## Thu Nov 7 05:28:04 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS1_bin.132.fa -m mmseqs --itype genome -o CMS1_bin.132 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS1_bin.132 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs CMS1_k127_1002875_2 380749.HY04AAS1_1534 1.987e-09 64.0 COG1290@1|root,COG1290@2|Bacteria,2G4JA@200783|Aquificae 200783|Aquificae C PFAM Cytochrome b b6 domain - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B CMS1_k127_1002875_0 1379698.RBG1_1C00001G0779 5.954e-65 244.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS1_k127_1002875_1 913865.DOT_3426 1.208e-11 73.0 COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,24YVE@186801|Clostridia 186801|Clostridia C NapC/NirT cytochrome c family, N-terminal region - - - - - - - - - - - - Cytochrom_NNT CMS1_k127_10058_2 1254432.SCE1572_02795 2.061e-115 398.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS1_k127_10058_1 445975.COLSTE_01595 2.778e-132 447.0 COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4CU9B@84998|Coriobacteriia 84998|Coriobacteriia S ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn CMS1_k127_10058_5 1122604.JONR01000022_gene664 8.585e-05 53.0 290RZ@1|root,2ZNE4@2|Bacteria,1P6TN@1224|Proteobacteria,1SVGT@1236|Gammaproteobacteria,1X8NF@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - CMS1_k127_10058_0 1283300.ATXB01000001_gene318 1.564e-149 483.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1XEW5@135618|Methylococcales 135618|Methylococcales C Apoptosis-inducing factor, mitochondrion-associated, C-term - - - - - - - - - - - - AIF_C,Pyr_redox_2 CMS1_k127_10058_3 1437824.BN940_06796 2.874e-75 275.0 COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2VKTD@28216|Betaproteobacteria,3T905@506|Alcaligenaceae 28216|Betaproteobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 CMS1_k127_10058_4 926550.CLDAP_25100 3.241e-15 85.0 COG0221@1|root,COG0221@2|Bacteria,2G6T4@200795|Chloroflexi 200795|Chloroflexi C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase CMS1_k127_1008269_1 290397.Adeh_0635 2.627e-45 173.0 COG4969@1|root,COG4969@2|Bacteria,1Q5KV@1224|Proteobacteria,42UIT@68525|delta/epsilon subdivisions,2WQNS@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl CMS1_k127_1008269_0 404589.Anae109_0679 4.901e-78 282.0 COG0457@1|root,COG0457@2|Bacteria,1MZCR@1224|Proteobacteria,42UQJ@68525|delta/epsilon subdivisions,2WQIF@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_1008269_2 290397.Adeh_0633 2.272e-41 162.0 COG1277@1|root,COG1277@2|Bacteria,1NCXV@1224|Proteobacteria,42VK2@68525|delta/epsilon subdivisions,2WRNT@28221|Deltaproteobacteria,2Z31A@29|Myxococcales 28221|Deltaproteobacteria S ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_2 CMS1_k127_1009327_1 1379698.RBG1_1C00001G0806 3.082e-120 396.0 COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria 2|Bacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 CMS1_k127_1009327_3 439235.Dalk_1739 5.215e-50 192.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,42ZTX@68525|delta/epsilon subdivisions,2WVID@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - iAF987.Gmet_2224 ECH_1 CMS1_k127_1009327_0 1379698.RBG1_1C00001G0805 4.858e-184 588.0 COG1012@1|root,COG1012@2|Bacteria,2NNWB@2323|unclassified Bacteria 2|Bacteria C Belongs to the aldehyde dehydrogenase family aldH - 1.2.1.3 ko:K00128,ko:K00138 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS1_k127_1009327_4 1380350.JIAP01000026_gene3386 7.383e-40 161.0 COG0346@1|root,COG0346@2|Bacteria,1MZD3@1224|Proteobacteria,2UB4F@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase CMS1_k127_1009327_2 1399115.U719_02035 8.11e-90 306.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,3WF7J@539002|Bacillales incertae sedis 91061|Bacilli I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain hbd - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N CMS1_k127_1009327_5 1123368.AUIS01000013_gene815 4.069e-20 102.0 COG4313@1|root,COG4313@2|Bacteria,1R5Z9@1224|Proteobacteria,1T97C@1236|Gammaproteobacteria,2NDZP@225057|Acidithiobacillales 225057|Acidithiobacillales C Protein involved in meta-pathway of phenol degradation - - - - - - - - - - - - - CMS1_k127_1009774_9 749414.SBI_00790 0.0001752 49.0 COG0500@1|root,COG2226@2|Bacteria,2I3TI@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase domain - - 2.1.1.156 ko:K14374,ko:K18896 ko00260,ko00522,ko01052,ko01130,map00260,map00522,map01052,map01130 M00777 R06476,R06477,R06478,R06479,R10060 RC00003,RC00466,RC03038 ko00000,ko00001,ko00002,ko01000,ko01008 - - - Methyltransf_11,Methyltransf_25 CMS1_k127_1009774_2 880073.Calab_0215 1.074e-61 220.0 COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria 2|Bacteria T Calcineurin-like phosphoesterase superfamily domain apaH - - - - - - - - - - - Metallophos_2 CMS1_k127_1009774_5 1254432.SCE1572_42360 1.776e-27 120.0 COG0781@1|root,COG0781@2|Bacteria,1N94P@1224|Proteobacteria,42SEA@68525|delta/epsilon subdivisions,2WQP9@28221|Deltaproteobacteria,2YVKR@29|Myxococcales 28221|Deltaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB CMS1_k127_1009774_4 1382304.JNIL01000001_gene1648 1.024e-40 170.0 COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4HFRA@91061|Bacilli,279P7@186823|Alicyclobacillaceae 91061|Bacilli H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08940 DMRL_synthase CMS1_k127_1009774_0 518766.Rmar_2056 4.892e-141 470.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,4NF6I@976|Bacteroidetes,1FIT0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 CMS1_k127_1009774_3 644966.Tmar_1416 2.576e-47 184.0 COG0108@1|root,COG0307@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0307@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,3WCXY@538999|Clostridiales incertae sedis 186801|Clostridia H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10830 DHBP_synthase,GTP_cyclohydro2 CMS1_k127_1009774_1 644966.Tmar_1991 2.39e-95 329.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,3WCD3@538999|Clostridiales incertae sedis 186801|Clostridia H Riboflavin biosynthesis protein RibD ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 CMS1_k127_1009774_7 459349.CLOAM0442 5.118e-15 90.0 COG1361@1|root,COG4412@1|root,COG1361@2|Bacteria,COG4412@2|Bacteria,2NRBU@2323|unclassified Bacteria 2|Bacteria M Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - CHU_C,Cleaved_Adhesin,DUF4968,DUF5110,F5_F8_type_C,FlgD_ig,Glyco_hydro_31,Peptidase_C25,Peptidase_C25_C,Propeptide_C25,W_rich_C,fn3 CMS1_k127_1009774_8 1173025.GEI7407_2522 3.057e-05 56.0 COG3420@1|root,COG3420@2|Bacteria,1G2FG@1117|Cyanobacteria,1H7WG@1150|Oscillatoriales 1117|Cyanobacteria P S-layer homology domain - - - - - - - - - - - - DUF1565,SLH CMS1_k127_1009774_6 555079.Toce_0739 2.608e-21 94.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,42EWM@68295|Thermoanaerobacterales 186801|Clostridia L Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC CMS1_k127_1016804_2 1379270.AUXF01000006_gene26 8.634e-13 77.0 COG0457@1|root,COG0457@2|Bacteria,1ZU0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 CMS1_k127_1016804_0 1379698.RBG1_1C00001G1247 1.165e-150 492.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria 2|Bacteria E Formiminotransferase-cyclodeaminase ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K01746,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N CMS1_k127_1016804_1 562970.Btus_0929 6.791e-100 342.0 COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,4HAVY@91061|Bacilli,27837@186823|Alicyclobacillaceae 91061|Bacilli Q Amidohydrolase family hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU39370 Amidohydro_1,Amidohydro_3 CMS1_k127_1016804_3 1089546.AQUI01000002_gene1105 9.445e-08 53.0 COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,408U1@622450|Actinopolysporales 201174|Actinobacteria E Urocanase C-terminal domain hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N CMS1_k127_102282_0 204669.Acid345_1052 3.241e-80 292.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia 204432|Acidobacteriia KLT Tetratricopeptide repeats - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C CMS1_k127_102282_2 351607.Acel_1033 6.937e-29 126.0 COG4747@1|root,COG4747@2|Bacteria 2|Bacteria - - hom - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00570 R00220,R00996,R01513,R01773,R01775 RC00031,RC00087,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3 CMS1_k127_102282_5 1123368.AUIS01000005_gene395 4.64e-09 70.0 COG0457@1|root,COG0457@2|Bacteria,1QV5B@1224|Proteobacteria,1T292@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16,TPR_19,TPR_8 CMS1_k127_102282_1 1158338.JNLJ01000001_gene905 3.464e-73 271.0 COG2885@1|root,COG2885@2|Bacteria,2G4S4@200783|Aquificae 200783|Aquificae M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_YMGG,OmpA,TSP_3 CMS1_k127_102282_3 234267.Acid_6789 6.71e-12 78.0 COG2823@1|root,COG2823@2|Bacteria,3Y99E@57723|Acidobacteria 57723|Acidobacteria S Periplasmic or secreted lipoprotein - - - - - - - - - - - - - CMS1_k127_102282_4 357808.RoseRS_2883 1.019e-11 72.0 COG3743@1|root,COG3743@2|Bacteria,2G96D@200795|Chloroflexi 200795|Chloroflexi S Domain of unknown function (DUF4332) - - - - - - - - - - - - DUF4332 CMS1_k127_1023679_1 861299.J421_3883 3.002e-71 243.0 COG1429@1|root,COG1429@2|Bacteria 2|Bacteria H ligase activity, forming nitrogen-metal bonds cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel,Glyco_hydro_63 CMS1_k127_1023679_4 314278.NB231_12536 1.202e-48 190.0 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1SYT9@1236|Gammaproteobacteria,1X25R@135613|Chromatiales 135613|Chromatiales G PFAM glucosamine galactosamine-6-phosphate isomerase - - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso CMS1_k127_1023679_0 211165.AJLN01000133_gene5922 2.036e-92 323.0 COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria 1117|Cyanobacteria U Belongs to the MIP aquaporin (TC 1.A.8) family - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP CMS1_k127_1023679_2 861299.J421_1880 3.889e-56 216.0 COG1672@1|root,COG1672@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DM13 CMS1_k127_1023679_3 1122179.KB890423_gene2364 1.537e-54 200.0 COG2303@1|root,COG2303@2|Bacteria,4NEF2@976|Bacteroidetes,1IXR8@117747|Sphingobacteriia 976|Bacteroidetes E GMC oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 CMS1_k127_1023819_0 1382358.JHVN01000007_gene307 3.872e-79 276.0 COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,4HA9W@91061|Bacilli,21V54@150247|Anoxybacillus 1239|Firmicutes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N CMS1_k127_1023819_1 204669.Acid345_2164 1.63e-23 105.0 COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria,2JJGU@204432|Acidobacteriia 204432|Acidobacteriia S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_1026523_2 1379698.RBG1_1C00001G1097 5.045e-37 143.0 COG0820@1|root,COG0820@2|Bacteria,2NP4V@2323|unclassified Bacteria 2|Bacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM CMS1_k127_1026523_1 404589.Anae109_3408 6.163e-56 215.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2YUYF@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 CMS1_k127_1026523_0 1125863.JAFN01000001_gene1650 4.66e-91 312.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_1027042_1 518766.Rmar_1348 5.608e-83 289.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_1027042_0 1379698.RBG1_1C00001G0178 1.826e-86 297.0 COG2265@1|root,COG2265@2|Bacteria,2NNWX@2323|unclassified Bacteria 2|Bacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr CMS1_k127_1029886_0 562970.Btus_0928 1.803e-256 801.0 COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,4H9NH@91061|Bacilli,2782U@186823|Alicyclobacillaceae 91061|Bacilli E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N CMS1_k127_1029886_1 1006004.GBAG_1561 8.624e-70 243.0 COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria 1236|Gammaproteobacteria E histidine ammonia-lyase hutH GO:0003674,GO:0003824,GO:0004397,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic CMS1_k127_1030640_1 272558.10176500 4.722e-108 366.0 COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli,1ZDF2@1386|Bacillus 91061|Bacilli E Peptidase dimerisation domain dapE - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS1_k127_1030640_2 1502851.FG93_05230 4.49e-16 93.0 COG3848@1|root,COG3848@2|Bacteria,1R7DS@1224|Proteobacteria,2U3SK@28211|Alphaproteobacteria,3JSC8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Pyruvate phosphate dikinase - - - - - - - - - - - - - CMS1_k127_1030640_0 349124.Hhal_0421 4.01e-112 382.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 CMS1_k127_1030640_3 446466.Cfla_1196 3.056e-06 49.0 COG0259@1|root,COG0259@2|Bacteria,2GKP3@201174|Actinobacteria,4F2QN@85016|Cellulomonadaceae 201174|Actinobacteria H Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region pdxH_1 - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx CMS1_k127_1030772_1 338963.Pcar_2785 2.539e-40 155.0 COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,42S1Q@68525|delta/epsilon subdivisions,2WNNS@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM Integral membrane protein TerC - - - - - - - - - - - - TerC CMS1_k127_1030772_0 330214.NIDE1289 3.685e-236 751.0 COG0058@1|root,COG0058@2|Bacteria,3J0W1@40117|Nitrospirae 40117|Nitrospirae G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase CMS1_k127_1030772_2 1128421.JAGA01000003_gene2944 5.224e-38 165.0 COG1640@1|root,COG1640@2|Bacteria,2NP2W@2323|unclassified Bacteria 2|Bacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 iJN678.malQ Glyco_hydro_77 CMS1_k127_1033058_0 1047013.AQSP01000131_gene1822 1.07e-170 544.0 COG4666@1|root,COG4666@2|Bacteria,2NQNY@2323|unclassified Bacteria 2|Bacteria S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - - CMS1_k127_1033058_3 1047013.AQSP01000131_gene1820 1.195e-45 173.0 28NEN@1|root,2ZQSB@2|Bacteria,2NRHN@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1033058_1 1047013.AQSP01000131_gene1824 3.059e-70 251.0 28JNG@1|root,2Z9ES@2|Bacteria,2NPDF@2323|unclassified Bacteria 2|Bacteria - - pgsW - - - - - - - - - - - - CMS1_k127_1033058_4 1047013.AQSP01000131_gene1825 8.576e-30 126.0 29EG8@1|root,334DW@2|Bacteria,2NPTE@2323|unclassified Bacteria 2|Bacteria S Capsule biosynthesis CapC capC - - ko:K22116 - - - - ko00000 - - - Caps_synth_CapC CMS1_k127_1033058_2 1047013.AQSP01000131_gene1826 1.093e-63 231.0 COG0771@1|root,COG0771@2|Bacteria,2NPCH@2323|unclassified Bacteria 2|Bacteria M Mur ligase middle domain murD - 3.4.21.10,6.3.2.13,6.3.2.9 ko:K01317,ko:K01925,ko:K01928,ko:K01932 ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100 - R02783,R02788 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01002,ko01011,ko04131 - - - DUF1727,Mur_ligase_C,Mur_ligase_M CMS1_k127_1033177_0 234267.Acid_6681 6.597e-189 596.0 COG1271@1|root,COG1271@2|Bacteria,3Y44V@57723|Acidobacteria 57723|Acidobacteria C Cytochrome bd terminal oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I CMS1_k127_1033177_1 234267.Acid_6682 9.574e-134 438.0 COG1294@1|root,COG1294@2|Bacteria,3Y3UT@57723|Acidobacteria 57723|Acidobacteria C Cytochrome d ubiquinol oxidase, subunit II - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II CMS1_k127_1033743_4 518766.Rmar_2442 1.229e-09 68.0 COG0737@1|root,COG0737@2|Bacteria,4PNDC@976|Bacteroidetes,1FJX0@1100069|Bacteroidetes Order II. Incertae sedis 2|Bacteria F pectinesterase activity - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - LRR_5,SBP_bac_8,TAT_signal CMS1_k127_1033743_2 1150599.MPHLEI_12401 3.039e-66 243.0 COG3315@1|root,COG3315@2|Bacteria,2GNGD@201174|Actinobacteria,234ZU@1762|Mycobacteriaceae 201174|Actinobacteria H Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - - - - - - - - - - LCM CMS1_k127_1033743_0 1415780.JPOG01000001_gene123 5.401e-182 590.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1X3DB@135614|Xanthomonadales 135614|Xanthomonadales L DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind CMS1_k127_1033743_3 929704.Myrod_1811 1.66e-14 83.0 2CK2Y@1|root,32SBF@2|Bacteria,4NTZD@976|Bacteroidetes,1I4T5@117743|Flavobacteriia,47J3P@76831|Myroides 976|Bacteroidetes S Photosynthetic reaction centre cytochrome C subunit - - - ko:K13992 - - - - ko00000,ko00194 - - - CytoC_RC CMS1_k127_1033743_1 204669.Acid345_1455 1.037e-91 319.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia 204432|Acidobacteriia KLT Tetratricopeptide repeats - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C CMS1_k127_1037318_0 1458357.BG58_12395 1.641e-64 224.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VZZH@28216|Betaproteobacteria,1KGQ1@119060|Burkholderiaceae 28216|Betaproteobacteria I Biotin carboxylase C-terminal domain accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS1_k127_1037318_1 861299.J421_3532 1.281e-48 190.0 COG2045@1|root,COG2045@2|Bacteria,1ZTM8@142182|Gemmatimonadetes 142182|Gemmatimonadetes H 2-phosphosulpholactate phosphatase comB - 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp CMS1_k127_1037318_2 880073.Calab_2504 2.054e-29 121.0 COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ CMS1_k127_1037625_2 1382356.JQMP01000004_gene217 9.793e-19 89.0 COG1321@1|root,COG1321@2|Bacteria,2G6N4@200795|Chloroflexi,27YBV@189775|Thermomicrobia 189775|Thermomicrobia K FeoA - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress,FeoA CMS1_k127_1037625_3 1134912.AJTV01000001_gene1451 0.0003 49.0 COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria,3712S@31993|Methylocystaceae 28211|Alphaproteobacteria C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 CMS1_k127_1037625_0 1459636.NTE_01395 3.163e-107 363.0 COG2132@1|root,arCOG03914@2157|Archaea,41S77@651137|Thaumarchaeota 651137|Thaumarchaeota Q PFAM Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_1037625_1 266117.Rxyl_0084 1.2e-47 184.0 COG0428@1|root,COG0428@2|Bacteria,2ICIQ@201174|Actinobacteria,4CSVK@84995|Rubrobacteria 84995|Rubrobacteria P Mediates zinc uptake. May also transport other divalent cations - - - - - - - - - - - - - CMS1_k127_1040120_0 1123267.JONN01000001_gene1238 1.913e-197 640.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP CMS1_k127_1040120_2 1304880.JAGB01000002_gene2153 1.915e-27 119.0 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia 186801|Clostridia K TIGRFAM RNA polymerase sigma factor, sigma-70 family algU - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_1040120_4 435591.BDI_3560 1.14e-07 62.0 COG1366@1|root,COG1366@2|Bacteria,4NZCC@976|Bacteroidetes,2FVWU@200643|Bacteroidia 976|Bacteroidetes T STAS domain - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS CMS1_k127_1040120_5 465541.ATCJ01000005_gene2230 0.0002113 54.0 COG2172@1|root,COG2172@2|Bacteria,2IG8T@201174|Actinobacteria 201174|Actinobacteria T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2 CMS1_k127_1040120_1 448385.sce7671 1.453e-104 363.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,42T5F@68525|delta/epsilon subdivisions,2WQVP@28221|Deltaproteobacteria,2YU42@29|Myxococcales 28221|Deltaproteobacteria C FMN-dependent dehydrogenase - - 1.1.3.46 ko:K16422 ko00261,ko01055,ko01130,map00261,map01055,map01130 - R06633 RC00240 ko00000,ko00001,ko01000 - - - FMN_dh CMS1_k127_1040120_3 1254432.SCE1572_32215 5.649e-22 112.0 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2WRHK@28221|Deltaproteobacteria,2Z03M@29|Myxococcales 28221|Deltaproteobacteria S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 CMS1_k127_1041779_1 1157490.EL26_22760 5.167e-76 271.0 COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,4HADV@91061|Bacilli,279NE@186823|Alicyclobacillaceae 91061|Bacilli J Threonyl and Alanyl tRNA synthetase second additional domain alaS_2 - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS1_k127_1041779_0 1499967.BAYZ01000011_gene5215 1.421e-126 439.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NNRF@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - BSP,Bac_surface_Ag,PD40,Peptidase_MA_2 CMS1_k127_105140_3 1158345.JNLL01000001_gene1655 5.575e-24 110.0 COG1610@1|root,COG1610@2|Bacteria,2G4V2@200783|Aquificae 200783|Aquificae S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY CMS1_k127_105140_2 690850.Desaf_3380 1.237e-26 126.0 COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,2MA1B@213115|Desulfovibrionales 28221|Deltaproteobacteria Q O-methyltransferase, family 2 - - - - - - - - - - - - Dimerisation2,Methyltransf_2 CMS1_k127_105140_1 219305.MCAG_02765 7.382e-53 197.0 COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria,4DBAI@85008|Micromonosporales 201174|Actinobacteria L Belongs to the FPG family mutM1 - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS CMS1_k127_105140_4 153948.NAL212_0218 1.229e-23 117.0 COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,2VMAB@28216|Betaproteobacteria,372KF@32003|Nitrosomonadales 28216|Betaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS1_k127_105140_0 1278073.MYSTI_04893 4.858e-83 302.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2YZUC@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23 CMS1_k127_105140_5 452637.Oter_1552 4.14e-10 61.0 COG3696@1|root,COG3696@2|Bacteria,46SJ1@74201|Verrucomicrobia,3K7EV@414999|Opitutae 414999|Opitutae P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran CMS1_k127_1051900_5 1273125.Rrhod_1296 2.781e-12 80.0 COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4FTZW@85025|Nocardiaceae 201174|Actinobacteria Q MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_1051900_2 1051632.TPY_2568 4.452e-59 215.0 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,3WD37@538999|Clostridiales incertae sedis 186801|Clostridia V FtsX-like permease family - - - ko:K02003,ko:K02004,ko:K05685,ko:K09810 ko02010,map02010 M00255,M00258,M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12,3.A.1.125 - - ABC_tran,FtsX CMS1_k127_1051900_0 204669.Acid345_3065 4.347e-191 622.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,3Y5CQ@57723|Acidobacteria,2JKVX@204432|Acidobacteriia 204432|Acidobacteriia C Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO CMS1_k127_1051900_1 1382306.JNIM01000001_gene2674 2.162e-120 396.0 COG0492@1|root,COG0492@2|Bacteria,2G5Z5@200795|Chloroflexi 200795|Chloroflexi C FAD-dependent pyridine nucleotide-disulphide oxidoreductase trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_1051900_3 521098.Aaci_0861 2.725e-47 179.0 COG2353@1|root,COG2353@2|Bacteria,1V1NX@1239|Firmicutes,4HFXF@91061|Bacilli 91061|Bacilli S Belongs to the UPF0312 family - - - - - - - - - - - - YceI CMS1_k127_1051900_4 945713.IALB_1464 1.764e-27 125.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity luxD - 3.2.1.4,4.2.99.18 ko:K01179,ko:K06889,ko:K10773,ko:K15853 ko00500,ko01100,ko02020,ko02024,ko03410,map00500,map01100,map02020,map02024,map03410 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko03400 - GH5,GH9 - Abhydrolase_1,Acyl_transf_2,DLH,Hydrolase_4,Peptidase_S9 CMS1_k127_1051900_6 1140.Synpcc7942_0673 5.894e-11 65.0 COG0494@1|root,COG1194@1|root,COG0494@2|Bacteria,COG1194@2|Bacteria,1G1E4@1117|Cyanobacteria,1H4BI@1129|Synechococcus 1117|Cyanobacteria L Adenine glycosylase mutT - 3.6.1.55 ko:K03574,ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD,NUDIX_4 CMS1_k127_1055895_0 1123242.JH636437_gene5951 4.22e-33 136.0 2DSHY@1|root,33G71@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1055895_1 351160.RCIX2695 4.448e-08 58.0 arCOG11653@1|root,arCOG11653@2157|Archaea,2Y5YM@28890|Euryarchaeota 28890|Euryarchaeota - - - - - - - - - - - - - - - CMS1_k127_1055895_2 1379270.AUXF01000001_gene2648 0.0002405 44.0 COG0589@1|root,COG0589@2|Bacteria,1ZTUZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Universal stress protein family - - - - - - - - - - - - Usp CMS1_k127_1059384_0 1144275.COCOR_00586 1.928e-139 459.0 COG2031@1|root,COG2031@2|Bacteria,1MV5A@1224|Proteobacteria,42PE0@68525|delta/epsilon subdivisions,2WITD@28221|Deltaproteobacteria,2YUZH@29|Myxococcales 28221|Deltaproteobacteria I Short chain fatty acid transporter atoE - - ko:K02106 ko02020,map02020 - - - ko00000,ko00001 2.A.73.1 - - SCFA_trans CMS1_k127_1064441_4 1183438.GKIL_0596 1.46e-06 61.0 COG0787@1|root,COG0787@2|Bacteria,1G0IV@1117|Cyanobacteria 1117|Cyanobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N CMS1_k127_1064441_2 502025.Hoch_2302 2.784e-60 222.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,42R48@68525|delta/epsilon subdivisions,2WMAR@28221|Deltaproteobacteria,2YUR9@29|Myxococcales 28221|Deltaproteobacteria E MazG nucleotide pyrophosphohydrolase domain mazG - 3.6.1.9 ko:K02499,ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000,ko03036 - - - MazG CMS1_k127_1064441_3 1379698.RBG1_1C00001G0404 5.141e-17 93.0 2EAFJ@1|root,334IY@2|Bacteria,2NRZR@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF1844) - - - - - - - - - - - - DUF1844 CMS1_k127_1064441_0 1232410.KI421421_gene3677 4.805e-100 340.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,42M7K@68525|delta/epsilon subdivisions,2WKKM@28221|Deltaproteobacteria,43S79@69541|Desulfuromonadales 28221|Deltaproteobacteria J Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM,Methyltransf_25 CMS1_k127_1064441_1 1379698.RBG1_1C00001G0708 6.127e-77 267.0 COG0010@1|root,COG0010@2|Bacteria,2NPGU@2323|unclassified Bacteria 2|Bacteria E Arginase family speB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase CMS1_k127_1064527_0 330214.NIDE3773 1.202e-95 320.0 COG1067@1|root,COG1067@2|Bacteria,3J0X2@40117|Nitrospirae 40117|Nitrospirae O AAA domain - - - - - - - - - - - - AAA_32,Lon_C CMS1_k127_1064527_1 1267535.KB906767_gene5535 4.627e-48 193.0 COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4DC@57723|Acidobacteria 57723|Acidobacteria T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - FHA,GAF_3,SpoIIE CMS1_k127_1064527_2 204669.Acid345_4094 1.095e-34 136.0 COG1834@1|root,COG1834@2|Bacteria,3Y86C@57723|Acidobacteria 57723|Acidobacteria E Amidinotransferase - - 3.5.3.18 ko:K01482 - - - - ko00000,ko01000,ko04147 - - - Amidinotransf CMS1_k127_1066972_2 1144275.COCOR_04763 7.459e-06 53.0 2ANK1@1|root,31DJ4@2|Bacteria,1QAV1@1224|Proteobacteria,435BA@68525|delta/epsilon subdivisions,2WZNP@28221|Deltaproteobacteria,2Z2FG@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_1066972_1 404589.Anae109_2020 4.087e-45 169.0 COG5433@1|root,COG5433@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc CMS1_k127_1066972_0 94624.Bpet4636 2.01e-80 276.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VII1@28216|Betaproteobacteria 28216|Betaproteobacteria L similarity to GP 17427840 - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve_3 CMS1_k127_1066972_3 379066.GAU_3508 2.868e-05 47.0 COG4584@1|root,COG4584@2|Bacteria,1ZV8R@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Integrase core domain - - - - - - - - - - - - rve CMS1_k127_1068984_10 644107.SL1157_0518 0.00055 46.0 2DREZ@1|root,33BFB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1068984_4 756272.Plabr_0719 9.014e-40 157.0 COG2732@1|root,COG2732@2|Bacteria 2|Bacteria K (Barnase) inhibitor - - - ko:K03623 - - - - ko00000 - - - Barstar CMS1_k127_1068984_6 1173024.KI912151_gene2384 9.212e-28 122.0 COG2361@1|root,COG2361@2|Bacteria,1GJKA@1117|Cyanobacteria,1JJ4I@1189|Stigonemataceae 1117|Cyanobacteria S Protein of unknown function DUF86 - - - - - - - - - - - - DUF86 CMS1_k127_1068984_7 379731.PST_1417 2.271e-25 108.0 COG1669@1|root,COG1669@2|Bacteria,1MZSR@1224|Proteobacteria,1SA12@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DNA polymerase beta domain protein region - - - ko:K07075 - - - - ko00000 - - - NTP_transf_2 CMS1_k127_1068984_8 485913.Krac_0257 1.973e-14 82.0 2CSWP@1|root,32SS4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1068984_0 1038869.AXAN01000261_gene1347 1.599e-128 421.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VHER@28216|Betaproteobacteria,1K13F@119060|Burkholderiaceae 28216|Betaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 CMS1_k127_1068984_3 153948.NAL212_2269 2.427e-42 157.0 COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2VU5U@28216|Betaproteobacteria,373FN@32003|Nitrosomonadales 28216|Betaproteobacteria L PFAM Transposase IS3 IS911family - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 CMS1_k127_1068984_1 404589.Anae109_3980 1.978e-45 174.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_5,Phage_integrase CMS1_k127_107095_1 1379698.RBG1_1C00001G0393 3.195e-94 314.0 COG0472@1|root,COG0472@2|Bacteria,2NNQW@2323|unclassified Bacteria 2|Bacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 CMS1_k127_107095_0 1121468.AUBR01000006_gene362 1.087e-100 354.0 COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,42EZQ@68295|Thermoanaerobacterales 186801|Clostridia M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M CMS1_k127_107095_2 935948.KE386493_gene2330 1.378e-74 280.0 COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,42EPV@68295|Thermoanaerobacterales 186801|Clostridia D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE CMS1_k127_1071351_3 573413.Spirs_1890 2.401e-20 94.0 COG0617@1|root,COG1418@1|root,COG0617@2|Bacteria,COG1418@2|Bacteria,2J5ZC@203691|Spirochaetes 203691|Spirochaetes H PolyA polymerase papS - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 CMS1_k127_1071351_0 1519464.HY22_11685 1.691e-67 242.0 COG0142@1|root,COG0142@2|Bacteria,1FDCJ@1090|Chlorobi 1090|Chlorobi H Belongs to the FPP GGPP synthase family - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt CMS1_k127_1071351_2 445972.ANACOL_02996 5.958e-27 125.0 COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,3WJVU@541000|Ruminococcaceae 186801|Clostridia J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS CMS1_k127_1071351_1 644966.Tmar_2339 2.381e-43 165.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,3WCU1@538999|Clostridiales incertae sedis 186801|Clostridia J Arginyl tRNA synthetase N terminal dom argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d CMS1_k127_1082252_4 521011.Mpal_0697 3.201e-05 52.0 arCOG04006@1|root,arCOG04006@2157|Archaea 2157|Archaea C HEAT repeats - - - - - - - - - - - - HEAT_2,HEAT_PBS CMS1_k127_1082252_0 670487.Ocepr_0066 3.022e-37 152.0 COG0758@1|root,COG0758@2|Bacteria,1WI08@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus LU Rossmann fold nucleotide-binding protein involved in DNA uptake dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A,TrmB CMS1_k127_1082252_1 1125863.JAFN01000001_gene527 3.57e-36 149.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Lipid A biosynthesis acyltransferase htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans CMS1_k127_1082252_3 880073.Calab_2775 1.103e-26 112.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.11.1,4.6.1.1 ko:K01768,ko:K12132 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko01001 - - - DUF3467 CMS1_k127_1082252_2 644966.Tmar_0284 3.493e-28 132.0 COG2203@1|root,COG3437@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,24IAZ@186801|Clostridia,3WD9X@538999|Clostridiales incertae sedis 186801|Clostridia T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07710 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_9 CMS1_k127_1084078_2 1173025.GEI7407_0307 1.873e-25 123.0 COG0211@1|root,COG0211@2|Bacteria,1G7RW@1117|Cyanobacteria,1HCCX@1150|Oscillatoriales 1117|Cyanobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 CMS1_k127_1084078_3 525904.Tter_0488 1.629e-18 89.0 COG0261@1|root,COG0261@2|Bacteria,2NPSX@2323|unclassified Bacteria 2|Bacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p CMS1_k127_1084078_0 1379270.AUXF01000006_gene192 7.429e-155 506.0 COG1530@1|root,COG1530@2|Bacteria,1ZSZS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribonuclease E/G family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G CMS1_k127_1084078_1 349161.Dred_2537 7.067e-32 135.0 COG5011@1|root,COG5011@2|Bacteria,1V4D0@1239|Firmicutes,249GU@186801|Clostridia,261TK@186807|Peptococcaceae 186801|Clostridia S protein conserved in bacteria (DUF2344) - - - - - - - - - - - - DUF2344 CMS1_k127_1086351_0 269799.Gmet_0178 7.429e-208 664.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,43UFT@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N CMS1_k127_1086351_1 1122176.KB903550_gene4308 2.073e-96 333.0 COG4784@1|root,COG4784@2|Bacteria,4PM59@976|Bacteroidetes,1J075@117747|Sphingobacteriia 976|Bacteroidetes S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 CMS1_k127_1086351_2 671143.DAMO_2570 2.306e-20 98.0 COG0398@1|root,COG0398@2|Bacteria,2NRVF@2323|unclassified Bacteria 2|Bacteria S SNARE associated Golgi protein yjbF - - - - - - - - - - - SNARE_assoc CMS1_k127_1088662_0 671143.DAMO_2778 1.042e-97 332.0 COG1209@1|root,COG1209@2|Bacteria,2NNTJ@2323|unclassified Bacteria 2|Bacteria M Nucleotidyl transferase rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase CMS1_k127_1088662_2 1519464.HY22_06180 1.266e-38 158.0 COG1646@1|root,COG1646@2|Bacteria,1FEV5@1090|Chlorobi 1090|Chlorobi I PcrB family - - - ko:K07094 - - - - ko00000,ko01000 - - - PcrB CMS1_k127_1088662_1 1329516.JPST01000020_gene2284 6.563e-67 241.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,27B5W@186824|Thermoactinomycetaceae 91061|Bacilli J tRNA synthetases class II (A) alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS1_k127_1089039_0 1379270.AUXF01000005_gene709 7.627e-51 202.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1ZSMY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Competence protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,Lactamase_B CMS1_k127_1089172_2 865937.Gilli_0660 4.314e-38 165.0 COG1402@1|root,COG1402@2|Bacteria 2|Bacteria I creatininase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS1_k127_1089172_0 234267.Acid_1492 4.524e-230 737.0 COG4799@1|root,COG4799@2|Bacteria,3Y3SM@57723|Acidobacteria 57723|Acidobacteria I Carboxyl transferase domain - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans CMS1_k127_1089172_1 861299.J421_3417 4.055e-119 393.0 COG0439@1|root,COG0439@2|Bacteria,1ZTBD@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS1_k127_1093233_0 330214.NIDE4168 5.303e-109 372.0 COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,3J0Y7@40117|Nitrospirae 40117|Nitrospirae P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N CMS1_k127_1093233_4 237368.SCABRO_03012 1.266e-50 187.0 2ANS9@1|root,31DS7@2|Bacteria,2IZX5@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS1_k127_1093233_2 1379698.RBG1_1C00001G0113 4.095e-63 242.0 28MYQ@1|root,2ZB5K@2|Bacteria,2NPC8@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - CMS1_k127_1093233_5 1379698.RBG1_1C00001G0114 7.315e-47 175.0 29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1093233_3 247490.KSU1_B0650 8.633e-63 222.0 28MEN@1|root,2ZASA@2|Bacteria,2IZ1H@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS1_k127_1094735_1 1173028.ANKO01000106_gene330 1.633e-76 266.0 COG1216@1|root,COG1216@2|Bacteria,1G10I@1117|Cyanobacteria,1H8DQ@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 CMS1_k127_1094735_2 1385517.N800_04470 8.431e-67 242.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups epsF GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758 - ko:K19424 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_1094735_0 1385517.N800_04465 4.025e-123 407.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups wcaC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K00754,ko:K13684 - - - - ko00000,ko01000,ko01003 - GT4 - DUF3880,Glyco_trans_1_2,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_1107058_0 204669.Acid345_4392 1.605e-168 557.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria 57723|Acidobacteria KLTU Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40,Pkinase CMS1_k127_1107058_1 667014.Thein_1684 1.372e-35 145.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1 CMS1_k127_1122062_2 243231.GSU0503 1.32e-25 113.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,42V4I@68525|delta/epsilon subdivisions,2WRJJ@28221|Deltaproteobacteria,43V8X@69541|Desulfuromonadales 28221|Deltaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB CMS1_k127_1122062_0 1122221.JHVI01000013_gene2767 9.59e-44 162.0 COG1993@1|root,COG1993@2|Bacteria,1WKB2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 CMS1_k127_1122062_1 571166.KI421509_gene1805 3.563e-33 144.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 CMS1_k127_1123128_0 290397.Adeh_0859 1.931e-102 344.0 COG1403@1|root,COG1403@2|Bacteria,1P9DV@1224|Proteobacteria,432XA@68525|delta/epsilon subdivisions,2WXXR@28221|Deltaproteobacteria 28221|Deltaproteobacteria L HNH nucleases - - - - - - - - - - - - HNH CMS1_k127_1123128_2 1300345.LF41_834 1.772e-41 165.0 COG1858@1|root,COG1858@2|Bacteria,1MWAT@1224|Proteobacteria,1RN8J@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Di-haem cytochrome c peroxidase - - - - - - - - - - - - CCP_MauG CMS1_k127_1123128_1 1300345.LF41_834 2.246e-90 315.0 COG1858@1|root,COG1858@2|Bacteria,1MWAT@1224|Proteobacteria,1RN8J@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Di-haem cytochrome c peroxidase - - - - - - - - - - - - CCP_MauG CMS1_k127_1124240_5 306537.jk0305 2.569e-12 69.0 COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,22KDQ@1653|Corynebacteriaceae 201174|Actinobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C CMS1_k127_1124240_3 1120973.AQXL01000112_gene1049 7.437e-37 148.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4HH2N@91061|Bacilli,278HX@186823|Alicyclobacillaceae 91061|Bacilli I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD CMS1_k127_1124240_2 1125863.JAFN01000001_gene840 2.882e-50 186.0 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,42MJ6@68525|delta/epsilon subdivisions,2WJ67@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB CMS1_k127_1124240_1 1379698.RBG1_1C00001G0842 3.971e-83 294.0 COG1181@1|root,COG1181@2|Bacteria,2NPB2@2323|unclassified Bacteria 2|Bacteria M Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N CMS1_k127_1124240_0 398767.Glov_0404 1.115e-129 449.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g CMS1_k127_1124240_4 1303518.CCALI_01551 2.72e-15 90.0 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity kinB - 2.7.13.3 ko:K11383 ko02020,map02020 M00505 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 4HB_MCP_1,HAMP,HATPase_c,HisKA,KinB_sensor,PAS,PAS_4 CMS1_k127_1128686_1 1379698.RBG1_1C00001G0607 1.677e-112 381.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 CMS1_k127_1128686_0 722419.PH505_ab00840 5.615e-162 543.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RYP9@1236|Gammaproteobacteria,2PZTK@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M ERAP1-like C-terminal domain - - 3.4.11.14,3.4.11.2 ko:K01256,ko:K01263 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 CMS1_k127_1129384_0 1380391.JIAS01000012_gene4447 3.924e-201 631.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,2JPZX@204441|Rhodospirillales 204441|Rhodospirillales S COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn CMS1_k127_1129384_2 1144305.PMI02_02410 1.922e-36 148.0 COG2945@1|root,COG2945@2|Bacteria 2|Bacteria - - - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009111,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0034641,GO:0042365,GO:0042737,GO:0042802,GO:0042803,GO:0042816,GO:0042820,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046483,GO:0046700,GO:0046983,GO:0047411,GO:0071704,GO:0072524,GO:0072526,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.1.29 ko:K07020,ko:K18614 ko00750,ko01120,map00750,map01120 - R01649 RC00300,RC00575 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_5,Abhydrolase_6,LIP,UPF0227 CMS1_k127_1129384_1 1291050.JAGE01000001_gene415 6.279e-94 317.0 COG0330@1|root,COG0330@2|Bacteria,1TRN5@1239|Firmicutes,248UU@186801|Clostridia,3WI4C@541000|Ruminococcaceae 186801|Clostridia O SPFH Band 7 PHB domain protein - - - - - - - - - - - - Band_7 CMS1_k127_1129384_3 644966.Tmar_0389 2.491e-13 70.0 COG4877@1|root,COG4877@2|Bacteria,1VEY1@1239|Firmicutes,24VQC@186801|Clostridia 186801|Clostridia S Protein conserved in bacteria - - - - - - - - - - - - RHH_5 CMS1_k127_113534_4 667014.Thein_0626 2.096e-35 157.0 COG0612@1|root,COG0612@2|Bacteria,2GH66@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_113534_7 349520.PPE_01697 4.894e-21 94.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,26YYQ@186822|Paenibacillaceae 91061|Bacilli K Cold-shock protein cspB - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS1_k127_113534_5 768710.DesyoDRAFT_3228 2.48e-31 127.0 COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,265AD@186807|Peptococcaceae 186801|Clostridia K Probable zinc-ribbon domain - - - - - - - - - - - - zf-trcl CMS1_k127_113534_2 768671.ThimaDRAFT_0787 7.036e-76 276.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WWF8@135613|Chromatiales 135613|Chromatiales F Belongs to the 5'-nucleotidase family - - 3.1.3.5,3.6.1.45 ko:K01081,ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos CMS1_k127_113534_1 1047013.AQSP01000139_gene2416 1.297e-77 283.0 COG1404@1|root,COG1404@2|Bacteria,2NNSK@2323|unclassified Bacteria 2|Bacteria O Subtilase family aprN - - - - - - - - - - - Peptidase_S8 CMS1_k127_113534_3 1094980.Mpsy_1427 1.212e-61 230.0 COG5316@1|root,arCOG03524@2157|Archaea,2XZZZ@28890|Euryarchaeota,2NAFM@224756|Methanomicrobia 224756|Methanomicrobia S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 CMS1_k127_113534_6 1157490.EL26_09360 8.071e-25 110.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,27A9T@186823|Alicyclobacillaceae 91061|Bacilli K Cold-shock protein cspC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS1_k127_113534_0 909663.KI867150_gene269 3.049e-166 545.0 COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2MSEM@213462|Syntrophobacterales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 CMS1_k127_1139660_2 635013.TherJR_1135 9.749e-14 74.0 COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,2494Z@186801|Clostridia,260B2@186807|Peptococcaceae 186801|Clostridia H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15760 Porphobil_deam,Porphobil_deamC CMS1_k127_1139660_3 420324.KI912074_gene5904 2.901e-05 56.0 COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,2U1Y2@28211|Alphaproteobacteria,1JRFR@119045|Methylobacteriaceae 28211|Alphaproteobacteria H Uroporphyrinogen-III synthase HemD hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 CMS1_k127_1139660_0 215803.DB30_8633 6.137e-126 429.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2YTTT@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD CMS1_k127_1139660_1 1415780.JPOG01000001_gene217 3.144e-106 354.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1X3C9@135614|Xanthomonadales 135614|Xanthomonadales H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_1149134_1 1267535.KB906767_gene4686 3.03e-06 57.0 COG1305@1|root,COG1305@2|Bacteria,3Y3A2@57723|Acidobacteria 57723|Acidobacteria E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core CMS1_k127_1149134_0 1267535.KB906767_gene4685 7.426e-53 205.0 COG1305@1|root,COG1305@2|Bacteria,3Y2TK@57723|Acidobacteria,2JHX7@204432|Acidobacteriia 204432|Acidobacteriia E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core CMS1_k127_1150953_3 44060.JODL01000011_gene2063 6.274e-09 58.0 COG0394@1|root,COG0394@2|Bacteria,2IM0Q@201174|Actinobacteria 201174|Actinobacteria T Belongs to the low molecular weight phosphotyrosine protein phosphatase family ptpA - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc CMS1_k127_1150953_2 290397.Adeh_2454 2.006e-26 117.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42UBZ@68525|delta/epsilon subdivisions,2WQ0E@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Belongs to the SUA5 family - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC CMS1_k127_1150953_0 443144.GM21_3522 1.083e-43 171.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2WPG2@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC CMS1_k127_1150953_1 644966.Tmar_1417 6.218e-36 141.0 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,3WCV0@538999|Clostridiales incertae sedis 186801|Clostridia F Phosphoribosylglycinamide synthetase, C domain purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N CMS1_k127_1152761_0 1121468.AUBR01000048_gene1658 3.719e-140 457.0 COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,42FQX@68295|Thermoanaerobacterales 186801|Clostridia E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 CMS1_k127_1152761_1 868595.Desca_2000 1.208e-54 206.0 COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia,26127@186807|Peptococcaceae 186801|Clostridia E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS03525 GHMP_kinases_C,GHMP_kinases_N CMS1_k127_1152761_2 743299.Acife_0866 2.705e-05 47.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1T7TE@1236|Gammaproteobacteria,2NBVD@225057|Acidithiobacillales 225057|Acidithiobacillales E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_1157055_4 1128421.JAGA01000002_gene163 5.542e-24 105.0 COG1063@1|root,COG1063@2|Bacteria,2NPK3@2323|unclassified Bacteria 2|Bacteria E Zinc-binding dehydrogenase tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_1157055_2 928724.SacglDRAFT_03385 7.285e-42 179.0 COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,4DZ4C@85010|Pseudonocardiales 201174|Actinobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C CMS1_k127_1157055_3 1125863.JAFN01000001_gene536 8.673e-34 143.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42UES@68525|delta/epsilon subdivisions,2WQD1@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM glycosyl transferase family 9 - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 CMS1_k127_1157055_0 1379698.RBG1_1C00001G1033 1.091e-181 589.0 COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria 2|Bacteria V ABC transporter msbA - - ko:K02021,ko:K06147,ko:K06148,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran CMS1_k127_1157055_5 583355.Caka_1127 5.7e-24 108.0 2E5IJ@1|root,3309Y@2|Bacteria,46SYV@74201|Verrucomicrobia,3K87A@414999|Opitutae 414999|Opitutae - - - - - - - - - - - - - - - CMS1_k127_1157055_1 290397.Adeh_3566 2.259e-58 207.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2YUGG@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS1_k127_1163638_0 1236542.BALM01000011_gene3910 1.845e-146 481.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,2Q93R@267890|Shewanellaceae 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB CMS1_k127_1163638_5 237368.SCABRO_00861 1.738e-29 132.0 COG3288@1|root,COG3288@2|Bacteria,2J0SW@203682|Planctomycetes 203682|Planctomycetes C COG3288 NAD NADP transhydrogenase alpha subunit - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM CMS1_k127_1163638_1 1313301.AUGC01000012_gene1380 1.364e-120 401.0 COG3288@1|root,COG3288@2|Bacteria,4NGH1@976|Bacteroidetes 976|Bacteroidetes C TIGRFAM NAD(P) transhydrogenase, alpha subunit pntAA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N CMS1_k127_1163638_2 1197477.IA57_09855 1.072e-91 318.0 COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,1HWM1@117743|Flavobacteriia 976|Bacteroidetes M Membrane protein involved in D-alanine export - - - - - - - - - - - - MBOAT CMS1_k127_1163638_4 1298867.AUES01000002_gene1528 8.841e-37 151.0 COG1024@1|root,COG1024@2|Bacteria,1N2V7@1224|Proteobacteria,2U4VQ@28211|Alphaproteobacteria,3JXKI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 CMS1_k127_1163638_6 861299.J421_0060 1.653e-22 113.0 COG1524@1|root,COG1524@2|Bacteria,1ZT33@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest CMS1_k127_1163638_3 1121937.AUHJ01000009_gene1566 1.892e-56 201.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,468KZ@72275|Alteromonadaceae 1236|Gammaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL CMS1_k127_1163638_7 861299.J421_4374 3.358e-05 55.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1ZT3Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes LV DNA restriction-modification system - - - - - - - - - - - - N6_Mtase CMS1_k127_1163880_0 1379270.AUXF01000004_gene3094 7.687e-83 286.0 COG1022@1|root,COG1022@2|Bacteria,1ZT60@142182|Gemmatimonadetes 142182|Gemmatimonadetes I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding CMS1_k127_1164656_0 1379698.RBG1_1C00001G0201 5.418e-111 364.0 COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria 2|Bacteria O ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS1_k127_1164656_1 1379698.RBG1_1C00001G0202 1.433e-95 323.0 COG1721@1|root,COG1721@2|Bacteria,2NP6B@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 CMS1_k127_1164656_2 290397.Adeh_4265 2.049e-22 111.0 COG2304@1|root,COG2304@2|Bacteria,1NX8F@1224|Proteobacteria,430QD@68525|delta/epsilon subdivisions,2WVNR@28221|Deltaproteobacteria,2YW4W@29|Myxococcales 28221|Deltaproteobacteria S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA,VWA_2 CMS1_k127_1174297_4 552811.Dehly_1707 5.055e-30 126.0 COG5658@1|root,COG5658@2|Bacteria,2G714@200795|Chloroflexi,34CN7@301297|Dehalococcoidia 301297|Dehalococcoidia S SdpI/YhfL protein family - - - - - - - - - - - - DUF1648,SdpI CMS1_k127_1174297_5 1123242.JH636436_gene345 1.31e-28 117.0 COG0640@1|root,COG0640@2|Bacteria,2J0HF@203682|Planctomycetes 203682|Planctomycetes K regulatory protein, arsR - - - - - - - - - - - - HTH_5 CMS1_k127_1174297_0 1125863.JAFN01000001_gene1589 2.684e-92 315.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 CMS1_k127_1174297_1 720554.Clocl_0522 3.171e-81 282.0 COG2199@1|root,COG3706@2|Bacteria,1UHZ8@1239|Firmicutes,25E7W@186801|Clostridia,3WGN1@541000|Ruminococcaceae 186801|Clostridia T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF,Response_reg CMS1_k127_1174297_2 1232410.KI421418_gene2385 3.226e-80 306.0 COG0642@1|root,COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2206@2|Bacteria,1NSAV@1224|Proteobacteria,42Z68@68525|delta/epsilon subdivisions,2WURV@28221|Deltaproteobacteria,43U68@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains GAF, HisKA, HATPase_c, GAF, HD-GYP-related - - - - - - - - - - - - GAF_2,HD_5,HisKA CMS1_k127_1174297_3 290397.Adeh_4321 4.269e-49 202.0 COG0642@1|root,COG4936@1|root,COG2205@2|Bacteria,COG4936@2|Bacteria,1NRP8@1224|Proteobacteria,42MZW@68525|delta/epsilon subdivisions,2WIV1@28221|Deltaproteobacteria,2YUVS@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PocR CMS1_k127_11798_1 1379698.RBG1_1C00001G1263 2.694e-95 340.0 COG1404@1|root,COG1404@2|Bacteria,2NNSK@2323|unclassified Bacteria 2|Bacteria O Subtilase family aprN - - - - - - - - - - - Peptidase_S8 CMS1_k127_11798_0 1379698.RBG1_1C00001G0830 1.799e-163 528.0 COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria 2|Bacteria J elongation factor G fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 CMS1_k127_1181391_2 867903.ThesuDRAFT_00016 5.283e-84 288.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,3WCZD@538999|Clostridiales incertae sedis 186801|Clostridia E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 CMS1_k127_1181391_3 1123368.AUIS01000004_gene259 5.545e-84 292.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,2NCI8@225057|Acidithiobacillales 225057|Acidithiobacillales J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans CMS1_k127_1181391_0 1120973.AQXL01000133_gene1776 9.754e-244 772.0 COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,4H9ZS@91061|Bacilli,2783C@186823|Alicyclobacillaceae 91061|Bacilli O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Glyco_hydro_9,Thioredox_DsbH CMS1_k127_1181391_1 1207063.P24_14749 7.573e-107 364.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,2JPEG@204441|Rhodospirillales 204441|Rhodospirillales FL 6-O-methylguanine DNA methyltransferase, DNA binding domain - - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N CMS1_k127_1181391_4 290397.Adeh_0199 5.474e-24 112.0 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2WRHK@28221|Deltaproteobacteria,2Z03M@29|Myxococcales 28221|Deltaproteobacteria S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 CMS1_k127_1181391_6 296587.XP_002500670.1 0.0003243 52.0 COG1304@1|root,KOG0538@2759|Eukaryota,37Q8R@33090|Viridiplantae,34P6J@3041|Chlorophyta 3041|Chlorophyta C FMN-dependent dehydrogenase - - 1.1.3.15 ko:K11517 ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00630,map01100,map01110,map01120,map01130,map01200,map04146 M00532 R00475 RC00042 ko00000,ko00001,ko00002,ko01000 - - - FMN_dh CMS1_k127_1189012_0 1329516.JPST01000005_gene1360 9.604e-107 353.0 COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,4HAFQ@91061|Bacilli,27AX8@186824|Thermoactinomycetaceae 91061|Bacilli E Cys/Met metabolism PLP-dependent enzyme mccB GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008284,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0042127,GO:0043418,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0048518,GO:0048522,GO:0050667,GO:0050789,GO:0050794,GO:0065007,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.4.1.1,4.4.1.2,4.4.1.8 ko:K01760,ko:K17217 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00609 R00782,R01001,R01283,R01286,R02408,R04941 RC00056,RC00069,RC00348,RC00382,RC00487,RC00488,RC00710,RC01245,RC02303,RC02814 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU27250 Cys_Met_Meta_PP CMS1_k127_1189012_2 1449126.JQKL01000019_gene3227 3.794e-60 214.0 COG1666@1|root,COG1666@2|Bacteria,1V3UR@1239|Firmicutes,24HUX@186801|Clostridia 186801|Clostridia S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 CMS1_k127_1189012_5 644282.Deba_0162 3.424e-32 136.0 COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Beta-propeller domains of methanol dehydrogenase type - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase CMS1_k127_1189012_7 59374.Fisuc_2259 7.343e-05 53.0 COG1708@1|root,COG1708@2|Bacteria 2|Bacteria S nucleotidyltransferase activity - - - - - - - - - - - - KNTase_C,NTP_transf_2 CMS1_k127_1189012_3 56780.SYN_00535 2.466e-58 221.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42R4C@68525|delta/epsilon subdivisions,2WKG9@28221|Deltaproteobacteria,2MS0Z@213462|Syntrophobacterales 28221|Deltaproteobacteria S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA CMS1_k127_1189012_4 1123060.JONP01000003_gene350 4.965e-45 185.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,2JQH9@204441|Rhodospirillales 204441|Rhodospirillales H TonB-dependent receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec CMS1_k127_1189012_1 1297570.MESS4_790094 5.053e-88 298.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,43IN0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 CMS1_k127_1189012_6 316274.Haur_1203 1.857e-19 90.0 COG1250@1|root,COG1250@2|Bacteria,2G6EB@200795|Chloroflexi 200795|Chloroflexi C 3-hydroxyacyl-CoA dehydrogenase domain protein - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N CMS1_k127_1210603_2 498761.HM1_0721 3.496e-31 129.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF CMS1_k127_1210603_4 215803.DB30_5454 0.0003207 53.0 COG0760@1|root,COG0760@2|Bacteria,1PX93@1224|Proteobacteria,434DB@68525|delta/epsilon subdivisions,2WYQF@28221|Deltaproteobacteria,2Z0D3@29|Myxococcales 28221|Deltaproteobacteria O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 CMS1_k127_1210603_1 156889.Mmc1_2327 1.204e-41 171.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Peptidylprolyl isomerase surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N,SurA_N_3 CMS1_k127_1210603_0 880072.Desac_2139 4.268e-71 254.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,2MQFD@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA CMS1_k127_1210603_3 1265505.ATUG01000001_gene4334 5.151e-09 68.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,2MJCE@213118|Desulfobacterales 28221|Deltaproteobacteria D PFAM ABC transporter ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran CMS1_k127_1214066_0 1125863.JAFN01000001_gene1462 5.774e-281 878.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS CMS1_k127_1214066_3 1121440.AUMA01000006_gene1551 0.000185 46.0 COG3462@1|root,COG3462@2|Bacteria,1QE33@1224|Proteobacteria,43EKD@68525|delta/epsilon subdivisions,2X0Z4@28221|Deltaproteobacteria,2MDTR@213115|Desulfovibrionales 28221|Deltaproteobacteria S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT CMS1_k127_1214066_1 1300345.LF41_1325 2.945e-10 72.0 COG2931@1|root,COG2931@2|Bacteria,1R30G@1224|Proteobacteria,1T60T@1236|Gammaproteobacteria,1XDH4@135614|Xanthomonadales 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - FG-GAP,HemolysinCabind,VCBS CMS1_k127_1214066_2 1267534.KB906754_gene3745 0.0001453 51.0 COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria,2JJGU@204432|Acidobacteriia 204432|Acidobacteriia S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_1216618_0 1172179.AUKV01000012_gene5292 5.062e-08 56.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria 201174|Actinobacteria Q cytochrome p450 - - - - - - - - - - - - p450 CMS1_k127_1231530_1 1499967.BAYZ01000063_gene6022 1.276e-67 258.0 COG1216@1|root,COG2148@1|root,COG1216@2|Bacteria,COG2148@2|Bacteria,2NP9Z@2323|unclassified Bacteria 2|Bacteria GM Glycosyltransferase like family 2 - - - ko:K03606,ko:K07011 ko05111,map05111 - - - ko00000,ko00001 - - - Bac_transf,CoA_binding_3,Glyco_tranf_2_3,Glycos_transf_2 CMS1_k127_1231530_0 1379698.RBG1_1C00001G0996 3.844e-99 332.0 COG0463@1|root,COG0463@2|Bacteria,2NS3Y@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 dpm1 - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 CMS1_k127_123381_2 1380394.JADL01000008_gene3490 3.288e-08 61.0 COG1177@1|root,COG1177@2|Bacteria,1PMX4@1224|Proteobacteria,2U4IF@28211|Alphaproteobacteria,2JWE8@204441|Rhodospirillales 204441|Rhodospirillales E Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 CMS1_k127_123381_0 521045.Kole_0874 6.334e-59 217.0 COG1175@1|root,COG1175@2|Bacteria,2GC8J@200918|Thermotogae 200918|Thermotogae P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K17242 ko02010,map02010 M00207,M00600 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.39 - - BPD_transp_1 CMS1_k127_123381_1 1379698.RBG1_1C00001G0884 1.671e-43 166.0 COG2182@1|root,COG2182@2|Bacteria 2|Bacteria G maltose binding - - - ko:K02027,ko:K17329 ko02010,map02010 M00207,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.33 - - SBP_bac_1,SBP_bac_8 CMS1_k127_1238317_0 1254432.SCE1572_15575 3.954e-118 398.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,42YQ0@68525|delta/epsilon subdivisions,2WTRV@28221|Deltaproteobacteria,2YUFX@29|Myxococcales 28221|Deltaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - - CMS1_k127_1238839_1 999547.KI421500_gene3534 4.703e-127 426.0 COG0769@1|root,COG0769@2|Bacteria,1R52S@1224|Proteobacteria,2U1XC@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Mur ligase family, glutamate ligase domain - - - - - - - - - - - - Mur_ligase_C,Mur_ligase_M CMS1_k127_1238839_0 1121015.N789_00865 1.479e-278 869.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria 1236|Gammaproteobacteria HJ GNAT family acetyltransferase cphA - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - ATP-grasp_5,CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK CMS1_k127_1243091_1 292459.STH1342 1.023e-95 325.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia 186801|Clostridia L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII CMS1_k127_1243091_4 325452.fgenesh_scip_prom.46568.8076 5.395e-05 56.0 COG3914@1|root,KOG4626@2759|Eukaryota,3Q8CX@4776|Peronosporales 4776|Peronosporales GOT Glycosyl transferase family 41 - - 2.4.1.255 ko:K09667 ko00514,ko04931,map00514,map04931 - R09304,R09676 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003,ko03036 - GT41 - Glyco_transf_41,TPR_1,TPR_11,TPR_2,TPR_8 CMS1_k127_1243091_0 1379698.RBG1_1C00001G0312 2.155e-213 676.0 COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria 2|Bacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K02887,ko:K03628 ko03010,ko03018,map03010,map03018 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind CMS1_k127_1243091_3 697281.Mahau_0239 2.906e-25 106.0 COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,42H2T@68295|Thermoanaerobacterales 186801|Clostridia J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 CMS1_k127_1243091_2 1123288.SOV_3c04300 5.035e-73 256.0 COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,4H271@909932|Negativicutes 909932|Negativicutes S Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - DUF1385 CMS1_k127_1246287_0 195522.BD01_0726 1.107e-15 91.0 COG0515@1|root,COG3889@1|root,arCOG03264@1|root,arCOG01672@2157|Archaea,arCOG03264@2157|Archaea,arCOG03682@2157|Archaea,2Y2TW@28890|Euryarchaeota,243EY@183968|Thermococci 183968|Thermococci E solute binding protein - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 CMS1_k127_1246287_1 1038858.AXBA01000001_gene3235 2.849e-09 68.0 COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,3EYM5@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4131) - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131 CMS1_k127_1247319_0 946362.XP_004997743.1 5.238e-167 554.0 COG2132@1|root,2QR4X@2759|Eukaryota,38BK4@33154|Opisthokonta 33154|Opisthokonta Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_1252148_2 991905.SL003B_3564 1.757e-15 88.0 COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PKD CMS1_k127_1252148_0 1267535.KB906767_gene1290 1.306e-82 289.0 COG0697@1|root,COG0697@2|Bacteria,3Y570@57723|Acidobacteria 57723|Acidobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_1252148_1 1380394.JADL01000003_gene4838 5.907e-41 167.0 COG2208@1|root,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,2VEZQ@28211|Alphaproteobacteria,2JRJA@204441|Rhodospirillales 204441|Rhodospirillales KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,SpoIIE CMS1_k127_1254584_3 395495.Lcho_4124 9.346e-36 148.0 COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,1MYI5@1224|Proteobacteria,2WEWP@28216|Betaproteobacteria 28216|Betaproteobacteria G 6-bladed beta-propeller - - - - - - - - - - - - NHL CMS1_k127_1254584_0 880073.Calab_1263 9.451e-99 366.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_1254584_2 748247.AZKH_0348 9.425e-53 205.0 COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2VNUX@28216|Betaproteobacteria 28216|Betaproteobacteria S NHL repeat - - - - - - - - - - - - NHL CMS1_k127_1254584_4 717231.Flexsi_1991 7.687e-20 99.0 COG3303@1|root,COG3303@2|Bacteria,2GG7G@200930|Deferribacteres 200930|Deferribacteres C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_1254584_6 1096930.L284_23330 1.235e-05 58.0 COG0457@1|root,COG0457@2|Bacteria 1096930.L284_23330|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_1254584_1 404589.Anae109_1840 3.292e-94 331.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 CMS1_k127_1254584_5 479432.Sros_7350 7.76e-07 55.0 COG0457@1|root,COG0457@2|Bacteria,2I0V5@201174|Actinobacteria,4EFNJ@85012|Streptosporangiales 201174|Actinobacteria S TPR repeat - - - - - - - - - - - - TPR_11,TPR_16,TPR_8 CMS1_k127_1254866_1 886293.Sinac_3687 1.024e-101 351.0 COG0840@1|root,COG0840@2|Bacteria,2IXQA@203682|Planctomycetes 203682|Planctomycetes NT Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K02660,ko:K03406 ko02020,ko02025,ko02030,map02020,map02025,map02030 - - - ko00000,ko00001,ko02035,ko02044 - - - Globin,HAMP,MCPsignal,PAS_4 CMS1_k127_1254866_6 886293.Sinac_3686 4.173e-34 141.0 COG2199@1|root,COG3706@2|Bacteria,2J0C7@203682|Planctomycetes 203682|Planctomycetes T response regulator receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg CMS1_k127_1254866_2 351607.Acel_1789 3.477e-93 319.0 COG2201@1|root,COG2201@2|Bacteria,2GMBC@201174|Actinobacteria,4ES6U@85013|Frankiales 201174|Actinobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg CMS1_k127_1254866_4 530564.Psta_3069 7.565e-71 264.0 COG1352@1|root,COG1352@2|Bacteria,2IYFW@203682|Planctomycetes 203682|Planctomycetes NT PFAM MCP methyltransferase CheR-type - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N CMS1_k127_1254866_7 1121877.JQKF01000025_gene849 7.272e-06 54.0 2ANEH@1|root,31DD4@2|Bacteria,2HGZW@201174|Actinobacteria,4CP03@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - CMS1_k127_1254866_3 314271.RB2654_10713 9.364e-81 292.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - An_peroxidase,Cadherin,FG-GAP,Glyco_hydro_26,HemolysinCabind,Integrin_beta,Lipase_GDSL_2 CMS1_k127_1254866_0 1379698.RBG1_1C00001G0054 1.894e-182 578.0 COG2502@1|root,COG2502@2|Bacteria,2NNKP@2323|unclassified Bacteria 2|Bacteria E Aspartate-ammonia ligase asnA GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 - R00483 RC00010 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299 AsnA CMS1_k127_1254866_5 289376.THEYE_A2006 4.048e-61 222.0 COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,3J18S@40117|Nitrospirae 40117|Nitrospirae T HD domain - - - - - - - - - - - - - CMS1_k127_125970_0 1120797.KB908260_gene4073 9.556e-127 447.0 COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae 201174|Actinobacteria K involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein pknK_2 - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - AAA_22,GerE,NB-ARC,Pkinase,TPR_12 CMS1_k127_1264704_1 572547.Amico_0081 1.671e-20 104.0 COG0760@1|root,COG0760@2|Bacteria,3TAT4@508458|Synergistetes 508458|Synergistetes M peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase CMS1_k127_1264704_0 861299.J421_3129 2.162e-31 141.0 COG1259@1|root,COG1259@2|Bacteria,1ZTKW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase CMS1_k127_1264704_2 404589.Anae109_1520 3.014e-19 99.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WP23@28221|Deltaproteobacteria,2Z0GF@29|Myxococcales 28221|Deltaproteobacteria S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily yrdA - - - - - - - - - - - Hexapep CMS1_k127_1266412_0 1123508.JH636447_gene7865 3.098e-37 145.0 2FEMV@1|root,346M7@2|Bacteria,2J3MQ@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS1_k127_1266412_1 1278073.MYSTI_06594 1.38e-23 107.0 COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,42WWI@68525|delta/epsilon subdivisions,2WSR8@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 CMS1_k127_1266412_2 443143.GM18_2800 1.533e-10 62.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42T4I@68525|delta/epsilon subdivisions,2X5P3@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI CMS1_k127_1266427_2 443143.GM18_2800 1.533e-10 62.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42T4I@68525|delta/epsilon subdivisions,2X5P3@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI CMS1_k127_1266427_0 404589.Anae109_3282 1.809e-20 102.0 COG3335@1|root,COG3335@2|Bacteria 2|Bacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_ISAZ013,HTH_32 CMS1_k127_1266427_3 1463934.JOCF01000003_gene2885 3.783e-08 62.0 COG5485@1|root,COG5485@2|Bacteria,2GJYB@201174|Actinobacteria 201174|Actinobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL CMS1_k127_1266427_1 438753.AZC_3801 4.438e-16 86.0 COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - LZ_Tnp_IS481,rve,rve_3 CMS1_k127_1267665_0 105559.Nwat_2093 3.453e-116 391.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB CMS1_k127_1285571_1 204669.Acid345_3489 0.0002224 46.0 COG4758@1|root,COG4758@2|Bacteria,3Y554@57723|Acidobacteria,2JNA4@204432|Acidobacteriia 204432|Acidobacteriia S Cell wall-active antibiotics response 4TMS YvqF - - - - - - - - - - - - DUF2154 CMS1_k127_1285571_0 1379698.RBG1_1C00001G0107 4.335e-51 196.0 COG3170@1|root,COG3170@2|Bacteria,2NPXD@2323|unclassified Bacteria 2|Bacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - CMS1_k127_1289965_1 357808.RoseRS_1236 2.466e-76 265.0 COG1131@1|root,COG1131@2|Bacteria,2G5PC@200795|Chloroflexi,376BU@32061|Chloroflexia 2|Bacteria V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_1289965_3 309801.trd_1502 4.518e-14 85.0 COG5662@1|root,COG5662@2|Bacteria,2G7G7@200795|Chloroflexi,27YCS@189775|Thermomicrobia 189775|Thermomicrobia K AntiSigma factor - - - - - - - - - - - - - CMS1_k127_1289965_2 926569.ANT_02560 1.441e-48 179.0 COG1595@1|root,COG1595@2|Bacteria,2G96E@200795|Chloroflexi 200795|Chloroflexi K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_1289965_0 926550.CLDAP_22570 1.779e-142 462.0 COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi 200795|Chloroflexi K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_RNA_bind CMS1_k127_1290014_5 1423724.BAMM01000003_gene574 0.0009458 48.0 COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,4H9WZ@91061|Bacilli,3F4V1@33958|Lactobacillaceae 91061|Bacilli D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030428,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin CMS1_k127_1290014_1 215803.DB30_7109 1.345e-135 457.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2YTZH@29|Myxococcales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA CMS1_k127_1290014_3 401526.TcarDRAFT_0178 6.076e-10 71.0 COG1589@1|root,COG1589@2|Bacteria,1V57G@1239|Firmicutes,4H4A7@909932|Negativicutes 909932|Negativicutes D cell division protein FtsQ ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 CMS1_k127_1290014_0 1232410.KI421421_gene3865 2.325e-146 479.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,43T1G@69541|Desulfuromonadales 28221|Deltaproteobacteria M UDP-N-acetylmuramate-L-alanine ligase activity murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M CMS1_k127_1290014_2 1379698.RBG1_1C00001G0396 1.156e-80 284.0 COG0707@1|root,COG0707@2|Bacteria,2NP4Z@2323|unclassified Bacteria 2|Bacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227,6.3.2.8 ko:K01924,ko:K02563 ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112 - R03193,R05032,R05662 RC00005,RC00049,RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - GT28 iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089 Glyco_tran_28_C,Glyco_transf_28 CMS1_k127_1290014_4 86416.Clopa_2893 8.631e-09 57.0 COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,36EE6@31979|Clostridiaceae 186801|Clostridia D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE CMS1_k127_1307331_1 631454.N177_3094 1.291e-105 363.0 COG2267@1|root,COG3629@1|root,COG3899@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4 CMS1_k127_1307331_2 1029824.AFID01000011_gene876 1.7e-50 200.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GMPZ@201174|Actinobacteria,1W7XS@1268|Micrococcaceae 201174|Actinobacteria KLT Protein tyrosine kinase pknA - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase CMS1_k127_1307331_6 1291050.JAGE01000001_gene508 8.505e-05 48.0 COG4980@1|root,COG4980@2|Bacteria 2|Bacteria D gas vesicle protein XK27_07760 - - - - - - - - - - - YtxH CMS1_k127_1307331_4 571166.KI421509_gene2530 7.146e-16 93.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the ompA family yiaD - - - - - - - - - - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA CMS1_k127_1307331_3 1242864.D187_004669 2.57e-20 107.0 COG2885@1|root,COG4719@1|root,COG2885@2|Bacteria,COG4719@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3 CMS1_k127_1307331_5 767029.HMPREF9154_3050 1.543e-09 67.0 COG1309@1|root,COG1309@2|Bacteria,2I07A@201174|Actinobacteria,4DW2Y@85009|Propionibacteriales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS1_k127_1307331_0 1121918.ARWE01000001_gene3079 5.367e-196 644.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42P5P@68525|delta/epsilon subdivisions,2WITN@28221|Deltaproteobacteria,43TQJ@69541|Desulfuromonadales 28221|Deltaproteobacteria E HI0933-like protein - - - - - - - - - - - - Fer4,Fer4_20,Fer4_9,Pyr_redox_2 CMS1_k127_1331298_0 1521187.JPIM01000153_gene945 8.7e-139 460.0 COG0448@1|root,COG0448@2|Bacteria,2G66Q@200795|Chloroflexi,374V0@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase CMS1_k127_1331298_1 926550.CLDAP_15250 5.378e-54 198.0 COG0448@1|root,COG0448@2|Bacteria,2G66Q@200795|Chloroflexi 200795|Chloroflexi H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase CMS1_k127_1338583_3 1120919.AUBI01000027_gene3513 0.0004055 49.0 COG4319@1|root,COG4319@2|Bacteria,1NMUI@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440,SnoaL_3 CMS1_k127_1338583_1 349521.HCH_02499 8.348e-89 308.0 COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,1STV6@1236|Gammaproteobacteria,1XQTP@135619|Oceanospirillales 135619|Oceanospirillales S benzoyl-CoA oxygenase - - 1.14.13.208 ko:K15512 ko00362,map00362 - R09555 RC01739 ko00000,ko00001,ko01000 - - - - CMS1_k127_1338583_2 909663.KI867150_gene1782 1.097e-18 92.0 COG0454@1|root,COG0456@2|Bacteria,1RGZ2@1224|Proteobacteria,43B9P@68525|delta/epsilon subdivisions,2X6NT@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_1338583_0 67352.JODS01000003_gene2084 1.636e-119 395.0 COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria 201174|Actinobacteria C Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 CMS1_k127_1338600_1 909663.KI867150_gene1782 3.485e-18 94.0 COG0454@1|root,COG0456@2|Bacteria,1RGZ2@1224|Proteobacteria,43B9P@68525|delta/epsilon subdivisions,2X6NT@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_1338600_0 1449976.KALB_1389 2.488e-120 397.0 COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4DXWC@85010|Pseudonocardiales 201174|Actinobacteria S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 CMS1_k127_1342589_1 1125863.JAFN01000001_gene2287 1.63e-23 105.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU TIGRFAM type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 CMS1_k127_1342589_0 1499967.BAYZ01000074_gene2101 5.327e-28 130.0 COG1807@1|root,COG1807@2|Bacteria,2NP0P@2323|unclassified Bacteria 2|Bacteria M Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723,PMT_2 CMS1_k127_1345715_1 1288826.MSNKSG1_07613 6.179e-06 55.0 COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria,4665P@72275|Alteromonadaceae 1236|Gammaproteobacteria M HlyD family secretion protein - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_3,HlyD_D23,OEP CMS1_k127_1345715_0 1379698.RBG1_1C00001G0616 1.317e-76 262.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - - - - - - - - - - F5_F8_type_C,Peptidase_M6 CMS1_k127_1349630_9 1265505.ATUG01000003_gene860 2.641e-06 51.0 COG0642@1|root,COG2205@2|Bacteria,1R7QH@1224|Proteobacteria,42PSC@68525|delta/epsilon subdivisions,2WKFW@28221|Deltaproteobacteria,2MJNP@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c CMS1_k127_1349630_3 243231.GSU1524 1.844e-63 241.