## Thu Nov  7 07:15:57 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS1_bin.138.fa -m mmseqs --itype genome -o CMS1_bin.138 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS1_bin.138 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CMS1_k127_1077251_0	158190.SpiGrapes_0346	1.682e-264	820.0	COG1269@1|root,COG1269@2|Bacteria,2J594@203691|Spirochaetes	203691|Spirochaetes	C	V-type ATP synthase, subunit I	atpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
CMS1_k127_1077251_2	158190.SpiGrapes_0347	1.65e-82	275.0	COG0636@1|root,COG0636@2|Bacteria,2J7GW@203691|Spirochaetes	203691|Spirochaetes	C	ATP synthase subunit K	atpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
CMS1_k127_1077251_3	158190.SpiGrapes_0348	3.303e-69	238.0	COG0350@1|root,COG0350@2|Bacteria,2J8CJ@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
CMS1_k127_1077251_1	158190.SpiGrapes_0349	2.978e-96	319.0	COG3560@1|root,COG3560@2|Bacteria,2JAG9@203691|Spirochaetes	203691|Spirochaetes	S	Nitroreductase family	-	-	-	ko:K07078	-	-	-	-	ko00000	-	-	-	Nitroreductase
CMS1_k127_1077251_4	158190.SpiGrapes_0350	6.961e-32	127.0	COG2731@1|root,COG2731@2|Bacteria	2|Bacteria	G	single-species biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF386
CMS1_k127_1152774_0	158190.SpiGrapes_0420	0.0	1572.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,2J5MW@203691|Spirochaetes	203691|Spirochaetes	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
CMS1_k127_1152774_1	158190.SpiGrapes_0419	2.753e-235	741.0	COG0728@1|root,COG0728@2|Bacteria,2J697@203691|Spirochaetes	203691|Spirochaetes	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
CMS1_k127_1152774_2	546269.HMPREF0389_01483	4.356e-53	192.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,25QE3@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CMS1_k127_116965_1	478749.BRYFOR_09634	3.33e-125	409.0	COG0534@1|root,COG0534@2|Bacteria,1TPPJ@1239|Firmicutes,25AZE@186801|Clostridia	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_116965_2	158190.SpiGrapes_0292	4.889e-121	393.0	COG0500@1|root,COG2226@2|Bacteria,2J6ZJ@203691|Spirochaetes	203691|Spirochaetes	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS1_k127_116965_4	158190.SpiGrapes_0290	5.663e-52	188.0	COG0716@1|root,COG0716@2|Bacteria,2J7AQ@203691|Spirochaetes	203691|Spirochaetes	C	flavodoxin	fld	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
CMS1_k127_116965_0	158190.SpiGrapes_0288	2.056e-181	575.0	COG0534@1|root,COG0534@2|Bacteria,2J5V9@203691|Spirochaetes	203691|Spirochaetes	V	efflux protein, MATE family	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_1180478_11	158190.SpiGrapes_0521	7.307e-45	164.0	2ENIR@1|root,33G66@2|Bacteria,2JARW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1180478_6	158190.SpiGrapes_0522	4.058e-134	434.0	COG0003@1|root,COG0003@2|Bacteria,2JA2D@203691|Spirochaetes	203691|Spirochaetes	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
CMS1_k127_1180478_4	158190.SpiGrapes_0523	1.894e-195	615.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
CMS1_k127_1180478_2	158190.SpiGrapes_0524	4.096e-227	707.0	COG2309@1|root,COG2309@2|Bacteria,2J7AX@203691|Spirochaetes	203691|Spirochaetes	E	Aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
CMS1_k127_1180478_5	158190.SpiGrapes_0525	1.327e-136	437.0	COG1521@1|root,COG1521@2|Bacteria,2J698@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
CMS1_k127_1180478_1	158190.SpiGrapes_0526	0.0	1033.0	COG0488@1|root,COG0488@2|Bacteria,2J5P1@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
CMS1_k127_1180478_7	158190.SpiGrapes_0529	3.834e-99	325.0	COG0503@1|root,COG0503@2|Bacteria,2J7CM@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
CMS1_k127_1180478_3	158190.SpiGrapes_0530	3.994e-210	654.0	COG0533@1|root,COG0533@2|Bacteria,2J5WG@203691|Spirochaetes	203691|Spirochaetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS1_k127_1180478_14	243275.TDE_1610	7.359e-24	104.0	COG3093@1|root,COG3093@2|Bacteria,2J86U@203691|Spirochaetes	203691|Spirochaetes	K	addiction module antidote protein, HigA family	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
CMS1_k127_1180478_13	1370125.AUWT01000066_gene3706	7.976e-28	116.0	COG3549@1|root,COG3549@2|Bacteria,2IT6K@201174|Actinobacteria,23BGB@1762|Mycobacteriaceae	201174|Actinobacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
CMS1_k127_1180478_10	1123274.KB899423_gene1581	6.22e-47	172.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
CMS1_k127_1180478_9	1294142.CINTURNW_2567	5.47e-51	185.0	COG0454@1|root,COG0454@2|Bacteria,1VCQU@1239|Firmicutes,25FSA@186801|Clostridia,36JQ2@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
CMS1_k127_1180478_8	572479.Hprae_1048	8.183e-69	242.0	COG0491@1|root,COG0491@2|Bacteria,1V0KE@1239|Firmicutes,24D1B@186801|Clostridia	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_1180478_0	158190.SpiGrapes_0543	0.0	1530.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J5JP@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS1_k127_1223125_8	861450.HMPREF0080_01362	0.0004566	43.0	2E84J@1|root,332I9@2|Bacteria,1UQU8@1239|Firmicutes,4H8R3@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1223125_6	592028.GCWU000321_00562	2.04e-10	63.0	2DGDE@1|root,2ZVI3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1223125_1	158190.SpiGrapes_2645	1.28e-202	635.0	COG1638@1|root,COG1638@2|Bacteria,2J7YC@203691|Spirochaetes	203691|Spirochaetes	G	extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
CMS1_k127_1223125_3	158190.SpiGrapes_2646	1.177e-99	326.0	COG3090@1|root,COG3090@2|Bacteria,2JA7M@203691|Spirochaetes	203691|Spirochaetes	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
CMS1_k127_1223125_0	158190.SpiGrapes_2647	1.616e-242	753.0	COG1593@1|root,COG1593@2|Bacteria,2J73D@203691|Spirochaetes	203691|Spirochaetes	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS1_k127_1223125_2	158190.SpiGrapes_2648	3.438e-171	542.0	COG0329@1|root,COG0329@2|Bacteria,2J7DD@203691|Spirochaetes	203691|Spirochaetes	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS1_k127_1223125_4	158190.SpiGrapes_2649	9.562e-56	196.0	COG3836@1|root,COG3836@2|Bacteria,2JAZS@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS1_k127_1235305_9	553973.CLOHYLEM_05780	8.721e-122	397.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,222AT@1506553|Lachnoclostridium	186801|Clostridia	G	ATPases associated with a variety of cellular activities	-	-	-	ko:K17215	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_1235305_10	1195236.CTER_4671	1.226e-121	400.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,3WN1W@541000|Ruminococcaceae	186801|Clostridia	G	ribose xylose arabinose galactoside	rbsC	-	-	ko:K17214	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_1235305_7	1291050.JAGE01000001_gene375	2.467e-126	412.0	COG1879@1|root,COG1879@2|Bacteria,1UD25@1239|Firmicutes,24B8A@186801|Clostridia,3WNI2@541000|Ruminococcaceae	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K17213	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
CMS1_k127_1235305_4	545694.TREPR_0134	1.961e-174	551.0	COG1063@1|root,COG1063@2|Bacteria,2J6GV@203691|Spirochaetes	203691|Spirochaetes	C	Zinc-binding dehydrogenase	-	-	1.1.1.14,1.1.1.9	ko:K00008,ko:K05351	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_1235305_12	1499967.BAYZ01000109_gene2967	9.281e-92	308.0	COG1028@1|root,COG1028@2|Bacteria,2NPDM@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS1_k127_1235305_3	1125725.HMPREF1325_2179	6.258e-176	564.0	COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_1235305_14	1125725.HMPREF1325_2183	1.739e-33	136.0	COG0794@1|root,COG0794@2|Bacteria,2J8VZ@203691|Spirochaetes	203691|Spirochaetes	G	SIS domain	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
CMS1_k127_1235305_11	158190.SpiGrapes_1470	1.018e-111	366.0	COG3393@1|root,COG3393@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) family	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_9,FR47
CMS1_k127_1235305_6	158190.SpiGrapes_1469	1.804e-128	417.0	COG4295@1|root,COG4295@2|Bacteria,2J85S@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized protein conserved in bacteria (DUF2263)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2263
CMS1_k127_1235305_8	158190.SpiGrapes_1466	4.068e-122	394.0	COG2186@1|root,COG2186@2|Bacteria,2J8MR@203691|Spirochaetes	203691|Spirochaetes	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_1235305_1	158190.SpiGrapes_1465	9.11e-228	707.0	COG1638@1|root,COG1638@2|Bacteria,2J5GS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
CMS1_k127_1235305_13	158190.SpiGrapes_1464	4.856e-89	297.0	COG3090@1|root,COG3090@2|Bacteria,2JAKB@203691|Spirochaetes	203691|Spirochaetes	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
CMS1_k127_1235305_0	158190.SpiGrapes_1463	6.649e-240	745.0	COG1593@1|root,COG1593@2|Bacteria,2J7AP@203691|Spirochaetes	203691|Spirochaetes	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS1_k127_1235305_2	158190.SpiGrapes_1462	6.282e-197	616.0	COG1063@1|root,COG1063@2|Bacteria,2J5R7@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Alcohol dehydrogenase GroES-like	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_1235305_5	158190.SpiGrapes_1461	1.095e-134	431.0	COG1028@1|root,COG1028@2|Bacteria,2J7HY@203691|Spirochaetes	203691|Spirochaetes	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS1_k127_1245353_1	573413.Spirs_1222	4.336e-107	353.0	COG0395@1|root,COG0395@2|Bacteria,2J786@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1245353_0	573413.Spirs_1223	1.797e-191	605.0	COG1653@1|root,COG1653@2|Bacteria,2J66N@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
CMS1_k127_1245353_2	573413.Spirs_1224	1.959e-31	125.0	COG1472@1|root,COG1472@2|Bacteria,2J60D@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CMS1_k127_1248556_8	158190.SpiGrapes_0931	4.14e-192	604.0	COG1879@1|root,COG1879@2|Bacteria,2J95H@203691|Spirochaetes	203691|Spirochaetes	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
CMS1_k127_1248556_5	158190.SpiGrapes_0930	1.955e-261	812.0	COG1129@1|root,COG1129@2|Bacteria,2J6MQ@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS1_k127_1248556_11	158190.SpiGrapes_0929	2.096e-177	559.0	COG1172@1|root,COG1172@2|Bacteria,2J5S4@203691|Spirochaetes	203691|Spirochaetes	P	transport system permease	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS1_k127_1248556_10	158190.SpiGrapes_0928	1.681e-182	575.0	COG0673@1|root,COG0673@2|Bacteria,2J74N@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_1248556_9	158190.SpiGrapes_0927	4.365e-192	601.0	COG1082@1|root,COG1082@2|Bacteria,2J9B4@203691|Spirochaetes	203691|Spirochaetes	G	PFAM AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS1_k127_1248556_15	33035.JPJF01000032_gene2220	1.407e-131	461.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia,3Y288@572511|Blautia	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3
CMS1_k127_1248556_7	158190.SpiGrapes_0925	1.322e-202	634.0	COG0115@1|root,COG0115@2|Bacteria,2J6WR@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS1_k127_1248556_1	158190.SpiGrapes_0924	0.0	1046.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
CMS1_k127_1248556_6	158190.SpiGrapes_0923	1.657e-225	703.0	COG1509@1|root,COG1509@2|Bacteria	2|Bacteria	E	lysine 2,3-aminomutase activity	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
CMS1_k127_1248556_19	158189.SpiBuddy_2577	1.438e-117	389.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS1_k127_1248556_17	158190.SpiGrapes_0921	6.606e-124	406.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
CMS1_k127_1248556_20	158190.SpiGrapes_0920	2.294e-68	235.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
CMS1_k127_1248556_22	158190.SpiGrapes_0919	5.56e-54	193.0	COG0454@1|root,COG0456@2|Bacteria,2JB71@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_1248556_14	158190.SpiGrapes_0918	2.232e-133	432.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS1_k127_1248556_2	158190.SpiGrapes_0916	0.0	1009.0	COG0488@1|root,COG0488@2|Bacteria,2J5VJ@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG0488 ATPase components of ABC transporter with duplicated ATPase domains	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS1_k127_1248556_12	158190.SpiGrapes_0915	1.306e-138	450.0	COG0697@1|root,COG0697@2|Bacteria,2JAAC@203691|Spirochaetes	203691|Spirochaetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS1_k127_1248556_0	158190.SpiGrapes_0914	0.0	1620.0	COG0841@1|root,COG0841@2|Bacteria,2J5MZ@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS1_k127_1248556_16	158190.SpiGrapes_0913	9.304e-125	406.0	COG0845@1|root,COG0845@2|Bacteria,2J5BM@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
CMS1_k127_1248556_18	158190.SpiGrapes_0912	2.202e-122	405.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS1_k127_1248556_3	158190.SpiGrapes_0911	3.73e-321	986.0	COG2509@1|root,COG2509@2|Bacteria,2J658@203691|Spirochaetes	203691|Spirochaetes	S	PFAM FAD binding domain	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_binding_3,Pyr_redox_2
CMS1_k127_1248556_23	395494.Galf_1745	1.271e-35	144.0	COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,2VRAT@28216|Betaproteobacteria,44WHS@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Uracil DNA glycosylase superfamily	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS1_k127_1248556_13	158190.SpiGrapes_0902	2.916e-136	437.0	COG1319@1|root,COG1319@2|Bacteria,2J8UH@203691|Spirochaetes	203691|Spirochaetes	C	PFAM FAD binding domain in molybdopterin dehydrogenase	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS1_k127_1248556_21	1403313.AXBR01000018_gene3571	1.387e-54	198.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,4HINQ@91061|Bacilli,1ZGEA@1386|Bacillus	91061|Bacilli	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.17.1.4,1.2.5.3	ko:K00087,ko:K03518	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU32470	Fer2,Fer2_2
CMS1_k127_1248556_4	158190.SpiGrapes_0900	2.093e-308	948.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS1_k127_1256853_8	158190.SpiGrapes_1406	1.39e-127	413.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,2J7VZ@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial transcription activator, effector binding	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
CMS1_k127_1256853_5	158190.SpiGrapes_1407	6.272e-199	629.0	COG0402@1|root,COG0402@2|Bacteria	2|Bacteria	F	S-adenosylhomocysteine deaminase activity	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS1_k127_1256853_6	158190.SpiGrapes_1408	3.852e-180	567.0	COG5042@1|root,COG5042@2|Bacteria	2|Bacteria	F	nucleoside transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	NUP
CMS1_k127_1256853_2	158190.SpiGrapes_1409	2.867e-268	833.0	COG2070@1|root,COG2070@2|Bacteria,2JAST@203691|Spirochaetes	203691|Spirochaetes	C	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
CMS1_k127_1256853_10	158190.SpiGrapes_1410	1.071e-59	210.0	COG3576@1|root,COG3576@2|Bacteria,2JB5J@203691|Spirochaetes	203691|Spirochaetes	S	PFAM pyridoxamine 5'-phosphate	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
CMS1_k127_1256853_0	158190.SpiGrapes_1411	0.0	1045.0	COG1132@1|root,COG1132@2|Bacteria,2J5W8@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS1_k127_1256853_1	1120746.CCNL01000010_gene1145	1.767e-274	862.0	COG1132@1|root,COG1132@2|Bacteria,2NP2M@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS1_k127_1256853_9	158190.SpiGrapes_1413	5.708e-61	213.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34,MarR
CMS1_k127_1256853_3	158190.SpiGrapes_1414	8.909e-255	792.0	COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_1256853_4	158190.SpiGrapes_1415	1.218e-251	780.0	COG0402@1|root,COG0402@2|Bacteria	2|Bacteria	F	S-adenosylhomocysteine deaminase activity	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS1_k127_1256853_7	158190.SpiGrapes_1416	5.286e-152	482.0	COG1079@1|root,COG1079@2|Bacteria,2J6HU@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_1261805_7	158190.SpiGrapes_3060	2.271e-145	464.0	COG1609@1|root,COG1609@2|Bacteria,2J7E3@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_4
CMS1_k127_1261805_5	1123274.KB899406_gene1156	4.793e-173	548.0	COG1172@1|root,COG1172@2|Bacteria,2J78F@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_1261805_6	1123274.KB899406_gene1155	1.372e-156	501.0	COG1172@1|root,COG1172@2|Bacteria,2J781@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_1261805_1	760011.Spico_0336	1.237e-243	761.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10542	ko02010,map02010	M00214,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.3	-	-	ABC_tran
CMS1_k127_1261805_4	1123274.KB899406_gene1153	2.668e-179	565.0	COG1879@1|root,COG1879@2|Bacteria,2J6JD@203691|Spirochaetes	203691|Spirochaetes	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
CMS1_k127_1261805_10	158190.SpiGrapes_3057	8.239e-65	224.0	COG1051@1|root,COG1051@2|Bacteria,2J8CP@203691|Spirochaetes	203691|Spirochaetes	F	PFAM NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4
CMS1_k127_1261805_2	158190.SpiGrapes_3055	7.448e-201	642.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2J5T7@203691|Spirochaetes	203691|Spirochaetes	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
CMS1_k127_1261805_3	158190.SpiGrapes_3054	8.198e-199	623.0	COG4143@1|root,COG4143@2|Bacteria,2J6C7@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM ABC transporter, periplasmic binding protein, thiB subfamily	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
CMS1_k127_1261805_0	158190.SpiGrapes_3053	1.322e-290	899.0	COG1178@1|root,COG1178@2|Bacteria,2J5F7@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter (Permease)	-	-	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	BPD_transp_1
CMS1_k127_1261805_8	760011.Spico_0942	2.903e-119	393.0	COG3842@1|root,COG3842@2|Bacteria,2JA1Y@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02062	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	ABC_tran
CMS1_k127_1261805_12	158190.SpiGrapes_3050	1.884e-21	98.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,Peptidase_C13,Peptidase_C14
CMS1_k127_1279224_2	158189.SpiBuddy_2636	3.158e-52	185.0	COG1175@1|root,COG1175@2|Bacteria,2J9RF@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10193	ko02010,map02010	M00202	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.11	-	-	BPD_transp_1
CMS1_k127_1279224_1	760011.Spico_1208	7.868e-130	419.0	COG0395@1|root,COG0395@2|Bacteria,2J9SN@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10194	ko02010,map02010	M00202	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.11	-	-	BPD_transp_1
CMS1_k127_1279224_0	545695.TREAZ_0207	1.491e-151	487.0	COG1486@1|root,COG1486@2|Bacteria,2J730@203691|Spirochaetes	203691|Spirochaetes	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
CMS1_k127_1289802_4	158190.SpiGrapes_3002	2.62e-56	198.0	COG0793@1|root,COG0793@2|Bacteria,2JB6W@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1289802_1	158190.SpiGrapes_3001	1.204e-156	497.0	COG1647@1|root,COG1647@2|Bacteria,2J5E8@203691|Spirochaetes	203691|Spirochaetes	S	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
CMS1_k127_1289802_0	158190.SpiGrapes_3000	5.404e-157	498.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GerE
CMS1_k127_1289802_3	158190.SpiGrapes_2998	2.084e-82	274.0	COG1106@1|root,COG1106@2|Bacteria	2|Bacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K06926	-	-	-	-	ko00000	-	-	-	AAA_21
CMS1_k127_1376435_2	97139.C824_03770	2.289e-65	233.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,36DSG@31979|Clostridiaceae	186801|Clostridia	T	response regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
CMS1_k127_1376435_1	97139.C824_03769	5.76e-116	394.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,36FRE@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
CMS1_k127_1376435_0	97139.C824_03768	1.813e-206	649.0	COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia,36FUN@31979|Clostridiaceae	186801|Clostridia	G	Extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_1376435_3	1125699.HMPREF9194_00154	2.691e-57	205.0	COG1175@1|root,COG1175@2|Bacteria,2J82P@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1403105_1	1203606.HMPREF1526_00906	4.577e-38	149.0	COG1309@1|root,COG1309@2|Bacteria,1UYIP@1239|Firmicutes,249K5@186801|Clostridia,36F7M@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
CMS1_k127_1420599_6	158190.SpiGrapes_0642	3.847e-14	73.0	COG0424@1|root,COG0424@2|Bacteria,2J7EA@203691|Spirochaetes	203691|Spirochaetes	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CMS1_k127_1420599_0	158190.SpiGrapes_0643	5.912e-167	528.0	COG0052@1|root,COG0052@2|Bacteria,2J5GZ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
CMS1_k127_1420599_1	158190.SpiGrapes_0644	3.05e-153	487.0	COG0264@1|root,COG0264@2|Bacteria,2J58B@203691|Spirochaetes	203691|Spirochaetes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
CMS1_k127_1420599_5	158190.SpiGrapes_0645	5.707e-99	327.0	COG0233@1|root,COG0233@2|Bacteria,2J6PZ@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
CMS1_k127_1420599_3	158190.SpiGrapes_0646	4.974e-132	423.0	COG0020@1|root,COG0020@2|Bacteria,2J5Y6@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
CMS1_k127_1420599_4	158190.SpiGrapes_0647	1.347e-123	401.0	COG4589@1|root,COG4589@2|Bacteria,2J7JM@203691|Spirochaetes	203691|Spirochaetes	S	Phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CMS1_k127_1420599_2	158190.SpiGrapes_0648	5.786e-153	488.0	COG0743@1|root,COG0743@2|Bacteria,2J5M4@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
CMS1_k127_1432860_3	158190.SpiGrapes_2998	4.945e-159	503.0	COG1106@1|root,COG1106@2|Bacteria	2|Bacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K06926	-	-	-	-	ko00000	-	-	-	AAA_21
CMS1_k127_1432860_6	158190.SpiGrapes_2997	2.397e-98	324.0	COG4464@1|root,COG4464@2|Bacteria	2|Bacteria	GM	protein tyrosine phosphatase activity	cpsB	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS1_k127_1432860_5	158190.SpiGrapes_2996	9.753e-99	323.0	COG2109@1|root,COG2109@2|Bacteria,2J8WE@203691|Spirochaetes	203691|Spirochaetes	H	ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
CMS1_k127_1432860_4	158190.SpiGrapes_2995	4.074e-156	501.0	COG2063@1|root,COG2063@2|Bacteria,2J8Z2@203691|Spirochaetes	203691|Spirochaetes	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1432860_1	158190.SpiGrapes_2994	2.903e-167	531.0	COG1995@1|root,COG1995@2|Bacteria,2J6SI@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the PdxA family	-	-	1.1.1.408,1.1.1.409	ko:K22024	-	-	-	-	ko00000,ko01000	-	-	-	PdxA
CMS1_k127_1432860_0	158190.SpiGrapes_2992	8.436e-181	571.0	COG2984@1|root,COG2984@2|Bacteria,2J62D@203691|Spirochaetes	203691|Spirochaetes	S	PFAM ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
CMS1_k127_1432860_2	1105031.HMPREF1141_2722	1.854e-159	510.0	COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,36FD4@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS1_k127_1442825_2	158190.SpiGrapes_3039	6.05e-296	918.0	COG1092@1|root,COG1092@2|Bacteria,2JA8Z@203691|Spirochaetes	203691|Spirochaetes	H	PFAM S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
CMS1_k127_1442825_7	158190.SpiGrapes_3038	1.123e-72	247.0	28Y5G@1|root,2ZK0U@2|Bacteria,2JB1C@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1442825_3	158190.SpiGrapes_3037	1.197e-269	833.0	COG1109@1|root,COG1109@2|Bacteria,2J5GY@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS1_k127_1442825_4	158190.SpiGrapes_3036	2.969e-195	610.0	COG1087@1|root,COG1087@2|Bacteria,2J5YD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS1_k127_1442825_0	158190.SpiGrapes_3029	0.0	1573.0	COG0737@1|root,COG0737@2|Bacteria,2J5Z0@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos,PGA_cap
CMS1_k127_1442825_9	158190.SpiGrapes_3028	1.262e-28	115.0	2ERI0@1|root,33J3G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1442825_8	158190.SpiGrapes_3027	4.833e-46	168.0	COG0759@1|root,COG0759@2|Bacteria,2J8TC@203691|Spirochaetes	203691|Spirochaetes	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
CMS1_k127_1442825_6	158190.SpiGrapes_3026	1.389e-117	379.0	COG0572@1|root,COG0572@2|Bacteria,2J6XC@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine monophosphokinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
CMS1_k127_1442825_5	158190.SpiGrapes_3024	2.616e-194	608.0	COG2017@1|root,COG2017@2|Bacteria,2J5MM@203691|Spirochaetes	203691|Spirochaetes	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
CMS1_k127_1442825_1	158190.SpiGrapes_3023	0.0	1132.0	COG0481@1|root,COG0481@2|Bacteria,2J5V8@203691|Spirochaetes	203691|Spirochaetes	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
CMS1_k127_1450258_0	158190.SpiGrapes_1404	0.0	1511.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2J727@203691|Spirochaetes	203691|Spirochaetes	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
CMS1_k127_1450258_19	1278311.AUAL01000041_gene661	2.181e-07	55.0	COG1373@1|root,COG1373@2|Bacteria,3WSX6@544448|Tenericutes	544448|Tenericutes	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14
CMS1_k127_1450258_20	592026.GCWU0000282_000650	0.0002061	44.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,247ZX@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS1_k127_1450258_8	158190.SpiGrapes_1402	5.654e-183	580.0	COG1079@1|root,COG1079@2|Bacteria	2|Bacteria	S	Belongs to the binding-protein-dependent transport system permease family	rbsC-2	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_1450258_13	572544.Ilyop_0135	4.81e-111	369.0	COG4603@1|root,COG4603@2|Bacteria,37C49@32066|Fusobacteria	32066|Fusobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_1450258_3	158190.SpiGrapes_1400	4.528e-301	930.0	COG3845@1|root,COG3845@2|Bacteria	2|Bacteria	P	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_1450258_6	158190.SpiGrapes_1399	1.563e-203	635.0	COG1744@1|root,COG1744@2|Bacteria	2|Bacteria	ET	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
CMS1_k127_1450258_12	158190.SpiGrapes_1398	2.231e-152	486.0	COG1105@1|root,COG1105@2|Bacteria,2J7B3@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.144,2.7.1.56	ko:K00882,ko:K00917	ko00051,ko00052,ko01100,map00051,map00052,map01100	-	R02071,R03236	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS1_k127_1450258_15	158190.SpiGrapes_1397	2.364e-97	319.0	COG2131@1|root,COG2131@2|Bacteria,2J6UR@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
CMS1_k127_1450258_11	158190.SpiGrapes_1396	2.908e-162	516.0	COG1647@1|root,COG1647@2|Bacteria	2|Bacteria	M	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
CMS1_k127_1450258_5	158190.SpiGrapes_1395	1.673e-233	725.0	COG1883@1|root,COG1883@2|Bacteria,2J61F@203691|Spirochaetes	203691|Spirochaetes	C	Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
CMS1_k127_1450258_2	158190.SpiGrapes_1394	0.0	1132.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J5JF@203691|Spirochaetes	203691|Spirochaetes	C	Oxaloacetate decarboxylase, alpha subunit	oadA	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
CMS1_k127_1450258_17	158190.SpiGrapes_1393	1.3e-33	132.0	COG3630@1|root,COG3630@2|Bacteria	2|Bacteria	C	sodium ion export across plasma membrane	oadG	GO:0003674,GO:0003824,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008948,GO:0015672,GO:0016829,GO:0016830,GO:0016831,GO:0030001,GO:0051179,GO:0051234	4.1.1.3	ko:K01573	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_gamma
CMS1_k127_1450258_9	158190.SpiGrapes_1392	1.133e-182	573.0	COG0489@1|root,COG0489@2|Bacteria,2J573@203691|Spirochaetes	203691|Spirochaetes	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
CMS1_k127_1450258_14	158190.SpiGrapes_1391	4.679e-110	359.0	COG0494@1|root,COG0494@2|Bacteria,2J7P7@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS1_k127_1450258_16	158190.SpiGrapes_1390	1.334e-93	313.0	COG2968@1|root,COG2968@2|Bacteria,2J8B1@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
CMS1_k127_1450258_7	158190.SpiGrapes_1388	1.337e-195	612.0	COG0240@1|root,COG0240@2|Bacteria,2J68Z@203691|Spirochaetes	203691|Spirochaetes	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CMS1_k127_1450258_18	1268635.Loa_02043	1.999e-19	96.0	COG2153@1|root,COG2153@2|Bacteria,1PGJU@1224|Proteobacteria,1T75W@1236|Gammaproteobacteria,1JEXP@118969|Legionellales	118969|Legionellales	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
CMS1_k127_1450258_10	158190.SpiGrapes_1386	1.358e-176	561.0	COG1251@1|root,COG1251@2|Bacteria,2JAPS@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
CMS1_k127_1450258_1	158190.SpiGrapes_1385	0.0	1439.0	COG3345@1|root,COG3345@2|Bacteria,2J68S@203691|Spirochaetes	203691|Spirochaetes	G	alpha-galactosidase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
CMS1_k127_1450258_4	158190.SpiGrapes_1384	1.273e-236	736.0	2DU8W@1|root,33PE0@2|Bacteria,2JA2S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1494271_8	521045.Kole_0982	1.406e-26	120.0	COG1082@1|root,COG1082@2|Bacteria,2GDR2@200918|Thermotogae	200918|Thermotogae	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS1_k127_1494271_2	158190.SpiGrapes_3132	1.048e-194	616.0	COG3875@1|root,COG3875@2|Bacteria,2J6AY@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
CMS1_k127_1494271_1	158190.SpiGrapes_3133	2.522e-223	700.0	COG0126@1|root,COG0126@2|Bacteria,2J6Y0@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglycerate kinase	-	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
CMS1_k127_1494271_6	1123274.KB899411_gene3079	2.47e-164	522.0	COG0057@1|root,COG0057@2|Bacteria,2J6YR@203691|Spirochaetes	203691|Spirochaetes	C	glyceraldehyde-3-phosphate dehydrogenase, type II	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
CMS1_k127_1494271_5	158190.SpiGrapes_3135	1.827e-168	532.0	COG1082@1|root,COG1082@2|Bacteria,2J6VN@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS1_k127_1494271_0	158190.SpiGrapes_3136	0.0	1090.0	COG3962@1|root,COG3962@2|Bacteria,2J6S8@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the TPP enzyme family	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS1_k127_1494271_7	158190.SpiGrapes_3137	1.665e-153	487.0	COG3718@1|root,COG3718@2|Bacteria,2J83A@203691|Spirochaetes	203691|Spirochaetes	G	PFAM KduI IolB family	-	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
CMS1_k127_1494271_3	158190.SpiGrapes_3138	6.044e-179	566.0	COG0673@1|root,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_1494271_4	760011.Spico_0081	1.385e-175	556.0	COG1129@1|root,COG1129@2|Bacteria,2J79M@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1129 ABC-type sugar transport system ATPase component	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS1_k127_1502370_1	1298920.KI911353_gene147	4.635e-84	284.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,21YDF@1506553|Lachnoclostridium	186801|Clostridia	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
CMS1_k127_1502370_3	1449336.JQLO01000001_gene2207	4.742e-07	60.0	COG2188@1|root,COG2188@2|Bacteria,1TRF6@1239|Firmicutes,4HDCX@91061|Bacilli,27FZN@186828|Carnobacteriaceae	91061|Bacilli	K	UTRA	treR	-	-	ko:K03486	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
CMS1_k127_1502370_2	1298920.KI911353_gene145	1.652e-82	282.0	COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,25E2U@186801|Clostridia,21XFV@1506553|Lachnoclostridium	186801|Clostridia	F	Phosphorylase superfamily	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CMS1_k127_1502370_0	457421.CBFG_02739	3.8e-86	288.0	COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,25E2U@186801|Clostridia,268KI@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CMS1_k127_1505851_6	428125.CLOLEP_02811	1.224e-33	137.0	COG1621@1|root,COG1621@2|Bacteria,1TPAE@1239|Firmicutes,247UU@186801|Clostridia,3WGUV@541000|Ruminococcaceae	186801|Clostridia	G	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_32C,Glyco_hydro_32N
CMS1_k127_1505851_3	1408322.JHYK01000009_gene2196	1.892e-77	275.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,24AE3@186801|Clostridia,27P44@186928|unclassified Lachnospiraceae	186801|Clostridia	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
CMS1_k127_1505851_4	342113.DM82_6278	9.911e-65	241.0	COG0775@1|root,COG0775@2|Bacteria,1ND8Y@1224|Proteobacteria,2W5WW@28216|Betaproteobacteria,1KDWE@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
CMS1_k127_1505851_5	588581.Cpap_0356	1.166e-47	179.0	2CIFR@1|root,2Z835@2|Bacteria,1V97E@1239|Firmicutes,24KAE@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2589)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2589
CMS1_k127_1505851_7	755731.Clo1100_3675	2.095e-06	56.0	29JN6@1|root,306JH@2|Bacteria,1URYC@1239|Firmicutes,24Y2C@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2589)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2589
CMS1_k127_1505851_8	1124982.MSI_20710	0.0001952	50.0	2BRNB@1|root,32KMX@2|Bacteria,2J8V6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_1505851_0	697281.Mahau_0769	1.995e-86	295.0	COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,2492R@186801|Clostridia,42FXR@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_1505851_2	697281.Mahau_0771	7.934e-80	275.0	COG0395@1|root,COG0395@2|Bacteria,1TSAB@1239|Firmicutes,25C5T@186801|Clostridia,42JEU@68295|Thermoanaerobacterales	186801|Clostridia	P	COGs COG0395 ABC-type sugar transport system permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_1505851_1	1304880.JAGB01000001_gene913	2.968e-84	291.0	COG1397@1|root,COG1397@2|Bacteria,1VJGR@1239|Firmicutes,24SQ2@186801|Clostridia	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS1_k127_1505851_9	158189.SpiBuddy_0858	0.0002948	47.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_1512309_1	158190.SpiGrapes_3273	9.271e-84	289.0	COG2017@1|root,COG2017@2|Bacteria,2J7JE@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Aldose 1-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim
CMS1_k127_1512309_0	158190.SpiGrapes_3274	2.72e-120	388.0	COG0283@1|root,COG0283@2|Bacteria,2JBGI@203691|Spirochaetes	203691|Spirochaetes	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
CMS1_k127_1512309_2	158190.SpiGrapes_3275	4.899e-28	114.0	COG2731@1|root,COG2731@2|Bacteria	2|Bacteria	G	single-species biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1512474_3	158190.SpiGrapes_0402	4.005e-88	293.0	COG0125@1|root,COG0125@2|Bacteria,2J765@203691|Spirochaetes	203691|Spirochaetes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CMS1_k127_1512474_0	158190.SpiGrapes_0403	0.0	1792.0	COG2911@1|root,COG2911@2|Bacteria,2J5CF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Family of	-	-	-	-	-	-	-	-	-	-	-	-	TamB
CMS1_k127_1512474_2	158190.SpiGrapes_0404	0.0	1391.0	COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS1_k127_1512474_1	158190.SpiGrapes_0405	0.0	1442.0	COG0249@1|root,COG0249@2|Bacteria,2J5XM@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
CMS1_k127_1512474_4	158190.SpiGrapes_0406	1.919e-72	252.0	COG1040@1|root,COG1040@2|Bacteria	2|Bacteria	K	competence protein	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
CMS1_k127_1512474_5	158190.SpiGrapes_0407	9.485e-54	190.0	COG0779@1|root,COG0779@2|Bacteria,2J87E@203691|Spirochaetes	203691|Spirochaetes	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
CMS1_k127_1516257_2	869209.Tresu_0647	6.336e-23	105.0	COG3547@1|root,COG3547@2|Bacteria,2J7V0@203691|Spirochaetes	203691|Spirochaetes	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
CMS1_k127_1516257_6	575593.HMPREF0491_02458	1.84e-05	48.0	COG1943@1|root,COG1943@2|Bacteria,1V1CM@1239|Firmicutes,24BK2@186801|Clostridia,27MGX@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CMS1_k127_1516257_3	158190.SpiGrapes_2775	5.146e-19	86.0	COG2197@1|root,COG2197@2|Bacteria,2JBHD@203691|Spirochaetes	2|Bacteria	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,GerE,Mor,Response_reg,Y_Y_Y
CMS1_k127_1516257_0	158189.SpiBuddy_0763	1.565e-164	521.0	COG2207@1|root,COG2207@2|Bacteria,2JB9A@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1516257_1	158189.SpiBuddy_0762	5.22e-154	489.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_1517977_5	158190.SpiGrapes_0488	5.02e-185	582.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
CMS1_k127_1517977_8	158190.SpiGrapes_0486	1.464e-27	113.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	fmdB	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS1_k127_1517977_4	158190.SpiGrapes_0485	5.07e-201	627.0	COG0180@1|root,COG0180@2|Bacteria,2J68U@203691|Spirochaetes	203691|Spirochaetes	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
CMS1_k127_1517977_1	158190.SpiGrapes_0481	1.231e-304	937.0	COG1109@1|root,COG1109@2|Bacteria,2J7AT@203691|Spirochaetes	203691|Spirochaetes	G	alpha beta alpha domain II	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II
CMS1_k127_1517977_6	742740.HMPREF9474_00276	6.631e-137	439.0	COG2267@1|root,COG2267@2|Bacteria,1UZ5S@1239|Firmicutes,25CEG@186801|Clostridia,21XI8@1506553|Lachnoclostridium	186801|Clostridia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS1_k127_1517977_2	158190.SpiGrapes_0480	3.699e-247	765.0	COG3581@1|root,COG3581@2|Bacteria,2JBF3@203691|Spirochaetes	203691|Spirochaetes	I	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
CMS1_k127_1517977_0	158190.SpiGrapes_0479	0.0	1742.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,2J5ZA@203691|Spirochaetes	203691|Spirochaetes	I	CoA-substrate-specific enzyme activase	yxcA	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
CMS1_k127_1517977_3	158190.SpiGrapes_0478	1.187e-236	734.0	COG0301@1|root,COG0301@2|Bacteria,2J64Z@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
CMS1_k127_15295_0	158190.SpiGrapes_0352	4.168e-260	803.0	COG0178@1|root,COG0178@2|Bacteria,2J5BN@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS1_k127_1530933_1	870187.Thini_3060	2.771e-103	349.0	COG1373@1|root,COG1373@2|Bacteria,1RAB0@1224|Proteobacteria,1SA91@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS1_k127_1530933_0	592026.GCWU0000282_001748	5.226e-194	612.0	COG1373@1|root,COG1373@2|Bacteria,1TPFF@1239|Firmicutes,24CP6@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS1_k127_1543552_5	158190.SpiGrapes_2014	3.644e-61	212.0	COG2006@1|root,COG2006@2|Bacteria,2J6UZ@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS1_k127_1543552_4	158190.SpiGrapes_2015	1.15e-126	409.0	COG1802@1|root,COG1802@2|Bacteria,2J8MW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_1543552_1	158190.SpiGrapes_2016	4.467e-186	586.0	COG3959@1|root,COG3959@2|Bacteria,2J9WA@203691|Spirochaetes	203691|Spirochaetes	G	1-deoxy-D-xylulose-5-phosphate synthase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS1_k127_1543552_2	158190.SpiGrapes_2017	4.641e-178	560.0	COG3958@1|root,COG3958@2|Bacteria,2JBH3@203691|Spirochaetes	203691|Spirochaetes	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS1_k127_1543552_0	158189.SpiBuddy_2968	3.829e-204	642.0	COG1454@1|root,COG1454@2|Bacteria,2J9RG@203691|Spirochaetes	203691|Spirochaetes	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS1_k127_1543552_3	158190.SpiGrapes_2018	1.708e-150	478.0	COG1082@1|root,COG1082@2|Bacteria,2J8EP@203691|Spirochaetes	203691|Spirochaetes	G	TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS1_k127_1546770_0	158190.SpiGrapes_3179	4.986e-286	882.0	COG0246@1|root,COG0246@2|Bacteria,2J5PW@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Mannitol dehydrogenase	-	-	1.1.1.58	ko:K00041	ko00040,ko01100,map00040,map01100	M00631	R02555	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
CMS1_k127_1593290_13	351627.Csac_1103	1.332e-09	65.0	COG2972@1|root,COG2972@2|Bacteria,1TR81@1239|Firmicutes,24CKZ@186801|Clostridia,42FVI@68295|Thermoanaerobacterales	186801|Clostridia	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
CMS1_k127_1593290_4	935948.KE386494_gene116	3.147e-141	460.0	COG1653@1|root,COG1653@2|Bacteria,1UZ01@1239|Firmicutes,25B5I@186801|Clostridia,42FPB@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_1593290_7	180332.JTGN01000010_gene4559	3.882e-111	367.0	COG1175@1|root,COG1175@2|Bacteria,1TQX5@1239|Firmicutes,24B1Z@186801|Clostridia	186801|Clostridia	P	abc transporter permease protein	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1593290_8	545695.TREAZ_2533	3.04e-108	357.0	COG0395@1|root,COG0395@2|Bacteria,2J833@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1593290_0	309799.DICTH_0289	2.118e-197	644.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
CMS1_k127_1593290_2	760011.Spico_1483	1.146e-159	514.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	3.2.1.8,3.5.1.104	ko:K01181,ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	CBM9_1,CBM_4_9,Glyco_hydro_10,PEGA,Polysacc_deac_1,SLH
CMS1_k127_1593290_9	760011.Spico_1488	6.701e-102	354.0	COG1109@1|root,COG1109@2|Bacteria	2|Bacteria	G	phosphoglucosamine mutase activity	glmM	GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1886,iLJ478.TM0184,iSB619.SA_RS11275,iSBO_1134.SBO_3206	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS1_k127_1593290_1	760011.Spico_1487	5.903e-189	598.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
CMS1_k127_1593290_6	760011.Spico_1486	3.145e-120	393.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10193,ko:K15771,ko:K17242	ko02010,map02010	M00196,M00198,M00202,M00207,M00491,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.11,3.A.1.1.16,3.A.1.1.2,3.A.1.1.28,3.A.1.1.3,3.A.1.1.39	-	-	BPD_transp_1
CMS1_k127_1593290_5	760011.Spico_1485	8.278e-125	404.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	lacG	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_1593290_3	760011.Spico_1484	1.451e-155	497.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS1_k127_1593290_10	584708.Apau_2130	8.758e-56	212.0	COG3681@1|root,COG3681@2|Bacteria,3TAKE@508458|Synergistetes	508458|Synergistetes	S	Serine dehydratase alpha chain	-	-	-	-	-	-	-	-	-	-	-	-	SDH_alpha
CMS1_k127_1593290_11	1168289.AJKI01000056_gene3018	9.256e-40	159.0	COG0697@1|root,COG0697@2|Bacteria,4NH9M@976|Bacteroidetes,2FPTW@200643|Bacteroidia,3XKP0@558415|Marinilabiliaceae	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS1_k127_1593290_12	760011.Spico_1482	5.247e-33	132.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
CMS1_k127_1605768_18	158189.SpiBuddy_2487	9.202e-05	45.0	2EK5T@1|root,33DW7@2|Bacteria,2JB1W@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1605768_7	158190.SpiGrapes_2396	8.623e-125	401.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	MA20_15070	-	-	ko:K22293	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_1605768_9	158190.SpiGrapes_2395	1.503e-110	360.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	mtnB	-	4.1.2.17,5.1.3.4	ko:K01628,ko:K03077	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R02262,R05850	RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
CMS1_k127_1605768_0	158190.SpiGrapes_2394	1.077e-256	793.0	COG5441@1|root,COG5441@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
CMS1_k127_1605768_4	158190.SpiGrapes_2393	3.624e-173	543.0	COG0491@1|root,COG0491@2|Bacteria,2J9HK@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_1605768_6	158190.SpiGrapes_2392	8.417e-139	441.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
CMS1_k127_1605768_1	158190.SpiGrapes_2391	1.657e-256	794.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS1_k127_1605768_12	158190.SpiGrapes_2390	2.422e-96	317.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689,ko:K21394	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
CMS1_k127_1605768_3	158190.SpiGrapes_2389	2.436e-233	723.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
CMS1_k127_1605768_17	645991.Sgly_0012	2.869e-14	74.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,247ZX@186801|Clostridia,2611C@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS1_k127_1605768_19	1211819.CALK01000033_gene1296	0.0004181	48.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,3VQ1Q@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
CMS1_k127_1605768_16	1507.HMPREF0262_00493	1.095e-27	114.0	COG3041@1|root,COG3041@2|Bacteria,1VENE@1239|Firmicutes,24MW1@186801|Clostridia,36MNQ@31979|Clostridiaceae	186801|Clostridia	S	Addiction module toxin, RelE StbE family	-	-	-	ko:K19157	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YafQ_toxin
CMS1_k127_1605768_15	158189.SpiBuddy_2329	3.637e-30	123.0	COG0582@1|root,COG0582@2|Bacteria,2J7RB@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
CMS1_k127_1605768_8	158190.SpiGrapes_2438	9.736e-117	379.0	28KWY@1|root,2ZAD1@2|Bacteria,2JA85@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1605768_13	689781.AUJX01000016_gene2360	8.154e-69	237.0	28J1N@1|root,2Z8YI@2|Bacteria,1V11D@1239|Firmicutes,24EC5@186801|Clostridia,2PS55@265975|Oribacterium	186801|Clostridia	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS1_k127_1605768_2	1232453.BAIF02000026_gene4263	4.108e-250	776.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,268H9@186813|unclassified Clostridiales	186801|Clostridia	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS1_k127_1605768_5	556261.HMPREF0240_00290	5.849e-139	462.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,36DDA@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
CMS1_k127_1605768_10	1232443.BAIA02000124_gene1197	4.89e-104	346.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,26848@186813|unclassified Clostridiales	186801|Clostridia	S	Branched-chain amino acid transport system / permease component	tsgC13	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_1605768_11	1232443.BAIA02000124_gene1196	2.544e-103	347.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,26831@186813|unclassified Clostridiales	186801|Clostridia	S	Branched-chain amino acid transport system / permease component	tsgB13	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_1605768_14	1232443.BAIA02000124_gene1195	4.52e-47	172.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,2686E@186813|unclassified Clostridiales	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_1607496_1	158190.SpiGrapes_0496	7.535e-110	356.0	COG0336@1|root,COG0336@2|Bacteria,2J5KR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CMS1_k127_1607496_2	158190.SpiGrapes_0497	3.539e-86	287.0	COG0806@1|root,COG0806@2|Bacteria,2J73Y@203691|Spirochaetes	203691|Spirochaetes	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
CMS1_k127_1607496_5	158190.SpiGrapes_0498	1.433e-36	141.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
CMS1_k127_1607496_4	158190.SpiGrapes_0499	1.684e-46	168.0	COG0228@1|root,COG0228@2|Bacteria,2J8AD@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
CMS1_k127_1607496_0	158190.SpiGrapes_0500	1.46e-262	811.0	COG0541@1|root,COG0541@2|Bacteria,2J5MF@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
CMS1_k127_1607496_3	158190.SpiGrapes_0501	1.529e-77	259.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
CMS1_k127_160994_19	1449050.JNLE01000005_gene4568	1.06e-38	152.0	COG1309@1|root,COG1309@2|Bacteria,1TYNZ@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator, TetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_160994_6	1414720.CBYM010000014_gene2714	1.173e-143	469.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,36DJD@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	effD	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_160994_24	158190.SpiGrapes_2034	8.17e-05	47.0	COG3958@1|root,COG3958@2|Bacteria,2J64Y@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS1_k127_160994_22	158190.SpiGrapes_2034	1.787e-27	115.0	COG3958@1|root,COG3958@2|Bacteria,2J64Y@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS1_k127_160994_23	158190.SpiGrapes_2034	2.177e-12	68.0	COG3958@1|root,COG3958@2|Bacteria,2J64Y@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS1_k127_160994_21	760011.Spico_0122	6.938e-28	115.0	COG3958@1|root,COG3958@2|Bacteria,2J64Y@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS1_k127_160994_20	204536.SULAZ_1481	3.97e-34	138.0	COG0698@1|root,COG0698@2|Bacteria,2G43P@200783|Aquificae	200783|Aquificae	G	ribose 5-phosphate isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
CMS1_k127_160994_14	556261.HMPREF0240_00117	1.303e-84	286.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,36DCJ@31979|Clostridiaceae	186801|Clostridia	G	L-ribulose-5-phosphate 4-epimerase	araD	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
CMS1_k127_160994_17	1280673.AUJJ01000024_gene273	5.92e-77	270.0	COG3934@1|root,COG3934@2|Bacteria,1UUSA@1239|Firmicutes,258QH@186801|Clostridia,4BYEH@830|Butyrivibrio	186801|Clostridia	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
CMS1_k127_160994_0	1120746.CCNL01000017_gene2739	7.543e-271	838.0	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
CMS1_k127_160994_9	742738.HMPREF9460_03284	7.924e-114	372.0	COG0149@1|root,COG0149@2|Bacteria,1UY0I@1239|Firmicutes,248YC@186801|Clostridia,26B2P@186813|unclassified Clostridiales	186801|Clostridia	G	Triosephosphate isomerase	-	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
CMS1_k127_160994_16	1535287.JP74_00180	1.353e-80	279.0	COG0395@1|root,COG0395@2|Bacteria,1RC92@1224|Proteobacteria,2UQ5T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_160994_15	1535287.JP74_00185	5.24e-82	284.0	COG1175@1|root,COG1175@2|Bacteria,1RCGN@1224|Proteobacteria,2UP6R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_160994_18	1535287.JP74_00190	6.15e-61	228.0	COG1653@1|root,COG1653@2|Bacteria,1RKUG@1224|Proteobacteria,2US1T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
CMS1_k127_160994_12	537007.BLAHAN_06899	7.027e-89	304.0	COG1609@1|root,COG1609@2|Bacteria,1UK1H@1239|Firmicutes,249XN@186801|Clostridia,3XZFY@572511|Blautia	186801|Clostridia	K	Psort location Cytoplasmic, score 9.98	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_160994_7	158190.SpiGrapes_1297	8.003e-125	400.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,2J5A7@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth,PRA-CH,PRA-PH
CMS1_k127_160994_5	158190.SpiGrapes_1298	4.478e-155	491.0	COG0107@1|root,COG0107@2|Bacteria,2J6FB@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS1_k127_160994_13	1121094.KB894646_gene90	1.148e-87	296.0	COG0106@1|root,COG0106@2|Bacteria,4NEEX@976|Bacteroidetes,2FMBX@200643|Bacteroidia,4APC5@815|Bacteroidaceae	976|Bacteroidetes	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS1_k127_160994_11	158190.SpiGrapes_1300	1.454e-107	355.0	COG0118@1|root,COG0118@2|Bacteria,2J7EY@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS1_k127_160994_1	158190.SpiGrapes_1301	5.292e-227	706.0	COG0131@1|root,COG0241@1|root,COG0131@2|Bacteria,COG0241@2|Bacteria,2J6ZQ@203691|Spirochaetes	203691|Spirochaetes	E	imidazoleglycerol-phosphate dehydratase	hisB	-	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	Hydrolase_like,IGPD
CMS1_k127_160994_4	158189.SpiBuddy_0666	2.199e-158	507.0	COG0079@1|root,COG0079@2|Bacteria,2J6HN@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_160994_2	158190.SpiGrapes_1303	2.767e-212	666.0	COG0141@1|root,COG0141@2|Bacteria,2J5QF@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
CMS1_k127_160994_3	158190.SpiGrapes_1304	4.007e-170	537.0	COG0040@1|root,COG0040@2|Bacteria,2J8TS@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
CMS1_k127_160994_8	760011.Spico_1277	6.047e-122	399.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,2J83B@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS1_k127_160994_10	760011.Spico_1283	1.254e-108	355.0	COG4225@1|root,COG4225@2|Bacteria	2|Bacteria	S	unsaturated chondroitin disaccharide hydrolase activity	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
CMS1_k127_1628507_6	158190.SpiGrapes_0584	6.755e-141	450.0	COG1220@1|root,COG1220@2|Bacteria,2J68E@203691|Spirochaetes	203691|Spirochaetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
CMS1_k127_1628507_11	760011.Spico_0644	2.481e-74	254.0	COG5405@1|root,COG5405@2|Bacteria,2J608@203691|Spirochaetes	203691|Spirochaetes	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
CMS1_k127_1628507_5	158190.SpiGrapes_0586	3.612e-145	465.0	COG4974@1|root,COG4974@2|Bacteria,2J5UZ@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS1_k127_1628507_14	314724.BT0297	1.557e-15	87.0	COG0758@1|root,COG0758@2|Bacteria,2J6UM@203691|Spirochaetes	203691|Spirochaetes	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
CMS1_k127_1628507_7	158190.SpiGrapes_0588	2.434e-132	424.0	COG0730@1|root,COG0730@2|Bacteria,2J6DT@203691|Spirochaetes	203691|Spirochaetes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS1_k127_1628507_8	158190.SpiGrapes_0589	3.301e-123	398.0	COG4974@1|root,COG4974@2|Bacteria,2J7GT@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS1_k127_1628507_15	158190.SpiGrapes_0589	2.913e-10	61.0	COG4974@1|root,COG4974@2|Bacteria,2J7GT@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS1_k127_1628507_1	158190.SpiGrapes_0590	1.369e-234	730.0	COG0206@1|root,COG0206@2|Bacteria,2J5EQ@203691|Spirochaetes	203691|Spirochaetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
CMS1_k127_1628507_0	158190.SpiGrapes_0591	1.378e-249	774.0	COG0849@1|root,COG0849@2|Bacteria,2J5UK@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
CMS1_k127_1628507_3	158190.SpiGrapes_0593	1.58e-201	635.0	COG0772@1|root,COG0772@2|Bacteria,2J58T@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CMS1_k127_1628507_9	158190.SpiGrapes_0594	5.417e-115	379.0	COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes	203691|Spirochaetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
CMS1_k127_1628507_2	158190.SpiGrapes_0595	2.672e-228	714.0	COG0770@1|root,COG0770@2|Bacteria,2J5GH@203691|Spirochaetes	203691|Spirochaetes	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS1_k127_1628507_4	158190.SpiGrapes_0597	2.477e-174	548.0	COG0275@1|root,COG0275@2|Bacteria,2J6DH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
CMS1_k127_1628507_12	158190.SpiGrapes_0598	3.377e-70	238.0	COG2001@1|root,COG2001@2|Bacteria,2J7XS@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CMS1_k127_1655696_1	1123274.KB899420_gene4023	1.274e-45	173.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS1_k127_1655696_0	553973.CLOHYLEM_05037	1.95e-52	198.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,21XVX@1506553|Lachnoclostridium	186801|Clostridia	K	helix_turn _helix lactose operon repressor	ccpA	-	-	ko:K02529,ko:K03487	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_1655696_3	158189.SpiBuddy_0317	1.188e-17	83.0	2C08P@1|root,31YSD@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4417)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4417
CMS1_k127_1655696_2	714943.Mucpa_1740	2.258e-18	85.0	2E8MC@1|root,332YU@2|Bacteria,4NUZI@976|Bacteroidetes,1IZNV@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1659377_0	1123274.KB899408_gene3953	3.285e-194	614.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_1659377_3	1123274.KB899408_gene3954	2.561e-110	364.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K10118,ko:K15771	ko02010,map02010	M00196,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2,3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1659377_6	1123274.KB899408_gene3955	5.991e-97	325.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1659377_1	545695.TREAZ_1571	2.063e-181	581.0	COG1397@1|root,COG1397@2|Bacteria,2J725@203691|Spirochaetes	203691|Spirochaetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS1_k127_1659377_5	33035.JPJF01000011_gene1298	2.657e-101	341.0	COG0524@1|root,COG0524@2|Bacteria,1V9HT@1239|Firmicutes,24M6M@186801|Clostridia	186801|Clostridia	G	COG COG0524 Sugar kinases, ribokinase family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS1_k127_1659377_8	33035.JPJF01000011_gene1297	6.166e-71	252.0	COG1397@1|root,COG1397@2|Bacteria,1U2AQ@1239|Firmicutes,25MBA@186801|Clostridia,3Y1SA@572511|Blautia	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS1_k127_1659377_2	1125701.HMPREF1221_01787	2.73e-129	419.0	COG2084@1|root,COG2084@2|Bacteria,2J6NZ@203691|Spirochaetes	203691|Spirochaetes	C	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS1_k127_1659377_7	1293054.HSACCH_01936	2.994e-83	287.0	COG0111@1|root,COG0111@2|Bacteria,1TSDK@1239|Firmicutes,247Q4@186801|Clostridia,3WBQK@53433|Halanaerobiales	186801|Clostridia	C	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS1_k127_1659377_4	44251.PDUR_16355	4.367e-104	345.0	COG0395@1|root,COG0395@2|Bacteria,1UCH2@1239|Firmicutes,4HECV@91061|Bacilli,26UFW@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	msmG	-	-	ko:K02026,ko:K10122	-	M00197,M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1,3.A.1.1.20	-	-	BPD_transp_1
CMS1_k127_1681287_1	158190.SpiGrapes_0640	3.602e-37	140.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
CMS1_k127_1683851_1	158190.SpiGrapes_0839	2.464e-91	308.0	COG1030@1|root,COG1030@2|Bacteria,2JAME@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1683851_0	158190.SpiGrapes_0838	7.753e-149	482.0	COG4294@1|root,COG4294@2|Bacteria	2|Bacteria	L	response to UV	uvsE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	DUF1722,UvdE
CMS1_k127_1683851_2	158190.SpiGrapes_0837	6.429e-76	258.0	COG0386@1|root,COG0386@2|Bacteria,2J843@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
CMS1_k127_1683851_3	871968.DESME_08515	6.699e-54	195.0	COG1670@1|root,COG1670@2|Bacteria,1V1ZC@1239|Firmicutes,249K2@186801|Clostridia,2661N@186807|Peptococcaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
CMS1_k127_1683851_4	158190.SpiGrapes_0835	3.94e-12	66.0	COG1180@1|root,COG1180@2|Bacteria,2J5BK@203691|Spirochaetes	203691|Spirochaetes	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_1698825_3	158190.SpiGrapes_0441	1.126e-123	398.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2J5YW@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
CMS1_k127_1698825_5	267747.PPA0652	3.643e-13	71.0	2DTR4@1|root,33MCB@2|Bacteria,2HAJT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1698825_2	158190.SpiGrapes_0444	7.388e-146	465.0	COG1579@1|root,COG1579@2|Bacteria,2J6JN@203691|Spirochaetes	203691|Spirochaetes	S	Zn-ribbon protein, possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
CMS1_k127_1698825_0	760011.Spico_0618	1.379e-196	633.0	COG0568@1|root,COG0568@2|Bacteria,2J59P@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS1_k127_1698825_1	158190.SpiGrapes_0446	1.517e-187	589.0	COG0358@1|root,COG0358@2|Bacteria,2J5MX@203691|Spirochaetes	203691|Spirochaetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
CMS1_k127_1702517_5	573413.Spirs_1221	1.326e-118	388.0	COG1175@1|root,COG1175@2|Bacteria,2J7SD@203691|Spirochaetes	203691|Spirochaetes	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1702517_3	158190.SpiGrapes_2058	9.238e-135	432.0	COG0327@1|root,COG0327@2|Bacteria,2J6QQ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM dinuclear metal center protein, YbgI SA1388 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
CMS1_k127_1702517_0	158190.SpiGrapes_2057	0.0	1146.0	COG1067@1|root,COG1067@2|Bacteria,2J6SU@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
CMS1_k127_1702517_1	158189.SpiBuddy_2929	2.35e-192	612.0	COG0534@1|root,COG0534@2|Bacteria,2J60B@203691|Spirochaetes	203691|Spirochaetes	V	efflux protein, MATE family	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_1702517_4	158190.SpiGrapes_2055	1.443e-126	409.0	COG0566@1|root,COG0566@2|Bacteria,2J6AD@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
CMS1_k127_1702517_8	573413.Spirs_0315	2.286e-76	262.0	COG0313@1|root,COG0313@2|Bacteria,2J5DW@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
CMS1_k127_1702517_7	158190.SpiGrapes_2047	2.592e-99	330.0	COG1842@1|root,COG1842@2|Bacteria	2|Bacteria	KT	Phage shock protein A	pspA	GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141	-	ko:K03969	-	-	-	-	ko00000	-	-	-	LRAT,PspA_IM30
CMS1_k127_1702517_12	158190.SpiGrapes_2046	2.383e-29	118.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	pspB	-	-	ko:K03970,ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	DUF4097,PspB,PspC
CMS1_k127_1702517_2	158190.SpiGrapes_2045	1.363e-179	566.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	pspF	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS1_k127_1702517_6	158190.SpiGrapes_2051	8.391e-107	356.0	COG1842@1|root,COG1842@2|Bacteria,2J5MH@203691|Spirochaetes	203691|Spirochaetes	KT	Phage shock protein A	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
CMS1_k127_1702517_9	158190.SpiGrapes_2042	1.394e-60	210.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	pspB	-	-	ko:K03970,ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	DUF4097,PspB,PspC
CMS1_k127_1702517_10	158190.SpiGrapes_2048	4.775e-42	163.0	COG3595@1|root,COG3595@2|Bacteria,2J9CF@203691|Spirochaetes	203691|Spirochaetes	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS1_k127_1718568_1	670487.Ocepr_0409	4.555e-31	135.0	COG1653@1|root,COG1653@2|Bacteria,1WJIN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
CMS1_k127_1718568_2	632292.Calhy_2423	3.905e-23	106.0	COG1661@1|root,COG1661@2|Bacteria,1VJDC@1239|Firmicutes,25DY9@186801|Clostridia,42H9K@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
CMS1_k127_1718568_0	1410650.JHWL01000019_gene244	1.681e-111	365.0	COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,4BW9U@830|Butyrivibrio	186801|Clostridia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K01176,ko:K05343	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_1719401_4	158190.SpiGrapes_1045	7.592e-120	390.0	COG1011@1|root,COG1011@2|Bacteria,2JAI7@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_1719401_3	158190.SpiGrapes_1046	2.461e-163	516.0	COG0395@1|root,COG0395@2|Bacteria,2J64K@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_1719401_2	158190.SpiGrapes_1047	2.465e-190	598.0	COG1175@1|root,COG1175@2|Bacteria,2J5TH@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_1719401_0	158190.SpiGrapes_1048	5.316e-279	858.0	COG1653@1|root,COG1653@2|Bacteria,2J5W6@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_1719401_5	158190.SpiGrapes_1049	8.651e-67	228.0	COG1321@1|root,COG1321@2|Bacteria,2J87K@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Iron dependent repressor, metal binding and dimerisation domain	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
CMS1_k127_1719401_6	158190.SpiGrapes_1050	1.755e-36	138.0	COG1918@1|root,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
CMS1_k127_1719401_1	158190.SpiGrapes_1051	6.694e-241	748.0	COG0370@1|root,COG0370@2|Bacteria,2J5ZF@203691|Spirochaetes	203691|Spirochaetes	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
CMS1_k127_172623_17	702450.CUW_1633	3.39e-41	164.0	COG3677@1|root,COG3677@2|Bacteria,1UYY4@1239|Firmicutes	1239|Firmicutes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1,Zn_Tnp_IS1595
CMS1_k127_172623_7	158190.SpiGrapes_0812	1.798e-137	443.0	COG3965@1|root,COG3965@2|Bacteria,2JAAP@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Cation efflux	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
CMS1_k127_172623_16	158190.SpiGrapes_0813	1.147e-54	195.0	COG4892@1|root,COG4892@2|Bacteria	2|Bacteria	S	Cytochrome b5-like Heme/Steroid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
CMS1_k127_172623_11	158190.SpiGrapes_0814	1.146e-114	375.0	COG0600@1|root,COG0600@2|Bacteria,2J80T@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
CMS1_k127_172623_10	158190.SpiGrapes_0815	4.928e-116	378.0	COG1116@1|root,COG1116@2|Bacteria,2J89T@203691|Spirochaetes	203691|Spirochaetes	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
CMS1_k127_172623_8	158190.SpiGrapes_0816	9.499e-128	415.0	COG0715@1|root,COG0715@2|Bacteria,2J7TW@203691|Spirochaetes	203691|Spirochaetes	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
CMS1_k127_172623_12	158190.SpiGrapes_0817	1.01e-82	279.0	COG0163@1|root,COG0163@2|Bacteria,2J8AT@203691|Spirochaetes	203691|Spirochaetes	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
CMS1_k127_172623_6	158190.SpiGrapes_0818	3.041e-141	452.0	COG0382@1|root,COG0382@2|Bacteria,2J7QJ@203691|Spirochaetes	203691|Spirochaetes	H	4-hydroxybenzoate polyprenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
CMS1_k127_172623_1	158190.SpiGrapes_0819	1.039e-287	886.0	COG0043@1|root,COG0043@2|Bacteria,2J6K1@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
CMS1_k127_172623_2	158190.SpiGrapes_0820	1.75e-211	663.0	COG4939@1|root,COG4939@2|Bacteria,2J7W0@203691|Spirochaetes	203691|Spirochaetes	S	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_172623_0	158190.SpiGrapes_0821	0.0	1135.0	COG1252@1|root,COG1252@2|Bacteria,2J79T@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS1_k127_172623_5	158190.SpiGrapes_0822	4.303e-151	484.0	COG0142@1|root,COG0142@2|Bacteria,2J7G9@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS1_k127_172623_14	158190.SpiGrapes_0826	1.205e-79	267.0	COG0517@1|root,COG0517@2|Bacteria,2JBGA@203691|Spirochaetes	203691|Spirochaetes	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
CMS1_k127_172623_4	158190.SpiGrapes_0827	7.208e-169	537.0	COG0798@1|root,COG0798@2|Bacteria,2J5T6@203691|Spirochaetes	203691|Spirochaetes	P	Bile acid	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
CMS1_k127_172623_19	158190.SpiGrapes_0828	8.422e-36	142.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
CMS1_k127_172623_15	158190.SpiGrapes_0830	1.888e-66	231.0	COG0701@1|root,COG0701@2|Bacteria,2JAMN@203691|Spirochaetes	203691|Spirochaetes	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
CMS1_k127_172623_13	158190.SpiGrapes_0831	3.315e-81	278.0	COG0701@1|root,COG0701@2|Bacteria,2JAEM@203691|Spirochaetes	203691|Spirochaetes	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
CMS1_k127_172623_9	158190.SpiGrapes_0833	1.89e-117	384.0	COG0664@1|root,COG0664@2|Bacteria,2J7Y7@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator, Crp	-	-	-	ko:K01420,ko:K21562	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_172623_3	158190.SpiGrapes_0834	1.232e-174	550.0	COG1882@1|root,COG1882@2|Bacteria,2J62Y@203691|Spirochaetes	203691|Spirochaetes	C	formate acetyltransferase	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
CMS1_k127_1729463_5	158190.SpiGrapes_0675	3.619e-73	248.0	COG0372@1|root,COG0372@2|Bacteria,2J571@203691|Spirochaetes	203691|Spirochaetes	C	citrate synthase	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS1_k127_1729463_6	158190.SpiGrapes_0673	1.748e-50	180.0	COG0640@1|root,COG0640@2|Bacteria,2J8I1@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
CMS1_k127_1729463_1	158190.SpiGrapes_0672	7.251e-92	308.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.3.1.2	ko:K00207	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00978,R01415,R08226	RC00072,RC00123,RC02245	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7,Fer4_9
CMS1_k127_1729463_2	906968.Trebr_0427	8.897e-83	285.0	COG0395@1|root,COG0395@2|Bacteria,2J5WH@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1729463_4	158189.SpiBuddy_1771	6.261e-81	282.0	COG1175@1|root,COG1175@2|Bacteria,2J71Z@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1729463_0	906968.Trebr_0429	3.146e-124	412.0	COG1653@1|root,COG1653@2|Bacteria,2J5WB@203691|Spirochaetes	203691|Spirochaetes	G	bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
CMS1_k127_1729463_3	744872.Spica_0352	1.773e-82	287.0	COG1940@1|root,COG1940@2|Bacteria,2J7X4@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator sugar kinase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
CMS1_k127_173069_0	158190.SpiGrapes_1193	3.983e-295	909.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes	203691|Spirochaetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
CMS1_k127_173069_4	158190.SpiGrapes_1192	4.663e-80	273.0	COG0237@1|root,COG0237@2|Bacteria,2J810@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
CMS1_k127_173069_2	158190.SpiGrapes_1190	1.758e-199	624.0	COG1509@1|root,COG1509@2|Bacteria,2J6VS@203691|Spirochaetes	203691|Spirochaetes	C	TIGRFAM KamA family protein	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
CMS1_k127_173069_1	158190.SpiGrapes_1189	5.444e-237	737.0	COG2211@1|root,COG2211@2|Bacteria,2J5PU@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_1744255_2	158190.SpiGrapes_0316	3.926e-181	572.0	COG1609@1|root,COG1609@2|Bacteria,2J7R5@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
CMS1_k127_1744255_0	158190.SpiGrapes_0317	2.435e-294	912.0	COG0366@1|root,COG0366@2|Bacteria,2J6ZP@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_1744255_4	545695.TREAZ_2316	1.442e-121	396.0	COG0395@1|root,COG0395@2|Bacteria,2J786@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1744255_3	545695.TREAZ_2317	3.207e-126	410.0	COG1175@1|root,COG1175@2|Bacteria,2J5HQ@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1744255_1	545695.TREAZ_2318	6.688e-193	613.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
CMS1_k127_1768097_2	158189.SpiBuddy_2045	2.938e-125	406.0	COG0500@1|root,COG0500@2|Bacteria,2J902@203691|Spirochaetes	203691|Spirochaetes	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1768097_0	411471.SUBVAR_06764	9.674e-167	535.0	COG1653@1|root,COG1653@2|Bacteria,1TS2P@1239|Firmicutes,24EIW@186801|Clostridia,3WRST@541000|Ruminococcaceae	186801|Clostridia	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_1768097_3	1235792.C808_04539	3.353e-124	418.0	COG3940@1|root,COG3940@2|Bacteria,1V08J@1239|Firmicutes,24E3E@186801|Clostridia,27N51@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
CMS1_k127_1768097_4	457421.CBFG_01709	7.15e-102	338.0	COG0395@1|root,COG0395@2|Bacteria,1TQTW@1239|Firmicutes,2485X@186801|Clostridia	186801|Clostridia	P	Abc transporter, permease protein	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1768097_1	457421.CBFG_01710	1.09e-125	407.0	COG1175@1|root,COG1175@2|Bacteria,1UYN7@1239|Firmicutes,24CHC@186801|Clostridia	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_1768097_5	411471.SUBVAR_06760	1.266e-84	299.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V017@1239|Firmicutes,25KIR@186801|Clostridia,3WPMD@541000|Ruminococcaceae	186801|Clostridia	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
CMS1_k127_1768097_6	1499684.CCNP01000025_gene3589	1.958e-12	69.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,248RT@186801|Clostridia,36G92@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
CMS1_k127_1779204_4	760011.Spico_1482	6.676e-90	303.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
CMS1_k127_1779204_3	1007096.BAGW01000034_gene1363	5.296e-107	364.0	COG2508@1|root,COG2508@2|Bacteria,1W7B5@1239|Firmicutes,25N0D@186801|Clostridia,2N7VI@216572|Oscillospiraceae	186801|Clostridia	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
CMS1_k127_1779204_0	931626.Awo_c31580	0.0	1296.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,25VG3@186806|Eubacteriaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	ADC,Oxidored_FMN,Pyr_redox_2
CMS1_k127_1779204_2	158190.SpiGrapes_1725	6.071e-116	379.0	2FGT0@1|root,348NC@2|Bacteria,2J7M1@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1779204_1	655815.ZPR_4138	4.294e-132	434.0	COG3550@1|root,COG3550@2|Bacteria,4NFYY@976|Bacteroidetes,1HXAI@117743|Flavobacteriia	976|Bacteroidetes	S	Pfam:HipA_N	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
CMS1_k127_1779204_5	518637.EUBIFOR_01310	1.048e-30	124.0	COG1476@1|root,COG1476@2|Bacteria,1TUZ5@1239|Firmicutes,3VU56@526524|Erysipelotrichia	526524|Erysipelotrichia	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1784295_9	697281.Mahau_2617	1.655e-86	301.0	COG2972@1|root,COG2972@2|Bacteria,1TR81@1239|Firmicutes,24CKZ@186801|Clostridia,42FVI@68295|Thermoanaerobacterales	186801|Clostridia	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
CMS1_k127_1784295_8	180332.JTGN01000010_gene4562	3.659e-89	312.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UNEQ@1239|Firmicutes,24E34@186801|Clostridia	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
CMS1_k127_1784295_2	33035.JPJF01000083_gene5112	3.376e-184	587.0	COG0554@1|root,COG0554@2|Bacteria,1TRX3@1239|Firmicutes,24A76@186801|Clostridia,3XZRZ@572511|Blautia	186801|Clostridia	C	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
CMS1_k127_1784295_7	435590.BVU_0358	6.859e-103	343.0	COG3958@1|root,COG3958@2|Bacteria,4NEI8@976|Bacteroidetes,2FQ5P@200643|Bacteroidia,4AKNM@815|Bacteroidaceae	976|Bacteroidetes	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS1_k127_1784295_4	1122919.KB905570_gene3026	6.925e-111	365.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,4HD97@91061|Bacilli,26VE7@186822|Paenibacillaceae	91061|Bacilli	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS1_k127_1784295_0	1105031.HMPREF1141_0016	8.169e-270	835.0	COG2407@1|root,COG2407@2|Bacteria,1TQDX@1239|Firmicutes,247N8@186801|Clostridia,36F01@31979|Clostridiaceae	186801|Clostridia	G	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome
CMS1_k127_1784295_10	1123274.KB899411_gene3045	3.637e-75	261.0	COG1349@1|root,COG1349@2|Bacteria,2J8FK@203691|Spirochaetes	203691|Spirochaetes	K	DeoR C terminal sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
CMS1_k127_1784295_3	158190.SpiGrapes_1754	2.027e-159	505.0	COG4866@1|root,COG4866@2|Bacteria,2J5HZ@203691|Spirochaetes	203691|Spirochaetes	S	conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
CMS1_k127_1784295_5	158190.SpiGrapes_1755	7.029e-108	356.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	Acetyltransf_9,DUF2156,SCP2_2
CMS1_k127_1784295_11	158190.SpiGrapes_1757	2.987e-42	160.0	2DBX9@1|root,2ZBN9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1784295_6	272563.CD630_33220	7.503e-104	339.0	COG1657@1|root,COG1657@2|Bacteria,1TPY3@1239|Firmicutes,247MQ@186801|Clostridia	186801|Clostridia	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1786556_0	158190.SpiGrapes_0353	0.0	1154.0	COG1452@1|root,COG1452@2|Bacteria,2J5EC@203691|Spirochaetes	203691|Spirochaetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1809805_5	158190.SpiGrapes_0076	2.868e-34	132.0	COG2033@1|root,COG2033@2|Bacteria	2|Bacteria	C	superoxide reductase activity	dfx	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016721,GO:0019430,GO:0022900,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
CMS1_k127_1809805_2	158190.SpiGrapes_0077	4.404e-148	472.0	COG0226@1|root,COG0226@2|Bacteria,2J83M@203691|Spirochaetes	203691|Spirochaetes	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
CMS1_k127_1809805_4	760011.Spico_0436	5.576e-91	307.0	COG0573@1|root,COG0573@2|Bacteria,2J7ES@203691|Spirochaetes	203691|Spirochaetes	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS1_k127_1809805_0	158190.SpiGrapes_0079	7.491e-224	702.0	COG0581@1|root,COG0581@2|Bacteria,2J7DU@203691|Spirochaetes	203691|Spirochaetes	P	phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
CMS1_k127_1809805_1	158190.SpiGrapes_0080	1.509e-150	479.0	COG1117@1|root,COG1117@2|Bacteria,2J6DF@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
