## Fri Nov 8 04:39:52 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS1_bin.7.fa -m mmseqs --itype genome -o CMS1_bin.7 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS1_bin.7 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs CMS1_k127_10051_17 1379270.AUXF01000007_gene994 0.0001126 49.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_10051_0 518766.Rmar_1830 2.09e-220 706.0 COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes,1FK1K@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 CMS1_k127_10051_14 324602.Caur_1553 8.005e-38 143.0 COG1146@1|root,COG1146@2|Bacteria,2G75G@200795|Chloroflexi,375SD@32061|Chloroflexia 32061|Chloroflexia C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Fer4_4 CMS1_k127_10051_8 326427.Cagg_0311 4.139e-70 255.0 COG0614@1|root,COG0614@2|Bacteria,2G6EF@200795|Chloroflexi,376B5@32061|Chloroflexia 32061|Chloroflexia P PFAM periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 CMS1_k127_10051_11 861299.J421_2070 2.672e-44 171.0 28NYH@1|root,2ZBVN@2|Bacteria,1ZTSS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Disulphide isomerase - - - - - - - - - - - - Disulph_isomer CMS1_k127_10051_1 323261.Noc_2145 2.239e-145 479.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RZ0N@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH CMS1_k127_10051_15 316274.Haur_4259 5.135e-13 79.0 COG0745@1|root,COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg CMS1_k127_10051_7 1142394.PSMK_09280 4.571e-85 296.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_10051_16 33035.JPJF01000019_gene4309 1.296e-07 63.0 COG3595@1|root,COG3595@2|Bacteria,1VGMF@1239|Firmicutes,24ICY@186801|Clostridia 186801|Clostridia S Putative adhesin - - - - - - - - - - - - DUF4097 CMS1_k127_10051_3 1237149.C900_03643 3.45e-108 358.0 COG0668@1|root,COG0668@2|Bacteria,4NFHD@976|Bacteroidetes,47PJS@768503|Cytophagia 976|Bacteroidetes M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel CMS1_k127_10051_10 290397.Adeh_1780 1.421e-44 180.0 COG0546@1|root,COG0546@2|Bacteria,1RBMZ@1224|Proteobacteria,42RG3@68525|delta/epsilon subdivisions,2WZ2N@28221|Deltaproteobacteria,2Z16Z@29|Myxococcales 28221|Deltaproteobacteria S HAD-hyrolase-like - - 3.6.1.1 ko:K06019 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - HAD_2 CMS1_k127_10051_2 401526.TcarDRAFT_2158 1.85e-118 393.0 COG1063@1|root,COG1063@2|Bacteria,1U5GN@1239|Firmicutes 1239|Firmicutes E PFAM Alcohol dehydrogenase zinc-binding domain protein - - - - - - - - - - - - ADH_N,ADH_zinc_N CMS1_k127_10051_6 187272.Mlg_0017 2.67e-89 310.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WWFN@135613|Chromatiales 135613|Chromatiales H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM CMS1_k127_10051_4 570268.ANBB01000045_gene1159 1.291e-94 316.0 COG0603@1|root,COG0603@2|Bacteria,2I8NZ@201174|Actinobacteria 201174|Actinobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC CMS1_k127_10051_5 983544.Lacal_2774 2.679e-92 321.0 COG0457@1|root,COG1680@1|root,COG0457@2|Bacteria,COG1680@2|Bacteria,4NHVF@976|Bacteroidetes,1HZ8C@117743|Flavobacteriia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase,DUF3471,TPR_2 CMS1_k127_10051_9 439292.Bsel_0027 1.113e-46 171.0 COG0780@1|root,COG0780@2|Bacteria,1TPYC@1239|Firmicutes,4HB14@91061|Bacilli,26P32@186821|Sporolactobacillaceae 91061|Bacilli S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF CMS1_k127_10051_12 455632.SGR_137 1.704e-43 163.0 2DKP5@1|root,32UFC@2|Bacteria,2H28I@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - DUF2867,Polyketide_cyc2 CMS1_k127_10051_13 358823.DF19_05780 3.835e-39 159.0 COG0010@1|root,COG0010@2|Bacteria,2H81I@201174|Actinobacteria 201174|Actinobacteria E Belongs to the arginase family - - 3.5.3.1 ko:K01476 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00134 R00551 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase CMS1_k127_1015490_0 861299.J421_0282 1.235e-147 496.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_1015490_3 1379270.AUXF01000002_gene1233 8.092e-77 268.0 COG0457@1|root,COG2133@1|root,COG0457@2|Bacteria,COG2133@2|Bacteria,1ZUVC@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 CMS1_k127_1015490_4 880073.Calab_0651 1.972e-47 197.0 COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria 2|Bacteria P COGs COG1629 Outer membrane receptor protein mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS1_k127_1015490_2 861299.J421_0468 5.244e-98 356.0 COG0515@1|root,COG0515@2|Bacteria,1ZUHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1015490_1 861299.J421_1230 4.179e-98 356.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1015490_5 861299.J421_0867 7.484e-23 115.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_0867|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1015691_2 926560.KE387027_gene820 1.149e-99 346.0 COG1167@1|root,COG1167@2|Bacteria,1WM9Y@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K helix_turn_helix gluconate operon transcriptional repressor - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR CMS1_k127_1015691_8 1123261.AXDW01000001_gene1365 3.441e-07 64.0 COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,1X8MB@135614|Xanthomonadales 135614|Xanthomonadales CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA CMS1_k127_1015691_6 861299.J421_1172 1.17e-34 139.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_ECF,Sigma70_r2,Sigma70_r4,Sigma70_r4_2 CMS1_k127_1015691_0 58123.JOFJ01000027_gene2790 2.376e-131 434.0 COG0531@1|root,COG0531@2|Bacteria,2H98W@201174|Actinobacteria,4EN0D@85012|Streptosporangiales 201174|Actinobacteria E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS1_k127_1015691_4 338966.Ppro_1413 4.156e-70 256.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,43U7R@69541|Desulfuromonadales 28221|Deltaproteobacteria H Methionine synthase B12-binding module cap domain protein metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans CMS1_k127_1015691_5 515635.Dtur_0729 6.474e-67 235.0 COG5012@1|root,COG5012@2|Bacteria 2|Bacteria T cobalamin binding - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,URO-D CMS1_k127_1015691_7 1191523.MROS_2096 3.767e-15 89.0 COG1410@1|root,COG1410@2|Bacteria 2|Bacteria E methionine synthase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Met_synt_B12 CMS1_k127_1015691_1 1047013.AQSP01000134_gene1338 5.302e-131 435.0 COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria 2|Bacteria H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB CMS1_k127_1015691_3 555779.Dthio_PD3478 3.089e-89 305.0 COG2006@1|root,COG2006@2|Bacteria,1NV7D@1224|Proteobacteria,42ZEV@68525|delta/epsilon subdivisions,2WV1N@28221|Deltaproteobacteria,2M8BU@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 CMS1_k127_1021500_4 136037.KDR16056 1.497e-42 181.0 COG0666@1|root,KOG0504@2759|Eukaryota,39YNX@33154|Opisthokonta,3BFJC@33208|Metazoa,3CU3G@33213|Bilateria,41W8R@6656|Arthropoda,3SG48@50557|Insecta 33208|Metazoa J Ankyrin repeats (many copies) ANKRD50 GO:0006810,GO:0008150,GO:0016192,GO:0016197,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0098876,GO:1990126 - ko:K21440 - - - - ko00000,ko04131 - - - Ank,Ank_2,Ank_4 CMS1_k127_1021500_2 861299.J421_1115 5.706e-81 281.0 COG0457@1|root,COG0457@2|Bacteria,1ZTCW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_1021500_3 876044.IMCC3088_1921 6.201e-58 221.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S3RP@1236|Gammaproteobacteria,1J65B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs - - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 CMS1_k127_1021500_0 1123368.AUIS01000019_gene1214 2.823e-211 691.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,2NE5Q@225057|Acidithiobacillales 1236|Gammaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 CMS1_k127_1021500_1 379066.GAU_3750 4.397e-118 413.0 COG0515@1|root,COG0515@2|Bacteria,1ZURQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1022613_4 1047013.AQSP01000139_gene2329 1.103e-75 276.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS1_k127_1022613_8 1278073.MYSTI_05666 1.446e-58 218.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase CMS1_k127_1022613_7 861299.J421_6212 8.704e-60 223.0 COG3279@1|root,COG3279@2|Bacteria,1ZTKG@142182|Gemmatimonadetes 2|Bacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - EAL,LytTR,Response_reg CMS1_k127_1022613_17 246197.MXAN_2364 5.065e-16 89.0 COG0457@1|root,COG1680@1|root,COG0457@2|Bacteria,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,4396X@68525|delta/epsilon subdivisions,2X4DR@28221|Deltaproteobacteria,2YYTQ@29|Myxococcales 28221|Deltaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase,TPR_2 CMS1_k127_1022613_9 861299.J421_0735 1.669e-58 216.