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,43TVI@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS1_k127_1349630_2 671143.DAMO_1380 4.742e-70 259.0 COG0496@1|root,COG0496@2|Bacteria,2NPCG@2323|unclassified Bacteria 2|Bacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - iSFxv_1172.SFxv_3035 SurE CMS1_k127_1349630_5 497964.CfE428DRAFT_4728 5.583e-37 158.0 COG0463@1|root,COG0463@2|Bacteria,46UW3@74201|Verrucomicrobia 74201|Verrucomicrobia M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_1349630_8 925775.XVE_0073 9.395e-09 66.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,1X4IR@135614|Xanthomonadales 135614|Xanthomonadales M Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans CMS1_k127_1349630_6 1254432.SCE1572_46635 8.772e-20 103.0 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,42V1F@68525|delta/epsilon subdivisions,2WR79@28221|Deltaproteobacteria,2Z1R6@29|Myxococcales 28221|Deltaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 CMS1_k127_1349630_1 194439.CT0092 9.956e-88 310.0 COG0240@1|root,COG0240@2|Bacteria,1FDCM@1090|Chlorobi 1090|Chlorobi I NAD-dependent glycerol-3-phosphate dehydrogenase domain protein gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N CMS1_k127_1349630_4 1121468.AUBR01000051_gene1999 4.569e-38 151.0 COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,42GMG@68295|Thermoanaerobacterales 186801|Clostridia I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf CMS1_k127_1349630_0 643648.Slip_1473 1.109e-129 427.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,42JRT@68298|Syntrophomonadaceae 186801|Clostridia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 CMS1_k127_1349630_7 429009.Adeg_1225 1.622e-13 74.0 COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,42EX0@68295|Thermoanaerobacterales 186801|Clostridia C Protein of unknown function (DUF512) - - - - - - - - - - - - DUF512,PDZ CMS1_k127_134986_5 1121035.AUCH01000008_gene1001 1.74e-08 56.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,2KV57@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activ_2 CMS1_k127_134986_1 864051.BurJ1DRAFT_0325 9.301e-130 428.0 COG2270@1|root,COG2270@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K08162,ko:K08226,ko:K16211 - - - - ko00000,ko02000 2.A.1.2.21,2.A.1.41,2.A.2.6 - - MFS_1,PUCC CMS1_k127_134986_2 756272.Plabr_3195 5.446e-100 341.0 COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes 203682|Planctomycetes P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA CMS1_k127_134986_0 1191523.MROS_1006 7.24e-193 627.0 COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria 2|Bacteria T AMP binding ybaT GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169 - ko:K03322,ko:K07076,ko:K09944,ko:K16263 - - - - ko00000,ko02000 2.A.3.13,2.A.55.2.6,2.A.55.3 - - AA_permease_2,Usp CMS1_k127_134986_4 1191523.MROS_1008 4.807e-25 113.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport cmpX - - - - - - - - - - - MS_channel,TM_helix CMS1_k127_134986_3 671143.DAMO_0826 3.48e-95 331.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - ko:K02569,ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT,Cytochrome_C7 CMS1_k127_1357680_6 7719.XP_002122156.1 3.299e-07 59.0 KOG2177@1|root,KOG2177@2759|Eukaryota,38EA3@33154|Opisthokonta,3BFJH@33208|Metazoa,3CRTV@33213|Bilateria,47YXB@7711|Chordata 33208|Metazoa O zinc ion binding - - 2.3.2.27 ko:K11997,ko:K12026,ko:K12035 ko05206,map05206 - - - ko00000,ko00001,ko01000,ko03019,ko04121 - - - DUF3583,NHL,zf-B_box,zf-C3HC4,zf-RING_UBOX CMS1_k127_1357680_3 269799.Gmet_3132 1.838e-52 193.0 COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,42SPV@68525|delta/epsilon subdivisions,2WPTH@28221|Deltaproteobacteria,43SW8@69541|Desulfuromonadales 28221|Deltaproteobacteria P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div CMS1_k127_1357680_1 1379698.RBG1_1C00001G0364 2.073e-123 404.0 COG0306@1|root,COG0306@2|Bacteria,2NP4R@2323|unclassified Bacteria 2|Bacteria P Phosphate transporter family pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 CMS1_k127_1357680_0 1163617.SCD_n02012 1.541e-134 441.0 COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria 28216|Betaproteobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 CMS1_k127_1357680_2 234267.Acid_5036 4.326e-88 319.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process cya3 - - - - - - - - - - - TPR_16,TPR_2,TPR_8,Trans_reg_C CMS1_k127_1357680_4 429009.Adeg_1311 9.376e-51 205.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales 186801|Clostridia KLT Serine threonine protein kinase prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase CMS1_k127_1357680_5 42256.RradSPS_2494 8.139e-13 75.0 COG0589@1|root,COG0589@2|Bacteria,2HR8H@201174|Actinobacteria,4CT4U@84995|Rubrobacteria 84995|Rubrobacteria T COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - - - - - - - - - - Usp CMS1_k127_1357680_7 321327.CYA_2536 7.07e-07 55.0 COG1371@1|root,COG1371@2|Bacteria,1G7JS@1117|Cyanobacteria 1117|Cyanobacteria S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease CMS1_k127_1359517_2 290397.Adeh_0220 2.448e-11 68.0 COG1943@1|root,COG1943@2|Bacteria,1RBFM@1224|Proteobacteria,42QPI@68525|delta/epsilon subdivisions,2WMUC@28221|Deltaproteobacteria,2Z0AC@29|Myxococcales 28221|Deltaproteobacteria L High confidence in function and specificity - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp CMS1_k127_1359517_4 290397.Adeh_3990 3.693e-09 64.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RAB@68525|delta/epsilon subdivisions,2X5MA@28221|Deltaproteobacteria,2Z369@29|Myxococcales 28221|Deltaproteobacteria L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp CMS1_k127_1359517_3 290397.Adeh_1793 2.757e-10 71.0 COG0305@1|root,COG3378@1|root,COG0305@2|Bacteria,COG3378@2|Bacteria,1Q6JX@1224|Proteobacteria,433AP@68525|delta/epsilon subdivisions,2WXA1@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DnaB-like helicase C terminal domain - - - - - - - - - - - - DnaB_C CMS1_k127_1359517_1 290397.Adeh_3789 7.603e-18 85.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2YURT@29|Myxococcales 28221|Deltaproteobacteria M Transglycosylase SLT domain mltD2 - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT CMS1_k127_139128_0 1191523.MROS_1041 8.171e-271 849.0 COG0188@1|root,COG0188@2|Bacteria 2|Bacteria L DNA topoisomerase II activity gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV CMS1_k127_139128_1 379066.GAU_1881 4.524e-61 218.0 COG2344@1|root,COG2344@2|Bacteria,1ZTJV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N CMS1_k127_139128_2 926692.AZYG01000018_gene291 3.77e-44 171.0 COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,3WBNJ@53433|Halanaerobiales 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_1402769_1 1125863.JAFN01000001_gene2283 4.404e-77 279.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Type II and III secretion system protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N CMS1_k127_1402769_4 1121933.AUHH01000022_gene2467 2.349e-19 102.0 COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4DR1Q@85009|Propionibacteriales 201174|Actinobacteria E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI CMS1_k127_1402769_3 1121946.AUAX01000014_gene1079 1.606e-29 132.0 COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4D8ZN@85008|Micromonosporales 201174|Actinobacteria L Methyltransferase rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 CMS1_k127_1402769_2 1123053.AUDG01000034_gene764 1.229e-42 172.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1WY42@135613|Chromatiales 135613|Chromatiales H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like CMS1_k127_1402769_0 429009.Adeg_1380 2.436e-81 287.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales 186801|Clostridia E PFAM aminotransferase, class I aspB - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS06550 Aminotran_1_2 CMS1_k127_1406574_1 1356854.N007_11430 5.602e-78 279.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,278UP@186823|Alicyclobacillaceae 91061|Bacilli NU type II secretion system protein E pilB - - ko:K02243,ko:K02652 - M00429 - - ko00000,ko00002,ko02035,ko02044 3.A.14.1,3.A.15.2 - - T2SSE,T2SSE_N CMS1_k127_1406574_0 269799.Gmet_1939 4.216e-98 327.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,43UES@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran CMS1_k127_1410933_0 309803.CTN_0446 1.925e-60 219.0 COG0448@1|root,COG0448@2|Bacteria,2GC69@200918|Thermotogae 200918|Thermotogae F Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase CMS1_k127_1410933_1 945713.IALB_2930 1.284e-56 212.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - CMS1_k127_1412174_2 861299.J421_5846 3.682e-09 67.0 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS1_k127_1412174_0 479432.Sros_1916 9.401e-79 279.0 COG0778@1|root,COG0778@2|Bacteria,2GPB4@201174|Actinobacteria,4EPBI@85012|Streptosporangiales 201174|Actinobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase CMS1_k127_1412174_1 287.DR97_109 1.016e-37 147.0 COG2885@1|root,COG3047@1|root,COG2885@2|Bacteria,COG3047@2|Bacteria,1R4WG@1224|Proteobacteria,1T1FC@1236|Gammaproteobacteria,1YKUX@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M OprF membrane domain oprF - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,OprF,TSP_3 CMS1_k127_1417532_0 290397.Adeh_3188 2.747e-119 403.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - ko:K07004,ko:K09955 - - - - ko00000 - - - Big_4,FTP,Laminin_G_3,PA,Peptidase_M36 CMS1_k127_1417532_3 1191523.MROS_1825 1.639e-11 77.0 COG4412@1|root,COG4447@1|root,COG4412@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - DUF4859,FlgD_ig,PSII_BNR CMS1_k127_1417532_1 234267.Acid_1085 2.01e-89 306.0 COG0123@1|root,COG0123@2|Bacteria,3Y46F@57723|Acidobacteria 57723|Acidobacteria BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl CMS1_k127_1417532_4 1306174.JODP01000001_gene4626 6.787e-06 56.0 COG5180@1|root,COG5180@2|Bacteria,2GKJ7@201174|Actinobacteria 201174|Actinobacteria A pathogenesis - - - - - - - - - - - - GPDPase_memb CMS1_k127_1428485_0 1144275.COCOR_01346 1.507e-22 100.0 COG0848@1|root,COG0848@2|Bacteria,1Q1RQ@1224|Proteobacteria,437EZ@68525|delta/epsilon subdivisions,2X2MA@28221|Deltaproteobacteria,2Z03D@29|Myxococcales 28221|Deltaproteobacteria U Biopolymer transport protein - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD CMS1_k127_1428485_1 67315.JOBD01000016_gene6458 5.779e-06 59.0 COG2340@1|root,COG2340@2|Bacteria,2GM57@201174|Actinobacteria 201174|Actinobacteria T protein with SCP PR1 domains - - - - - - - - - - - - CAP CMS1_k127_1441374_0 504472.Slin_1834 1.701e-312 985.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,47K02@768503|Cytophagia 976|Bacteroidetes S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_1441374_1 1458357.BG58_24530 5.042e-101 336.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,1K52I@119060|Burkholderiaceae 28216|Betaproteobacteria S Methyltransferase egtD - - - - - - - - - - - Methyltransf_33 CMS1_k127_144420_0 290397.Adeh_0386 8.299e-103 347.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS1_k127_144420_1 710111.FraQA3DRAFT_5053 2.066e-13 81.0 COG1409@1|root,COG1409@2|Bacteria,2GP0C@201174|Actinobacteria,4EX0J@85013|Frankiales 201174|Actinobacteria S Purple acid Phosphatase, N-terminal domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Metallophos,Pur_ac_phosph_N CMS1_k127_1454565_1 553204.CORAM0001_1623 7.295e-45 184.0 COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,22K42@1653|Corynebacteriaceae 201174|Actinobacteria KLT serine threonine protein kinase pknA GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0040007,GO:0042304,GO:0043085,GO:0043086,GO:0043170,GO:0043388,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051055,GO:0051098,GO:0051099,GO:0051101,GO:0051128,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1454565_0 314230.DSM3645_28187 1.294e-114 381.0 COG5659@1|root,COG5659@2|Bacteria,2IWRG@203682|Planctomycetes 203682|Planctomycetes L best DB hits BLAST gb AAD45539.1 - - - - - - - - - - - - DDE_5 CMS1_k127_148061_4 1379698.RBG1_1C00001G1760 3.767e-92 313.0 COG1030@1|root,COG1030@2|Bacteria,2NNMU@2323|unclassified Bacteria 2|Bacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD CMS1_k127_148061_2 706587.Desti_1112 4.585e-107 352.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2MQ9P@213462|Syntrophobacterales 28221|Deltaproteobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7 CMS1_k127_148061_1 1297742.A176_00305 9.618e-124 435.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,2YTYX@29|Myxococcales 28221|Deltaproteobacteria C dihydrolipoamide dehydrogenase lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim CMS1_k127_148061_3 266117.Rxyl_2548 4.838e-102 345.0 COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,4CPF1@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM CMS1_k127_148061_0 290397.Adeh_3944 3.091e-180 573.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2YWVA@29|Myxococcales 28221|Deltaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N CMS1_k127_151211_0 1379698.RBG1_1C00001G0607 8.028e-130 441.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 CMS1_k127_1518855_1 648996.Theam_1729 4.762e-103 347.0 COG0809@1|root,COG0809@2|Bacteria,2G3KG@200783|Aquificae 200783|Aquificae J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth CMS1_k127_1518855_0 640081.Dsui_0484 2.676e-128 417.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,2KUCP@206389|Rhodocyclales 206389|Rhodocyclales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N CMS1_k127_155843_0 204669.Acid345_0942 1.994e-07 54.0 COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia 2|Bacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_1572743_1 309807.SRU_0592 2.254e-37 153.0 COG1596@1|root,COG1596@2|Bacteria,4NEXJ@976|Bacteroidetes,1FIJ9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Polysaccharide biosynthesis/export protein - - - - - - - - - - - - Poly_export,SLBB CMS1_k127_1572743_0 330214.NIDE0885 7.027e-54 197.0 COG0399@1|root,COG0399@2|Bacteria,3J09X@40117|Nitrospirae 2|Bacteria E Belongs to the DegT DnrJ EryC1 family spsC - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 CMS1_k127_1585519_2 635013.TherJR_1119 0.0001383 51.0 COG3005@1|root,COG3005@2|Bacteria,1VW0I@1239|Firmicutes,250P8@186801|Clostridia 186801|Clostridia C TIGRFAM cytochrome C family protein - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_1585519_0 234267.Acid_4736 2.781e-71 262.0 COG0457@1|root,COG0457@2|Bacteria,3Y3RA@57723|Acidobacteria 57723|Acidobacteria M SMART Tetratricopeptide - - - - - - - - - - - - PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 CMS1_k127_1585519_1 439235.Dalk_2217 8.49e-57 212.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales 28221|Deltaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 CMS1_k127_1595261_3 404589.Anae109_4242 1.105e-53 200.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales 28221|Deltaproteobacteria K ATPase associated with various cellular activities, AAA_5 - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat CMS1_k127_1595261_2 349161.Dred_1767 4.417e-54 196.0 COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia 186801|Clostridia H ATP corrinoid adenosyltransferase BtuR CobO CobP - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR CMS1_k127_1595261_1 1121468.AUBR01000034_gene1359 2.677e-73 259.0 COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,24944@186801|Clostridia,42EUB@68295|Thermoanaerobacterales 186801|Clostridia E LAO AO transport system ATPase - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK CMS1_k127_1595261_0 215803.DB30_0533 1.656e-229 722.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2YU4T@29|Myxococcales 28221|Deltaproteobacteria I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase CMS1_k127_1603234_4 1114959.SZMC14600_11438 0.0002033 46.0 COG1028@1|root,COG1028@2|Bacteria,2GJIH@201174|Actinobacteria,4DXXW@85010|Pseudonocardiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase bdhA - 1.1.1.30 ko:K00019 ko00072,ko00650,ko01100,map00072,map00650,map01100 M00088 R01361 RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 CMS1_k127_1603234_3 1192034.CAP_0944 2.736e-35 141.0 COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,434U0@68525|delta/epsilon subdivisions,2WZ4Y@28221|Deltaproteobacteria,2Z1C7@29|Myxococcales 28221|Deltaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP CMS1_k127_1603234_1 1254432.SCE1572_12185 1.075e-78 271.0 COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,42QU2@68525|delta/epsilon subdivisions,2WMSF@28221|Deltaproteobacteria,2YYYW@29|Myxococcales 28221|Deltaproteobacteria I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 CMS1_k127_1603234_0 29581.BW37_02150 2.301e-98 346.0 COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2VIAN@28216|Betaproteobacteria,475YD@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain abmD - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_1603234_2 1411123.JQNH01000001_gene266 1.155e-46 188.0 COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NADH flavin oxidoreductase NADH oxidase - - 1.14.13.40 ko:K09461 ko00627,ko01120,map00627,map01120 - R03998,R03999 RC00244 ko00000,ko00001,ko01000 - - - FAD_binding_3,Oxidored_FMN CMS1_k127_16054_5 1191523.MROS_1540 2.666e-09 71.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8,SLH CMS1_k127_16054_2 523791.Kkor_1008 9.445e-38 164.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1S07F@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase - - - ko:K04753 - - - - ko00000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_16054_0 485916.Dtox_1611 5.266e-106 356.0 COG0535@1|root,COG0535@2|Bacteria,1URM8@1239|Firmicutes,24XB8@186801|Clostridia 186801|Clostridia C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM CMS1_k127_16054_4 443143.GM18_2715 4.239e-28 117.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM Cold-shock protein, DNA-binding - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS1_k127_16054_3 945713.IALB_0238 1.495e-35 138.0 COG4274@1|root,COG4274@2|Bacteria 2|Bacteria S GYD domain - - - - - - - - - - - - GYD CMS1_k127_16054_1 309807.SRU_1244 1.826e-92 326.0 COG0612@1|root,COG0612@2|Bacteria,4PICD@976|Bacteroidetes,1FJRH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_16111_1 404589.Anae109_2038 1.844e-20 94.0 COG1970@1|root,COG1970@2|Bacteria 2|Bacteria M mechanosensitive ion channel activity mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL CMS1_k127_16111_0 760568.Desku_1070 2.241e-159 520.0 COG1067@1|root,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,260R2@186807|Peptococcaceae 186801|Clostridia O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C CMS1_k127_1617441_2 502025.Hoch_3692 8.607e-16 89.0 COG0354@1|root,COG0354@2|Bacteria,1QYGE@1224|Proteobacteria,43CCJ@68525|delta/epsilon subdivisions,2WYDB@28221|Deltaproteobacteria,2Z3H2@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the GcvT family ygfZ - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C CMS1_k127_1617441_1 290397.Adeh_1024 5.05e-34 134.0 COG0640@1|root,COG0640@2|Bacteria,1N7I7@1224|Proteobacteria,42VTU@68525|delta/epsilon subdivisions,2WRGJ@28221|Deltaproteobacteria,2YVHK@29|Myxococcales 28221|Deltaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 CMS1_k127_1617441_0 552811.Dehly_1422 4.835e-77 274.0 COG0500@1|root,COG2226@2|Bacteria,2G6GD@200795|Chloroflexi,34CS0@301297|Dehalococcoidia 301297|Dehalococcoidia Q Ribosomal protein L11 methyltransferase (PrmA) - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 CMS1_k127_1617441_3 518766.Rmar_0813 1.171e-06 52.0 COG0503@1|root,COG0503@2|Bacteria,4NP7K@976|Bacteroidetes 976|Bacteroidetes F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran CMS1_k127_1618165_1 1145276.T479_11595 2.93e-06 54.0 COG4244@1|root,COG4244@2|Bacteria,1UMQ2@1239|Firmicutes,4ITYP@91061|Bacilli 91061|Bacilli S Membrane - - - - - - - - - - - - - CMS1_k127_1618165_0 574087.Acear_0203 4.155e-118 406.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TQJM@1239|Firmicutes,24CFC@186801|Clostridia 186801|Clostridia C TIGRFAM glycerol-3-phosphate dehydrogenase, anaerobic, C subunit glpC - 1.1.5.3 ko:K00113 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - CCG,Fer4_8 CMS1_k127_162419_3 1123508.JH636453_gene5802 5.532e-51 206.0 COG3210@1|root,COG3391@1|root,COG3827@1|root,COG4932@1|root,COG3210@2|Bacteria,COG3391@2|Bacteria,COG3827@2|Bacteria,COG4932@2|Bacteria,2IY8U@203682|Planctomycetes 203682|Planctomycetes M Integrin alpha (beta-propellor repeats). - - - - - - - - - - - - VCBS CMS1_k127_162419_5 459349.CLOAM0891 2.118e-07 64.0 COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Big_2,HATPase_c,PQQ_2,PQQ_3,Peptidase_C25,SLH,Y_Y_Y CMS1_k127_162419_2 235909.GK1588 7.154e-56 223.0 COG3342@1|root,COG3342@2|Bacteria,1TS8U@1239|Firmicutes,4HBYK@91061|Bacilli,1WG5D@129337|Geobacillus 91061|Bacilli S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028,PG_binding_2 CMS1_k127_162419_1 1120972.AUMH01000013_gene2477 3.841e-60 221.0 COG3342@1|root,COG3342@2|Bacteria,1TS8U@1239|Firmicutes,4HBYK@91061|Bacilli,279NH@186823|Alicyclobacillaceae 91061|Bacilli S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028,PG_binding_2 CMS1_k127_162419_7 644282.Deba_2892 1.023e-05 57.0 COG0457@1|root,COG0501@1|root,COG0457@2|Bacteria,COG0501@2|Bacteria,1R5A7@1224|Proteobacteria,42MP6@68525|delta/epsilon subdivisions,2WK92@28221|Deltaproteobacteria 28221|Deltaproteobacteria O peptidase M48, Ste24p - - - - - - - - - - - - Peptidase_M48,TPR_11,TPR_17 CMS1_k127_162419_0 1379698.RBG1_1C00001G0618 2.306e-153 509.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NNS9@2323|unclassified Bacteria 2|Bacteria EU peptidase S9 prolyl oligopeptidase active site yuxL - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 CMS1_k127_162419_4 1449080.JQMV01000003_gene912 1.674e-33 150.0 COG4221@1|root,COG4221@2|Bacteria,1WIDQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short CMS1_k127_162419_6 383372.Rcas_1198 3.102e-07 57.0 COG1752@1|root,COG1752@2|Bacteria,2G7GM@200795|Chloroflexi,374ZF@32061|Chloroflexia 32061|Chloroflexia S PFAM Patatin - - - - - - - - - - - - Patatin CMS1_k127_1629352_0 1379698.RBG1_1C00001G0797 8.148e-96 333.0 COG4191@1|root,COG4191@2|Bacteria,2NS4C@2323|unclassified Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg CMS1_k127_165328_1 945713.IALB_0238 3.538e-35 138.0 COG4274@1|root,COG4274@2|Bacteria 2|Bacteria S GYD domain - - - - - - - - - - - - GYD CMS1_k127_165328_0 309807.SRU_1244 2.529e-121 410.0 COG0612@1|root,COG0612@2|Bacteria,4PICD@976|Bacteroidetes,1FJRH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_165328_2 1173264.KI913949_gene14 1.243e-21 100.0 COG0612@1|root,COG0612@2|Bacteria,1G303@1117|Cyanobacteria,1H8AE@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Peptidase M16 inactive domain ymxG - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_1656698_0 392500.Swoo_0198 5.551e-26 120.0 COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,2QAGA@267890|Shewanellaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS CMS1_k127_1656698_3 455632.SGR_4217 1.577e-08 66.0 COG3210@1|root,COG3210@2|Bacteria,2I9GH@201174|Actinobacteria 201174|Actinobacteria U domain, Protein - - - - - - - - - - - - - CMS1_k127_1656698_1 404589.Anae109_2321 3.718e-23 104.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RAB@68525|delta/epsilon subdivisions,2X5MA@28221|Deltaproteobacteria,2Z369@29|Myxococcales 28221|Deltaproteobacteria L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp CMS1_k127_1656698_2 404589.Anae109_2323 6.441e-21 97.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RAB@68525|delta/epsilon subdivisions 1224|Proteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp CMS1_k127_1656698_4 1415780.JPOG01000001_gene1080 0.0002938 48.0 COG1288@1|root,COG1288@2|Bacteria,1MY1J@1224|Proteobacteria,1RS2M@1236|Gammaproteobacteria 1236|Gammaproteobacteria S C4-dicarboxylate anaerobic - - - - - - - - - - - - DcuC CMS1_k127_1658995_3 765912.Thimo_1431 1.789e-36 153.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXP0@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_1658995_0 292459.STH976 1.495e-81 279.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia 186801|Clostridia V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_1658995_2 565045.NOR51B_2004 3.147e-58 218.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1J5K7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion macA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_1658995_1 1379698.RBG1_1C00001G0616 7.734e-78 265.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - - - - - - - - - - F5_F8_type_C,Peptidase_M6 CMS1_k127_1667272_1 370438.PTH_2736 2.706e-127 430.0 COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,260I5@186807|Peptococcaceae 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N CMS1_k127_1667272_6 459349.CLOAM0933 1.863e-08 59.0 COG0268@1|root,COG0268@2|Bacteria 2|Bacteria J rRNA binding rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p CMS1_k127_1667272_0 316067.Geob_2401 1.344e-194 625.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,43TSA@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit CMS1_k127_1667272_4 1385515.N791_03140 3.23e-29 127.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1X4Q0@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N CMS1_k127_1667272_2 237368.SCABRO_00959 3.108e-73 258.0 COG0329@1|root,COG0329@2|Bacteria,2IXII@203682|Planctomycetes 203682|Planctomycetes E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS CMS1_k127_1667272_5 324925.Ppha_0329 2.423e-11 77.0 COG2372@1|root,COG2372@2|Bacteria,1FE0C@1090|Chlorobi 1090|Chlorobi S Bacterial Ig-like domain - - - - - - - - - - - - Big_5 CMS1_k127_1667272_3 103690.17134045 2.546e-59 213.0 COG0078@1|root,COG0078@2|Bacteria,1G068@1117|Cyanobacteria,1HIUZ@1161|Nostocales 1117|Cyanobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS1_k127_1672149_0 880073.Calab_3483 2.616e-106 355.0 COG3033@1|root,COG3033@2|Bacteria,2NNZV@2323|unclassified Bacteria 2|Bacteria E Beta-eliminating lyase tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS1_k127_1672149_1 118163.Ple7327_1970 9.381e-17 90.0 COG2202@1|root,COG3829@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3VMAA@52604|Pleurocapsales 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_9 CMS1_k127_168040_0 765869.BDW_06795 5.967e-132 431.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2MSMB@213481|Bdellovibrionales,2WM0B@28221|Deltaproteobacteria 213481|Bdellovibrionales I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_1688926_3 888062.HMPREF9083_1195 0.0001734 48.0 COG4968@1|root,COG4968@2|Bacteria,1VD7G@1239|Firmicutes,4H9AT@909932|Negativicutes 909932|Negativicutes U Pfam:N_methyl_2 - - - - - - - - - - - - N_methyl,T2SSG CMS1_k127_1688926_0 391625.PPSIR1_04123 4.142e-71 255.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NSM@68525|delta/epsilon subdivisions,2WJXQ@28221|Deltaproteobacteria,2YXY8@29|Myxococcales 28221|Deltaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system pilH - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_1688926_1 321327.CYA_0649 7.19e-31 140.0 COG1277@1|root,COG1277@2|Bacteria,1G09F@1117|Cyanobacteria,1H0C8@1129|Synechococcus 1117|Cyanobacteria S ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_2 CMS1_k127_1688926_2 330214.NIDE3436 1.158e-15 89.0 COG0457@1|root,COG0457@2|Bacteria 330214.NIDE3436|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_1705823_1 237368.SCABRO_01223 2.381e-41 167.0 COG0737@1|root,COG0737@2|Bacteria,2IXWK@203682|Planctomycetes 203682|Planctomycetes C 5'-nucleotidase - - - - - - - - - - - - Cytochrome_C554 CMS1_k127_1705823_2 315730.BcerKBAB4_2184 2.994e-24 105.0 COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,4HKF2@91061|Bacilli,1ZHUS@1386|Bacillus 91061|Bacilli L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupA - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS1_k127_1705823_0 1379698.RBG1_1C00001G0864 3.343e-108 382.0 COG1452@1|root,COG1452@2|Bacteria,2NPN2@2323|unclassified Bacteria 2|Bacteria M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - ko:K04744,ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - LptC,OstA,OstA_C CMS1_k127_1733504_2 1267533.KB906742_gene675 5.223e-24 105.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria 57723|Acidobacteria K Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_1733504_0 1297863.APJF01000010_gene3240 2.906e-294 997.0 COG4625@1|root,COG4625@2|Bacteria,1N4H5@1224|Proteobacteria,2TT5A@28211|Alphaproteobacteria,3JUS8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Autotransporter beta-domain - - - - - - - - - - - - Autotransporter CMS1_k127_1733504_1 1356852.N008_10035 8.702e-26 114.0 COG0664@1|root,COG0664@2|Bacteria,4NFB1@976|Bacteroidetes,47JY7@768503|Cytophagia 976|Bacteroidetes K Transcriptional regulator, Crp Fnr family - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding CMS1_k127_1737836_0 388051.AUFE01000004_gene860 1.335e-146 478.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1K375@119060|Burkholderiaceae 28216|Betaproteobacteria T response regulator zraR - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_1737836_1 1185876.BN8_06217 2.078e-94 330.0 COG4784@1|root,COG4784@2|Bacteria,4PM59@976|Bacteroidetes,47MK2@768503|Cytophagia 976|Bacteroidetes S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 CMS1_k127_1778049_1 649639.Bcell_3975 1.476e-57 213.0 COG2162@1|root,COG2162@2|Bacteria,1VR6B@1239|Firmicutes,4HTTU@91061|Bacilli,1ZG4J@1386|Bacillus 91061|Bacilli Q N-acetyltransferase - - - - - - - - - - - - Acetyltransf_2 CMS1_k127_1778049_0 1047013.AQSP01000134_gene1338 3.664e-114 378.0 COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria 2|Bacteria H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB CMS1_k127_1807364_1 1246484.D479_03072 4.111e-50 186.0 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,3NDE2@45667|Halobacillus 91061|Bacilli L TatD related DNase tatD GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase CMS1_k127_1807364_0 479434.Sthe_0837 1.145e-50 192.0 COG0030@1|root,COG0030@2|Bacteria,2G6DA@200795|Chloroflexi,27XUP@189775|Thermomicrobia 189775|Thermomicrobia J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD CMS1_k127_1810948_1 56780.SYN_00856 1.163e-64 229.0 COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42MRD@68525|delta/epsilon subdivisions,2X5MW@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyl transferase family 21 - - - - - - - - - - - - Glyco_tranf_2_3 CMS1_k127_1810948_0 1193181.BN10_50002 2.975e-65 243.0 COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria 201174|Actinobacteria M PFAM peptidase M6, immune inhibitor A - - - - - - - - - - - - Peptidase_M6 CMS1_k127_1811341_0 880073.Calab_3591 2.096e-125 417.0 COG0180@1|root,COG0180@2|Bacteria,2NNQX@2323|unclassified Bacteria 2|Bacteria J tRNA synthetases class I (W and Y) trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b CMS1_k127_1811341_1 643562.Daes_2473 3.466e-36 142.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,42STM@68525|delta/epsilon subdivisions,2WPAD@28221|Deltaproteobacteria,2MB8X@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM peptidase M50 - - - - - - - - - - - - Peptidase_M50 CMS1_k127_1812454_2 272123.Anacy_5220 4.377e-12 75.0 COG2931@1|root,COG4625@1|root,COG2931@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis - - 3.2.1.4 ko:K01179,ko:K07004 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Calx-beta,Laminin_G_3,PATR CMS1_k127_1812454_3 861299.J421_1299 0.0004635 51.0 2FK3G@1|root,34BRK@2|Bacteria,1ZU1V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl CMS1_k127_1812454_1 880073.Calab_1120 2.556e-25 119.0 COG3358@1|root,COG3358@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1684) - - - ko:K09164 - - - - ko00000 - - - DUF1684 CMS1_k127_1812454_0 552811.Dehly_0286 4.578e-95 319.0 COG2309@1|root,COG2309@2|Bacteria,2G5TH@200795|Chloroflexi,34CT4@301297|Dehalococcoidia 301297|Dehalococcoidia E Thermophilic metalloprotease (M29) - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 CMS1_k127_1825648_8 1123368.AUIS01000001_gene2032 8.249e-54 207.0 COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,1S3EY@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Squalene/phytoene synthase - - - - - - - - - - - - SQS_PSY CMS1_k127_1825648_6 713586.KB900536_gene578 1.55e-61 227.0 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,1RNRI@1236|Gammaproteobacteria,1WYA5@135613|Chromatiales 135613|Chromatiales I Squalene phytoene synthase - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY CMS1_k127_1825648_10 1123368.AUIS01000001_gene2030 2.792e-46 186.0 COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,1SI1R@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase CMS1_k127_1825648_4 1254432.SCE1572_23620 1.751e-64 248.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,2YURG@29|Myxococcales 28221|Deltaproteobacteria L A G-specific mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 CMS1_k127_1825648_3 1089550.ATTH01000001_gene449 2.513e-74 279.0 COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,4NTWX@976|Bacteroidetes 976|Bacteroidetes O Peptidase, S8 S53 family - - - - - - - - - - - - Peptidase_S8 CMS1_k127_1825648_13 880073.Calab_3215 1.234e-19 105.0 COG0366@1|root,COG0708@1|root,COG0366@2|Bacteria,COG0708@2|Bacteria,2NREA@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolase family 70 - - 3.1.11.2,3.2.1.1 ko:K01142,ko:K01176 ko00500,ko01100,ko03410,ko04973,map00500,map01100,map03410,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000,ko03400 - GH13 - Alpha-amylase,CBM_25,DUF1939,He_PIG CMS1_k127_1825648_12 471853.Bcav_2278 2.72e-20 98.0 COG0454@1|root,COG0456@2|Bacteria,2GY1D@201174|Actinobacteria 201174|Actinobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_1825648_11 880073.Calab_3335 3.086e-31 136.0 COG0492@1|root,COG0492@2|Bacteria 2|Bacteria C ferredoxin-NADP+ reductase activity - - - - - - - - - - - - FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding CMS1_k127_1825648_2 161528.ED21_23741 4.099e-92 322.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PR9I@1224|Proteobacteria,2U1SM@28211|Alphaproteobacteria,2K253@204457|Sphingomonadales 204457|Sphingomonadales C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_4,Pyr_redox_3 CMS1_k127_1825648_0 290397.Adeh_2666 1.562e-104 361.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,4397N@68525|delta/epsilon subdivisions,2X4EI@28221|Deltaproteobacteria,2YYVA@29|Myxococcales 28221|Deltaproteobacteria C heat shock protein binding - - - - - - - - - - - - Cytochrome_C7 CMS1_k127_1825648_1 945713.IALB_0802 2.277e-103 372.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - - CMS1_k127_1825648_15 880073.Calab_3331 5.19e-09 69.0 2919D@1|root,2ZNWG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1825648_9 379066.GAU_2304 8.748e-53 201.0 COG3595@1|root,COG3595@2|Bacteria,1ZTJA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative adhesin - - - - - - - - - - - - DUF4097 CMS1_k127_1825648_7 517418.Ctha_0236 1.146e-55 219.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family cspBA - - - - - - - - - - - Peptidase_S8 CMS1_k127_1825648_14 880073.Calab_2081 1.701e-13 84.0 COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria 2|Bacteria P LVIVD repeat - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - LVIVD CMS1_k127_1825648_5 224324.aq_940 1.726e-63 235.0 COG0065@1|root,COG0065@2|Bacteria,2G3S3@200783|Aquificae 200783|Aquificae H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase CMS1_k127_1826907_1 1303692.SFUL_6854 3.4e-05 54.0 COG3307@1|root,COG3307@2|Bacteria,2GP2Y@201174|Actinobacteria 201174|Actinobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C CMS1_k127_1826907_0 323848.Nmul_A0278 2.275e-20 105.0 COG1807@1|root,COG1807@2|Bacteria,1RM6R@1224|Proteobacteria,2VVZK@28216|Betaproteobacteria,372N5@32003|Nitrosomonadales 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 CMS1_k127_1834029_7 1442599.JAAN01000011_gene373 7.999e-06 57.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1X3SF@135614|Xanthomonadales 135614|Xanthomonadales U Type II secretory pathway, component HofQ pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N CMS1_k127_1834029_2 1340493.JNIF01000003_gene2310 7.508e-28 120.0 COG3293@1|root,COG3293@2|Bacteria,3Y7X8@57723|Acidobacteria 57723|Acidobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 CMS1_k127_1834029_1 498211.CJA_0333 4.868e-48 178.0 COG3293@1|root,COG3293@2|Bacteria,1N5YJ@1224|Proteobacteria,1S5EG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DUF4096 CMS1_k127_1834029_3 1214065.BAGV01000056_gene1150 5.278e-27 112.0 COG1372@1|root,COG1372@2|Bacteria 2|Bacteria L intein-mediated protein splicing - - 1.1.98.6,3.6.3.14,3.6.3.15,4.1.1.35 ko:K02117,ko:K08678,ko:K21636 ko00190,ko00230,ko00240,ko00520,ko01100,map00190,map00230,map00240,map00520,map01100 M00053,M00159,M00361 R01384,R11633,R11634,R11635,R11636 RC00508,RC00613 ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-cone,Intein_splicing,LAGLIDADG_3,NRDD,PT-HINT CMS1_k127_1834029_6 1144275.COCOR_07715 5.952e-08 59.0 COG4223@1|root,COG4223@2|Bacteria 2|Bacteria DZ transferase activity, transferring acyl groups other than amino-acyl groups - - - - - - - - - - - - AHH,SLH CMS1_k127_1834029_5 1297742.A176_05989 2.483e-09 66.0 28UXW@1|root,2ZH1P@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1834029_0 1190606.AJYG01000029_gene3049 1.036e-70 241.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1XUZV@135623|Vibrionales 135623|Vibrionales C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate tdh GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008743,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_1834055_3 404589.Anae109_3935 6.773e-15 74.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,42PPW@68525|delta/epsilon subdivisions,2WM1S@28221|Deltaproteobacteria,2YVFT@29|Myxococcales 28221|Deltaproteobacteria L Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC CMS1_k127_1834055_1 1207055.C100_12325 6.548e-25 115.0 COG5340@1|root,COG5340@2|Bacteria,1RDP9@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator, AbiEi antitoxin - - - - - - - - - - - - AbiEi_1,AbiEi_4 CMS1_k127_1834055_0 483219.LILAB_33175 2.09e-131 430.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,2Z141@29|Myxococcales 28221|Deltaproteobacteria L transposase mutator type - - - - - - - - - - - - Transposase_mut CMS1_k127_1834055_2 404589.Anae109_3496 5.903e-16 78.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C CMS1_k127_1834055_4 765914.ThisiDRAFT_2799 3.056e-06 49.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria 1224|Proteobacteria M Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 CMS1_k127_1840765_5 1179773.BN6_17230 1.474e-21 106.0 COG0477@1|root,COG2814@2|Bacteria,2GMKX@201174|Actinobacteria,4DY8V@85010|Pseudonocardiales 201174|Actinobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 CMS1_k127_1840765_7 525257.HMPREF0204_12176 1.283e-11 72.0 COG2318@1|root,COG2318@2|Bacteria,4NNMT@976|Bacteroidetes,1I21N@117743|Flavobacteriia,3ZQWE@59732|Chryseobacterium 976|Bacteroidetes S Damage-inducible protein DinB - - - - - - - - - - - - DinB CMS1_k127_1840765_4 1379698.RBG1_1C00001G0336 1.863e-39 156.0 COG5588@1|root,COG5588@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1326) - - - - - - - - - - - - DUF1326 CMS1_k127_1840765_2 234267.Acid_5283 2.363e-76 277.0 COG0436@1|root,COG0436@2|Bacteria,3Y2VQ@57723|Acidobacteria 57723|Acidobacteria E PFAM Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 CMS1_k127_1840765_6 1267533.KB906735_gene5069 6.304e-17 86.0 COG1950@1|root,COG1950@2|Bacteria,3Y5FT@57723|Acidobacteria,2JJY4@204432|Acidobacteriia 204432|Acidobacteriia S Mycobacterial 4 TMS phage holin, superfamily IV - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 CMS1_k127_1840765_3 867903.ThesuDRAFT_01649 3.272e-52 195.0 COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,3WCI6@538999|Clostridiales incertae sedis 186801|Clostridia S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis ylmE - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N CMS1_k127_1840765_8 1282361.ABAC402_00395 1.939e-09 64.0 COG1872@1|root,COG1872@2|Bacteria,1N6V2@1224|Proteobacteria,2UF67@28211|Alphaproteobacteria,2KH69@204458|Caulobacterales 204458|Caulobacterales S Belongs to the UPF0235 family - - - ko:K09131 - - - - ko00000 - - - DUF167 CMS1_k127_1840765_1 575540.Isop_0275 9.569e-94 320.0 COG0005@1|root,COG0005@2|Bacteria,2IX9R@203682|Planctomycetes 203682|Planctomycetes F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate - - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 CMS1_k127_1840765_0 1379698.RBG1_1C00001G0103 0.0 1051.0 COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria 2|Bacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 CMS1_k127_1843750_2 459349.CLOAM1520 6.171e-06 60.0 COG4412@1|root,COG4412@2|Bacteria,2NQZW@2323|unclassified Bacteria 2|Bacteria S Fibronectin type 3 domain - - - - - - - - - - - - Cleaved_Adhesin,DUF4968,DUF5110,F5_F8_type_C,FlgD_ig,Glyco_hydro_31,W_rich_C,fn3 CMS1_k127_1843750_1 1278073.MYSTI_05613 3.707e-95 348.0 COG0421@1|root,COG0421@2|Bacteria,1QX98@1224|Proteobacteria,43C2D@68525|delta/epsilon subdivisions,2X7CZ@28221|Deltaproteobacteria,2Z3FM@29|Myxococcales 28221|Deltaproteobacteria E Spermine/spermidine synthase domain speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth CMS1_k127_1843750_0 1123073.KB899241_gene2226 3.06e-259 815.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1X333@135614|Xanthomonadales 135614|Xanthomonadales I converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 CMS1_k127_1849847_3 1041159.AZUW01000043_gene1412 1.732e-05 52.0 COG4319@1|root,COG4319@2|Bacteria,1RF3Q@1224|Proteobacteria,2U78H@28211|Alphaproteobacteria,4BJV7@82115|Rhizobiaceae 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS1_k127_1849847_1 469383.Cwoe_4585 3.246e-54 203.0 COG0500@1|root,COG2226@2|Bacteria,2GM0Y@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 CMS1_k127_1849847_0 1235790.C805_01222 4.175e-61 216.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,25V1F@186806|Eubacteriaceae 186801|Clostridia P Belongs to the ABC transporter superfamily ugpC_1 - 3.6.3.20 ko:K05816,ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00198,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1,3.A.1.1.3 - - ABC_tran,TOBE,TOBE_2 CMS1_k127_1858655_4 1192034.CAP_5439 1.126e-27 125.0 COG2203@1|root,COG2204@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria,2YUZY@29|Myxococcales 28221|Deltaproteobacteria T HD domain - - - - - - - - - - - - GAF_2,GAF_3,HD,Response_reg CMS1_k127_1858655_3 635013.TherJR_2805 1.157e-29 136.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,249Y6@186801|Clostridia,267E8@186807|Peptococcaceae 186801|Clostridia T TIGRFAM Diguanylate cyclase - - - - - - - - - - - - GAF,GAF_2,GGDEF CMS1_k127_1858655_2 643648.Slip_1776 5.053e-41 164.0 COG1639@1|root,COG1639@2|Bacteria,1TPRT@1239|Firmicutes,249CG@186801|Clostridia,42KAI@68298|Syntrophomonadaceae 186801|Clostridia T HDOD domain - - - - - - - - - - - - HDOD,Response_reg CMS1_k127_1858655_1 1480694.DC28_02445 8.772e-60 216.0 COG1191@1|root,COG1191@2|Bacteria,2J5RA@203691|Spirochaetes 203691|Spirochaetes K Belongs to the sigma-70 factor family fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 CMS1_k127_1858655_0 643648.Slip_0975 7.063e-66 237.0 COG0455@1|root,COG0455@2|Bacteria,1TRZ5@1239|Firmicutes,24AIN@186801|Clostridia,42JUH@68298|Syntrophomonadaceae 186801|Clostridia D Belongs to the ParA family flhG - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,ParA CMS1_k127_1858655_5 1235835.C814_03257 1.538e-05 55.0 COG3190@1|root,COG3190@2|Bacteria,1VKJM@1239|Firmicutes,24UDW@186801|Clostridia,3WSQX@541000|Ruminococcaceae 186801|Clostridia N Flagellar biosynthesis protein, FliO - - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO CMS1_k127_1858864_0 1379698.RBG1_1C00001G1029 2.423e-167 531.0 COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria 2|Bacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_1858864_2 219305.MCAG_01340 1.337e-54 219.0 COG1619@1|root,COG1619@2|Bacteria,2HPR8@201174|Actinobacteria,4D9C0@85008|Micromonosporales 201174|Actinobacteria V peptidase U61 LD-carboxypeptidase A - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 CMS1_k127_1858864_3 518766.Rmar_1876 1.285e-25 123.0 COG2027@1|root,COG2027@2|Bacteria,4NGIQ@976|Bacteroidetes,1FIVK@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M D-Ala-D-Ala carboxypeptidase 3 (S13) family - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 CMS1_k127_1858864_1 945713.IALB_1171 3.353e-56 210.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - PorP_SprF CMS1_k127_1860638_1 234267.Acid_4393 1.37e-83 288.0 COG0515@1|root,COG0515@2|Bacteria 234267.Acid_4393|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_1860638_0 1210884.HG799462_gene8307 3.969e-159 509.0 COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes 203682|Planctomycetes P COG0798 Arsenite efflux pump ACR3 and related - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF CMS1_k127_1864770_2 1033743.CAES01000018_gene2556 2.624e-110 361.0 COG1089@1|root,COG1089@2|Bacteria,1UJFF@1239|Firmicutes,4HF5Y@91061|Bacilli,275YJ@186822|Paenibacillaceae 91061|Bacilli M Polysaccharide biosynthesis protein - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd CMS1_k127_1864770_3 1278073.MYSTI_05892 4.99e-67 239.0 COG1089@1|root,COG1089@2|Bacteria,1QXV3@1224|Proteobacteria,4347Z@68525|delta/epsilon subdivisions,2X7I2@28221|Deltaproteobacteria,2YXC2@29|Myxococcales 28221|Deltaproteobacteria M Polysaccharide biosynthesis protein - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd CMS1_k127_1864770_0 1379270.AUXF01000004_gene3343 8.207e-145 471.0 COG1004@1|root,COG1004@2|Bacteria,1ZTH3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M UDP binding domain - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N CMS1_k127_1864770_4 1379698.RBG1_1C00001G0167 3.13e-58 224.0 COG1898@1|root,COG1898@2|Bacteria,2NP7U@2323|unclassified Bacteria 2|Bacteria M dTDP-4-dehydrorhamnose 3,5-epimerase - - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom CMS1_k127_1864770_1 479434.Sthe_0968 5.516e-125 411.0 COG1088@1|root,COG1088@2|Bacteria,2G5KR@200795|Chloroflexi,27XGB@189775|Thermomicrobia 189775|Thermomicrobia M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd CMS1_k127_1869456_6 891968.Anamo_0390 8.318e-32 126.0 COG1692@1|root,COG1692@2|Bacteria,3T9TA@508458|Synergistetes 508458|Synergistetes S Metallophosphoesterase - - - ko:K09769 - - - - ko00000 - - - YmdB CMS1_k127_1869456_1 1379698.RBG1_1C00001G1123 3.393e-176 566.0 COG1418@1|root,COG1418@2|Bacteria,2NNU5@2323|unclassified Bacteria 2|Bacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 CMS1_k127_1869456_8 880073.Calab_3701 3.744e-12 74.0 COG3027@1|root,COG3027@2|Bacteria,2NQ5R@2323|unclassified Bacteria 2|Bacteria D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division zapA - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA CMS1_k127_1869456_2 1125863.JAFN01000001_gene1869 2.354e-157 525.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Phenylalanyl-tRNA synthetase, beta subunit pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind CMS1_k127_1869456_3 663278.Ethha_1970 2.769e-107 357.0 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WGWV@541000|Ruminococcaceae 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d CMS1_k127_1869456_5 429009.Adeg_0536 1.645e-36 141.0 COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,42GJ4@68295|Thermoanaerobacterales 186801|Clostridia J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 CMS1_k127_1869456_9 411461.DORFOR_01711 3.371e-08 59.0 COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,27VVS@189330|Dorea 186801|Clostridia J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p CMS1_k127_1869456_4 1379698.RBG1_1C00001G1116 9.852e-56 204.0 COG0290@1|root,COG0290@2|Bacteria,2NPDH@2323|unclassified Bacteria 2|Bacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N CMS1_k127_1869456_0 1123371.ATXH01000013_gene1505 3.805e-225 715.0 COG0441@1|root,COG0441@2|Bacteria,2GH53@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD CMS1_k127_1869456_7 357808.RoseRS_3908 4.057e-18 98.0 COG1807@1|root,COG1807@2|Bacteria,2GAQ1@200795|Chloroflexi,3770G@32061|Chloroflexia 32061|Chloroflexia M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 CMS1_k127_186967_1 227377.CBU_1050 2.842e-16 82.0 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,1JEYY@118969|Legionellales 118969|Legionellales J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA CMS1_k127_186967_0 1121918.ARWE01000001_gene894 5.031e-50 194.0 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,43SCP@69541|Desulfuromonadales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain gnfL - 2.7.13.3 ko:K02668,ko:K07708,ko:K07709 ko02020,map02020 M00497,M00499,M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8 CMS1_k127_1873657_1 243090.RB4667 2.062e-19 89.0 COG1520@1|root,COG1520@2|Bacteria 243090.RB4667|- S amino acid activation for nonribosomal peptide biosynthetic process - - - - - - - - - - - - - CMS1_k127_1873657_0 309807.SRU_0883 9.755e-105 357.0 COG0457@1|root,COG0457@2|Bacteria,4NFMI@976|Bacteroidetes,1FK5M@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 CMS1_k127_1875768_0 326427.Cagg_3721 0.0 1271.0 COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi,374T1@32061|Chloroflexia 32061|Chloroflexia C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C CMS1_k127_1876723_2 1123354.AUDR01000015_gene350 3.922e-97 321.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,1KRE8@119069|Hydrogenophilales 119069|Hydrogenophilales S tRNA-splicing ligase RtcB - - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB CMS1_k127_1876723_4 316067.Geob_0673 5.197e-52 205.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42UDS@68525|delta/epsilon subdivisions,2WPGE@28221|Deltaproteobacteria,43SVS@69541|Desulfuromonadales 28221|Deltaproteobacteria C Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR CMS1_k127_1876723_3 28444.JODQ01000001_gene1887 7.384e-78 270.0 COG4122@1|root,COG4122@2|Bacteria,2IFBF@201174|Actinobacteria 201174|Actinobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 CMS1_k127_1876723_5 639282.DEFDS_1443 2.692e-43 162.0 COG2905@1|root,COG2905@2|Bacteria,2GGGX@200930|Deferribacteres 200930|Deferribacteres T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS CMS1_k127_1876723_1 338963.Pcar_1613 1.623e-135 441.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,43SCX@69541|Desulfuromonadales 28221|Deltaproteobacteria F Carbamoyl-phosphate synthase small chain, CPSase domain carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase CMS1_k127_1876723_0 1123368.AUIS01000012_gene780 1.896e-263 822.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,2NCT0@225057|Acidithiobacillales 225057|Acidithiobacillales F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS CMS1_k127_1883644_0 498761.HM1_2458 4.008e-71 255.0 COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia 186801|Clostridia J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f CMS1_k127_1891253_1 944481.JAFP01000001_gene301 1.243e-10 70.0 COG0392@1|root,COG0392@2|Bacteria,1MVZ8@1224|Proteobacteria,42WVD@68525|delta/epsilon subdivisions,2WSWS@28221|Deltaproteobacteria,2M6G3@213113|Desulfurellales 28221|Deltaproteobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS1_k127_1891253_0 880073.Calab_1385 2.33e-107 386.0 COG1807@1|root,COG1807@2|Bacteria,2NP0P@2323|unclassified Bacteria 2|Bacteria M Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723,PMT,PMT_2,TPR_19 CMS1_k127_1896910_0 1095769.CAHF01000022_gene432 0.0 1163.0 COG3209@1|root,COG3209@2|Bacteria,1QJCC@1224|Proteobacteria,2WF53@28216|Betaproteobacteria 28216|Betaproteobacteria M COG3209 Rhs family protein - - - ko:K11021 - - - - ko00000,ko02042 - - - SpvB,TcdB_toxin_midC,TcdB_toxin_midN CMS1_k127_1896910_8 1094557.ME3_01177 6.949e-05 54.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2TVQD@28211|Alphaproteobacteria,48T75@772|Bartonellaceae 28211|Alphaproteobacteria M PPIC-type PPIASE domain ppiC - 5.2.1.8 ko:K01802,ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3 CMS1_k127_1896910_1 215803.DB30_0684 2.918e-205 700.0 COG1404@1|root,COG3291@1|root,COG3509@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the peptidase S8 family - - - - - - - - - - - - Big_3_2,Big_3_3,Inhibitor_I9,Peptidase_S8 CMS1_k127_1896910_5 1242864.D187_002603 2.061e-35 158.0 COG1404@1|root,COG3055@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria 2|Bacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - 3.4.21.62 ko:K01342,ko:K12287,ko:K20276 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko02044,ko03110 - - - FG-GAP,Kelch_1,Kelch_4,PPC,Peptidase_C2,Peptidase_S8,VCBS CMS1_k127_1896910_2 448385.sce1448 2.347e-139 456.0 2C4AC@1|root,30014@2|Bacteria,1NW5K@1224|Proteobacteria,43DT1@68525|delta/epsilon subdivisions,2X8VB@28221|Deltaproteobacteria,2Z0JE@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_1896910_7 622637.KE124774_gene995 3.4e-13 73.0 COG5513@1|root,COG5513@2|Bacteria,1NH67@1224|Proteobacteria,2UIDX@28211|Alphaproteobacteria,370YD@31993|Methylocystaceae 28211|Alphaproteobacteria S Chagasin family peptidase inhibitor I42 - - - ko:K14475 ko05143,map05143 - - - ko00000,ko00001 - - - Inhibitor_I42 CMS1_k127_1896910_3 671143.DAMO_0892 5.89e-119 393.0 COG4870@1|root,COG4870@2|Bacteria 2|Bacteria O transferase activity, transferring glycosyl groups - - 3.4.22.38 ko:K01371 ko04142,ko04210,ko04380,ko04620,ko05323,map04142,map04210,map04380,map04620,map05323 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_C1 CMS1_k127_1899349_0 1379698.RBG1_1C00001G0961 7.629e-174 562.0 COG0550@1|root,COG0550@2|Bacteria,2NNS8@2323|unclassified Bacteria 2|Bacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom CMS1_k127_1900003_5 1379698.RBG1_1C00001G1299 9.807e-37 156.0 COG1622@1|root,COG1622@2|Bacteria,2NNSH@2323|unclassified Bacteria 2|Bacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 CMS1_k127_1900003_4 1379698.RBG1_1C00001G1300 3.001e-43 181.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c pbrT - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - Cytochrom_C,Cytochrome_CBB3,FTR1 CMS1_k127_1900003_1 1379698.RBG1_1C00001G1301 2.57e-92 325.0 COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria 2|Bacteria P ABC-type Zn2 transport system, periplasmic component surface adhesin actF - - - - - - - - - - - - CMS1_k127_1900003_2 1379698.RBG1_1C00001G1302 4.046e-51 187.0 COG2010@1|root,COG2010@2|Bacteria,2NPQJ@2323|unclassified Bacteria 2|Bacteria C Cytochrome C oxidase, cbb3-type, subunit III actE - - - - - - - - - - - Cytochrome_CBB3 CMS1_k127_1900003_3 1379698.RBG1_1C00001G1303 2.337e-49 185.0 COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria 2|Bacteria C Protein of unknown function (DUF3341) actD - - - - - - - - - - - DUF3341 CMS1_k127_1900003_0 1340493.JNIF01000004_gene1031 3.223e-164 523.0 COG5557@1|root,COG5557@2|Bacteria,3Y3NS@57723|Acidobacteria 57723|Acidobacteria C PFAM Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD CMS1_k127_1900328_2 1121945.ATXS01000001_gene2367 1.469e-19 101.0 arCOG14669@1|root,arCOG14669@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1900328_3 404589.Anae109_1777 1.011e-08 68.0 COG0457@1|root,COG0457@2|Bacteria 404589.Anae109_1777|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_1900328_1 502025.Hoch_0469 6.017e-20 102.0 COG1413@1|root,COG1413@2|Bacteria,1QAW1@1224|Proteobacteria,43E4E@68525|delta/epsilon subdivisions,2WZPH@28221|Deltaproteobacteria,2Z2H1@29|Myxococcales 28221|Deltaproteobacteria C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS1_k127_1900328_0 1346791.M529_12365 1.148e-62 228.0 COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,2TVZ5@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Glycosyl transferase, family 2 - - - - - - - - - - - - Glyco_tranf_2_3 CMS1_k127_1900342_4 518766.Rmar_0744 5.586e-07 63.0 COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,1FKAM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 CMS1_k127_1900342_0 926550.CLDAP_04870 2.592e-105 375.0 COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi 200795|Chloroflexi G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH CMS1_k127_1900342_3 1388763.O165_007015 6.203e-55 215.0 COG3391@1|root,COG3391@2|Bacteria,1PGT6@1224|Proteobacteria,1RXFC@1236|Gammaproteobacteria,1YZCY@136845|Pseudomonas putida group 1236|Gammaproteobacteria S amine dehydrogenase activity - - - - - - - - - - - - - CMS1_k127_1900342_1 443144.GM21_0249 3.553e-63 241.0 COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,42RS2@68525|delta/epsilon subdivisions,2X9GK@28221|Deltaproteobacteria,43W2H@69541|Desulfuromonadales 28221|Deltaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR CMS1_k127_1900342_2 1121288.AULL01000011_gene1078 3.638e-61 226.0 COG3033@1|root,COG3033@2|Bacteria,4NEP4@976|Bacteroidetes,1I067@117743|Flavobacteriia,3ZNS9@59732|Chryseobacterium 976|Bacteroidetes E Beta-eliminating lyase tpl - - - - - - - - - - - Beta_elim_lyase CMS1_k127_1900535_0 909663.KI867150_gene2708 5.126e-17 87.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42T20@68525|delta/epsilon subdivisions,2WP7S@28221|Deltaproteobacteria,2MQGC@213462|Syntrophobacterales 28221|Deltaproteobacteria L PFAM Integrase, catalytic - - - - - - - - - - - - rve CMS1_k127_1900535_2 1524467.IV04_14715 1.176e-09 68.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,1RPJM@1236|Gammaproteobacteria,402Y4@613|Serratia 1236|Gammaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 CMS1_k127_1900535_1 945713.IALB_1715 9.963e-11 75.0 COG4409@1|root,COG4409@2|Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - BNR_2,F5_F8_type_C CMS1_k127_1901553_1 234267.Acid_0687 8.316e-55 206.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y6TZ@57723|Acidobacteria 2|Bacteria S Tetratricopeptide repeats - - - - - - - - - - - - TPR_16,TPR_2 CMS1_k127_1901553_0 234267.Acid_5749 7.509e-150 503.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS1_k127_1906860_7 1242864.D187_002300 6.291e-10 61.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2WK9P@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_1906860_1 483219.LILAB_04855 1.518e-130 434.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,4315B@68525|delta/epsilon subdivisions 1224|Proteobacteria S Insulinase (Peptidase family M16) MA20_05660 - 2.7.7.6 ko:K00960,ko:K07263,ko:K07623 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_1906860_6 215803.DB30_4659 7.649e-13 78.0 2AIX7@1|root,319EV@2|Bacteria,1Q2IE@1224|Proteobacteria,43856@68525|delta/epsilon subdivisions,2X9XV@28221|Deltaproteobacteria,2YVTJ@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_1906860_5 1280390.CBQR020000171_gene4524 7.844e-14 74.0 COG4877@1|root,COG4877@2|Bacteria,1VEY1@1239|Firmicutes,4HNMN@91061|Bacilli,26ZV3@186822|Paenibacillaceae 91061|Bacilli S Ribbon-helix-helix domain protein - - - - - - - - - - - - Arc,HicB,RHH_5 CMS1_k127_1906860_2 709986.Deima_1037 3.349e-94 317.0 COG0330@1|root,COG0330@2|Bacteria,1WIW0@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 CMS1_k127_1906860_8 1144305.PMI02_02410 0.0002199 50.0 COG2945@1|root,COG2945@2|Bacteria 2|Bacteria - - - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009111,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0034641,GO:0042365,GO:0042737,GO:0042802,GO:0042803,GO:0042816,GO:0042820,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046483,GO:0046700,GO:0046983,GO:0047411,GO:0071704,GO:0072524,GO:0072526,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.1.29 ko:K07020,ko:K18614 ko00750,ko01120,map00750,map01120 - R01649 RC00300,RC00575 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_5,Abhydrolase_6,LIP,UPF0227 CMS1_k127_1906860_0 323261.Noc_1687 1.458e-252 797.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn CMS1_k127_1906860_4 234267.Acid_5312 1.654e-23 109.0 COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria 57723|Acidobacteria S PFAM Iron sulphur-containing domain, CDGSH-type - - - - - - - - - - - - zf-CDGSH CMS1_k127_1906860_3 1173026.Glo7428_3944 3.539e-50 190.0 COG1503@1|root,COG1503@2|Bacteria,1G29A@1117|Cyanobacteria 1117|Cyanobacteria J translation release factor activity - - - - - - - - - - - - - CMS1_k127_1944944_1 880073.Calab_0677 4.305e-48 193.0 COG1196@1|root,COG1196@2|Bacteria,2NNSS@2323|unclassified Bacteria 2|Bacteria D nuclear chromosome segregation - - - - - - - - - - - - - CMS1_k127_1944944_0 945713.IALB_0313 1.437e-156 518.0 2CD20@1|root,2Z7SQ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1944944_2 1089551.KE386572_gene2233 1.773e-14 77.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,4BSGF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 CMS1_k127_1948342_4 945713.IALB_0545 7.467e-22 95.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion - - - - - - - - - - - - Band_7 CMS1_k127_1948342_2 1532557.JL37_21470 1.868e-59 212.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2VRGS@28216|Betaproteobacteria,3T7P4@506|Alcaligenaceae 28216|Betaproteobacteria S Appr-1'-p processing enzyme ymdB - - - - - - - - - - - Macro CMS1_k127_1948342_0 1068980.ARVW01000001_gene3957 2.298e-121 399.0 COG0346@1|root,COG0346@2|Bacteria,2IAYN@201174|Actinobacteria,4DYU3@85010|Pseudonocardiales 201174|Actinobacteria E Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K15975 - - - - ko00000 - - - Glyoxalase CMS1_k127_1948342_1 420324.KI911943_gene5343 9.163e-63 238.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 CMS1_k127_1948342_3 204669.Acid345_4024 5.992e-35 141.0 COG1309@1|root,COG1309@2|Bacteria,3Y5TS@57723|Acidobacteria,2JK51@204432|Acidobacteriia 204432|Acidobacteriia K WHG domain - - - - - - - - - - - - TetR_N,WHG CMS1_k127_1949297_0 323259.Mhun_0648 8.177e-69 248.0 COG0614@1|root,COG1404@1|root,arCOG00702@2157|Archaea,arCOG03611@2157|Archaea,2XUT1@28890|Euryarchaeota,2NBHB@224756|Methanomicrobia 28890|Euryarchaeota O Subtilase family hly GO:0005575,GO:0005576 - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PKD,Peptidase_S8,TAT_signal CMS1_k127_1949297_1 666681.M301_2067 7.482e-09 63.0 COG4625@1|root,COG4625@2|Bacteria,1PHUK@1224|Proteobacteria,2VP7M@28216|Betaproteobacteria,2KN9K@206350|Nitrosomonadales 206350|Nitrosomonadales S TIGRFAM outer membrane autotransporter barrel domain protein - - - - - - - - - - - - Autotransporter CMS1_k127_1949309_1 290317.Cpha266_1203 1.843e-18 91.0 COG3210@1|root,COG4625@1|root,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis - - - - - - - - - - - - Autotransporter,PATR CMS1_k127_1949309_0 113355.CM001775_gene1664 1.788e-125 415.0 COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1G32M@1117|Cyanobacteria 1117|Cyanobacteria Q Belongs to the peptidase S8 family - - - - - - - - - - - - PPC,VCBS CMS1_k127_1969846_3 1192034.CAP_3514 1.919e-47 177.0 COG1595@1|root,COG1595@2|Bacteria,1RINW@1224|Proteobacteria,4385N@68525|delta/epsilon subdivisions,2X3FI@28221|Deltaproteobacteria,2YVVV@29|Myxococcales 28221|Deltaproteobacteria K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF CMS1_k127_1969846_0 1267535.KB906767_gene447 2.898e-153 520.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia 204432|Acidobacteriia T Tetratricopeptide repeat - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_12 CMS1_k127_1969846_1 324602.Caur_2349 6.022e-121 400.0 COG4638@1|root,COG4638@2|Bacteria,2G720@200795|Chloroflexi,377BT@32061|Chloroflexia 32061|Chloroflexia P PFAM Rieske 2Fe-2S domain protein - - 1.14.15.7 ko:K00479,ko:K00499 ko00260,map00260 - R07409 RC00087 ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A CMS1_k127_1969846_2 1286106.MPL1_10752 1.363e-60 225.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,45ZZ5@72273|Thiotrichales 72273|Thiotrichales M peptidase - - - - - - - - - - - - OapA,Peptidase_M23 CMS1_k127_1980907_2 1121918.ARWE01000001_gene2797 2.336e-63 230.0 COG1752@1|root,COG1752@2|Bacteria,1PHH5@1224|Proteobacteria,4379Q@68525|delta/epsilon subdivisions,2X2DQ@28221|Deltaproteobacteria,43UU3@69541|Desulfuromonadales 28221|Deltaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin CMS1_k127_1980907_4 1192034.CAP_5195 1.137e-56 210.0 COG2040@1|root,COG2040@2|Bacteria,1Q99A@1224|Proteobacteria,43DPD@68525|delta/epsilon subdivisions,2WZAC@28221|Deltaproteobacteria,2Z1PN@29|Myxococcales 28221|Deltaproteobacteria H Homocysteine S-methyltransferase - - - - - - - - - - - - S-methyl_trans CMS1_k127_1980907_1 378806.STAUR_6614 9.315e-93 334.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,430H1@68525|delta/epsilon subdivisions,2WVZX@28221|Deltaproteobacteria,2YUWZ@29|Myxococcales 28221|Deltaproteobacteria L Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,NUDIX CMS1_k127_1980907_3 1185876.BN8_05038 9.516e-62 220.0 2AYX9@1|root,31R2Z@2|Bacteria,4NNS4@976|Bacteroidetes,47RDY@768503|Cytophagia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_1980907_0 204669.Acid345_1786 3.512e-177 565.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia 204432|Acidobacteriia C Dehydrogenase E1 component - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C CMS1_k127_1988881_0 477974.Daud_0538 5.56e-59 218.0 COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,267DC@186807|Peptococcaceae 186801|Clostridia T Metal-dependent phosphohydrolase, HD region - - - - - - - - - - - - GAF_2,GGDEF,HD,PAS,PocR,SBP_bac_3 CMS1_k127_1988881_2 518766.Rmar_1323 2.125e-14 79.0 COG2172@1|root,COG2172@2|Bacteria,4NRAA@976|Bacteroidetes 976|Bacteroidetes T Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase rsbW - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 CMS1_k127_1988881_1 1382359.JIAL01000001_gene1199 1.304e-55 219.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia 204432|Acidobacteriia KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GAF_3,SpoIIE CMS1_k127_1992900_0 485915.Dret_1750 1.165e-226 719.0 COG0021@1|root,COG0021@2|Bacteria 2|Bacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_N,XFP,XFP_N CMS1_k127_1997611_0 401526.TcarDRAFT_2204 3.419e-115 382.0 COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,4H27Q@909932|Negativicutes 909932|Negativicutes G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 CMS1_k127_1997611_1 247490.KSU1_C1186 4.194e-51 190.0 COG0580@1|root,COG0580@2|Bacteria,2IZDN@203682|Planctomycetes 203682|Planctomycetes U Belongs to the MIP aquaporin (TC 1.A.8) family - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP CMS1_k127_2008870_2 1236689.MMALV_10860 1.501e-64 235.0 COG0492@1|root,arCOG01296@2157|Archaea,2XTJW@28890|Euryarchaeota,3F2RU@33867|unclassified Euryarchaeota 28890|Euryarchaeota O Pyridine nucleotide-disulphide oxidoreductase trxB - 1.18.1.2,1.19.1.1,1.8.1.9 ko:K00384,ko:K03387,ko:K21567 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Glutaredoxin,Pyr_redox_2 CMS1_k127_2008870_1 314230.DSM3645_22239 1.711e-79 277.0 COG0535@1|root,COG0535@2|Bacteria,2J0M5@203682|Planctomycetes 203682|Planctomycetes S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM CMS1_k127_2008870_0 314230.DSM3645_22234 8.635e-88 299.0 COG0639@1|root,COG0639@2|Bacteria,2J22W@203682|Planctomycetes 203682|Planctomycetes T Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 CMS1_k127_2008870_3 351160.RCIX86 1.835e-50 196.0 COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia 224756|Methanomicrobia G MFS/sugar transport protein - - - - - - - - - - - - MFS_1 CMS1_k127_2010561_0 204669.Acid345_2395 6.339e-90 316.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K08282,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16,TPR_2,TPR_8 CMS1_k127_2010561_1 251221.35211462 5.605e-70 257.0 COG3291@1|root,COG3291@2|Bacteria,1GFMJ@1117|Cyanobacteria 1117|Cyanobacteria S Pregnancy-associated plasma protein-A - - - - - - - - - - - - Peptidase_M43 CMS1_k127_2010561_2 1121930.AQXG01000007_gene417 4.596e-16 92.0 COG0737@1|root,COG0737@2|Bacteria 2|Bacteria F nucleotide catabolic process - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - - - - - - - - - - Cytochrome_C554 CMS1_k127_2010561_3 1394178.AWOO02000003_gene2663 0.0008567 50.0 COG3291@1|root,COG3291@2|Bacteria,2GKA0@201174|Actinobacteria,4EJAC@85012|Streptosporangiales 201174|Actinobacteria S Pregnancy-associated plasma protein-A - - - - - - - - - - - - Peptidase_M43 CMS1_k127_2015120_0 1202768.JROF01000016_gene1345 3.24e-62 235.0 COG1169@1|root,arCOG02015@2157|Archaea,2XUD1@28890|Euryarchaeota,23SRN@183963|Halobacteria 183963|Halobacteria H Isochorismate synthase menF - 5.4.4.2 ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind CMS1_k127_2015120_1 1379698.RBG1_1C00001G1306 1.851e-52 191.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process actA - - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_C552,Cytochrom_CIII,Cytochrome_C7 CMS1_k127_2015120_2 1379698.RBG1_1C00001G1305 2.306e-16 89.0 COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S dicluster domain actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molydop_binding CMS1_k127_2032307_4 411467.BACCAP_03889 3.944e-17 81.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,268CX@186813|unclassified Clostridiales 186801|Clostridia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 CMS1_k127_2032307_3 1121033.AUCF01000003_gene3184 2.184e-49 191.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria,2JQMD@204441|Rhodospirillales 204441|Rhodospirillales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_25,Methyltransf_31 CMS1_k127_2032307_1 398767.Glov_0818 1.215e-137 456.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the EPSP synthase family. MurA subfamily murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase CMS1_k127_2032307_0 477974.Daud_1094 2.74e-138 462.0 COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,260IK@186807|Peptococcaceae 186801|Clostridia J Elongation factor Tu domain 2 selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 CMS1_k127_2032307_2 335543.Sfum_1010 2.856e-63 245.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MR79@213462|Syntrophobacterales 28221|Deltaproteobacteria KT Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat CMS1_k127_2035912_4 926550.CLDAP_23390 3.546e-05 57.0 COG1807@1|root,COG1807@2|Bacteria,2G9BJ@200795|Chloroflexi 2|Bacteria M Protein of unknown function (DUF2723) - - - ko:K14340 - - - - ko00000,ko01000,ko01003 - - - PMT_2 CMS1_k127_2035912_0 215803.DB30_2650 2.147e-307 953.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2YU1K@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2638 PEPCK_C,PEPCK_N CMS1_k127_2035912_1 452637.Oter_4084 1.213e-144 482.0 COG0006@1|root,COG0006@2|Bacteria,46U30@74201|Verrucomicrobia 74201|Verrucomicrobia E Aminopeptidase P, N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 CMS1_k127_2035912_2 240015.ACP_2314 1.143e-75 267.0 COG0846@1|root,COG0846@2|Bacteria,3Y4T9@57723|Acidobacteria,2JKFP@204432|Acidobacteriia 204432|Acidobacteriia K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 CMS1_k127_2035912_3 240015.ACP_2205 3.322e-35 136.0 COG0010@1|root,COG0010@2|Bacteria,3Y46E@57723|Acidobacteria,2JIPY@204432|Acidobacteriia 204432|Acidobacteriia E Arginase family - - 3.5.3.1 ko:K01476 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00134 R00551 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase CMS1_k127_2040166_5 1210908.HSB1_09180 2.469e-06 58.0 COG3595@1|root,arCOG03825@2157|Archaea,2XWNU@28890|Euryarchaeota,23V5V@183963|Halobacteria 183963|Halobacteria S Putative adhesin - - - - - - - - - - - - DUF4097 CMS1_k127_2040166_3 379066.GAU_2724 4.975e-12 75.0 2F756@1|root,33ZKP@2|Bacteria,1ZU38@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2040166_2 1379270.AUXF01000001_gene2634 1.198e-51 190.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2040166_4 338966.Ppro_1650 2.165e-11 66.0 COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,42WU5@68525|delta/epsilon subdivisions,2WRRS@28221|Deltaproteobacteria,43SRB@69541|Desulfuromonadales 28221|Deltaproteobacteria H Protein of unknown function (DUF2905) - - - - - - - - - - - - DUF2905 CMS1_k127_2040166_1 452637.Oter_1656 4.749e-124 403.0 COG2013@1|root,COG2013@2|Bacteria,46SY6@74201|Verrucomicrobia 74201|Verrucomicrobia S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 CMS1_k127_2040166_0 378806.STAUR_7462 1.3e-145 489.