CMS1_k127_1809805_3	158190.SpiGrapes_0081	7.927e-124	398.0	COG0704@1|root,COG0704@2|Bacteria,2J8BS@203691|Spirochaetes	203691|Spirochaetes	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CMS1_k127_1809805_6	158189.SpiBuddy_1676	7.125e-20	91.0	COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes	203691|Spirochaetes	V	Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
CMS1_k127_1814844_3	158190.SpiGrapes_0856	9.551e-05	44.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH
CMS1_k127_1814844_2	158190.SpiGrapes_0857	5.239e-86	288.0	COG0500@1|root,COG0500@2|Bacteria,2JBGV@203691|Spirochaetes	203691|Spirochaetes	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1814844_1	158190.SpiGrapes_0858	1.317e-239	745.0	COG3579@1|root,COG3579@2|Bacteria,2J5YK@203691|Spirochaetes	203691|Spirochaetes	E	Peptidase C1-like family	-	-	3.4.22.40	ko:K01372	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C1_2
CMS1_k127_1814844_0	158190.SpiGrapes_0859	5.374e-283	874.0	COG0145@1|root,COG0145@2|Bacteria	2|Bacteria	EQ	ligase activity	apc3	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
CMS1_k127_1817488_19	158190.SpiGrapes_0346	1.89e-26	111.0	COG1269@1|root,COG1269@2|Bacteria,2J594@203691|Spirochaetes	203691|Spirochaetes	C	V-type ATP synthase, subunit I	atpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
CMS1_k127_1817488_9	158190.SpiGrapes_0345	2.565e-113	367.0	COG1394@1|root,COG1394@2|Bacteria,2J59S@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
CMS1_k127_1817488_3	158190.SpiGrapes_0344	2.571e-267	824.0	COG1156@1|root,COG1156@2|Bacteria,2J574@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS1_k127_1817488_1	158190.SpiGrapes_0343	0.0	1101.0	COG1155@1|root,COG1155@2|Bacteria,2J59J@203691|Spirochaetes	203691|Spirochaetes	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
CMS1_k127_1817488_15	158190.SpiGrapes_0342	5.783e-81	273.0	2DKVJ@1|root,30H9C@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2764)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2764
CMS1_k127_1817488_13	158190.SpiGrapes_0341	4.017e-94	312.0	COG1390@1|root,COG1390@2|Bacteria,2J7I5@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	DivIVA,vATP-synt_E
CMS1_k127_1817488_5	158190.SpiGrapes_0338	9.056e-150	476.0	COG2820@1|root,COG2820@2|Bacteria,2J5TI@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CMS1_k127_1817488_14	158190.SpiGrapes_0337	1.615e-85	284.0	28NIH@1|root,2ZBJX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1817488_7	1195236.CTER_2871	9.116e-123	408.0	COG4908@1|root,COG4908@2|Bacteria,1TS0H@1239|Firmicutes,24B0M@186801|Clostridia,3WSFR@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Condensation,DUF1298
CMS1_k127_1817488_0	158190.SpiGrapes_0335	0.0	1169.0	COG1193@1|root,COG1193@2|Bacteria,2J59D@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
CMS1_k127_1817488_11	760011.Spico_0454	2.394e-106	354.0	COG1162@1|root,COG1162@2|Bacteria,2J5AI@203691|Spirochaetes	203691|Spirochaetes	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
CMS1_k127_1817488_10	158190.SpiGrapes_0333	2.065e-109	355.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	ko:K18555	-	M00729	-	-	ko00000,ko00002,ko01504	-	-	-	Pentapeptide,Pentapeptide_4
CMS1_k127_1817488_8	158190.SpiGrapes_0332	1.415e-115	374.0	COG0491@1|root,COG0491@2|Bacteria,2J7B4@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_1817488_4	158190.SpiGrapes_0331	8.924e-151	481.0	COG0564@1|root,COG0564@2|Bacteria,2J63B@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil	rluD_1	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
CMS1_k127_1817488_17	158190.SpiGrapes_0330	2.672e-40	154.0	290S3@1|root,34CB1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1817488_12	158190.SpiGrapes_0329	4.277e-103	339.0	COG0325@1|root,COG0325@2|Bacteria,2J71S@203691|Spirochaetes	203691|Spirochaetes	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
CMS1_k127_1817488_6	158190.SpiGrapes_0328	8.976e-124	402.0	COG4905@1|root,COG4905@2|Bacteria,2J7SH@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG4905 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
CMS1_k127_1817488_2	158190.SpiGrapes_0326	2.728e-304	950.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,2JBH4@203691|Spirochaetes	203691|Spirochaetes	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,dCache_1
CMS1_k127_1821217_1	158190.SpiGrapes_2358	6.487e-182	574.0	COG1609@1|root,COG1609@2|Bacteria,2J6QG@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI
CMS1_k127_1821217_0	158189.SpiBuddy_0687	8.507e-226	712.0	COG1966@1|root,COG1966@2|Bacteria,2J6EJ@203691|Spirochaetes	203691|Spirochaetes	T	Carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
CMS1_k127_1821217_2	158190.SpiGrapes_1340	8.543e-38	143.0	COG0534@1|root,COG0534@2|Bacteria,2J6QF@203691|Spirochaetes	203691|Spirochaetes	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_183549_0	158190.SpiGrapes_0612	1.237e-162	517.0	COG0534@1|root,COG0534@2|Bacteria,2J6QF@203691|Spirochaetes	203691|Spirochaetes	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_183549_3	158190.SpiGrapes_0614	4.825e-14	76.0	COG0606@1|root,COG0606@2|Bacteria,2J59R@203691|Spirochaetes	203691|Spirochaetes	O	magnesium chelatase	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	Mg_chelatase
CMS1_k127_183549_4	158190.SpiGrapes_0614	2.127e-13	72.0	COG0606@1|root,COG0606@2|Bacteria,2J59R@203691|Spirochaetes	203691|Spirochaetes	O	magnesium chelatase	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	Mg_chelatase
CMS1_k127_183549_2	158190.SpiGrapes_3111	7.833e-158	504.0	COG1363@1|root,COG1363@2|Bacteria,2J70N@203691|Spirochaetes	203691|Spirochaetes	G	peptidase M42	frvX	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
CMS1_k127_183549_1	158190.SpiGrapes_0617	6.188e-161	511.0	COG1012@1|root,COG1012@2|Bacteria,2J5FJ@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the aldehyde dehydrogenase family	ywdH	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS1_k127_1847876_9	742766.HMPREF9455_02270	9.424e-115	379.0	COG0329@1|root,COG0329@2|Bacteria,4NH72@976|Bacteroidetes,2FWJE@200643|Bacteroidia,22ZZ8@171551|Porphyromonadaceae	976|Bacteroidetes	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
CMS1_k127_1847876_2	573413.Spirs_0202	8.716e-165	527.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
CMS1_k127_1847876_12	573413.Spirs_0203	9.547e-55	198.0	COG1309@1|root,COG1309@2|Bacteria,2JB0N@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_1847876_4	469617.FUAG_00796	1.227e-145	473.0	COG1473@1|root,COG1473@2|Bacteria,378AX@32066|Fusobacteria	32066|Fusobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer
CMS1_k127_1847876_7	158190.SpiGrapes_1068	4.959e-117	381.0	COG0561@1|root,COG0561@2|Bacteria,2J5FZ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
CMS1_k127_1847876_11	713586.KB900536_gene2842	1.434e-84	302.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1S0ED@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
CMS1_k127_1847876_3	158190.SpiGrapes_1059	5.355e-153	485.0	COG0657@1|root,COG0657@2|Bacteria,2J84A@203691|Spirochaetes	203691|Spirochaetes	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
CMS1_k127_1847876_1	158190.SpiGrapes_1058	3.332e-262	811.0	COG2509@1|root,COG2509@2|Bacteria,2J6ED@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Pyr_redox_2
CMS1_k127_1847876_10	158189.SpiBuddy_0935	1.035e-86	304.0	COG3177@1|root,COG3177@2|Bacteria,2JB2M@203691|Spirochaetes	203691|Spirochaetes	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1847876_0	158190.SpiGrapes_1056	3.136e-282	873.0	COG3653@1|root,COG3653@2|Bacteria,2J7BR@203691|Spirochaetes	203691|Spirochaetes	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
CMS1_k127_1847876_6	158190.SpiGrapes_1055	8.6e-138	441.0	COG1126@1|root,COG1126@2|Bacteria,2J5EK@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
CMS1_k127_1847876_8	158190.SpiGrapes_1054	1.025e-116	377.0	COG0765@1|root,COG0765@2|Bacteria,2J6Q7@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	hisM	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
CMS1_k127_1847876_5	158190.SpiGrapes_1053	9.504e-143	454.0	COG0834@1|root,COG0834@2|Bacteria,2J6U3@203691|Spirochaetes	203691|Spirochaetes	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS1_k127_1878817_16	158190.SpiGrapes_1439	9.246e-139	446.0	COG1737@1|root,COG1737@2|Bacteria,2J763@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix domain, rpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
CMS1_k127_1878817_4	158190.SpiGrapes_1440	8.846e-269	832.0	COG0362@1|root,COG0362@2|Bacteria,2J661@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
CMS1_k127_1878817_6	158190.SpiGrapes_1441	8.483e-207	650.0	COG0524@1|root,COG0524@2|Bacteria,2J70H@203691|Spirochaetes	203691|Spirochaetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
CMS1_k127_1878817_7	158190.SpiGrapes_1444	1.737e-189	594.0	COG1397@1|root,COG1397@2|Bacteria,2J7FF@203691|Spirochaetes	203691|Spirochaetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS1_k127_1878817_1	158190.SpiGrapes_1445	0.0	1177.0	COG1397@1|root,COG1397@2|Bacteria,2J725@203691|Spirochaetes	203691|Spirochaetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS1_k127_1878817_2	158190.SpiGrapes_1446	3.097e-290	897.0	COG1653@1|root,COG1653@2|Bacteria,2J6BB@203691|Spirochaetes	203691|Spirochaetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
CMS1_k127_1878817_13	158190.SpiGrapes_1447	1.443e-159	508.0	COG0395@1|root,COG0395@2|Bacteria,2J7U5@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
CMS1_k127_1878817_9	158190.SpiGrapes_1448	1.13e-174	551.0	COG4209@1|root,COG4209@2|Bacteria,2J740@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
CMS1_k127_1878817_19	158190.SpiGrapes_1449	3.242e-54	192.0	2CDKX@1|root,32RXZ@2|Bacteria,2J91F@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4387)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4387
CMS1_k127_1878817_3	158190.SpiGrapes_1450	2.353e-269	832.0	COG1574@1|root,COG1574@2|Bacteria,2J6CH@203691|Spirochaetes	203691|Spirochaetes	S	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
CMS1_k127_1878817_17	158190.SpiGrapes_1451	4.87e-115	376.0	COG2186@1|root,COG2186@2|Bacteria	2|Bacteria	K	Transcriptional regulator	ycbG	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_1878817_0	158190.SpiGrapes_1452	0.0	1583.0	COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,2J6TA@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.64,5.4.2.6	ko:K01838,ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727,R02728,R11310	RC00049,RC00408	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
CMS1_k127_1878817_15	906968.Trebr_0424	1.468e-145	466.0	COG0395@1|root,COG0395@2|Bacteria,2J5Z6@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119,ko:K10234	ko02010,map02010	M00196,M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
CMS1_k127_1878817_14	906968.Trebr_0423	1.002e-152	490.0	COG1175@1|root,COG1175@2|Bacteria,2J5SW@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10233	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
CMS1_k127_1878817_5	906968.Trebr_0422	7.195e-218	681.0	COG1653@1|root,COG1653@2|Bacteria,2J6W1@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1
CMS1_k127_1878817_11	158190.SpiGrapes_1453	2.082e-165	525.0	COG1609@1|root,COG1609@2|Bacteria,2J63Y@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_1878817_18	158190.SpiGrapes_1457	6.55e-93	310.0	COG0252@1|root,COG0252@2|Bacteria,2J7ZE@203691|Spirochaetes	203691|Spirochaetes	EJ	PFAM Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
CMS1_k127_1878817_12	158190.SpiGrapes_1458	1.61e-162	515.0	COG2084@1|root,COG2084@2|Bacteria,2J6T0@203691|Spirochaetes	203691|Spirochaetes	I	PFAM NAD binding domain of 6-phosphogluconate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
CMS1_k127_1878817_8	158190.SpiGrapes_1459	4.509e-180	566.0	COG3958@1|root,COG3958@2|Bacteria,2J64Y@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Transketolase, C-terminal domain	tkt'	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS1_k127_1878817_10	158190.SpiGrapes_1460	1.486e-170	536.0	COG3959@1|root,COG3959@2|Bacteria,2J7TK@203691|Spirochaetes	203691|Spirochaetes	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS1_k127_1894067_2	158190.SpiGrapes_2220	1.243e-79	269.0	COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS1_k127_1894067_3	158190.SpiGrapes_2219	2.307e-65	225.0	COG1725@1|root,COG1725@2|Bacteria,2J9B8@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS1_k127_1894067_0	158190.SpiGrapes_2218	3.571e-176	559.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS1_k127_1894067_1	158190.SpiGrapes_2217	3.759e-122	396.0	COG1136@1|root,COG1136@2|Bacteria,2J7FN@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_1894067_4	158190.SpiGrapes_2216	5.336e-35	134.0	COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS1_k127_1905118_4	158190.SpiGrapes_1744	3.805e-114	370.0	COG1802@1|root,COG1802@2|Bacteria,2J64I@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_1905118_0	158190.SpiGrapes_1685	0.0	1413.0	COG1501@1|root,COG1501@2|Bacteria,2J722@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
CMS1_k127_1905118_3	1499967.BAYZ01000108_gene2201	3.609e-117	382.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026,ko:K10119	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_1905118_1	158190.SpiGrapes_1687	6.777e-180	565.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10189,ko:K10228,ko:K15771,ko:K17242,ko:K17316	ko02010,map02010	M00196,M00198,M00199,M00200,M00207,M00491,M00600,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.39,3.A.1.1.4,3.A.1.1.5	-	-	BPD_transp_1
CMS1_k127_1905118_2	158190.SpiGrapes_1688	4.174e-173	543.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027,ko:K10117	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_1915205_1	1114922.CIFAM_04_03380	1.082e-106	349.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,1RRV3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	-	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
CMS1_k127_1915205_2	1121335.Clst_0277	2.544e-84	290.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3WHF9@541000|Ruminococcaceae	186801|Clostridia	GK	Psort location Cytoplasmic, score	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
CMS1_k127_1915205_3	573413.Spirs_3624	7.127e-82	284.0	COG4213@1|root,COG4213@2|Bacteria	2|Bacteria	G	D-xylose transmembrane transport	-	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
CMS1_k127_1915205_0	580327.Tthe_2370	3.42e-157	510.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,42ESS@68295|Thermoanaerobacterales	186801|Clostridia	P	Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system	xylG	-	3.6.3.17	ko:K10441,ko:K10545	ko02010,map02010	M00212,M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4	-	-	ABC_tran
CMS1_k127_192266_3	1123242.JH636435_gene2071	1.52e-48	184.0	COG1609@1|root,COG1609@2|Bacteria,2J18R@203682|Planctomycetes	203682|Planctomycetes	K	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_3
CMS1_k127_192266_4	1121115.AXVN01000108_gene621	5.194e-48	176.0	COG0346@1|root,COG0346@2|Bacteria,1V7XP@1239|Firmicutes,24KYI@186801|Clostridia,3Y0HK@572511|Blautia	186801|Clostridia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
CMS1_k127_192266_2	180332.JTGN01000001_gene5340	1.641e-54	208.0	COG1070@1|root,COG1070@2|Bacteria,1TSEJ@1239|Firmicutes,24AT3@186801|Clostridia	186801|Clostridia	G	Carbohydrate kinase, FGGY family protein	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
CMS1_k127_192266_1	158190.SpiGrapes_1471	5.662e-161	512.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,2J7G6@203691|Spirochaetes	203691|Spirochaetes	K	SMART Helix-turn-helix, AraC type, DNA binding domain	-	-	-	ko:K02854,ko:K02855	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18
CMS1_k127_192266_0	158190.SpiGrapes_1472	1.023e-230	716.0	COG1454@1|root,COG1454@2|Bacteria,2J5QM@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
CMS1_k127_1923352_5	742733.HMPREF9469_04354	1.271e-08	63.0	COG2972@1|root,COG2972@2|Bacteria,1V051@1239|Firmicutes,24D7M@186801|Clostridia,21ZUK@1506553|Lachnoclostridium	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,dCache_1
CMS1_k127_1923352_3	742733.HMPREF9469_04353	6.641e-72	250.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V1IV@1239|Firmicutes,249XP@186801|Clostridia,21YG1@1506553|Lachnoclostridium	186801|Clostridia	KT	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
CMS1_k127_1923352_1	742733.HMPREF9469_04352	5.718e-136	439.0	COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,248DR@186801|Clostridia,21XFE@1506553|Lachnoclostridium	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10193	ko02010,map02010	M00202	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.11	-	-	BPD_transp_1
CMS1_k127_1923352_2	742733.HMPREF9469_04351	5.84e-120	392.0	COG0395@1|root,COG0395@2|Bacteria,1TSYB@1239|Firmicutes,24AKM@186801|Clostridia,21XS2@1506553|Lachnoclostridium	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10194	ko02010,map02010	M00202	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.11	-	-	BPD_transp_1
CMS1_k127_1923352_4	545695.TREAZ_2887	4.685e-49	185.0	COG2220@1|root,COG2220@2|Bacteria,2J9HQ@203691|Spirochaetes	203691|Spirochaetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS1_k127_1923352_0	158190.SpiGrapes_1721	6.748e-142	451.0	COG1414@1|root,COG1414@2|Bacteria,2J7GJ@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
CMS1_k127_1942927_12	33035.JPJF01000040_gene5180	1.88e-29	121.0	COG0395@1|root,COG0395@2|Bacteria,1TRGH@1239|Firmicutes,24C7R@186801|Clostridia	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_1942927_7	33035.JPJF01000040_gene5181	9.17e-113	372.0	COG1175@1|root,COG1175@2|Bacteria,1TSRA@1239|Firmicutes,24E4R@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17238	ko02010,map02010	M00599	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.38	-	-	BPD_transp_1
CMS1_k127_1942927_3	33035.JPJF01000040_gene5182	2.241e-174	557.0	COG1653@1|root,COG1653@2|Bacteria,1U0GS@1239|Firmicutes,24DMA@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_1942927_13	907348.TresaDRAFT_0599	4.802e-05	47.0	2AW08@1|root,31MUQ@2|Bacteria,2JB5R@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1942927_4	158190.SpiGrapes_2213	8.194e-133	432.0	2EG9W@1|root,33A1P@2|Bacteria,2J9F9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1942927_11	1499967.BAYZ01000167_gene6761	8.175e-34	141.0	COG2834@1|root,COG2834@2|Bacteria,2NQGF@2323|unclassified Bacteria	2|Bacteria	M	MucB/RseB N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS1_k127_1942927_2	158190.SpiGrapes_2215	1.47e-197	622.0	COG4591@1|root,COG4591@2|Bacteria,2JA02@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS1_k127_1942927_1	158190.SpiGrapes_2216	5.998e-218	681.0	COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS1_k127_1942927_9	158190.SpiGrapes_2222	2.123e-91	302.0	COG1528@1|root,COG1528@2|Bacteria,2J7RS@203691|Spirochaetes	203691|Spirochaetes	P	Iron-storage protein	rsgA	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
CMS1_k127_1942927_0	158190.SpiGrapes_2223	6.973e-234	729.0	COG0168@1|root,COG0168@2|Bacteria,2J5NF@203691|Spirochaetes	203691|Spirochaetes	P	Potassium uptake protein, TrkH family	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS1_k127_1942927_5	158190.SpiGrapes_2224	1.329e-119	386.0	COG0569@1|root,COG0569@2|Bacteria,2J72B@203691|Spirochaetes	203691|Spirochaetes	C	domain protein	tkrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS1_k127_1942927_10	158190.SpiGrapes_2225	2.932e-72	247.0	COG0663@1|root,COG0663@2|Bacteria,2J7Q4@203691|Spirochaetes	203691|Spirochaetes	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
CMS1_k127_1942927_6	158190.SpiGrapes_2227	4.014e-115	379.0	COG0803@1|root,COG0803@2|Bacteria,2J6TS@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
CMS1_k127_1942927_8	158190.SpiGrapes_2228	6.11e-96	317.0	COG1121@1|root,COG1121@2|Bacteria,2J6HR@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	znuC	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
CMS1_k127_1958844_21	158190.SpiGrapes_2556	9.594e-166	528.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,2JANG@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS1_k127_1958844_65	536232.CLM_0420	2.359e-50	188.0	COG0745@1|root,COG0745@2|Bacteria,1TPN8@1239|Firmicutes,248UA@186801|Clostridia,36F08@31979|Clostridiaceae	186801|Clostridia	T	response regulator	phoP	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_1958844_24	158190.SpiGrapes_2554	2.777e-162	516.0	COG3053@1|root,COG3053@2|Bacteria,2J9SJ@203691|Spirochaetes	203691|Spirochaetes	H	Citrate lyase ligase C-domain protein	-	-	6.2.1.22	ko:K01910	ko02020,map02020	-	R04449	RC00012,RC00039	ko00000,ko00001,ko01000	-	-	-	Citrate_ly_lig
CMS1_k127_1958844_11	158190.SpiGrapes_2553	1.426e-277	854.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CMS1_k127_1958844_30	158190.SpiGrapes_2552	5.151e-140	451.0	COG0454@1|root,COG0456@2|Bacteria,2J74W@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,UPF0158
CMS1_k127_1958844_39	158190.SpiGrapes_2551	8.415e-122	394.0	COG0363@1|root,COG0363@2|Bacteria	2|Bacteria	G	glucosamine-6-phosphate deaminase activity	nagB	-	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
CMS1_k127_1958844_14	158190.SpiGrapes_2550	4.053e-225	699.0	COG1312@1|root,COG1312@2|Bacteria,2J5RS@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the dehydration of D-mannonate	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
CMS1_k127_1958844_44	158190.SpiGrapes_2549	5.227e-108	356.0	COG1802@1|root,COG1802@2|Bacteria,2J7H2@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_1958844_9	158190.SpiGrapes_2548	1.846e-302	932.0	COG0246@1|root,COG0246@2|Bacteria,2J5CB@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Mannitol dehydrogenase C-terminal	mtlD2	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
CMS1_k127_1958844_20	158190.SpiGrapes_2547	1.557e-168	534.0	COG1284@1|root,COG1284@2|Bacteria,2J5TB@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
CMS1_k127_1958844_68	891974.E05_24290	1.742e-25	115.0	COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,1RS5C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	effector of murein hydrolase	yohK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LrgB
CMS1_k127_1958844_67	158190.SpiGrapes_2545	3.427e-47	172.0	COG1380@1|root,COG1380@2|Bacteria,2J8SG@203691|Spirochaetes	203691|Spirochaetes	S	effector of murein hydrolase LrgA	lrgA	-	-	ko:K06518	-	-	-	-	ko00000,ko02000	1.E.14.2	-	-	LrgA
CMS1_k127_1958844_52	158190.SpiGrapes_2544	1.542e-83	279.0	COG0778@1|root,COG0778@2|Bacteria,2J6P8@203691|Spirochaetes	203691|Spirochaetes	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS1_k127_1958844_25	158190.SpiGrapes_2538	5.603e-160	510.0	COG1864@1|root,COG1864@2|Bacteria,2J7IP@203691|Spirochaetes	203691|Spirochaetes	V	DNA RNA non-specific endonuclease	nucA	-	-	ko:K01173	ko04210,map04210	-	-	-	ko00000,ko00001,ko03029	-	-	-	Endonuclease_NS
CMS1_k127_1958844_29	158190.SpiGrapes_2521	1.879e-144	459.0	COG0467@1|root,COG0467@2|Bacteria,2J5KM@203691|Spirochaetes	203691|Spirochaetes	T	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25,ATPase
CMS1_k127_1958844_1	158190.SpiGrapes_2520	0.0	1320.0	COG0480@1|root,COG0480@2|Bacteria,2J5M8@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS1_k127_1958844_60	158190.SpiGrapes_2519	1.388e-69	238.0	COG0537@1|root,COG0537@2|Bacteria,2J92I@203691|Spirochaetes	203691|Spirochaetes	FG	histidine triad	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
CMS1_k127_1958844_33	158190.SpiGrapes_2517	1.99e-138	458.0	COG3064@1|root,COG3064@2|Bacteria	2|Bacteria	M	translation initiation factor activity	-	-	-	ko:K08307,ko:K19140	-	-	-	-	ko00000,ko01000,ko01011,ko02048	-	-	-	DDE_Tnp_1,DUF772
CMS1_k127_1958844_54	158190.SpiGrapes_2516	3.642e-79	269.0	2C52S@1|root,2ZQT0@2|Bacteria,2J8CH@203691|Spirochaetes	203691|Spirochaetes	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
CMS1_k127_1958844_46	158190.SpiGrapes_2515	1.074e-87	295.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	yjjG	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.102,3.1.3.104,3.1.3.5,3.8.1.2	ko:K01560,ko:K07025,ko:K08723,ko:K20862	ko00230,ko00240,ko00361,ko00625,ko00740,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00740,map00760,map01100,map01110,map01120	M00125	R00183,R00511,R00548,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R05287,R07280	RC00017,RC00697	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_4614	HAD_2
CMS1_k127_1958844_37	158190.SpiGrapes_2514	1.64e-128	417.0	COG0545@1|root,COG0545@2|Bacteria,2J77J@203691|Spirochaetes	203691|Spirochaetes	M	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
CMS1_k127_1958844_63	1280680.AUJU01000017_gene3924	2.033e-54	196.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,4BWM3@830|Butyrivibrio	186801|Clostridia	C	Fumarase C-terminus	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
CMS1_k127_1958844_34	158190.SpiGrapes_2512	2.22e-135	436.0	COG1951@1|root,COG1951@2|Bacteria,2J747@203691|Spirochaetes	203691|Spirochaetes	C	Fumarate hydratase	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
CMS1_k127_1958844_69	83406.HDN1F_00200	5.102e-05	52.0	29QWA@1|root,30BWM@2|Bacteria,1REIR@1224|Proteobacteria,1S50N@1236|Gammaproteobacteria,1J7C2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CBM_11,VanZ
CMS1_k127_1958844_19	158190.SpiGrapes_2510	1.414e-168	536.0	COG1242@1|root,COG1242@2|Bacteria,2J6Y8@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM radical SAM protein, TIGR01212 family	-	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
CMS1_k127_1958844_6	158190.SpiGrapes_2509	0.0	1013.0	COG1752@1|root,COG1752@2|Bacteria,2J6JW@203691|Spirochaetes	203691|Spirochaetes	M	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,Patatin
CMS1_k127_1958844_27	158190.SpiGrapes_2508	1.004e-148	476.0	COG0223@1|root,COG0223@2|Bacteria,2J621@203691|Spirochaetes	203691|Spirochaetes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS1_k127_1958844_53	158190.SpiGrapes_2507	2.537e-80	270.0	COG0242@1|root,COG0242@2|Bacteria,2J7X0@203691|Spirochaetes	203691|Spirochaetes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CMS1_k127_1958844_4	158190.SpiGrapes_2506	0.0	1147.0	COG1198@1|root,COG1198@2|Bacteria,2J5B4@203691|Spirochaetes	203691|Spirochaetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
CMS1_k127_1958844_59	760011.Spico_1452	1.662e-70	248.0	COG1573@1|root,COG1573@2|Bacteria,2J612@203691|Spirochaetes	203691|Spirochaetes	L	Uracil-DNA glycosylase, family 4	ung	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS1_k127_1958844_26	158190.SpiGrapes_2504	2.399e-151	482.0	COG0101@1|root,COG0101@2|Bacteria,2J65Z@203691|Spirochaetes	203691|Spirochaetes	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
CMS1_k127_1958844_66	158190.SpiGrapes_2503	1.93e-49	180.0	COG0736@1|root,COG0736@2|Bacteria	2|Bacteria	I	holo-[acyl-carrier-protein] synthase activity	acpS	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	2.7.8.7,3.2.1.52	ko:K00997,ko:K01207	ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501	M00628	R00022,R01625,R05963,R07809,R07810,R10831	RC00002,RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	ACPS
CMS1_k127_1958844_22	158190.SpiGrapes_2501	1.328e-164	520.0	COG1624@1|root,COG1624@2|Bacteria,2J5ZB@203691|Spirochaetes	203691|Spirochaetes	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
CMS1_k127_1958844_10	158190.SpiGrapes_2500	4.833e-300	924.0	COG0554@1|root,COG0554@2|Bacteria,2J6GI@203691|Spirochaetes	203691|Spirochaetes	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
CMS1_k127_1958844_15	158190.SpiGrapes_2499	4.158e-187	596.0	COG0666@1|root,COG0666@2|Bacteria,2JAR3@203691|Spirochaetes	203691|Spirochaetes	S	Ankyrin repeat	-	-	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank_2,Ank_4
CMS1_k127_1958844_38	158190.SpiGrapes_2498	2.483e-124	412.0	COG1752@1|root,COG1752@2|Bacteria,2J9D4@203691|Spirochaetes	203691|Spirochaetes	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
CMS1_k127_1958844_61	158189.SpiBuddy_2295	3.97e-59	206.0	COG4109@1|root,COG4109@2|Bacteria,2J8FH@203691|Spirochaetes	203691|Spirochaetes	K	PFAM DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
CMS1_k127_1958844_57	158190.SpiGrapes_2496	2.057e-74	251.0	COG2172@1|root,COG2172@2|Bacteria,2JANB@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CMS1_k127_1958844_43	1123274.KB899426_gene2776	3.514e-109	369.0	COG1145@1|root,COG4624@1|root,COG4871@1|root,COG1145@2|Bacteria,COG4624@2|Bacteria,COG4871@2|Bacteria,2J7UK@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4
CMS1_k127_1958844_0	158190.SpiGrapes_2494	0.0	1659.0	COG1026@1|root,COG1026@2|Bacteria,2J67R@203691|Spirochaetes	203691|Spirochaetes	S	peptidase, M16	-	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
CMS1_k127_1958844_35	158190.SpiGrapes_2493	5.661e-134	432.0	COG0648@1|root,COG0648@2|Bacteria,2J7XJ@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
CMS1_k127_1958844_32	158190.SpiGrapes_2492	1.094e-138	444.0	COG0584@1|root,COG0584@2|Bacteria,2J6RW@203691|Spirochaetes	203691|Spirochaetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS1_k127_1958844_16	158190.SpiGrapes_2491	5.296e-184	589.0	2CAZD@1|root,342TQ@2|Bacteria,2J9GV@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1958844_13	158190.SpiGrapes_2489	5.994e-228	710.0	COG2195@1|root,COG2195@2|Bacteria,2J59I@203691|Spirochaetes	203691|Spirochaetes	E	Cleaves the N-terminal amino acid of tripeptides	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
CMS1_k127_1958844_62	158190.SpiGrapes_2484	9.172e-55	198.0	COG1762@1|root,COG1762@2|Bacteria,2J7FM@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
CMS1_k127_1958844_7	158190.SpiGrapes_2483	0.0	1010.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
CMS1_k127_1958844_12	158190.SpiGrapes_2482	7.193e-258	798.0	COG0364@1|root,COG0364@2|Bacteria,2J6N0@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
CMS1_k127_1958844_50	158190.SpiGrapes_2481	2.58e-84	285.0	COG0363@1|root,COG0363@2|Bacteria,2JAWD@203691|Spirochaetes	203691|Spirochaetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
CMS1_k127_1958844_28	158190.SpiGrapes_2480	1.874e-148	478.0	COG2199@1|root,COG3706@2|Bacteria,2JAXV@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_1958844_5	158190.SpiGrapes_2479	0.0	1133.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6WY@203691|Spirochaetes	203691|Spirochaetes	C	Iron only hydrogenase large subunit, C-terminal domain	hymC	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3
CMS1_k127_1958844_3	158190.SpiGrapes_2478	0.0	1200.0	COG1894@1|root,COG1894@2|Bacteria,2J5MT@203691|Spirochaetes	203691|Spirochaetes	C	NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
CMS1_k127_1958844_55	158190.SpiGrapes_2477	3.166e-77	259.0	COG3411@1|root,COG3411@2|Bacteria,2J7XQ@203691|Spirochaetes	203691|Spirochaetes	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS1_k127_1958844_47	158190.SpiGrapes_2476	1.246e-87	294.0	COG0642@1|root,COG2205@2|Bacteria,2J8FP@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CMS1_k127_1958844_48	158190.SpiGrapes_2475	1.485e-86	290.0	COG1905@1|root,COG1905@2|Bacteria,2J7IH@203691|Spirochaetes	203691|Spirochaetes	C	Respiratory-chain NADH dehydrogenase 24 Kd subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS1_k127_1958844_36	158190.SpiGrapes_2474	5.293e-132	422.0	COG2344@1|root,COG2344@2|Bacteria,2J89C@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS1_k127_1958844_23	158190.SpiGrapes_2473	2.429e-162	516.0	COG3568@1|root,COG3568@2|Bacteria,2J7FP@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Endonuclease Exonuclease phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS1_k127_1958844_2	158190.SpiGrapes_2472	0.0	1216.0	COG0477@1|root,COG1413@1|root,COG1413@2|Bacteria,COG2814@2|Bacteria,2J5U6@203691|Spirochaetes	203691|Spirochaetes	CG	transporter, major facilitator family	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,MFS_1
CMS1_k127_1958844_45	158190.SpiGrapes_2471	2.165e-100	329.0	COG0740@1|root,COG0740@2|Bacteria,2J78H@203691|Spirochaetes	203691|Spirochaetes	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP-2	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS1_k127_1958844_18	158190.SpiGrapes_2470	4.028e-171	540.0	COG1159@1|root,COG1159@2|Bacteria,2J671@203691|Spirochaetes	203691|Spirochaetes	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
CMS1_k127_1958844_41	158190.SpiGrapes_2469	2.386e-117	380.0	COG0655@1|root,COG0655@2|Bacteria,2J7MG@203691|Spirochaetes	203691|Spirochaetes	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS1_k127_1958844_8	158190.SpiGrapes_2468	3.5e-323	991.0	COG1384@1|root,COG1384@2|Bacteria,2J5WX@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f,tRNA-synt_1g
CMS1_k127_1958844_40	158190.SpiGrapes_2467	1.303e-120	390.0	COG0797@1|root,COG0797@2|Bacteria,2J8E5@203691|Spirochaetes	203691|Spirochaetes	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
CMS1_k127_1958844_51	158190.SpiGrapes_2465	3.937e-84	284.0	2E7HH@1|root,33200@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1958844_17	158190.SpiGrapes_2463	1.757e-179	570.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA,POTRA_2
CMS1_k127_1969229_1	33035.JPJF01000019_gene4239	1.372e-121	396.0	COG1063@1|root,COG1063@2|Bacteria,1VCXY@1239|Firmicutes,24U9W@186801|Clostridia	186801|Clostridia	E	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N
CMS1_k127_1969229_0	33035.JPJF01000019_gene4240	3.669e-139	449.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_200271_2	158190.SpiGrapes_1285	3.277e-77	261.0	COG1653@1|root,COG1653@2|Bacteria,2J8S2@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K02027,ko:K05813	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	SBP_bac_8
CMS1_k127_200271_1	158190.SpiGrapes_1284	9.301e-127	416.0	COG0395@1|root,COG0395@2|Bacteria,2J7F3@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
CMS1_k127_200271_0	158190.SpiGrapes_1283	8.322e-143	457.0	COG1175@1|root,COG1175@2|Bacteria,2JAB7@203691|Spirochaetes	203691|Spirochaetes	P	inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
CMS1_k127_20044_12	158190.SpiGrapes_1908	9.606e-192	602.0	COG0524@1|root,COG0524@2|Bacteria,2J8TE@203691|Spirochaetes	203691|Spirochaetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS1_k127_20044_6	158190.SpiGrapes_1907	4.307e-245	762.0	COG0766@1|root,COG0766@2|Bacteria,2J5JB@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
CMS1_k127_20044_15	158190.SpiGrapes_1906	4.029e-144	467.0	COG2204@1|root,COG2204@2|Bacteria,2J85T@203691|Spirochaetes	203691|Spirochaetes	K	PFAM RNA polymerase sigma factor 54, interaction	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
CMS1_k127_20044_16	158190.SpiGrapes_1905	2.36e-126	408.0	COG1385@1|root,COG1385@2|Bacteria,2J7WH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
CMS1_k127_20044_5	158190.SpiGrapes_1904	6.614e-257	797.0	COG0793@1|root,COG0793@2|Bacteria,2J5QD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
CMS1_k127_20044_13	158190.SpiGrapes_1903	4.354e-190	596.0	COG0682@1|root,COG0682@2|Bacteria,2J58I@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS1_k127_20044_3	158190.SpiGrapes_1902	0.0	1009.0	COG0006@1|root,COG0006@2|Bacteria,2J5QB@203691|Spirochaetes	203691|Spirochaetes	E	peptidase	pepP	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
CMS1_k127_20044_2	158190.SpiGrapes_1901	0.0	1027.0	COG0696@1|root,COG0696@2|Bacteria,2J5QJ@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,iPGM_N
CMS1_k127_20044_10	158190.SpiGrapes_1898	6.004e-209	653.0	COG1609@1|root,COG1609@2|Bacteria,2JACW@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_20044_7	158190.SpiGrapes_1897	7.175e-243	754.0	COG0128@1|root,COG0128@2|Bacteria,2J6P5@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
CMS1_k127_20044_11	158190.SpiGrapes_1896	3.688e-192	602.0	COG2358@1|root,COG2358@2|Bacteria,2J705@203691|Spirochaetes	2|Bacteria	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
CMS1_k127_20044_4	158190.SpiGrapes_1895	0.0	1005.0	COG4666@1|root,COG4666@2|Bacteria,2J57Z@203691|Spirochaetes	2|Bacteria	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS1_k127_20044_9	158190.SpiGrapes_1893	1.72e-219	686.0	COG1301@1|root,COG1301@2|Bacteria,2J6P3@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
CMS1_k127_20044_1	158190.SpiGrapes_1892	0.0	1857.0	COG0366@1|root,COG0366@2|Bacteria,2J649@203691|Spirochaetes	203691|Spirochaetes	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
CMS1_k127_20044_19	158190.SpiGrapes_1891	7.686e-79	270.0	COG0193@1|root,COG0193@2|Bacteria,2J8P8@203691|Spirochaetes	203691|Spirochaetes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	ABM,Pept_tRNA_hydro
CMS1_k127_20044_21	158190.SpiGrapes_1890	1.814e-53	190.0	COG3323@1|root,COG3323@2|Bacteria,2J96M@203691|Spirochaetes	203691|Spirochaetes	L	Protein of unknown function (DUF1653)	glnK	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_20044_8	158190.SpiGrapes_1889	5.43e-236	732.0	COG1900@1|root,COG1900@2|Bacteria,2J6WE@203691|Spirochaetes	203691|Spirochaetes	S	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
CMS1_k127_20044_20	158190.SpiGrapes_1888	1.701e-74	251.0	COG1135@1|root,COG1143@1|root,COG1135@2|Bacteria,COG1143@2|Bacteria,2J8TM@203691|Spirochaetes	203691|Spirochaetes	C	PFAM NIL domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
CMS1_k127_20044_17	158190.SpiGrapes_1887	1.021e-117	382.0	COG2122@1|root,COG2122@2|Bacteria,2J950@203691|Spirochaetes	203691|Spirochaetes	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
CMS1_k127_20044_0	158190.SpiGrapes_1886	0.0	1906.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2J5B2@203691|Spirochaetes	203691|Spirochaetes	H	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
CMS1_k127_20044_14	158190.SpiGrapes_1885	3.743e-177	558.0	COG0685@1|root,COG0685@2|Bacteria,2J5WU@203691|Spirochaetes	203691|Spirochaetes	C	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
CMS1_k127_2006564_23	158190.SpiGrapes_2582	4.118e-163	514.0	COG1879@1|root,COG1879@2|Bacteria,2J7XC@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM rhamnose ABC transporter, rhamnose-binding	-	-	-	ko:K10559	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	Peripla_BP_4
CMS1_k127_2006564_4	158190.SpiGrapes_2583	1.762e-278	863.0	COG1129@1|root,COG1129@2|Bacteria,2J6Z7@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10562	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.9	-	-	ABC_tran
CMS1_k127_2006564_25	760011.Spico_1657	6.31e-135	437.0	COG1172@1|root,COG1172@2|Bacteria,2J826@203691|Spirochaetes	203691|Spirochaetes	P	transport system permease	-	-	-	ko:K10560	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
CMS1_k127_2006564_20	158190.SpiGrapes_2585	1.554e-183	579.0	COG1172@1|root,COG1172@2|Bacteria,2J84S@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K10561	ko02010,map02010	M00212,M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9	-	-	BPD_transp_2
CMS1_k127_2006564_37	158190.SpiGrapes_2586	3.684e-50	180.0	COG3254@1|root,COG3254@2|Bacteria,2J95S@203691|Spirochaetes	203691|Spirochaetes	G	Involved in the anomeric conversion of L-rhamnose	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
CMS1_k127_2006564_24	158190.SpiGrapes_2587	6.214e-146	464.0	COG1349@1|root,COG1349@2|Bacteria,2J5H8@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, DeoR family	-	-	-	ko:K02081,ko:K02436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
CMS1_k127_2006564_17	158190.SpiGrapes_2588	5.477e-198	626.0	COG0508@1|root,COG0508@2|Bacteria,2J686@203691|Spirochaetes	203691|Spirochaetes	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
CMS1_k127_2006564_6	158190.SpiGrapes_2589	5.277e-253	784.0	COG1249@1|root,COG1249@2|Bacteria,2J67A@203691|Spirochaetes	203691|Spirochaetes	C	Dihydrolipoyl dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS1_k127_2006564_0	158190.SpiGrapes_2590	0.0	1553.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2J76K@203691|Spirochaetes	203691|Spirochaetes	C	Dehydrogenase E1 component	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
CMS1_k127_2006564_9	158190.SpiGrapes_2591	6.287e-223	698.0	COG0613@1|root,COG0613@2|Bacteria,2J6D0@203691|Spirochaetes	203691|Spirochaetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2006564_13	158190.SpiGrapes_2592	2.05e-210	657.0	COG1028@1|root,COG1028@2|Bacteria,2J6IK@203691|Spirochaetes	203691|Spirochaetes	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
CMS1_k127_2006564_7	158190.SpiGrapes_2593	5.552e-250	775.0	COG1063@1|root,COG1063@2|Bacteria,2J6QC@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_2006564_5	158190.SpiGrapes_2594	5.212e-260	808.0	COG1070@1|root,COG1070@2|Bacteria,2J7E7@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_2006564_38	158190.SpiGrapes_2597	0.0008483	42.0	COG1172@1|root,COG1172@2|Bacteria,2JBGR@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10541,ko:K17214	ko02010,map02010	M00214,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.3	-	-	BPD_transp_2
CMS1_k127_2006564_18	158190.SpiGrapes_2598	1.57e-190	599.0	COG1609@1|root,COG1609@2|Bacteria,2J6QG@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_2006564_8	158190.SpiGrapes_2599	9.077e-235	730.0	COG1063@1|root,COG1063@2|Bacteria,2J6TI@203691|Spirochaetes	203691|Spirochaetes	C	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K18369	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_2006564_16	158190.SpiGrapes_2600	9.025e-204	638.0	COG0656@1|root,COG0656@2|Bacteria,2J5TE@203691|Spirochaetes	203691|Spirochaetes	C	Aldo/keto reductase family	-	-	1.1.1.2	ko:K00002	ko00010,ko00040,ko00561,ko00930,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00561,map00930,map01100,map01110,map01120,map01130,map01220	M00014	R00746,R01041,R01481,R05231	RC00087,RC00088,RC00099,RC00108	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Aldo_ket_red
CMS1_k127_2006564_12	158190.SpiGrapes_2601	1.816e-211	661.0	COG1609@1|root,COG4977@1|root,COG1609@2|Bacteria,COG4977@2|Bacteria,2J9Z3@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18,Peripla_BP_3
CMS1_k127_2006564_26	158190.SpiGrapes_2602	5.601e-129	415.0	COG0176@1|root,COG0176@2|Bacteria,2J85H@203691|Spirochaetes	203691|Spirochaetes	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
CMS1_k127_2006564_28	158190.SpiGrapes_2603	1.011e-123	406.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	3.1.1.5,4.2.2.6	ko:K01730,ko:K10804	ko00040,ko01040,map00040,map01040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000,ko01004	-	-	-	CBM_35,FR47,Glyco_hydro_88,Lipase_GDSL_2
CMS1_k127_2006564_29	1298593.TOL_1504	7.973e-102	338.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,1RSP8@1236|Gammaproteobacteria,1XJN1@135619|Oceanospirillales	135619|Oceanospirillales	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
CMS1_k127_2006564_36	158189.SpiBuddy_0992	4.005e-51	184.0	COG3422@1|root,COG3422@2|Bacteria,2J9C1@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF1508)	-	-	-	ko:K09946	-	-	-	-	ko00000	-	-	-	DUF1508
CMS1_k127_2006564_11	158190.SpiGrapes_2604	1.423e-213	668.0	COG1168@1|root,COG1168@2|Bacteria,2J65Q@203691|Spirochaetes	203691|Spirochaetes	E	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_2006564_27	158190.SpiGrapes_2605	3.654e-124	402.0	COG0716@1|root,COG1145@1|root,COG0716@2|Bacteria,COG1145@2|Bacteria,2J5IX@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Flavodoxin_5
CMS1_k127_2006564_21	158190.SpiGrapes_2606	1.064e-181	574.0	COG2008@1|root,COG2008@2|Bacteria,2J5XX@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
CMS1_k127_2006564_10	158190.SpiGrapes_2607	1.137e-213	673.0	COG0128@1|root,COG0128@2|Bacteria,2J6P5@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
CMS1_k127_2006564_2	158190.SpiGrapes_2608	0.0	1048.0	COG4166@1|root,COG4166@2|Bacteria,2J687@203691|Spirochaetes	203691|Spirochaetes	E	extracellular solute-binding protein, family 5	oppA-1	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
CMS1_k127_2006564_14	158190.SpiGrapes_2610	3.613e-209	653.0	COG4608@1|root,COG4608@2|Bacteria,2J5YH@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_2006564_15	158190.SpiGrapes_2611	1.18e-205	642.0	COG0444@1|root,COG0444@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_2006564_3	158190.SpiGrapes_2612	1.956e-289	894.0	COG1173@1|root,COG1173@2|Bacteria,2J57E@203691|Spirochaetes	203691|Spirochaetes	EP	ABC transporter (Permease)	oppC-1	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
CMS1_k127_2006564_19	158190.SpiGrapes_2613	4.314e-185	581.0	COG0601@1|root,COG0601@2|Bacteria,2J601@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter, permease protein	oppB	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
CMS1_k127_2006564_31	264732.Moth_1074	2.632e-88	307.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,42EU2@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
CMS1_k127_2006564_1	158190.SpiGrapes_2615	0.0	1390.0	COG0210@1|root,COG0210@2|Bacteria,2J5EW@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CMS1_k127_2006564_22	158190.SpiGrapes_2616	3.791e-167	527.0	COG0001@1|root,COG0001@2|Bacteria	2|Bacteria	H	glutamate-1-semialdehyde 2,1-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2006564_30	158190.SpiGrapes_2617	1.342e-88	292.0	COG0102@1|root,COG0102@2|Bacteria,2J86Y@203691|Spirochaetes	203691|Spirochaetes	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CMS1_k127_2006564_33	158190.SpiGrapes_2618	5.306e-80	267.0	COG0103@1|root,COG0103@2|Bacteria,2J8A0@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CMS1_k127_2006564_34	158190.SpiGrapes_2619	4.052e-67	233.0	COG2137@1|root,COG2137@2|Bacteria	2|Bacteria	S	regulation of DNA repair	recX	GO:0003674,GO:0006282,GO:0008150,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
CMS1_k127_2006564_35	158190.SpiGrapes_2620	6.077e-57	201.0	COG0530@1|root,COG0530@2|Bacteria,2J885@203691|Spirochaetes	203691|Spirochaetes	P	K -dependent Na Ca exchanger	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS1_k127_2020802_1	158190.SpiGrapes_1552	4.21e-169	535.0	COG0673@1|root,COG0673@2|Bacteria,2JAR2@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_2020802_0	158190.SpiGrapes_1553	1.664e-211	661.0	COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK,RadC
CMS1_k127_2020802_6	1437609.BCAL_0929	8.602e-45	174.0	COG3774@1|root,COG3774@2|Bacteria,2ICTC@201174|Actinobacteria,4D0R2@85004|Bifidobacteriales	201174|Actinobacteria	M	Capsular polysaccharide synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caps_synth
CMS1_k127_2020802_5	767817.Desgi_4137	2.177e-48	184.0	COG1215@1|root,COG1215@2|Bacteria,1UI1V@1239|Firmicutes	1239|Firmicutes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_2020802_2	1268072.PSAB_18475	3.479e-144	473.0	COG2244@1|root,COG2244@2|Bacteria,1TR1W@1239|Firmicutes,4HCW6@91061|Bacilli,275PH@186822|Paenibacillaceae	91061|Bacilli	S	Psort location CytoplasmicMembrane, score	cps2I	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
CMS1_k127_2020802_8	479437.Elen_2437	2.634e-35	149.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_2020802_7	1286171.EAL2_c19070	5.231e-40	161.0	COG0463@1|root,COG0463@2|Bacteria,1VVRP@1239|Firmicutes,24AI7@186801|Clostridia	186801|Clostridia	M	Glycosyltransferase, group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_2020802_3	931276.Cspa_c53500	2.293e-62	225.0	COG0438@1|root,COG0438@2|Bacteria,1V2I8@1239|Firmicutes,24ICP@186801|Clostridia,36QJB@31979|Clostridiaceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS1_k127_2034725_1	158190.SpiGrapes_0844	9.352e-81	274.0	2AJWE@1|root,31AJA@2|Bacteria	2|Bacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2034725_0	158189.SpiBuddy_1058	1.805e-139	469.0	COG5001@1|root,COG5001@2|Bacteria,2J5Z5@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,PAS_9
CMS1_k127_2071160_0	1123274.KB899412_gene1427	2.212e-239	743.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	thuE	-	-	ko:K02027,ko:K10236	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2071160_1	1123274.KB899406_gene942	1.305e-30	125.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	thuF	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02025,ko:K10237,ko:K15771	ko02010,map02010	M00204,M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2	-	iNJ661.Rv1236	BPD_transp_1
CMS1_k127_2097684_2	1122925.KB895384_gene3256	1.325e-23	103.0	COG1653@1|root,COG1653@2|Bacteria,1U0GS@1239|Firmicutes,4HB07@91061|Bacilli,26VI3@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2097684_0	1461580.CCAS010000016_gene1993	4.022e-104	346.0	COG1175@1|root,COG1175@2|Bacteria,1TSRA@1239|Firmicutes,4HAUB@91061|Bacilli,1ZD88@1386|Bacillus	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2097684_1	1227349.C170_08330	2.677e-71	249.0	COG0395@1|root,COG0395@2|Bacteria,1TRGH@1239|Firmicutes,4HA23@91061|Bacilli,26WJA@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2098481_0	573413.Spirs_2961	4.009e-175	552.0	COG0385@1|root,COG0385@2|Bacteria	2|Bacteria	S	bile acid:sodium symporter activity	yfeH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.93.1	-	-	SBF_like
CMS1_k127_2098481_1	658086.HMPREF0994_00837	1.894e-155	494.0	COG1373@1|root,COG1373@2|Bacteria,1TQ8Z@1239|Firmicutes,24A83@186801|Clostridia,27JXX@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS1_k127_2120225_1	158190.SpiGrapes_1509	1.108e-163	517.0	COG2207@1|root,COG4936@1|root,COG2207@2|Bacteria,COG4936@2|Bacteria,2J8ZS@203691|Spirochaetes	203691|Spirochaetes	K	AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PocR
CMS1_k127_2120225_0	158190.SpiGrapes_1510	1.903e-191	604.0	COG2334@1|root,COG2334@2|Bacteria,2J750@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
CMS1_k127_2120225_4	1125699.HMPREF9194_01957	7.664e-56	206.0	COG2197@1|root,COG2197@2|Bacteria,2JB0I@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS1_k127_2120225_3	1056512.D515_01840	4.461e-138	457.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1XWRW@135623|Vibrionales	135623|Vibrionales	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
CMS1_k127_2120225_2	1125699.HMPREF9194_01955	1.421e-138	447.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	3.6.3.17	ko:K10440,ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS1_k127_2120225_5	1125699.HMPREF9194_01954	9.721e-12	65.0	COG1129@1|root,COG1129@2|Bacteria	2|Bacteria	G	ABC transporter	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS1_k127_2126795_2	180332.JTGN01000001_gene4785	1.969e-110	366.0	COG1653@1|root,COG1653@2|Bacteria,1TSDX@1239|Firmicutes,25B6Y@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2126795_0	570967.JMLV01000010_gene1223	1.367e-142	470.0	COG0747@1|root,COG0747@2|Bacteria,1MVNT@1224|Proteobacteria,2TRPI@28211|Alphaproteobacteria,2JS0B@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS1_k127_2126795_1	381666.H16_B2463	2.398e-117	402.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,1K2H2@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	dppF	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS1_k127_2126795_4	1231190.NA8A_22296	4.99e-73	257.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TT48@28211|Alphaproteobacteria,43HD1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_2126795_3	1502851.FG93_02235	7.222e-77	266.0	COG1173@1|root,COG1173@2|Bacteria,1MWP1@1224|Proteobacteria,2TSUG@28211|Alphaproteobacteria,3JR90@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_2126795_5	1110502.TMO_3457	7.561e-71	258.0	COG1524@1|root,COG1524@2|Bacteria,1PTI0@1224|Proteobacteria,2TUW7@28211|Alphaproteobacteria,2JWSC@204441|Rhodospirillales	204441|Rhodospirillales	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS1_k127_2145851_6	158190.SpiGrapes_1164	2.696e-45	165.0	COG3461@1|root,COG3461@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09700	-	-	-	-	ko00000	-	-	-	-
CMS1_k127_2145851_0	158189.SpiBuddy_0862	1.361e-272	853.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_49N,Hepar_II_III,Hepar_II_III_N
CMS1_k127_2145851_2	158189.SpiBuddy_0861	7.917e-189	595.0	COG4225@1|root,COG4225@2|Bacteria,2JA04@203691|Spirochaetes	203691|Spirochaetes	S	Glycosyl Hydrolase Family 88	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
CMS1_k127_2145851_4	158189.SpiBuddy_0860	1.849e-141	452.0	COG0395@1|root,COG0395@2|Bacteria,2J7NQ@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2145851_3	158189.SpiBuddy_0859	8.915e-162	513.0	COG1175@1|root,COG1175@2|Bacteria,2J82K@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2145851_1	158189.SpiBuddy_0858	1.428e-223	699.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2145851_5	158189.SpiBuddy_0857	6.48e-90	302.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase
CMS1_k127_2148030_15	158190.SpiGrapes_2556	1.551e-75	259.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,2JANG@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS1_k127_2148030_5	158190.SpiGrapes_2557	2.083e-199	623.0	COG3181@1|root,COG3181@2|Bacteria,2J7TJ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
CMS1_k127_2148030_16	158190.SpiGrapes_2558	3.124e-67	232.0	2E96H@1|root,333F3@2|Bacteria,2J99D@203691|Spirochaetes	203691|Spirochaetes	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
CMS1_k127_2148030_2	158190.SpiGrapes_2559	4.411e-281	868.0	COG3333@1|root,COG3333@2|Bacteria,2J70X@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
CMS1_k127_2148030_17	158190.SpiGrapes_2560	2.836e-42	156.0	COG3052@1|root,COG3052@2|Bacteria,2J90H@203691|Spirochaetes	203691|Spirochaetes	C	Covalent carrier of the coenzyme of citrate lyase	citD	-	-	ko:K01646	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001	-	-	-	ACP
CMS1_k127_2148030_8	158190.SpiGrapes_2561	1.122e-164	520.0	COG2301@1|root,COG2301@2|Bacteria,2J7CN@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS1_k127_2148030_1	158190.SpiGrapes_2562	1.233e-298	920.0	COG3051@1|root,COG3051@2|Bacteria,2J5CP@203691|Spirochaetes	203691|Spirochaetes	H	Citrate (pro-3S)-lyase alpha chain	citF	-	2.8.3.10	ko:K01643	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	CitF
CMS1_k127_2148030_18	158190.SpiGrapes_2563	7.517e-41	157.0	COG3697@1|root,COG3697@2|Bacteria,2J8UT@203691|Spirochaetes	203691|Spirochaetes	HI	synthase CitX	citX	-	2.7.7.61	ko:K05964	ko02020,map02020	-	R10706	-	ko00000,ko00001,ko01000	-	-	-	CitX
CMS1_k127_2148030_13	158190.SpiGrapes_2564	9.962e-110	362.0	COG1767@1|root,COG1767@2|Bacteria,2J823@203691|Spirochaetes	203691|Spirochaetes	H	synthase	citG	-	2.4.2.52,2.7.7.61	ko:K05964,ko:K05966,ko:K13927	ko02020,map02020	-	R09675,R10706	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG,CitX
CMS1_k127_2148030_9	158190.SpiGrapes_2565	5.006e-158	505.0	COG1619@1|root,COG1619@2|Bacteria,2J6NW@203691|Spirochaetes	203691|Spirochaetes	V	LD-carboxypeptidase	ldcA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
CMS1_k127_2148030_4	158190.SpiGrapes_2566	9.151e-201	640.0	COG5297@1|root,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	3.2.1.11	ko:K05988	ko00500,map00500	-	R11309	-	ko00000,ko00001,ko01000	-	GH66	-	CotH,Glyco_hydro_66
CMS1_k127_2148030_10	158190.SpiGrapes_2567	1.426e-147	473.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_2148030_14	658086.HMPREF0994_06140	1.064e-103	346.0	COG1175@1|root,COG1175@2|Bacteria,1TRA3@1239|Firmicutes,24BD8@186801|Clostridia,27JBC@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_2148030_3	158190.SpiGrapes_2569	7.708e-246	763.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	msmE3	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2148030_7	158190.SpiGrapes_2570	3.182e-167	537.0	COG3387@1|root,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	3.2.1.205	ko:K22308	-	-	-	-	ko00000,ko01000	-	GH15	-	Glyco_hydro_15
CMS1_k127_2148030_6	158190.SpiGrapes_2571	1.294e-173	548.0	COG1609@1|root,COG1609@2|Bacteria,2J7A9@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_2148030_12	158190.SpiGrapes_2572	6.34e-115	378.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
CMS1_k127_2148030_0	158190.SpiGrapes_2573	0.0	1381.0	COG2887@1|root,COG2887@2|Bacteria,2J5A3@203691|Spirochaetes	203691|Spirochaetes	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
CMS1_k127_2148030_11	158190.SpiGrapes_2574	4.438e-145	467.0	COG1074@1|root,COG1074@2|Bacteria,2J5IQ@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the helicase family. UvrD subfamily	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
CMS1_k127_2150136_11	556269.ACDQ01000007_gene1809	5.604e-29	122.0	COG2199@1|root,COG2703@1|root,COG2703@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2VSIW@28216|Betaproteobacteria,474EM@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Hemerythrin,PAS_4
CMS1_k127_2150136_0	158190.SpiGrapes_2294	1.13e-229	720.0	COG0534@1|root,COG0534@2|Bacteria,2J5NT@203691|Spirochaetes	203691|Spirochaetes	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_2150136_4	1298920.KI911353_gene4460	5.77e-84	286.0	COG0500@1|root,COG2226@2|Bacteria,1UVHG@1239|Firmicutes,25KIB@186801|Clostridia,221KJ@1506553|Lachnoclostridium	186801|Clostridia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS1_k127_2150136_8	1298920.KI911353_gene4461	1.001e-58	209.0	COG1695@1|root,COG1695@2|Bacteria,1V1R5@1239|Firmicutes,24FU3@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34,PadR,Vir_act_alpha_C
CMS1_k127_2150136_7	158189.SpiBuddy_0990	1.02e-61	215.0	2BQ07@1|root,32IUB@2|Bacteria	2|Bacteria	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
CMS1_k127_2150136_5	158190.SpiGrapes_2747	3.558e-82	276.0	COG1670@1|root,COG1670@2|Bacteria,2J660@203691|Spirochaetes	203691|Spirochaetes	J	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS1_k127_2150136_6	1410676.JNKL01000001_gene951	7.996e-69	249.0	COG2910@1|root,COG2910@2|Bacteria,1MV9B@1224|Proteobacteria,1S0ZG@1236|Gammaproteobacteria,1Y4TZ@135624|Aeromonadales	135624|Aeromonadales	S	NAD(P)H-binding	-	-	-	ko:K07118	-	-	-	-	ko00000	-	-	-	NAD_binding_10
CMS1_k127_2150136_9	1118060.CAGZ01000012_gene7	1.18e-42	161.0	COG1959@1|root,COG1959@2|Bacteria,2IFDS@201174|Actinobacteria,4CXYJ@84998|Coriobacteriia	84998|Coriobacteriia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS1_k127_2150136_1	1121918.ARWE01000001_gene3106	2.393e-209	679.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,42N7P@68525|delta/epsilon subdivisions,2WMCJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	-	DUF2156,LPG_synthase_TM
CMS1_k127_2150136_3	693746.OBV_02080	5.536e-98	334.0	COG1073@1|root,COG1506@1|root,COG1073@2|Bacteria,COG1506@2|Bacteria,1V0DY@1239|Firmicutes,24FC0@186801|Clostridia	186801|Clostridia	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
CMS1_k127_2150136_2	158190.SpiGrapes_2298	7.003e-160	510.0	COG1902@1|root,COG1902@2|Bacteria,2J7Z3@203691|Spirochaetes	203691|Spirochaetes	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.6.99.1	ko:K00354	-	-	R00282	RC00001	ko00000,ko01000	-	-	-	Oxidored_FMN
CMS1_k127_2150136_10	1121456.ATVA01000015_gene2492	1.451e-42	171.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MH92@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,CHASE,DUF3365,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,PilJ,Response_reg,dCache_1
CMS1_k127_2206328_5	158190.SpiGrapes_1029	8.238e-92	303.0	COG0477@1|root,COG0477@2|Bacteria,2JBG8@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_2206328_4	158190.SpiGrapes_1028	1.527e-122	398.0	COG0561@1|root,COG0561@2|Bacteria,2J5FZ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
CMS1_k127_2206328_6	744872.Spica_0369	1.331e-51	188.0	COG1373@1|root,COG1373@2|Bacteria,2J5MK@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS1_k127_2206328_0	158190.SpiGrapes_1027	0.0	1683.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,2J5QM@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	-	-	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
CMS1_k127_2206328_1	158190.SpiGrapes_1026	2.312e-168	536.0	COG4769@1|root,COG4769@2|Bacteria,2J81I@203691|Spirochaetes	203691|Spirochaetes	S	heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
CMS1_k127_2206328_8	1125701.HMPREF1221_02051	1.063e-15	83.0	COG5341@1|root,COG5341@2|Bacteria,2J8UX@203691|Spirochaetes	203691|Spirochaetes	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
CMS1_k127_2206328_2	158190.SpiGrapes_1024	2.187e-144	459.0	COG0745@1|root,COG0745@2|Bacteria,2J63S@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_2206328_3	158190.SpiGrapes_1023	4.074e-136	435.0	COG0745@1|root,COG0745@2|Bacteria,2J63S@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_2206328_7	158190.SpiGrapes_1022	1.864e-51	185.0	COG0642@1|root,COG0642@2|Bacteria	2|Bacteria	T	Histidine kinase	chvG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K07642,ko:K14980,ko:K18143	ko01501,ko02020,map01501,map02020	M00450,M00520,M00645,M00646,M00648,M00649,M00655	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
CMS1_k127_2218166_2	313603.FB2170_03905	1.345e-107	382.0	COG0383@1|root,COG0383@2|Bacteria,4NGF5@976|Bacteroidetes,1I6I3@117743|Flavobacteriia,2PI2E@252356|Maribacter	976|Bacteroidetes	G	Glycosyl hydrolases family 38 C-terminal domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,F5_F8_type_C,Glyco_hydro_38,Glyco_hydro_38C
CMS1_k127_2218166_1	1499967.BAYZ01000016_gene6543	6.753e-121	403.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
CMS1_k127_2218166_4	1499967.BAYZ01000016_gene6544	2.674e-76	265.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
CMS1_k127_2218166_3	1499967.BAYZ01000016_gene6545	1.025e-81	280.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2218166_5	1105031.HMPREF1141_2380	9.831e-66	241.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,36DCB@31979|Clostridiaceae	186801|Clostridia	C	glycyl-radical enzyme activating protein family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_2218166_0	226186.BT_2955	3.642e-254	803.0	COG1882@1|root,COG1882@2|Bacteria,4NDWW@976|Bacteroidetes,2FMC2@200643|Bacteroidia,4APPS@815|Bacteroidaceae	976|Bacteroidetes	C	Pyruvate formate lyase-like	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
CMS1_k127_2218166_7	290402.Cbei_1781	1.931e-12	72.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,36DKQ@31979|Clostridiaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	hly	-	4.4.1.8	ko:K00842,ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_2218166_6	1469948.JPNB01000002_gene3068	3.499e-47	177.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,36DKQ@31979|Clostridiaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	hly	-	4.4.1.8	ko:K00842,ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_2220136_19	158189.SpiBuddy_2121	4.135e-49	175.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS1_k127_2220136_10	158190.SpiGrapes_2693	2.469e-136	445.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	yxlH	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS1_k127_2220136_9	158190.SpiGrapes_2694	1.197e-142	458.0	COG0384@1|root,COG0384@2|Bacteria,2J8KF@203691|Spirochaetes	203691|Spirochaetes	S	Phenazine biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
CMS1_k127_2220136_6	158190.SpiGrapes_2696	4.503e-204	638.0	COG0820@1|root,COG0820@2|Bacteria,2J5C3@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
CMS1_k127_2220136_1	158190.SpiGrapes_2697	1.81e-290	899.0	COG1297@1|root,COG1297@2|Bacteria,2J6XB@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Oligopeptide transporter OPT superfamily	-	-	-	-	-	-	-	-	-	-	-	-	OPT
CMS1_k127_2220136_11	158190.SpiGrapes_0224	1.343e-130	426.0	COG0535@1|root,COG0535@2|Bacteria,2J83E@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS1_k127_2220136_3	158190.SpiGrapes_2699	2.799e-253	785.0	COG2262@1|root,COG2262@2|Bacteria,2J5R1@203691|Spirochaetes	203691|Spirochaetes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CMS1_k127_2220136_5	158190.SpiGrapes_2700	1.262e-222	693.0	COG0012@1|root,COG0012@2|Bacteria,2J5RK@203691|Spirochaetes	203691|Spirochaetes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS1_k127_2220136_2	158190.SpiGrapes_2702	3.474e-285	885.0	COG1032@1|root,COG1032@2|Bacteria,2J66V@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
CMS1_k127_2220136_0	158190.SpiGrapes_2704	0.0	1524.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2J5BS@203691|Spirochaetes	203691|Spirochaetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
CMS1_k127_2220136_13	158190.SpiGrapes_2707	6.95e-108	353.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_2220136_15	158190.SpiGrapes_2708	5.991e-69	235.0	COG3255@1|root,COG3255@2|Bacteria	2|Bacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
CMS1_k127_2220136_4	158190.SpiGrapes_2709	6.247e-246	761.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
CMS1_k127_2220136_8	158190.SpiGrapes_2710	1.465e-153	492.0	COG1035@1|root,COG1143@1|root,COG1035@2|Bacteria,COG1143@2|Bacteria,2J817@203691|Spirochaetes	203691|Spirochaetes	C	Coenzyme F420 hydrogenase dehydrogenase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N
CMS1_k127_2220136_16	158190.SpiGrapes_2713	4.394e-68	239.0	COG0262@1|root,COG0262@2|Bacteria	2|Bacteria	H	dihydrofolate reductase activity	FolA	-	-	-	-	-	-	-	-	-	-	-	RibD_C
CMS1_k127_2220136_20	1190606.AJYG01000007_gene2431	7.115e-49	181.0	COG1280@1|root,COG1280@2|Bacteria,1R7UJ@1224|Proteobacteria,1RYYM@1236|Gammaproteobacteria,1Y2Y3@135623|Vibrionales	135623|Vibrionales	E	threonine efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS1_k127_2220136_18	158189.SpiBuddy_2037	4.608e-54	196.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
CMS1_k127_2227676_17	1408422.JHYF01000016_gene120	4.388e-43	162.0	COG0221@1|root,COG3871@1|root,COG0221@2|Bacteria,COG3871@2|Bacteria,1VB6Q@1239|Firmicutes,24NZI@186801|Clostridia,36JZ4@31979|Clostridiaceae	186801|Clostridia	C	Inorganic pyrophosphatase	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	NUDIX,Pyrophosphatase
CMS1_k127_2227676_5	768706.Desor_2509	1.266e-149	477.0	COG0491@1|root,COG0491@2|Bacteria,1TX4N@1239|Firmicutes,24A0N@186801|Clostridia,263MN@186807|Peptococcaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_2227676_4	158189.SpiBuddy_1219	3.375e-199	631.0	COG1593@1|root,COG1593@2|Bacteria,2J6K2@203691|Spirochaetes	203691|Spirochaetes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS1_k127_2227676_12	158189.SpiBuddy_1220	7.329e-83	280.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689,ko:K21394	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
CMS1_k127_2227676_6	158189.SpiBuddy_1221	6.467e-146	469.0	COG1638@1|root,COG1638@2|Bacteria,2J5GS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
CMS1_k127_2227676_7	861454.HMPREF9099_01170	5.858e-109	357.0	COG1878@1|root,COG1878@2|Bacteria,1V34U@1239|Firmicutes,248XJ@186801|Clostridia,27QC7@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
CMS1_k127_2227676_10	457421.CBFG_02127	2.958e-84	289.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,249J4@186801|Clostridia	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
CMS1_k127_2227676_18	500635.MITSMUL_04289	5.43e-26	113.0	COG2731@1|root,COG2731@2|Bacteria,1V510@1239|Firmicutes,4H98A@909932|Negativicutes	909932|Negativicutes	G	Domain of unknown function (DUF386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF386
CMS1_k127_2227676_8	1235792.C808_03805	1.207e-91	311.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,27I9S@186928|unclassified Lachnospiraceae	186801|Clostridia	K	helix_turn _helix lactose operon repressor	ccpA	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_2227676_9	393480.FNP_1264	3.46e-86	301.0	COG1619@1|root,COG1619@2|Bacteria,379TJ@32066|Fusobacteria	32066|Fusobacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S66
CMS1_k127_2227676_0	573413.Spirs_3268	0.0	1010.0	COG1132@1|root,COG1132@2|Bacteria,2J5W8@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K11085,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS1_k127_2227676_1	573413.Spirs_3269	7.236e-294	910.0	COG1132@1|root,COG1132@2|Bacteria,2J676@203691|Spirochaetes	203691|Spirochaetes	V	COGs COG1132 ABC-type multidrug transport system ATPase and permease components	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS1_k127_2227676_15	573413.Spirs_3270	5.045e-52	187.0	COG1846@1|root,COG1846@2|Bacteria,2JATC@203691|Spirochaetes	203691|Spirochaetes	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CMS1_k127_2227676_11	536227.CcarbDRAFT_0124	5.126e-83	279.0	COG0693@1|root,COG0693@2|Bacteria,1V1TX@1239|Firmicutes,25CHM@186801|Clostridia,36WW9@31979|Clostridiaceae	186801|Clostridia	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
CMS1_k127_2227676_16	1122925.KB895376_gene460	6.859e-46	175.0	COG1309@1|root,COG1309@2|Bacteria,1V1C8@1239|Firmicutes,4HJ6G@91061|Bacilli,270VF@186822|Paenibacillaceae	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
CMS1_k127_2227676_2	994573.T472_0210175	2.441e-234	741.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.31	ko:K10797	ko00360,ko01120,map00360,map01120	-	R02252	RC00669	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
CMS1_k127_2227676_13	158190.SpiGrapes_2309	9.043e-66	227.0	COG1762@1|root,COG1762@2|Bacteria,2J5KE@203691|Spirochaetes	203691|Spirochaetes	G	DNA-binding protein PTS system, IIA component	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
CMS1_k127_2227676_3	158190.SpiGrapes_2308	4.298e-206	646.0	COG0475@1|root,COG0475@2|Bacteria,2J5WC@203691|Spirochaetes	203691|Spirochaetes	P	Sodium hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Na_H_Exchanger
CMS1_k127_2227676_14	158190.SpiGrapes_2307	1.567e-54	192.0	29AXJ@1|root,2ZXWN@2|Bacteria,2JBAS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2227676_19	552398.HMPREF0866_00471	5.105e-15	81.0	COG1321@1|root,COG1321@2|Bacteria,1V3IS@1239|Firmicutes,24MSE@186801|Clostridia,3WK31@541000|Ruminococcaceae	186801|Clostridia	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
CMS1_k127_2227676_20	1121354.AQUV01000002_gene632	2.012e-06	55.0	COG1846@1|root,COG1846@2|Bacteria,2IP3B@201174|Actinobacteria,22REJ@1653|Corynebacteriaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS1_k127_2245002_9	33035.JPJF01000040_gene5183	9.967e-35	136.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,24AE3@186801|Clostridia,3Y1MA@572511|Blautia	186801|Clostridia	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
CMS1_k127_2245002_5	158190.SpiGrapes_2212	1.137e-114	372.0	COG1149@1|root,COG1149@2|Bacteria,2JBH1@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S dicluster domain	fdx	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS1_k127_2245002_7	158190.SpiGrapes_2211	2.513e-92	308.0	COG0664@1|root,COG0664@2|Bacteria,2J74U@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, Crp Fnr family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_2245002_2	158190.SpiGrapes_2209	2.312e-173	547.0	COG4638@1|root,COG4638@2|Bacteria,2J9Z7@203691|Spirochaetes	203691|Spirochaetes	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
CMS1_k127_2245002_4	158190.SpiGrapes_2207	5.332e-154	491.0	COG0428@1|root,COG0428@2|Bacteria,2J6TD@203691|Spirochaetes	203691|Spirochaetes	P	PFAM zinc iron permease	zupT	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
CMS1_k127_2245002_1	158190.SpiGrapes_2206	3.296e-222	693.0	COG1295@1|root,COG1378@1|root,COG1295@2|Bacteria,COG1378@2|Bacteria,2JAZX@203691|Spirochaetes	203691|Spirochaetes	K	TIGRFAM YihY family protein (not ribonuclease BN)	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS1_k127_2245002_3	158190.SpiGrapes_2205	7.147e-169	533.0	COG2267@1|root,COG2267@2|Bacteria,2J6F5@203691|Spirochaetes	203691|Spirochaetes	I	Alpha beta	pldB	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS1_k127_2245002_10	760011.Spico_1225	8.787e-30	126.0	COG0622@1|root,COG0622@2|Bacteria	2|Bacteria	S	retrograde transport, endosome to Golgi	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
CMS1_k127_2245002_0	158190.SpiGrapes_2201	4.673e-256	801.0	COG2414@1|root,COG2414@2|Bacteria	2|Bacteria	C	aldehyde ferredoxin oxidoreductase activity	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS1_k127_2245002_6	158190.SpiGrapes_2200	2.356e-109	357.0	COG0441@1|root,COG0572@1|root,COG0441@2|Bacteria,COG0572@2|Bacteria,2J578@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribulokinase Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
CMS1_k127_2316763_0	158190.SpiGrapes_3227	9.867e-210	660.0	COG0773@1|root,COG0773@2|Bacteria,2J5DC@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS1_k127_2316763_3	158190.SpiGrapes_3226	1.677e-25	106.0	2EMZY@1|root,33FN4@2|Bacteria,2J8Y2@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2316763_1	158190.SpiGrapes_3221	3.245e-156	496.0	COG3649@1|root,COG3649@2|Bacteria,2J5EI@203691|Spirochaetes	203691|Spirochaetes	L	TIGRFAM CRISPR-associated protein, CT1132 family	-	-	-	ko:K19118	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas7
CMS1_k127_2316763_2	158190.SpiGrapes_3220	1.426e-109	361.0	28HN3@1|root,2Z7WH@2|Bacteria,2J5Z8@203691|Spirochaetes	203691|Spirochaetes	S	CRISPR-associated protein, Csd1 family	-	-	-	ko:K19117	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Csd1
CMS1_k127_2317767_15	158190.SpiGrapes_1607	8.5e-47	171.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K15773	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,HTH_31
CMS1_k127_2317767_16	158190.SpiGrapes_1609	1.712e-39	148.0	2DNUA@1|root,32Z63@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2317767_17	443143.GM18_3957	8.968e-12	73.0	COG3118@1|root,COG3118@2|Bacteria,1Q210@1224|Proteobacteria,42NY3@68525|delta/epsilon subdivisions,2WK55@28221|Deltaproteobacteria,43TBE@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Type II secretory pathway component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2317767_3	158189.SpiBuddy_2626	1.351e-99	332.0	COG2253@1|root,COG2253@2|Bacteria	2|Bacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS1_k127_2317767_7	158189.SpiBuddy_2625	2.053e-66	233.0	COG5340@1|root,COG5340@2|Bacteria,2J94C@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2317767_0	658086.HMPREF0994_03514	0.0	1204.0	COG0457@1|root,COG0457@2|Bacteria,1TPP8@1239|Firmicutes,24DJT@186801|Clostridia,27N7A@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Domain of unknown function (DUF5107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5107,TPR_16,TPR_8
CMS1_k127_2317767_9	610130.Closa_0082	3.117e-61	221.0	COG2207@1|root,COG2207@2|Bacteria,1UYBE@1239|Firmicutes,24FAY@186801|Clostridia,21YXI@1506553|Lachnoclostridium	186801|Clostridia	K	AraC-binding-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
CMS1_k127_2317767_13	1077285.AGDG01000020_gene969	1.993e-51	195.0	COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,4PKXD@976|Bacteroidetes,2G07Q@200643|Bacteroidia,4AV30@815|Bacteroidaceae	976|Bacteroidetes	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_AraC
CMS1_k127_2317767_11	446469.Sked_11600	9.261e-56	212.0	COG2182@1|root,COG2182@2|Bacteria,2I4X5@201174|Actinobacteria	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