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_0735|- S peptidyl-tyrosine sulfation - - - ko:K13992 - - - - ko00000,ko00194 - - - - CMS1_k127_1022613_3 861299.J421_6212 1.991e-76 266.0 COG3279@1|root,COG3279@2|Bacteria,1ZTKG@142182|Gemmatimonadetes 2|Bacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - EAL,LytTR,Response_reg CMS1_k127_1022613_6 861299.J421_6211 2.164e-70 256.0 COG2972@1|root,COG2972@2|Bacteria,1ZUX6@142182|Gemmatimonadetes 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,His_kinase CMS1_k127_1022613_10 1265310.CCBD010000018_gene4128 1.66e-56 210.0 COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,238NG@1762|Mycobacteriaceae 201174|Actinobacteria S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 CMS1_k127_1022613_12 404589.Anae109_0807 4.185e-29 136.0 COG4276@1|root,COG4276@2|Bacteria,1N6EC@1224|Proteobacteria,42U3N@68525|delta/epsilon subdivisions,2WQTN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Pfam Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc CMS1_k127_1022613_11 861299.J421_0471 7.451e-46 181.0 COG2010@1|root,COG2010@2|Bacteria,1ZUJA@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - - CMS1_k127_1022613_0 861299.J421_4088 2.984e-219 709.0 COG3408@1|root,COG3408@2|Bacteria 2|Bacteria G Glycogen debranching enzyme - - - - - - - - - - - - Bac_rhamnosid6H,GDE_C,SLH CMS1_k127_1022613_2 926560.KE387023_gene2049 5.488e-120 407.0 COG5001@1|root,COG5001@2|Bacteria,1WK20@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4 CMS1_k127_1022613_1 649638.Trad_1018 4.466e-186 604.0 COG1966@1|root,COG1966@2|Bacteria,1WMNS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T 5TM C-terminal transporter carbon starvation CstA - - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM CMS1_k127_1022613_5 393595.ABO_1301 3.242e-73 262.0 COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,1RRFQ@1236|Gammaproteobacteria,1XMB7@135619|Oceanospirillales 135619|Oceanospirillales D COG0003 Oxyanion-translocating ATPase arsA - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase CMS1_k127_1022613_18 592015.HMPREF1705_01440 3.242e-06 53.0 arCOG03655@1|root,32S08@2|Bacteria,3TBHS@508458|Synergistetes 508458|Synergistetes - - - - - - - - - - - - - - - CMS1_k127_1022613_16 143224.JQMD01000002_gene1882 3.37e-16 92.0 2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1HZN8@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 CMS1_k127_1022613_14 861299.J421_0442 5.946e-22 101.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_1022613_13 1123277.KB893185_gene3024 6.704e-23 116.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,47MDX@768503|Cytophagia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS1_k127_1025549_5 1168034.FH5T_04755 8.422e-43 159.0 COG1509@1|root,COG1509@2|Bacteria,4NK6C@976|Bacteroidetes,2FMW5@200643|Bacteroidia 976|Bacteroidetes E KamA family eam - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - - CMS1_k127_1025549_8 861299.J421_6160 2.087e-14 83.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6160|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1025549_6 861299.J421_1230 5.736e-36 152.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1025549_7 1287276.X752_27525 1.732e-33 141.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43JWG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8 CMS1_k127_1025549_9 1122604.JONR01000004_gene851 2.669e-13 75.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - TPR_16 CMS1_k127_1025549_1 706587.Desti_4856 5.443e-163 554.0 COG0457@1|root,COG2114@1|root,COG2888@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG2888@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria 28221|Deltaproteobacteria KLT Family membership - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12 CMS1_k127_1025549_0 1163617.SCD_n00051 7.299e-206 663.0 COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,2VIF1@28216|Betaproteobacteria 28216|Betaproteobacteria C acetyl-CoA hydrolase - - - ko:K18288 ko00660,map00660 - R02407,R10600 RC00012,RC00014 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro CMS1_k127_1025549_2 1255043.TVNIR_3068 2.452e-155 509.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - - CMS1_k127_1025549_10 102232.GLO73106DRAFT_00035500 1.57e-08 68.0 COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1G9PV@1117|Cyanobacteria 1117|Cyanobacteria Q Bacterial pre-peptidase C-terminal domain - - - - - - - - - - - - PPC CMS1_k127_1025549_11 365528.KB891137_gene379 6.235e-08 66.0 COG1361@1|root,COG4625@1|root,COG4719@1|root,COG1361@2|Bacteria,COG4625@2|Bacteria,COG4719@2|Bacteria,2I8F1@201174|Actinobacteria 201174|Actinobacteria M cellulase activity - - - - - - - - - - - - DUF11,He_PIG,fn3 CMS1_k127_1025549_3 1500259.JQLD01000005_gene295 1.864e-113 377.0 COG2040@1|root,COG2040@2|Bacteria,1MUXU@1224|Proteobacteria,2TURU@28211|Alphaproteobacteria,4BBBF@82115|Rhizobiaceae 28211|Alphaproteobacteria E homocysteine S-methyltransferase - - 2.1.1.10 ko:K00547 ko00270,ko01100,ko01110,map00270,map01100,map01110 - R00650 RC00003,RC00035 ko00000,ko00001,ko01000 - - - S-methyl_trans CMS1_k127_1025549_4 517417.Cpar_0230 5.681e-54 210.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,1FDC1@1090|Chlorobi 1090|Chlorobi EG Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 CMS1_k127_1037409_2 234267.Acid_7369 3.253e-203 653.0 COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria 57723|Acidobacteria S PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_3 CMS1_k127_1037409_12 1112214.AHIS01000047_gene2118 9.234e-59 226.0 COG2234@1|root,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,2VF5N@28211|Alphaproteobacteria,2KDVY@204457|Sphingomonadales 204457|Sphingomonadales V Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_1037409_0 1313301.AUGC01000005_gene377 1.907e-315 1023.0 COG1629@1|root,COG4771@2|Bacteria,4NFJJ@976|Bacteroidetes 976|Bacteroidetes P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS1_k127_1037409_7 861299.J421_2170 2.722e-125 425.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1037409_14 292459.STH2345 5.722e-26 121.0 COG1525@1|root,COG1525@2|Bacteria,1VASF@1239|Firmicutes,24G14@186801|Clostridia 186801|Clostridia L PFAM nuclease (SNase nucH - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase CMS1_k127_1037409_8 1449976.KALB_2204 4.746e-124 406.0 COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4DZ0A@85010|Pseudonocardiales 201174|Actinobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 CMS1_k127_1037409_13 1121456.ATVA01000015_gene2393 4.196e-54 207.0 28I4Y@1|root,2Z88D@2|Bacteria,1R95V@1224|Proteobacteria,42RX3@68525|delta/epsilon subdivisions,2WMGE@28221|Deltaproteobacteria,2MECJ@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_1037409_1 880073.Calab_1134 9.637e-228 734.0 COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS1_k127_1037409_11 886293.Sinac_6637 1.29e-81 282.0 COG1163@1|root,COG1163@2|Bacteria,2IWYP@203682|Planctomycetes 203682|Planctomycetes S TGS domain - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS CMS1_k127_1037409_10 1379270.AUXF01000007_gene968 2.771e-88 327.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene968|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_1037409_4 1267535.KB906767_gene447 1.88e-193 630.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y67Y@57723|Acidobacteria,2JMN2@204432|Acidobacteriia 204432|Acidobacteriia T Tetratricopeptide repeat - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_12 CMS1_k127_1037409_5 1267535.KB906767_gene4657 4.578e-138 456.0 COG3852@1|root,COG3852@2|Bacteria,3Y3JR@57723|Acidobacteria,2JIY1@204432|Acidobacteriia 204432|Acidobacteriia T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HATPase_c,cNMP_binding CMS1_k127_1037409_3 111781.Lepto7376_3836 3.063e-200 639.0 COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1HH7U@1150|Oscillatoriales 1117|Cyanobacteria KOT PFAM Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Response_reg CMS1_k127_1037409_15 204669.Acid345_3020 1.041e-11 75.0 COG2834@1|root,COG2834@2|Bacteria,3Y7NW@57723|Acidobacteria 57723|Acidobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - - CMS1_k127_1037409_6 293826.Amet_4112 3.173e-134 437.0 COG0031@1|root,COG0031@2|Bacteria,1UZEQ@1239|Firmicutes,24BCR@186801|Clostridia,36G6F@31979|Clostridiaceae 186801|Clostridia E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_1037409_9 861299.J421_2170 3.496e-113 400.