034e-82	280.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,2WH34@28216|Betaproteobacteria	28216|Betaproteobacteria	G	6-phosphogluconate dehydrogenase	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
CH3_k127_916801_2	697282.Mettu_0654	1.356e-120	390.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1XG7M@135618|Methylococcales	135618|Methylococcales	C	Aconitase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
CH3_k127_9178881_2	322710.Avin_40760	1.878e-140	455.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
CH3_k127_9178881_0	697282.Mettu_1694	3.755e-181	572.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1XE9T@135618|Methylococcales	135618|Methylococcales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
CH3_k127_9178881_4	371042.NG99_07665	9.322e-40	148.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,3X6NU@551|Erwinia	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
CH3_k127_9178881_3	697282.Mettu_1696	7.811e-48	173.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1XFB6@135618|Methylococcales	135618|Methylococcales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
CH3_k127_9178881_1	697282.Mettu_1697	4.339e-162	516.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1XECC@135618|Methylococcales	135618|Methylococcales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
CH3_k127_9178881_5	1283300.ATXB01000002_gene2557	5.882e-37	141.0	COG4974@1|root,COG4974@2|Bacteria,1QV9T@1224|Proteobacteria,1T2UQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
CH3_k127_9178881_6	1419583.V466_29155	1.507e-12	74.0	COG2932@1|root,COG2932@2|Bacteria,1PIRG@1224|Proteobacteria,1S499@1236|Gammaproteobacteria,1YNAW@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Transcriptional regulator	prtR_1	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_S24
CH3_k127_9270236_4	1283300.ATXB01000001_gene335	2.131e-57	207.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1XDIX@135618|Methylococcales	135618|Methylococcales	E	PFAM Bacterial extracellular solute-binding	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
CH3_k127_9270236_1	686340.Metal_0528	4.14e-135	434.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1XDVR@135618|Methylococcales	135618|Methylococcales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CH3_k127_9270236_0	697282.Mettu_1021	1.038e-208	655.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1XEVP@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CH3_k127_9270236_3	857087.Metme_1613	3.966e-71	245.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1XF1C@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CH3_k127_9270236_5	857087.Metme_1614	1.088e-37	145.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1XFDN@135618|Methylococcales	135618|Methylococcales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
CH3_k127_9270236_6	857087.Metme_0482	1.959e-34	136.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1S9P2@1236|Gammaproteobacteria,1XGYG@135618|Methylococcales	135618|Methylococcales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
CH3_k127_9270236_2	697282.Mettu_1042	1.672e-123	399.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1XEGN@135618|Methylococcales	135618|Methylococcales	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CH3_k127_928969_15	1116472.MGMO_88c00380	6.933e-16	77.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1XE54@135618|Methylococcales	135618|Methylococcales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CH3_k127_928969_12	232348.ADXL01000091_gene464	2.541e-28	118.0	COG3577@1|root,COG3577@2|Bacteria,1G6TW@1117|Cyanobacteria	1117|Cyanobacteria	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	gag-asp_proteas
CH3_k127_928969_2	857087.Metme_3297	1.472e-197	621.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1XERV@135618|Methylococcales	135618|Methylococcales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
CH3_k127_928969_0	697282.Mettu_0314	0.0	1101.0	COG0744@1|root,COG0768@1|root,COG0744@2|Bacteria,COG0768@2|Bacteria,1NRPB@1224|Proteobacteria,1RNG3@1236|Gammaproteobacteria,1XEBS@135618|Methylococcales	135618|Methylococcales	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly
CH3_k127_928969_11	857087.Metme_3498	1.807e-33	134.0	2939Q@1|root,2ZQSH@2|Bacteria,1P5RJ@1224|Proteobacteria,1SVBP@1236|Gammaproteobacteria,1XFHZ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_928969_3	697282.Mettu_0123	4.833e-166	537.0	2A8Z1@1|root,32CQ3@2|Bacteria,1QJGZ@1224|Proteobacteria,1THGT@1236|Gammaproteobacteria,1XDVK@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_928969_7	314345.SPV1_14264	4.059e-114	375.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria	1224|Proteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CH3_k127_928969_6	697282.Mettu_0122	1.089e-137	441.0	COG0842@1|root,COG0842@2|Bacteria,1MVUG@1224|Proteobacteria,1RNF7@1236|Gammaproteobacteria,1XDP2@135618|Methylococcales	135618|Methylococcales	V	TIGRFAM alcohol ABC transporter, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CH3_k127_928969_8	1116472.MGMO_44c00220	1.304e-103	343.0	COG1131@1|root,COG1131@2|Bacteria,1MX56@1224|Proteobacteria,1S0C7@1236|Gammaproteobacteria,1XDVN@135618|Methylococcales	135618|Methylococcales	V	TIGRFAM ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_928969_4	697282.Mettu_0120	1.918e-150	481.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,1RQZK@1236|Gammaproteobacteria,1XDUS@135618|Methylococcales	135618|Methylococcales	S	TIGRFAM PQQ-dependent catabolism-associated beta-propeller protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