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2WK9P@28221|Deltaproteobacteria,2YYYP@29|Myxococcales 28221|Deltaproteobacteria M Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_20409_1 292459.STH1332 3.14e-37 158.0 COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia 186801|Clostridia K Fibronectin-binding protein FbpA - - - - - - - - - - - DUF814,FbpA CMS1_k127_20409_2 1278073.MYSTI_05853 6.225e-30 137.0 COG0457@1|root,COG0457@2|Bacteria 1278073.MYSTI_05853|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_20409_0 868595.Desca_1278 7.34e-59 214.0 COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,2617V@186807|Peptococcaceae 186801|Clostridia S PFAM YicC-like family, N-terminal region yicC - - - - - - - - - - - DUF1732,YicC_N CMS1_k127_20409_3 997346.HMPREF9374_0943 6.724e-08 56.0 COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,4HAYW@91061|Bacilli,27BQA@186824|Thermoactinomycetaceae 91061|Bacilli F Guanylate kinase homologues. gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU15680 Guanylate_kin CMS1_k127_2048771_1 1303518.CCALI_01542 4.726e-41 173.0 COG0497@1|root,COG0497@2|Bacteria 2|Bacteria L DNA recombination recN GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - ko:K03631,ko:K13582 ko04112,map04112 - - - ko00000,ko00001,ko03400 - - - AAA_23,SMC_N CMS1_k127_2048771_0 1121430.JMLG01000003_gene554 1.216e-56 210.0 COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,260CC@186807|Peptococcaceae 186801|Clostridia F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS05480 NAD_kinase CMS1_k127_205607_1 1379698.RBG1_1C00001G0522 5.686e-124 414.0 COG0022@1|root,COG0022@2|Bacteria,2NNT2@2323|unclassified Bacteria 2|Bacteria C Transketolase, pyrimidine binding domain pdhB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944,GO:0140030,GO:0140032 1.2.4.1,1.2.4.4 ko:K00162,ko:K00167,ko:K21417 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2496c,iSB619.SA_RS05355,iYO844.BSU14590,iYO844.BSU24040 Transket_pyr,Transketolase_C CMS1_k127_205607_13 867903.ThesuDRAFT_02082 1.71e-44 167.0 COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,3WDHI@538999|Clostridiales incertae sedis 186801|Clostridia I Thioesterase superfamily yciA - - - - - - - - - - - 4HBT CMS1_k127_205607_2 1379698.RBG1_1C00001G0521 1.679e-119 393.0 COG1071@1|root,COG1071@2|Bacteria,2NPBB@2323|unclassified Bacteria 2|Bacteria C Dehydrogenase E1 component bfmBA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K00166,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C CMS1_k127_205607_0 266117.Rxyl_0133 5.968e-182 596.0 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CPA7@84995|Rubrobacteria 84995|Rubrobacteria P heavy metal translocating P-type ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase CMS1_k127_205607_3 671143.DAMO_2385 2.231e-117 391.0 COG0489@1|root,COG0489@2|Bacteria,2NNX1@2323|unclassified Bacteria 2|Bacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA CMS1_k127_205607_17 1379698.RBG1_1C00001G0517 1.402e-27 119.0 COG0489@1|root,COG0489@2|Bacteria,2NNX1@2323|unclassified Bacteria 2|Bacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA CMS1_k127_205607_8 189426.PODO_10160 2.434e-87 310.0 COG0477@1|root,COG2814@2|Bacteria,1TRDJ@1239|Firmicutes,4H9Q9@91061|Bacilli,26TUC@186822|Paenibacillaceae 91061|Bacilli EGP Multidrug transporter mdtG - - ko:K08161 - - - - ko00000,ko02000 2.A.1.2.20 - - MFS_1,MFS_1_like,Sugar_tr CMS1_k127_205607_14 234267.Acid_1797 8.076e-44 165.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4440,SnoaL_2,SnoaL_4 CMS1_k127_205607_16 1123504.JQKD01000033_gene5238 5.176e-35 141.0 COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,2VTR4@28216|Betaproteobacteria,4AEDJ@80864|Comamonadaceae 28216|Betaproteobacteria S Cupin superfamily (DUF985) - - - ko:K09705 - - - - ko00000 - - - Cupin_5 CMS1_k127_205607_11 309799.DICTH_1645 2.181e-50 197.0 COG0620@1|root,COG0620@2|Bacteria 2|Bacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 CMS1_k127_205607_4 1379698.RBG1_1C00001G1220 3.24e-117 402.0 COG0620@1|root,COG0620@2|Bacteria,2NPAE@2323|unclassified Bacteria 2|Bacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_4130,iECO103_1326.ECO103_4334,iECO111_1330.ECO111_4657,iECO26_1355.ECO26_4756,iECW_1372.ECW_m4131,iEKO11_1354.EKO11_4528,iPC815.YPO3788,iWFL_1372.ECW_m4131 Meth_synt_1,Meth_synt_2 CMS1_k127_205607_10 861299.J421_5993 2.162e-62 233.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_205607_7 204669.Acid345_1620 5.927e-90 322.0 COG1136@1|root,COG1136@2|Bacteria,3Y4A6@57723|Acidobacteria,2JMVQ@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_205607_6 861299.J421_5991 4.915e-92 324.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_205607_5 1379698.RBG1_1C00001G1668 2.586e-102 346.0 COG0577@1|root,COG0577@2|Bacteria,2NQJU@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_205607_15 748658.KB907328_gene1079 2.412e-41 161.0 COG3678@1|root,COG3678@2|Bacteria,1MZKK@1224|Proteobacteria 1224|Proteobacteria NPTU ATP-independent chaperone mediated protein folding - - - - - - - - - - - - LTXXQ,Metal_resist CMS1_k127_205607_12 404589.Anae109_1700 7.445e-45 183.0 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - HNH,HNH_4 CMS1_k127_205607_9 1128421.JAGA01000003_gene3488 1.349e-67 237.0 COG3662@1|root,COG3662@2|Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2236) - - - - - - - - - - - - DUF2236 CMS1_k127_2064660_4 1267534.KB906755_gene4826 7.431e-59 218.0 COG1181@1|root,COG1181@2|Bacteria,3Y6Z0@57723|Acidobacteria,2JKPX@204432|Acidobacteriia 204432|Acidobacteriia M ATP-grasp domain - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C CMS1_k127_2064660_6 457570.Nther_1051 3.232e-35 146.0 COG0827@1|root,COG0827@2|Bacteria 2|Bacteria L DNA restriction-modification system - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - DUF960,Eco57I,N6_Mtase,TaqI_C CMS1_k127_2064660_7 471853.Bcav_3024 1.218e-18 100.0 COG0596@1|root,COG0596@2|Bacteria,2I2VI@201174|Actinobacteria 201174|Actinobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6 CMS1_k127_2064660_2 1229172.JQFA01000002_gene3955 6.756e-81 277.0 COG4221@1|root,COG4221@2|Bacteria,1G182@1117|Cyanobacteria,1H965@1150|Oscillatoriales 1117|Cyanobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.276 ko:K05886 - - - - ko00000,ko01000 - - - adh_short CMS1_k127_2064660_3 246197.MXAN_7329 3.013e-79 286.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJWS@28221|Deltaproteobacteria,2YTWC@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C CMS1_k127_2064660_0 1499686.BN1079_00798 1.818e-163 552.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019405,GO:0019563,GO:0019751,GO:0033554,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901575,GO:1901615,GO:1901616 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - iE2348C_1286.E2348C_4230,iECNA114_1301.ECNA114_4065,iECSF_1327.ECSF_3786 FGGY_C,FGGY_N CMS1_k127_2064660_5 1242864.D187_005320 8.172e-45 175.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2Z1ZD@29|Myxococcales 28221|Deltaproteobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Hydrolase_4 CMS1_k127_2064660_1 1487953.JMKF01000078_gene4088 6.517e-109 366.0 COG0265@1|root,COG0265@2|Bacteria,1G0U4@1117|Cyanobacteria,1H8JK@1150|Oscillatoriales 1117|Cyanobacteria O PDZ domain (Also known as DHR or GLGF) - - - ko:K08372 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Trypsin_2 CMS1_k127_2064660_8 1142394.PSMK_14880 7.226e-09 70.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS1_k127_2064981_3 234267.Acid_4535 1.966e-39 149.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria 57723|Acidobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - PD40,Pkinase CMS1_k127_2064981_2 309807.SRU_1391 1.144e-43 169.0 COG0454@1|root,COG0456@2|Bacteria,4PF69@976|Bacteroidetes,1FK7D@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_2064981_6 234267.Acid_0752 1.547e-22 105.0 COG0517@1|root,COG0517@2|Bacteria,3Y8IB@57723|Acidobacteria 57723|Acidobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS CMS1_k127_2064981_5 1123371.ATXH01000001_gene1278 2.676e-34 138.0 COG0071@1|root,COG0071@2|Bacteria,2GHTW@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS1_k127_2064981_1 485915.Dret_0201 3.864e-53 209.0 COG4191@1|root,COG4191@2|Bacteria,1R6WR@1224|Proteobacteria,42PFK@68525|delta/epsilon subdivisions,2WJSP@28221|Deltaproteobacteria,2M8KY@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9 CMS1_k127_2064981_0 1125863.JAFN01000001_gene1446 6.58e-60 219.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_2077111_0 644966.Tmar_0252 3.502e-69 245.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRT@186801|Clostridia 186801|Clostridia P Rhodanese Homology Domain - - - - - - - - - - - - Lactamase_B,Rhodanese CMS1_k127_2077111_2 318464.IO99_01835 9.939e-13 70.0 COG3860@1|root,COG3860@2|Bacteria,1VICJ@1239|Firmicutes,24RGR@186801|Clostridia,36MQ0@31979|Clostridiaceae 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2087) - - - - - - - - - - - - DUF2087 CMS1_k127_2077111_1 861299.J421_2928 1.684e-13 73.0 COG2385@1|root,COG2385@2|Bacteria,1ZT25@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID CMS1_k127_20792_1 1408823.AXUS01000033_gene2829 5.841e-08 56.0 COG1978@1|root,COG1978@2|Bacteria,1UYNY@1239|Firmicutes,24G4U@186801|Clostridia,25S4M@186804|Peptostreptococcaceae 186801|Clostridia S Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) prdB - 1.21.4.1 ko:K10794 ko00330,map00330 - R02825 RC00790 ko00000,ko00001,ko01000 - - - GRDB CMS1_k127_20792_0 883080.HMPREF9697_03044 1.676e-21 102.0 2DQBG@1|root,335T7@2|Bacteria,1N795@1224|Proteobacteria 1224|Proteobacteria S Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - - - - - - - - - - GRDB CMS1_k127_2083691_0 265072.Mfla_1749 2.318e-33 133.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VUZH@28216|Betaproteobacteria,2KKCA@206350|Nitrosomonadales 206350|Nitrosomonadales S PFAM SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc CMS1_k127_2083691_2 395495.Lcho_3739 7.461e-11 76.0 COG0689@1|root,COG5276@1|root,COG0689@2|Bacteria,COG5276@2|Bacteria,1QVI5@1224|Proteobacteria 1224|Proteobacteria N alpha-L-arabinofuranosidase - - - - - - - - - - - - FG-GAP,He_PIG,LVIVD CMS1_k127_2083691_3 1089550.ATTH01000001_gene554 1.856e-05 58.0 COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,1FKAM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 CMS1_k127_2083691_1 1519464.HY22_11300 1.879e-30 137.0 COG4219@1|root,COG4219@2|Bacteria,1FF12@1090|Chlorobi 1090|Chlorobi KT Peptidase M56 - - - - - - - - - - - - - CMS1_k127_2102753_4 292459.STH2307 5.111e-19 93.0 COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,24BN3@186801|Clostridia 186801|Clostridia L Ser Thr phosphatase family protein - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,Metallophos_2 CMS1_k127_2102753_3 243231.GSU1422 6.606e-42 177.0 COG0419@1|root,COG0419@2|Bacteria,1Q1A7@1224|Proteobacteria,4375R@68525|delta/epsilon subdivisions,2X23H@28221|Deltaproteobacteria,43SPP@69541|Desulfuromonadales 28221|Deltaproteobacteria L AAA domain sbcC-1 - - - - - - - - - - - AAA_23 CMS1_k127_2102753_2 404380.Gbem_0250 1.262e-49 201.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,HEAT_PBS CMS1_k127_2102753_0 1379698.RBG1_1C00001G0230 3.288e-89 319.0 COG2206@1|root,COG2206@2|Bacteria,2NPP4@2323|unclassified Bacteria 2|Bacteria T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD CMS1_k127_2102753_1 1237149.C900_05249 3.036e-68 245.0 COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,47PK1@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA,PD40 CMS1_k127_2102753_5 1125863.JAFN01000001_gene850 1.777e-07 56.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07714,ko:K07715 ko02020,ko02024,map02020,map02024 M00500,M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_2104946_6 1121100.JCM6294_724 8.622e-09 64.0 COG4372@1|root,COG4372@2|Bacteria,4PBT4@976|Bacteroidetes,2FY9S@200643|Bacteroidia 976|Bacteroidetes S Transposase - - - - - - - - - - - - - CMS1_k127_2104946_1 1370121.AUWS01000024_gene2538 2.623e-144 494.0 COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae 201174|Actinobacteria K involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein pknK_2 - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - AAA_22,GerE,NB-ARC,Pkinase,TPR_12 CMS1_k127_2104946_3 309807.SRU_2711 5.187e-43 178.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,4NEW6@976|Bacteroidetes,1FJJN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes CO Disulphide bond corrector protein DsbC - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 CMS1_k127_2104946_2 856793.MICA_232 1.781e-65 230.0 COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,2U7PM@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA,Redoxin CMS1_k127_2104946_4 1430440.MGMSRv2_3545 1.064e-33 143.0 COG2227@1|root,COG2227@2|Bacteria,1NJ3M@1224|Proteobacteria,2VFV0@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Protein of unknown function (DUF1698) - - - - - - - - - - - - Methyltransf_11,Trm112p CMS1_k127_2104946_7 529818.AMSG_07828T0 7.681e-07 58.0 COG1793@1|root,KOG1037@1|root,KOG1037@2759|Eukaryota,KOG4437@2759|Eukaryota 2759|Eukaryota L base-excision repair, DNA ligation - GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0003950,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006464,GO:0006471,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016886,GO:0019538,GO:0033554,GO:0034641,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0070212,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901564 2.4.2.30,6.5.1.1 ko:K10776,ko:K10798 ko03410,ko04210,ko04212,ko04214,ko04217,map03410,map04210,map04212,map04214,map04217 M00296 R00381 RC00005 ko00000,ko00001,ko00002,ko01000,ko03032,ko03036,ko03400 - - - BRCT,DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N,PADR1,PARP,PARP_reg,WGR,zf-PARP CMS1_k127_2104946_0 1254432.SCE1572_13050 1.331e-180 584.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 CMS1_k127_2104946_5 1519464.HY22_06660 1.469e-18 90.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - FlgD_ig,MAM,Sortilin-Vps10,TIG,fn3 CMS1_k127_2113117_5 1095769.CAHF01000022_gene348 5.08e-43 176.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,2VNV5@28216|Betaproteobacteria,475N7@75682|Oxalobacteraceae 28216|Betaproteobacteria P Substrate binding domain of ABC-type glycine betaine transport system opuBC - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC CMS1_k127_2113117_4 309807.SRU_2473 2.196e-83 286.0 COG1125@1|root,COG1125@2|Bacteria,4NFE5@976|Bacteroidetes,1FJX5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E AAA ATPase domain - - - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - ABC_tran CMS1_k127_2113117_2 42256.RradSPS_1990 3.096e-147 486.0 COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria 201174|Actinobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family lpd_1 - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim CMS1_k127_2113117_1 926549.KI421517_gene1098 2.464e-241 760.0 COG3387@1|root,COG3387@2|Bacteria,4NEE6@976|Bacteroidetes,47MRU@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 CMS1_k127_2113117_0 234267.Acid_5940 1.428e-244 785.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2113117_3 886293.Sinac_4689 6.899e-86 296.0 COG1432@1|root,COG1432@2|Bacteria,2IY4C@203682|Planctomycetes 203682|Planctomycetes S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH CMS1_k127_2113117_6 1121015.N789_03890 4.893e-32 134.0 COG0406@1|root,COG0406@2|Bacteria 2|Bacteria G alpha-ribazole phosphatase activity yrgI - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 CMS1_k127_2118208_0 1121468.AUBR01000022_gene2786 2.717e-118 392.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,42ERB@68295|Thermoanaerobacterales 186801|Clostridia J TIGRFAM Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d CMS1_k127_2118208_2 1144275.COCOR_04284 1.74e-84 304.0 COG0524@1|root,COG0524@2|Bacteria,1Q8Y3@1224|Proteobacteria,42NSV@68525|delta/epsilon subdivisions,2WJWD@28221|Deltaproteobacteria,2YU0F@29|Myxococcales 28221|Deltaproteobacteria G pfkB family carbohydrate kinase - - - - - - - - - - - iAF987.Gmet_2683 PfkB CMS1_k127_2118208_4 555088.DealDRAFT_1143 8.031e-64 238.0 COG2206@1|root,COG2206@2|Bacteria,1UJ0B@1239|Firmicutes,25ESZ@186801|Clostridia,42KJX@68298|Syntrophomonadaceae 186801|Clostridia T HD domain - - - - - - - - - - - - GAF_2,HD,HD_5,PAS,PAS_3,PAS_4 CMS1_k127_2118208_1 264732.Moth_2046 1.236e-98 338.0 COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,42EPI@68295|Thermoanaerobacterales 186801|Clostridia F PFAM AIR synthase related protein purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS1_k127_2118208_3 290397.Adeh_0417 9.576e-76 278.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YX5F@29|Myxococcales 28221|Deltaproteobacteria T response regulator nla19 - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_2118208_5 379066.GAU_1177 6.076e-28 116.0 COG0673@1|root,COG0673@2|Bacteria,1ZSV9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Homoserine dehydrogenase, NAD binding domain - - - - - - - - - - - - GFO_IDH_MocA CMS1_k127_2130779_9 68199.JNZO01000010_gene6327 0.0002928 51.0 COG5592@1|root,COG5592@2|Bacteria,2HF5Y@201174|Actinobacteria 201174|Actinobacteria S hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin CMS1_k127_2130779_5 340177.Cag_0901 3.301e-40 159.0 COG0698@1|root,COG0698@2|Bacteria,1FDZN@1090|Chlorobi 1090|Chlorobi G TIGRFAM sugar-phosphate isomerase, RpiB LacA LacB family - - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB CMS1_k127_2130779_1 1382306.JNIM01000001_gene766 1.801e-143 476.0 COG0166@1|root,COG0166@2|Bacteria,2G67J@200795|Chloroflexi 200795|Chloroflexi G Belongs to the GPI family pgi - 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI,TAL_FSA CMS1_k127_2130779_7 95619.PM1_0226330 1.815e-17 92.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent protease - - - - - - - - - - - - Peptidase_M48 CMS1_k127_2130779_8 1151122.AQYD01000007_gene1021 2.267e-06 61.0 COG2764@1|root,COG2764@2|Bacteria,2I7IT@201174|Actinobacteria,4FSQ6@85023|Microbacteriaceae 201174|Actinobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase CMS1_k127_2130779_3 113395.AXAI01000012_gene7096 1.641e-100 340.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,3JR2T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI,TAL_FSA CMS1_k127_2130779_2 309801.trd_1142 1.376e-119 391.0 COG1023@1|root,COG1023@2|Bacteria,2G5YD@200795|Chloroflexi,27XH5@189775|Thermomicrobia 189775|Thermomicrobia C 6-phosphogluconate dehydrogenase, C-terminal domain - - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 CMS1_k127_2130779_0 357808.RoseRS_2562 3.567e-181 592.0 COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia 32061|Chloroflexia G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N CMS1_k127_2130779_6 357808.RoseRS_2561 5.613e-19 102.0 COG3429@1|root,COG3429@2|Bacteria,2G6ZV@200795|Chloroflexi,375YF@32061|Chloroflexia 32061|Chloroflexia G Glucose-6-phosphate dehydrogenase subunit - - - - - - - - - - - - OpcA_G6PD_assem CMS1_k127_2130779_4 404380.Gbem_2002 1.316e-62 232.0 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,42QTP@68525|delta/epsilon subdivisions,2WN6N@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase CMS1_k127_2135680_2 348824.LPU83_4142 3.007e-19 102.0 COG3832@1|root,COG3832@2|Bacteria,1RC0V@1224|Proteobacteria,2TS70@28211|Alphaproteobacteria,4BE5R@82115|Rhizobiaceae 28211|Alphaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 CMS1_k127_2135680_1 582402.Hbal_0106 3.706e-24 105.0 COG0640@1|root,COG0640@2|Bacteria,1N7IV@1224|Proteobacteria,2UIB6@28211|Alphaproteobacteria,440QE@69657|Hyphomonadaceae 28211|Alphaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 CMS1_k127_2135680_0 1050202.KB913024_gene3135 6.797e-70 246.0 COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,407ZE@622450|Actinopolysporales 201174|Actinobacteria P Sodium:sulfate symporter transmembrane region sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp CMS1_k127_2135703_1 349161.Dred_1947 4.377e-25 114.0 COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,260B8@186807|Peptococcaceae 186801|Clostridia S Belongs to the peptidase M16 family ymxG - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_2135703_3 1347086.CCBA010000003_gene3882 4.378e-08 56.0 COG3526@1|root,COG3526@2|Bacteria,1VKFI@1239|Firmicutes,4HR9S@91061|Bacilli 91061|Bacilli O Rdx family - - - ko:K07401 - - - - ko00000 - - - Rdx CMS1_k127_2135703_0 880073.Calab_0634 7.199e-61 241.0 COG0308@1|root,COG0308@2|Bacteria,2NPPZ@2323|unclassified Bacteria 2|Bacteria E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 CMS1_k127_2135703_2 1042376.AFPK01000040_gene2112 5.94e-10 62.0 COG0621@1|root,COG0621@2|Bacteria,4NDU6@976|Bacteroidetes,1HX6T@117743|Flavobacteriia,4064X@61432|unclassified Flavobacteriaceae 976|Bacteroidetes J TRAM domain miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 CMS1_k127_2140949_3 269799.Gmet_3342 9.689e-24 103.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M CMS1_k127_2140949_0 926560.KE387023_gene2306 6.571e-144 467.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine cefD - 5.1.1.17 ko:K04127,ko:K11325,ko:K21174 ko00311,ko01059,ko01100,ko01130,map00311,map01059,map01100,map01130 M00673,M00825 R04147 RC00302 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 CMS1_k127_2140949_2 945713.IALB_2073 1.398e-24 116.0 2F7PM@1|root,34042@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_2140949_1 459349.CLOAM1245 2.985e-99 333.0 COG0436@1|root,COG0436@2|Bacteria,2NP0E@2323|unclassified Bacteria 2|Bacteria E Aminotransferase class I and II aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS10450 Aminotran_1_2 CMS1_k127_2154194_0 1198114.AciX9_2489 1.837e-27 125.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity wcoG - - - - - - - - - - - DUF5122,Laminin_G_3,PKD CMS1_k127_2154194_2 459349.CLOAM0871 0.000336 52.0 COG2843@1|root,COG3291@1|root,COG2843@2|Bacteria,COG3291@2|Bacteria,2NPJI@2323|unclassified Bacteria 2|Bacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap,PKD,Peptidase_M15_4 CMS1_k127_2154194_1 1519464.HY22_10145 0.0002882 52.0 28P5X@1|root,2ZC0S@2|Bacteria 2|Bacteria - - - - - ko:K20326 ko02024,map02024 - - - ko00000,ko00001 - - - - CMS1_k127_2155777_0 452637.Oter_0928 3.927e-61 226.0 COG2829@1|root,COG2829@2|Bacteria,46XUQ@74201|Verrucomicrobia,3K8AI@414999|Opitutae 414999|Opitutae M Phospholipase A1 - - - - - - - - - - - - PLA1 CMS1_k127_2155777_1 290397.Adeh_3561 4.078e-53 200.0 COG0582@1|root,COG0582@2|Bacteria,1N45B@1224|Proteobacteria,42TJC@68525|delta/epsilon subdivisions,2WQY6@28221|Deltaproteobacteria,2Z31N@29|Myxococcales 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase CMS1_k127_2155777_2 443143.GM18_0616 7.022e-50 193.0 COG4346@1|root,COG4346@2|Bacteria 2|Bacteria O Dolichyl-phosphate-mannose-protein mannosyltransferase - - 2.4.1.109 ko:K00728 ko00514,ko00515,ko01100,map00514,map00515,map01100 - R04072,R07620,R11399 RC00005,RC00059,RC00397 ko00000,ko00001,ko01000,ko01003 - GT39 - GT87,PMT,PMT_2,PMT_4TMC CMS1_k127_2161296_1 478741.JAFS01000001_gene2221 6.808e-08 65.0 COG5652@1|root,COG5652@2|Bacteria,46Z0R@74201|Verrucomicrobia,37GZJ@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S VanZ like family - - - - - - - - - - - - VanZ CMS1_k127_2161296_0 880073.Calab_2940 8.258e-179 569.0 COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria 2|Bacteria E Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.11,4.4.1.8 ko:K01760,ko:K01761 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00654,R00782,R01286,R02408,R04770,R04941 RC00056,RC00069,RC00196,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP CMS1_k127_2161296_2 1280954.HPO_16975 0.0001222 46.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,2TUU6@28211|Alphaproteobacteria,43X3G@69657|Hyphomonadaceae 28211|Alphaproteobacteria QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_2165349_2 1379698.RBG1_1C00001G0991 7.854e-13 80.0 COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria 2|Bacteria Q FlgD Ig-like domain - - 3.2.1.136 ko:K15924 - - - - ko00000,ko01000 - GH5 - CBM_3,DUF1735,Laminin_G_3 CMS1_k127_2165349_1 324602.Caur_3541 1.002e-35 157.0 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - Arylsulfotran_2,Arylsulfotrans CMS1_k127_2165349_3 290397.Adeh_0921 0.0002346 53.0 COG2864@1|root,COG2864@2|Bacteria,1R5NK@1224|Proteobacteria,43CBZ@68525|delta/epsilon subdivisions,2X7MV@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Ethylbenzene dehydrogenase - - - - - - - - - - - - EB_dh CMS1_k127_2165349_0 880073.Calab_3297 5.474e-73 278.0 COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria 2|Bacteria P COGs COG1629 Outer membrane receptor protein mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS1_k127_21689_2 1205908.AKXW01000092_gene2399 7.04e-43 160.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - Cupin_2,NeuB CMS1_k127_21689_0 1122603.ATVI01000005_gene3841 2.58e-129 424.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1S5XF@1236|Gammaproteobacteria,1X4HJ@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - - - - - - - - - - - His_kinase CMS1_k127_21689_1 1123073.KB899241_gene2875 4.308e-108 368.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1SYRB@1236|Gammaproteobacteria,1XCSU@135614|Xanthomonadales 135614|Xanthomonadales KT Transcriptional regulator - - - - - - - - - - - - LytTR,Response_reg CMS1_k127_21689_4 1161401.ASJA01000006_gene1889 4.216e-28 122.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,43W9P@69657|Hyphomonadaceae 28211|Alphaproteobacteria O M13 family peptidase - - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N CMS1_k127_2199183_0 1192034.CAP_3089 9.49e-08 65.0 COG0402@1|root,COG2374@1|root,COG0402@2|Bacteria,COG2374@2|Bacteria,1NFUA@1224|Proteobacteria,433MB@68525|delta/epsilon subdivisions,2WXJF@28221|Deltaproteobacteria,2YUGP@29|Myxococcales 28221|Deltaproteobacteria F Lamin Tail Domain - - - - - - - - - - - - Amidohydro_1,DUF4215,LTD,TSP_3 CMS1_k127_2214578_0 1379698.RBG1_1C00001G1160 1.775e-167 540.0 COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria 2|Bacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 CMS1_k127_2214578_2 269799.Gmet_1590 2.461e-31 128.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria,43V8I@69541|Desulfuromonadales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 CMS1_k127_2214578_1 309801.trd_0769 3.339e-43 168.0 COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi,27XW5@189775|Thermomicrobia 189775|Thermomicrobia H Riboflavin kinase - - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase CMS1_k127_2216777_4 861299.J421_3347 1.58e-58 205.0 COG2185@1|root,COG2185@2|Bacteria,1ZTNN@142182|Gemmatimonadetes 142182|Gemmatimonadetes I B12 binding domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding CMS1_k127_2216777_2 1111479.AXAR01000003_gene1517 6.472e-101 339.0 COG1788@1|root,COG1788@2|Bacteria,1V21Q@1239|Firmicutes,4HB3E@91061|Bacilli,279JQ@186823|Alicyclobacillaceae 91061|Bacilli I Coenzyme A transferase scoA - 2.8.3.5 ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans CMS1_k127_2216777_3 1068980.ARVW01000001_gene7210 3.564e-84 284.0 COG2057@1|root,COG2057@2|Bacteria,2GKV9@201174|Actinobacteria,4DXIW@85010|Pseudonocardiales 201174|Actinobacteria I PFAM Coenzyme A transferase scoB - 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans CMS1_k127_2216777_1 292459.STH1571 1.04e-141 460.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia 186801|Clostridia C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_2216777_0 1379698.RBG1_1C00001G1459 1.78e-159 514.0 COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria 2|Bacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_2216777_5 1218076.BAYB01000036_gene5424 3.081e-14 85.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VGZU@28216|Betaproteobacteria,1K0VY@119060|Burkholderiaceae 28216|Betaproteobacteria I Dehydrogenase paaH1 - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N CMS1_k127_2223429_0 1144275.COCOR_07662 1.966e-127 426.0 COG0308@1|root,COG1668@1|root,COG0308@2|Bacteria,COG1668@2|Bacteria,1PTWJ@1224|Proteobacteria 1224|Proteobacteria E Peptidase family M1 domain - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,Peptidase_M1 CMS1_k127_2249550_0 1121468.AUBR01000001_gene512 6.277e-169 557.0 COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,42EVP@68295|Thermoanaerobacterales 186801|Clostridia C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - Radical_SAM CMS1_k127_22512_2 309807.SRU_p0003 0.0005653 51.0 COG3291@1|root,COG4733@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria,4PHV3@976|Bacteroidetes,1FK10@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Fibronectin type 3 domain - - - - - - - - - - - - - CMS1_k127_22512_0 404589.Anae109_2428 1.873e-28 121.0 COG3945@1|root,COG3945@2|Bacteria,1NG3G@1224|Proteobacteria,42WHU@68525|delta/epsilon subdivisions,2WRK5@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Hemerythrin HHE cation binding domain protein - - - - - - - - - - - - Hemerythrin CMS1_k127_22512_1 1340493.JNIF01000003_gene4475 8.518e-06 51.0 COG2318@1|root,COG2318@2|Bacteria,3Y8H7@57723|Acidobacteria 57723|Acidobacteria S DinB family - - - - - - - - - - - - DinB CMS1_k127_2271994_1 504832.OCAR_4758 3.745e-17 81.0 COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,3JYUE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1428) - - - - - - - - - - - - DUF1428 CMS1_k127_2271994_0 234267.Acid_5940 1.754e-227 733.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2271994_2 497964.CfE428DRAFT_6444 4.199e-10 61.0 COG3832@1|root,COG3832@2|Bacteria,46WBY@74201|Verrucomicrobia 74201|Verrucomicrobia S PFAM Activator of Hsp90 ATPase 1 family protein - - - - - - - - - - - - AHSA1 CMS1_k127_2287161_1 247490.KSU1_C0449 7.654e-74 265.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - Cadherin_3,DUF4347,Peptidase_S8 CMS1_k127_2287161_3 880073.Calab_3215 6.303e-16 91.0 COG0366@1|root,COG0708@1|root,COG0366@2|Bacteria,COG0708@2|Bacteria,2NREA@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolase family 70 - - 3.1.11.2,3.2.1.1 ko:K01142,ko:K01176 ko00500,ko01100,ko03410,ko04973,map00500,map01100,map03410,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000,ko03400 - GH13 - Alpha-amylase,CBM_25,DUF1939,He_PIG CMS1_k127_2287161_0 309799.DICTH_0538 1.206e-141 461.0 COG0156@1|root,COG0156@2|Bacteria 2|Bacteria E 8-amino-7-oxononanoate synthase activity bioF GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_2287161_2 1449346.JQMO01000002_gene1630 2.953e-55 200.0 COG0454@1|root,COG0456@2|Bacteria,2GNAV@201174|Actinobacteria 201174|Actinobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_2299674_0 1415780.JPOG01000001_gene275 1.677e-137 451.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1X45Q@135614|Xanthomonadales 135614|Xanthomonadales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran CMS1_k127_2318149_4 1379698.RBG1_1C00001G1766 9.469e-22 104.0 COG4365@1|root,COG4365@2|Bacteria,2NP8Q@2323|unclassified Bacteria 2|Bacteria S Bacillithiol biosynthesis BshC bshC - - ko:K22136 - - - - ko00000 - - - BshC CMS1_k127_2318149_0 401053.AciPR4_3379 3.338e-121 411.0 COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria,2JKK7@204432|Acidobacteriia 204432|Acidobacteriia M glycosyl transferase group 1 - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 CMS1_k127_2318149_1 1379698.RBG1_1C00001G1216 1.237e-74 270.0 COG0407@1|root,COG0407@2|Bacteria,2NPIC@2323|unclassified Bacteria 2|Bacteria H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D CMS1_k127_2318149_2 1121472.AQWN01000004_gene779 7.937e-40 165.0 COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,26265@186807|Peptococcaceae 186801|Clostridia H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox CMS1_k127_2318149_3 322710.Avin_05730 1.924e-30 129.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Membrane-bound serine protease (ClpP class) nfeD - - ko:K07403 - - - - ko00000 - - - NfeD CMS1_k127_2319470_2 290397.Adeh_2194 6.144e-15 76.0 COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2WPT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm,ResB CMS1_k127_2319470_0 1123368.AUIS01000024_gene950 3.352e-155 509.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS1_k127_2319470_1 1123368.AUIS01000024_gene949 5.492e-100 330.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,2NBU9@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS1_k127_2321132_0 404589.Anae109_3842 9.664e-123 410.0 COG1164@1|root,COG1164@2|Bacteria,1Q3C4@1224|Proteobacteria,4393F@68525|delta/epsilon subdivisions,2X49B@28221|Deltaproteobacteria,2YYJ7@29|Myxococcales 28221|Deltaproteobacteria E Oligoendopeptidase f - - - - - - - - - - - - - CMS1_k127_2321132_1 1279009.ADICEAN_01016 5.414e-21 96.0 COG4319@1|root,COG4319@2|Bacteria,4NTMK@976|Bacteroidetes,47X83@768503|Cytophagia 976|Bacteroidetes S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS1_k127_2334568_7 1096930.L284_12160 3.721e-06 52.0 COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2U187@28211|Alphaproteobacteria,2K0N5@204457|Sphingomonadales 204457|Sphingomonadales S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS1_k127_2334568_4 269799.Gmet_2367 2.998e-73 267.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,43TVN@69541|Desulfuromonadales 28221|Deltaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase CMS1_k127_2334568_6 330214.NIDE2973 5.869e-44 175.0 COG0101@1|root,COG0101@2|Bacteria,3J0PM@40117|Nitrospirae 40117|Nitrospirae J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 CMS1_k127_2334568_3 379066.GAU_1730 4.05e-79 282.0 COG0265@1|root,COG0265@2|Bacteria,1ZTAM@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS1_k127_2334568_1 644966.Tmar_1426 5.164e-150 487.0 COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,3WCKG@538999|Clostridiales incertae sedis 186801|Clostridia F Adenylosuccinate lyase C-terminus purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 CMS1_k127_2334568_0 1094715.CM001373_gene3313 2.823e-179 588.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1JDPB@118969|Legionellales 118969|Legionellales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS1_k127_2334568_5 1094715.CM001373_gene3315 3.311e-48 192.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,1SVID@1236|Gammaproteobacteria,1JD85@118969|Legionellales 118969|Legionellales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 CMS1_k127_2334568_2 1207063.P24_04070 3.001e-83 289.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,2JPC6@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran CMS1_k127_2351627_5 1499680.CCFE01000031_gene3716 3.214e-06 49.0 COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,4H9QD@91061|Bacilli,1ZB4U@1386|Bacillus 91061|Bacilli E Belongs to the carbamate kinase family cpkA - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase CMS1_k127_2351627_2 883103.HMPREF9703_01094 3.474e-41 171.0 COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,4HVSH@91061|Bacilli,27FKR@186828|Carnobacteriaceae 91061|Bacilli S ATPases associated with a variety of cellular activities mglA - 3.6.3.17 ko:K02056,ko:K06400 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran CMS1_k127_2351627_3 861299.J421_1178 2.935e-16 94.0 COG4603@1|root,COG4603@2|Bacteria,1ZTGR@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 CMS1_k127_2351627_4 1121930.AQXG01000001_gene1125 1.863e-08 64.0 COG0737@1|root,COG1506@1|root,COG0737@2|Bacteria,COG1506@2|Bacteria,4NQQD@976|Bacteroidetes 976|Bacteroidetes E Lamin Tail Domain - - - - - - - - - - - - Calx-beta,LTD CMS1_k127_2351627_1 338969.Rfer_4025 1.522e-54 218.0 COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2VSH3@28216|Betaproteobacteria,4AEBC@80864|Comamonadaceae 28216|Betaproteobacteria S YCII-related domain - - - - - - - - - - - - YCII CMS1_k127_2351627_0 84531.JMTZ01000097_gene501 2.987e-75 257.0 COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,1RN25@1236|Gammaproteobacteria,1X30Y@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2357396_1 1304275.C41B8_13220 1.728e-43 165.0 2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,1SP3W@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_2357396_0 1157490.EL26_15905 3.744e-173 572.0 COG0855@1|root,COG0855@2|Bacteria,1TNZM@1239|Firmicutes,4HA88@91061|Bacilli,279B6@186823|Alicyclobacillaceae 91061|Bacilli P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N CMS1_k127_2412459_2 646529.Desaci_1209 1.682e-150 497.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,260F2@186807|Peptococcaceae 186801|Clostridia L PFAM UvrD REP helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C CMS1_k127_2412459_4 1173025.GEI7407_1292 7.213e-17 83.0 COG0721@1|root,COG0721@2|Bacteria,1G7N8@1117|Cyanobacteria,1HC33@1150|Oscillatoriales 1117|Cyanobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln CMS1_k127_2412459_0 1210884.HG799462_gene8721 5.682e-167 539.0 COG0154@1|root,COG0154@2|Bacteria,2IXW5@203682|Planctomycetes 203682|Planctomycetes J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase CMS1_k127_2412459_1 639282.DEFDS_1934 1.276e-161 535.0 COG0064@1|root,COG0064@2|Bacteria,2GF45@200930|Deferribacteres 200930|Deferribacteres J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey CMS1_k127_2412459_3 1120985.AUMI01000017_gene2679 1.348e-87 318.0 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,4H1YR@909932|Negativicutes 909932|Negativicutes F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N CMS1_k127_24125_2 1392490.JHZX01000001_gene689 8.039e-05 50.0 COG4244@1|root,COG4244@2|Bacteria,4NPYK@976|Bacteroidetes,1I23E@117743|Flavobacteriia 976|Bacteroidetes S Predicted membrane protein (DUF2231) - - - - - - - - - - - - DUF2231 CMS1_k127_24125_0 497964.CfE428DRAFT_1990 6.043e-129 429.0 COG0665@1|root,COG0665@2|Bacteria,46TXP@74201|Verrucomicrobia 74201|Verrucomicrobia E FAD dependent oxidoreductase - - - - - - - - - - - - DAO CMS1_k127_24125_1 1183438.GKIL_2106 3.677e-42 171.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - CBM_2 CMS1_k127_2430443_1 251221.35211731 5.547e-73 249.0 COG1063@1|root,COG1063@2|Bacteria 2|Bacteria E alcohol dehydrogenase gcd - - - - - - - - - - - ADH_N,ADH_zinc_N,Glu_dehyd_C CMS1_k127_2430443_0 1496688.ER33_11555 3.498e-137 460.0 COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,22THV@167375|Cyanobium 1117|Cyanobacteria G Amylo-alpha-1,6-glucosidase - - - - - - - - - - - - GDE_C,GDE_N CMS1_k127_2453465_2 493475.GARC_2783 2.432e-51 184.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,468D5@72275|Alteromonadaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_2453465_0 1123073.KB899241_gene2287 2.011e-126 415.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X7MH@135614|Xanthomonadales 135614|Xanthomonadales E Glycine cleavage T-protein C-terminal barrel domain - - - - - - - - - - - - GCV_T,GCV_T_C CMS1_k127_2453465_1 204669.Acid345_1270 4.813e-108 363.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 CMS1_k127_2458363_1 994573.T472_0209920 9.603e-19 87.0 COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,36JKP@31979|Clostridiaceae 186801|Clostridia D Could be involved in septation spoVG - - ko:K06412 - - - - ko00000 - - - SpoVG CMS1_k127_2458363_0 1379698.RBG1_1C00001G0643 8.189e-111 369.0 COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria 2|Bacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N CMS1_k127_2514315_0 204669.Acid345_3980 1.829e-75 276.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_8 CMS1_k127_2514315_5 1550091.JROE01000004_gene1329 9.998e-05 48.0 COG0345@1|root,COG0345@2|Bacteria,4NE6F@976|Bacteroidetes,1IR2E@117747|Sphingobacteriia 976|Bacteroidetes E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer CMS1_k127_2514315_3 1545915.JROG01000009_gene2862 7.526e-17 87.0 COG1695@1|root,COG1695@2|Bacteria,1PCI9@1224|Proteobacteria,2V1YM@28211|Alphaproteobacteria,2KC7X@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS1_k127_2514315_2 204669.Acid345_2449 4.074e-39 160.0 COG3577@1|root,COG3577@2|Bacteria,3Y90B@57723|Acidobacteria,2JNTZ@204432|Acidobacteriia 204432|Acidobacteriia S Aspartyl protease - - - - - - - - - - - - Asp_protease_2 CMS1_k127_2514315_1 289376.THEYE_A0098 2.165e-58 211.0 COG0681@1|root,COG0681@2|Bacteria,3J0IP@40117|Nitrospirae 40117|Nitrospirae U Signal peptidase, peptidase S26 lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 CMS1_k127_2514315_4 1094980.Mpsy_0731 4.027e-13 82.0 arCOG06534@1|root,arCOG06534@2157|Archaea,2Y2GI@28890|Euryarchaeota,2NAF1@224756|Methanomicrobia 224756|Methanomicrobia S Putative Ig domain - - - - - - - - - - - - He_PIG CMS1_k127_2543107_0 324602.Caur_1894 1.377e-218 687.0 COG2317@1|root,COG2317@2|Bacteria,2G7UQ@200795|Chloroflexi,37518@32061|Chloroflexia 32061|Chloroflexia E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 CMS1_k127_2543107_1 309807.SRU_0797 2.711e-33 134.0 COG1670@1|root,COG1670@2|Bacteria,4NQB5@976|Bacteroidetes 976|Bacteroidetes J acetyltransferase, GNAT family - - - - - - - - - - - - Acetyltransf_10,Acetyltransf_3 CMS1_k127_2548693_3 478741.JAFS01000002_gene410 1.291e-08 61.0 2CK2Q@1|root,329IJ@2|Bacteria,46ZCM@74201|Verrucomicrobia,37GU0@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - CMS1_k127_2548693_0 479434.Sthe_1958 1.164e-66 244.0 COG0500@1|root,COG2226@2|Bacteria,2G6R0@200795|Chloroflexi,27Z68@189775|Thermomicrobia 189775|Thermomicrobia Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 CMS1_k127_2548693_1 365046.Rta_09260 6.132e-11 72.0 COG2944@1|root,COG2944@2|Bacteria,1N21E@1224|Proteobacteria,2VUAS@28216|Betaproteobacteria,4AF56@80864|Comamonadaceae 28216|Betaproteobacteria K Helix-turn-helix domain protein - - - - - - - - - - - - HTH_3,HTH_31 CMS1_k127_2548693_2 399741.Spro_3378 1.617e-09 61.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,401SG@613|Serratia 1236|Gammaproteobacteria I Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities fadJ GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,ic_1306.c2886 3HCDH,3HCDH_N,ECH_1 CMS1_k127_2579449_0 880073.Calab_0921 1.091e-12 81.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF4157,FctA,Peptidase_M43 CMS1_k127_2579449_2 1453500.AT05_09365 1.947e-07 64.0 COG3209@1|root,COG3209@2|Bacteria,4P5ZD@976|Bacteroidetes 976|Bacteroidetes M COG3209 Rhs family protein - - - - - - - - - - - - - CMS1_k127_2579449_1 880073.Calab_2400 2.068e-08 66.0 2E2T1@1|root,32XVB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_2621594_1 880073.Calab_0696 2.404e-12 80.0 COG1262@1|root,COG2911@1|root,COG3055@1|root,COG3934@1|root,COG5492@1|root,COG1262@2|Bacteria,COG2911@2|Bacteria,COG3055@2|Bacteria,COG3934@2|Bacteria,COG5492@2|Bacteria,2NPU7@2323|unclassified Bacteria 2|Bacteria G Sulfatase-modifying factor enzyme 1 - - 3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89 ko:K01176,ko:K01206,ko:K01218,ko:K01219,ko:K01224 ko00051,ko00500,ko00511,ko01100,ko02024,ko04973,map00051,map00500,map00511,map01100,map02024,map04973 - R01332,R02108,R02112,R11262 RC00467 ko00000,ko00001,ko01000,ko04147 - GH13,GH26,GH29 - Big_2,DctA-YdbH,FGE-sulfatase CMS1_k127_2621594_0 215803.DB30_5098 1.498e-108 367.0 COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,42UR5@68525|delta/epsilon subdivisions,2WQET@28221|Deltaproteobacteria,2YU27@29|Myxococcales 28221|Deltaproteobacteria G Belongs to the glycosyl hydrolase 1 family - - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1 CMS1_k127_262382_0 909663.KI867150_gene2923 3.837e-47 180.0 COG2129@1|root,COG2129@2|Bacteria,1PU6K@1224|Proteobacteria,42VJG@68525|delta/epsilon subdivisions,2WRD6@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Calcineurin-like phosphoesterase - - - ko:K07096 - - - - ko00000 - - - Metallophos CMS1_k127_262382_1 1267533.KB906734_gene4323 1.646e-44 166.0 COG0341@1|root,COG0341@2|Bacteria,3Y2ZT@57723|Acidobacteria,2JHZF@204432|Acidobacteriia 204432|Acidobacteriia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS1_k127_262627_0 313606.M23134_00255 1.435e-76 278.0 COG3291@1|root,COG3291@2|Bacteria,4PKTY@976|Bacteroidetes,47RAA@768503|Cytophagia 976|Bacteroidetes M ASPIC and UnbV - - - - - - - - - - - - PKD,UnbV_ASPIC,VCBS CMS1_k127_262627_2 1089550.ATTH01000001_gene1072 3.869e-11 76.0 COG1409@1|root,COG1572@1|root,COG4733@1|root,COG1409@2|Bacteria,COG1572@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - 3.2.1.4,3.4.21.96 ko:K01179,ko:K01361,ko:K13277,ko:K21449 ko00500,ko01100,ko02024,map00500,map01100,map02024 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko01002,ko02000,ko03110 1.B.40.2 GH5,GH9 - Amidase_2,DUF1735,Glucosaminidase,Laminin_G_3 CMS1_k127_262627_1 1121904.ARBP01000007_gene3069 2.574e-23 110.0 COG1629@1|root,COG4771@2|Bacteria,4NFKZ@976|Bacteroidetes,47NS4@768503|Cytophagia 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec CMS1_k127_264141_2 266117.Rxyl_0084 2.228e-44 168.0 COG0428@1|root,COG0428@2|Bacteria,2ICIQ@201174|Actinobacteria,4CSVK@84995|Rubrobacteria 84995|Rubrobacteria P Mediates zinc uptake. May also transport other divalent cations - - - - - - - - - - - - - CMS1_k127_264141_3 102125.Xen7305DRAFT_00002270 1.762e-43 171.0 COG0398@1|root,COG0398@2|Bacteria,1G3R9@1117|Cyanobacteria,3VM6G@52604|Pleurocapsales 1117|Cyanobacteria S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 CMS1_k127_264141_0 1121430.JMLG01000002_gene1235 5.554e-89 324.0 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,260QJ@186807|Peptococcaceae 186801|Clostridia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran CMS1_k127_264141_1 1232410.KI421416_gene2620 3.786e-60 228.0 COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,42N8F@68525|delta/epsilon subdivisions,2WK3B@28221|Deltaproteobacteria,43U4Y@69541|Desulfuromonadales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane CMS1_k127_2641437_1 1121405.dsmv_3764 4.214e-40 154.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2MHW2@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr CMS1_k127_2641437_2 1249627.D779_1049 0.0006645 53.0 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WXZE@135613|Chromatiales 135613|Chromatiales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - 7TMR-DISM_7TM,GGDEF,HAMP,HATPase_c,HisKA,Response_reg CMS1_k127_2641437_0 1121430.JMLG01000002_gene1011 8.425e-205 661.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,260BY@186807|Peptococcaceae 186801|Clostridia O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C CMS1_k127_2656491_5 1379698.RBG1_1C00001G1143 5.131e-05 46.0 COG0776@1|root,COG0776@2|Bacteria,2NPU6@2323|unclassified Bacteria 2|Bacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup_1 - - ko:K03530,ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS1_k127_2656491_1 292459.STH1114 6.843e-64 231.0 COG1015@1|root,COG1015@2|Bacteria,1UJAM@1239|Firmicutes,25EZP@186801|Clostridia 186801|Clostridia C Metalloenzyme superfamily - - - - - - - - - - - - Metalloenzyme CMS1_k127_2656491_3 1507.HMPREF0262_01119 1.849e-08 66.0 COG0760@1|root,COG0760@2|Bacteria,1VE2Y@1239|Firmicutes 1239|Firmicutes M PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_3,SurA_N_3 CMS1_k127_2656491_0 56780.SYN_01184 2.292e-69 249.0 COG1945@1|root,COG1945@2|Bacteria,1RE9E@1224|Proteobacteria,42RQ0@68525|delta/epsilon subdivisions,2WNKW@28221|Deltaproteobacteria,2MRSR@213462|Syntrophobacterales 28221|Deltaproteobacteria S Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) - - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC CMS1_k127_2656491_4 1047013.AQSP01000122_gene2254 1.471e-06 58.0 COG4856@1|root,COG4856@2|Bacteria 2|Bacteria O YbbR-like protein dacA - - - - - - - - - - - YbbR CMS1_k127_2656491_2 368407.Memar_0653 7.206e-15 83.0 COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,2N9M2@224756|Methanomicrobia 224756|Methanomicrobia L 8-oxoguanine DNA glycosylase domain protein - - 4.2.99.18 ko:K03660 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD,OGG_N CMS1_k127_2702508_0 1231185.BAMP01000010_gene1984 1.138e-40 154.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2TS1B@28211|Alphaproteobacteria,43JQ0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Glutathione S-transferase gstch1 - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 CMS1_k127_2702508_1 1242864.D187_004231 3.183e-34 150.0 COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria,42QHC@68525|delta/epsilon subdivisions,2WKUI@28221|Deltaproteobacteria 28221|Deltaproteobacteria DZ Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - - - - - - - - - - - RCC1 CMS1_k127_2704400_6 290397.Adeh_2353 1.874e-34 136.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WP23@28221|Deltaproteobacteria,2Z0GF@29|Myxococcales 28221|Deltaproteobacteria S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily yrdA - - - - - - - - - - - Hexapep CMS1_k127_2704400_7 1121918.ARWE01000001_gene3464 3.362e-06 59.0 COG0683@1|root,COG0683@2|Bacteria,1R8IG@1224|Proteobacteria,42N7H@68525|delta/epsilon subdivisions,2WIUQ@28221|Deltaproteobacteria,43S82@69541|Desulfuromonadales 28221|Deltaproteobacteria E LppC putative lipoprotein - - - ko:K07121 - - - - ko00000 - - - LppC,Peripla_BP_6,TPR_16,TPR_6 CMS1_k127_2704400_0 1379698.RBG1_1C00001G1351 2.244e-120 419.0 COG0683@1|root,COG0683@2|Bacteria,2NPSN@2323|unclassified Bacteria 2|Bacteria E Receptor family ligand binding region livJ - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 CMS1_k127_2704400_2 1379698.RBG1_1C00001G1350 2.452e-112 370.0 COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid transport system / permease component livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 CMS1_k127_2704400_3 1379698.RBG1_1C00001G1349 5.598e-112 370.0 COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria 2|Bacteria U Branched-chain amino acid transport system / permease component - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 CMS1_k127_2704400_4 644966.Tmar_0651 5.081e-94 316.0 COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,3WCU3@538999|Clostridiales incertae sedis 186801|Clostridia E Amino acid amide ABC transporter ATP-binding protein 1, HAAT family livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C CMS1_k127_2704400_5 1487923.DP73_10150 6.428e-84 298.0 COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,260MZ@186807|Peptococcaceae 186801|Clostridia E PFAM ABC transporter livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C CMS1_k127_2704400_1 1232410.KI421428_gene1195 9.216e-116 399.0 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,43S0Q@69541|Desulfuromonadales 28221|Deltaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA CMS1_k127_2722831_2 1348908.KI518641_gene1409 4.533e-08 55.0 COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,4HJ21@91061|Bacilli,1ZDSK@1386|Bacillus 91061|Bacilli J protein with SCP PR1 domains ykwD - - - - - - - - - - - CAP CMS1_k127_2722831_0 225937.HP15_3244 4.007e-68 241.0 COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,466G0@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09797 - - - - ko00000 - - - SIMPL CMS1_k127_2722831_1 1121918.ARWE01000001_gene1797 2.306e-27 130.0 COG1404@1|root,COG1404@2|Bacteria,1QYWU@1224|Proteobacteria,42VXP@68525|delta/epsilon subdivisions,2X7PK@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - CMS1_k127_2723523_0 1254432.SCE1572_28920 2.138e-101 333.0 COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2X9TY@28221|Deltaproteobacteria,2YV7W@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate ribA - 3.5.4.25 ko:K01497 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125 R00425 RC00293,RC02504 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydro2 CMS1_k127_2728416_0 1121468.AUBR01000009_gene2155 3.845e-59 220.0 COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,42GGH@68295|Thermoanaerobacterales 186801|Clostridia S SMART phosphoesterase PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP CMS1_k127_2728416_1 290397.Adeh_0651 4.977e-20 94.0 COG0457@1|root,COG0457@2|Bacteria,1R7RK@1224|Proteobacteria,42PPY@68525|delta/epsilon subdivisions,2WKX6@28221|Deltaproteobacteria,2YUCP@29|Myxococcales 28221|Deltaproteobacteria NU Tetratricopeptide repeats - - - - - - - - - - - - TPR_11,TPR_16,TPR_19 CMS1_k127_2734378_6 903818.KI912269_gene362 8.578e-13 75.0 COG0859@1|root,COG0859@2|Bacteria 2|Bacteria M ADP-heptose-lipopolysaccharide heptosyltransferase activity rfaQ - - ko:K02841,ko:K02843,ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 CMS1_k127_2734378_3 330214.NIDE3030 5.33e-41 171.0 COG0859@1|root,COG0859@2|Bacteria,3J0KI@40117|Nitrospirae 40117|Nitrospirae M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02841,ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 CMS1_k127_2734378_4 483219.LILAB_31475 7.245e-37 158.0 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose rfaE - - - - - - - - - - - CTP_transf_like CMS1_k127_2734378_1 401526.TcarDRAFT_1319 3.943e-58 228.0 COG2870@1|root,COG2870@2|Bacteria,1TSMF@1239|Firmicutes,4H1UR@909932|Negativicutes 909932|Negativicutes M Bifunctional protein rfaE - - - - - - - - - - - CTP_transf_like,PfkB CMS1_k127_2734378_0 518766.Rmar_1962 6.537e-101 353.0 COG0743@1|root,COG0743@2|Bacteria,4NG0S@976|Bacteroidetes,1FIKG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom CMS1_k127_2734378_2 945713.IALB_0622 4.181e-43 169.0 COG4589@1|root,COG4589@2|Bacteria 2|Bacteria S phosphatidate cytidylyltransferase activity cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 CMS1_k127_2734378_5 335541.Swol_0886 5.255e-20 89.0 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,42JSN@68298|Syntrophomonadaceae 186801|Clostridia H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf CMS1_k127_2739266_3 1419583.V466_21045 3.396e-50 190.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,1RQ4U@1236|Gammaproteobacteria,1YNI1@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria U Belongs to the GSP D family rcpA - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N CMS1_k127_2739266_5 1120985.AUMI01000014_gene1070 3.172e-24 119.0 COG4655@1|root,COG4655@2|Bacteria,1V25X@1239|Firmicutes,4H46N@909932|Negativicutes 909932|Negativicutes S Putative Flp pilus-assembly TadE/G-like - - - - - - - - - - - - Tad CMS1_k127_2739266_4 383372.Rcas_0422 2.32e-27 126.0 COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,2G6CH@200795|Chloroflexi,37524@32061|Chloroflexia 32061|Chloroflexia D PFAM response regulator receiver - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,Response_reg CMS1_k127_2739266_0 279714.FuraDRAFT_0828 3.923e-149 503.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,2KTWA@206351|Neisseriales 206351|Neisseriales U Type II/IV secretion system protein - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE CMS1_k127_2739266_1 1267533.KB906738_gene2057 1.293e-56 211.0 COG4965@1|root,COG4965@2|Bacteria,3Y4RR@57723|Acidobacteria,2JJ91@204432|Acidobacteriia 204432|Acidobacteriia U Type II secretion system - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF CMS1_k127_2739266_2 1121406.JAEX01000002_gene905 1.52e-53 200.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,42R2X@68525|delta/epsilon subdivisions,2WMU1@28221|Deltaproteobacteria,2MAZ8@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM Type II secretion system F - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF CMS1_k127_2739266_6 1382356.JQMP01000003_gene1783 3.435e-24 109.0 COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,27YI4@189775|Thermomicrobia 189775|Thermomicrobia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2740151_1 1112204.GPOL_c20100 2.562e-22 97.0 COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4GB3F@85026|Gordoniaceae 201174|Actinobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase CMS1_k127_2740151_0 1123072.AUDH01000038_gene152 2.717e-122 407.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U9M6@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 CMS1_k127_2741736_0 1254432.SCE1572_14045 3.066e-09 66.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,42PP6@68525|delta/epsilon subdivisions,2WJN2@28221|Deltaproteobacteria 28221|Deltaproteobacteria GM PFAM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 CMS1_k127_2741736_1 1297742.A176_05385 8.005e-09 69.0 COG4932@1|root,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,438GF@68525|delta/epsilon subdivisions,2X3RA@28221|Deltaproteobacteria,2YWWZ@29|Myxococcales 28221|Deltaproteobacteria M Bacterial Ig-like domain (group 1) - - - - - - - - - - - - Big_1,LTD CMS1_k127_2742334_0 380394.Lferr_1738 5.768e-246 788.0 COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,1T1IP@1236|Gammaproteobacteria,2NCIU@225057|Acidithiobacillales 225057|Acidithiobacillales G Alpha amylase, catalytic domain - - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase CMS1_k127_2742334_1 886293.Sinac_2834 1.164e-06 53.0 COG0296@1|root,COG0296@2|Bacteria,2IXPW@203682|Planctomycetes 203682|Planctomycetes G Alpha amylase, catalytic domain - - 3.2.1.1,3.2.1.141 ko:K01176,ko:K01236 ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973 M00565 R02108,R02112,R09995,R11256,R11262 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459,S6PP CMS1_k127_2744499_0 1267535.KB906767_gene5241 3.699e-147 489.0 COG3379@1|root,COG3379@2|Bacteria,3Y7EC@57723|Acidobacteria 57723|Acidobacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest CMS1_k127_2747870_0 404589.Anae109_0601 2.56e-119 393.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales 28221|Deltaproteobacteria K ATPase associated with various cellular activities, AAA_5 - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat CMS1_k127_2747870_1 278957.ABEA03000104_gene356 6.963e-71 254.0 COG0707@1|root,COG0707@2|Bacteria,46SRU@74201|Verrucomicrobia 74201|Verrucomicrobia M Monogalactosyldiacylglycerol (MGDG) synthase - - 2.4.1.315 ko:K03429 ko00561,ko01100,map00561,map01100 - R02689,R04377 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT28 - Glyco_tran_28_C,Glycos_transf_1,MGDG_synth CMS1_k127_2747870_5 1123242.JH636435_gene2385 6.177e-19 91.0 COG0792@1|root,COG0792@2|Bacteria,2J0GX@203682|Planctomycetes 203682|Planctomycetes L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 CMS1_k127_2747870_2 420246.GTNG_1058 7.433e-49 185.0 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,4HB7M@91061|Bacilli,1WF7A@129337|Geobacillus 91061|Bacilli L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII CMS1_k127_2747870_3 1121024.AUCD01000001_gene1666 1.889e-37 144.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,27GF0@186828|Carnobacteriaceae 91061|Bacilli J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 CMS1_k127_27498_0 1379698.RBG1_1C00001G1627 1.504e-245 778.0 COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria 2|Bacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 CMS1_k127_27498_2 404589.Anae109_2337 2.696e-65 237.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria,2YVIZ@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind CMS1_k127_27498_1 880073.Calab_1372 8.641e-74 256.0 COG1624@1|root,COG1624@2|Bacteria,2NPQS@2323|unclassified Bacteria 2|Bacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N,YojJ CMS1_k127_27498_3 926550.CLDAP_16140 3.255e-58 213.0 COG1215@1|root,COG1215@2|Bacteria,2G6E4@200795|Chloroflexi 200795|Chloroflexi M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_trans_2_3,Glycos_transf_2 CMS1_k127_2750512_1 177437.HRM2_48700 3.022e-21 94.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MIMJ@213118|Desulfobacterales 28221|Deltaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_2750512_0 309801.trd_0440 1.782e-140 458.0 COG2006@1|root,COG2006@2|Bacteria,2GA2Y@200795|Chloroflexi,27YWH@189775|Thermomicrobia 189775|Thermomicrobia S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 CMS1_k127_2750512_2 391612.CY0110_12817 3.217e-06 55.0 COG3211@1|root,COG3211@2|Bacteria,1G43U@1117|Cyanobacteria,3KH8Y@43988|Cyanothece 1117|Cyanobacteria Q Bacterial protein of unknown function (DUF839) - - - - - - - - - - - - DUF839 CMS1_k127_2752799_3 880073.Calab_1598 5.451e-21 100.0 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria 2|Bacteria P Prokaryotic cytochrome b561 cbcY - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese CMS1_k127_2752799_2 1123277.KB893206_gene3282 7.526e-41 171.0 COG3386@1|root,COG3386@2|Bacteria,4PKKP@976|Bacteroidetes,47RQ5@768503|Cytophagia 976|Bacteroidetes G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - SGL CMS1_k127_2752799_0 1049564.TevJSym_ax00260 2.112e-50 187.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,1S69P@1236|Gammaproteobacteria 1236|Gammaproteobacteria K crp fnr family - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding CMS1_k127_2752799_1 1448139.AI20_14240 2.104e-47 184.0 COG0457@1|root,COG0457@2|Bacteria,1P0WK@1224|Proteobacteria,1SU5D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 CMS1_k127_2752799_4 1095750.HMPREF9970_2962 4.291e-14 76.0 COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,1HW31@1164882|Lachnoanaerobaculum 186801|Clostridia I BadF/BadG/BcrA/BcrD ATPase family hgdC - - - - - - - - - - - BcrAD_BadFG CMS1_k127_2753152_3 521045.Kole_1492 8.679e-23 113.0 COG0436@1|root,COG0436@2|Bacteria,2GC6H@200918|Thermotogae 200918|Thermotogae E aminotransferase class I and II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_2753152_2 1121344.JHZO01000001_gene447 5.408e-30 138.0 COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia,3WI48@541000|Ruminococcaceae 186801|Clostridia G PFAM M42 glutamyl aminopeptidase celM - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Peptidase_M42 CMS1_k127_2753152_1 867903.ThesuDRAFT_01176 2.656e-78 284.0 COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia 186801|Clostridia G M42 glutamyl aminopeptidase - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Peptidase_M42 CMS1_k127_2753152_0 555088.DealDRAFT_2005 3.306e-86 299.0 COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia 186801|Clostridia G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 CMS1_k127_2753980_0 511062.GU3_11625 1.557e-144 490.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1Y55Q@135624|Aeromonadales 135624|Aeromonadales I Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 CMS1_k127_2753980_1 314282.PCNPT3_06865 4.014e-37 142.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,2QHYZ@267894|Psychromonadaceae 1236|Gammaproteobacteria I Thiolase, C-terminal domain pcaF - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_2756175_2 204669.Acid345_1786 1.715e-109 362.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia 204432|Acidobacteriia C Dehydrogenase E1 component - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C CMS1_k127_2756175_5 1267533.KB906737_gene1567 9.216e-32 136.0 COG2945@1|root,COG2945@2|Bacteria,3Y35I@57723|Acidobacteria,2JIVZ@204432|Acidobacteriia 204432|Acidobacteriia - - - - - ko:K07018 - - - - ko00000 - - - Hydrolase_4 CMS1_k127_2756175_3 649638.Trad_2700 1.762e-70 247.0 COG4221@1|root,COG4221@2|Bacteria,1WIDQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short CMS1_k127_2756175_4 1118054.CAGW01000048_gene1617 1.707e-69 256.0 COG0454@1|root,COG0456@2|Bacteria,1V40T@1239|Firmicutes,4HI2H@91061|Bacilli,26YNM@186822|Paenibacillaceae 91061|Bacilli K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_2756175_6 1121456.ATVA01000012_gene2836 1.305e-22 115.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2WJPP@28221|Deltaproteobacteria,2M8KS@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 CMS1_k127_2756175_1 502025.Hoch_5408 5.378e-127 437.0 COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria,2YTZK@29|Myxococcales 28221|Deltaproteobacteria CE Peptidase family M1 domain pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,HEAT_2,Peptidase_M1 CMS1_k127_2756175_0 234267.Acid_7636 1.873e-169 562.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria 57723|Acidobacteria KLTU Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40,Pkinase CMS1_k127_2757048_0 518766.Rmar_0643 1.693e-152 527.0 COG1196@1|root,COG1196@2|Bacteria,4NHWQ@976|Bacteroidetes,1FIP5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge CMS1_k127_2757048_2 498761.HM1_2174 1.459e-82 301.0 COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N CMS1_k127_2757048_7 338963.Pcar_1225 2.352e-26 124.0 COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1MVRF@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,HDOD CMS1_k127_2757048_5 296591.Bpro_4849 3.867e-58 228.0 COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2WGSI@28216|Betaproteobacteria 28216|Betaproteobacteria K Sigma-54 interaction domain - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - HTH_8,Sigma54_activat CMS1_k127_2757048_6 671143.DAMO_1604 1.409e-51 187.0 COG1143@1|root,COG1143@2|Bacteria,2NPQR@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.5.3 ko:K00337,ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iNJ661.Rv3153 Fer4 CMS1_k127_2757048_4 1379698.RBG1_1C00001G1352 1.159e-60 224.0 COG0428@1|root,COG0428@2|Bacteria,2NQ6J@2323|unclassified Bacteria 2|Bacteria P ZIP Zinc transporter zupT - - ko:K07238,ko:K11021,ko:K16267 - - - - ko00000,ko02000,ko02042 2.A.5.4.11,2.A.5.5 - - Zip CMS1_k127_2757048_3 656024.FsymDg_4006 2.599e-76 262.0 COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4ERM4@85013|Frankiales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 CMS1_k127_2757048_1 867845.KI911784_gene2803 1.592e-131 429.0 COG0649@1|root,COG0649@2|Bacteria,2G5MM@200795|Chloroflexi,3751Y@32061|Chloroflexia 32061|Chloroflexia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD1 - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa CMS1_k127_2757075_6 234267.Acid_5940 2.477e-35 147.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2757075_1 349124.Hhal_1804 1.067e-153 507.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales 135613|Chromatiales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_2757075_7 767434.Fraau_0915 4.829e-33 145.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1X459@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI CMS1_k127_2757075_4 1122925.KB895379_gene2182 5.519e-48 196.0 COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,4HDZQ@91061|Bacilli,26QYK@186822|Paenibacillaceae 91061|Bacilli E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 - - - IGPS CMS1_k127_2757075_2 584708.Apau_1758 5.724e-82 297.0 COG0547@1|root,COG0547@2|Bacteria,3TAEM@508458|Synergistetes 508458|Synergistetes F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 CMS1_k127_2757075_3 574375.BAGA_26305 2.975e-68 255.0 COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,4H9XP@91061|Bacilli,1ZBB7@1386|Bacillus 91061|Bacilli EH Anthranilate synthase pabA GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 ko:K01664 ko00790,map00790 - R01716 RC00010,RC01418 ko00000,ko00001,ko01000 - - iYO844.BSU00750 GATase CMS1_k127_2757075_0 243231.GSU2383 4.627e-155 508.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43TZF@69541|Desulfuromonadales 28221|Deltaproteobacteria H Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657,ko:K13503 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind CMS1_k127_2757075_5 404589.Anae109_0776 1.41e-40 156.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2WJ23@28221|Deltaproteobacteria,2YTSW@29|Myxococcales 28221|Deltaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N CMS1_k127_2760818_6 880073.Calab_1754 1.222e-58 216.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria 2|Bacteria M PKD domain - - 3.2.1.4,3.4.21.66 ko:K01179,ko:K08651 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko01002,ko03110 - GH5,GH9 - Autotransporter,PKD,Peptidase_S8,Peptidase_S8_N,fn3 CMS1_k127_2760818_1 85643.Tmz1t_1473 4.747e-175 575.0 COG0729@1|root,COG1752@1|root,COG0729@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,2KUW0@206389|Rhodocyclales 206389|Rhodocyclales M Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,Patatin CMS1_k127_2760818_8 33876.JNXY01000005_gene8646 2.88e-18 101.0 COG1404@1|root,COG1404@2|Bacteria,2GIRE@201174|Actinobacteria,4DAW0@85008|Micromonosporales 201174|Actinobacteria O Peptidase S8 and S53 subtilisin kexin sedolisin mycP - - ko:K14743 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8 CMS1_k127_2760818_5 935557.ATYB01000009_gene596 1.717e-89 306.0 COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TV61@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Chromate resistance exported protein - - - - - - - - - - - - Chrome_Resist CMS1_k127_2760818_2 886293.Sinac_3963 2.287e-133 443.0 COG2234@1|root,COG2234@2|Bacteria,2IWTP@203682|Planctomycetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_2760818_4 1242864.D187_000932 9.929e-96 334.0 COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria 1224|Proteobacteria G Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 CMS1_k127_2760818_3 234267.Acid_5749 6.252e-128 444.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS1_k127_2760818_0 234267.Acid_7636 1.236e-192 629.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria 57723|Acidobacteria KLTU Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40,Pkinase CMS1_k127_2760818_7 1047013.AQSP01000101_gene615 2.745e-42 173.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Gp58 CMS1_k127_2760818_10 869210.Marky_0572 9.519e-09 65.0 COG0626@1|root,COG0626@2|Bacteria,1WK1T@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E PFAM Cys Met metabolism PLP-dependent enzyme - - 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP CMS1_k127_2761765_2 1267535.KB906767_gene4248 7.28e-26 119.0 COG2318@1|root,COG2318@2|Bacteria,3Y82J@57723|Acidobacteria,2JN4W@204432|Acidobacteriia 204432|Acidobacteriia S Protein of unknown function (DUF664) - - - - - - - - - - - - DinB_2 CMS1_k127_2761765_1 861299.J421_6210 8.127e-54 201.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_6210|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_2761765_0 1297742.A176_05554 1.223e-73 259.0 COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,439QP@68525|delta/epsilon subdivisions,2X537@28221|Deltaproteobacteria,2Z01T@29|Myxococcales 28221|Deltaproteobacteria L Helix-hairpin-helix domain dpbF - - - - - - - - - - - HHH_5,HHH_8 CMS1_k127_2766055_3 667014.Thein_2201 5.116e-115 375.0 COG0499@1|root,COG0499@2|Bacteria,2GGXJ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD CMS1_k127_2766055_1 671143.DAMO_0276 7.836e-168 541.0 COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria 2|Bacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N CMS1_k127_2766055_8 1519464.HY22_02585 6.599e-79 289.0 COG1209@1|root,COG1209@2|Bacteria,1FD8Z@1090|Chlorobi 1090|Chlorobi M Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase CMS1_k127_2766055_10 518766.Rmar_1238 6.586e-53 214.0 COG2222@1|root,COG2222@2|Bacteria,4NIX0@976|Bacteroidetes 976|Bacteroidetes M Bifunctional phosphoglucose phosphomannose isomerase - - 5.3.1.8,5.3.1.9 ko:K15916 ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R01819,R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000 - - - SIS,bact-PGI_C CMS1_k127_2766055_2 273068.TTE2334 5.285e-143 478.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales 186801|Clostridia G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsP - 2.7.3.9,2.7.9.2 ko:K01007,ko:K08483 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C CMS1_k127_2766055_14 1485545.JQLW01000005_gene1240 4.347e-19 100.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria 1224|Proteobacteria G phosphocarrier protein hpr ptsH GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698 - ko:K08485,ko:K11189 ko02060,map02060 - - - ko00000,ko00001,ko02000 4.A.2.1 - - PTS-HPr CMS1_k127_2766055_12 371042.NG99_02250 4.546e-20 105.0 COG3716@1|root,COG3716@2|Bacteria,1MWTZ@1224|Proteobacteria,1RNSD@1236|Gammaproteobacteria,3X7DQ@551|Erwinia 1236|Gammaproteobacteria G PTS system mannose/fructose/sorbose family IID component manZ GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0015144,GO:0015145,GO:0015149,GO:0015578,GO:0015749,GO:0015761,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0022870,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098657,GO:0098704,GO:0098708,GO:0098739,GO:1904659 - ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - iECIAI1_1343.ECIAI1_1888,iECP_1309.ECP_1762,iSBO_1134.SBO_1231,iSF_1195.SF1409,iSFxv_1172.SFxv_1596,iS_1188.S1524 EIID-AGA CMS1_k127_2766055_13 1304872.JAGC01000004_gene2188 2.718e-19 98.0 COG3444@1|root,COG3444@2|Bacteria,1R4ES@1224|Proteobacteria,42VCG@68525|delta/epsilon subdivisions,2WRN8@28221|Deltaproteobacteria,2MBGK@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM PTS system sorbose subfamily IIB component - - 2.7.1.191 ko:K02794 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 - - PTSIIB_sorb CMS1_k127_2766055_16 1379698.RBG1_1C00001G0554 8.083e-11 67.0 COG2893@1|root,COG2893@2|Bacteria,2NRZU@2323|unclassified Bacteria 2|Bacteria G system, fructose subfamily IIA component - - 2.7.1.191 ko:K02793,ko:K02794 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 - - EIIA-man CMS1_k127_2766055_5 1379698.RBG1_1C00001G0553 1.414e-100 342.0 COG1493@1|root,COG1493@2|Bacteria,2NP5B@2323|unclassified Bacteria 2|Bacteria T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N CMS1_k127_2766055_15 1125863.JAFN01000001_gene902 3.975e-17 89.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,42SJW@68525|delta/epsilon subdivisions,2WPF7@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE CMS1_k127_2766055_4 1125863.JAFN01000001_gene903 2.4e-107 366.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD CMS1_k127_2766055_7 373903.Hore_17500 2.574e-87 304.0 COG1137@1|root,COG1137@2|Bacteria,1UJSV@1239|Firmicutes,25F98@186801|Clostridia,3WAB6@53433|Halanaerobiales 186801|Clostridia S PFAM ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran CMS1_k127_2766055_11 1379698.RBG1_1C00001G0548 2.317e-22 105.0 COG3117@1|root,COG3117@2|Bacteria,2NQ8Q@2323|unclassified Bacteria 2|Bacteria S Lipopolysaccharide-assembly, LptC-related lptC - - ko:K09774,ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC CMS1_k127_2766055_6 1211114.ALIP01000025_gene139 1.305e-89 306.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1X3K3@135614|Xanthomonadales 135614|Xanthomonadales M Arabinose 5-phosphate isomerase kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS CMS1_k127_2766055_9 765910.MARPU_02635 3.055e-77 275.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 CMS1_k127_2766055_0 1094508.Tsac_0366 8.571e-220 695.0 COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42F21@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS01075 CTP_synth_N,GATase CMS1_k127_2766714_0 1192034.CAP_5767 3.301e-36 144.0 COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,42VYV@68525|delta/epsilon subdivisions,2WRGQ@28221|Deltaproteobacteria,2Z0X7@29|Myxococcales 28221|Deltaproteobacteria K MerR, DNA binding - - - ko:K19591 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 CMS1_k127_2766714_2 1123248.KB893381_gene1007 0.000752 48.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cupredoxin_1 CMS1_k127_2766714_1 485913.Krac_8476 1.058e-11 76.0 COG3794@1|root,COG3794@2|Bacteria,2G7GX@200795|Chloroflexi 200795|Chloroflexi C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 CMS1_k127_2779895_5 316274.Haur_3256 1.205e-22 106.0 2DQAK@1|root,335NK@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4919) - - - - - - - - - - - - DUF4919 CMS1_k127_2779895_4 926550.CLDAP_13010 5.396e-32 136.