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1048741_0 862908.BMS_3067 6.074e-162 529.0 COG2268@1|root,COG2268@2|Bacteria,1QIR4@1224|Proteobacteria,42Q0N@68525|delta/epsilon subdivisions,2WJDJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Band 7 protein - - - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot CMS1_k127_1048741_10 338963.Pcar_0143 1.424e-21 104.0 29X52@1|root,30IU1@2|Bacteria,1N8YP@1224|Proteobacteria,42WWU@68525|delta/epsilon subdivisions,2WT2G@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_1048741_2 378806.STAUR_7974 5.953e-95 321.0 COG1801@1|root,COG1801@2|Bacteria,1N4QE@1224|Proteobacteria,42PDW@68525|delta/epsilon subdivisions,2WK6H@28221|Deltaproteobacteria,2YVUI@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 CMS1_k127_1048741_9 1246484.D479_14222 3.115e-24 104.0 COG0640@1|root,COG0640@2|Bacteria,1UV3F@1239|Firmicutes,4I4FW@91061|Bacilli,3NG6Q@45667|Halobacillus 91061|Bacilli K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_5 CMS1_k127_1048741_5 1234664.AMRO01000057_gene317 4.003e-51 188.0 COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,4HJDZ@91061|Bacilli,1WFPG@129337|Geobacillus 91061|Bacilli S SdpI/YhfL protein family yvaZ GO:0008150,GO:0009636,GO:0042221,GO:0050896 - - - - - - - - - - DUF1648,SdpI CMS1_k127_1048741_6 685778.AORL01000010_gene2565 2.331e-45 183.0 COG1073@1|root,COG1073@2|Bacteria,1R67P@1224|Proteobacteria,2U3D5@28211|Alphaproteobacteria,2K2QV@204457|Sphingomonadales 204457|Sphingomonadales S Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 CMS1_k127_1048741_3 861299.J421_5976 3.169e-70 251.0 COG1533@1|root,COG1533@2|Bacteria,1ZUFM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM CMS1_k127_1048741_11 861299.J421_1802 2.551e-08 64.0 2F4S7@1|root,33XEY@2|Bacteria,1ZTM4@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1048741_7 1379270.AUXF01000001_gene2636 2.39e-45 188.0 COG0553@1|root,COG0553@2|Bacteria,1ZUB8@142182|Gemmatimonadetes 142182|Gemmatimonadetes L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N CMS1_k127_1048741_1 861299.J421_4374 1.47e-131 457.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1ZT3Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes LV DNA restriction-modification system - - - - - - - - - - - - N6_Mtase CMS1_k127_1048741_12 66429.JOFL01000006_gene2185 1.577e-07 64.0 COG2306@1|root,COG2306@2|Bacteria,2GJP9@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF402) - - - - - - - - - - - - DUF402 CMS1_k127_1048741_4 1242864.D187_004069 2.025e-66 242.0 COG2367@1|root,COG2367@2|Bacteria,1N9HE@1224|Proteobacteria 1224|Proteobacteria V Beta-lactamase class A - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 CMS1_k127_1048741_13 1144275.COCOR_00143 1.179e-05 55.0 COG3795@1|root,COG3795@2|Bacteria,1NJ4J@1224|Proteobacteria 1224|Proteobacteria S YCII-related domain - - - - - - - - - - - - YCII CMS1_k127_1048741_8 1121013.P873_04900 1.165e-29 123.0 COG1595@1|root,COG1595@2|Bacteria,1RI1M@1224|Proteobacteria,1S780@1236|Gammaproteobacteria,1X678@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_1049812_6 1550091.JROE01000002_gene1131 5.287e-25 120.0 COG2312@1|root,COG2312@2|Bacteria,4NW00@976|Bacteroidetes,1ITY5@117747|Sphingobacteriia 976|Bacteroidetes S Erythromycin esterase - - - ko:K06880 - - - - ko00000,ko01000,ko01504 - - - CarbopepD_reg_2,Erythro_esteras CMS1_k127_1049812_7 886293.Sinac_5522 8.485e-18 92.0 COG1595@1|root,COG1595@2|Bacteria,2IZPG@203682|Planctomycetes 203682|Planctomycetes K COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_1049812_8 1123020.AUIE01000001_gene2089 2.932e-07 63.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1YE7K@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Trypsin mucD GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS1_k127_1049812_11 438753.AZC_3801 3.361e-06 53.0 COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - LZ_Tnp_IS481,rve,rve_3 CMS1_k127_1049812_5 240016.ABIZ01000001_gene2036 9.901e-27 121.0 COG0657@1|root,COG0657@2|Bacteria,46SVI@74201|Verrucomicrobia,2IVNB@203494|Verrucomicrobiae 203494|Verrucomicrobiae I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 CMS1_k127_1049812_3 401053.AciPR4_3251 1.795e-47 178.0 COG2318@1|root,COG2318@2|Bacteria,3Y81K@57723|Acidobacteria,2JN5E@204432|Acidobacteriia 204432|Acidobacteriia S DinB family - - - - - - - - - - - - DinB_2 CMS1_k127_1049812_9 1121355.KB903379_gene745 7.778e-07 53.0 COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae 201174|Actinobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N CMS1_k127_1049812_1 861299.J421_3786 4.103e-167 537.0 COG0282@1|root,COG0282@2|Bacteria,1ZT9P@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase CMS1_k127_1049812_4 1318628.MARLIPOL_14455 2.499e-41 166.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg CMS1_k127_1049812_10 1122164.JHWF01000022_gene1733 7.814e-07 57.0 2BNP9@1|root,32HCB@2|Bacteria,1QBYA@1224|Proteobacteria,1T7JI@1236|Gammaproteobacteria,1JFGD@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - CMS1_k127_1049812_0 1191523.MROS_0402 4.74e-209 668.0 COG2978@1|root,COG2978@2|Bacteria 2|Bacteria H secondary active p-aminobenzoyl-glutamate transmembrane transporter activity ydaH - - ko:K12942 - - - - ko00000 - - - ABG_transport CMS1_k127_1049812_2 196162.Noca_0078 2.989e-49 193.0 COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4DPRR@85009|Propionibacteriales 201174|Actinobacteria IQ PFAM short-chain dehydrogenase reductase SDR - - 1.1.1.100,1.1.1.304,1.1.1.76 ko:K00059,ko:K18009 ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R11671 RC00029,RC00117,RC00205,RC00525 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_1049812_12 861299.J421_0429 1.905e-05 55.0 294MB@1|root,2ZS0S@2|Bacteria,1ZU7M@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1057178_1 861299.J421_6150 2.677e-40 156.0 2DF6S@1|root,2ZQP7@2|Bacteria,1ZU7F@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1057178_0 1267533.KB906738_gene2028 3.745e-133 428.0 COG2152@1|root,COG2152@2|Bacteria 2|Bacteria G transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_hydro_130 CMS1_k127_1067254_0 452637.Oter_3293 5.041e-191 613.0 COG0281@1|root,COG0281@2|Bacteria,46UI4@74201|Verrucomicrobia,3K7KY@414999|Opitutae 414999|Opitutae C Malic enzyme, NAD binding domain - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic CMS1_k127_1067254_2 935836.JAEL01000112_gene1313 9.998e-06 57.0 COG0308@1|root,COG0308@2|Bacteria,1U8WK@1239|Firmicutes,4IIV4@91061|Bacilli,1ZD4P@1386|Bacillus 91061|Bacilli E aminopeptidase N - - - - - - - - - - - - - CMS1_k127_1067254_1 945713.IALB_0545 3.844e-16 78.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion - - - - - - - - - - - - Band_7 CMS1_k127_1084849_6 234267.Acid_3665 1.016e-105 374.0 COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria 57723|Acidobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_1084849_1 234267.Acid_3470 9.54e-154 514.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_1084849_3 861299.J421_6226 1.847e-135 462.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_1084849_16 1379270.AUXF01000004_gene3009 6.087e-21 102.0 COG2318@1|root,COG2318@2|Bacteria,1ZU3G@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_1084849_14 344747.PM8797T_21828 6.191e-30 138.0 COG1044@1|root,COG2931@1|root,COG4257@1|root,COG1044@2|Bacteria,COG2931@2|Bacteria,COG4257@2|Bacteria 2|Bacteria V antibiotic catabolic process - - 3.4.24.40 ko:K01406,ko:K02414,ko:K07004,ko:K13277,ko:K21449 ko01503,ko02024,ko02040,map01503,map02024,map02040 - - - ko00000,ko00001,ko01000,ko01002,ko02000,ko02035,ko03110 1.B.40.2 - - DUF5011,Peptidase_S55,VCBS CMS1_k127_1084849_15 861299.J421_6228 9.73e-24 108.0 COG1695@1|root,COG1695@2|Bacteria,1ZV8D@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS1_k127_1084849_0 204669.Acid345_2047 4.692e-161 543.0 COG0577@1|root,COG0577@2|Bacteria,3Y6R1@57723|Acidobacteria,2JMKX@204432|Acidobacteriia 204432|Acidobacteriia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_1084849_11 1379270.AUXF01000004_gene3301 8.658e-50 205.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria 2|Bacteria S CHAT domain - - - - - - - - - - - - CHAT CMS1_k127_1084849_20 483218.BACPEC_00402 5.004e-06 61.0 COG3210@1|root,COG3210@2|Bacteria,1UJPN@1239|Firmicutes,25FF8@186801|Clostridia 186801|Clostridia U endoglucanase-related protein, glucosyl hydrolase family 9 protein K01238 - - - - - - - - - - - - Big_2 CMS1_k127_1084849_17 1379270.AUXF01000004_gene3009 3.581e-18 100.0 COG2318@1|root,COG2318@2|Bacteria,1ZU3G@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_1084849_7 196162.Noca_4929 9.267e-100 336.0 COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria,4DR4D@85009|Propionibacteriales 201174|Actinobacteria IQ KR domain - - 1.1.1.127,1.1.1.69 ko:K00046,ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 CMS1_k127_1084849_5 861299.J421_2199 4.455e-125 436.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_2199|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_1084849_13 861299.J421_0639 9.123e-35 136.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS1_k127_1084849_18 1307437.J139_14215 8.199e-09 65.0 COG1309@1|root,COG1309@2|Bacteria,1RGG1@1224|Proteobacteria,1S5P1@1236|Gammaproteobacteria,2Q4N9@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS1_k127_1084849_8 379066.GAU_3599 2.602e-59 230.0 COG0596@1|root,COG0596@2|Bacteria,1ZUKC@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Alpha beta hydrolase - - - - - - - - - - - - - CMS1_k127_1084849_10 1300345.LF41_3056 1.128e-52 205.