CMS1_k127_2317767_6	358823.DF19_40815	1.519e-67	239.0	COG1175@1|root,COG1175@2|Bacteria,2I8RC@201174|Actinobacteria	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10189	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	BPD_transp_1
CMS1_k127_2317767_10	397278.JOJN01000004_gene1530	1.185e-59	218.0	COG0395@1|root,COG0395@2|Bacteria,2GMTH@201174|Actinobacteria,4DU5W@85009|Propionibacteriales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
CMS1_k127_2317767_1	926550.CLDAP_19940	4.199e-283	900.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS1_k127_2317767_4	696281.Desru_3134	1.106e-95	326.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,263FM@186807|Peptococcaceae	186801|Clostridia	E	Zinc-binding dehydrogenase	ydjJ	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_2317767_2	158190.SpiGrapes_1606	1.212e-222	693.0	COG3177@1|root,COG3177@2|Bacteria,2J7GE@203691|Spirochaetes	203691|Spirochaetes	S	Fic DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
CMS1_k127_2317767_18	158189.SpiBuddy_0327	0.0006968	44.0	COG2253@1|root,COG2253@2|Bacteria,2J5IH@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS1_k127_2317767_12	158189.SpiBuddy_0497	4.178e-55	202.0	COG4130@1|root,COG4130@2|Bacteria,2J8DR@203691|Spirochaetes	203691|Spirochaetes	G	Xylose isomerase domain protein TIM barrel	-	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
CMS1_k127_2317767_5	526222.Desal_0339	1.509e-81	282.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS1_k127_2317767_8	158189.SpiBuddy_2633	1.39e-64	230.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,2J7WG@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
CMS1_k127_2317767_14	158189.SpiBuddy_2634	2.828e-51	193.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
CMS1_k127_2318556_4	1125699.HMPREF9194_00902	3.053e-42	160.0	COG1653@1|root,COG1653@2|Bacteria,2JAFM@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
CMS1_k127_2318556_2	1125699.HMPREF9194_00903	4.072e-91	308.0	COG0395@1|root,COG0395@2|Bacteria,2JAF4@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
CMS1_k127_2318556_1	1125699.HMPREF9194_00904	3.956e-101	337.0	COG4209@1|root,COG4209@2|Bacteria,2JA83@203691|Spirochaetes	203691|Spirochaetes	G	transmembrane transport	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
CMS1_k127_2318556_0	1121094.KB894649_gene1287	3.521e-173	557.0	COG3408@1|root,COG3408@2|Bacteria,4NI03@976|Bacteroidetes,2FQYR@200643|Bacteroidia,4AMVT@815|Bacteroidaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
CMS1_k127_2318556_3	1125699.HMPREF9194_00905	3.703e-60	217.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
CMS1_k127_232375_22	158190.SpiGrapes_1193	8.625e-142	454.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes	203691|Spirochaetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
CMS1_k127_232375_23	158190.SpiGrapes_1194	3.531e-137	440.0	COG1235@1|root,COG1235@2|Bacteria,2J7C5@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I	phnP	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
CMS1_k127_232375_3	158190.SpiGrapes_1198	0.0	1081.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2J65C@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
CMS1_k127_232375_25	158189.SpiBuddy_0809	1.344e-128	425.0	COG2265@1|root,COG2265@2|Bacteria,2J5Y7@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	ygcA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
CMS1_k127_232375_5	158190.SpiGrapes_1200	5.985e-311	960.0	COG1164@1|root,COG1164@2|Bacteria,2J5QP@203691|Spirochaetes	203691|Spirochaetes	E	Oligoendopeptidase, pepF M3 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3,Peptidase_M3_N
CMS1_k127_232375_6	158190.SpiGrapes_1201	4.719e-267	825.0	COG2204@1|root,COG2204@2|Bacteria,2J6EQ@203691|Spirochaetes	203691|Spirochaetes	T	response regulator	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS1_k127_232375_7	158190.SpiGrapes_1202	4.894e-240	746.0	COG4191@1|root,COG4191@2|Bacteria,2J87U@203691|Spirochaetes	203691|Spirochaetes	T	Signal transduction histidine kinase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
CMS1_k127_232375_11	158190.SpiGrapes_1203	4.067e-205	644.0	COG0577@1|root,COG0577@2|Bacteria,2J66A@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS1_k127_232375_26	158190.SpiGrapes_1204	2.291e-128	411.0	COG1136@1|root,COG1136@2|Bacteria,2J6R3@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_232375_13	158190.SpiGrapes_1205	1.344e-187	591.0	COG0845@1|root,COG0845@2|Bacteria,2J6C6@203691|Spirochaetes	203691|Spirochaetes	M	Efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS1_k127_232375_30	158190.SpiGrapes_1207	4.027e-107	351.0	COG1028@1|root,COG1028@2|Bacteria,2JAPN@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100,1.5.1.33	ko:K00059,ko:K03793	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS1_k127_232375_1	158190.SpiGrapes_1208	0.0	1161.0	COG0465@1|root,COG0465@2|Bacteria,2J58Y@203691|Spirochaetes	203691|Spirochaetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS1_k127_232375_16	158190.SpiGrapes_1209	2.013e-169	535.0	COG1281@1|root,COG1281@2|Bacteria,2J58S@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG1281 Disulfide bond chaperones of the HSP33 family	-	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
CMS1_k127_232375_0	158190.SpiGrapes_1210	0.0	1430.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,2J5I4@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.191,2.1.1.264	ko:K06969,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
CMS1_k127_232375_29	158190.SpiGrapes_1211	4.686e-115	378.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	-	-	2.1.1.144,2.1.1.197	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
CMS1_k127_232375_12	158190.SpiGrapes_1213	1.46e-193	607.0	COG1052@1|root,COG1052@2|Bacteria,2J6XR@203691|Spirochaetes	203691|Spirochaetes	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS1_k127_232375_21	158190.SpiGrapes_1215	4.785e-145	462.0	COG2184@1|root,COG2184@2|Bacteria	2|Bacteria	D	nucleotidyltransferase activity	fic	GO:0008150,GO:0050789,GO:0050794,GO:0051302,GO:0065007	-	ko:K04095	-	-	-	-	ko00000,ko03036	-	-	-	Fic
CMS1_k127_232375_31	158190.SpiGrapes_1217	2.686e-88	296.0	COG1611@1|root,COG1611@2|Bacteria,2JAES@203691|Spirochaetes	203691|Spirochaetes	S	Cytokinin riboside 5'-monophosphate phosphoribohydrolase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS1_k127_232375_17	158190.SpiGrapes_1218	1.403e-167	530.0	COG1284@1|root,COG1284@2|Bacteria,2J8P0@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterised 5xTM membrane BCR, YitT family COG1284	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
CMS1_k127_232375_15	158190.SpiGrapes_1219	1.186e-170	543.0	COG1208@1|root,COG1208@2|Bacteria,2J69H@203691|Spirochaetes	203691|Spirochaetes	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
CMS1_k127_232375_4	158190.SpiGrapes_1223	0.0	1029.0	COG1472@1|root,COG1472@2|Bacteria,2J60D@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CMS1_k127_232375_20	158190.SpiGrapes_1224	7.837e-152	486.0	COG1692@1|root,COG1692@2|Bacteria,2J6ZK@203691|Spirochaetes	203691|Spirochaetes	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
CMS1_k127_232375_35	158190.SpiGrapes_1225	2.45e-64	225.0	COG3086@1|root,COG3086@2|Bacteria	2|Bacteria	T	response to oxidative stress	rseC	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
CMS1_k127_232375_34	158190.SpiGrapes_1226	7.869e-66	230.0	28XQQ@1|root,2ZJMD@2|Bacteria,2J8Q3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LptC
CMS1_k127_232375_24	158190.SpiGrapes_1228	9.339e-136	435.0	COG1137@1|root,COG1137@2|Bacteria,2J5CM@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
CMS1_k127_232375_8	158190.SpiGrapes_1229	1.153e-234	733.0	COG1508@1|root,COG1508@2|Bacteria,2J5KV@203691|Spirochaetes	203691|Spirochaetes	K	RNA polymerase sigma54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
CMS1_k127_232375_37	158190.SpiGrapes_1230	9.065e-53	189.0	COG1544@1|root,COG1544@2|Bacteria	2|Bacteria	J	regulation of translation	raiA	-	-	ko:K03733,ko:K05808,ko:K05809	-	-	-	-	ko00000,ko03009,ko03036	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
CMS1_k127_232375_10	158190.SpiGrapes_1231	2.251e-206	643.0	COG1493@1|root,COG1493@2|Bacteria,2J5JA@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
CMS1_k127_232375_38	158190.SpiGrapes_1232	5.326e-45	164.0	COG1925@1|root,COG1925@2|Bacteria,2J8AV@203691|Spirochaetes	203691|Spirochaetes	G	phosphocarrier protein HPr	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
CMS1_k127_232375_27	158190.SpiGrapes_1233	7.505e-120	386.0	COG1974@1|root,COG1974@2|Bacteria,2J7ID@203691|Spirochaetes	203691|Spirochaetes	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
CMS1_k127_232375_14	158190.SpiGrapes_1234	8.503e-187	589.0	COG1466@1|root,COG1466@2|Bacteria,2J6PN@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
CMS1_k127_232375_2	158190.SpiGrapes_1235	0.0	1094.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CMS1_k127_232375_9	158190.SpiGrapes_1236	7.188e-218	681.0	COG1533@1|root,COG1533@2|Bacteria,2J9M1@203691|Spirochaetes	203691|Spirochaetes	L	DNA photolyase activity	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS1_k127_232375_19	158190.SpiGrapes_1237	1.708e-162	513.0	COG0508@1|root,COG0508@2|Bacteria,2J5U3@203691|Spirochaetes	203691|Spirochaetes	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
CMS1_k127_2334524_0	158190.SpiGrapes_0238	0.0	1178.0	COG1609@1|root,COG4585@1|root,COG1609@2|Bacteria,COG4585@2|Bacteria,2J7X5@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Peripla_BP_3
CMS1_k127_2334524_1	1480694.DC28_13710	5.688e-11	68.0	COG2197@1|root,COG2197@2|Bacteria,2JA92@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS1_k127_2340077_4	158189.SpiBuddy_0686	0.0005102	43.0	COG3459@1|root,COG3459@2|Bacteria,2J5T5@203691|Spirochaetes	203691|Spirochaetes	G	Cellobiose phosphorylase	-	-	2.4.1.20,2.4.1.280	ko:K00702,ko:K18675	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00952,R09942	RC00049	ko00000,ko00001,ko01000	-	GH94,GT36	-	Glyco_hydro_36,Glyco_transf_36
CMS1_k127_2340077_1	1125725.HMPREF1325_2362	1.553e-188	594.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS1_k127_2340077_2	1125725.HMPREF1325_2363	1.754e-128	415.0	COG0395@1|root,COG0395@2|Bacteria,2JBHA@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2340077_3	1125725.HMPREF1325_2364	5.701e-123	402.0	COG1175@1|root,COG1175@2|Bacteria,2J5EA@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1175 ABC-type sugar transport systems permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2340077_0	1125725.HMPREF1325_2365	8.135e-212	664.0	COG1653@1|root,COG1653@2|Bacteria,2JAWJ@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
CMS1_k127_2375844_4	158190.SpiGrapes_1728	3.432e-48	173.0	299ND@1|root,2ZWQQ@2|Bacteria,2J8VN@203691|Spirochaetes	203691|Spirochaetes	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
CMS1_k127_2375844_0	158190.SpiGrapes_1727	1.468e-292	906.0	COG2376@1|root,COG2376@2|Bacteria,2J735@203691|Spirochaetes	203691|Spirochaetes	G	Dihydroxyacetone kinase	dhaK	-	2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Dak1
CMS1_k127_2375844_1	158190.SpiGrapes_1726	5.85e-220	687.0	COG3681@1|root,COG3681@2|Bacteria,2J6AS@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0597 family	-	-	-	-	-	-	-	-	-	-	-	-	SDH_alpha
CMS1_k127_2375844_2	1095769.CAHF01000011_gene2568	2.525e-177	582.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS,PAS_3
CMS1_k127_2375844_5	158189.SpiBuddy_2032	7.337e-19	87.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	hipB	-	-	ko:K15773	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,HTH_31
CMS1_k127_2375844_6	158190.SpiGrapes_1723	0.0006651	42.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	hipB	-	-	ko:K15773	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,HTH_31
CMS1_k127_2375844_3	158190.SpiGrapes_1684	1.495e-57	202.0	COG0778@1|root,COG0778@2|Bacteria,2J8K9@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS1_k127_2376244_0	158190.SpiGrapes_0446	8.927e-151	478.0	COG0358@1|root,COG0358@2|Bacteria,2J5MX@203691|Spirochaetes	203691|Spirochaetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
CMS1_k127_2376244_1	158190.SpiGrapes_0447	3.518e-82	278.0	COG0727@1|root,COG0727@2|Bacteria,2J85V@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS1_k127_2428746_0	457421.CBFG_04444	2.104e-164	529.0	COG1653@1|root,COG1653@2|Bacteria,1VRMR@1239|Firmicutes	1239|Firmicutes	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
CMS1_k127_2428746_2	935840.JAEQ01000016_gene2154	1.03e-83	287.0	COG0407@1|root,COG0407@2|Bacteria,1NDUE@1224|Proteobacteria	1224|Proteobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS1_k127_2428746_1	158190.SpiGrapes_0147	1.358e-134	442.0	COG3681@1|root,COG3681@2|Bacteria,2J6AS@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0597 family	-	-	-	-	-	-	-	-	-	-	-	-	SDH_alpha
CMS1_k127_2429620_22	158190.SpiGrapes_2360	2.832e-112	363.0	COG1175@1|root,COG1175@2|Bacteria,2J6XG@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10228	ko02010,map02010	M00200,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.5	-	-	BPD_transp_1
CMS1_k127_2429620_12	158190.SpiGrapes_2361	1.429e-161	516.0	COG0395@1|root,COG0395@2|Bacteria,2J6HM@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10229	ko02010,map02010	M00200,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.5	-	-	BPD_transp_1
CMS1_k127_2429620_6	158190.SpiGrapes_2362	4.521e-228	717.0	COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_2429620_10	158190.SpiGrapes_2363	1.009e-188	592.0	COG1063@1|root,COG1063@2|Bacteria,2J5R7@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Alcohol dehydrogenase GroES-like	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_2429620_15	158190.SpiGrapes_2364	7.011e-146	465.0	COG1028@1|root,COG1028@2|Bacteria,2J9K9@203691|Spirochaetes	203691|Spirochaetes	C	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
CMS1_k127_2429620_9	158190.SpiGrapes_2365	4.354e-189	594.0	COG1063@1|root,COG1063@2|Bacteria,2J6GV@203691|Spirochaetes	203691|Spirochaetes	C	Zinc-binding dehydrogenase	-	-	1.1.1.14,1.1.1.9	ko:K00008,ko:K05351	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_2429620_13	158190.SpiGrapes_1333	4.155e-152	484.0	COG0834@1|root,COG0834@2|Bacteria,2J6M7@203691|Spirochaetes	203691|Spirochaetes	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030,ko:K17073	ko02010,map02010	M00236,M00589	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.20	-	-	SBP_bac_3
CMS1_k127_2429620_14	158190.SpiGrapes_1332	1.617e-150	478.0	COG0765@1|root,COG0765@2|Bacteria,2JAEE@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K17074	ko02010,map02010	M00589	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.20	-	-	BPD_transp_1
CMS1_k127_2429620_16	158190.SpiGrapes_1331	6.246e-139	443.0	COG1126@1|root,COG1126@2|Bacteria,2JBGY@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type polar amino acid transport system ATPase component	-	-	-	ko:K16960,ko:K17076	ko02010,map02010	M00585,M00589	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.13,3.A.1.3.20	-	-	ABC_tran
CMS1_k127_2429620_27	158190.SpiGrapes_1339	6.181e-75	259.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183,ko:K21600	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25,Methyltransf_31
CMS1_k127_2429620_30	357809.Cphy_1565	1.44e-40	154.0	COG0375@1|root,COG0375@2|Bacteria,1V8EK@1239|Firmicutes,25CVT@186801|Clostridia	186801|Clostridia	S	Hydrogenase nickel insertion protein HypA	-	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
CMS1_k127_2429620_0	158190.SpiGrapes_1337	0.0	1557.0	COG0493@1|root,COG1145@1|root,COG1149@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,COG1149@2|Bacteria,2J5W1@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
CMS1_k127_2429620_20	158190.SpiGrapes_1336	1.777e-114	372.0	COG0378@1|root,COG0378@2|Bacteria,2J65E@203691|Spirochaetes	203691|Spirochaetes	KO	Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
CMS1_k127_2429620_11	158190.SpiGrapes_1335	1.874e-185	583.0	28H6R@1|root,2Z7J3@2|Bacteria,2J5BX@203691|Spirochaetes	203691|Spirochaetes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2429620_19	158190.SpiGrapes_1334	7.594e-120	389.0	COG2186@1|root,COG2186@2|Bacteria,2J8F7@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, GntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,FadR_C,GntR
CMS1_k127_2429620_5	158190.SpiGrapes_1330	1.337e-266	822.0	COG0104@1|root,COG0104@2|Bacteria,2J6B6@203691|Spirochaetes	203691|Spirochaetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
CMS1_k127_2429620_23	158190.SpiGrapes_1329	1.252e-111	362.0	COG2236@1|root,COG2236@2|Bacteria,2JAE0@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
CMS1_k127_2429620_21	158190.SpiGrapes_1328	3.88e-113	365.0	COG0634@1|root,COG0634@2|Bacteria,2J8PE@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CMS1_k127_2429620_25	158190.SpiGrapes_1327	5.476e-93	309.0	COG1853@1|root,COG1853@2|Bacteria,2J8D2@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1853 Conserved protein domain typically associated with flavoprotein oxygenase DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CMS1_k127_2429620_1	158190.SpiGrapes_1326	0.0	1118.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2JA17@203691|Spirochaetes	203691|Spirochaetes	C	Dehydrogenase E1 component	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
CMS1_k127_2429620_4	158190.SpiGrapes_1325	3.261e-319	979.0	COG0016@1|root,COG0016@2|Bacteria,2J63H@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
CMS1_k127_2429620_2	158190.SpiGrapes_1324	0.0	1050.0	COG0072@1|root,COG0072@2|Bacteria,2J63Q@203691|Spirochaetes	203691|Spirochaetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B5,tRNA-synt_2d,tRNA_bind
CMS1_k127_2429620_33	158190.SpiGrapes_1317	1.076e-28	120.0	COG0329@1|root,COG0329@2|Bacteria,2J59X@203691|Spirochaetes	203691|Spirochaetes	H	Dihydrodipicolinate synthetase family	-	-	4.1.3.3	ko:K01639	ko00520,map00520	-	R01811	RC00159,RC00600	ko00000,ko00001,ko01000	-	-	-	DHDPS
CMS1_k127_2429620_7	158190.SpiGrapes_1314	4.835e-228	719.0	COG0651@1|root,COG0651@2|Bacteria,2J5CC@203691|Spirochaetes	203691|Spirochaetes	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
CMS1_k127_2429620_36	1499967.BAYZ01000028_gene1295	4.872e-21	96.0	COG1006@1|root,COG1006@2|Bacteria,2NQ57@2323|unclassified Bacteria	2|Bacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
CMS1_k127_2429620_24	158190.SpiGrapes_1312	2.26e-100	335.0	COG2111@1|root,COG2111@2|Bacteria,2J8MC@203691|Spirochaetes	203691|Spirochaetes	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MnhB
CMS1_k127_2429620_34	158190.SpiGrapes_1311	8.483e-27	111.0	COG1563@1|root,COG1563@2|Bacteria,2J8WX@203691|Spirochaetes	203691|Spirochaetes	P	Domain of unknown function (DUF4040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040
CMS1_k127_2429620_31	158190.SpiGrapes_1310	9.151e-34	138.0	COG1320@1|root,COG1320@2|Bacteria,2J97V@203691|Spirochaetes	203691|Spirochaetes	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
CMS1_k127_2429620_32	158190.SpiGrapes_1309	9.879e-33	129.0	COG2212@1|root,COG2212@2|Bacteria,2J93V@203691|Spirochaetes	203691|Spirochaetes	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
CMS1_k127_2429620_26	158190.SpiGrapes_1308	4.513e-80	269.0	COG1863@1|root,COG1863@2|Bacteria,2J884@203691|Spirochaetes	203691|Spirochaetes	P	Na+/H+ ion antiporter subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
CMS1_k127_2429620_28	158190.SpiGrapes_1307	4.624e-73	249.0	COG1762@1|root,COG1762@2|Bacteria,2J92G@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
CMS1_k127_2429620_29	158190.SpiGrapes_1306	3.443e-61	213.0	COG0347@1|root,COG0347@2|Bacteria,2J85W@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2429620_35	158190.SpiGrapes_1305	1.516e-22	103.0	COG3077@1|root,COG3077@2|Bacteria	2|Bacteria	L	bacterial-type proximal promoter sequence-specific DNA binding	relB	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
CMS1_k127_2429620_3	760011.Spico_1278	0.0	1037.0	2CC7E@1|root,2Z7WG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2429620_8	760011.Spico_1279	6.973e-201	633.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K17241	ko02010,map02010	M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.39	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2429620_17	760011.Spico_1280	4.669e-136	440.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10193,ko:K15771,ko:K17242	ko02010,map02010	M00196,M00198,M00202,M00207,M00491,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.11,3.A.1.1.16,3.A.1.1.2,3.A.1.1.28,3.A.1.1.3,3.A.1.1.39	-	-	BPD_transp_1
CMS1_k127_2429620_18	760011.Spico_1281	2.917e-131	425.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K17243	ko02010,map02010	M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.39	-	-	BPD_transp_1
CMS1_k127_2439390_0	1195236.CTER_4300	2.219e-134	439.0	COG0673@1|root,COG0673@2|Bacteria,1TRCC@1239|Firmicutes,248FQ@186801|Clostridia	186801|Clostridia	S	Oxidoreductase NAD-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_2439390_2	1347086.CCBA010000023_gene2167	9.011e-96	328.0	COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,4HBRS@91061|Bacilli,1ZEWW@1386|Bacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2439390_6	906968.Trebr_0044	7.573e-56	207.0	COG1175@1|root,COG1175@2|Bacteria,2J5Q4@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2439390_4	743719.PaelaDRAFT_5003	1.044e-82	282.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBKE@91061|Bacilli,26R31@186822|Paenibacillaceae	91061|Bacilli	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2439390_3	1123274.KB899413_gene796	1.379e-87	297.0	COG1830@1|root,COG1830@2|Bacteria,2J5HC@203691|Spirochaetes	203691|Spirochaetes	G	PFAM DeoC LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
CMS1_k127_2439390_1	744872.Spica_2681	1.174e-102	342.0	COG2253@1|root,COG2253@2|Bacteria,2J5IH@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS1_k127_2439390_5	158189.SpiBuddy_0214	5.458e-78	264.0	COG5340@1|root,COG5340@2|Bacteria,2J8AW@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_245047_0	1232443.BAIA02000124_gene1195	7.189e-113	376.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,2686E@186813|unclassified Clostridiales	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_245047_1	1286171.EAL2_c15500	5.11e-108	361.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia,25ZSH@186806|Eubacteriaceae	186801|Clostridia	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
CMS1_k127_245047_2	768706.Desor_4149	1.311e-58	212.0	COG0789@1|root,COG0789@2|Bacteria,1VTPX@1239|Firmicutes,24GCT@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
CMS1_k127_2480797_7	158190.SpiGrapes_2582	4.443e-33	131.0	COG1879@1|root,COG1879@2|Bacteria,2J7XC@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM rhamnose ABC transporter, rhamnose-binding	-	-	-	ko:K10559	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	Peripla_BP_4
CMS1_k127_2480797_4	158190.SpiGrapes_2581	1.768e-154	495.0	COG3347@1|root,COG3347@2|Bacteria,2J7D3@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Class II aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
CMS1_k127_2480797_2	158190.SpiGrapes_2580	6.304e-245	759.0	COG4806@1|root,COG4806@2|Bacteria,2J6VW@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the rhamnose isomerase family	rhaA	-	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
CMS1_k127_2480797_5	158190.SpiGrapes_2579	6.304e-120	391.0	COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,2J7G6@203691|Spirochaetes	203691|Spirochaetes	K	SMART Helix-turn-helix, AraC type, DNA binding domain	-	-	-	ko:K02854,ko:K02855	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18
CMS1_k127_2480797_6	158190.SpiGrapes_2578	2.283e-77	260.0	COG4154@1|root,COG4154@2|Bacteria,2J8CF@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the RbsD FucU family	-	-	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
CMS1_k127_2480797_0	158190.SpiGrapes_2577	0.0	1208.0	COG2407@1|root,COG2407@2|Bacteria,2J685@203691|Spirochaetes	203691|Spirochaetes	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	fucI	-	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	-	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
CMS1_k127_2480797_3	158190.SpiGrapes_2576	5.033e-163	518.0	COG2055@1|root,COG2055@2|Bacteria,2JAQP@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.130	ko:K08092	ko00040,ko00053,map00040,map00053	-	R02637,R02639	RC00238	ko00000,ko00001,ko01000	-	-	-	Ldh_2
CMS1_k127_2480797_1	158190.SpiGrapes_2574	0.0	1057.0	COG1074@1|root,COG1074@2|Bacteria,2J5IQ@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the helicase family. UvrD subfamily	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
CMS1_k127_2500695_0	158190.SpiGrapes_0145	0.0	1270.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS1_k127_2500695_1	158190.SpiGrapes_0154	7.262e-42	158.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS1_k127_2518001_28	517418.Ctha_1019	1.015e-60	219.0	28PMV@1|root,2ZCAQ@2|Bacteria	2|Bacteria	S	COG NOG23385 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2518001_17	391623.TERMP_01961	2.559e-132	440.0	COG1757@1|root,arCOG02009@2157|Archaea,2XTG4@28890|Euryarchaeota,2437N@183968|Thermococci	183968|Thermococci	C	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
CMS1_k127_2518001_23	1458462.JNLK01000001_gene101	1.145e-74	259.0	COG0300@1|root,COG0300@2|Bacteria,1UHN7@1239|Firmicutes,25C2D@186801|Clostridia,27U2D@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS1_k127_2518001_27	158190.SpiGrapes_2719	1.748e-61	214.0	COG1970@1|root,COG1970@2|Bacteria,2J7XF@203691|Spirochaetes	203691|Spirochaetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
CMS1_k127_2518001_0	1120998.AUFC01000014_gene1655	9.07e-316	978.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
CMS1_k127_2518001_2	158189.SpiBuddy_2562	1.786e-294	908.0	COG2233@1|root,COG2233@2|Bacteria	2|Bacteria	F	PERMEase	Z012_07875	-	-	ko:K02824,ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40,2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
CMS1_k127_2518001_30	180332.JTGN01000003_gene1915	4.078e-35	135.0	2FHT2@1|root,349KC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2518001_4	1232453.BAIF02000040_gene3441	1.901e-278	865.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,26AE2@186813|unclassified Clostridiales	186801|Clostridia	F	Adenine deaminase C-terminal domain	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
CMS1_k127_2518001_8	158190.SpiGrapes_2720	2.071e-230	717.0	COG0683@1|root,COG0683@2|Bacteria,2J62Q@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS1_k127_2518001_11	158190.SpiGrapes_2721	3.007e-177	559.0	COG0559@1|root,COG0559@2|Bacteria,2J64W@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS1_k127_2518001_12	158190.SpiGrapes_2722	3.632e-173	547.0	COG4177@1|root,COG4177@2|Bacteria,2J7RK@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS1_k127_2518001_13	158190.SpiGrapes_2723	4.955e-158	499.0	COG0411@1|root,COG0411@2|Bacteria,2J9W2@203691|Spirochaetes	203691|Spirochaetes	E	branched-chain amino acid	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
CMS1_k127_2518001_15	158190.SpiGrapes_2724	1.381e-140	449.0	COG0410@1|root,COG0410@2|Bacteria,2JA42@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
CMS1_k127_2518001_20	158190.SpiGrapes_2725	7.15e-125	401.0	COG0517@1|root,COG0517@2|Bacteria,2J6JU@203691|Spirochaetes	203691|Spirochaetes	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
CMS1_k127_2518001_16	158190.SpiGrapes_2726	1.102e-138	447.0	COG2840@1|root,COG2840@2|Bacteria,2J57A@203691|Spirochaetes	203691|Spirochaetes	S	Smr domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Smr
CMS1_k127_2518001_29	760011.Spico_1083	4.583e-40	149.0	COG0361@1|root,COG0361@2|Bacteria,2J8JW@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
CMS1_k127_2518001_6	158190.SpiGrapes_2728	1.458e-260	807.0	COG0733@1|root,COG0733@2|Bacteria,2J6G9@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
CMS1_k127_2518001_1	158190.SpiGrapes_2729	1.705e-312	959.0	COG0112@1|root,COG0112@2|Bacteria,2J5XQ@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CMS1_k127_2518001_26	158190.SpiGrapes_2730	1.521e-61	214.0	COG0509@1|root,COG0509@2|Bacteria,2J8VK@203691|Spirochaetes	203691|Spirochaetes	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
CMS1_k127_2518001_7	158190.SpiGrapes_2731	2.468e-248	771.0	COG0403@1|root,COG0403@2|Bacteria,2J70G@203691|Spirochaetes	203691|Spirochaetes	C	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
CMS1_k127_2518001_3	158190.SpiGrapes_2732	1.095e-282	872.0	COG1003@1|root,COG1003@2|Bacteria,2J63E@203691|Spirochaetes	203691|Spirochaetes	E	Glycine dehydrogenase (aminomethyl-transferring)	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
CMS1_k127_2518001_5	158190.SpiGrapes_2733	3.79e-269	835.0	COG0044@1|root,COG0044@2|Bacteria,2J6KK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
CMS1_k127_2518001_10	158190.SpiGrapes_2734	1.517e-188	597.0	COG0295@1|root,COG0637@1|root,COG0295@2|Bacteria,COG0637@2|Bacteria,2J814@203691|Spirochaetes	203691|Spirochaetes	F	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	HAD_2,dCMP_cyt_deam_1
CMS1_k127_2518001_9	158190.SpiGrapes_2735	2.565e-190	604.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131,ko:K06132	ko00564,ko01100,map00564,map01100	-	R07390,R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
CMS1_k127_2518001_24	158190.SpiGrapes_2738	1.753e-71	244.0	COG0698@1|root,COG0698@2|Bacteria,2J8BN@203691|Spirochaetes	203691|Spirochaetes	G	Ribose 5-phosphate isomerase	rplB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
CMS1_k127_2518001_19	411902.CLOBOL_05502	3.748e-128	417.0	COG0407@1|root,COG0407@2|Bacteria,1TNYE@1239|Firmicutes,24DSS@186801|Clostridia,21ZT2@1506553|Lachnoclostridium	186801|Clostridia	H	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
CMS1_k127_2518001_18	411902.CLOBOL_01125	1.698e-131	426.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,21ZA3@1506553|Lachnoclostridium	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_2518001_21	411902.CLOBOL_01126	7.491e-116	380.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,21XVT@1506553|Lachnoclostridium	186801|Clostridia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS1_k127_2518001_14	411902.CLOBOL_01127	1.78e-157	513.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25KJ2@186801|Clostridia,21Y85@1506553|Lachnoclostridium	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
CMS1_k127_2520500_15	1120998.AUFC01000005_gene759	1.625e-76	279.0	COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,1TQ0S@1239|Firmicutes,24Y6H@186801|Clostridia,3WD8S@538999|Clostridiales incertae sedis	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,HD,HD_5,PAS,PAS_3,PAS_9,dCache_1
CMS1_k127_2520500_9	1111134.HMPREF1253_1956	1.391e-103	346.0	COG3842@1|root,COG3842@2|Bacteria,1TPW2@1239|Firmicutes,24DA6@186801|Clostridia,22IFV@1570339|Peptoniphilaceae	186801|Clostridia	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS1_k127_2520500_6	742733.HMPREF9469_02068	3.227e-116	383.0	COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,24B3A@186801|Clostridia,2216H@1506553|Lachnoclostridium	186801|Clostridia	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
CMS1_k127_2520500_2	742733.HMPREF9469_02067	4.096e-173	558.0	COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,24A64@186801|Clostridia,21YDA@1506553|Lachnoclostridium	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
CMS1_k127_2520500_18	938289.CAJN020000007_gene249	2.345e-49	188.0	COG1236@1|root,COG1236@2|Bacteria,1V90W@1239|Firmicutes,25125@186801|Clostridia	186801|Clostridia	J	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_2520500_17	1262914.BN533_01966	5.097e-55	199.0	COG0394@1|root,COG0394@2|Bacteria,1V6SG@1239|Firmicutes,4H4TE@909932|Negativicutes	909932|Negativicutes	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ptpA	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
CMS1_k127_2520500_19	158189.SpiBuddy_0898	3.799e-34	133.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	czrA	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
CMS1_k127_2520500_14	158190.SpiGrapes_1125	8.822e-78	265.0	COG5658@1|root,COG5658@2|Bacteria	2|Bacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
CMS1_k127_2520500_4	158190.SpiGrapes_1126	2.955e-161	522.0	COG1559@1|root,COG1559@2|Bacteria,2J5V4@203691|Spirochaetes	203691|Spirochaetes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
CMS1_k127_2520500_13	158190.SpiGrapes_1128	6.863e-86	288.0	COG0724@1|root,COG0724@2|Bacteria,2J7A1@203691|Spirochaetes	203691|Spirochaetes	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA
CMS1_k127_2520500_5	158190.SpiGrapes_1129	7.03e-122	392.0	COG0491@1|root,COG0491@2|Bacteria,2J8BJ@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG0491 Zn-dependent hydrolase including glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_2520500_1	158190.SpiGrapes_1130	1.112e-176	560.0	COG0019@1|root,COG0019@2|Bacteria,2J5K1@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS1_k127_2520500_16	158190.SpiGrapes_1131	8.523e-67	229.0	COG1734@1|root,COG1734@2|Bacteria,2J7Y1@203691|Spirochaetes	203691|Spirochaetes	T	Prokaryotic dksA traR C4-type zinc finger	dksA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
CMS1_k127_2520500_0	158190.SpiGrapes_1132	0.0	1479.0	COG0619@1|root,COG1122@1|root,COG0619@2|Bacteria,COG1122@2|Bacteria,2J5SA@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ,DUF3744
CMS1_k127_2520500_10	158190.SpiGrapes_1133	1.845e-103	338.0	COG4720@1|root,COG4720@2|Bacteria,2J802@203691|Spirochaetes	203691|Spirochaetes	S	ECF-type riboflavin transporter, S component	-	-	-	ko:K16924	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.29	-	-	ECF-ribofla_trS
CMS1_k127_2520500_3	158190.SpiGrapes_1134	1.061e-162	515.0	COG1912@1|root,COG1912@2|Bacteria,2J5EG@203691|Spirochaetes	203691|Spirochaetes	S	PFAM S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	SAM_adeno_trans
CMS1_k127_2520500_7	158190.SpiGrapes_1136	3.362e-115	372.0	COG0560@1|root,COG0560@2|Bacteria,2J5Q7@203691|Spirochaetes	203691|Spirochaetes	E	phosphoserine phosphatase homoserine phosphotransferase bifunctional protein	thrH	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Hydrolase
CMS1_k127_2520500_8	158190.SpiGrapes_1137	1.906e-112	369.0	COG0368@1|root,COG0368@2|Bacteria,2J8MP@203691|Spirochaetes	203691|Spirochaetes	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
CMS1_k127_2520500_11	158190.SpiGrapes_1138	5.083e-89	297.0	COG2087@1|root,COG2087@2|Bacteria,2J8UP@203691|Spirochaetes	203691|Spirochaetes	H	Cobinamide kinase cobinamide phosphate guanyltransferase	-	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
CMS1_k127_2560620_0	1195236.CTER_0468	3.328e-150	494.0	COG1874@1|root,COG1874@2|Bacteria,1TSHK@1239|Firmicutes	1239|Firmicutes	G	Belongs to the glycosyl hydrolase 35 family	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_35
CMS1_k127_2560620_1	1195236.CTER_0469	1.625e-64	230.0	COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3WIS9@541000|Ruminococcaceae	186801|Clostridia	P	ABC-type sugar transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_2560620_2	1195236.CTER_0470	1.325e-55	200.0	COG1175@1|root,COG1175@2|Bacteria,1TRI3@1239|Firmicutes	1239|Firmicutes	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_2594580_1	1410668.JNKC01000001_gene1937	3.956e-180	591.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,36DXT@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
CMS1_k127_2594580_0	158190.SpiGrapes_0624	1.75e-204	639.0	COG0480@1|root,COG0480@2|Bacteria,2J5D3@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS1_k127_260231_10	158190.SpiGrapes_2014	3.049e-136	435.0	COG2006@1|root,COG2006@2|Bacteria,2J6UZ@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS1_k127_260231_5	158190.SpiGrapes_2013	8.766e-192	602.0	COG0667@1|root,COG0667@2|Bacteria,2J7MP@203691|Spirochaetes	203691|Spirochaetes	C	aldo keto reductase family	-	-	-	ko:K18471	ko00640,map00640	-	R10718	RC00739	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
CMS1_k127_260231_7	158190.SpiGrapes_2012	5.254e-172	542.0	COG1082@1|root,COG1082@2|Bacteria,2JA6D@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS1_k127_260231_13	1125725.HMPREF1325_0677	1.034e-60	216.0	COG4126@1|root,COG4126@2|Bacteria,2JAD4@203691|Spirochaetes	203691|Spirochaetes	E	Asp/Glu/Hydantoin racemase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
CMS1_k127_260231_4	158190.SpiGrapes_2010	1.603e-196	614.0	COG3181@1|root,COG3181@2|Bacteria,2J9RU@203691|Spirochaetes	203691|Spirochaetes	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
CMS1_k127_260231_2	158190.SpiGrapes_2009	1.642e-307	945.0	COG3333@1|root,COG3333@2|Bacteria,2J9IV@203691|Spirochaetes	203691|Spirochaetes	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
CMS1_k127_260231_11	158190.SpiGrapes_2008	5.215e-79	267.0	2D5ZP@1|root,32TK5@2|Bacteria,2JAY8@203691|Spirochaetes	203691|Spirochaetes	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
CMS1_k127_260231_3	158190.SpiGrapes_2007	3.047e-203	634.0	COG1995@1|root,COG1995@2|Bacteria,2J9RX@203691|Spirochaetes	203691|Spirochaetes	C	Pyridoxal phosphate biosynthetic protein PdxA	-	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
CMS1_k127_260231_1	158190.SpiGrapes_2006	0.0	1065.0	COG3829@1|root,COG3829@2|Bacteria,2J9ME@203691|Spirochaetes	203691|Spirochaetes	K	propionate catabolism activator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PrpR_N,Sigma54_activat
CMS1_k127_260231_8	158190.SpiGrapes_2004	1.825e-144	463.0	COG0668@1|root,COG0668@2|Bacteria,2J6IE@203691|Spirochaetes	203691|Spirochaetes	M	mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
CMS1_k127_260231_0	158190.SpiGrapes_2003	0.0	1149.0	COG0326@1|root,COG0326@2|Bacteria,2J6JQ@203691|Spirochaetes	203691|Spirochaetes	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
CMS1_k127_260231_6	158190.SpiGrapes_2002	5.82e-191	603.0	COG1940@1|root,COG1940@2|Bacteria,2JABS@203691|Spirochaetes	203691|Spirochaetes	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
CMS1_k127_260231_9	158190.SpiGrapes_1998	2.157e-143	456.0	COG2186@1|root,COG2186@2|Bacteria,2J7JW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_260231_16	158190.SpiGrapes_1997	4.142e-47	172.0	COG2186@1|root,COG2186@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_2616765_1	1280680.AUJU01000008_gene188	2.416e-87	295.0	COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,4BW9U@830|Butyrivibrio	186801|Clostridia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K01176,ko:K05343	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459
CMS1_k127_2616765_2	720554.Clocl_0788	4.002e-86	294.0	COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,249QQ@186801|Clostridia,3WICS@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS1_k127_2616765_0	1123274.KB899420_gene4034	1.831e-116	379.0	COG0329@1|root,COG0329@2|Bacteria,2J7DD@203691|Spirochaetes	203691|Spirochaetes	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS1_k127_262437_5	1449065.JMLL01000016_gene3134	1.648e-75	268.0	COG3964@1|root,COG3964@2|Bacteria,1MVC7@1224|Proteobacteria,2TSUD@28211|Alphaproteobacteria,43J9W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	-	GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0052689	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
CMS1_k127_262437_8	1293054.HSACCH_00981	2.719e-67	239.0	COG0395@1|root,COG0395@2|Bacteria,1V3Y9@1239|Firmicutes,25C5H@186801|Clostridia,3WBP0@53433|Halanaerobiales	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_262437_9	1293054.HSACCH_00980	1.121e-65	235.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia,3WBQ6@53433|Halanaerobiales	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_262437_6	1415756.JQMY01000001_gene1863	3.796e-75	269.0	COG1653@1|root,COG1653@2|Bacteria,1PF41@1224|Proteobacteria,2VD9U@28211|Alphaproteobacteria,2PFV8@252301|Oceanicola	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
CMS1_k127_262437_7	309801.trd_1134	1.506e-69	249.0	COG1921@1|root,COG1921@2|Bacteria	2|Bacteria	E	L-seryl-tRNASec selenium transferase activity	-	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,Cys_Met_Meta_PP,SelA
CMS1_k127_262437_11	573413.Spirs_0831	3.653e-22	106.0	COG1802@1|root,COG1802@2|Bacteria,2JA9X@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_262437_10	1200792.AKYF01000009_gene3199	3.712e-45	168.0	COG0251@1|root,COG0251@2|Bacteria,1V6G4@1239|Firmicutes,4HMTM@91061|Bacilli,26XE2@186822|Paenibacillaceae	91061|Bacilli	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
CMS1_k127_262437_3	158190.SpiGrapes_1734	7.333e-101	337.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_262437_0	158190.SpiGrapes_1735	1.287e-207	652.0	COG3681@1|root,COG3681@2|Bacteria,2J6AS@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0597 family	-	-	-	-	-	-	-	-	-	-	-	-	SDH_alpha
CMS1_k127_262437_4	158190.SpiGrapes_1736	4.169e-93	309.0	COG1461@1|root,COG1461@2|Bacteria,2J85F@203691|Spirochaetes	203691|Spirochaetes	S	DAK2 domain	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
CMS1_k127_262437_1	158190.SpiGrapes_1737	3.904e-187	588.0	COG2376@1|root,COG2376@2|Bacteria,2J735@203691|Spirochaetes	203691|Spirochaetes	G	Dihydroxyacetone kinase	-	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1
CMS1_k127_262437_2	158190.SpiGrapes_1738	8.574e-134	428.0	COG0410@1|root,COG0410@2|Bacteria,2J5VQ@203691|Spirochaetes	2|Bacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
CMS1_k127_2652156_1	1499967.BAYZ01000027_gene1772	5.231e-88	297.0	COG0191@1|root,COG0191@2|Bacteria,2NPSG@2323|unclassified Bacteria	2|Bacteria	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
CMS1_k127_2652156_2	649747.HMPREF0083_01284	9.097e-64	228.0	COG1737@1|root,COG1737@2|Bacteria,1TR0N@1239|Firmicutes,4HB9E@91061|Bacilli,274GH@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
CMS1_k127_2652156_0	742733.HMPREF9469_01195	1.269e-102	346.0	COG1840@1|root,COG1840@2|Bacteria,1V5CP@1239|Firmicutes,24HGK@186801|Clostridia,22107@1506553|Lachnoclostridium	186801|Clostridia	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11,SBP_bac_6,SBP_bac_8
CMS1_k127_2652156_3	573413.Spirs_1784	1.152e-55	198.0	COG1178@1|root,COG1178@2|Bacteria,2J5J4@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
CMS1_k127_266374_5	1196323.ALKF01000177_gene1115	4.461e-24	109.0	COG1957@1|root,COG1957@2|Bacteria,1TSSS@1239|Firmicutes,4HB17@91061|Bacilli,275F5@186822|Paenibacillaceae	91061|Bacilli	F	Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively	rihC	-	3.2.2.1	ko:K01239,ko:K01250,ko:K12700	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
CMS1_k127_266374_2	158190.SpiGrapes_1605	1.469e-197	620.0	COG1609@1|root,COG1609@2|Bacteria,2JA9V@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_4
CMS1_k127_266374_1	158190.SpiGrapes_1604	1.887e-262	814.0	COG1653@1|root,COG1653@2|Bacteria,2J82N@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
CMS1_k127_266374_3	158190.SpiGrapes_1603	1.733e-173	546.0	COG1175@1|root,COG1175@2|Bacteria,2J7SD@203691|Spirochaetes	203691|Spirochaetes	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_266374_4	158190.SpiGrapes_1602	1.58e-159	508.0	COG0395@1|root,COG0395@2|Bacteria,2J786@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_266374_0	158190.SpiGrapes_1601	0.0	1410.0	COG1501@1|root,COG1501@2|Bacteria,2J722@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
CMS1_k127_2663815_3	158190.SpiGrapes_0624	6.858e-128	411.0	COG0480@1|root,COG0480@2|Bacteria,2J5D3@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS1_k127_2663815_5	158190.SpiGrapes_0625	3.138e-61	213.0	COG1396@1|root,COG1396@2|Bacteria,2J97D@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
CMS1_k127_2663815_4	545243.BAEV01000009_gene1236	1.394e-71	243.0	COG0346@1|root,COG0346@2|Bacteria,1V5IP@1239|Firmicutes,25B32@186801|Clostridia,36IEE@31979|Clostridiaceae	186801|Clostridia	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_2
CMS1_k127_2663815_1	158190.SpiGrapes_0626	0.0	1251.0	COG0480@1|root,COG0480@2|Bacteria,2J5YJ@203691|Spirochaetes	203691|Spirochaetes	J	translation elongation factor	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS1_k127_2663815_2	158190.SpiGrapes_0627	7.698e-133	428.0	COG0220@1|root,COG0220@2|Bacteria,2J5YX@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
CMS1_k127_2663815_0	158190.SpiGrapes_0628	0.0	1994.0	COG1197@1|root,COG1197@2|Bacteria,2J63X@203691|Spirochaetes	203691|Spirochaetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
CMS1_k127_2663815_6	158190.SpiGrapes_0629	3.286e-60	211.0	COG0483@1|root,COG0483@2|Bacteria,2J7MC@203691|Spirochaetes	203691|Spirochaetes	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS1_k127_2667569_3	742735.HMPREF9467_00148	4.731e-48	180.0	COG1802@1|root,COG1802@2|Bacteria,1V6NV@1239|Firmicutes,24KBH@186801|Clostridia,220VG@1506553|Lachnoclostridium	186801|Clostridia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_2667569_2	1209989.TepiRe1_0492	2.355e-99	342.0	COG0624@1|root,COG0624@2|Bacteria,1TPEG@1239|Firmicutes,247SK@186801|Clostridia,42F73@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M20	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_2667569_0	411902.CLOBOL_01129	1.374e-126	413.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,21YFW@1506553|Lachnoclostridium	186801|Clostridia	P	Psort location CytoplasmicMembrane, score 9.49	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_2667569_1	742733.HMPREF9469_02045	1.134e-115	381.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,21Y4B@1506553|Lachnoclostridium	186801|Clostridia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS1_k127_2686375_3	158190.SpiGrapes_2015	9.404e-43	164.0	COG1802@1|root,COG1802@2|Bacteria,2J8MW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_2686375_2	688269.Theth_0196	2.792e-44	175.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
CMS1_k127_2686375_5	1145276.T479_17925	3.397e-06	56.0	COG3090@1|root,COG3090@2|Bacteria,1VBG4@1239|Firmicutes,4HHAW@91061|Bacilli,3IXYE@400634|Lysinibacillus	91061|Bacilli	G	C4-dicarboxylate ABC transporter permease	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
CMS1_k127_2686375_0	1499967.BAYZ01000011_gene5205	1.425e-108	367.0	COG1593@1|root,COG1593@2|Bacteria	1499967.BAYZ01000011_gene5205|-	G	mannitol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2686375_1	1313265.JNIE01000002_gene875	1.888e-46	172.0	COG0698@1|root,COG0698@2|Bacteria,2G43P@200783|Aquificae	200783|Aquificae	G	ribose 5-phosphate isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
CMS1_k127_2686375_4	357809.Cphy_1819	1.446e-23	105.0	COG1957@1|root,COG1957@2|Bacteria,1TSSS@1239|Firmicutes,24A4D@186801|Clostridia,21XT8@1506553|Lachnoclostridium	186801|Clostridia	F	Inosine-uridine preferring nucleoside hydrolase	rihB	-	3.2.2.1,3.2.2.8	ko:K01239,ko:K01250,ko:K10213,ko:K12700	ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100	-	R01245,R01273,R01677,R01770,R02137,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
CMS1_k127_2724938_0	158190.SpiGrapes_0285	3.428e-191	602.0	COG1902@1|root,COG1902@2|Bacteria	2|Bacteria	C	pentaerythritol trinitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red,Oxidored_FMN
CMS1_k127_2724938_2	665956.HMPREF1032_01774	1.445e-93	314.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3WGIW@541000|Ruminococcaceae	186801|Clostridia	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
CMS1_k127_2724938_1	906968.Trebr_1563	1.969e-187	604.0	COG1053@1|root,COG1053@2|Bacteria,2J9JX@203691|Spirochaetes	203691|Spirochaetes	C	COGs COG1053 Succinate dehydrogenase fumarate reductase flavoprotein subunit	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
CMS1_k127_2724938_3	706433.HMPREF9430_00176	4.007e-76	268.0	COG1073@1|root,COG1073@2|Bacteria,1V7YW@1239|Firmicutes,3VRGU@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS1_k127_2724938_4	457421.CBFG_02153	1.293e-13	75.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia	186801|Clostridia	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_2736095_14	1449050.JNLE01000005_gene4660	1.349e-59	215.0	COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,36EYH@31979|Clostridiaceae	186801|Clostridia	S	MgtC SapB transporter	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
CMS1_k127_2736095_11	1449050.JNLE01000003_gene2481	1.077e-90	312.0	COG0235@1|root,COG0235@2|Bacteria,1V4BV@1239|Firmicutes,24I2N@186801|Clostridia,36RKS@31979|Clostridiaceae	186801|Clostridia	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
CMS1_k127_2736095_0	1280390.CBQR020000164_gene4355	7.47e-265	821.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HVE0@91061|Bacilli,271P8@186822|Paenibacillaceae	91061|Bacilli	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS1_k127_2736095_13	158189.SpiBuddy_2042	2.143e-63	221.0	COG2246@1|root,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
CMS1_k127_2736095_3	158189.SpiBuddy_2041	1.058e-228	719.0	COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_2736095_12	158189.SpiBuddy_2040	2.755e-72	250.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_2736095_15	1449050.JNLE01000005_gene4660	2.011e-58	211.0	COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,36EYH@31979|Clostridiaceae	186801|Clostridia	S	MgtC SapB transporter	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
CMS1_k127_2736095_7	33035.JPJF01000045_gene1058	1.787e-185	595.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,3XZ65@572511|Blautia	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
CMS1_k127_2736095_8	158190.SpiGrapes_3091	6.103e-132	425.0	COG0561@1|root,COG0561@2|Bacteria	2|Bacteria	Q	phosphatase activity	ggpS	-	2.4.1.213	ko:K03692	-	-	-	-	ko00000,ko01000	-	GT20	-	Glyco_transf_20,Hydrolase_3,S6PP
CMS1_k127_2736095_4	158190.SpiGrapes_3102	7.122e-194	612.0	COG3835@1|root,COG3835@2|Bacteria,2J8V3@203691|Spirochaetes	203691|Spirochaetes	K	sugar diacid	-	-	-	ko:K02647	-	-	-	-	ko00000,ko03000	-	-	-	Diacid_rec,HTH_30
CMS1_k127_2736095_2	158190.SpiGrapes_3097	3.688e-240	745.0	COG3875@1|root,COG3875@2|Bacteria,2J9IN@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF2088)	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
CMS1_k127_2736095_19	158190.SpiGrapes_3096	5.319e-11	63.0	COG1929@1|root,COG1929@2|Bacteria,2J5ZM@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
CMS1_k127_2736095_17	158190.SpiGrapes_3096	2.922e-13	72.0	COG1929@1|root,COG1929@2|Bacteria,2J5ZM@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
CMS1_k127_2736095_16	158190.SpiGrapes_3096	7.783e-15	78.0	COG1929@1|root,COG1929@2|Bacteria,2J5ZM@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
CMS1_k127_2736095_1	158190.SpiGrapes_3090	3.495e-241	747.0	COG1373@1|root,COG1373@2|Bacteria,2J5JQ@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1373 ATPase (AAA superfamily)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14
CMS1_k127_2736095_5	33035.JPJF01000101_gene3276	1.309e-192	612.0	COG2182@1|root,COG2182@2|Bacteria,1UI1M@1239|Firmicutes,25EAR@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2736095_9	33035.JPJF01000101_gene3275	4.752e-129	417.0	COG1175@1|root,COG1175@2|Bacteria,1TSRA@1239|Firmicutes,24E4R@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K17238	ko02010,map02010	M00207,M00599	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.38	-	-	BPD_transp_1
CMS1_k127_2736095_10	33035.JPJF01000101_gene3274	4.991e-118	385.0	COG0395@1|root,COG0395@2|Bacteria,1TRGH@1239|Firmicutes,24C7R@186801|Clostridia	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2736095_6	744872.Spica_1906	3.976e-192	634.0	COG0383@1|root,COG0383@2|Bacteria,2J78B@203691|Spirochaetes	203691|Spirochaetes	G	family 38 N-terminal domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
CMS1_k127_2736095_18	1499967.BAYZ01000016_gene6542	2.089e-11	68.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02103,ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_1,Peripla_BP_3
CMS1_k127_2743778_6	158190.SpiGrapes_0560	3.946e-19	87.0	COG0707@1|root,COG0707@2|Bacteria,2J5XF@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
CMS1_k127_2743778_0	158190.SpiGrapes_0561	0.0	1672.0	COG0653@1|root,COG0653@2|Bacteria,2J5UR@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS1_k127_2743778_5	350688.Clos_1991	2.325e-35	140.0	COG0454@1|root,COG0454@2|Bacteria,1UJN0@1239|Firmicutes,24X26@186801|Clostridia,36VEJ@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_2743778_2	158190.SpiGrapes_0581	3.554e-175	555.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,2JBGD@203691|Spirochaetes	203691|Spirochaetes	DM	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
CMS1_k127_2743778_1	158190.SpiGrapes_0582	1.115e-291	902.0	COG0768@1|root,COG0768@2|Bacteria,2J5D8@203691|Spirochaetes	203691|Spirochaetes	M	Cell division protein ftsI	pbp3	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
CMS1_k127_2743778_3	158190.SpiGrapes_0583	2.266e-165	526.0	COG1419@1|root,COG1419@2|Bacteria,2J5TV@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein FlhF	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
CMS1_k127_2743778_4	158190.SpiGrapes_0584	2.919e-116	375.0	COG1220@1|root,COG1220@2|Bacteria,2J68E@203691|Spirochaetes	203691|Spirochaetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
CMS1_k127_2746050_18	158190.SpiGrapes_1977	1.716e-74	250.0	COG1904@1|root,COG1904@2|Bacteria,2J5RQ@203691|Spirochaetes	203691|Spirochaetes	G	Glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
CMS1_k127_2746050_3	158190.SpiGrapes_1978	5.032e-295	909.0	COG2721@1|root,COG2721@2|Bacteria,2J6IB@203691|Spirochaetes	203691|Spirochaetes	G	D-galactarate dehydratase Altronate hydrolase	-	-	4.2.1.7	ko:K01685,ko:K16850	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
CMS1_k127_2746050_4	158189.SpiBuddy_3010	1.645e-222	699.0	COG0246@1|root,COG0385@1|root,COG0246@2|Bacteria,COG0385@2|Bacteria,2J5PW@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Mannitol dehydrogenase	-	-	1.1.1.58	ko:K00041	ko00040,ko01100,map00040,map01100	M00631	R02555	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
CMS1_k127_2746050_13	158190.SpiGrapes_1980	2.459e-143	461.0	COG0385@1|root,COG0385@2|Bacteria,2J7P4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Sodium Bile acid symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SBF
CMS1_k127_2746050_0	158190.SpiGrapes_1981	0.0	1351.0	COG0642@1|root,COG1609@1|root,COG2207@1|root,COG1609@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria,2J67C@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Peripla_BP_3
CMS1_k127_2746050_9	158190.SpiGrapes_1982	9.436e-177	556.0	COG4209@1|root,COG4209@2|Bacteria,2J78I@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
CMS1_k127_2746050_11	158190.SpiGrapes_1983	1.381e-166	527.0	COG0395@1|root,COG0395@2|Bacteria,2J6MZ@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
CMS1_k127_2746050_1	158190.SpiGrapes_1984	3.206e-315	968.0	COG1653@1|root,COG1653@2|Bacteria,2J66Q@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
CMS1_k127_2746050_7	158190.SpiGrapes_1985	5.56e-201	629.0	COG4225@1|root,COG4225@2|Bacteria,2J620@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Glycosyl Hydrolase Family 88	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
CMS1_k127_2746050_5	158190.SpiGrapes_1986	4.28e-219	682.0	COG1744@1|root,COG1744@2|Bacteria,2J66P@203691|Spirochaetes	203691|Spirochaetes	S	ABC-type transport system, periplasmic component surface lipoprotein	bmpD	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
CMS1_k127_2746050_2	158190.SpiGrapes_1987	3.023e-309	950.0	COG3845@1|root,COG3845@2|Bacteria,2J5GB@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter	rbsA	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_2746050_6	158190.SpiGrapes_1988	9.809e-214	667.0	COG4603@1|root,COG4603@2|Bacteria,2J6ER@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_2746050_8	158190.SpiGrapes_1989	3.942e-181	569.0	COG1079@1|root,COG1079@2|Bacteria,2J646@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_2746050_12	158190.SpiGrapes_1990	1.354e-148	473.0	COG0005@1|root,COG0005@2|Bacteria,2J585@203691|Spirochaetes	203691|Spirochaetes	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CMS1_k127_2746050_17	158190.SpiGrapes_1991	5.603e-76	258.0	COG3542@1|root,COG3542@2|Bacteria,2JBAD@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
CMS1_k127_2746050_16	158190.SpiGrapes_1992	3.464e-111	363.0	COG1028@1|root,COG1028@2|Bacteria,2JAG5@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100,1.1.1.385	ko:K00059,ko:K19548	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572,M00787	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R10917,R11671	RC00029,RC00117,RC00154	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS1_k127_2746050_14	158190.SpiGrapes_1993	2.229e-137	438.0	COG2129@1|root,COG2129@2|Bacteria,2J5J9@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS1_k127_2746050_10	158190.SpiGrapes_1994	1.189e-169	536.0	COG1475@1|root,COG1475@2|Bacteria,2J6CV@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2746050_15	158190.SpiGrapes_1995	3.637e-121	389.0	COG0655@1|root,COG0655@2|Bacteria,2JB8C@203691|Spirochaetes	203691|Spirochaetes	S	PFAM NADPH-dependent FMN reductase	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
CMS1_k127_2746050_19	158190.SpiGrapes_1996	4.183e-74	250.0	COG1119@1|root,COG1119@2|Bacteria,2J77C@203691|Spirochaetes	203691|Spirochaetes	P	ABC-type molybdenum transport system ATPase component photorepair protein PhrA	-	-	3.6.3.34	ko:K02013,ko:K05776	ko02010,map02010	M00189,M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS1_k127_2749444_0	158190.SpiGrapes_1842	0.0	1118.0	COG0425@1|root,COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0425@2|Bacteria,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2J5NQ@203691|Spirochaetes	203691|Spirochaetes	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
CMS1_k127_2749444_13	158190.SpiGrapes_1843	5.392e-28	113.0	COG2900@1|root,COG2900@2|Bacteria	2|Bacteria	S	Belongs to the SlyX family	slyX	-	-	ko:K03745	-	-	-	-	ko00000	-	-	-	SlyX
CMS1_k127_2749444_8	158190.SpiGrapes_1844	8.563e-187	586.0	COG2378@1|root,COG2378@2|Bacteria,2J9SS@203691|Spirochaetes	203691|Spirochaetes	K	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,WYL
CMS1_k127_2749444_12	158189.SpiBuddy_0083	1.807e-29	117.0	COG1773@1|root,COG1773@2|Bacteria,2J8V4@203691|Spirochaetes	203691|Spirochaetes	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
CMS1_k127_2749444_3	158190.SpiGrapes_1846	1.121e-291	919.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG3706@2|Bacteria,2JBH4@203691|Spirochaetes	203691|Spirochaetes	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,dCache_1
CMS1_k127_2749444_11	158190.SpiGrapes_1847	1.752e-83	278.0	COG0454@1|root,COG0456@2|Bacteria,2J7TA@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_2749444_6	158190.SpiGrapes_1848	1.119e-198	627.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	yfmI1	-	-	ko:K08220	-	-	-	-	ko00000,ko02000	2.A.1.28.1,2.A.1.28.4	-	-	MFS_1,MFS_3
CMS1_k127_2749444_10	158190.SpiGrapes_1849	4.373e-124	402.0	COG0778@1|root,COG0778@2|Bacteria,2JANH@203691|Spirochaetes	203691|Spirochaetes	C	nitroreductase	-	-	1.5.1.38	ko:K19285	ko00740,ko01100,map00740,map01100	-	R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
CMS1_k127_2749444_4	158190.SpiGrapes_1850	5.141e-291	900.0	COG2207@1|root,COG3835@1|root,COG4753@1|root,COG2207@2|Bacteria,COG3835@2|Bacteria,COG4753@2|Bacteria,2JBFZ@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
CMS1_k127_2749444_1	158190.SpiGrapes_1851	0.0	1011.0	COG2972@1|root,COG2972@2|Bacteria,2J6ZX@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
CMS1_k127_2749444_9	158190.SpiGrapes_1852	1.497e-148	476.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
CMS1_k127_2749444_7	158190.SpiGrapes_1853	3.486e-196	614.0	COG4211@1|root,COG4211@2|Bacteria,2J6DI@203691|Spirochaetes	203691|Spirochaetes	G	transport system permease	mglC	-	-	ko:K10541	ko02010,map02010	M00214	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.3	-	-	BPD_transp_2
CMS1_k127_2749444_2	158190.SpiGrapes_1854	3.043e-305	938.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	mglA	-	3.6.3.17	ko:K02056,ko:K10441,ko:K10542,ko:K10548,ko:K17215	ko02010,map02010	M00212,M00214,M00216,M00221,M00593	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.5	-	-	ABC_tran
CMS1_k127_2749444_5	158190.SpiGrapes_1855	2.023e-209	652.0	COG1879@1|root,COG1879@2|Bacteria,2J5Z1@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10540	ko02010,ko02030,map02010,map02030	M00214	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.3	-	-	Peripla_BP_4
CMS1_k127_2756918_7	158190.SpiGrapes_1043	1.368e-176	561.0	COG2972@1|root,COG2972@2|Bacteria,2J9TH@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,dCache_1
CMS1_k127_2756918_10	158190.SpiGrapes_1041	5.418e-95	313.0	COG0440@1|root,COG0440@2|Bacteria,2J7CQ@203691|Spirochaetes	203691|Spirochaetes	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
CMS1_k127_2756918_4	158190.SpiGrapes_1040	1.803e-210	655.0	COG0059@1|root,COG0059@2|Bacteria,2J60P@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
CMS1_k127_2756918_2	158190.SpiGrapes_1039	7.457e-317	974.0	COG0119@1|root,COG0119@2|Bacteria,2J702@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13,2.3.3.14	ko:K01649,ko:K02594	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R00271,R01213	RC00004,RC00067,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CMS1_k127_2756918_5	760011.Spico_0323	3.63e-206	654.0	COG0119@1|root,COG0119@2|Bacteria,2J6AF@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CMS1_k127_2756918_3	158190.SpiGrapes_1037	6.814e-264	815.0	COG0065@1|root,COG0065@2|Bacteria,2J5AM@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
CMS1_k127_2756918_9	158190.SpiGrapes_1036	3.526e-98	323.0	COG0066@1|root,COG0066@2|Bacteria,2J80G@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
CMS1_k127_2756918_6	158190.SpiGrapes_1035	3.993e-204	639.0	COG0473@1|root,COG0473@2|Bacteria,2J5FQ@203691|Spirochaetes	203691|Spirochaetes	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS1_k127_2756918_0	158190.SpiGrapes_1034	0.0	1043.0	COG0129@1|root,COG0129@2|Bacteria,2J68K@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
CMS1_k127_2756918_1	158190.SpiGrapes_1033	0.0	1029.0	COG0028@1|root,COG0028@2|Bacteria,2J5EZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS1_k127_2756918_12	158190.SpiGrapes_1031	5.659e-59	207.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin,Rubrerythrin
CMS1_k127_2756918_11	158190.SpiGrapes_1030	1.495e-68	238.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	ko:K02572	-	-	-	-	ko00000	-	-	-	Fer4_7
CMS1_k127_2756918_8	158190.SpiGrapes_1029	1.129e-99	329.0	COG0477@1|root,COG0477@2|Bacteria,2JBG8@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_2768627_10	158190.SpiGrapes_2186	4.745e-37	140.0	COG0268@1|root,COG0268@2|Bacteria	2|Bacteria	J	rRNA binding	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
CMS1_k127_2768627_8	158190.SpiGrapes_2187	3.79e-64	220.0	COG0776@1|root,COG0776@2|Bacteria,2J7PW@203691|Spirochaetes	203691|Spirochaetes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K04764,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS1_k127_2768627_0	158190.SpiGrapes_2188	0.0	1002.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
CMS1_k127_2768627_3	158190.SpiGrapes_2189	3.16e-231	721.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2J8AZ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM competence damage-inducible protein CinA N-terminal domain	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
CMS1_k127_2768627_1	158190.SpiGrapes_2190	1.188e-308	960.0	COG1158@1|root,COG4290@1|root,COG1158@2|Bacteria,COG4290@2|Bacteria,2J5BW@203691|Spirochaetes	203691|Spirochaetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CMS1_k127_2768627_11	158190.SpiGrapes_2191	2.555e-36	139.0	COG0254@1|root,COG0254@2|Bacteria,2J93Z@203691|Spirochaetes	203691|Spirochaetes	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
CMS1_k127_2768627_2	158190.SpiGrapes_2192	5.986e-237	734.0	COG0153@1|root,COG0153@2|Bacteria,2J58W@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
CMS1_k127_2768627_5	158190.SpiGrapes_2193	2.007e-145	465.0	COG0496@1|root,COG0496@2|Bacteria,2J7HR@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
CMS1_k127_2768627_9	158189.SpiBuddy_2792	9.727e-51	182.0	COG2983@1|root,COG2983@2|Bacteria,2JB4G@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0260 family	-	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	-
CMS1_k127_2768627_4	158190.SpiGrapes_2195	2.161e-222	692.0	COG1104@1|root,COG1104@2|Bacteria,2J6E2@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS1_k127_2768627_7	158190.SpiGrapes_2196	5.245e-120	388.0	COG0822@1|root,COG2906@1|root,COG0822@2|Bacteria,COG2906@2|Bacteria,2J6J3@203691|Spirochaetes	203691|Spirochaetes	C	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K04488,ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
CMS1_k127_2768627_6	158190.SpiGrapes_2200	2.566e-122	394.0	COG0441@1|root,COG0572@1|root,COG0441@2|Bacteria,COG0572@2|Bacteria,2J578@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribulokinase Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
CMS1_k127_2778577_4	158190.SpiGrapes_0135	8.356e-170	537.0	COG4254@1|root,COG4254@2|Bacteria,2J99I@203691|Spirochaetes	203691|Spirochaetes	S	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2778577_0	158190.SpiGrapes_0133	1.153e-305	949.0	COG0323@1|root,COG0323@2|Bacteria,2J5XE@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
CMS1_k127_2778577_2	158190.SpiGrapes_0131	9.26e-207	647.0	COG2937@1|root,COG2937@2|Bacteria,2JA0I@203691|Spirochaetes	203691|Spirochaetes	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
CMS1_k127_2778577_3	158190.SpiGrapes_0130	7.445e-185	580.0	COG0167@1|root,COG0167@2|Bacteria,2J972@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.1.1,1.3.98.1	ko:K00226,ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01867,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
CMS1_k127_2778577_7	158190.SpiGrapes_0129	3.877e-45	168.0	COG0716@1|root,COG0716@2|Bacteria,2J7U6@203691|Spirochaetes	203691|Spirochaetes	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3
CMS1_k127_2778577_6	158190.SpiGrapes_0128	2.274e-88	292.0	COG1522@1|root,COG1522@2|Bacteria,2JADV@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_AsnC-type
CMS1_k127_2778577_5	158190.SpiGrapes_0127	2.376e-130	417.0	COG1932@1|root,COG1932@2|Bacteria,2J5VB@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
CMS1_k127_2793400_0	158190.SpiGrapes_0010	1.397e-223	702.0	COG4942@1|root,COG4942@2|Bacteria,2J7BB@203691|Spirochaetes	203691|Spirochaetes	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
CMS1_k127_2793400_1	158190.SpiGrapes_0011	4.483e-221	690.0	COG0738@1|root,COG0738@2|Bacteria,2J7KW@203691|Spirochaetes	203691|Spirochaetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_2793400_2	158189.SpiBuddy_0433	1.363e-218	684.0	COG1653@1|root,COG1653@2|Bacteria,2J5AA@203691|Spirochaetes	203691|Spirochaetes	G	solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2793400_3	158189.SpiBuddy_0434	4.928e-140	451.0	COG1175@1|root,COG1175@2|Bacteria,2J5Q4@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2793400_5	180332.JTGN01000006_gene3459	1.221e-122	398.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,249NY@186801|Clostridia	186801|Clostridia	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2793400_4	1235798.C817_02827	3.087e-128	412.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia	186801|Clostridia	G	family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
CMS1_k127_280842_3	545695.TREAZ_1906	2.301e-08	61.0	COG0582@1|root,COG0582@2|Bacteria,2JA69@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
CMS1_k127_280842_0	158189.SpiBuddy_1722	1.178e-85	287.0	COG0605@1|root,COG0605@2|Bacteria,2J7W6@203691|Spirochaetes	203691|Spirochaetes	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
CMS1_k127_280842_2	158189.SpiBuddy_1721	2.647e-61	214.0	2DDSD@1|root,2ZJ2I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_280842_1	158190.SpiGrapes_0027	3.601e-78	262.0	COG3333@1|root,COG3333@2|Bacteria,2J70X@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
CMS1_k127_2821909_15	994573.T472_0203810	1.047e-10	69.0	COG3464@1|root,COG3464@2|Bacteria,1TQ93@1239|Firmicutes,24AMP@186801|Clostridia,36HW3@31979|Clostridiaceae	186801|Clostridia	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
CMS1_k127_2821909_9	1536774.H70357_25890	2.857e-85	285.0	COG1695@1|root,COG1695@2|Bacteria,1UYFE@1239|Firmicutes,4HJI9@91061|Bacilli,26Y4U@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS1_k127_2821909_7	138119.DSY0557	2.337e-107	353.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,263KT@186807|Peptococcaceae	186801|Clostridia	V	transport system, ATPase	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS1_k127_2821909_8	1536774.H70357_25900	1.689e-105	347.0	COG0842@1|root,COG0842@2|Bacteria,1TSP0@1239|Firmicutes,4HK7M@91061|Bacilli,26Z8W@186822|Paenibacillaceae	91061|Bacilli	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS1_k127_2821909_4	887929.HMP0721_1183	1.445e-181	579.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia,25ZHC@186806|Eubacteriaceae	186801|Clostridia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS1_k127_2821909_3	158190.SpiGrapes_2634	1.796e-188	600.0	COG0642@1|root,COG2205@2|Bacteria,2J7ZP@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS1_k127_2821909_12	246194.CHY_2567	7.608e-63	223.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia,42G5A@68295|Thermoanaerobacterales	186801|Clostridia	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483,ko:K18344	ko01502,ko02020,map01502,map02020	M00651,M00656	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_2821909_14	158190.SpiGrapes_2636	8.19e-31	123.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
CMS1_k127_2821909_6	158190.SpiGrapes_2637	1.627e-141	454.0	COG0384@1|root,COG0384@2|Bacteria,2J9Y9@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM phenazine biosynthesis protein PhzF family	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
CMS1_k127_2821909_0	158190.SpiGrapes_2638	1.632e-291	898.0	COG1129@1|root,COG1129@2|Bacteria,2J64A@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS1_k127_2821909_1	158190.SpiGrapes_2639	3.899e-231	719.0	COG1172@1|root,COG1172@2|Bacteria,2J7N5@203691|Spirochaetes	203691|Spirochaetes	G	COG1172 Ribose xylose arabinose galactoside ABC-type transport systems, permease components	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS1_k127_2821909_2	158190.SpiGrapes_2640	2.297e-218	681.0	COG1879@1|root,COG1879@2|Bacteria,2J800@203691|Spirochaetes	203691|Spirochaetes	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
CMS1_k127_2821909_5	158190.SpiGrapes_2641	2.497e-167	533.0	COG1609@1|root,COG1609@2|Bacteria,2J6QG@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_2821909_11	158190.SpiGrapes_2642	5.793e-67	230.0	2DP9R@1|root,3315G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
CMS1_k127_2821909_13	158190.SpiGrapes_2643	3.635e-62	216.0	COG2731@1|root,COG2731@2|Bacteria,2J8SC@203691|Spirochaetes	203691|Spirochaetes	G	YhcH YjgK YiaL family	-	-	-	-	-	-	-	-	-	-	-	-	DUF386
CMS1_k127_2821909_16	592028.GCWU000321_00562	4.554e-06	52.0	2DGDE@1|root,2ZVI3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2821909_10	760011.Spico_1155	1.634e-71	243.0	COG1518@1|root,COG1518@2|Bacteria	2|Bacteria	L	maintenance of DNA repeat elements	cas1	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1
CMS1_k127_2825710_4	158190.SpiGrapes_3152	5.37e-187	584.0	COG0624@1|root,COG0624@2|Bacteria,2J6C1@203691|Spirochaetes	203691|Spirochaetes	E	Selenium metabolism hydrolase	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS1_k127_2825710_1	158190.SpiGrapes_3156	4.233e-280	863.0	COG0402@1|root,COG0402@2|Bacteria,2J6KS@203691|Spirochaetes	203691|Spirochaetes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS1_k127_2825710_6	158190.SpiGrapes_3157	6.757e-140	448.0	COG1319@1|root,COG1319@2|Bacteria,2JAY9@203691|Spirochaetes	203691|Spirochaetes	C	PFAM FAD binding domain in molybdopterin dehydrogenase	-	-	-	ko:K12529	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS1_k127_2825710_0	158190.SpiGrapes_3158	0.0	1818.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2JA0V@203691|Spirochaetes	203691|Spirochaetes	C	xanthine dehydrogenase, a b hammerhead	-	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
CMS1_k127_2825710_2	158190.SpiGrapes_3159	1.538e-251	780.0	COG0078@1|root,COG0078@2|Bacteria,2J5Q3@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the ATCase OTCase family	ygeW	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
CMS1_k127_2825710_5	158190.SpiGrapes_3160	1.979e-144	461.0	COG1453@1|root,COG1453@2|Bacteria,2J89X@203691|Spirochaetes	203691|Spirochaetes	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS1_k127_2825710_8	158190.SpiGrapes_3161	4.866e-72	252.0	2BFK3@1|root,329E6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2825710_7	1195236.CTER_3533	2.863e-80	274.0	COG0348@1|root,COG0348@2|Bacteria,1V66G@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_9
CMS1_k127_2825710_3	158190.SpiGrapes_3172	3.242e-191	604.0	COG2081@1|root,COG2081@2|Bacteria,2J83X@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM flavoprotein, HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
CMS1_k127_2827859_8	158190.SpiGrapes_0468	1.842e-89	297.0	COG4660@1|root,COG4660@2|Bacteria,2J58U@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rsxE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS1_k127_2827859_9	158190.SpiGrapes_0469	1.562e-87	293.0	COG4659@1|root,COG4659@2|Bacteria	2|Bacteria	C	FMN binding	rnfG	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009279,GO:0016020,GO:0016491,GO:0016651,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0055114,GO:0071944	-	ko:K03612,ko:K03613,ko:K21559	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind
CMS1_k127_2827859_4	158190.SpiGrapes_0470	8.277e-206	643.0	COG4658@1|root,COG4658@2|Bacteria,2J639@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
CMS1_k127_2827859_1	158190.SpiGrapes_0471	1.024e-263	814.0	COG4656@1|root,COG4656@2|Bacteria,2J5TG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_8,RnfC_N,SLBB
CMS1_k127_2827859_6	158190.SpiGrapes_0472	1.324e-175	552.0	COG1302@1|root,COG1302@2|Bacteria,2J6I6@203691|Spirochaetes	203691|Spirochaetes	S	Associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2827859_3	158190.SpiGrapes_0473	5.741e-242	753.0	COG0617@1|root,COG0617@2|Bacteria,2J5VH@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