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,TPR_12,Trans_reg_C CMS1_k127_2779895_2 523791.Kkor_1780 9.874e-70 255.0 COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,1PM1H@1224|Proteobacteria,1RUN8@1236|Gammaproteobacteria,1XQN3@135619|Oceanospirillales 135619|Oceanospirillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS1_k127_2779895_0 523791.Kkor_1781 1.57e-76 270.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XHSS@135619|Oceanospirillales 135619|Oceanospirillales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_2779895_3 309807.SRU_1789 2.058e-39 156.0 2CDT7@1|root,2ZZ6E@2|Bacteria,4PERQ@976|Bacteroidetes,1FJHB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_2779895_1 1519464.HY22_13125 2.463e-71 256.0 COG0737@1|root,COG1520@1|root,COG0737@2|Bacteria,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - 3.4.17.18 ko:K05996 - - - - ko00000,ko01000,ko01002 - - - 5_nucleotid_C,Cytochrome_C554,SBP_bac_8,SLH CMS1_k127_2784464_6 237368.SCABRO_03960 3.644e-23 100.0 COG0705@1|root,COG0705@2|Bacteria,2IZZY@203682|Planctomycetes 203682|Planctomycetes S PFAM Rhomboid family - - - - - - - - - - - - Rhomboid CMS1_k127_2784464_7 1382356.JQMP01000004_gene244 1.413e-18 90.0 COG2332@1|root,COG2332@2|Bacteria,2G7CS@200795|Chloroflexi,27YD4@189775|Thermomicrobia 189775|Thermomicrobia O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH - - - ko:K02197 - - - - ko00000 - - - CcmE CMS1_k127_2784464_0 671143.DAMO_1588 1.099e-173 567.0 COG1138@1|root,COG1138@2|Bacteria,2NNYV@2323|unclassified Bacteria 2|Bacteria O Cytochrome C assembly protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198,ko:K04016 - - R05712 RC00176 ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm CMS1_k127_2784464_10 635013.TherJR_2281 5.868e-09 70.0 COG3088@1|root,COG3088@2|Bacteria,1VETA@1239|Firmicutes,24TPT@186801|Clostridia,265EA@186807|Peptococcaceae 186801|Clostridia P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH CMS1_k127_2784464_8 485913.Krac_8611 2.533e-14 87.0 COG2010@1|root,COG2010@2|Bacteria,2G741@200795|Chloroflexi 200795|Chloroflexi C Cytochrome c - - - - - - - - - - - - CarboxypepD_reg,Cytochrome_CBB3 CMS1_k127_2784464_4 1347086.CCBA010000026_gene3184 1.862e-43 167.0 COG1131@1|root,COG1131@2|Bacteria,1V7J1@1239|Firmicutes,4HJPG@91061|Bacilli,1ZPZ7@1386|Bacillus 91061|Bacilli V COG1131 ABC-type multidrug transport system, ATPase component - - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran CMS1_k127_2784464_9 1121456.ATVA01000015_gene2386 1.296e-13 83.0 COG2386@1|root,COG2386@2|Bacteria,1QF23@1224|Proteobacteria,42RAM@68525|delta/epsilon subdivisions,2WMS1@28221|Deltaproteobacteria,2M9DD@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM Cytochrome c-type biogenesis protein CcmB ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB CMS1_k127_2784464_3 635013.TherJR_2276 1.227e-43 177.0 COG0755@1|root,COG0755@2|Bacteria,1V4A6@1239|Firmicutes,24IWH@186801|Clostridia,264K0@186807|Peptococcaceae 186801|Clostridia O Cytochrome c assembly protein - - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm CMS1_k127_2784464_5 1156937.MFUM_880007 1.594e-24 108.0 COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,46SGF@74201|Verrucomicrobia,37G6C@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia HP ThiF family thiF - 2.7.7.80,2.8.1.11 ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF CMS1_k127_2784464_1 62928.azo1880 4.405e-57 216.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,2VHMT@28216|Betaproteobacteria,2KVPY@206389|Rhodocyclales 206389|Rhodocyclales S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 CMS1_k127_2784464_2 1131269.AQVV01000009_gene1116 1.003e-53 202.0 COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria 2|Bacteria M lipoprotein localization to outer membrane lolE-2 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_2785604_1 443143.GM18_1106 3.132e-11 74.0 COG2373@1|root,COG2931@1|root,COG4932@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - - - - - - - - - - A2M,An_peroxidase,CHRD,CarboxypepD_reg CMS1_k127_2785604_2 880073.Calab_3215 9.674e-07 60.0 COG0366@1|root,COG0708@1|root,COG0366@2|Bacteria,COG0708@2|Bacteria,2NREA@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolase family 70 - - 3.1.11.2,3.2.1.1 ko:K01142,ko:K01176 ko00500,ko01100,ko03410,ko04973,map00500,map01100,map03410,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000,ko03400 - GH13 - Alpha-amylase,CBM_25,DUF1939,He_PIG CMS1_k127_2785604_0 945713.IALB_2334 9.428e-19 94.0 COG0737@1|root,COG0737@2|Bacteria 2|Bacteria F nucleotide catabolic process - - 3.1.3.6,3.1.4.16 ko:K01119 ko00230,ko00240,map00230,map00240 - R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135 RC00078,RC00296 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,F5_F8_type_C,Metallophos,SLH CMS1_k127_2788074_5 1120985.AUMI01000020_gene1269 0.0002839 44.0 COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,4H30W@909932|Negativicutes 909932|Negativicutes J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b CMS1_k127_2788074_4 443144.GM21_1926 1.255e-43 172.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,42RG5@68525|delta/epsilon subdivisions,2WNRE@28221|Deltaproteobacteria,43SVJ@69541|Desulfuromonadales 28221|Deltaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA CMS1_k127_2788074_3 671143.DAMO_1200 8.943e-44 167.0 COG1386@1|root,COG1386@2|Bacteria,2NPPM@2323|unclassified Bacteria 2|Bacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB CMS1_k127_2788074_2 429009.Adeg_1292 8.574e-48 181.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42G4B@68295|Thermoanaerobacterales 186801|Clostridia J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 CMS1_k127_2788074_0 933262.AXAM01000023_gene663 9.8e-100 340.0 COG0079@1|root,COG0283@1|root,COG0079@2|Bacteria,COG0283@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,2MIX3@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_2788074_1 767817.Desgi_2545 3.843e-51 200.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,2603K@186807|Peptococcaceae 186801|Clostridia E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase CMS1_k127_2792973_7 398767.Glov_2398 2.533e-45 182.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42R04@68525|delta/epsilon subdivisions,2WMZ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM ATPase, BadF BadG BcrA BcrD type - - - - - - - - - - - - BcrAD_BadFG CMS1_k127_2792973_3 398767.Glov_2399 6.633e-88 316.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales 28221|Deltaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family yjiL - - - - - - - - - - - BcrAD_BadFG CMS1_k127_2792973_1 398767.Glov_2400 1.005e-119 399.0 COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,430HE@68525|delta/epsilon subdivisions,2WVZI@28221|Deltaproteobacteria,43V4N@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D CMS1_k127_2792973_2 398767.Glov_2401 9.799e-112 374.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D CMS1_k127_2792973_5 76114.ebA5296 2.919e-49 185.0 COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,2VUI3@28216|Betaproteobacteria,2KWVM@206389|Rhodocyclales 206389|Rhodocyclales I Enoyl-CoA hydratase/isomerase dch - 4.2.1.100 ko:K07537 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05597 RC03168 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_2792973_4 316067.Geob_0099 8.642e-63 226.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_2792973_0 1187851.A33M_3194 6.156e-150 482.0 COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.21 ko:K07539 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05593,R05594,R10696 RC01430,RC01431,RC03237 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_2792973_6 1232410.KI421412_gene166 4.495e-46 170.0 COG1064@1|root,COG1064@2|Bacteria,1QVIH@1224|Proteobacteria,42NMX@68525|delta/epsilon subdivisions,2WJGB@28221|Deltaproteobacteria,43TA2@69541|Desulfuromonadales 28221|Deltaproteobacteria C Alanine dehydrogenase/PNT, C-terminal domain bamQ - 1.1.1.368 ko:K07538 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05581 RC00850 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_2803769_1 404589.Anae109_2247 9.22e-54 203.0 COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,42RB0@68525|delta/epsilon subdivisions,2WN8G@28221|Deltaproteobacteria,2Z0N6@29|Myxococcales 28221|Deltaproteobacteria S Pfam Transposase IS66 - - - - - - - - - - - - - CMS1_k127_2803769_0 1379698.RBG1_1C00001G1834 1.258e-82 283.0 COG1028@1|root,COG1028@2|Bacteria,2NQVI@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.3.1.104 ko:K10780 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_2803769_3 309801.trd_0409 1.374e-36 147.0 COG1999@1|root,COG1999@2|Bacteria,2G6UW@200795|Chloroflexi,27Z5W@189775|Thermomicrobia 189775|Thermomicrobia S SCO1/SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC CMS1_k127_2803769_2 68223.JNZY01000002_gene4869 6.923e-38 144.0 COG0662@1|root,COG0662@2|Bacteria,2IHU8@201174|Actinobacteria 201174|Actinobacteria G PFAM Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 CMS1_k127_2804577_4 880073.Calab_2425 1.087e-13 77.0 COG0848@1|root,COG0848@2|Bacteria 2|Bacteria U biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD CMS1_k127_2804577_0 880073.Calab_2424 2.425e-50 188.0 COG0811@1|root,COG0811@2|Bacteria,2NPUZ@2323|unclassified Bacteria 2|Bacteria U MotA/TolQ/ExbB proton channel family exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB CMS1_k127_2804577_3 1379698.RBG1_1C00001G1358 9.147e-14 81.0 COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria 2|Bacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C CMS1_k127_2804577_2 1379698.RBG1_1C00001G1358 1.236e-27 126.0 COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria 2|Bacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C CMS1_k127_2804577_1 517418.Ctha_2330 2.066e-33 135.0 COG0848@1|root,COG0848@2|Bacteria,1FE26@1090|Chlorobi 1090|Chlorobi U PFAM Biopolymer transport protein ExbD TolR - - - - - - - - - - - - ExbD CMS1_k127_2809454_1 1144275.COCOR_03643 1.017e-59 222.0 COG3401@1|root,COG5492@1|root,COG3401@2|Bacteria,COG5492@2|Bacteria,1N06B@1224|Proteobacteria 1224|Proteobacteria N FG-GAP repeat protein - - - - - - - - - - - - - CMS1_k127_2809454_5 246197.MXAN_5837 1.863e-10 72.0 COG4932@1|root,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,438GF@68525|delta/epsilon subdivisions,2X3RA@28221|Deltaproteobacteria,2YWWZ@29|Myxococcales 28221|Deltaproteobacteria M Bacterial Ig-like domain (group 1) - - - - - - - - - - - - Big_1,LTD CMS1_k127_2809454_3 1089550.ATTH01000001_gene1005 1.103e-25 121.0 COG1404@1|root,COG3591@1|root,COG4932@1|root,COG1404@2|Bacteria,COG3591@2|Bacteria,COG4932@2|Bacteria,4NG2K@976|Bacteroidetes,1FJTD@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EO Trypsin-like serine protease - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - P_proprotein,Trypsin_2 CMS1_k127_2809454_4 1033743.CAES01000085_gene2958 1.561e-12 79.0 COG1404@1|root,COG2730@1|root,COG1404@2|Bacteria,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process celA7 - 3.2.1.4,3.2.1.78 ko:K01179,ko:K01218 ko00051,ko00500,ko01100,ko02024,map00051,map00500,map01100,map02024 - R01332,R06200,R11307,R11308 RC00467 ko00000,ko00001,ko01000 - GH26,GH5,GH9 - CBM_3,CBM_35,F5_F8_type_C,Glyco_hydro_26,Glyco_hydro_44,Peptidase_S8,SLH,fn3 CMS1_k127_2809454_0 667014.Thein_0701 4.471e-67 241.0 COG0726@1|root,COG0726@2|Bacteria,2GIER@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Domain of unknown function (DUF3473) - - - - - - - - - - - - DUF3473,Polysacc_deac_1 CMS1_k127_2814320_1 1144275.COCOR_01346 2.067e-22 100.0 COG0848@1|root,COG0848@2|Bacteria,1Q1RQ@1224|Proteobacteria,437EZ@68525|delta/epsilon subdivisions,2X2MA@28221|Deltaproteobacteria,2Z03D@29|Myxococcales 28221|Deltaproteobacteria U Biopolymer transport protein - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD CMS1_k127_2814320_0 502025.Hoch_0369 5.31e-41 173.0 COG2340@1|root,COG2340@2|Bacteria,1REVB@1224|Proteobacteria,4386P@68525|delta/epsilon subdivisions,2X3GI@28221|Deltaproteobacteria,2YW01@29|Myxococcales 28221|Deltaproteobacteria S Cysteine-rich secretory protein family - - - - - - - - - - - - CAP CMS1_k127_2827909_3 865937.Gilli_2027 1.003e-48 181.0 COG2908@1|root,COG2908@2|Bacteria,4NEF1@976|Bacteroidetes,1HWZZ@117743|Flavobacteriia,2P64N@244698|Gillisia 976|Bacteroidetes S Calcineurin-like phosphoesterase lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 CMS1_k127_2827909_0 269799.Gmet_1014 4.512e-109 370.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP-2 - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS1_k127_2827909_2 1121935.AQXX01000114_gene3272 1.719e-71 257.0 COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1XHQX@135619|Oceanospirillales 135619|Oceanospirillales M N-acetylmuramoyl-L-alanine amidase amiB - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM CMS1_k127_2827909_8 572547.Amico_1896 5.511e-05 53.0 COG2217@1|root,COG2217@2|Bacteria,3T9XP@508458|Synergistetes 508458|Synergistetes P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase CMS1_k127_2827909_1 1137268.AZXF01000023_gene1279 1.183e-72 274.0 COG1472@1|root,COG1472@2|Bacteria,2GM43@201174|Actinobacteria,4EFGK@85012|Streptosporangiales 201174|Actinobacteria G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C CMS1_k127_2827909_4 1218352.B597_021245 1.967e-40 170.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1Z0T3@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022613,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0036094,GO:0042254,GO:0042274,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - iAF1260.b4161,iBWG_1329.BWG_3876,iECDH10B_1368.ECDH10B_4356,iECDH1ME8569_1439.ECDH1ME8569_4021,iEKO11_1354.EKO11_4148,iEcDH1_1363.EcDH1_3829,iEcolC_1368.EcolC_3849,iJO1366.b4161,iUMNK88_1353.UMNK88_5099,iY75_1357.Y75_RS21675 RsgA_GTPase CMS1_k127_2827909_7 1123274.KB899407_gene173 7.656e-07 60.0 COG0457@1|root,COG0457@2|Bacteria 1123274.KB899407_gene173|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_2827909_6 243231.GSU0485 3.976e-34 151.0 COG3222@1|root,COG3222@2|Bacteria,1RHCP@1224|Proteobacteria,43B9I@68525|delta/epsilon subdivisions,2X6NN@28221|Deltaproteobacteria,43SK2@69541|Desulfuromonadales 28221|Deltaproteobacteria S Guanylyl transferase CofC like - - - ko:K09931 - - - - ko00000 - - - DUF2064 CMS1_k127_2827909_5 760011.Spico_0856 6.858e-39 159.0 COG0122@1|root,COG0122@2|Bacteria 2|Bacteria L 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase alkA - 4.2.99.18 ko:K03660 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD,OGG_N CMS1_k127_2829225_3 391625.PPSIR1_32884 5.689e-33 129.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate CMS1_k127_2829225_2 1191523.MROS_0285 1.668e-56 220.0 2E09V@1|root,32VXB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_2829225_0 530564.Psta_3550 1.69e-98 352.0 COG0248@1|root,COG0248@2|Bacteria,2IYSV@203682|Planctomycetes 203682|Planctomycetes FP Ppx GppA phosphatase - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA CMS1_k127_2829225_1 1192034.CAP_4095 1.271e-60 219.0 COG0248@1|root,COG2206@1|root,COG0248@2|Bacteria,COG2206@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria,2YUZ0@29|Myxococcales 28221|Deltaproteobacteria FP Ppx/GppA phosphatase family gppA-2 - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA CMS1_k127_2831462_4 66692.ABC2592 3.719e-13 74.0 COG2318@1|root,COG2318@2|Bacteria,1V5WQ@1239|Firmicutes,4HHAG@91061|Bacilli,1ZQUZ@1386|Bacillus 91061|Bacilli S DinB family - - - - - - - - - - - - DinB CMS1_k127_2831462_1 518766.Rmar_2008 6.002e-190 604.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FJ1P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 ko:K00128,ko:K00135 ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00027,M00135 R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS1_k127_2831462_0 649638.Trad_0897 0.0 1086.0 COG0567@1|root,COG0567@2|Bacteria,1WIKA@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C dehydrogenase e1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr CMS1_k127_2831462_3 502025.Hoch_4995 3.538e-142 467.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,42N18@68525|delta/epsilon subdivisions,2WJSK@28221|Deltaproteobacteria,2Z2W5@29|Myxococcales 28221|Deltaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.12,2.3.1.61 ko:K00627,ko:K00658 ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00307 R00209,R02569,R02570,R02571,R08549 RC00004,RC02727,RC02742,RC02833,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2766 2-oxoacid_dh,Biotin_lipoyl,E3_binding CMS1_k127_2831462_2 1123242.JH636434_gene4049 6.992e-189 600.0 COG1249@1|root,COG1249@2|Bacteria,2IX5H@203682|Planctomycetes 203682|Planctomycetes C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim CMS1_k127_2834149_5 448385.sce6976 1.198e-44 183.0 COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria 2|Bacteria C ATP:ADP antiporter activity - - - ko:K01932,ko:K03301 - - - - ko00000,ko01000 2.A.12 - - Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC CMS1_k127_2834149_3 103733.JNYO01000009_gene4711 1.47e-61 231.0 COG1073@1|root,COG1073@2|Bacteria,2GMK3@201174|Actinobacteria,4E10C@85010|Pseudonocardiales 201174|Actinobacteria S Prolyl oligopeptidase family - - - ko:K06889 - - - - ko00000 - - - Abhydrolase_1,Abhydrolase_4,Hydrolase_4,Peptidase_S9 CMS1_k127_2834149_9 543728.Vapar_6380 8.054e-28 120.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VR5K@28216|Betaproteobacteria,4ABQH@80864|Comamonadaceae 28216|Betaproteobacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2834149_13 240015.ACP_2637 5.935e-11 70.0 COG0764@1|root,COG0764@2|Bacteria,3Y7I3@57723|Acidobacteria,2JP4P@204432|Acidobacteriia 204432|Acidobacteriia I FabA-like domain - - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA CMS1_k127_2834149_1 644966.Tmar_0951 4.569e-109 369.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WCS5@538999|Clostridiales incertae sedis 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt CMS1_k127_2834149_6 1463934.JOCF01000067_gene5210 1.788e-43 173.0 COG1028@1|root,COG1028@2|Bacteria,2GMWG@201174|Actinobacteria 201174|Actinobacteria IQ reductase phbB - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_2834149_12 530564.Psta_1588 1.41e-12 72.0 COG0236@1|root,COG0236@2|Bacteria,2J04I@203682|Planctomycetes 203682|Planctomycetes IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - - - - - - - - - - PP-binding CMS1_k127_2834149_8 67373.JOBF01000013_gene4116 4.292e-31 131.0 COG0623@1|root,COG0623@2|Bacteria,2I3B8@201174|Actinobacteria 201174|Actinobacteria I Enoyl-(Acyl carrier protein) reductase - - 1.3.1.104 ko:K10780 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_2834149_7 927658.AJUM01000034_gene567 4.187e-36 156.0 29X8I@1|root,30IXV@2|Bacteria,4P0MB@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_2834149_11 219305.MCAG_03530 5.07e-15 84.0 COG2977@1|root,COG2977@2|Bacteria,2IIA2@201174|Actinobacteria,4DANP@85008|Micromonosporales 201174|Actinobacteria Q Belongs to the P-Pant transferase superfamily - - - - - - - - - - - - ACPS CMS1_k127_2834149_2 309799.DICTH_0614 1.264e-70 258.0 COG0253@1|root,COG0253@2|Bacteria 2|Bacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase CMS1_k127_2834149_10 379066.GAU_1903 2.595e-19 100.0 COG0599@1|root,COG0599@2|Bacteria,1ZTPF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD CMS1_k127_2834149_0 1128421.JAGA01000002_gene62 2.058e-118 389.0 COG0627@1|root,COG0627@2|Bacteria,2NQQ3@2323|unclassified Bacteria 2|Bacteria S Putative esterase - - - - - - - - - - - - Esterase CMS1_k127_2834149_4 1303518.CCALI_01697 3.165e-60 217.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 CMS1_k127_2839223_0 330214.NIDE1634 1.017e-201 645.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3J101@40117|Nitrospirae 40117|Nitrospirae G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N CMS1_k127_2840810_2 1123276.KB893262_gene4037 1.987e-18 95.0 COG1090@1|root,COG1090@2|Bacteria 2|Bacteria S coenzyme binding - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase,Lipocalin_2,NAD_binding_10 CMS1_k127_2840810_1 861299.J421_0535 1.321e-61 232.0 COG1228@1|root,COG1228@2|Bacteria,1ZSU7@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS1_k127_2840810_0 1278073.MYSTI_05720 5.858e-73 273.0 COG2234@1|root,COG2234@2|Bacteria,1MUZ7@1224|Proteobacteria 1224|Proteobacteria S Peptidase m28 - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_2843093_1 926550.CLDAP_29770 2.624e-75 284.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - DUF3883,Helicase_C,SNF2_N CMS1_k127_2843093_0 234267.Acid_2834 1.077e-126 432.0 COG1236@1|root,COG1236@2|Bacteria,3Y6U0@57723|Acidobacteria 57723|Acidobacteria J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL CMS1_k127_2843093_2 1120973.AQXL01000121_gene41 1.763e-69 257.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,277XE@186823|Alicyclobacillaceae 91061|Bacilli D Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase CMS1_k127_2843093_3 880072.Desac_1609 4.287e-28 120.0 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2WRG0@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N CMS1_k127_2843093_4 1713.JOFV01000015_gene1767 3.344e-19 89.0 COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4F0R5@85016|Cellulomonadaceae 201174|Actinobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N CMS1_k127_2849942_0 1123354.AUDR01000016_gene1333 5.712e-142 474.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,1KRET@119069|Hydrogenophilales 119069|Hydrogenophilales L RecG wedge domain - - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge CMS1_k127_2849942_3 861299.J421_3210 1.206e-20 101.0 2F3JX@1|root,33WDB@2|Bacteria,1ZTZI@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - zinc_ribbon_4 CMS1_k127_2849942_2 298655.KI912266_gene6175 1.76e-24 119.0 COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,4ERRT@85013|Frankiales 201174|Actinobacteria EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_3 CMS1_k127_2849942_1 290397.Adeh_2418 1.442e-70 255.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,42PT6@68525|delta/epsilon subdivisions,2WK6I@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.345 ko:K08256 - - R11702 - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_2849942_4 351607.Acel_1354 1.79e-20 103.0 COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4ESDA@85013|Frankiales 201174|Actinobacteria M lipid A biosynthesis acyltransferase htrB GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 ko:K22311 - - - - ko00000,ko01000 - - - Lip_A_acyltrans CMS1_k127_2850361_1 448385.sce0363 7.605e-113 384.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS1_k127_2850361_2 1396418.BATQ01000049_gene425 9.445e-33 134.0 COG2606@1|root,COG2606@2|Bacteria,46VWQ@74201|Verrucomicrobia,2IUV0@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Aminoacyl-tRNA editing domain - - - - - - - - - - - - tRNA_edit CMS1_k127_2850361_0 204669.Acid345_2395 1.337e-157 512.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K08282,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16,TPR_2,TPR_8 CMS1_k127_2853895_1 1335757.SPICUR_05770 1.002e-84 295.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_2853895_3 1499967.BAYZ01000095_gene4149 1.92e-32 135.0 COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria 2|Bacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS1_k127_2853895_0 880073.Calab_2438 1.32e-290 905.0 COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria 2|Bacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 CMS1_k127_2853895_2 204669.Acid345_2013 1.383e-65 248.0 COG0225@1|root,COG0225@2|Bacteria,3Y4DM@57723|Acidobacteria,2JJ10@204432|Acidobacteriia 204432|Acidobacteriia O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR CMS1_k127_2855162_1 1379698.RBG1_1C00001G0119 3.778e-16 85.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - CMS1_k127_2855162_2 1121924.ATWH01000006_gene1962 2.242e-10 74.0 COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria,4FMGJ@85023|Microbacteriaceae 201174|Actinobacteria Q Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 CMS1_k127_2855162_0 525897.Dbac_2942 6.509e-99 335.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_2855976_0 1267535.KB906767_gene2605 0.0 1149.0 COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia 204432|Acidobacteriia C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase CMS1_k127_2855976_2 1403819.BATR01000057_gene1781 4.163e-33 137.0 COG5522@1|root,COG5522@2|Bacteria,46WTQ@74201|Verrucomicrobia,2IW7Y@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Integral membrane protein (intg_mem_TP0381) - - - - - - - - - - - - Intg_mem_TP0381 CMS1_k127_2855976_1 234267.Acid_3938 9.537e-67 243.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS1_k127_2886283_6 1379698.RBG1_1C00001G0115 2.765e-87 302.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - CMS1_k127_2886283_4 1379698.RBG1_1C00001G0120 2.217e-111 397.0 28II6@1|root,2Z8JB@2|Bacteria,2NNT1@2323|unclassified Bacteria 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - CMS1_k127_2886283_1 1379698.RBG1_1C00001G0122 2.659e-265 829.0 COG1070@1|root,COG1070@2|Bacteria,2NP2A@2323|unclassified Bacteria 2|Bacteria G MutL protein - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N,MutL CMS1_k127_2886283_8 1379698.RBG1_1C00001G0125 6.546e-20 95.0 2EGJW@1|root,3110Q@2|Bacteria,2NS2A@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_2886283_9 1379698.RBG1_1C00001G0126 2.085e-06 57.0 2C451@1|root,2ZRAU@2|Bacteria,2NS2X@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_2886283_2 1118054.CAGW01000078_gene3187 4.364e-163 548.0 COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,4HB80@91061|Bacilli,26RUP@186822|Paenibacillaceae 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P CMS1_k127_2886283_3 1121423.JONT01000001_gene2099 4.761e-120 420.0 COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,2608E@186807|Peptococcaceae 186801|Clostridia E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P CMS1_k127_2886283_7 1382315.JPOI01000001_gene1276 3.016e-39 164.0 COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,1WGDI@129337|Geobacillus 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H CMS1_k127_2886283_5 660470.Theba_2214 8.664e-102 343.0 COG0404@1|root,COG0404@2|Bacteria,2GC8B@200918|Thermotogae 200918|Thermotogae E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - DUF2007,GCV_T,GCV_T_C CMS1_k127_2886283_0 1121472.AQWN01000005_gene2354 0.0 1158.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,260NC@186807|Peptococcaceae 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran CMS1_k127_2890995_0 926569.ANT_06940 2.777e-61 221.0 COG0842@1|root,COG0842@2|Bacteria,2G8MV@200795|Chloroflexi 200795|Chloroflexi V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane CMS1_k127_2890995_2 269799.Gmet_0728 7.354e-15 83.0 COG0457@1|root,COG0457@2|Bacteria,1P22J@1224|Proteobacteria,4310H@68525|delta/epsilon subdivisions,2WWBW@28221|Deltaproteobacteria,43VHQ@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_2890995_1 650150.ERH_0005 9.851e-19 94.0 COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1TPKU@1239|Firmicutes,3VPJU@526524|Erysipelotrichia 526524|Erysipelotrichia GT COG COG1299 Phosphotransferase system, fructose-specific IIC component - - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB CMS1_k127_2890995_3 1238237.CP10139811_0982 7.097e-06 54.0 COG1579@1|root,COG1579@2|Bacteria,2JFRJ@204428|Chlamydiae 204428|Chlamydiae S C4-type zinc ribbon domain CP_0228 - - ko:K07164 - - - - ko00000 - - - zf-RING_7 CMS1_k127_2893324_1 314278.NB231_00974 1.514e-05 58.0 COG3147@1|root,COG3147@2|Bacteria,1MXHQ@1224|Proteobacteria,1RRKM@1236|Gammaproteobacteria,1WZKK@135613|Chromatiales 135613|Chromatiales D Sporulation related domain - - - ko:K03749 - - - - ko00000 - - - SPOR CMS1_k127_2893324_0 1298593.TOL_2282 1.468e-14 86.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1XHIB@135619|Oceanospirillales 135619|Oceanospirillales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_19,TPR_7 CMS1_k127_2898209_2 273068.TTE2394 3.96e-51 186.0 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,42G9G@68295|Thermoanaerobacterales 186801|Clostridia F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran CMS1_k127_2898209_0 880073.Calab_0823 2.511e-72 254.0 COG0572@1|root,COG0572@2|Bacteria,2NPKT@2323|unclassified Bacteria 2|Bacteria F Phosphoribulokinase / Uridine kinase family udk GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19,2.7.1.48 ko:K00855,ko:K00876 ko00240,ko00710,ko00983,ko01100,ko01120,ko01200,map00240,map00710,map00983,map01100,map01120,map01200 M00165,M00166 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01523,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_0893 PRK CMS1_k127_2898209_5 889378.Spiaf_1190 8.85e-09 67.0 COG1079@1|root,COG1079@2|Bacteria,2J646@203691|Spirochaetes 203691|Spirochaetes S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 CMS1_k127_2898209_3 518766.Rmar_0664 2.033e-43 179.0 COG0005@1|root,COG0005@2|Bacteria,4NE4J@976|Bacteroidetes,1FINK@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate xapA - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 CMS1_k127_2898209_1 483219.LILAB_31320 1.69e-55 220.0 COG0652@1|root,COG1413@1|root,COG0652@2|Bacteria,COG1413@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2WWSG@28221|Deltaproteobacteria,2YVBS@29|Myxococcales 28221|Deltaproteobacteria M Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - HEAT_2,Pro_isomerase CMS1_k127_2898209_4 1382306.JNIM01000001_gene4183 4.969e-16 83.0 COG0859@1|root,COG0859@2|Bacteria 2|Bacteria M ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - - - - - - - - - - Glyco_transf_9 CMS1_k127_2899268_1 926549.KI421517_gene2980 7.795e-138 456.0 COG2120@1|root,COG2120@2|Bacteria,4NE9K@976|Bacteroidetes,47KXK@768503|Cytophagia 976|Bacteroidetes G PFAM GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L CMS1_k127_2899268_0 1047013.AQSP01000125_gene2632 4.029e-193 623.0 COG0591@1|root,COG0591@2|Bacteria,2NR0M@2323|unclassified Bacteria 2|Bacteria E Sodium:solute symporter family yidK - - - - - - - - - - - SSF CMS1_k127_2899268_2 215803.DB30_4215 1.732e-51 197.0 COG0457@1|root,COG0457@2|Bacteria,1Q3NI@1224|Proteobacteria,43422@68525|delta/epsilon subdivisions,2X4RF@28221|Deltaproteobacteria,2YZFW@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF2911) - - - - - - - - - - - - DUF2911 CMS1_k127_2905802_1 493475.GARC_2783 8.598e-119 389.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,468D5@72275|Alteromonadaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_2905802_0 493475.GARC_2784 1.007e-137 463.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,468D5@72275|Alteromonadaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_2905802_2 1089550.ATTH01000001_gene2244 8.592e-92 311.0 COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,1FIVB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_2912992_1 1232428.CAVO010000051_gene2214 5.274e-74 261.0 COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,4H1XA@909932|Negativicutes 909932|Negativicutes H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC CMS1_k127_2912992_0 1125863.JAFN01000001_gene1123 7.638e-86 306.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH CMS1_k127_2912992_2 1397528.Q671_05750 1.135e-10 68.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1XI5V@135619|Oceanospirillales 135619|Oceanospirillales S cytochrome C - - - - - - - - - - - - Cytochrom_C_asm CMS1_k127_2917711_3 379066.GAU_2370 3.814e-46 171.0 COG0704@1|root,COG0704@2|Bacteria 2|Bacteria P negative regulation of phosphate transmembrane transport phoU GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU CMS1_k127_2917711_4 1123371.ATXH01000041_gene683 3.499e-21 105.0 COG2220@1|root,COG2220@2|Bacteria,2GIDZ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 CMS1_k127_2917711_5 269799.Gmet_0085 6.232e-21 104.0 COG2365@1|root,COG2365@2|Bacteria,1N0NB@1224|Proteobacteria,43CF8@68525|delta/epsilon subdivisions,2X60D@28221|Deltaproteobacteria,43UY8@69541|Desulfuromonadales 28221|Deltaproteobacteria T Dual specificity phosphatase, catalytic domain - - - - - - - - - - - - Y_phosphatase2 CMS1_k127_2917711_1 1191523.MROS_2638 2.995e-87 311.0 COG0581@1|root,COG0581@2|Bacteria 2|Bacteria P inorganic phosphate transmembrane transporter activity pstA GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - ko:K02037,ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 CMS1_k127_2917711_2 204669.Acid345_2974 5.315e-85 293.0 COG0573@1|root,COG0573@2|Bacteria,3Y42Y@57723|Acidobacteria,2JIJN@204432|Acidobacteriia 204432|Acidobacteriia P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 CMS1_k127_2917711_0 644966.Tmar_1649 1.827e-112 376.0 COG0226@1|root,COG0226@2|Bacteria,1UFGH@1239|Firmicutes,24D85@186801|Clostridia,3WDS1@538999|Clostridiales incertae sedis 186801|Clostridia P TIGRFAM phosphate ABC transporter, phosphate-binding protein - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 CMS1_k127_2924638_0 234267.Acid_7851 1.402e-119 407.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria 57723|Acidobacteria K Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_2924638_1 234267.Acid_7637 2.281e-32 145.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_2927712_1 448385.sce0363 8.1e-119 402.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS1_k127_2927712_2 1396418.BATQ01000049_gene425 9.527e-33 134.0 COG2606@1|root,COG2606@2|Bacteria,46VWQ@74201|Verrucomicrobia,2IUV0@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Aminoacyl-tRNA editing domain - - - - - - - - - - - - tRNA_edit CMS1_k127_2927712_0 204669.Acid345_2395 6.246e-201 650.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K08282,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16,TPR_2,TPR_8 CMS1_k127_2927712_4 1112212.JH584235_gene1458 9.728e-05 45.0 2CVTP@1|root,32SY9@2|Bacteria,1N209@1224|Proteobacteria,2UC8J@28211|Alphaproteobacteria,2K5GB@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1203) - - - - - - - - - - - - DUF1203 CMS1_k127_2927712_3 1123377.AUIV01000006_gene1574 1.195e-08 56.0 COG2032@1|root,COG2032@2|Bacteria,1N26J@1224|Proteobacteria,1S8WE@1236|Gammaproteobacteria,1XC3N@135614|Xanthomonadales 135614|Xanthomonadales P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 - - - ko00000,ko00001,ko01000 - - - Sod_Cu CMS1_k127_2947011_0 1379698.RBG1_1C00001G1696 6.705e-46 181.0 COG0590@1|root,COG0590@2|Bacteria,2NPM7@2323|unclassified Bacteria 2|Bacteria FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.1,3.5.4.33 ko:K01485,ko:K11991 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922,R10223 RC00074,RC00477,RC00514,RC00809 ko00000,ko00001,ko01000,ko03016 - - - MafB19-deam CMS1_k127_2947011_1 1121935.AQXX01000142_gene2266 0.0009687 42.0 2DSB0@1|root,33FBC@2|Bacteria,1NGBC@1224|Proteobacteria,1SH3C@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_2950311_0 234267.Acid_0040 3.49e-164 524.0 COG1960@1|root,COG1960@2|Bacteria,3Y2FM@57723|Acidobacteria 57723|Acidobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_2950311_2 404589.Anae109_0137 5.252e-06 59.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WNXT@28221|Deltaproteobacteria,2YV4W@29|Myxococcales 28221|Deltaproteobacteria EGP of the major facilitator superfamily agmP - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1,MFS_1_like,Sugar_tr CMS1_k127_2950311_1 639030.JHVA01000001_gene918 5.025e-137 447.0 COG2256@1|root,COG2256@2|Bacteria,3Y3F7@57723|Acidobacteria,2JIAH@204432|Acidobacteriia 204432|Acidobacteriia L AAA ATPase - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N CMS1_k127_2957208_0 40571.JOEA01000029_gene5798 1.818e-11 77.0 COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4E27C@85010|Pseudonocardiales 201174|Actinobacteria T Tetratricopeptide repeat afsR - - - - - - - - - - - BTAD,CHAT,NB-ARC,TPR_10,TPR_12,TPR_7,Trans_reg_C CMS1_k127_2959976_0 1047013.AQSP01000125_gene2627 6.903e-109 362.0 COG2120@1|root,COG2120@2|Bacteria 2|Bacteria S N-acetylglucosaminylinositol deacetylase activity mca - - ko:K22136 - - - - ko00000 - - - NPCBM_assoc,PIG-L CMS1_k127_2959976_1 682795.AciX8_3374 1.692e-33 138.0 COG2318@1|root,COG2318@2|Bacteria,3Y569@57723|Acidobacteria,2JMW6@204432|Acidobacteriia 204432|Acidobacteriia S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_2959976_3 1384054.N790_01345 1.564e-17 93.0 COG1309@1|root,COG1309@2|Bacteria,1RCI9@1224|Proteobacteria,1SYP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS1_k127_2959976_2 1278073.MYSTI_02736 5.391e-20 102.0 COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria 1224|Proteobacteria G Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 CMS1_k127_296024_0 880073.Calab_3657 5.703e-136 453.0 COG0608@1|root,COG0608@2|Bacteria,2NNRX@2323|unclassified Bacteria 2|Bacteria L single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 CMS1_k127_296024_9 1379698.RBG1_1C00001G0068 1.883e-52 190.0 COG1839@1|root,COG1839@2|Bacteria,2NPAQ@2323|unclassified Bacteria 2|Bacteria S Adenosine specific kinase - - - ko:K09129 - - - - ko00000 - - - Adenosine_kin CMS1_k127_296024_11 240015.ACP_2680 1.247e-29 128.0 COG1028@1|root,COG1028@2|Bacteria,3Y3CD@57723|Acidobacteria,2JHIF@204432|Acidobacteriia 204432|Acidobacteriia IQ KR domain - - - - - - - - - - - - adh_short_C2 CMS1_k127_296024_4 644966.Tmar_0464 1.386e-122 401.0 COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,249PW@186801|Clostridia,3WCSA@538999|Clostridiales incertae sedis 186801|Clostridia G Bacterial fructose-1,6-bisphosphatase, glpX-encoded glpX - 3.1.3.11 ko:K02446 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX CMS1_k127_296024_8 518766.Rmar_0672 2.905e-56 206.0 COG2120@1|root,COG2120@2|Bacteria,4NEDJ@976|Bacteroidetes,1FIXS@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S GlcNAc-PI de-N-acetylase bshB1 - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L CMS1_k127_296024_1 1379698.RBG1_1C00001G0875 7.619e-130 435.0 COG3958@1|root,COG3958@2|Bacteria,2NQFH@2323|unclassified Bacteria 2|Bacteria G Transketolase, pyrimidine binding domain tktC - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C CMS1_k127_296024_5 1379698.RBG1_1C00001G0874 1.353e-114 377.0 COG3959@1|root,COG3959@2|Bacteria,2NP12@2323|unclassified Bacteria 2|Bacteria G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N CMS1_k127_296024_7 1267535.KB906767_gene2215 8.64e-71 259.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity - - - - - - - - - - - - Epimerase CMS1_k127_296024_13 590998.Celf_3110 3.368e-10 71.0 COG0500@1|root,COG2226@2|Bacteria,2IDNA@201174|Actinobacteria 201174|Actinobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_25 CMS1_k127_296024_12 671143.DAMO_0343 5.688e-11 68.0 COG1314@1|root,COG1314@2|Bacteria,2NPYV@2323|unclassified Bacteria 2|Bacteria U Preprotein translocase SecG subunit secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG CMS1_k127_296024_10 1038859.AXAU01000001_gene3049 1.464e-50 195.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,3JRGS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM CMS1_k127_296024_2 580331.Thit_1554 2.631e-124 409.0 COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales 186801|Clostridia F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK CMS1_k127_296024_3 1242864.D187_005685 2.701e-124 410.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2YUMG@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N CMS1_k127_296024_6 1191523.MROS_2233 4.331e-77 262.0 COG0205@1|root,COG0205@2|Bacteria 2|Bacteria G 6-phosphofructokinase activity pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK CMS1_k127_2963193_0 1449049.JONW01000005_gene1372 4.289e-25 117.0 2DN1Y@1|root,32V1U@2|Bacteria,1N3VE@1224|Proteobacteria,2UCDY@28211|Alphaproteobacteria,2KISB@204458|Caulobacterales 204458|Caulobacterales - - - - - - - - - - - - - - - CMS1_k127_2971010_3 1128421.JAGA01000002_gene1141 1.42e-56 224.0 COG1024@1|root,COG1024@2|Bacteria,2NR3A@2323|unclassified Bacteria 2|Bacteria I Enoyl-CoA hydratase/isomerase atuE - 4.2.1.18,4.2.1.57 ko:K13766,ko:K13779 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R02085,R03493 RC00941,RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_2971010_0 1382306.JNIM01000001_gene2570 2.401e-235 738.0 COG4799@1|root,COG4799@2|Bacteria,2G61R@200795|Chloroflexi 200795|Chloroflexi I PFAM carboxyl transferase - - 2.1.3.15,6.4.1.3,6.4.1.4 ko:K01969,ko:K15052 ko00280,ko00720,ko01100,ko01200,map00280,map00720,map01100,map01200 M00036,M00376 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans CMS1_k127_2971010_2 671143.DAMO_0966 6.049e-111 370.0 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 spoIVFB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K06212,ko:K06402 - - - - ko00000,ko01000,ko01002,ko02000 1.A.16.1.1,1.A.16.1.3 - - CBS,Form_Nir_trans,Peptidase_M50 CMS1_k127_2971010_5 1382359.JIAL01000001_gene450 2.5e-11 74.0 COG2948@1|root,COG2948@2|Bacteria,3Y81Q@57723|Acidobacteria,2JN9S@204432|Acidobacteriia 204432|Acidobacteriia U multi-organism process - - - ko:K03195 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - TrbI CMS1_k127_2971010_1 927658.AJUM01000034_gene68 6.452e-172 563.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,2FN1K@200643|Bacteroidia,3XJPB@558415|Marinilabiliaceae 976|Bacteroidetes EU Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_2971010_4 572547.Amico_0189 1.239e-35 141.0 COG1503@1|root,COG1503@2|Bacteria,3TC3W@508458|Synergistetes 508458|Synergistetes J translation release factor activity - - - - - - - - - - - - - CMS1_k127_2973700_1 1121271.AUCM01000004_gene1009 3.902e-37 145.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG CMS1_k127_2973700_2 292459.STH508 5.71e-19 97.0 COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia 186801|Clostridia J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA CMS1_k127_2973700_3 290397.Adeh_0718 5.615e-16 80.0 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,42V6T@68525|delta/epsilon subdivisions,2WRAX@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 CMS1_k127_2973700_0 518766.Rmar_0730 2.349e-56 213.0 COG1193@1|root,COG1193@2|Bacteria,4NFE6@976|Bacteroidetes,1FIM7@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr CMS1_k127_2974861_1 1125863.JAFN01000001_gene1608 1.953e-42 165.0 COG0457@1|root,COG0457@2|Bacteria,1N5BD@1224|Proteobacteria,42U63@68525|delta/epsilon subdivisions,2WQUR@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TPR repeat - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8 CMS1_k127_2974861_0 717605.Theco_2029 1.957e-102 345.0 COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,4HF29@91061|Bacilli,26R1J@186822|Paenibacillaceae 91061|Bacilli J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 CMS1_k127_298462_1 309807.SRU_0998 4.875e-45 176.0 COG0438@1|root,COG0438@2|Bacteria,4NE6S@976|Bacteroidetes,1FIXH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 CMS1_k127_298462_2 1379698.RBG1_1C00001G0387 4.749e-36 142.0 COG2001@1|root,COG2001@2|Bacteria,2NPTY@2323|unclassified Bacteria 2|Bacteria K MraZ protein, putative antitoxin-like mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ CMS1_k127_298462_4 378806.STAUR_6271 0.0004807 51.0 COG1366@1|root,COG1366@2|Bacteria 2|Bacteria T antisigma factor binding - - - - - - - - - - - - PAS_4,STAS,STAS_2 CMS1_k127_298462_0 1254432.SCE1572_10480 3.021e-64 236.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,2YUXX@29|Myxococcales 28221|Deltaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 CMS1_k127_298462_3 1144275.COCOR_06101 6.626e-25 115.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2YTT3@29|Myxococcales 28221|Deltaproteobacteria M penicillin-binding protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase CMS1_k127_2997153_1 1379698.RBG1_1C00001G0616 1.999e-44 169.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - - - - - - - - - - F5_F8_type_C,Peptidase_M6 CMS1_k127_2997153_3 1445613.JALM01000005_gene1186 9.521e-26 117.0 COG0346@1|root,COG0346@2|Bacteria,2H5Y5@201174|Actinobacteria,4EBMJ@85010|Pseudonocardiales 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase CMS1_k127_2997153_0 1996.JOFO01000017_gene5786 5.505e-87 296.0 COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4EIZN@85012|Streptosporangiales 201174|Actinobacteria S O-methyltransferase - - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 CMS1_k127_2997153_2 1267535.KB906767_gene3861 2.768e-44 167.0 COG4103@1|root,COG4103@2|Bacteria 2|Bacteria T Tellurite resistance protein TerB - - - - - - - - - - - - TerB CMS1_k127_2997153_5 1382303.JPOM01000001_gene370 1.32e-23 112.0 COG1266@1|root,COG1266@2|Bacteria,1MY1N@1224|Proteobacteria,2U3EH@28211|Alphaproteobacteria,2KFR8@204458|Caulobacterales 204458|Caulobacterales S PFAM Abortive infection protein - - - ko:K07052 - - - - ko00000 - - - Abi CMS1_k127_2997153_4 290512.Paes_0658 4.053e-25 110.0 COG1544@1|root,COG1544@2|Bacteria,1FFAZ@1090|Chlorobi 1090|Chlorobi J Sigma 54 modulation protein / S30EA ribosomal protein - - - - - - - - - - - - Ribosomal_S30AE CMS1_k127_3000101_2 1121428.DESHY_60241___1 1.019e-81 282.0 COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,260DU@186807|Peptococcaceae 186801|Clostridia F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C CMS1_k127_3000101_3 590998.Celf_0278 1.431e-26 128.0 COG0251@1|root,COG0251@2|Bacteria,2IFCR@201174|Actinobacteria,4F1MC@85016|Cellulomonadaceae 201174|Actinobacteria J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP CMS1_k127_3000101_0 880073.Calab_0773 4.877e-244 767.0 COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria 2|Bacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iAF987.Gmet_1487 GATase_6,SIS CMS1_k127_3000101_1 861299.J421_3894 2.999e-115 387.0 COG1109@1|root,COG1109@2|Bacteria,1ZSNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS1_k127_3002559_1 1379698.RBG1_1C00001G0415 3.169e-109 397.0 COG5316@1|root,COG5316@2|Bacteria,2NPBR@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 CMS1_k127_3002559_0 760568.Desku_0403 5.56e-311 976.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,25ZYN@186807|Peptococcaceae 186801|Clostridia J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 CMS1_k127_3002559_2 1303518.CCALI_00707 1.811e-62 226.0 COG2316@1|root,COG2316@2|Bacteria 2|Bacteria J Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06951 - - - - ko00000 - - - HD CMS1_k127_3002559_6 224324.aq_239 5.493e-21 106.0 COG0302@1|root,COG0302@2|Bacteria,2G40B@200783|Aquificae 200783|Aquificae H GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI CMS1_k127_3002559_5 1382304.JNIL01000001_gene3172 4.646e-24 111.0 COG1216@1|root,COG1216@2|Bacteria,1TP40@1239|Firmicutes,4HDDN@91061|Bacilli 91061|Bacilli S COG0463, glycosyltransferases involved in cell wall biogenesis ywdF GO:0003674,GO:0003824,GO:0016740,GO:0016757 - - - - - - - - - - Glycos_transf_2 CMS1_k127_3002559_4 1157490.EL26_19490 2.311e-50 198.0 COG0492@1|root,COG0492@2|Bacteria,1V4WN@1239|Firmicutes,4HHA8@91061|Bacilli,278DV@186823|Alicyclobacillaceae 91061|Bacilli C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_3002559_3 485913.Krac_12347 1.625e-52 193.0 COG0596@1|root,COG0596@2|Bacteria,2G6VQ@200795|Chloroflexi 2|Bacteria S PFAM alpha beta hydrolase fold MA20_20400 - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1,Abhydrolase_6 CMS1_k127_3007167_3 485915.Dret_1750 2.091e-63 223.0 COG0021@1|root,COG0021@2|Bacteria 2|Bacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_N,XFP,XFP_N CMS1_k127_3007167_4 545276.KB898728_gene139 4.275e-21 109.0 COG3258@1|root,COG3258@2|Bacteria,1MZJW@1224|Proteobacteria,1S2EF@1236|Gammaproteobacteria,1WY2H@135613|Chromatiales 135613|Chromatiales C Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 CMS1_k127_3007167_1 290397.Adeh_3164 8.991e-138 464.0 COG0520@1|root,COG0520@2|Bacteria,1Q61V@1224|Proteobacteria,42Y6K@68525|delta/epsilon subdivisions,2WTM3@28221|Deltaproteobacteria,2YV12@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 CMS1_k127_3007167_2 1128421.JAGA01000002_gene1518 1.854e-106 350.0 COG3483@1|root,COG3483@2|Bacteria 2|Bacteria E tryptophan 2,3-dioxygenase activity kynA GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 ko:K00453 ko00380,ko01100,map00380,map01100 M00038 R00678 RC00356 ko00000,ko00001,ko00002,ko01000 - - - Trp_dioxygenase CMS1_k127_3007167_0 1380394.JADL01000024_gene101 2.601e-286 891.0 COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2JRCI@204441|Rhodospirillales 204441|Rhodospirillales CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - 1.14.13.40 ko:K09461 ko00627,ko01120,map00627,map01120 - R03998,R03999 RC00244 ko00000,ko00001,ko01000 - - - FAD_binding_3,Oxidored_FMN CMS1_k127_301377_4 452637.Oter_1314 1.134e-37 152.0 COG5507@1|root,COG5507@2|Bacteria,46VQ8@74201|Verrucomicrobia,3K9QM@414999|Opitutae 414999|Opitutae S Protein of unknown function (DUF1428) - - - - - - - - - - - - DUF1428 CMS1_k127_301377_8 886293.Sinac_1889 1.531e-06 59.0 COG1595@1|root,COG1595@2|Bacteria,2IZFC@203682|Planctomycetes 203682|Planctomycetes K RNA polymerase sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_ECF,Sigma70_r2,Sigma70_r4_2 CMS1_k127_301377_2 234267.Acid_7851 4.741e-93 335.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria 57723|Acidobacteria K Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_301377_3 1123258.AQXZ01000019_gene3001 5.739e-38 164.0 COG0515@1|root,COG2909@1|root,COG0515@2|Bacteria,COG2909@2|Bacteria,2GIW5@201174|Actinobacteria,4FXQV@85025|Nocardiaceae 201174|Actinobacteria KLT Serine threonine-protein kinase pknK - - 2.7.11.1 ko:K13419 - - - - ko00000,ko01000,ko01001 - - - AAA_16,Pkinase,TPR_12 CMS1_k127_301377_7 459349.CLOAM0602 5.841e-17 97.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - 3.4.17.22 ko:K07752 - - - - ko00000,ko01000,ko01002 - - - Cellulase,DUF4859,F5_F8_type_C,FlgD_ig CMS1_k127_301377_5 1121104.AQXH01000001_gene1671 1.81e-36 161.0 COG1520@1|root,COG1572@1|root,COG2706@1|root,COG3391@1|root,COG5184@1|root,COG1520@2|Bacteria,COG1572@2|Bacteria,COG2706@2|Bacteria,COG3391@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - CHU_C,DUF11,DUF4347,VCBS CMS1_k127_301377_6 1121924.ATWH01000003_gene1578 4.851e-26 113.0 2FCGD@1|root,344JU@2|Bacteria,2IRV1@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_301377_0 1120972.AUMH01000004_gene1492 1.362e-143 462.0 COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli 91061|Bacilli C Aldo keto reductase - - - - - - - - - - - - Aldo_ket_red CMS1_k127_301377_1 744872.Spica_0573 5.623e-130 431.0 COG0707@1|root,COG0707@2|Bacteria,2J9T2@203691|Spirochaetes 203691|Spirochaetes M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) - - - - - - - - - - - - - CMS1_k127_3013885_11 861299.J421_0551 5.34e-24 113.0 2DNQD@1|root,32YJR@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3303) - - - - - - - - - - - - DUF3303 CMS1_k127_3013885_3 1499967.BAYZ01000156_gene556 6.696e-59 220.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.222,2.1.1.64 ko:K00568,ko:K20444 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 CMS1_k127_3013885_7 671143.DAMO_2282 1.487e-47 183.0 COG3189@1|root,COG3189@2|Bacteria 2|Bacteria K MarR family transcriptional regulator yeaO - - - - - - - - - - - DUF488 CMS1_k127_3013885_9 1242864.D187_006184 3.51e-35 149.0 COG3153@1|root,COG3153@2|Bacteria,1RA42@1224|Proteobacteria,4376W@68525|delta/epsilon subdivisions,2X277@28221|Deltaproteobacteria,2Z1SB@29|Myxococcales 28221|Deltaproteobacteria S Acetyltransferase (GNAT) domain - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_9 CMS1_k127_3013885_6 861299.J421_3860 1.13e-47 186.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DUF1572 CMS1_k127_3013885_8 314225.ELI_00725 3.657e-37 147.0 COG0454@1|root,COG0456@2|Bacteria,1RA6D@1224|Proteobacteria,2UC27@28211|Alphaproteobacteria,2K5HT@204457|Sphingomonadales 204457|Sphingomonadales K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_3013885_4 1267535.KB906767_gene891 1.235e-53 193.0 COG2318@1|root,COG2318@2|Bacteria,3Y5DP@57723|Acidobacteria 57723|Acidobacteria S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_3013885_12 32049.SYNPCC7002_A0416 8.694e-19 91.0 COG2518@1|root,COG2518@2|Bacteria 2|Bacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - Methyltransf_25,Methyltransf_31,rRNA_methylase CMS1_k127_3013885_0 1121939.L861_17285 1.794e-238 744.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C FAD linked oxidase domain protein - - - - - - - - - - - - BBE,FAD_binding_4 CMS1_k127_3013885_1 1210884.HG799469_gene13923 3.954e-119 396.0 COG0388@1|root,COG0388@2|Bacteria,2J2IE@203682|Planctomycetes 203682|Planctomycetes S Carbon-nitrogen hydrolase - - - - - - - - - - - - CN_hydrolase CMS1_k127_3013885_5 485913.Krac_2610 7.772e-51 203.0 COG2513@1|root,COG2513@2|Bacteria 2|Bacteria G methylisocitrate lyase activity MA20_35565 - 4.1.3.30 ko:K03417 ko00640,map00640 - R00409 RC00286,RC00287 ko00000,ko00001,ko01000 - - - PEP_mutase CMS1_k127_3013885_2 1159870.KB907784_gene393 5.166e-110 367.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VHZV@28216|Betaproteobacteria 28216|Betaproteobacteria C Dehydrogenase - - 1.1.99.31 ko:K15054 ko00627,ko01120,map00627,map01120 - R04160,R07664 RC00240 ko00000,ko00001,ko01000 - - - FMN_dh CMS1_k127_301591_2 84751.XP_007882496.1 1.404e-07 63.0 KOG1217@1|root,KOG1217@2759|Eukaryota,38DMI@33154|Opisthokonta,3PF4P@4751|Fungi,3V643@5204|Basidiomycota 4751|Fungi T Si dkey-21a6.5 - - - - - - - - - - - - Ephrin_rec_like CMS1_k127_301591_1 1242864.D187_001393 4.362e-35 156.0 COG2234@1|root,COG3291@1|root,COG2234@2|Bacteria,COG3291@2|Bacteria,1MXJC@1224|Proteobacteria,42RKA@68525|delta/epsilon subdivisions,2WUCM@28221|Deltaproteobacteria,2YWU8@29|Myxococcales 28221|Deltaproteobacteria S Peptidase family M28 - - 3.4.11.10 ko:K05994 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M28 CMS1_k127_301591_0 215803.DB30_2423 6.205e-117 414.0 COG1404@1|root,COG3291@1|root,COG3509@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria,2YZ9E@29|Myxococcales 28221|Deltaproteobacteria OQ Bacterial Ig-like domain (group 3) - - - - - - - - - - - - Big_3_2,Big_3_3,Inhibitor_I9,Peptidase_S8 CMS1_k127_3018720_3 56780.SYN_01010 4.209e-07 55.0 COG1538@1|root,COG1538@2|Bacteria,1PTZ6@1224|Proteobacteria,42RK2@68525|delta/epsilon subdivisions,2WNMB@28221|Deltaproteobacteria,2MS0Y@213462|Syntrophobacterales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS1_k127_3018720_2 1379698.RBG1_1C00001G1364 2.069e-86 302.0 COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family macA - - ko:K02005,ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP CMS1_k127_3018720_0 945713.IALB_1699 4.288e-92 321.0 COG1136@1|root,COG1136@2|Bacteria 2|Bacteria V lipoprotein transporter activity macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_3018720_1 1047013.AQSP01000140_gene2537 2.818e-91 325.0 COG0577@1|root,COG0577@2|Bacteria,2NQMU@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_3024611_2 1242864.D187_008407 7.045e-109 359.0 COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,42MZG@68525|delta/epsilon subdivisions,2WKZ3@28221|Deltaproteobacteria,2YTT5@29|Myxococcales 28221|Deltaproteobacteria A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert CMS1_k127_3024611_1 1242864.D187_008408 5.165e-193 610.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42PKM@68525|delta/epsilon subdivisions,2WJCP@28221|Deltaproteobacteria,2YUCG@29|Myxococcales 28221|Deltaproteobacteria S tRNA-splicing ligase RtcB rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB CMS1_k127_3024611_0 1254432.SCE1572_41675 4.975e-242 758.0 COG4650@1|root,COG4650@2|Bacteria,1MX6U@1224|Proteobacteria,42NHB@68525|delta/epsilon subdivisions,2WKUB@28221|Deltaproteobacteria,2YTU9@29|Myxococcales 28221|Deltaproteobacteria K Sigma-54 dependent transcriptional regulator rtcR - - ko:K14414 - - - - ko00000,ko03000 - - - RtcR,Sigma54_activat CMS1_k127_3024611_3 1157708.KB907457_gene2582 6.889e-30 119.0 COG2425@1|root,COG2425@2|Bacteria,1R55U@1224|Proteobacteria,2VKRA@28216|Betaproteobacteria,4AC01@80864|Comamonadaceae 28216|Betaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K11089 ko05322,map05322 - - - ko00000,ko00001 - - - TROVE CMS1_k127_3025210_1 518766.Rmar_2194 8.911e-141 455.0 COG0160@1|root,COG0160@2|Bacteria,4NGPB@976|Bacteroidetes,1FITF@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lat - 2.6.1.36 ko:K03918 ko01100,map01100 - R00457 RC00006,RC00062 ko00000,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_3025210_3 435908.IDSA_04245 8.223e-32 132.0 COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,1RPGA@1236|Gammaproteobacteria,2QF4P@267893|Idiomarinaceae 1236|Gammaproteobacteria K acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system lrp GO:0000976,GO:0001067,GO:0001101,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009078,GO:0009080,GO:0009081,GO:0009082,GO:0009098,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016053,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046394,GO:0046395,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901698,GO:1901700,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24 CMS1_k127_3025210_0 1379698.RBG1_1C00001G1661 7.236e-184 587.0 COG1239@1|root,COG1239@2|Bacteria,2NQQG@2323|unclassified Bacteria 2|Bacteria H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX chlI - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - iNJ661.Rv0958 Mg_chelatase,Sigma54_activat CMS1_k127_3025210_2 1379698.RBG1_1C00001G1660 2.276e-118 412.0 COG4867@1|root,COG4867@2|Bacteria,2NQZ8@2323|unclassified Bacteria 2|Bacteria S von Willebrand factor (vWF) type A domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA_2 CMS1_k127_3044183_0 1403819.BATR01000053_gene1665 1.237e-56 206.0 COG0697@1|root,COG0697@2|Bacteria,46T3I@74201|Verrucomicrobia,2IVMP@203494|Verrucomicrobiae 203494|Verrucomicrobiae EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_3044183_1 886293.Sinac_2076 6.694e-49 179.0 COG1522@1|root,COG1522@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type CMS1_k127_3044183_3 1123519.PSJM300_04875 1.079e-29 124.0 2DNJV@1|root,32UJ6@2|Bacteria,1N4SS@1224|Proteobacteria,1SQYW@1236|Gammaproteobacteria,1Z47D@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_3044183_2 1267535.KB906767_gene341 3.495e-37 147.0 28JRZ@1|root,2Z9HI@2|Bacteria,3Y7HD@57723|Acidobacteria 57723|Acidobacteria S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 CMS1_k127_3044183_4 990073.ATHU01000001_gene764 4.781e-08 54.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 CMS1_k127_3049755_1 1384056.N787_09105 2.768e-08 65.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1X3EY@135614|Xanthomonadales 135614|Xanthomonadales M Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 CMS1_k127_3049755_0 1379698.RBG1_1C00001G0886 2.552e-54 199.0 COG1686@1|root,COG1686@2|Bacteria,2NPJT@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S11 family pbpG GO:0000003,GO:0000270,GO:0000910,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006022,GO:0006508,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016043,GO:0016787,GO:0019538,GO:0019954,GO:0022402,GO:0022414,GO:0030203,GO:0032505,GO:0042221,GO:0042493,GO:0042597,GO:0043093,GO:0043170,GO:0044238,GO:0044464,GO:0045229,GO:0050896,GO:0051301,GO:0070011,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564 3.4.16.4 ko:K01286,ko:K07258,ko:K07262 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - iECO103_1326.ECO103_2610,iYL1228.KPN_02573 Peptidase_S11 CMS1_k127_3079024_0 234267.Acid_4393 3.458e-31 139.0 COG0515@1|root,COG0515@2|Bacteria 234267.Acid_4393|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3079024_1 234267.Acid_2121 5.143e-12 71.0 COG0515@1|root,COG0515@2|Bacteria 234267.Acid_2121|- KLT protein kinase activity - - 2.7.11.1 ko:K08884 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_3092847_2 1121899.Q764_04580 4.741e-22 98.0 COG3662@1|root,COG3662@2|Bacteria,4NEYP@976|Bacteroidetes,1HWJP@117743|Flavobacteriia,2NUUE@237|Flavobacterium 976|Bacteroidetes S Uncharacterized protein conserved in bacteria (DUF2236) - - - - - - - - - - - - DUF2236 CMS1_k127_3092847_3 880073.Calab_2377 1.835e-09 71.0 COG1404@1|root,COG3637@1|root,COG1404@2|Bacteria,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety msp3 - - - - - - - - - - - SLH,Surface_Ag_2 CMS1_k127_3092847_0 644966.Tmar_0009 2.458e-143 466.0 COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,3WCCW@538999|Clostridiales incertae sedis 186801|Clostridia J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b CMS1_k127_3092847_1 1379698.RBG1_1C00001G1544 1.905e-84 295.0 COG4191@1|root,COG4191@2|Bacteria,2NPC5@2323|unclassified Bacteria 2|Bacteria T Integral membrane sensor signal transduction histidine kinase vicK - 2.1.1.80,2.7.13.3,3.1.1.61 ko:K07709,ko:K13924 ko02020,ko02030,map02020,map02030 M00499,M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA CMS1_k127_3101320_0 1379698.RBG1_1C00001G0172 1.426e-50 187.0 COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria 2|Bacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C CMS1_k127_3101320_1 644966.Tmar_0099 6.877e-43 164.0 COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WCIX@538999|Clostridiales incertae sedis 186801|Clostridia J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro CMS1_k127_3101320_3 1499967.BAYZ01000179_gene4640 2.21e-19 93.0 COG0360@1|root,COG0360@2|Bacteria,2NQ1Q@2323|unclassified Bacteria 2|Bacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 CMS1_k127_3101320_2 1120973.AQXL01000133_gene1807 6.282e-24 102.0 COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,4HKCC@91061|Bacilli,27AAM@186823|Alicyclobacillaceae 91061|Bacilli J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 CMS1_k127_3105946_0 459349.CLOAM1614 1.57e-20 104.0 COG1572@1|root,COG2931@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,2NR5X@2323|unclassified Bacteria 2|Bacteria Q FlgD Ig-like domain - - - - - - - - - - - - DUF1735,FlgD_ig,Laminin_G_3 CMS1_k127_3110089_2 351160.RRC418 1.912e-07 61.0 COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota 28890|Euryarchaeota G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like,MFS_3 CMS1_k127_3110089_1 414684.RC1_3102 2.958e-50 196.0 COG0665@1|root,COG0665@2|Bacteria,1N1TN@1224|Proteobacteria,2TR7B@28211|Alphaproteobacteria,2JR5H@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase - - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO CMS1_k127_3110089_0 1125863.JAFN01000001_gene2782 1.913e-69 250.0 COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,42S03@68525|delta/epsilon subdivisions,2WNW5@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM Coenzyme A transferase - - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans CMS1_k127_3111812_6 1379698.RBG1_1C00001G1786 2.161e-12 77.0 2CUTJ@1|root,32SW3@2|Bacteria,2NRD1@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_3111812_3 1379698.RBG1_1C00001G1787 8.235e-88 327.0 COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria,2NPRE@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - DUF1863,PQQ_2 CMS1_k127_3111812_4 1379698.RBG1_1C00001G1788 1.26e-49 189.0 COG2067@1|root,COG3292@1|root,COG2067@2|Bacteria,COG3292@2|Bacteria,2NPQZ@2323|unclassified Bacteria 2|Bacteria I Two component regulator propeller - - - - - - - - - - - - CHB_HEX_C_1,Reg_prop,Reprolysin_5,VCBS CMS1_k127_3111812_2 1379698.RBG1_1C00001G1789 6.789e-95 353.0 COG1572@1|root,COG1572@2|Bacteria,2NP03@2323|unclassified Bacteria 2|Bacteria S Propeptide_C25 porU - - - - - - - - - - - Peptidase_C25 CMS1_k127_3111812_5 648996.Theam_1326 3.127e-14 76.0 COG2835@1|root,COG2835@2|Bacteria,2G4D1@200783|Aquificae 200783|Aquificae S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p CMS1_k127_3111812_1 880073.Calab_1391 5.19e-125 408.0 COG0825@1|root,COG0825@2|Bacteria,2NNVQ@2323|unclassified Bacteria 2|Bacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA,Carboxyl_trans CMS1_k127_3111812_0 370438.PTH_2220 1.053e-216 697.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae 186801|Clostridia L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon CMS1_k127_3116022_0 671143.DAMO_0822 8.502e-85 292.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS1_k127_3116022_5 1162668.LFE_1500 2.661e-32 133.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - Cytochrome_C554,DUF11,SLH CMS1_k127_3116022_7 575540.Isop_1130 1.092e-14 83.0 COG0727@1|root,COG0727@2|Bacteria,2IZU5@203682|Planctomycetes 203682|Planctomycetes S PFAM Uncharacterised protein family (UPF0153) - - - - - - - - - - - - CxxCxxCC CMS1_k127_3116022_2 1051632.TPY_0663 2.156e-45 190.0 COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,248PD@186801|Clostridia 186801|Clostridia O Highly conserved protein containing a thioredoxin domain - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH CMS1_k127_3116022_3 1191523.MROS_1703 7.021e-38 158.0 COG2120@1|root,COG2120@2|Bacteria 2|Bacteria S N-acetylglucosaminylinositol deacetylase activity bshB1 - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L CMS1_k127_3116022_6 706587.Desti_4742 9.978e-25 108.0 2EH48@1|root,33AW7@2|Bacteria,1NIYU@1224|Proteobacteria,42XKK@68525|delta/epsilon subdivisions,2WSKU@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_3116022_9 1121405.dsmv_0766 0.0002488 47.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2WMS6@28221|Deltaproteobacteria,2MNJX@213118|Desulfobacterales 28221|Deltaproteobacteria CO Cytochrome C biogenesis protein transmembrane region dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 CMS1_k127_3116022_4 1379698.RBG1_1C00001G0750 4.596e-35 142.0 COG2143@1|root,COG2143@2|Bacteria 2|Bacteria O COG2143 Thioredoxin-related protein soxS - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - Thioredoxin_2,Thioredoxin_7 CMS1_k127_3116022_1 1382356.JQMP01000003_gene1869 1.057e-83 291.0 COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,27XGT@189775|Thermomicrobia 189775|Thermomicrobia J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C CMS1_k127_3116022_8 649639.Bcell_0321 5.757e-08 64.0 COG3595@1|root,COG3595@2|Bacteria,1VFBT@1239|Firmicutes,4HNV1@91061|Bacilli 91061|Bacilli S Putative adhesin - - - - - - - - - - - - DUF4097 CMS1_k127_312672_2 1379270.AUXF01000006_gene39 7.093e-46 184.0 COG1629@1|root,COG4771@2|Bacteria,1ZST4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P CarboxypepD_reg-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec CMS1_k127_312672_1 1379698.RBG1_1C00001G1403 3.899e-108 381.0 COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria 2|Bacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_2,GSDH CMS1_k127_312672_7 1379698.RBG1_1C00001G0592 1.678e-10 75.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - - - - - - - - - - HemolysinCabind CMS1_k127_312672_4 870187.Thini_0382 1.729e-34 139.0 COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,1SCIZ@1236|Gammaproteobacteria,463F1@72273|Thiotrichales 72273|Thiotrichales L PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 CMS1_k127_312672_0 1121920.AUAU01000024_gene2388 1.024e-188 636.0 COG3005@1|root,COG3043@1|root,COG3005@2|Bacteria,COG3043@2|Bacteria,3Y4BJ@57723|Acidobacteria 57723|Acidobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_312672_10 1162668.LFE_2144 0.0009742 51.0 COG1333@1|root,COG1333@2|Bacteria,3J0N7@40117|Nitrospirae 40117|Nitrospirae O ResB-like family - - - ko:K07399 - - - - ko00000 - - - ResB CMS1_k127_312672_8 589865.DaAHT2_0401 1.613e-05 59.0 COG3417@1|root,COG3417@2|Bacteria,1NVM9@1224|Proteobacteria,4307F@68525|delta/epsilon subdivisions,2WV4Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Peptidoglycan-synthase activator LpoB - - - - - - - - - - - - LpoB CMS1_k127_312672_5 404589.Anae109_1833 5.547e-18 91.0 COG4380@1|root,COG4380@2|Bacteria,1NJYS@1224|Proteobacteria,42X1E@68525|delta/epsilon subdivisions,2WTEE@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Putative bacterial lipoprotein (DUF799) - - - - - - - - - - - - DUF799 CMS1_k127_312672_3 880073.Calab_1263 1.069e-42 175.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_3146999_3 357808.RoseRS_0537 2.301e-10 62.0 COG2129@1|root,COG2129@2|Bacteria 2|Bacteria L metallophosphoesterase - - - ko:K07096 - - - - ko00000 - - - Metallophos,Metallophos_2,Metallophos_3 CMS1_k127_3146999_0 765911.Thivi_1789 5.086e-51 192.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,1WY3R@135613|Chromatiales 135613|Chromatiales F PFAM Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase CMS1_k127_3146999_1 1379701.JPJC01000227_gene2318 1.331e-22 99.0 COG1476@1|root,COG1476@2|Bacteria,1N6SS@1224|Proteobacteria,2UFFG@28211|Alphaproteobacteria,2K6RT@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 CMS1_k127_3146999_2 861299.J421_2976 6.927e-20 93.0 COG1657@1|root,COG1657@2|Bacteria,1ZSPV@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 CMS1_k127_3173708_1 1122176.KB903551_gene4232 7.71e-65 231.0 COG0463@1|root,COG0463@2|Bacteria,4NGYU@976|Bacteroidetes,1IU82@117747|Sphingobacteriia 976|Bacteroidetes M involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_3173708_3 479434.Sthe_0849 1.14e-47 191.0 COG0438@1|root,COG0438@2|Bacteria,2G8W3@200795|Chloroflexi,27Y3X@189775|Thermomicrobia 189775|Thermomicrobia M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4 CMS1_k127_3173708_2 1047013.AQSP01000138_gene1051 3.86e-56 222.0 COG0438@1|root,COG0438@2|Bacteria,2NPA0@2323|unclassified Bacteria 2|Bacteria M glycosyl transferase group 1 - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 CMS1_k127_3173708_0 648996.Theam_1716 3.439e-68 249.0 COG0750@1|root,COG0750@2|Bacteria,2G3QY@200783|Aquificae 200783|Aquificae M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 CMS1_k127_3173708_4 1125863.JAFN01000001_gene506 6.492e-43 179.0 COG4775@1|root,COG4775@2|Bacteria,1RJPJ@1224|Proteobacteria,42TA2@68525|delta/epsilon subdivisions,2WP1H@28221|Deltaproteobacteria 28221|Deltaproteobacteria M surface antigen - - - - - - - - - - - - Bac_surface_Ag,POTRA CMS1_k127_3176199_2 861299.J421_1983 1.593e-36 146.0 COG1538@1|root,COG1538@2|Bacteria,1ZT9S@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS1_k127_3176199_1 861299.J421_1982 6.785e-80 291.0 COG0845@1|root,COG0845@2|Bacteria,1ZU07@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 CMS1_k127_3176199_0 861299.J421_1981 3.198e-137 469.0 COG0577@1|root,COG0577@2|Bacteria,1ZSUJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_3176199_3 67267.JNXT01000038_gene3349 2.215e-27 118.0 COG2310@1|root,COG2340@1|root,COG2310@2|Bacteria,COG2340@2|Bacteria,2GNN0@201174|Actinobacteria 201174|Actinobacteria T Cysteine-rich secretory protein family - - - - - - - - - - - - CAP,TerD CMS1_k127_3179674_0 871968.DESME_03335 9.059e-129 422.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,2611H@186807|Peptococcaceae 186801|Clostridia C acyl-CoA dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_3179674_1 309801.trd_0440 2.215e-121 416.0 COG2006@1|root,COG2006@2|Bacteria,2GA2Y@200795|Chloroflexi,27YWH@189775|Thermomicrobia 189775|Thermomicrobia S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 CMS1_k127_3182035_0 1121875.KB907548_gene1486 4.837e-64 241.0 COG0793@1|root,COG4976@1|root,COG0793@2|Bacteria,COG4976@2|Bacteria,4NIS9@976|Bacteroidetes,1HZR4@117743|Flavobacteriia 976|Bacteroidetes M Methyltransferase - - - - - - - - - - - - Peptidase_S41 CMS1_k127_3182035_1 1120949.KB903296_gene9450 3.228e-08 63.0 COG1404@1|root,COG2382@1|root,COG3979@1|root,COG1404@2|Bacteria,COG2382@2|Bacteria,COG3979@2|Bacteria,2GV7P@201174|Actinobacteria 201174|Actinobacteria P esterase - - - - - - - - - - - - Esterase,He_PIG CMS1_k127_3184046_2 204669.Acid345_2716 8.785e-45 184.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS1_k127_3184046_1 1500894.JQNN01000001_gene2742 2.413e-83 286.0 COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_3184046_0 1279009.ADICEAN_01483 5.564e-90 315.0 COG0668@1|root,COG0668@2|Bacteria,4NFC6@976|Bacteroidetes,47YNQ@768503|Cytophagia 976|Bacteroidetes M Mechanosensitive ion channel mscM - - - - - - - - - - - MS_channel CMS1_k127_3199166_2 448385.sce6264 3.727e-07 63.0 COG4775@1|root,COG4775@2|Bacteria 2|Bacteria M membrane organization - - - - - - - - - - - - Bac_surface_Ag,CarboxypepD_reg,Laminin_G_3,POTRA CMS1_k127_3199166_0 309807.SRU_0977 2.799e-68 257.0 2AB2F@1|root,310G6@2|Bacteria,4PEZP@976|Bacteroidetes,1FJWS@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_3199166_1 1254432.SCE1572_37590 1.228e-54 219.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales 28221|Deltaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - - CMS1_k127_3202167_0 1379698.RBG1_1C00001G1649 5.323e-127 422.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,2NNYX@2323|unclassified Bacteria 2|Bacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 ko:K02372,ko:K02535,ko:K13599,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,ko02020,map00061,map00540,map00780,map01100,map01212,map02020 M00060,M00083,M00498,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005,ko02022 - - - FabA,LpxC CMS1_k127_3202167_1 1379698.RBG1_1C00001G1848 5.761e-97 334.0 COG1044@1|root,COG1044@2|Bacteria,2NNSF@2323|unclassified Bacteria 2|Bacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - ic_1306.c0216 Hexapep,Hexapep_2,LpxD CMS1_k127_3202167_2 1379698.RBG1_1C00001G1847 1.25e-20 96.0 COG2825@1|root,COG2825@2|Bacteria,2NQ6C@2323|unclassified Bacteria 2|Bacteria M Outer membrane protein (OmpH-like) ompH - - ko:K06142 - - - - ko00000 - - - OmpH CMS1_k127_32050_3 398511.BpOF4_04820 0.0007563 48.0 COG0316@1|root,COG0316@2|Bacteria,1V6IN@1239|Firmicutes,4HKN2@91061|Bacilli,1ZH92@1386|Bacillus 91061|Bacilli S Belongs to the HesB IscA family yutM - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn CMS1_k127_32050_0 1192034.CAP_5767 5.218e-37 146.0 COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,42VYV@68525|delta/epsilon subdivisions,2WRGQ@28221|Deltaproteobacteria,2Z0X7@29|Myxococcales 28221|Deltaproteobacteria K MerR, DNA binding - - - ko:K19591 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 CMS1_k127_32050_2 105425.BBPL01000079_gene4737 1.211e-06 56.0 COG3794@1|root,COG3794@2|Bacteria,2GS7W@201174|Actinobacteria,2NJFG@228398|Streptacidiphilus 201174|Actinobacteria C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Cupredoxin_1 CMS1_k127_32050_1 426114.THI_0985 3.295e-08 64.0 COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2VX9Q@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Cupredoxin_1 CMS1_k127_3205098_3 1379698.RBG1_1C00001G1850 2.555e-34 141.0 COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria 2|Bacteria S Rhomboid family - - - - - - - - - - - - Rhomboid CMS1_k127_3205098_2 945713.IALB_0376 2.198e-65 240.0 COG1207@1|root,COG1207@2|Bacteria 2|Bacteria M glucosamine-1-phosphate N-acetyltransferase activity glmU - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_4 CMS1_k127_3205098_0 290397.Adeh_1870 1.74e-107 368.0 COG1196@1|root,COG1196@2|Bacteria,1R3XQ@1224|Proteobacteria,42YF5@68525|delta/epsilon subdivisions,2WUDV@28221|Deltaproteobacteria,2YUE5@29|Myxococcales 28221|Deltaproteobacteria D HAD superfamily (subfamily IG) hydrolase 5'-Nucleotidase - - - - - - - - - - - - 5_nucleotid CMS1_k127_3205098_1 502025.Hoch_0564 2.424e-68 252.