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1X631@135614|Xanthomonadales 135614|Xanthomonadales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct CMS1_k127_1084849_4 215803.DB30_8758 4.017e-126 411.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,42P5V@68525|delta/epsilon subdivisions,2WMWE@28221|Deltaproteobacteria,2YU1I@29|Myxococcales 28221|Deltaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb CMS1_k127_1084849_2 1379270.AUXF01000005_gene461 2.39e-147 519.0 COG5000@1|root,COG5000@2|Bacteria,1ZSZU@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c CMS1_k127_1084849_9 861299.J421_2906 1.75e-57 231.0 COG1402@1|root,COG1402@2|Bacteria 2|Bacteria I creatininase - - 3.5.2.10 ko:K01470,ko:K22232 ko00330,ko00562,map00330,map00562 - R01884,R11771 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS1_k127_1084849_21 861299.J421_2905 6.065e-06 59.0 2FH8I@1|root,3492W@2|Bacteria,1ZTXF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1084849_12 861299.J421_2904 1.467e-43 171.0 COG1538@1|root,COG1538@2|Bacteria,1ZSMB@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS1_k127_1096385_4 136993.KB900626_gene727 3.882e-17 83.0 COG1669@1|root,COG1669@2|Bacteria,1NABR@1224|Proteobacteria 1224|Proteobacteria L DNA polymerase beta domain protein region - - - ko:K07075 - - - - ko00000 - - - NTP_transf_2 CMS1_k127_1096385_3 671143.DAMO_3051 2.632e-27 115.0 COG2361@1|root,COG2361@2|Bacteria 2|Bacteria S Protein of unknown function DUF86 - - - - - - - - - - - - DUF86 CMS1_k127_1096385_2 1379270.AUXF01000002_gene1585 2.018e-114 401.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_1096385_0 1379270.AUXF01000002_gene1600 9.178e-175 579.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_1096385_1 1192034.CAP_4888 5.294e-122 400.0 COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2YX5D@29|Myxococcales 28221|Deltaproteobacteria E Aconitase C-terminal domain - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C CMS1_k127_1102219_19 861299.J421_3305 1.381e-08 57.0 COG0776@1|root,COG0776@2|Bacteria,1ZTTN@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions - - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS1_k127_1102219_4 861299.J421_3306 6.862e-145 468.0 COG0505@1|root,COG0505@2|Bacteria,1ZT0T@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Carbamoyl-phosphate synthase small chain, CPSase domain carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase CMS1_k127_1102219_16 379066.GAU_1676 2.159e-22 101.0 COG1314@1|root,COG1314@2|Bacteria,1ZTZS@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Preprotein translocase SecG subunit - - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG CMS1_k127_1102219_8 861299.J421_3308 1.831e-68 242.0 COG0149@1|root,COG0149@2|Bacteria,1ZSYN@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM CMS1_k127_1102219_3 861299.J421_3309 3.692e-156 519.0 COG0126@1|root,COG0126@2|Bacteria,1ZT1B@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK CMS1_k127_1102219_5 379066.GAU_1679 3.238e-143 462.0 COG0057@1|root,COG0057@2|Bacteria,1ZSTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N CMS1_k127_1102219_17 1122604.JONR01000043_gene3173 4.412e-22 109.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1X6Y9@135614|Xanthomonadales 135614|Xanthomonadales S Competence protein - - - - - - - - - - - - Pribosyltran CMS1_k127_1102219_14 1496688.ER33_06170 2.328e-40 160.0 COG0169@1|root,COG0169@2|Bacteria,1G0CS@1117|Cyanobacteria,22RSC@167375|Cyanobium 1117|Cyanobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N CMS1_k127_1102219_15 379066.GAU_1682 9.691e-36 150.0 COG0394@1|root,COG0394@2|Bacteria,1ZTSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Low molecular weight phosphatase family - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc CMS1_k127_1102219_11 861299.J421_3314 2.194e-56 209.0 COG0009@1|root,COG0009@2|Bacteria,1ZT3D@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Telomere recombination - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC CMS1_k127_1102219_13 518766.Rmar_1098 1.195e-43 171.0 COG1211@1|root,COG1211@2|Bacteria,4NMB5@976|Bacteroidetes,1FJAE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 1.1.1.405,2.7.7.40,2.7.7.60 ko:K00991,ko:K21681 ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130 M00096 R01525,R02921,R05633 RC00002,RC00089 ko00000,ko00001,ko00002,ko01000 - - - IspD,LicD,adh_short CMS1_k127_1102219_2 861299.J421_3316 5.295e-164 528.0 COG1066@1|root,COG1066@2|Bacteria,1ZSYF@142182|Gemmatimonadetes 142182|Gemmatimonadetes O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - ATPase CMS1_k127_1102219_1 379066.GAU_1686 4.573e-166 535.0 COG0305@1|root,COG0305@2|Bacteria,1ZSMZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C CMS1_k127_1102219_9 1379270.AUXF01000006_gene204 5.926e-67 239.0 COG1573@1|root,COG1573@2|Bacteria,1ZTG5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG CMS1_k127_1102219_7 861299.J421_3319 7.37e-111 374.0 COG0452@1|root,COG0452@2|Bacteria,1ZV19@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein CMS1_k127_1102219_18 1379270.AUXF01000006_gene203 1.626e-17 93.0 28VAR@1|root,2ZHDJ@2|Bacteria,1ZU25@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - - - - - - - - - - - RNA_pol_Rpb6 CMS1_k127_1102219_12 379066.GAU_1689 3.245e-51 193.0 COG0194@1|root,COG0194@2|Bacteria,1ZTV7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin CMS1_k127_1102219_10 1379270.AUXF01000006_gene201 2.409e-64 231.0 COG1561@1|root,COG1561@2|Bacteria,1ZT99@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N CMS1_k127_1102219_6 266117.Rxyl_1124 1.151e-134 444.0 COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4CPVK@84995|Rubrobacteria 84995|Rubrobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N CMS1_k127_1102219_0 1121403.AUCV01000021_gene3556 3.958e-175 557.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2MI0G@213118|Desulfobacterales 28221|Deltaproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS1_k127_1122007_8 1379270.AUXF01000002_gene1118 4.286e-39 155.0 2CDZB@1|root,3340J@2|Bacteria,1ZU24@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1122007_1 518766.Rmar_0830 1.883e-127 417.0 COG1253@1|root,COG1253@2|Bacteria,4NE7C@976|Bacteroidetes,1FJ4A@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Domain of unknown function DUF21 - - - - - - - - - - - - CBS,DUF21 CMS1_k127_1122007_4 861299.J421_3712 9.556e-82 287.0 COG0577@1|root,COG0577@2|Bacteria,1ZTMQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_1122007_0 379066.GAU_3308 2.538e-180 580.0 COG2234@1|root,COG2234@2|Bacteria,1ZTDG@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS1_k127_1122007_7 762376.AXYL_03276 1.107e-53 196.0 COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2VTAV@28216|Betaproteobacteria,3T3PW@506|Alcaligenaceae 28216|Betaproteobacteria J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - - - - - - - - - - - Acetyltransf_3 CMS1_k127_1122007_6 667014.Thein_0048 4.202e-77 276.0 COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GH0E@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria P Ion channel - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N CMS1_k127_1122007_2 379066.GAU_3347 7.489e-91 310.0 COG2362@1|root,COG2362@2|Bacteria 2|Bacteria E D-aminopeptidase dppA - - ko:K16203 - - - - ko00000,ko01000,ko01002 3.A.1.5.2 - - Peptidase_M55 CMS1_k127_1122007_9 857087.Metme_2194 4.811e-20 104.0 COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1SCF7@1236|Gammaproteobacteria,1XFQV@135618|Methylococcales 135618|Methylococcales S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin CMS1_k127_1122007_5 886293.Sinac_2843 3.52e-81 278.0 COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes 203682|Planctomycetes MV Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide - - - - - - - - - - - - Beta-lactamase,Peptidase_M15 CMS1_k127_1122007_10 1030157.AFMP01000042_gene1291 3.02e-06 56.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,2K57D@204457|Sphingomonadales 204457|Sphingomonadales O subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH CMS1_k127_1122007_3 1232410.KI421418_gene2433 4.032e-90 308.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,42SR8@68525|delta/epsilon subdivisions,2WPN0@28221|Deltaproteobacteria,43U8D@69541|Desulfuromonadales 28221|Deltaproteobacteria S Histidine-specific methyltransferase, SAM-dependent - - 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 CMS1_k127_1127091_1 1249627.D779_4027 1.809e-55 198.0 COG2227@1|root,COG2227@2|Bacteria,1R0T3@1224|Proteobacteria 1224|Proteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 CMS1_k127_1127091_0 1079460.ATTQ01000011_gene2976 1.374e-126 414.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria,4BC24@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - - - - - - - - - - DJ-1_PfpI,HTH_18 CMS1_k127_1129542_2 448385.sce3387 2.764e-33 142.0 COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales 28221|Deltaproteobacteria S cellulose binding - - - - - - - - - - - - - CMS1_k127_1129542_0 1047013.AQSP01000105_gene1455 2.858e-126 420.