CMS1_k127_2827859_2	158190.SpiGrapes_0474	5.267e-252	782.0	COG0124@1|root,COG0124@2|Bacteria,2J5DX@203691|Spirochaetes	203691|Spirochaetes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
CMS1_k127_2827859_0	158190.SpiGrapes_0475	0.0	1499.0	COG1643@1|root,COG1643@2|Bacteria,2J58M@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	hrpA	-	-	-	-	-	-	-	-	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
CMS1_k127_2827859_5	158190.SpiGrapes_0476	4.229e-195	612.0	COG0337@1|root,COG0337@2|Bacteria,2J69J@203691|Spirochaetes	203691|Spirochaetes	H	3-dehydroquinate synthase	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
CMS1_k127_2827859_7	158190.SpiGrapes_0477	1.746e-161	515.0	COG1104@1|root,COG1104@2|Bacteria,2J5VR@203691|Spirochaetes	203691|Spirochaetes	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS1_k127_2833111_2	56780.SYN_02634	1.844e-207	655.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,42MNR@68525|delta/epsilon subdivisions,2WJ70@28221|Deltaproteobacteria,2MQFU@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Elongator protein 3, MiaB family, Radical SAM	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
CMS1_k127_2833111_8	158190.SpiGrapes_0096	1.094e-131	425.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	2.3.1.264	ko:K07025,ko:K21935	-	-	R11701	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
CMS1_k127_2833111_0	158190.SpiGrapes_0095	2.203e-264	820.0	COG0277@1|root,COG0277@2|Bacteria,2J6Z1@203691|Spirochaetes	203691|Spirochaetes	C	FAD binding domain	-	-	1.1.3.15,2.5.1.26	ko:K00104,ko:K00803	ko00565,ko00630,ko01100,ko01110,ko01120,ko01130,ko04146,map00565,map00630,map01100,map01110,map01120,map01130,map04146	-	R00475,R04311	RC00020,RC00042,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS1_k127_2833111_6	158190.SpiGrapes_0094	5.896e-171	541.0	COG2025@1|root,COG2025@2|Bacteria,2J5XR@203691|Spirochaetes	203691|Spirochaetes	C	Electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS1_k127_2833111_9	158190.SpiGrapes_0093	1.244e-130	422.0	COG2086@1|root,COG2086@2|Bacteria,2J6CP@203691|Spirochaetes	203691|Spirochaetes	C	Electron transfer flavoprotein	etfB	-	1.3.1.108	ko:K03521,ko:K22431	-	-	-	-	ko00000,ko01000	-	-	-	ETF
CMS1_k127_2833111_1	158190.SpiGrapes_0092	9.828e-247	766.0	COG1653@1|root,COG1653@2|Bacteria,2J70I@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
CMS1_k127_2833111_5	158190.SpiGrapes_0091	8.248e-178	559.0	COG1175@1|root,COG1175@2|Bacteria,2J6WK@203691|Spirochaetes	203691|Spirochaetes	P	transporter	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_2833111_7	158190.SpiGrapes_0090	6.084e-154	492.0	COG0395@1|root,COG0395@2|Bacteria,2J70J@203691|Spirochaetes	203691|Spirochaetes	P	ABC-type sugar transport system, permease component	-	-	-	ko:K10119,ko:K10202	ko02010,map02010	M00196,M00205	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.18,3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_2833111_4	158190.SpiGrapes_0088	7.522e-184	579.0	COG0709@1|root,COG0709@2|Bacteria,2J6VU@203691|Spirochaetes	203691|Spirochaetes	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
CMS1_k127_2833111_10	158190.SpiGrapes_0087	1.616e-31	124.0	2EKBE@1|root,33E1T@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3343
CMS1_k127_2833111_11	158190.SpiGrapes_0086	6.94e-24	102.0	COG0425@1|root,COG0425@2|Bacteria,2J8IN@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
CMS1_k127_2833111_3	158190.SpiGrapes_0085	5.304e-190	597.0	COG2391@1|root,COG2391@2|Bacteria,2J5W3@203691|Spirochaetes	203691|Spirochaetes	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
CMS1_k127_2833111_12	158190.SpiGrapes_0084	4.375e-22	96.0	COG0520@1|root,COG0520@2|Bacteria,2J6VX@203691|Spirochaetes	203691|Spirochaetes	E	cysteine desulfurase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS1_k127_28350_0	158190.SpiGrapes_3068	1.535e-271	839.0	COG0448@1|root,COG0448@2|Bacteria,2J5UB@203691|Spirochaetes	203691|Spirochaetes	H	Glucose-1-phosphate adenylyltransferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS1_k127_28350_1	158190.SpiGrapes_3069	7.747e-245	762.0	COG0297@1|root,COG0297@2|Bacteria,2J5B0@203691|Spirochaetes	203691|Spirochaetes	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
CMS1_k127_28350_6	158190.SpiGrapes_3070	1.252e-174	552.0	COG0492@1|root,COG0492@2|Bacteria,2J7WA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS1_k127_28350_13	760011.Spico_0933	4.151e-50	188.0	COG1214@1|root,COG1214@2|Bacteria,2J80U@203691|Spirochaetes	203691|Spirochaetes	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
CMS1_k127_28350_10	158190.SpiGrapes_3072	1.892e-74	254.0	COG0802@1|root,COG0802@2|Bacteria,2J8H4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0079, ATPase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
CMS1_k127_28350_2	158190.SpiGrapes_3073	9.677e-222	695.0	COG5010@1|root,COG5010@2|Bacteria,2JBGJ@203691|Spirochaetes	203691|Spirochaetes	U	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
CMS1_k127_28350_11	158190.SpiGrapes_3075	6.731e-67	229.0	COG0292@1|root,COG0292@2|Bacteria,2J82V@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
CMS1_k127_28350_14	158190.SpiGrapes_3076	1.171e-29	119.0	COG0291@1|root,COG0291@2|Bacteria,2J8RR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
CMS1_k127_28350_8	158190.SpiGrapes_3077	1.032e-99	329.0	COG0290@1|root,COG0290@2|Bacteria,2J76T@203691|Spirochaetes	203691|Spirochaetes	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CMS1_k127_28350_4	158190.SpiGrapes_3078	7.141e-207	645.0	COG0191@1|root,COG0191@2|Bacteria,2J5IR@203691|Spirochaetes	203691|Spirochaetes	G	aldolase class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
CMS1_k127_28350_7	158190.SpiGrapes_3080	1.857e-105	349.0	COG0084@1|root,COG0084@2|Bacteria,2J8FE@203691|Spirochaetes	203691|Spirochaetes	L	Hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS1_k127_28350_9	158190.SpiGrapes_3081	8.079e-76	258.0	COG0716@1|root,COG0716@2|Bacteria,2J8YC@203691|Spirochaetes	203691|Spirochaetes	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
CMS1_k127_28350_3	411461.DORFOR_02542	1.13e-207	655.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,27W0U@189330|Dorea	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS1_k127_28350_5	1125699.HMPREF9194_00906	5.116e-176	574.0	COG0383@1|root,COG0383@2|Bacteria,2J9AQ@203691|Spirochaetes	203691|Spirochaetes	G	alpha-mannosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5054
CMS1_k127_2835116_2	158190.SpiGrapes_0326	7.482e-219	699.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,2JBH4@203691|Spirochaetes	203691|Spirochaetes	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,dCache_1
CMS1_k127_2835116_0	158190.SpiGrapes_0325	1.72e-302	930.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2J5K7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
CMS1_k127_2835116_1	158190.SpiGrapes_0324	2.498e-263	817.0	COG5476@1|root,COG5476@2|Bacteria,2J598@203691|Spirochaetes	203691|Spirochaetes	S	MlrC domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
CMS1_k127_2835116_3	158190.SpiGrapes_0323	1.165e-182	578.0	COG0640@1|root,COG1940@1|root,COG0640@2|Bacteria,COG1940@2|Bacteria,2J9T1@203691|Spirochaetes	203691|Spirochaetes	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
CMS1_k127_2835116_4	158190.SpiGrapes_0322	2.157e-132	426.0	COG3142@1|root,COG3142@2|Bacteria,2J7H5@203691|Spirochaetes	203691|Spirochaetes	P	Participates in the control of copper homeostasis	cutC	-	-	ko:K06201	-	-	-	-	ko00000	-	-	-	CutC
CMS1_k127_2835116_5	158190.SpiGrapes_0318	3.288e-84	282.0	COG0366@1|root,COG0366@2|Bacteria,2J6U5@203691|Spirochaetes	203691|Spirochaetes	G	Alpha amylase, catalytic domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase
CMS1_k127_2851773_1	158190.SpiGrapes_0702	2.657e-242	753.0	COG2723@1|root,COG2723@2|Bacteria,2J6C8@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21,3.2.1.86	ko:K01223,ko:K05350	ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110	-	R00026,R00839,R02558,R02887,R02985,R03527,R04949,R04998,R05133,R05134,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GT1	-	Glyco_hydro_1
CMS1_k127_2851773_7	158189.SpiBuddy_1169	7.225e-06	49.0	COG1011@1|root,COG1011@2|Bacteria,2J7J2@203691|Spirochaetes	203691|Spirochaetes	E	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_2851773_3	158190.SpiGrapes_0705	1.115e-142	455.0	COG0708@1|root,COG0708@2|Bacteria,2J62E@203691|Spirochaetes	203691|Spirochaetes	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
CMS1_k127_2851773_0	158190.SpiGrapes_0706	0.0	1157.0	COG1217@1|root,COG1217@2|Bacteria,2J9HZ@203691|Spirochaetes	203691|Spirochaetes	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
CMS1_k127_2851773_2	158190.SpiGrapes_0707	9.698e-192	605.0	COG0738@1|root,COG0738@2|Bacteria,2JA67@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_2851773_5	158190.SpiGrapes_0708	9.674e-61	214.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	ywnH	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4,HTH_20
CMS1_k127_2851773_4	158190.SpiGrapes_0709	2.678e-68	234.0	COG0394@1|root,COG0394@2|Bacteria	2|Bacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
CMS1_k127_2851773_6	158190.SpiGrapes_0710	4.082e-23	99.0	COG0526@1|root,COG0526@2|Bacteria,2J91P@203691|Spirochaetes	203691|Spirochaetes	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
CMS1_k127_2854385_2	933262.AXAM01000088_gene302	9.682e-88	298.0	COG4637@1|root,COG4637@2|Bacteria,1ND40@1224|Proteobacteria,42MR3@68525|delta/epsilon subdivisions,2WKWG@28221|Deltaproteobacteria,2MM4Y@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
CMS1_k127_2854385_3	933262.AXAM01000088_gene301	6.373e-56	203.0	arCOG06916@1|root,30456@2|Bacteria,1R83C@1224|Proteobacteria,42UQB@68525|delta/epsilon subdivisions,2WPE3@28221|Deltaproteobacteria,2MPKV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4276)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
CMS1_k127_2854385_0	158190.SpiGrapes_0874	0.0	1320.0	COG0419@1|root,COG0419@2|Bacteria	2|Bacteria	L	ATPase involved in DNA repair	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,AAA_27
CMS1_k127_2854385_1	158190.SpiGrapes_0875	1.272e-175	559.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
CMS1_k127_2854385_4	158190.SpiGrapes_0876	1.339e-50	180.0	COG0724@1|root,COG0724@2|Bacteria,2J8UF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS1_k127_2879684_2	158190.SpiGrapes_0001	3.071e-190	597.0	COG0687@1|root,COG0687@2|Bacteria,2J8G5@203691|Spirochaetes	203691|Spirochaetes	E	Spermidine putrescine ABC transporter	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
CMS1_k127_2879684_0	158190.SpiGrapes_3283	2.163e-286	884.0	COG0591@1|root,COG0591@2|Bacteria,2J5R8@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
CMS1_k127_2879684_5	158190.SpiGrapes_3282	1.452e-92	310.0	COG0491@1|root,COG0491@2|Bacteria,2JBBK@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_2879684_8	158190.SpiGrapes_3281	1.748e-53	193.0	COG1670@1|root,COG1670@2|Bacteria,2J8V7@203691|Spirochaetes	203691|Spirochaetes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_2879684_4	158190.SpiGrapes_3280	2.003e-110	361.0	COG0005@1|root,COG0005@2|Bacteria	2|Bacteria	F	purine-nucleoside phosphorylase activity	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS1_k127_2879684_3	158190.SpiGrapes_3279	9.46e-153	488.0	COG0182@1|root,COG0182@2|Bacteria,2J5FH@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
CMS1_k127_2879684_6	158190.SpiGrapes_3278	1.358e-87	292.0	COG0590@1|root,COG0590@2|Bacteria	2|Bacteria	FJ	tRNA wobble adenosine to inosine editing	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	dCMP_cyt_deam_1
CMS1_k127_2879684_1	158190.SpiGrapes_3277	5.562e-201	633.0	COG0545@1|root,COG0545@2|Bacteria,2J77J@203691|Spirochaetes	203691|Spirochaetes	M	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
CMS1_k127_2879684_7	158190.SpiGrapes_3276	2.479e-86	291.0	COG1802@1|root,COG1802@2|Bacteria,2J8MW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_2879913_2	158190.SpiGrapes_0150	2.458e-114	374.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10189,ko:K10228,ko:K10241,ko:K15771,ko:K17242,ko:K17316	ko02010,map02010	M00196,M00198,M00199,M00200,M00206,M00207,M00491,M00600,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.39,3.A.1.1.4,3.A.1.1.5	-	-	BPD_transp_1
CMS1_k127_2879913_1	742735.HMPREF9467_00152	3.732e-127	412.0	COG0395@1|root,COG0395@2|Bacteria,1VR34@1239|Firmicutes,24YXT@186801|Clostridia,21ZI0@1506553|Lachnoclostridium	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2879913_0	158190.SpiGrapes_2355	3.288e-161	514.0	COG0679@1|root,COG0679@2|Bacteria,2J8BY@203691|Spirochaetes	203691|Spirochaetes	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
CMS1_k127_2879913_3	1123511.KB905842_gene1512	7.217e-87	291.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,4H4ND@909932|Negativicutes	909932|Negativicutes	M	Acetyltransferase (GNAT) domain	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
CMS1_k127_2879913_4	1122599.AUGR01000005_gene1771	2e-10	67.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RQAG@1236|Gammaproteobacteria,1XIM2@135619|Oceanospirillales	135619|Oceanospirillales	K	transcriptional regulator	-	-	-	ko:K21826	-	-	-	-	ko00000,ko03000	-	-	-	DJ-1_PfpI,HTH_18
CMS1_k127_2882225_10	158190.SpiGrapes_0759	2.467e-109	359.0	COG1296@1|root,COG1296@2|Bacteria,2J5GM@203691|Spirochaetes	203691|Spirochaetes	E	branched-chain amino acid permease (azaleucine resistance)	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
CMS1_k127_2882225_14	158190.SpiGrapes_0760	9.399e-43	158.0	2DEA9@1|root,2ZM5I@2|Bacteria,2JB6M@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Branched-chain amino acid transport	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
CMS1_k127_2882225_19	1265507.KB899642_gene2664	1.912e-07	61.0	COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,1RP5T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Deoxyribonuclease	yjjV	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS1_k127_2882225_8	158190.SpiGrapes_0762	1.671e-128	414.0	COG1179@1|root,COG1179@2|Bacteria,2J7ER@203691|Spirochaetes	203691|Spirochaetes	H	COGs COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1	-	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
CMS1_k127_2882225_16	760011.Spico_0774	1.472e-35	144.0	COG2199@1|root,COG3706@2|Bacteria,2JB5B@203691|Spirochaetes	203691|Spirochaetes	T	Carbohydrate-binding family 9	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_2
CMS1_k127_2882225_9	158190.SpiGrapes_0764	1.034e-117	387.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Lactonase,PKD
CMS1_k127_2882225_12	158190.SpiGrapes_0765	2.1e-65	225.0	COG0824@1|root,COG0824@2|Bacteria,2J7D2@203691|Spirochaetes	203691|Spirochaetes	S	PFAM thioesterase superfamily	fcbC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
CMS1_k127_2882225_1	158190.SpiGrapes_0766	3.204e-247	768.0	COG0019@1|root,COG0019@2|Bacteria,2J5HV@203691|Spirochaetes	203691|Spirochaetes	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS1_k127_2882225_2	158190.SpiGrapes_0767	8.27e-243	758.0	COG0436@1|root,COG0436@2|Bacteria,2J6H6@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_2882225_4	158190.SpiGrapes_0768	2.329e-177	557.0	COG0329@1|root,COG0329@2|Bacteria,2J5J6@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS1_k127_2882225_7	158190.SpiGrapes_0769	2.365e-144	461.0	COG0289@1|root,COG0289@2|Bacteria,2J647@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
CMS1_k127_2882225_0	158190.SpiGrapes_0770	0.0	1309.0	COG0550@1|root,COG0550@2|Bacteria,2J7HJ@203691|Spirochaetes	203691|Spirochaetes	L	TIGRFAM DNA topoisomerase III, bacteria and conjugative plasmid	-	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim
CMS1_k127_2882225_15	158190.SpiGrapes_0771	4.911e-36	137.0	COG2221@1|root,COG2221@2|Bacteria,2JB8I@203691|Spirochaetes	203691|Spirochaetes	C	Nitrite and sulphite reductase 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2882225_11	158190.SpiGrapes_0772	1.01e-77	267.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_10,Fer4_5,Fer4_9
CMS1_k127_2882225_17	158190.SpiGrapes_0774	3.975e-29	116.0	COG2768@1|root,COG2768@2|Bacteria,2J9CG@203691|Spirochaetes	203691|Spirochaetes	C	PFAM 4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
CMS1_k127_2882225_3	158190.SpiGrapes_0776	1.461e-206	648.0	COG1570@1|root,COG1570@2|Bacteria,2J5ED@203691|Spirochaetes	203691|Spirochaetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
CMS1_k127_2882225_18	158190.SpiGrapes_0777	2.156e-27	111.0	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
CMS1_k127_2882225_5	158190.SpiGrapes_0778	1.66e-169	534.0	COG0788@1|root,COG0788@2|Bacteria,2J7GR@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_N
CMS1_k127_2882225_6	158190.SpiGrapes_0779	5.786e-160	507.0	COG0004@1|root,COG0347@1|root,COG0004@2|Bacteria,COG0347@2|Bacteria,2J5W4@203691|Spirochaetes	203691|Spirochaetes	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
CMS1_k127_2886978_3	158190.SpiGrapes_0353	4.197e-31	122.0	COG1452@1|root,COG1452@2|Bacteria,2J5EC@203691|Spirochaetes	203691|Spirochaetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2886978_1	158189.SpiBuddy_1440	1.039e-137	444.0	COG1702@1|root,COG1702@2|Bacteria,2J64H@203691|Spirochaetes	203691|Spirochaetes	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
CMS1_k127_2886978_0	158190.SpiGrapes_0355	2e-323	1005.0	COG1480@1|root,COG1480@2|Bacteria,2J5K4@203691|Spirochaetes	203691|Spirochaetes	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
CMS1_k127_2886978_2	158190.SpiGrapes_0356	1.641e-64	224.0	COG0319@1|root,COG0319@2|Bacteria	2|Bacteria	C	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.6.99.2,3.5.4.5	ko:K01489,ko:K03474,ko:K03595,ko:K07042	ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100	M00124	R01878,R02485,R05838,R08221	RC00074,RC00514,RC01476	ko00000,ko00001,ko00002,ko01000,ko03009,ko03029	-	-	-	UPF0054
CMS1_k127_2893651_2	158190.SpiGrapes_0287	1.607e-106	351.0	COG1378@1|root,COG1378@2|Bacteria,2J8K3@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
CMS1_k127_2893651_1	158190.SpiGrapes_0279	1.426e-163	520.0	COG0330@1|root,COG0330@2|Bacteria,2J7AC@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS1_k127_2893651_3	158190.SpiGrapes_0278	4.702e-24	102.0	COG4877@1|root,COG4877@2|Bacteria,2J8S8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2893651_0	158190.SpiGrapes_0277	0.0	1083.0	COG0737@1|root,COG0737@2|Bacteria,2J5ZK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
CMS1_k127_2893651_4	1227349.C170_27223	1.912e-07	53.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,4HCGH@91061|Bacilli,26RKZ@186822|Paenibacillaceae	91061|Bacilli	G	Catalyses the hydrolysis of terminal non-reducing alpha-D-galactose residues in alpha-D-galactosides	melA	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
CMS1_k127_2896783_1	158190.SpiGrapes_0742	1.183e-232	725.0	COG1269@1|root,COG1269@2|Bacteria,2J6DX@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
CMS1_k127_2896783_3	158190.SpiGrapes_0743	8.277e-184	580.0	COG1527@1|root,COG1527@2|Bacteria,2JADK@203691|Spirochaetes	203691|Spirochaetes	C	PFAM ATP synthase (C AC39) subunit	-	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
CMS1_k127_2896783_0	158190.SpiGrapes_0745	0.0	1281.0	COG3188@1|root,COG3188@2|Bacteria,2JB5D@203691|Spirochaetes	203691|Spirochaetes	NU	usher protein	-	-	-	ko:K07347	ko05133,map05133	-	-	-	ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3	-	-	-
CMS1_k127_2896783_5	158190.SpiGrapes_0746	1.252e-126	408.0	COG3121@1|root,COG3121@2|Bacteria,2JATE@203691|Spirochaetes	203691|Spirochaetes	NU	Pili and flagellar-assembly chaperone, PapD N-terminal domain	-	-	-	ko:K07346	-	-	-	-	ko00000,ko02035,ko02044,ko03110	-	-	-	PapD_N
CMS1_k127_2896783_7	158190.SpiGrapes_0747	1.526e-84	283.0	COG1309@1|root,COG1309@2|Bacteria,2J98E@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
CMS1_k127_2896783_8	573413.Spirs_0663	2.704e-71	243.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
CMS1_k127_2896783_2	158190.SpiGrapes_0749	6.178e-201	635.0	COG1409@1|root,COG1409@2|Bacteria,2JANM@203691|Spirochaetes	203691|Spirochaetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K22390	-	-	-	-	ko00000	-	-	-	Metallophos
CMS1_k127_2896783_9	1232410.KI421421_gene3801	2.334e-43	167.0	COG2121@1|root,COG2121@2|Bacteria,1NA4P@1224|Proteobacteria,43EYE@68525|delta/epsilon subdivisions,2X26A@28221|Deltaproteobacteria,43V8K@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	-
CMS1_k127_2896783_4	158190.SpiGrapes_0752	2.549e-146	471.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS1_k127_2896783_6	158190.SpiGrapes_0753	7.568e-88	293.0	COG0438@1|root,COG1409@1|root,COG0438@2|Bacteria,COG1409@2|Bacteria,2J7E2@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS1_k127_2899173_4	394503.Ccel_3225	1.05e-85	293.0	COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,249QQ@186801|Clostridia,36G1Q@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS1_k127_2899173_3	180332.JTGN01000018_gene55	2.238e-107	356.0	COG0395@1|root,COG0395@2|Bacteria,1UCH2@1239|Firmicutes,24AS5@186801|Clostridia	186801|Clostridia	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_2899173_2	180332.JTGN01000018_gene54	3.276e-112	368.0	COG1175@1|root,COG1175@2|Bacteria,1V2TM@1239|Firmicutes,24H6J@186801|Clostridia	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_2899173_0	180332.JTGN01000018_gene53	2.915e-145	473.0	COG1653@1|root,COG1653@2|Bacteria,1TR8U@1239|Firmicutes,25E8A@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
CMS1_k127_2899173_1	658086.HMPREF0994_05318	4.476e-114	375.0	COG1957@1|root,COG1957@2|Bacteria,1UG03@1239|Firmicutes,24CXS@186801|Clostridia,27R6T@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Inosine-uridine preferring nucleoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	IU_nuc_hydro
CMS1_k127_2899173_5	573413.Spirs_2166	1.808e-05	52.0	COG1476@1|root,COG1476@2|Bacteria,2J97U@203691|Spirochaetes	203691|Spirochaetes	K	helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Phage_CI_repr
CMS1_k127_2901196_5	158190.SpiGrapes_3187	2.111e-122	394.0	COG0263@1|root,COG0263@2|Bacteria,2J6GB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
CMS1_k127_2901196_2	158190.SpiGrapes_3186	1.613e-212	666.0	COG0014@1|root,COG0014@2|Bacteria,2J5JS@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS1_k127_2901196_4	158190.SpiGrapes_3185	3.487e-178	564.0	COG0614@1|root,COG0614@2|Bacteria,2J66K@203691|Spirochaetes	203691|Spirochaetes	P	periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS1_k127_2901196_3	158190.SpiGrapes_3184	2.213e-184	580.0	COG0609@1|root,COG0609@2|Bacteria,2J669@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
CMS1_k127_2901196_6	158190.SpiGrapes_3183	2.503e-118	389.0	COG1120@1|root,COG1120@2|Bacteria,2J5UM@203691|Spirochaetes	203691|Spirochaetes	HP	COGs COG1120 ABC-type cobalamin Fe3 -siderophores transport systems ATPase components	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS1_k127_2901196_0	158190.SpiGrapes_3182	6.827e-320	985.0	COG1001@1|root,COG1001@2|Bacteria,2J5Y3@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
CMS1_k127_2901196_1	158190.SpiGrapes_3181	1.852e-238	741.0	COG2252@1|root,COG2252@2|Bacteria,2J59V@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Xanthine uracil vitamin C permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
CMS1_k127_2903992_1	573413.Spirs_0994	7.241e-109	358.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS1_k127_2903992_2	742733.HMPREF9469_05178	1.318e-57	207.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,25BVS@186801|Clostridia	186801|Clostridia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_2903992_0	1408322.JHYK01000027_gene143	3.381e-114	388.0	COG4584@1|root,COG4584@2|Bacteria,1TNY9@1239|Firmicutes,24B59@186801|Clostridia,27K5P@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS1_k127_2903992_3	1280696.ATVY01000068_gene2487	5.429e-32	136.0	COG1484@1|root,COG1484@2|Bacteria,1TQBX@1239|Firmicutes,249T2@186801|Clostridia,4C20Q@830|Butyrivibrio	186801|Clostridia	L	IstB-like ATP binding N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
CMS1_k127_2903992_4	1056820.KB900633_gene2010	2.291e-09	59.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66
CMS1_k127_2918425_0	158190.SpiGrapes_0300	8.343e-177	557.0	COG0673@1|root,COG0673@2|Bacteria,2J5CU@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS1_k127_2918425_4	158190.SpiGrapes_0299	3.701e-77	260.0	COG4702@1|root,COG4702@2|Bacteria,2J80C@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0303 family	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
CMS1_k127_2918425_3	158190.SpiGrapes_0298	7.596e-88	293.0	COG1437@1|root,COG1437@2|Bacteria,2J8S7@203691|Spirochaetes	203691|Spirochaetes	F	CYTH domain	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
CMS1_k127_2918425_1	158190.SpiGrapes_0297	9.017e-137	438.0	2BZW8@1|root,32R5W@2|Bacteria,2J6GZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2918425_5	158190.SpiGrapes_0296	3.075e-40	149.0	COG3478@1|root,COG3478@2|Bacteria,2JB4S@203691|Spirochaetes	203691|Spirochaetes	S	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)	-	-	-	ko:K07069	-	-	-	-	ko00000	-	-	-	zinc_ribbon_13
CMS1_k127_2935939_2	158190.SpiGrapes_1186	1.626e-40	152.0	COG1917@1|root,COG1917@2|Bacteria,2J9AY@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS1_k127_2935939_0	158190.SpiGrapes_1185	1.099e-299	925.0	COG0369@1|root,COG1151@2|Bacteria,2J5J3@203691|Spirochaetes	203691|Spirochaetes	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	DUF1858,Prismane
CMS1_k127_2935939_1	158189.SpiBuddy_0827	2.269e-56	201.0	COG4225@1|root,COG4225@2|Bacteria	2|Bacteria	S	unsaturated chondroitin disaccharide hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
CMS1_k127_2967767_1	158189.SpiBuddy_0857	6.216e-141	454.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase
CMS1_k127_2967767_0	158189.SpiBuddy_0856	3.138e-200	639.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
CMS1_k127_2967767_2	693746.OBV_39020	2.864e-67	233.0	COG3708@1|root,COG3708@2|Bacteria,1VI4W@1239|Firmicutes,24TUJ@186801|Clostridia	186801|Clostridia	K	Integron-associated effector binding protein	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2
CMS1_k127_2967767_4	748727.CLJU_c27480	1.018e-45	169.0	2AUBE@1|root,31JZ3@2|Bacteria,1V7V1@1239|Firmicutes,24NJE@186801|Clostridia,36KSX@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF3788)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3788
CMS1_k127_2967767_5	1226325.HMPREF1548_05514	2.203e-08	57.0	2CDEH@1|root,32RXK@2|Bacteria,1VA17@1239|Firmicutes,24MPR@186801|Clostridia,36MRJ@31979|Clostridiaceae	186801|Clostridia	S	Maff2 family	-	-	-	-	-	-	-	-	-	-	-	-	Maff2
CMS1_k127_2967767_6	1280390.CBQR020000031_gene693	0.0003314	43.0	COG1309@1|root,COG1309@2|Bacteria,1V2M4@1239|Firmicutes,4HMH5@91061|Bacilli,26WQR@186822|Paenibacillaceae	91061|Bacilli	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
CMS1_k127_2967767_3	931626.Awo_c17190	9.201e-57	201.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS1_k127_2977079_1	158189.SpiBuddy_1854	9.223e-46	169.0	COG5362@1|root,COG5362@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
CMS1_k127_2977079_0	158189.SpiBuddy_2005	3.837e-112	387.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
CMS1_k127_2986048_6	158190.SpiGrapes_2745	9.977e-43	158.0	COG0451@1|root,COG0451@2|Bacteria,2J62J@203691|Spirochaetes	203691|Spirochaetes	M	NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS1_k127_2986048_5	158190.SpiGrapes_2744	1.001e-115	376.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,2J98A@203691|Spirochaetes	203691|Spirochaetes	K	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
CMS1_k127_2986048_2	158190.SpiGrapes_2743	1.174e-261	810.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
CMS1_k127_2986048_3	158190.SpiGrapes_2742	3.835e-207	646.0	COG0216@1|root,COG0216@2|Bacteria,2J5KY@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS1_k127_2986048_4	158190.SpiGrapes_2741	5.9e-120	392.0	COG2890@1|root,COG2890@2|Bacteria,2J7VJ@203691|Spirochaetes	203691|Spirochaetes	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
CMS1_k127_2986048_0	158190.SpiGrapes_2740	0.0	1267.0	COG0317@1|root,COG0317@2|Bacteria,2J5JE@203691|Spirochaetes	203691|Spirochaetes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
CMS1_k127_2986048_1	158190.SpiGrapes_2739	7.071e-316	971.0	COG1227@1|root,COG1227@2|Bacteria,2J6FG@203691|Spirochaetes	203691|Spirochaetes	C	COGs COG1227 Inorganic pyrophosphatase exopolyphosphatase	-	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
CMS1_k127_2986048_7	411902.CLOBOL_05503	1.638e-30	126.0	COG1802@1|root,COG1802@2|Bacteria,1V6NV@1239|Firmicutes,24KBH@186801|Clostridia,220VG@1506553|Lachnoclostridium	186801|Clostridia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_2992542_2	158190.SpiGrapes_0393	1.77e-88	293.0	COG0691@1|root,COG0691@2|Bacteria,2J78Q@203691|Spirochaetes	203691|Spirochaetes	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
CMS1_k127_2992542_0	158190.SpiGrapes_0394	8.882e-212	668.0	COG1262@1|root,COG1262@2|Bacteria,2J67Z@203691|Spirochaetes	203691|Spirochaetes	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
CMS1_k127_2992542_1	158190.SpiGrapes_0395	2.062e-185	592.0	COG0681@1|root,COG0681@2|Bacteria,2J6RU@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the peptidase S26 family	lepB-2	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
CMS1_k127_2992542_3	158190.SpiGrapes_0396	1.617e-08	55.0	COG0635@1|root,COG0635@2|Bacteria,2J5R4@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS1_k127_2994350_0	158190.SpiGrapes_0834	1.497e-246	764.0	COG1882@1|root,COG1882@2|Bacteria,2J62Y@203691|Spirochaetes	203691|Spirochaetes	C	formate acetyltransferase	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
CMS1_k127_2994350_1	158190.SpiGrapes_0835	3.688e-127	407.0	COG1180@1|root,COG1180@2|Bacteria,2J5BK@203691|Spirochaetes	203691|Spirochaetes	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_3011897_1	158190.SpiGrapes_2895	1.498e-208	650.0	COG3437@1|root,COG3437@2|Bacteria,2J7TZ@203691|Spirochaetes	203691|Spirochaetes	T	response regulator	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
CMS1_k127_3011897_0	158190.SpiGrapes_2894	0.0	1748.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,2JBGS@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,NUDIX,PAS_4,Response_reg
CMS1_k127_3011897_2	211114.JOEF01000016_gene3738	3.704e-81	287.0	COG1653@1|root,COG1653@2|Bacteria,2GNRD@201174|Actinobacteria,4DXEG@85010|Pseudonocardiales	201174|Actinobacteria	G	ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_3011897_4	158189.SpiBuddy_2376	3.133e-23	102.0	COG3677@1|root,COG3677@2|Bacteria,2J9IE@203691|Spirochaetes	203691|Spirochaetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595
CMS1_k127_3011897_5	158189.SpiBuddy_2376	2.579e-20	91.0	COG3677@1|root,COG3677@2|Bacteria,2J9IE@203691|Spirochaetes	203691|Spirochaetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595
CMS1_k127_3011897_6	158189.SpiBuddy_2376	1.546e-17	84.0	COG3677@1|root,COG3677@2|Bacteria,2J9IE@203691|Spirochaetes	203691|Spirochaetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595
CMS1_k127_3011897_3	689781.AUJX01000030_gene72	4.112e-33	132.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,247UH@186801|Clostridia,2PR51@265975|Oribacterium	186801|Clostridia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
CMS1_k127_3027971_2	158190.SpiGrapes_0731	1.93e-20	93.0	COG1139@1|root,COG1139@2|Bacteria,2J8P7@203691|Spirochaetes	203691|Spirochaetes	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
CMS1_k127_3027971_0	158190.SpiGrapes_0730	8.064e-314	967.0	COG1236@1|root,COG1236@2|Bacteria,2J5BR@203691|Spirochaetes	203691|Spirochaetes	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
CMS1_k127_3027971_1	158190.SpiGrapes_0729	3.252e-96	319.0	COG0454@1|root,COG0456@2|Bacteria,2J8BV@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_3035728_0	1536774.H70357_35050	1.823e-104	342.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_3035728_1	675814.VIC_003456	8.731e-33	130.0	COG0645@1|root,COG0645@2|Bacteria,1RHF4@1224|Proteobacteria,1S3QW@1236|Gammaproteobacteria,1XXP6@135623|Vibrionales	135623|Vibrionales	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
CMS1_k127_3045364_0	158190.SpiGrapes_0352	2.404e-299	921.0	COG0178@1|root,COG0178@2|Bacteria,2J5BN@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS1_k127_3045364_1	760011.Spico_0464	1.311e-132	432.0	COG0821@1|root,COG0821@2|Bacteria,2J5UT@203691|Spirochaetes	203691|Spirochaetes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
CMS1_k127_3046542_0	1125699.HMPREF9194_00902	5.159e-150	479.0	COG1653@1|root,COG1653@2|Bacteria,2JAFM@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
CMS1_k127_3046542_1	1125699.HMPREF9194_00901	3.428e-117	391.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
CMS1_k127_3046542_2	158190.SpiGrapes_3083	9.803e-90	303.0	2C3WU@1|root,303AS@2|Bacteria,2J9BY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	ko:K16905	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	-
CMS1_k127_3046542_3	158190.SpiGrapes_3084	4.948e-70	240.0	COG1668@1|root,COG1668@2|Bacteria,2J992@203691|Spirochaetes	203691|Spirochaetes	CP	transmembrane transport	-	-	-	ko:K16906	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	-
CMS1_k127_3070008_0	158190.SpiGrapes_0137	3.141e-211	662.0	COG1078@1|root,COG1078@2|Bacteria,2J64T@203691|Spirochaetes	203691|Spirochaetes	S	HD superfamily phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS1_k127_3115084_5	158190.SpiGrapes_0779	4.804e-166	524.0	COG0004@1|root,COG0347@1|root,COG0004@2|Bacteria,COG0347@2|Bacteria,2J5W4@203691|Spirochaetes	203691|Spirochaetes	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
CMS1_k127_3115084_2	158190.SpiGrapes_0781	4.016e-223	693.0	COG2309@1|root,COG2309@2|Bacteria,2J6N5@203691|Spirochaetes	203691|Spirochaetes	E	Leucyl aminopeptidase (Aminopeptidase T)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
CMS1_k127_3115084_7	158190.SpiGrapes_0782	4.099e-138	441.0	COG0564@1|root,COG0564@2|Bacteria,2J82Z@203691|Spirochaetes	203691|Spirochaetes	J	Pseudouridine synthase	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
CMS1_k127_3115084_4	158190.SpiGrapes_0783	5.043e-187	587.0	COG2172@1|root,COG2524@1|root,COG2172@2|Bacteria,COG2524@2|Bacteria,2J63A@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c
CMS1_k127_3115084_12	889378.Spiaf_2400	1.661e-23	104.0	COG4109@1|root,COG4109@2|Bacteria	2|Bacteria	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
CMS1_k127_3115084_8	158190.SpiGrapes_0785	2.45e-128	412.0	COG0613@1|root,COG0613@2|Bacteria,2J7WK@203691|Spirochaetes	203691|Spirochaetes	S	PFAM PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP,PHP_C
CMS1_k127_3115084_9	158190.SpiGrapes_0787	1.785e-125	405.0	COG0670@1|root,COG0670@2|Bacteria,2J7GY@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
CMS1_k127_3115084_6	1173020.Cha6605_5546	4.839e-151	492.0	COG0017@1|root,COG0017@2|Bacteria,1G015@1117|Cyanobacteria	1117|Cyanobacteria	J	PFAM tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS1_k127_3115084_0	158190.SpiGrapes_0790	0.0	1195.0	COG2256@1|root,COG2256@2|Bacteria,2J604@203691|Spirochaetes	203691|Spirochaetes	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
CMS1_k127_3115084_15	1449336.JQLO01000001_gene344	5.738e-05	49.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3115084_1	158190.SpiGrapes_0796	1.392e-249	776.0	COG0544@1|root,COG0544@2|Bacteria,2J5FS@203691|Spirochaetes	203691|Spirochaetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
CMS1_k127_3115084_10	158190.SpiGrapes_0797	4.092e-120	387.0	COG0740@1|root,COG0740@2|Bacteria,2J5VY@203691|Spirochaetes	203691|Spirochaetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS1_k127_3115084_3	158190.SpiGrapes_0798	3.658e-201	627.0	COG1219@1|root,COG1219@2|Bacteria,2J5FF@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS1_k127_3118374_8	1125725.HMPREF1325_1372	4.708e-128	417.0	COG1609@1|root,COG1609@2|Bacteria,2J6Q3@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	scrR	-	-	ko:K02529,ko:K03484	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_3118374_3	158190.SpiGrapes_0568	8.717e-170	537.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	yvdE	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_3118374_0	158190.SpiGrapes_0569	6.494e-253	783.0	COG1653@1|root,COG1653@2|Bacteria,2J5JD@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
CMS1_k127_3118374_4	158190.SpiGrapes_0570	2.958e-166	526.0	COG1175@1|root,COG1175@2|Bacteria,2J6AN@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_3118374_9	665956.HMPREF1032_03526	5.131e-122	397.0	COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia,3WH4R@541000|Ruminococcaceae	186801|Clostridia	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_3118374_1	158190.SpiGrapes_0572	1.638e-249	773.0	COG5520@1|root,COG5520@2|Bacteria,2J6G5@203691|Spirochaetes	2|Bacteria	M	Belongs to the glycosyl hydrolase 30 family	srfJ1	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	Glyco_hydro_30,Glyco_hydro_30C
CMS1_k127_3118374_2	158190.SpiGrapes_0573	6.476e-226	706.0	COG5520@1|root,COG5520@2|Bacteria,2J6G5@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	Glyco_hydro_30,Glyco_hydro_30C
CMS1_k127_3118374_11	158190.SpiGrapes_0567	1.612e-105	351.0	COG1957@1|root,COG1957@2|Bacteria,2J5H3@203691|Spirochaetes	2|Bacteria	F	PFAM Inosine-uridine preferring nucleoside hydrolase	iunH2	-	3.2.2.1,3.2.2.8	ko:K01239,ko:K10213	ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100	-	R01245,R01273,R01677,R01770,R02137,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
CMS1_k127_3118374_6	1298920.KI911353_gene151	1.185e-131	428.0	COG2820@1|root,COG2820@2|Bacteria,1V0U7@1239|Firmicutes,24D1R@186801|Clostridia,21ZBT@1506553|Lachnoclostridium	186801|Clostridia	F	Phosphorylase superfamily	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CMS1_k127_3118374_7	742733.HMPREF9469_03805	1.392e-129	420.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,21ZN7@1506553|Lachnoclostridium	186801|Clostridia	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_3118374_5	742733.HMPREF9469_03804	8.507e-140	452.0	COG4603@1|root,COG4603@2|Bacteria,1UNT4@1239|Firmicutes,24CQN@186801|Clostridia,21YJ2@1506553|Lachnoclostridium	186801|Clostridia	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_3118374_10	457421.CBFG_02743	1.234e-115	381.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,26845@186813|unclassified Clostridiales	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_3155448_0	1536774.H70357_35045	3.206e-88	301.0	COG3595@1|root,COG3595@2|Bacteria,1VKFR@1239|Firmicutes	1239|Firmicutes	S	Putative adhesin	-	-	-	ko:K11621	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF1700,DUF4097
CMS1_k127_3155448_1	351627.Csac_2550	3.611e-42	172.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TSRP@1239|Firmicutes,24CRG@186801|Clostridia	186801|Clostridia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
CMS1_k127_3175421_1	760011.Spico_1283	3.849e-58	204.0	COG4225@1|root,COG4225@2|Bacteria	2|Bacteria	S	unsaturated chondroitin disaccharide hydrolase activity	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
CMS1_k127_3175421_0	665956.HMPREF1032_02351	1.055e-283	903.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia,3WHH3@541000|Ruminococcaceae	186801|Clostridia	G	PFAM Glycosyl hydrolases family 38 C-terminal domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
CMS1_k127_322691_10	158190.SpiGrapes_0034	2.862e-105	344.0	COG0177@1|root,COG0177@2|Bacteria,2J84F@203691|Spirochaetes	203691|Spirochaetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CMS1_k127_322691_15	158190.SpiGrapes_0036	2.33e-42	155.0	COG0227@1|root,COG0227@2|Bacteria,2J99Q@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
CMS1_k127_322691_0	158190.SpiGrapes_0037	0.0	1330.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,2J5C6@203691|Spirochaetes	203691|Spirochaetes	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
CMS1_k127_322691_1	158190.SpiGrapes_0038	1.818e-245	762.0	COG0498@1|root,COG0498@2|Bacteria,2J63T@203691|Spirochaetes	203691|Spirochaetes	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
CMS1_k127_322691_11	158190.SpiGrapes_0039	2.917e-99	332.0	COG2014@1|root,COG2014@2|Bacteria,2JAGM@203691|Spirochaetes	203691|Spirochaetes	S	Putative heavy-metal chelation	-	-	-	ko:K09138	-	-	-	-	ko00000	-	-	-	DUF364,DUF4213
CMS1_k127_322691_4	158190.SpiGrapes_0040	9.008e-218	681.0	COG0153@1|root,COG0153@2|Bacteria,2J5D6@203691|Spirochaetes	203691|Spirochaetes	H	GHMP kinase	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_N,GalKase_gal_bdg
CMS1_k127_322691_5	158190.SpiGrapes_0041	1.354e-188	593.0	COG1085@1|root,COG1085@2|Bacteria,2J5XJ@203691|Spirochaetes	203691|Spirochaetes	H	galactose-1-phosphate uridylyltransferase	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
CMS1_k127_322691_7	158190.SpiGrapes_0042	5.596e-146	469.0	COG1609@1|root,COG1609@2|Bacteria,2JAHE@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI
CMS1_k127_322691_14	158190.SpiGrapes_0043	7.682e-43	159.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
CMS1_k127_322691_2	1123274.KB899412_gene1424	3.8e-241	751.0	COG1486@1|root,COG1486@2|Bacteria,2J688@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
CMS1_k127_322691_13	1480694.DC28_08700	2.039e-45	178.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_322691_3	158190.SpiGrapes_0046	2.667e-224	706.0	COG0514@1|root,COG0514@2|Bacteria,2J5BY@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
CMS1_k127_322691_9	158190.SpiGrapes_0047	1.648e-114	374.0	COG3279@1|root,COG3279@2|Bacteria,2J99H@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
CMS1_k127_322691_6	158190.SpiGrapes_0048	1.103e-180	574.0	COG3290@1|root,COG3290@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HATPase_c_5,PAS_9
CMS1_k127_322691_8	158190.SpiGrapes_0050	5.7e-121	411.0	COG3210@1|root,COG3391@1|root,COG3210@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,HYR,Haemagg_act,Hint_2
CMS1_k127_3243239_0	573413.Spirs_0777	6.015e-275	851.0	COG3333@1|root,COG3333@2|Bacteria,2J70X@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
CMS1_k127_3243239_1	1123274.KB899420_gene4026	8.896e-39	150.0	COG0537@1|root,COG0537@2|Bacteria,2JB1S@203691|Spirochaetes	203691|Spirochaetes	FG	adenosine 5'-monophosphoramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3244486_0	1511.CLOST_1006	9.728e-111	370.0	COG0683@1|root,COG0683@2|Bacteria,1UHWZ@1239|Firmicutes,25E5X@186801|Clostridia	186801|Clostridia	E	Protein of unknown function (DUF3798)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3798
CMS1_k127_3244486_1	1123009.AUID01000002_gene2108	6.164e-45	167.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,269ZV@186813|unclassified Clostridiales	186801|Clostridia	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_3253852_2	158190.SpiGrapes_0369	7.471e-94	310.0	2FKFF@1|root,34C2R@2|Bacteria,2J7SF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3253852_1	158190.SpiGrapes_0370	9.221e-151	483.0	COG0190@1|root,COG0190@2|Bacteria,2J5PR@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
CMS1_k127_3253852_0	158190.SpiGrapes_0371	8.607e-215	670.0	COG0621@1|root,COG0621@2|Bacteria,2J5GF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CMS1_k127_3283296_0	158189.SpiBuddy_2046	3.881e-155	496.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	bvdR	-	1.3.1.24	ko:K00214	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R02391,R02393	RC01983	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA
CMS1_k127_3310801_0	158189.SpiBuddy_0827	5.649e-193	616.0	COG4225@1|root,COG4225@2|Bacteria	2|Bacteria	S	unsaturated chondroitin disaccharide hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
CMS1_k127_3310801_1	768706.Desor_2742	1.876e-60	214.0	COG0500@1|root,COG0500@2|Bacteria,1V0PR@1239|Firmicutes,25E3Q@186801|Clostridia,265DE@186807|Peptococcaceae	186801|Clostridia	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS1_k127_3315800_10	158189.SpiBuddy_2303	4.083e-22	96.0	COG2195@1|root,COG2195@2|Bacteria,2J59I@203691|Spirochaetes	203691|Spirochaetes	E	Cleaves the N-terminal amino acid of tripeptides	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
CMS1_k127_3315800_4	158190.SpiGrapes_1827	1.085e-108	362.0	2BHII@1|root,32BKY@2|Bacteria,2JB5E@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3315800_0	158190.SpiGrapes_1820	0.0	1230.0	COG1208@1|root,COG1208@2|Bacteria,2J5V0@203691|Spirochaetes	203691|Spirochaetes	JM	Domain of unknown function (DUF4954)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954
CMS1_k127_3315800_7	158190.SpiGrapes_1819	2.081e-57	204.0	2E9V0@1|root,3340V@2|Bacteria	2|Bacteria	S	carotenoid biosynthetic process	crtO	-	-	ko:K10212	ko00906,map00906	-	R07656	RC00041	ko00000,ko00001,ko01000	-	-	-	-
CMS1_k127_3315800_5	158190.SpiGrapes_1818	1.257e-101	340.0	COG0604@1|root,COG0604@2|Bacteria,2JB29@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3315800_9	158189.SpiBuddy_0104	1.049e-35	139.0	COG1695@1|root,COG1695@2|Bacteria,2J937@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS1_k127_3315800_1	158190.SpiGrapes_1815	0.0	1000.0	COG0504@1|root,COG0504@2|Bacteria,2J5AB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
CMS1_k127_3315800_6	158190.SpiGrapes_1814	2.53e-100	330.0	COG3707@1|root,COG3707@2|Bacteria,2J8PK@203691|Spirochaetes	203691|Spirochaetes	K	ANTAR domain protein	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
CMS1_k127_3315800_2	158190.SpiGrapes_1813	4.495e-251	778.0	COG0174@1|root,COG0174@2|Bacteria,2J6JS@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
CMS1_k127_3315800_3	158190.SpiGrapes_1812	1.838e-140	450.0	COG0070@1|root,COG0070@2|Bacteria,2J7N9@203691|Spirochaetes	203691|Spirochaetes	E	PFAM glutamate synthase alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
CMS1_k127_3315800_8	158190.SpiGrapes_1811	3.201e-53	188.0	COG1251@1|root,COG1251@2|Bacteria,2J81W@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
CMS1_k127_3356128_16	158190.SpiGrapes_1139	4.304e-111	364.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS1_k127_3356128_10	158190.SpiGrapes_1140	3.052e-157	504.0	COG2038@1|root,COG2038@2|Bacteria,2J7KE@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
CMS1_k127_3356128_17	158189.SpiBuddy_0882	8.475e-102	340.0	COG3238@1|root,COG3238@2|Bacteria	2|Bacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
CMS1_k127_3356128_12	158190.SpiGrapes_1142	2.399e-151	482.0	COG1194@1|root,COG1194@2|Bacteria,2J5B8@203691|Spirochaetes	203691|Spirochaetes	L	A G-specific	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
CMS1_k127_3356128_3	158190.SpiGrapes_1143	3.06e-223	697.0	COG0628@1|root,COG0628@2|Bacteria,2J596@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS1_k127_3356128_19	760011.Spico_0286	2.993e-89	301.0	COG0565@1|root,COG0565@2|Bacteria,2J6NV@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CMS1_k127_3356128_13	158190.SpiGrapes_1145	9.453e-144	458.0	COG0584@1|root,COG0584@2|Bacteria,2J689@203691|Spirochaetes	203691|Spirochaetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS1_k127_3356128_4	158190.SpiGrapes_1146	2.17e-220	688.0	COG2768@1|root,COG2768@2|Bacteria,2J5VC@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
CMS1_k127_3356128_15	1280390.CBQR020000100_gene2320	1.629e-114	377.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,274FR@186822|Paenibacillaceae	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
CMS1_k127_3356128_11	158190.SpiGrapes_1147	2.334e-152	486.0	COG0363@1|root,COG0363@2|Bacteria,2J597@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion	nagB	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
CMS1_k127_3356128_6	158190.SpiGrapes_1148	9.215e-203	634.0	COG0482@1|root,COG0482@2|Bacteria,2J6BI@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS1_k127_3356128_0	158190.SpiGrapes_1151	0.0	1375.0	COG1529@1|root,COG1529@2|Bacteria,2J70V@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS1_k127_3356128_9	158190.SpiGrapes_1152	6.79e-163	516.0	COG1319@1|root,COG1319@2|Bacteria,2J65V@203691|Spirochaetes	203691|Spirochaetes	C	Molybdopterin dehydrogenase	-	-	1.17.1.4	ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
CMS1_k127_3356128_20	861454.HMPREF9099_00123	3.394e-65	227.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24FZI@186801|Clostridia,27M8K@186928|unclassified Lachnospiraceae	186801|Clostridia	C	[2Fe-2S] binding domain	cutS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS1_k127_3356128_14	158190.SpiGrapes_1154	8.743e-132	425.0	COG0671@1|root,COG0671@2|Bacteria,2J7YV@203691|Spirochaetes	203691|Spirochaetes	I	Membrane-associated phospholipid phosphatase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
CMS1_k127_3356128_21	877418.ATWV01000005_gene2536	1.184e-35	143.0	COG0847@1|root,COG0847@2|Bacteria,2J98Y@203691|Spirochaetes	203691|Spirochaetes	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
CMS1_k127_3356128_5	158190.SpiGrapes_1156	7.169e-208	653.0	COG3681@1|root,COG3681@2|Bacteria,2J6AS@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0597 family	-	-	-	-	-	-	-	-	-	-	-	-	SDH_alpha
CMS1_k127_3356128_2	158190.SpiGrapes_1157	5.831e-225	704.0	COG1482@1|root,COG1482@2|Bacteria,2J6VI@203691|Spirochaetes	203691|Spirochaetes	G	mannose-6-phosphate isomerase, class I	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
CMS1_k127_3356128_8	158190.SpiGrapes_1159	2.388e-172	553.0	COG1073@1|root,COG1506@1|root,COG1073@2|Bacteria,COG1506@2|Bacteria,2J5GE@203691|Spirochaetes	203691|Spirochaetes	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
CMS1_k127_3356128_7	158190.SpiGrapes_1160	7.226e-182	577.0	2DRY6@1|root,33DN5@2|Bacteria,2JB74@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3356128_1	158190.SpiGrapes_1162	0.0	1031.0	COG1022@1|root,COG1022@2|Bacteria,2J9S5@203691|Spirochaetes	203691|Spirochaetes	I	Long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
CMS1_k127_3357469_2	158190.SpiGrapes_3145	8.345e-194	606.0	COG0031@1|root,COG0031@2|Bacteria,2J9V1@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
CMS1_k127_3357469_1	158190.SpiGrapes_3144	8.548e-239	741.0	COG0498@1|root,COG0498@2|Bacteria,2J84W@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS1_k127_3357469_0	158190.SpiGrapes_3142	6.235e-281	867.0	COG1653@1|root,COG1653@2|Bacteria,2J7U7@203691|Spirochaetes	203691|Spirochaetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
CMS1_k127_3357469_4	158190.SpiGrapes_3141	2.073e-154	493.0	COG0395@1|root,COG0395@2|Bacteria,2J7F3@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
CMS1_k127_3357469_3	158190.SpiGrapes_3140	2.52e-163	517.0	COG1175@1|root,COG1175@2|Bacteria,2J5TH@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
CMS1_k127_3369754_6	158190.SpiGrapes_2915	1.126e-130	420.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_3369754_1	158190.SpiGrapes_2916	2.021e-241	753.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
CMS1_k127_3369754_3	158190.SpiGrapes_2917	3.362e-209	657.0	COG4591@1|root,COG4591@2|Bacteria,2J6KF@203691|Spirochaetes	203691|Spirochaetes	M	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS1_k127_3369754_7	158190.SpiGrapes_2918	5.837e-127	409.0	COG2834@1|root,COG2834@2|Bacteria,2J5TZ@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS1_k127_3369754_5	158190.SpiGrapes_2919	9.929e-151	486.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3369754_8	158190.SpiGrapes_2920	4.498e-111	364.0	COG0745@1|root,COG0745@2|Bacteria,2J7CF@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_3369754_4	158190.SpiGrapes_2921	6.093e-164	527.0	COG0642@1|root,COG0642@2|Bacteria	2|Bacteria	T	Histidine kinase	cssS	-	2.7.13.3	ko:K07641,ko:K07650	ko02020,map02020	M00448,M00449	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS1_k127_3369754_0	158190.SpiGrapes_2922	7.006e-273	841.0	COG0462@1|root,COG0462@2|Bacteria,2J5IY@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
CMS1_k127_3369754_2	158190.SpiGrapes_2923	1.77e-239	743.0	COG0436@1|root,COG0436@2|Bacteria,2J6V4@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Aminotransferase class I and II	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_3369754_11	158190.SpiGrapes_0198	2.776e-14	77.0	COG1905@1|root,COG1905@2|Bacteria,2J8R3@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS1_k127_3382581_7	158190.SpiGrapes_0418	1.115e-121	391.0	COG0343@1|root,COG0343@2|Bacteria,2J5U0@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CMS1_k127_3382581_4	158190.SpiGrapes_0417	1.282e-163	524.0	COG0795@1|root,COG0795@2|Bacteria,2J64B@203691|Spirochaetes	203691|Spirochaetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
CMS1_k127_3382581_3	158190.SpiGrapes_0416	3.685e-186	589.0	COG0795@1|root,COG0795@2|Bacteria,2J5F9@203691|Spirochaetes	203691|Spirochaetes	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
CMS1_k127_3382581_8	158190.SpiGrapes_0415	2.352e-70	240.0	COG0756@1|root,COG0756@2|Bacteria,2J7JH@203691|Spirochaetes	203691|Spirochaetes	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
CMS1_k127_3382581_1	158190.SpiGrapes_0414	0.0	1273.0	COG1185@1|root,COG1185@2|Bacteria,2J5BU@203691|Spirochaetes	203691|Spirochaetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
CMS1_k127_3382581_9	158190.SpiGrapes_0413	1.444e-44	162.0	COG0184@1|root,COG0184@2|Bacteria,2J91K@203691|Spirochaetes	203691|Spirochaetes	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
CMS1_k127_3382581_6	158190.SpiGrapes_0412	2.834e-150	478.0	COG0196@1|root,COG0196@2|Bacteria,2J7F1@203691|Spirochaetes	203691|Spirochaetes	H	riboflavin biosynthesis protein	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
CMS1_k127_3382581_5	158190.SpiGrapes_0411	9.801e-158	501.0	COG0130@1|root,COG0130@2|Bacteria,2J7Q2@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
CMS1_k127_3382581_10	760011.Spico_0595	1.373e-34	136.0	COG0858@1|root,COG0858@2|Bacteria,2J82W@203691|Spirochaetes	203691|Spirochaetes	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
CMS1_k127_3382581_0	158189.SpiBuddy_1395	0.0	1341.0	COG0532@1|root,COG0532@2|Bacteria,2J692@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
CMS1_k127_3382581_2	158190.SpiGrapes_0408	2.078e-297	916.0	COG0195@1|root,COG0195@2|Bacteria,2J624@203691|Spirochaetes	203691|Spirochaetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1,zf-ribbon_3
CMS1_k127_3396745_6	469618.FVAG_00611	1.509e-07	57.0	COG0438@1|root,COG0438@2|Bacteria,37B7Q@32066|Fusobacteria	32066|Fusobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS1_k127_3396745_2	158190.SpiGrapes_1568	1.734e-160	512.0	COG0451@1|root,COG0451@2|Bacteria,2J8W6@203691|Spirochaetes	203691|Spirochaetes	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS1_k127_3396745_3	158190.SpiGrapes_1569	4.852e-141	450.0	COG1211@1|root,COG1211@2|Bacteria,2J8HC@203691|Spirochaetes	203691|Spirochaetes	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
CMS1_k127_3396745_4	158190.SpiGrapes_1570	1.439e-137	442.0	COG3475@1|root,COG3475@2|Bacteria,2J8GU@203691|Spirochaetes	203691|Spirochaetes	M	LicD family	-	-	-	ko:K07271	-	-	-	-	ko00000,ko01000	-	-	-	LicD
CMS1_k127_3396745_1	545695.TREAZ_0671	5.884e-168	543.0	2DX7Z@1|root,343SE@2|Bacteria,2J5PD@203691|Spirochaetes	203691|Spirochaetes	S	Capsule assembly protein Wzi	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
CMS1_k127_3396745_0	357809.Cphy_1707	5.578e-217	689.0	COG1397@1|root,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,25DA4@186801|Clostridia	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
CMS1_k127_3396745_5	1235792.C808_05147	2.426e-72	246.0	COG0395@1|root,COG0395@2|Bacteria,1U0R6@1239|Firmicutes,248I2@186801|Clostridia,27JXE@186928|unclassified Lachnospiraceae	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_3399302_8	158190.SpiGrapes_1340	2.94e-184	581.0	COG0534@1|root,COG0534@2|Bacteria,2J6QF@203691|Spirochaetes	203691|Spirochaetes	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_3399302_27	158190.SpiGrapes_1342	5.933e-64	224.0	COG1342@1|root,COG1342@2|Bacteria,2J9BU@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function  DUF134	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
CMS1_k127_3399302_28	158190.SpiGrapes_1343	2.789e-55	196.0	COG1433@1|root,COG1433@2|Bacteria,2JBC9@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
CMS1_k127_3399302_20	913865.DOT_1847	2.022e-103	344.0	COG1149@1|root,COG1149@2|Bacteria,1TP7Y@1239|Firmicutes,249ER@186801|Clostridia,260ZC@186807|Peptococcaceae	186801|Clostridia	C	PFAM CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4,Fer4_4
CMS1_k127_3399302_16	158190.SpiGrapes_1345	4.924e-134	433.0	COG1149@1|root,COG1149@2|Bacteria,2JAAI@203691|Spirochaetes	203691|Spirochaetes	C	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4,Fer4_4
CMS1_k127_3399302_17	158190.SpiGrapes_1346	5.77e-120	391.0	COG1237@1|root,COG1237@2|Bacteria,2J79D@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS1_k127_3399302_4	158190.SpiGrapes_1347	8.148e-227	707.0	COG0489@1|root,COG1433@1|root,COG0489@2|Bacteria,COG1433@2|Bacteria,2J573@203691|Spirochaetes	203691|Spirochaetes	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	ParA
CMS1_k127_3399302_23	760011.Spico_1759	2.502e-91	312.0	COG2207@1|root,COG2207@2|Bacteria,2J75A@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS1_k127_3399302_30	1410622.JNKY01000010_gene1176	2.512e-33	135.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,27ITZ@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Aminotransferase class-V	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
CMS1_k127_3399302_9	760011.Spico_1761	5.03e-176	559.0	COG0520@1|root,COG0520@2|Bacteria,2J61S@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K04487,ko:K11717	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03599,R07460,R11528,R11529	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS1_k127_3399302_22	760011.Spico_1762	1.435e-97	331.0	COG0719@1|root,COG0719@2|Bacteria,2J5WQ@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
CMS1_k127_3399302_3	760011.Spico_1763	7.647e-233	730.0	COG0719@1|root,COG0719@2|Bacteria,2J5T1@203691|Spirochaetes	203691|Spirochaetes	O	assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
CMS1_k127_3399302_19	760011.Spico_1764	5.516e-111	365.0	COG0396@1|root,COG0396@2|Bacteria,2J5E0@203691|Spirochaetes	203691|Spirochaetes	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
CMS1_k127_3399302_15	158190.SpiGrapes_1348	1.205e-138	447.0	COG1387@1|root,COG1387@2|Bacteria,2J85Q@203691|Spirochaetes	203691|Spirochaetes	E	histidinol phosphate phosphatase	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
CMS1_k127_3399302_5	158190.SpiGrapes_1356	3.245e-222	692.0	COG0687@1|root,COG0687@2|Bacteria,2J5D5@203691|Spirochaetes	203691|Spirochaetes	P	Spermidine putrescine-binding periplasmic protein	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
CMS1_k127_3399302_0	158190.SpiGrapes_1357	5.878e-268	830.0	COG0015@1|root,COG0015@2|Bacteria,2J60J@203691|Spirochaetes	203691|Spirochaetes	F	Adenylosuccinate lyase	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
CMS1_k127_3399302_29	1236508.BAKF01000013_gene1298	2.58e-38	151.0	2EGCM@1|root,33A4E@2|Bacteria,4NY23@976|Bacteroidetes,2FQIZ@200643|Bacteroidia	976|Bacteroidetes	S	RloB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	RloB
CMS1_k127_3399302_26	667015.Bacsa_1183	5.298e-78	276.0	COG1106@1|root,COG1106@2|Bacteria,4NE5J@976|Bacteroidetes,2FQDP@200643|Bacteroidia,4AP53@815|Bacteroidaceae	976|Bacteroidetes	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K06926	-	-	-	-	ko00000	-	-	-	AAA_21
CMS1_k127_3399302_21	158190.SpiGrapes_1359	3.979e-100	329.0	COG1238@1|root,COG1238@2|Bacteria,2JATD@203691|Spirochaetes	203691|Spirochaetes	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS1_k127_3399302_11	158190.SpiGrapes_1360	3.63e-174	554.0	COG2872@1|root,COG2872@2|Bacteria,2JBG6@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
CMS1_k127_3399302_18	158190.SpiGrapes_1361	2.31e-111	364.0	COG2860@1|root,COG2860@2|Bacteria,2JAIY@203691|Spirochaetes	203691|Spirochaetes	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
CMS1_k127_3399302_25	158190.SpiGrapes_1362	2.29e-81	287.0	2E1WK@1|root,32X5T@2|Bacteria,2J7RT@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3399302_1	158190.SpiGrapes_1363	2.024e-260	804.0	COG0281@1|root,COG0281@2|Bacteria,2J5DN@203691|Spirochaetes	203691|Spirochaetes	C	Malic enzyme, NAD binding domain	mdh	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
CMS1_k127_3399302_2	158190.SpiGrapes_1364	9.498e-247	762.0	COG2055@1|root,COG2055@2|Bacteria,2J5HD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the LDH2 MDH2 oxidoreductase family	yjmC	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
CMS1_k127_3399302_13	158190.SpiGrapes_1365	2.556e-151	480.0	COG1349@1|root,COG1349@2|Bacteria,2JADD@203691|Spirochaetes	203691|Spirochaetes	K	DeoR C terminal sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
CMS1_k127_3399302_14	158190.SpiGrapes_1369	3.254e-139	443.0	COG0410@1|root,COG0410@2|Bacteria,2J5VQ@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
CMS1_k127_3399302_12	158190.SpiGrapes_1370	2.649e-168	530.0	COG0411@1|root,COG0411@2|Bacteria,2J67T@203691|Spirochaetes	203691|Spirochaetes	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
CMS1_k127_3399302_7	158190.SpiGrapes_1371	1.387e-207	649.0	COG4177@1|root,COG4177@2|Bacteria,2J717@203691|Spirochaetes	203691|Spirochaetes	E	transport system permease	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS1_k127_3399302_10	158190.SpiGrapes_1372	2.57e-174	548.0	COG0559@1|root,COG0559@2|Bacteria,2J64W@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS1_k127_3399302_6	158190.SpiGrapes_1373	1.257e-219	687.0	COG0683@1|root,COG0683@2|Bacteria,2J63M@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS1_k127_3408239_12	158190.SpiGrapes_1282	1.047e-76	259.0	COG1846@1|root,COG1846@2|Bacteria,2J7TV@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS1_k127_3408239_0	158190.SpiGrapes_1278	1.71e-251	786.0	2C3NG@1|root,348TB@2|Bacteria,2J5WS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
CMS1_k127_3408239_15	158190.SpiGrapes_1276	1.147e-42	158.0	COG2005@1|root,COG2005@2|Bacteria	2|Bacteria	P	Transcriptional regulator	-	-	-	ko:K02019,ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000,ko03000	3.A.1.6.2,3.A.1.6.4	-	-	HTH_1,NTP_transf_3
CMS1_k127_3408239_2	158190.SpiGrapes_1275	4.867e-180	568.0	COG0303@1|root,COG0303@2|Bacteria,2J6XY@203691|Spirochaetes	203691|Spirochaetes	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
CMS1_k127_3408239_14	158190.SpiGrapes_1274	3.609e-70	240.0	COG0315@1|root,COG0315@2|Bacteria,2J81J@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
CMS1_k127_3408239_6	158190.SpiGrapes_1273	1.998e-127	416.0	COG2896@1|root,COG2896@2|Bacteria,2J7IB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
CMS1_k127_3408239_3	158190.SpiGrapes_1272	1.471e-173	548.0	COG0521@1|root,COG2258@1|root,COG0521@2|Bacteria,COG2258@2|Bacteria,2J80H@203691|Spirochaetes	203691|Spirochaetes	H	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
CMS1_k127_3408239_7	158190.SpiGrapes_1271	1.295e-124	403.0	COG0725@1|root,COG0725@2|Bacteria,2J716@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
CMS1_k127_3408239_13	931276.Cspa_c30670	1.854e-72	252.0	COG4149@1|root,COG4149@2|Bacteria,1TRNA@1239|Firmicutes,24BR9@186801|Clostridia,36FDT@31979|Clostridiaceae	186801|Clostridia	P	molybdate ABC transporter, permease protein	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
CMS1_k127_3408239_10	158190.SpiGrapes_1269	2.134e-100	331.0	COG3842@1|root,COG3842@2|Bacteria,2J7EZ@203691|Spirochaetes	203691|Spirochaetes	E	ABC transporter	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran
CMS1_k127_3408239_4	158190.SpiGrapes_1268	4.439e-172	542.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
CMS1_k127_3408239_9	1123274.KB899416_gene2599	6.101e-108	358.0	COG1131@1|root,COG1131@2|Bacteria,2J5JM@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_3408239_1	158190.SpiGrapes_1266	8.904e-203	638.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase_2,NPCBM,NPCBM_assoc
CMS1_k127_3408239_16	111105.HR09_04230	9.404e-24	106.0	COG1725@1|root,COG1725@2|Bacteria,4NT1X@976|Bacteroidetes,2FTX9@200643|Bacteroidia,22YHZ@171551|Porphyromonadaceae	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GntR
CMS1_k127_3408239_8	158190.SpiGrapes_1263	6.267e-110	362.0	2EFTR@1|root,339JU@2|Bacteria,2JAS7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3408239_5	158190.SpiGrapes_1262	1.283e-151	483.0	COG1131@1|root,COG1131@2|Bacteria,2J7Z5@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_3434541_3	158190.SpiGrapes_2314	1.092e-14	74.0	COG0347@1|root,COG0347@2|Bacteria,2J7GB@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	P-II
CMS1_k127_3434541_0	158190.SpiGrapes_2313	7.958e-272	841.0	COG0589@1|root,COG0589@2|Bacteria,2J5MY@203691|Spirochaetes	203691|Spirochaetes	T	InterPro IPR011435	-	-	-	-	-	-	-	-	-	-	-	-	DUF1538
CMS1_k127_3434541_2	1469948.JPNB01000001_gene908	3.88e-40	157.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_3434541_1	1151292.QEW_0844	2.187e-44	165.0	COG2768@1|root,COG2768@2|Bacteria,1UJH4@1239|Firmicutes,25GGG@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_9,Flavodoxin_5
CMS1_k127_3438480_1	573413.Spirs_3060	6.225e-112	367.0	COG2942@1|root,COG2942@2|Bacteria,2J66W@203691|Spirochaetes	203691|Spirochaetes	G	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	-	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
CMS1_k127_3438480_2	1033734.CAET01000005_gene3750	6.666e-64	225.0	COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,4HH1R@91061|Bacilli,1ZICD@1386|Bacillus	91061|Bacilli	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
CMS1_k127_3438480_0	1125725.HMPREF1325_2154	4.988e-173	549.0	COG1915@1|root,COG1915@2|Bacteria,2J6M0@203691|Spirochaetes	203691|Spirochaetes	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3438480_3	1125725.HMPREF1325_2155	4.899e-58	204.0	COG0524@1|root,COG0546@1|root,COG0524@2|Bacteria,COG0546@2|Bacteria,2JBJS@203691|Spirochaetes	203691|Spirochaetes	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase,PfkB
CMS1_k127_3439276_2	158190.SpiGrapes_0453	2.848e-113	367.0	COG4198@1|root,COG4198@2|Bacteria,2J5EV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
CMS1_k127_3439276_4	158190.SpiGrapes_0454	4.125e-102	334.0	COG0009@1|root,COG0009@2|Bacteria,2J7KX@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the SUA5 family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
CMS1_k127_3439276_5	158189.SpiBuddy_1350	2.664e-30	124.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
CMS1_k127_3439276_0	158190.SpiGrapes_0457	7.502e-182	571.0	COG1234@1|root,COG1234@2|Bacteria,2J6E7@203691|Spirochaetes	203691|Spirochaetes	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
CMS1_k127_3439276_1	158190.SpiGrapes_0458	2.91e-178	565.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	lolE	-	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
CMS1_k127_3466135_2	1122963.AUHB01000004_gene3049	7.275e-59	213.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria	1224|Proteobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
CMS1_k127_3466135_1	1122963.AUHB01000004_gene3048	2.012e-154	498.0	COG1482@1|root,COG1482@2|Bacteria	2|Bacteria	G	cell wall glycoprotein biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
CMS1_k127_3466135_0	158190.SpiGrapes_1495	1.199e-238	743.0	COG2199@1|root,COG2199@2|Bacteria,2JBH5@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_3482653_5	180332.JTGN01000010_gene4507	1.53e-177	560.0	COG1653@1|root,COG1653@2|Bacteria,1UZUY@1239|Firmicutes,24DAQ@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_3482653_10	180332.JTGN01000010_gene4508	2.967e-143	459.0	COG1175@1|root,COG1175@2|Bacteria,1TRGR@1239|Firmicutes,251CI@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_3482653_14	180332.JTGN01000010_gene4509	9.509e-115	376.0	COG0395@1|root,COG0395@2|Bacteria,1V07G@1239|Firmicutes,24A7P@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_3482653_7	180332.JTGN01000005_gene2864	1.115e-164	526.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24E75@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
CMS1_k127_3482653_22	158189.SpiBuddy_2691	9.41e-39	149.0	COG2731@1|root,COG2731@2|Bacteria	2|Bacteria	G	single-species biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF386
CMS1_k127_3482653_16	445972.ANACOL_04251	4.617e-97	327.0	COG0329@1|root,COG0329@2|Bacteria,1V27R@1239|Firmicutes,25CFB@186801|Clostridia	186801|Clostridia	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
CMS1_k127_3482653_13	693746.OBV_39060	4.635e-120	391.0	COG3836@1|root,COG3836@2|Bacteria,1TUKH@1239|Firmicutes,24YCJ@186801|Clostridia,2N8FK@216572|Oscillospiraceae	186801|Clostridia	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS1_k127_3482653_9	1219084.AP014508_gene138	4.036e-150	490.0	COG3333@1|root,COG3333@2|Bacteria,2GDV9@200918|Thermotogae	2|Bacteria	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
CMS1_k127_3482653_17	573413.Spirs_0068	3.158e-86	296.0	COG3181@1|root,COG3181@2|Bacteria,2J7TJ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
CMS1_k127_3482653_23	428125.CLOLEP_02782	7.845e-38	152.0	COG1414@1|root,COG1414@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
CMS1_k127_3482653_1	428125.CLOLEP_02786	6.016e-233	728.0	COG2407@1|root,COG2407@2|Bacteria,1TUBG@1239|Firmicutes,25ASQ@186801|Clostridia,3WR6R@541000|Ruminococcaceae	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3482653_21	1499967.BAYZ01000022_gene219	6.476e-49	179.0	COG0698@1|root,COG0698@2|Bacteria,2NPF4@2323|unclassified Bacteria	2|Bacteria	G	ribose 5-phosphate isomerase B	ywlF_2	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
CMS1_k127_3482653_11	908340.HMPREF9406_0241	1.346e-142	459.0	COG2376@1|root,COG2376@2|Bacteria,1TP92@1239|Firmicutes,2488D@186801|Clostridia,36E0T@31979|Clostridiaceae	186801|Clostridia	G	Dihydroxyacetone kinase DhaK, subunit	-	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1
CMS1_k127_3482653_19	411490.ANACAC_03165	5.138e-66	231.0	COG1461@1|root,COG1461@2|Bacteria,1V4FH@1239|Firmicutes,24FUX@186801|Clostridia	186801|Clostridia	S	Dihydroxyacetone kinase, L subunit	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
CMS1_k127_3482653_26	158189.SpiBuddy_0612	7.539e-10	64.0	COG4467@1|root,COG4467@2|Bacteria	2|Bacteria	L	Involved in initiation control of chromosome replication	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
CMS1_k127_3482653_24	158190.SpiGrapes_2644	2.489e-37	151.0	COG2186@1|root,COG2186@2|Bacteria,2J7JW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_3482653_12	158190.SpiGrapes_1783	2.932e-138	446.0	arCOG10456@1|root,2ZA6T@2|Bacteria,2J8WU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3482653_20	158190.SpiGrapes_1784	1.189e-63	221.0	COG1846@1|root,COG1846@2|Bacteria,2J90G@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS1_k127_3482653_25	889378.Spiaf_1334	2.466e-30	130.0	2EFJZ@1|root,339C8@2|Bacteria,2J6Y9@203691|Spirochaetes	203691|Spirochaetes	S	Predicted periplasmic protein (DUF2271)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2271
CMS1_k127_3482653_0	158190.SpiGrapes_1785	0.0	1118.0	COG0367@1|root,COG0367@2|Bacteria,2J6Q5@203691|Spirochaetes	203691|Spirochaetes	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS1_k127_3482653_2	158190.SpiGrapes_1786	9.036e-220	685.0	COG4992@1|root,COG4992@2|Bacteria,2J5X2@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS1_k127_3482653_6	158190.SpiGrapes_1787	5.949e-168	531.0	COG0548@1|root,COG0548@2|Bacteria,2J6RN@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
CMS1_k127_3482653_3	158190.SpiGrapes_1788	2.974e-210	659.0	COG1364@1|root,COG1364@2|Bacteria,2J5IC@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
CMS1_k127_3482653_4	158190.SpiGrapes_1789	7.471e-188	591.0	COG0002@1|root,COG0002@2|Bacteria,2J5UE@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS1_k127_3482653_18	158190.SpiGrapes_1790	8.234e-83	281.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128,3.6.1.55	ko:K03574,ko:K03789	-	-	-	-	ko00000,ko01000,ko03009,ko03400	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
CMS1_k127_3482653_15	158190.SpiGrapes_1791	4.448e-102	336.0	COG1102@1|root,COG1102@2|Bacteria,2J5C1@203691|Spirochaetes	203691|Spirochaetes	F	Phospholipid-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
CMS1_k127_3482653_8	1122929.KB908228_gene3958	2.807e-154	509.0	COG0737@1|root,COG0737@2|Bacteria,1MZYF@1224|Proteobacteria,2TUKP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
CMS1_k127_3565983_2	158189.SpiBuddy_2634	2.158e-59	214.0	COG2972@1|root,COG2972@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
CMS1_k127_3565983_0	158189.SpiBuddy_2637	1.2e-131	432.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027,ko:K10192	ko02010,map02010	M00202,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.11	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_3565983_1	1122917.KB899664_gene3008	1.045e-70	245.0	COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,4HB63@91061|Bacilli,26S91@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	ko:K10193	ko02010,map02010	M00202	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.11	-	-	BPD_transp_1
CMS1_k127_3580092_3	158190.SpiGrapes_0315	7.239e-155	492.0	COG1640@1|root,COG1640@2|Bacteria,2J5U4@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
CMS1_k127_3580092_5	158190.SpiGrapes_0314	8.626e-115	372.0	COG0563@1|root,COG0563@2|Bacteria,2J6MV@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
CMS1_k127_3580092_0	158190.SpiGrapes_0313	4.781e-247	767.0	COG1653@1|root,COG1653@2|Bacteria,2J59Z@203691|Spirochaetes	203691|Spirochaetes	G	solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_3580092_2	158190.SpiGrapes_0312	9.344e-173	546.0	COG1175@1|root,COG1175@2|Bacteria,2J70M@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_3580092_4	158190.SpiGrapes_0311	1.582e-144	462.0	COG0395@1|root,COG0395@2|Bacteria,2J6YS@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter (Permease)	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_3580092_1	158190.SpiGrapes_0310	4.187e-213	668.0	COG0035@1|root,COG0035@2|Bacteria,2J5NG@203691|Spirochaetes	203691|Spirochaetes	F	uracil phosphoribosyltransferase	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
CMS1_k127_3580092_7	158190.SpiGrapes_0309	1.726e-54	199.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