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2YWB2@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_3205098_4 404589.Anae109_2782 4.022e-12 68.0 COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,42MGR@68525|delta/epsilon subdivisions,2X5KV@28221|Deltaproteobacteria,2YY40@29|Myxococcales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_3218759_1 383372.Rcas_2697 4.047e-21 99.0 COG1595@1|root,COG1595@2|Bacteria,2G99U@200795|Chloroflexi 200795|Chloroflexi K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_3218759_0 1121324.CLIT_2c03230 2.699e-62 225.0 COG2998@1|root,COG2998@2|Bacteria,1V9V8@1239|Firmicutes,25H3U@186801|Clostridia 186801|Clostridia H Copper amine oxidase N-terminal domain - - - - - - - - - - - - Cu_amine_oxidN1 CMS1_k127_3247302_0 639030.JHVA01000001_gene3341 3.811e-152 494.0 COG1027@1|root,COG1027@2|Bacteria,3Y3XS@57723|Acidobacteria,2JHYF@204432|Acidobacteriia 204432|Acidobacteriia E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 CMS1_k127_3259107_1 443143.GM18_3291 2.291e-76 271.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,42MJK@68525|delta/epsilon subdivisions,2WJ8V@28221|Deltaproteobacteria,43SW9@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,UbiA CMS1_k127_3259107_3 555088.DealDRAFT_0660 2.01e-31 139.0 COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,25B02@186801|Clostridia,42K0K@68298|Syntrophomonadaceae 186801|Clostridia I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase CMS1_k127_3259107_2 1387312.BAUS01000012_gene2167 1.858e-43 175.0 COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2VQ2F@28216|Betaproteobacteria,2KMBA@206350|Nitrosomonadales 206350|Nitrosomonadales F Belongs to the cytidylate kinase family. Type 1 subfamily cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin CMS1_k127_3259107_0 760568.Desku_1847 1.933e-104 359.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,2603K@186807|Peptococcaceae 186801|Clostridia E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase CMS1_k127_3259107_4 323261.Noc_0175 2.872e-23 103.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales 135613|Chromatiales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_3299410_1 631362.Thi970DRAFT_03186 7.551e-23 109.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,1X0B5@135613|Chromatiales 135613|Chromatiales M Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 CMS1_k127_3299410_4 448385.sce1897 2.355e-09 67.0 2AH4C@1|root,317DX@2|Bacteria,1PYQ3@1224|Proteobacteria,435H7@68525|delta/epsilon subdivisions,2WZUU@28221|Deltaproteobacteria,2Z2SV@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_3299410_6 331113.SNE_A18620 2.866e-08 59.0 2ENSK@1|root,33GDS@2|Bacteria,2JHH5@204428|Chlamydiae 204428|Chlamydiae - - - - - - - - - - - - - - - CMS1_k127_3299410_3 762903.Pedsa_1064 7.778e-14 83.0 COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia 976|Bacteroidetes MU Belongs to the ompA family - - - - - - - - - - - - OmpA,PD40,TPR_16,TPR_2,TPR_8 CMS1_k127_3299410_8 643867.Ftrac_0024 0.0007966 51.0 COG2885@1|root,COG2885@2|Bacteria,4NEND@976|Bacteroidetes,47KG7@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - OmpA,PD40 CMS1_k127_3299410_0 338966.Ppro_3460 3.057e-142 489.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,43AN8@68525|delta/epsilon subdivisions,2X62F@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - BTAD CMS1_k127_3299410_7 269799.Gmet_1690 1.428e-06 55.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,43UXK@69541|Desulfuromonadales 28221|Deltaproteobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM CMS1_k127_3299410_2 290397.Adeh_4236 3.281e-15 76.0 COG0491@1|root,COG0494@1|root,COG0491@2|Bacteria,COG0494@2|Bacteria,1MVC3@1224|Proteobacteria,430H1@68525|delta/epsilon subdivisions,2WVZX@28221|Deltaproteobacteria,2YUWZ@29|Myxococcales 28221|Deltaproteobacteria L Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,NUDIX CMS1_k127_3299410_5 1254432.SCE1572_06445 2.807e-08 57.0 COG1361@1|root,COG1361@2|Bacteria,1QVS6@1224|Proteobacteria,43C2E@68525|delta/epsilon subdivisions,2X7D0@28221|Deltaproteobacteria,2YTY3@29|Myxococcales 28221|Deltaproteobacteria M Conserved repeat domain - - - - - - - - - - - - Laminin_G_3 CMS1_k127_3302746_2 596152.DesU5LDRAFT_0623 1.006e-10 62.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MA4J@213115|Desulfovibrionales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran CMS1_k127_3302746_1 83406.HDN1F_09590 1.434e-20 99.0 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,1SCRA@1236|Gammaproteobacteria,1J7D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 CMS1_k127_3302746_0 926569.ANT_04400 6.604e-30 129.0 COG0454@1|root,COG1247@1|root,COG0456@2|Bacteria,COG1247@2|Bacteria,2G6N6@200795|Chloroflexi 200795|Chloroflexi K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_3338893_0 471857.Svir_01380 5.764e-74 274.0 COG1287@1|root,COG1287@2|Bacteria,2GMZM@201174|Actinobacteria,4E0ZH@85010|Pseudonocardiales 201174|Actinobacteria S oligosaccharyl transferase activity - - - - - - - - - - - - - CMS1_k127_3338893_2 187272.Mlg_0860 4.399e-07 62.0 COG4726@1|root,COG4726@2|Bacteria,1NQF4@1224|Proteobacteria 1224|Proteobacteria NU Pilus assembly protein PilX - - - - - - - - - - - - - CMS1_k127_3338893_1 56780.SYN_01756 9.167e-08 63.0 COG4726@1|root,COG4726@2|Bacteria,1NK1B@1224|Proteobacteria 1224|Proteobacteria NU Pilus assembly protein PilX - - - ko:K02673 - - - - ko00000,ko02035,ko02044 - - - PilX_N CMS1_k127_3346282_0 880073.Calab_0680 2.613e-33 136.0 COG1366@1|root,COG1366@2|Bacteria,2NR50@2323|unclassified Bacteria 2|Bacteria T Anti-sigma factor antagonist - - - ko:K04749,ko:K06378 - - - - ko00000,ko03021 - - - STAS,STAS_2 CMS1_k127_3346282_1 518766.Rmar_1340 1.509e-25 124.0 COG2304@1|root,COG2304@2|Bacteria,4NER3@976|Bacteroidetes,1FIZK@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - CMS1_k127_335143_0 351160.RRC418 9.785e-62 228.0 COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota 28890|Euryarchaeota G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like,MFS_3 CMS1_k127_335143_1 1380394.JADL01000011_gene3820 8.346e-32 141.0 COG1764@1|root,COG1764@2|Bacteria,1RHVR@1224|Proteobacteria,2VG83@28211|Alphaproteobacteria,2JTM8@204441|Rhodospirillales 204441|Rhodospirillales O OsmC-like protein - - - - - - - - - - - - OsmC CMS1_k127_3374970_3 247490.KSU1_C0449 2.451e-29 123.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - Cadherin_3,DUF4347,Peptidase_S8 CMS1_k127_3374970_1 1121920.AUAU01000004_gene672 4.207e-99 335.0 COG3342@1|root,COG3342@2|Bacteria,3Y80E@57723|Acidobacteria 57723|Acidobacteria S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028 CMS1_k127_3374970_0 99598.Cal7507_2382 4.485e-150 485.0 COG0372@1|root,COG0372@2|Bacteria,1G1DI@1117|Cyanobacteria,1HIJ1@1161|Nostocales 1117|Cyanobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - iJN678.gltA Citrate_synt CMS1_k127_3374970_4 1121033.AUCF01000001_gene2286 4.758e-09 67.0 COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,2TSN7@28211|Alphaproteobacteria,2JPCS@204441|Rhodospirillales 204441|Rhodospirillales S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 CMS1_k127_3374970_2 324602.Caur_0100 7.933e-47 174.0 COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,2G6N4@200795|Chloroflexi,375K6@32061|Chloroflexia 32061|Chloroflexia K iron dependent repressor - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress,FeoA CMS1_k127_3386036_7 383372.Rcas_0498 2.546e-48 190.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C CMS1_k127_3386036_2 32057.KB217478_gene3917 1.572e-83 293.0 COG0438@1|root,COG0438@2|Bacteria,1G4DC@1117|Cyanobacteria,1HQ2H@1161|Nostocales 1117|Cyanobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 CMS1_k127_3386036_4 1304880.JAGB01000001_gene942 1.234e-60 232.0 COG1215@1|root,COG1215@2|Bacteria,1UZRX@1239|Firmicutes,25H2F@186801|Clostridia 186801|Clostridia M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_3386036_14 1120950.KB892801_gene1666 2.287e-15 90.0 COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4DSH1@85009|Propionibacteriales 201174|Actinobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_3386036_10 1499967.BAYZ01000066_gene6072 4.505e-39 157.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.294,2.7.1.181 ko:K18827 - - R10657,R10658 RC00002,RC00003,RC00078,RC03220 ko00000,ko01000,ko01005 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 CMS1_k127_3386036_9 404589.Anae109_1820 1.144e-39 165.0 COG2456@1|root,COG2456@2|Bacteria,1NF5Z@1224|Proteobacteria,42VNI@68525|delta/epsilon subdivisions,2WS2M@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Uncharacterized conserved protein (DUF2304) - - - ko:K09153 - - - - ko00000 - - - DUF2304 CMS1_k127_3386036_1 290397.Adeh_3051 9.976e-103 340.0 COG1216@1|root,COG1216@2|Bacteria,1QW1K@1224|Proteobacteria,43BRI@68525|delta/epsilon subdivisions,2WN0V@28221|Deltaproteobacteria,2Z30Y@29|Myxococcales 28221|Deltaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_3386036_5 404589.Anae109_0677 1.122e-53 218.0 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,43AEY@68525|delta/epsilon subdivisions,2X5UP@28221|Deltaproteobacteria 28221|Deltaproteobacteria S SMART Tetratricopeptide domain protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 CMS1_k127_3386036_6 404589.Anae109_1840 5.976e-49 197.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 CMS1_k127_3386036_13 717231.Flexsi_1991 1.836e-18 95.0 COG3303@1|root,COG3303@2|Bacteria,2GG7G@200930|Deferribacteres 200930|Deferribacteres C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_3386036_11 1158338.JNLJ01000001_gene940 1.091e-35 155.0 COG3391@1|root,COG3391@2|Bacteria,2G4DB@200783|Aquificae 200783|Aquificae S NHL repeat containing protein - - - - - - - - - - - - DUF5128,NHL CMS1_k127_3386036_0 880073.Calab_1263 2.368e-111 393.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_3386036_12 395495.Lcho_4124 2.93e-30 138.0 COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,1MYI5@1224|Proteobacteria,2WEWP@28216|Betaproteobacteria 28216|Betaproteobacteria G 6-bladed beta-propeller - - - - - - - - - - - - NHL CMS1_k127_3386036_15 1035191.HMPREF0185_00375 1.174e-06 62.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2TVQD@28211|Alphaproteobacteria,2KG5E@204458|Caulobacterales 204458|Caulobacterales M peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 CMS1_k127_3386036_3 1121918.ARWE01000001_gene827 4.86e-72 265.0 COG3005@1|root,COG3005@2|Bacteria,1R8V7@1224|Proteobacteria,42YES@68525|delta/epsilon subdivisions,2WU80@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM cytochrome C family protein - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_3394891_0 694427.Palpr_1413 1.408e-58 218.0 COG2885@1|root,COG2885@2|Bacteria,4NE8J@976|Bacteroidetes 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - OMP_b-brl,OmpA,TSP_3 CMS1_k127_3394891_1 1179773.BN6_12470 1.247e-27 114.0 COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,4DXWC@85010|Pseudonocardiales 201174|Actinobacteria S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 CMS1_k127_3400417_0 1123371.ATXH01000010_gene759 3.171e-106 364.0 COG0082@1|root,COG0082@2|Bacteria,2GGRE@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt CMS1_k127_3400417_4 204669.Acid345_3339 1.263e-16 86.0 2DB97@1|root,32TX2@2|Bacteria,3Y59S@57723|Acidobacteria,2JJUG@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - CMS1_k127_3400417_2 1286171.EAL2_c13800 4.881e-28 119.0 COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia 186801|Clostridia L PFAM ribonuclease H rnhA - 3.1.26.4 ko:K03469,ko:K06864 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RVT_3 CMS1_k127_3400417_5 686578.AFFX01000005_gene4043 3.759e-14 86.0 COG1011@1|root,COG1011@2|Bacteria,1MWZZ@1224|Proteobacteria,1SI9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 CMS1_k127_3400417_1 330214.NIDE3119 5.977e-85 293.0 COG0491@1|root,COG0491@2|Bacteria,3J1C9@40117|Nitrospirae 40117|Nitrospirae S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B CMS1_k127_3420915_5 2325.TKV_c12510 0.0006108 48.0 COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,42F4N@68295|Thermoanaerobacterales 186801|Clostridia M PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase dacB1 - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 CMS1_k127_3420915_3 207559.Dde_2013 3.399e-18 96.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2M7YQ@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS1_k127_3420915_4 44056.XP_009034721.1 5.154e-09 68.0 KOG2156@1|root,KOG2156@2759|Eukaryota 2759|Eukaryota S protein polyglutamylation ttll-15 GO:0000003,GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0007610,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018094,GO:0018193,GO:0018200,GO:0018991,GO:0019098,GO:0019538,GO:0022414,GO:0032501,GO:0032504,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048609,GO:0070735,GO:0071704,GO:0140096,GO:1901564 6.3.2.25 ko:K06047,ko:K16601,ko:K16610,ko:K16770 - - - - ko00000,ko01000,ko03036,ko04812 - - - TTL CMS1_k127_3420915_1 383372.Rcas_3546 5.245e-83 306.0 COG0612@1|root,COG0612@2|Bacteria,2G68H@200795|Chloroflexi 200795|Chloroflexi S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_3420915_0 518766.Rmar_1348 9.734e-104 354.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_3420915_2 1379698.RBG1_1C00001G0178 6.612e-53 192.0 COG2265@1|root,COG2265@2|Bacteria,2NNWX@2323|unclassified Bacteria 2|Bacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr CMS1_k127_34417_1 1128421.JAGA01000001_gene2004 7.678e-192 606.0 COG1523@1|root,COG1523@2|Bacteria,2NPQU@2323|unclassified Bacteria 2|Bacteria G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) glgX - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 CMS1_k127_34417_0 886293.Sinac_5857 6.345e-252 814.0 COG0366@1|root,COG0366@2|Bacteria,2IYAN@203682|Planctomycetes 203682|Planctomycetes G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 CMS1_k127_34417_2 479434.Sthe_1091 1.853e-101 336.0 COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia 189775|Thermomicrobia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 CMS1_k127_3443340_1 404589.Anae109_4219 4.112e-125 415.0 COG0582@1|root,COG0582@2|Bacteria 2|Bacteria L DNA integration - - - ko:K07497 - - - - ko00000 - - - Phage_int_SAM_3,Phage_integrase CMS1_k127_3443340_8 1121396.KB893110_gene1903 2.264e-05 56.0 COG2885@1|root,COG3291@1|root,COG3866@1|root,COG5386@1|root,COG2885@2|Bacteria,COG3291@2|Bacteria,COG3866@2|Bacteria,COG5386@2|Bacteria,1PHGF@1224|Proteobacteria,4378N@68525|delta/epsilon subdivisions,2X9WI@28221|Deltaproteobacteria,2MN4C@213118|Desulfobacterales 28221|Deltaproteobacteria M PKD domain - - - - - - - - - - - - PKD CMS1_k127_3443340_2 502025.Hoch_5817 5.582e-93 332.0 COG1716@1|root,COG1716@2|Bacteria,1PYHH@1224|Proteobacteria,43DZM@68525|delta/epsilon subdivisions,2WZA1@28221|Deltaproteobacteria,2Z1P6@29|Myxococcales 28221|Deltaproteobacteria T Clostripain family - - - - - - - - - - - - Peptidase_C11 CMS1_k127_3443340_3 1120968.AUBX01000015_gene3509 1.682e-32 141.0 2ETUA@1|root,33MBM@2|Bacteria,4NYNV@976|Bacteroidetes 976|Bacteroidetes S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl_2 CMS1_k127_3443340_4 1120949.KB903332_gene9299 7.406e-22 100.0 COG0346@1|root,COG2267@1|root,COG0346@2|Bacteria,COG2267@2|Bacteria,2GMY4@201174|Actinobacteria,4DD4N@85008|Micromonosporales 201174|Actinobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 CMS1_k127_3443340_0 404589.Anae109_1051 1.523e-171 547.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2WKPM@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_3446062_3 1379698.RBG1_1C00001G0779 1.336e-22 113.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS1_k127_3446062_0 1379698.RBG1_1C00001G0780 5.194e-123 404.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B CMS1_k127_3446062_1 1379698.RBG1_1C00001G0781 5.619e-45 168.0 COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria 2|Bacteria C Rieske [2Fe-2S] domain petA - 1.10.2.2,1.10.9.1 ko:K00411,ko:K02636,ko:K03886 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - iAF987.Gmet_1922 CytB6-F_Fe-S,Rieske,UCR_Fe-S_N CMS1_k127_3446062_4 743719.PaelaDRAFT_1269 5.324e-22 107.0 COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,4HCCV@91061|Bacilli,26U28@186822|Paenibacillaceae 91061|Bacilli T PFAM response regulator receiver yhcZ - - - - - - - - - - - GerE,Response_reg CMS1_k127_3446062_2 331678.Cphamn1_2171 7.249e-24 102.0 COG1032@1|root,COG1032@2|Bacteria,1FEQY@1090|Chlorobi 1090|Chlorobi C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM CMS1_k127_3498374_0 591001.Acfer_1688 1.532e-81 280.0 COG1043@1|root,COG1043@2|Bacteria,1TQRI@1239|Firmicutes,4H2NG@909932|Negativicutes 909932|Negativicutes M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep,Hexapep_2 CMS1_k127_3498374_1 1379270.AUXF01000006_gene298 1.937e-60 231.0 COG0673@1|root,COG0673@2|Bacteria,1ZTES@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA CMS1_k127_3498374_2 1110502.TMO_1768 1.055e-56 222.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2TSEA@28211|Alphaproteobacteria,2JQPI@204441|Rhodospirillales 204441|Rhodospirillales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB CMS1_k127_3498374_3 545264.KB898746_gene783 1.585e-06 61.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales 135613|Chromatiales M PFAM Three-deoxy-D-manno-octulosonic-acid transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N,Kdo CMS1_k127_350728_0 234267.Acid_7636 6.546e-177 582.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria 57723|Acidobacteria KLTU Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40,Pkinase CMS1_k127_350728_4 926569.ANT_14650 2.879e-13 82.0 COG3255@1|root,COG3255@2|Bacteria,2G95B@200795|Chloroflexi 200795|Chloroflexi I SCP-2 sterol transfer family - - - - - - - - - - - - SCP2 CMS1_k127_350728_1 1278073.MYSTI_01610 8.077e-79 282.0 COG0277@1|root,COG0277@2|Bacteria,1Q3X2@1224|Proteobacteria,42YCF@68525|delta/epsilon subdivisions,2WTRU@28221|Deltaproteobacteria,2YYAW@29|Myxococcales 28221|Deltaproteobacteria C Cytokinin dehydrogenase 1, FAD and cytokinin binding - - - - - - - - - - - - Cytokin-bind,FAD_binding_4 CMS1_k127_350728_5 1120949.KB903317_gene1897 0.0003933 50.0 COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4DE55@85008|Micromonosporales 201174|Actinobacteria S Protein of unknown function (DUF664) - - - - - - - - - - - - DUF664,DinB_2 CMS1_k127_350728_3 1211115.ALIQ01000220_gene1435 1.223e-34 145.0 COG2010@1|root,COG2010@2|Bacteria,1RBTK@1224|Proteobacteria,2U6ME@28211|Alphaproteobacteria,3NB8J@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C CMS1_k127_350728_2 404589.Anae109_1011 1.889e-37 144.0 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2WSRV@28221|Deltaproteobacteria 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_351328_1 344747.PM8797T_00899 1.056e-172 554.0 COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 CMS1_k127_351328_0 502025.Hoch_4973 1.995e-179 581.0 COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2YUE6@29|Myxococcales 28221|Deltaproteobacteria L Deoxyribodipyrimidine photo-lyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 CMS1_k127_351328_3 391596.PBAL39_14649 2.032e-32 141.0 28HW2@1|root,2Z825@2|Bacteria,4NF6G@976|Bacteroidetes,1IPCM@117747|Sphingobacteriia 976|Bacteroidetes S Peptide-N-glycosidase F, N terminal - - - - - - - - - - - - DUF4412,N-glycanase_C,N-glycanase_N CMS1_k127_351328_4 523791.Kkor_1114 1.544e-28 115.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XM5A@135619|Oceanospirillales 135619|Oceanospirillales K cold-shock protein cspG - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS1_k127_351328_2 1121481.AUAS01000010_gene496 3.296e-46 190.0 COG2931@1|root,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia 976|Bacteroidetes Q SMART Integrin alpha beta-propellor repeat protein - - - - - - - - - - - - CHU_C,FG-GAP,HYR,VCBS CMS1_k127_351328_6 518766.Rmar_1484 0.0002544 54.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - FlgD_ig,Kelch_4 CMS1_k127_351977_4 393595.ABO_0521 4.082e-08 64.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1XI7D@135619|Oceanospirillales 135619|Oceanospirillales H COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_6,TPR_8 CMS1_k127_351977_2 59374.Fisuc_2018 7.015e-51 193.0 COG0571@1|root,COG0571@2|Bacteria 2|Bacteria J ribonuclease III activity rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm CMS1_k127_351977_0 997346.HMPREF9374_0894 1.654e-173 554.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,27B4D@186824|Thermoactinomycetaceae 91061|Bacilli IQ Beta-ketoacyl synthase, C-terminal domain fabF3 - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt CMS1_k127_351977_3 1379698.RBG1_1C00001G1825 7.615e-28 115.0 COG0236@1|root,COG0236@2|Bacteria,2NPVJ@2323|unclassified Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding CMS1_k127_351977_1 398767.Glov_1936 5.154e-77 263.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,43T1X@69541|Desulfuromonadales 28221|Deltaproteobacteria IQ KR domain fabG-2 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_353692_2 177439.DP0062 2.552e-32 128.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,42STM@68525|delta/epsilon subdivisions,2WPAD@28221|Deltaproteobacteria,2MKSG@213118|Desulfobacterales 28221|Deltaproteobacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 CMS1_k127_353692_4 1183438.GKIL_3240 5.811e-18 97.0 COG0612@1|root,COG0612@2|Bacteria,1G0D3@1117|Cyanobacteria 1117|Cyanobacteria S Peptidase family M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_353692_1 1449076.JOOE01000004_gene416 3.461e-88 310.0 COG0773@1|root,COG0773@2|Bacteria,1MVCG@1224|Proteobacteria,2TTDN@28211|Alphaproteobacteria,2K0S4@204457|Sphingomonadales 204457|Sphingomonadales M UDP-N-acetylmuramate-alanine ligase - - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M CMS1_k127_353692_0 771875.Ferpe_1995 9.726e-194 617.0 COG1012@1|root,COG1012@2|Bacteria,2GCJA@200918|Thermotogae 200918|Thermotogae C PFAM Aldehyde dehydrogenase - - 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh CMS1_k127_353692_3 368408.Tpen_1171 6.24e-21 104.0 arCOG14774@1|root,arCOG14774@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_356290_0 448385.sce6468 1.145e-19 96.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_ECF,Sigma70_r2,Sigma70_r4_2 CMS1_k127_356290_1 1172188.KB911820_gene3085 5.478e-16 87.0 28RB9@1|root,2ZDQU@2|Bacteria,2GZQK@201174|Actinobacteria,4FIZG@85021|Intrasporangiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_356290_2 319236.JCM19294_162 2.593e-05 48.0 COG0248@1|root,COG0248@2|Bacteria,4NEI0@976|Bacteroidetes,1HX36@117743|Flavobacteriia,3HK1C@363408|Nonlabens 976|Bacteroidetes FP Ppx/GppA phosphatase family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA CMS1_k127_3594431_1 344747.PM8797T_16523 1.559e-24 104.0 COG1764@1|root,COG1764@2|Bacteria,2IZAE@203682|Planctomycetes 203682|Planctomycetes O OsmC-like protein - - - ko:K04063 - - - - ko00000 - - - OsmC CMS1_k127_3594431_0 515635.Dtur_0001 9.363e-134 440.0 COG0593@1|root,COG0593@2|Bacteria 2|Bacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N CMS1_k127_3594431_3 944480.ATUV01000002_gene190 1.631e-11 66.0 COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,42WSU@68525|delta/epsilon subdivisions,2WSI8@28221|Deltaproteobacteria,2M7G3@213113|Desulfurellales 28221|Deltaproteobacteria J Ribosomal protein L34 rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 CMS1_k127_3594431_4 469383.Cwoe_5949 4.498e-07 57.0 COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria,4CQCA@84995|Rubrobacteria 84995|Rubrobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P CMS1_k127_3594431_2 640081.Dsui_0835 1.66e-21 101.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2VVTR@28216|Betaproteobacteria,2KX78@206389|Rhodocyclales 206389|Rhodocyclales S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic CMS1_k127_3600878_1 391623.TERMP_00992 3.18e-103 342.0 COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci 183968|Thermococci S CobW/HypB/UreG, nucleotide-binding domain - - - - - - - - - - - - cobW CMS1_k127_3600878_0 1122981.AUME01000058_gene688 8.245e-106 367.0 COG0045@1|root,COG0045@2|Bacteria,4NFHA@976|Bacteroidetes,2FNFG@200643|Bacteroidia 976|Bacteroidetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA CMS1_k127_3621223_0 1379698.RBG1_1C00001G1656 0.0 1040.0 COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW CMS1_k127_3621223_1 742738.HMPREF9460_02753 2.992e-80 275.0 COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,267TJ@186813|unclassified Clostridiales 186801|Clostridia L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom CMS1_k127_3621406_2 1121468.AUBR01000024_gene3049 3.576e-43 164.0 COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,42G21@68295|Thermoanaerobacterales 186801|Clostridia C electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF CMS1_k127_3621406_0 913865.DOT_4934 2.73e-88 301.0 COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,260BA@186807|Peptococcaceae 186801|Clostridia C electron transfer flavoprotein, alpha subunit etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha,Fer4 CMS1_k127_3621406_1 575540.Isop_1276 1.568e-54 198.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Dimerisation2,Methyltransf_11,Methyltransf_12,Methyltransf_2,Methyltransf_23 CMS1_k127_3621406_4 452637.Oter_2251 9.499e-28 125.0 COG0836@1|root,COG0836@2|Bacteria 2|Bacteria M mannose-1-phosphate guanylyltransferase activity manC - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase CMS1_k127_3621406_3 94624.Bpet1873 2.743e-42 161.0 COG3153@1|root,COG3153@2|Bacteria,1QTXW@1224|Proteobacteria,2WGH8@28216|Betaproteobacteria 28216|Betaproteobacteria S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_3621702_5 1048339.KB913029_gene3911 1.886e-36 141.0 COG1162@1|root,COG1162@2|Bacteria,2GMDX@201174|Actinobacteria,4EU3D@85013|Frankiales 201174|Actinobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase CMS1_k127_3621702_3 1444711.CCJF01000005_gene1555 1.546e-46 177.0 COG2071@1|root,COG2071@2|Bacteria,2JGVD@204428|Chlamydiae 204428|Chlamydiae S Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 CMS1_k127_3621702_2 765420.OSCT_0613 6.199e-47 186.0 COG0111@1|root,COG0111@2|Bacteria,2G6KY@200795|Chloroflexi,376P6@32061|Chloroflexia 32061|Chloroflexia C PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C CMS1_k127_3621702_1 251221.35211773 1.335e-112 397.0 COG4805@1|root,COG4805@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 CMS1_k127_3621702_6 1313172.YM304_23250 2.092e-28 127.0 COG0730@1|root,COG0730@2|Bacteria,2HGFT@201174|Actinobacteria,4CNDC@84992|Acidimicrobiia 84992|Acidimicrobiia S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_3621702_4 398767.Glov_3074 5.723e-42 173.0 COG4191@1|root,COG4191@2|Bacteria,1QUMH@1224|Proteobacteria,42MM2@68525|delta/epsilon subdivisions,2X7N8@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA CMS1_k127_3621702_0 290397.Adeh_0504 8.29e-115 406.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_3623854_0 404589.Anae109_2186 6.156e-222 698.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2YYDJ@29|Myxococcales 28221|Deltaproteobacteria C Isocitrate/isopropylmalate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS1_k127_3623854_1 404589.Anae109_1775 4.157e-21 95.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,42ZD0@68525|delta/epsilon subdivisions,2WU4P@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK CMS1_k127_3629213_0 485916.Dtox_2355 1.359e-125 418.0 COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,260AV@186807|Peptococcaceae 186801|Clostridia F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS1_k127_3629213_1 1121472.AQWN01000003_gene1402 1.703e-73 252.0 COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,261GH@186807|Peptococcaceae 186801|Clostridia F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - iHN637.CLJU_RS05275 Pribosyltran CMS1_k127_3630280_0 697282.Mettu_2758 4.486e-97 324.0 2DB8N@1|root,2Z7S9@2|Bacteria,1PZ8J@1224|Proteobacteria,1S1F6@1236|Gammaproteobacteria,1XGJV@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF3047) - - - - - - - - - - - - DUF3047 CMS1_k127_3630280_1 404589.Anae109_0109 4.684e-16 85.0 COG3153@1|root,COG3153@2|Bacteria,1NI24@1224|Proteobacteria 1224|Proteobacteria S Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_10 CMS1_k127_3630280_2 290397.Adeh_0105 2.712e-05 53.0 COG3153@1|root,COG3153@2|Bacteria 2|Bacteria S transferase activity, transferring acyl groups - - 2.3.1.189 ko:K15520 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_10 CMS1_k127_3631598_1 1158292.JPOE01000002_gene2015 6.044e-72 244.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,1KKHS@119065|unclassified Burkholderiales 28216|Betaproteobacteria P E1-E2 ATPase copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS CMS1_k127_3631598_2 290397.Adeh_0300 1.836e-23 105.0 COG4633@1|root,COG4633@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Cupredoxin_1,DsbD_2,HMA CMS1_k127_3631598_3 1191523.MROS_0783 4.318e-07 64.0 COG4244@1|root,COG4244@2|Bacteria 2|Bacteria E Membrane - - - - - - - - - - - - Cyt-b5,DUF2231,Fn3_assoc,PSCyt1,PSCyt2,PSD1 CMS1_k127_3631598_0 1192034.CAP_8124 0.0 1336.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2YUB0@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran CMS1_k127_3639293_1 234267.Acid_7523 2.587e-84 292.0 COG0612@1|root,COG0612@2|Bacteria,3Y322@57723|Acidobacteria 57723|Acidobacteria S Peptidase M16 inactive domain - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_3639293_2 443143.GM18_2087 1.838e-12 78.0 COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc CMS1_k127_3639293_0 644282.Deba_1534 1.283e-151 493.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_3641179_5 134676.ACPL_3725 4.545e-05 51.0 COG0366@1|root,COG1501@1|root,COG0366@2|Bacteria,COG1501@2|Bacteria,2GP4V@201174|Actinobacteria,4DADK@85008|Micromonosporales 201174|Actinobacteria G Belongs to the glycosyl hydrolase 31 family - - - - - - - - - - - - CBM_20,DUF5110,Glyco_hydro_31,NPCBM_assoc CMS1_k127_3641179_0 404589.Anae109_1840 8.403e-63 239.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 CMS1_k127_3641179_4 404589.Anae109_0690 6.078e-07 61.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2YTV4@29|Myxococcales 28221|Deltaproteobacteria U type IV pilus secretin PilQ pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N CMS1_k127_3641179_1 1133849.O3I_013130 1.063e-26 120.0 COG1073@1|root,COG1073@2|Bacteria,2I9HJ@201174|Actinobacteria,4FWIG@85025|Nocardiaceae 201174|Actinobacteria S Serine aminopeptidase, S33 - GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136 - ko:K06889 - - - - ko00000 - - - Hydrolase_4 CMS1_k127_3641179_3 1538295.JY96_18405 2.273e-13 76.0 COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2VQBM@28216|Betaproteobacteria,1KN9K@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function (DUF1211) - - - - - - - - - - - - DUF1211 CMS1_k127_3641179_2 1123393.KB891317_gene2319 3.257e-18 85.0 COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2VQBM@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF1211) - - - - - - - - - - - - DUF1211 CMS1_k127_3643679_1 1267533.KB906738_gene2351 1.426e-54 201.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C CMS1_k127_3643679_0 1250232.JQNJ01000001_gene3003 1.873e-98 334.0 COG1680@1|root,COG1680@2|Bacteria,4NRU6@976|Bacteroidetes,1I317@117743|Flavobacteriia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_3643679_2 981369.JQMJ01000004_gene4927 1.583e-42 156.0 COG0376@1|root,COG0376@2|Bacteria,2GJFP@201174|Actinobacteria,2NEXU@228398|Streptacidiphilus 201174|Actinobacteria P Peroxidase katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase CMS1_k127_3647000_4 1125863.JAFN01000001_gene548 2.431e-70 254.0 COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF987.Gmet_0922 CTP_transf_like,PfkB CMS1_k127_3647000_3 1121430.JMLG01000031_gene1630 1.14e-88 315.0 COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,2609J@186807|Peptococcaceae 186801|Clostridia M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd CMS1_k127_3647000_6 300852.55771488 3.086e-59 226.0 COG0036@1|root,COG0036@2|Bacteria,1WI8K@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM Ribulose-phosphate 3 epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim CMS1_k127_3647000_8 1907.SGLAU_09615 9.477e-22 106.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase pknL GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase CMS1_k127_3647000_2 1121468.AUBR01000005_gene33 2.852e-90 314.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,42EKD@68295|Thermoanaerobacterales 186801|Clostridia J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB CMS1_k127_3647000_5 349124.Hhal_2322 4.232e-66 245.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1WWQE@135613|Chromatiales 135613|Chromatiales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N CMS1_k127_3647000_7 667014.Thein_0248 1.818e-42 162.0 COG0242@1|root,COG0242@2|Bacteria,2GHK8@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase CMS1_k127_3647000_9 573413.Spirs_3238 2.979e-20 94.0 COG1862@1|root,COG1862@2|Bacteria,2J8D6@203691|Spirochaetes 203691|Spirochaetes U Preprotein translocase, YajC subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC CMS1_k127_3647000_0 1313304.CALK_1921 9.96e-106 358.0 COG0343@1|root,COG0343@2|Bacteria 2|Bacteria F queuine tRNA-ribosyltransferase activity tgt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT CMS1_k127_3647000_1 1232410.KI421428_gene1054 6.39e-94 317.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains REC, sigma54 interaction, HTH8 - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_3670725_0 269797.Mbar_A0810 1.503e-121 408.0 COG3291@1|root,COG3391@1|root,arCOG03991@1|root,arCOG02508@2157|Archaea,arCOG02562@2157|Archaea,arCOG03991@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia 224756|Methanomicrobia O PFAM PKD domain containing protein - - - - - - - - - - - - PKD CMS1_k127_3670725_1 391625.PPSIR1_38896 8.935e-79 273.0 COG3263@1|root,COG3263@2|Bacteria 2|Bacteria P cell volume homeostasis cvrA GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006884,GO:0008150,GO:0008324,GO:0008361,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0090066,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - ko:K03316,ko:K11105 - - - - ko00000,ko02000 2.A.36,2.A.36.6 - - CorC_HlyC,Na_H_Exchanger,TrkA_C CMS1_k127_3688391_0 1123288.SOV_3c03880 1.245e-17 98.0 COG2911@1|root,COG2911@2|Bacteria,1TQZZ@1239|Firmicutes,4H2F1@909932|Negativicutes 909932|Negativicutes S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - AsmA_2,TamB CMS1_k127_3689747_0 945713.IALB_2989 2.697e-126 434.0 COG0616@1|root,COG0616@2|Bacteria 2|Bacteria OU serine-type peptidase activity sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 CMS1_k127_3689747_1 1183438.GKIL_3389 3.906e-07 55.0 COG0861@1|root,COG0861@2|Bacteria,1G1PC@1117|Cyanobacteria 1117|Cyanobacteria P Membrane protein, TerC - - - - - - - - - - - - TerC CMS1_k127_3691392_0 1267535.KB906767_gene780 1.505e-40 154.0 COG0231@1|root,COG0231@2|Bacteria,3Y373@57723|Acidobacteria,2JIEA@204432|Acidobacteriia 204432|Acidobacteriia J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase - - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C CMS1_k127_3691392_1 882086.SacxiDRAFT_3892 8.189e-15 81.0 COG0596@1|root,COG0596@2|Bacteria,2IJXZ@201174|Actinobacteria,4E5BT@85010|Pseudonocardiales 201174|Actinobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 CMS1_k127_3719645_1 941449.dsx2_1507 2.017e-52 202.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,42NGT@68525|delta/epsilon subdivisions,2WK3E@28221|Deltaproteobacteria,2MB1P@213115|Desulfovibrionales 28221|Deltaproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - iAF987.Gmet_1875 Ham1p_like CMS1_k127_3719645_0 1089553.Tph_c04140 1.044e-87 300.0 COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,42F6J@68295|Thermoanaerobacterales 186801|Clostridia J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 - - - Ham1p_like,RNase_PH,RNase_PH_C CMS1_k127_3719645_2 1121351.AUAP01000001_gene629 0.0005067 45.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2VQ46@28216|Betaproteobacteria,2KQ89@206351|Neisseriales 206351|Neisseriales M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race CMS1_k127_3728809_0 1382356.JQMP01000001_gene901 1.321e-122 409.0 COG1351@1|root,COG1351@2|Bacteria,2G9ZK@200795|Chloroflexi,27XV1@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - - - - - - - - - - Thy1 CMS1_k127_375501_0 760117.JN27_17805 1.858e-206 664.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,472VG@75682|Oxalobacteraceae 28216|Betaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_375501_1 1267534.KB906755_gene4826 5.148e-60 212.0 COG1181@1|root,COG1181@2|Bacteria,3Y6Z0@57723|Acidobacteria,2JKPX@204432|Acidobacteriia 204432|Acidobacteriia M ATP-grasp domain - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C CMS1_k127_3761613_0 357808.RoseRS_0616 4.163e-59 217.0 COG0006@1|root,COG0006@2|Bacteria,2G5J6@200795|Chloroflexi 200795|Chloroflexi C Metallopeptidase family M24 - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 CMS1_k127_3761613_1 546414.Deide_15080 2.614e-31 138.0 COG1668@1|root,COG1668@2|Bacteria,1WIWF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus CP ABC-type Na efflux pump, permease component natB - - ko:K09696 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko02000 3.A.1.115 - - ABC2_membrane_2,ABC2_membrane_3 CMS1_k127_3761613_2 452637.Oter_1528 1.256e-14 75.0 COG4555@1|root,COG4555@2|Bacteria 2|Bacteria CP ABC transporter natA - 3.6.3.7 ko:K01990,ko:K09697 ko02010,ko02020,map02010,map02020 M00253,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.115 - iYO844.BSU02750 ABC_tran CMS1_k127_3770660_1 1304888.ATWF01000001_gene1486 3.317e-90 308.0 COG0752@1|root,COG0752@2|Bacteria,2GEZ4@200930|Deferribacteres 200930|Deferribacteres J Glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e CMS1_k127_3770660_4 525268.HMPREF0308_0827 4.993e-22 106.0 COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,22K9A@1653|Corynebacteriaceae 201174|Actinobacteria L Involved in DNA repair and RecF pathway recombination recO GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N CMS1_k127_3770660_2 264732.Moth_0597 1.012e-39 156.0 COG2928@1|root,COG2928@2|Bacteria,1V6FM@1239|Firmicutes,24JQ1@186801|Clostridia,42GJH@68295|Thermoanaerobacterales 186801|Clostridia S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 CMS1_k127_3770660_3 404589.Anae109_2711 4.613e-23 107.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,42TCJ@68525|delta/epsilon subdivisions,2X5PW@28221|Deltaproteobacteria,2Z2ZQ@29|Myxococcales 28221|Deltaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 CMS1_k127_3770660_0 370438.PTH_0891 6.946e-103 361.0 COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia,2610I@186807|Peptococcaceae 186801|Clostridia S 7TM receptor with intracellular HD hydrolase - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD CMS1_k127_3796834_27 292459.STH2500 1.239e-18 89.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia 186801|Clostridia E MeTHIonine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans CMS1_k127_3796834_20 1047013.AQSP01000134_gene1339 7.945e-44 167.0 COG5012@1|root,COG5012@2|Bacteria,2NQTJ@2323|unclassified Bacteria 2|Bacteria S B12 binding domain - - - ko:K14084 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124 RC00035,RC00732,RC02984 ko00000,ko00001,ko00002 - - - B12-binding,B12-binding_2 CMS1_k127_3796834_13 1192034.CAP_8404 6.103e-95 330.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process - - 4.2.2.3 ko:K01729 ko00051,map00051 - R03706 - ko00000,ko00001,ko01000 - - - Beta_helix,Chondroitinas_B CMS1_k127_3796834_26 926560.KE387023_gene3760 1.286e-29 137.0 COG2133@1|root,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - CHRD,Malectin CMS1_k127_3796834_7 1379270.AUXF01000003_gene3415 5.245e-129 428.0 COG2273@1|root,COG2273@2|Bacteria 2|Bacteria G xyloglucan:xyloglucosyl transferase activity - - 3.2.1.73 ko:K01216,ko:K07004 - - - - ko00000,ko01000 - - - CBM_6,DUF4971,F5_F8_type_C,Glyco_hydro_16,HemolysinCabind,PA14,Trypsin CMS1_k127_3796834_8 1379270.AUXF01000003_gene3414 4.869e-128 428.0 COG1940@1|root,COG1940@2|Bacteria,1ZV0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes GK ROK family - - - - - - - - - - - - ROK CMS1_k127_3796834_14 1239962.C943_01652 3.355e-91 317.0 COG2273@1|root,COG2273@2|Bacteria,4NHP5@976|Bacteroidetes,47URJ@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolases family 16 - - - - - - - - - - - - Glyco_hydro_16 CMS1_k127_3796834_4 1242864.D187_010459 2.035e-211 679.0 COG0747@1|root,COG0747@2|Bacteria,1N4PK@1224|Proteobacteria,42P0B@68525|delta/epsilon subdivisions,2X5XH@28221|Deltaproteobacteria,2YUKB@29|Myxococcales 28221|Deltaproteobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 CMS1_k127_3796834_6 1144275.COCOR_03970 2.626e-140 452.0 COG0601@1|root,COG0601@2|Bacteria,1NH5E@1224|Proteobacteria,42SMT@68525|delta/epsilon subdivisions,2WPBM@28221|Deltaproteobacteria,2YTSY@29|Myxococcales 28221|Deltaproteobacteria P ABC transporter permease - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS1_k127_3796834_10 391625.PPSIR1_05353 1.279e-103 363.0 COG1173@1|root,COG1173@2|Bacteria,1R4JX@1224|Proteobacteria,42THM@68525|delta/epsilon subdivisions,2X5XI@28221|Deltaproteobacteria,2YU8B@29|Myxococcales 28221|Deltaproteobacteria P ABC transporter permease - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS1_k127_3796834_9 448385.sce4299 3.425e-115 379.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,42M3F@68525|delta/epsilon subdivisions,2X35I@28221|Deltaproteobacteria,2YUD1@29|Myxococcales 28221|Deltaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY CMS1_k127_3796834_0 1379270.AUXF01000003_gene3409 0.0 1251.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.2.1.89 ko:K01224 - - - - ko00000,ko01000 - - - Big_4,F5_F8_type_C,Glyco_hydro_2_C,Glyco_hydro_53 CMS1_k127_3796834_5 483219.LILAB_13735 1.608e-190 611.0 COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,42UR5@68525|delta/epsilon subdivisions,2WQET@28221|Deltaproteobacteria,2YU29@29|Myxococcales 28221|Deltaproteobacteria G Glycosyl hydrolase family 1 - - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1 CMS1_k127_3796834_12 1297742.A176_01633 2.294e-97 330.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,42TDH@68525|delta/epsilon subdivisions,2WIQT@28221|Deltaproteobacteria,2YU0S@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY CMS1_k127_3796834_23 935836.JAEL01000084_gene766 1.082e-37 162.0 COG2273@1|root,COG2273@2|Bacteria,1UA30@1239|Firmicutes,4IKCF@91061|Bacilli,1ZGF5@1386|Bacillus 91061|Bacilli G Hydrolase Family 16 - - - - - - - - - - - - Glyco_hydro_16 CMS1_k127_3796834_28 880073.Calab_3359 2.489e-12 80.0 COG4632@1|root,COG4632@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CW_binding_2,Metallophos,NAGPA,Polysacc_deac_1,SLH CMS1_k127_3796834_18 1129794.C427_1747 2.524e-67 243.0 COG5309@1|root,COG5309@2|Bacteria,1Q5JR@1224|Proteobacteria,1SJJ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Glycosyl hydrolases family 17 - - - - - - - - - - - - Glyco_hydro_17 CMS1_k127_3796834_2 452637.Oter_1265 0.0 1055.0 28HKI@1|root,2Z7VC@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_3796834_25 1537994.JQFW01000027_gene2058 4.451e-33 149.0 COG2273@1|root,COG2273@2|Bacteria,1NFHX@1224|Proteobacteria,1RRPK@1236|Gammaproteobacteria,464WR@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolases family 16 - - - - - - - - - - - - CBM_6,Glyco_hydro_16 CMS1_k127_3796834_29 1089550.ATTH01000001_gene1901 1.006e-08 69.0 COG4447@1|root,COG4447@2|Bacteria,4P02B@976|Bacteroidetes,1FIYU@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S FlgD Ig-like domain - - - - - - - - - - - - FlgD_ig CMS1_k127_3796834_21 1537994.JQFW01000027_gene2058 8.83e-39 158.0 COG2273@1|root,COG2273@2|Bacteria,1NFHX@1224|Proteobacteria,1RRPK@1236|Gammaproteobacteria,464WR@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolases family 16 - - - - - - - - - - - - CBM_6,Glyco_hydro_16 CMS1_k127_3796834_30 459349.CLOAM0984 1.194e-08 66.0 COG1361@1|root,COG1361@2|Bacteria,2NS3P@2323|unclassified Bacteria 2|Bacteria M Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - CHU_C,FlgD_ig,Peptidase_C25,Peptidase_C25_C,Propeptide_C25 CMS1_k127_3796834_11 1267533.KB906738_gene2164 3.738e-103 344.0 COG0258@1|root,COG0258@2|Bacteria,3Y2FG@57723|Acidobacteria,2JME1@204432|Acidobacteriia 204432|Acidobacteriia L Helix-hairpin-helix class 2 (Pol1 family) motifs - - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N CMS1_k127_3796834_24 1122939.ATUD01000005_gene2799 4.15e-34 135.0 COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4CT9K@84995|Rubrobacteria 84995|Rubrobacteria S Uncharacterized conserved protein (DUF2277) - - - - - - - - - - - - DUF2277 CMS1_k127_3796834_22 118173.KB235914_gene1053 1.585e-38 151.0 COG2947@1|root,COG2947@2|Bacteria,1G63D@1117|Cyanobacteria,1HHB6@1150|Oscillatoriales 1117|Cyanobacteria S EVE domain - - - - - - - - - - - - EVE CMS1_k127_3796834_1 196490.AUEZ01000058_gene1085 0.0 1145.0 COG0507@1|root,COG1112@1|root,COG2251@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,2TTSD@28211|Alphaproteobacteria,3JQNN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L AAA domain - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,RNase_H_2 CMS1_k127_3796834_15 316067.Geob_1840 8.656e-85 297.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,43BI9@68525|delta/epsilon subdivisions,2X6WN@28221|Deltaproteobacteria,43U6T@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 CMS1_k127_3796834_17 1297865.APJD01000015_gene3469 8.668e-68 239.0 COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,3JSHJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S hydrolase of the alpha beta-hydrolase fold - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_6,DLH,Thioesterase CMS1_k127_3796834_3 404589.Anae109_0939 2.269e-247 794.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales 28221|Deltaproteobacteria L ATP dependent DNA ligase domain protein - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N CMS1_k127_3796834_16 404589.Anae109_0938 1.063e-76 267.0 COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YWME@29|Myxococcales 28221|Deltaproteobacteria L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku CMS1_k127_3796834_19 404589.Anae109_0937 1.311e-53 203.0 COG0457@1|root,COG0457@2|Bacteria,1N4HS@1224|Proteobacteria,43753@68525|delta/epsilon subdivisions,2X219@28221|Deltaproteobacteria,2Z10F@29|Myxococcales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11 CMS1_k127_3799685_2 1150626.PHAMO_320002 0.0007487 45.0 COG0690@1|root,COG0690@2|Bacteria,1N75P@1224|Proteobacteria,2UF51@28211|Alphaproteobacteria,2JTWP@204441|Rhodospirillales 204441|Rhodospirillales U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE CMS1_k127_3799685_0 1379270.AUXF01000007_gene994 4.153e-10 63.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3802224_0 459349.CLOAM0442 9.919e-20 103.0 COG1361@1|root,COG4412@1|root,COG1361@2|Bacteria,COG4412@2|Bacteria,2NRBU@2323|unclassified Bacteria 2|Bacteria M Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - CHU_C,Cleaved_Adhesin,DUF4968,DUF5110,F5_F8_type_C,FlgD_ig,Glyco_hydro_31,Peptidase_C25,Peptidase_C25_C,Propeptide_C25,W_rich_C,fn3 CMS1_k127_3802224_2 73044.JNXP01000020_gene3669 0.0004557 52.0 COG1670@1|root,COG1670@2|Bacteria,2IJAD@201174|Actinobacteria 201174|Actinobacteria J Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 CMS1_k127_3802224_1 671143.DAMO_1115 9.545e-09 59.0 COG0745@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2NQ9F@2323|unclassified Bacteria 2|Bacteria T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg CMS1_k127_3803777_3 1379698.RBG1_1C00001G1295 6.244e-29 125.0 COG3175@1|root,COG3175@2|Bacteria 2|Bacteria O copper ion binding ctaG GO:0008150,GO:0008535,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 CMS1_k127_3803777_1 1379698.RBG1_1C00001G1296 9.599e-91 307.0 COG0109@1|root,COG0109@2|Bacteria,2NPBW@2323|unclassified Bacteria 2|Bacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA CMS1_k127_3803777_2 1379698.RBG1_1C00001G1297 3.741e-31 137.0 COG1612@1|root,COG1612@2|Bacteria,2NQ3D@2323|unclassified Bacteria 2|Bacteria O Cytochrome oxidase assembly protein ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA CMS1_k127_3803777_0 1379698.RBG1_1C00001G1298 6.245e-186 589.0 COG0843@1|root,COG0843@2|Bacteria,2NNTQ@2323|unclassified Bacteria 2|Bacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B cyoB GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009486,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015453,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016679,GO:0016682,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0020037,GO:0022804,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0040007,GO:0042773,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902494,GO:1902600 1.10.3.10,1.10.3.12,1.9.3.1 ko:K02274,ko:K02298,ko:K02827,ko:K15408 ko00190,ko01100,map00190,map01100 M00155,M00416,M00417 R00081,R09492,R11335 RC00016,RC00061,RC00819 ko00000,ko00001,ko00002,ko01000 3.D.4.1,3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6 - - COX1 CMS1_k127_3811947_4 237368.SCABRO_03960 5.257e-61 218.0 COG0705@1|root,COG0705@2|Bacteria,2IZZY@203682|Planctomycetes 203682|Planctomycetes S PFAM Rhomboid family - - - - - - - - - - - - Rhomboid CMS1_k127_3811947_3 1120919.AUBI01000003_gene1476 3.197e-65 238.0 COG1680@1|root,COG1680@2|Bacteria,1QUYZ@1224|Proteobacteria,2VF2D@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_3811947_1 1121091.AUMP01000037_gene2934 8.624e-203 640.0 COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes,4HBBD@91061|Bacilli 91061|Bacilli C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL CMS1_k127_3811947_0 448385.sce8725 4.94e-231 727.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,42P3R@68525|delta/epsilon subdivisions,2X349@28221|Deltaproteobacteria,2YU6W@29|Myxococcales 28221|Deltaproteobacteria H Malate synthase aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Hemerythrin,ICL,Malate_synthase CMS1_k127_3811947_2 1121920.AUAU01000017_gene1241 1.739e-119 398.0 COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria 2|Bacteria K sequence-specific DNA binding MA20_44725 - - ko:K07110,ko:K22300 - - - - ko00000,ko03000 - - - DUF2083,HTH_19,HTH_3,HTH_31,Peptidase_M78 CMS1_k127_3816692_0 225849.swp_1306 2.229e-56 199.0 COG0251@1|root,COG0251@2|Bacteria,1MXIU@1224|Proteobacteria,1SAUW@1236|Gammaproteobacteria,2QE1X@267890|Shewanellaceae 1236|Gammaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Aldo_ket_red,Ribonuc_L-PSP CMS1_k127_3816692_1 697282.Mettu_0279 1.604e-28 125.0 29IJ4@1|root,313M6@2|Bacteria,1R385@1224|Proteobacteria,1ST0Z@1236|Gammaproteobacteria,1XG5A@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF1579) - - - - - - - - - - - - DUF1579 CMS1_k127_3816692_2 1496688.ER33_11555 1.387e-20 91.0 COG3408@1|root,COG3408@2|Bacteria,1G2AS@1117|Cyanobacteria,22THV@167375|Cyanobium 1117|Cyanobacteria G Amylo-alpha-1,6-glucosidase - - - - - - - - - - - - GDE_C,GDE_N CMS1_k127_3829017_1 1157490.EL26_09005 4.848e-171 548.0 COG3508@1|root,COG3508@2|Bacteria,1UYZ0@1239|Firmicutes,4HCCC@91061|Bacilli,2785R@186823|Alicyclobacillaceae 91061|Bacilli Q homogentisate 1,2-dioxygenase - - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA CMS1_k127_3829017_2 1329516.JPST01000066_gene1840 1.442e-80 295.0 COG0179@1|root,COG0179@2|Bacteria,1UY98@1239|Firmicutes,4HC89@91061|Bacilli,27BC2@186824|Thermoactinomycetaceae 91061|Bacilli Q Fumarylacetoacetate (FAA) hydrolase family - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase CMS1_k127_3829017_0 240015.ACP_3311 1.149e-171 546.0 COG3185@1|root,COG3185@2|Bacteria,3Y2ST@57723|Acidobacteria,2JISR@204432|Acidobacteriia 204432|Acidobacteriia E Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal - - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase CMS1_k127_3838033_1 1437824.BN940_12481 1.074e-96 335.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,3T22V@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 CMS1_k127_3838033_0 710111.FraQA3DRAFT_5657 1.009e-116 405.0 COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,4ES1B@85013|Frankiales 201174|Actinobacteria E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_3865151_0 314230.DSM3645_22244 3.56e-74 265.0 COG0492@1|root,COG0492@2|Bacteria,2IXDP@203682|Planctomycetes 203682|Planctomycetes O Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 CMS1_k127_3865151_5 215803.DB30_0636 7.048e-24 115.0 COG0457@1|root,COG0457@2|Bacteria,1QX47@1224|Proteobacteria,42Y0X@68525|delta/epsilon subdivisions,2WT7V@28221|Deltaproteobacteria,2YW72@29|Myxococcales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,Zincin_1 CMS1_k127_3865151_1 1379698.RBG1_1C00001G1293 1.907e-67 238.0 COG1845@1|root,COG1845@2|Bacteria,2NPIG@2323|unclassified Bacteria 2|Bacteria C cytochrome c oxidase subunit III ctaE GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - iJN678.ctaE COX3 CMS1_k127_3865151_3 1121920.AUAU01000006_gene301 7.643e-43 171.0 2BYAB@1|root,32R2Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_3865151_4 1379270.AUXF01000002_gene1204 2.834e-37 143.0 COG1733@1|root,COG1733@2|Bacteria,1ZV9F@142182|Gemmatimonadetes 142182|Gemmatimonadetes K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR CMS1_k127_3865151_2 1519464.HY22_13125 1.694e-48 189.0 COG0737@1|root,COG1520@1|root,COG0737@2|Bacteria,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - 3.4.17.18 ko:K05996 - - - - ko00000,ko01000,ko01002 - - - 5_nucleotid_C,Cytochrome_C554,SBP_bac_8,SLH CMS1_k127_3883421_1 292459.STH2398 5.554e-58 211.0 COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_9,Response_reg CMS1_k127_3883421_0 383381.EH30_15300 1.237e-112 371.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,2TTGZ@28211|Alphaproteobacteria,2K0V2@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 CMS1_k127_3908775_4 1463936.JOJI01000001_gene1997 1.54e-29 129.0 COG0500@1|root,COG0500@2|Bacteria,2I2Y4@201174|Actinobacteria 201174|Actinobacteria Q o-methyltransferase - - 2.1.1.302 ko:K21377 - - - - ko00000,ko01000 - - - Dimerisation2,Methyltransf_2 CMS1_k127_3908775_1 378806.STAUR_2291 1.948e-112 380.0 COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,42UJZ@68525|delta/epsilon subdivisions,2WQCC@28221|Deltaproteobacteria,2YV77@29|Myxococcales 28221|Deltaproteobacteria F adenosine deaminase add - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase CMS1_k127_3908775_2 1379270.AUXF01000006_gene235 9.398e-104 359.0 COG0243@1|root,COG1034@1|root,COG0243@2|Bacteria,COG1034@2|Bacteria,1ZTDW@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3 CMS1_k127_3908775_0 936136.ARRT01000006_gene5766 1.873e-159 512.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2U2JT@28211|Alphaproteobacteria,4BB5D@82115|Rhizobiaceae 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF2 - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB CMS1_k127_3908775_3 204669.Acid345_1313 2.29e-32 127.0 COG0649@1|root,COG0649@2|Bacteria,3Y3N1@57723|Acidobacteria,2JIDU@204432|Acidobacteriia 204432|Acidobacteriia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa,NiFeSe_Hases CMS1_k127_3911584_0 1121918.ARWE01000001_gene3080 8.703e-127 413.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,43TT3@69541|Desulfuromonadales 68525|delta/epsilon subdivisions C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N CMS1_k127_3911584_1 1121918.ARWE01000001_gene3081 2.948e-115 395.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,43V7G@69541|Desulfuromonadales 28221|Deltaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1,1.2.7.7 ko:K00170,ko:K00187 ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R07160,R08034,R08566,R08567 RC00004,RC00250,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C CMS1_k127_3911584_3 234267.Acid_4208 2.141e-39 154.0 COG1913@1|root,COG1913@2|Bacteria,3Y880@57723|Acidobacteria 57723|Acidobacteria S Peptidase family M54 - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 CMS1_k127_3911584_2 945713.IALB_2429 8.868e-62 218.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02481,ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_3917218_1 1232410.KI421424_gene1794 1.019e-132 437.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria,43TSP@69541|Desulfuromonadales 28221|Deltaproteobacteria C Proton-conducting membrane transporter nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M CMS1_k127_3917218_0 247490.KSU1_D0316 7.713e-189 610.0 COG1008@1|root,COG1008@2|Bacteria,2IX79@203682|Planctomycetes 203682|Planctomycetes C proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M CMS1_k127_3917218_2 945713.IALB_1869 7.466e-20 91.0 COG1009@1|root,COG1009@2|Bacteria 2|Bacteria CP NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N CMS1_k127_3926685_2 1242864.D187_007788 2.612e-27 125.0 COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,42UQI@68525|delta/epsilon subdivisions,2WQII@28221|Deltaproteobacteria,2YVBZ@29|Myxococcales 28221|Deltaproteobacteria S Glyoxalase-like domain - - - ko:K07032 - - - - ko00000 - - - Glyoxalase CMS1_k127_3926685_4 1121946.AUAX01000039_gene5751 8.001e-17 96.0 COG3227@1|root,COG3227@2|Bacteria,2GN0P@201174|Actinobacteria,4D9AK@85008|Micromonosporales 201174|Actinobacteria E Fungalysin metallopeptidase (M36) - - - - - - - - - - - - FTP,Peptidase_M36 CMS1_k127_3926685_5 574375.BAGA_18520 0.0001766 55.0 COG3227@1|root,COG3227@2|Bacteria,1TSGU@1239|Firmicutes,4HC7W@91061|Bacilli 91061|Bacilli E Peptidase M36 - - - - - - - - - - - - FTP,PepSY,Peptidase_M36 CMS1_k127_3926685_1 926569.ANT_12300 1.41e-40 156.0 COG3293@1|root,COG3293@2|Bacteria,2G9EK@200795|Chloroflexi 200795|Chloroflexi L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF4096 CMS1_k127_3926685_0 498211.CJA_0333 6.971e-41 156.0 COG3293@1|root,COG3293@2|Bacteria,1N5YJ@1224|Proteobacteria,1S5EG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DUF4096 CMS1_k127_3926685_3 215803.DB30_6391 4.636e-27 112.0 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2YUH5@29|Myxococcales 28221|Deltaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short CMS1_k127_3955322_8 1379698.RBG1_1C00001G0107 3.024e-24 106.0 COG3170@1|root,COG3170@2|Bacteria,2NPXD@2323|unclassified Bacteria 2|Bacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - CMS1_k127_3955322_3 234267.Acid_0826 6.328e-87 298.0 COG0803@1|root,COG0803@2|Bacteria,3Y97A@57723|Acidobacteria 57723|Acidobacteria P Zinc-uptake complex component A periplasmic - - - ko:K02077 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ZnuA CMS1_k127_3955322_6 1379698.RBG1_1C00001G0109 6.793e-76 279.0 COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria 2|Bacteria U ABC 3 transport family znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 CMS1_k127_3955322_5 1484460.JSWG01000015_gene870 1.036e-78 297.0 COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,1I4B1@117743|Flavobacteriia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 CMS1_k127_3955322_2 404589.Anae109_4239 5.797e-135 447.0 COG0654@1|root,COG0654@2|Bacteria,1R03K@1224|Proteobacteria,43CQQ@68525|delta/epsilon subdivisions,2X7Y6@28221|Deltaproteobacteria,2Z1K0@29|Myxococcales 28221|Deltaproteobacteria CH FAD binding domain - - - - - - - - - - - - FAD_binding_3 CMS1_k127_3955322_1 404589.Anae109_4240 2.305e-163 537.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,437TD@68525|delta/epsilon subdivisions,2WT6I@28221|Deltaproteobacteria,2YX1E@29|Myxococcales 28221|Deltaproteobacteria C L-lysine 6-monooxygenase (NADPH-requiring) - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 CMS1_k127_3955322_4 404589.Anae109_4241 4.635e-84 284.0 COG1765@1|root,COG1765@2|Bacteria,1RBJN@1224|Proteobacteria,43AKT@68525|delta/epsilon subdivisions,2X60V@28221|Deltaproteobacteria,2Z23B@29|Myxococcales 28221|Deltaproteobacteria O OsmC-like protein - - - - - - - - - - - - OsmC CMS1_k127_3955322_0 237368.SCABRO_03725 8.336e-181 578.0 COG1697@1|root,COG1697@2|Bacteria,2J34C@203682|Planctomycetes 203682|Planctomycetes L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6A - 5.99.1.3 ko:K03166 - - - - ko00000,ko01000,ko03032 - - - TP6A_N CMS1_k127_3955322_7 622637.KE124770_gene148 2.182e-44 164.0 COG1389@1|root,COG1389@2|Bacteria,1R6T0@1224|Proteobacteria 1224|Proteobacteria L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,HATPase_c_3,Topo-VIb_trans CMS1_k127_3955957_2 459349.CLOAM1149 8.837e-13 79.0 COG1747@1|root,COG3064@1|root,COG1747@2|Bacteria,COG3064@2|Bacteria,2NP33@2323|unclassified Bacteria 2|Bacteria M methyltransferase greA - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - GreA_GreB,GreA_GreB_N,SprA_N CMS1_k127_3955957_0 1379698.RBG1_1C00001G0436 2.764e-69 246.0 COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria 2|Bacteria S Peptidase M28 ywaD - - - - - - - - - - - Peptidase_M28 CMS1_k127_3955957_1 1125863.JAFN01000001_gene1427 9.844e-29 122.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,42THF@68525|delta/epsilon subdivisions,2WQ0W@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C CMS1_k127_3980005_2 1035191.HMPREF0185_02486 8.536e-92 306.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2KEYS@204458|Caulobacterales 204458|Caulobacterales O peptidase M13 - - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N CMS1_k127_3980005_4 886293.Sinac_1029 2.77e-55 203.0 COG0631@1|root,COG0631@2|Bacteria,2IZVG@203682|Planctomycetes 203682|Planctomycetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS1_k127_3980005_6 1198452.Jab_2c23300 1.521e-21 102.0 2E902@1|root,3339H@2|Bacteria,1N9U6@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_3980005_1 290397.Adeh_2107 2.778e-97 329.0 COG0500@1|root,COG2226@2|Bacteria,1R98E@1224|Proteobacteria,43847@68525|delta/epsilon subdivisions,2X3E4@28221|Deltaproteobacteria,2YVN5@29|Myxococcales 28221|Deltaproteobacteria Q Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 CMS1_k127_3980005_5 204669.Acid345_0949 6.365e-33 133.0 2EBAA@1|root,335AW@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - RsbRD_N CMS1_k127_3980005_0 684949.ATTJ01000001_gene1258 9.73e-106 351.0 COG0778@1|root,COG0778@2|Bacteria 2|Bacteria C coenzyme F420-1:gamma-L-glutamate ligase activity - - 1.5.1.38,1.5.1.39 ko:K19285,ko:K19286 ko00740,ko01100,map00740,map01100 - R05705,R05706 RC00126 ko00000,ko00001,ko01000 - - - Nitroreductase CMS1_k127_3980005_7 1379698.RBG1_1C00001G0632 1e-10 70.0 COG1366@1|root,COG1366@2|Bacteria,2NRCS@2323|unclassified Bacteria 2|Bacteria T STAS domain rsbV - - ko:K04749 - - - - ko00000,ko03021 - - - STAS,STAS_2 CMS1_k127_3980005_3 530564.Psta_2518 1.521e-75 258.0 COG0189@1|root,COG0189@2|Bacteria 2|Bacteria HJ Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) dcsG - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,RimK CMS1_k127_3987585_0 1379698.RBG1_1C00001G0435 3.871e-161 568.0 COG1747@1|root,COG1747@2|Bacteria,2NP33@2323|unclassified Bacteria 2|Bacteria M methyltransferase greA - - - - - - - - - - - GreA_GreB,GreA_GreB_N,SprA_N CMS1_k127_3987585_1 1379698.RBG1_1C00001G1858 1.042e-80 292.0 COG0795@1|root,COG0795@2|Bacteria,2NP9S@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ family protein lptF GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K07091,ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - iECED1_1282.ECED1_5114,iUMNK88_1353.UMNK88_5207 YjgP_YjgQ CMS1_k127_3987585_2 671143.DAMO_0314 6.541e-28 132.0 COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ CMS1_k127_3990550_0 237368.SCABRO_03724 8.33e-175 559.0 COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes 203682|Planctomycetes L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans CMS1_k127_4006041_1 944481.JAFP01000001_gene699 2.116e-24 110.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2M6BE@213113|Desulfurellales 28221|Deltaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC CMS1_k127_4006041_0 1379698.RBG1_1C00001G0197 1.304e-61 222.0 COG1521@1|root,COG1521@2|Bacteria,2NP3Z@2323|unclassified Bacteria 2|Bacteria K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1986 Pan_kinase CMS1_k127_4006041_2 469382.Hbor_26520 0.0009606 50.0 arCOG10178@1|root,arCOG10178@2157|Archaea,2XY0I@28890|Euryarchaeota,23WIX@183963|Halobacteria 183963|Halobacteria S CAAX protease self-immunity - - - - - - - - - - - - Abi CMS1_k127_4035297_0 1379698.RBG1_1C00001G1488 3.734e-99 340.0 COG0484@1|root,COG0484@2|Bacteria,2NNNG@2323|unclassified Bacteria 2|Bacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG CMS1_k127_4035297_1 1504981.KO116_3972 2.382e-28 124.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1XK1E@135619|Oceanospirillales 135619|Oceanospirillales O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE CMS1_k127_4035297_2 525903.Taci_0620 0.0002427 46.0 COG1420@1|root,COG1420@2|Bacteria,3TA2U@508458|Synergistetes 508458|Synergistetes K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg CMS1_k127_4077231_0 1279009.ADICEAN_02248 9.236e-175 558.0 COG1629@1|root,COG4771@2|Bacteria,4NFJJ@976|Bacteroidetes,47MJ2@768503|Cytophagia 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS1_k127_4078412_1 221288.JH992901_gene1645 1.489e-43 179.0 COG1409@1|root,COG1409@2|Bacteria,1GBWV@1117|Cyanobacteria,1JJX6@1189|Stigonemataceae 1117|Cyanobacteria S Purple acid Phosphatase, N-terminal domain - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N CMS1_k127_4078412_3 518766.Rmar_1071 2.901e-07 63.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase CMS1_k127_4078412_0 861299.J421_4169 1.013e-75 288.0 COG0531@1|root,COG0531@2|Bacteria,1ZSQW@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS1_k127_4078412_2 794903.OPIT5_07475 8.517e-16 81.0 2C130@1|root,30TQV@2|Bacteria,46XGK@74201|Verrucomicrobia,3K9V7@414999|Opitutae 414999|Opitutae S Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg CMS1_k127_4080765_1 518766.Rmar_2362 6.033e-63 224.0 COG1215@1|root,COG1215@2|Bacteria,4NH18@976|Bacteroidetes,1FJVU@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Glycosyl transferase family 21 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,Sulfatase CMS1_k127_4080765_0 1193181.BN10_50002 2.449e-68 262.0 COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria 201174|Actinobacteria M PFAM peptidase M6, immune inhibitor A - - - - - - - - - - - - Peptidase_M6 CMS1_k127_4080765_2 459349.CLOAM0442 4.802e-14 87.0 COG1361@1|root,COG4412@1|root,COG1361@2|Bacteria,COG4412@2|Bacteria,2NRBU@2323|unclassified Bacteria 2|Bacteria M Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - CHU_C,Cleaved_Adhesin,DUF4968,DUF5110,F5_F8_type_C,FlgD_ig,Glyco_hydro_31,Peptidase_C25,Peptidase_C25_C,Propeptide_C25,W_rich_C,fn3 CMS1_k127_4089004_1 396588.Tgr7_0275 1.044e-57 213.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales 135613|Chromatiales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII CMS1_k127_4089004_2 926561.KB900617_gene1496 1.54e-40 154.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,3WAJ5@53433|Halanaerobiales 186801|Clostridia K PFAM response regulator receiver phoP - - ko:K02483,ko:K07658,ko:K07668 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C CMS1_k127_4089004_0 269799.Gmet_1991 1.095e-65 237.0 COG0642@1|root,COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2206@2|Bacteria,1NSAV@1224|Proteobacteria,42Z68@68525|delta/epsilon subdivisions,2WURV@28221|Deltaproteobacteria,43U68@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains GAF, HisKA, HATPase_c, GAF, HD-GYP-related - - - - - - - - - - - - GAF_2,HD_5,HisKA CMS1_k127_4104207_11 404589.Anae109_3257 4.651e-08 57.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RAB@68525|delta/epsilon subdivisions,2X5MA@28221|Deltaproteobacteria,2Z369@29|Myxococcales 28221|Deltaproteobacteria L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp CMS1_k127_4104207_4 404589.Anae109_2673 2.845e-53 193.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - Cytochrome_C554,DUF11,SLH CMS1_k127_4104207_1 290397.Adeh_2681 2.549e-90 303.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,42RJR@68525|delta/epsilon subdivisions,2WMK3@28221|Deltaproteobacteria,2YVG8@29|Myxococcales 28221|Deltaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 CMS1_k127_4104207_5 290397.Adeh_2677 1.254e-40 153.0 COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,42SDH@68525|delta/epsilon subdivisions,2WPPH@28221|Deltaproteobacteria,2Z333@29|Myxococcales 28221|Deltaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length greB - - ko:K04760 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N CMS1_k127_4104207_2 1131814.JAFO01000001_gene2857 2.723e-69 251.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,3EYR5@335928|Xanthobacteraceae 28211|Alphaproteobacteria EH Anthranilate synthase component I, N terminal region pabB - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind CMS1_k127_4104207_0 398512.JQKC01000001_gene2443 1.018e-165 529.0 COG1932@1|root,COG1932@2|Bacteria,1UHH6@1239|Firmicutes,25Q8I@186801|Clostridia,3WI3X@541000|Ruminococcaceae 186801|Clostridia EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine - - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 CMS1_k127_4104207_8 555088.DealDRAFT_2591 1.262e-18 99.0 COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,42K53@68298|Syntrophomonadaceae 186801|Clostridia E Prephenate dehydratase pheA - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDT CMS1_k127_4104207_9 404589.Anae109_2686 7.484e-18 96.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,2YTVG@29|Myxococcales 28221|Deltaproteobacteria E acetylornithine aminotransferase argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iAF987.Gmet_0204 Aminotran_3 CMS1_k127_4104207_10 290397.Adeh_4227 1.291e-14 75.0 COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,42SPV@68525|delta/epsilon subdivisions,2WPTH@28221|Deltaproteobacteria,2Z0HM@29|Myxococcales 28221|Deltaproteobacteria P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div CMS1_k127_4105992_2 243231.GSU2730 2.763e-18 93.0 2ED7H@1|root,33743@2|Bacteria,1QB7X@1224|Proteobacteria,42ZXA@68525|delta/epsilon subdivisions,2WVEQ@28221|Deltaproteobacteria,43V94@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_4105992_1 1123228.AUIH01000043_gene1788 1.566e-30 128.0 COG3874@1|root,COG3874@2|Bacteria,1N4RT@1224|Proteobacteria,1SQI8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sporulation protein YtfJ (Spore_YtfJ) - - - - - - - - - - - - Spore_YtfJ CMS1_k127_4105992_4 1255043.TVNIR_3689 3.655e-08 62.0 2E21G@1|root,32X98@2|Bacteria,1N21H@1224|Proteobacteria,1SSTY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2953) - - - - - - - - - - - - DUF2953 CMS1_k127_4105992_0 298386.PBPRA1243 1.705e-52 206.0 COG3187@1|root,COG3895@1|root,COG4461@1|root,COG3187@2|Bacteria,COG3895@2|Bacteria,COG4461@2|Bacteria,1PF0Q@1224|Proteobacteria,1TBDV@1236|Gammaproteobacteria,1XWBZ@135623|Vibrionales 135623|Vibrionales O META domain - - - - - - - - - - - - META CMS1_k127_4105992_3 1313265.JNIE01000007_gene43 2.868e-16 93.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - - - - - - - - - - Lactamase_B CMS1_k127_4131280_4 1191523.MROS_2800 2.856e-25 105.0 COG0334@1|root,COG0334@2|Bacteria 2|Bacteria E glutamate dehydrogenase [NAD(P)+] activity gluD GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.gdhA ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_4131280_1 1499967.BAYZ01000119_gene3216 2.282e-192 617.0 COG0574@1|root,COG0574@2|Bacteria,2NQHP@2323|unclassified Bacteria 2|Bacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_2,PPDK_N,Response_reg CMS1_k127_4131280_0 1191523.MROS_2798 0.0 1163.0 COG0574@1|root,COG0574@2|Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_2,PPDK_N,Response_reg CMS1_k127_4131280_2 1499967.BAYZ01000119_gene3214 1.077e-104 347.0 COG2129@1|root,COG2129@2|Bacteria 2|Bacteria L metallophosphoesterase - - - ko:K07096 - - - - ko00000 - - - Metallophos,Metallophos_2,Metallophos_3 CMS1_k127_4131280_3 357808.RoseRS_3279 1.307e-62 225.0 COG1277@1|root,COG1277@2|Bacteria,2G79P@200795|Chloroflexi 200795|Chloroflexi S ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_2 CMS1_k127_4141699_3 1144319.PMI16_00682 3.207e-07 62.