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_1129542_1 861299.J421_6304 6.219e-74 254.0 COG4447@1|root,COG4447@2|Bacteria,1ZUBH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 CMS1_k127_1133266_10 1047013.AQSP01000142_gene186 8.699e-42 154.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - - - - - - - - - - - DPPIV_N,Peptidase_S9 CMS1_k127_1133266_5 861299.J421_1729 1.304e-87 324.0 COG0515@1|root,COG0515@2|Bacteria,1ZUCF@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1133266_3 530564.Psta_4590 2.851e-111 392.0 COG1294@1|root,COG1294@2|Bacteria,2IY5D@203682|Planctomycetes 203682|Planctomycetes C COG1294 Cytochrome bd-type quinol oxidase subunit 2 - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II CMS1_k127_1133266_2 756272.Plabr_1583 8.763e-194 619.0 COG1271@1|root,COG1271@2|Bacteria,2IXYC@203682|Planctomycetes 203682|Planctomycetes C Cytochrome bd-type quinol oxidase subunit 1 - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I CMS1_k127_1133266_12 1500893.JQNB01000001_gene1846 3.241e-33 142.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,1X7YN@135614|Xanthomonadales 135614|Xanthomonadales T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg CMS1_k127_1133266_11 1267533.KB906738_gene2095 4.514e-35 144.0 COG4191@1|root,COG4585@1|root,COG4191@2|Bacteria,COG4585@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07683 ko02020,map02020 M00483 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - ABC_sub_bind,GAF_2,GGDEF,HATPase_c,HisKA_3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,dCache_1 CMS1_k127_1133266_14 861299.J421_1567 4.544e-16 86.0 2C9D5@1|root,33DH3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1133266_13 379066.GAU_0848 8.91e-19 87.0 COG0267@1|root,COG0267@2|Bacteria,1ZV8A@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L33 - - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 CMS1_k127_1133266_16 1209989.TepiRe1_2329 0.0008714 46.0 COG0690@1|root,COG0690@2|Bacteria,1UEKM@1239|Firmicutes,25JJ4@186801|Clostridia,42HEH@68295|Thermoanaerobacterales 186801|Clostridia U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE CMS1_k127_1133266_6 861299.J421_2762 1.334e-77 270.0 COG0250@1|root,COG0250@2|Bacteria,1ZSS2@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - NusG CMS1_k127_1133266_7 331678.Cphamn1_0315 4.232e-56 198.0 COG0080@1|root,COG0080@2|Bacteria,1FDVE@1090|Chlorobi 1090|Chlorobi J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N CMS1_k127_1133266_4 861299.J421_2764 3.989e-96 327.0 COG0081@1|root,COG0081@2|Bacteria,1ZSS7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 CMS1_k127_1133266_8 861299.J421_2765 7.496e-43 172.0 COG0244@1|root,COG0244@2|Bacteria,1ZTQI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 CMS1_k127_1133266_9 861299.J421_2766 8.433e-42 157.0 COG0222@1|root,COG0222@2|Bacteria,1ZTTC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N CMS1_k127_1133266_0 502025.Hoch_4016 0.0 1277.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 CMS1_k127_1133266_1 861299.J421_2768 0.0 1055.0 COG0086@1|root,COG0086@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 CMS1_k127_1147334_4 379066.GAU_1674 6.124e-45 165.0 COG0776@1|root,COG0776@2|Bacteria,1ZTTN@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions - - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS1_k127_1147334_9 869210.Marky_0307 6.434e-06 55.0 COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1WIMD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - 2.8.1.12 ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE,ThiS CMS1_k127_1147334_7 867903.ThesuDRAFT_00783 2.461e-28 121.0 COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1V3V0@1239|Firmicutes,24QVX@186801|Clostridia 186801|Clostridia H Molybdopterin converting factor subunit - - 2.8.1.12 ko:K03635,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE,ThiS CMS1_k127_1147334_5 264732.Moth_1880 5.548e-43 168.0 COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,42G3A@68295|Thermoanaerobacterales 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase CMS1_k127_1147334_0 861299.J421_3301 1.062e-134 438.0 COG0039@1|root,COG0039@2|Bacteria,1ZSV3@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N CMS1_k127_1147334_3 1379270.AUXF01000004_gene3098 6.831e-49 177.0 COG0720@1|root,COG0720@2|Bacteria,1ZTV2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS CMS1_k127_1147334_1 1279009.ADICEAN_03419 1.136e-106 360.0 COG1404@1|root,COG1404@2|Bacteria,4NI53@976|Bacteroidetes,47MBD@768503|Cytophagia 976|Bacteroidetes O Peptidase S8 - - - - - - - - - - - - Inhibitor_I9,Peptidase_S8 CMS1_k127_1147334_8 871963.Desdi_2259 1.631e-26 123.0 COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,25AZU@186801|Clostridia,264VT@186807|Peptococcaceae 186801|Clostridia M Cell wall-associated hydrolase (invasion-associated protein) spr - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,SH3_3 CMS1_k127_1147334_6 379066.GAU_1535 6.105e-38 145.0 COG0234@1|root,COG0234@2|Bacteria,1ZTZB@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 CMS1_k127_1147334_2 379066.GAU_1536 8.79e-79 265.0 COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS1_k127_1151135_6 379066.GAU_0642 1.086e-88 306.0 COG0520@1|root,COG0520@2|Bacteria,1ZTDV@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS1_k127_1151135_9 1206741.BAFX01000031_gene7699 2.265e-30 130.0 COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4G14T@85025|Nocardiaceae 201174|Actinobacteria FG Scavenger mRNA decapping enzyme C-term binding - - - - - - - - - - - - HIT CMS1_k127_1151135_4 33876.JNXY01000012_gene4122 3.149e-112 377.0 COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,4DBAC@85008|Micromonosporales 201174|Actinobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b CMS1_k127_1151135_0 861299.J421_2591 5.325e-230 733.0 COG5009@1|root,COG5009@2|Bacteria,1ZT3R@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transglycosylase - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase CMS1_k127_1151135_11 236097.ADG881_2922 0.0005814 51.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XITW@135619|Oceanospirillales 135619|Oceanospirillales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N CMS1_k127_1151135_10 1123023.JIAI01000020_gene2075 7.401e-27 117.0 COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4E2KB@85010|Pseudonocardiales 201174|Actinobacteria K Regulates arginine biosynthesis genes argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C CMS1_k127_1151135_2 861299.J421_1323 1.721e-153 494.0 COG0137@1|root,COG0137@2|Bacteria,1ZTYP@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Arginosuccinate synthase argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth CMS1_k127_1151135_3 316274.Haur_4138 1.683e-128 444.0 COG0165@1|root,COG0165@2|Bacteria,2G616@200795|Chloroflexi,375AG@32061|Chloroflexia 32061|Chloroflexia E PFAM fumarate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 CMS1_k127_1151135_5 1379270.AUXF01000004_gene3235 2.479e-89 299.0 COG1403@1|root,COG1403@2|Bacteria,1ZTF1@142182|Gemmatimonadetes 142182|Gemmatimonadetes L HNH nucleases - - - - - - - - - - - - HNH_5 CMS1_k127_1151135_7 861299.J421_2603 8.392e-66 231.0 COG0432@1|root,COG0432@2|Bacteria,1ZV8J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 CMS1_k127_1151135_1 861299.J421_2604 6.394e-196 624.0 COG0318@1|root,COG0318@2|Bacteria,1ZSXP@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C CMS1_k127_1151135_8 1379270.AUXF01000004_gene3227 9.877e-51 184.0 COG1432@1|root,COG1432@2|Bacteria,1ZSRW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH CMS1_k127_1189449_0 518766.Rmar_1740 1.806e-126 409.