CMS1_k127_3580092_6	158190.SpiGrapes_0308	9.89e-87	288.0	COG2059@1|root,COG2059@2|Bacteria,2J859@203691|Spirochaetes	203691|Spirochaetes	P	Chromate	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
CMS1_k127_3580363_0	158190.SpiGrapes_0488	0.0	1434.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
CMS1_k127_3580363_1	158190.SpiGrapes_0489	2.034e-232	725.0	COG0617@1|root,COG1078@1|root,COG0617@2|Bacteria,COG1078@2|Bacteria,2J5ZC@203691|Spirochaetes	203691|Spirochaetes	H	PolyA polymerase	papS	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
CMS1_k127_3580363_3	1307761.L21SP2_1753	2.153e-77	266.0	COG0571@1|root,COG0571@2|Bacteria,2J6UI@203691|Spirochaetes	203691|Spirochaetes	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
CMS1_k127_3580363_6	158190.SpiGrapes_0491	1.338e-37	142.0	COG0236@1|root,COG0236@2|Bacteria,2J8CN@203691|Spirochaetes	203691|Spirochaetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS1_k127_3580363_7	158190.SpiGrapes_0492	6.937e-32	124.0	COG0333@1|root,COG0333@2|Bacteria,2J8XR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
CMS1_k127_3580363_2	158190.SpiGrapes_0493	3.514e-94	310.0	COG0669@1|root,COG0669@2|Bacteria,2J7VS@203691|Spirochaetes	203691|Spirochaetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS1_k127_3580363_4	158190.SpiGrapes_0494	1.599e-76	260.0	2EFYN@1|root,339QT@2|Bacteria,2J98F@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3580363_5	158190.SpiGrapes_0495	4.459e-65	223.0	COG0335@1|root,COG0335@2|Bacteria,2J825@203691|Spirochaetes	203691|Spirochaetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
CMS1_k127_3580363_8	760011.Spico_0513	1.871e-19	89.0	COG0336@1|root,COG0336@2|Bacteria,2J5KR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CMS1_k127_3581235_8	158189.SpiBuddy_2517	1.43e-102	336.0	COG0747@1|root,COG0747@2|Bacteria,2J86R@203691|Spirochaetes	203691|Spirochaetes	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS1_k127_3581235_3	158189.SpiBuddy_2516	1.117e-167	530.0	COG0601@1|root,COG0601@2|Bacteria,2J9KQ@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_3581235_6	158189.SpiBuddy_2515	5.19e-141	451.0	COG1173@1|root,COG1173@2|Bacteria,2J7TS@203691|Spirochaetes	203691|Spirochaetes	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS1_k127_3581235_7	1480694.DC28_07390	4.48e-131	427.0	COG0444@1|root,COG0444@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_3581235_4	158189.SpiBuddy_2513	8.358e-155	495.0	COG4608@1|root,COG4608@2|Bacteria,2J5YH@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_3581235_11	158189.SpiBuddy_2512	6.599e-82	284.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	ycjG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	iEC042_1314.EC042_1441,iECUMN_1333.ECUMN_1620	MR_MLE_C,MR_MLE_N
CMS1_k127_3581235_12	158189.SpiBuddy_2511	8.811e-29	122.0	COG0454@1|root,COG0456@2|Bacteria,2JB1N@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_3581235_9	158189.SpiBuddy_2510	6.715e-99	334.0	COG1680@1|root,COG1680@2|Bacteria,2J5Y0@203691|Spirochaetes	203691|Spirochaetes	V	beta-lactamase	bla	-	3.4.16.4	ko:K21469	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,DUF1343
CMS1_k127_3581235_1	158190.SpiGrapes_2750	8.964e-248	768.0	COG5026@1|root,COG5026@2|Bacteria,2J6A7@203691|Spirochaetes	203691|Spirochaetes	G	hexokinase	-	-	2.7.1.1	ko:K00844	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04910,ko04930,ko04973,ko05230,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200,map04066,map04910,map04930,map04973,map05230	M00001,M00549	R00299,R00760,R00867,R01326,R01600,R01786,R01961,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	Hexokinase_1,Hexokinase_2
CMS1_k127_3581235_0	158190.SpiGrapes_2748	1.074e-280	866.0	COG2925@1|root,COG2925@2|Bacteria,2J9WH@203691|Spirochaetes	203691|Spirochaetes	L	Exonuclease C-terminal	-	-	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
CMS1_k127_3581235_2	158190.SpiGrapes_2746	1.367e-230	717.0	COG0156@1|root,COG0156@2|Bacteria,2J615@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_3581235_5	158190.SpiGrapes_2745	1.688e-144	458.0	COG0451@1|root,COG0451@2|Bacteria,2J62J@203691|Spirochaetes	203691|Spirochaetes	M	NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS1_k127_359086_0	158190.SpiGrapes_1867	5.475e-147	469.0	COG0598@1|root,COG0598@2|Bacteria,2J6SS@203691|Spirochaetes	203691|Spirochaetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS1_k127_359086_3	1408823.AXUS01000014_gene1340	4.547e-38	156.0	COG0454@1|root,COG0456@2|Bacteria,1TS4G@1239|Firmicutes,25DBT@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS1_k127_359086_1	158190.SpiGrapes_1869	6.601e-147	475.0	COG0454@1|root,COG0456@2|Bacteria,2JAQV@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_359086_2	158190.SpiGrapes_1870	1.638e-51	184.0	COG1253@1|root,COG1253@2|Bacteria,2J7S9@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1253 Hemolysins and related protein containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS1_k127_3600894_6	158190.SpiGrapes_3002	5.288e-86	292.0	COG0793@1|root,COG0793@2|Bacteria,2JB6W@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3600894_1	158190.SpiGrapes_3003	2.39e-289	891.0	COG0008@1|root,COG0008@2|Bacteria,2J5M7@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
CMS1_k127_3600894_0	158190.SpiGrapes_3004	3.952e-298	914.0	COG0423@1|root,COG0423@2|Bacteria,2J57N@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
CMS1_k127_3600894_2	158190.SpiGrapes_3005	1.996e-248	769.0	COG0162@1|root,COG0162@2|Bacteria,2J5ZS@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
CMS1_k127_3600894_3	158190.SpiGrapes_3006	4.732e-173	546.0	COG0715@1|root,COG0715@2|Bacteria,2J793@203691|Spirochaetes	203691|Spirochaetes	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
CMS1_k127_3600894_5	158190.SpiGrapes_3007	1.962e-125	406.0	COG0600@1|root,COG0600@2|Bacteria,2J8C5@203691|Spirochaetes	203691|Spirochaetes	P	ABC-type nitrate sulfonate bicarbonate transport system	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran,BPD_transp_1
CMS1_k127_3600894_8	643648.Slip_1020	4.668e-47	178.0	COG1116@1|root,COG1116@2|Bacteria,1V7QX@1239|Firmicutes,24H9Z@186801|Clostridia	186801|Clostridia	P	Abc transporter	-	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
CMS1_k127_3600894_7	158190.SpiGrapes_3009	7.31e-70	239.0	COG2033@1|root,COG2033@2|Bacteria,2J8F0@203691|Spirochaetes	203691|Spirochaetes	C	Desulfoferrodoxin ferrous iron-binding domain	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
CMS1_k127_3600894_4	33035.JPJF01000009_gene1554	3.557e-134	434.0	COG0371@1|root,COG0371@2|Bacteria,1TQFU@1239|Firmicutes,248KH@186801|Clostridia,3XZGH@572511|Blautia	186801|Clostridia	C	COG COG0371 Glycerol dehydrogenase and related enzymes	dhaD	-	1.1.1.6	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	-	R01034,R10715,R10717	RC00029,RC00117,RC00670	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS1_k127_3602776_10	573413.Spirs_2213	9.171e-21	97.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_3602776_0	573413.Spirs_2214	7.289e-254	796.0	COG2936@1|root,COG2936@2|Bacteria	2|Bacteria	V	dipeptidyl-peptidase activity	cocE	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
CMS1_k127_3602776_5	573413.Spirs_2215	2.334e-129	421.0	COG4608@1|root,COG4608@2|Bacteria,2J5YH@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_3602776_3	573413.Spirs_2216	4.436e-138	445.0	COG0444@1|root,COG0444@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS1_k127_3602776_7	573413.Spirs_2217	1.079e-105	350.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
CMS1_k127_3602776_4	573413.Spirs_2218	9.481e-134	433.0	COG0601@1|root,COG0601@2|Bacteria,2J9TU@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_3602776_2	1123274.KB899422_gene25	3.869e-186	595.0	COG0747@1|root,COG0747@2|Bacteria,2JADZ@203691|Spirochaetes	203691|Spirochaetes	E	ABC transporter	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS1_k127_3602776_11	573413.Spirs_2211	3.794e-20	93.0	COG3052@1|root,COG3052@2|Bacteria,2J90H@203691|Spirochaetes	203691|Spirochaetes	C	Covalent carrier of the coenzyme of citrate lyase	citD	-	-	ko:K01646	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001	-	-	-	ACP
CMS1_k127_3602776_6	1123274.KB899422_gene20	2.006e-119	390.0	COG2301@1|root,COG2301@2|Bacteria,2J7CN@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS1_k127_3602776_1	1123274.KB899422_gene19	4.99e-234	733.0	COG3051@1|root,COG3051@2|Bacteria,2J5CP@203691|Spirochaetes	203691|Spirochaetes	H	Citrate (pro-3S)-lyase alpha chain	citF	-	2.8.3.10	ko:K01643	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	CitF
CMS1_k127_3602776_9	1123274.KB899422_gene18	1.586e-34	139.0	COG3697@1|root,COG3697@2|Bacteria,2J8UT@203691|Spirochaetes	203691|Spirochaetes	HI	synthase CitX	citX	-	2.7.7.61	ko:K05964	ko02020,map02020	-	R10706	-	ko00000,ko00001,ko01000	-	-	-	CitX
CMS1_k127_3602776_8	1209989.TepiRe1_2433	4.714e-62	225.0	COG1767@1|root,COG1767@2|Bacteria,1TQGQ@1239|Firmicutes,24BQH@186801|Clostridia	186801|Clostridia	H	synthase	citG	-	2.4.2.52,2.7.7.61	ko:K05966,ko:K13927	ko02020,map02020	-	R09675,R10706	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG,CitX
CMS1_k127_3637600_11	1123257.AUFV01000010_gene3349	1.497e-85	313.0	COG3292@1|root,COG3386@1|root,COG3292@2|Bacteria,COG3386@2|Bacteria,1N3BV@1224|Proteobacteria	1224|Proteobacteria	G	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
CMS1_k127_3637600_1	693746.OBV_36440	1.798e-308	968.0	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,25B73@186801|Clostridia	186801|Clostridia	K	ATP-dependent transcriptional regulator	malT	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_22,GerE
CMS1_k127_3637600_10	693746.OBV_36430	5.554e-119	392.0	COG0842@1|root,COG0842@2|Bacteria,1V4EQ@1239|Firmicutes,24CCM@186801|Clostridia	186801|Clostridia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
CMS1_k127_3637600_9	693746.OBV_36420	1.085e-119	388.0	COG0842@1|root,COG0842@2|Bacteria,1V4X9@1239|Firmicutes,24IW7@186801|Clostridia	186801|Clostridia	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS1_k127_3637600_5	693746.OBV_36410	4.754e-151	482.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia	186801|Clostridia	V	Abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS1_k127_3637600_12	158190.SpiGrapes_2291	1.266e-56	201.0	COG0454@1|root,COG0456@2|Bacteria,2J96Z@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_3637600_4	158190.SpiGrapes_2292	6.482e-188	594.0	COG0477@1|root,COG2814@2|Bacteria,2J8KZ@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_3637600_0	158190.SpiGrapes_1710	0.0	1076.0	COG0028@1|root,COG0028@2|Bacteria,2J5EZ@203691|Spirochaetes	2|Bacteria	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS1_k127_3637600_8	158190.SpiGrapes_2305	5.088e-121	392.0	COG0588@1|root,COG0588@2|Bacteria,2J5CD@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
CMS1_k127_3637600_2	158190.SpiGrapes_1709	5.683e-269	835.0	COG1288@1|root,COG1288@2|Bacteria,2J88I@203691|Spirochaetes	203691|Spirochaetes	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
CMS1_k127_3637600_3	158190.SpiGrapes_1708	2.234e-228	712.0	COG1473@1|root,COG1473@2|Bacteria,2J7EK@203691|Spirochaetes	203691|Spirochaetes	S	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS1_k127_3637600_6	158190.SpiGrapes_1707	4.402e-139	443.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	crp2	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_3637600_7	158190.SpiGrapes_1706	5.661e-134	432.0	COG3681@1|root,COG3681@2|Bacteria,2J6AS@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0597 family	-	-	-	-	-	-	-	-	-	-	-	-	SDH_alpha
CMS1_k127_366713_4	158190.SpiGrapes_1083	4.276e-235	739.0	2F1XI@1|root,33UX3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_366713_5	158190.SpiGrapes_1080	8.224e-225	700.0	COG0707@1|root,COG0707@2|Bacteria	2|Bacteria	M	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity	-	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Alg14,Glyco_tran_28_C
CMS1_k127_366713_8	158190.SpiGrapes_1078	9.109e-171	543.0	COG0438@1|root,COG0438@2|Bacteria,2J7E2@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS1_k127_366713_0	158190.SpiGrapes_1077	0.0	1255.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS1_k127_366713_6	158190.SpiGrapes_1075	1.314e-214	676.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
CMS1_k127_366713_1	158190.SpiGrapes_1074	0.0	1114.0	COG0513@1|root,COG0513@2|Bacteria,2J5RN@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
CMS1_k127_366713_7	158190.SpiGrapes_1073	3.146e-193	606.0	COG3250@1|root,COG3250@2|Bacteria,2J6FW@203691|Spirochaetes	203691|Spirochaetes	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
CMS1_k127_366713_2	158190.SpiGrapes_1071	2.179e-264	823.0	COG0760@1|root,COG0760@2|Bacteria,2J720@203691|Spirochaetes	203691|Spirochaetes	O	PFAM PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,SurA_N_2,SurA_N_3
CMS1_k127_366713_9	1123274.KB899407_gene296	1.158e-82	283.0	COG0451@1|root,COG0451@2|Bacteria,2J9V5@203691|Spirochaetes	203691|Spirochaetes	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
CMS1_k127_3670398_0	158190.SpiGrapes_0074	5.862e-211	662.0	COG0105@1|root,COG0105@2|Bacteria,2J5M6@203691|Spirochaetes	203691|Spirochaetes	F	Nucleoside diphosphate kinase	-	-	-	-	-	-	-	-	-	-	-	-	NDK
CMS1_k127_3670398_1	158189.SpiBuddy_1546	6.407e-10	67.0	COG1409@1|root,COG1409@2|Bacteria,2J6AX@203691|Spirochaetes	203691|Spirochaetes	S	SPTR Serine threonine protein phosphatase family protein	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
CMS1_k127_3675236_5	158190.SpiGrapes_0553	3.795e-47	171.0	COG0234@1|root,COG0234@2|Bacteria,2J8BR@203691|Spirochaetes	203691|Spirochaetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
CMS1_k127_3675236_3	158190.SpiGrapes_0554	2.195e-106	347.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS1_k127_3675236_0	158190.SpiGrapes_0555	0.0	1305.0	COG1199@1|root,COG1199@2|Bacteria,2J626@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,RadC,ResIII
CMS1_k127_3675236_2	237368.SCABRO_03252	6.378e-111	373.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02584,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	FHA,GAF,GAF_2,HTH_8,Sigma54_activat
CMS1_k127_3675236_1	158190.SpiGrapes_0557	1.729e-222	692.0	COG4191@1|root,COG4191@2|Bacteria,2JBGF@203691|Spirochaetes	203691|Spirochaetes	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS1_k127_3678522_1	158189.SpiBuddy_0991	1.166e-68	237.0	COG1020@1|root,COG1020@2|Bacteria,2JBAT@203691|Spirochaetes	203691|Spirochaetes	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
CMS1_k127_3678522_0	158190.SpiGrapes_0508	1.511e-146	465.0	2EH6S@1|root,33AYK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3681644_3	158190.SpiGrapes_0307	8.079e-63	216.0	COG2059@1|root,COG2059@2|Bacteria,2J7W5@203691|Spirochaetes	203691|Spirochaetes	P	Chromate transport protein	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
CMS1_k127_3681644_2	158190.SpiGrapes_0306	5.116e-85	282.0	COG0328@1|root,COG0328@2|Bacteria,2J7Y2@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
CMS1_k127_3681644_1	158190.SpiGrapes_0305	1.277e-127	415.0	COG0614@1|root,COG0614@2|Bacteria,2J7EM@203691|Spirochaetes	203691|Spirochaetes	P	periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS1_k127_3681644_0	158190.SpiGrapes_0304	5.515e-158	503.0	COG0609@1|root,COG0609@2|Bacteria,2J6D8@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
CMS1_k127_3681644_4	698964.CDPW8_0583	1.602e-24	108.0	COG1120@1|root,COG1120@2|Bacteria,2GJ49@201174|Actinobacteria,22JP3@1653|Corynebacteriaceae	201174|Actinobacteria	HP	transport systems ATPase components	ciuD	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS1_k127_374166_0	158190.SpiGrapes_0713	8.888e-307	944.0	COG0488@1|root,COG0488@2|Bacteria,2J6I5@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS1_k127_374166_2	97138.C820_00100	1.488e-34	134.0	COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,24QZK@186801|Clostridia,36JJV@31979|Clostridiaceae	186801|Clostridia	K	regulatory protein, arsR	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
CMS1_k127_374166_1	158190.SpiGrapes_0711	8.489e-81	271.0	COG0701@1|root,COG0701@2|Bacteria,2J7AV@203691|Spirochaetes	203691|Spirochaetes	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
CMS1_k127_3758153_0	158190.SpiGrapes_3013	2.972e-286	884.0	COG1022@1|root,COG1022@2|Bacteria,2J9W8@203691|Spirochaetes	203691|Spirochaetes	I	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
CMS1_k127_3758153_2	158190.SpiGrapes_3012	9.687e-209	657.0	COG0402@1|root,COG0402@2|Bacteria,2J9KY@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS1_k127_3758153_3	158190.SpiGrapes_3011	1.054e-204	639.0	COG0182@1|root,COG0182@2|Bacteria,2J7HQ@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
CMS1_k127_3758153_1	158190.SpiGrapes_3010	1.428e-273	844.0	COG0334@1|root,COG0334@2|Bacteria,2J5DD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdh	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS1_k127_3762550_1	158189.SpiBuddy_0761	5.716e-169	534.0	COG1175@1|root,COG1175@2|Bacteria,2JAFT@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_3762550_2	158189.SpiBuddy_0760	2.883e-145	466.0	COG0395@1|root,COG0395@2|Bacteria,2J7M9@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter (Permease)	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_3762550_0	158189.SpiBuddy_0759	0.0	1042.0	COG3533@1|root,COG3533@2|Bacteria,2J76E@203691|Spirochaetes	203691|Spirochaetes	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
CMS1_k127_3762550_3	416591.Tlet_1099	1.552e-75	277.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
CMS1_k127_3762550_4	1203606.HMPREF1526_01704	1.338e-47	175.0	COG0454@1|root,COG0456@2|Bacteria,1V3IC@1239|Firmicutes,24HK5@186801|Clostridia,36JMS@31979|Clostridiaceae	186801|Clostridia	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
CMS1_k127_3762550_5	349521.HCH_00926	7.38e-43	160.0	COG3631@1|root,COG3631@2|Bacteria,1N05P@1224|Proteobacteria,1SBGY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
CMS1_k127_3762550_6	1408324.JNJK01000013_gene73	2.105e-14	75.0	COG3064@1|root,COG3064@2|Bacteria,1V588@1239|Firmicutes,25G3U@186801|Clostridia,27RWG@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Host cell surface-exposed lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_Ltp
CMS1_k127_3772237_0	158190.SpiGrapes_1515	2.059e-237	736.0	COG2942@1|root,COG2942@2|Bacteria,2J5MD@203691|Spirochaetes	203691|Spirochaetes	G	PFAM N-acylglucosamine 2-epimerase	-	-	5.1.3.8	ko:K01787	ko00520,map00520	-	R01207	RC00290	ko00000,ko00001,ko01000	-	-	-	GlcNAc_2-epim
CMS1_k127_3772237_1	158190.SpiGrapes_1516	1.077e-132	425.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	MA20_15070	-	-	ko:K22293	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_3779933_0	33035.JPJF01000040_gene5179	8.702e-246	778.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,24DH1@186801|Clostridia	186801|Clostridia	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
CMS1_k127_3779933_1	33035.JPJF01000040_gene5180	1.34e-73	250.0	COG0395@1|root,COG0395@2|Bacteria,1TRGH@1239|Firmicutes,24C7R@186801|Clostridia	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_3804415_1	158190.SpiGrapes_0397	1.136e-142	456.0	COG0217@1|root,COG0217@2|Bacteria,2J634@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
CMS1_k127_3804415_0	158190.SpiGrapes_0396	9.459e-150	481.0	COG0635@1|root,COG0635@2|Bacteria,2J5R4@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS1_k127_3831381_7	158190.SpiGrapes_0629	1.141e-76	258.0	COG0483@1|root,COG0483@2|Bacteria,2J7MC@203691|Spirochaetes	203691|Spirochaetes	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS1_k127_3831381_3	158190.SpiGrapes_0630	2.73e-130	418.0	COG1738@1|root,COG1738@2|Bacteria,2J7JS@203691|Spirochaetes	203691|Spirochaetes	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
CMS1_k127_3831381_4	158190.SpiGrapes_0632	4.875e-126	405.0	COG0527@1|root,COG0527@2|Bacteria,2JADH@203691|Spirochaetes	203691|Spirochaetes	E	aspartate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3831381_5	158190.SpiGrapes_0633	2.239e-83	279.0	COG1327@1|root,COG1327@2|Bacteria,2J7FW@203691|Spirochaetes	203691|Spirochaetes	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
CMS1_k127_3831381_1	158190.SpiGrapes_0634	3.544e-216	674.0	COG0232@1|root,COG0232@2|Bacteria,2J69E@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Metal-dependent phosphohydrolase, HD	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
CMS1_k127_3831381_6	158190.SpiGrapes_0636	2.038e-82	276.0	COG0703@1|root,COG0703@2|Bacteria,2J7UD@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
CMS1_k127_3831381_2	158190.SpiGrapes_0637	2.015e-187	590.0	COG0082@1|root,COG0082@2|Bacteria,2J5CX@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
CMS1_k127_3831381_0	158190.SpiGrapes_0638	0.0	1037.0	COG1061@1|root,COG1061@2|Bacteria,2J6EB@203691|Spirochaetes	203691|Spirochaetes	L	DNA or RNA helicase of superfamily II	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
CMS1_k127_3834222_1	573413.Spirs_1225	6.077e-36	140.0	COG1917@1|root,COG2169@1|root,COG1917@2|Bacteria,COG2169@2|Bacteria,2J90W@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
CMS1_k127_3834222_0	573413.Spirs_1224	7.977e-252	793.0	COG1472@1|root,COG1472@2|Bacteria,2J60D@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CMS1_k127_3849722_3	158190.SpiGrapes_0163	7.094e-129	417.0	COG0438@1|root,COG0438@2|Bacteria,2J7E2@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS1_k127_3849722_6	446465.Bfae_30090	2.178e-58	211.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4FC4W@85020|Dermabacteraceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	gluA	-	-	ko:K10008	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.9	-	-	ABC_tran
CMS1_k127_3849722_2	158190.SpiGrapes_0160	2.708e-132	426.0	COG0765@1|root,COG0765@2|Bacteria,2J5BG@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
CMS1_k127_3849722_1	158190.SpiGrapes_0159	1.475e-132	430.0	COG0834@1|root,COG0834@2|Bacteria	2|Bacteria	ET	amino acid transport	glnH	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS1_k127_3849722_4	158190.SpiGrapes_0157	2.154e-126	408.0	COG1126@1|root,COG1126@2|Bacteria,2J5V5@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
CMS1_k127_3849722_5	158190.SpiGrapes_0156	4.717e-121	390.0	COG0765@1|root,COG0765@2|Bacteria,2J84E@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
CMS1_k127_3849722_0	158190.SpiGrapes_0155	3.41e-133	428.0	COG0834@1|root,COG0834@2|Bacteria,2JA1B@203691|Spirochaetes	203691|Spirochaetes	ET	PFAM Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS1_k127_3849722_7	158190.SpiGrapes_0154	8.748e-52	189.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS1_k127_3849722_8	158190.SpiGrapes_0154	1.211e-21	96.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS1_k127_3849795_8	158190.SpiGrapes_1167	1.483e-228	709.0	COG3842@1|root,COG3842@2|Bacteria,2J5T3@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
CMS1_k127_3849795_5	158190.SpiGrapes_1169	2.252e-238	743.0	COG0527@1|root,COG0527@2|Bacteria,2J6FK@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
CMS1_k127_3849795_9	158190.SpiGrapes_1170	1.595e-221	694.0	COG0534@1|root,COG0534@2|Bacteria,2J593@203691|Spirochaetes	203691|Spirochaetes	V	efflux protein, MATE family	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_3849795_3	158190.SpiGrapes_1171	3.977e-320	982.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2J5C7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Asn_synthase,GATase,GMP_synt_C,NAD_synthase
CMS1_k127_3849795_18	158190.SpiGrapes_1172	1.167e-88	294.0	COG4720@1|root,COG4720@2|Bacteria	2|Bacteria	P	Psort location CytoplasmicMembrane, score	XK27_01265	-	-	ko:K16923,ko:K16924	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.28,3.A.1.29	-	-	ECF-ribofla_trS
CMS1_k127_3849795_15	158190.SpiGrapes_1173	1.152e-132	427.0	COG0619@1|root,COG0619@2|Bacteria,2J7RZ@203691|Spirochaetes	203691|Spirochaetes	P	cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
CMS1_k127_3849795_4	158190.SpiGrapes_1174	2.728e-244	760.0	COG1122@1|root,COG1122@2|Bacteria,2J5SA@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
CMS1_k127_3849795_17	158190.SpiGrapes_1175	5.394e-110	360.0	COG0204@1|root,COG0204@2|Bacteria,2J7RR@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS1_k127_3849795_2	158190.SpiGrapes_1176	5.34e-322	1001.0	COG1132@1|root,COG1132@2|Bacteria,2J5W8@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS1_k127_3849795_10	760011.Spico_1330	1.13e-200	639.0	COG0513@1|root,COG0513@2|Bacteria,2J5U7@203691|Spirochaetes	203691|Spirochaetes	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
CMS1_k127_3849795_14	158190.SpiGrapes_1178	1.451e-133	429.0	COG0115@1|root,COG0115@2|Bacteria	2|Bacteria	E	branched-chain-amino-acid transaminase activity	ilvE	GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.21,2.6.1.42	ko:K00824,ko:K00826	ko00270,ko00280,ko00290,ko00310,ko00330,ko00360,ko00472,ko00473,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01148,R01214,R01582,R02199,R02459,R02851,R02924,R05053,R10991	RC00006,RC00008,RC00025,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iB21_1397.B21_03597,iECBD_1354.ECBD_4269,iECB_1328.ECB_03648,iECD_1391.ECD_03648,iECO103_1326.ECO103_4394	Aminotran_4
CMS1_k127_3849795_0	158190.SpiGrapes_1179	0.0	1260.0	COG1674@1|root,COG1674@2|Bacteria,2J63D@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
CMS1_k127_3849795_19	760011.Spico_1333	3.592e-63	223.0	COG0357@1|root,COG0357@2|Bacteria,2J72Y@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
CMS1_k127_3849795_1	158190.SpiGrapes_1181	0.0	1112.0	COG0445@1|root,COG0445@2|Bacteria,2J5A1@203691|Spirochaetes	203691|Spirochaetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
CMS1_k127_3849795_6	158190.SpiGrapes_1182	8.506e-236	736.0	COG0486@1|root,COG0486@2|Bacteria,2J5GU@203691|Spirochaetes	203691|Spirochaetes	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
CMS1_k127_3849795_11	158190.SpiGrapes_1183	7.137e-195	610.0	COG2269@1|root,COG2269@2|Bacteria,2J61T@203691|Spirochaetes	203691|Spirochaetes	J	synthetase (class II)	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
CMS1_k127_3849795_16	158190.SpiGrapes_1184	1.735e-114	369.0	COG0231@1|root,COG0231@2|Bacteria,2J69Z@203691|Spirochaetes	203691|Spirochaetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
CMS1_k127_3849795_7	158189.SpiBuddy_0830	5.027e-233	726.0	COG1653@1|root,COG1653@2|Bacteria,2JA1G@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding, family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
CMS1_k127_3849795_12	158189.SpiBuddy_0829	1.21e-167	529.0	COG1175@1|root,COG1175@2|Bacteria,2J7PS@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_3849795_13	158189.SpiBuddy_0828	2.366e-160	509.0	COG0395@1|root,COG0395@2|Bacteria,2J9WE@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_384985_4	158190.SpiGrapes_0543	5.814e-52	184.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J5JP@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS1_k127_384985_1	158190.SpiGrapes_0544	2.046e-156	496.0	COG1028@1|root,COG1028@2|Bacteria,2J6PM@203691|Spirochaetes	203691|Spirochaetes	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
CMS1_k127_384985_0	158190.SpiGrapes_0545	7.162e-166	524.0	COG3717@1|root,COG3717@2|Bacteria,2J59E@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate	kduI	-	5.3.1.17	ko:K01815	ko00040,map00040	-	R04383	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
CMS1_k127_384985_3	158189.SpiBuddy_1287	2.987e-80	274.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	ydfH1	-	-	ko:K22293	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_384985_2	158190.SpiGrapes_0551	3.631e-94	310.0	COG0568@1|root,COG0568@2|Bacteria,2J5M9@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS1_k127_3866419_4	290402.Cbei_1938	5.309e-24	102.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,36GMS@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
CMS1_k127_3866419_2	913865.DOT_3886	1.953e-83	285.0	COG0600@1|root,COG0600@2|Bacteria,1UPIJ@1239|Firmicutes,24B1E@186801|Clostridia,264JY@186807|Peptococcaceae	186801|Clostridia	U	transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
CMS1_k127_3866419_3	545694.TREPR_0428	1.063e-76	268.0	COG0600@1|root,COG0600@2|Bacteria,2JAAY@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
CMS1_k127_3866419_1	545694.TREPR_0427	9.758e-104	348.0	COG0715@1|root,COG0715@2|Bacteria,2JAFQ@203691|Spirochaetes	203691|Spirochaetes	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	HATPase_c,NMT1
CMS1_k127_3866419_0	1449050.JNLE01000003_gene2648	2.443e-215	677.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,36EQM@31979|Clostridiaceae	186801|Clostridia	F	PFAM amidohydrolase	hydA_1	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1,Urease_alpha
CMS1_k127_3873274_40	158190.SpiGrapes_2182	6.383e-25	103.0	COG0151@1|root,COG0151@2|Bacteria,2J9IF@203691|Spirochaetes	203691|Spirochaetes	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	-	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
CMS1_k127_3873274_35	158190.SpiGrapes_2181	1.598e-45	168.0	COG3370@1|root,COG3370@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
CMS1_k127_3873274_21	158190.SpiGrapes_2180	9.94e-103	344.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0017057,GO:0044424,GO:0044444,GO:0044464,GO:0052689	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	iSSON_1240.SSON_0741	Lactonase
CMS1_k127_3873274_5	158190.SpiGrapes_2179	3.71e-281	875.0	2C3NG@1|root,348TB@2|Bacteria,2J5WS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi
CMS1_k127_3873274_4	158190.SpiGrapes_2178	7.233e-295	914.0	28MEQ@1|root,2ZASC@2|Bacteria,2JBF7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3873274_30	158190.SpiGrapes_2177	1.978e-65	227.0	2DQ94@1|root,335DB@2|Bacteria,2J7K8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3873274_10	158190.SpiGrapes_2176	1.593e-213	672.0	COG1172@1|root,COG1172@2|Bacteria,2J5CE@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_3873274_11	158190.SpiGrapes_2175	9.373e-206	642.0	COG1172@1|root,COG1172@2|Bacteria,2J5SV@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_3873274_2	158190.SpiGrapes_2174	1.763e-306	945.0	COG1129@1|root,COG1129@2|Bacteria,2J67Y@203691|Spirochaetes	203691|Spirochaetes	G	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_3873274_7	158190.SpiGrapes_2173	3.697e-250	775.0	COG1609@1|root,COG1609@2|Bacteria,2J5E7@203691|Spirochaetes	203691|Spirochaetes	K	Protein of unknown function (DUF3798)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3798
CMS1_k127_3873274_14	158190.SpiGrapes_2172	2.997e-144	459.0	COG0566@1|root,COG0566@2|Bacteria,2J748@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS1_k127_3873274_8	158190.SpiGrapes_2171	1.737e-230	715.0	COG0484@1|root,COG0484@2|Bacteria,2J614@203691|Spirochaetes	203691|Spirochaetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS1_k127_3873274_0	158190.SpiGrapes_2170	0.0	1164.0	COG0443@1|root,COG0443@2|Bacteria,2J5I0@203691|Spirochaetes	203691|Spirochaetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS1_k127_3873274_24	158190.SpiGrapes_2169	1.091e-87	293.0	COG0576@1|root,COG0576@2|Bacteria,2J7UP@203691|Spirochaetes	203691|Spirochaetes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CMS1_k127_3873274_23	158190.SpiGrapes_2168	9.288e-98	336.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	CP_0646	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	DUF1978,Mob_Pre
CMS1_k127_3873274_19	158190.SpiGrapes_2167	8.737e-109	357.0	COG1011@1|root,COG1011@2|Bacteria,2JBH2@203691|Spirochaetes	203691|Spirochaetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
CMS1_k127_3873274_12	760011.Spico_1684	1.691e-202	642.0	COG1160@1|root,COG1160@2|Bacteria,2J5GG@203691|Spirochaetes	203691|Spirochaetes	I	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
CMS1_k127_3873274_1	158190.SpiGrapes_2165	0.0	1016.0	COG1080@1|root,COG1080@2|Bacteria,2J5FB@203691|Spirochaetes	203691|Spirochaetes	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
CMS1_k127_3873274_37	158189.SpiBuddy_2820	1.786e-35	141.0	COG5401@1|root,COG5401@2|Bacteria	2|Bacteria	T	PFAM Sporulation and spore germination	-	-	3.5.1.28	ko:K01448,ko:K06298	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Germane
CMS1_k127_3873274_15	158190.SpiGrapes_2163	4.579e-138	441.0	COG1189@1|root,COG1189@2|Bacteria,2J8G3@203691|Spirochaetes	203691|Spirochaetes	J	TIGRFAM hemolysin TlyA family protein	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
CMS1_k127_3873274_13	158190.SpiGrapes_2162	2.144e-159	503.0	COG1692@1|root,COG1692@2|Bacteria,2J7C4@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
CMS1_k127_3873274_3	158190.SpiGrapes_2161	4.717e-298	918.0	COG1418@1|root,COG1418@2|Bacteria,2J5IM@203691|Spirochaetes	203691|Spirochaetes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
CMS1_k127_3873274_36	1123274.KB899411_gene3088	6.387e-38	148.0	COG0203@1|root,COG0203@2|Bacteria,2J841@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
CMS1_k127_3873274_9	158190.SpiGrapes_2159	7.495e-220	683.0	COG0202@1|root,COG0202@2|Bacteria,2J58K@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
CMS1_k127_3873274_17	158190.SpiGrapes_2158	1.266e-131	420.0	COG0522@1|root,COG0522@2|Bacteria,2J6UK@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CMS1_k127_3873274_28	158190.SpiGrapes_2157	1.236e-72	245.0	COG0100@1|root,COG0100@2|Bacteria,2J7BP@203691|Spirochaetes	203691|Spirochaetes	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
CMS1_k127_3873274_32	158190.SpiGrapes_2156	9.237e-65	222.0	COG0099@1|root,COG0099@2|Bacteria,2J7QU@203691|Spirochaetes	203691|Spirochaetes	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
CMS1_k127_3873274_42	573413.Spirs_0976	1.572e-16	79.0	COG0257@1|root,COG0257@2|Bacteria,2J989@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
CMS1_k127_3873274_6	158190.SpiGrapes_2154	4.695e-261	807.0	COG0201@1|root,COG0201@2|Bacteria,2J5BH@203691|Spirochaetes	203691|Spirochaetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
CMS1_k127_3873274_26	158190.SpiGrapes_2153	8.944e-81	270.0	COG0200@1|root,COG0200@2|Bacteria,2J7ZW@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
CMS1_k127_3873274_41	158190.SpiGrapes_2152	1.225e-24	104.0	COG1841@1|root,COG1841@2|Bacteria,2J8RV@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
CMS1_k127_3873274_22	158190.SpiGrapes_2151	7.693e-101	329.0	COG0098@1|root,COG0098@2|Bacteria,2J60F@203691|Spirochaetes	203691|Spirochaetes	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
CMS1_k127_3873274_31	158190.SpiGrapes_2150	3.757e-65	223.0	COG0256@1|root,COG0256@2|Bacteria,2J7YP@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
CMS1_k127_3873274_20	158190.SpiGrapes_2149	1.003e-105	344.0	COG0097@1|root,COG0097@2|Bacteria,2J7WB@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
CMS1_k127_3873274_27	158190.SpiGrapes_2148	2.531e-78	262.0	COG0096@1|root,COG0096@2|Bacteria,2J7SM@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
CMS1_k127_3873274_39	158190.SpiGrapes_2147	1.357e-33	130.0	COG0199@1|root,COG0199@2|Bacteria,2J8U1@203691|Spirochaetes	203691|Spirochaetes	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
CMS1_k127_3873274_18	158190.SpiGrapes_2146	1.734e-109	355.0	COG0094@1|root,COG0094@2|Bacteria,2J5DT@203691|Spirochaetes	203691|Spirochaetes	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
CMS1_k127_3873274_33	158190.SpiGrapes_2145	2.796e-55	194.0	COG0198@1|root,COG0198@2|Bacteria,2J94T@203691|Spirochaetes	203691|Spirochaetes	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
CMS1_k127_3873274_29	158190.SpiGrapes_2144	6.293e-72	243.0	COG0093@1|root,COG0093@2|Bacteria,2J7N1@203691|Spirochaetes	203691|Spirochaetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
CMS1_k127_3873274_34	158190.SpiGrapes_2143	8.543e-46	165.0	COG0186@1|root,COG0186@2|Bacteria,2J8JX@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
CMS1_k127_3873274_38	158190.SpiGrapes_2142	1.006e-33	130.0	COG0255@1|root,COG0255@2|Bacteria,2J96Q@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
CMS1_k127_3873274_25	158190.SpiGrapes_2141	3.89e-84	279.0	COG0197@1|root,COG0197@2|Bacteria,2J7H3@203691|Spirochaetes	203691|Spirochaetes	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
CMS1_k127_3873274_16	158190.SpiGrapes_2140	5.491e-135	430.0	COG0092@1|root,COG0092@2|Bacteria,2J5AK@203691|Spirochaetes	203691|Spirochaetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
CMS1_k127_3876503_2	573413.Spirs_2746	5.184e-82	288.0	COG2207@1|root,COG4936@1|root,COG2207@2|Bacteria,COG4936@2|Bacteria,2J7GZ@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PocR
CMS1_k127_3876503_1	632518.Calow_0262	5.054e-110	379.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
CMS1_k127_3876503_0	180332.JTGN01000010_gene4552	1.608e-198	633.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia	186801|Clostridia	G	Alpha-L-rhamnosidase N-terminal domain protein	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
CMS1_k127_3887513_0	158190.SpiGrapes_2914	0.0	1002.0	COG1283@1|root,COG1283@2|Bacteria,2J64N@203691|Spirochaetes	203691|Spirochaetes	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
CMS1_k127_3891017_1	742735.HMPREF9467_02673	1.104e-20	99.0	COG1653@1|root,COG1653@2|Bacteria,1UYEX@1239|Firmicutes,24FEV@186801|Clostridia,21YZJ@1506553|Lachnoclostridium	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
CMS1_k127_3891017_0	1226325.HMPREF1548_02654	1.124e-74	261.0	COG1175@1|root,COG1175@2|Bacteria,1TRC0@1239|Firmicutes,25C59@186801|Clostridia,36WPU@31979|Clostridiaceae	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_3891017_2	1231336.L248_1609	6.606e-11	64.0	COG0395@1|root,COG0395@2|Bacteria,1UCH2@1239|Firmicutes,4HECV@91061|Bacilli,3F3N5@33958|Lactobacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	msmG	-	-	ko:K02026,ko:K10122	-	M00197,M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1,3.A.1.1.20	-	-	BPD_transp_1
CMS1_k127_3891521_7	158190.SpiGrapes_0665	3.656e-14	73.0	COG0137@1|root,COG0137@2|Bacteria,2J5QQ@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
CMS1_k127_3891521_5	158190.SpiGrapes_0664	4.89e-110	361.0	COG1131@1|root,COG1131@2|Bacteria,2J5JM@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_3891521_8	62977.ACIAD3567	1.922e-05	55.0	COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,1RNJE@1236|Gammaproteobacteria,3NJTN@468|Moraxellaceae	1236|Gammaproteobacteria	E	phosphoserine phosphatase	serB	GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004647,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006563,GO:0006564,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019752,GO:0042133,GO:0042136,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046872,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	iE2348C_1286.E2348C_4686,iEC042_1314.EC042_4885,iECO26_1355.ECO26_5594,iECSF_1327.ECSF_4321,iECUMN_1333.ECUMN_5012,iETEC_1333.ETEC_4743,iPC815.YPO0442,iUMNK88_1353.UMNK88_5307	ACT_6,HAD,Hydrolase
CMS1_k127_3891521_2	158190.SpiGrapes_0661	1.719e-193	606.0	COG0330@1|root,COG0330@2|Bacteria,2J5TU@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CMS1_k127_3891521_3	158190.SpiGrapes_0660	3.432e-190	596.0	COG0330@1|root,COG0330@2|Bacteria,2J5A8@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
CMS1_k127_3891521_0	158190.SpiGrapes_0659	0.0	1410.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2J699@203691|Spirochaetes	203691|Spirochaetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
CMS1_k127_3891521_6	760011.Spico_0704	1.833e-54	205.0	COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes	203691|Spirochaetes	V	Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
CMS1_k127_3891521_1	158190.SpiGrapes_0657	7.566e-253	784.0	COG0771@1|root,COG0771@2|Bacteria,2J5IW@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS1_k127_3897502_6	158190.SpiGrapes_0731	8.197e-76	256.0	COG1139@1|root,COG1139@2|Bacteria,2J8P7@203691|Spirochaetes	203691|Spirochaetes	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
CMS1_k127_3897502_2	158190.SpiGrapes_0732	3.997e-198	623.0	COG1979@1|root,COG1979@2|Bacteria,2J57G@203691|Spirochaetes	203691|Spirochaetes	C	Dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
CMS1_k127_3897502_5	158190.SpiGrapes_0734	8.839e-77	260.0	COG1762@1|root,COG1762@2|Bacteria,2J7SC@203691|Spirochaetes	203691|Spirochaetes	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
CMS1_k127_3897502_10	304371.MCP_2012	6.083e-08	61.0	COG0589@1|root,arCOG02053@2157|Archaea,2XYAN@28890|Euryarchaeota	28890|Euryarchaeota	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS1_k127_3897502_3	158190.SpiGrapes_0736	3.398e-123	397.0	COG1394@1|root,COG1394@2|Bacteria,2J5V1@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
CMS1_k127_3897502_1	760011.Spico_0756	2.709e-248	772.0	COG1156@1|root,COG1156@2|Bacteria,2J5SP@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS1_k127_3897502_0	158190.SpiGrapes_0738	0.0	1116.0	COG1155@1|root,COG1155@2|Bacteria,2J5EF@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
CMS1_k127_3897502_8	158189.SpiBuddy_1147	1.242e-54	199.0	COG1390@1|root,COG1390@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
CMS1_k127_3897502_7	158190.SpiGrapes_0740	1.132e-56	198.0	COG1436@1|root,COG1436@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
CMS1_k127_3897502_9	158190.SpiGrapes_0741	1.574e-42	158.0	COG0636@1|root,COG0636@2|Bacteria,2J8ME@203691|Spirochaetes	203691|Spirochaetes	P	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
CMS1_k127_3897502_4	158190.SpiGrapes_0742	3.993e-121	391.0	COG1269@1|root,COG1269@2|Bacteria,2J6DX@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
CMS1_k127_3899267_0	158190.SpiGrapes_1260	1.631e-261	811.0	COG0786@1|root,COG0786@2|Bacteria,2J7YK@203691|Spirochaetes	203691|Spirochaetes	E	glutamate symporter	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
CMS1_k127_3899267_1	158190.SpiGrapes_1259	9.45e-189	596.0	COG0204@1|root,COG1403@1|root,COG0204@2|Bacteria,COG1403@2|Bacteria,2JAJG@203691|Spirochaetes	203691|Spirochaetes	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS1_k127_3899267_7	693746.OBV_08850	1.279e-60	214.0	COG1418@1|root,COG1418@2|Bacteria,1V70P@1239|Firmicutes,24JTJ@186801|Clostridia,2N7Z0@216572|Oscillospiraceae	186801|Clostridia	S	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS1_k127_3899267_5	478749.BRYFOR_06064	1.192e-103	344.0	COG4667@1|root,COG4667@2|Bacteria,1TQ9W@1239|Firmicutes,2485C@186801|Clostridia	186801|Clostridia	S	Phospholipase, patatin family	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
CMS1_k127_3899267_2	158190.SpiGrapes_1257	2.774e-178	562.0	COG1893@1|root,COG1893@2|Bacteria,2J93U@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
CMS1_k127_3899267_4	158190.SpiGrapes_1256	8.278e-125	404.0	2BYH0@1|root,2ZDJM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3899267_10	1298920.KI911353_gene4724	5.444e-14	78.0	COG0624@1|root,COG0624@2|Bacteria,1TYR6@1239|Firmicutes,249CA@186801|Clostridia,21ZDX@1506553|Lachnoclostridium	186801|Clostridia	E	peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_3899267_8	1304866.K413DRAFT_0687	2.138e-28	120.0	COG0624@1|root,COG0624@2|Bacteria,1TYR6@1239|Firmicutes,249CA@186801|Clostridia,36EZ9@31979|Clostridiaceae	186801|Clostridia	E	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_3899267_3	158190.SpiGrapes_2385	5.039e-143	457.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS1_k127_3899267_6	1140002.I570_02497	2.223e-63	220.0	COG3631@1|root,COG3631@2|Bacteria,1V5TX@1239|Firmicutes,4I78K@91061|Bacilli,4B2M1@81852|Enterococcaceae	91061|Bacilli	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS1_k127_3899267_9	500633.CLOHIR_00519	9.563e-24	104.0	COG1106@1|root,COG1106@2|Bacteria,1UDAD@1239|Firmicutes,24B5G@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
CMS1_k127_3899267_11	158189.SpiBuddy_2137	0.0004362	43.0	COG1106@1|root,COG1106@2|Bacteria	2|Bacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K06926	-	-	-	-	ko00000	-	-	-	AAA_15,AAA_21
CMS1_k127_3917615_0	158190.SpiGrapes_0103	6.177e-129	415.0	COG5002@1|root,COG5002@2|Bacteria,2J6AJ@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,sCache_like
CMS1_k127_3917615_1	158190.SpiGrapes_0101	2.639e-92	308.0	COG1192@1|root,COG1192@2|Bacteria,2JBGG@203691|Spirochaetes	203691|Spirochaetes	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3920523_0	158190.SpiGrapes_3238	9.509e-245	765.0	COG0285@1|root,COG0285@2|Bacteria,2J5CZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM folylpolyglutamate synthase dihydrofolate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS1_k127_3920523_3	767029.HMPREF9154_2138	1.609e-52	196.0	COG1120@1|root,COG1120@2|Bacteria,2GJ49@201174|Actinobacteria,4DQ2B@85009|Propionibacteriales	201174|Actinobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS1_k127_3920523_1	158190.SpiGrapes_3240	7.118e-121	397.0	COG0609@1|root,COG0609@2|Bacteria,2J7S0@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
CMS1_k127_3920523_2	158190.SpiGrapes_3241	2.874e-99	329.0	COG0614@1|root,COG0614@2|Bacteria,2J94K@203691|Spirochaetes	203691|Spirochaetes	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS1_k127_3960929_2	158190.SpiGrapes_0051	2.42e-151	483.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	draG	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH,Inositol_P
CMS1_k127_3960929_1	158190.SpiGrapes_0052	5.179e-184	583.0	COG1453@1|root,COG1453@2|Bacteria,2J73V@203691|Spirochaetes	203691|Spirochaetes	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
CMS1_k127_3960929_3	158190.SpiGrapes_0060	2.308e-106	352.0	COG0204@1|root,COG0204@2|Bacteria,2JAHQ@203691|Spirochaetes	203691|Spirochaetes	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS1_k127_3960929_0	158190.SpiGrapes_0065	4.105e-259	806.0	COG0348@1|root,COG0348@2|Bacteria,2J5CW@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_5
CMS1_k127_3960929_5	158190.SpiGrapes_0066	1.436e-38	147.0	2EG8Z@1|root,32UBD@2|Bacteria,2JAYE@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3960929_4	926561.KB900618_gene437	1.548e-65	233.0	COG0716@1|root,COG1145@1|root,COG0716@2|Bacteria,COG1145@2|Bacteria,1TRYM@1239|Firmicutes,247NM@186801|Clostridia	186801|Clostridia	C	4Fe-4S binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Flavodoxin_3,Flavodoxin_5
CMS1_k127_3960929_6	158190.SpiGrapes_0068	8.03e-07	51.0	COG4129@1|root,COG4129@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FUSC_2
CMS1_k127_3969029_11	861452.HMPREF9093_00207	2.123e-18	91.0	COG1131@1|root,COG1131@2|Bacteria,37CUH@32066|Fusobacteria	32066|Fusobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS1_k127_3969029_5	1536774.H70357_24220	1.392e-122	396.0	COG0745@1|root,COG0745@2|Bacteria,1TT12@1239|Firmicutes,4HDD2@91061|Bacilli,26TGC@186822|Paenibacillaceae	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_3969029_1	1536774.H70357_24215	2.909e-203	639.0	COG0642@1|root,COG2205@2|Bacteria,1TT7F@1239|Firmicutes,4HAPG@91061|Bacilli,26VWM@186822|Paenibacillaceae	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS1_k127_3969029_6	1195236.CTER_4928	9.326e-111	362.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3WH0X@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_3969029_0	1536774.H70357_24205	0.0	1208.0	COG0577@1|root,COG0577@2|Bacteria,1TRAS@1239|Firmicutes,4HC7R@91061|Bacilli,26S5Z@186822|Paenibacillaceae	91061|Bacilli	V	Cell division protein FtsX	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS1_k127_3969029_8	1123274.KB899410_gene3420	3.036e-56	204.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	glpQ2	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS1_k127_3969029_4	573413.Spirs_3873	7.758e-123	399.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026,ko:K17313	ko02010,map02010	M00207,M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.15	-	-	BPD_transp_1
CMS1_k127_3969029_3	1123274.KB899410_gene3418	6.39e-125	407.0	COG1175@1|root,COG1175@2|Bacteria,2JAH8@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_3969029_2	1123274.KB899410_gene3417	8.208e-199	627.0	COG1653@1|root,COG1653@2|Bacteria,2J6UA@203691|Spirochaetes	203691|Spirochaetes	G	COGs COG1653 ABC-type sugar transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_3969029_9	1123274.KB899410_gene3416	5.391e-54	203.0	COG1349@1|root,COG1349@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_11,HTH_24,HTH_DeoR,TrmB
CMS1_k127_3969029_7	906968.Trebr_0149	1.758e-68	240.0	COG0551@1|root,COG0551@2|Bacteria,2J8GZ@203691|Spirochaetes	203691|Spirochaetes	L	Topoisomerase DNA binding C4 zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	NERD,zf-C4_Topoisom
CMS1_k127_3969029_10	573413.Spirs_2213	5.701e-36	143.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_4002150_0	158190.SpiGrapes_1088	9.973e-142	460.0	COG1442@1|root,COG1442@2|Bacteria,2J6QB@203691|Spirochaetes	203691|Spirochaetes	M	PFAM glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
CMS1_k127_4002150_1	158190.SpiGrapes_1087	7.413e-68	234.0	COG2148@1|root,COG2148@2|Bacteria,2J8KM@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS1_k127_403803_1	879212.DespoDRAFT_01118	3.674e-32	136.0	COG5340@1|root,COG5340@2|Bacteria,1MY3Y@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator, AbiEi antitoxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_3,AbiEi_3_N
CMS1_k127_403803_0	1391647.AVSV01000022_gene2354	4.192e-69	243.0	COG0725@1|root,COG0725@2|Bacteria,1UJ71@1239|Firmicutes,25D58@186801|Clostridia	186801|Clostridia	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
CMS1_k127_4056894_7	158190.SpiGrapes_2489	2.728e-138	451.0	COG2195@1|root,COG2195@2|Bacteria,2J59I@203691|Spirochaetes	203691|Spirochaetes	E	Cleaves the N-terminal amino acid of tripeptides	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
CMS1_k127_4056894_4	180332.JTGN01000001_gene4780	5.401e-176	560.0	COG3669@1|root,COG3669@2|Bacteria,1TQH2@1239|Firmicutes,24B8Y@186801|Clostridia	186801|Clostridia	G	Psort location Cytoplasmic, score	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,CBM_6,F5_F8_type_C
CMS1_k127_4056894_16	180332.JTGN01000001_gene4783	1.155e-67	240.0	COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia	186801|Clostridia	P	ABC-type sugar transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_4056894_14	658655.HMPREF0988_01101	3.946e-89	303.0	COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,27IXK@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_4056894_13	658655.HMPREF0988_01103	1.429e-95	328.0	COG1653@1|root,COG1653@2|Bacteria,1TSDX@1239|Firmicutes,25B6Y@186801|Clostridia,27THY@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_4056894_17	742733.HMPREF9469_04734	7.195e-41	169.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,21ZB9@1506553|Lachnoclostridium	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
CMS1_k127_4056894_15	1195236.CTER_2498	9.768e-74	271.0	COG2972@1|root,COG2972@2|Bacteria,1TPEB@1239|Firmicutes,24GC0@186801|Clostridia	186801|Clostridia	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase,dCache_1
CMS1_k127_4056894_2	158190.SpiGrapes_1828	1.171e-221	689.0	COG0657@1|root,COG0657@2|Bacteria,2J8DY@203691|Spirochaetes	203691|Spirochaetes	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
CMS1_k127_4056894_3	158190.SpiGrapes_1829	5.82e-188	589.0	COG1609@1|root,COG1609@2|Bacteria,2J6X6@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional Regulator, LacI	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_4056894_1	158190.SpiGrapes_1830	4.259e-241	748.0	COG1653@1|root,COG1653@2|Bacteria,2J75P@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
CMS1_k127_4056894_5	158190.SpiGrapes_1831	9.718e-156	497.0	COG1175@1|root,COG1175@2|Bacteria,2J5IT@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_4056894_6	158190.SpiGrapes_1832	1.798e-148	474.0	COG0395@1|root,COG0395@2|Bacteria,2J6AC@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10119	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_4056894_0	158190.SpiGrapes_1833	4.886e-321	994.0	COG1331@1|root,COG1331@2|Bacteria,2J5M5@203691|Spirochaetes	203691|Spirochaetes	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4056894_11	158190.SpiGrapes_1834	7.854e-124	401.0	COG3021@1|root,COG3021@2|Bacteria,2JBG0@203691|Spirochaetes	203691|Spirochaetes	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
CMS1_k127_4056894_12	158190.SpiGrapes_1835	4.585e-107	352.0	COG2755@1|root,COG2755@2|Bacteria,2J8DS@203691|Spirochaetes	203691|Spirochaetes	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS1_k127_4056894_18	158189.SpiBuddy_0093	0.0001422	45.0	COG1802@1|root,COG1802@2|Bacteria,2J7H2@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K22293	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_4056894_8	33035.JPJF01000054_gene1645	6.635e-137	443.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,25B0S@186801|Clostridia,3Y2DN@572511|Blautia	186801|Clostridia	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.380	ko:K08322	ko00040,ko01100,map00040,map01100	-	R10848	RC00085	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_4056894_9	658655.HMPREF0988_00728	4.662e-133	430.0	COG1172@1|root,COG1172@2|Bacteria,1V8JU@1239|Firmicutes,24E7P@186801|Clostridia	186801|Clostridia	U	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
CMS1_k127_4056894_10	658655.HMPREF0988_00729	1.147e-132	429.0	COG1129@1|root,COG1172@1|root,COG1129@2|Bacteria,COG1172@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,27IA2@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BPD_transp_2
CMS1_k127_4056914_9	1069080.KB913028_gene660	5.468e-54	209.0	COG2199@1|root,COG3706@2|Bacteria,1VADD@1239|Firmicutes,4H8UN@909932|Negativicutes	909932|Negativicutes	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,GGDEF,MASE3
CMS1_k127_4056914_2	1123274.KB899406_gene1140	9.046e-196	618.0	COG1914@1|root,COG1914@2|Bacteria,2J8YN@203691|Spirochaetes	203691|Spirochaetes	P	Natural resistance-associated macrophage protein	-	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
CMS1_k127_4056914_10	1123274.KB899406_gene1141	1.895e-41	161.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS1_k127_4056914_5	1462527.CCDM010000005_gene4949	2.757e-147	475.0	COG0620@1|root,COG0620@2|Bacteria,1TPDQ@1239|Firmicutes,4HADW@91061|Bacilli,23JZG@182709|Oceanobacillus	91061|Bacilli	E	Cobalamin-independent synthase, Catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
CMS1_k127_4056914_6	768704.Desmer_0588	2.583e-104	346.0	COG0583@1|root,COG0583@2|Bacteria,1TP3E@1239|Firmicutes,248HI@186801|Clostridia,260TG@186807|Peptococcaceae	186801|Clostridia	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS1_k127_4056914_0	158190.SpiGrapes_1701	0.0	1045.0	COG4666@1|root,COG4666@2|Bacteria,2J57Z@203691|Spirochaetes	2|Bacteria	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS1_k127_4056914_4	158190.SpiGrapes_1702	2.007e-183	577.0	COG2358@1|root,COG2358@2|Bacteria,2J705@203691|Spirochaetes	2|Bacteria	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
CMS1_k127_4056914_8	158190.SpiGrapes_1703	4.877e-69	235.0	COG1661@1|root,COG1661@2|Bacteria	2|Bacteria	O	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
CMS1_k127_4056914_1	158190.SpiGrapes_1704	4.69e-230	719.0	COG0446@1|root,COG0446@2|Bacteria,2J5NQ@203691|Spirochaetes	2|Bacteria	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	nox1	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
CMS1_k127_4056914_3	158190.SpiGrapes_1705	1.675e-194	607.0	COG0329@1|root,COG0329@2|Bacteria,2J5J6@203691|Spirochaetes	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA7	-	4.1.3.3,4.3.3.7	ko:K01639,ko:K01714	ko00261,ko00300,ko00520,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00520,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R01811,R10147	RC00159,RC00600,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS1_k127_4056914_7	158190.SpiGrapes_1706	2.264e-81	272.0	COG3681@1|root,COG3681@2|Bacteria,2J6AS@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0597 family	-	-	-	-	-	-	-	-	-	-	-	-	SDH_alpha
CMS1_k127_4068530_11	158190.SpiGrapes_1006	1.779e-68	234.0	COG2217@1|root,COG2217@2|Bacteria,2J60R@203691|Spirochaetes	203691|Spirochaetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	zntA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CMS1_k127_4068530_20	158190.SpiGrapes_1005	3.005e-30	120.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	copZ	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
CMS1_k127_4068530_5	1195236.CTER_0509	4.074e-89	297.0	COG1592@1|root,COG1592@2|Bacteria,1V1PW@1239|Firmicutes,25B8Q@186801|Clostridia	186801|Clostridia	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS1_k127_4068530_3	525309.HMPREF0494_1964	1.09e-103	347.0	COG3804@1|root,COG3804@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DapB_N
CMS1_k127_4068530_1	760011.Spico_1493	2.936e-150	485.0	COG0477@1|root,COG0477@2|Bacteria,2JBG8@203691|Spirochaetes	2|Bacteria	EGP	PFAM Major Facilitator Superfamily	yweA	-	-	ko:K08152	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
CMS1_k127_4068530_18	553184.ATORI0001_0043	3.603e-46	170.0	COG0454@1|root,COG0456@2|Bacteria,2HW7B@201174|Actinobacteria,4CY30@84998|Coriobacteriia	84998|Coriobacteriia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_4068530_16	411470.RUMGNA_01205	1.007e-56	203.0	COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,3XZUW@572511|Blautia	186801|Clostridia	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
CMS1_k127_4068530_15	545697.HMPREF0216_03361	6.404e-58	209.0	COG2059@1|root,COG2059@2|Bacteria,1V22C@1239|Firmicutes,24G7P@186801|Clostridia,36FDX@31979|Clostridiaceae	186801|Clostridia	P	overlaps another CDS with the same product name	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
CMS1_k127_4068530_10	1499684.CCNP01000023_gene3153	1.178e-69	246.0	COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia,36FHV@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS1_k127_4068530_7	931626.Awo_c16030	2.612e-75	264.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,25XMH@186806|Eubacteriaceae	186801|Clostridia	U	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
CMS1_k127_4068530_8	1121929.KB898667_gene3692	9.898e-74	257.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,4HBUK@91061|Bacilli	91061|Bacilli	V	abc transporter atp-binding protein	ybhF_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_4068530_13	158190.SpiGrapes_0995	2.13e-62	218.0	COG0801@1|root,COG0801@2|Bacteria,2J8EN@203691|Spirochaetes	203691|Spirochaetes	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
CMS1_k127_4068530_19	1195236.CTER_4613	6.997e-38	145.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,24MN5@186801|Clostridia	186801|Clostridia	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
CMS1_k127_4068530_2	158190.SpiGrapes_0993	9.386e-124	402.0	COG0294@1|root,COG0294@2|Bacteria,2J6FQ@203691|Spirochaetes	203691|Spirochaetes	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS1_k127_4068530_14	158190.SpiGrapes_0992	3.456e-59	209.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
CMS1_k127_4068530_4	158190.SpiGrapes_0991	7.249e-101	332.0	COG0302@1|root,COG0302@2|Bacteria,2J8DQ@203691|Spirochaetes	203691|Spirochaetes	H	GTP cyclohydrolase I	-	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
CMS1_k127_4068530_0	158190.SpiGrapes_0990	1.448e-304	940.0	COG0475@1|root,COG0475@2|Bacteria,2J603@203691|Spirochaetes	203691|Spirochaetes	GPT	PFAM Sodium hydrogen exchanger family	napA-1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
CMS1_k127_4068530_9	158190.SpiGrapes_0989	1.265e-70	241.0	COG1762@1|root,COG1762@2|Bacteria,2J7FM@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
CMS1_k127_4068530_6	158190.SpiGrapes_0988	4.988e-78	265.0	COG0494@1|root,COG0494@2|Bacteria,2JAK7@203691|Spirochaetes	203691|Spirochaetes	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
CMS1_k127_4068530_12	158190.SpiGrapes_0987	2.937e-63	220.0	COG3760@1|root,COG3760@2|Bacteria,2J6IV@203691|Spirochaetes	203691|Spirochaetes	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
CMS1_k127_4068530_17	158190.SpiGrapes_0986	4.701e-47	171.0	COG1403@1|root,COG1403@2|Bacteria,2J9QG@203691|Spirochaetes	203691|Spirochaetes	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_41509_0	158190.SpiGrapes_1473	3.145e-251	784.0	COG0659@1|root,COG0659@2|Bacteria,2J6EY@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Sulfate transporter family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
CMS1_k127_41509_1	158190.SpiGrapes_2398	6.04e-76	278.0	COG5001@1|root,COG5001@2|Bacteria,2J6TY@203691|Spirochaetes	203691|Spirochaetes	T	EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
CMS1_k127_41509_4	158190.SpiGrapes_2264	1.752e-19	105.0	COG0515@1|root,COG0515@2|Bacteria	158190.SpiGrapes_2264|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_41509_2	1123257.AUFV01000010_gene3349	3.691e-24	120.0	COG3292@1|root,COG3386@1|root,COG3292@2|Bacteria,COG3386@2|Bacteria,1N3BV@1224|Proteobacteria	1224|Proteobacteria	G	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
CMS1_k127_41509_3	158190.SpiGrapes_3234	8.673e-21	107.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	3.2.1.14,3.2.1.4	ko:K01179,ko:K01183	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R01206,R02334,R06200,R11307,R11308	RC00467	ko00000,ko00001,ko01000	-	GH18,GH5,GH9	-	CHB_HEX_C_1,DUF5074,Endonuclease_1,Glyco_hydro_18
CMS1_k127_4164355_0	158190.SpiGrapes_1434	4.846e-277	856.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,2J8HH@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
CMS1_k127_4164355_1	158190.SpiGrapes_1433	1.972e-262	816.0	COG2972@1|root,COG2972@2|Bacteria,2J80B@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
CMS1_k127_4164355_4	158190.SpiGrapes_1432	3.187e-201	629.0	COG1638@1|root,COG1638@2|Bacteria,2J5GS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
CMS1_k127_4164355_8	158190.SpiGrapes_1431	4.571e-83	278.0	COG3090@1|root,COG3090@2|Bacteria,2J8II@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	ko:K21394	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctQ
CMS1_k127_4164355_2	158190.SpiGrapes_1423	1.077e-237	747.0	COG1593@1|root,COG1593@2|Bacteria,2J6K2@203691|Spirochaetes	203691|Spirochaetes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS1_k127_4164355_3	158190.SpiGrapes_1422	5.83e-216	674.0	COG1454@1|root,COG1454@2|Bacteria,2J72Q@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS1_k127_4164355_7	158190.SpiGrapes_1421	3.315e-140	450.0	COG1349@1|root,COG1349@2|Bacteria,2J8GY@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, deoR family	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
CMS1_k127_4164355_6	158190.SpiGrapes_1420	2.677e-148	473.0	COG0434@1|root,COG0434@2|Bacteria	2|Bacteria	S	BtpA family	sgcQ	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
CMS1_k127_4164355_5	158190.SpiGrapes_1419	1.71e-192	603.0	COG1744@1|root,COG1744@2|Bacteria,2J6CM@203691|Spirochaetes	203691|Spirochaetes	S	basic membrane	bmpA-1	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
CMS1_k127_4168453_2	158190.SpiGrapes_3084	3.333e-24	103.0	COG1668@1|root,COG1668@2|Bacteria,2J992@203691|Spirochaetes	203691|Spirochaetes	CP	transmembrane transport	-	-	-	ko:K16906	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1	-	-	-
CMS1_k127_4168453_0	158190.SpiGrapes_3085	6.07e-150	477.0	COG1131@1|root,COG1131@2|Bacteria,2J7KQ@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K16907	ko02010,map02010	M00224	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_4168453_1	158190.SpiGrapes_3086	1.125e-85	288.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_4168453_3	1121864.OMO_01229	4.787e-18	89.0	COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,4HG13@91061|Bacilli,4AZ8G@81852|Enterococcaceae	91061|Bacilli	K	helix_turn_helix gluconate operon transcriptional repressor	rliB	-	-	-	-	-	-	-	-	-	-	-	GntR,Peripla_BP_3
CMS1_k127_4201654_1	158190.SpiGrapes_1836	1.505e-202	639.0	COG0366@1|root,COG0366@2|Bacteria,2J6F3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_4201654_4	760011.Spico_0492	4.146e-129	420.0	COG1609@1|root,COG1609@2|Bacteria,2J5CN@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, LacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_4201654_2	158190.SpiGrapes_1837	1.144e-180	580.0	COG0438@1|root,COG0438@2|Bacteria,2J6VH@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
CMS1_k127_4201654_3	158190.SpiGrapes_1838	7.963e-165	522.0	COG0395@1|root,COG0395@2|Bacteria,2JA0B@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_4201654_6	1104325.M7W_2676	1.247e-57	211.0	COG1175@1|root,COG1175@2|Bacteria,1TST8@1239|Firmicutes,4HFVM@91061|Bacilli,4B27M@81852|Enterococcaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_4201654_0	158190.SpiGrapes_1840	8.306e-262	812.0	COG1653@1|root,COG1653@2|Bacteria,2JA5C@203691|Spirochaetes	203691|Spirochaetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
CMS1_k127_4201654_7	158189.SpiBuddy_0087	7.682e-43	159.0	COG1846@1|root,COG1846@2|Bacteria,2JB9J@203691|Spirochaetes	203691|Spirochaetes	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4201654_5	158190.SpiGrapes_1842	8.322e-128	411.0	COG0425@1|root,COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0425@2|Bacteria,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2J5NQ@203691|Spirochaetes	203691|Spirochaetes	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
CMS1_k127_421412_14	158190.SpiGrapes_2649	1.479e-65	226.0	COG3836@1|root,COG3836@2|Bacteria,2JAZS@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
CMS1_k127_421412_9	158190.SpiGrapes_2650	3.205e-113	369.0	COG2186@1|root,COG2186@2|Bacteria,2J7JW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_421412_12	1216932.CM240_2881	6.731e-76	258.0	COG0454@1|root,COG0456@2|Bacteria,1V8DY@1239|Firmicutes,24I09@186801|Clostridia,36JA0@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_421412_10	158190.SpiGrapes_2651	2.91e-93	311.0	COG1355@1|root,COG1355@2|Bacteria,2J7WY@203691|Spirochaetes	203691|Spirochaetes	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
CMS1_k127_421412_17	158190.SpiGrapes_2651	3.887e-23	100.0	COG1355@1|root,COG1355@2|Bacteria,2J7WY@203691|Spirochaetes	203691|Spirochaetes	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
CMS1_k127_421412_13	158190.SpiGrapes_2652	4.823e-66	230.0	COG2078@1|root,COG2078@2|Bacteria,2J7B9@203691|Spirochaetes	203691|Spirochaetes	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
CMS1_k127_421412_7	158190.SpiGrapes_2653	4.131e-145	465.0	COG1180@1|root,COG1180@2|Bacteria,2J5WE@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_421412_16	158190.SpiGrapes_2654	2.536e-30	121.0	COG4895@1|root,COG4895@2|Bacteria,2JB6B@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized conserved protein (DUF2196)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2196
CMS1_k127_421412_1	158190.SpiGrapes_2655	4.326e-301	929.0	COG0488@1|root,COG0488@2|Bacteria,2JA3A@203691|Spirochaetes	203691|Spirochaetes	S	ATPase component of ABC transporters with duplicated ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
CMS1_k127_421412_15	158190.SpiGrapes_2656	4.93e-65	224.0	COG1433@1|root,COG1433@2|Bacteria,2JBGQ@203691|Spirochaetes	203691|Spirochaetes	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
CMS1_k127_421412_11	158190.SpiGrapes_2657	4.531e-77	261.0	COG0041@1|root,COG0041@2|Bacteria,2J8QD@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
CMS1_k127_421412_8	158190.SpiGrapes_2658	1.526e-129	417.0	COG0152@1|root,COG0152@2|Bacteria,2J6AW@203691|Spirochaetes	203691|Spirochaetes	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
CMS1_k127_421412_2	158190.SpiGrapes_2659	2.454e-288	888.0	COG0034@1|root,COG0034@2|Bacteria,2J5Y2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
CMS1_k127_421412_6	158189.SpiBuddy_2153	1.257e-146	472.0	COG0150@1|root,COG0150@2|Bacteria,2J5AP@203691|Spirochaetes	203691|Spirochaetes	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS1_k127_421412_5	158190.SpiGrapes_2661	1.721e-200	631.0	COG0299@1|root,COG3363@1|root,COG0299@2|Bacteria,COG3363@2|Bacteria,2J5P7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,IMP_cyclohyd
CMS1_k127_421412_3	158190.SpiGrapes_2662	3.667e-226	703.0	COG0138@1|root,COG0138@2|Bacteria,2J6Y2@203691|Spirochaetes	203691|Spirochaetes	F	COGs COG0138 AICAR transformylase IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	-	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas
CMS1_k127_421412_4	158190.SpiGrapes_2663	1.474e-207	651.0	COG0151@1|root,COG0151@2|Bacteria,2J5WP@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the GARS family	purD	-	6.3.2.6,6.3.4.13	ko:K01945,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,GARS_A,GARS_C,GARS_N
CMS1_k127_421412_0	158190.SpiGrapes_2664	0.0	1746.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,2J66J@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
CMS1_k127_421736_0	158190.SpiGrapes_0558	3.191e-193	608.0	COG0470@1|root,COG0470@2|Bacteria,2JBGE@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
CMS1_k127_421736_1	158190.SpiGrapes_0560	1.347e-120	394.0	COG0707@1|root,COG0707@2|Bacteria,2J5XF@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
CMS1_k127_424533_8	158190.SpiGrapes_3242	2.199e-140	452.0	COG2221@1|root,COG2221@2|Bacteria,2J8QB@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr
CMS1_k127_424533_9	158190.SpiGrapes_3243	5.564e-123	401.0	COG0583@1|root,COG0583@2|Bacteria,2J6T1@203691|Spirochaetes	203691|Spirochaetes	K	LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS1_k127_424533_1	158190.SpiGrapes_3244	1.71e-321	990.0	COG1022@1|root,COG1022@2|Bacteria,2J65F@203691|Spirochaetes	203691|Spirochaetes	I	Long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
CMS1_k127_424533_10	158190.SpiGrapes_3245	1.851e-55	195.0	COG1534@1|root,COG1534@2|Bacteria,2J8BU@203691|Spirochaetes	203691|Spirochaetes	J	PFAM CRS1 YhbY (CRM) domain	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
CMS1_k127_424533_3	158190.SpiGrapes_3246	6.868e-249	777.0	COG3525@1|root,COG3525@2|Bacteria,2J6G1@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolase family 20, catalytic domain	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	Glyco_hydro_20,Glyco_hydro_20b
CMS1_k127_424533_4	158190.SpiGrapes_3247	1.765e-237	738.0	COG1940@1|root,COG1940@2|Bacteria,2J5IZ@203691|Spirochaetes	203691|Spirochaetes	K	pfam rok	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
CMS1_k127_424533_6	158190.SpiGrapes_3248	1.737e-172	544.0	COG1175@1|root,COG1175@2|Bacteria,2J71Z@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_424533_7	158190.SpiGrapes_3249	3.136e-157	499.0	COG0395@1|root,COG0395@2|Bacteria,2J5WH@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_424533_2	158190.SpiGrapes_3250	3.086e-259	802.0	COG1653@1|root,COG1653@2|Bacteria,2J5WB@203691|Spirochaetes	203691|Spirochaetes	G	bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
CMS1_k127_424533_0	158190.SpiGrapes_3251	0.0	1473.0	COG3250@1|root,COG3250@2|Bacteria,2J6W2@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolases family 2	-	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2
CMS1_k127_424533_5	158190.SpiGrapes_3252	4.427e-190	600.0	COG0667@1|root,COG0667@2|Bacteria,2J6C3@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Aldo keto reductase family	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
CMS1_k127_425308_0	760011.Spico_0384	0.0	1284.0	COG1874@1|root,COG5520@1|root,COG1874@2|Bacteria,COG5520@2|Bacteria	2|Bacteria	M	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.23,3.2.1.46	ko:K01190,ko:K01202,ko:K12308	ko00052,ko00511,ko00600,ko01100,ko04142,map00052,map00511,map00600,map01100,map04142	-	R01105,R01678,R03355,R03617,R04783,R06114	RC00049,RC00059,RC00451,RC00452	ko00000,ko00001,ko01000	-	GH59	-	Cellulase,Glyco_hydro_42,Glyco_hydro_42M,Glyco_hydro_59,Glyco_hydro_59M,Laminin_G_3,RicinB_lectin_2,Ricin_B_lectin
CMS1_k127_425308_1	760011.Spico_0385	1.685e-288	891.0	COG1653@1|root,COG1653@2|Bacteria,2J8BG@203691|Spirochaetes	203691|Spirochaetes	G	bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1,SBP_bac_8
CMS1_k127_425308_2	760011.Spico_0386	7.667e-45	164.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	mltR	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
CMS1_k127_42720_4	1236976.JCM16418_1704	6.212e-48	179.0	COG1653@1|root,COG1653@2|Bacteria,1UYSZ@1239|Firmicutes,4HEMH@91061|Bacilli,26S1G@186822|Paenibacillaceae	91061|Bacilli	G	Extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
CMS1_k127_42720_3	1236976.JCM16418_1703	8.364e-59	215.0	COG1175@1|root,COG1175@2|Bacteria,1TRC0@1239|Firmicutes,4HFEK@91061|Bacilli,26QVA@186822|Paenibacillaceae	91061|Bacilli	G	COG1175 ABC-type sugar transport systems, permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_42720_2	1236976.JCM16418_1702	3.725e-59	216.0	COG0395@1|root,COG0395@2|Bacteria,1TPIF@1239|Firmicutes,4HE61@91061|Bacilli,26Q9R@186822|Paenibacillaceae	91061|Bacilli	P	Sugar ABC transporter ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_42720_1	665956.HMPREF1032_00414	4.671e-82	277.0	COG2256@1|root,COG2256@2|Bacteria,1TXDS@1239|Firmicutes,24EUP@186801|Clostridia	186801|Clostridia	L	MgsA AAA+ ATPase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MgsA_C
CMS1_k127_42720_0	1211819.CALK01000007_gene2625	5.284e-94	321.0	COG1524@1|root,COG1524@2|Bacteria,1TRZ7@1239|Firmicutes,3VSEH@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
CMS1_k127_429307_0	411902.CLOBOL_06627	9.912e-144	466.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,21Y3W@1506553|Lachnoclostridium	186801|Clostridia	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
CMS1_k127_429307_1	1345695.CLSA_c03480	1.206e-25	108.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,36FGA@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	etfB1	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
CMS1_k127_43013_2	1196323.ALKF01000148_gene1411	2.776e-19	91.0	COG2207@1|root,COG2207@2|Bacteria,1V2SW@1239|Firmicutes,4HEW6@91061|Bacilli	91061|Bacilli	K	COG2207 AraC-type DNA-binding domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Peripla_BP_2
CMS1_k127_43013_0	33035.JPJF01000019_gene4234	3.468e-88	299.0	COG0395@1|root,COG0395@2|Bacteria,1V5TP@1239|Firmicutes,24IWF@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_43013_1	33035.JPJF01000019_gene4233	1.549e-61	216.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AHK@186801|Clostridia,3XZH7@572511|Blautia	186801|Clostridia	G	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_4308326_3	158190.SpiGrapes_1870	2.546e-165	522.0	COG1253@1|root,COG1253@2|Bacteria,2J7S9@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1253 Hemolysins and related protein containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