CH3_k127_928969_5	697282.Mettu_0119	1.875e-139	454.0	COG0683@1|root,COG0683@2|Bacteria,1MWGW@1224|Proteobacteria,1RQ5G@1236|Gammaproteobacteria,1XDS8@135618|Methylococcales	135618|Methylococcales	E	TIGRFAM ABC transporter, substrate binding protein, PQQ-dependent alcohol dehydrogenase system	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
CH3_k127_928969_18	857087.Metme_2949	8.473e-11	64.0	2EKAZ@1|root,2ZI7M@2|Bacteria,1P6J4@1224|Proteobacteria,1SVHE@1236|Gammaproteobacteria,1XFVN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_928969_16	857087.Metme_2948	1.036e-15	78.0	2BKZK@1|root,32FGB@2|Bacteria,1Q0KS@1224|Proteobacteria,1THWE@1236|Gammaproteobacteria,1XFVS@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ATPase-cat_bd
CH3_k127_928969_14	686340.Metal_0794	4.927e-18	89.0	2EIVN@1|root,33CM0@2|Bacteria,1NP3M@1224|Proteobacteria,1SVDM@1236|Gammaproteobacteria,1XFTE@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_928969_17	686340.Metal_0795	2.895e-15	83.0	2E75F@1|root,331PN@2|Bacteria,1N33G@1224|Proteobacteria,1SQ3F@1236|Gammaproteobacteria,1XFKV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_928969_13	686340.Metal_0795	1.617e-25	107.0	2E75F@1|root,331PN@2|Bacteria,1N33G@1224|Proteobacteria,1SQ3F@1236|Gammaproteobacteria,1XFKV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_928969_1	857087.Metme_2945	5.389e-310	972.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XE6F@135618|Methylococcales	135618|Methylococcales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CH3_k127_928969_9	857087.Metme_2944	2.443e-71	248.0	COG2836@1|root,COG2836@2|Bacteria,1R9GA@1224|Proteobacteria,1THXJ@1236|Gammaproteobacteria,1XFZ7@135618|Methylococcales	135618|Methylococcales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
CH3_k127_928969_10	686340.Metal_0870	3.735e-53	192.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1XFH8@135618|Methylococcales	135618|Methylococcales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
CH3_k127_9291346_3	56780.SYN_02946	6.677e-93	315.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
CH3_k127_9291346_2	857087.Metme_2380	3.081e-131	423.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1XESD@135618|Methylococcales	135618|Methylococcales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
CH3_k127_9291346_4	686340.Metal_3130	1.42e-76	258.0	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,1S6DY@1236|Gammaproteobacteria,1XF6M@135618|Methylococcales	135618|Methylococcales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
CH3_k127_9291346_0	686340.Metal_3129	2.44e-181	580.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1XDWN@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
CH3_k127_9291346_5	697282.Mettu_0882	4.274e-68	236.0	COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria,1XEZY@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
CH3_k127_9291346_1	697282.Mettu_0848	8.939e-143	472.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,1XDS4@135618|Methylococcales	135618|Methylococcales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_929681_3	1082933.MEA186_08029	1.188e-25	118.0	2DPY8@1|root,333WS@2|Bacteria,1R3GP@1224|Proteobacteria,2U02R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
CH3_k127_929681_1	1079460.ATTQ01000009_gene683	1.451e-43	171.0	COG3267@1|root,COG3267@2|Bacteria,1MYKB@1224|Proteobacteria,2UPHB@28211|Alphaproteobacteria,4BEIV@82115|Rhizobiaceae	28211|Alphaproteobacteria	U	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
CH3_k127_929681_0	697282.Mettu_3948	1.988e-75	256.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,1XF2Q@135618|Methylococcales	135618|Methylococcales	E	PFAM Haloacid dehalogenase-like hydrolase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
CH3_k127_929681_2	1286106.MPL1_09255	1.825e-28	120.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,460NX@72273|Thiotrichales	72273|Thiotrichales	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CH3_k127_9334477_0	686340.Metal_2419	6.246e-319	990.0	2C5N3@1|root,33WN9@2|Bacteria,1NWX1@1224|Proteobacteria,1THG7@1236|Gammaproteobacteria,1XDR1@135618|Methylococcales	135618|Methylococcales	S	Zeta toxin	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
CH3_k127_9334477_1	686340.Metal_1410	2.203e-288	894.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XDV1@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
CH3_k127_9334477_2	857087.Metme_1304	3.194e-93	310.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1XF71@135618|Methylococcales	135618|Methylococcales	K	transcriptional regulator, Crp	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CH3_k127_9350662_5	697282.Mettu_3166	1.636e-65	230.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XEG1@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
CH3_k127_9350662_6	697282.Mettu_3167	3.65e-37	152.0	COG3317@1|root,COG3317@2|Bacteria,1QJPQ@1224|Proteobacteria,1THQN@1236|Gammaproteobacteria,1XFC9@135618|Methylococcales	135618|Methylococcales	M	NlpB/DapX lipoprotein	-	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
CH3_k127_9350662_2	697282.Mettu_3168	6.735e-151	486.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1XDWP@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CH3_k127_9350662_1	686340.Metal_3152	3.051e-193	608.0	COG0269@1|root,COG0794@1|root,COG0269@2|Bacteria,COG0794@2|Bacteria,1QWE4@1224|Proteobacteria,1RPV5@1236|Gammaproteobacteria,1XDWM@135618|Methylococcales	135618|Methylococcales	GM	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,SIS