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA CMS1_k127_1189449_1 760117.JN27_22600 2.077e-55 202.0 2DVZY@1|root,33XWI@2|Bacteria 2|Bacteria S Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core CMS1_k127_1193510_3 1052684.PPM_1323 1.048e-65 229.0 COG2318@1|root,COG2318@2|Bacteria,1V2BI@1239|Firmicutes,4HF8B@91061|Bacilli,26XPE@186822|Paenibacillaceae 91061|Bacilli S Belongs to the metal hydrolase YfiT family yfiT - - - - - - - - - - - DinB_2 CMS1_k127_1193510_2 404589.Anae109_1962 1.589e-68 240.0 COG0500@1|root,COG2226@2|Bacteria,1NV2S@1224|Proteobacteria,43AKS@68525|delta/epsilon subdivisions,2X60S@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 CMS1_k127_1193510_6 313606.M23134_04250 9.67e-43 169.0 COG0451@1|root,COG0451@2|Bacteria,4NEMN@976|Bacteroidetes,47KEU@768503|Cytophagia 976|Bacteroidetes GM NmrA-like family dfrA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase CMS1_k127_1193510_11 523850.TON_0604 9.624e-09 66.0 COG1266@1|root,arCOG05750@2157|Archaea,2XTC5@28890|Euryarchaeota,24431@183968|Thermococci 183968|Thermococci S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS1_k127_1193510_9 1089550.ATTH01000001_gene984 2.333e-17 97.0 2AB5B@1|root,310JH@2|Bacteria,4PF4A@976|Bacteroidetes,1FK43@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_1193510_1 1536775.H70737_09555 1.717e-79 284.0 COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,4HA41@91061|Bacilli,26R6M@186822|Paenibacillaceae 91061|Bacilli M glycosyl transferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_1193510_4 379066.GAU_0686 5.811e-52 207.0 COG0438@1|root,COG0438@2|Bacteria,1ZUNM@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyltransferase Family 4 - - - ko:K14335 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_transf_4 CMS1_k127_1193510_5 861299.J421_4474 6.47e-49 189.0 2FK3F@1|root,34BRJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1193510_10 1379270.AUXF01000007_gene927 5.401e-12 76.0 COG0392@1|root,COG0392@2|Bacteria,1ZSUQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS1_k127_1193510_7 1121104.AQXH01000001_gene1332 1.55e-34 150.0 2ECQK@1|root,336N8@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Caps_assemb_Wzi CMS1_k127_1193510_8 379066.GAU_0743 2.395e-30 139.0 COG4932@1|root,COG4932@2|Bacteria,1ZUFE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M domain protein - - - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - - CMS1_k127_1193510_0 861299.J421_1666 8.134e-81 295.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1208030_2 1300345.LF41_1697 5.085e-131 437.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1X2ZT@135614|Xanthomonadales 135614|Xanthomonadales E Acetylornithine deacetylase Succinyl-diaminopimelate - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS1_k127_1208030_6 485913.Krac_5066 0.000945 43.0 2FCYS@1|root,3451F@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1208030_5 1144275.COCOR_01513 1.315e-19 94.0 COG2050@1|root,COG2050@2|Bacteria,1NNDN@1224|Proteobacteria 1224|Proteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT CMS1_k127_1208030_1 1144275.COCOR_03147 4.075e-138 456.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,4360M@68525|delta/epsilon subdivisions,2X2HZ@28221|Deltaproteobacteria,2Z0WC@29|Myxococcales 28221|Deltaproteobacteria E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS1_k127_1208030_4 1192034.CAP_8837 2.345e-108 382.0 COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,4304Z@68525|delta/epsilon subdivisions,2WVJ8@28221|Deltaproteobacteria,2YV3F@29|Myxococcales 28221|Deltaproteobacteria L Eukaryotic DNA topoisomerase I, catalytic core topI - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_I CMS1_k127_1208030_3 1128421.JAGA01000002_gene1618 1.232e-112 378.0 COG1252@1|root,COG1252@2|Bacteria,2NP3T@2323|unclassified Bacteria 2|Bacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_1208030_0 1379270.AUXF01000002_gene1793 1.218e-264 834.0 COG0480@1|root,COG0480@2|Bacteria,1ZTFA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU CMS1_k127_1234635_4 518766.Rmar_2423 1.871e-58 210.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes 976|Bacteroidetes T PFAM BNR Asp-box repeat - - - - - - - - - - - - Sortilin-Vps10 CMS1_k127_1234635_5 1121271.AUCM01000015_gene2534 2.213e-29 124.0 COG0694@1|root,COG0694@2|Bacteria,1MU8Y@1224|Proteobacteria,2U4HX@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Scaffold protein Nfu/NifU N terminal - - - - - - - - - - - - Nfu_N,NifU CMS1_k127_1234635_0 861299.J421_1395 5.77e-148 487.0 COG2234@1|root,COG2234@2|Bacteria,1ZSXY@142182|Gemmatimonadetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_1234635_2 264201.pc1062 3.75e-76 280.0 COG0318@1|root,COG0318@2|Bacteria,2JFYB@204428|Chlamydiae 204428|Chlamydiae IQ AMP-binding enzyme menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding CMS1_k127_1234635_3 1242864.D187_007605 3.268e-73 257.0 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,42S4J@68525|delta/epsilon subdivisions,2WNH4@28221|Deltaproteobacteria,2YTUZ@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the MenA family. Type 1 subfamily menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA CMS1_k127_1234635_1 1396418.BATQ01000070_gene750 2.772e-124 399.0 COG0447@1|root,COG0447@2|Bacteria,46Z3Z@74201|Verrucomicrobia,2ITPX@203494|Verrucomicrobiae 203494|Verrucomicrobiae H Enoyl-CoA hydratase/isomerase menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_1236138_3 251221.35214024 2.188e-114 380.0 COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria 1117|Cyanobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - - - - - - - - - - SSF CMS1_k127_1236138_5 452637.Oter_2162 9.535e-62 227.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4,6.3.5.5 ko:K01921,ko:K01955 ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502 M00051 R00256,R00575,R01150,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Dala_Dala_lig_C CMS1_k127_1236138_7 861299.J421_4103 4.217e-54 216.0 COG0515@1|root,COG5184@1|root,COG0515@2|Bacteria,COG5184@2|Bacteria,1ZUHN@142182|Gemmatimonadetes 142182|Gemmatimonadetes DKLTZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - Pkinase,RCC1 CMS1_k127_1236138_9 709797.CSIRO_1376 1.01e-10 75.0 2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria,3K0ZR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - CMS1_k127_1236138_0 338969.Rfer_0863 7.501e-243 771.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHII@28216|Betaproteobacteria,4AJXE@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding - - 1.3.99.16 ko:K00256 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 CMS1_k127_1236138_6 338969.Rfer_0864 1.982e-60 214.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VRBT@28216|Betaproteobacteria,4AE1V@80864|Comamonadaceae 28216|Betaproteobacteria C 2Fe-2S -binding domain protein iorA - 1.17.2.1 ko:K18029 ko00760,ko01120,map00760,map01120 M00622 R09473 RC00589 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Fer2_2 CMS1_k127_1236138_4 1047013.AQSP01000097_gene1961 4.968e-62 225.0 COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria 2|Bacteria S Methyltransferase domain mdmC - - - - - - - - - - - Methyltransf_24,Methyltransf_3 CMS1_k127_1236138_2 1047013.AQSP01000105_gene1439 3.537e-151 493.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid MA20_31530 - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS1_k127_1236138_1 313596.RB2501_16209 2.417e-212 671.0 COG1228@1|root,COG1228@2|Bacteria,4NISN@976|Bacteroidetes,1HZDE@117743|Flavobacteriia 976|Bacteroidetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS1_k127_1236138_8 1379270.AUXF01000002_gene1589 6.128e-21 96.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_1264836_12 861299.J421_6213 5.114e-20 90.0 COG5470@1|root,COG5470@2|Bacteria,1ZU5S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF1330) - - - - - - - - - - - - DUF1330 CMS1_k127_1264836_5 1279017.AQYJ01000027_gene1678 1.686e-72 250.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,466D6@72275|Alteromonadaceae 1236|Gammaproteobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA CMS1_k127_1264836_13 941449.dsx2_2375 3.155e-19 102.0 COG0389@1|root,COG0389@2|Bacteria,1NEMK@1224|Proteobacteria,42X8R@68525|delta/epsilon subdivisions,2WRT5@28221|Deltaproteobacteria,2MDJ9@213115|Desulfovibrionales 28221|Deltaproteobacteria L Pathogenicity locus - - - - - - - - - - - - Cdd1 CMS1_k127_1264836_3 1121930.AQXG01000002_gene2362 4.483e-164 532.0 2DBJC@1|root,2Z9K5@2|Bacteria,4P1C2@976|Bacteroidetes,1IWD2@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolase family 47 - - - - - - - - - - - - Glyco_hydro_47 CMS1_k127_1264836_8 643867.Ftrac_2644 1.022e-44 175.0 COG0589@1|root,COG0589@2|Bacteria,4NER9@976|Bacteroidetes,47PF0@768503|Cytophagia 976|Bacteroidetes T Universal stress protein - - - - - - - - - - - - Usp CMS1_k127_1264836_10 1379270.AUXF01000004_gene2933 9.234e-34 140.0 COG2755@1|root,COG2755@2|Bacteria,1ZU6K@142182|Gemmatimonadetes 142182|Gemmatimonadetes E lipolytic protein G-D-S-L family - - - - - - - - - - - - - CMS1_k127_1264836_14 762948.HMPREF0733_10212 1.014e-07 55.0 COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria,1WA3U@1268|Micrococcaceae 201174|Actinobacteria S regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 CMS1_k127_1264836_2 1117318.PRUB_00525 1.269e-193 632.0 COG1506@1|root,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,1RPRK@1236|Gammaproteobacteria,2Q48Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 CMS1_k127_1264836_11 646529.Desaci_2258 1.033e-20 104.0 28ISQ@1|root,33DSE@2|Bacteria,1VQKR@1239|Firmicutes,24WZ0@186801|Clostridia,2662P@186807|Peptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - CMS1_k127_1264836_7 309801.trd_A0609 5.693e-48 181.0 COG2353@1|root,COG2353@2|Bacteria,2G73S@200795|Chloroflexi,27Z4A@189775|Thermomicrobia 189775|Thermomicrobia S YceI-like domain - - - - - - - - - - - - YceI CMS1_k127_1264836_4 861299.J421_0867 9.667e-137 473.