CMS1_k127_4308326_0	158190.SpiGrapes_1871	0.0	1624.0	COG0495@1|root,COG0495@2|Bacteria,2J5BV@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
CMS1_k127_4308326_4	158190.SpiGrapes_1872	2.912e-131	422.0	COG0584@1|root,COG0584@2|Bacteria,2J689@203691|Spirochaetes	203691|Spirochaetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS1_k127_4308326_5	663278.Ethha_1512	1.289e-112	369.0	COG0730@1|root,COG0730@2|Bacteria,1TRFG@1239|Firmicutes,24AEX@186801|Clostridia,3WH0U@541000|Ruminococcaceae	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS1_k127_4308326_7	693746.OBV_05530	1.617e-86	289.0	COG1309@1|root,COG1309@2|Bacteria,1V7DY@1239|Firmicutes,25DSB@186801|Clostridia	186801|Clostridia	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
CMS1_k127_4308326_2	158190.SpiGrapes_1879	5.984e-241	747.0	COG1760@1|root,COG1760@2|Bacteria,2J6H3@203691|Spirochaetes	203691|Spirochaetes	E	L-serine dehydratase, iron-sulfur-dependent	sdaA	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
CMS1_k127_4308326_9	158190.SpiGrapes_1881	3.024e-77	262.0	2CA4A@1|root,32RQK@2|Bacteria,2J92B@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
CMS1_k127_4308326_1	158190.SpiGrapes_1882	0.0	1155.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,2J644@203691|Spirochaetes	203691|Spirochaetes	H	PFAM DAHP synthetase I KDSA	pheA	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,DAHP_synth_1,PDT
CMS1_k127_4308326_6	158190.SpiGrapes_1883	2.8e-106	357.0	COG0177@1|root,COG0177@2|Bacteria,2J7HG@203691|Spirochaetes	203691|Spirochaetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
CMS1_k127_4308460_1	158190.SpiGrapes_2185	3.618e-213	666.0	COG1774@1|root,COG1774@2|Bacteria,2J5RE@203691|Spirochaetes	203691|Spirochaetes	S	PFAM PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
CMS1_k127_4308460_3	158190.SpiGrapes_2184	7.716e-154	488.0	COG0084@1|root,COG0084@2|Bacteria,2J68W@203691|Spirochaetes	203691|Spirochaetes	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS1_k127_4308460_2	158190.SpiGrapes_2183	2.82e-169	536.0	COG0042@1|root,COG0042@2|Bacteria,2J691@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
CMS1_k127_4308460_0	158190.SpiGrapes_2182	1.315e-214	668.0	COG0151@1|root,COG0151@2|Bacteria,2J9IF@203691|Spirochaetes	203691|Spirochaetes	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	-	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
CMS1_k127_431129_0	158190.SpiGrapes_1857	0.0	2277.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,2J5QV@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
CMS1_k127_431129_4	158190.SpiGrapes_1858	6.715e-201	632.0	COG0477@1|root,COG2814@2|Bacteria,2JA5Q@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
CMS1_k127_431129_1	158190.SpiGrapes_1859	0.0	1598.0	COG0209@1|root,COG0209@2|Bacteria,2J5M3@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN
CMS1_k127_431129_5	158190.SpiGrapes_1860	2.796e-81	276.0	2CET8@1|root,2Z7N2@2|Bacteria	2|Bacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_431129_3	158190.SpiGrapes_1861	4.133e-271	837.0	COG0334@1|root,COG0334@2|Bacteria,2J9YS@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
CMS1_k127_431129_2	158190.SpiGrapes_1862	0.0	1587.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,2J6KN@203691|Spirochaetes	203691|Spirochaetes	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS1_k127_4374508_3	1178482.BJB45_17395	2.865e-12	70.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter TctA	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
CMS1_k127_4374508_1	1123274.KB899427_gene3322	2.277e-121	394.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	gtsC	-	-	ko:K02026,ko:K17317	ko02010,map02010	M00207,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
CMS1_k127_4374508_0	573413.Spirs_3062	3.005e-139	447.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	gtsB	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K15771,ko:K17235,ko:K17238,ko:K17316	ko02010,map02010	M00196,M00198,M00204,M00207,M00491,M00599,M00602,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34,3.A.1.1.38	-	-	BPD_transp_1
CMS1_k127_4374508_2	573413.Spirs_3061	2.544e-73	249.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	gtsA	-	-	ko:K17315	ko02010,map02010	M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.24,3.A.1.1.30	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_4450004_1	158190.SpiGrapes_1483	7.192e-147	469.0	COG0560@1|root,COG0560@2|Bacteria,2J5Y5@203691|Spirochaetes	203691|Spirochaetes	E	Phosphoserine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CMS1_k127_4450004_0	158190.SpiGrapes_1478	6.165e-211	661.0	COG0371@1|root,COG0371@2|Bacteria,2J7JG@203691|Spirochaetes	203691|Spirochaetes	C	PFAM 3-dehydroquinate synthase	-	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
CMS1_k127_4450004_5	158190.SpiGrapes_1477	1.971e-59	216.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4450004_6	665956.HMPREF1032_03542	3.079e-30	122.0	COG4737@1|root,COG4737@2|Bacteria,1VHTW@1239|Firmicutes,24SS0@186801|Clostridia	186801|Clostridia	S	RelE toxin of RelE / RelB toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	RelE
CMS1_k127_4450004_7	1307761.L21SP2_1478	3.955e-18	91.0	COG2944@1|root,COG2944@2|Bacteria,2J8YE@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
CMS1_k127_4450004_3	158189.SpiBuddy_0500	4.779e-85	290.0	2DBRG@1|root,2ZAKM@2|Bacteria,2J7DV@203691|Spirochaetes	203691|Spirochaetes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4450004_2	158190.SpiGrapes_1475	1.054e-109	362.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	folD4	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
CMS1_k127_4450004_4	158190.SpiGrapes_1474	4.026e-63	220.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	gloA	-	4.4.1.5	ko:K01759,ko:K15772	ko00620,ko02010,map00620,map02010	M00491	R02530	RC00004,RC00740	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	Glyoxalase
CMS1_k127_4469344_6	1122918.KB907267_gene60	1.549e-74	256.0	COG0395@1|root,COG0395@2|Bacteria,1TPIF@1239|Firmicutes,4HBYY@91061|Bacilli,274ND@186822|Paenibacillaceae	91061|Bacilli	P	Sugar ABC transporter ATP-binding protein	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_4469344_0	1122919.KB905569_gene2971	1.337e-179	578.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,26TD5@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
CMS1_k127_4469344_7	1268072.PSAB_08295	2.022e-65	230.0	COG0637@1|root,COG0637@2|Bacteria,1UZE0@1239|Firmicutes,4HFTF@91061|Bacilli,26RPY@186822|Paenibacillaceae	91061|Bacilli	S	beta-phosphoglucomutase	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_4469344_3	658655.HMPREF0988_01099	9.087e-112	379.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,27RHW@186928|unclassified Lachnospiraceae	186801|Clostridia	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17,2.7.1.30	ko:K00854,ko:K00864	ko00040,ko00561,ko01100,ko03320,ko04626,map00040,map00561,map01100,map03320,map04626	M00014	R00847,R01639	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
CMS1_k127_4469344_2	1121115.AXVN01000038_gene3343	3.175e-114	378.0	28IPH@1|root,2Z8PG@2|Bacteria,1TREB@1239|Firmicutes,248QM@186801|Clostridia,3Y18D@572511|Blautia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4469344_4	411470.RUMGNA_02537	3.665e-109	359.0	COG3623@1|root,COG3623@2|Bacteria,1TSMS@1239|Firmicutes,247T6@186801|Clostridia,3Y1CM@572511|Blautia	186801|Clostridia	G	Xylose isomerase-like TIM barrel	ulaE	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
CMS1_k127_4469344_9	478749.BRYFOR_08164	7.9e-18	87.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia	186801|Clostridia	G	L-ribulose-5-phosphate 4-epimerase	-	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
CMS1_k127_4469344_1	445972.ANACOL_00928	9.59e-153	490.0	COG1373@1|root,COG1373@2|Bacteria,1TPFF@1239|Firmicutes,24A52@186801|Clostridia,3WH6C@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS1_k127_4469344_5	580327.Tthe_1727	1.427e-83	288.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,42EQH@68295|Thermoanaerobacterales	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	rbsR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_4469344_8	1232452.BAIB02000006_gene1404	1.678e-21	96.0	COG1879@1|root,COG1879@2|Bacteria,1TRBC@1239|Firmicutes,24P85@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
CMS1_k127_4470109_5	1226325.HMPREF1548_01069	1.755e-50	184.0	COG3871@1|root,COG3871@2|Bacteria,1V1KZ@1239|Firmicutes,25CPA@186801|Clostridia,36WYN@31979|Clostridiaceae	186801|Clostridia	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx,Pyrid_ox_like
CMS1_k127_4470109_1	158190.SpiGrapes_2913	8.775e-268	829.0	COG0165@1|root,COG0165@2|Bacteria,2J5FG@203691|Spirochaetes	203691|Spirochaetes	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
CMS1_k127_4470109_2	158190.SpiGrapes_2912	3.017e-117	386.0	2EVQY@1|root,33P4X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4470109_3	350688.Clos_2850	8.109e-92	310.0	28J14@1|root,2Z8Y5@2|Bacteria,1US7S@1239|Firmicutes,24FFV@186801|Clostridia,36RJK@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4470109_6	1227352.C173_05016	4.588e-10	66.0	28J14@1|root,2Z8Y5@2|Bacteria,1US7S@1239|Firmicutes,4I6M0@91061|Bacilli,26TN4@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4470109_4	158190.SpiGrapes_2911	3.728e-56	196.0	COG3118@1|root,COG3118@2|Bacteria,2J865@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS1_k127_4470109_0	760011.Spico_0386	0.0	1013.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	mltR	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
CMS1_k127_4479573_0	33035.JPJF01000040_gene5178	2.318e-121	398.0	COG1940@1|root,COG1940@2|Bacteria,1TRGJ@1239|Firmicutes,248TJ@186801|Clostridia,3Y148@572511|Blautia	186801|Clostridia	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
CMS1_k127_4479573_2	1033734.CAET01000005_gene3750	4.554e-58	211.0	COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,4HH1R@91061|Bacilli,1ZICD@1386|Bacillus	91061|Bacilli	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
CMS1_k127_4479573_1	33035.JPJF01000040_gene5183	4.67e-92	310.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,24AE3@186801|Clostridia,3Y1MA@572511|Blautia	186801|Clostridia	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
CMS1_k127_4480746_4	158190.SpiGrapes_3050	5.415e-92	307.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,Peptidase_C13,Peptidase_C14
CMS1_k127_4480746_8	913865.DOT_1968	5.8e-38	145.0	COG3070@1|root,COG3070@2|Bacteria,1VAD4@1239|Firmicutes,25CQQ@186801|Clostridia	186801|Clostridia	K	TfoX, N-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
CMS1_k127_4480746_7	1232453.BAIF02000019_gene3941	2.652e-62	224.0	COG0500@1|root,COG2226@2|Bacteria,1TR4Y@1239|Firmicutes,24DHJ@186801|Clostridia	186801|Clostridia	Q	Methyltransferase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS1_k127_4480746_6	158189.SpiBuddy_1914	9.337e-70	248.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Peptidase_C14,WD40
CMS1_k127_4480746_0	158190.SpiGrapes_3048	0.0	1243.0	COG0556@1|root,COG0556@2|Bacteria,2J57B@203691|Spirochaetes	203691|Spirochaetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CMS1_k127_4480746_1	158190.SpiGrapes_3047	1.078e-227	710.0	COG0265@1|root,COG0265@2|Bacteria,2J6JY@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
CMS1_k127_4480746_2	158190.SpiGrapes_3046	3.411e-165	524.0	COG0524@1|root,COG0524@2|Bacteria,2J6UQ@203691|Spirochaetes	203691|Spirochaetes	G	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS1_k127_4480746_3	158190.SpiGrapes_3045	9.576e-151	484.0	COG3294@1|root,COG3294@2|Bacteria,2J5Z4@203691|Spirochaetes	203691|Spirochaetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	-
CMS1_k127_4480746_9	158190.SpiGrapes_3043	1.391e-16	80.0	COG0008@1|root,COG0008@2|Bacteria,2J6KU@203691|Spirochaetes	203691|Spirochaetes	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
CMS1_k127_4486196_19	158189.SpiBuddy_2765	2.173e-05	48.0	COG1121@1|root,COG1121@2|Bacteria,2J6HR@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	znuC	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
CMS1_k127_4486196_14	158190.SpiGrapes_2229	3.833e-153	490.0	COG1108@1|root,COG1108@2|Bacteria,2J798@203691|Spirochaetes	203691|Spirochaetes	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
CMS1_k127_4486196_18	158190.SpiGrapes_2230	2.93e-56	205.0	COG0735@1|root,COG0735@2|Bacteria,2J7I1@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS1_k127_4486196_1	158190.SpiGrapes_2231	0.0	1227.0	COG1274@1|root,COG1274@2|Bacteria,2J5BB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
CMS1_k127_4486196_9	158190.SpiGrapes_2232	3.52e-219	687.0	COG0534@1|root,COG0534@2|Bacteria,2J6H0@203691|Spirochaetes	203691|Spirochaetes	V	PFAM multi antimicrobial extrusion protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_4486196_15	158190.SpiGrapes_2237	2.883e-145	466.0	COG2197@1|root,COG2197@2|Bacteria,2J9AC@203691|Spirochaetes	203691|Spirochaetes	KT	transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS1_k127_4486196_16	158190.SpiGrapes_2239	1.255e-95	323.0	COG2834@1|root,COG2834@2|Bacteria,2JBH0@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS1_k127_4486196_3	158190.SpiGrapes_2240	0.0	1018.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS1_k127_4486196_8	158190.SpiGrapes_2241	1.077e-222	697.0	COG0366@1|root,COG0366@2|Bacteria,2J6JB@203691|Spirochaetes	203691|Spirochaetes	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Malt_amylase_C
CMS1_k127_4486196_17	158190.SpiGrapes_2242	1.523e-87	295.0	COG1309@1|root,COG1309@2|Bacteria,2J5WM@203691|Spirochaetes	203691|Spirochaetes	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_4486196_5	158190.SpiGrapes_2243	2.366e-262	814.0	COG0469@1|root,COG0469@2|Bacteria,2J5VE@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
CMS1_k127_4486196_7	158190.SpiGrapes_2244	9.53e-229	713.0	COG0836@1|root,COG0836@2|Bacteria,2J6ST@203691|Spirochaetes	203691|Spirochaetes	M	mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
CMS1_k127_4486196_6	158190.SpiGrapes_2245	4.8e-257	797.0	2CK74@1|root,33FA9@2|Bacteria	2|Bacteria	S	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
CMS1_k127_4486196_4	158190.SpiGrapes_2246	3.509e-280	866.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	MatE,Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
CMS1_k127_4486196_2	158190.SpiGrapes_2247	0.0	1201.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	3.1.21.3	ko:K01153,ko:K05789,ko:K07011,ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01005,ko02000,ko02048	8.A.3.1	-	-	GNVR,Wzz
CMS1_k127_4486196_0	158190.SpiGrapes_2248	0.0	1375.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbW	-	2.4.1.12,3.1.3.3	ko:K00694,ko:K07315	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000,ko03021	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	HATPase_c_2,MatE,PAS_4,Response_reg,SpoIIE
CMS1_k127_4486196_11	158190.SpiGrapes_2249	2.087e-194	615.0	COG0438@1|root,COG0438@2|Bacteria,2JAVP@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS1_k127_4486196_12	158190.SpiGrapes_2250	1.145e-177	569.0	COG5653@1|root,COG5653@2|Bacteria	2|Bacteria	M	Protein involved in cellulose biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
CMS1_k127_4486196_10	158190.SpiGrapes_2251	1.102e-197	631.0	COG5653@1|root,COG5653@2|Bacteria	2|Bacteria	M	Protein involved in cellulose biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
CMS1_k127_448991_2	158190.SpiGrapes_0900	2.59e-105	344.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS1_k127_448991_4	768706.Desor_4481	1.154e-64	228.0	COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,260Y2@186807|Peptococcaceae	186801|Clostridia	S	PFAM HD domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
CMS1_k127_448991_0	158190.SpiGrapes_0898	0.0	1498.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2J727@203691|Spirochaetes	203691|Spirochaetes	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
CMS1_k127_448991_3	693746.OBV_12110	3.982e-103	346.0	COG2005@1|root,COG2068@1|root,COG2005@2|Bacteria,COG2068@2|Bacteria,1VFW6@1239|Firmicutes,24QTV@186801|Clostridia	186801|Clostridia	S	Transcriptional regulator, LysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,NTP_transf_3
CMS1_k127_448991_1	158190.SpiGrapes_0896	1.829e-141	452.0	COG0474@1|root,COG0474@2|Bacteria,2J78K@203691|Spirochaetes	203691|Spirochaetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL2	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
CMS1_k127_4511572_0	158190.SpiGrapes_0199	0.0	1435.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2J5W1@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
CMS1_k127_4511572_2	158189.SpiBuddy_1592	4.906e-264	826.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6JA@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Iron only hydrogenase large subunit, C-terminal domain	-	-	1.12.1.3,1.17.99.7,1.6.5.3	ko:K00336,ko:K18332,ko:K22015	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
CMS1_k127_4511572_1	158190.SpiGrapes_2925	0.0	1257.0	COG1166@1|root,COG1166@2|Bacteria,2J9X5@203691|Spirochaetes	203691|Spirochaetes	H	arginine decarboxylase	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
CMS1_k127_4511572_3	158190.SpiGrapes_2926	8.864e-257	792.0	COG1748@1|root,COG1748@2|Bacteria,2J9PA@203691|Spirochaetes	203691|Spirochaetes	E	Saccharopine dehydrogenase	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
CMS1_k127_4511572_7	1147.D082_22040	1.38e-117	389.0	COG0019@1|root,COG0019@2|Bacteria,1G4FF@1117|Cyanobacteria,1H65B@1142|Synechocystis	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase, C-terminal sheet domain	napC	-	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_DAP_Arg_deC
CMS1_k127_4511572_6	158190.SpiGrapes_2928	7.024e-175	550.0	COG0010@1|root,COG0010@2|Bacteria,2J938@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
CMS1_k127_4511572_11	1125700.HMPREF9195_00756	2.1e-22	99.0	COG2929@1|root,COG2929@2|Bacteria,2J923@203691|Spirochaetes	203691|Spirochaetes	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
CMS1_k127_4511572_14	998674.ATTE01000001_gene3803	1.226e-09	64.0	COG3514@1|root,COG3514@2|Bacteria,1N6WF@1224|Proteobacteria,1SF2J@1236|Gammaproteobacteria,46358@72273|Thiotrichales	72273|Thiotrichales	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin
CMS1_k127_4511572_12	1321815.HMPREF9193_01990	6.487e-22	97.0	COG2026@1|root,COG2026@2|Bacteria,2J8RG@203691|Spirochaetes	203691|Spirochaetes	DJ	addiction module toxin, RelE StbE family	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
CMS1_k127_4511572_13	1158182.KB905024_gene50	9.67e-11	65.0	COG4710@1|root,COG4710@2|Bacteria,1N6PY@1224|Proteobacteria,1SDNK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CopG domain protein DNA-binding domain protein	-	-	-	ko:K18918	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1
CMS1_k127_4511572_9	158190.SpiGrapes_2930	5.391e-81	270.0	COG0432@1|root,COG0432@2|Bacteria,2J7PN@203691|Spirochaetes	203691|Spirochaetes	S	Secondary thiamine-phosphate synthase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS1_k127_4511572_8	158190.SpiGrapes_2931	2.335e-104	347.0	COG0697@1|root,COG0697@2|Bacteria,2J5K6@203691|Spirochaetes	203691|Spirochaetes	EG	EamA-like transporter family	ybfH	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS1_k127_4511572_5	158190.SpiGrapes_2932	9.837e-208	651.0	COG4277@1|root,COG4277@2|Bacteria,2J6DM@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4511572_10	158190.SpiGrapes_2934	1.859e-71	244.0	COG3467@1|root,COG3467@2|Bacteria,2J8YB@203691|Spirochaetes	203691|Spirochaetes	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
CMS1_k127_4511572_4	158190.SpiGrapes_2935	3.301e-238	755.0	COG3012@1|root,COG3266@1|root,COG3012@2|Bacteria,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	GO:0005575,GO:0005623,GO:0030115,GO:0030312,GO:0044464,GO:0071944	2.7.11.1	ko:K12132,ko:K21471	-	-	-	-	ko00000,ko01000,ko01001,ko01002,ko01011	-	-	-	-
CMS1_k127_4512211_1	158190.SpiGrapes_0421	2.27e-111	361.0	COG0036@1|root,COG0036@2|Bacteria,2J7B7@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
CMS1_k127_4512211_2	158190.SpiGrapes_0422	1.776e-69	237.0	COG1490@1|root,COG1490@2|Bacteria,2J8PS@203691|Spirochaetes	203691|Spirochaetes	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
CMS1_k127_4512211_0	158190.SpiGrapes_0423	5.9e-216	672.0	COG0468@1|root,COG0468@2|Bacteria,2J5G5@203691|Spirochaetes	203691|Spirochaetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
CMS1_k127_4512211_3	158190.SpiGrapes_0424	2.047e-63	221.0	COG1354@1|root,COG1354@2|Bacteria,2J5RF@203691|Spirochaetes	203691|Spirochaetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
CMS1_k127_4517516_0	158189.SpiBuddy_2581	0.0	1506.0	COG0454@1|root,COG2203@1|root,COG4191@1|root,COG0456@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2J9V6@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,HATPase_c,HisKA,PAS,PAS_9,Response_reg
CMS1_k127_4517516_4	158190.SpiGrapes_2368	8.633e-64	226.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS1_k127_4517516_1	158190.SpiGrapes_2367	7.136e-167	529.0	COG3437@1|root,COG3437@2|Bacteria,2JBGT@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
CMS1_k127_4517516_2	158190.SpiGrapes_2351	1.779e-130	422.0	2EBXX@1|root,335X9@2|Bacteria,2J6WG@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4517516_3	158190.SpiGrapes_2340	1.242e-71	245.0	COG0664@1|root,COG0664@2|Bacteria,2J886@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
CMS1_k127_4517516_5	1499967.BAYZ01000159_gene536	0.0001614	44.0	COG3384@1|root,COG3384@2|Bacteria	2|Bacteria	S	3-carboxyethylcatechol 2,3-dioxygenase activity	-	-	1.13.11.8	ko:K04100	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
CMS1_k127_4531286_3	158190.SpiGrapes_1739	1.751e-149	475.0	COG0411@1|root,COG0411@2|Bacteria,2J67E@203691|Spirochaetes	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
CMS1_k127_4531286_1	158190.SpiGrapes_1740	1.326e-181	572.0	COG4177@1|root,COG4177@2|Bacteria	2|Bacteria	E	L-phenylalanine transmembrane transporter activity	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS1_k127_4531286_2	158190.SpiGrapes_1741	1.944e-174	548.0	COG0559@1|root,COG0559@2|Bacteria,2J64W@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS1_k127_4531286_0	158190.SpiGrapes_1742	9.815e-236	731.0	COG0683@1|root,COG0683@2|Bacteria,2JADP@203691|Spirochaetes	203691|Spirochaetes	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS1_k127_4531286_4	158190.SpiGrapes_1743	2.929e-89	295.0	299ND@1|root,2ZBPX@2|Bacteria,2JBFV@203691|Spirochaetes	203691|Spirochaetes	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
CMS1_k127_4561135_7	158190.SpiGrapes_0972	2.603e-128	413.0	COG0395@1|root,COG0395@2|Bacteria,2J7VD@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter, permease protein	-	-	-	ko:K02026,ko:K17246	ko02010,map02010	M00207,M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.40	-	-	BPD_transp_1
CMS1_k127_4561135_4	158190.SpiGrapes_0973	3.721e-177	558.0	COG1175@1|root,COG1175@2|Bacteria,2J5Q4@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_4561135_2	158190.SpiGrapes_0974	2.496e-246	764.0	COG1653@1|root,COG1653@2|Bacteria,2J5AA@203691|Spirochaetes	203691|Spirochaetes	G	solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_4561135_3	158190.SpiGrapes_0975	1.433e-198	621.0	COG1609@1|root,COG1609@2|Bacteria,2J657@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_4561135_0	158190.SpiGrapes_0976	0.0	1172.0	COG1554@1|root,COG1554@2|Bacteria,2J6TA@203691|Spirochaetes	2|Bacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.230,2.4.1.282	ko:K10231,ko:K18784	-	-	-	-	ko00000,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
CMS1_k127_4561135_5	699246.HMPREF0868_0807	2.185e-170	554.0	COG3538@1|root,COG3538@2|Bacteria,1TRJI@1239|Firmicutes,248YF@186801|Clostridia,26ABT@186813|unclassified Clostridiales	186801|Clostridia	S	Pfam:DUF1237	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_125
CMS1_k127_4561135_10	158190.SpiGrapes_0978	4.819e-80	270.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
CMS1_k127_4561135_1	158190.SpiGrapes_0979	5.18e-301	930.0	COG1132@1|root,COG1132@2|Bacteria,2J5E3@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS1_k127_4561135_8	1226325.HMPREF1548_03252	3.555e-126	424.0	COG1132@1|root,COG1132@2|Bacteria,1TPTK@1239|Firmicutes,249W7@186801|Clostridia,36E6W@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS1_k127_4561135_6	158190.SpiGrapes_0981	3.285e-139	447.0	COG0657@1|root,COG0657@2|Bacteria,2J66M@203691|Spirochaetes	203691|Spirochaetes	I	Alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
CMS1_k127_4561135_12	158190.SpiGrapes_0984	2.502e-21	98.0	COG1396@1|root,COG1396@2|Bacteria,2J8UK@203691|Spirochaetes	203691|Spirochaetes	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
CMS1_k127_4561135_9	158190.SpiGrapes_0985	3.974e-85	286.0	COG0122@1|root,COG0122@2|Bacteria,2JAZG@203691|Spirochaetes	203691|Spirochaetes	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
CMS1_k127_4561135_11	158190.SpiGrapes_0986	1.226e-55	194.0	COG1403@1|root,COG1403@2|Bacteria,2J9QG@203691|Spirochaetes	203691|Spirochaetes	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4563345_9	158190.SpiGrapes_1977	9.321e-190	595.0	COG1904@1|root,COG1904@2|Bacteria,2J5RQ@203691|Spirochaetes	203691|Spirochaetes	G	Glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
CMS1_k127_4563345_14	158190.SpiGrapes_1976	4.079e-147	468.0	COG1414@1|root,COG1414@2|Bacteria,2J6B4@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, IclR family	-	-	-	ko:K19333	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
CMS1_k127_4563345_12	158190.SpiGrapes_1975	4.71e-171	542.0	COG0673@1|root,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_4563345_20	158190.SpiGrapes_1974	7.341e-59	205.0	COG1917@1|root,COG1917@2|Bacteria,2J8RQ@203691|Spirochaetes	203691|Spirochaetes	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS1_k127_4563345_3	158190.SpiGrapes_1972	4.505e-216	677.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS1_k127_4563345_19	158190.SpiGrapes_1971	6.568e-79	268.0	COG4902@1|root,COG4902@2|Bacteria,2JAMC@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
CMS1_k127_4563345_6	158190.SpiGrapes_1969	1.052e-208	651.0	COG0524@1|root,COG0524@2|Bacteria,2J5YN@203691|Spirochaetes	203691|Spirochaetes	G	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
CMS1_k127_4563345_10	158190.SpiGrapes_1968	2.592e-185	584.0	COG0800@1|root,COG0800@2|Bacteria,2J6B8@203691|Spirochaetes	203691|Spirochaetes	G	PFAM KDPG and KHG aldolase	eda	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
CMS1_k127_4563345_17	158190.SpiGrapes_1967	1.774e-98	330.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
CMS1_k127_4563345_5	158190.SpiGrapes_1966	2.174e-212	663.0	COG1840@1|root,COG1840@2|Bacteria,2J73E@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
CMS1_k127_4563345_0	158190.SpiGrapes_1965	0.0	1319.0	COG1178@1|root,COG1178@2|Bacteria,2J625@203691|Spirochaetes	203691|Spirochaetes	P	transport system permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
CMS1_k127_4563345_4	158190.SpiGrapes_1964	1.285e-214	669.0	COG3842@1|root,COG3842@2|Bacteria,2J6E4@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
CMS1_k127_4563345_7	158190.SpiGrapes_1963	3.913e-196	618.0	COG5438@1|root,COG5438@2|Bacteria,2J5HX@203691|Spirochaetes	203691|Spirochaetes	S	YibE F family protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
CMS1_k127_4563345_1	158190.SpiGrapes_1962	1.174e-264	822.0	COG1785@1|root,COG1785@2|Bacteria,2J67K@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the alkaline phosphatase family	phoB	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
CMS1_k127_4563345_8	158190.SpiGrapes_1959	4.411e-190	603.0	COG5434@1|root,COG5434@2|Bacteria,2J6G0@203691|Spirochaetes	203691|Spirochaetes	M	PFAM glycoside hydrolase family 28	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
CMS1_k127_4563345_16	158190.SpiGrapes_1958	4.051e-121	394.0	COG1082@1|root,COG1082@2|Bacteria,2J80X@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Xylose isomerase, TIM barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS1_k127_4563345_2	158190.SpiGrapes_1957	5.343e-233	723.0	COG1435@1|root,COG1435@2|Bacteria,2J6SK@203691|Spirochaetes	203691|Spirochaetes	F	thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
CMS1_k127_4563345_18	428125.CLOLEP_01471	9.049e-82	277.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,3WIFE@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
CMS1_k127_4563345_11	158190.SpiGrapes_1955	6.264e-174	549.0	COG1051@1|root,COG1051@2|Bacteria,2J968@203691|Spirochaetes	203691|Spirochaetes	F	pfam nudix	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
CMS1_k127_4563345_15	158190.SpiGrapes_1954	9.517e-127	411.0	COG0667@1|root,COG0667@2|Bacteria,2JBH9@203691|Spirochaetes	203691|Spirochaetes	C	reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS1_k127_4565332_2	877418.ATWV01000005_gene2479	2.862e-19	98.0	COG3339@1|root,COG3339@2|Bacteria,2J8VF@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
CMS1_k127_4565332_1	158190.SpiGrapes_0007	5.549e-146	471.0	COG4924@1|root,COG4924@2|Bacteria,2J9GM@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized protein conserved in bacteria N-term (DUF3322)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2220,DUF3322
CMS1_k127_4565332_0	158190.SpiGrapes_0008	0.0	1461.0	COG4913@1|root,COG4913@2|Bacteria,2J7KA@203691|Spirochaetes	203691|Spirochaetes	S	P-loop containing region of AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
CMS1_k127_4569423_13	158190.SpiGrapes_3273	1.967e-49	178.0	COG2017@1|root,COG2017@2|Bacteria,2J7JE@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Aldose 1-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim
CMS1_k127_4569423_4	158190.SpiGrapes_3272	4.271e-226	715.0	COG0373@1|root,COG1878@1|root,COG0373@2|Bacteria,COG1878@2|Bacteria,2J91W@203691|Spirochaetes	203691|Spirochaetes	H	Putative cyclase	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase,GlutR_N,Shikimate_DH
CMS1_k127_4569423_8	158190.SpiGrapes_3271	9.608e-109	357.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
CMS1_k127_4569423_6	158190.SpiGrapes_3269	2.958e-171	541.0	COG0031@1|root,COG0031@2|Bacteria,2J5EE@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS1_k127_4569423_12	158190.SpiGrapes_3268	9.142e-57	200.0	COG1959@1|root,COG1959@2|Bacteria,2J88R@203691|Spirochaetes	203691|Spirochaetes	K	TIGRFAM Rrf2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS1_k127_4569423_11	158190.SpiGrapes_3267	1.639e-58	205.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	cymR_2	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS1_k127_4569423_1	158190.SpiGrapes_3266	0.0	1058.0	COG0737@1|root,COG0737@2|Bacteria,2J5ZK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
CMS1_k127_4569423_9	158190.SpiGrapes_3264	1.127e-89	297.0	COG0693@1|root,COG0693@2|Bacteria,2J8IJ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM DJ-1 family protein	thiJ	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
CMS1_k127_4569423_5	158190.SpiGrapes_3263	2.594e-213	665.0	COG0722@1|root,COG0722@2|Bacteria,2J6I9@203691|Spirochaetes	203691|Spirochaetes	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
CMS1_k127_4569423_2	158190.SpiGrapes_3262	0.0	1032.0	COG1022@1|root,COG1022@2|Bacteria,2J6MK@203691|Spirochaetes	203691|Spirochaetes	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
CMS1_k127_4569423_7	158190.SpiGrapes_3261	2.719e-121	393.0	COG1235@1|root,COG1235@2|Bacteria,2JAK8@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS1_k127_4569423_14	158190.SpiGrapes_3260	2.038e-45	166.0	COG1393@1|root,COG1393@2|Bacteria	2|Bacteria	P	arsenate reductase (glutaredoxin) activity	arsC1	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC,Glutaredoxin
CMS1_k127_4569423_0	158190.SpiGrapes_3259	0.0	1065.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
CMS1_k127_4569423_3	158190.SpiGrapes_3257	5.873e-293	900.0	COG0017@1|root,COG0017@2|Bacteria,2J5AH@203691|Spirochaetes	203691|Spirochaetes	J	Asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS1_k127_4569423_10	158190.SpiGrapes_3256	2.407e-62	219.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	AlbA_2,GerE,HATPase_c_4,HTH_24
CMS1_k127_4583406_1	1125701.HMPREF1221_01915	2.867e-206	647.0	COG4948@1|root,COG4948@2|Bacteria,2J9JE@203691|Spirochaetes	2|Bacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS1_k127_4583406_2	742735.HMPREF9467_01407	8.011e-121	393.0	COG0491@1|root,COG0491@2|Bacteria,1UZ50@1239|Firmicutes,24A1I@186801|Clostridia	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS1_k127_4583406_0	742735.HMPREF9467_01406	2.126e-242	756.0	COG3333@1|root,COG3333@2|Bacteria,1VUA4@1239|Firmicutes,24Z03@186801|Clostridia	186801|Clostridia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
CMS1_k127_4583406_4	689781.AUJX01000018_gene2437	1.159e-39	153.0	29447@1|root,2ZRIU@2|Bacteria,1W59Y@1239|Firmicutes,257GN@186801|Clostridia,2PTEM@265975|Oribacterium	186801|Clostridia	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
CMS1_k127_4583406_3	742735.HMPREF9467_01403	1.299e-52	190.0	COG3181@1|root,COG3181@2|Bacteria,1UEBF@1239|Firmicutes,25J70@186801|Clostridia,22316@1506553|Lachnoclostridium	186801|Clostridia	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
CMS1_k127_459192_1	485917.Phep_2431	3.149e-34	143.0	COG2207@1|root,COG2207@2|Bacteria,4NMFW@976|Bacteroidetes,1IUWY@117747|Sphingobacteriia	976|Bacteroidetes	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
CMS1_k127_459192_0	158190.SpiGrapes_2373	4.796e-114	374.0	COG1082@1|root,COG1082@2|Bacteria,2J8EP@203691|Spirochaetes	203691|Spirochaetes	G	TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
CMS1_k127_4594728_9	760011.Spico_1499	2.331e-108	353.0	COG3177@1|root,COG3177@2|Bacteria,2J6YE@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Filamentation induced by cAMP	-	-	-	-	-	-	-	-	-	-	-	-	Fic
CMS1_k127_4594728_6	158190.SpiGrapes_2766	2.604e-133	428.0	COG0528@1|root,COG0528@2|Bacteria,2J5H9@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS1_k127_4594728_5	158190.SpiGrapes_2764	9.216e-166	527.0	COG1313@1|root,COG1313@2|Bacteria,2J68B@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_4594728_3	158190.SpiGrapes_2763	1.274e-230	720.0	COG3621@1|root,COG3621@2|Bacteria,2JAHA@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
CMS1_k127_4594728_14	521010.BbiDN127_0096	1.112e-27	116.0	2EET3@1|root,338KM@2|Bacteria,2J87J@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4594728_11	158190.SpiGrapes_2761	4.594e-87	292.0	COG0775@1|root,COG0775@2|Bacteria	2|Bacteria	F	adenosylhomocysteine nucleosidase activity	mtnN	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008652,GO:0008782,GO:0008930,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009116,GO:0009119,GO:0009987,GO:0016053,GO:0016787,GO:0016798,GO:0016799,GO:0017144,GO:0019284,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0042802,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046394,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657	3.2.2.16,3.2.2.26,3.2.2.30,3.2.2.9	ko:K01243,ko:K01244,ko:K11783,ko:K18284	ko00130,ko00270,ko01100,ko01110,ko01230,map00130,map00270,map01100,map01110,map01230	M00034,M00609	R00194,R01401,R08587,R10668	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3384,iSBO_1134.SBO_0148	PNP_UDP_1
CMS1_k127_4594728_7	158190.SpiGrapes_2760	2.957e-121	395.0	COG2240@1|root,COG2240@2|Bacteria,2J883@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the pyridoxine kinase family	pdxK	-	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100	-	R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin
CMS1_k127_4594728_2	158190.SpiGrapes_2759	1.667e-313	972.0	COG1109@1|root,COG1109@2|Bacteria,2J6Q6@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	femD	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_III
CMS1_k127_4594728_13	158190.SpiGrapes_2758	1.029e-63	221.0	COG3727@1|root,COG3727@2|Bacteria,2J8EE@203691|Spirochaetes	203691|Spirochaetes	L	May nick specific sequences that contain T G mispairs resulting from m5C-deamination	-	-	-	ko:K07458	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Vsr
CMS1_k127_4594728_12	158190.SpiGrapes_2757	1.271e-75	258.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Thioredoxin
CMS1_k127_4594728_1	158190.SpiGrapes_2755	0.0	1034.0	COG1874@1|root,COG1874@2|Bacteria,2J8P9@203691|Spirochaetes	203691|Spirochaetes	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
CMS1_k127_4594728_0	158190.SpiGrapes_2754	0.0	1052.0	COG1653@1|root,COG1653@2|Bacteria,2J5AY@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
CMS1_k127_4594728_10	1122927.KB895436_gene4334	5.585e-104	348.0	COG0395@1|root,COG0395@2|Bacteria,1TQ9F@1239|Firmicutes,4HBG3@91061|Bacilli,26R1X@186822|Paenibacillaceae	91061|Bacilli	G	binding-protein-dependent transport systems inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_4594728_4	158190.SpiGrapes_2752	1.746e-172	544.0	COG4209@1|root,COG4209@2|Bacteria,2J7E1@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
CMS1_k127_4594728_8	158190.SpiGrapes_2751	4.519e-109	355.0	COG1609@1|root,COG1609@2|Bacteria,2J6P1@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_4595155_0	445972.ANACOL_00510	6.744e-168	535.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,24AE7@186801|Clostridia,3WMXH@541000|Ruminococcaceae	186801|Clostridia	M	mandelate racemase muconate lactonizing	-	-	4.2.1.5,4.2.1.6	ko:K01683,ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS1_k127_4595155_1	457421.CBFG_02152	6.764e-131	432.0	COG0531@1|root,COG0531@2|Bacteria,1V0MG@1239|Firmicutes,25P28@186801|Clostridia,26ABY@186813|unclassified Clostridiales	186801|Clostridia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
CMS1_k127_4595155_2	457421.CBFG_04747	1.168e-128	422.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,24AE7@186801|Clostridia	186801|Clostridia	M	Mandelate racemase muconate lactonizing enzyme	-	-	4.2.1.5,4.2.1.6	ko:K01683,ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS1_k127_4606716_18	158190.SpiGrapes_2937	2.531e-50	181.0	COG0546@1|root,COG0546@2|Bacteria,2J7WT@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_4606716_16	158190.SpiGrapes_2938	6.074e-73	249.0	COG0655@1|root,COG0655@2|Bacteria,2J9EZ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS1_k127_4606716_17	158190.SpiGrapes_2939	6.416e-58	204.0	COG0251@1|root,COG0251@2|Bacteria,2J8EX@203691|Spirochaetes	203691|Spirochaetes	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CMS1_k127_4606716_8	158190.SpiGrapes_2940	6.931e-206	644.0	COG0404@1|root,COG0404@2|Bacteria,2J6B1@203691|Spirochaetes	203691|Spirochaetes	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
CMS1_k127_4606716_4	158190.SpiGrapes_2941	4.626e-234	728.0	COG4908@1|root,COG4908@2|Bacteria,2JAB4@203691|Spirochaetes	203691|Spirochaetes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4606716_14	573413.Spirs_3593	2.664e-119	389.0	COG0842@1|root,COG0842@2|Bacteria,2J9DM@203691|Spirochaetes	203691|Spirochaetes	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
CMS1_k127_4606716_11	1121342.AUCO01000005_gene324	1.435e-134	437.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
CMS1_k127_4606716_19	768706.Desor_0372	4.906e-45	171.0	COG1846@1|root,COG1846@2|Bacteria,1VBKX@1239|Firmicutes,24I4R@186801|Clostridia,26710@186807|Peptococcaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS1_k127_4606716_20	1410638.JHXJ01000001_gene1631	7.624e-41	158.0	COG3554@1|root,COG3554@2|Bacteria,1V3D8@1239|Firmicutes,24HRC@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4606716_15	158190.SpiGrapes_2943	1.192e-84	282.0	COG2606@1|root,COG2606@2|Bacteria,2J83H@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
CMS1_k127_4606716_9	158190.SpiGrapes_2944	2.642e-184	586.0	COG1079@1|root,COG1079@2|Bacteria,2JA5I@203691|Spirochaetes	203691|Spirochaetes	P	transport system permease	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_4606716_7	158190.SpiGrapes_2945	3.762e-215	670.0	COG4603@1|root,COG4603@2|Bacteria,2J9QY@203691|Spirochaetes	203691|Spirochaetes	P	transport system permease	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_4606716_2	158190.SpiGrapes_2946	1.25e-304	938.0	COG3845@1|root,COG3845@2|Bacteria,2J9Q1@203691|Spirochaetes	203691|Spirochaetes	S	pfam abc	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_4606716_5	158190.SpiGrapes_2947	8.585e-223	692.0	COG1744@1|root,COG1744@2|Bacteria,2J7UH@203691|Spirochaetes	203691|Spirochaetes	S	Membrane protein, bmp family	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
CMS1_k127_4606716_3	158190.SpiGrapes_2948	1.475e-239	750.0	COG1596@1|root,COG1596@2|Bacteria,2J6A1@203691|Spirochaetes	203691|Spirochaetes	M	export protein	-	-	-	-	-	-	-	-	-	-	-	-	SLBB
CMS1_k127_4606716_0	158190.SpiGrapes_2949	0.0	1154.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
CMS1_k127_4606716_1	158190.SpiGrapes_2950	2.962e-320	983.0	COG0540@1|root,COG1781@1|root,COG0540@2|Bacteria,COG1781@2|Bacteria,2J5J0@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Aspartate ornithine carbamoyltransferase, carbamoyl-P binding	pyrB	-	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI,PyrI_C
CMS1_k127_4606716_13	158190.SpiGrapes_2951	1.847e-124	404.0	COG0461@1|root,COG0461@2|Bacteria,2J744@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10,4.1.1.23	ko:K00762,ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965,R01870	RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
CMS1_k127_4606716_10	158190.SpiGrapes_2952	8.47e-164	518.0	COG0284@1|root,COG0284@2|Bacteria,2J6HE@203691|Spirochaetes	203691|Spirochaetes	F	Orotidine 5''-phosphate decarboxylase	pyrF	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
CMS1_k127_4606716_6	158190.SpiGrapes_2953	4.973e-222	693.0	COG0167@1|root,COG0543@1|root,COG0167@2|Bacteria,COG0543@2|Bacteria,2J610@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,DHO_dh,FAD_binding_6
CMS1_k127_4635556_1	1255043.TVNIR_2308	1.257e-97	325.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,1X09K@135613|Chromatiales	135613|Chromatiales	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigB
CMS1_k127_4635556_0	158190.SpiGrapes_2335	2.416e-137	447.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	2.7.7.65	ko:K21022	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF,Reg_prop,Y_Y_Y
CMS1_k127_4641489_8	158190.SpiGrapes_3110	2.149e-56	199.0	COG0399@1|root,COG0399@2|Bacteria,2J650@203691|Spirochaetes	203691|Spirochaetes	M	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4641489_1	158190.SpiGrapes_3111	3.518e-201	629.0	COG1363@1|root,COG1363@2|Bacteria,2J70N@203691|Spirochaetes	203691|Spirochaetes	G	peptidase M42	frvX	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
CMS1_k127_4641489_6	158190.SpiGrapes_3112	9.144e-142	452.0	COG1402@1|root,COG1402@2|Bacteria,2J59T@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS1_k127_4641489_0	158190.SpiGrapes_3113	2.64e-321	985.0	COG0747@1|root,COG0747@2|Bacteria,2J6ZT@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS1_k127_4641489_4	158190.SpiGrapes_3114	4.676e-178	560.0	COG4608@1|root,COG4608@2|Bacteria,2J5YH@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_4641489_3	158190.SpiGrapes_3115	9.97e-182	571.0	COG0444@1|root,COG0444@2|Bacteria,2J5F3@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS1_k127_4641489_5	158190.SpiGrapes_3116	1.454e-161	512.0	COG1173@1|root,COG1173@2|Bacteria,2J78T@203691|Spirochaetes	203691|Spirochaetes	P	transport system	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS1_k127_4641489_2	158190.SpiGrapes_3117	3.847e-184	582.0	COG0601@1|root,COG0601@2|Bacteria,2J635@203691|Spirochaetes	203691|Spirochaetes	P	Permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_4641489_7	158190.SpiGrapes_3118	1.222e-134	432.0	COG2362@1|root,COG2362@2|Bacteria,2JB4K@203691|Spirochaetes	203691|Spirochaetes	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
CMS1_k127_464766_1	931626.Awo_c05260	4.233e-132	430.0	COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,25V1R@186806|Eubacteriaceae	186801|Clostridia	T	Psort location Cytoplasmic, score	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,PAS_3,Response_reg
CMS1_k127_464766_0	765911.Thivi_1206	0.0	1163.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1X2T5@135613|Chromatiales	135613|Chromatiales	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
CMS1_k127_4669268_7	1499967.BAYZ01000076_gene787	1.811e-82	278.0	COG4608@1|root,COG4608@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_4669268_3	158190.SpiGrapes_1519	7.076e-197	618.0	COG0444@1|root,COG0444@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_4669268_5	158190.SpiGrapes_1520	5.849e-170	539.0	COG1173@1|root,COG1173@2|Bacteria,2J7MD@203691|Spirochaetes	203691|Spirochaetes	EP	transport system permease	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
CMS1_k127_4669268_4	158190.SpiGrapes_1521	4.21e-191	599.0	COG0601@1|root,COG0601@2|Bacteria,2J6BK@203691|Spirochaetes	203691|Spirochaetes	EP	Permease protein	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_4669268_0	158190.SpiGrapes_1522	0.0	1045.0	COG0747@1|root,COG0747@2|Bacteria,2J9WF@203691|Spirochaetes	203691|Spirochaetes	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS1_k127_4669268_1	158190.SpiGrapes_1760	1.551e-283	873.0	COG1115@1|root,COG1115@2|Bacteria,2J68D@203691|Spirochaetes	203691|Spirochaetes	U	amino acid carrier protein	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
CMS1_k127_4669268_2	158190.SpiGrapes_1759	5.816e-229	715.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_4669268_6	158190.SpiGrapes_1758	1.653e-139	444.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_4669268_8	869209.Tresu_0924	0.0005102	43.0	COG3093@1|root,COG3093@2|Bacteria,2J9C8@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,Peptidase_M78
CMS1_k127_4710400_1	158190.SpiGrapes_0389	2.301e-104	346.0	COG1533@1|root,COG1533@2|Bacteria,2J7T9@203691|Spirochaetes	203691|Spirochaetes	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
CMS1_k127_4710400_2	536232.CLM_2280	1.056e-13	72.0	COG2002@1|root,COG2002@2|Bacteria,1VDAQ@1239|Firmicutes,25BQF@186801|Clostridia	186801|Clostridia	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
CMS1_k127_4710400_0	158190.SpiGrapes_0386	1.364e-247	771.0	COG1233@1|root,COG1233@2|Bacteria,2J694@203691|Spirochaetes	203691|Spirochaetes	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
CMS1_k127_4721961_0	158190.SpiGrapes_2987	1.496e-228	714.0	COG0534@1|root,COG0534@2|Bacteria,2J6AV@203691|Spirochaetes	203691|Spirochaetes	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_4721961_4	158190.SpiGrapes_2988	1.774e-150	478.0	COG1101@1|root,COG1101@2|Bacteria,2J5X9@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
CMS1_k127_4721961_3	158190.SpiGrapes_2989	2.842e-176	556.0	COG4120@1|root,COG4120@2|Bacteria,2J6KD@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
CMS1_k127_4721961_1	158190.SpiGrapes_2990	2.64e-187	591.0	COG2984@1|root,COG2984@2|Bacteria,2J62D@203691|Spirochaetes	203691|Spirochaetes	S	PFAM ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
CMS1_k127_4721961_2	158190.SpiGrapes_2991	7.577e-179	565.0	COG0673@1|root,COG0673@2|Bacteria,2J71R@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_4736419_5	1200567.JNKD01000029_gene1256	5.724e-05	46.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
CMS1_k127_4736419_2	158190.SpiGrapes_2629	6.737e-235	733.0	COG0569@1|root,COG0569@2|Bacteria,2J59W@203691|Spirochaetes	203691|Spirochaetes	C	Trk system potassium uptake protein TrkA	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS1_k127_4736419_1	158190.SpiGrapes_2628	1.166e-259	808.0	COG0168@1|root,COG0168@2|Bacteria,2J5J7@203691|Spirochaetes	203691|Spirochaetes	P	potassium uptake protein TrkH	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS1_k127_4736419_0	158190.SpiGrapes_2627	1.75e-260	807.0	COG2610@1|root,COG2610@2|Bacteria,2J5W9@203691|Spirochaetes	203691|Spirochaetes	EG	Gluconate	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
CMS1_k127_4736419_3	158190.SpiGrapes_2626	3.243e-200	628.0	COG1929@1|root,COG1929@2|Bacteria,2J5ZM@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
CMS1_k127_4736419_4	158190.SpiGrapes_2625	1.051e-87	297.0	COG4912@1|root,COG4912@2|Bacteria,2J6HK@203691|Spirochaetes	203691|Spirochaetes	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
CMS1_k127_475038_6	743719.PaelaDRAFT_3382	8.835e-80	276.0	2C4GI@1|root,2Z7IK@2|Bacteria,1TR77@1239|Firmicutes,4HC64@91061|Bacilli,26RGK@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1861)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1861
CMS1_k127_475038_3	1274374.CBLK010000059_gene476	1.142e-102	350.0	COG2152@1|root,COG2152@2|Bacteria,1TQE7@1239|Firmicutes,4HAUT@91061|Bacilli,275NJ@186822|Paenibacillaceae	91061|Bacilli	G	glycosidase	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
CMS1_k127_475038_4	1480694.DC28_15105	1.695e-98	328.0	COG0395@1|root,COG0395@2|Bacteria,2J64K@203691|Spirochaetes	2|Bacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_475038_5	1480694.DC28_15110	2.371e-89	303.0	COG1175@1|root,COG1175@2|Bacteria,2J5N6@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17245	ko02010,map02010	M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.40	-	-	-
CMS1_k127_475038_2	1480694.DC28_15115	3.867e-159	514.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
CMS1_k127_475038_7	1480694.DC28_15120	1.767e-71	254.0	COG1609@1|root,COG1609@2|Bacteria,2J87T@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
CMS1_k127_475038_1	158190.SpiGrapes_2378	1.541e-185	582.0	COG2358@1|root,COG2358@2|Bacteria,2J705@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
CMS1_k127_475038_0	158190.SpiGrapes_2379	0.0	1127.0	COG4666@1|root,COG4666@2|Bacteria,2J57Z@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
CMS1_k127_4756853_5	158190.SpiGrapes_3227	3.103e-18	84.0	COG0773@1|root,COG0773@2|Bacteria,2J5DC@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS1_k127_4756853_2	158190.SpiGrapes_3228	2.354e-160	508.0	COG1561@1|root,COG1561@2|Bacteria,2J76C@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TIGR00255 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
CMS1_k127_4756853_4	158190.SpiGrapes_3229	9.547e-85	283.0	COG1102@1|root,COG1102@2|Bacteria,2J5P9@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
CMS1_k127_4756853_7	596324.TREVI0001_2243	1.643e-05	49.0	COG1758@1|root,2ZVPX@2|Bacteria,2J8SX@203691|Spirochaetes	203691|Spirochaetes	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
CMS1_k127_4756853_3	158189.SpiBuddy_1780	1.417e-133	433.0	COG0324@1|root,COG0324@2|Bacteria,2J6T2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
CMS1_k127_4756853_1	158190.SpiGrapes_3235	3.036e-234	734.0	2FJ33@1|root,34ATE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4756853_0	158190.SpiGrapes_3237	1.909e-245	762.0	COG1293@1|root,COG1293@2|Bacteria,2J61Z@203691|Spirochaetes	203691|Spirochaetes	K	Fibrinogen-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
CMS1_k127_4784042_1	158189.SpiBuddy_3032	8.928e-61	214.0	COG1739@1|root,COG1739@2|Bacteria,2J7AS@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0029, Impact, N-terminal	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF1949,UPF0029
CMS1_k127_4784042_0	158190.SpiGrapes_1952	3.224e-224	702.0	COG2234@1|root,COG2234@2|Bacteria,2JAZA@203691|Spirochaetes	203691|Spirochaetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS1_k127_478849_4	642492.Clole_0546	5.482e-15	74.0	COG0624@1|root,COG0624@2|Bacteria,1TQ0P@1239|Firmicutes,24BF2@186801|Clostridia	186801|Clostridia	E	Amidase, hydantoinase carbamoylase family	amaB	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_478849_2	272563.CD630_11260	1.232e-19	91.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,2496K@186801|Clostridia,25QEU@186804|Peptostreptococcaceae	186801|Clostridia	K	Bacterial transcription activator, effector binding domain	ydeE	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like,HTH_18
CMS1_k127_478849_5	1294142.CINTURNW_1820	7.924e-06	51.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,2496K@186801|Clostridia,36EDW@31979|Clostridiaceae	186801|Clostridia	K	transcription activator, effector binding	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like,HTH_18
CMS1_k127_478849_0	1238450.VIBNISOn1_450050	3.656e-59	211.0	COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,1S3XS@1236|Gammaproteobacteria,1XXQG@135623|Vibrionales	135623|Vibrionales	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS1_k127_478849_1	158190.SpiGrapes_2371	3.211e-58	210.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS1_k127_478849_3	742735.HMPREF9467_00149	6.719e-16	79.0	COG0407@1|root,COG0407@2|Bacteria,1TNYE@1239|Firmicutes,24DSS@186801|Clostridia,21ZT2@1506553|Lachnoclostridium	186801|Clostridia	H	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
CMS1_k127_4792012_5	158190.SpiGrapes_1862	7.998e-58	201.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,2J6KN@203691|Spirochaetes	203691|Spirochaetes	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
CMS1_k127_4792012_2	1105031.HMPREF1141_2016	4.515e-147	473.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,36E13@31979|Clostridiaceae	186801|Clostridia	CH	D-isomer specific 2-hydroxyacid dehydrogenase	hprA	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS1_k127_4792012_3	158190.SpiGrapes_1863	2.193e-135	432.0	COG0564@1|root,COG0564@2|Bacteria,2J7QE@203691|Spirochaetes	203691|Spirochaetes	J	Pseudouridine synthase	rluC	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
CMS1_k127_4792012_0	158190.SpiGrapes_1864	0.0	1204.0	COG0188@1|root,COG0188@2|Bacteria,2J5Y9@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the type II topoisomerase GyrA ParC subunit family	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_topoisoIV
CMS1_k127_4792012_1	158190.SpiGrapes_1865	0.0	1160.0	COG0187@1|root,COG0187@2|Bacteria,2J6PT@203691|Spirochaetes	203691|Spirochaetes	L	DNA topoisomerase	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS1_k127_4792012_4	158190.SpiGrapes_1866	1.283e-71	247.0	COG3714@1|root,COG3714@2|Bacteria	2|Bacteria	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
CMS1_k127_4792012_6	158190.SpiGrapes_1867	8.849e-11	63.0	COG0598@1|root,COG0598@2|Bacteria,2J6SS@203691|Spirochaetes	203691|Spirochaetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS1_k127_4797384_0	1280692.AUJL01000014_gene3239	1.252e-47	177.0	COG2256@1|root,COG2256@2|Bacteria,1TXDS@1239|Firmicutes,24EUP@186801|Clostridia,36GQ7@31979|Clostridiaceae	186801|Clostridia	L	MgsA AAA+ ATPase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MgsA_C
CMS1_k127_4797384_1	1137269.AZWL01000002_gene6266	4.848e-06	55.0	COG1653@1|root,COG1653@2|Bacteria,2GNJW@201174|Actinobacteria	201174|Actinobacteria	G	solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_4845726_1	742733.HMPREF9469_04349	2.043e-140	460.0	COG1653@1|root,COG1653@2|Bacteria,1V0P9@1239|Firmicutes,25BEX@186801|Clostridia,21XKT@1506553|Lachnoclostridium	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10192	ko02010,map02010	M00202	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.11	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_4845726_0	742733.HMPREF9469_04350	5.629e-283	889.0	COG3533@1|root,COG3533@2|Bacteria,1TRXQ@1239|Firmicutes,24BS8@186801|Clostridia,222HH@1506553|Lachnoclostridium	186801|Clostridia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127
CMS1_k127_4845726_2	1340434.AXVA01000008_gene3739	4.235e-55	203.0	COG2972@1|root,COG2972@2|Bacteria,1UWR1@1239|Firmicutes,4ICE7@91061|Bacilli,1ZFAM@1386|Bacillus	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
CMS1_k127_4854129_1	158190.SpiGrapes_2986	7.21e-212	659.0	COG4213@1|root,COG4213@2|Bacteria,2J5TP@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type xylose transport system, periplasmic component	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
CMS1_k127_4854129_0	158190.SpiGrapes_2985	3.363e-304	937.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10441,ko:K10542,ko:K10545,ko:K10548,ko:K17215	ko02010,map02010	M00212,M00214,M00215,M00216,M00221,M00593	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.4,3.A.1.2.5	-	-	ABC_tran
CMS1_k127_4854129_2	158190.SpiGrapes_2984	6.856e-20	91.0	COG4214@1|root,COG4214@2|Bacteria,2J5AE@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
CMS1_k127_4861523_0	158190.SpiGrapes_0027	3.835e-207	646.0	COG3333@1|root,COG3333@2|Bacteria,2J70X@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
CMS1_k127_4861523_9	158190.SpiGrapes_0028	1.859e-71	244.0	2EH1Q@1|root,33ATP@2|Bacteria,2J97J@203691|Spirochaetes	203691|Spirochaetes	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
CMS1_k127_4861523_1	158190.SpiGrapes_0029	2.382e-183	576.0	COG3181@1|root,COG3181@2|Bacteria,2J7TJ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
CMS1_k127_4861523_8	158190.SpiGrapes_0030	6.515e-92	306.0	COG0800@1|root,COG0800@2|Bacteria,2J6B8@203691|Spirochaetes	203691|Spirochaetes	G	PFAM KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
CMS1_k127_4861523_3	158190.SpiGrapes_0031	1.126e-151	484.0	COG0524@1|root,COG0524@2|Bacteria,2J8VA@203691|Spirochaetes	203691|Spirochaetes	H	Carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
CMS1_k127_4861523_4	158190.SpiGrapes_0032	6.233e-129	416.0	COG1414@1|root,COG1414@2|Bacteria,2J6B4@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, IclR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
CMS1_k127_4861523_12	1353528.DT23_02670	3.206e-40	151.0	COG1917@1|root,COG1917@2|Bacteria,1RHSW@1224|Proteobacteria,2VAQW@28211|Alphaproteobacteria,2XPGY@285107|Thioclava	28211|Alphaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS1_k127_4861523_11	1121447.JONL01000005_gene1620	8.684e-52	205.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,430MS@68525|delta/epsilon subdivisions,2WVKJ@28221|Deltaproteobacteria,2MHDV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3,dCache_1
CMS1_k127_4861523_10	1230342.CTM_02224	6.052e-71	252.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,24D5Y@186801|Clostridia,36E83@31979|Clostridiaceae	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_4861523_7	1319815.HMPREF0202_00228	6.322e-97	324.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	amyC	-	-	ko:K02026,ko:K10119	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_4861523_6	1319815.HMPREF0202_00229	1.705e-108	360.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	amyD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K10118,ko:K15771	ko02010,map02010	M00196,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2,3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_4861523_5	340099.Teth39_0607	1.558e-125	414.0	COG1653@1|root,COG1653@2|Bacteria,1TR3D@1239|Firmicutes,25BE2@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
CMS1_k127_4861523_2	1120972.AUMH01000008_gene1994	2.819e-153	492.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,4HCGH@91061|Bacilli	91061|Bacilli	G	Catalyses the hydrolysis of terminal non-reducing alpha-D-galactose residues in alpha-D-galactosides	melA	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
CMS1_k127_491345_0	158190.SpiGrapes_1418	8.119e-264	819.0	COG3845@1|root,COG3845@2|Bacteria,2J5GB@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_491345_1	158190.SpiGrapes_1417	8.899e-197	619.0	COG4603@1|root,COG4603@2|Bacteria,2JAG2@203691|Spirochaetes	203691|Spirochaetes	P	transport system permease	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_491345_2	158190.SpiGrapes_1416	1.421e-27	112.0	COG1079@1|root,COG1079@2|Bacteria,2J6HU@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_494719_4	158189.SpiBuddy_0328	1.382e-97	324.0	COG5340@1|root,COG5340@2|Bacteria,2JAKA@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_494719_2	158189.SpiBuddy_0327	6.66e-132	426.0	COG2253@1|root,COG2253@2|Bacteria,2J5IH@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS1_k127_494719_0	1514668.JOOA01000002_gene1516	2.088e-186	594.0	COG1672@1|root,COG1672@2|Bacteria,1TR21@1239|Firmicutes,24ADD@186801|Clostridia,3WH55@541000|Ruminococcaceae	186801|Clostridia	S	ATPase domain predominantly from Archaea	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_2,DUF234
CMS1_k127_494719_5	744872.Spica_1367	5.814e-50	185.0	COG0036@1|root,COG0036@2|Bacteria,2J7B7@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
CMS1_k127_494719_1	1125725.HMPREF1325_2179	5.351e-169	545.0	COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_494719_3	1125725.HMPREF1325_2180	2.379e-115	376.0	COG1172@1|root,COG1172@2|Bacteria,2J6T9@203691|Spirochaetes	203691|Spirochaetes	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS1_k127_4955197_4	158190.SpiGrapes_0714	6.558e-102	334.0	COG0765@1|root,COG0765@2|Bacteria,2J8NA@203691|Spirochaetes	203691|Spirochaetes	P	acid ABC transporter	-	-	-	ko:K10040	ko02010,map02010	M00228	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
CMS1_k127_4955197_2	158190.SpiGrapes_0715	2.28e-113	368.0	COG0765@1|root,COG0765@2|Bacteria,2J7P6@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029,ko:K10040	ko02010,map02010	M00228,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
CMS1_k127_4955197_1	158190.SpiGrapes_0716	9.759e-146	466.0	COG0834@1|root,COG0834@2|Bacteria,2J7H4@203691|Spirochaetes	203691|Spirochaetes	ET	PFAM Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K10039	ko02010,map02010	M00228	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS1_k127_4955197_0	158190.SpiGrapes_0717	4.762e-147	467.0	COG1126@1|root,COG1126@2|Bacteria,2J5V5@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type polar amino acid transport system ATPase component	-	-	-	ko:K10041	ko02010,map02010	M00228	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
CMS1_k127_4955197_5	1449343.JQLQ01000002_gene910	1.481e-39	151.0	COG2128@1|root,COG2128@2|Bacteria,1VAK9@1239|Firmicutes,4HQMH@91061|Bacilli	91061|Bacilli	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS1_k127_4955197_3	158190.SpiGrapes_0722	2.777e-112	368.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS1_k127_4978313_5	158190.SpiGrapes_0364	4.309e-83	277.0	COG0781@1|root,COG0781@2|Bacteria,2J91Y@203691|Spirochaetes	203691|Spirochaetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
CMS1_k127_4978313_2	158190.SpiGrapes_0363	1.116e-176	559.0	COG0760@1|root,COG0760@2|Bacteria,2J6I2@203691|Spirochaetes	203691|Spirochaetes	M	peptidylprolyl isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
CMS1_k127_4978313_6	158190.SpiGrapes_0362	1.599e-67	231.0	COG0716@1|root,COG0716@2|Bacteria,2J892@203691|Spirochaetes	203691|Spirochaetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4978313_7	158190.SpiGrapes_0361	1.277e-48	176.0	COG1314@1|root,COG1314@2|Bacteria,2J7UR@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
CMS1_k127_4978313_3	158190.SpiGrapes_0360	4.327e-146	464.0	COG0149@1|root,COG0149@2|Bacteria,2J5FV@203691|Spirochaetes	203691|Spirochaetes	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
CMS1_k127_4978313_0	158190.SpiGrapes_0359	2.637e-229	713.0	COG0126@1|root,COG0126@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
CMS1_k127_4978313_1	158190.SpiGrapes_0358	1.184e-203	635.0	COG0057@1|root,COG0057@2|Bacteria,2J5AD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CMS1_k127_4978313_4	158190.SpiGrapes_0357	8.997e-140	446.0	COG1253@1|root,COG1253@2|Bacteria,2J61P@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1253 Hemolysins and related protein containing CBS domains	tlyC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC
CMS1_k127_5033491_1	158190.SpiGrapes_0640	7.17e-242	752.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
CMS1_k127_5033491_0	158190.SpiGrapes_0641	0.0	1084.0	COG0488@1|root,COG0488@2|Bacteria,2J5AN@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS1_k127_5033491_2	760011.Spico_0689	1.574e-30	126.0	COG0424@1|root,COG0424@2|Bacteria,2J7EA@203691|Spirochaetes	203691|Spirochaetes	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CMS1_k127_5050748_2	158190.SpiGrapes_0601	7.879e-113	369.0	COG0813@1|root,COG0813@2|Bacteria,2J5DI@203691|Spirochaetes	203691|Spirochaetes	F	purine-nucleoside phosphorylase	deoD	-	2.4.2.1	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
CMS1_k127_5050748_1	158190.SpiGrapes_0600	1.546e-132	425.0	COG3330@1|root,COG3330@2|Bacteria,2J8MZ@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4912)	-	-	-	ko:K09942	-	-	-	-	ko00000	-	-	-	DUF4912
CMS1_k127_5050748_0	158190.SpiGrapes_0599	0.0	1020.0	COG1543@1|root,COG1543@2|Bacteria,2J628@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
CMS1_k127_5050748_3	158190.SpiGrapes_0598	1.14e-06	54.0	COG2001@1|root,COG2001@2|Bacteria,2J7XS@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CMS1_k127_5121291_3	931626.Awo_c33310	6.404e-31	135.0	COG0249@1|root,COG0249@2|Bacteria,1TPJP@1239|Firmicutes,247IW@186801|Clostridia,25XEI@186806|Eubacteriaceae	186801|Clostridia	L	ATPase domain of DNA mismatch repair MUTS family	mutS2	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
CMS1_k127_5121291_0	1123274.KB899425_gene2737	5.948e-87	294.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,PAS_3
CMS1_k127_5121291_1	158190.SpiGrapes_2880	9.645e-58	203.0	COG0629@1|root,COG0629@2|Bacteria,2J86A@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS1_k127_5121291_2	573413.Spirs_4183	2.444e-51	185.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yiaC	-	2.3.1.1	ko:K03826,ko:K22476	ko00220,ko01210,ko01230,map00220,map01210,map01230	-	R00259	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_10,Acetyltransf_7
CMS1_k127_5148110_3	411471.SUBVAR_06759	2.829e-108	368.0	COG2972@1|root,COG2972@2|Bacteria,1TSM9@1239|Firmicutes,24F2N@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
CMS1_k127_5148110_4	1232453.BAIF02000089_gene2930	3.412e-71	247.0	COG2186@1|root,COG2186@2|Bacteria,1VD07@1239|Firmicutes,24PBV@186801|Clostridia	186801|Clostridia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_5148110_0	1232453.BAIF02000089_gene2931	8.633e-163	517.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,267TH@186813|unclassified Clostridiales	2|Bacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS07505,iIT341.HP0330	IlvC,IlvN
CMS1_k127_5148110_2	1125725.HMPREF1325_1999	1.859e-134	441.0	COG2610@1|root,COG2610@2|Bacteria,2J6R0@203691|Spirochaetes	2|Bacteria	EG	GntP family permease	gntP	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
CMS1_k127_5148110_1	158190.SpiGrapes_1700	9.137e-140	451.0	COG2865@1|root,COG2865@2|Bacteria,2J8E8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5154592_15	367737.Abu_1483	4.142e-20	93.0	COG1396@1|root,COG1396@2|Bacteria,1NGG5@1224|Proteobacteria,42XQ8@68525|delta/epsilon subdivisions,2YSGC@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_5154592_11	158189.SpiBuddy_0431	5.093e-95	318.0	COG2746@1|root,COG2746@2|Bacteria	2|Bacteria	V	aminoglycoside 3-N-acetyltransferase activity	aacC	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
CMS1_k127_5154592_3	158190.SpiGrapes_1531	1.426e-190	598.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
CMS1_k127_5154592_0	158190.SpiGrapes_1532	6.847e-256	794.0	COG0644@1|root,COG0644@2|Bacteria,2J7AH@203691|Spirochaetes	203691|Spirochaetes	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
CMS1_k127_5154592_12	1122214.AQWH01000001_gene586	8.459e-78	269.0	COG0395@1|root,COG0395@2|Bacteria,1PHF1@1224|Proteobacteria,2V87D@28211|Alphaproteobacteria,2PM06@255475|Aurantimonadaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_5154592_4	158190.SpiGrapes_1534	1.063e-180	567.0	COG1175@1|root,COG1175@2|Bacteria,2J9MW@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_5154592_1	158190.SpiGrapes_1535	8.221e-254	786.0	COG1653@1|root,COG1653@2|Bacteria,2JA3H@203691|Spirochaetes	203691|Spirochaetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
CMS1_k127_5154592_16	158190.SpiGrapes_1536	1.168e-14	76.0	COG2199@1|root,COG3706@2|Bacteria,2J7K5@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_5154592_10	158190.SpiGrapes_1539	6.097e-106	354.0	COG3527@1|root,COG3527@2|Bacteria,2J8ID@203691|Spirochaetes	203691|Spirochaetes	H	Alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
CMS1_k127_5154592_8	158190.SpiGrapes_1547	1.424e-126	411.0	COG1609@1|root,COG1609@2|Bacteria,2J7IG@203691|Spirochaetes	203691|Spirochaetes	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_5154592_7	158190.SpiGrapes_0260	1.497e-136	442.0	COG1079@1|root,COG1079@2|Bacteria,2J646@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_5154592_6	158189.SpiBuddy_1538	4.376e-142	460.0	COG4603@1|root,COG4603@2|Bacteria,2J6ER@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_5154592_2	97138.C820_02764	7.353e-218	687.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_5154592_5	158190.SpiGrapes_0257	3e-170	543.0	COG1744@1|root,COG1744@2|Bacteria,2J66P@203691|Spirochaetes	203691|Spirochaetes	S	ABC-type transport system, periplasmic component surface lipoprotein	bmpD	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
CMS1_k127_5154592_9	158190.SpiGrapes_0253	5.607e-108	364.0	29JST@1|root,306Q4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5174677_3	158190.SpiGrapes_1484	1.203e-177	559.0	COG0825@1|root,COG0825@2|Bacteria,2J5PA@203691|Spirochaetes	203691|Spirochaetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
CMS1_k127_5174677_7	158189.SpiBuddy_0475	2.222e-116	381.0	COG0777@1|root,COG0777@2|Bacteria,2J5W0@203691|Spirochaetes	203691|Spirochaetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
CMS1_k127_5174677_0	158190.SpiGrapes_1486	1.058e-239	747.0	COG0439@1|root,COG0439@2|Bacteria,2J5D2@203691|Spirochaetes	203691|Spirochaetes	I	Biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS1_k127_5174677_12	158190.SpiGrapes_1487	3.603e-60	211.0	COG0511@1|root,COG0511@2|Bacteria,2J83W@203691|Spirochaetes	203691|Spirochaetes	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
CMS1_k127_5174677_4	158190.SpiGrapes_1488	5.684e-174	548.0	COG0332@1|root,COG0332@2|Bacteria,2J6DC@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS1_k127_5174677_11	665571.STHERM_c21550	5.17e-63	229.0	COG0331@1|root,COG0331@2|Bacteria,2J5E6@203691|Spirochaetes	203691|Spirochaetes	I	Malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
CMS1_k127_5174677_5	158190.SpiGrapes_1490	1.31e-126	408.0	COG1028@1|root,COG1028@2|Bacteria,2J6CJ@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS1_k127_5174677_1	158190.SpiGrapes_1491	1.569e-234	730.0	COG0304@1|root,COG0304@2|Bacteria,2J5H7@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS1_k127_5174677_10	158190.SpiGrapes_1492	1.741e-75	257.0	COG0764@1|root,COG0764@2|Bacteria,2J7PK@203691|Spirochaetes	203691|Spirochaetes	I	dehydratase	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
CMS1_k127_5174677_2	158190.SpiGrapes_1493	3.532e-215	676.0	COG3007@1|root,COG3007@2|Bacteria,2J582@203691|Spirochaetes	203691|Spirochaetes	I	Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA)	fabV	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050343,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.44,1.3.1.9	ko:K00209	ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212	M00083	R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase
CMS1_k127_5174677_9	1122963.AUHB01000004_gene3050	6.806e-93	316.0	COG2017@1|root,COG2017@2|Bacteria,1MVUY@1224|Proteobacteria,2U3XD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
CMS1_k127_5174677_8	1122963.AUHB01000004_gene3051	5.14e-106	351.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TW5I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	MA20_14320	-	-	ko:K10439,ko:K17202,ko:K17205,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00590,M00591,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.15,3.A.1.2.16,3.A.1.2.19	-	-	Peripla_BP_4
CMS1_k127_5174677_6	1122963.AUHB01000004_gene3052	1.433e-118	388.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2U0D6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS1_k127_5188580_1	158787.BSCA_0461	1.717e-138	447.0	COG1621@1|root,COG1621@2|Bacteria,2H3S0@201174|Actinobacteria,4D05M@85004|Bifidobacteriales	201174|Actinobacteria	G	Glycosyl hydrolases family 32	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32C,Glyco_hydro_32N
CMS1_k127_5188580_0	1304866.K413DRAFT_2980	6.541e-175	558.0	COG0477@1|root,COG2814@2|Bacteria,1UHUR@1239|Firmicutes,25E36@186801|Clostridia,36FBN@31979|Clostridiaceae	186801|Clostridia	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
CMS1_k127_5188580_7	158189.SpiBuddy_0326	2.065e-29	120.0	COG3743@1|root,COG3743@2|Bacteria,2JBBX@203691|Spirochaetes	203691|Spirochaetes	S	TfoX C-terminal domain	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_C
CMS1_k127_5188580_6	1226325.HMPREF1548_04629	3.371e-37	141.0	COG1476@1|root,COG1476@2|Bacteria,1UHV6@1239|Firmicutes,25E3W@186801|Clostridia,36UHK@31979|Clostridiaceae	186801|Clostridia	K	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn_ribbon_2
CMS1_k127_5188580_2	1121344.JHZO01000001_gene536	7.242e-96	322.0	COG2378@1|root,COG2378@2|Bacteria,1TS78@1239|Firmicutes,25C7I@186801|Clostridia,3WIMZ@541000|Ruminococcaceae	186801|Clostridia	K	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL,Zn_ribbon_2
CMS1_k127_5188580_5	646529.Desaci_0177	2.547e-43	163.0	COG1246@1|root,COG1246@2|Bacteria,1VE50@1239|Firmicutes,24PV0@186801|Clostridia	186801|Clostridia	E	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS1_k127_5188580_4	1027292.HMPREF9372_0014	3.153e-51	186.0	COG1247@1|root,COG1247@2|Bacteria,1V3XH@1239|Firmicutes,4HKIU@91061|Bacilli	91061|Bacilli	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_5188580_3	158190.SpiGrapes_0773	2.611e-84	287.0	COG0671@1|root,COG0671@2|Bacteria,2J83Z@203691|Spirochaetes	203691|Spirochaetes	I	PFAM PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
CMS1_k127_5197633_0	573413.Spirs_2957	1.037e-132	426.0	COG2186@1|root,COG2186@2|Bacteria,2JB16@203691|Spirochaetes	203691|Spirochaetes	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_5197633_1	1280686.AUKE01000009_gene881	1.874e-12	71.0	COG5421@1|root,COG5421@2|Bacteria,1V4M5@1239|Firmicutes,24F9B@186801|Clostridia	186801|Clostridia	L	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS1_k127_5225234_5	573413.Spirs_1663	2.013e-59	207.0	COG1129@1|root,COG1129@2|Bacteria,2J79M@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1129 ABC-type sugar transport system ATPase component	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