CH3_k127_9350662_4	331678.Cphamn1_1682	1.02e-70	244.0	28P4N@1|root,2ZBZT@2|Bacteria	2|Bacteria	S	Putative inner membrane protein (DUF1819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1819
CH3_k127_9350662_3	882.DVU_2026	2.32e-99	329.0	28KCG@1|root,2Z9ZE@2|Bacteria,1R8W1@1224|Proteobacteria,430BG@68525|delta/epsilon subdivisions,2WTPG@28221|Deltaproteobacteria,2MFQB@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1788)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1788
CH3_k127_9350662_0	882.DVU_2025	1e-323	999.0	COG1293@1|root,COG1293@2|Bacteria,1QUKW@1224|Proteobacteria,42T1A@68525|delta/epsilon subdivisions,2X6YM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	RNA-binding protein homologous to eukaryotic snRNP	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9350831_2	686340.Metal_3809	5.81e-62	222.0	COG1739@1|root,COG1739@2|Bacteria,1NFJC@1224|Proteobacteria,1RPBF@1236|Gammaproteobacteria,1XF7X@135618|Methylococcales	135618|Methylococcales	S	PFAM Uncharacterised protein family UPF0029, Impact, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DUF1949,UPF0029
CH3_k127_9350831_1	580332.Slit_0827	1.137e-213	673.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,44VFX@713636|Nitrosomonadales	1224|Proteobacteria	C	PFAM FAD linked oxidase domain protein	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	FAD-oxidase_C,FAD_binding_4
CH3_k127_9350831_3	857087.Metme_0631	3.07e-36	141.0	2FIY3@1|root,34AP0@2|Bacteria,1P269@1224|Proteobacteria,1SSJQ@1236|Gammaproteobacteria,1XGQ4@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9350831_0	697282.Mettu_4338	0.0	1114.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,1XDQN@135618|Methylococcales	135618|Methylococcales	G	PFAM Glycoside hydrolase, family 3, N-terminal	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CH3_k127_9350831_4	857087.Metme_1770	5.692e-35	135.0	COG1943@1|root,COG1943@2|Bacteria,1RBPH@1224|Proteobacteria,1THP6@1236|Gammaproteobacteria,1XF5F@135618|Methylococcales	135618|Methylococcales	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9362895_0	857087.Metme_2384	2.9e-217	680.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1XEEE@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
CH3_k127_9362895_2	1197906.CAJQ02000003_gene3219	8.287e-09	57.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JUGV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
CH3_k127_9362895_1	398579.Spea_3295	9.833e-30	120.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,2Q9MA@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CH3_k127_9362895_3	118168.MC7420_4165	1.239e-06	52.0	28IHG@1|root,2Z8IP@2|Bacteria,1G4GY@1117|Cyanobacteria,1H8KJ@1150|Oscillatoriales	1117|Cyanobacteria	S	SPTR Alr4702 protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
CH3_k127_9363509_1	1313421.JHBV01000032_gene1630	1.856e-15	82.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
CH3_k127_9363509_5	1562701.BBOF01000030_gene907	0.0001674	47.0	2FKB5@1|root,34BYN@2|Bacteria,1NZZD@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9363509_0	1397528.Q671_06095	4.557e-195	616.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1XR29@135619|Oceanospirillales	135619|Oceanospirillales	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
CH3_k127_9363509_2	1095769.CAHF01000010_gene1109	4.846e-10	59.0	COG3189@1|root,COG3189@2|Bacteria,1RHYB@1224|Proteobacteria,2VSIB@28216|Betaproteobacteria,477QR@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
CH3_k127_937061_2	1278309.KB907104_gene879	0.0009687	42.0	COG0330@1|root,COG0330@2|Bacteria,1R93I@1224|Proteobacteria,1RPTI@1236|Gammaproteobacteria,1XINU@135619|Oceanospirillales	135619|Oceanospirillales	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CH3_k127_937061_1	1206737.BAGF01000148_gene5908	1.332e-20	98.0	COG0329@1|root,COG0329@2|Bacteria,2IGVB@201174|Actinobacteria,4FUJG@85025|Nocardiaceae	201174|Actinobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CH3_k127_938993_7	1123518.ARWI01000001_gene1516	2.933e-18	93.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CH3_k127_938993_5	472759.Nhal_2842	3.992e-29	120.0	COG1343@1|root,COG1343@2|Bacteria,1NCYJ@1224|Proteobacteria,1SEGT@1236|Gammaproteobacteria,1X280@135613|Chromatiales	135613|Chromatiales	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	-	-	-	-	-	-	-	-	-	CRISPR_Cas2
CH3_k127_938993_1	686340.Metal_2236	4.455e-108	358.0	COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,1S36E@1236|Gammaproteobacteria,1XGCY@135618|Methylococcales	135618|Methylococcales	L	CRISPR associated protein Cas1	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas1
CH3_k127_938993_3	686340.Metal_2235	1.492e-48	183.0	2EIIA@1|root,33C9M@2|Bacteria,1NGE4@1224|Proteobacteria,1SHSI@1236|Gammaproteobacteria,1XGX9@135618|Methylococcales	135618|Methylococcales	S	CRISPR associated protein Cas1	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas1
CH3_k127_938993_6	686340.Metal_2234	4.814e-27	114.0	COG1343@1|root,COG1343@2|Bacteria,1NKK5@1224|Proteobacteria,1SH4M@1236|Gammaproteobacteria,1XGV3@135618|Methylococcales	135618|Methylococcales	L	CRISPR associated protein Cas2	-	-	-	-	-	-	-	-	-	-	-	-	CRISPR_Cas2