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_0867|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1264836_0 690850.Desaf_3768 6.278e-231 736.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2M8CA@213115|Desulfovibrionales 28221|Deltaproteobacteria O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH CMS1_k127_1264836_1 887062.HGR_07006 3.002e-215 677.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria,4AAGV@80864|Comamonadaceae 28216|Betaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 CMS1_k127_1264836_9 1123277.KB893174_gene5986 3.286e-44 179.0 COG0671@1|root,COG0671@2|Bacteria,4NMQW@976|Bacteroidetes,47PHH@768503|Cytophagia 976|Bacteroidetes I Acid phosphatase homologues - - - - - - - - - - - - PAP2 CMS1_k127_1264836_6 945713.IALB_2036 2.398e-59 210.0 COG0205@1|root,COG0205@2|Bacteria 2|Bacteria G 6-phosphofructokinase activity pfp GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 ko:K00850,ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK CMS1_k127_1271673_12 234267.Acid_1768 5.62e-11 70.0 COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria 57723|Acidobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_1271673_10 1121904.ARBP01000052_gene3650 1.544e-20 104.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - ko:K06889 - - - - ko00000 - - - AXE1,Hydrolase_4 CMS1_k127_1271673_0 1379270.AUXF01000002_gene1345 1.404e-138 466.0 COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1271673_6 1453498.LG45_12680 1.316e-40 175.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - - CMS1_k127_1271673_1 357808.RoseRS_1250 6.39e-92 342.0 COG3391@1|root,COG4935@1|root,COG3391@2|Bacteria,COG4935@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - ko:K12287 - - - - ko00000,ko02044 - - - DUF11,P_proprotein,VCBS CMS1_k127_1271673_3 1379270.AUXF01000002_gene1602 3.589e-81 286.0 2CESB@1|root,2Z8UZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1271673_8 861299.J421_2968 2.035e-39 167.0 COG1947@1|root,COG1947@2|Bacteria,1ZTM9@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N CMS1_k127_1271673_5 1379270.AUXF01000005_gene558 5.122e-60 222.0 COG0392@1|root,COG0392@2|Bacteria,1ZT5W@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS1_k127_1271673_11 861299.J421_2970 5.449e-17 95.0 2CB0K@1|root,343GC@2|Bacteria,1ZU4A@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - Hpt CMS1_k127_1271673_2 379066.GAU_1247 4.587e-84 286.0 COG0854@1|root,COG0854@2|Bacteria,1ZSPZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ CMS1_k127_1271673_13 1379270.AUXF01000005_gene561 8.6e-10 66.0 28ZEQ@1|root,2ZM6A@2|Bacteria,1ZU2C@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1271673_7 861299.J421_2973 1.322e-40 153.0 COG0346@1|root,COG0346@2|Bacteria,1ZTMU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 CMS1_k127_1271673_9 861299.J421_2974 3.256e-37 147.0 COG3118@1|root,COG3118@2|Bacteria,1ZTS0@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Thioredoxin-like domain - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin CMS1_k127_1271673_4 1242864.D187_007632 5.97e-62 221.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2WM37@28221|Deltaproteobacteria,2YV9J@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase CMS1_k127_1295553_0 316067.Geob_3570 1.492e-148 479.0 COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Pfam:KaiC - - - ko:K08482 - - - - ko00000 - - - ATPase CMS1_k127_1295553_2 192952.MM_1091 7.282e-33 144.0 COG0526@1|root,arCOG07612@2157|Archaea,2Y43J@28890|Euryarchaeota,2NB18@224756|Methanomicrobia 224756|Methanomicrobia O KaiB - - - ko:K08481 - - - - ko00000 - - - KaiB CMS1_k127_1295553_1 794903.OPIT5_22540 9.976e-60 220.0 COG4585@1|root,COG4585@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07683 ko02020,map02020 M00483 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HATPase_c,HATPase_c_2,HisKA_3,PAS,PAS_4,PAS_9 CMS1_k127_1304035_0 861299.J421_1230 3.019e-159 533.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1304035_1 1232410.KI421416_gene2699 2e-65 229.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,42MQD@68525|delta/epsilon subdivisions,2WJJP@28221|Deltaproteobacteria,43UUZ@69541|Desulfuromonadales 28221|Deltaproteobacteria P Sulfate permease family ychM - 4.2.1.1 ko:K01673,ko:K03321 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000,ko02000 2.A.53.3 - - Pro_CA,STAS,STAS_2,Sulfate_transp CMS1_k127_1307351_0 266117.Rxyl_2411 3.632e-181 580.0 COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria 84995|Rubrobacteria EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B CMS1_k127_1307351_1 222534.KB893670_gene3618 5.629e-153 504.0 COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria 201174|Actinobacteria EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B CMS1_k127_131130_12 626887.J057_12871 3.267e-18 84.0 COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,466G0@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09797 - - - - ko00000 - - - SIMPL CMS1_k127_131130_8 1125863.JAFN01000001_gene1012 1.138e-36 149.0 COG2834@1|root,COG2834@2|Bacteria,1NEDP@1224|Proteobacteria,43117@68525|delta/epsilon subdivisions,2WWFI@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - - CMS1_k127_131130_3 234267.Acid_6770 1.749e-55 219.0 COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,3Y77J@57723|Acidobacteria 57723|Acidobacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - DUF1736,TPR_11,TPR_16 CMS1_k127_131130_9 1499967.BAYZ01000076_gene842 1.282e-36 158.0 COG0457@1|root,COG0457@2|Bacteria,2NQJ6@2323|unclassified Bacteria 2|Bacteria O Tetratricopeptide repeat - - - - - - - - - - - - TPR_2,TPR_8 CMS1_k127_131130_2 880073.Calab_1268 2.33e-58 216.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - NHL,TPR_11 CMS1_k127_131130_10 338969.Rfer_0255 1.029e-26 119.0 COG3303@1|root,COG3303@2|Bacteria,1NX4E@1224|Proteobacteria 1224|Proteobacteria P Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_131130_11 443143.GM18_3675 1.034e-19 100.0 COG3005@1|root,COG3005@2|Bacteria,1NJY9@1224|Proteobacteria,42XJ4@68525|delta/epsilon subdivisions,2WSQ4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 12 heme-binding sites cbcC - - - - - - - - - - - Cytochrome_C7 CMS1_k127_131130_15 1245471.PCA10_26970 0.0002413 52.0 COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1YFCT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Cytochrom_C552,Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_11,TPR_16,TPR_19,TPR_8 CMS1_k127_131130_4 1121438.JNJA01000011_gene1805 9.01e-54 203.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,42MC8@68525|delta/epsilon subdivisions,2WPR0@28221|Deltaproteobacteria,2MBRZ@213115|Desulfovibrionales 28221|Deltaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_131130_5 279238.Saro_3069 2.456e-47 189.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,2U3JJ@28211|Alphaproteobacteria,2K5I8@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_131130_0 1238182.C882_1578 2.406e-139 464.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales 204441|Rhodospirillales E COG0367 Asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS1_k127_131130_1 1173022.Cri9333_3492 1.328e-86 299.0 COG2264@1|root,COG2264@2|Bacteria,1GD45@1117|Cyanobacteria,1HEX6@1150|Oscillatoriales 1117|Cyanobacteria J Ribosomal protein L11 methyltransferase (PrmA) - - - - - - - - - - - - - CMS1_k127_131130_7 289376.THEYE_A0485 5.791e-39 154.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25 CMS1_k127_131130_6 1487923.DP73_04645 2.836e-47 187.0 COG2244@1|root,COG2244@2|Bacteria,1VAKC@1239|Firmicutes,24PMX@186801|Clostridia,2662Q@186807|Peptococcaceae 186801|Clostridia S Membrane protein involved in the export of O-antigen and teichoic acid - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C CMS1_k127_131130_13 290397.Adeh_0632 5.084e-17 85.0 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,43AEY@68525|delta/epsilon subdivisions,2X5UP@28221|Deltaproteobacteria 28221|Deltaproteobacteria S SMART Tetratricopeptide domain protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 CMS1_k127_136432_7 457421.CBFG_03677 5.922e-38 162.0 COG2730@1|root,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process celE1 - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_2,CBM_6,Cellulase,FGE-sulfatase,RicinB_lectin_2 CMS1_k127_136432_3 1121904.ARBP01000017_gene5069 2.288e-73 261.0 2CK9T@1|root,2Z7W9@2|Bacteria,4NH9E@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_136432_9 585531.HMPREF0063_12778 6.078e-20 102.0 COG2242@1|root,COG2242@2|Bacteria,2IGDM@201174|Actinobacteria,4DR5P@85009|Propionibacteriales 201174|Actinobacteria H Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 CMS1_k127_136432_6 1033991.RLEG12_13450 4.495e-42 166.0 COG1216@1|root,COG1216@2|Bacteria,1RDAK@1224|Proteobacteria,2UBKE@28211|Alphaproteobacteria,4BNYQ@82115|Rhizobiaceae 28211|Alphaproteobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_136432_0 1121920.AUAU01000007_gene543 1.208e-173 554.0 COG0604@1|root,COG0604@2|Bacteria,3Y4X4@57723|Acidobacteria 57723|Acidobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_136432_8 1229487.AMYW01000021_gene1729 1.508e-20 100.0 COG4775@1|root,COG4775@2|Bacteria,4NRT9@976|Bacteroidetes,1I4PV@117743|Flavobacteriia,2NYF2@237|Flavobacterium 976|Bacteroidetes M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - CMS1_k127_136432_2 391625.PPSIR1_01062 2.323e-75 267.0 COG2267@1|root,COG2267@2|Bacteria,1RBQF@1224|Proteobacteria 1224|Proteobacteria I alpha/beta hydrolase fold - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 CMS1_k127_136432_11 1382359.JIAL01000001_gene2462 0.0001254 50.0 2EN55@1|root,33FT5@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_136432_4 379066.GAU_3332 9.113e-62 226.