CMS1_k127_5225234_3	760011.Spico_0080	8.356e-136	441.0	COG0673@1|root,COG0673@2|Bacteria,2J6J2@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG0673 dehydrogenase and related protein	-	-	1.1.1.370	ko:K16043	ko00562,ko01120,map00562,map01120	-	R09953	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_5225234_1	1123274.KB899413_gene759	8.658e-148	474.0	COG1172@1|root,COG1172@2|Bacteria,2J5VX@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1172 Ribose xylose arabinose galactoside ABC-type transport systems permease components	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS1_k127_5225234_2	760011.Spico_0078	1.206e-145	468.0	COG1879@1|root,COG1879@2|Bacteria,2J74G@203691|Spirochaetes	203691|Spirochaetes	G	D-ribose-binding periplasmic protein	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
CMS1_k127_5225234_4	937777.Deipe_1305	3.608e-89	305.0	COG0673@1|root,COG0673@2|Bacteria,1WM1E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_5225234_0	158190.SpiGrapes_3139	2.343e-185	583.0	COG1609@1|root,COG1609@2|Bacteria,2J6Q3@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_5225234_6	1125699.HMPREF9194_01702	9.374e-13	68.0	COG2207@1|root,COG2207@2|Bacteria,2J67C@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Peripla_BP_3
CMS1_k127_5227854_2	158190.SpiGrapes_1086	3.917e-62	216.0	2FJEQ@1|root,340KN@2|Bacteria,2J82M@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5227854_0	158190.SpiGrapes_1085	3.36e-322	996.0	2EQUJ@1|root,33IEB@2|Bacteria,2JBG7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5227854_1	158190.SpiGrapes_1084	4.37e-118	384.0	COG0463@1|root,COG0463@2|Bacteria,2J8KW@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K16698	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
CMS1_k127_5230174_6	158189.SpiBuddy_0499	1.104e-118	393.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_5230174_3	1122915.AUGY01000034_gene998	3.033e-129	422.0	COG0673@1|root,COG0673@2|Bacteria,1TNYR@1239|Firmicutes,4HAZU@91061|Bacilli,26UFG@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_5230174_1	158190.SpiGrapes_1543	1.14e-183	583.0	COG1653@1|root,COG1653@2|Bacteria,2J682@203691|Spirochaetes	203691|Spirochaetes	G	extracellular solute-binding	-	-	-	ko:K02027,ko:K17241	ko02010,map02010	M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.39	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_5230174_9	1298920.KI911353_gene216	3.877e-76	265.0	COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,249MK@186801|Clostridia	186801|Clostridia	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K02025,ko:K17242	ko02010,map02010	M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.39	-	-	BPD_transp_1
CMS1_k127_5230174_4	158190.SpiGrapes_1545	1.205e-126	409.0	COG0395@1|root,COG0395@2|Bacteria,2J7XG@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K17243	ko02010,map02010	M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.39	-	-	BPD_transp_1
CMS1_k127_5230174_0	158189.SpiBuddy_0400	1.254e-274	865.0	COG1501@1|root,COG1501@2|Bacteria,2J73G@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
CMS1_k127_5230174_11	278957.ABEA03000104_gene329	3.353e-45	177.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N
CMS1_k127_5230174_10	1499967.BAYZ01000057_gene4726	3.213e-74	259.0	COG1082@1|root,COG1082@2|Bacteria,2NRTI@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS1_k127_5230174_5	158189.SpiBuddy_0399	4.746e-124	406.0	COG1609@1|root,COG1609@2|Bacteria,2J7IG@203691|Spirochaetes	203691|Spirochaetes	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_5230174_7	158190.SpiGrapes_1671	1.215e-97	324.0	COG1305@1|root,COG1305@2|Bacteria,2J6K6@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS1_k127_5230174_2	158190.SpiGrapes_1670	6.949e-137	440.0	COG0169@1|root,COG0169@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
CMS1_k127_5230174_8	158190.SpiGrapes_1669	3.817e-96	317.0	COG0250@1|root,COG0250@2|Bacteria,2J829@203691|Spirochaetes	203691|Spirochaetes	K	Transcription antitermination protein, NusG	-	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
CMS1_k127_5254374_1	1382304.JNIL01000001_gene1855	1.09e-06	53.0	COG1484@1|root,COG1484@2|Bacteria,1TQBX@1239|Firmicutes,4HCFH@91061|Bacilli	91061|Bacilli	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
CMS1_k127_5254374_2	883109.HMPREF0380_00939	3.363e-06	50.0	COG1943@1|root,COG1943@2|Bacteria,1V1CM@1239|Firmicutes,24BK2@186801|Clostridia	186801|Clostridia	L	PFAM transposase IS200-family protein	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CMS1_k127_5254374_0	1121115.AXVN01000186_gene2049	2.225e-286	900.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,3XYUA@572511|Blautia	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	bglB	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CMS1_k127_5255788_0	158190.SpiGrapes_0109	1.099e-160	509.0	COG0812@1|root,COG0812@2|Bacteria,2J5SE@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
CMS1_k127_5255788_1	158190.SpiGrapes_0110	8.119e-160	504.0	COG0215@1|root,COG0215@2|Bacteria,2J618@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
CMS1_k127_5262819_5	158190.SpiGrapes_0171	8.714e-65	223.0	COG0346@1|root,COG0346@2|Bacteria,2JA7S@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Glyoxalase Bleomycin resistance protein Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
CMS1_k127_5262819_3	158190.SpiGrapes_0170	2.113e-140	451.0	COG1079@1|root,COG1079@2|Bacteria,2J81E@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_5262819_4	573413.Spirs_0554	2.018e-76	268.0	COG4603@1|root,COG4603@2|Bacteria,2J7BS@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_5262819_0	158190.SpiGrapes_0168	7.228e-231	724.0	COG3845@1|root,COG3845@2|Bacteria	2|Bacteria	P	ABC transporter	rbsA	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_5262819_2	158190.SpiGrapes_0167	2.421e-172	546.0	COG1744@1|root,COG1744@2|Bacteria,2J572@203691|Spirochaetes	203691|Spirochaetes	S	Basic membrane protein	tpn38b	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
CMS1_k127_5262819_1	158190.SpiGrapes_0165	2.318e-227	711.0	COG1070@1|root,COG1070@2|Bacteria,2J7TG@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_5262819_6	158190.SpiGrapes_0164	5.13e-34	132.0	COG1063@1|root,COG1063@2|Bacteria,2J6S3@203691|Spirochaetes	203691|Spirochaetes	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_5264963_1	663278.Ethha_1174	1.223e-173	552.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia	186801|Clostridia	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.113,2.6.1.55,2.6.1.62,2.6.1.77	ko:K00833,ko:K03851,ko:K12256,ko:K15372	ko00330,ko00410,ko00430,ko00780,ko01100,map00330,map00410,map00430,map00780,map01100	M00123,M00573,M00577	R00908,R01684,R03231,R05652,R08714	RC00006,RC00008,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS1_k127_5264963_0	1449050.JNLE01000003_gene2649	3.213e-208	657.0	COG0167@1|root,COG0493@1|root,COG1146@1|root,COG0167@2|Bacteria,COG0493@2|Bacteria,COG1146@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia,36EA4@31979|Clostridiaceae	186801|Clostridia	C	dihydroorotate dehydrogenase	preA	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_20,Fer4_21,Fer4_6
CMS1_k127_5280300_6	573413.Spirs_2747	1.542e-85	287.0	COG5012@1|root,COG5012@2|Bacteria,2JBHI@203691|Spirochaetes	203691|Spirochaetes	S	Dimethylamine corrinoid protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
CMS1_k127_5280300_1	573413.Spirs_2748	5.225e-213	668.0	COG0407@1|root,COG0407@2|Bacteria,2J8ZX@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
CMS1_k127_5280300_7	573413.Spirs_2749	2.918e-53	200.0	COG0523@1|root,COG0523@2|Bacteria	2|Bacteria	P	cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
CMS1_k127_5280300_8	1123274.KB899418_gene2343	2.684e-42	163.0	COG1410@1|root,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
CMS1_k127_5280300_10	158189.SpiBuddy_0136	1.817e-05	49.0	COG0179@1|root,COG0179@2|Bacteria,2J89U@203691|Spirochaetes	203691|Spirochaetes	Q	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
CMS1_k127_5280300_0	545696.HOLDEFILI_00545	4.231e-268	843.0	COG4692@1|root,COG4692@2|Bacteria,1UJSZ@1239|Firmicutes,3VS85@526524|Erysipelotrichia	526524|Erysipelotrichia	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5280300_4	545696.HOLDEFILI_00544	5.414e-134	432.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,3VQAD@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
CMS1_k127_5280300_5	1211819.CALK01000029_gene1987	6.071e-125	409.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,3VTHY@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Branched-chain amino acid ABC transporter, permease protein	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
CMS1_k127_5280300_2	1230342.CTM_18116	5.342e-145	476.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_5280300_3	545696.HOLDEFILI_00541	3.238e-141	457.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,3VR8A@526524|Erysipelotrichia	526524|Erysipelotrichia	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
CMS1_k127_5280300_9	1211819.CALK01000029_gene1993	3.143e-39	154.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Fer4_5,HTH_Crp_2,Sigma54_activ_2,Sigma54_activat,cNMP_binding
CMS1_k127_5301547_0	158190.SpiGrapes_1006	3.53e-313	964.0	COG2217@1|root,COG2217@2|Bacteria,2J60R@203691|Spirochaetes	203691|Spirochaetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	zntA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CMS1_k127_5301547_1	158190.SpiGrapes_1008	3.657e-153	492.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_5308783_1	158190.SpiGrapes_1772	1.955e-141	451.0	COG0179@1|root,COG0179@2|Bacteria,2J89U@203691|Spirochaetes	203691|Spirochaetes	Q	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
CMS1_k127_5308783_0	158190.SpiGrapes_1771	6.153e-235	728.0	COG2265@1|root,COG2265@2|Bacteria,2J8H3@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
CMS1_k127_5308783_2	332101.JIBU02000048_gene3790	1.319e-73	248.0	COG2207@1|root,COG2207@2|Bacteria,1TQDS@1239|Firmicutes,24907@186801|Clostridia,36ENI@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, arac family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS1_k127_5330354_1	1120746.CCNL01000012_gene1913	4.129e-184	578.0	COG0535@1|root,COG0535@2|Bacteria,2NQMX@2323|unclassified Bacteria	2|Bacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS1_k127_5330354_2	158190.SpiGrapes_0757	9.263e-166	526.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,2J5BJ@203691|Spirochaetes	203691|Spirochaetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
CMS1_k127_5330354_3	158190.SpiGrapes_0756	2.715e-127	413.0	COG3752@1|root,COG3752@2|Bacteria,2J9PV@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
CMS1_k127_5330354_4	158190.SpiGrapes_0754	1.191e-43	164.0	2DPK9@1|root,332H1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5330354_0	158190.SpiGrapes_0753	1.08e-251	781.0	COG0438@1|root,COG1409@1|root,COG0438@2|Bacteria,COG1409@2|Bacteria,2J7E2@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS1_k127_5339286_2	158189.SpiBuddy_2517	6.637e-132	426.0	COG0747@1|root,COG0747@2|Bacteria,2J86R@203691|Spirochaetes	203691|Spirochaetes	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS1_k127_5339286_0	1395587.P364_0121900	4.06e-144	468.0	COG2377@1|root,COG2377@2|Bacteria,1TSBU@1239|Firmicutes,4HAYA@91061|Bacilli,26SDJ@186822|Paenibacillaceae	91061|Bacilli	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
CMS1_k127_5339286_1	158189.SpiBuddy_2519	3.787e-133	433.0	COG2103@1|root,COG2103@2|Bacteria,2J5NI@203691|Spirochaetes	203691|Spirochaetes	H	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
CMS1_k127_5339286_3	158189.SpiBuddy_2520	7.214e-111	367.0	COG1737@1|root,COG1737@2|Bacteria,2J8DG@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix domain, rpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
CMS1_k127_5339286_4	158190.SpiGrapes_2751	9.644e-58	202.0	COG1609@1|root,COG1609@2|Bacteria,2J6P1@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_5371975_11	158190.SpiGrapes_1089	1.609e-51	183.0	COG2973@1|root,COG2973@2|Bacteria,2JBFI@203691|Spirochaetes	203691|Spirochaetes	K	TIGRFAM trp operon repressor, proteobacterial	-	-	-	ko:K03720	-	-	-	-	ko00000,ko03000	-	-	-	Trp_repressor
CMS1_k127_5371975_9	158190.SpiGrapes_1090	2.379e-138	444.0	COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,2J5X5@203691|Spirochaetes	203691|Spirochaetes	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
CMS1_k127_5371975_4	158190.SpiGrapes_1091	3.967e-170	542.0	COG0667@1|root,COG0667@2|Bacteria,2JAJ2@203691|Spirochaetes	203691|Spirochaetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS1_k127_5371975_7	158190.SpiGrapes_1093	7.606e-148	473.0	COG0679@1|root,COG0679@2|Bacteria,2JB5Y@203691|Spirochaetes	203691|Spirochaetes	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	-
CMS1_k127_5371975_2	158190.SpiGrapes_1094	4.962e-269	830.0	COG2115@1|root,COG2115@2|Bacteria,2J5IA@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the xylose isomerase family	xylA	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	-
CMS1_k127_5371975_3	158190.SpiGrapes_1095	1.774e-265	825.0	COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_5371975_6	158190.SpiGrapes_1096	1.002e-154	490.0	COG4977@1|root,COG4977@2|Bacteria,2J7K1@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
CMS1_k127_5371975_8	158190.SpiGrapes_1098	3.105e-143	459.0	COG0524@1|root,COG0524@2|Bacteria,2J6EF@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS1_k127_5371975_0	158190.SpiGrapes_1099	1.665e-298	919.0	COG1502@1|root,COG1502@2|Bacteria,2J62N@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
CMS1_k127_5371975_10	158190.SpiGrapes_1100	8.577e-98	321.0	COG1636@1|root,COG1636@2|Bacteria,2J8F1@203691|Spirochaetes	203691|Spirochaetes	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
CMS1_k127_5371975_5	158190.SpiGrapes_1101	1.559e-168	535.0	COG0457@1|root,COG0457@2|Bacteria	158190.SpiGrapes_1101|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5371975_1	158190.SpiGrapes_1102	7.977e-296	924.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
CMS1_k127_5406358_5	158190.SpiGrapes_2322	9.641e-66	225.0	COG1274@1|root,COG1274@2|Bacteria,2J5BB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
CMS1_k127_5406358_4	158190.SpiGrapes_2321	3.606e-100	329.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_5406358_1	158190.SpiGrapes_2320	4.515e-250	779.0	COG2211@1|root,COG2211@2|Bacteria,2J6VC@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter	-	-	-	ko:K11104,ko:K16209,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2,2.A.2.1,2.A.2.2	-	-	MFS_2
CMS1_k127_5406358_0	158190.SpiGrapes_2319	0.0	1279.0	COG0826@1|root,COG0826@2|Bacteria,2J667@203691|Spirochaetes	203691|Spirochaetes	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
CMS1_k127_5406358_6	158190.SpiGrapes_2317	1.226e-58	209.0	COG1051@1|root,COG1051@2|Bacteria,2JBGW@203691|Spirochaetes	203691|Spirochaetes	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS1_k127_5406358_2	158190.SpiGrapes_2315	9.283e-210	654.0	COG0136@1|root,COG0136@2|Bacteria,2J5ZP@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the aspartate-semialdehyde dehydrogenase family	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS1_k127_5406358_3	158190.SpiGrapes_2314	1.122e-102	334.0	COG0347@1|root,COG0347@2|Bacteria,2J7GB@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	P-II
CMS1_k127_5428198_0	575593.HMPREF0491_01137	1.948e-85	299.0	COG1653@1|root,COG1653@2|Bacteria,1TQ75@1239|Firmicutes,24BNJ@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
CMS1_k127_5450572_1	158190.SpiGrapes_0431	0.0	1076.0	COG0449@1|root,COG0449@2|Bacteria,2J587@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
CMS1_k127_5450572_7	158190.SpiGrapes_0434	9.66e-43	159.0	COG1725@1|root,COG1725@2|Bacteria,2J92C@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
CMS1_k127_5450572_4	158190.SpiGrapes_0435	4.384e-130	420.0	COG1694@1|root,COG3956@2|Bacteria,2J5HG@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM MazG family protein	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
CMS1_k127_5450572_5	158190.SpiGrapes_0436	2.157e-102	336.0	COG0490@1|root,COG1725@1|root,COG0490@2|Bacteria,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	busR	-	-	ko:K03281,ko:K07979	-	-	-	-	ko00000,ko03000	2.A.49	-	-	GntR,TrkA_C
CMS1_k127_5450572_2	158190.SpiGrapes_0437	4.373e-270	839.0	COG0747@1|root,COG0747@2|Bacteria,2J86R@203691|Spirochaetes	203691|Spirochaetes	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS1_k127_5450572_3	158190.SpiGrapes_0438	1.766e-178	563.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_5450572_6	1408418.JNJH01000055_gene1545	3.065e-63	227.0	COG1173@1|root,COG1173@2|Bacteria,1R7UQ@1224|Proteobacteria,2U4Q2@28211|Alphaproteobacteria,2JV9K@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_5450572_0	158190.SpiGrapes_0440	0.0	1168.0	COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	dppF	-	-	ko:K02031,ko:K02032,ko:K10823,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_5468042_1	158190.SpiGrapes_3014	1.142e-119	389.0	COG0546@1|root,COG0546@2|Bacteria,2J9ET@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_5468042_0	158190.SpiGrapes_3015	2.297e-131	421.0	COG1573@1|root,COG1573@2|Bacteria,2JA8F@203691|Spirochaetes	203691|Spirochaetes	L	PFAM Uracil DNA glycosylase superfamily	-	-	-	ko:K10800	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS1_k127_5468042_2	158190.SpiGrapes_3016	1.597e-110	364.0	COG1947@1|root,COG1947@2|Bacteria,2J7N4@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
CMS1_k127_5468042_3	158190.SpiGrapes_3017	1.994e-43	160.0	COG2088@1|root,COG2088@2|Bacteria,2J7XR@203691|Spirochaetes	203691|Spirochaetes	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
CMS1_k127_5493425_1	411471.SUBVAR_04885	1.507e-121	396.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,3WI9R@541000|Ruminococcaceae	186801|Clostridia	M	Mannose-1-phosphate guanylyltransferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
CMS1_k127_5493425_0	994573.T472_0204475	8.545e-128	419.0	COG5421@1|root,COG5421@2|Bacteria,1UHBN@1239|Firmicutes,249CH@186801|Clostridia,36M6Z@31979|Clostridiaceae	186801|Clostridia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS1_k127_5493425_2	457412.RSAG_00969	5.305e-06	53.0	2EJPA@1|root,33DE4@2|Bacteria,1VPMV@1239|Firmicutes,24VGY@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5528855_21	657322.FPR_10240	1.793e-153	489.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WN2S@541000|Ruminococcaceae	186801|Clostridia	P	Oligopeptide/dipeptide transporter, C-terminal region	oppF	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_5528855_18	657322.FPR_10230	1.673e-176	558.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WHP6@541000|Ruminococcaceae	186801|Clostridia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_5528855_20	718252.FP2_31120	3.831e-154	496.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3WIY9@541000|Ruminococcaceae	186801|Clostridia	P	N-terminal TM domain of oligopeptide transport permease C	oppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
CMS1_k127_5528855_23	1235793.C809_00893	1.993e-140	452.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,27KXN@186928|unclassified Lachnospiraceae	186801|Clostridia	EP	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
CMS1_k127_5528855_15	748224.HMPREF9436_00015	2.442e-229	722.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,3WSCF@541000|Ruminococcaceae	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
CMS1_k127_5528855_34	158190.SpiGrapes_2059	5.921e-88	292.0	COG0597@1|root,COG0597@2|Bacteria,2J7QV@203691|Spirochaetes	203691|Spirochaetes	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
CMS1_k127_5528855_24	158190.SpiGrapes_2062	2.877e-140	449.0	COG3884@1|root,COG3884@2|Bacteria,2J7X9@203691|Spirochaetes	203691|Spirochaetes	I	Acyl-ACP thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-ACP_TE
CMS1_k127_5528855_30	158190.SpiGrapes_2063	5.59e-102	333.0	COG0742@1|root,COG0742@2|Bacteria,2J7B5@203691|Spirochaetes	203691|Spirochaetes	L	RNA methyltransferase, RsmD family	yhhF	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
CMS1_k127_5528855_1	158190.SpiGrapes_2064	0.0	1186.0	COG1200@1|root,COG1200@2|Bacteria,2J5ET@203691|Spirochaetes	203691|Spirochaetes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
CMS1_k127_5528855_28	158190.SpiGrapes_2065	6.926e-108	353.0	COG0762@1|root,COG0762@2|Bacteria,2J81F@203691|Spirochaetes	203691|Spirochaetes	S	PFAM YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
CMS1_k127_5528855_0	158190.SpiGrapes_2066	0.0	2148.0	COG0587@1|root,COG0587@2|Bacteria,2J5B5@203691|Spirochaetes	203691|Spirochaetes	L	DNA-directed DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
CMS1_k127_5528855_19	158190.SpiGrapes_2067	3.847e-164	520.0	COG1319@1|root,COG1319@2|Bacteria,2J8FR@203691|Spirochaetes	203691|Spirochaetes	C	FAD binding domain in molybdopterin dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_5
CMS1_k127_5528855_40	1480694.DC28_11600	1.056e-15	87.0	COG2080@1|root,COG2080@2|Bacteria,2J7WE@203691|Spirochaetes	203691|Spirochaetes	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
CMS1_k127_5528855_6	158190.SpiGrapes_2069	0.0	1017.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
CMS1_k127_5528855_2	158190.SpiGrapes_2070	0.0	1146.0	COG0272@1|root,COG0272@2|Bacteria,2J57Q@203691|Spirochaetes	203691|Spirochaetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CMS1_k127_5528855_13	158190.SpiGrapes_2071	3.631e-241	752.0	COG0436@1|root,COG0436@2|Bacteria,2J5R0@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS1_k127_5528855_10	158190.SpiGrapes_2073	4.003e-287	882.0	COG0205@1|root,COG0205@2|Bacteria,2J6KH@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
CMS1_k127_5528855_11	158190.SpiGrapes_2074	4.889e-286	884.0	COG0166@1|root,COG0166@2|Bacteria,2J5I6@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
CMS1_k127_5528855_33	158190.SpiGrapes_2075	2.632e-91	304.0	COG1438@1|root,COG1438@2|Bacteria,2J7NJ@203691|Spirochaetes	203691|Spirochaetes	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
CMS1_k127_5528855_32	158190.SpiGrapes_2076	3.763e-99	326.0	COG1704@1|root,COG1704@2|Bacteria,2J65U@203691|Spirochaetes	203691|Spirochaetes	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
CMS1_k127_5528855_8	158190.SpiGrapes_2077	3.178e-311	962.0	COG4907@1|root,COG4907@2|Bacteria	2|Bacteria	P	membrane protein (DUF2207)	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2207
CMS1_k127_5528855_39	158189.SpiBuddy_2902	1.212e-23	104.0	COG4728@1|root,COG4728@2|Bacteria	2|Bacteria	FJ	Protein conserved in bacteria	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	DUF1653
CMS1_k127_5528855_37	158190.SpiGrapes_2079	3.633e-49	178.0	COG0724@1|root,COG0724@2|Bacteria,2J8UF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS1_k127_5528855_31	158190.SpiGrapes_2080	9.795e-102	337.0	COG0170@1|root,COG0170@2|Bacteria	2|Bacteria	I	dolichyl monophosphate biosynthetic process	sec59	GO:0003674,GO:0003824,GO:0006066,GO:0006629,GO:0006720,GO:0006721,GO:0006766,GO:0006775,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009987,GO:0010189,GO:0010276,GO:0016101,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017144,GO:0018130,GO:0033306,GO:0034308,GO:0042360,GO:0042362,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1903173	2.7.1.182	ko:K18678	-	-	R10659	RC00002,RC00017	ko00000,ko01000	-	-	-	DUF92
CMS1_k127_5528855_25	158190.SpiGrapes_2081	7.908e-130	426.0	COG1836@1|root,COG1836@2|Bacteria,2J875@203691|Spirochaetes	203691|Spirochaetes	I	PFAM Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
CMS1_k127_5528855_7	158190.SpiGrapes_2082	0.0	1003.0	COG0459@1|root,COG0459@2|Bacteria,2J5CK@203691|Spirochaetes	203691|Spirochaetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS1_k127_5528855_35	158190.SpiGrapes_2083	8.496e-72	244.0	COG1862@1|root,COG1862@2|Bacteria,2J8D6@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
CMS1_k127_5528855_5	158190.SpiGrapes_2084	0.0	1024.0	COG0342@1|root,COG0342@2|Bacteria,2J5UV@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS1_k127_5528855_17	158190.SpiGrapes_2085	1.945e-203	638.0	COG0341@1|root,COG0341@2|Bacteria,2J5N7@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS1_k127_5528855_26	158190.SpiGrapes_2086	2.759e-129	419.0	COG0761@1|root,COG0761@2|Bacteria,2J56Z@203691|Spirochaetes	203691|Spirochaetes	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
CMS1_k127_5528855_27	158190.SpiGrapes_2087	7.962e-126	404.0	COG2344@1|root,COG2344@2|Bacteria,2J67B@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS1_k127_5528855_38	158190.SpiGrapes_2088	1.845e-44	162.0	COG1905@1|root,COG1905@2|Bacteria,2J9FS@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
CMS1_k127_5528855_4	158190.SpiGrapes_2089	0.0	1078.0	COG1145@1|root,COG4624@1|root,COG1145@2|Bacteria,COG4624@2|Bacteria,2J73J@203691|Spirochaetes	203691|Spirochaetes	C	PAS PAC sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,PAS_8
CMS1_k127_5528855_14	158190.SpiGrapes_2090	1.662e-233	725.0	COG2208@1|root,COG2208@2|Bacteria,2J6CG@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
CMS1_k127_5528855_41	665571.STHERM_c12340	8.236e-10	63.0	COG1905@1|root,COG1905@2|Bacteria,2J9F5@203691|Spirochaetes	203691|Spirochaetes	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS1_k127_5528855_9	158190.SpiGrapes_2092	2.993e-306	940.0	COG1143@1|root,COG1941@1|root,COG4624@1|root,COG1143@2|Bacteria,COG1941@2|Bacteria,COG4624@2|Bacteria,2J6BD@203691|Spirochaetes	203691|Spirochaetes	C	Fe-hydrogenase large subunit family protein	-	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_lg_C,Fer4
CMS1_k127_5528855_36	158190.SpiGrapes_2093	2.751e-69	238.0	COG1956@1|root,COG1956@2|Bacteria,2J8K8@203691|Spirochaetes	203691|Spirochaetes	T	GAF domain	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
CMS1_k127_5528855_3	158190.SpiGrapes_2094	0.0	1116.0	COG0441@1|root,COG0441@2|Bacteria,2J5ID@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
CMS1_k127_5528855_12	158190.SpiGrapes_2095	7.461e-274	848.0	COG2317@1|root,COG2317@2|Bacteria,2J6XW@203691|Spirochaetes	203691|Spirochaetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
CMS1_k127_5528855_29	158190.SpiGrapes_2096	3.69e-106	346.0	COG0558@1|root,COG0558@2|Bacteria,2J7NA@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS1_k127_5528855_22	158190.SpiGrapes_2097	2.383e-144	462.0	COG0561@1|root,COG0561@2|Bacteria,2J7IJ@203691|Spirochaetes	203691|Spirochaetes	M	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Hydrolase_3
CMS1_k127_5549433_11	243231.GSU3405	4.494e-46	169.0	COG0765@1|root,COG0765@2|Bacteria,1MWF0@1224|Proteobacteria,42NEI@68525|delta/epsilon subdivisions,2WJP9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
CMS1_k127_5549433_4	158190.SpiGrapes_0686	5.28e-139	444.0	COG1126@1|root,COG1126@2|Bacteria,2J5V5@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type polar amino acid transport system ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
CMS1_k127_5549433_7	158190.SpiGrapes_0687	1.295e-112	367.0	COG1272@1|root,COG1272@2|Bacteria,2J5IS@203691|Spirochaetes	203691|Spirochaetes	S	channel protein, hemolysin III family	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
CMS1_k127_5549433_9	158190.SpiGrapes_0688	6.112e-86	291.0	COG0526@1|root,COG0526@2|Bacteria,2J8ET@203691|Spirochaetes	203691|Spirochaetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
CMS1_k127_5549433_6	158190.SpiGrapes_0689	7.433e-121	390.0	COG0785@1|root,COG0785@2|Bacteria,2J640@203691|Spirochaetes	203691|Spirochaetes	O	cytochrome c biogenesis protein	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
CMS1_k127_5549433_5	158190.SpiGrapes_0690	1.053e-132	428.0	COG0144@1|root,COG0144@2|Bacteria,2J77F@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.178	ko:K11392,ko:K21970	-	-	-	-	ko00000,ko01000,ko03009,ko03029	-	-	-	Methyltr_RsmB-F
CMS1_k127_5549433_2	158190.SpiGrapes_0691	9.91e-199	624.0	COG1143@1|root,COG2006@1|root,COG1143@2|Bacteria,COG2006@2|Bacteria,2J60I@203691|Spirochaetes	203691|Spirochaetes	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
CMS1_k127_5549433_8	158190.SpiGrapes_0692	2.381e-88	293.0	COG2426@1|root,COG2426@2|Bacteria,2J7NY@203691|Spirochaetes	203691|Spirochaetes	S	small multi-drug export	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
CMS1_k127_5549433_0	158190.SpiGrapes_0693	0.0	1256.0	COG0210@1|root,COG0210@2|Bacteria,2J5T4@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CMS1_k127_5549433_3	158190.SpiGrapes_0697	1.374e-166	531.0	COG3641@1|root,COG3641@2|Bacteria,2J5VV@203691|Spirochaetes	203691|Spirochaetes	S	Phosphotransferase system, EIIC	-	-	-	ko:K07035	-	-	-	-	ko00000	-	-	-	PTS_EIIC_2
CMS1_k127_5549433_1	158190.SpiGrapes_0699	5.343e-259	807.0	COG0366@1|root,COG0366@2|Bacteria,2J9KV@203691|Spirochaetes	203691|Spirochaetes	G	Alpha amylase catalytic	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase
CMS1_k127_5564357_6	158190.SpiGrapes_1244	5.582e-27	110.0	COG0245@1|root,COG0245@2|Bacteria,2J7UY@203691|Spirochaetes	203691|Spirochaetes	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
CMS1_k127_5564357_3	158190.SpiGrapes_1243	1.052e-149	477.0	COG1211@1|root,COG1211@2|Bacteria,2J6JT@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the IspD TarI cytidylyltransferase family. IspD subfamily	ispD	-	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
CMS1_k127_5564357_5	158190.SpiGrapes_1242	5.275e-96	317.0	COG1329@1|root,COG1329@2|Bacteria,2J7TP@203691|Spirochaetes	203691|Spirochaetes	K	Transcription factor	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
CMS1_k127_5564357_0	158190.SpiGrapes_1241	2.253e-295	911.0	COG1640@1|root,COG1640@2|Bacteria,2J5U4@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
CMS1_k127_5564357_2	158190.SpiGrapes_1240	3.189e-157	501.0	COG0095@1|root,COG0095@2|Bacteria,2J7XV@203691|Spirochaetes	203691|Spirochaetes	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
CMS1_k127_5564357_4	158190.SpiGrapes_1239	1.222e-110	362.0	COG1385@1|root,COG1385@2|Bacteria,2J81V@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
CMS1_k127_5564357_1	158190.SpiGrapes_1238	3.454e-167	527.0	COG1351@1|root,COG1351@2|Bacteria,2J68R@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
CMS1_k127_5572550_0	158190.SpiGrapes_2322	0.0	1017.0	COG1274@1|root,COG1274@2|Bacteria,2J5BB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
CMS1_k127_5572550_3	158190.SpiGrapes_2323	2.884e-161	513.0	COG2378@1|root,COG2378@2|Bacteria,2J653@203691|Spirochaetes	203691|Spirochaetes	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	WYL
CMS1_k127_5572550_1	158190.SpiGrapes_2326	1.539e-250	779.0	COG2233@1|root,COG2233@2|Bacteria,2J5WY@203691|Spirochaetes	203691|Spirochaetes	F	Uracil permease	-	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
CMS1_k127_5572550_7	158189.SpiBuddy_2715	5.913e-117	384.0	COG0349@1|root,COG0349@2|Bacteria,2J80E@203691|Spirochaetes	203691|Spirochaetes	L	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
CMS1_k127_5572550_5	158190.SpiGrapes_2329	1.485e-152	488.0	COG1893@1|root,COG1893@2|Bacteria,2J72D@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
CMS1_k127_5572550_4	158190.SpiGrapes_2330	1.188e-157	505.0	COG2195@1|root,COG2195@2|Bacteria	2|Bacteria	E	Cleaves the N-terminal amino acid of tripeptides	MA20_17715	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28,Peptidase_M42
CMS1_k127_5572550_2	158190.SpiGrapes_2331	2.052e-187	588.0	COG0667@1|root,COG0667@2|Bacteria,2J6C3@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Aldo keto reductase family	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
CMS1_k127_5572550_8	158190.SpiGrapes_2332	1.917e-50	181.0	COG5646@1|root,COG5646@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DUF1801
CMS1_k127_5572550_6	158190.SpiGrapes_2333	1.575e-121	403.0	COG2199@1|root,COG3706@2|Bacteria,2J8FW@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,GGDEF,Response_reg
CMS1_k127_5577271_2	1094980.Mpsy_0423	1.166e-44	173.0	COG1216@1|root,arCOG01383@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K12990	ko02024,ko02025,map02024,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2	-	Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2
CMS1_k127_5577271_1	158190.SpiGrapes_0666	2.273e-82	278.0	COG0590@1|root,COG0590@2|Bacteria	2|Bacteria	FJ	tRNA wobble adenosine to inosine editing	guaD	GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	3.5.4.12,3.5.4.3,3.5.4.33	ko:K01487,ko:K01493,ko:K11991	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00429	R01663,R01676,R10223	RC00074,RC00204,RC00477	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
CMS1_k127_5577271_0	158190.SpiGrapes_0665	7.424e-141	447.0	COG0137@1|root,COG0137@2|Bacteria,2J5QQ@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
CMS1_k127_5583987_0	158190.SpiGrapes_0883	2.196e-228	710.0	COG0133@1|root,COG0133@2|Bacteria,2J5J8@203691|Spirochaetes	203691|Spirochaetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS1_k127_5583987_6	877421.AUJT01000037_gene3521	6.495e-95	318.0	COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia,27IBP@186928|unclassified Lachnospiraceae	186801|Clostridia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
CMS1_k127_5583987_3	1121334.KB911070_gene1401	5.06e-207	654.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3WHMI@541000|Ruminococcaceae	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
CMS1_k127_5583987_7	158190.SpiGrapes_0886	3.328e-86	288.0	COG0512@1|root,COG0512@2|Bacteria,2JAAJ@203691|Spirochaetes	203691|Spirochaetes	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS1_k127_5583987_4	158190.SpiGrapes_0887	9.916e-184	580.0	COG0547@1|root,COG0547@2|Bacteria,2J59H@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,Glycos_trans_3N,Glycos_transf_3
CMS1_k127_5583987_5	158190.SpiGrapes_0888	6.411e-101	335.0	COG0134@1|root,COG0134@2|Bacteria,2J5XH@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the	trpF	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
CMS1_k127_5583987_8	158190.SpiGrapes_0889	4.844e-67	235.0	COG0135@1|root,COG0135@2|Bacteria	2|Bacteria	E	phosphoribosylanthranilate isomerase activity	trpF	GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0004640,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48,4.2.1.160,4.2.1.20,5.3.1.24	ko:K01696,ko:K01817,ko:K13498,ko:K22100	ko00260,ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00790,map01100,map01110,map01130,map01230	M00023,M00840	R00674,R02340,R02722,R03508,R03509,R11072	RC00209,RC00210,RC00700,RC00701,RC00944,RC00945,RC02868,RC03343	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.trpF,iPC815.YPO2205,iSBO_1134.SBO_1804,iSDY_1059.SDY_1330	IGPS,PRAI
CMS1_k127_5583987_1	158190.SpiGrapes_0890	1.237e-225	728.0	COG2200@1|root,COG2200@2|Bacteria	2|Bacteria	T	EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GAF,GGDEF,HAMP,MASE3,PAS,PAS_4,PAS_9,Response_reg,dCache_1
CMS1_k127_5583987_2	158190.SpiGrapes_0891	6.236e-214	672.0	COG1114@1|root,COG1114@2|Bacteria,2J6K0@203691|Spirochaetes	203691|Spirochaetes	E	Branched-chain amino acid transport system II carrier protein	brnQ	-	-	ko:K03311	-	-	-	-	ko00000	2.A.26	-	-	Branch_AA_trans
CMS1_k127_5583987_9	158190.SpiGrapes_0895	6.975e-29	117.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_55976_3	158190.SpiGrapes_0850	2.096e-65	224.0	COG3417@1|root,COG3417@2|Bacteria,2J7M5@203691|Spirochaetes	203691|Spirochaetes	M	Peptidoglycan-synthase activator LpoB	-	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
CMS1_k127_55976_0	158190.SpiGrapes_0849	5.333e-118	389.0	2AAUJ@1|root,3107B@2|Bacteria,2J9GC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_55976_2	158190.SpiGrapes_0848	1.076e-85	287.0	2EUFF@1|root,33MXQ@2|Bacteria,2J8XM@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
CMS1_k127_55976_1	158190.SpiGrapes_0846	5.239e-86	288.0	2EUFF@1|root,33MXQ@2|Bacteria,2J8XM@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
CMS1_k127_55976_4	158190.SpiGrapes_0845	5.439e-20	93.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	pspE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
CMS1_k127_5638722_1	318464.IO99_18270	1.402e-59	209.0	COG3708@1|root,COG3708@2|Bacteria,1V3UC@1239|Firmicutes,24IBX@186801|Clostridia,36RI2@31979|Clostridiaceae	186801|Clostridia	K	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cass2
CMS1_k127_5638722_0	158190.SpiGrapes_0100	9.457e-234	731.0	COG1975@1|root,COG1975@2|Bacteria,2JBGH@203691|Spirochaetes	203691|Spirochaetes	O	TIGRFAM Selenium-dependent molybdenum hydroxylase system protein, YqeB family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS1_k127_5683864_0	1262449.CP6013_1449	1.067e-81	278.0	2BUWD@1|root,32Q8G@2|Bacteria,1UHQJ@1239|Firmicutes,24F32@186801|Clostridia,36V1X@31979|Clostridiaceae	186801|Clostridia	S	SatD family (SatD)	-	-	-	-	-	-	-	-	-	-	-	-	SatD
CMS1_k127_5683864_2	994573.T472_0207830	2.386e-64	229.0	COG5061@1|root,COG5061@2|Bacteria,1VF12@1239|Firmicutes,24K4K@186801|Clostridia,36KU6@31979|Clostridiaceae	186801|Clostridia	OU	Protein of unknown function (DUF3307)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3307
CMS1_k127_5683864_4	903814.ELI_4278	1.865e-52	200.0	COG2271@1|root,COG2271@2|Bacteria,1TRPU@1239|Firmicutes,25C8W@186801|Clostridia	186801|Clostridia	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
CMS1_k127_5683864_3	610130.Closa_0065	9.874e-62	219.0	COG0637@1|root,COG0637@2|Bacteria,1UZE0@1239|Firmicutes,24DWR@186801|Clostridia,222R9@1506553|Lachnoclostridium	186801|Clostridia	S	HAD-superfamily hydrolase, subfamily IA, variant 3	pgmB	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_5683864_1	397287.C807_03784	9.26e-77	262.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,27IFR@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
CMS1_k127_569828_5	696281.Desru_1649	2.898e-40	150.0	COG1657@1|root,COG1657@2|Bacteria,1TPY3@1239|Firmicutes,247MQ@186801|Clostridia,2617M@186807|Peptococcaceae	186801|Clostridia	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_569828_4	158190.SpiGrapes_1765	9.536e-41	158.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
CMS1_k127_569828_0	158190.SpiGrapes_1766	5.534e-202	637.0	COG0534@1|root,COG0534@2|Bacteria,2J6H0@203691|Spirochaetes	158190.SpiGrapes_1766|-	V	PFAM multi antimicrobial extrusion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_569828_2	641107.CDLVIII_2009	1.024e-53	195.0	COG1280@1|root,COG1280@2|Bacteria,1TSNA@1239|Firmicutes,24CNE@186801|Clostridia,36JRF@31979|Clostridiaceae	186801|Clostridia	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	ko:K11249	-	-	-	-	ko00000,ko02000	2.A.76.1.4	-	-	LysE
CMS1_k127_569828_3	1232453.BAIF02000066_gene2059	4.579e-50	181.0	COG3177@1|root,COG3177@2|Bacteria,1TZWX@1239|Firmicutes,247MZ@186801|Clostridia	186801|Clostridia	E	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
CMS1_k127_569828_6	411459.RUMOBE_00757	3.037e-07	53.0	COG3177@1|root,COG3177@2|Bacteria,1TZWX@1239|Firmicutes,247MZ@186801|Clostridia,3Y0W4@572511|Blautia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Fic
CMS1_k127_569828_1	522772.Dacet_1134	7.342e-64	220.0	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
CMS1_k127_5707596_5	1246459.KB898366_gene5403	4.083e-22	96.0	COG1879@1|root,COG1879@2|Bacteria,1MUAT@1224|Proteobacteria,2U8J1@28211|Alphaproteobacteria,4BDG6@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
CMS1_k127_5707596_0	1232452.BAIB02000006_gene1403	1.259e-170	550.0	COG1129@1|root,COG1129@2|Bacteria	2|Bacteria	G	ABC transporter	-	-	3.6.3.17	ko:K02056,ko:K10441,ko:K10562	ko02010,map02010	M00212,M00220,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9	-	-	ABC_tran
CMS1_k127_5707596_1	411902.CLOBOL_06154	5.881e-158	509.0	COG0624@1|root,COG0624@2|Bacteria,1TQS9@1239|Firmicutes,24AXQ@186801|Clostridia,21XSU@1506553|Lachnoclostridium	186801|Clostridia	E	Psort location Cytoplasmic, score 8.87	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_5707596_2	1232452.BAIB02000006_gene1401	1.391e-93	317.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K10556	ko02010,ko02024,map02010,map02024	M00212,M00219	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.8	-	-	BPD_transp_2
CMS1_k127_5707596_4	411902.CLOBOL_06152	1.644e-89	306.0	COG1172@1|root,COG1172@2|Bacteria,1VTHK@1239|Firmicutes,24ZAC@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
CMS1_k127_5707596_3	865861.AZSU01000002_gene2812	2.755e-93	312.0	COG5426@1|root,COG5426@2|Bacteria,1TNZD@1239|Firmicutes,24A2A@186801|Clostridia	186801|Clostridia	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
CMS1_k127_5707596_6	1232452.BAIB02000006_gene1404	1.07e-21	97.0	COG1879@1|root,COG1879@2|Bacteria,1TRBC@1239|Firmicutes,24P85@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
CMS1_k127_5746069_0	158190.SpiGrapes_1733	3.013e-217	678.0	COG0683@1|root,COG0683@2|Bacteria,2J62Q@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS1_k127_5746069_2	158190.SpiGrapes_1732	5.552e-165	522.0	COG0559@1|root,COG0559@2|Bacteria,2J64W@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS1_k127_5746069_1	158190.SpiGrapes_1731	5.628e-189	593.0	COG4177@1|root,COG4177@2|Bacteria,2J5N5@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS1_k127_5746069_4	293826.Amet_4116	1.373e-103	342.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,36F00@31979|Clostridiaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
CMS1_k127_5746069_3	158190.SpiGrapes_1729	2.253e-138	443.0	COG0410@1|root,COG0410@2|Bacteria,2J5VQ@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
CMS1_k127_5746069_5	158190.SpiGrapes_1728	2.411e-93	307.0	299ND@1|root,2ZWQQ@2|Bacteria,2J8VN@203691|Spirochaetes	203691|Spirochaetes	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
CMS1_k127_5746069_6	1121121.KB894309_gene1711	3.914e-16	79.0	COG2376@1|root,COG2376@2|Bacteria,1TP92@1239|Firmicutes,4H9VS@91061|Bacilli,26V0N@186822|Paenibacillaceae	91061|Bacilli	G	Dihydroxyacetone kinase	dhaK	-	2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Dak1,Dak2
CMS1_k127_5769240_6	158190.SpiGrapes_2891	3.286e-35	134.0	COG0398@1|root,COG0398@2|Bacteria,2J8MX@203691|Spirochaetes	203691|Spirochaetes	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS1_k127_5769240_2	158190.SpiGrapes_2890	4.031e-118	381.0	COG1183@1|root,COG1183@2|Bacteria,2J8B5@203691|Spirochaetes	203691|Spirochaetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
CMS1_k127_5769240_1	158190.SpiGrapes_2889	8.976e-219	682.0	COG0438@1|root,COG0438@2|Bacteria,2J7E2@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS1_k127_5769240_5	1297617.JPJD01000035_gene650	2.869e-54	201.0	COG0688@1|root,COG0688@2|Bacteria,1TR34@1239|Firmicutes,248VU@186801|Clostridia,26BDC@186813|unclassified Clostridiales	186801|Clostridia	I	Phosphatidylserine decarboxylase	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
CMS1_k127_5769240_4	457412.RSAG_00474	2.006e-84	286.0	COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,3WHS4@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_5769240_0	158190.SpiGrapes_2885	3.427e-261	808.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,HAMP,HATPase_c,HisKA
CMS1_k127_5769240_3	158190.SpiGrapes_2884	6.446e-105	342.0	COG0454@1|root,COG0456@2|Bacteria,2J8N4@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
CMS1_k127_579880_2	621372.ACIH01000050_gene1053	1.234e-58	210.0	COG0395@1|root,COG0395@2|Bacteria,1TPIF@1239|Firmicutes,4HE61@91061|Bacilli,26Q9R@186822|Paenibacillaceae	91061|Bacilli	P	Sugar ABC transporter ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_579880_0	333138.LQ50_08485	1.749e-203	658.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli,1ZPV2@1386|Bacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CMS1_k127_579880_3	158190.SpiGrapes_0270	6.11e-42	156.0	COG4628@1|root,COG4628@2|Bacteria	2|Bacteria	S	conserved protein (DUF2132)	YPO1157	-	-	-	-	-	-	-	-	-	-	-	VF530
CMS1_k127_579880_1	158189.SpiBuddy_2448	2.03e-135	436.0	COG0513@1|root,COG0513@2|Bacteria	2|Bacteria	L	helicase activity	rhlE	-	3.6.4.13,4.2.1.96	ko:K01724,ko:K11927	ko00790,ko03018,map00790,map03018	-	R04734	RC01208	ko00000,ko00001,ko01000,ko03019,ko04147	-	-	-	DEAD,Helicase_C
CMS1_k127_5799213_4	553973.CLOHYLEM_05038	2.533e-18	86.0	COG0524@1|root,COG0524@2|Bacteria,1V33S@1239|Firmicutes,24G11@186801|Clostridia	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS1_k127_5799213_2	573413.Spirs_0772	6.945e-132	424.0	COG1028@1|root,COG1028@2|Bacteria,2J6F7@203691|Spirochaetes	203691|Spirochaetes	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.127,1.1.1.69	ko:K00046,ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
CMS1_k127_5799213_1	1123274.KB899420_gene4032	2.194e-150	480.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	1.1.1.18,1.1.1.369	ko:K00010,ko:K03810	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_5799213_3	573413.Spirs_0774	3.596e-109	360.0	COG1082@1|root,COG1082@2|Bacteria,2JB5S@203691|Spirochaetes	203691|Spirochaetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS1_k127_5799213_0	1123274.KB899420_gene4030	3.943e-161	512.0	COG3181@1|root,COG3181@2|Bacteria,2J7TJ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
CMS1_k127_5801917_4	1125725.HMPREF1325_1367	1.207e-14	74.0	COG0627@1|root,COG0627@2|Bacteria,2J6QR@203691|Spirochaetes	203691|Spirochaetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS1_k127_5801917_3	1125725.HMPREF1325_1368	4.304e-111	364.0	COG0627@1|root,COG0627@2|Bacteria,2J6QR@203691|Spirochaetes	203691|Spirochaetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS1_k127_5801917_1	1125725.HMPREF1325_1369	1.97e-143	461.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS1_k127_5801917_0	1125725.HMPREF1325_1370	4.09e-219	689.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_5801917_2	1125725.HMPREF1325_1371	1.206e-132	427.0	COG1879@1|root,COG1879@2|Bacteria,2J726@203691|Spirochaetes	203691|Spirochaetes	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
CMS1_k127_5808452_7	457421.CBFG_05931	7.088e-17	79.0	COG4948@1|root,COG4948@2|Bacteria,1TUWS@1239|Firmicutes,249BH@186801|Clostridia	186801|Clostridia	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
CMS1_k127_5808452_3	158190.SpiGrapes_1720	1.428e-163	520.0	COG2084@1|root,COG2084@2|Bacteria,2J6T0@203691|Spirochaetes	203691|Spirochaetes	I	PFAM NAD binding domain of 6-phosphogluconate dehydrogenase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
CMS1_k127_5808452_1	158190.SpiGrapes_1719	1.185e-258	800.0	COG4948@1|root,COG4948@2|Bacteria,2J9JE@203691|Spirochaetes	203691|Spirochaetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C
CMS1_k127_5808452_4	158190.SpiGrapes_1718	2.789e-163	518.0	COG0329@1|root,COG0329@2|Bacteria,2J9K2@203691|Spirochaetes	203691|Spirochaetes	H	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS1_k127_5808452_0	158190.SpiGrapes_1714	3.358e-285	881.0	COG2721@1|root,COG2721@2|Bacteria,2J6IB@203691|Spirochaetes	203691|Spirochaetes	G	D-galactarate dehydratase Altronate hydrolase	-	-	4.2.1.42	ko:K01708	ko00053,map00053	-	R05608	RC00543	ko00000,ko00001,ko01000	-	-	-	GD_AH_C,SAF
CMS1_k127_5808452_5	985053.VMUT_1166	1.189e-142	473.0	COG1073@1|root,arCOG01649@2157|Archaea	2157|Archaea	E	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS1_k127_5808452_6	180332.JTGN01000007_gene3843	1.877e-19	95.0	COG1846@1|root,COG1846@2|Bacteria,1VX5R@1239|Firmicutes,24T7U@186801|Clostridia	186801|Clostridia	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
CMS1_k127_5808452_2	158190.SpiGrapes_1689	6.187e-200	625.0	COG1609@1|root,COG1609@2|Bacteria,2JANU@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
CMS1_k127_581269_2	1506994.JNLQ01000002_gene696	8.079e-45	165.0	2DM2C@1|root,31EMM@2|Bacteria,1V8MD@1239|Firmicutes,24JEA@186801|Clostridia,4C12H@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_581269_4	869209.Tresu_0528	1.961e-23	103.0	2E9Z3@1|root,3344K@2|Bacteria,2J8SH@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_581269_0	158189.SpiBuddy_2423	1.816e-115	376.0	COG1349@1|root,COG1349@2|Bacteria,2JAAK@203691|Spirochaetes	203691|Spirochaetes	K	DeoR C terminal sensor domain	-	-	-	ko:K11534	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
CMS1_k127_581269_1	1125725.HMPREF1325_2184	4.182e-80	270.0	COG0346@1|root,COG0346@2|Bacteria,2J7HC@203691|Spirochaetes	203691|Spirochaetes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
CMS1_k127_581269_3	1125725.HMPREF1325_2183	2.462e-40	156.0	COG0794@1|root,COG0794@2|Bacteria,2J8VZ@203691|Spirochaetes	203691|Spirochaetes	G	SIS domain	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
CMS1_k127_581269_5	1125725.HMPREF1325_2182	2.077e-11	66.0	COG1879@1|root,COG1879@2|Bacteria,2J726@203691|Spirochaetes	2|Bacteria	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
CMS1_k127_5814621_0	158190.SpiGrapes_0932	2.69e-190	598.0	COG1609@1|root,COG1609@2|Bacteria,2J6MT@203691|Spirochaetes	203691|Spirochaetes	K	PFAM periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_5814621_1	158190.SpiGrapes_0939	1.088e-90	301.0	COG2103@1|root,COG2103@2|Bacteria,2J5NI@203691|Spirochaetes	203691|Spirochaetes	H	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
CMS1_k127_5824764_18	760011.Spico_0919	1.841e-60	212.0	COG0263@1|root,COG0263@2|Bacteria,2J6GB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
CMS1_k127_5824764_7	158190.SpiGrapes_3188	1.067e-167	530.0	COG1216@1|root,COG1216@2|Bacteria,2J6ET@203691|Spirochaetes	203691|Spirochaetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5824764_14	158190.SpiGrapes_3189	2.508e-110	361.0	COG0860@1|root,COG0860@2|Bacteria,2J5PE@203691|Spirochaetes	203691|Spirochaetes	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1
CMS1_k127_5824764_17	158190.SpiGrapes_3190	6.697e-82	276.0	COG4832@1|root,COG4832@2|Bacteria,2J5MV@203691|Spirochaetes	203691|Spirochaetes	S	conserved protein (DUF2174)	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
CMS1_k127_5824764_1	158190.SpiGrapes_3196	1.507e-277	857.0	COG1488@1|root,COG1488@2|Bacteria,2J5IF@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
CMS1_k127_5824764_2	158190.SpiGrapes_3197	8.533e-259	800.0	COG0172@1|root,COG0172@2|Bacteria,2J5EM@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
CMS1_k127_5824764_12	158190.SpiGrapes_3198	1.169e-128	415.0	COG0345@1|root,COG0345@2|Bacteria,2J6DB@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
CMS1_k127_5824764_16	158190.SpiGrapes_3199	7.394e-93	306.0	COG0219@1|root,COG0219@2|Bacteria,2J95Z@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	-	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
CMS1_k127_5824764_11	158190.SpiGrapes_3206	1.328e-139	447.0	COG1968@1|root,COG1968@2|Bacteria,2J5SC@203691|Spirochaetes	203691|Spirochaetes	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
CMS1_k127_5824764_6	158190.SpiGrapes_3207	2.217e-173	550.0	COG0738@1|root,COG0738@2|Bacteria,2J6KA@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_5824764_0	158190.SpiGrapes_3210	6.637e-285	882.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2J65R@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
CMS1_k127_5824764_10	158190.SpiGrapes_3211	7.156e-157	499.0	COG1013@1|root,COG1013@2|Bacteria,2J6R4@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
CMS1_k127_5824764_4	158190.SpiGrapes_3213	1.355e-213	668.0	COG0389@1|root,COG0389@2|Bacteria,2J5NZ@203691|Spirochaetes	203691|Spirochaetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
CMS1_k127_5824764_8	158190.SpiGrapes_3214	9.567e-164	524.0	COG1181@1|root,COG1181@2|Bacteria,2J611@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS1_k127_5824764_5	158190.SpiGrapes_3215	5.62e-212	670.0	COG0769@1|root,COG0769@2|Bacteria,2J5HR@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS1_k127_5824764_3	1469948.JPNB01000001_gene1107	1.049e-214	672.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,36EU1@31979|Clostridiaceae	186801|Clostridia	C	Dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
CMS1_k127_5824764_15	158190.SpiGrapes_3219	9.84e-106	347.0	2DBAF@1|root,2Z82V@2|Bacteria,2J6F1@203691|Spirochaetes	203691|Spirochaetes	S	CRISPR-associated protein Cas5, N-terminal domain	-	-	-	ko:K19119	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas5d
CMS1_k127_5824764_13	158190.SpiGrapes_3220	8.9e-120	391.0	28HN3@1|root,2Z7WH@2|Bacteria,2J5Z8@203691|Spirochaetes	203691|Spirochaetes	S	CRISPR-associated protein, Csd1 family	-	-	-	ko:K19117	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Csd1
CMS1_k127_5837983_2	158190.SpiGrapes_0193	6.506e-124	403.0	COG3819@1|root,COG3819@2|Bacteria,2J71B@203691|Spirochaetes	203691|Spirochaetes	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF969
CMS1_k127_5837983_1	158190.SpiGrapes_0194	3.893e-172	543.0	COG3817@1|root,COG3817@2|Bacteria,2J71M@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF979)	-	-	-	-	-	-	-	-	-	-	-	-	DUF979
CMS1_k127_5837983_3	158190.SpiGrapes_0195	2.209e-115	374.0	COG2039@1|root,COG2039@2|Bacteria,2J70U@203691|Spirochaetes	203691|Spirochaetes	O	Removes 5-oxoproline from various penultimate amino acid residues except L-proline	pcp	-	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
CMS1_k127_5837983_6	158190.SpiGrapes_0196	2.394e-59	208.0	COG2105@1|root,COG2105@2|Bacteria	2|Bacteria	F	PFAM AIG2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
CMS1_k127_5837983_0	411460.RUMTOR_01562	2.287e-270	845.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3XZ8B@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
CMS1_k127_5837983_5	610130.Closa_1129	7.5e-80	281.0	COG2807@1|root,COG2807@2|Bacteria,1UMDU@1239|Firmicutes,25GFP@186801|Clostridia,221GC@1506553|Lachnoclostridium	186801|Clostridia	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_5837983_4	931626.Awo_c12110	1.245e-103	344.0	COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24HPS@186801|Clostridia,25ZFS@186806|Eubacteriaceae	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS1_k127_5837983_7	384676.PSEEN4321	7.484e-21	94.0	COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,1S6BG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cytotoxic translational repressor of toxin-antitoxin stability system	-	-	-	-	-	-	-	-	-	-	-	-	RelE
CMS1_k127_5888916_2	573413.Spirs_1534	8.953e-81	274.0	COG0061@1|root,COG0061@2|Bacteria,2J5BE@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
CMS1_k127_5888916_0	158190.SpiGrapes_0603	7.083e-274	851.0	COG0497@1|root,COG0497@2|Bacteria,2J5E5@203691|Spirochaetes	203691|Spirochaetes	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
CMS1_k127_5888916_1	158190.SpiGrapes_0602	1.062e-116	383.0	COG1449@1|root,COG1449@2|Bacteria,2J742@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
CMS1_k127_5892540_0	158190.SpiGrapes_0866	2.763e-192	606.0	COG0477@1|root,COG0477@2|Bacteria,2J6CF@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_3
CMS1_k127_5892540_1	158190.SpiGrapes_0867	6.562e-86	288.0	COG1309@1|root,COG1309@2|Bacteria,2J9F4@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_5892540_2	1122212.AULO01000010_gene81	2.251e-16	84.0	COG4637@1|root,COG4637@2|Bacteria,1ND40@1224|Proteobacteria,1RPX7@1236|Gammaproteobacteria,1XMJ6@135619|Oceanospirillales	135619|Oceanospirillales	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
CMS1_k127_5892659_1	1408823.AXUS01000004_gene252	5.44e-43	162.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,25QEJ@186804|Peptostreptococcaceae	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	wtpC	-	3.6.3.29,3.6.3.55	ko:K02017,ko:K15497	ko02010,map02010	M00189,M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5,3.A.1.8	-	-	ABC_tran,TOBE,TOBE_2
CMS1_k127_5892659_0	573413.Spirs_3472	8.094e-84	286.0	COG2014@1|root,COG2014@2|Bacteria	2|Bacteria	F	Putative heavy-metal chelation	-	-	-	ko:K09138	-	-	-	-	ko00000	-	-	-	DUF364
CMS1_k127_5892659_2	1151292.QEW_0844	2.315e-31	127.0	COG2768@1|root,COG2768@2|Bacteria,1UJH4@1239|Firmicutes,25GGG@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_9,Flavodoxin_5
CMS1_k127_5898651_2	158190.SpiGrapes_0142	9.853e-109	354.0	COG1309@1|root,COG1309@2|Bacteria,2J95Q@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_5898651_0	158190.SpiGrapes_0143	2.324e-205	649.0	2E2R6@1|root,32XTS@2|Bacteria,2J5DJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5898651_1	158190.SpiGrapes_0144	2.105e-134	433.0	COG3026@1|root,COG3026@2|Bacteria,2J61M@203691|Spirochaetes	203691|Spirochaetes	T	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS1_k127_5914695_3	889378.Spiaf_0411	1.541e-54	204.0	COG1609@1|root,COG1609@2|Bacteria,2J63Y@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_5914695_0	158190.SpiGrapes_3066	1.319e-290	898.0	COG1070@1|root,COG1070@2|Bacteria,2J62U@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
CMS1_k127_5914695_1	1382315.JPOI01000001_gene2327	1.402e-216	687.0	COG3534@1|root,COG3534@2|Bacteria,1TRY9@1239|Firmicutes,4HAZ7@91061|Bacilli,1WENP@129337|Geobacillus	91061|Bacilli	G	Alpha-L-arabinofuranosidase C-terminus	abfA	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
CMS1_k127_5914695_2	158190.SpiGrapes_3064	1.208e-71	243.0	COG2160@1|root,COG2160@2|Bacteria,2J6CR@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
CMS1_k127_5927241_0	158190.SpiGrapes_1022	3.661e-179	568.0	COG0642@1|root,COG0642@2|Bacteria	2|Bacteria	T	Histidine kinase	chvG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K07642,ko:K14980,ko:K18143	ko01501,ko02020,map01501,map02020	M00450,M00520,M00645,M00646,M00648,M00649,M00655	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
CMS1_k127_5927241_1	1163671.JAGI01000001_gene218	2.675e-62	220.0	COG0622@1|root,COG0622@2|Bacteria,1V1X1@1239|Firmicutes,24GA4@186801|Clostridia,36G0K@31979|Clostridiaceae	186801|Clostridia	S	Phosphoesterase	yfcE	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
CMS1_k127_5928326_4	158190.SpiGrapes_3060	4.583e-40	149.0	COG1609@1|root,COG1609@2|Bacteria,2J7E3@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_4
CMS1_k127_5928326_2	158190.SpiGrapes_3061	8.311e-220	683.0	COG4213@1|root,COG4213@2|Bacteria,2J5TP@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type xylose transport system, periplasmic component	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
CMS1_k127_5928326_0	158190.SpiGrapes_3062	1.718e-308	951.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10441,ko:K10542,ko:K10545,ko:K10548,ko:K17215	ko02010,map02010	M00212,M00214,M00215,M00216,M00221,M00593	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.4,3.A.1.2.5	-	-	ABC_tran
CMS1_k127_5928326_1	158190.SpiGrapes_3063	4.934e-223	694.0	COG4214@1|root,COG4214@2|Bacteria,2J5AE@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
CMS1_k127_5928326_3	158190.SpiGrapes_3064	1.151e-212	663.0	COG2160@1|root,COG2160@2|Bacteria,2J6CR@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
CMS1_k127_5947913_4	158190.SpiGrapes_2302	1.423e-32	126.0	COG0841@1|root,COG0841@2|Bacteria,2J5HW@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS1_k127_5947913_1	158190.SpiGrapes_2301	5.232e-132	428.0	COG0845@1|root,COG0845@2|Bacteria,2J6DV@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mtrC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
CMS1_k127_5947913_0	158190.SpiGrapes_2300	3.202e-199	630.0	COG1538@1|root,COG1538@2|Bacteria,2J5YA@203691|Spirochaetes	203691|Spirochaetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS1_k127_5947913_2	158190.SpiGrapes_2299	4.885e-118	391.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_5947913_3	1122947.FR7_0764	2.969e-54	198.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS1_k127_5947913_5	1226325.HMPREF1548_02533	2.733e-20	94.0	COG2199@1|root,COG2199@2|Bacteria,1UYBY@1239|Firmicutes,248PA@186801|Clostridia,36V8P@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_5950372_6	158190.SpiGrapes_0655	1.681e-49	177.0	COG0360@1|root,COG0360@2|Bacteria,2J88X@203691|Spirochaetes	203691|Spirochaetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
CMS1_k127_5950372_3	158190.SpiGrapes_0654	1.392e-90	299.0	COG0629@1|root,COG0629@2|Bacteria,2J7A3@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS1_k127_5950372_5	158190.SpiGrapes_0653	1.236e-51	183.0	COG0238@1|root,COG0238@2|Bacteria,2J8ZY@203691|Spirochaetes	203691|Spirochaetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
CMS1_k127_5950372_1	158190.SpiGrapes_0652	4.821e-158	503.0	2DZ40@1|root,34CCA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
CMS1_k127_5950372_4	158190.SpiGrapes_0651	1.614e-85	287.0	COG0359@1|root,COG0359@2|Bacteria,2J6J9@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
CMS1_k127_5950372_0	158190.SpiGrapes_0650	1.142e-274	847.0	COG0305@1|root,COG0305@2|Bacteria,2J590@203691|Spirochaetes	203691|Spirochaetes	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
CMS1_k127_5950372_2	760011.Spico_0696	5.748e-96	331.0	COG0750@1|root,COG0750@2|Bacteria,2J616@203691|Spirochaetes	203691|Spirochaetes	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
CMS1_k127_5950372_7	158190.SpiGrapes_0648	3.561e-15	76.0	COG0743@1|root,COG0743@2|Bacteria,2J5M4@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
CMS1_k127_6023121_1	158190.SpiGrapes_3119	4.869e-102	336.0	COG1737@1|root,COG1737@2|Bacteria,2JB8F@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
CMS1_k127_6023121_2	158190.SpiGrapes_3120	3.822e-100	331.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
CMS1_k127_6023121_4	158190.SpiGrapes_3130	1.749e-85	284.0	2CBBS@1|root,33312@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6023121_5	1163671.JAGI01000003_gene634	3.229e-40	153.0	COG1846@1|root,COG1846@2|Bacteria,1VB3Q@1239|Firmicutes,25CPU@186801|Clostridia,36WYX@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS1_k127_6023121_3	404380.Gbem_2523	1.23e-90	307.0	COG2761@1|root,COG2761@2|Bacteria,1QVUQ@1224|Proteobacteria	1224|Proteobacteria	Q	dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_5
CMS1_k127_6023121_0	1117379.BABA_02192	4.526e-137	443.0	COG1741@1|root,COG1741@2|Bacteria,1TQDV@1239|Firmicutes,4HMYE@91061|Bacilli,1ZM90@1386|Bacillus	91061|Bacilli	S	Belongs to the pirin family	-	-	-	-	-	-	-	-	-	-	-	-	Pirin,Pirin_C
CMS1_k127_6029763_1	158190.SpiGrapes_2112	1.372e-179	567.0	COG0624@1|root,COG0624@2|Bacteria,2J743@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Peptidase family M20 M25 M40	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_6029763_5	158190.SpiGrapes_2111	1.865e-67	231.0	COG0071@1|root,COG0071@2|Bacteria,2J88K@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS1_k127_6029763_0	158190.SpiGrapes_2110	2.037e-195	612.0	COG0078@1|root,COG0078@2|Bacteria,2J5RT@203691|Spirochaetes	203691|Spirochaetes	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
CMS1_k127_6029763_3	158190.SpiGrapes_2109	8.112e-155	490.0	COG1464@1|root,COG1464@2|Bacteria,2J5VI@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the nlpA lipoprotein family	blpG	-	-	ko:K02073	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	Lipoprotein_9
CMS1_k127_6029763_4	158190.SpiGrapes_2108	4.741e-118	383.0	COG2011@1|root,COG2011@2|Bacteria,2J67S@203691|Spirochaetes	203691|Spirochaetes	P	D-methionine transport system permease protein MetI	-	-	-	ko:K02072	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	BPD_transp_1
CMS1_k127_6029763_2	158190.SpiGrapes_2107	4.311e-177	559.0	COG1135@1|root,COG1135@2|Bacteria,2J65G@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system	metN	-	-	ko:K02071	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	ABC_tran,NIL
CMS1_k127_6033387_9	158190.SpiGrapes_2028	2.797e-32	126.0	COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS1_k127_6033387_3	158190.SpiGrapes_2027	3.75e-116	377.0	COG0293@1|root,COG0293@2|Bacteria,2J5SK@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
CMS1_k127_6033387_6	158190.SpiGrapes_2026	4.472e-84	284.0	COG0457@1|root,COG0457@2|Bacteria,2J8Y5@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
CMS1_k127_6033387_0	158190.SpiGrapes_2025	2.115e-256	795.0	COG2610@1|root,COG2610@2|Bacteria,2J5W9@203691|Spirochaetes	203691|Spirochaetes	EG	Gluconate	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
CMS1_k127_6033387_4	158190.SpiGrapes_2024	2.431e-114	376.0	COG1237@1|root,COG1237@2|Bacteria,2J831@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS1_k127_6033387_2	158190.SpiGrapes_2023	7.029e-122	396.0	COG2186@1|root,COG2186@2|Bacteria,2J9RW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_6033387_8	158190.SpiGrapes_2022	1.441e-65	228.0	2AIN5@1|root,3194H@2|Bacteria,2J90J@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF3842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3842
CMS1_k127_6033387_1	158190.SpiGrapes_2021	1.488e-168	535.0	COG1121@1|root,COG1121@2|Bacteria,2J7Q1@203691|Spirochaetes	203691|Spirochaetes	P	Domain of unknown function (DUF1893)	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran,TM1506
CMS1_k127_6033387_7	1125725.HMPREF1325_1971	9.727e-72	251.0	COG1108@1|root,COG1108@2|Bacteria,2J88C@203691|Spirochaetes	203691|Spirochaetes	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
CMS1_k127_6033387_5	158190.SpiGrapes_2019	6.488e-98	324.0	COG0803@1|root,COG0803@2|Bacteria,2J8CA@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	-
CMS1_k127_6038181_21	158190.SpiGrapes_0939	8.065e-70	237.0	COG2103@1|root,COG2103@2|Bacteria,2J5NI@203691|Spirochaetes	203691|Spirochaetes	H	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
CMS1_k127_6038181_22	158190.SpiGrapes_0945	9.662e-34	131.0	COG1680@1|root,COG1680@2|Bacteria,2J5Y0@203691|Spirochaetes	203691|Spirochaetes	V	beta-lactamase	bla	-	3.4.16.4	ko:K21469	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,DUF1343
CMS1_k127_6038181_9	158190.SpiGrapes_0946	8.47e-164	518.0	COG0395@1|root,COG0395@2|Bacteria,2J6NP@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
CMS1_k127_6038181_6	158190.SpiGrapes_0947	5.296e-183	574.0	COG4209@1|root,COG4209@2|Bacteria,2J6SZ@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
CMS1_k127_6038181_2	158190.SpiGrapes_0948	1.214e-313	963.0	COG1653@1|root,COG1653@2|Bacteria,2J728@203691|Spirochaetes	203691|Spirochaetes	G	bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
CMS1_k127_6038181_19	158190.SpiGrapes_0950	1.061e-75	258.0	COG3153@1|root,COG3153@2|Bacteria,2J6RA@203691|Spirochaetes	203691|Spirochaetes	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_6038181_4	158190.SpiGrapes_0951	2.015e-229	719.0	COG1472@1|root,COG1472@2|Bacteria,2J7VX@203691|Spirochaetes	203691|Spirochaetes	G	hydrolase, family 3	bglX	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
CMS1_k127_6038181_8	158190.SpiGrapes_0952	5.612e-164	526.0	COG3876@1|root,COG3876@2|Bacteria,2J66X@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
CMS1_k127_6038181_12	158190.SpiGrapes_0954	8.248e-148	474.0	COG1737@1|root,COG1737@2|Bacteria,2J8DG@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix domain, rpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
CMS1_k127_6038181_11	158190.SpiGrapes_0955	1.44e-148	475.0	COG2971@1|root,COG2971@2|Bacteria,2J76M@203691|Spirochaetes	203691|Spirochaetes	G	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
CMS1_k127_6038181_20	158190.SpiGrapes_0956	7.178e-72	245.0	COG2246@1|root,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
CMS1_k127_6038181_0	158189.SpiBuddy_1003	0.0	1159.0	COG3250@1|root,COG3250@2|Bacteria,2J5QC@203691|Spirochaetes	203691|Spirochaetes	G	family 2, TIM barrel	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
CMS1_k127_6038181_14	158189.SpiBuddy_1002	3.356e-136	438.0	COG0395@1|root,COG0395@2|Bacteria,2J65P@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10190	ko02010,map02010	M00199,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.4	-	-	BPD_transp_1
CMS1_k127_6038181_10	158189.SpiBuddy_1001	2.076e-156	496.0	COG1175@1|root,COG1175@2|Bacteria,2J5N6@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10189	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	BPD_transp_1
CMS1_k127_6038181_5	158189.SpiBuddy_1000	5.218e-227	709.0	COG1653@1|root,COG1653@2|Bacteria,2J5ZH@203691|Spirochaetes	203691|Spirochaetes	G	solute-binding protein	-	-	-	ko:K10188	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	SBP_bac_8
CMS1_k127_6038181_13	158189.SpiBuddy_0999	1.94e-139	455.0	COG4585@1|root,COG4585@2|Bacteria,2J7E5@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
CMS1_k127_6038181_16	158189.SpiBuddy_0998	7.026e-110	359.0	COG2197@1|root,COG2197@2|Bacteria,2J7CS@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS1_k127_6038181_17	158190.SpiGrapes_0957	5.858e-102	333.0	COG0386@1|root,COG0386@2|Bacteria,2J73B@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
CMS1_k127_6038181_15	158190.SpiGrapes_0958	6.247e-130	421.0	COG2333@1|root,COG2333@2|Bacteria,2J8WM@203691|Spirochaetes	203691|Spirochaetes	L	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_6038181_3	158190.SpiGrapes_0968	3.14e-248	769.0	COG1171@1|root,COG1171@2|Bacteria,2J6FE@203691|Spirochaetes	203691|Spirochaetes	E	Diaminopropionate ammonia-lyase	dpaL	-	4.3.1.15	ko:K01751	-	-	-	-	ko00000,ko01000	-	-	-	PALP
CMS1_k127_6038181_23	158190.SpiGrapes_0969	2.751e-29	118.0	29B2A@1|root,2ZY11@2|Bacteria,2JBBA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6038181_24	158190.SpiGrapes_0969	4.544e-21	95.0	29B2A@1|root,2ZY11@2|Bacteria,2JBBA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6038181_7	158190.SpiGrapes_0970	3.14e-176	557.0	COG1477@1|root,COG1477@2|Bacteria,2J5JH@203691|Spirochaetes	203691|Spirochaetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
CMS1_k127_6038181_1	158190.SpiGrapes_0971	1.79e-321	989.0	COG1501@1|root,COG1501@2|Bacteria,2J722@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
CMS1_k127_6062875_2	251221.35214912	2.828e-33	132.0	COG5340@1|root,COG5340@2|Bacteria,1GF9X@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator, AbiEi antitoxin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_3,AbiEi_3_N
CMS1_k127_6062875_3	395965.Msil_1976	1.732e-26	113.0	COG2253@1|root,COG2253@2|Bacteria,1MWST@1224|Proteobacteria,2TSSG@28211|Alphaproteobacteria,3NC73@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
CMS1_k127_6062875_0	1105031.HMPREF1141_0565	1.483e-81	284.0	COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,24ARJ@186801|Clostridia,36EHZ@31979|Clostridiaceae	186801|Clostridia	K	PFAM regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	GntR,Peripla_BP_3
CMS1_k127_6062875_6	1232452.BAIB02000003_gene354	4.02e-05	49.0	COG3212@1|root,COG3212@2|Bacteria,1VCWB@1239|Firmicutes,24NZX@186801|Clostridia	186801|Clostridia	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
CMS1_k127_6062875_5	1114856.C496_17922	1.149e-09	72.0	COG1073@1|root,arCOG01649@2157|Archaea,2XW9X@28890|Euryarchaeota,23T03@183963|Halobacteria	183963|Halobacteria	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS1_k127_6062875_4	1121115.AXVN01000036_gene2435	2.268e-11	68.0	COG5421@1|root,COG5421@2|Bacteria,1UHBN@1239|Firmicutes,249CH@186801|Clostridia,3Y11E@572511|Blautia	186801|Clostridia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS1_k127_6062875_1	1042156.CXIVA_11210	1.007e-78	269.0	COG0455@1|root,COG0455@2|Bacteria,1V1FH@1239|Firmicutes,24DP7@186801|Clostridia,36H12@31979|Clostridiaceae	186801|Clostridia	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
CMS1_k127_6086030_5	742733.HMPREF9469_03827	4.529e-05	55.0	COG1073@1|root,COG1073@2|Bacteria,1UQS2@1239|Firmicutes,24F94@186801|Clostridia,2236S@1506553|Lachnoclostridium	186801|Clostridia	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase2,Hydrolase_4,Peptidase_S15
CMS1_k127_6086030_4	1203554.HMPREF1476_02268	4.255e-08	55.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
CMS1_k127_6086030_2	158189.SpiBuddy_2638	6.041e-31	124.0	COG3618@1|root,COG3618@2|Bacteria	2|Bacteria	H	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
CMS1_k127_6086030_3	158189.SpiBuddy_2633	1.297e-16	81.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,2J7WG@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
CMS1_k127_6086030_0	158189.SpiBuddy_2632	1.362e-228	715.0	COG1486@1|root,COG1486@2|Bacteria,2J730@203691|Spirochaetes	203691|Spirochaetes	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
CMS1_k127_6086030_1	760011.Spico_1575	2.491e-35	140.0	COG1609@1|root,COG1609@2|Bacteria,2J7ZD@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_6108019_14	158190.SpiGrapes_2048	3.694e-31	126.0	COG3595@1|root,COG3595@2|Bacteria,2J9CF@203691|Spirochaetes	203691|Spirochaetes	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
CMS1_k127_6108019_4	158190.SpiGrapes_2041	6.893e-204	639.0	COG0505@1|root,COG0505@2|Bacteria,2J5HK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
CMS1_k127_6108019_0	158190.SpiGrapes_2040	0.0	1941.0	COG0458@1|root,COG0458@2|Bacteria,2J6A8@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CMS1_k127_6108019_1	158190.SpiGrapes_2039	0.0	1170.0	COG0173@1|root,COG0173@2|Bacteria,2J5KG@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
CMS1_k127_6108019_7	158190.SpiGrapes_2038	3e-151	481.0	COG0053@1|root,COG0053@2|Bacteria,2J6IT@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
CMS1_k127_6108019_12	158190.SpiGrapes_2037	2.24e-65	224.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	DUF3795,OsmC
CMS1_k127_6108019_8	158190.SpiGrapes_2035	1.181e-126	407.0	28P0Q@1|root,2ZBX8@2|Bacteria,2JATM@203691|Spirochaetes	203691|Spirochaetes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6108019_5	158190.SpiGrapes_2034	3.246e-188	590.0	COG3958@1|root,COG3958@2|Bacteria,2J64Y@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
CMS1_k127_6108019_6	158190.SpiGrapes_2033	2.44e-176	553.0	COG3959@1|root,COG3959@2|Bacteria,2J7TK@203691|Spirochaetes	203691|Spirochaetes	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
CMS1_k127_6108019_9	158190.SpiGrapes_2032	3.01e-113	368.0	COG0235@1|root,COG0235@2|Bacteria,2J6GN@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
CMS1_k127_6108019_2	158190.SpiGrapes_2031	0.0	1082.0	COG0442@1|root,COG0442@2|Bacteria,2J5HF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
CMS1_k127_6108019_10	158190.SpiGrapes_2030	7.967e-97	317.0	COG0666@1|root,COG0666@2|Bacteria,2J63C@203691|Spirochaetes	203691|Spirochaetes	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4
CMS1_k127_6108019_3	158190.SpiGrapes_2029	1.545e-218	682.0	COG1816@1|root,COG1816@2|Bacteria,2J9QW@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Adenosine AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
CMS1_k127_6108019_11	158190.SpiGrapes_2028	5.265e-69	235.0	COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS1_k127_6123077_2	573413.Spirs_3622	7.732e-104	348.0	COG4214@1|root,COG4214@2|Bacteria,2J5AE@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K10544,ko:K10547	ko02010,map02010	M00215,M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4,3.A.1.2.5	-	-	BPD_transp_2