CH3_k127_938993_0	697282.Mettu_2091	3.208e-180	567.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1RZ95@1236|Gammaproteobacteria,1XDMQ@135618|Methylococcales	135618|Methylococcales	P	Mediates influx of magnesium ions	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CH3_k127_938993_4	870187.Thini_1596	7.754e-39	151.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,463S5@72273|Thiotrichales	72273|Thiotrichales	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
CH3_k127_938993_2	1396858.Q666_10270	3.11e-96	319.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
CH3_k127_938993_8	296591.Bpro_1318	6.325e-18	85.0	COG0582@1|root,COG0582@2|Bacteria,1R43H@1224|Proteobacteria,2VPZM@28216|Betaproteobacteria,4AHZK@80864|Comamonadaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
CH3_k127_9405237_4	697282.Mettu_0509	7.28e-12	66.0	COG4585@1|root,COG4585@2|Bacteria,1RHF6@1224|Proteobacteria,1S8ER@1236|Gammaproteobacteria,1XEPJ@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor region	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,LapD_MoxY_N
CH3_k127_9405237_1	1283300.ATXB01000001_gene566	2.358e-88	296.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1XFYM@135618|Methylococcales	135618|Methylococcales	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
CH3_k127_9405237_3	686340.Metal_3356	1.728e-66	231.0	COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1XEYA@135618|Methylococcales	135618|Methylococcales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
CH3_k127_9405237_2	697282.Mettu_1583	1.182e-80	275.0	COG1226@1|root,COG1226@2|Bacteria,1QRWR@1224|Proteobacteria,1SPPS@1236|Gammaproteobacteria,1XG34@135618|Methylococcales	135618|Methylococcales	C	PFAM Regulator of K conductance, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_N
CH3_k127_9405237_0	697282.Mettu_1584	3.299e-163	524.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria,1XG89@135618|Methylococcales	135618|Methylococcales	P	PFAM Regulator of K conductance, N-terminal	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,TrkA_N
CH3_k127_9462719_3	911239.CF149_04321	3.372e-23	100.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	belongs to the nudix hydrolase family	mutT	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	iE2348C_1286.E2348C_0104,iSDY_1059.SDY_0129	NUDIX,NUDIX_4,TMP-TENI
CH3_k127_9462719_0	857087.Metme_0466	3.029e-181	576.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1XDKE@135618|Methylococcales	135618|Methylococcales	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
CH3_k127_9462719_2	1116472.MGMO_122c00200	1.435e-32	130.0	COG0425@1|root,COG0425@2|Bacteria,1QIAC@1224|Proteobacteria,1TG4H@1236|Gammaproteobacteria,1XFM0@135618|Methylococcales	135618|Methylococcales	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
CH3_k127_9462719_1	1198232.CYCME_0023	1.601e-172	545.0	COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,1T212@1236|Gammaproteobacteria,45ZU6@72273|Thiotrichales	72273|Thiotrichales	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	ThiI
CH3_k127_9468446_2	1380355.JNIJ01000021_gene3726	7.696e-157	524.0	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2U0WY@28211|Alphaproteobacteria,3JVZN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Oxidoreductase NAD-binding domain	hcr	-	1.17.1.1	ko:K00523,ko:K21832	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
CH3_k127_9468446_11	349521.HCH_04640	3.157e-41	175.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1XRB8@135619|Oceanospirillales	135619|Oceanospirillales	T	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CH3_k127_9468446_3	1380355.JNIJ01000021_gene3727	2.41e-126	416.0	COG2346@1|root,COG3576@1|root,COG2346@2|Bacteria,COG3576@2|Bacteria,1QARU@1224|Proteobacteria,2U2J5@28211|Alphaproteobacteria,3K619@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin,Putative_PNPOx
CH3_k127_9468446_1	857087.Metme_4588	1.15e-300	931.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1XENC@135618|Methylococcales	135618|Methylococcales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CH3_k127_9468446_10	697282.Mettu_1836	6.797e-43	163.0	COG3087@1|root,COG3087@2|Bacteria,1RCC0@1224|Proteobacteria,1SBGX@1236|Gammaproteobacteria,1XF91@135618|Methylococcales	135618|Methylococcales	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
CH3_k127_9468446_13	1294143.H681_20525	1.259e-18	85.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050	Sod_Fe_C,Sod_Fe_N
CH3_k127_9468446_4	686340.Metal_0109	4.306e-98	325.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria,1XDV0@135618|Methylococcales	135618|Methylococcales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CH3_k127_9468446_9	697282.Mettu_1210	4.068e-48	177.0	2DP2V@1|root,330AH@2|Bacteria,1R3EE@1224|Proteobacteria,1T670@1236|Gammaproteobacteria,1XGE6@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3455
CH3_k127_9468446_7	935863.AWZR01000001_gene1706	5.988e-75	268.0	COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,1S57B@1236|Gammaproteobacteria,1X5IY@135614|Xanthomonadales	135614|Xanthomonadales	CG	Glycosyl transferases, related to UDP-glucuronosyltransferase	ugt	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_28,UDPGT
CH3_k127_9468446_12	877418.ATWV01000003_gene650	1.436e-40	168.0	COG2114@1|root,COG2114@2|Bacteria,2J5GP@203691|Spirochaetes	2|Bacteria	T	guanylate cyclase catalytic domain	cyaA	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