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,4730Z@75682|Oxalobacteraceae 28216|Betaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri,YfiO CMS1_k127_4141699_1 290317.Cpha266_0860 3.424e-39 160.0 COG2885@1|root,COG2885@2|Bacteria,1FEC5@1090|Chlorobi 1090|Chlorobi M PFAM OmpA MotB domain protein - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA CMS1_k127_4141699_0 671143.DAMO_0497 1.146e-88 310.0 COG0823@1|root,COG0823@2|Bacteria,2NNZC@2323|unclassified Bacteria 2|Bacteria U TolB amino-terminal domain tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N CMS1_k127_4141699_2 1379698.RBG1_1C00001G0499 3.824e-18 91.0 COG0810@1|root,COG0810@2|Bacteria,2NQ3G@2323|unclassified Bacteria 2|Bacteria M TonB C terminal - - - ko:K03646,ko:K03832 - - - - ko00000,ko02000 2.C.1.1,2.C.1.2 - - CarbopepD_reg_2,TonB_2,TonB_C CMS1_k127_4155569_0 1379698.RBG1_1C00001G1060 5.886e-195 617.0 COG1009@1|root,COG1009@2|Bacteria,2NNU6@2323|unclassified Bacteria 2|Bacteria CP NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N CMS1_k127_4155569_5 671143.DAMO_2693 1.96e-29 128.0 COG0713@1|root,COG0713@2|Bacteria,2NPU2@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 CMS1_k127_4155569_6 237368.SCABRO_02001 4.497e-28 119.0 COG0839@1|root,COG0839@2|Bacteria,2J0MC@203682|Planctomycetes 203682|Planctomycetes C PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 CMS1_k127_4155569_1 671143.DAMO_2695 8.038e-122 398.0 COG1005@1|root,COG1005@2|Bacteria,2NNTT@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh CMS1_k127_4155569_2 1382306.JNIM01000001_gene3468 2.678e-41 156.0 COG1905@1|root,COG1905@2|Bacteria,2G70Y@200795|Chloroflexi 200795|Chloroflexi C PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx CMS1_k127_4155569_3 1379698.RBG1_1C00001G1052 6.159e-38 151.0 COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3353 Complex1_30kDa CMS1_k127_4155569_4 404380.Gbem_3926 2.542e-37 145.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42W9X@68525|delta/epsilon subdivisions,2WSEM@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA-1 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 CMS1_k127_4156984_1 349161.Dred_2549 4.313e-36 143.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,25ZZS@186807|Peptococcaceae 186801|Clostridia E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC CMS1_k127_4156984_2 765911.Thivi_0634 5.132e-26 126.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1WWAA@135613|Chromatiales 135613|Chromatiales O peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 CMS1_k127_4156984_0 573370.DMR_19630 3.503e-50 184.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_4178897_2 671143.DAMO_2778 1.917e-46 171.0 COG1209@1|root,COG1209@2|Bacteria,2NNTJ@2323|unclassified Bacteria 2|Bacteria M Nucleotidyl transferase rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase CMS1_k127_4178897_0 760568.Desku_0718 1.698e-64 232.0 COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,261FK@186807|Peptococcaceae 186801|Clostridia M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind CMS1_k127_4178897_3 1262914.BN533_01184 5.384e-45 179.0 COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,4H443@909932|Negativicutes 909932|Negativicutes G SIS domain gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 CMS1_k127_4178897_1 1089553.Tph_c02040 3.5e-62 235.0 COG0382@1|root,COG0382@2|Bacteria,1TRTB@1239|Firmicutes,24AQ0@186801|Clostridia,42G1D@68295|Thermoanaerobacterales 186801|Clostridia H UbiA prenyltransferase family ubiA - - - - - - - - - - - UbiA CMS1_k127_4204121_12 1313294.BPA_0131000 6.021e-05 50.0 COG1316@1|root,COG1316@2|Bacteria,2J57I@203691|Spirochaetes 203691|Spirochaetes K PFAM Cell envelope-related transcriptional attenuator domain - - - - - - - - - - - - LytR_C,LytR_cpsA_psr CMS1_k127_4204121_9 272844.PAB2301 4.202e-42 173.0 COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242M1@183968|Thermococci 183968|Thermococci F Hit family - - 2.7.7.53 ko:K19710 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - HIT CMS1_k127_4204121_5 1458462.JNLK01000001_gene1548 1.824e-58 226.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,27JTA@186928|unclassified Lachnospiraceae 186801|Clostridia M 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase CMS1_k127_4204121_3 330214.NIDE0501 4.505e-70 259.0 COG0414@1|root,COG0414@2|Bacteria,3J0KR@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase CMS1_k127_4204121_2 1267534.KB906758_gene2264 1.902e-91 312.0 COG0413@1|root,COG0413@2|Bacteria,3Y3GX@57723|Acidobacteria,2JI6Y@204432|Acidobacteriia 204432|Acidobacteriia H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf CMS1_k127_4204121_4 671143.DAMO_2311 9.21e-68 237.0 COG1428@1|root,COG1428@2|Bacteria,2NPEH@2323|unclassified Bacteria 2|Bacteria F Deoxynucleoside kinase dgk - 2.7.1.113 ko:K15518 ko00230,map00230 - R01967 RC00002,RC00017 ko00000,ko00001,ko01000 - - - HPPK,dNK CMS1_k127_4204121_7 243274.THEMA_04595 6.037e-44 168.0 COG0801@1|root,COG0801@2|Bacteria,2GDA7@200918|Thermotogae 200918|Thermotogae H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0041 HPPK CMS1_k127_4204121_11 1114972.AUAW01000001_gene1342 3.168e-05 53.0 COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,4HKKK@91061|Bacilli,3F7N6@33958|Lactobacillaceae 91061|Bacilli H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB CMS1_k127_4204121_1 932678.THERU_02265 1.784e-114 381.0 COG0436@1|root,COG0436@2|Bacteria,2G3NP@200783|Aquificae 200783|Aquificae E Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_4204121_6 1379698.RBG1_1C00001G0434 9.299e-54 203.0 COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria 2|Bacteria M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C CMS1_k127_4204121_0 1097668.BYI23_A008190 5.759e-182 578.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,1K1VT@119060|Burkholderiaceae 28216|Betaproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp,Epimerase CMS1_k127_4204121_8 997296.PB1_05807 2.719e-42 159.0 COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,4HA38@91061|Bacilli,1ZBKJ@1386|Bacillus 91061|Bacilli O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0001817,GO:0001819,GO:0001871,GO:0002791,GO:0002793,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009986,GO:0009987,GO:0016465,GO:0030246,GO:0030247,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044764,GO:0046812,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051082,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051704,GO:0061077,GO:0065007,GO:0070201,GO:0090087,GO:0098630,GO:0098743,GO:0101031,GO:1903530,GO:1903532,GO:1904951,GO:1990220,GO:2000482,GO:2000484,GO:2001065 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS1_k127_4206087_0 1089550.ATTH01000001_gene2411 2.115e-89 328.0 COG0358@1|root,COG0358@2|Bacteria,4NENT@976|Bacteroidetes,1FJ4P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 CMS1_k127_4206087_1 292459.STH1115 4.452e-71 256.0 COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia 186801|Clostridia L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr CMS1_k127_4212403_1 1379698.RBG1_1C00001G1235 1.035e-23 117.0 COG1470@1|root,COG1470@2|Bacteria 2|Bacteria S cell adhesion involved in biofilm formation - - - - - - - - - - - - CarbopepD_reg_2 CMS1_k127_4212403_0 1379698.RBG1_1C00001G1236 7.602e-58 209.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - ko:K06882 - - - - ko00000 - - - fn3 CMS1_k127_4221140_3 43759.JNWK01000040_gene2226 7.423e-26 123.0 COG0726@1|root,COG0726@2|Bacteria,2H6C7@201174|Actinobacteria 201174|Actinobacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 CMS1_k127_4221140_2 114615.BRADO0078 4.59e-40 169.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,3JYQC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase CMS1_k127_4221140_1 429009.Adeg_1653 1.754e-102 351.0 COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,42ERN@68295|Thermoanaerobacterales 186801|Clostridia S PFAM peptidase M16 domain protein ymxG - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_4221140_0 1064535.MELS_2026 2.769e-104 347.0 COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,4H38B@909932|Negativicutes 909932|Negativicutes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 CMS1_k127_4255188_1 1379698.RBG1_1C00001G1549 3.752e-95 335.0 COG0777@1|root,COG0777@2|Bacteria,2NP40@2323|unclassified Bacteria 2|Bacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iJN678.accD,iPC815.YPO2768,iUTI89_1310.UTI89_C2601 Carboxyl_trans CMS1_k127_4255188_3 429009.Adeg_0149 1.359e-25 114.0 COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,42G5T@68295|Thermoanaerobacterales 186801|Clostridia K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 CMS1_k127_4255188_4 644966.Tmar_0267 2.882e-13 81.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,3WCP7@538999|Clostridiales incertae sedis 186801|Clostridia O Glycoprotease family yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Acetyltransf_1,Peptidase_M22 CMS1_k127_4255188_2 383372.Rcas_0713 4.901e-26 114.0 COG0802@1|root,COG0802@2|Bacteria,2G6YV@200795|Chloroflexi,375TA@32061|Chloroflexia 32061|Chloroflexia S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE CMS1_k127_4255188_0 1379698.RBG1_1C00001G1545 1.076e-176 567.0 COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria 2|Bacteria KT PglZ domain - - - - - - - - - - - - PglZ,Response_reg CMS1_k127_4262334_0 709986.Deima_2973 3.966e-13 82.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process - - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C CMS1_k127_4268119_1 38833.XP_003064514.1 5.637e-120 396.0 COG0019@1|root,KOG0622@2759|Eukaryota,37Q1G@33090|Viridiplantae,34JJT@3041|Chlorophyta 3041|Chlorophyta E Belongs to the Orn Lys Arg decarboxylase class-II family - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC CMS1_k127_4268119_0 1120797.KB908260_gene4073 1.309e-157 535.0 COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae 201174|Actinobacteria K involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein pknK_2 - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - AAA_22,GerE,NB-ARC,Pkinase,TPR_12 CMS1_k127_4268119_2 880073.Calab_2325 2.184e-13 85.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - - - - - - - - - - Big_2,Laminin_G_3,Metallophos,NAGPA,Pur_ac_phosph_N,SLH,VCBS CMS1_k127_4304211_0 459349.CLOAM1790 9.813e-23 107.0 COG1572@1|root,COG1572@2|Bacteria,2NRE4@2323|unclassified Bacteria 2|Bacteria K Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - CARDB,Cleaved_Adhesin,FlgD_ig,MAM,VCBS CMS1_k127_4304211_1 459349.CLOAM1520 2.122e-16 94.0 COG4412@1|root,COG4412@2|Bacteria,2NQZW@2323|unclassified Bacteria 2|Bacteria S Fibronectin type 3 domain - - - - - - - - - - - - Cleaved_Adhesin,DUF4968,DUF5110,F5_F8_type_C,FlgD_ig,Glyco_hydro_31,W_rich_C,fn3 CMS1_k127_4304211_2 398579.Spea_0135 1.502e-05 55.0 COG3595@1|root,COG3595@2|Bacteria,1RI1P@1224|Proteobacteria,1RRZW@1236|Gammaproteobacteria,2QB2H@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF4097 CMS1_k127_4317960_1 518766.Rmar_2254 1.638e-36 153.0 COG2812@1|root,COG2812@2|Bacteria,4PKEA@976|Bacteroidetes,1FJ1I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 CMS1_k127_4317960_0 1379698.RBG1_1C00001G0315 3.65e-53 208.0 COG4942@1|root,COG4942@2|Bacteria,2NPDY@2323|unclassified Bacteria 2|Bacteria D Peptidase family M23 envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 CMS1_k127_4317960_2 1379270.AUXF01000003_gene3685 2.551e-12 73.0 COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Part of the ABC transporter FtsEX involved in - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - CMS1_k127_4319319_0 269799.Gmet_3127 1.315e-188 633.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,43TI4@69541|Desulfuromonadales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran CMS1_k127_4319319_2 290397.Adeh_3874 3.084e-34 147.0 COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2WKAK@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_4319319_3 243231.GSU0391 6.46e-17 94.0 COG1538@1|root,COG1538@2|Bacteria,1R8XP@1224|Proteobacteria,42QGI@68525|delta/epsilon subdivisions,2X5YV@28221|Deltaproteobacteria,43W2Z@69541|Desulfuromonadales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS1_k127_4319319_1 404589.Anae109_0839 1.534e-49 195.0 COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,43AKN@68525|delta/epsilon subdivisions,2X60M@28221|Deltaproteobacteria,2Z1JH@29|Myxococcales 28221|Deltaproteobacteria K Putative zinc-finger - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2,zf-HC2 CMS1_k127_4345763_2 563192.HMPREF0179_02111 2.281e-05 51.0 COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG2199@2|Bacteria,1RDNA@1224|Proteobacteria,42Q5I@68525|delta/epsilon subdivisions,2WIX0@28221|Deltaproteobacteria,2M8KB@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_7,TPR_8 CMS1_k127_4345763_0 483219.LILAB_17450 1.024e-71 259.0 COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2YU2F@29|Myxococcales 28221|Deltaproteobacteria S ADP-ribosylation factor family mglA GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - ko:K06883 - - - - ko00000 - - - Arf,Ras CMS1_k127_4345763_1 247633.GP2143_11222 3.198e-07 57.0 2CCG0@1|root,2ZVGB@2|Bacteria,1P9KG@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_4353866_2 1125863.JAFN01000001_gene2274 1.198e-43 165.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,42QU1@68525|delta/epsilon subdivisions,2WP6E@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II CMS1_k127_4353866_3 868595.Desca_2117 1.165e-32 139.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,260JY@186807|Peptococcaceae 186801|Clostridia CI Acetyl-CoA carboxylase, biotin carboxyl carrier protein pycB - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA CMS1_k127_4353866_1 1379698.RBG1_1C00001G1502 4.749e-128 419.0 COG2805@1|root,COG2805@2|Bacteria,2NP0T@2323|unclassified Bacteria 2|Bacteria NU Type II/IV secretion system protein pilT-1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS1_k127_4353866_0 760568.Desku_1942 4.216e-141 456.0 COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,26111@186807|Peptococcaceae 186801|Clostridia I TIGRFAM acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS1_k127_4399085_1 335543.Sfum_3449 3.166e-25 109.0 COG2032@1|root,COG2032@2|Bacteria,1N26J@1224|Proteobacteria,43B8H@68525|delta/epsilon subdivisions,2X6MV@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 - - - ko00000,ko00001,ko01000 - - - Sod_Cu CMS1_k127_4399085_0 1379698.RBG1_1C00001G0698 1.017e-206 649.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,2NNV3@2323|unclassified Bacteria 2|Bacteria C Malic enzyme, NAD binding domain maeB GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 ko:K00027,ko:K00029,ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020 M00169,M00172,M00357,M00579 R00214,R00216,R00230,R00921 RC00004,RC00105,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic CMS1_k127_43991_5 445972.ANACOL_03388 4.137e-26 109.0 COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,3WHNZ@541000|Ruminococcaceae 186801|Clostridia L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 CMS1_k127_43991_4 1379270.AUXF01000005_gene389 2.27e-39 154.0 COG2018@1|root,COG2018@2|Bacteria,1ZTK7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Roadblock/LC7 domain - - - - - - - - - - - - Robl_LC7 CMS1_k127_43991_3 483219.LILAB_17450 1.18e-86 289.0 COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2YU2F@29|Myxococcales 28221|Deltaproteobacteria S ADP-ribosylation factor family mglA GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - ko:K06883 - - - - ko00000 - - - Arf,Ras CMS1_k127_43991_7 194439.CT0336 2.052e-22 111.0 COG1267@1|root,COG1267@2|Bacteria,1FE6P@1090|Chlorobi 1090|Chlorobi I PFAM phosphatidylglycerophosphatase A - - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA CMS1_k127_43991_2 768710.DesyoDRAFT_3269 1.883e-87 303.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,2605S@186807|Peptococcaceae 186801|Clostridia S TIGRFAM competence damage-inducible protein CinA cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth CMS1_k127_43991_6 671143.DAMO_2617 4.839e-25 122.0 COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria 2|Bacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase CMS1_k127_43991_0 1267533.KB906733_gene3429 2.07e-151 490.0 COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria,2JHU1@204432|Acidobacteriia 204432|Acidobacteriia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA CMS1_k127_43991_8 552811.Dehly_1344 2.198e-12 74.0 COG2137@1|root,COG2137@2|Bacteria,2G6WA@200795|Chloroflexi,34D0G@301297|Dehalococcoidia 301297|Dehalococcoidia S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX CMS1_k127_43991_1 760568.Desku_2025 2.773e-142 493.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,260FP@186807|Peptococcaceae 186801|Clostridia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS1_k127_4409911_0 1121935.AQXX01000121_gene5574 1.498e-10 74.0 COG0823@1|root,COG5616@1|root,COG0823@2|Bacteria,COG5616@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XITW@135619|Oceanospirillales 135619|Oceanospirillales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N CMS1_k127_4413183_0 1191523.MROS_1718 1.955e-132 432.0 COG0532@1|root,COG0532@2|Bacteria 2|Bacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N CMS1_k127_4413183_3 1121428.DESHY_110462___1 1.815e-15 81.0 COG1550@1|root,COG1550@2|Bacteria,1VEHY@1239|Firmicutes,24QJY@186801|Clostridia,263AU@186807|Peptococcaceae 186801|Clostridia S Protein of unknown function (DUF503) - - - ko:K09764 - - - - ko00000 - - - DUF503 CMS1_k127_4413183_4 2045.KR76_10750 1.105e-12 77.0 COG0858@1|root,COG0858@2|Bacteria,2IKXP@201174|Actinobacteria,4DR3E@85009|Propionibacteriales 201174|Actinobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA CMS1_k127_4413183_1 264732.Moth_1052 2.237e-64 241.0 COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,42ER4@68295|Thermoanaerobacterales 186801|Clostridia S PFAM phosphoesterase, RecJ domain protein nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 CMS1_k127_4413183_2 471852.Tcur_3327 6.201e-41 157.0 COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4EGVA@85012|Streptosporangiales 201174|Actinobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C,TruB_C_2,TruB_N CMS1_k127_4442933_1 404589.Anae109_1015 5.875e-55 198.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales 28221|Deltaproteobacteria P copper-translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase CMS1_k127_4442933_0 404589.Anae109_4099 4.576e-61 218.0 COG1595@1|root,COG1595@2|Bacteria,1RBM4@1224|Proteobacteria,42S7N@68525|delta/epsilon subdivisions 1224|Proteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4442933_2 570268.ANBB01000058_gene4262 3.582e-53 201.0 COG0702@1|root,COG0702@2|Bacteria,2HC75@201174|Actinobacteria,4ENVD@85012|Streptosporangiales 201174|Actinobacteria GM NmrA-like family - - - - - - - - - - - - NAD_binding_10 CMS1_k127_4442933_3 1183438.GKIL_4309 9.632e-09 63.0 COG1846@1|root,COG1846@2|Bacteria,1G61S@1117|Cyanobacteria 1117|Cyanobacteria K Transcriptional regulator, MarR family - - - - - - - - - - - - MarR,MarR_2 CMS1_k127_4454836_3 1128421.JAGA01000003_gene3397 8.056e-08 55.0 COG0842@1|root,COG0842@2|Bacteria,2NQYW@2323|unclassified Bacteria 2|Bacteria V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane CMS1_k127_4454836_1 1379698.RBG1_1C00001G0602 4.382e-76 280.0 COG0842@1|root,COG0842@2|Bacteria,2NQCU@2323|unclassified Bacteria 2|Bacteria V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane CMS1_k127_4454836_0 1379698.RBG1_1C00001G0603 7.873e-100 336.0 COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria 2|Bacteria V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 CMS1_k127_4454836_2 1379698.RBG1_1C00001G1516 1.649e-12 80.0 COG2982@1|root,COG2982@2|Bacteria,2NRT5@2323|unclassified Bacteria 2|Bacteria M AsmA-like C-terminal region - - - ko:K07289,ko:K09800 - - - - ko00000,ko02000 - - - AsmA,AsmA_1,AsmA_2,DUF3971,DctA-YdbH CMS1_k127_4474043_1 1267535.KB906767_gene1889 2.082e-129 425.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3Y2P5@57723|Acidobacteria,2JMA3@204432|Acidobacteriia 204432|Acidobacteriia G PEP-utilising enzyme, mobile domain - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N CMS1_k127_4474043_2 1120956.JHZK01000032_gene104 2.088e-62 243.0 COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2TV9J@28211|Alphaproteobacteria,1JN87@119043|Rhodobiaceae 28211|Alphaproteobacteria E L-asparaginase II ansA - - - - - - - - - - - Asparaginase_II CMS1_k127_4474043_0 357808.RoseRS_0829 4.404e-206 655.0 COG1012@1|root,COG1012@2|Bacteria,2G5JZ@200795|Chloroflexi,375DB@32061|Chloroflexia 32061|Chloroflexia C Belongs to the aldehyde dehydrogenase family - - - ko:K22187 ko00040,map00040 - R11768 RC00080 ko00000,ko00001,ko01000 - - - Aldedh CMS1_k127_4496233_4 1121946.AUAX01000031_gene977 1.487e-19 99.0 COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria,4D9SI@85008|Micromonosporales 201174|Actinobacteria I Diacylglycerol kinase dagK GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_cat CMS1_k127_4496233_5 1282362.AEAC466_05700 2.933e-18 99.0 COG3146@1|root,COG3146@2|Bacteria,1R5A3@1224|Proteobacteria,2U4MR@28211|Alphaproteobacteria,2KGM3@204458|Caulobacterales 204458|Caulobacterales S Peptidogalycan biosysnthesis/recognition - - - - - - - - - - - - FemAB_like CMS1_k127_4496233_0 1499967.BAYZ01000057_gene4699 2.988e-67 254.0 COG0019@1|root,COG0019@2|Bacteria,2NNQK@2323|unclassified Bacteria 2|Bacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC CMS1_k127_4496233_1 266117.Rxyl_0848 8.423e-54 212.0 COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CPWA@84995|Rubrobacteria 84995|Rubrobacteria V PFAM ABC transporter related - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_4496233_2 56110.Oscil6304_1395 2.512e-52 209.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_4496233_6 649638.Trad_0527 4.627e-16 91.0 COG1183@1|root,COG1183@2|Bacteria 2|Bacteria I phosphatidylcholine synthase activity pcs GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576 2.7.8.24,2.7.8.8 ko:K01004,ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800,R05794 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf CMS1_k127_4496233_3 247156.NFA_14440 2.018e-26 115.0 COG5379@1|root,COG5379@2|Bacteria,2HCAU@201174|Actinobacteria,4G5GG@85025|Nocardiaceae 201174|Actinobacteria I Protein of unknown function (DUF3419) - - - ko:K13622 ko00564,map00564 - R09072 RC00021,RC01091 ko00000,ko00001 - - - DUF3419 CMS1_k127_4499658_3 1144275.COCOR_07153 3.893e-19 103.0 COG3391@1|root,COG3391@2|Bacteria,1QX9W@1224|Proteobacteria,43C32@68525|delta/epsilon subdivisions,2X7DQ@28221|Deltaproteobacteria,2YVS2@29|Myxococcales 28221|Deltaproteobacteria S Stigma-specific protein, Stig1 - - - - - - - - - - - - Stig1 CMS1_k127_4499658_1 1183438.GKIL_1150 4.103e-76 285.0 COG3391@1|root,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria 1117|Cyanobacteria DZ PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,VCBS CMS1_k127_4499658_0 153721.MYP_2783 3.956e-110 379.0 28JBJ@1|root,2Z968@2|Bacteria,4NKZ3@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_4499658_2 398578.Daci_4515 1.475e-53 202.0 COG0823@1|root,COG0841@1|root,COG1361@1|root,COG1572@1|root,COG1657@1|root,COG4733@1|root,COG0823@2|Bacteria,COG0841@2|Bacteria,COG1361@2|Bacteria,COG1572@2|Bacteria,COG1657@2|Bacteria,COG4733@2|Bacteria,1QVSF@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - CARDB,DUF11,DUF1566,Laminin_G_3,OmpA,OmpA_membrane,TIG CMS1_k127_4516322_2 1125863.JAFN01000001_gene2298 6.774e-23 101.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,42T19@68525|delta/epsilon subdivisions,2WQ0M@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - - - - - - - - - - TPR_16,TPR_6 CMS1_k127_4516322_0 370438.PTH_2122 0.0 1054.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,2602D@186807|Peptococcaceae 186801|Clostridia O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N CMS1_k127_4516322_1 1125863.JAFN01000001_gene901 1.118e-32 133.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 CMS1_k127_4516322_3 1121403.AUCV01000073_gene1309 5.423e-07 62.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS1_k127_4516426_2 292459.STH3031 5.771e-23 108.0 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia 186801|Clostridia K TIGRFAM RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4516426_0 1048339.KB913029_gene885 4.681e-173 577.0 COG0643@1|root,COG0643@2|Bacteria,2IBKY@201174|Actinobacteria,4ESB3@85013|Frankiales 201174|Actinobacteria T Histidine kinase cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt CMS1_k127_4516426_1 1123242.JH636434_gene4224 8.979e-29 135.0 COG0835@1|root,COG0835@2|Bacteria,2IZN1@203682|Planctomycetes 203682|Planctomycetes NT CheW domain protein - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW CMS1_k127_4517772_0 1267533.KB906733_gene3472 4.647e-76 278.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria 57723|Acidobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_12,TPR_8 CMS1_k127_4526526_4 469381.Dpep_1062 1.721e-29 121.0 COG0128@1|root,COG0128@2|Bacteria,3TAG4@508458|Synergistetes 508458|Synergistetes E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase CMS1_k127_4526526_2 1234664.AMRO01000060_gene2358 1.626e-43 178.0 COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,4HFZE@91061|Bacilli,1WFCQ@129337|Geobacillus 91061|Bacilli F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin CMS1_k127_4526526_3 1123288.SOV_4c04400 1.402e-30 138.0 COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4H4EK@909932|Negativicutes 909932|Negativicutes I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase CMS1_k127_4526526_1 443143.GM18_3291 3.128e-76 270.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,42MJK@68525|delta/epsilon subdivisions,2WJ8V@28221|Deltaproteobacteria,43SW9@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,UbiA CMS1_k127_4526526_0 1379698.RBG1_1C00001G1225 7.189e-129 423.0 COG0539@1|root,COG0539@2|Bacteria,2NNTP@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein S1 rpsA GO:0005575,GO:0005576,GO:0018995,GO:0020003,GO:0030430,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0065010 1.17.7.4,2.7.11.1 ko:K02945,ko:K03527,ko:K12132 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko01001,ko03011 - - - S1 CMS1_k127_4532498_0 448385.sce1090 4.733e-104 350.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42N0S@68525|delta/epsilon subdivisions,2WMJK@28221|Deltaproteobacteria,2Z3CT@29|Myxococcales 28221|Deltaproteobacteria H tRNA nucleotidyltransferase domain 2 putative - - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 CMS1_k127_4532498_6 287.DR97_3456 0.0002519 53.0 COG5544@1|root,COG5544@2|Bacteria,1N1EG@1224|Proteobacteria,1S9DQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Required for high salt suppression of motility yfiM - - ko:K05811 - - - - ko00000 - - - DUF2279 CMS1_k127_4532498_4 1379698.RBG1_1C00001G0287 2.067e-40 168.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 CMS1_k127_4532498_1 309807.SRU_1513 3.173e-62 224.0 COG0388@1|root,COG0388@2|Bacteria,4NE37@976|Bacteroidetes,1FJTA@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Carbon-nitrogen hydrolase yafV - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase CMS1_k127_4532498_3 246197.MXAN_2999 7.161e-44 184.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,2YVJ7@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 CMS1_k127_4532498_5 671143.DAMO_1636 5.675e-22 103.0 COG0671@1|root,COG0671@2|Bacteria,2NPZ6@2323|unclassified Bacteria 2|Bacteria I Phosphoesterase, PA-phosphatase related - - 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K01096,ko:K19302 ko00550,ko00564,ko01100,map00550,map00564,map01100 - R02029,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 - - - PAP2 CMS1_k127_4532498_2 1379698.RBG1_1C00001G0340 1.077e-47 189.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NNRF@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2 CMS1_k127_4541208_1 886293.Sinac_3963 1.29e-73 254.0 COG2234@1|root,COG2234@2|Bacteria,2IWTP@203682|Planctomycetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_4541208_0 880073.Calab_1134 6.158e-120 417.0 COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS1_k127_4541208_2 1123073.KB899241_gene2226 1.755e-34 136.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1X333@135614|Xanthomonadales 135614|Xanthomonadales I converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 CMS1_k127_4545756_0 1307761.L21SP2_0925 3.149e-110 374.0 COG0136@1|root,COG0136@2|Bacteria,2J5ZP@203691|Spirochaetes 203691|Spirochaetes E Belongs to the aspartate-semialdehyde dehydrogenase family asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC CMS1_k127_4545756_1 868864.Dester_0258 1.691e-30 138.0 COG0406@1|root,COG0406@2|Bacteria,2G423@200783|Aquificae 200783|Aquificae G PFAM Phosphoglycerate mutase pgmA - 3.1.3.3 ko:K22305 ko00260,ko00680,ko01100,ko01120,ko01130,map00260,map00680,map01100,map01120,map01130 - R00582 RC00017 ko00000,ko00001,ko01000 - - - His_Phos_1 CMS1_k127_4546730_1 592015.HMPREF1705_00673 9.449e-74 256.0 COG0683@1|root,COG0683@2|Bacteria,3TCMB@508458|Synergistetes 508458|Synergistetes E Protein of unknown function (DUF3798) - - - - - - - - - - - - DUF3798 CMS1_k127_4546730_0 1009370.ALO_08008 1.33e-188 602.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H2EG@909932|Negativicutes 909932|Negativicutes G ABC transporter - - - - - - - - - - - - ABC_tran CMS1_k127_4551381_0 243231.GSU0017 3.254e-242 782.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,43TS2@69541|Desulfuromonadales 28221|Deltaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF CMS1_k127_4551381_1 1242864.D187_001185 9.841e-14 84.0 COG2304@1|root,COG2304@2|Bacteria,1NX8F@1224|Proteobacteria,430QD@68525|delta/epsilon subdivisions,2WVNR@28221|Deltaproteobacteria,2YW4W@29|Myxococcales 28221|Deltaproteobacteria S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA,VWA_2 CMS1_k127_4555644_1 506534.Rhein_0329 3.067e-15 83.0 COG1983@1|root,COG1983@2|Bacteria 2|Bacteria KT positive regulation of macromolecule biosynthetic process - - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC CMS1_k127_4555644_0 1121017.AUFG01000010_gene1661 3.061e-35 136.0 COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4FEQ1@85021|Intrasporangiaceae 201174|Actinobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt CMS1_k127_4560435_7 493475.GARC_2783 2.432e-51 184.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,468D5@72275|Alteromonadaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_4560435_5 671143.DAMO_3032 6.763e-101 335.0 COG0861@1|root,COG0861@2|Bacteria,2NQFQ@2323|unclassified Bacteria 2|Bacteria P Integral membrane protein TerC family terC - - - - - - - - - - - TerC CMS1_k127_4560435_3 1123073.KB899241_gene2287 9.666e-126 413.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X7MH@135614|Xanthomonadales 135614|Xanthomonadales E Glycine cleavage T-protein C-terminal barrel domain - - - - - - - - - - - - GCV_T,GCV_T_C CMS1_k127_4560435_0 204669.Acid345_1270 1.211e-205 652.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 CMS1_k127_4560435_6 234267.Acid_7336 6.661e-82 311.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria 57723|Acidobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 CMS1_k127_4560435_4 616991.JPOO01000001_gene4549 6.442e-118 389.0 COG2159@1|root,COG2159@2|Bacteria,4NJP9@976|Bacteroidetes,1HXKV@117743|Flavobacteriia,23FXD@178469|Arenibacter 976|Bacteroidetes S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 CMS1_k127_4560435_2 756272.Plabr_3432 1.583e-134 438.0 COG4260@1|root,COG4260@2|Bacteria,2IYIR@203682|Planctomycetes 203682|Planctomycetes S virion core protein (lumpy skin disease virus) - - - - - - - - - - - - Band_7_1,DUF4339 CMS1_k127_4560435_9 502025.Hoch_4700 5.736e-32 139.0 COG3809@1|root,COG3809@2|Bacteria,1QJZM@1224|Proteobacteria,43E52@68525|delta/epsilon subdivisions,2X98E@28221|Deltaproteobacteria,2Z2KB@29|Myxococcales 28221|Deltaproteobacteria S Transcription factor zinc-finger - - - - - - - - - - - - zf-TFIIB CMS1_k127_4560435_1 234267.Acid_7636 7.218e-189 635.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria 57723|Acidobacteria KLTU Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40,Pkinase CMS1_k127_4560435_10 316274.Haur_3513 4.749e-16 89.0 COG0705@1|root,COG0705@2|Bacteria,2G7BZ@200795|Chloroflexi,375SV@32061|Chloroflexia 32061|Chloroflexia S PFAM Rhomboid family protein - - 3.4.21.105 ko:K19225 - - - - ko00000,ko01000,ko01002 - - - Rhomboid CMS1_k127_4560435_8 391008.Smal_0118 2.472e-32 133.0 COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,1RZA4@1236|Gammaproteobacteria,1X7KS@135614|Xanthomonadales 135614|Xanthomonadales S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1 CMS1_k127_4561617_0 443143.GM18_3499 1.453e-183 582.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,43U3Y@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N CMS1_k127_4561617_1 1303518.CCALI_01897 4.237e-32 132.0 COG1595@1|root,COG1595@2|Bacteria 1303518.CCALI_01897|- K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - - CMS1_k127_4561617_2 483219.LILAB_31245 0.0001718 51.0 COG5662@1|root,COG5662@2|Bacteria,1Q8RV@1224|Proteobacteria,43448@68525|delta/epsilon subdivisions,2X557@28221|Deltaproteobacteria,2Z04T@29|Myxococcales 28221|Deltaproteobacteria K Putative zinc-finger - - - - - - - - - - - - zf-HC2 CMS1_k127_4564665_1 266117.Rxyl_1639 3.388e-07 51.0 COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4CPD1@84995|Rubrobacteria 84995|Rubrobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt CMS1_k127_4564665_0 1379698.RBG1_1C00001G0153 3.863e-238 742.0 COG0055@1|root,COG0055@2|Bacteria,2NNRB@2323|unclassified Bacteria 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N CMS1_k127_4567087_2 509191.AEDB02000022_gene2925 2.456e-08 59.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,3WIT1@541000|Ruminococcaceae 186801|Clostridia O Subtilase family - - - ko:K13274,ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Big_2,Peptidase_S8,SLH CMS1_k127_4567087_1 1121918.ARWE01000001_gene1426 2.85e-09 70.0 COG5276@1|root,COG5276@2|Bacteria,1RBM1@1224|Proteobacteria,42TF9@68525|delta/epsilon subdivisions,2WPX5@28221|Deltaproteobacteria,43SNG@69541|Desulfuromonadales 28221|Deltaproteobacteria S LVIVD repeat - - - - - - - - - - - - LVIVD CMS1_k127_4567087_0 880073.Calab_2082 6.378e-18 98.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF11,DUF4114,DUF4157 CMS1_k127_4569429_0 404589.Anae109_4442 1.014e-33 150.0 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - DUF222,HNH CMS1_k127_4575826_2 1187851.A33M_3193 9.502e-74 266.0 COG1063@1|root,COG1063@2|Bacteria,1QTU5@1224|Proteobacteria,2TW9Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology yphC - 1.1.1.368 ko:K07538 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05581 RC00850 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_N_assoc,ADH_zinc_N CMS1_k127_4575826_3 991905.SL003B_1081 7.656e-32 133.0 COG1309@1|root,COG1309@2|Bacteria,1MY9K@1224|Proteobacteria,2U3PH@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - TetR_N CMS1_k127_4575826_0 1379698.RBG1_1C00001G0607 3.422e-133 454.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 CMS1_k127_4575826_4 1267534.KB906754_gene3444 7.727e-16 84.0 COG4319@1|root,COG4319@2|Bacteria,3Y5FP@57723|Acidobacteria,2JN7M@204432|Acidobacteriia 204432|Acidobacteriia S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS1_k127_4575826_1 1128421.JAGA01000001_gene2203 6.276e-104 354.0 COG4579@1|root,COG4579@2|Bacteria 2|Bacteria F [isocitrate dehydrogenase (NADP+)] phosphatase activity aceK GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK CMS1_k127_4585280_1 945713.IALB_1883 3.66e-93 325.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 CMS1_k127_4585280_2 1197477.IA57_03430 4.846e-13 75.0 COG3577@1|root,COG3577@2|Bacteria,4NNI0@976|Bacteroidetes,1I1Z6@117743|Flavobacteriia 976|Bacteroidetes S protease - - - - - - - - - - - - Asp_protease_2 CMS1_k127_4585280_0 497964.CfE428DRAFT_5426 7.325e-124 404.0 COG1680@1|root,COG1680@2|Bacteria,46WGY@74201|Verrucomicrobia 74201|Verrucomicrobia V COG1680 Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - - CMS1_k127_4585555_5 224324.aq_1474 5.826e-87 300.0 COG2804@1|root,COG2804@2|Bacteria,2G4H7@200783|Aquificae 200783|Aquificae NU PFAM Type II secretion system protein E - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N CMS1_k127_4585555_1 1120971.AUCA01000054_gene345 2.124e-158 532.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,4H9X4@91061|Bacilli,2791D@186823|Alicyclobacillaceae 91061|Bacilli J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon CMS1_k127_4585555_4 1379698.RBG1_1C00001G0449 1.81e-93 321.0 COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria 2|Bacteria M ABC-type transport system involved in lipoprotein release permease component lolC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD CMS1_k127_4585555_6 519989.ECTPHS_10671 5.221e-68 240.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1WVXB@135613|Chromatiales 135613|Chromatiales V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran CMS1_k127_4585555_7 1536775.H70737_27720 5.427e-47 175.0 COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,4HH4R@91061|Bacilli,26R52@186822|Paenibacillaceae 91061|Bacilli S protein with conserved CXXC pairs mcsA GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 - ko:K19411 - - - - ko00000 - - - UVR CMS1_k127_4585555_3 264732.Moth_0161 1.989e-96 336.0 COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,247SS@186801|Clostridia,42FMU@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the specific phosphorylation of arginine residues in proteins mcsB - 2.7.14.1 ko:K19405 - - R11090 RC00002,RC00203 ko00000,ko01000 - - - ATP-gua_Ptrans CMS1_k127_4585555_0 246194.CHY_2348 5e-323 1006.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales 186801|Clostridia O Belongs to the ClpA ClpB family clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR CMS1_k127_4585555_2 1379698.RBG1_1C00001G1846 1.177e-132 474.0 COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria 2|Bacteria M Surface antigen bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA CMS1_k127_4591501_2 861299.J421_1983 1.963e-31 138.0 COG1538@1|root,COG1538@2|Bacteria,1ZT9S@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS1_k127_4591501_1 1379698.RBG1_1C00001G0513 2.801e-135 445.0 COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria 2|Bacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA3 - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like CMS1_k127_4591501_0 767817.Desgi_3972 8.014e-166 533.0 COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,264EG@186807|Peptococcaceae 186801|Clostridia C aldehyde oxidase and xanthine dehydrogenase a b hammerhead - - 1.17.1.4 ko:K00087 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 CMS1_k127_459234_0 1123072.AUDH01000038_gene152 7.343e-123 410.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U9M6@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 CMS1_k127_459234_1 314285.KT71_18451 2.165e-11 74.0 COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,1S32X@1236|Gammaproteobacteria,1J70B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 CMS1_k127_4598621_0 861299.J421_2327 3.507e-64 230.0 COG2885@1|root,COG2885@2|Bacteria,1ZUV2@142182|Gemmatimonadetes 142182|Gemmatimonadetes M OmpA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA CMS1_k127_4598621_4 521097.Coch_0152 0.0004736 50.0 COG4980@1|root,COG4980@2|Bacteria,4NUNV@976|Bacteroidetes,1IJ5H@117743|Flavobacteriia,1ES8C@1016|Capnocytophaga 976|Bacteroidetes S YtxH-like protein - - - - - - - - - - - - YtxH CMS1_k127_4598621_1 1120972.AUMH01000001_gene1215 6.302e-28 127.0 COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,4H9SR@91061|Bacilli,277XW@186823|Alicyclobacillaceae 91061|Bacilli S AI-2E family transporter yrrI GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - AI-2E_transport CMS1_k127_4598621_2 1173026.Glo7428_3072 3.937e-10 61.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1G0P4@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg CMS1_k127_4615276_2 326427.Cagg_1133 3.539e-73 256.0 COG4770@1|root,COG4770@2|Bacteria,2GBIE@200795|Chloroflexi,374S0@32061|Chloroflexia 32061|Chloroflexia I Carbamoyl-phosphate synthetase large chain domain protein - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 CMS1_k127_4615276_3 1123269.NX02_06565 9.699e-16 90.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2K27B@204457|Sphingomonadales 204457|Sphingomonadales I acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 CMS1_k127_4615276_1 1121405.dsmv_1899 8.202e-95 331.0 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,42Q6T@68525|delta/epsilon subdivisions,2WIN1@28221|Deltaproteobacteria,2MIW0@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM pyruvate carboxyltransferase mvaB - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like CMS1_k127_4615276_0 1123242.JH636435_gene2052 1.558e-118 403.0 COG0475@1|root,COG0475@2|Bacteria,2IZ8F@203682|Planctomycetes 203682|Planctomycetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger CMS1_k127_4615276_4 296591.Bpro_2074 1.013e-12 78.0 COG0457@1|root,COG0457@2|Bacteria 296591.Bpro_2074|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_4624976_2 1385935.N836_04780 1.554e-58 215.0 COG3264@1|root,COG3264@2|Bacteria,1G2UD@1117|Cyanobacteria,1H8A1@1150|Oscillatoriales 1117|Cyanobacteria M mechanosensitive ion channel - - - - - - - - - - - - DEP,MS_channel CMS1_k127_4624976_1 518766.Rmar_0040 1.662e-96 340.0 COG2126@1|root,COG2126@2|Bacteria,4NEX1@976|Bacteroidetes 976|Bacteroidetes J Pfam Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans CMS1_k127_4624976_0 1128421.JAGA01000004_gene2674 3.577e-277 859.0 COG0366@1|root,COG0366@2|Bacteria,2NQND@2323|unclassified Bacteria 2|Bacteria G Maltogenic Amylase, C-terminal domain treS - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C CMS1_k127_4624976_3 671143.DAMO_1539 3.646e-58 218.0 COG0463@1|root,COG0463@2|Bacteria,2NQD9@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferase family 2 - - 2.4.1.268 ko:K21349 - - - - ko00000,ko01000 - GT81 - Glycos_transf_2 CMS1_k127_4624976_4 330214.NIDE4206 1.474e-25 115.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport cmpX - - - - - - - - - - - MS_channel,TM_helix CMS1_k127_4624976_5 404589.Anae109_3070 4.681e-10 68.0 COG0296@1|root,COG3281@1|root,COG0296@2|Bacteria,COG3281@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2Z34A@29|Myxococcales 28221|Deltaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 CMS1_k127_4628939_1 429009.Adeg_1012 1.232e-62 227.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,42F3M@68295|Thermoanaerobacterales 186801|Clostridia T PFAM ATP-binding region, ATPase domain protein phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like CMS1_k127_4628939_0 292459.STH746 1.31e-103 345.0 COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia 186801|Clostridia P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran CMS1_k127_4628939_2 379066.GAU_2370 8.375e-16 83.0 COG0704@1|root,COG0704@2|Bacteria 2|Bacteria P negative regulation of phosphate transmembrane transport phoU GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU CMS1_k127_4629273_1 1120985.AUMI01000015_gene1514 9.727e-72 251.0 COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,4H1YQ@909932|Negativicutes 909932|Negativicutes C FeS-containing Cyanobacterial-specific oxidoreductase - - - - - - - - - - - - DUF512 CMS1_k127_4629273_3 935836.JAEL01000201_gene4586 0.0006429 45.0 2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - CMS1_k127_4629273_2 269799.Gmet_2052 1.033e-69 251.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,43U4M@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT CMS1_k127_4629273_0 309807.SRU_1712 7.588e-90 315.0 COG0323@1|root,COG0323@2|Bacteria,4NDWJ@976|Bacteroidetes,1FJ3S@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C CMS1_k127_4631073_3 251221.35214317 1.886e-13 84.0 COG3307@1|root,COG3307@2|Bacteria,1G1ZH@1117|Cyanobacteria 1117|Cyanobacteria M bicarbonate transporter, IctB family ictB - - ko:K18814 - - - - ko00000,ko02000 9.B.67.1 - - Wzy_C CMS1_k127_4631073_2 243231.GSU1488 5.495e-33 147.0 COG0392@1|root,COG0392@2|Bacteria,1N7DR@1224|Proteobacteria,42N4R@68525|delta/epsilon subdivisions,2WS5Z@28221|Deltaproteobacteria,43TTU@69541|Desulfuromonadales 28221|Deltaproteobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS1_k127_4631073_0 497964.CfE428DRAFT_4472 1.844e-81 285.0 COG1899@1|root,COG1899@2|Bacteria 2|Bacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - CMS1_k127_4631073_1 1379698.RBG1_1C00001G1249 1.863e-49 187.0 COG3170@1|root,COG3170@2|Bacteria,2NPQF@2323|unclassified Bacteria 2|Bacteria NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 CMS1_k127_4631181_0 1089550.ATTH01000001_gene1136 3.042e-216 686.0 COG0348@1|root,COG0492@1|root,COG1249@1|root,COG0348@2|Bacteria,COG0492@2|Bacteria,COG1249@2|Bacteria,4PIT2@976|Bacteroidetes,1FJYA@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 CMS1_k127_4631181_2 1394178.AWOO02000009_gene4242 2.539e-35 144.0 COG0500@1|root,COG2226@2|Bacteria,2I5FG@201174|Actinobacteria 201174|Actinobacteria Q Methionine biosynthesis protein MetW - - - - - - - - - - - - - CMS1_k127_4631181_1 1278073.MYSTI_01153 3.466e-43 183.0 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2WPGW@28221|Deltaproteobacteria,2Z1ZU@29|Myxococcales 28221|Deltaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_4639815_0 1125863.JAFN01000001_gene929 2.042e-179 608.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 CMS1_k127_4639815_2 1227739.Hsw_4080 8.103e-08 65.0 COG4775@1|root,COG4775@2|Bacteria,4NF35@976|Bacteroidetes,47NVM@768503|Cytophagia 976|Bacteroidetes M Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,POTRA,ShlB CMS1_k127_4639815_1 1089550.ATTH01000001_gene2273 6.678e-25 122.0 COG5448@1|root,COG5448@2|Bacteria,4NGRS@976|Bacteroidetes,1FJ4S@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Glycoside hydrolase family 24 - - - - - - - - - - - - - CMS1_k127_4654903_0 382464.ABSI01000006_gene754 5.471e-118 383.0 COG0459@1|root,COG0459@2|Bacteria,46S9U@74201|Verrucomicrobia,2ITQ1@203494|Verrucomicrobiae 203494|Verrucomicrobiae O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS1_k127_4654903_1 478741.JAFS01000002_gene477 5.083e-33 132.0 COG0234@1|root,COG0234@2|Bacteria,46SZ8@74201|Verrucomicrobia,37GWD@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 CMS1_k127_4654903_2 1219035.NT2_09_00480 1.229e-21 109.0 COG1807@1|root,COG1807@2|Bacteria,1N5WU@1224|Proteobacteria,2TZ8U@28211|Alphaproteobacteria,2K2JP@204457|Sphingomonadales 204457|Sphingomonadales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 CMS1_k127_4679244_3 1122918.KB907263_gene307 2.074e-23 103.0 COG0400@1|root,COG0400@2|Bacteria,1TPBY@1239|Firmicutes,4HB45@91061|Bacilli,26QI2@186822|Paenibacillaceae 91061|Bacilli S Carboxylesterase yahD - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2,DLH CMS1_k127_4679244_0 381764.Fnod_0767 2.487e-187 604.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GC1W@200918|Thermotogae 200918|Thermotogae H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source - - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase CMS1_k127_4679244_4 670487.Ocepr_1916 1.191e-17 89.0 COG1611@1|root,COG1611@2|Bacteria,1WIGV@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Rossmann fold nucleotide-binding protein - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox CMS1_k127_4679244_1 1160707.AJIK01000024_gene1728 2.744e-55 209.0 COG0318@1|root,COG0318@2|Bacteria,1UKBR@1239|Firmicutes,4ITH5@91061|Bacilli,26GS4@186818|Planococcaceae 91061|Bacilli IQ Acyl-protein synthetase, LuxE - - - - - - - - - - - - LuxE CMS1_k127_4679244_2 365046.Rta_22750 7.979e-51 205.0 COG1012@1|root,COG1012@2|Bacteria,1R656@1224|Proteobacteria,2VPB8@28216|Betaproteobacteria,4ACVM@80864|Comamonadaceae 28216|Betaproteobacteria C Acyl-CoA reductase (LuxC) - - - - - - - - - - - - LuxC CMS1_k127_4680505_0 497964.CfE428DRAFT_0348 5.416e-66 250.0 COG0612@1|root,COG0612@2|Bacteria,46S9I@74201|Verrucomicrobia 74201|Verrucomicrobia S PFAM peptidase M16 domain protein - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_4703384_1 926549.KI421517_gene1102 4.788e-09 59.0 COG0697@1|root,COG0697@2|Bacteria,4NGJR@976|Bacteroidetes,47N5J@768503|Cytophagia 976|Bacteroidetes EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_4703384_0 1125863.JAFN01000001_gene127 3.165e-11 76.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - - - - - - - - - - Esterase_phd,Laminin_G_3,PA14,fn3 CMS1_k127_4706842_0 1242864.D187_006544 2.557e-98 331.0 COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales 28221|Deltaproteobacteria M Glycosyl transferase family 21 - - - - - - - - - - - - Glyco_tranf_2_3 CMS1_k127_4706842_1 1232410.KI421421_gene3320 1.75e-43 174.0 COG0500@1|root,COG2226@2|Bacteria,1R2WX@1224|Proteobacteria,42QTU@68525|delta/epsilon subdivisions,2X8NZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q methyltransferase - - - - - - - - - - - - - CMS1_k127_4708859_5 244581.IM40_05935 3.658e-42 159.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria,47ETX@766|Rickettsiales 766|Rickettsiales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus CMS1_k127_4708859_1 459349.CLOAM0355 8.112e-120 404.0 COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 CMS1_k127_4708859_4 1266914.ATUK01000013_gene1864 6.231e-56 202.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1WX8U@135613|Chromatiales 135613|Chromatiales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin CMS1_k127_4708859_0 1379698.RBG1_1C00001G1837 4.902e-196 617.0 COG1260@1|root,COG1260@2|Bacteria,2NNVE@2323|unclassified Bacteria 2|Bacteria I Myo-inositol-1-phosphate synthase ino1 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth CMS1_k127_4708859_6 1122182.KB903825_gene320 6.213e-35 141.0 COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4DCRP@85008|Micromonosporales 201174|Actinobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA1 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 ko:K00995,ko:K00999 ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070 - R01801,R01802 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf CMS1_k127_4708859_3 1121468.AUBR01000004_gene158 3.505e-69 257.0 COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,42F0X@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase CMS1_k127_4708859_2 483219.LILAB_01575 6.764e-81 284.0 COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria,2YUBW@29|Myxococcales 28221|Deltaproteobacteria E Threonine aldolase ltaA - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS1_k127_4708859_7 880073.Calab_2436 8.082e-22 98.0 COG2738@1|root,COG2738@2|Bacteria,2NPB1@2323|unclassified Bacteria 2|Bacteria S Putative neutral zinc metallopeptidase yugP - - ko:K06973 - - - - ko00000 - - - Zn_peptidase_2 CMS1_k127_4712126_2 626418.bglu_1g14980 2.71e-14 82.0 COG0859@1|root,COG0859@2|Bacteria,1R57H@1224|Proteobacteria,2VHFC@28216|Betaproteobacteria,1K0TC@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM glycosyl transferase family 9 - - - - - - - - - - - - Glyco_transf_9 CMS1_k127_4712126_3 509191.AEDB02000109_gene4961 4.568e-08 64.0 COG5662@1|root,COG5662@2|Bacteria,1VKS6@1239|Firmicutes,24VD1@186801|Clostridia,3WM8H@541000|Ruminococcaceae 186801|Clostridia K Putative zinc-finger - - - - - - - - - - - - zf-HC2 CMS1_k127_4712126_1 1382359.JIAL01000001_gene1618 1.398e-45 172.0 COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria,2JIDF@204432|Acidobacteriia 204432|Acidobacteriia K RNA polymerase sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4712126_0 1304888.ATWF01000001_gene1634 5.911e-64 228.0 COG2204@1|root,COG2204@2|Bacteria,2GF3B@200930|Deferribacteres 200930|Deferribacteres T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_4720788_0 1144275.COCOR_06151 4.258e-34 144.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2WM19@28221|Deltaproteobacteria,2YV46@29|Myxococcales 28221|Deltaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,TPR_1,TPR_16,TPR_2,VWA,VWA_2 CMS1_k127_4720788_1 1297742.A176_05198 1.548e-06 61.0 COG0457@1|root,COG0457@2|Bacteria,1PYTB@1224|Proteobacteria,42VYS@68525|delta/epsilon subdivisions,2XA0E@28221|Deltaproteobacteria,2YW26@29|Myxococcales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2 CMS1_k127_4727999_2 518766.Rmar_1341 1.077e-05 50.0 COG4288@1|root,COG4288@2|Bacteria,4NHM6@976|Bacteroidetes,1FJ2N@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Lamin Tail Domain - - - - - - - - - - - - Big_5,CHU_C,LTD CMS1_k127_4727999_0 264732.Moth_1955 9.124e-146 472.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales 186801|Clostridia E PFAM aminotransferase, class I - - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_4727999_1 1232410.KI421413_gene725 4.161e-98 347.0 COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,42M16@68525|delta/epsilon subdivisions,2WM0V@28221|Deltaproteobacteria,43UMW@69541|Desulfuromonadales 28221|Deltaproteobacteria E Amino acid kinase family cpkA - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase CMS1_k127_4730779_3 502025.Hoch_6436 1.287e-29 119.0 COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,1MU50@1224|Proteobacteria,43B2B@68525|delta/epsilon subdivisions,2X6GC@28221|Deltaproteobacteria,2Z3AZ@29|Myxococcales 28221|Deltaproteobacteria K Pfam:DUF955 - - - ko:K07110 - - - - ko00000,ko03000 - - - DUF2083,HTH_3,HTH_31,Peptidase_M78 CMS1_k127_4730779_0 661478.OP10G_1093 1.35e-60 216.0 COG2207@1|root,COG4312@1|root,COG2207@2|Bacteria,COG4312@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF899) - - - ko:K21701 - - - - ko00000,ko03000 - - - Arabinose_bd,DUF899,HTH_18 CMS1_k127_4730779_1 1142394.PSMK_27880 8.088e-53 201.0 COG2017@1|root,COG2017@2|Bacteria,2J49D@203682|Planctomycetes 203682|Planctomycetes G converts alpha-aldose to the beta-anomer - - - - - - - - - - - - - CMS1_k127_4730779_2 335659.S23_23250 6.679e-35 141.0 COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria,3JYDJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin CMS1_k127_4730779_4 452637.Oter_1107 1.489e-25 116.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,46V45@74201|Verrucomicrobia 74201|Verrucomicrobia K helix_turn_helix, mercury resistance - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 CMS1_k127_4738549_0 1254432.SCE1572_27170 2.644e-145 480.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 CMS1_k127_4738549_1 1396141.BATP01000014_gene2754 6.086e-08 62.0 COG1579@1|root,COG1579@2|Bacteria,46T10@74201|Verrucomicrobia,2IUE8@203494|Verrucomicrobiae 203494|Verrucomicrobiae S C4-type zinc ribbon domain - - - ko:K07164 - - - - ko00000 - - - zf-RING_7 CMS1_k127_4738985_0 1120971.AUCA01000035_gene2806 6.606e-136 448.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,278UP@186823|Alicyclobacillaceae 91061|Bacilli NU type II secretion system protein E pilB - - ko:K02243,ko:K02652 - M00429 - - ko00000,ko00002,ko02035,ko02044 3.A.14.1,3.A.15.2 - - T2SSE,T2SSE_N CMS1_k127_4738985_1 1121438.JNJA01000006_gene221 1.6e-82 288.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2M9D6@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM type II secretion system - - - ko:K02653,ko:K12278 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF CMS1_k127_4738985_2 511051.CSE_14670 1.72e-20 96.0 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pilA GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - ko:K02650,ko:K02655 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl,Pilin_PilA CMS1_k127_4738985_3 10160.XP_004624987.1 1.248e-14 90.0 28K3T@1|root,2QSIA@2759|Eukaryota,3974K@33154|Opisthokonta,3BBX0@33208|Metazoa,3CV1I@33213|Bilateria,485N6@7711|Chordata,4962A@7742|Vertebrata,3JD7X@40674|Mammalia,35B3B@314146|Euarchontoglires,4PVC6@9989|Rodentia 33208|Metazoa S Protein of unknown function (DUF2723) TMEM260 - - - - - - - - - - - DUF2723 CMS1_k127_4738985_4 1142394.PSMK_14340 8.591e-10 70.0 COG4970@1|root,COG4970@2|Bacteria,2J1P5@203682|Planctomycetes 203682|Planctomycetes NU Prokaryotic N-terminal methylation motif - - - ko:K02457 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspH,N_methyl CMS1_k127_4739935_1 644966.Tmar_0842 1.207e-133 437.0 COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,3WCJS@538999|Clostridiales incertae sedis 186801|Clostridia J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b CMS1_k127_4739935_0 1379698.RBG1_1C00001G1562 2.413e-191 620.0 COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria 2|Bacteria M Transglycosylase mrcA GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase CMS1_k127_4739935_4 404589.Anae109_2479 1.898e-64 229.0 COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,43EF3@68525|delta/epsilon subdivisions,2X0ID@28221|Deltaproteobacteria,2Z1N2@29|Myxococcales 28221|Deltaproteobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_4739935_2 448385.sce2436 4.249e-113 392.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,42PCD@68525|delta/epsilon subdivisions,2WKGQ@28221|Deltaproteobacteria,2YU9M@29|Myxococcales 28221|Deltaproteobacteria F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis pdp - 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C CMS1_k127_4739935_5 1121468.AUBR01000015_gene2278 3.395e-33 143.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,42FFH@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC CMS1_k127_4739935_6 1121090.KB894686_gene3089 3.003e-25 119.0 COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,4HIJ3@91061|Bacilli,1ZG79@1386|Bacillus 91061|Bacilli F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis cdd GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009972,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042454,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - iYO844.BSU25300 dCMP_cyt_deam_1,dCMP_cyt_deam_2 CMS1_k127_4739935_3 56780.SYN_01482 1.111e-105 356.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2WIVG@28221|Deltaproteobacteria,2MQVF@213462|Syntrophobacterales 28221|Deltaproteobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N CMS1_k127_4743916_2 646529.Desaci_3461 6.502e-31 126.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,25ZZ7@186807|Peptococcaceae 186801|Clostridia E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 CMS1_k127_4743916_1 278957.ABEA03000080_gene3199 4.447e-49 197.0 COG0652@1|root,COG0652@2|Bacteria,46VEN@74201|Verrucomicrobia,3K93U@414999|Opitutae 414999|Opitutae O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - - - - - - - - - - - Pro_isomerase CMS1_k127_4743916_4 670487.Ocepr_1236 2.401e-10 75.0 COG0457@1|root,COG0457@2|Bacteria,1WIGW@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 CMS1_k127_4743916_3 237368.SCABRO_02281 8.86e-25 115.0 COG0457@1|root,COG0457@2|Bacteria 237368.SCABRO_02281|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_4743916_0 309801.trd_A0017 6.047e-143 475.0 COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi,27Y2X@189775|Thermomicrobia 189775|Thermomicrobia O Magnesium chelatase, subunit ChlI - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C CMS1_k127_4743916_5 374847.Kcr_0655 1.455e-07 63.0 COG1011@1|root,arCOG02291@2157|Archaea 2157|Archaea S hydrolase (HAD superfamily) - - - ko:K07025 - - - - ko00000 - - - HAD_2 CMS1_k127_4743916_6 1121479.AUBS01000032_gene245 2.927e-07 57.0 COG1893@1|root,COG1893@2|Bacteria,1N0M5@1224|Proteobacteria,2TTAN@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C CMS1_k127_4747649_2 221360.RS9917_07640 0.000109 53.0 COG0457@1|root,COG0457@2|Bacteria,1G1UY@1117|Cyanobacteria,1H1DP@1129|Synechococcus 1117|Cyanobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8 CMS1_k127_4747649_0 880073.Calab_0781 8.27e-38 157.0 COG1595@1|root,COG1595@2|Bacteria,2NR5T@2323|unclassified Bacteria 2|Bacteria K TIGRFAM RNA polymerase sigma factor, sigma-70 family sigG - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4747649_1 561175.KB894103_gene1326 1.705e-05 56.0 COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria,4EJZ2@85012|Streptosporangiales 201174|Actinobacteria K Anti-sigma-K factor rskA - - - - - - - - - - - - RskA,zf-HC2 CMS1_k127_4749697_1 518766.Rmar_1429 2.481e-05 56.0 COG3292@1|root,COG3292@2|Bacteria,4NI2T@976|Bacteroidetes 976|Bacteroidetes T Two component regulator propeller - - - - - - - - - - - - Reg_prop,YceI CMS1_k127_4749697_0 1121918.ARWE01000001_gene1797 1.492e-14 86.0 COG1404@1|root,COG1404@2|Bacteria,1QYWU@1224|Proteobacteria,42VXP@68525|delta/epsilon subdivisions,2X7PK@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - CMS1_k127_4761969_0 1408433.JHXV01000027_gene3728 2.262e-88 326.0 COG2208@1|root,COG3292@1|root,COG4191@1|root,COG2208@2|Bacteria,COG3292@2|Bacteria,COG4191@2|Bacteria,4NG28@976|Bacteroidetes,1I1IG@117743|Flavobacteriia 976|Bacteroidetes KT regulator - - - - - - - - - - - - GerE,Reg_prop,Y_Y_Y CMS1_k127_48032_1 1121430.JMLG01000001_gene2113 1.361e-28 123.0 COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,26141@186807|Peptococcaceae 186801|Clostridia J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 CMS1_k127_48032_0 1125863.JAFN01000001_gene3585 1.336e-157 525.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria 28221|Deltaproteobacteria D PFAM cell divisionFtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma CMS1_k127_48032_2 926560.KE387023_gene2739 1.152e-14 74.0 COG0499@1|root,COG0499@2|Bacteria,1WKSY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD CMS1_k127_4807191_2 1128421.JAGA01000002_gene1226 1.198e-54 215.0 COG1606@1|root,COG1606@2|Bacteria,2NP5T@2323|unclassified Bacteria 2|Bacteria L tRNA processing larE - 4.99.1.12 ko:K06864,ko:K09121 - - - - ko00000,ko01000 - - - ATP_bind_3,Asn_synthase,NAD_synthase,QueC CMS1_k127_4807191_1 330214.NIDE1709 8.666e-67 250.0 COG1559@1|root,COG1559@2|Bacteria,3J0IR@40117|Nitrospirae 40117|Nitrospirae S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG CMS1_k127_4807191_5 1121439.dsat_1861 3.118e-12 79.0 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,42UC6@68525|delta/epsilon subdivisions,2WPDD@28221|Deltaproteobacteria,2MBU6@213115|Desulfovibrionales 28221|Deltaproteobacteria J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX CMS1_k127_4807191_0 477974.Daud_0949 1.607e-78 273.0 COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,2607F@186807|Peptococcaceae 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 CMS1_k127_4807191_4 926692.AZYG01000072_gene2721 6.463e-25 115.0 COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,3WAWR@53433|Halanaerobiales 186801|Clostridia MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 CMS1_k127_4807191_3 861299.J421_3049 4.278e-42 157.0 COG1734@1|root,COG1734@2|Bacteria,1ZTP9@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR CMS1_k127_4822693_5 861299.J421_3276 1.632e-17 83.0 COG0105@1|root,COG0105@2|Bacteria,1ZTTD@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NDK - - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK CMS1_k127_4822693_4 1499967.BAYZ01000186_gene3964 5.952e-21 98.0 COG1399@1|root,COG1399@2|Bacteria,2NPVD@2323|unclassified Bacteria 2|Bacteria S Uncharacterized ACR, COG1399 yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - ko:K07040 - - - - ko00000 - - - DUF177 CMS1_k127_4822693_3 1379698.RBG1_1C00001G1829 2.658e-21 94.0 COG0333@1|root,COG0333@2|Bacteria,2NQ1M@2323|unclassified Bacteria 2|Bacteria J Ribosomal L32p protein family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p CMS1_k127_4822693_1 635013.TherJR_2078 2.181e-96 326.0 COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,2610G@186807|Peptococcaceae 186801|Clostridia I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis CMS1_k127_4822693_0 401526.TcarDRAFT_2187 5.734e-108 379.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4H2A2@909932|Negativicutes 909932|Negativicutes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C CMS1_k127_4822693_2 234267.Acid_2598 1.85e-35 147.0 COG0331@1|root,COG0331@2|Bacteria,3Y2TE@57723|Acidobacteria 57723|Acidobacteria I malonyl CoA-acyl carrier protein transacylase - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 CMS1_k127_4828990_0 1382356.JQMP01000004_gene339 8.122e-85 293.0 COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,27XEG@189775|Thermomicrobia 189775|Thermomicrobia L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 CMS1_k127_4828990_1 1379698.RBG1_1C00001G0634 1.63e-41 161.0 COG1051@1|root,COG1051@2|Bacteria,2NPZ5@2323|unclassified Bacteria 2|Bacteria F NUDIX domain - - - - - - - - - - - - NUDIX,Nudix_N_2 CMS1_k127_4834910_2 290397.Adeh_3928 2.316e-111 377.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria 1224|Proteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase CMS1_k127_4834910_11 1379281.AVAG01000011_gene1260 1.224e-31 144.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,42MQY@68525|delta/epsilon subdivisions,2WJGJ@28221|Deltaproteobacteria,2M9GQ@213115|Desulfovibrionales 28221|Deltaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C CMS1_k127_4834910_13 747365.Thena_0494 7.505e-23 115.0 COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42EUF@68295|Thermoanaerobacterales 186801|Clostridia C PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N CMS1_k127_4834910_14 469378.Ccur_08380 1.902e-12 79.0 COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,2IJIZ@201174|Actinobacteria,4CV3C@84998|Coriobacteriia 84998|Coriobacteriia C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,POR CMS1_k127_4834910_10 1340493.JNIF01000003_gene2875 3.629e-32 141.0 COG1477@1|root,COG1477@2|Bacteria,3Y4B0@57723|Acidobacteria 57723|Acidobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE CMS1_k127_4834910_0 765912.Thimo_0234 1.362e-134 460.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWWZ@135613|Chromatiales 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,Fer4_7,Fer4_8,RnfC_N,SLBB CMS1_k127_4834910_4 765912.Thimo_0233 5.655e-88 320.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1T20Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347,ko:K03614 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE CMS1_k127_4834910_8 765912.Thimo_0232 3.852e-42 176.0 COG4659@1|root,COG4659@2|Bacteria,1R98X@1224|Proteobacteria 1224|Proteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind CMS1_k127_4834910_5 765912.Thimo_0231 1.094e-73 255.0 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1WW5Q@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr CMS1_k127_4834910_7 765912.Thimo_0230 1.823e-70 251.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1WX8K@135613|Chromatiales 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr CMS1_k127_4834910_3 765912.Thimo_0229 1.624e-97 326.0 COG1142@1|root,COG2878@1|root,COG1142@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales 135613|Chromatiales C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 CMS1_k127_4834910_1 670487.Ocepr_1225 3.85e-112 388.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1WIAF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C COGs COG0674 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase alpha subunit - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N CMS1_k127_4834910_6 1521187.JPIM01000004_gene3035 2.724e-71 270.0 COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi,374ZH@32061|Chloroflexia 32061|Chloroflexia C PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C CMS1_k127_4834910_9 886293.Sinac_6723 3.768e-40 160.0 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - - - - - - - - - - - ICMT,PEMT CMS1_k127_4834910_12 861299.J421_0797 3.666e-27 122.0 COG0671@1|root,COG0671@2|Bacteria 2|Bacteria I phosphatidate phosphatase activity dgkA - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K00901,ko:K01096,ko:K19302 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02029,R02240,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_2369 DAGK_prokar,PAP2,PAP2_3 CMS1_k127_4838163_2 231434.JQJH01000010_gene848 1.965e-24 114.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,3NA6T@45404|Beijerinckiaceae 28211|Alphaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc CMS1_k127_4838163_0 1255043.TVNIR_3806 5.228e-81 289.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1WW01@135613|Chromatiales 135613|Chromatiales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N CMS1_k127_4838163_3 706587.Desti_3938 1.21e-15 87.0 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QPK@68525|delta/epsilon subdivisions,2WN58@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Single-stranded nucleic acid binding R3H - - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H CMS1_k127_4838163_1 1167006.UWK_01749 1.264e-68 251.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MJ96@213118|Desulfobacterales 28221|Deltaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas CMS1_k127_4852403_3 671143.DAMO_2896 9.537e-47 177.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria 2|Bacteria L UvrD/REP helicase N-terminal domain - - 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C CMS1_k127_4852403_1 861299.J421_6105 6.517e-75 277.0 COG0308@1|root,COG0739@1|root,COG0308@2|Bacteria,COG0739@2|Bacteria 2|Bacteria M heme binding - - - ko:K08642,ko:K21472 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Cu_amine_oxidN1,Peptidase_M1,Peptidase_M23 CMS1_k127_4852403_4 84531.JMTZ01000033_gene261 1.597e-30 141.0 COG2207@1|root,COG2207@2|Bacteria,1MZEA@1224|Proteobacteria 1224|Proteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 CMS1_k127_4852403_2 443143.GM18_4316 3.879e-57 222.0 COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Belongs to the peptidase S8 family - - 3.4.21.66 ko:K08651 - - - - ko00000,ko01000,ko01002,ko03110 - - - Big_2,CUB,He_PIG,Peptidase_S8 CMS1_k127_4852403_5 880073.Calab_2082 6.515e-12 79.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF11,DUF4114,DUF4157 CMS1_k127_4852403_0 204669.Acid345_1455 7.95e-129 441.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia 204432|Acidobacteriia KLT Tetratricopeptide repeats - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C CMS1_k127_4856015_6 502025.Hoch_3635 2.068e-30 126.0 COG2259@1|root,COG2259@2|Bacteria,1RDWQ@1224|Proteobacteria,43B87@68525|delta/epsilon subdivisions,2X6MK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX CMS1_k127_4856015_3 1379698.RBG1_1C00001G1903 5.409e-42 174.0 COG2258@1|root,COG2258@2|Bacteria,2NQ3U@2323|unclassified Bacteria 2|Bacteria H Mo-molybdopterin cofactor biosynthetic process mog - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - iAF987.Gmet_0302 MOSC,MoCF_biosynth CMS1_k127_4856015_2 1379698.RBG1_1C00001G1904 1.301e-66 242.0 COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria 2|Bacteria H MoeA N-terminal region (domain I and II) moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N CMS1_k127_4856015_4 1379698.RBG1_1C00001G0910 3.774e-37 160.0 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_4856015_1 1379698.RBG1_1C00001G0911 3.816e-77 271.0 COG0315@1|root,COG0521@1|root,COG0315@2|Bacteria,COG0521@2|Bacteria,2NPNE@2323|unclassified Bacteria 2|Bacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 2.8.1.12,4.6.1.17 ko:K03635,ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395,R11372 RC02507,RC03425 ko00000,ko00001,ko01000 - - - MOSC,MoCF_biosynth,MoaC CMS1_k127_4856015_0 1379698.RBG1_1C00001G0002 6.059e-96 325.0 COG2896@1|root,COG2896@2|Bacteria,2NP5R@2323|unclassified Bacteria 2|Bacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM CMS1_k127_4856015_5 316067.Geob_0102 9.261e-31 129.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,42SCH@68525|delta/epsilon subdivisions,2WPMA@28221|Deltaproteobacteria,43SR2@69541|Desulfuromonadales 28221|Deltaproteobacteria S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 CMS1_k127_4856015_7 862908.BMS_2855 7.154e-10 62.0 COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,43BHQ@68525|delta/epsilon subdivisions,2MTVP@213481|Bdellovibrionales,2X6W7@28221|Deltaproteobacteria 213481|Bdellovibrionales O XdhC Rossmann domain pcmU - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI CMS1_k127_4858931_2 1049564.TevJSym_ax00260 1.121e-32 138.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,1S69P@1236|Gammaproteobacteria 1236|Gammaproteobacteria K crp fnr family - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding CMS1_k127_4858931_1 404589.Anae109_1554 2.44e-45 173.0 COG1595@1|root,COG1595@2|Bacteria,1RI7C@1224|Proteobacteria,42XJU@68525|delta/epsilon subdivisions,2WT13@28221|Deltaproteobacteria,2Z11E@29|Myxococcales 28221|Deltaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4858931_5 543632.JOJL01000064_gene1471 2.204e-07 58.0 COG5660@1|root,COG5660@2|Bacteria,2GQSP@201174|Actinobacteria 201174|Actinobacteria S Putative zinc-finger - - - - - - - - - - - - zf-HC2 CMS1_k127_4858931_4 1521187.JPIM01000037_gene3874 1.565e-09 67.0 COG4454@1|root,COG4454@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Cupredoxin_1 CMS1_k127_4858931_0 1157490.EL26_03540 2.488e-98 336.0 COG3424@1|root,COG3424@2|Bacteria,1TPUK@1239|Firmicutes,4HBHH@91061|Bacilli,278WK@186823|Alicyclobacillaceae 91061|Bacilli Q Chalcone and stilbene synthases, N-terminal domain bcsA - - ko:K16167 - - - - ko00000,ko01008 - - - Chal_sti_synt_C,Chal_sti_synt_N CMS1_k127_4858931_3 665571.STHERM_c21790 5.958e-21 94.0 COG0560@1|root,COG0560@2|Bacteria,2J5Q7@203691|Spirochaetes 203691|Spirochaetes E phosphoserine phosphatase homoserine phosphotransferase bifunctional protein thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase CMS1_k127_4863005_0 1499967.BAYZ01000181_gene4487 1.561e-41 162.0 COG0646@1|root,COG0646@2|Bacteria,2NP9A@2323|unclassified Bacteria 2|Bacteria E Homocysteine S-methyltransferase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - S-methyl_trans CMS1_k127_4863005_2 944564.HMPREF9200_0796 8.846e-12 78.0 COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,4H3ZU@909932|Negativicutes 909932|Negativicutes E Vitamin B12 dependent methionine synthase activation - - - - - - - - - - - - Met_synt_B12 CMS1_k127_4863005_1 368408.Tpen_1467 2.813e-27 117.0 COG5598@1|root,arCOG03405@2157|Archaea 2157|Archaea H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB CMS1_k127_4864027_0 671143.DAMO_1213 5.596e-91 317.0 COG0621@1|root,COG0621@2|Bacteria,2NP2U@2323|unclassified Bacteria 2|Bacteria J Uncharacterized protein family UPF0004 yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 CMS1_k127_4864027_1 59374.Fisuc_0749 6.297e-35 138.0 COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria 2|Bacteria K obsolete transcription factor activity, core RNA polymerase II binding rpsA GO:0005575,GO:0005576,GO:0018995,GO:0020003,GO:0030430,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0065010 1.17.7.4,2.7.11.1 ko:K02945,ko:K03527,ko:K12132 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko01001,ko03011 - - - S1 CMS1_k127_4871254_3 1121468.AUBR01000064_gene937 7.146e-06 49.0 COG1801@1|root,COG1801@2|Bacteria,1TPX4@1239|Firmicutes,24F1Y@186801|Clostridia,42G35@68295|Thermoanaerobacterales 186801|Clostridia S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 CMS1_k127_4871254_0 1128421.JAGA01000002_gene1541 4.422e-190 623.0 COG1205@1|root,COG1205@2|Bacteria,2NNKJ@2323|unclassified Bacteria 2|Bacteria L Domain of unknown function (DUF1998) yprA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C CMS1_k127_4871254_2 456442.Mboo_0279 2.134e-36 152.0 COG3359@1|root,arCOG03130@2157|Archaea,2Y6XZ@28890|Euryarchaeota,2NARC@224756|Methanomicrobia 224756|Methanomicrobia L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 CMS1_k127_4871254_1 1173027.Mic7113_3868 4.105e-40 162.0 COG1670@1|root,COG1670@2|Bacteria,1G6CN@1117|Cyanobacteria,1HDSF@1150|Oscillatoriales 1117|Cyanobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 CMS1_k127_487327_0 861299.J421_3563 5.034e-160 521.0 COG0317@1|root,COG0317@2|Bacteria,1ZT5M@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS CMS1_k127_487327_3 292459.STH2430 6.863e-39 165.0 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia 186801|Clostridia J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase CMS1_k127_487327_2 404380.Gbem_2708 2.738e-44 172.