CMS1_k127_6123077_3	545695.TREAZ_2536	5.45e-103	346.0	COG0673@1|root,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_6123077_1	931276.Cspa_c47470	3.792e-121	396.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24A6G@186801|Clostridia,36G1X@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
CMS1_k127_6123077_0	935948.KE386495_gene1296	1.141e-159	510.0	COG0673@1|root,COG0673@2|Bacteria,1TSWE@1239|Firmicutes,24CB6@186801|Clostridia,42I41@68295|Thermoanaerobacterales	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_6133876_24	158190.SpiGrapes_1909	4.858e-108	357.0	COG0477@1|root,COG2814@2|Bacteria,2J9FG@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_6133876_33	158189.SpiBuddy_0012	1.052e-47	180.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03724,ko:K15545	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_20,HTH_24,HTH_5,Helicase_C,ROK
CMS1_k127_6133876_12	158190.SpiGrapes_1911	1.446e-223	695.0	COG0192@1|root,COG0192@2|Bacteria,2J6MD@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CMS1_k127_6133876_26	1232453.BAIF02000066_gene2226	1.765e-80	276.0	COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia	186801|Clostridia	O	anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
CMS1_k127_6133876_2	658659.HMPREF0983_01493	0.0	1224.0	COG0526@1|root,COG1328@1|root,COG0526@2|Bacteria,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,3VP94@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Anaerobic ribonucleoside-triphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone,Glutaredoxin,NRDD
CMS1_k127_6133876_22	158190.SpiGrapes_1914	2.387e-137	439.0	COG1847@1|root,COG1847@2|Bacteria,2J5S0@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
CMS1_k127_6133876_4	158190.SpiGrapes_1915	0.0	1045.0	COG0706@1|root,COG0706@2|Bacteria,2J5HA@203691|Spirochaetes	203691|Spirochaetes	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
CMS1_k127_6133876_29	158190.SpiGrapes_1916	1.181e-62	218.0	COG0594@1|root,COG0594@2|Bacteria	2|Bacteria	J	ribonuclease P activity	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
CMS1_k127_6133876_36	1123072.AUDH01000013_gene1503	3.76e-11	64.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,2UJCE@28211|Alphaproteobacteria,2JUQS@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
CMS1_k127_6133876_37	573413.Spirs_0005	7.956e-08	58.0	COG5512@1|root,COG5512@2|Bacteria,2J8RK@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
CMS1_k127_6133876_16	158190.SpiGrapes_1919	4.462e-207	647.0	COG1195@1|root,COG1195@2|Bacteria,2J5MP@203691|Spirochaetes	203691|Spirochaetes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
CMS1_k127_6133876_15	158190.SpiGrapes_1920	3.677e-218	679.0	COG0592@1|root,COG0592@2|Bacteria,2J629@203691|Spirochaetes	203691|Spirochaetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
CMS1_k127_6133876_6	158190.SpiGrapes_1921	7.794e-282	869.0	COG0593@1|root,COG0593@2|Bacteria,2J5F6@203691|Spirochaetes	203691|Spirochaetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
CMS1_k127_6133876_1	158190.SpiGrapes_1922	0.0	1277.0	COG0187@1|root,COG0187@2|Bacteria,2J67M@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS1_k127_6133876_0	158190.SpiGrapes_1923	0.0	1537.0	COG0188@1|root,COG0188@2|Bacteria,2J5NK@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS1_k127_6133876_34	158190.SpiGrapes_1924	1.433e-39	149.0	COG0694@1|root,COG0694@2|Bacteria,2J8Z4@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0694 Thioredoxin-like protein and domains	-	-	-	-	-	-	-	-	-	-	-	-	NifU
CMS1_k127_6133876_27	373903.Hore_23520	1.39e-77	267.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3WA7J@53433|Halanaerobiales	186801|Clostridia	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS1_k127_6133876_18	158190.SpiGrapes_1926	3.938e-167	529.0	COG1475@1|root,COG1475@2|Bacteria,2J5S6@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS1_k127_6133876_17	158190.SpiGrapes_1927	8.455e-193	602.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,2J58N@203691|Spirochaetes	203691|Spirochaetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,Pro_isomerase
CMS1_k127_6133876_8	158190.SpiGrapes_1928	1.478e-262	812.0	COG1066@1|root,COG1066@2|Bacteria,2J5WN@203691|Spirochaetes	203691|Spirochaetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
CMS1_k127_6133876_14	158190.SpiGrapes_1930	8.456e-221	690.0	COG1916@1|root,COG1916@2|Bacteria,2J5K2@203691|Spirochaetes	203691|Spirochaetes	S	Pheromone shutdown protein	traB	-	-	-	-	-	-	-	-	-	-	-	TraB
CMS1_k127_6133876_20	158190.SpiGrapes_1931	9.099e-148	473.0	COG2431@1|root,COG2431@2|Bacteria,2JAJJ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Membrane protein of	-	-	-	-	-	-	-	-	-	-	-	-	Lys_export
CMS1_k127_6133876_25	158190.SpiGrapes_1933	2.89e-99	329.0	COG1451@1|root,COG1451@2|Bacteria,2J7TY@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
CMS1_k127_6133876_13	158190.SpiGrapes_1934	2.113e-223	696.0	COG0426@1|root,COG0426@2|Bacteria,2J589@203691|Spirochaetes	203691|Spirochaetes	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_5,Lactamase_B
CMS1_k127_6133876_30	158189.SpiBuddy_3046	3.787e-56	206.0	COG2071@1|root,COG2071@2|Bacteria,2J8GR@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
CMS1_k127_6133876_9	158190.SpiGrapes_1936	2.636e-250	779.0	COG2195@1|root,COG2195@2|Bacteria,2J6ZM@203691|Spirochaetes	203691|Spirochaetes	E	aminoacyl-histidine dipeptidase	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_6133876_10	158190.SpiGrapes_1937	2.144e-236	734.0	COG1820@1|root,COG1820@2|Bacteria,2J5F5@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
CMS1_k127_6133876_11	158190.SpiGrapes_1938	3.153e-226	707.0	COG0534@1|root,COG0534@2|Bacteria,2J674@203691|Spirochaetes	203691|Spirochaetes	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_6133876_3	158190.SpiGrapes_1939	0.0	1140.0	COG1032@1|root,COG1032@2|Bacteria,2J5X4@203691|Spirochaetes	203691|Spirochaetes	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
CMS1_k127_6133876_19	158190.SpiGrapes_1940	8.653e-158	503.0	COG1597@1|root,COG1597@2|Bacteria,2J9G6@203691|Spirochaetes	203691|Spirochaetes	I	PFAM Diacylglycerol kinase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS1_k127_6133876_5	158190.SpiGrapes_1941	1.17e-309	949.0	COG3408@1|root,COG3408@2|Bacteria,2J5J1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
CMS1_k127_6133876_21	158190.SpiGrapes_1942	1.982e-140	449.0	COG1076@1|root,COG1076@2|Bacteria,2J9AA@203691|Spirochaetes	203691|Spirochaetes	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
CMS1_k127_6133876_28	1449050.JNLE01000003_gene552	1.515e-64	228.0	COG1102@1|root,COG1102@2|Bacteria,1TRCW@1239|Firmicutes,249Z9@186801|Clostridia,36ENK@31979|Clostridiaceae	186801|Clostridia	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
CMS1_k127_6133876_35	382464.ABSI01000013_gene1575	7.174e-29	134.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
CMS1_k127_6133876_23	158190.SpiGrapes_1943	1.244e-114	370.0	COG0353@1|root,COG0353@2|Bacteria,2J74I@203691|Spirochaetes	203691|Spirochaetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
CMS1_k127_6133876_31	158190.SpiGrapes_1944	1.862e-54	192.0	COG0718@1|root,COG0718@2|Bacteria,2J90U@203691|Spirochaetes	203691|Spirochaetes	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
CMS1_k127_6133876_7	158190.SpiGrapes_1945	1.331e-267	834.0	COG2812@1|root,COG2812@2|Bacteria,2J5A9@203691|Spirochaetes	203691|Spirochaetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
CMS1_k127_6135948_0	1125701.HMPREF1221_01234	2.75e-242	757.0	COG0591@1|root,COG0591@2|Bacteria,2J6EP@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
CMS1_k127_6135948_3	665956.HMPREF1032_01894	2.162e-22	107.0	29V8B@1|root,30GN8@2|Bacteria,1UGBF@1239|Firmicutes,24NX0@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6135948_2	1125701.HMPREF1221_01233	4.433e-120	391.0	COG0363@1|root,COG0363@2|Bacteria,2JAKT@203691|Spirochaetes	203691|Spirochaetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
CMS1_k127_6135948_1	1125701.HMPREF1221_01232	1.545e-136	443.0	COG1609@1|root,COG1609@2|Bacteria,2J8FJ@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_6163829_6	158190.SpiGrapes_1811	4.36e-82	275.0	COG1251@1|root,COG1251@2|Bacteria,2J81W@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
CMS1_k127_6163829_5	158190.SpiGrapes_1810	6.351e-93	304.0	COG1142@1|root,COG1142@2|Bacteria,2J8UZ@203691|Spirochaetes	203691|Spirochaetes	C	Fe-S-cluster-containing hydrogenase	-	-	-	ko:K00196,ko:K05796	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4_11
CMS1_k127_6163829_1	158190.SpiGrapes_1809	2.739e-317	974.0	COG0069@1|root,COG0069@2|Bacteria,2J5WW@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,GATase_2,GXGXG,Glu_syn_central,Glu_synthase
CMS1_k127_6163829_3	158190.SpiGrapes_1808	1.263e-239	742.0	COG0067@1|root,COG0067@2|Bacteria,2J777@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2
CMS1_k127_6163829_0	158190.SpiGrapes_1807	0.0	1311.0	COG3968@1|root,COG3968@2|Bacteria,2J5PV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
CMS1_k127_6163829_4	158190.SpiGrapes_1806	4.182e-155	497.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_6163829_2	158190.SpiGrapes_1805	1.112e-297	927.0	COG3275@1|root,COG3437@1|root,COG3275@2|Bacteria,COG3437@2|Bacteria,2JBG1@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,GGDEF,HD
CMS1_k127_6163829_7	158190.SpiGrapes_1792	1.934e-43	160.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_6167508_1	158190.SpiGrapes_0452	1.564e-87	293.0	COG1564@1|root,COG1564@2|Bacteria,2J7RD@203691|Spirochaetes	203691|Spirochaetes	H	Thiamin pyrophosphokinase, catalytic domain	-	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
CMS1_k127_6167508_0	158190.SpiGrapes_0453	9.749e-122	392.0	COG4198@1|root,COG4198@2|Bacteria,2J5EV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
CMS1_k127_6186990_14	158190.SpiGrapes_0856	2.978e-24	109.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH
CMS1_k127_6186990_1	1507.HMPREF0262_02314	0.0	1091.0	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,36DF0@31979|Clostridiaceae	186801|Clostridia	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
CMS1_k127_6186990_11	1378168.N510_01414	6.639e-31	123.0	COG1918@1|root,COG1918@2|Bacteria,1VEHC@1239|Firmicutes	1239|Firmicutes	P	FeoA domain protein	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
CMS1_k127_6186990_13	1378168.N510_01415	1.883e-24	104.0	COG1918@1|root,COG1918@2|Bacteria,1VEYA@1239|Firmicutes	1239|Firmicutes	P	Fe2 transport system protein A	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
CMS1_k127_6186990_10	158190.SpiGrapes_0854	4.083e-65	224.0	COG1051@1|root,COG1051@2|Bacteria,2J926@203691|Spirochaetes	203691|Spirochaetes	F	TIGRFAM mutator mutT protein	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
CMS1_k127_6186990_0	158190.SpiGrapes_0853	0.0	1564.0	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria	2|Bacteria	L	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,PLDc_2,ResIII
CMS1_k127_6186990_9	573413.Spirs_1241	4.196e-125	413.0	COG1940@1|root,COG1940@2|Bacteria,2J8MA@203691|Spirochaetes	203691|Spirochaetes	GK	ROK family	xylR-1	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
CMS1_k127_6186990_6	1123274.KB899417_gene2108	5.844e-165	525.0	COG1879@1|root,COG1879@2|Bacteria,2J5Z1@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10540	ko02010,ko02030,map02010,map02030	M00214	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.3	-	-	Peripla_BP_4
CMS1_k127_6186990_3	1123274.KB899417_gene2107	5.722e-229	717.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	mglA	-	3.6.3.17	ko:K02056,ko:K10542	ko02010,map02010	M00214,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.3	-	-	ABC_tran
CMS1_k127_6186990_7	1123274.KB899417_gene2106	1.203e-164	523.0	COG4211@1|root,COG4211@2|Bacteria,2J6DI@203691|Spirochaetes	203691|Spirochaetes	G	transport system permease	mglC	-	-	ko:K10541	ko02010,map02010	M00214	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.3	-	-	BPD_transp_2
CMS1_k127_6186990_8	573413.Spirs_1237	2.361e-164	522.0	COG2017@1|root,COG2017@2|Bacteria,2JAQS@203691|Spirochaetes	203691|Spirochaetes	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
CMS1_k127_6186990_2	573413.Spirs_1236	8.145e-241	749.0	COG1486@1|root,COG1486@2|Bacteria,2J6Z5@203691|Spirochaetes	203691|Spirochaetes	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
CMS1_k127_6186990_4	573413.Spirs_1235	1.985e-210	660.0	COG1486@1|root,COG1486@2|Bacteria,2J688@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
CMS1_k127_6186990_5	158190.SpiGrapes_0851	1.613e-199	629.0	COG3014@1|root,COG3014@2|Bacteria,2J7CY@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	-
CMS1_k127_6186990_12	158190.SpiGrapes_0850	8.367e-30	119.0	COG3417@1|root,COG3417@2|Bacteria,2J7M5@203691|Spirochaetes	203691|Spirochaetes	M	Peptidoglycan-synthase activator LpoB	-	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
CMS1_k127_6189526_6	158190.SpiGrapes_0461	1.365e-54	198.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	LRR_5,PT-HINT,SpvB
CMS1_k127_6189526_2	158190.SpiGrapes_0462	1.189e-158	504.0	COG0552@1|root,COG0552@2|Bacteria,2J5KQ@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
CMS1_k127_6189526_1	158190.SpiGrapes_0464	3.38e-201	630.0	COG1186@1|root,COG1186@2|Bacteria,2J5QR@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS1_k127_6189526_0	158190.SpiGrapes_0465	0.0	1124.0	COG1449@1|root,COG1449@2|Bacteria,2J5C8@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
CMS1_k127_6189526_3	158190.SpiGrapes_0466	2.102e-156	495.0	COG2878@1|root,COG2878@2|Bacteria,2J5VT@203691|Spirochaetes	203691|Spirochaetes	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_9
CMS1_k127_6189526_5	158190.SpiGrapes_0467	3.497e-110	358.0	COG4657@1|root,COG4657@2|Bacteria,2J5ES@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS1_k127_6189526_7	158190.SpiGrapes_0468	6.522e-20	88.0	COG4660@1|root,COG4660@2|Bacteria,2J58U@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rsxE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS1_k127_6206224_0	158190.SpiGrapes_0107	6.407e-276	851.0	COG0282@1|root,COG0282@2|Bacteria,2J57M@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
CMS1_k127_6206224_1	158190.SpiGrapes_0106	2.221e-175	552.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
CMS1_k127_6206224_4	158190.SpiGrapes_0105	1.007e-55	198.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	nfeD	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
CMS1_k127_6206224_3	158190.SpiGrapes_0104	3.141e-112	365.0	COG0745@1|root,COG0745@2|Bacteria,2J88Y@203691|Spirochaetes	203691|Spirochaetes	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ompR	-	-	ko:K07657,ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_6206224_2	158190.SpiGrapes_0103	2.628e-139	451.0	COG5002@1|root,COG5002@2|Bacteria,2J6AJ@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,sCache_like
CMS1_k127_62095_28	742738.HMPREF9460_03472	1.661e-57	207.0	COG1802@1|root,COG1802@2|Bacteria,1VIGJ@1239|Firmicutes,24P2P@186801|Clostridia,26C67@186813|unclassified Clostridiales	186801|Clostridia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_62095_11	158190.SpiGrapes_2286	1.562e-199	628.0	COG0025@1|root,COG0025@2|Bacteria,2J9JZ@203691|Spirochaetes	203691|Spirochaetes	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
CMS1_k127_62095_25	158190.SpiGrapes_2285	2.63e-82	280.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
CMS1_k127_62095_10	158190.SpiGrapes_2271	4.832e-219	684.0	COG2223@1|root,COG2223@2|Bacteria,2J78Y@203691|Spirochaetes	203691|Spirochaetes	P	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_62095_19	158190.SpiGrapes_2270	9.906e-120	388.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
CMS1_k127_62095_8	158190.SpiGrapes_2269	5.029e-223	697.0	COG0564@1|root,COG0564@2|Bacteria,2J6JK@203691|Spirochaetes	203691|Spirochaetes	J	PFAM RNA pseudouridylate synthase	-	-	5.4.99.28,5.4.99.29	ko:K06177	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
CMS1_k127_62095_31	1120968.AUBX01000017_gene1933	5.834e-44	181.0	COG3250@1|root,COG3250@2|Bacteria,4NGZH@976|Bacteroidetes,47M3M@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106,Glyco_hydro_2_N
CMS1_k127_62095_18	754027.HMPREF9554_01247	3.548e-120	397.0	COG0626@1|root,COG0626@2|Bacteria,2JBHG@203691|Spirochaetes	203691|Spirochaetes	E	cystathionine	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
CMS1_k127_62095_12	1321815.HMPREF9193_02127	1.47e-189	600.0	COG3669@1|root,COG3669@2|Bacteria,2J69G@203691|Spirochaetes	203691|Spirochaetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
CMS1_k127_62095_29	1321815.HMPREF9193_02126	6.568e-56	205.0	COG2186@1|root,COG2186@2|Bacteria	2|Bacteria	K	Transcriptional regulator	XK27_03105	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_62095_16	1321815.HMPREF9193_02125	6.874e-136	436.0	COG0395@1|root,COG0395@2|Bacteria,2J6V7@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_62095_15	1321815.HMPREF9193_02124	2.821e-141	456.0	COG1175@1|root,COG1175@2|Bacteria,2J5EA@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1175 ABC-type sugar transport systems permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_62095_4	1321815.HMPREF9193_02123	4.823e-233	726.0	COG1653@1|root,COG1653@2|Bacteria,2J6S7@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
CMS1_k127_62095_20	1105031.HMPREF1141_2146	1.061e-112	370.0	COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,36E0S@31979|Clostridiaceae	186801|Clostridia	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
CMS1_k127_62095_23	1007103.AFHW01000144_gene1343	1.915e-86	295.0	COG2145@1|root,COG2145@2|Bacteria,1V1R6@1239|Firmicutes,4HFTJ@91061|Bacilli,26RF9@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	thiM	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008972,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HK
CMS1_k127_62095_21	1174504.AJTN02000037_gene2325	1.326e-110	373.0	COG1457@1|root,COG1457@2|Bacteria,1TTBN@1239|Firmicutes,4HA3B@91061|Bacilli,1ZHPY@1386|Bacillus	91061|Bacilli	F	Permease for cytosine/purines, uracil, thiamine, allantoin	thiP	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
CMS1_k127_62095_27	1196322.A370_01928	1.92e-68	239.0	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,36I8K@31979|Clostridiaceae	186801|Clostridia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
CMS1_k127_62095_1	158190.SpiGrapes_2268	4.024e-265	827.0	COG2199@1|root,COG2199@2|Bacteria,2JBGZ@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_62095_14	158190.SpiGrapes_2267	5.883e-145	466.0	COG3588@1|root,COG3588@2|Bacteria,2J75R@203691|Spirochaetes	203691|Spirochaetes	G	fructose-bisphosphate aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
CMS1_k127_62095_26	158190.SpiGrapes_2266	8.162e-75	257.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	yisX	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
CMS1_k127_62095_22	243275.TDE_0817	4.728e-93	316.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR5	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,DUF1376,HATPase_c_4,HTH_11,HTH_24,HTH_5
CMS1_k127_62095_33	642492.Clole_3993	1.204e-37	146.0	COG3603@1|root,COG3603@2|Bacteria,1V9Y8@1239|Firmicutes,24JKN@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	ko:K09707	-	-	-	-	ko00000	-	-	-	ACT_7
CMS1_k127_62095_24	158190.SpiGrapes_2264	7.048e-83	279.0	COG0515@1|root,COG0515@2|Bacteria	158190.SpiGrapes_2264|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_62095_3	158190.SpiGrapes_2263	7.282e-234	728.0	COG2199@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria	2|Bacteria	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
CMS1_k127_62095_6	158190.SpiGrapes_2262	1.142e-229	715.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gumH	-	2.4.1.252	ko:K13657	-	-	R09733	RC00005,RC00049	ko00000,ko01000,ko01003	-	GT4	-	Glyco_tran_WecB,Glyco_transf_4,Glycos_transf_1
CMS1_k127_62095_34	1121406.JAEX01000018_gene2811	4.588e-36	152.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,42WA6@68525|delta/epsilon subdivisions,2WRYV@28221|Deltaproteobacteria,2MD0F@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,SPASM
CMS1_k127_62095_7	158190.SpiGrapes_2260	2.526e-224	698.0	COG0438@1|root,COG0438@2|Bacteria,2J599@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS1_k127_62095_9	158190.SpiGrapes_2259	3.943e-221	692.0	COG2148@1|root,COG2148@2|Bacteria,2J5VF@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS1_k127_62095_17	158190.SpiGrapes_2258	1.07e-129	417.0	COG1922@1|root,COG1922@2|Bacteria	2|Bacteria	M	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity	gumM	-	2.4.1.187,2.4.1.252	ko:K05946,ko:K13657,ko:K13660	ko05111,map05111	-	R09733	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003	-	GT26,GT4	-	Bac_transf,Glyco_tran_WecB
CMS1_k127_62095_2	158190.SpiGrapes_2257	4.441e-248	771.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
CMS1_k127_62095_13	158190.SpiGrapes_2256	6.041e-184	580.0	2CCWM@1|root,338WR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_62095_32	240016.ABIZ01000001_gene5357	2.297e-43	170.0	COG1216@1|root,COG1216@2|Bacteria,46XEI@74201|Verrucomicrobia,2IVPA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_62095_5	158190.SpiGrapes_2254	1.255e-231	720.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4983,FIVAR,Hemopexin,Laminin_G_3,PA14,Phosphodiest
CMS1_k127_62095_30	158190.SpiGrapes_2253	1.312e-55	196.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	rsbV	-	-	ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
CMS1_k127_62095_0	158190.SpiGrapes_2252	0.0	1216.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179,ko:K13735,ko:K21449	ko00500,ko01100,ko05100,map00500,map01100,map05100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko02000	1.B.40.2	GH5,GH9	-	CHU_C,DUF11,F5_F8_type_C,Gram_pos_anchor,SdrD_B
CMS1_k127_6228374_14	158190.SpiGrapes_2140	1.939e-90	298.0	COG0092@1|root,COG0092@2|Bacteria,2J5AK@203691|Spirochaetes	203691|Spirochaetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
CMS1_k127_6228374_18	158190.SpiGrapes_2139	1.089e-66	229.0	COG0091@1|root,COG0091@2|Bacteria,2J7KV@203691|Spirochaetes	203691|Spirochaetes	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
CMS1_k127_6228374_22	158190.SpiGrapes_2138	8.766e-52	183.0	COG0185@1|root,COG0185@2|Bacteria,2J8DX@203691|Spirochaetes	203691|Spirochaetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
CMS1_k127_6228374_5	158190.SpiGrapes_2137	3.588e-172	541.0	COG0090@1|root,COG0090@2|Bacteria,2J5G3@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
CMS1_k127_6228374_21	158190.SpiGrapes_2136	1.068e-54	192.0	COG0089@1|root,COG0089@2|Bacteria,2J85B@203691|Spirochaetes	203691|Spirochaetes	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
CMS1_k127_6228374_9	158190.SpiGrapes_2135	7.914e-121	391.0	COG0088@1|root,COG0088@2|Bacteria,2J5NS@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
CMS1_k127_6228374_7	158190.SpiGrapes_2134	6.729e-126	403.0	COG0087@1|root,COG0087@2|Bacteria,2J633@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
CMS1_k127_6228374_20	158190.SpiGrapes_2133	3.976e-57	199.0	COG0051@1|root,COG0051@2|Bacteria,2J7XK@203691|Spirochaetes	203691|Spirochaetes	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
CMS1_k127_6228374_4	158190.SpiGrapes_2132	1.901e-257	794.0	COG0050@1|root,COG0050@2|Bacteria,2J5PY@203691|Spirochaetes	203691|Spirochaetes	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CMS1_k127_6228374_13	158190.SpiGrapes_2131	1.412e-91	301.0	COG0049@1|root,COG0049@2|Bacteria,2J7TX@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
CMS1_k127_6228374_16	158190.SpiGrapes_2130	3.468e-73	247.0	COG0048@1|root,COG0048@2|Bacteria,2J7NE@203691|Spirochaetes	203691|Spirochaetes	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
CMS1_k127_6228374_0	158190.SpiGrapes_2129	0.0	2747.0	COG0086@1|root,COG0086@2|Bacteria,2J5S7@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CMS1_k127_6228374_1	158190.SpiGrapes_2128	0.0	2305.0	COG0085@1|root,COG0085@2|Bacteria,2J5JV@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS1_k127_6228374_19	158189.SpiBuddy_2858	5.494e-61	212.0	COG0222@1|root,COG0222@2|Bacteria,2J7NX@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
CMS1_k127_6228374_12	158190.SpiGrapes_2126	1.644e-93	308.0	COG0244@1|root,COG0244@2|Bacteria,2J74F@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
CMS1_k127_6228374_6	158190.SpiGrapes_2125	2.317e-128	412.0	COG0081@1|root,COG0081@2|Bacteria,2J5HN@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
CMS1_k127_6228374_15	158190.SpiGrapes_2124	1.024e-81	274.0	COG0080@1|root,COG0080@2|Bacteria,2J7BU@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
CMS1_k127_6228374_11	158190.SpiGrapes_2123	3.156e-117	377.0	COG0250@1|root,COG0250@2|Bacteria,2J7FV@203691|Spirochaetes	203691|Spirochaetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
CMS1_k127_6228374_26	158190.SpiGrapes_2122	1.832e-23	100.0	COG0690@1|root,COG0690@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
CMS1_k127_6228374_24	158190.SpiGrapes_2120	1.216e-30	122.0	COG0267@1|root,COG0267@2|Bacteria,2J8UW@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
CMS1_k127_6228374_27	1417230.AYOT01000223_gene733	1.569e-05	47.0	COG0267@1|root,COG0267@2|Bacteria,2J8UW@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
CMS1_k127_6228374_2	158190.SpiGrapes_2118	0.0	1585.0	COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes	203691|Spirochaetes	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CMS1_k127_6228374_10	158190.SpiGrapes_2116	1.715e-120	390.0	COG1811@1|root,COG1811@2|Bacteria,2J7KZ@203691|Spirochaetes	203691|Spirochaetes	S	Na channel or pump	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
CMS1_k127_6228374_17	158190.SpiGrapes_2115	9.258e-70	241.0	COG2068@1|root,COG2068@2|Bacteria,2JAZY@203691|Spirochaetes	203691|Spirochaetes	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS1_k127_6228374_3	158190.SpiGrapes_2114	0.0	1484.0	COG0542@1|root,COG0542@2|Bacteria,2J57C@203691|Spirochaetes	203691|Spirochaetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CMS1_k127_6228374_8	158190.SpiGrapes_2113	2.159e-122	393.0	COG1309@1|root,COG1309@2|Bacteria,2J7BQ@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_6228374_25	158190.SpiGrapes_2112	3.952e-25	113.0	COG0624@1|root,COG0624@2|Bacteria,2J743@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Peptidase family M20 M25 M40	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_6245653_1	158190.SpiGrapes_0365	1.936e-117	378.0	COG0024@1|root,COG0024@2|Bacteria,2J5Z7@203691|Spirochaetes	203691|Spirochaetes	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CMS1_k127_6245653_0	158190.SpiGrapes_0366	1.577e-124	399.0	COG2236@1|root,COG2236@2|Bacteria,2J5KF@203691|Spirochaetes	203691|Spirochaetes	F	phosphoribosyl transferase	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
CMS1_k127_6245653_2	1123075.AUDP01000001_gene2348	1.197e-64	227.0	COG0398@1|root,COG0398@2|Bacteria,1V7NH@1239|Firmicutes,24HNU@186801|Clostridia,3WMK9@541000|Ruminococcaceae	186801|Clostridia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS1_k127_6271371_1	158190.SpiGrapes_3019	9.085e-110	357.0	COG1825@1|root,COG1825@2|Bacteria,2J75H@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
CMS1_k127_6271371_2	158190.SpiGrapes_3020	1.322e-99	327.0	COG0193@1|root,COG0193@2|Bacteria,2JAEH@203691|Spirochaetes	203691|Spirochaetes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	-	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
CMS1_k127_6271371_3	573413.Spirs_1816	1.276e-46	186.0	COG0037@1|root,COG0037@2|Bacteria,2J638@203691|Spirochaetes	203691|Spirochaetes	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
CMS1_k127_6271371_0	158190.SpiGrapes_3022	0.0	1124.0	COG0465@1|root,COG0465@2|Bacteria,2J58Y@203691|Spirochaetes	203691|Spirochaetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
CMS1_k127_6272845_3	1246459.KB898366_gene5403	4.083e-22	96.0	COG1879@1|root,COG1879@2|Bacteria,1MUAT@1224|Proteobacteria,2U8J1@28211|Alphaproteobacteria,4BDG6@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
CMS1_k127_6272845_0	1122925.KB895401_gene98	1.059e-153	497.0	COG0624@1|root,COG0624@2|Bacteria,1TQS9@1239|Firmicutes,4HDHW@91061|Bacilli,26UDI@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase family M20/M25/M40	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
CMS1_k127_6272845_1	1499683.CCFF01000017_gene1443	1.028e-85	297.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,24BEY@186801|Clostridia,36J2T@31979|Clostridiaceae	186801|Clostridia	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_6272845_2	760011.Spico_1255	2.16e-68	240.0	COG0524@1|root,COG0524@2|Bacteria,2J6EF@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
CMS1_k127_640323_4	158190.SpiGrapes_0402	2.675e-06	49.0	COG0125@1|root,COG0125@2|Bacteria,2J765@203691|Spirochaetes	203691|Spirochaetes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CMS1_k127_640323_3	246201.SM12261_0257	2.2e-76	268.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,4H9PT@91061|Bacilli,2TNSU@28037|Streptococcus mitis	91061|Bacilli	H	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
CMS1_k127_640323_0	158190.SpiGrapes_0400	8.201e-213	662.0	COG2255@1|root,COG2255@2|Bacteria,2J5IU@203691|Spirochaetes	203691|Spirochaetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
CMS1_k127_640323_1	158190.SpiGrapes_0399	6.35e-95	316.0	COG0632@1|root,COG0632@2|Bacteria,2J6FC@203691|Spirochaetes	203691|Spirochaetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
CMS1_k127_640323_2	158190.SpiGrapes_0398	4.938e-78	262.0	COG0817@1|root,COG0817@2|Bacteria,2J754@203691|Spirochaetes	203691|Spirochaetes	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
CMS1_k127_684540_13	158190.SpiGrapes_0125	2.825e-33	129.0	COG0828@1|root,COG0828@2|Bacteria,2J8QT@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
CMS1_k127_684540_2	158190.SpiGrapes_0124	0.0	1334.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS1_k127_684540_6	158190.SpiGrapes_0123	5.55e-137	440.0	COG1381@1|root,COG1381@2|Bacteria,2J65J@203691|Spirochaetes	203691|Spirochaetes	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
CMS1_k127_684540_4	158190.SpiGrapes_0122	1.347e-188	601.0	28I3N@1|root,2Z87C@2|Bacteria,2J7UN@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
CMS1_k127_684540_12	158189.SpiBuddy_1647	4.197e-35	141.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
CMS1_k127_684540_3	158190.SpiGrapes_0120	4.642e-189	592.0	COG0549@1|root,COG0549@2|Bacteria,2J64E@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the carbamate kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS1_k127_684540_1	158190.SpiGrapes_0119	0.0	1512.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS1_k127_684540_10	33035.JPJF01000049_gene667	4.846e-91	314.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,3XYM5@572511|Blautia	186801|Clostridia	O	Psort location Cytoplasmic, score 8.87	yhbU_1	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
CMS1_k127_684540_5	158190.SpiGrapes_0116	1.249e-144	467.0	COG1215@1|root,COG1215@2|Bacteria,2J664@203691|Spirochaetes	203691|Spirochaetes	M	family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CMS1_k127_684540_14	158190.SpiGrapes_0115	6.943e-25	104.0	2EGU5@1|root,33AKB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_684540_0	158190.SpiGrapes_0113	0.0	1620.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CMS1_k127_684540_9	158190.SpiGrapes_0112	5.438e-101	330.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
CMS1_k127_684540_8	158190.SpiGrapes_0111	1.07e-102	334.0	COG1595@1|root,COG1595@2|Bacteria,2J64C@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_684540_7	158190.SpiGrapes_0110	8.707e-118	381.0	COG0215@1|root,COG0215@2|Bacteria,2J618@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
CMS1_k127_689607_4	33035.JPJF01000019_gene4233	1.009e-31	130.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AHK@186801|Clostridia,3XZH7@572511|Blautia	186801|Clostridia	G	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_689607_0	33035.JPJF01000019_gene4232	1.943e-133	438.0	COG1653@1|root,COG1653@2|Bacteria,1UUUW@1239|Firmicutes,24I2Q@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
CMS1_k127_689607_1	33035.JPJF01000019_gene4237	3.783e-95	321.0	COG1082@1|root,COG1082@2|Bacteria,1UCHD@1239|Firmicutes,24IEY@186801|Clostridia	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
CMS1_k127_689607_5	158189.SpiBuddy_1039	4.342e-05	49.0	COG1178@1|root,COG1178@2|Bacteria,2J6G7@203691|Spirochaetes	2|Bacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
CMS1_k127_689607_2	1235799.C818_01592	4.036e-92	309.0	28JTN@1|root,2Z9IV@2|Bacteria,1V2P2@1239|Firmicutes,24GDH@186801|Clostridia,27MT6@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_689607_3	1235796.C815_01484	1.287e-56	206.0	COG1846@1|root,COG1846@2|Bacteria,1TSQ4@1239|Firmicutes	1239|Firmicutes	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS1_k127_696825_4	1125725.HMPREF1325_2660	2.006e-112	369.0	COG3623@1|root,COG3623@2|Bacteria,2J73T@203691|Spirochaetes	203691|Spirochaetes	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
CMS1_k127_696825_1	1125725.HMPREF1325_2661	3.561e-216	681.0	COG1070@1|root,COG1070@2|Bacteria,2J5DG@203691|Spirochaetes	203691|Spirochaetes	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.53	ko:K00880	ko00040,ko00053,map00040,map00053	-	R01901,R07127	RC00002,RC00017,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_696825_2	1125725.HMPREF1325_2662	8.453e-161	512.0	COG1879@1|root,COG1879@2|Bacteria,2J7Q9@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
CMS1_k127_696825_5	1118054.CAGW01000017_gene4347	2.233e-76	267.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26R5U@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
CMS1_k127_696825_3	1125725.HMPREF1325_2665	3.651e-157	501.0	COG1172@1|root,COG1172@2|Bacteria,2J7VK@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
CMS1_k127_696825_0	1125725.HMPREF1325_2666	2.343e-230	722.0	COG1129@1|root,COG1129@2|Bacteria,2J5C4@203691|Spirochaetes	203691|Spirochaetes	P	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
CMS1_k127_703552_2	1219084.AP014508_gene974	6.203e-109	361.0	COG1840@1|root,COG1840@2|Bacteria,2GCFT@200918|Thermotogae	200918|Thermotogae	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
CMS1_k127_703552_0	158189.SpiBuddy_1625	3.502e-162	527.0	COG1178@1|root,COG1178@2|Bacteria,2J7A4@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
CMS1_k127_703552_1	1391647.AVSV01000017_gene671	5.551e-113	375.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36EAA@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
CMS1_k127_703552_3	573413.Spirs_3871	1.336e-87	299.0	COG0524@1|root,COG0524@2|Bacteria,2JA75@203691|Spirochaetes	203691|Spirochaetes	G	COGs COG0524 Sugar kinase ribokinase family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS1_k127_710949_27	158190.SpiGrapes_2664	1.244e-08	55.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,2J66J@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
CMS1_k127_710949_19	158190.SpiGrapes_2665	2.139e-72	247.0	COG0071@1|root,COG0071@2|Bacteria,2J88K@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K06335,ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
CMS1_k127_710949_24	158190.SpiGrapes_2666	4.642e-55	194.0	COG1917@1|root,COG1917@2|Bacteria,2JBGP@203691|Spirochaetes	203691|Spirochaetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS1_k127_710949_6	158190.SpiGrapes_2667	6.588e-171	539.0	COG0543@1|root,COG0543@2|Bacteria,2J5SH@203691|Spirochaetes	203691|Spirochaetes	C	Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
CMS1_k127_710949_0	158190.SpiGrapes_2668	1.248e-292	901.0	COG0493@1|root,COG0493@2|Bacteria,2J5FP@203691|Spirochaetes	203691|Spirochaetes	C	glutamate synthase (NADPH), homotetrameric	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
CMS1_k127_710949_15	158190.SpiGrapes_2669	3.607e-86	287.0	COG1762@1|root,COG1762@2|Bacteria,2JAXN@203691|Spirochaetes	203691|Spirochaetes	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
CMS1_k127_710949_18	158190.SpiGrapes_2670	3.345e-80	272.0	COG0212@1|root,COG0212@2|Bacteria	2|Bacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298	5-FTHF_cyc-lig
CMS1_k127_710949_31	518637.EUBIFOR_00933	0.0004218	51.0	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,3VNXY@526524|Erysipelotrichia	526524|Erysipelotrichia	P	cobalt transport	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
CMS1_k127_710949_10	158190.SpiGrapes_2672	3.14e-123	401.0	COG1122@1|root,COG1122@2|Bacteria,2J5XT@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter, ATP-binding protein	-	-	-	ko:K16784	ko02010,map02010	M00581	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25.1	-	-	ABC_tran
CMS1_k127_710949_30	1008457.BAEX01000078_gene3055	0.0002962	43.0	2DR32@1|root,339YJ@2|Bacteria,4NYM3@976|Bacteroidetes,1I6CH@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_710949_22	579405.Dd703_3113	7.271e-63	225.0	COG2227@1|root,COG2227@2|Bacteria,1QYHT@1224|Proteobacteria,1T3QK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS1_k127_710949_26	999413.HMPREF1094_04476	3.614e-28	121.0	COG0558@1|root,COG0558@2|Bacteria,1V93Y@1239|Firmicutes,3VSJE@526524|Erysipelotrichia	526524|Erysipelotrichia	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
CMS1_k127_710949_28	760011.Spico_1440	5.33e-08	54.0	COG1196@1|root,COG1196@2|Bacteria,2J8XN@203691|Spirochaetes	203691|Spirochaetes	D	Phage minor structural protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_710949_29	760011.Spico_1166	2.375e-06	54.0	COG1196@1|root,COG1196@2|Bacteria,2J8XN@203691|Spirochaetes	203691|Spirochaetes	D	Phage minor structural protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_710949_21	158189.SpiBuddy_0059	2.377e-64	231.0	COG2186@1|root,COG2186@2|Bacteria,2JASM@203691|Spirochaetes	203691|Spirochaetes	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_710949_25	1163671.JAGI01000001_gene298	1.881e-29	132.0	COG1653@1|root,COG1653@2|Bacteria,1TQJE@1239|Firmicutes,2496C@186801|Clostridia,36FES@31979|Clostridiaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_710949_20	1232453.BAIF02000079_gene25	7.55e-69	245.0	COG1175@1|root,COG1175@2|Bacteria,1TQX5@1239|Firmicutes,24B1Z@186801|Clostridia	186801|Clostridia	P	abc transporter permease protein	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_710949_23	324057.Pjdr2_3677	8.675e-59	215.0	COG0395@1|root,COG0395@2|Bacteria,1TVJU@1239|Firmicutes,4I38F@91061|Bacilli,26UFS@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_710949_5	1121335.Clst_0253	2.201e-174	567.0	COG3533@1|root,COG3533@2|Bacteria,1TNYA@1239|Firmicutes,24841@186801|Clostridia,3WMFB@541000|Ruminococcaceae	186801|Clostridia	S	protein conserved in bacteria	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
CMS1_k127_710949_2	390874.Tpet_1682	4.113e-189	621.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
CMS1_k127_710949_17	891968.Anamo_2035	1.508e-81	278.0	COG1794@1|root,COG1794@2|Bacteria	2|Bacteria	M	racemase activity, acting on amino acids and derivatives	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS14520	Asp_Glu_race
CMS1_k127_710949_13	469618.FVAG_00046	2.995e-95	318.0	COG3246@1|root,COG3246@2|Bacteria,37BEJ@32066|Fusobacteria	32066|Fusobacteria	S	Pfam:Kce	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
CMS1_k127_710949_9	903814.ELI_1578	1.376e-150	489.0	COG3395@1|root,COG3395@2|Bacteria,1TRZ8@1239|Firmicutes,24BPN@186801|Clostridia,25VV5@186806|Eubacteriaceae	186801|Clostridia	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF1357_C,DUF1537
CMS1_k127_710949_1	1449050.JNLE01000003_gene2968	7.865e-233	739.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,36FQ1@31979|Clostridiaceae	186801|Clostridia	G	beta-galactosidase	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
CMS1_k127_710949_14	180332.JTGN01000002_gene5749	1.558e-87	302.0	COG1609@1|root,COG1609@2|Bacteria,1UXXV@1239|Firmicutes,24A5P@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_710949_11	180332.JTGN01000002_gene5748	1.817e-111	366.0	COG0395@1|root,COG0395@2|Bacteria,1TSGI@1239|Firmicutes,24BDH@186801|Clostridia	186801|Clostridia	P	binding-protein-dependent transport systems inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_710949_12	180332.JTGN01000002_gene5747	9.456e-110	361.0	COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,2494U@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025,ko:K10189	ko02010,map02010	M00199,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.4	-	-	BPD_transp_1
CMS1_k127_710949_4	180332.JTGN01000002_gene5746	1.011e-177	566.0	COG1653@1|root,COG1653@2|Bacteria,1TQ0V@1239|Firmicutes,2481M@186801|Clostridia	186801|Clostridia	G	solute-binding protein	-	-	-	ko:K10188	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_710949_8	158190.SpiGrapes_2691	3.954e-151	484.0	COG0758@1|root,COG0758@2|Bacteria,2J6UM@203691|Spirochaetes	203691|Spirochaetes	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
CMS1_k127_710949_16	158190.SpiGrapes_2692	1.322e-82	276.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS1_k127_711744_2	158190.SpiGrapes_2624	4.914e-26	108.0	COG2355@1|root,COG2355@2|Bacteria,2J8PX@203691|Spirochaetes	203691|Spirochaetes	E	PFAM peptidase M19 renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
CMS1_k127_711744_1	158190.SpiGrapes_2623	8.285e-56	196.0	COG3118@1|root,COG3118@2|Bacteria,2J865@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS1_k127_711744_0	158190.SpiGrapes_2622	2.009e-161	510.0	COG0133@1|root,COG0133@2|Bacteria,2J5J8@203691|Spirochaetes	203691|Spirochaetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS1_k127_711945_2	158190.SpiGrapes_3152	1.79e-117	378.0	COG0624@1|root,COG0624@2|Bacteria,2J6C1@203691|Spirochaetes	203691|Spirochaetes	E	Selenium metabolism hydrolase	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
CMS1_k127_711945_1	158190.SpiGrapes_3151	1.474e-269	831.0	COG0402@1|root,COG0402@2|Bacteria,2J5A0@203691|Spirochaetes	203691|Spirochaetes	F	selenium metabolism protein SsnA	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS1_k127_711945_0	158190.SpiGrapes_3150	0.0	1926.0	COG0493@1|root,COG1036@1|root,COG0493@2|Bacteria,COG1036@2|Bacteria,2J6YZ@203691|Spirochaetes	203691|Spirochaetes	C	Selenate reductase YgfK	gltD	-	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
CMS1_k127_711945_3	158190.SpiGrapes_3145	9.127e-78	261.0	COG0031@1|root,COG0031@2|Bacteria,2J9V1@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
CMS1_k127_719518_2	158190.SpiGrapes_0807	2.449e-147	471.0	COG1073@1|root,COG1073@2|Bacteria,2J5GE@203691|Spirochaetes	203691|Spirochaetes	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Peptidase_S9
CMS1_k127_719518_7	158190.SpiGrapes_0806	3.967e-93	314.0	COG2199@1|root,COG2199@2|Bacteria,2J7TH@203691|Spirochaetes	203691|Spirochaetes	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_719518_8	158190.SpiGrapes_0806	1.214e-07	55.0	COG2199@1|root,COG2199@2|Bacteria,2J7TH@203691|Spirochaetes	203691|Spirochaetes	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_719518_4	158190.SpiGrapes_0805	1.428e-136	439.0	28N6F@1|root,30YAD@2|Bacteria,2J8VC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_719518_5	158190.SpiGrapes_0804	3.909e-116	377.0	COG2755@1|root,COG2755@2|Bacteria,2J7TU@203691|Spirochaetes	203691|Spirochaetes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS1_k127_719518_0	158190.SpiGrapes_0802	0.0	1008.0	COG1164@1|root,COG1164@2|Bacteria,2J5JT@203691|Spirochaetes	203691|Spirochaetes	E	oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
CMS1_k127_719518_6	158190.SpiGrapes_0801	1.466e-100	330.0	COG0127@1|root,COG0127@2|Bacteria,2J7BY@203691|Spirochaetes	203691|Spirochaetes	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
CMS1_k127_719518_1	158190.SpiGrapes_0799	2.671e-172	542.0	COG0618@1|root,COG0618@2|Bacteria,2J6GG@203691|Spirochaetes	203691|Spirochaetes	S	DHH superfamily protein, subfamily 1	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS1_k127_746690_2	748727.CLJU_c25860	9.722e-48	177.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,36EHN@31979|Clostridiaceae	186801|Clostridia	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
CMS1_k127_746690_0	748727.CLJU_c25840	2.515e-147	473.0	COG1063@1|root,COG1063@2|Bacteria,1VUXM@1239|Firmicutes,24CYY@186801|Clostridia,36HSI@31979|Clostridiaceae	186801|Clostridia	C	Glucose dehydrogenase C-terminus	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
CMS1_k127_746690_1	332101.JIBU02000020_gene2055	9.508e-50	179.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,24BSK@186801|Clostridia,36HD5@31979|Clostridiaceae	186801|Clostridia	G	Transketolase, thiamine diphosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Transketolase_N
CMS1_k127_749932_1	1121441.AUCX01000031_gene1709	8.377e-27	113.0	COG3549@1|root,COG3549@2|Bacteria,1NABH@1224|Proteobacteria,42VNZ@68525|delta/epsilon subdivisions,2WRK8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Plasmid maintenance system killer	-	-	-	-	-	-	-	-	-	-	-	-	HigB-like_toxin
CMS1_k127_749932_2	158190.SpiGrapes_2410	1.041e-05	48.0	COG2856@1|root,COG3093@1|root,COG2856@2|Bacteria,COG3093@2|Bacteria,2J9C8@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,Peptidase_M78
CMS1_k127_749932_0	158190.SpiGrapes_2410	1.217e-184	580.0	COG2856@1|root,COG3093@1|root,COG2856@2|Bacteria,COG3093@2|Bacteria,2J9C8@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,Peptidase_M78
CMS1_k127_791888_10	158190.SpiGrapes_2984	7.821e-181	568.0	COG4214@1|root,COG4214@2|Bacteria,2J5AE@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
CMS1_k127_791888_14	158190.SpiGrapes_2983	1.487e-163	521.0	COG1879@1|root,COG1879@2|Bacteria,2JBGK@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, LacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_4
CMS1_k127_791888_25	158190.SpiGrapes_2982	1.44e-67	230.0	COG0799@1|root,COG0799@2|Bacteria,2J84Q@203691|Spirochaetes	203691|Spirochaetes	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
CMS1_k127_791888_31	1048834.TC41_2130	6.716e-19	94.0	COG1713@1|root,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,4HHRY@91061|Bacilli,278CY@186823|Alicyclobacillaceae	91061|Bacilli	H	HD domain	yqeK	-	-	-	-	-	-	-	-	-	-	-	HD
CMS1_k127_791888_18	158190.SpiGrapes_2979	6.285e-108	352.0	COG1057@1|root,COG1057@2|Bacteria,2J65I@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
CMS1_k127_791888_6	158190.SpiGrapes_2978	3.479e-218	678.0	COG0536@1|root,COG0536@2|Bacteria,2J5QY@203691|Spirochaetes	203691|Spirochaetes	C	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1,Radical_SAM
CMS1_k127_791888_27	158190.SpiGrapes_2977	5.066e-45	163.0	COG0211@1|root,COG0211@2|Bacteria,2J967@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
CMS1_k127_791888_26	158190.SpiGrapes_2976	2.149e-55	196.0	COG0261@1|root,COG0261@2|Bacteria,2J7PP@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
CMS1_k127_791888_21	158190.SpiGrapes_2975	2.658e-96	317.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	MA20_10010	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_791888_0	158190.SpiGrapes_2974	0.0	1017.0	COG0018@1|root,COG0018@2|Bacteria,2J5EP@203691|Spirochaetes	203691|Spirochaetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CMS1_k127_791888_15	158190.SpiGrapes_2973	2.732e-145	467.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,2J79B@203691|Spirochaetes	203691|Spirochaetes	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
CMS1_k127_791888_22	158190.SpiGrapes_2972	1.764e-87	296.0	COG1268@1|root,COG1268@2|Bacteria,2J6QE@203691|Spirochaetes	203691|Spirochaetes	S	BioY family	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
CMS1_k127_791888_13	158190.SpiGrapes_2971	3.394e-171	541.0	COG1045@1|root,COG1045@2|Bacteria,2J73S@203691|Spirochaetes	203691|Spirochaetes	E	Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
CMS1_k127_791888_30	935845.JADQ01000007_gene1658	3.186e-35	141.0	COG1670@1|root,COG1670@2|Bacteria,1V1ZC@1239|Firmicutes,4HIDR@91061|Bacilli,274T4@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
CMS1_k127_791888_3	158190.SpiGrapes_2969	4.976e-246	765.0	COG0621@1|root,COG0621@2|Bacteria,2J5SB@203691|Spirochaetes	203691|Spirochaetes	J	Radical SAM methylthiotransferase, MiaB RimO family	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
CMS1_k127_791888_16	158189.SpiBuddy_1986	3.809e-119	391.0	COG0287@1|root,COG0287@2|Bacteria	2|Bacteria	E	prephenate dehydrogenase (NADP+) activity	-	-	1.1.1.169,1.3.1.12,4.2.1.51,5.4.99.5	ko:K00077,ko:K00210,ko:K06410,ko:K14170,ko:K16182	ko00300,ko00400,ko00401,ko00770,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map00400,map00401,map00770,map01100,map01110,map01120,map01130,map01230	M00024,M00025,M00119	R00691,R01373,R01715,R01728,R02472,R10012	RC00062,RC00125,RC00360,RC00726,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,DUF1932,F420_oxidored,NAD_binding_2,PDH
CMS1_k127_791888_9	158190.SpiGrapes_2967	2.994e-182	577.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	ydiM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_791888_8	158190.SpiGrapes_2966	1.7e-183	579.0	COG0280@1|root,COG0280@2|Bacteria,2J5DS@203691|Spirochaetes	203691|Spirochaetes	C	phosphate acetyltransferase	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
CMS1_k127_791888_5	158190.SpiGrapes_2965	6.279e-224	704.0	COG0534@1|root,COG0534@2|Bacteria,2J7HX@203691|Spirochaetes	203691|Spirochaetes	V	PFAM multi antimicrobial extrusion protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_791888_28	1307761.L21SP2_1123	4.115e-37	152.0	COG0030@1|root,COG0030@2|Bacteria,2J65T@203691|Spirochaetes	203691|Spirochaetes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
CMS1_k127_791888_11	158190.SpiGrapes_2963	1.09e-178	571.0	COG0658@1|root,COG0658@2|Bacteria	2|Bacteria	S	establishment of competence for transformation	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
CMS1_k127_791888_17	158190.SpiGrapes_2962	2.981e-109	358.0	2C8CU@1|root,348FB@2|Bacteria,2JASE@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_791888_1	158190.SpiGrapes_2961	3.406e-304	939.0	COG1109@1|root,COG1109@2|Bacteria,2J5QI@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	cpsG	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS1_k127_791888_29	1226322.HMPREF1545_01223	1.95e-36	148.0	COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24HZR@186801|Clostridia,2N78D@216572|Oscillospiraceae	186801|Clostridia	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_791888_4	158190.SpiGrapes_2959	5.711e-242	755.0	COG1092@1|root,COG1092@2|Bacteria,2J6UJ@203691|Spirochaetes	203691|Spirochaetes	J	PFAM S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
CMS1_k127_791888_19	158190.SpiGrapes_2958	2.071e-103	339.0	COG0727@1|root,COG0727@2|Bacteria,2J6XI@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS1_k127_791888_7	158190.SpiGrapes_2957	1.094e-190	599.0	COG0598@1|root,COG0598@2|Bacteria,2J5ZI@203691|Spirochaetes	203691|Spirochaetes	P	PFAM CorA-like Mg2 transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS1_k127_791888_20	158190.SpiGrapes_2956	3.532e-99	325.0	COG2316@1|root,COG2316@2|Bacteria,2J7SZ@203691|Spirochaetes	203691|Spirochaetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS1_k127_791888_2	158190.SpiGrapes_2955	6.675e-267	828.0	2A76W@1|root,30W2Y@2|Bacteria,2JADI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_791888_12	158190.SpiGrapes_2954	8.154e-172	544.0	COG0044@1|root,COG0044@2|Bacteria,2J6KK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS1_k127_791888_23	158190.SpiGrapes_2953	7.273e-74	250.0	COG0167@1|root,COG0543@1|root,COG0167@2|Bacteria,COG0543@2|Bacteria,2J610@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,DHO_dh,FAD_binding_6
CMS1_k127_803084_2	158190.SpiGrapes_0675	9.329e-202	628.0	COG0372@1|root,COG0372@2|Bacteria,2J571@203691|Spirochaetes	203691|Spirochaetes	C	citrate synthase	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS1_k127_803084_8	5722.XP_001299091.1	2.316e-40	161.0	COG0637@1|root,KOG2914@2759|Eukaryota	2759|Eukaryota	L	pseudouridine 5'-phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS1_k127_803084_1	158190.SpiGrapes_0677	2.929e-224	699.0	COG0538@1|root,COG0538@2|Bacteria,2J5RP@203691|Spirochaetes	203691|Spirochaetes	C	PFAM isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS1_k127_803084_0	158190.SpiGrapes_0678	0.0	1149.0	COG1048@1|root,COG1048@2|Bacteria,2J5QT@203691|Spirochaetes	203691|Spirochaetes	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
CMS1_k127_803084_3	158190.SpiGrapes_0679	1.082e-193	610.0	COG0477@1|root,COG2814@2|Bacteria,2JAP5@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08153,ko:K19576	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.10,2.A.1.2.8	-	-	MFS_1
CMS1_k127_803084_6	158190.SpiGrapes_0680	1.149e-81	273.0	COG1963@1|root,COG1963@2|Bacteria,2J7WX@203691|Spirochaetes	203691|Spirochaetes	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
CMS1_k127_803084_5	158190.SpiGrapes_0681	1.062e-139	447.0	COG0834@1|root,COG0834@2|Bacteria,2J7X2@203691|Spirochaetes	203691|Spirochaetes	ET	PFAM Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS1_k127_803084_4	158190.SpiGrapes_0682	3.159e-143	456.0	COG0834@1|root,COG0834@2|Bacteria,2J7X2@203691|Spirochaetes	203691|Spirochaetes	ET	PFAM Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS1_k127_803084_9	1294142.CINTURNW_1185	4.625e-40	153.0	2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia,36JKZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B561
CMS1_k127_803084_7	158190.SpiGrapes_0685	2.064e-72	246.0	COG0765@1|root,COG0765@2|Bacteria,2J5BG@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
CMS1_k127_818358_12	158190.SpiGrapes_0237	2.998e-83	278.0	COG2197@1|root,COG2197@2|Bacteria,2JA92@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS1_k127_818358_1	158190.SpiGrapes_0236	2.044e-275	849.0	COG1653@1|root,COG1653@2|Bacteria,2J71X@203691|Spirochaetes	203691|Spirochaetes	G	extracellular solute-binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_818358_4	158190.SpiGrapes_0235	4.574e-173	547.0	COG1175@1|root,COG1175@2|Bacteria,2J6AN@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_818358_6	158190.SpiGrapes_0234	1.459e-151	486.0	COG0395@1|root,COG0395@2|Bacteria,2J5TD@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_818358_0	158190.SpiGrapes_0233	0.0	1176.0	COG1472@1|root,COG1472@2|Bacteria,2J9XZ@203691|Spirochaetes	203691|Spirochaetes	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
CMS1_k127_818358_13	693746.OBV_32740	1.167e-73	254.0	COG4845@1|root,COG4845@2|Bacteria,1V5KR@1239|Firmicutes,24HNF@186801|Clostridia,2N7P6@216572|Oscillospiraceae	186801|Clostridia	V	Chloramphenicol acetyltransferase	-	-	2.3.1.28	ko:K19271	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	CAT
CMS1_k127_818358_17	158190.SpiGrapes_2881	3.801e-47	175.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_5,TetR_N
CMS1_k127_818358_14	1298920.KI911353_gene2121	9.97e-62	224.0	COG0584@1|root,COG0584@2|Bacteria,1V404@1239|Firmicutes,24EP5@186801|Clostridia	186801|Clostridia	C	Domain of unknown function	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	DUF4996,GDPD
CMS1_k127_818358_15	742733.HMPREF9469_03235	7.322e-49	181.0	COG1683@1|root,COG1683@2|Bacteria,1V700@1239|Firmicutes,24JD2@186801|Clostridia,220MM@1506553|Lachnoclostridium	186801|Clostridia	S	Protein of unknown function (DUF523)	-	-	-	-	-	-	-	-	-	-	-	-	DUF523
CMS1_k127_818358_7	931276.Cspa_c22770	3.23e-148	475.0	COG0702@1|root,COG0702@2|Bacteria,1TT90@1239|Firmicutes,24CA7@186801|Clostridia	186801|Clostridia	GM	NmrA-like family	-	-	1.6.5.2	ko:K19267	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10,NmrA
CMS1_k127_818358_11	931276.Cspa_c22760	4.598e-93	314.0	COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24HPS@186801|Clostridia,36KGZ@31979|Clostridiaceae	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
CMS1_k127_818358_16	158190.SpiGrapes_0222	7.628e-49	181.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_5
CMS1_k127_818358_5	158190.SpiGrapes_0219	2.771e-155	502.0	COG4690@1|root,COG4690@2|Bacteria	2|Bacteria	E	dipeptidase activity	-	-	-	ko:K14358	-	-	-	-	ko00000,ko01002	-	-	-	AAT,Peptidase_C69
CMS1_k127_818358_18	469596.HMPREF9488_03626	1.002e-46	175.0	COG1670@1|root,COG1670@2|Bacteria,1V54D@1239|Firmicutes	1239|Firmicutes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS1_k127_818358_10	158190.SpiGrapes_0510	5.8e-102	340.0	COG0697@1|root,COG0697@2|Bacteria,2J7G2@203691|Spirochaetes	203691|Spirochaetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS1_k127_818358_19	332101.JIBU02000031_gene3086	1.588e-42	162.0	COG4954@1|root,COG4954@2|Bacteria,1V9Z7@1239|Firmicutes,24HGY@186801|Clostridia,36J3R@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF2000)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2000
CMS1_k127_818358_9	158190.SpiGrapes_0511	4.091e-113	372.0	COG2207@1|root,COG2207@2|Bacteria,2J6QI@203691|Spirochaetes	203691|Spirochaetes	K	AraC family	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
CMS1_k127_818358_2	158190.SpiGrapes_0218	2.431e-267	826.0	COG0160@1|root,COG0160@2|Bacteria,2J5WT@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.76	ko:K00836	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	M00033	R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS1_k127_818358_3	906968.Trebr_0036	1.023e-191	609.0	COG0076@1|root,COG0076@2|Bacteria,2J6JJ@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.86	ko:K13745	ko00260,ko01120,map00260,map01120	-	R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
CMS1_k127_818358_8	158190.SpiGrapes_0215	3.986e-116	383.0	COG2199@1|root,COG2199@2|Bacteria,2J7TH@203691|Spirochaetes	203691|Spirochaetes	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_826346_0	158190.SpiGrapes_2306	5.648e-232	726.0	COG0557@1|root,COG0557@2|Bacteria,2J5ZU@203691|Spirochaetes	203691|Spirochaetes	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
CMS1_k127_826346_2	1195236.CTER_2269	1.279e-60	224.0	COG2199@1|root,COG2199@2|Bacteria,1TT99@1239|Firmicutes,24CR1@186801|Clostridia,3WJIF@541000|Ruminococcaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA_7TM
CMS1_k127_826346_1	86416.Clopa_3858	7.803e-84	284.0	COG1794@1|root,COG1794@2|Bacteria,1TR3U@1239|Firmicutes,24ADY@186801|Clostridia,36G2E@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the aspartate glutamate racemases family	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS14520	Asp_Glu_race
CMS1_k127_82939_1	158190.SpiGrapes_2776	8.368e-146	464.0	COG2890@1|root,COG2890@2|Bacteria	2|Bacteria	J	protein-(glutamine-N5) methyltransferase activity	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
CMS1_k127_82939_2	158190.SpiGrapes_2775	5.725e-48	172.0	COG2197@1|root,COG2197@2|Bacteria,2JBHD@203691|Spirochaetes	2|Bacteria	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,GerE,Mor,Response_reg,Y_Y_Y
CMS1_k127_82939_0	158190.SpiGrapes_2896	1.047e-231	718.0	COG3437@1|root,COG3437@2|Bacteria,2J7TZ@203691|Spirochaetes	203691|Spirochaetes	T	response regulator	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
CMS1_k127_82939_3	158190.SpiGrapes_2895	4.133e-12	66.0	COG3437@1|root,COG3437@2|Bacteria,2J7TZ@203691|Spirochaetes	203691|Spirochaetes	T	response regulator	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
CMS1_k127_835857_4	661478.OP10G_2751	7.336e-65	239.0	COG1621@1|root,COG1621@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 32 family	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32C,Glyco_hydro_32N
CMS1_k127_835857_0	478749.BRYFOR_08171	1.053e-165	527.0	COG4733@1|root,COG4733@2|Bacteria,1UI04@1239|Firmicutes,25E8W@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
CMS1_k127_835857_3	33035.JPJF01000057_gene3102	3.316e-124	404.0	COG0395@1|root,COG0395@2|Bacteria,1TSJ9@1239|Firmicutes,24ERB@186801|Clostridia,3Y1FC@572511|Blautia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_835857_2	1298920.KI911353_gene4730	7.094e-129	417.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia,21ZRM@1506553|Lachnoclostridium	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_835857_1	478749.BRYFOR_08174	3.631e-161	517.0	COG1653@1|root,COG1653@2|Bacteria,1TQJU@1239|Firmicutes,24AHT@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
CMS1_k127_835857_5	158190.SpiGrapes_1252	6.826e-50	185.0	COG1476@1|root,COG2932@1|root,COG1476@2|Bacteria,COG2932@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HTH_3,Peptidase_S24,Phage_CI_repr
CMS1_k127_835857_6	331678.Cphamn1_1674	3.39e-11	65.0	COG1715@1|root,COG1715@2|Bacteria	2|Bacteria	V	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	HARE-HTH,Mrr_cat
CMS1_k127_839618_12	573413.Spirs_0994	7.225e-06	49.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS1_k127_839618_7	706587.Desti_4656	7.372e-67	235.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,42R5R@68525|delta/epsilon subdivisions,2WMRR@28221|Deltaproteobacteria,2MR65@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
CMS1_k127_839618_8	113395.AXAI01000014_gene234	8.595e-62	222.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TR6T@28211|Alphaproteobacteria,3JR59@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	MA20_26560	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
CMS1_k127_839618_10	706587.Desti_4232	6.019e-34	146.0	COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,42UTS@68525|delta/epsilon subdivisions,2WQM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
CMS1_k127_839618_9	1120973.AQXL01000068_gene21	7.516e-44	171.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,4HBFZ@91061|Bacilli	91061|Bacilli	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
CMS1_k127_839618_11	1230342.CTM_26267	1.802e-13	83.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,36DTA@31979|Clostridiaceae	186801|Clostridia	E	PFAM Extracellular ligand-binding receptor	braC	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
CMS1_k127_839618_6	1235792.C808_03802	2.404e-104	348.0	COG2513@1|root,COG2513@2|Bacteria,1TQVY@1239|Firmicutes,24AC5@186801|Clostridia	186801|Clostridia	GM	phosphoenolpyruvate	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
CMS1_k127_839618_1	702113.PP1Y_AT5354	6.652e-124	404.0	COG2513@1|root,COG2513@2|Bacteria,1NSNW@1224|Proteobacteria,2UQIU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
CMS1_k127_839618_0	428125.CLOLEP_00209	1.508e-180	578.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3WNKR@541000|Ruminococcaceae	186801|Clostridia	G	COG COG1070 Sugar (pentulose and hexulose) kinases	-	-	2.7.1.53	ko:K00880	ko00040,ko00053,map00040,map00053	-	R01901,R07127	RC00002,RC00017,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
CMS1_k127_839618_5	158190.SpiGrapes_0620	5.482e-106	348.0	COG0235@1|root,COG0235@2|Bacteria,2J6M1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Class II Aldolase and Adducin N-terminal domain	-	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
CMS1_k127_839618_2	411470.RUMGNA_02536	2.195e-117	389.0	28IPH@1|root,2Z8PG@2|Bacteria,1TREB@1239|Firmicutes,248QM@186801|Clostridia,3Y18D@572511|Blautia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_839618_4	1125725.HMPREF1325_2660	4.704e-108	357.0	COG3623@1|root,COG3623@2|Bacteria,2J73T@203691|Spirochaetes	203691|Spirochaetes	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
CMS1_k127_839618_3	1499967.BAYZ01000022_gene213	3.73e-117	386.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	Z012_01010	-	-	ko:K17207,ko:K17215	ko02010,map02010	M00591,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.15	-	-	ABC_tran
CMS1_k127_855592_0	158190.SpiGrapes_0246	4.658e-215	672.0	COG0587@1|root,COG0587@2|Bacteria,2J5DA@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase	-	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
CMS1_k127_855592_1	526218.Sterm_3755	3.32e-71	243.0	arCOG12597@1|root,2ZBJR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_855592_2	1123274.KB899416_gene2699	5.169e-21	93.0	COG0645@1|root,COG0645@2|Bacteria	2|Bacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33
CMS1_k127_861364_4	158190.SpiGrapes_0240	1.663e-80	274.0	COG1418@1|root,COG1418@2|Bacteria,2J8CU@203691|Spirochaetes	203691|Spirochaetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
CMS1_k127_861364_5	158190.SpiGrapes_0241	5.579e-69	245.0	COG0778@1|root,COG0778@2|Bacteria,2J8VG@203691|Spirochaetes	203691|Spirochaetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
CMS1_k127_861364_1	158190.SpiGrapes_0244	4.873e-140	447.0	COG1801@1|root,COG1801@2|Bacteria,2J5GQ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
CMS1_k127_861364_3	545695.TREAZ_1048	3.409e-83	291.0	COG0389@1|root,COG0389@2|Bacteria,2J5SS@203691|Spirochaetes	203691|Spirochaetes	L	DNA-directed DNA polymerase	-	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS
CMS1_k127_861364_0	158190.SpiGrapes_0246	4.409e-247	773.0	COG0587@1|root,COG0587@2|Bacteria,2J5DA@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase	-	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
CMS1_k127_874786_0	397287.C807_03784	2.603e-151	485.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,27IFR@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
CMS1_k127_874786_2	1227352.C173_16049	5.071e-79	273.0	COG0395@1|root,COG0395@2|Bacteria,1TPIF@1239|Firmicutes,4HE61@91061|Bacilli,26Q9R@186822|Paenibacillaceae	91061|Bacilli	P	Sugar ABC transporter ATP-binding protein	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_874786_1	357809.Cphy_0527	2.581e-89	304.0	COG1175@1|root,COG1175@2|Bacteria,1TRC0@1239|Firmicutes,25C59@186801|Clostridia,21ZI6@1506553|Lachnoclostridium	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_874786_3	1347369.CCAD010000012_gene2422	2.513e-47	186.0	COG1653@1|root,COG1653@2|Bacteria,1UYSZ@1239|Firmicutes,4HEMH@91061|Bacilli,1ZC40@1386|Bacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_89617_1	158190.SpiGrapes_0860	3.544e-220	684.0	COG3535@1|root,COG3535@2|Bacteria,2JAMX@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF917)	-	-	-	ko:K09703	-	-	-	-	ko00000	-	-	-	DUF917
CMS1_k127_89617_0	158190.SpiGrapes_0861	1.658e-244	760.0	COG1457@1|root,COG1457@2|Bacteria,2J6MY@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Permease for cytosine purines, uracil, thiamine, allantoin	-	-	-	ko:K10974	-	-	-	-	ko00000,ko02000	2.A.39.1	-	-	Transp_cyt_pur
CMS1_k127_89617_2	158190.SpiGrapes_0862	8.883e-77	260.0	COG3835@1|root,COG3835@2|Bacteria	2|Bacteria	KT	positive regulation of transcription, DNA-templated	-	-	-	ko:K02647,ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	Diacid_rec,GAF_2,HTH_30,PucR
CMS1_k127_896720_0	158190.SpiGrapes_0191	3.634e-162	522.0	COG5002@1|root,COG5002@2|Bacteria,2J755@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
CMS1_k127_931293_0	158190.SpiGrapes_0441	0.0	1039.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2J5YW@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
CMS1_k127_94594_5	1348635.BBJY01000020_gene2759	0.0005772	48.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,1SYMT@1236|Gammaproteobacteria,1Y2VS@135623|Vibrionales	135623|Vibrionales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_94594_1	1300150.EMQU_1023	4.352e-85	292.0	COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,4HA5B@91061|Bacilli,4B20F@81852|Enterococcaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_94594_3	1304866.K413DRAFT_3148	1.428e-48	190.0	COG1653@1|root,COG1653@2|Bacteria,1TQ6X@1239|Firmicutes,24B3P@186801|Clostridia,36GM3@31979|Clostridiaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8,TAT_signal
CMS1_k127_94594_0	754027.HMPREF9554_01997	5.806e-185	582.0	COG2220@1|root,COG2220@2|Bacteria,2J887@203691|Spirochaetes	203691|Spirochaetes	S	Beta-lactamase superfamily domain	-	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactamase_B_3
CMS1_k127_94594_2	1232449.BAHV02000019_gene1366	2.497e-64	229.0	COG1349@1|root,COG1349@2|Bacteria,1UYQX@1239|Firmicutes,24B42@186801|Clostridia	186801|Clostridia	K	transcriptional regulator DeoR family	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
CMS1_k127_947949_0	158190.SpiGrapes_2302	0.0	1575.0	COG0841@1|root,COG0841@2|Bacteria,2J5HW@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS1_k127_947949_3	158190.SpiGrapes_2303	2.326e-51	182.0	2EAU9@1|root,334VX@2|Bacteria,2J94M@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_947949_4	158189.SpiBuddy_2751	3.986e-48	179.0	COG1720@1|root,COG1720@2|Bacteria,2J89H@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
CMS1_k127_947949_2	573413.Spirs_4223	6.54e-61	220.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,2J8TT@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial transcription activator, effector binding	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,HTH_18
CMS1_k127_947949_1	1123274.KB899420_gene4106	1.817e-86	296.0	COG1609@1|root,COG1609@2|Bacteria,2J6QG@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_953194_0	1125725.HMPREF1325_1367	7.216e-67	233.0	COG0627@1|root,COG0627@2|Bacteria,2J6QR@203691|Spirochaetes	203691|Spirochaetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS1_k127_953194_1	573413.Spirs_3032	6.643e-38	155.0	COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HTH_27,MarR,MarR_2,ROK
CMS1_k127_960245_1	1125725.HMPREF1325_2182	3.244e-90	300.0	COG1879@1|root,COG1879@2|Bacteria,2J726@203691|Spirochaetes	2|Bacteria	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
CMS1_k127_960245_0	573413.Spirs_2706	1.709e-180	578.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10441,ko:K10542,ko:K10545,ko:K10548,ko:K17215	ko02010,map02010	M00212,M00214,M00215,M00216,M00221,M00593	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.4,3.A.1.2.5	-	-	ABC_tran
CMS1_k127_961046_10	994573.T472_0213635	2.993e-42	175.0	COG0471@1|root,COG0471@2|Bacteria,1W70M@1239|Firmicutes,25N3X@186801|Clostridia,36TQH@31979|Clostridiaceae	186801|Clostridia	P	metal ion transport	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	-
CMS1_k127_961046_6	536227.CcarbDRAFT_2190	8.719e-121	405.0	COG0644@1|root,COG0644@2|Bacteria,1TR0D@1239|Firmicutes,24BE3@186801|Clostridia,36H2N@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
CMS1_k127_961046_0	476272.RUMHYD_02955	4.024e-265	827.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,3XYPI@572511|Blautia	186801|Clostridia	C	oxidoreductase subunit alpha	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
CMS1_k127_961046_7	476272.RUMHYD_02956	9.62e-82	279.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,3Y05Y@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
CMS1_k127_961046_5	742738.HMPREF9460_03466	2.94e-123	402.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,26960@186813|unclassified Clostridiales	186801|Clostridia	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
CMS1_k127_961046_4	1410612.JNKO01000021_gene2824	3.071e-125	411.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia	186801|Clostridia	C	Belongs to the acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
CMS1_k127_961046_11	588581.Cpap_3457	4.675e-24	109.0	COG2020@1|root,COG2020@2|Bacteria,1VPMN@1239|Firmicutes,24W1M@186801|Clostridia	186801|Clostridia	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
CMS1_k127_961046_8	768706.Desor_2727	2.226e-68	242.0	COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,248C8@186801|Clostridia,265H8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
CMS1_k127_961046_9	1151292.QEW_1876	3.946e-60	214.0	COG1309@1|root,COG1309@2|Bacteria,1V7E0@1239|Firmicutes,24HVP@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_961046_3	158190.SpiGrapes_2287	8.202e-130	418.0	COG0627@1|root,COG0627@2|Bacteria,2J6QR@203691|Spirochaetes	203691|Spirochaetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS1_k127_961046_2	158190.SpiGrapes_2288	1.451e-165	526.0	COG1897@1|root,COG1897@2|Bacteria,2J60Z@203691|Spirochaetes	203691|Spirochaetes	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metAA	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	HTS
CMS1_k127_961046_1	158190.SpiGrapes_2289	7.683e-235	731.0	COG2873@1|root,COG2873@2|Bacteria,2J5MU@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Cys Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
CMS1_k127_964757_0	357809.Cphy_0679	4.736e-49	181.0	COG1595@1|root,COG1595@2|Bacteria,1VB37@1239|Firmicutes,24HN7@186801|Clostridia	186801|Clostridia	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_964757_2	357809.Cphy_0680	4.402e-15	85.0	2C4TV@1|root,3062J@2|Bacteria,1TZ36@1239|Firmicutes,25JF4@186801|Clostridia,223KU@1506553|Lachnoclostridium	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_996815_0	158190.SpiGrapes_3043	0.0	1041.0	COG0008@1|root,COG0008@2|Bacteria,2J6KU@203691|Spirochaetes	203691|Spirochaetes	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
CMS1_k127_996815_1	158190.SpiGrapes_3042	2.955e-205	646.0	COG2159@1|root,COG2159@2|Bacteria,2JA39@203691|Spirochaetes	203691|Spirochaetes	S	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
CMS1_k127_996815_2	158190.SpiGrapes_3041	4.218e-103	336.0	COG1592@1|root,COG1592@2|Bacteria,2J5MR@203691|Spirochaetes	203691|Spirochaetes	C	Rubrerythrin	rbr	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS1_k127_996815_8	158190.SpiGrapes_3040	2.969e-59	207.0	COG0735@1|root,COG0735@2|Bacteria,2J8AC@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the Fur family	fur	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS1_k127_996815_6	180332.JTGN01000001_gene5102	3.337e-79	274.0	COG1175@1|root,COG1175@2|Bacteria,1VSHG@1239|Firmicutes,24GUI@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_996815_7	1232453.BAIF02000004_gene1547	5.282e-74	258.0	COG0395@1|root,COG0395@2|Bacteria,1UYHV@1239|Firmicutes,25C4Q@186801|Clostridia	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
CMS1_k127_996815_9	1232453.BAIF02000004_gene1549	1.399e-45	181.0	COG1653@1|root,COG1653@2|Bacteria,1TQHT@1239|Firmicutes,24AJK@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_996815_5	1304880.JAGB01000004_gene1415	3.751e-90	305.0	COG1235@1|root,COG1235@2|Bacteria,1V5BQ@1239|Firmicutes,24HKX@186801|Clostridia	186801|Clostridia	S	Beta-lactamase superfamily domain	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
CMS1_k127_996815_4	180332.JTGN01000001_gene4665	7.203e-100	339.0	COG2271@1|root,COG2271@2|Bacteria,1TS33@1239|Firmicutes,248WJ@186801|Clostridia	186801|Clostridia	G	transporter	glpT	-	-	ko:K02445	-	-	-	-	ko00000,ko02000	2.A.1.4.3	-	-	MFS_1
CMS1_k127_996815_3	158190.SpiGrapes_2277	8.55e-102	342.0	COG1609@1|root,COG1609@2|Bacteria,2J6Q3@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	scrR	-	-	ko:K02529,ko:K03484	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
## 3211 queries scanned
## Total time (seconds): 34.813833236694336
## Rate: 92.23 q/s