CH3_k127_9468446_6	1121374.KB891585_gene2415	1.174e-77	275.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2206 HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
CH3_k127_9468446_8	1116472.MGMO_175c00100	2.137e-70	244.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1XECD@135618|Methylococcales	135618|Methylococcales	E	GDSL-like Lipase/Acylhydrolase family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
CH3_k127_9468446_5	697282.Mettu_2349	1.338e-94	316.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1XE9K@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_9468446_0	697282.Mettu_2350	0.0	1093.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1XE8W@135618|Methylococcales	135618|Methylococcales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
CH3_k127_951277_3	857087.Metme_0637	1.546e-18	85.0	COG1993@1|root,COG1993@2|Bacteria,1N8TP@1224|Proteobacteria,1SDYH@1236|Gammaproteobacteria,1XFJY@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
CH3_k127_951277_1	857087.Metme_3951	1.28e-84	285.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1XDKY@135618|Methylococcales	135618|Methylococcales	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
CH3_k127_951277_0	697282.Mettu_0422	1.165e-240	751.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1XDTS@135618|Methylococcales	135618|Methylococcales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
CH3_k127_951277_2	686340.Metal_1400	6.578e-36	140.0	COG3404@1|root,COG3404@2|Bacteria,1R781@1224|Proteobacteria,1SFG9@1236|Gammaproteobacteria,1XEUC@135618|Methylococcales	135618|Methylococcales	E	Formiminotransferase-cyclodeaminase	fchA	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
CH3_k127_9524771_1	686340.Metal_2168	2.037e-77	265.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,1S124@1236|Gammaproteobacteria,1XEG3@135618|Methylococcales	135618|Methylococcales	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
CH3_k127_9524771_0	697282.Mettu_0186	0.0	1310.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RP0D@1236|Gammaproteobacteria,1XE04@135618|Methylococcales	135618|Methylococcales	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
CH3_k127_9535907_2	330214.NIDE0010	2.249e-33	131.0	COG1741@1|root,COG1741@2|Bacteria,3J125@40117|Nitrospirae	40117|Nitrospirae	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
CH3_k127_9535907_0	1283300.ATXB01000001_gene847	1.356e-299	929.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1XDS0@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
CH3_k127_9535907_1	697282.Mettu_0705	1.909e-93	309.0	COG1276@1|root,COG1276@2|Bacteria,1MXRN@1224|Proteobacteria,1SKDQ@1236|Gammaproteobacteria,1XDKC@135618|Methylococcales	135618|Methylococcales	P	Copper resistance	-	-	-	ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopD
CH3_k127_9554758_7	1116472.MGMO_171c00040	6.741e-97	321.0	COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,1RNQW@1236|Gammaproteobacteria,1XDWQ@135618|Methylococcales	135618|Methylococcales	C	PFAM ATPase, F1 V1 A1 complex, alpha beta subunit, nucleotide-binding domain	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
CH3_k127_9554758_4	697282.Mettu_1489	1.637e-125	412.0	COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,1RY55@1236|Gammaproteobacteria,1XDIV@135618|Methylococcales	135618|Methylococcales	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
CH3_k127_9554758_0	697282.Mettu_1490	5.814e-276	856.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,1XEM6@135618|Methylococcales	135618|Methylococcales	F	Thymidine phosphorylase	-	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
CH3_k127_9554758_13	1122134.KB893650_gene1234	1.982e-42	162.0	COG3101@1|root,COG3101@2|Bacteria,1MWTG@1224|Proteobacteria,1RNHD@1236|Gammaproteobacteria,1XK0G@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K09906	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	EpmC
CH3_k127_9554758_17	857087.Metme_0554	2.792e-11	73.0	2AWIV@1|root,31Q2Y@2|Bacteria,1QIYV@1224|Proteobacteria,1TGVI@1236|Gammaproteobacteria,1XGT6@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9554758_10	1116472.MGMO_43c00030	9.054e-72	246.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1XEB9@135618|Methylococcales	135618|Methylococcales	L	pfam nudix	-	-	-	ko:K08312	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
CH3_k127_9554758_8	697282.Mettu_1923	9.22e-97	320.0	COG0637@1|root,COG0637@2|Bacteria,1QTT8@1224|Proteobacteria,1T1GC@1236|Gammaproteobacteria,1XE2I@135618|Methylococcales	135618|Methylococcales	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CH3_k127_9554758_2	857087.Metme_4336	3.823e-208	652.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XEUG@135618|Methylococcales	135618|Methylococcales	JKL	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
CH3_k127_9554758_12	686340.Metal_0126	9.347e-58	202.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1XFBH@135618|Methylococcales	135618|Methylococcales	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CH3_k127_9554758_1	243233.MCA0056	7.17e-242	752.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1XE4H@135618|Methylococcales	135618|Methylococcales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CH3_k127_9554758_14	857087.Metme_0408	2.327e-40	150.0	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1XFJS@135618|Methylococcales	135618|Methylococcales	C	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