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2WP65@28221|Deltaproteobacteria,43UWG@69541|Desulfuromonadales 28221|Deltaproteobacteria D PFAM Maf family protein maf - - ko:K06287 - - - - ko00000 - - - Maf CMS1_k127_487327_1 644966.Tmar_2110 5.188e-83 290.0 COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia,3WCG0@538999|Clostridiales incertae sedis 186801|Clostridia J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B CMS1_k127_4879120_2 497965.Cyan7822_0706 1.116e-44 170.0 COG3963@1|root,COG3963@2|Bacteria,1GA3R@1117|Cyanobacteria 1117|Cyanobacteria I Methyltransferase FkbM family - - - - - - - - - - - - Methyltransf_21 CMS1_k127_4879120_1 1123242.JH636434_gene5626 5.218e-65 237.0 COG4886@1|root,COG5426@1|root,COG4886@2|Bacteria,COG5426@2|Bacteria 2|Bacteria D von Willebrand factor, type A - - - - - - - - - - - - DUF285,Flg_new,LRR_5,LRR_6 CMS1_k127_4879120_0 861299.J421_1883 1.094e-66 233.0 COG1595@1|root,COG1595@2|Bacteria,1ZV3I@142182|Gemmatimonadetes 2|Bacteria K Sigma-70, region 4 sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4879120_4 402777.KB235904_gene3527 5.64e-09 65.0 COG0251@1|root,COG1357@1|root,COG0251@2|Bacteria,COG1357@2|Bacteria,1G6TD@1117|Cyanobacteria,1H9XQ@1150|Oscillatoriales 1117|Cyanobacteria J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Pentapeptide,Ribonuc_L-PSP CMS1_k127_4886270_4 1173028.ANKO01000094_gene2620 3.188e-05 47.0 COG5316@1|root,COG5316@2|Bacteria,1GD0X@1117|Cyanobacteria,1HESQ@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS1_k127_4886270_0 880073.Calab_3212 3.366e-262 827.0 COG0556@1|root,COG0556@2|Bacteria,2NNPM@2323|unclassified Bacteria 2|Bacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006950,GO:0008150,GO:0009314,GO:0009380,GO:0009605,GO:0009607,GO:0009628,GO:0016020,GO:0032991,GO:0035821,GO:0042802,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB CMS1_k127_4886270_1 1163407.UU7_10182 3.433e-69 246.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1X36W@135614|Xanthomonadales 135614|Xanthomonadales H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N CMS1_k127_4886270_3 309807.SRU_0529 6.281e-38 154.0 COG0340@1|root,COG0340@2|Bacteria,4NHCH@976|Bacteroidetes,1FJI1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Biotin protein ligase C terminal domain birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_LplA_LipB CMS1_k127_4886270_2 293826.Amet_2868 2.235e-50 194.0 COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,36HY1@31979|Clostridiaceae 186801|Clostridia K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone CMS1_k127_4886270_5 706587.Desti_4189 8.184e-05 52.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2MQFF@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC CMS1_k127_4886582_7 909663.KI867150_gene1296 1.798e-15 76.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MQ8F@213462|Syntrophobacterales 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 CMS1_k127_4886582_6 1193181.BN10_840026 5.767e-16 78.0 COG0267@1|root,COG0267@2|Bacteria,2GQFG@201174|Actinobacteria,4FHNB@85021|Intrasporangiaceae 201174|Actinobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 CMS1_k127_4886582_8 1009370.ALO_09022 5.665e-07 55.0 COG0690@1|root,COG0690@2|Bacteria,1VK48@1239|Firmicutes,4H5Y7@909932|Negativicutes 909932|Negativicutes U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE CMS1_k127_4886582_3 518766.Rmar_1103 2.579e-51 191.0 COG0250@1|root,COG0250@2|Bacteria,4NF2X@976|Bacteroidetes,1FJ6G@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG CMS1_k127_4886582_2 1540257.JQMW01000011_gene2082 1.022e-59 211.0 COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,36I00@31979|Clostridiaceae 186801|Clostridia J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N CMS1_k127_4886582_0 1122216.AUHW01000005_gene453 1.141e-88 301.0 COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,4H228@909932|Negativicutes 909932|Negativicutes J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 CMS1_k127_4886582_5 370438.PTH_0308 4.031e-40 164.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,261MK@186807|Peptococcaceae 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 CMS1_k127_4886582_4 635013.TherJR_0286 5.867e-43 161.0 COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,26263@186807|Peptococcaceae 186801|Clostridia J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N CMS1_k127_4886582_1 1379270.AUXF01000004_gene3047 4.28e-81 276.0 COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 CMS1_k127_4892408_5 272560.BPSS0275 1.399e-80 280.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1JZZQ@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the thiolase family pcaF - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_4892408_1 1121918.ARWE01000001_gene2377 5.997e-185 599.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_4892408_4 1121918.ARWE01000001_gene2378 1.95e-92 322.0 COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,42PZY@68525|delta/epsilon subdivisions,2WJ9V@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Acyl CoA acetate 3-ketoacid CoA transferase beta subunit - - 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans CMS1_k127_4892408_3 28229.ND2E_2482 1.394e-104 345.0 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria,2Q5N9@267889|Colwelliaceae 1236|Gammaproteobacteria I 3-oxoacid CoA-transferase pcaI - 2.8.3.5,2.8.3.6 ko:K01027,ko:K01028,ko:K01031 ko00072,ko00280,ko00362,ko00650,ko01100,ko01120,map00072,map00280,map00362,map00650,map01100,map01120 - R00410,R02990 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans CMS1_k127_4892408_0 458817.Shal_2954 3.537e-234 735.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RRI0@1236|Gammaproteobacteria,2QBHP@267890|Shewanellaceae 1236|Gammaproteobacteria E lysine 2,3-aminomutase - - - - - - - - - - - - Fer4_14 CMS1_k127_4892408_2 290397.Adeh_1209 3.935e-145 496.0 COG0457@1|root,COG4262@1|root,COG0457@2|Bacteria,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,42Q43@68525|delta/epsilon subdivisions,2WKQF@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth CMS1_k127_4892408_6 649639.Bcell_3975 3.219e-58 214.0 COG2162@1|root,COG2162@2|Bacteria,1VR6B@1239|Firmicutes,4HTTU@91061|Bacilli,1ZG4J@1386|Bacillus 91061|Bacilli Q N-acetyltransferase - - - - - - - - - - - - Acetyltransf_2 CMS1_k127_4892408_7 926550.CLDAP_32730 0.0002075 48.0 COG5598@1|root,COG5598@2|Bacteria 2|Bacteria H trimethylamine methyltransferase - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB CMS1_k127_4896255_12 181119.XP_005519663.1 1.522e-06 51.0 COG2723@1|root,KOG0626@2759|Eukaryota,38CCU@33154|Opisthokonta,3BCXZ@33208|Metazoa,3CT1M@33213|Bilateria,484XA@7711|Chordata,48ZDY@7742|Vertebrata,4GIAK@8782|Aves 33208|Metazoa G Glycosyl hydrolase family 1 LCT GO:0000016,GO:0001666,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005903,GO:0006950,GO:0007584,GO:0007586,GO:0008150,GO:0008152,GO:0008422,GO:0009605,GO:0009628,GO:0009636,GO:0009719,GO:0009725,GO:0009743,GO:0009744,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010039,GO:0010040,GO:0010045,GO:0010288,GO:0015926,GO:0016020,GO:0016021,GO:0016324,GO:0016740,GO:0016787,GO:0016798,GO:0031224,GO:0031226,GO:0031667,GO:0032501,GO:0034285,GO:0036293,GO:0042221,GO:0042493,GO:0042594,GO:0043627,GO:0044245,GO:0044425,GO:0044459,GO:0044464,GO:0045177,GO:0045471,GO:0046677,GO:0050896,GO:0070482,GO:0071704,GO:0071944,GO:0097305,GO:0098590,GO:0098862,GO:1901135,GO:1901657,GO:1901700 3.2.1.108,3.2.1.21,3.2.1.62 ko:K01229,ko:K05350 ko00052,ko00460,ko00500,ko00940,ko01100,ko01110,ko04973,map00052,map00460,map00500,map00940,map01100,map01110,map04973 - R00026,R01678,R02558,R02887,R02985,R03527,R04949,R04998,R06114,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000,ko03110 - - - Glyco_hydro_1 CMS1_k127_4896255_11 909663.KI867149_gene3355 5.48e-07 58.0 COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,42Y44@68525|delta/epsilon subdivisions,2X6IP@28221|Deltaproteobacteria,2MRQW@213462|Syntrophobacterales 28221|Deltaproteobacteria M Membrane - - - - - - - - - - - - - CMS1_k127_4896255_5 1379698.RBG1_1C00001G0420 4.996e-65 237.0 COG0671@1|root,COG0671@2|Bacteria,2NQMG@2323|unclassified Bacteria 2|Bacteria I Phosphoesterase, PA-phosphatase related protein - - - - - - - - - - - - PAP2,PAP2_3 CMS1_k127_4896255_1 1382356.JQMP01000003_gene1584 4.05e-219 701.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia 189775|Thermomicrobia C Succinyl-CoA ligase like flavodoxin domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig CMS1_k127_4896255_9 644966.Tmar_1440 4.908e-25 107.0 COG2154@1|root,COG2154@2|Bacteria,1VERE@1239|Firmicutes,24NE1@186801|Clostridia 186801|Clostridia H Pterin 4 alpha carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a CMS1_k127_4896255_10 591019.Shell_1090 9.106e-12 69.0 COG2151@1|root,arCOG01845@2157|Archaea,2XQXH@28889|Crenarchaeota 28889|Crenarchaeota S metal-sulfur cluster biosynthetic - - - - - - - - - - - - FeS_assembly_P CMS1_k127_4896255_8 886293.Sinac_5289 2.323e-26 117.0 COG2146@1|root,COG2146@2|Bacteria,2J13Z@203682|Planctomycetes 203682|Planctomycetes C of nitrite reductase and ring-hydroxylating - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske CMS1_k127_4896255_6 525904.Tter_1695 3.641e-49 179.0 COG0822@1|root,COG0822@2|Bacteria,2NPXN@2323|unclassified Bacteria 2|Bacteria C NifU-like N terminal domain nifU - - ko:K04488 - - - - ko00000 - - - NifU_N CMS1_k127_4896255_2 324602.Caur_3483 1.011e-158 510.0 COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi,3766K@32061|Chloroflexia 32061|Chloroflexia E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 CMS1_k127_4896255_4 309801.trd_0379 8.963e-101 345.0 COG0719@1|root,COG0719@2|Bacteria,2G5S8@200795|Chloroflexi,27Y27@189775|Thermomicrobia 189775|Thermomicrobia O Uncharacterized protein family (UPF0051) - - - ko:K09015 - - - - ko00000 - - - UPF0051 CMS1_k127_4896255_0 525904.Tter_1698 3.028e-237 741.0 COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria 2|Bacteria O FeS assembly protein SufB sufB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - ko:K07033,ko:K09014 - - - - ko00000 - - - UPF0051 CMS1_k127_4896255_3 926569.ANT_17980 2.161e-109 359.0 COG0396@1|root,COG0396@2|Bacteria,2G5S6@200795|Chloroflexi 200795|Chloroflexi O PFAM ABC transporter related sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran CMS1_k127_4896255_7 661478.OP10G_0555 2.479e-27 113.0 COG0316@1|root,COG0316@2|Bacteria 2|Bacteria S protein maturation ycf57 GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:1901564 - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn CMS1_k127_4901522_1 1396141.BATP01000003_gene5047 2.883e-143 490.0 COG0612@1|root,COG0612@2|Bacteria,46S9I@74201|Verrucomicrobia,2ITJG@203494|Verrucomicrobiae 74201|Verrucomicrobia S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_4901522_2 644282.Deba_0611 1.198e-96 331.0 COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,42P3H@68525|delta/epsilon subdivisions,2WK0J@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_4901522_0 1209989.TepiRe1_1817 1.718e-144 473.0 COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,42ETH@68295|Thermoanaerobacterales 186801|Clostridia J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c CMS1_k127_490663_0 1519464.HY22_09075 1.008e-32 145.0 COG0642@1|root,COG2205@2|Bacteria 1519464.HY22_09075|- T PhoQ Sensor - - - - - - - - - - - - - CMS1_k127_4914690_7 557599.MKAN_03805 2.964e-25 105.0 COG2030@1|root,COG2030@2|Bacteria,2IK2Z@201174|Actinobacteria,23BIY@1762|Mycobacteriaceae 201174|Actinobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas CMS1_k127_4914690_9 1121374.KB891586_gene2721 1.32e-10 70.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_4914690_11 1123508.JH636443_gene4760 0.0002561 53.0 2DCDW@1|root,2ZDSQ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_4914690_4 929556.Solca_2518 1.659e-53 198.0 2CMS6@1|root,32SFE@2|Bacteria,4NWI0@976|Bacteroidetes,1IYER@117747|Sphingobacteriia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_4914690_5 349521.HCH_04390 1.181e-51 196.0 COG1670@1|root,COG1670@2|Bacteria,1N18Y@1224|Proteobacteria,1S8ZQ@1236|Gammaproteobacteria,1XQ7C@135619|Oceanospirillales 135619|Oceanospirillales J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 CMS1_k127_4914690_2 443143.GM18_3259 8.045e-73 260.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco CMS1_k127_4914690_3 234267.Acid_2488 8.953e-70 254.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Methyltransf_25 CMS1_k127_4914690_8 880073.Calab_2038 1.497e-15 80.0 2DEXR@1|root,2ZPPS@2|Bacteria,2NRXB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_4914690_6 525904.Tter_0136 9.501e-27 125.0 COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria 2|Bacteria U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS1_k127_4914690_0 1254432.SCE1572_02795 3.104e-127 425.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS1_k127_4914690_1 204669.Acid345_1052 6.814e-118 409.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia 204432|Acidobacteriia KLT Tetratricopeptide repeats - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C CMS1_k127_4914690_10 1121324.CLIT_2c03230 3.394e-06 49.0 COG2998@1|root,COG2998@2|Bacteria,1V9V8@1239|Firmicutes,25H3U@186801|Clostridia 186801|Clostridia H Copper amine oxidase N-terminal domain - - - - - - - - - - - - Cu_amine_oxidN1 CMS1_k127_4925127_0 671143.DAMO_2848 9.875e-201 646.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2NNX4@2323|unclassified Bacteria 2|Bacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO CMS1_k127_4925778_1 316278.SynRCC307_0260 6.535e-80 293.0 COG1807@1|root,COG1807@2|Bacteria,1GCHJ@1117|Cyanobacteria,1GZTK@1129|Synechococcus 1117|Cyanobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 CMS1_k127_4925778_0 1089551.KE386572_gene2233 1.383e-82 281.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,4BSGF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 CMS1_k127_4926448_0 266117.Rxyl_2946 2.444e-132 446.0 COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4CPZ0@84995|Rubrobacteria 84995|Rubrobacteria T Transcriptional regulator - - - - - - - - - - - - BTAD,Trans_reg_C CMS1_k127_4926448_1 794903.OPIT5_16405 4.078e-60 218.0 COG1272@1|root,COG1272@2|Bacteria,46T25@74201|Verrucomicrobia,3K7KU@414999|Opitutae 414999|Opitutae S Haemolysin-III related - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII CMS1_k127_4926448_2 552811.Dehly_0286 3.706e-45 166.0 COG2309@1|root,COG2309@2|Bacteria,2G5TH@200795|Chloroflexi,34CT4@301297|Dehalococcoidia 301297|Dehalococcoidia E Thermophilic metalloprotease (M29) - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 CMS1_k127_4943373_1 665571.STHERM_c21790 4.237e-29 121.0 COG0560@1|root,COG0560@2|Bacteria,2J5Q7@203691|Spirochaetes 203691|Spirochaetes E phosphoserine phosphatase homoserine phosphotransferase bifunctional protein thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase CMS1_k127_4943373_0 1123251.ATWM01000007_gene2308 2.031e-130 430.0 COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4FE3G@85021|Intrasporangiaceae 201174|Actinobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt CMS1_k127_4943373_2 38833.XP_003064514.1 7.818e-05 50.0 COG0019@1|root,KOG0622@2759|Eukaryota,37Q1G@33090|Viridiplantae,34JJT@3041|Chlorophyta 3041|Chlorophyta E Belongs to the Orn Lys Arg decarboxylase class-II family - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC CMS1_k127_4947647_11 1380394.JADL01000003_gene4774 0.0004591 45.0 COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,2TRJZ@28211|Alphaproteobacteria,2JWJI@204441|Rhodospirillales 28211|Alphaproteobacteria S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028 CMS1_k127_4947647_10 497964.CfE428DRAFT_1635 1.186e-11 75.0 COG3342@1|root,COG3342@2|Bacteria 2|Bacteria S Family of unknown function (DUF1028) fimA - - - - - - - - - - - DUF1028,PG_binding_2 CMS1_k127_4947647_3 552811.Dehly_0442 3.893e-58 220.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Cytochrom_c3_2 CMS1_k127_4947647_5 240015.ACP_0479 7.38e-40 164.0 COG3005@1|root,COG3005@2|Bacteria,3Y4BJ@57723|Acidobacteria,2JJ2B@204432|Acidobacteriia 204432|Acidobacteriia C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_4947647_2 1245469.S58_72740 1.479e-64 231.0 COG1805@1|root,COG1805@2|Bacteria,1R88C@1224|Proteobacteria,2U32T@28211|Alphaproteobacteria,3JWA7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria U Belongs to the NqrB RnfD family - - - - - - - - - - - - NQR2_RnfD_RnfE CMS1_k127_4947647_1 330214.NIDE1172 1.313e-172 552.0 COG1805@1|root,COG4402@1|root,COG1805@2|Bacteria,COG4402@2|Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2330) nqrB GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 ko:K00347,ko:K21163 ko01059,ko01130,map01059,map01130 M00824 - - ko00000,ko00001,ko00002,ko01000 - - - DUF2330,NQR2_RnfD_RnfE CMS1_k127_4947647_7 646529.Desaci_0681 9.906e-20 97.0 COG2020@1|root,COG2020@2|Bacteria,1VKIT@1239|Firmicutes 1239|Firmicutes O PFAM Isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - ICMT,PEMT CMS1_k127_4947647_9 755732.Fluta_0614 6.545e-12 78.0 2DQEZ@1|root,336F0@2|Bacteria,4NUK8@976|Bacteroidetes,1I4H2@117743|Flavobacteriia,2PBW4@246874|Cryomorphaceae 976|Bacteroidetes S Reeler domain - - - - - - - - - - - - Reeler CMS1_k127_4947647_0 335543.Sfum_0929 2.756e-300 955.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MQUW@213462|Syntrophobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon CMS1_k127_4947647_8 349163.Acry_2844 1.044e-17 96.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,2JQNT@204441|Rhodospirillales 204441|Rhodospirillales L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C CMS1_k127_4947647_4 1379698.RBG1_1C00001G0328 5.052e-51 188.0 2C7E0@1|root,330TX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_4947647_6 1123368.AUIS01000003_gene1747 1.436e-34 136.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,2NCNH@225057|Acidithiobacillales 225057|Acidithiobacillales K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 CMS1_k127_4948086_4 880073.Calab_0041 2.326e-06 51.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase CMS1_k127_4948086_3 290397.Adeh_2884 7.149e-79 293.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42SJR@68525|delta/epsilon subdivisions,2WRRB@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_4948086_2 379066.GAU_3326 1.76e-128 424.0 COG2081@1|root,COG2081@2|Bacteria,1ZUAT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like CMS1_k127_4948086_0 700598.Niako_0029 2.164e-206 657.0 COG1032@1|root,COG1032@2|Bacteria,4PHMM@976|Bacteroidetes,1IWI2@117747|Sphingobacteriia 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - Radical_SAM CMS1_k127_4948086_1 269797.Mbar_A1244 5.195e-157 510.0 COG0520@1|root,arCOG00065@2157|Archaea 2157|Archaea E COG0520 Selenocysteine lyase - - - - - - - - - - - - Aminotran_5 CMS1_k127_4951827_4 1122947.FR7_4390 5.197e-21 103.0 COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1TS3B@1239|Firmicutes,4H88H@909932|Negativicutes 909932|Negativicutes T PFAM protein phosphatase 2C domain protein, response regulator receiver - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - Response_reg,SpoIIE CMS1_k127_4951827_2 459349.CLOAM1198 1.273e-44 180.0 2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - CMS1_k127_4951827_1 1379698.RBG1_1C00001G0113 1.78e-55 205.0 28MYQ@1|root,2ZB5K@2|Bacteria,2NPC8@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - CMS1_k127_4951827_3 330214.NIDE2490 7.652e-39 156.0 29ZH8@1|root,30MGZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_4951827_0 1379698.RBG1_1C00001G0119 9.376e-90 302.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - CMS1_k127_4954887_1 1232437.KL662006_gene4384 2.822e-46 169.0 2E9PG@1|root,333VW@2|Bacteria,1NEU7@1224|Proteobacteria,42ZPQ@68525|delta/epsilon subdivisions,2WV1S@28221|Deltaproteobacteria,2MNDN@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_4954887_2 56107.Cylst_2378 0.0002964 44.0 COG2931@1|root,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria,1HIHD@1161|Nostocales 1117|Cyanobacteria Q Hemolysin-type calcium-binding repeat (2 copies) - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - Cadherin,Calx-beta,DUF4347,HemolysinCabind,Lectin_C CMS1_k127_4954887_0 296591.Bpro_0708 2.298e-76 274.0 COG3447@1|root,COG4585@1|root,COG3447@2|Bacteria,COG4585@2|Bacteria,1PF0H@1224|Proteobacteria,2W8ZC@28216|Betaproteobacteria,4AI7H@80864|Comamonadaceae 28216|Betaproteobacteria T MASE1 - - - - - - - - - - - - HATPase_c,MASE1 CMS1_k127_49607_0 1120972.AUMH01000007_gene1617 2.615e-148 484.0 2CA5R@1|root,2Z81H@2|Bacteria,1UYYB@1239|Firmicutes,4HA7J@91061|Bacilli 91061|Bacilli S Domain of unknown function (DUF4153) - - - - - - - - - - - - DUF4153 CMS1_k127_49607_3 1120972.AUMH01000007_gene1618 1.586e-51 184.0 COG1695@1|root,COG1695@2|Bacteria,1VBBY@1239|Firmicutes 1239|Firmicutes K Transcriptional regulator - - - - - - - - - - - - PadR CMS1_k127_49607_1 1232410.KI421419_gene2503 7.065e-124 403.0 COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,43SFJ@69541|Desulfuromonadales 28221|Deltaproteobacteria C radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Radical_SAM CMS1_k127_49607_4 760568.Desku_2735 6.897e-06 51.0 COG1163@1|root,COG1163@2|Bacteria,1TSAP@1239|Firmicutes,24EEW@186801|Clostridia,260UT@186807|Peptococcaceae 186801|Clostridia S TGS domain - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS CMS1_k127_4997602_1 867845.KI911784_gene3129 6.376e-53 195.0 COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,375CQ@32061|Chloroflexia 32061|Chloroflexia S PFAM Amidohydrolase 3 - - - - - - - - - - - - Amidohydro_3 CMS1_k127_4997602_0 1379698.RBG1_1C00001G1445 6.18e-215 702.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NQSG@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - BSP,Bac_surface_Ag,PD40,Peptidase_MA_2 CMS1_k127_5000782_0 1121288.AULL01000012_gene620 2.532e-48 192.0 COG1073@1|root,COG1073@2|Bacteria,4PMNT@976|Bacteroidetes,1IKPN@117743|Flavobacteriia 976|Bacteroidetes O Belongs to the peptidase S8 family - - - - - - - - - - - - DUF676,PGAP1 CMS1_k127_5018412_4 1254432.SCE1572_25755 1.858e-15 79.0 COG0848@1|root,COG0848@2|Bacteria,1Q1RQ@1224|Proteobacteria,437EZ@68525|delta/epsilon subdivisions,2X2MA@28221|Deltaproteobacteria,2Z03D@29|Myxococcales 28221|Deltaproteobacteria U Biopolymer transport protein - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD CMS1_k127_5018412_3 1192034.CAP_5320 2.366e-42 159.0 COG0848@1|root,COG0848@2|Bacteria,1RDJZ@1224|Proteobacteria,42RJ1@68525|delta/epsilon subdivisions,2X6VG@28221|Deltaproteobacteria,2YVC5@29|Myxococcales 28221|Deltaproteobacteria U Biopolymer transport protein ExbD/TolR - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD CMS1_k127_5018412_1 1144275.COCOR_01348 2.275e-80 275.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2YVCD@29|Myxococcales 28221|Deltaproteobacteria U MotA TolQ ExbB proton channel tolQ - - ko:K03561,ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - MotA_ExbB CMS1_k127_5018412_2 246197.MXAN_1449 1.159e-51 191.0 COG0810@1|root,COG0810@2|Bacteria,1NDQZ@1224|Proteobacteria,42VIY@68525|delta/epsilon subdivisions,2X4WH@28221|Deltaproteobacteria,2YZR4@29|Myxococcales 28221|Deltaproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C CMS1_k127_5018412_0 378806.STAUR_2949 3.59e-251 806.0 COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,43BZA@68525|delta/epsilon subdivisions,2X7A1@28221|Deltaproteobacteria,2YU9I@29|Myxococcales 28221|Deltaproteobacteria M TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec CMS1_k127_5037973_0 290397.Adeh_2194 3.814e-205 663.0 COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2WPT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm,ResB CMS1_k127_5037973_1 435591.BDI_2507 3.266e-05 51.0 COG4372@1|root,COG4372@2|Bacteria,4NJGZ@976|Bacteroidetes,2G2H0@200643|Bacteroidia,22WW1@171551|Porphyromonadaceae 976|Bacteroidetes S Transposase - - - - - - - - - - - - - CMS1_k127_5060340_1 575540.Isop_1417 5.637e-17 81.0 COG0173@1|root,COG0173@2|Bacteria,2IX6U@203682|Planctomycetes 203682|Planctomycetes J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon CMS1_k127_5060340_2 519989.ECTPHS_02901 8.047e-10 68.0 COG1652@1|root,COG1652@2|Bacteria 2|Bacteria S positive regulation of growth rate ygaU GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019222,GO:0030955,GO:0031420,GO:0035864,GO:0040008,GO:0040009,GO:0040010,GO:0042221,GO:0043167,GO:0043169,GO:0045927,GO:0046872,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007 - ko:K21687,ko:K21688,ko:K21689,ko:K21690,ko:K21691 - - - - ko00000 - GH23 - LysM,Peptidase_M23,Transglycosylas CMS1_k127_5060340_0 1123405.AUMM01000024_gene2053 1.467e-21 106.0 COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,4HBD5@91061|Bacilli,26P1E@186821|Sporolactobacillaceae 91061|Bacilli T PhoH-like protein phoH - - ko:K06217 - - - - ko00000 - - - PhoH CMS1_k127_5061085_1 1379698.RBG1_1C00001G1003 1.281e-122 412.0 COG0768@1|root,COG0768@2|Bacteria,2NNYI@2323|unclassified Bacteria 2|Bacteria M Penicillin-binding protein 2 mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase CMS1_k127_5061085_5 97138.C820_02272 2.015e-09 70.0 COG2891@1|root,COG2891@2|Bacteria,1V1EJ@1239|Firmicutes,24GF4@186801|Clostridia 186801|Clostridia M rod shape-determining protein MreD mreD - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD CMS1_k127_5061085_2 644966.Tmar_2216 8.881e-31 133.0 COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,3WCMB@538999|Clostridiales incertae sedis 186801|Clostridia M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC CMS1_k127_5061085_0 1379698.RBG1_1C00001G1860 2.07e-146 473.0 COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria 2|Bacteria D MreB/Mbl protein mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl CMS1_k127_5061085_3 566461.SSFG_05221 4.54e-20 103.0 COG0705@1|root,COG0705@2|Bacteria,2GNPK@201174|Actinobacteria 201174|Actinobacteria S PFAM Rhomboid family protein - - - - - - - - - - - - Rhomboid CMS1_k127_5061085_4 682795.AciX8_0803 5.313e-14 75.0 COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia 204432|Acidobacteriia E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_5099021_1 1217720.ALOX01000136_gene3949 1.981e-28 121.0 2DDQ6@1|root,2ZIVX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5108142_2 316067.Geob_1937 3.186e-05 46.0 COG1463@1|root,COG1463@2|Bacteria,1MY8D@1224|Proteobacteria,42TCA@68525|delta/epsilon subdivisions,2WP6I@28221|Deltaproteobacteria,43TRY@69541|Desulfuromonadales 28221|Deltaproteobacteria Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS1_k127_5108142_0 1254432.SCE1572_42010 3.643e-68 245.0 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42TZR@68525|delta/epsilon subdivisions,2WQAW@28221|Deltaproteobacteria,2YV9A@29|Myxococcales 28221|Deltaproteobacteria M NmrA-like family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase CMS1_k127_5108142_1 215803.DB30_0528 5.958e-49 181.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales 28221|Deltaproteobacteria K acetyltransferase - - - - - - - - - - - - - CMS1_k127_511884_0 326427.Cagg_1601 4.649e-40 151.0 COG0123@1|root,COG0123@2|Bacteria,2G89I@200795|Chloroflexi,376ST@32061|Chloroflexia 32061|Chloroflexia BQ PFAM histone deacetylase superfamily - - - - - - - - - - - - Hist_deacetyl CMS1_k127_511884_1 526225.Gobs_3529 4.443e-18 96.0 COG3547@1|root,COG3547@2|Bacteria,2H56K@201174|Actinobacteria,4EXAV@85013|Frankiales 201174|Actinobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 CMS1_k127_5138695_1 1122611.KB903943_gene1618 5.794e-14 85.0 29Z9J@1|root,30M7S@2|Bacteria,2I14U@201174|Actinobacteria,4EKXD@85012|Streptosporangiales 201174|Actinobacteria S Protein of unknown function (DUF3592) - - - - - - - - - - - - DUF3592 CMS1_k127_5138695_0 1278073.MYSTI_04899 1.263e-29 122.0 COG3335@1|root,COG3335@2|Bacteria 2|Bacteria L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_32,HTH_33 CMS1_k127_5144165_0 483219.LILAB_00435 9.681e-118 390.0 COG3385@1|root,COG3385@2|Bacteria,1R55Y@1224|Proteobacteria,437YG@68525|delta/epsilon subdivisions,2X38D@28221|Deltaproteobacteria,2YUTS@29|Myxococcales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 CMS1_k127_515820_0 1419583.V466_21045 3.813e-48 186.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,1RQ4U@1236|Gammaproteobacteria,1YNI1@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria U Belongs to the GSP D family rcpA - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N CMS1_k127_515820_1 247490.KSU1_D0130 4.226e-36 148.0 COG3745@1|root,COG3745@2|Bacteria 2|Bacteria U Flp pilus assembly protein CpaB cpaB - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF CMS1_k127_515820_3 644966.Tmar_1212 5.113e-07 61.0 COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia,3WDPM@538999|Clostridiales incertae sedis 186801|Clostridia U TadE-like protein - - - - - - - - - - - - TadE CMS1_k127_515820_2 883126.HMPREF9710_04621 5.039e-19 95.0 COG1989@1|root,COG1989@2|Bacteria,1R34X@1224|Proteobacteria,2WIFE@28216|Betaproteobacteria,477P5@75682|Oxalobacteraceae 28216|Betaproteobacteria NOU Type IV leader peptidase family - - 3.4.23.43 ko:K02278 - - - - ko00000,ko01000,ko02035,ko02044 - - - Peptidase_A24 CMS1_k127_5191936_12 1121481.AUAS01000002_gene3471 7.072e-11 77.0 COG2931@1|root,COG3210@1|root,COG3391@1|root,COG3409@1|root,COG4625@1|root,COG5184@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG3409@2|Bacteria,COG4625@2|Bacteria,COG5184@2|Bacteria,4PB09@976|Bacteroidetes,47UXI@768503|Cytophagia 976|Bacteroidetes O Bacterial Ig-like domain - - - - - - - - - - - - Big_5,VCBS CMS1_k127_5191936_0 929556.Solca_2367 4.614e-164 561.0 COG2373@1|root,COG2373@2|Bacteria 2|Bacteria U Large extracellular alpha-helical protein - - - - - - - - - - - - CHU_C,Calx-beta,DUF11,HYR,HemolysinCabind,IgGFc_binding CMS1_k127_5191936_11 1519464.HY22_13055 4.078e-11 78.0 COG0265@1|root,COG0366@1|root,COG0265@2|Bacteria,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - Alpha-amylase CMS1_k127_5191936_2 946362.XP_004997743.1 1.209e-137 485.0 COG2132@1|root,2QR4X@2759|Eukaryota,38BK4@33154|Opisthokonta 33154|Opisthokonta Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_5191936_1 228410.NE0794 3.721e-144 469.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VHM2@28216|Betaproteobacteria,371VS@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_5191936_5 1216932.CM240_2392 4.797e-51 196.0 COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,249T1@186801|Clostridia,36HGQ@31979|Clostridiaceae 186801|Clostridia M PFAM Glycosyl transferase family 2 - - - ko:K07011,ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,Methyltransf_23 CMS1_k127_5191936_4 891968.Anamo_1233 8.913e-73 265.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process rfbE - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C CMS1_k127_5191936_10 459349.CLOAM1790 2.037e-12 80.0 COG1572@1|root,COG1572@2|Bacteria,2NRE4@2323|unclassified Bacteria 2|Bacteria K Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - CARDB,Cleaved_Adhesin,FlgD_ig,MAM,VCBS CMS1_k127_5191936_8 83219.PM02_02490 1.839e-15 90.0 COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PKD CMS1_k127_5191936_6 693986.MOC_1548 4.576e-28 117.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBQE@28211|Alphaproteobacteria,1JVT3@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Helix-turn-helix domain - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 CMS1_k127_5191936_3 105420.BBPO01000020_gene5574 4.913e-73 259.0 COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria,2NJAM@228398|Streptacidiphilus 201174|Actinobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate CMS1_k127_5191936_7 1121382.JQKG01000019_gene1276 5.663e-26 120.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - ko:K06889 - - - - ko00000 - - - BAAT_C,Hydrolase_4,Peptidase_S9 CMS1_k127_5191936_9 945713.IALB_1647 9.185e-13 81.0 28KE7@1|root,2ZA0G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5200872_0 497964.CfE428DRAFT_5426 4.413e-106 359.0 COG1680@1|root,COG1680@2|Bacteria,46WGY@74201|Verrucomicrobia 74201|Verrucomicrobia V COG1680 Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - - CMS1_k127_5200872_1 96561.Dole_2317 9.597e-15 78.0 2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,42WYZ@68525|delta/epsilon subdivisions,2WT48@28221|Deltaproteobacteria,2MPCB@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_5200872_3 1121890.AUDO01000007_gene2434 7.869e-05 51.0 2E6ZV@1|root,331IX@2|Bacteria,4NWV5@976|Bacteroidetes,1ID7N@117743|Flavobacteriia,2NXMA@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_5200872_2 1382359.JIAL01000001_gene450 2.005e-10 71.0 COG2948@1|root,COG2948@2|Bacteria,3Y81Q@57723|Acidobacteria,2JN9S@204432|Acidobacteriia 204432|Acidobacteriia U multi-organism process - - - ko:K03195 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - TrbI CMS1_k127_523793_6 1095769.CAHF01000022_gene432 2.794e-130 463.0 COG3209@1|root,COG3209@2|Bacteria,1QJCC@1224|Proteobacteria,2WF53@28216|Betaproteobacteria 28216|Betaproteobacteria M COG3209 Rhs family protein - - - ko:K11021 - - - - ko00000,ko02042 - - - SpvB,TcdB_toxin_midC,TcdB_toxin_midN CMS1_k127_523793_12 290397.Adeh_3209 5.51e-05 49.0 COG2944@1|root,COG2944@2|Bacteria 2|Bacteria K sequence-specific DNA binding higA-2 - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3,HTH_31 CMS1_k127_523793_3 1396418.BATQ01000005_gene1375 3.926e-184 612.0 COG1413@1|root,COG1413@2|Bacteria,46XCN@74201|Verrucomicrobia,2IVG4@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Domain of unknown function (DUF4132) - - - - - - - - - - - - DUF4132 CMS1_k127_523793_9 1403819.BATR01000031_gene961 7.984e-65 251.0 COG4715@1|root,COG4715@2|Bacteria 2|Bacteria S zinc ion binding yehQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM CMS1_k127_523793_7 1396418.BATQ01000005_gene1379 1.845e-124 410.0 COG3552@1|root,COG3552@2|Bacteria 2|Bacteria S VWA domain containing CoxE-like protein yehP - - - - - - - - - - - VWA_CoxE CMS1_k127_523793_4 82654.Pse7367_0501 2.943e-151 523.0 COG2425@1|root,COG2425@2|Bacteria,1GQHF@1117|Cyanobacteria,1HHUY@1150|Oscillatoriales 1117|Cyanobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - - CMS1_k127_523793_5 1403819.BATR01000031_gene964 4.997e-149 488.0 COG0714@1|root,COG0714@2|Bacteria 2|Bacteria KLT Associated with various cellular activities yehL - - - - - - - - - - - AAA_5 CMS1_k127_523793_2 1403819.BATR01000031_gene965 4.546e-201 673.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Cytochrom_C,DUF4132,HEAT_2,cNMP_binding CMS1_k127_523793_11 404589.Anae109_3980 2.146e-40 166.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_5,Phage_integrase CMS1_k127_523793_8 1211777.BN77_p2200003 3.522e-109 376.0 COG0476@1|root,COG0476@2|Bacteria,1NPTG@1224|Proteobacteria,2UNBV@28211|Alphaproteobacteria,4BIPZ@82115|Rhizobiaceae 28211|Alphaproteobacteria H Prokaryotic E2 family C - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Prok-E2_C,ThiF CMS1_k127_523793_1 404589.Anae109_4010 6.682e-256 818.0 COG2887@1|root,COG2887@2|Bacteria,1NH8X@1224|Proteobacteria 1224|Proteobacteria L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 CMS1_k127_523793_0 404589.Anae109_4011 0.0 1052.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJ30@28221|Deltaproteobacteria 28221|Deltaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C CMS1_k127_523793_10 402777.KB235899_gene4871 3.609e-48 188.0 2DM6A@1|root,31WJN@2|Bacteria,1GC51@1117|Cyanobacteria,1HF6K@1150|Oscillatoriales 1117|Cyanobacteria S Uracil DNA glycosylase superfamily - - - - - - - - - - - - UDG CMS1_k127_5279259_0 1125863.JAFN01000001_gene1650 1.138e-130 442.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_5279259_1 404589.Anae109_3408 5.806e-53 196.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2YUYF@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 CMS1_k127_5279304_3 1121403.AUCV01000004_gene2028 7.097e-23 102.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2MIHH@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh CMS1_k127_5279304_2 1121430.JMLG01000006_gene1760 5.53e-46 183.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,261I3@186807|Peptococcaceae 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 CMS1_k127_5279304_4 880073.Calab_3481 3.607e-22 113.0 COG1729@1|root,COG1729@2|Bacteria,2NPUR@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 CMS1_k127_5279304_0 671143.DAMO_2139 6.453e-139 456.0 COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria 2|Bacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 CMS1_k127_5279304_1 485916.Dtox_2355 3.327e-88 297.0 COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,260AV@186807|Peptococcaceae 186801|Clostridia F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS1_k127_5348221_2 555079.Toce_1971 6.44e-13 81.0 COG1664@1|root,COG1664@2|Bacteria,1VBC3@1239|Firmicutes,24NSR@186801|Clostridia,42I1I@68295|Thermoanaerobacterales 186801|Clostridia M Polymer-forming cytoskeletal - - - - - - - - - - - - - CMS1_k127_5348221_3 338969.Rfer_3589 0.0002298 53.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,4AE7P@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 CMS1_k127_5348221_1 880073.Calab_0514 3.488e-19 101.0 COG0729@1|root,COG0729@2|Bacteria 2|Bacteria M surface antigen - - - - - - - - - - - - Bac_surface_Ag,Metallophos,Peptidase_M1 CMS1_k127_5348221_0 1123371.ATXH01000019_gene586 1.185e-53 194.0 COG2204@1|root,COG2204@2|Bacteria,2GH1I@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T Bacterial regulatory protein, Fis family - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_5352519_1 426114.THI_0089 1.046e-20 92.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,1KJMG@119065|unclassified Burkholderiales 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran CMS1_k127_5352519_0 290318.Cvib_1268 4.68e-118 407.0 COG1966@1|root,COG1966@2|Bacteria 2|Bacteria T Carbon starvation protein - - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM CMS1_k127_5352519_2 1169161.KB897724_gene4845 1.514e-11 76.0 COG0183@1|root,COG0183@2|Bacteria,2GJI8@201174|Actinobacteria 201174|Actinobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation fadA2 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_5355307_0 1379698.RBG1_1C00001G1659 3.043e-82 294.0 COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria 2|Bacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 CMS1_k127_5355307_1 1410616.JHXE01000001_gene2468 1.353e-13 84.0 COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,3NHB0@46205|Pseudobutyrivibrio 186801|Clostridia S YbaB/EbfC DNA-binding family - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd CMS1_k127_5355696_2 1303518.CCALI_01109 4.605e-14 73.0 COG0665@1|root,COG0665@2|Bacteria 2|Bacteria E tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO CMS1_k127_5355696_0 344747.PM8797T_00899 2.884e-171 550.0 COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 CMS1_k127_5355696_1 502025.Hoch_4973 9.622e-52 194.0 COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2YUE6@29|Myxococcales 28221|Deltaproteobacteria L Deoxyribodipyrimidine photo-lyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 CMS1_k127_5372391_0 316067.Geob_2780 1.053e-76 266.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,43TBH@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with NAD( ) as electron acceptor pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh CMS1_k127_5372391_1 1111454.HMPREF1250_0237 8.599e-49 194.0 COG0284@1|root,COG0284@2|Bacteria,1TPPH@1239|Firmicutes,4H1VK@909932|Negativicutes 909932|Negativicutes F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase CMS1_k127_5372391_2 1444309.JAQG01000090_gene1270 5.123e-35 141.0 COG1089@1|root,COG1089@2|Bacteria,1UJFF@1239|Firmicutes,4HF5Y@91061|Bacilli,275YJ@186822|Paenibacillaceae 91061|Bacilli M Polysaccharide biosynthesis protein - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd CMS1_k127_538568_0 1254432.SCE1572_17565 3.652e-83 294.0 COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin CMS1_k127_538568_1 1077972.ARGLB_083_00560 7.22e-73 253.0 COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,2GNW2@201174|Actinobacteria,1WADX@1268|Micrococcaceae 201174|Actinobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - AHSA1,HTH_20 CMS1_k127_539378_1 1297742.A176_06263 8.602e-19 93.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,Acetyltransf_9,DUF952 CMS1_k127_539378_3 448385.sce1897 5.646e-09 64.0 2AH4C@1|root,317DX@2|Bacteria,1PYQ3@1224|Proteobacteria,435H7@68525|delta/epsilon subdivisions,2WZUU@28221|Deltaproteobacteria,2Z2SV@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_539378_2 631362.Thi970DRAFT_03186 2.174e-17 94.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,1X0B5@135613|Chromatiales 135613|Chromatiales M Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 CMS1_k127_539378_0 2074.JNYD01000025_gene604 4.801e-74 259.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria,4E0GX@85010|Pseudonocardiales 201174|Actinobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR,POR_N,TPP_enzyme_C CMS1_k127_5394624_3 1500894.JQNN01000001_gene2742 9.068e-83 289.0 COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_5394624_1 204669.Acid345_4390 5.448e-107 381.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia 204432|Acidobacteriia KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_5394624_4 1476876.JOJO01000030_gene3181 2.084e-77 272.0 COG0668@1|root,COG0668@2|Bacteria,2GZI1@201174|Actinobacteria 201174|Actinobacteria M mechanosensitive ion channel - - - - - - - - - - - - MS_channel,cNMP_binding CMS1_k127_5394624_0 1142394.PSMK_05030 1.221e-112 371.0 COG0388@1|root,COG0388@2|Bacteria,2IXDC@203682|Planctomycetes 203682|Planctomycetes K COG0454 Histone acetyltransferase HPA2 and related - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase CMS1_k127_5394624_5 1142394.PSMK_05040 7.833e-46 193.0 COG0388@1|root,COG0388@2|Bacteria,2IXDC@203682|Planctomycetes 203682|Planctomycetes K COG0454 Histone acetyltransferase HPA2 and related - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_5394624_2 1121920.AUAU01000011_gene149 4.187e-90 309.0 COG2270@1|root,COG2270@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K08162,ko:K08226,ko:K16211 - - - - ko00000,ko02000 2.A.1.2.21,2.A.1.41,2.A.2.6 - - MFS_1,PUCC CMS1_k127_5396612_1 880073.Calab_2082 2.884e-20 92.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF11,DUF4114,DUF4157 CMS1_k127_5396612_0 1408433.JHXV01000027_gene3728 5.431e-120 425.0 COG2208@1|root,COG3292@1|root,COG4191@1|root,COG2208@2|Bacteria,COG3292@2|Bacteria,COG4191@2|Bacteria,4NG28@976|Bacteroidetes,1I1IG@117743|Flavobacteriia 976|Bacteroidetes KT regulator - - - - - - - - - - - - GerE,Reg_prop,Y_Y_Y CMS1_k127_5396612_2 459349.CLOAM0430 5.244e-11 69.0 COG2067@1|root,COG2067@2|Bacteria,2NQZT@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - CMS1_k127_5414784_0 665571.STHERM_c01570 1.657e-185 597.0 COG0173@1|root,COG0173@2|Bacteria,2J5KG@203691|Spirochaetes 203691|Spirochaetes J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon CMS1_k127_5422740_0 1192034.CAP_2782 7.877e-196 625.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MCF@68525|delta/epsilon subdivisions,2WJRK@28221|Deltaproteobacteria,2YYUX@29|Myxococcales 28221|Deltaproteobacteria I AMP-binding enzyme C-terminal domain bamY - 6.2.1.25 ko:K04110 ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120 - R01422 RC00004,RC00174 ko00000,ko00001,ko01000 - - iAF987.Gmet_2143 AMP-binding,AMP-binding_C CMS1_k127_5422740_1 595536.ADVE02000001_gene3335 0.000404 47.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2TUFR@28211|Alphaproteobacteria,36XR2@31993|Methylocystaceae 28211|Alphaproteobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS1_k127_5423283_1 59374.Fisuc_0695 1.823e-54 198.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 CMS1_k127_5423283_0 861299.J421_3119 5.434e-87 306.0 COG0438@1|root,COG0438@2|Bacteria,1ZTBC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_543200_1 867903.ThesuDRAFT_00861 4.208e-48 180.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WCSJ@538999|Clostridiales incertae sedis 186801|Clostridia P Carbohydrate ABC transporter ATP-binding protein, CUT1 family - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 CMS1_k127_543200_2 234267.Acid_4188 8.257e-40 165.0 COG1266@1|root,COG1266@2|Bacteria,3Y5CJ@57723|Acidobacteria 57723|Acidobacteria S PFAM Abortive infection protein - - - ko:K07052 - - - - ko00000 - - - Abi CMS1_k127_543200_0 1297742.A176_02680 1.564e-52 208.0 COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria,2YTZI@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the peptidase S8 family - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 CMS1_k127_543200_4 880073.Calab_3071 5.855e-07 63.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - CHU_C,DUF11,Flg_new,SLH CMS1_k127_543200_3 1282360.ABAC460_00655 1.21e-25 121.0 COG0823@1|root,COG0823@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Periplasmic component of the Tol biopolymer transport system tolB2 - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_5433339_0 443143.GM18_0320 5.657e-68 240.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains REC, sigma54 interaction, HTH8 - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_5433339_2 243231.GSU2916 3.034e-43 176.0 COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,42TFH@68525|delta/epsilon subdivisions,2WPEH@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase HAMP - - - - - - - - - - - - HAMP,HATPase_c,HisKA CMS1_k127_5433339_1 1379698.RBG1_1C00001G0456 2.274e-47 192.0 COG0760@1|root,COG0760@2|Bacteria,2NP7B@2323|unclassified Bacteria 2|Bacteria O Peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K01802,ko:K03769,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3 CMS1_k127_5433339_3 324925.Ppha_0702 6.513e-11 66.0 COG1826@1|root,COG1826@2|Bacteria,1FE6Y@1090|Chlorobi 1090|Chlorobi U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 CMS1_k127_5441338_0 379066.GAU_3854 6.1e-57 207.0 COG3174@1|root,COG3174@2|Bacteria,1ZUTX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC CMS1_k127_5441338_2 765869.BDW_09560 9.054e-27 124.0 COG3213@1|root,COG3213@2|Bacteria,1Q61U@1224|Proteobacteria,4328M@68525|delta/epsilon subdivisions,2MUD9@213481|Bdellovibrionales,2WXFV@28221|Deltaproteobacteria 213481|Bdellovibrionales P NnrS protein - - - ko:K07234 - - - - ko00000 - - - NnrS CMS1_k127_5441338_1 768704.Desmer_3453 2.648e-28 122.0 COG1277@1|root,COG1277@2|Bacteria,1UZYB@1239|Firmicutes,24WAQ@186801|Clostridia,263UT@186807|Peptococcaceae 186801|Clostridia S ABC-2 family transporter protein - - - ko:K01992,ko:K19341 ko02010,map02010 M00254,M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 - - ABC2_membrane_2 CMS1_k127_5444208_0 1379698.RBG1_1C00001G1725 0.0 1154.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran CMS1_k127_5447566_1 671143.DAMO_2095 7.057e-122 413.0 COG0744@1|root,COG0744@2|Bacteria,2NNMB@2323|unclassified Bacteria 2|Bacteria M Transglycosylase mrcB - 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H CMS1_k127_5447566_2 477974.Daud_0006 2.444e-46 173.0 COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,261GR@186807|Peptococcaceae 186801|Clostridia F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran CMS1_k127_5447566_0 671143.DAMO_2856 1.942e-152 496.0 COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria 2|Bacteria L DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon CMS1_k127_5452176_2 880073.Calab_1159 1.189e-05 55.0 2A6YD@1|root,30VTC@2|Bacteria,2NQ0X@2323|unclassified Bacteria 2|Bacteria S Yip1 domain - - - - - - - - - - - - Yip1 CMS1_k127_5452176_0 335543.Sfum_3705 2.947e-08 64.0 COG0810@1|root,COG0810@2|Bacteria,1NDQZ@1224|Proteobacteria,42VIY@68525|delta/epsilon subdivisions,2WRTC@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C CMS1_k127_5452176_1 309807.SRU_1679 8.686e-07 56.0 COG0848@1|root,COG0848@2|Bacteria,4NHYQ@976|Bacteroidetes,1FJBN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD CMS1_k127_5456746_3 483219.LILAB_33175 0.0008989 42.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,2Z141@29|Myxococcales 28221|Deltaproteobacteria L transposase mutator type - - - - - - - - - - - - Transposase_mut CMS1_k127_5456746_2 1297742.A176_03026 2.337e-16 84.0 COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,42WWI@68525|delta/epsilon subdivisions,2WSR8@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 CMS1_k127_5456746_0 215803.DB30_4272 2.119e-24 116.0 COG0399@1|root,COG0515@1|root,COG0399@2|Bacteria,COG0515@2|Bacteria,1MUMJ@1224|Proteobacteria,43BZX@68525|delta/epsilon subdivisions,2X7AP@28221|Deltaproteobacteria,2YXNP@29|Myxococcales 28221|Deltaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp CMS1_k127_546024_1 671143.DAMO_1538 2.022e-15 79.0 COG0668@1|root,COG0668@2|Bacteria,2NQ6B@2323|unclassified Bacteria 2|Bacteria M transmembrane transport cmpX - - - - - - - - - - - MS_channel,TM_helix CMS1_k127_546024_0 671143.DAMO_1541 1.399e-150 486.0 COG1215@1|root,COG1215@2|Bacteria,2NNSB@2323|unclassified Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups gpgS - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - CMS1_k127_5460262_4 1235800.C819_00719 6.258e-18 87.0 COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,25E75@186801|Clostridia,27NJG@186928|unclassified Lachnospiraceae 186801|Clostridia L D12 class N6 adenine-specific DNA methyltransferase dam - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 CMS1_k127_5460262_1 794903.OPIT5_22745 1.316e-68 260.0 COG2514@1|root,COG2514@2|Bacteria,46SQP@74201|Verrucomicrobia,3K9FN@414999|Opitutae 414999|Opitutae S Glyoxalase-like domain - - 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase CMS1_k127_5460262_0 1121957.ATVL01000008_gene4145 2.112e-88 310.0 COG2357@1|root,COG2357@2|Bacteria,4NFMF@976|Bacteroidetes,47P2Z@768503|Cytophagia 976|Bacteroidetes S RelA SpoT domain protein - - - - - - - - - - - - GTA_TIM CMS1_k127_5460262_3 1232410.KI421415_gene2932 5.694e-33 133.0 COG2138@1|root,COG2138@2|Bacteria 2|Bacteria S sirohydrochlorin cobaltochelatase activity cbiX - 4.99.1.3,4.99.1.4 ko:K03794,ko:K03795 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R05807 RC01012 ko00000,ko00001,ko00002,ko01000 - - - CbiX CMS1_k127_5460262_2 519442.Huta_1731 1.181e-40 166.0 COG1397@1|root,arCOG04448@2157|Archaea,2XV15@28890|Euryarchaeota,23TFB@183963|Halobacteria 183963|Halobacteria O ADP-ribosyl-(Dinitrogen reductase) hydrolase - - 3.2.2.24 ko:K05521 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH CMS1_k127_5462868_0 335543.Sfum_0829 3.735e-97 323.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2MREJ@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_5462868_1 1121405.dsmv_2388 1.059e-15 79.0 COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM Coenzyme A transferase - - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans CMS1_k127_5466051_0 251221.35211725 1.107e-115 392.0 COG0346@1|root,COG0346@2|Bacteria,1G29P@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase CMS1_k127_5466051_1 861299.J421_1872 2.187e-92 306.0 COG2303@1|root,COG2303@2|Bacteria 2|Bacteria E choline dehydrogenase activity - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N CMS1_k127_5474767_3 335543.Sfum_3557 3.978e-26 113.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42SWD@68525|delta/epsilon subdivisions,2WK1W@28221|Deltaproteobacteria,2MQCQ@213462|Syntrophobacterales 28221|Deltaproteobacteria K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 CMS1_k127_5474767_1 700598.Niako_7010 3.849e-102 357.0 COG2234@1|root,COG2234@2|Bacteria,4NIAY@976|Bacteroidetes,1IVXK@117747|Sphingobacteriia 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS1_k127_5474767_0 1173022.Cri9333_0749 6.425e-160 509.0 COG0667@1|root,COG0667@2|Bacteria,1G3WV@1117|Cyanobacteria,1HH84@1150|Oscillatoriales 1117|Cyanobacteria C Aldo/keto reductase family - - 1.1.1.91 ko:K05882 - - - - ko00000,ko01000 - - - Aldo_ket_red CMS1_k127_5474767_2 234267.Acid_1440 4.523e-43 179.0 COG0639@1|root,COG0639@2|Bacteria 2|Bacteria T phosphoprotein phosphatase activity - - 6.5.1.3 ko:K14680 - - - - ko00000,ko01000 - - - Metallophos_2,RNA_lig_T4_1 CMS1_k127_5474767_4 880073.Calab_0598 1.727e-05 54.0 COG0399@1|root,COG0399@2|Bacteria,2NS1A@2323|unclassified Bacteria 2|Bacteria M 23S rRNA-intervening sequence protein - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - 23S_rRNA_IVP,DegT_DnrJ_EryC1 CMS1_k127_5483051_4 1041930.Mtc_0198 2.272e-30 138.0 COG1216@1|root,arCOG01383@2157|Archaea,2XUCM@28890|Euryarchaeota,2NAQ3@224756|Methanomicrobia 224756|Methanomicrobia M Glycosyl transferase family 2 - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3 CMS1_k127_5483051_3 641491.DND132_1483 1.172e-79 280.0 COG0438@1|root,COG0438@2|Bacteria,1N1RZ@1224|Proteobacteria,42UHY@68525|delta/epsilon subdivisions,2WQD7@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_5483051_0 880073.Calab_1845 2.565e-93 329.0 COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 arnC - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 CMS1_k127_5483051_1 272123.Anacy_1118 5.508e-93 316.0 COG0451@1|root,COG0451@2|Bacteria,1G0GJ@1117|Cyanobacteria,1HIYE@1161|Nostocales 1117|Cyanobacteria GM PFAM NAD dependent epimerase dehydratase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd CMS1_k127_5483051_2 1379698.RBG1_1C00001G0356 1.342e-89 324.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,2NS3S@2323|unclassified Bacteria 2|Bacteria EG Protein of unknown function (DUF2723) - - - ko:K16928 - M00582 - - ko00000,ko00002,ko02000 3.A.1.33 - - DUF2723,QueT CMS1_k127_5488633_0 926550.CLDAP_09040 4.93e-43 177.0 COG1122@1|root,COG1122@2|Bacteria,2G5RY@200795|Chloroflexi 200795|Chloroflexi P PFAM ABC transporter related ecfA - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran CMS1_k127_5488633_1 1379698.RBG1_1C00001G1816 5.849e-28 124.0 COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NR9R@2323|unclassified Bacteria 2|Bacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - DUF2723,PMT_2,TPR_8 CMS1_k127_5497541_4 1232410.KI421414_gene2816 9.615e-66 228.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,43W1B@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS1_k127_5497541_2 1041159.AZUW01000033_gene2465 8.605e-107 377.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2U4F6@28211|Alphaproteobacteria,4BCVF@82115|Rhizobiaceae 28211|Alphaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth CMS1_k127_5497541_1 661478.OP10G_1638 4.556e-237 745.0 COG0659@1|root,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - iSbBS512_1146.SbBS512_E1370 STAS,Sulfate_transp CMS1_k127_5497541_3 713586.KB900536_gene1447 1.745e-71 256.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WWA8@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 CMS1_k127_5497541_0 396588.Tgr7_0704 1.02e-321 1016.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran CMS1_k127_5504808_0 1382359.JIAL01000001_gene577 2.336e-207 661.0 COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia 204432|Acidobacteriia T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 CMS1_k127_5505620_2 926561.KB900618_gene414 1.114e-18 89.0 COG1670@1|root,COG1670@2|Bacteria,1V36S@1239|Firmicutes,24FW8@186801|Clostridia 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 CMS1_k127_5505620_1 349163.Acry_2988 2.628e-99 350.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,2TSSM@28211|Alphaproteobacteria,2JR62@204441|Rhodospirillales 204441|Rhodospirillales IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short_C2 CMS1_k127_5505620_0 402626.Rpic_2457 3.935e-116 378.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1JZZQ@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the thiolase family pcaF - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_5510699_0 1499967.BAYZ01000171_gene5603 4.918e-155 494.0 COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria 2|Bacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS1_k127_5510699_1 682795.AciX8_4887 3.891e-51 201.0 COG1287@1|root,COG1287@2|Bacteria,3Y653@57723|Acidobacteria,2JM89@204432|Acidobacteriia 204432|Acidobacteriia S oligosaccharyl transferase activity - - - - - - - - - - - - - CMS1_k127_5510699_4 266264.Rmet_2425 1.889e-08 66.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,1K1T9@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_5510699_2 1192034.CAP_0783 9.754e-51 204.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,4346X@68525|delta/epsilon subdivisions,2XA3R@28221|Deltaproteobacteria,2YXWE@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS1_k127_5510699_5 1118235.CAJH01000059_gene3342 4.884e-06 52.0 COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R9NB@1224|Proteobacteria,1S1MC@1236|Gammaproteobacteria,1XCAK@135614|Xanthomonadales 135614|Xanthomonadales T Two component regulator propeller - - - - - - - - - - - - GGDEF,Reg_prop,Y_Y_Y CMS1_k127_5510699_6 1089551.KE386572_gene722 1.09e-05 56.0 COG5010@1|root,COG5010@2|Bacteria,1MVTK@1224|Proteobacteria,2TVBA@28211|Alphaproteobacteria,4BR3Q@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria U COG0457 FOG TPR repeat MA20_18455 - - - - - - - - - - - TPR_10,TPR_12,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8 CMS1_k127_5510699_3 96561.Dole_3024 1.626e-43 182.0 COG3386@1|root,COG3391@1|root,COG4783@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,COG4783@2|Bacteria,1PE62@1224|Proteobacteria,43768@68525|delta/epsilon subdivisions,2X25C@28221|Deltaproteobacteria,2MP74@213118|Desulfobacterales 28221|Deltaproteobacteria G amine dehydrogenase activity - - - - - - - - - - - - - CMS1_k127_55186_1 880073.Calab_0680 6.439e-08 56.0 COG1366@1|root,COG1366@2|Bacteria,2NR50@2323|unclassified Bacteria 2|Bacteria T Anti-sigma factor antagonist - - - ko:K04749,ko:K06378 - - - - ko00000,ko03021 - - - STAS,STAS_2 CMS1_k127_55186_0 880073.Calab_0681 2.78e-147 496.0 COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2NP51@2323|unclassified Bacteria 2|Bacteria KT Sigma factor PP2C-like phosphatases pkn5 - 2.7.11.1,3.1.3.3 ko:K04757,ko:K07315 - - - - ko00000,ko01000,ko01001,ko03021 - - - AAA_16,GAF,HAMP,HATPase_c_2,Pkinase,SpoIIE,dCache_1 CMS1_k127_5531413_0 880072.Desac_2552 2.812e-112 379.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MQKP@213462|Syntrophobacterales 28221|Deltaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN CMS1_k127_5535996_1 1124780.ANNU01000008_gene2735 9.483e-51 189.0 COG1215@1|root,COG1215@2|Bacteria,4NEK9@976|Bacteroidetes,47MJK@768503|Cytophagia 976|Bacteroidetes M glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 CMS1_k127_5535996_0 247490.KSU1_B0460 3.218e-53 211.0 COG3387@1|root,COG3387@2|Bacteria 2|Bacteria G glucan 1,4-alpha-glucosidase activity - - - - - - - - - - - - Glyco_hydro_15 CMS1_k127_5537062_3 365528.KB891274_gene2643 5.399e-13 77.0 COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cu_amine_oxidN1,NHL,Pkinase CMS1_k127_5537062_2 105422.BBPM01000058_gene4584 3.039e-23 105.0 2EF2D@1|root,338VG@2|Bacteria,2IB4P@201174|Actinobacteria,2NIW4@228398|Streptacidiphilus 201174|Actinobacteria S SMI1-KNR4 cell-wall - - - - - - - - - - - - SUKH_6 CMS1_k127_5537062_1 477184.KYC_14907 2.486e-23 105.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VII1@28216|Betaproteobacteria 28216|Betaproteobacteria L similarity to GP 17427840 - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve_3 CMS1_k127_5537062_4 889378.Spiaf_0486 0.0001483 48.0 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - 3.1.21.4 ko:K01155 - - - - ko00000,ko01000,ko02048 - - - Endonuc-PvuII,HTH_3,HTH_31 CMS1_k127_5537062_0 1095769.CAHF01000022_gene432 1.437e-158 564.0 COG3209@1|root,COG3209@2|Bacteria,1QJCC@1224|Proteobacteria,2WF53@28216|Betaproteobacteria 28216|Betaproteobacteria M COG3209 Rhs family protein - - - ko:K11021 - - - - ko00000,ko02042 - - - SpvB,TcdB_toxin_midC,TcdB_toxin_midN CMS1_k127_5544764_2 498848.TaqDRAFT_5363 7.313e-66 229.0 COG0001@1|root,COG0001@2|Bacteria,1WJ8G@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_5544764_1 1125863.JAFN01000001_gene1119 7.082e-89 313.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2WJZK@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0016 URO-D CMS1_k127_5544764_0 246197.MXAN_5532 8.337e-132 453.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42M87@68525|delta/epsilon subdivisions,2WMB0@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN - - - - - - - - - - - HemN_C,Radical_SAM CMS1_k127_5544764_3 1232410.KI421415_gene3101 4.183e-63 242.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,43RXT@69541|Desulfuromonadales 28221|Deltaproteobacteria H Ferrochelatase hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase CMS1_k127_5556354_0 518766.Rmar_2045 7.738e-254 796.0 COG0481@1|root,COG0481@2|Bacteria,4NEJ9@976|Bacteroidetes,1FIPT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C CMS1_k127_5556354_2 1379698.RBG1_1C00001G0425 5.991e-59 216.0 COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria 2|Bacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 CMS1_k127_5556354_1 1370120.AUWR01000008_gene556 9.941e-69 244.0 COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,233HD@1762|Mycobacteriaceae 201174|Actinobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - iNJ661.Rv2388c HemN_C,Radical_SAM CMS1_k127_5563445_2 518766.Rmar_2201 3.25e-57 216.0 COG1629@1|root,COG4771@2|Bacteria,4NDX3@976|Bacteroidetes,1FISC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS1_k127_5563445_0 1379698.RBG1_1C00001G0607 1.503e-128 441.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 CMS1_k127_5563445_1 1123508.JH636439_gene1351 2.459e-80 281.0 COG1253@1|root,COG1253@2|Bacteria,2IYEG@203682|Planctomycetes 203682|Planctomycetes S CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 CMS1_k127_5572813_0 370438.PTH_2720 9.29e-169 542.0 COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,2602C@186807|Peptococcaceae 186801|Clostridia G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N CMS1_k127_5572813_2 1379698.RBG1_1C00001G1142 7.572e-67 241.0 COG0616@1|root,COG0616@2|Bacteria,2NPIE@2323|unclassified Bacteria 2|Bacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 CMS1_k127_5572813_3 1379698.RBG1_1C00001G1143 4.693e-25 107.0 COG0776@1|root,COG0776@2|Bacteria,2NPU6@2323|unclassified Bacteria 2|Bacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup_1 - - ko:K03530,ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS1_k127_5572813_1 518766.Rmar_1200 5.259e-94 328.0 COG0557@1|root,COG0557@2|Bacteria,4NE7T@976|Bacteroidetes,1FIPN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573,ko:K12585 ko03018,map03018 M00391 - - ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 CMS1_k127_5576065_1 313606.M23134_05560 2.828e-77 261.0 COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,47JE5@768503|Cytophagia 976|Bacteroidetes C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS1_k127_5576065_2 1121920.AUAU01000004_gene643 5.877e-76 261.0 2CAZH@1|root,2Z7RU@2|Bacteria,3Y4WA@57723|Acidobacteria 57723|Acidobacteria - - - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt CMS1_k127_5576065_5 1379698.RBG1_1C00001G0565 1.494e-40 172.0 COG2834@1|root,COG2834@2|Bacteria,2NQJ8@2323|unclassified Bacteria 2|Bacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - DUF4292,DUF4367,LolA_like CMS1_k127_5576065_0 926561.KB900618_gene312 3.235e-170 562.0 COG1033@1|root,COG1033@2|Bacteria 2|Bacteria S growth of symbiont in host cell - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL CMS1_k127_5576065_7 56780.SYN_03386 5.817e-15 80.0 2BWVJ@1|root,33YN1@2|Bacteria,1NXTC@1224|Proteobacteria,430BZ@68525|delta/epsilon subdivisions,2WVZK@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_5576065_3 861299.J421_2051 5.502e-71 251.0 COG1028@1|root,COG1028@2|Bacteria 861299.J421_2051|- IQ oxidoreductase activity, acting on CH-OH group of donors - - - - - - - - - - - - - CMS1_k127_5576065_4 1279009.ADICEAN_01858 2.566e-52 188.0 COG3565@1|root,COG3565@2|Bacteria,4NNHW@976|Bacteroidetes,47PTX@768503|Cytophagia 976|Bacteroidetes S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K06991 - - - - ko00000 - - - Glyoxalase CMS1_k127_5576065_6 1303518.CCALI_01109 1.686e-19 93.0 COG0665@1|root,COG0665@2|Bacteria 2|Bacteria E tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO CMS1_k127_5605747_2 224911.27355297 1.708e-32 134.0 COG0642@1|root,COG0784@1|root,COG3447@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3447@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3JW8Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,dCache_1 CMS1_k127_5605747_0 1121920.AUAU01000008_gene1626 1.003e-58 215.0 COG2197@1|root,COG2197@2|Bacteria,3Y7XN@57723|Acidobacteria 57723|Acidobacteria KT helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg CMS1_k127_5605747_1 1047013.AQSP01000101_gene615 4.858e-43 173.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Gp58 CMS1_k127_5636972_2 1125863.JAFN01000001_gene1341 2.749e-35 141.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2WJ8I@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS1_k127_5636972_0 56780.SYN_01524 1.792e-110 377.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MR54@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS1_k127_5636972_1 246194.CHY_2047 2.613e-37 146.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales 186801|Clostridia K Response regulator receiver phoB - - ko:K02483,ko:K07658,ko:K07668 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C CMS1_k127_5646484_2 1382304.JNIL01000001_gene500 1.945e-46 176.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4HA13@91061|Bacilli 91061|Bacilli E Aminotransferase - - - - - - - - - - - - Aminotran_1_2 CMS1_k127_5646484_0 1254432.SCE1572_24070 0.0 1291.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2WIQY@28221|Deltaproteobacteria,2Z2XJ@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran CMS1_k127_5646484_1 316067.Geob_0204 2.671e-89 317.0 COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,42T6A@68525|delta/epsilon subdivisions,2WPV8@28221|Deltaproteobacteria,43UYM@69541|Desulfuromonadales 28221|Deltaproteobacteria M HlyD family secretion protein - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 CMS1_k127_5646484_3 502025.Hoch_1464 2.698e-25 118.0 COG0845@1|root,COG0845@2|Bacteria,1P3X6@1224|Proteobacteria,431K1@68525|delta/epsilon subdivisions,2WWAD@28221|Deltaproteobacteria,2Z240@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - - CMS1_k127_5646484_4 316067.Geob_0206 4.022e-25 119.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP CMS1_k127_5656985_1 1192034.CAP_6745 1.592e-17 89.0 COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2X9TY@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate - - 3.5.4.25 ko:K01497 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125 R00425 RC00293,RC02504 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydro2 CMS1_k127_5656985_0 290397.Adeh_0507 8.102e-70 251.0 COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria,435D1@68525|delta/epsilon subdivisions,2X984@28221|Deltaproteobacteria,2Z2IU@29|Myxococcales 28221|Deltaproteobacteria S Flavin containing amine oxidoreductase - - - ko:K06955 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 CMS1_k127_5656985_2 251221.35210948 5.248e-13 69.0 COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,1G3NB@1117|Cyanobacteria 1117|Cyanobacteria O PFAM AhpC TSA family - - - - - - - - - - - - AhpC-TSA,NHL,Thioredoxin_8 CMS1_k127_5660869_1 1379698.RBG1_1C00001G0147 3.571e-16 81.0 COG0636@1|root,COG0636@2|Bacteria,2NQ21@2323|unclassified Bacteria 2|Bacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C CMS1_k127_5660869_0 1437425.CSEC_0648 9.33e-47 186.0 COG0356@1|root,COG0356@2|Bacteria,2JFFC@204428|Chlamydiae 204428|Chlamydiae C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A CMS1_k127_5660869_2 1379698.RBG1_1C00001G0144 1.084e-12 72.0 2EQQP@1|root,33IAK@2|Bacteria 2|Bacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 CMS1_k127_5689343_0 1121015.N789_00865 3.899e-137 444.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria 1236|Gammaproteobacteria HJ GNAT family acetyltransferase cphA - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - ATP-grasp_5,CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK CMS1_k127_5689343_1 1121013.P873_12395 5.235e-105 352.0 COG4242@1|root,COG4242@2|Bacteria,1PR9J@1224|Proteobacteria,1RVJH@1236|Gammaproteobacteria,1X9SP@135614|Xanthomonadales 135614|Xanthomonadales PQ Peptidase family S51 - - 3.4.15.6 ko:K13282 - - R09722 RC00064,RC00141 ko00000,ko01000,ko01002 - - - Peptidase_S51 CMS1_k127_5689343_2 452637.Oter_2574 1.418e-85 291.0 COG0288@1|root,COG0288@2|Bacteria,46S9J@74201|Verrucomicrobia,3K7VC@414999|Opitutae 414999|Opitutae P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA CMS1_k127_5689343_3 234267.Acid_5657 1.744e-10 63.0 COG5349@1|root,COG5349@2|Bacteria 2|Bacteria S Protein of unknown function (DUF983) MA20_36345 - - - - - - - - - - - DUF983 CMS1_k127_5691760_0 379066.GAU_2847 1.256e-43 174.0 2ARQH@1|root,31H1J@2|Bacteria,1ZUJU@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Phosphodiester glycosidase - - - - - - - - - - - - NAGPA CMS1_k127_5712995_2 1439940.BAY1663_03778 2.814e-06 55.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 CMS1_k127_5712995_0 1232410.KI421415_gene3035 1.269e-64 235.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,43UAY@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1885 PdxJ CMS1_k127_5712995_1 1191523.MROS_1073 4.845e-47 184.0 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - ko:K09476 ko01501,ko02020,map01501,map02020 M00746 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.1.1.1 - - Porin_4 CMS1_k127_5726815_4 565045.NOR51B_2004 5.039e-46 173.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1J5K7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion macA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_5726815_3 292459.STH976 7.971e-82 280.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia 186801|Clostridia V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_5726815_1 765912.Thimo_1431 1.066e-93 331.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXP0@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5726815_2 565045.NOR51B_1193 1.832e-92 333.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system, permease component VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5726815_5 1385935.N836_35430 6.327e-15 86.0 2EPF5@1|root,33H1T@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5726815_0 489825.LYNGBM3L_56740 6.229e-118 391.0 COG1404@1|root,COG1404@2|Bacteria,1G04D@1117|Cyanobacteria,1H779@1150|Oscillatoriales 1117|Cyanobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Calx-beta,HemolysinCabind,Peptidase_S8,SdrD_B CMS1_k127_5734289_2 742818.HMPREF9451_01636 0.0002689 46.0 COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4CUNC@84998|Coriobacteriia 84998|Coriobacteriia L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N CMS1_k127_5734289_1 1121377.KB906398_gene2409 2.68e-05 53.0 COG5512@1|root,COG5512@2|Bacteria,1WIYS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 CMS1_k127_5734289_0 1379698.RBG1_1C00001G0271 1.111e-264 828.0 COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria 2|Bacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim CMS1_k127_5734552_5 391595.RLO149_c031200 4.878e-22 113.0 COG2885@1|root,COG2911@1|root,COG2931@1|root,COG2885@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2P3XE@2433|Roseobacter 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - An_peroxidase,Cadherin,Calx-beta,Exo_endo_phos,HemolysinCabind,Metallophos,Peptidase_M10_C CMS1_k127_5734552_1 439235.Dalk_2389 7.781e-136 461.