CH3_k127_9554758_3	697282.Mettu_1918	4.072e-134	436.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1XEGC@135618|Methylococcales	135618|Methylococcales	L	A G-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
CH3_k127_9554758_16	686340.Metal_3452	1.134e-13	74.0	2AW5V@1|root,31N0V@2|Bacteria,1QJSM@1224|Proteobacteria,1THTW@1236|Gammaproteobacteria,1XFPI@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9554758_6	686340.Metal_3453	1.12e-112	366.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria,1XET2@135618|Methylococcales	135618|Methylococcales	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
CH3_k127_9554758_9	686340.Metal_3454	5.095e-92	304.0	2E3IN@1|root,32YH3@2|Bacteria,1NA7N@1224|Proteobacteria,1SCVH@1236|Gammaproteobacteria,1XDMN@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9554758_5	697282.Mettu_1758	1.51e-116	390.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1XFYN@135618|Methylococcales	135618|Methylococcales	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
CH3_k127_9554758_15	1116472.MGMO_85c00300	1.781e-24	109.0	28WQ2@1|root,2ZIPR@2|Bacteria,1P418@1224|Proteobacteria,1THQ6@1236|Gammaproteobacteria,1XF9Q@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9554758_11	857087.Metme_4274	1.773e-70	240.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1XEE2@135618|Methylococcales	135618|Methylococcales	NU	TIGRFAM Pilus retraction protein PilT	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
CH3_k127_9558140_5	1198232.CYCME_1568	1.592e-41	154.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,46068@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CH3_k127_9558140_2	686340.Metal_0074	5.135e-83	280.0	COG4636@1|root,COG4636@2|Bacteria,1RKJS@1224|Proteobacteria,1S65M@1236|Gammaproteobacteria,1XG7N@135618|Methylococcales	135618|Methylococcales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CH3_k127_9558140_1	697282.Mettu_2729	2.577e-156	496.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1XDR5@135618|Methylococcales	135618|Methylococcales	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
CH3_k127_9558140_4	56107.Cylst_2228	6.914e-53	190.0	COG4636@1|root,COG4636@2|Bacteria,1G5FE@1117|Cyanobacteria,1HQWH@1161|Nostocales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CH3_k127_9558140_3	857087.Metme_2549	3.41e-69	240.0	COG4636@1|root,COG4636@2|Bacteria,1N1KS@1224|Proteobacteria,1TGY7@1236|Gammaproteobacteria,1XG5C@135618|Methylococcales	135618|Methylococcales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
CH3_k127_9558140_0	1116472.MGMO_166c00050	9.393e-178	561.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1XEHF@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
CH3_k127_9601972_1	697282.Mettu_1232	3.926e-109	366.0	COG0715@1|root,COG0715@2|Bacteria,1MWUA@1224|Proteobacteria,1S2B3@1236|Gammaproteobacteria,1XDIW@135618|Methylococcales	135618|Methylococcales	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
CH3_k127_9601972_0	697282.Mettu_1233	1.23e-111	365.0	COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,1RR15@1236|Gammaproteobacteria,1XEC4@135618|Methylococcales	135618|Methylococcales	P	PFAM Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
CH3_k127_9601972_2	697282.Mettu_1234	5.093e-100	332.0	COG1116@1|root,COG1116@2|Bacteria,1MU6C@1224|Proteobacteria,1SZ7W@1236|Gammaproteobacteria,1XEMA@135618|Methylococcales	135618|Methylococcales	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
CH3_k127_9614526_0	697282.Mettu_1623	7.549e-142	454.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XEFM@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CH3_k127_9614526_1	697282.Mettu_1624	3.761e-89	300.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1XEU6@135618|Methylococcales	135618|Methylococcales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
CH3_k127_9614526_5	857087.Metme_4140	1.516e-25	111.0	2DP6U@1|root,330T2@2|Bacteria,1N7R9@1224|Proteobacteria,1SDI8@1236|Gammaproteobacteria,1XFBA@135618|Methylococcales	135618|Methylococcales	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA
CH3_k127_9614526_2	1116472.MGMO_35c00040	3.598e-77	267.0	COG1525@1|root,COG1525@2|Bacteria,1RKRQ@1224|Proteobacteria,1S5D6@1236|Gammaproteobacteria,1XDMG@135618|Methylococcales	135618|Methylococcales	L	PFAM Staphylococcal nuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SNase
CH3_k127_9614526_4	697282.Mettu_0040	1.014e-57	204.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1XF4C@135618|Methylococcales	135618|Methylococcales	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
CH3_k127_9614526_3	1198232.CYCME_1862	5.408e-69	239.0	COG0784@1|root,COG5001@1|root,COG0784@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,4620Q@72273|Thiotrichales	72273|Thiotrichales	T	Diguanylate cyclase phosphodiesterase (GGDEF EAL domains) with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
CH3_k127_965620_0	1267005.KB911258_gene146	2.593e-155	497.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,3N8EG@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
CH3_k127_965620_1	439235.Dalk_4286	1.568e-90	310.0	COG0388@1|root,COG0388@2|Bacteria,1RENA@1224|Proteobacteria,42VUB@68525|delta/epsilon subdivisions,2WS8Y@28221|Deltaproteobacteria,2MMNH@213118|Desulfobacterales	28221|Deltaproteobacteria	H	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
CH3_k127_965620_2	1122603.ATVI01000009_gene2646	3.761e-17	81.0	COG1075@1|root,COG1075@2|Bacteria,1MXMP@1224|Proteobacteria,1RYZM@1236|Gammaproteobacteria,1X44F@135614|Xanthomonadales	135614|Xanthomonadales	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
CH3_k127_9787153_2	686340.Metal_1653	1.825e-37	142.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XDMY@135618|Methylococcales	135618|Methylococcales	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CH3_k127_9787153_1	686340.Metal_1653	2.242e-63	221.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XDMY@135618|Methylococcales	135618|Methylococcales	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CH3_k127_9787153_3	857087.Metme_0881	2.558e-16	83.0	2AW6G@1|root,31N1H@2|Bacteria,1QJTA@1224|Proteobacteria,1THUJ@1236|Gammaproteobacteria,1XFRT@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9787153_0	697282.Mettu_3264	3.141e-267	825.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1XEEH@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
CH3_k127_982120_10	697282.Mettu_2026	3.473e-11	63.0	2DPP8@1|root,332V3@2|Bacteria,1NJM6@1224|Proteobacteria,1SIP1@1236|Gammaproteobacteria,1XFGW@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF3240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3240
CH3_k127_982120_0	857087.Metme_4596	8.798e-268	829.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XEVV@135618|Methylococcales	135618|Methylococcales	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
CH3_k127_982120_2	857087.Metme_4595	1.013e-109	356.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1XEN2@135618|Methylococcales	135618|Methylococcales	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CH3_k127_982120_5	870967.VIS19158_04806	4.891e-30	120.0	2BHNR@1|root,32BRP@2|Bacteria,1PJW5@1224|Proteobacteria,1T98U@1236|Gammaproteobacteria,1XZDV@135623|Vibrionales	135623|Vibrionales	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
CH3_k127_982120_7	757424.Hsero_3426	7.56e-26	108.0	2DPYH@1|root,333YR@2|Bacteria,1NF9G@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CH3_k127_982120_6	314278.NB231_01878	6.725e-28	114.0	2ED2F@1|root,336ZC@2|Bacteria,1N758@1224|Proteobacteria,1SE5R@1236|Gammaproteobacteria,1X19V@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
CH3_k127_982120_3	1128427.KB904821_gene1408	8.525e-92	321.0	COG0457@1|root,COG0457@2|Bacteria,1G3JD@1117|Cyanobacteria,1H853@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_982120_8	357808.RoseRS_4372	1.495e-16	81.0	2E712@1|root,331JU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_982120_9	946483.Cenrod_0842	4.329e-14	74.0	2E7P1@1|root,31AV7@2|Bacteria,1NNQI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_982120_4	324925.Ppha_1720	6.967e-41	155.0	COG3744@1|root,COG3744@2|Bacteria	2|Bacteria	S	ribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CH3_k127_982120_1	686340.Metal_3442	2.702e-144	464.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1XEAU@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
CH3_k127_9849440_3	62928.azo2352	1.007e-26	110.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2VTXZ@28216|Betaproteobacteria,2KX92@206389|Rhodocyclales	206389|Rhodocyclales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
CH3_k127_9849440_2	62928.azo2353	2.223e-67	231.0	COG0394@1|root,COG0394@2|Bacteria,1REU2@1224|Proteobacteria,2VS5B@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Low molecular weight phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
CH3_k127_9849440_1	62928.azo2354	8.6e-173	548.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,2KUSU@206389|Rhodocyclales	206389|Rhodocyclales	P	COG0798 Arsenite efflux pump ACR3 and related permeases	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
CH3_k127_9849440_0	697282.Mettu_1547	1.156e-180	571.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1XEHZ@135618|Methylococcales	135618|Methylococcales	C	FAD linked oxidases, C-terminal domain	-	-	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120	-	R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
CH3_k127_9875701_3	1415780.JPOG01000001_gene3368	6.502e-12	73.0	COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,1QZSB@1224|Proteobacteria	1224|Proteobacteria	T	Gaf domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9875701_0	398767.Glov_2566	9.369e-60	214.0	COG1373@1|root,COG1373@2|Bacteria,1R7NY@1224|Proteobacteria,42WRJ@68525|delta/epsilon subdivisions,2X6IR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CH3_k127_9875701_5	1348657.M622_12905	4.746e-11	66.0	COG0732@1|root,COG0732@2|Bacteria,1Q4FB@1224|Proteobacteria,2VR1G@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
CH3_k127_9875701_1	644801.Psest_3406	4.513e-51	186.0	COG0732@1|root,COG0732@2|Bacteria,1Q4FB@1224|Proteobacteria,1RS7D@1236|Gammaproteobacteria,1Z3CQ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	V	COG0732 Restriction endonuclease S subunits	hsdS	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
CH3_k127_9875701_4	1316936.K678_06577	1.309e-11	66.0	COG0732@1|root,COG0732@2|Bacteria,1Q4FB@1224|Proteobacteria,2U8UD@28211|Alphaproteobacteria,2JWQ9@204441|Rhodospirillales	204441|Rhodospirillales	V	Type I restriction modification DNA specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	Methylase_S
CH3_k127_9875701_2	1116472.MGMO_15c00030	1.381e-12	69.0	COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1XDP4@135618|Methylococcales	135618|Methylococcales	L	PFAM Restriction endonuclease, type I, EcoRI, R subunit Type III, Res subunit, N-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N,ResIII