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2MHR7@213118|Desulfobacterales 28221|Deltaproteobacteria G phosphoglucomutase phosphomannomutase alpha beta alpha domain I algC - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS1_k127_5734552_2 634956.Geoth_0394 2.151e-123 405.0 COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,4H9N2@91061|Bacilli,1WF5G@129337|Geobacillus 91061|Bacilli J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 CMS1_k127_5734552_4 136273.GY22_02975 9.825e-28 119.0 COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,1W8VX@1268|Micrococcaceae 201174|Actinobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE,GrpB CMS1_k127_5734552_0 1379698.RBG1_1C00001G0871 1.764e-219 717.0 COG0749@1|root,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria 2|Bacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 CMS1_k127_5734552_3 309801.trd_0651 1.17e-44 180.0 COG1057@1|root,COG1057@2|Bacteria,2G6MY@200795|Chloroflexi,27Y96@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like CMS1_k127_5734552_6 1121012.AUKX01000041_gene3254 6.969e-11 73.0 COG4105@1|root,COG4105@2|Bacteria,4NJ5A@976|Bacteroidetes,1HYEQ@117743|Flavobacteriia,23GQ8@178469|Arenibacter 976|Bacteroidetes S Tetratricopeptide repeat yfiO - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO CMS1_k127_5741715_0 1379698.RBG1_1C00001G0820 3.019e-147 480.0 COG0621@1|root,COG0621@2|Bacteria,2NNUN@2323|unclassified Bacteria 2|Bacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 CMS1_k127_5741715_1 870187.Thini_0773 2.171e-84 280.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,460AM@72273|Thiotrichales 72273|Thiotrichales F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - Intein_splicing,dUTPase CMS1_k127_5768677_0 240015.ACP_0328 2.331e-227 720.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia 204432|Acidobacteriia C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N CMS1_k127_5768677_1 404589.Anae109_2993 1.254e-127 436.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42P3Y@68525|delta/epsilon subdivisions,2WJG5@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C CMS1_k127_5768677_3 631454.N177_0392 0.0002151 48.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,1JPV7@119043|Rhodobiaceae 28211|Alphaproteobacteria P Heavy-metal-associated domain actP - 3.6.3.54 ko:K17686,ko:K19597 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5,3.A.3.5.20 - - E1-E2_ATPase,HMA,Hydrolase CMS1_k127_5768677_2 1379698.RBG1_1C00001G1850 9.101e-23 102.0 COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria 2|Bacteria S Rhomboid family - - - - - - - - - - - - Rhomboid CMS1_k127_5780093_9 1121456.ATVA01000017_gene238 7.634e-22 111.0 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,43D25@68525|delta/epsilon subdivisions,2X6CE@28221|Deltaproteobacteria 28221|Deltaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec CMS1_k127_5780093_7 1179773.BN6_51740 1.045e-42 177.0 2EFIY@1|root,339BC@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5780093_8 1114970.PSF113_0919 3.367e-33 136.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1S9P2@1236|Gammaproteobacteria,1YQJ2@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1 CMS1_k127_5780093_1 1191523.MROS_0749 8.657e-141 466.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM CMS1_k127_5780093_4 284031.JNXD01000004_gene1258 1.322e-59 216.0 COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria 201174|Actinobacteria T response regulator, receiver resD - - - - - - - - - - - Response_reg,Trans_reg_C CMS1_k127_5780093_5 309807.SRU_2487 3.379e-48 196.0 COG0642@1|root,COG2205@2|Bacteria,4NGAS@976|Bacteroidetes 976|Bacteroidetes T histidine kinase-, DNA gyrase B - - - - - - - - - - - - HAMP,HATPase_c,HisKA,TPR_8 CMS1_k127_5780093_3 326427.Cagg_3772 7.571e-60 239.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2G7ZS@200795|Chloroflexi,3757W@32061|Chloroflexia 32061|Chloroflexia KLT Serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8 CMS1_k127_5780093_0 1242864.D187_001830 4.595e-147 516.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2YWHV@29|Myxococcales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12 CMS1_k127_5780093_6 234267.Acid_6539 4.779e-48 187.0 COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria 57723|Acidobacteria S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 CMS1_k127_5780093_2 1267533.KB906733_gene3472 2.635e-91 323.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria 57723|Acidobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_12,TPR_8 CMS1_k127_578548_0 44056.XP_009033965.1 1.236e-128 449.0 29QRV@1|root,2RX97@2759|Eukaryota 2759|Eukaryota S Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - - - - - - - - - - REJ,VCBS CMS1_k127_578548_7 237368.SCABRO_03007 3.847e-07 64.0 2A1MP@1|root,30PVX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_578548_4 333138.LQ50_14255 8.531e-24 116.0 COG3153@1|root,COG3153@2|Bacteria,1V0I4@1239|Firmicutes,4HCMH@91061|Bacilli,1ZJWG@1386|Bacillus 91061|Bacilli S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_9 CMS1_k127_578548_8 452662.SJA_C2-02140 0.0002241 53.0 COG0236@1|root,COG0236@2|Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP2 - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding CMS1_k127_578548_1 234267.Acid_7156 3.926e-111 387.0 COG3882@1|root,COG3882@2|Bacteria 2|Bacteria Q phosphopantetheine binding - - - - - - - - - - - - - CMS1_k127_578548_6 941449.dsx2_1099 1.595e-21 106.0 COG2227@1|root,COG2227@2|Bacteria,1RKH0@1224|Proteobacteria,42Q2I@68525|delta/epsilon subdivisions,2WJME@28221|Deltaproteobacteria,2M9G0@213115|Desulfovibrionales 28221|Deltaproteobacteria H PFAM Methyltransferase type - - - - - - - - - - - - Methyltransf_23 CMS1_k127_578548_2 1278073.MYSTI_02787 1.538e-25 115.0 2ESNI@1|root,33K73@2|Bacteria,1Q2MV@1224|Proteobacteria,4388I@68525|delta/epsilon subdivisions,2X3I7@28221|Deltaproteobacteria,2YW7A@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - DUF2378 CMS1_k127_578548_3 1242864.D187_003993 2.071e-25 113.0 2ESNI@1|root,33K73@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF2378 CMS1_k127_578548_5 1461693.ATO10_12554 8.988e-24 106.0 COG3379@1|root,COG3379@2|Bacteria,1NBJ6@1224|Proteobacteria,2U12I@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest CMS1_k127_57859_0 744872.Spica_1509 1.626e-115 384.0 COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes 203691|Spirochaetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains rrp-2 - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_57859_1 903818.KI912268_gene3039 1.669e-08 68.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - MA20_04930 - - - - - - - - - - - LVIVD CMS1_k127_5787378_5 479431.Namu_4733 2.308e-05 50.0 COG0346@1|root,COG0346@2|Bacteria,2IPGW@201174|Actinobacteria 201174|Actinobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase CMS1_k127_5787378_3 290397.Adeh_0728 3.463e-24 108.0 2DVJC@1|root,33W5M@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5787378_1 448385.sce8846 8.8e-59 206.0 COG0640@1|root,COG0640@2|Bacteria,1RH4V@1224|Proteobacteria,43AH1@68525|delta/epsilon subdivisions,2X5X1@28221|Deltaproteobacteria,2Z038@29|Myxococcales 28221|Deltaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 CMS1_k127_5787378_0 1287276.X752_23975 2.932e-72 247.0 COG3832@1|root,COG3832@2|Bacteria,1RJKI@1224|Proteobacteria,2UAQG@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Activator of Hsp90 ATPase - - - - - - - - - - - - AHSA1 CMS1_k127_5787378_2 317013.NY99_06885 3.117e-45 168.0 COG0507@1|root,COG0507@2|Bacteria,1MUTR@1224|Proteobacteria,1RMA4@1236|Gammaproteobacteria,1X9Z0@135614|Xanthomonadales 135614|Xanthomonadales L TrwC relaxase - - - - - - - - - - - - AAA_30,TrwC,Viral_helicase1 CMS1_k127_5787378_4 533247.CRD_00605 1.422e-07 54.0 COG3415@1|root,COG3415@2|Bacteria,1G97I@1117|Cyanobacteria,1HPPY@1161|Nostocales 1117|Cyanobacteria L Helix-turn-helix domain - - - - - - - - - - - - HTH_28,HTH_Tnp_IS630,PAX CMS1_k127_5817203_4 1173264.KI913949_gene945 1.458e-05 51.0 COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1GQ4V@1117|Cyanobacteria,1HI04@1150|Oscillatoriales 1117|Cyanobacteria NT Methyltransferase, chemotaxis proteins - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,PAS_10 CMS1_k127_5817203_3 1123393.KB891326_gene87 4.371e-20 95.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2VKCX@28216|Betaproteobacteria 28216|Betaproteobacteria G Phosphoglucomutase phosphomannomutase alpha beta alpha domain I pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS1_k127_5817203_2 251221.35210659 2.549e-64 232.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg CMS1_k127_5817203_0 502025.Hoch_6589 3.151e-240 752.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS1_k127_5817203_1 485913.Krac_11550 6.987e-85 306.0 COG1814@1|root,COG1814@2|Bacteria,2G7AE@200795|Chloroflexi 200795|Chloroflexi S VIT family - - - - - - - - - - - - VIT1 CMS1_k127_5817383_0 1267535.KB906767_gene2605 0.0 1150.0 COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia 204432|Acidobacteriia C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase CMS1_k127_5825678_1 237368.SCABRO_02612 6.188e-70 242.0 COG0495@1|root,COG0495@2|Bacteria,2IX36@203682|Planctomycetes 203682|Planctomycetes J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 CMS1_k127_5825678_3 1499967.BAYZ01000182_gene4418 1.108e-14 81.0 COG2980@1|root,COG2980@2|Bacteria,2NQ1I@2323|unclassified Bacteria 2|Bacteria M Evidence 5 No homology to any previously reported sequences lptE GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788 LptE CMS1_k127_5825678_0 1232410.KI421428_gene1054 8.307e-131 432.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains REC, sigma54 interaction, HTH8 - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_5825678_2 882.DVU_3382 1.169e-62 233.0 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2M8UQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,sCache_3_2 CMS1_k127_5833758_0 880073.Calab_1976 6.712e-165 536.0 COG1387@1|root,COG1387@2|Bacteria,2NNNK@2323|unclassified Bacteria 2|Bacteria L DNA polymerase X family dpx - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_thumb,HHH_5,HHH_8,PHP CMS1_k127_5833758_1 1396418.BATQ01000123_gene4935 6.855e-29 125.0 COG3590@1|root,COG3590@2|Bacteria 2|Bacteria O peptidase - - - - - - - - - - - - - CMS1_k127_5835642_1 290397.Adeh_0511 2.556e-34 146.0 COG0475@1|root,COG0475@2|Bacteria,1RA3J@1224|Proteobacteria,43EWJ@68525|delta/epsilon subdivisions,2WTW1@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger CMS1_k127_5835642_3 266117.Rxyl_1803 1.68e-23 109.0 COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4CPNY@84995|Rubrobacteria 84995|Rubrobacteria K helix_turn_helix, cAMP Regulatory protein - - - ko:K21564 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding CMS1_k127_5835642_2 1124780.ANNU01000013_gene3870 2.394e-24 110.0 COG2010@1|root,COG2010@2|Bacteria,4NMD5@976|Bacteroidetes,47R42@768503|Cytophagia 976|Bacteroidetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C CMS1_k127_5835642_0 452637.Oter_1803 5.835e-129 421.0 COG4263@1|root,COG4263@2|Bacteria,46YT5@74201|Verrucomicrobia,3K7SZ@414999|Opitutae 414999|Opitutae C Cupredoxin-like domain - - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - Cupredoxin_1 CMS1_k127_586393_0 518766.Rmar_2753 7.137e-79 279.0 COG2103@1|root,COG2103@2|Bacteria,4NEPY@976|Bacteroidetes,1FIKZ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS,SIS_2 CMS1_k127_586393_1 395493.BegalDRAFT_1833 3.19e-26 126.0 COG1572@1|root,COG1572@2|Bacteria,1N1AP@1224|Proteobacteria,1SQWS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase family C25 - - - - - - - - - - - - Peptidase_C25 CMS1_k127_5865670_1 264732.Moth_2169 1.579e-16 82.0 COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,24RC0@186801|Clostridia,42H66@68295|Thermoanaerobacterales 186801|Clostridia I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS01470 ACPS CMS1_k127_5865670_0 1121468.AUBR01000010_gene2431 2.729e-106 367.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,42EWB@68295|Thermoanaerobacterales 186801|Clostridia H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - ACPS,Carb_kinase,YjeF_N CMS1_k127_5865670_2 1120999.JONM01000009_gene266 1.182e-07 59.0 COG0235@1|root,COG0235@2|Bacteria,1RE8T@1224|Proteobacteria,2W2A1@28216|Betaproteobacteria 28216|Betaproteobacteria G Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II CMS1_k127_5867679_0 671143.DAMO_1298 1.993e-83 284.0 COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria 2|Bacteria T COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_5867679_1 1210908.HSB1_21360 0.0002182 53.0 arCOG08110@1|root,arCOG08110@2157|Archaea,2XUWV@28890|Euryarchaeota,23S8I@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - CMS1_k127_5871548_4 1297742.A176_01298 9.49e-24 102.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran CMS1_k127_5871548_5 452637.Oter_2808 1.318e-20 100.0 COG0824@1|root,COG0824@2|Bacteria,46YJD@74201|Verrucomicrobia,3K9QG@414999|Opitutae 414999|Opitutae S Thioesterase-like superfamily - - 3.1.2.28 ko:K12073 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07262 RC00004,RC00174 ko00000,ko00001,ko00002,ko01000 - - - - CMS1_k127_5871548_0 479434.Sthe_3015 4.455e-106 376.0 COG0318@1|root,COG0318@2|Bacteria,2G7PF@200795|Chloroflexi,27XJD@189775|Thermomicrobia 189775|Thermomicrobia IQ Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C CMS1_k127_5871548_3 309800.C498_11426 1.841e-44 179.0 COG4948@1|root,arCOG01168@2157|Archaea,2XU6X@28890|Euryarchaeota,23SAR@183963|Halobacteria 183963|Halobacteria H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - - - - - - - - - - - MR_MLE_C,MR_MLE_N CMS1_k127_5871548_2 502025.Hoch_5718 2.692e-78 280.0 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,42S34@68525|delta/epsilon subdivisions,2X5AY@28221|Deltaproteobacteria,2Z34Z@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the MenA family. Type 1 subfamily menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA CMS1_k127_5871548_1 349741.Amuc_0351 5.951e-106 345.0 COG0447@1|root,COG0447@2|Bacteria,46Z3Z@74201|Verrucomicrobia,2ITPX@203494|Verrucomicrobiae 203494|Verrucomicrobiae H Enoyl-CoA hydratase/isomerase menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_5875504_2 204669.Acid345_4392 1.187e-195 639.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria 57723|Acidobacteria KLTU Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40,Pkinase CMS1_k127_5875504_3 1267535.KB906767_gene4657 1.829e-141 465.0 COG3852@1|root,COG3852@2|Bacteria,3Y3JR@57723|Acidobacteria,2JIY1@204432|Acidobacteriia 204432|Acidobacteriia T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HATPase_c,cNMP_binding CMS1_k127_5875504_5 1121377.KB906400_gene1348 7.848e-107 362.0 COG3852@1|root,COG3852@2|Bacteria,1WMD2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c CMS1_k127_5875504_1 306281.AJLK01000109_gene3219 1.787e-217 688.0 COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1JHD5@1189|Stigonemataceae 1117|Cyanobacteria KOT Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Response_reg CMS1_k127_5875504_6 187272.Mlg_2775 2.872e-98 332.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,1WXWQ@135613|Chromatiales 135613|Chromatiales L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH CMS1_k127_5875504_0 1454004.AW11_03339 1.973e-260 812.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,1KQ68@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM CMS1_k127_5875504_4 1095769.CAHF01000001_gene3462 1.714e-108 357.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,47348@75682|Oxalobacteraceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB CMS1_k127_5878750_6 1463903.JOIZ01000008_gene4327 0.0005154 49.0 COG2334@1|root,COG2334@2|Bacteria,2GIYP@201174|Actinobacteria 201174|Actinobacteria M Aminoglycoside phosphotransferase - - - - - - - - - - - - APH CMS1_k127_5878750_3 1379698.RBG1_1C00001G1558 1.497e-40 163.0 COG1974@1|root,COG1974@2|Bacteria,2NPJG@2323|unclassified Bacteria 2|Bacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 CMS1_k127_5878750_4 1121447.JONL01000003_gene3096 3.714e-38 148.0 2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,42U4W@68525|delta/epsilon subdivisions,2WQ9S@28221|Deltaproteobacteria,2MCV4@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 CMS1_k127_5878750_2 1036674.A28LD_0671 2.645e-58 211.0 2DPEU@1|root,331SS@2|Bacteria,1NDKB@1224|Proteobacteria,1RTE7@1236|Gammaproteobacteria,2QG29@267893|Idiomarinaceae 1236|Gammaproteobacteria S Golgi phosphoprotein 3 (GPP34) - - - - - - - - - - - - GPP34 CMS1_k127_5878750_1 572544.Ilyop_2823 9.357e-181 582.0 COG0457@1|root,COG0457@2|Bacteria 572544.Ilyop_2823|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_5878750_5 861299.J421_4102 1.604e-13 82.0 COG1629@1|root,COG4771@2|Bacteria,1ZU8C@142182|Gemmatimonadetes 2|Bacteria P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS1_k127_591430_4 393595.ABO_2046 5.301e-11 76.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1XICE@135619|Oceanospirillales 135619|Oceanospirillales M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N CMS1_k127_591430_2 1232410.KI421421_gene3694 8.586e-21 106.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42QU4@68525|delta/epsilon subdivisions,2WMRQ@28221|Deltaproteobacteria,43SHI@69541|Desulfuromonadales 28221|Deltaproteobacteria M Domain amino terminal to FKBP-type peptidyl-prolyl isomerase - - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N CMS1_k127_591430_0 1300345.LF41_834 4.342e-183 623.0 COG1858@1|root,COG1858@2|Bacteria,1MWAT@1224|Proteobacteria,1RN8J@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Di-haem cytochrome c peroxidase - - - - - - - - - - - - CCP_MauG CMS1_k127_5917017_1 994479.GL877878_gene2560 1.289e-11 78.0 COG1287@1|root,COG1287@2|Bacteria,2GMZM@201174|Actinobacteria,4E0ZH@85010|Pseudonocardiales 201174|Actinobacteria S oligosaccharyl transferase activity - - - - - - - - - - - - - CMS1_k127_5917017_0 573370.DMR_21080 2.668e-13 72.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2M8GQ@213115|Desulfovibrionales 28221|Deltaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N CMS1_k127_5937593_8 1121904.ARBP01000028_gene1652 7.814e-46 177.0 COG2194@1|root,COG2194@2|Bacteria 2|Bacteria T sulfuric ester hydrolase activity kbaA GO:0008150,GO:0022603,GO:0042173,GO:0043937,GO:0043938,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 2.7.8.43 ko:K03760,ko:K06349,ko:K19353 ko00540,ko01503,map00540,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,KbaA,Sulfatase CMS1_k127_5937593_16 1121904.ARBP01000028_gene1653 2.144e-13 81.0 COG3311@1|root,COG3311@2|Bacteria 2|Bacteria K DNA excision - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - HTH_17,PTS_EIIA_2 CMS1_k127_5937593_12 1267534.KB906754_gene3295 1.207e-25 109.0 2FCYS@1|root,3451F@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5937593_11 660470.Theba_0632 1.117e-25 119.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase ubiE_2 - - - - - - - - - - - Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31 CMS1_k127_5937593_0 861299.J421_1872 9.922e-239 750.0 COG2303@1|root,COG2303@2|Bacteria 2|Bacteria E choline dehydrogenase activity - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N CMS1_k127_5937593_5 861299.J421_1881 1.427e-61 228.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - An_peroxidase,HemolysinCabind,PD40 CMS1_k127_5937593_7 861299.J421_1880 4.472e-48 191.0 COG1672@1|root,COG1672@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DM13 CMS1_k127_5937593_4 251229.Chro_3613 2.66e-66 242.0 COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria 1117|Cyanobacteria U Belongs to the MIP aquaporin (TC 1.A.8) family - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP CMS1_k127_5937593_18 340177.Cag_1224 1.224e-12 80.0 COG1357@1|root,COG1357@2|Bacteria,1FFC5@1090|Chlorobi 1090|Chlorobi S Pentapeptide repeats (9 copies) - - - - - - - - - - - - Pentapeptide CMS1_k127_5937593_6 861299.J421_1883 2.6e-54 198.0 COG1595@1|root,COG1595@2|Bacteria,1ZV3I@142182|Gemmatimonadetes 2|Bacteria K Sigma-70, region 4 sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_5937593_2 861299.J421_1879 9.049e-166 536.0 COG1252@1|root,COG1252@2|Bacteria,1ZT8C@142182|Gemmatimonadetes 2|Bacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_5937593_3 515635.Dtur_0462 1.281e-103 369.0 COG2723@1|root,COG2723@2|Bacteria 2|Bacteria G beta-glucosidase activity bglB - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1 CMS1_k127_5937593_10 861299.J421_1875 4.073e-35 140.0 COG0662@1|root,COG3193@1|root,COG0662@2|Bacteria,COG3193@2|Bacteria 2|Bacteria G Cupin 2, conserved barrel domain protein - - - ko:K11477 - - - - ko00000 - - - Cupin_2,Haem_degrading CMS1_k127_5937593_9 861299.J421_1875 2.122e-41 168.0 COG0662@1|root,COG3193@1|root,COG0662@2|Bacteria,COG3193@2|Bacteria 2|Bacteria G Cupin 2, conserved barrel domain protein - - - ko:K11477 - - - - ko00000 - - - Cupin_2,Haem_degrading CMS1_k127_5937593_1 861299.J421_1876 6.608e-189 607.0 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL CMS1_k127_5937593_17 263358.VAB18032_13670 4.146e-13 77.0 COG1514@1|root,COG1514@2|Bacteria,2IKMG@201174|Actinobacteria,4DDSK@85008|Micromonosporales 201174|Actinobacteria J 2'-5' RNA ligase superfamily - - - - - - - - - - - - 2_5_RNA_ligase2 CMS1_k127_5937593_13 349521.HCH_02998 1.803e-25 110.0 291WQ@1|root,2ZPGC@2|Bacteria,1P768@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_5937593_15 582899.Hden_2830 5.216e-16 78.0 COG0262@1|root,COG0262@2|Bacteria,1MY3I@1224|Proteobacteria,2U3DT@28211|Alphaproteobacteria,3N7C0@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria H RibD C-terminal domain - - - - - - - - - - - - RibD_C CMS1_k127_5956169_4 706587.Desti_4022 3.521e-25 117.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WMYC@28221|Deltaproteobacteria,2MQGX@213462|Syntrophobacterales 28221|Deltaproteobacteria C Electron transfer flavoprotein domain etfB - - ko:K03521 - - - - ko00000 - - - ETF CMS1_k127_5956169_0 1379698.RBG1_1C00001G1217 2.431e-209 668.0 COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2NP05@2323|unclassified Bacteria 2|Bacteria H Methylenetetrahydrofolate reductase yitJ - 1.5.1.20,2.1.1.10,2.1.1.13 ko:K00297,ko:K00547,ko:K00548 ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,ko01523,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230,map01523 M00017,M00377 R00650,R00946,R01224,R07168,R09365 RC00003,RC00035,RC00081,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0504 MTHFR,S-methyl_trans CMS1_k127_5956169_3 1379698.RBG1_1C00001G1716 1.275e-56 215.0 COG0544@1|root,COG0544@2|Bacteria,2NPBN@2323|unclassified Bacteria 2|Bacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N CMS1_k127_5956169_2 1158318.ATXC01000001_gene1441 6.192e-91 303.0 COG0740@1|root,COG0740@2|Bacteria,2G3IM@200783|Aquificae 200783|Aquificae O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease CMS1_k127_5956169_1 643648.Slip_0313 1.041e-179 572.0 COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,42JS2@68298|Syntrophomonadaceae 186801|Clostridia O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX CMS1_k127_5973006_1 269799.Gmet_3041 1.436e-65 239.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2WKPM@28221|Deltaproteobacteria,43TYK@69541|Desulfuromonadales 28221|Deltaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase ndh2 - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_5973006_0 266117.Rxyl_0724 7.367e-84 287.0 COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,4CQ48@84995|Rubrobacteria 84995|Rubrobacteria S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase CMS1_k127_5973006_2 1045855.DSC_07395 9.552e-41 156.0 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,1S2N9@1236|Gammaproteobacteria,1X6DC@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran CMS1_k127_5974857_0 443143.GM18_0105 1.411e-115 385.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42QGH@68525|delta/epsilon subdivisions,2WKTM@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM multicopper oxidase type 2 - - - - - - - - - - - - Cu-oxidase_2 CMS1_k127_5974857_3 290397.Adeh_3210 9.574e-52 184.0 COG4737@1|root,COG4737@2|Bacteria 2|Bacteria G Cytotoxic translational repressor of toxin-antitoxin stability system higB-2 - - - - - - - - - - - RelE CMS1_k127_5974857_4 290397.Adeh_3209 2.773e-43 166.0 COG2944@1|root,COG2944@2|Bacteria 2|Bacteria K sequence-specific DNA binding higA-2 - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3,HTH_31 CMS1_k127_5974857_6 314230.DSM3645_27533 1.324e-33 134.0 2E4CE@1|root,32Z7W@2|Bacteria 2|Bacteria S SMI1-KNR4 cell-wall - - - - - - - - - - - - SMI1_KNR4,SUKH_5,SUKH_6 CMS1_k127_5974857_1 1278073.MYSTI_01975 2.992e-106 359.0 COG0582@1|root,COG0582@2|Bacteria 2|Bacteria L DNA integration - - - - - - - - - - - - Phage_int_SAM_3,Phage_int_SAM_4,Phage_integrase CMS1_k127_5974857_7 909613.UO65_0089 4.239e-11 75.0 COG0582@1|root,COG0582@2|Bacteria,2I4FW@201174|Actinobacteria,4DXYY@85010|Pseudonocardiales 201174|Actinobacteria L viral genome integration into host DNA - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase CMS1_k127_5974857_2 1278073.MYSTI_01975 4.816e-71 248.0 COG0582@1|root,COG0582@2|Bacteria 2|Bacteria L DNA integration - - - - - - - - - - - - Phage_int_SAM_3,Phage_int_SAM_4,Phage_integrase CMS1_k127_5987165_1 926690.KE386573_gene2065 5.824e-32 133.0 COG1893@1|root,arCOG04139@2157|Archaea,2XTBD@28890|Euryarchaeota,23T98@183963|Halobacteria 183963|Halobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C CMS1_k127_5987165_3 880073.Calab_3215 6.269e-12 80.0 COG0366@1|root,COG0708@1|root,COG0366@2|Bacteria,COG0708@2|Bacteria,2NREA@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolase family 70 - - 3.1.11.2,3.2.1.1 ko:K01142,ko:K01176 ko00500,ko01100,ko03410,ko04973,map00500,map01100,map03410,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000,ko03400 - GH13 - Alpha-amylase,CBM_25,DUF1939,He_PIG CMS1_k127_5987165_2 1198114.AciX9_2489 1.822e-30 141.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity wcoG - - - - - - - - - - - DUF5122,Laminin_G_3,PKD CMS1_k127_5987165_0 1379698.RBG1_1C00001G0516 1.942e-87 294.0 COG0473@1|root,COG0473@2|Bacteria,2NP1R@2323|unclassified Bacteria 2|Bacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS1_k127_6004518_0 1379698.RBG1_1C00001G0112 3.682e-59 210.0 2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - CMS1_k127_6004518_2 1121090.KB894691_gene2590 2.098e-15 86.0 COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,4HABG@91061|Bacilli,1ZBG2@1386|Bacillus 91061|Bacilli H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation lipM GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB CMS1_k127_6004518_1 879212.DespoDRAFT_03007 8.084e-27 111.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2WJ66@28221|Deltaproteobacteria,2MIE2@213118|Desulfobacterales 28221|Deltaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N CMS1_k127_6012042_4 1121439.dsat_0613 0.0008497 52.0 COG2982@1|root,COG2982@2|Bacteria,1QA6E@1224|Proteobacteria,42PKZ@68525|delta/epsilon subdivisions,2WIQZ@28221|Deltaproteobacteria,2MACK@213115|Desulfovibrionales 28221|Deltaproteobacteria M AsmA-like C-terminal region - - - ko:K07289 - - - - ko00000 - - - AsmA,AsmA_2 CMS1_k127_6012042_1 235909.GK3168 2.011e-99 337.0 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,4HD4F@91061|Bacilli,1WGDJ@129337|Geobacillus 91061|Bacilli E DegT/DnrJ/EryC1/StrS aminotransferase family degT - - - - - - - - - - - DegT_DnrJ_EryC1 CMS1_k127_6012042_0 251221.35211608 5.34e-155 509.0 COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria 1117|Cyanobacteria O Belongs to the deoxyhypusine synthase family - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS CMS1_k127_6012042_2 1267535.KB906767_gene2483 4.061e-44 172.0 COG1028@1|root,COG1028@2|Bacteria,3Y822@57723|Acidobacteria 57723|Acidobacteria IQ NAD dependent epimerase/dehydratase family - - - - - - - - - - - - adh_short CMS1_k127_6012042_3 309807.SRU_2566 6.08e-27 125.0 COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,1FJBA@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Oxygen tolerance - - - - - - - - - - - - BatD CMS1_k127_6012394_0 1173026.Glo7428_3072 2.22e-115 392.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1G0P4@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg CMS1_k127_6025164_2 1410634.JHVD01000001_gene1598 3.577e-25 108.0 COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4DNPS@85009|Propionibacteriales 201174|Actinobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 CMS1_k127_6025164_3 886293.Sinac_3025 2.229e-20 100.0 COG1186@1|root,COG1186@2|Bacteria,2J05G@203682|Planctomycetes 203682|Planctomycetes J chain release factor - - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 CMS1_k127_6025164_1 926561.KB900620_gene2912 1.316e-70 264.0 COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia 186801|Clostridia E Family 5 - - - ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 CMS1_k127_6025164_0 671143.DAMO_2120 1.2e-90 326.0 COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2NQ9F@2323|unclassified Bacteria 2|Bacteria T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg CMS1_k127_6034455_1 324602.Caur_3182 1.671e-109 365.0 COG1640@1|root,COG1640@2|Bacteria,2G668@200795|Chloroflexi,376Q1@32061|Chloroflexia 32061|Chloroflexia G PFAM glycoside hydrolase, family 77 - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 CMS1_k127_6034455_0 1304874.JAFY01000002_gene747 1.703e-123 407.0 COG1172@1|root,COG1172@2|Bacteria,3TAA3@508458|Synergistetes 508458|Synergistetes G Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 CMS1_k127_6034455_2 1219084.AP014508_gene1118 1.684e-104 348.0 COG1172@1|root,COG1172@2|Bacteria,2GDW6@200918|Thermotogae 200918|Thermotogae U Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 CMS1_k127_6047069_1 224911.27355297 4.291e-34 138.0 COG0642@1|root,COG0784@1|root,COG3447@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3447@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3JW8Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,dCache_1 CMS1_k127_6047069_0 1121920.AUAU01000008_gene1626 1.066e-59 216.0 COG2197@1|root,COG2197@2|Bacteria,3Y7XN@57723|Acidobacteria 57723|Acidobacteria KT helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg CMS1_k127_6054318_0 235909.GK3010 9.428e-73 255.0 COG0506@1|root,COG0506@2|Bacteria,1TQV3@1239|Firmicutes,4HAC1@91061|Bacilli,1WFGP@129337|Geobacillus 91061|Bacilli E Proline dehydrogenase fadM GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh CMS1_k127_6054318_1 1279009.ADICEAN_02760 2.091e-36 143.0 COG2318@1|root,COG2318@2|Bacteria,4NRAP@976|Bacteroidetes,47NZT@768503|Cytophagia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_6054318_2 926560.KE387027_gene533 5.44e-26 117.0 COG2062@1|root,COG2062@2|Bacteria,1WN47@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T phosphohistidine phosphatase, SixA - - - - - - - - - - - - - CMS1_k127_6054318_3 1379698.RBG1_1C00001G0796 0.0002207 45.0 COG1956@1|root,COG1956@2|Bacteria 2|Bacteria T GAF domain-containing protein yebR - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF,GAF_2 CMS1_k127_6060550_3 644966.Tmar_0137 2.276e-73 279.0 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,3WCEP@538999|Clostridiales incertae sedis 186801|Clostridia E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic CMS1_k127_6060550_2 572477.Alvin_1128 5.946e-81 296.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales 135613|Chromatiales L Helicase - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2 CMS1_k127_6060550_0 869210.Marky_1927 3.345e-190 608.0 COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E COG0076 Glutamate decarboxylase and related PLP-dependent - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC CMS1_k127_6060550_1 926560.KE387027_gene263 3.278e-82 282.0 COG2120@1|root,COG2120@2|Bacteria 2|Bacteria S N-acetylglucosaminylinositol deacetylase activity - - - ko:K22135 - - - - ko00000,ko01000 - - - PIG-L CMS1_k127_6074646_1 1121439.dsat_2438 1.371e-27 129.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2M7S0@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM response regulator receiver phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C CMS1_k127_6074646_0 635013.TherJR_2511 6.245e-43 168.0 COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,260QX@186807|Peptococcaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - CHASE4,GGDEF,HD,HD_5,PAS,PAS_4,PAS_9,dCache_1 CMS1_k127_60827_1 909663.KI867151_gene3008 1.596e-106 368.0 COG0463@1|root,COG0463@2|Bacteria,1R547@1224|Proteobacteria,42PDC@68525|delta/epsilon subdivisions,2WKYW@28221|Deltaproteobacteria,2MR35@213462|Syntrophobacterales 28221|Deltaproteobacteria M glycosyl transferase family 2 - - 2.4.1.268 ko:K21349 - - - - ko00000,ko01000 - GT81 - Glycos_transf_2 CMS1_k127_60827_2 1411123.JQNH01000001_gene661 2.026e-88 303.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.20 ko:K05816 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.3 - - ABC_tran,TOBE_2 CMS1_k127_60827_4 1173024.KI912151_gene1868 4.379e-72 269.0 COG0395@1|root,COG0395@2|Bacteria,1G0CF@1117|Cyanobacteria,1JJRB@1189|Stigonemataceae 1117|Cyanobacteria G Binding-protein-dependent transport system inner membrane component ugpE - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 CMS1_k127_60827_3 118163.Ple7327_0810 5.344e-83 302.0 COG1175@1|root,COG1175@2|Bacteria,1G0YN@1117|Cyanobacteria,3VI3Y@52604|Pleurocapsales 1117|Cyanobacteria G PFAM Binding-protein-dependent transport system inner membrane component ugpA - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 CMS1_k127_60827_0 1173024.KI912151_gene1870 2.298e-119 407.0 COG1653@1|root,COG1653@2|Bacteria,1G0AA@1117|Cyanobacteria,1JJ8D@1189|Stigonemataceae 1117|Cyanobacteria G Bacterial extracellular solute-binding protein ugpB - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 CMS1_k127_60827_5 290397.Adeh_4065 3.51e-14 79.0 COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,42MF3@68525|delta/epsilon subdivisions,2WJXS@28221|Deltaproteobacteria,2YVQQ@29|Myxococcales 28221|Deltaproteobacteria G Class II Aldolase and Adducin N-terminal domain - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II CMS1_k127_6112576_1 671143.DAMO_0264 5.669e-47 185.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2NP0Q@2323|unclassified Bacteria 2|Bacteria M Bacterial sugar transferase wcaJ - - ko:K03606,ko:K20997 ko02025,ko05111,map02025,map05111 - - - ko00000,ko00001 - - - Bac_transf,CoA_binding_3 CMS1_k127_6112576_0 374847.Kcr_0841 1.68e-70 256.0 arCOG03850@1|root,arCOG03850@2157|Archaea 2157|Archaea S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 CMS1_k127_6112576_3 1445613.JALM01000020_gene4744 6.853e-09 68.0 2AWQM@1|root,31NMJ@2|Bacteria,2HR6F@201174|Actinobacteria,4EAA3@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_6112576_2 1267535.KB906767_gene1690 4.226e-40 164.0 COG3206@1|root,COG3206@2|Bacteria,3Y31V@57723|Acidobacteria,2JIKV@204432|Acidobacteriia 204432|Acidobacteriia M G-rich domain on putative tyrosine kinase - - - - - - - - - - - - GNVR,Wzz CMS1_k127_6112576_4 1340493.JNIF01000003_gene3926 8.634e-07 55.0 COG3307@1|root,COG3307@2|Bacteria 2|Bacteria M -O-antigen - - - - - - - - - - - - Wzy_C CMS1_k127_6178073_1 1123257.AUFV01000006_gene366 6.914e-22 109.0 COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,1RY3C@1236|Gammaproteobacteria,1X4KQ@135614|Xanthomonadales 135614|Xanthomonadales S Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM CMS1_k127_6178073_0 1267533.KB906733_gene3420 2.51e-67 235.0 COG0412@1|root,COG0412@2|Bacteria,3Y4P0@57723|Acidobacteria,2JJCI@204432|Acidobacteriia 204432|Acidobacteriia Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH CMS1_k127_6180312_0 742722.HMPREF9463_01621 3.357e-89 309.0 COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4CUS0@84998|Coriobacteriia 84998|Coriobacteriia H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein CMS1_k127_6180312_1 868864.Dester_0178 1.231e-56 203.0 COG0194@1|root,COG0194@2|Bacteria,2G3ZQ@200783|Aquificae 200783|Aquificae F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin CMS1_k127_6193551_0 1382359.JIAL01000001_gene1745 3.552e-88 301.0 COG0612@1|root,COG0612@2|Bacteria,3Y2UB@57723|Acidobacteria,2JITC@204432|Acidobacteriia 204432|Acidobacteriia S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_6193551_1 379066.GAU_3352 6.576e-50 183.0 COG1528@1|root,COG1528@2|Bacteria,1ZUFX@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Rubrerythrin - - 1.16.3.1 ko:K22336 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin CMS1_k127_6218096_3 1122138.AQUZ01000040_gene6199 0.0001588 54.0 COG0382@1|root,COG0382@2|Bacteria,2IJV5@201174|Actinobacteria 201174|Actinobacteria H UbiA prenyltransferase family - - 2.5.1.133,2.5.1.62 ko:K04040 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06284,R09067,R11514,R11517 RC00020 ko00000,ko00001,ko01000,ko01006 - - - UbiA CMS1_k127_6218096_2 1158292.JPOE01000002_gene3152 2.307e-33 144.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,1KKPX@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) rfaF - - ko:K02841,ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 CMS1_k127_6218096_0 234267.Acid_5166 5.988e-168 542.0 COG0156@1|root,COG0156@2|Bacteria,3Y3J2@57723|Acidobacteria 57723|Acidobacteria E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide - - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_6218096_1 1382359.JIAL01000001_gene1783 1.007e-39 151.0 COG1063@1|root,COG1063@2|Bacteria,3Y3KU@57723|Acidobacteria,2JIQ4@204432|Acidobacteriia 204432|Acidobacteriia C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_6270163_0 349124.Hhal_0421 4.712e-15 79.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 CMS1_k127_6270163_2 864069.MicloDRAFT_00009600 1.842e-05 54.0 COG3415@1|root,COG3415@2|Bacteria 2|Bacteria L Transposase - - - ko:K01152 - - - - ko00000 - - - DDE_3,HTH_23,HTH_Tnp_IS630 CMS1_k127_6270163_1 335543.Sfum_2298 1.596e-05 55.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MRYH@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_11,TPR_12,TPR_16,TPR_2,TPR_4,TPR_8 CMS1_k127_627472_1 1321774.HMPREF9108_01750 3.015e-22 106.0 COG0811@1|root,COG0811@2|Bacteria,379FS@32066|Fusobacteria 32066|Fusobacteria U Transporter, MotA TolQ ExbB proton channel family protein - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB CMS1_k127_627472_4 397945.Aave_4551 3.125e-05 52.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSMV@28216|Betaproteobacteria,4AEE0@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD CMS1_k127_627472_2 614083.AWQR01000009_gene615 2.255e-14 79.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSMV@28216|Betaproteobacteria,4AEE0@80864|Comamonadaceae 28216|Betaproteobacteria U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD CMS1_k127_627472_5 314282.PCNPT3_12075 0.0004723 52.0 COG0810@1|root,COG0810@2|Bacteria,1NH16@1224|Proteobacteria 1224|Proteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C CMS1_k127_627472_3 665571.STHERM_c10790 4.651e-07 62.0 COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes 203691|Spirochaetes M ompA family - - - - - - - - - - - - Big_3_3,CHU_C,FlgD_ig,OmpA CMS1_k127_627472_0 1123508.JH636449_gene7358 1.183e-50 192.0 COG0380@1|root,COG0380@2|Bacteria,2IYNH@203682|Planctomycetes 203682|Planctomycetes G Glycosyltransferase family 20 - - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20 CMS1_k127_641623_4 404589.Anae109_2043 8.461e-13 70.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2YXF9@29|Myxococcales 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 CMS1_k127_641623_1 251221.35212830 4.381e-156 507.0 COG3104@1|root,COG3104@2|Bacteria 2|Bacteria E oligopeptide transport dtpT - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 CMS1_k127_641623_2 404589.Anae109_2045 9.727e-72 251.0 COG0576@1|root,COG0576@2|Bacteria,1QAQQ@1224|Proteobacteria,4358N@68525|delta/epsilon subdivisions,2WZJT@28221|Deltaproteobacteria,2Z2A4@29|Myxococcales 28221|Deltaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ - - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE CMS1_k127_641623_0 290397.Adeh_1771 1.489e-212 672.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS1_k127_641623_3 1444711.CCJF01000005_gene546 5.284e-32 146.0 COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_5,Calx-beta,SBBP CMS1_k127_64702_0 646529.Desaci_1209 5.271e-121 401.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,260F2@186807|Peptococcaceae 186801|Clostridia L PFAM UvrD REP helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C CMS1_k127_64702_1 909663.KI867149_gene3374 1.321e-05 56.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,42PSZ@68525|delta/epsilon subdivisions,2WMBH@28221|Deltaproteobacteria,2MRBB@213462|Syntrophobacterales 28221|Deltaproteobacteria S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB CMS1_k127_657773_1 1206725.BAFU01000219_gene11 2.83e-32 131.0 COG3415@1|root,COG3415@2|Bacteria,2IJ9E@201174|Actinobacteria 201174|Actinobacteria L Winged helix-turn helix - - - - - - - - - - - - HTH_29,HTH_32,HTH_33 CMS1_k127_657773_2 66429.JOFL01000024_gene5986 1.03e-27 125.0 COG3335@1|root,COG3335@2|Bacteria,2I9RW@201174|Actinobacteria 201174|Actinobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 CMS1_k127_657773_0 1304880.JAGB01000001_gene680 2.16e-44 171.0 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia 186801|Clostridia KLT serine threonine protein kinase prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase CMS1_k127_65882_1 344747.PM8797T_31980 7.085e-07 62.0 COG5183@1|root,COG5183@2|Bacteria,2IY9V@203682|Planctomycetes 203682|Planctomycetes A protein ubiquitination - - - - - - - - - - - - - CMS1_k127_65882_0 518766.Rmar_0129 7.167e-50 181.0 COG1657@1|root,COG1657@2|Bacteria,4NFMT@976|Bacteroidetes,1FJ7Y@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 CMS1_k127_670403_0 1121422.AUMW01000056_gene42 1.023e-168 556.0 COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,260KE@186807|Peptococcaceae 186801|Clostridia Q Multicopper oxidase - - 1.16.3.3 ko:K06324 - - - - ko00000,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_670403_1 204669.Acid345_0280 2.13e-122 401.0 COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,3Y7G5@57723|Acidobacteria 57723|Acidobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N CMS1_k127_688109_0 1384054.N790_09665 7.024e-127 415.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1X5QJ@135614|Xanthomonadales 135614|Xanthomonadales E Cys/Met metabolism PLP-dependent enzyme - - 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP CMS1_k127_688109_3 1121946.AUAX01000016_gene4690 1.697e-29 130.0 COG2020@1|root,COG2020@2|Bacteria,2IP2M@201174|Actinobacteria,4DGDW@85008|Micromonosporales 201174|Actinobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT CMS1_k127_688109_2 204669.Acid345_4043 1.563e-68 257.0 COG1680@1|root,COG1680@2|Bacteria,3Y7SG@57723|Acidobacteria,2JMWV@204432|Acidobacteriia 204432|Acidobacteriia V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_688109_1 1210884.HG799466_gene13015 3.557e-86 299.0 COG0053@1|root,COG0053@2|Bacteria,2IY05@203682|Planctomycetes 203682|Planctomycetes P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer CMS1_k127_701918_1 1267533.KB906739_gene2658 1.169e-80 295.0 COG1132@1|root,COG1132@2|Bacteria,3Y2ZR@57723|Acidobacteria,2JHJA@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter, transmembrane - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran CMS1_k127_701918_0 867903.ThesuDRAFT_01558 4.251e-92 316.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WCV1@538999|Clostridiales incertae sedis 186801|Clostridia V ABC-type multidrug transport system ATPase and permease - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran CMS1_k127_705448_2 580327.Tthe_1754 7.243e-31 126.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales 186801|Clostridia K Response regulator receiver phoP - - ko:K02483,ko:K07658,ko:K07668 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C CMS1_k127_705448_0 643473.KB235930_gene4490 2.05e-145 475.0 COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1G0T4@1117|Cyanobacteria,1HM63@1161|Nostocales 1117|Cyanobacteria EK Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP CMS1_k127_705448_1 1379270.AUXF01000003_gene3495 1.88e-42 176.0 COG0626@1|root,COG0626@2|Bacteria,1ZT9F@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.1 ko:K01758 ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230 M00338 R00782,R01001,R02408,R04770,R04930,R09366 RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP CMS1_k127_713217_1 861299.J421_2148 1.281e-05 53.0 COG3748@1|root,COG3748@2|Bacteria 2|Bacteria S Urate oxidase N-terminal MA20_17625 - - - - - - - - - - - PSCyt1,Urate_ox_N CMS1_k127_713217_0 1121920.AUAU01000004_gene719 7.927e-184 601.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria 57723|Acidobacteria KLTU Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40,Pkinase CMS1_k127_714095_1 1379270.AUXF01000002_gene1191 1.893e-64 235.0 COG0592@1|root,COG0592@2|Bacteria,1ZT22@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_3 CMS1_k127_714095_0 1121091.AUMP01000002_gene2146 1.42e-147 478.0 COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,4HBUQ@91061|Bacilli 91061|Bacilli E aminopeptidase pepS - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 CMS1_k127_714095_2 1122614.JHZF01000011_gene678 3.36e-40 151.0 COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,2U768@28211|Alphaproteobacteria,2PECR@252301|Oceanicola 28211|Alphaproteobacteria O OsmC-like protein osmC GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 - ko:K04063 - - - - ko00000 - - - OsmC CMS1_k127_722251_2 319225.Plut_0571 2.451e-27 115.0 COG0768@1|root,COG0768@2|Bacteria,1FD7D@1090|Chlorobi 1090|Chlorobi M PFAM penicillin-binding protein transpeptidase - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase CMS1_k127_722251_0 1379698.RBG1_1C00001G1004 2.354e-97 336.0 COG0772@1|root,COG0772@2|Bacteria,2NNRP@2323|unclassified Bacteria 2|Bacteria D Peptidoglycan polymerase that is essential for cell wall elongation rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE CMS1_k127_722251_1 1379698.RBG1_1C00001G1006 3.889e-48 195.0 COG0682@1|root,COG0682@2|Bacteria,2NPK2@2323|unclassified Bacteria 2|Bacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT CMS1_k127_723389_1 429009.Adeg_1192 3.022e-50 181.0 COG1064@1|root,COG1064@2|Bacteria,1TP5B@1239|Firmicutes,24GKF@186801|Clostridia,42HT2@68295|Thermoanaerobacterales 186801|Clostridia C TIGRFAM zinc-binding alcohol dehydrogenase family protein - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_723389_0 1125863.JAFN01000001_gene2446 1.077e-62 225.0 COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,42NZQ@68525|delta/epsilon subdivisions,2WMCW@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.100 ko:K07537 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05597 RC03168 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_723389_2 1267535.KB906767_gene4685 2.602e-32 134.0 COG1305@1|root,COG1305@2|Bacteria,3Y2TK@57723|Acidobacteria,2JHX7@204432|Acidobacteriia 204432|Acidobacteriia E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core CMS1_k127_730869_1 760568.Desku_2843 4.818e-275 863.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae 186801|Clostridia H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS1_k127_730869_0 483219.LILAB_22395 0.0 1212.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA1 - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC CMS1_k127_730869_3 404380.Gbem_2248 1.737e-07 61.0 COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,42Y44@68525|delta/epsilon subdivisions,2WT88@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Membrane - - - - - - - - - - - - - CMS1_k127_730869_2 290397.Adeh_2046 1.689e-48 182.0 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,42TIP@68525|delta/epsilon subdivisions,2WQA8@28221|Deltaproteobacteria,2YZB0@29|Myxococcales 28221|Deltaproteobacteria U UPF0056 inner membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC CMS1_k127_750660_1 1379698.RBG1_1C00001G0700 2.577e-170 538.0 COG0427@1|root,COG0427@2|Bacteria,2NQDP@2323|unclassified Bacteria 2|Bacteria C Acetyl-CoA hydrolase/transferase N-terminal domain - - 3.1.2.1 ko:K01067 ko00620,map00620 - R00227 RC00004,RC00012 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro CMS1_k127_750660_0 1499967.BAYZ01000081_gene1057 8.835e-214 679.0 COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria 2|Bacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gluD GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.gdhA ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_762620_1 595460.RRSWK_04121 2.204e-14 75.0 COG3250@1|root,COG3507@1|root,COG3250@2|Bacteria,COG3507@2|Bacteria,2IWTW@203682|Planctomycetes 203682|Planctomycetes G Glycosyl hydrolases family 2 - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Glyco_hydro_43 CMS1_k127_762620_0 1144275.COCOR_02903 2.599e-146 476.0 COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,42SM7@68525|delta/epsilon subdivisions,2WP5E@28221|Deltaproteobacteria,2YYGZ@29|Myxococcales 28221|Deltaproteobacteria G Converts alpha-aldose to the beta-anomer galM2 - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim CMS1_k127_762620_2 379066.GAU_0426 3.108e-08 58.0 COG0477@1|root,COG2814@2|Bacteria,1ZT84@142182|Gemmatimonadetes 142182|Gemmatimonadetes EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr CMS1_k127_771178_1 1366050.N234_16795 1.616e-40 151.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria,1K38F@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase CMS1_k127_771178_0 1183438.GKIL_4041 9.327e-65 237.0 COG0702@1|root,COG0702@2|Bacteria,1G3KV@1117|Cyanobacteria 1117|Cyanobacteria GM NmrA-like family - - - - - - - - - - - - NmrA CMS1_k127_771178_2 1005048.CFU_3650 5.885e-06 53.0 COG4313@1|root,COG4313@2|Bacteria,1R5Z9@1224|Proteobacteria,2VKTG@28216|Betaproteobacteria,477GC@75682|Oxalobacteraceae 28216|Betaproteobacteria C Protein involved in meta-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg CMS1_k127_775034_0 1379698.RBG1_1C00001G1724 1.365e-109 368.0 COG0845@1|root,COG0845@2|Bacteria,2NR7K@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mdtA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 CMS1_k127_775034_1 1379698.RBG1_1C00001G1725 6.344e-106 350.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran CMS1_k127_782236_2 264462.Bd1337 9.488e-32 128.0 COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,430NN@68525|delta/epsilon subdivisions,2MT6T@213481|Bdellovibrionales,2WVYS@28221|Deltaproteobacteria 213481|Bdellovibrionales B SWI complex, BAF60b domains - - - - - - - - - - - - SWIB CMS1_k127_782236_3 1347086.CCBA010000012_gene2030 1.206e-05 47.0 2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - CMS1_k127_782236_0 517418.Ctha_1672 5.834e-118 406.0 COG0297@1|root,COG0297@2|Bacteria,1FDT0@1090|Chlorobi 1090|Chlorobi F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 CMS1_k127_782236_1 290397.Adeh_0134 1.526e-62 220.0 COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2WKT8@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM galactose-1-phosphate uridylyltransferase galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - DUF4921,GalP_UDP_tr_C,GalP_UDP_transf CMS1_k127_83431_6 1267535.KB906767_gene2774 1.723e-05 51.0 COG1714@1|root,COG1714@2|Bacteria 2|Bacteria S RDD family - - - - - - - - - - - - GPDPase_memb,RDD CMS1_k127_83431_0 237368.SCABRO_01842 6.782e-35 139.0 COG1047@1|root,COG1047@2|Bacteria,2J1AR@203682|Planctomycetes 203682|Planctomycetes O FKBP-type peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C CMS1_k127_83431_5 1142394.PSMK_15110 2.167e-09 69.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process - - - - - - - - - - - - Peptidase_MA_2 CMS1_k127_83431_1 234267.Acid_3487 1.014e-29 126.0 COG0526@1|root,COG0526@2|Bacteria,3Y5DD@57723|Acidobacteria 57723|Acidobacteria CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA CMS1_k127_83431_2 1232410.KI421413_gene750 7.281e-24 119.0 COG2885@1|root,COG3210@1|root,COG5184@1|root,COG5276@1|root,COG2885@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria,1QUHA@1224|Proteobacteria,42VF6@68525|delta/epsilon subdivisions,2WR7F@28221|Deltaproteobacteria 28221|Deltaproteobacteria DZ Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 CMS1_k127_83431_7 1120965.AUBV01000009_gene2972 6.391e-05 57.0 COG3209@1|root,COG3291@1|root,COG3391@1|root,COG5184@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CHU_C,PKD CMS1_k127_83431_4 103733.JNYO01000076_gene6416 7.867e-10 73.0 COG2931@1|root,COG4447@1|root,COG2931@2|Bacteria,COG4447@2|Bacteria,2HSAI@201174|Actinobacteria,4ED2E@85010|Pseudonocardiales 201174|Actinobacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - - CMS1_k127_83431_3 382464.ABSI01000007_gene4197 6.655e-23 116.0 COG4625@1|root,COG4625@2|Bacteria,46WKK@74201|Verrucomicrobia,2IWCX@203494|Verrucomicrobiae 203494|Verrucomicrobiae S pathogenesis - - - - - - - - - - - - - CMS1_k127_8837_0 441769.ABFU01000028_gene1377 3.791e-29 117.0 COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,4HB89@91061|Bacilli,1ZAWM@1386|Bacillus 91061|Bacilli D Required for chromosome condensation and partitioning smc GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge CMS1_k127_8837_1 765869.BDW_12230 1.676e-05 57.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,437H8@68525|delta/epsilon subdivisions,2MTC0@213481|Bdellovibrionales,2X2QR@28221|Deltaproteobacteria 213481|Bdellovibrionales D Sporulation related domain - - - - - - - - - - - - SPOR CMS1_k127_89330_0 204669.Acid345_3369 1.842e-98 357.0 COG0515@1|root,COG0515@2|Bacteria 204669.Acid345_3369|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_89330_3 42256.RradSPS_2174 3.519e-11 76.0 COG0730@1|root,COG0730@2|Bacteria,2GNW8@201174|Actinobacteria,4CRVC@84995|Rubrobacteria 84995|Rubrobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_89330_1 521045.Kole_1995 4.549e-53 203.0 COG1649@1|root,COG1649@2|Bacteria,2GCSB@200918|Thermotogae 200918|Thermotogae S Glycosyl hydrolase-like 10 - - - - - - - - - - - - GHL10 CMS1_k127_89330_2 1235797.C816_00689 7.848e-12 70.0 COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,2N7EF@216572|Oscillospiraceae 186801|Clostridia J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 CMS1_k127_902620_1 861299.J421_4251 3.239e-39 160.0 COG0438@1|root,COG0438@2|Bacteria,1ZV6E@142182|Gemmatimonadetes 142182|Gemmatimonadetes M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - CMS1_k127_902620_0 324925.Ppha_0260 5.571e-87 321.0 COG5617@1|root,COG5617@2|Bacteria,1FDV6@1090|Chlorobi 1090|Chlorobi S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - YfhO CMS1_k127_906088_0 96561.Dole_1542 0.0001612 54.0 COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - PMT_2,TPR_2 CMS1_k127_907483_1 635013.TherJR_2972 9.452e-98 329.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,260E3@186807|Peptococcaceae 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C CMS1_k127_907483_3 1379698.RBG1_1C00001G0978 2.436e-68 254.0 COG0767@1|root,COG0767@2|Bacteria,2NPFZ@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS1_k127_907483_2 1379698.RBG1_1C00001G0979 5.074e-85 289.0 COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, ATPase component mkl - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran CMS1_k127_907483_4 1297742.A176_00619 4.269e-16 90.0 COG1463@1|root,COG1463@2|Bacteria,1QTED@1224|Proteobacteria,437WX@68525|delta/epsilon subdivisions,2WWP6@28221|Deltaproteobacteria,2YVFU@29|Myxococcales 28221|Deltaproteobacteria Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS1_k127_907483_0 292459.STH3128 3.239e-131 430.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia 186801|Clostridia O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C CMS1_k127_910160_2 290397.Adeh_2849 2.677e-46 187.0 COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,42MGR@68525|delta/epsilon subdivisions,2X5KV@28221|Deltaproteobacteria,2YY40@29|Myxococcales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_910160_3 247490.KSU1_C1124 1.855e-19 104.0 COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,2IZWB@203682|Planctomycetes 203682|Planctomycetes K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N CMS1_k127_910160_0 1379698.RBG1_1C00001G0818 8.424e-70 243.0 COG0605@1|root,COG0605@2|Bacteria,2NP62@2323|unclassified Bacteria 2|Bacteria P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodA GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010269,GO:0010447,GO:0016020,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0020012,GO:0030145,GO:0030682,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052059,GO:0052173,GO:0052200,GO:0052385,GO:0052550,GO:0052564,GO:0052567,GO:0052572,GO:0055114,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071291,GO:0071450,GO:0071451,GO:0071944,GO:0072593,GO:0075136,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 ko:K03601,ko:K04564 ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000,ko03400 - - iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iE2348C_1286.E2348C_4213,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSF_1327.ECSF_3769,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNJ661.Rv3846,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050 Sod_Fe_C,Sod_Fe_N CMS1_k127_910160_4 616991.JPOO01000003_gene109 3.268e-08 63.0 2CK2Q@1|root,303GN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_910160_1 1394178.AWOO02000018_gene6617 4.142e-53 195.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4EGQ9@85012|Streptosporangiales 201174|Actinobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_921922_2 1303518.CCALI_00819 1.607e-31 129.0 COG0316@1|root,COG0316@2|Bacteria 2|Bacteria S protein maturation - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn CMS1_k127_921922_3 857087.Metme_1234 3.363e-12 71.0 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1SAAA@1236|Gammaproteobacteria,1XFCJ@135618|Methylococcales 135618|Methylococcales P Rieske 2Fe-2S - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske CMS1_k127_921922_0 1287116.X734_16505 1.369e-94 325.0 COG0520@1|root,COG0520@2|Bacteria,1RB0A@1224|Proteobacteria,2VFZ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5,DegT_DnrJ_EryC1 CMS1_k127_921922_1 96561.Dole_0855 2.197e-37 147.0 COG0490@1|root,COG1226@1|root,COG4651@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,2MHVK@213118|Desulfobacterales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.2 - - Na_H_Exchanger,TrkA_C,TrkA_N CMS1_k127_932535_0 204669.Acid345_0280 1.235e-253 801.0 COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,3Y7G5@57723|Acidobacteria 57723|Acidobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N CMS1_k127_932535_1 204669.Acid345_0942 2.822e-98 323.0 COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia 2|Bacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_934471_2 1049564.TevJSym_ac00600 1.463e-49 182.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain - - 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 - - Cyt_bd_oxida_I,Cytochrome_CBB3 CMS1_k127_934471_3 247490.KSU1_B0267 1.759e-18 97.0 COG2010@1|root,COG2010@2|Bacteria,2IXPN@203682|Planctomycetes 203682|Planctomycetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C CMS1_k127_934471_1 1049564.TevJSym_ac00580 3.163e-51 192.0 COG2010@1|root,COG2010@2|Bacteria,1R28S@1224|Proteobacteria,1T5JD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 CMS1_k127_934471_0 1379698.RBG1_1C00001G0011 1.042e-66 251.0 COG2010@1|root,COG2180@1|root,COG2010@2|Bacteria,COG2180@2|Bacteria,2NR8D@2323|unclassified Bacteria 2|Bacteria C Cytochrome c narJ GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - ko:K00373,ko:K00405,ko:K17052 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko02000 3.D.4.3,5.A.3.8 - iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687 Nitrate_red_del CMS1_k127_934471_4 1144275.COCOR_04733 2.473e-10 66.0 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,42XVI@68525|delta/epsilon subdivisions,2WTER@28221|Deltaproteobacteria,2YX2W@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C,Cytochrome_CBB3 CMS1_k127_934471_5 1313421.JHBV01000016_gene5568 4.698e-07 52.0 COG1622@1|root,COG1622@2|Bacteria,4NFNF@976|Bacteroidetes,1IPEE@117747|Sphingobacteriia 976|Bacteroidetes C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM CMS1_k127_936699_11 1340493.JNIF01000003_gene2492 2.621e-18 99.0 COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria 57723|Acidobacteria Q PFAM Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS1_k127_936699_3 1162668.LFE_1729 3.254e-61 220.0 COG1127@1|root,COG1127@2|Bacteria,3J12B@40117|Nitrospirae 40117|Nitrospirae Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran CMS1_k127_936699_7 861299.J421_3477 2.903e-45 174.0 COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS1_k127_936699_2 926569.ANT_14920 2.646e-65 244.0 COG3000@1|root,COG3000@2|Bacteria 2|Bacteria I iron ion binding - - - - - - - - - - - - FA_hydroxylase CMS1_k127_936699_10 1266908.AQPB01000034_gene666 6.685e-20 106.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WW37@135613|Chromatiales 135613|Chromatiales O Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM CMS1_k127_936699_6 1254432.SCE1572_46590 3.333e-48 179.0 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,437K2@68525|delta/epsilon subdivisions,2WW0X@28221|Deltaproteobacteria,2YVI7@29|Myxococcales 28221|Deltaproteobacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS CMS1_k127_936699_4 671143.DAMO_1166 2.356e-58 212.0 COG1622@1|root,COG1622@2|Bacteria,2NNSH@2323|unclassified Bacteria 2|Bacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C CMS1_k127_936699_0 671143.DAMO_1165 1.344e-220 705.0 COG0843@1|root,COG0843@2|Bacteria,2NNTQ@2323|unclassified Bacteria 2|Bacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxN GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 CMS1_k127_936699_5 382464.ABSI01000010_gene3667 2.723e-55 203.0 COG1845@1|root,COG1845@2|Bacteria,46SRD@74201|Verrucomicrobia,2IU4E@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome c oxidase subunit III - - - - - - - - - - - - COX3 CMS1_k127_936699_8 382464.ABSI01000010_gene3665 2.296e-30 128.0 COG1845@1|root,COG1845@2|Bacteria 2|Bacteria C cytochrome c oxidase, subunit III coxO - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 CMS1_k127_936699_12 246197.MXAN_0775 8.839e-07 61.0 COG0457@1|root,COG0457@2|Bacteria,1Q2MK@1224|Proteobacteria,43886@68525|delta/epsilon subdivisions,2X3HX@28221|Deltaproteobacteria,2YW6E@29|Myxococcales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_936699_1 1232410.KI421415_gene3092 5.227e-77 280.0 COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria,43SUB@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase CMS1_k127_936699_9 338963.Pcar_0770 5.046e-30 123.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,43RXT@69541|Desulfuromonadales 28221|Deltaproteobacteria H Ferrochelatase hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase CMS1_k127_939228_0 246194.CHY_0330 6.274e-278 876.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,42FKN@68295|Thermoanaerobacterales 186801|Clostridia O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C CMS1_k127_939228_1 1304888.ATWF01000001_gene2249 6.505e-95 325.0 COG0075@1|root,COG0075@2|Bacteria,2GEIZ@200930|Deferribacteres 200930|Deferribacteres E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS1_k127_939228_2 644966.Tmar_0517 1.577e-83 287.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,25F0C@186801|Clostridia,3WD52@538999|Clostridiales incertae sedis 186801|Clostridia CH PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - 1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95 ko:K00015,ko:K00058,ko:K16843 ko00260,ko00270,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00020 R00717,R01388,R01513,R05693 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT CMS1_k127_950894_0 1121104.AQXH01000002_gene548 6.11e-145 479.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS1_k127_95359_0 357808.RoseRS_0253 2.212e-110 364.0 COG0039@1|root,COG0039@2|Bacteria,2G61S@200795|Chloroflexi,374VR@32061|Chloroflexia 32061|Chloroflexia C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N CMS1_k127_95359_1 1379698.RBG1_1C00001G0440 1.637e-57 210.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS1_k127_95359_2 1122216.AUHW01000017_gene1167 6.243e-31 126.0 COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,4H20C@909932|Negativicutes 909932|Negativicutes M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 CMS1_k127_95625_1 1278073.MYSTI_05198 2.753e-19 103.0 COG0457@1|root,COG0457@2|Bacteria,1P92T@1224|Proteobacteria,4331J@68525|delta/epsilon subdivisions,2WYEN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_95625_0 330214.NIDE0751 3.043e-182 580.0 COG0017@1|root,COG0017@2|Bacteria 2|Bacteria J Asparaginyl-tRNA synthetase asnS GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon CMS1_k127_957284_0 290397.Adeh_3566 2.671e-131 438.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2YUGG@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS1_k127_957284_1 1510531.JQJJ01000009_gene670 1.055e-23 113.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2TTZ4@28211|Alphaproteobacteria,3JS77@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK CMS1_k127_96545_0 1532557.JL37_10635 5.939e-130 424.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,3T1UU@506|Alcaligenaceae 28216|Betaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N CMS1_k127_96545_1 518766.Rmar_2313 4.527e-32 136.0 COG0632@1|root,COG0632@2|Bacteria,4NF4E@976|Bacteroidetes,1FJ9Q@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N CMS1_k127_96545_2 1343158.SACS_1580 2.257e-11 67.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,2JS5T@204441|Rhodospirillales 204441|Rhodospirillales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC CMS1_k127_966520_0 1379698.RBG1_1C00001G0607 4.198e-133 447.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 CMS1_k127_966520_1 324602.Caur_1894 4.291e-15 76.0 COG2317@1|root,COG2317@2|Bacteria,2G7UQ@200795|Chloroflexi,37518@32061|Chloroflexia 32061|Chloroflexia E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 CMS1_k127_966669_1 1449080.JQMV01000003_gene839 8.601e-118 398.0 COG0457@1|root,COG0457@2|Bacteria,1WI5I@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_966669_2 1173028.ANKO01000116_gene5724 2.626e-42 173.0 COG0546@1|root,COG0546@2|Bacteria,1G6AW@1117|Cyanobacteria,1HCZI@1150|Oscillatoriales 1117|Cyanobacteria S haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 CMS1_k127_966669_0 1499967.BAYZ01000014_gene6372 1.107e-122 412.0 COG2805@1|root,COG2805@2|Bacteria 2|Bacteria NU Type II/IV secretion system protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS1_k127_973185_6 518766.Rmar_2194 4.911e-43 161.0 COG0160@1|root,COG0160@2|Bacteria,4NGPB@976|Bacteroidetes,1FITF@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lat - 2.6.1.36 ko:K03918 ko01100,map01100 - R00457 RC00006,RC00062 ko00000,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_973185_7 1068980.ARVW01000001_gene3281 7.544e-37 154.0 COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DYZC@85010|Pseudonocardiales 201174|Actinobacteria K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_973185_10 1396141.BATP01000044_gene1481 2.249e-20 108.0 COG4941@1|root,COG4941@2|Bacteria,46SEY@74201|Verrucomicrobia,2IV8H@203494|Verrucomicrobiae 203494|Verrucomicrobiae K Sigma-70 region 2 - - - - - - - - - - - - Sigma70_r2 CMS1_k127_973185_9 1379270.AUXF01000001_gene2271 7.939e-28 117.0 COG3795@1|root,COG3795@2|Bacteria,1ZV0M@142182|Gemmatimonadetes 142182|Gemmatimonadetes S YCII-related domain - - - - - - - - - - - - YCII CMS1_k127_973185_2 404589.Anae109_0137 1.292e-77 274.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WNXT@28221|Deltaproteobacteria,2YV4W@29|Myxococcales 28221|Deltaproteobacteria EGP of the major facilitator superfamily agmP - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1,MFS_1_like,Sugar_tr CMS1_k127_973185_4 1122139.KB907868_gene1267 1.036e-49 186.0 COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,1S9CM@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the DNA glycosylase MPG family - GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco CMS1_k127_973185_0 1047013.AQSP01000105_gene1455 2.652e-129 430.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_973185_5 1121447.JONL01000001_gene1050 2.81e-44 169.0 COG1225@1|root,COG1225@2|Bacteria,1N9JS@1224|Proteobacteria,42R82@68525|delta/epsilon subdivisions,2WMVA@28221|Deltaproteobacteria,2MBM6@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - AhpC-TSA CMS1_k127_973185_8 1189620.AJXL01000015_gene954 1.737e-30 134.0 28IIU@1|root,2Z8JV@2|Bacteria,4NEFH@976|Bacteroidetes,1IMXV@117743|Flavobacteriia,2NW5U@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_973185_3 1379698.RBG1_1C00001G1285 5.179e-55 203.0 COG1225@1|root,COG1225@2|Bacteria,2NPEE@2323|unclassified Bacteria 2|Bacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA CMS1_k127_973185_1 246194.CHY_1144 9.788e-119 399.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,42F1S@68295|Thermoanaerobacterales 186801|Clostridia G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C CMS1_k127_977245_6 1121920.AUAU01000017_gene1198 2.444e-46 173.0 arCOG11509@1|root,31KIR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_977245_4 247490.KSU1_D0842 3.97e-57 207.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_C_4,TetR_N CMS1_k127_977245_7 290315.Clim_1282 1.892e-16 94.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - ko:K12340,ko:K15725 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,1.B.17.2.2,2.A.6.2 - - OEP CMS1_k127_977245_3 1123368.AUIS01000024_gene946 4.782e-99 353.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RS3I@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Secretion protein yhiI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_977245_2 1123368.AUIS01000024_gene947 2.988e-117 403.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NDPN@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_977245_1 1123368.AUIS01000024_gene948 1.555e-137 460.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NCCI@225057|Acidithiobacillales 225057|Acidithiobacillales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 CMS1_k127_977245_0 1123368.AUIS01000024_gene949 1.342e-160 520.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,2NBU9@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS1_k127_977245_5 1123368.AUIS01000024_gene950 8.594e-50 197.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS1_k127_978040_1 1246448.ANAZ01000010_gene3238 2.889e-71 248.0 COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4EFJ5@85012|Streptosporangiales 201174|Actinobacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N CMS1_k127_978040_0 1382304.JNIL01000001_gene992 6.408e-123 417.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,2784A@186823|Alicyclobacillaceae 91061|Bacilli I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_978040_2 502025.Hoch_0124 8.667e-64 242.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2YTZB@29|Myxococcales 28221|Deltaproteobacteria E synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like CMS1_k127_981399_0 1379698.RBG1_1C00001G1305 1.448e-299 946.0 COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S dicluster domain actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molydop_binding CMS1_k127_981399_1 1379698.RBG1_1C00001G1304 3.496e-44 172.0 COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria 2|Bacteria C Polysulphide reductase, NrfD actC - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD CMS1_k127_981450_0 290397.Adeh_3184 6.254e-152 486.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria,2YV3K@29|Myxococcales 28221|Deltaproteobacteria G Glycosyl hydrolase 36 superfamily, catalytic domain - - 2.4.1.20 ko:K00702,ko:K13688 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000,ko01003 - GH94,GT36,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase CMS1_k127_981450_3 1463895.JODA01000051_gene6519 1.656e-10 72.0 COG2207@1|root,COG2207@2|Bacteria,2GK7C@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - HTH_18 CMS1_k127_981450_1 864069.MicloDRAFT_00051360 8.057e-24 103.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,1JVFR@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 CMS1_k127_981450_4 195250.CM001776_gene1220 1.176e-06 62.0 COG2304@1|root,COG3209@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,1GJ0D@1117|Cyanobacteria,1H29D@1129|Synechococcus 1117|Cyanobacteria M RHS Repeat - - - - - - - - - - - - He_PIG,RHS_repeat,SdrD_B CMS1_k127_981450_2 326427.Cagg_0409 2.887e-22 113.0 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - Arylsulfotran_2,Arylsulfotrans CMS1_k127_981889_0 429009.Adeg_1398 3.76e-232 738.0 COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,42EPX@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C CMS1_k127_981889_1 743525.TSC_c09830 5.438e-20 91.0 COG1963@1|root,COG1963@2|Bacteria,1WJV3@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Acid phosphatase vanadium-dependent haloperoxidase related - - - ko:K09775 - - - - ko00000 - - - DUF212 CMS1_k127_985794_3 234267.Acid_3225 2.621e-13 74.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_8,Trans_reg_C CMS1_k127_985794_0 1122611.KB903963_gene4803 2.691e-46 175.0 COG0640@1|root,COG0640@2|Bacteria,2GJT9@201174|Actinobacteria,4EI7R@85012|Streptosporangiales 201174|Actinobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_20 CMS1_k127_985794_1 40571.JOEA01000002_gene4947 7.24e-37 151.0 COG3832@1|root,COG3832@2|Bacteria,2GNVY@201174|Actinobacteria,4E2JC@85010|Pseudonocardiales 201174|Actinobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 CMS1_k127_985794_2 502025.Hoch_2249 2.461e-15 76.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,2YWXC@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N CMS1_k127_995281_0 1121468.AUBR01000033_gene1205 7.826e-191 604.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,42EYV@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO ## 2709 queries scanned ## Total time (seconds): 54.65508675575256 ## Rate: 49.57 q/s