CH3_k127_9903306_1	686340.Metal_1824	3.924e-86	287.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XEX2@135618|Methylococcales	135618|Methylococcales	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
CH3_k127_9903306_6	1116472.MGMO_8c00310	8.834e-07	50.0	COG1036@1|root,COG1036@2|Bacteria,1RD5I@1224|Proteobacteria,1S59C@1236|Gammaproteobacteria,1XDQH@135618|Methylococcales	135618|Methylococcales	C	PFAM Flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
CH3_k127_9903306_0	697282.Mettu_2920	3.735e-235	735.0	COG0294@1|root,COG0294@2|Bacteria,1MWM3@1224|Proteobacteria,1RZMG@1236|Gammaproteobacteria,1XEAQ@135618|Methylococcales	135618|Methylococcales	H	PFAM Dihydropteroate synthase, DHPS	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9903306_4	1283300.ATXB01000001_gene1456	8.37e-72	250.0	COG2457@1|root,COG2457@2|Bacteria,1RD0V@1224|Proteobacteria,1S4RM@1236|Gammaproteobacteria,1XEYH@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
CH3_k127_9903306_3	697282.Mettu_2922	7.601e-74	258.0	COG0784@1|root,COG1891@1|root,COG0784@2|Bacteria,COG1891@2|Bacteria,1RGX0@1224|Proteobacteria,1S6UW@1236|Gammaproteobacteria,1XF0B@135618|Methylococcales	135618|Methylococcales	T	4-HFC-P synthase	-	-	-	-	-	-	-	-	-	-	-	-	4HFCP_synth
CH3_k127_9903306_2	686340.Metal_2395	9.419e-82	282.0	2BWZZ@1|root,2Z86E@2|Bacteria,1MW89@1224|Proteobacteria,1S85K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2927)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2927
CH3_k127_9903306_5	243233.MCA1561	3.992e-66	228.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XG63@135618|Methylococcales	135618|Methylococcales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CH3_k127_9973496_1	697282.Mettu_3247	4.475e-61	216.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,1S7GD@1236|Gammaproteobacteria,1XF5A@135618|Methylococcales	135618|Methylococcales	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
CH3_k127_9973496_2	697282.Mettu_3246	4.547e-61	215.0	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,1S8HH@1236|Gammaproteobacteria,1XF8H@135618|Methylococcales	135618|Methylococcales	K	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
CH3_k127_9973496_3	686340.Metal_2270	1.465e-59	210.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,1S620@1236|Gammaproteobacteria,1XFFB@135618|Methylococcales	135618|Methylococcales	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9973496_0	452471.Aasi_0854	5.713e-63	229.0	COG0790@1|root,COG0790@2|Bacteria,4NMCC@976|Bacteroidetes,47QS2@768503|Cytophagia	976|Bacteroidetes	KLT	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Pkinase,Sel1,Tox-ODYAM1,U-box
CH3_k127_9973496_4	857087.Metme_4007	9.308e-54	194.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,1SZR6@1236|Gammaproteobacteria,1XFCK@135618|Methylococcales	135618|Methylococcales	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9973496_5	697282.Mettu_3243	3.678e-27	111.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,1RYUT@1236|Gammaproteobacteria,1XEKZ@135618|Methylococcales	135618|Methylococcales	S	PFAM Cytochrome d1	-	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
CH3_k127_9977758_2	1288494.EBAPG3_12530	1.438e-30	123.0	2A022@1|root,314J6@2|Bacteria,1PU9G@1224|Proteobacteria,2WARG@28216|Betaproteobacteria,373H9@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1840)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1840
CH3_k127_9977758_3	243233.MCA0552	2.212e-22	100.0	2F1EJ@1|root,33UF9@2|Bacteria,1NV3G@1224|Proteobacteria,1TI1Z@1236|Gammaproteobacteria,1XGBM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9977758_5	243233.MCA0552	8.269e-18	93.0	2F1EJ@1|root,33UF9@2|Bacteria,1NV3G@1224|Proteobacteria,1TI1Z@1236|Gammaproteobacteria,1XGBM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9977758_4	243233.MCA0552	4.41e-20	94.0	2F1EJ@1|root,33UF9@2|Bacteria,1NV3G@1224|Proteobacteria,1TI1Z@1236|Gammaproteobacteria,1XGBM@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CH3_k127_9977758_0	697282.Mettu_1554	1.055e-41	154.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1XEIH@135618|Methylococcales	135618|Methylococcales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
CH3_k127_9995291_5	857087.Metme_3913	3.205e-43	160.0	COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,1S672@1236|Gammaproteobacteria,1XF96@135618|Methylococcales	135618|Methylococcales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CH3_k127_9995291_0	697282.Mettu_3001	5.982e-221	709.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1XDUM@135618|Methylococcales	135618|Methylococcales	S	Competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
CH3_k127_9995291_4	243233.MCA2626	2.004e-57	216.0	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,1XF7K@135618|Methylococcales	135618|Methylococcales	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
CH3_k127_9995291_2	1123367.C666_01500	1.545e-126	407.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2VK6T@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
CH3_k127_9995291_3	1283300.ATXB01000001_gene1477	7.155e-87	292.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1XDWU@135618|Methylococcales	135618|Methylococcales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
CH3_k127_9995291_1	697282.Mettu_3004	3.72e-138	443.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1XE02@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
## 2582 queries scanned
## Total time (seconds): 5.243212699890137
## Rate: 492.45 q/s