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2,DDE_Tnp_1_4 CMS1_k127_136432_10 1121920.AUAU01000005_gene959 1.058e-06 59.0 2E0D8@1|root,32W02@2|Bacteria,3Y5V4@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - CMS1_k127_136432_5 1108045.GORHZ_038_00050 1.011e-53 207.0 COG2021@1|root,COG2021@2|Bacteria 2|Bacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 CMS1_k127_136432_1 861299.J421_1342 1.253e-112 381.0 COG2207@1|root,COG2207@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - HTH_18 CMS1_k127_1403350_11 379066.GAU_0768 9.301e-55 194.0 COG1435@1|root,COG1435@2|Bacteria,1ZTB2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Thymidine kinase tdk - 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK CMS1_k127_1403350_14 379066.GAU_0765 4.296e-45 176.0 COG0237@1|root,COG0237@2|Bacteria,1ZTM2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE CMS1_k127_1403350_13 1379270.AUXF01000004_gene3114 5.006e-50 181.0 COG0509@1|root,COG0509@2|Bacteria,1ZTWD@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H CMS1_k127_1403350_0 861299.J421_2685 0.0 1268.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1ZSUZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P CMS1_k127_1403350_15 861299.J421_2684 1.168e-40 160.0 COG0095@1|root,COG0095@2|Bacteria,1ZTY2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Biotin/lipoate A/B protein ligase family - - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB CMS1_k127_1403350_7 861299.J421_2682 3.946e-87 300.0 COG0601@1|root,COG0601@2|Bacteria,1ZTP1@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS1_k127_1403350_9 861299.J421_2681 1.618e-68 255.0 COG1173@1|root,COG1173@2|Bacteria,1ZTMP@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS1_k127_1403350_6 1379270.AUXF01000004_gene3120 2.946e-92 328.0 COG0444@1|root,COG0444@2|Bacteria,1ZSWI@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY CMS1_k127_1403350_5 1379270.AUXF01000004_gene3121 1.729e-96 344.0 COG4608@1|root,COG4608@2|Bacteria,1ZSTB@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY CMS1_k127_1403350_16 865861.AZSU01000002_gene2787 3.756e-20 101.0 2BDXR@1|root,327MY@2|Bacteria,1UT9P@1239|Firmicutes,2521B@186801|Clostridia,36S1A@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - CMS1_k127_1403350_17 861299.J421_2676 2.216e-14 82.0 2FDPQ@1|root,345QV@2|Bacteria,1ZU3Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1403350_18 342113.DM82_6232 4.022e-12 68.0 COG2331@1|root,COG2331@2|Bacteria,1NMRY@1224|Proteobacteria,2W531@28216|Betaproteobacteria,1KAFV@119060|Burkholderiaceae 28216|Betaproteobacteria S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 CMS1_k127_1403350_8 383372.Rcas_2148 3.221e-81 295.0 COG0745@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg CMS1_k127_1403350_19 272844.PAB2307 2.749e-07 62.0 COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci 183968|Thermococci M GtrA-like protein - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2,GtrA CMS1_k127_1403350_12 861299.J421_2673 6.429e-51 199.0 COG3170@1|root,COG3170@2|Bacteria,1ZTDF@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 CMS1_k127_1403350_10 479434.Sthe_2313 1.648e-57 219.0 COG0665@1|root,COG0665@2|Bacteria,2G6QE@200795|Chloroflexi,27Y6M@189775|Thermomicrobia 189775|Thermomicrobia E NAD(P)-binding Rossmann-like domain - - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO CMS1_k127_1403350_2 861299.J421_2669 7.951e-118 386.0 COG0320@1|root,COG0320@2|Bacteria,1ZTA3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM CMS1_k127_1403350_3 379066.GAU_0750 9.851e-109 372.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 142182|Gemmatimonadetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh CMS1_k127_1403350_1 1379270.AUXF01000004_gene3129 6.644e-160 511.0 COG0022@1|root,COG0022@2|Bacteria,1ZTA8@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C CMS1_k127_1403350_4 671143.DAMO_1596 7.594e-104 351.0 COG0508@1|root,COG0508@2|Bacteria,2NNYD@2323|unclassified Bacteria 2|Bacteria C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) pdhC - 1.2.4.1,2.3.1.12 ko:K00162,ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R02569,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding CMS1_k127_1438143_1 530564.Psta_1991 7.249e-30 121.0 2E5ES@1|root,3306N@2|Bacteria,2J0XS@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS1_k127_1438143_0 247634.GPB2148_1892 1.144e-77 278.0 COG3202@1|root,COG3202@2|Bacteria,1QXXQ@1224|Proteobacteria,1S2KU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TLC ATP/ADP transporter - - - - - - - - - - - - TLC CMS1_k127_1457731_1 861299.J421_1230 6.085e-16 82.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1457731_3 1396141.BATP01000018_gene1546 4.621e-05 50.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - ABM,DUF3225,DUF4440,SnoaL_2,SnoaL_3 CMS1_k127_1457731_0 640513.Entas_3355 3.986e-36 141.0 COG1051@1|root,COG1051@2|Bacteria,1QUA9@1224|Proteobacteria,1T1TY@1236|Gammaproteobacteria,3X2FV@547|Enterobacter 1236|Gammaproteobacteria F Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) nudI - - ko:K12944 - - - - ko00000,ko01000 - - - NUDIX CMS1_k127_1457731_2 861299.J421_1035 1.356e-09 59.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS1_k127_1470904_14 1379270.AUXF01000006_gene308 4.135e-46 169.0 COG4591@1|root,COG4591@2|Bacteria,1ZT1N@142182|Gemmatimonadetes 142182|Gemmatimonadetes M MacB-like periplasmic core domain - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD CMS1_k127_1470904_8 861299.J421_3214 3.118e-74 263.0 COG1136@1|root,COG1136@2|Bacteria,1ZSNF@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Part of the ABC transporter complex LolCDE involved in the translocation of lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran CMS1_k127_1470904_15 379066.GAU_1582 1.303e-35 151.0 COG3880@1|root,COG3880@2|Bacteria,1ZTPQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S UvrB/uvrC motif - - - ko:K19411 - - - - ko00000 - - - UVR CMS1_k127_1470904_4 861299.J421_3216 5.423e-130 435.0 COG3869@1|root,COG3869@2|Bacteria,1ZT9I@142182|Gemmatimonadetes 142182|Gemmatimonadetes F ATP:guanido phosphotransferase, C-terminal catalytic domain - - 2.7.14.1 ko:K19405 - - R11090 RC00002,RC00203 ko00000,ko01000 - - - ATP-gua_Ptrans CMS1_k127_1470904_0 1121468.AUBR01000035_gene1394 1.87e-308 965.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales 186801|Clostridia O Belongs to the ClpA ClpB family clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR CMS1_k127_1470904_1 861299.J421_3218 1.519e-204 667.0 COG4775@1|root,COG4775@2|Bacteria,1ZT6B@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA CMS1_k127_1470904_18 518766.Rmar_1957 2.854e-08 62.0 COG2825@1|root,COG2825@2|Bacteria,4PESF@976|Bacteroidetes,1FJIW@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Outer membrane protein (OmpH-like) - - - ko:K06142 - - - - ko00000 - - - OmpH CMS1_k127_1470904_7 861299.J421_3220 1.734e-75 276.0 COG1044@1|root,COG1044@2|Bacteria,1ZSRF@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,LpxD CMS1_k127_1470904_3 379066.GAU_1588 1.538e-130 429.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,1ZT4Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes IM Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ - 3.5.1.108,4.2.1.59 ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 - - - FabA,LpxC CMS1_k127_1470904_9 379066.GAU_1589 9.472e-71 264.0 COG1043@1|root,COG1043@2|Bacteria,1ZT7T@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep CMS1_k127_1470904_10 1379270.AUXF01000006_gene297 9.099e-65 240.0 COG0763@1|root,COG0763@2|Bacteria,1ZTAD@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB CMS1_k127_1470904_16 861299.J421_3225 8.475e-34 139.0 COG2121@1|root,COG2121@2|Bacteria,1ZTU5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF374) - - - ko:K09778 - - - - ko00000 - - - DUF374 CMS1_k127_1470904_12 861299.J421_3226 7.249e-54 208.0 COG1663@1|root,COG1663@2|Bacteria,1ZTIE@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK CMS1_k127_1470904_2 861299.J421_3227 3.414e-198 645.0 COG0334@1|root,COG0334@2|Bacteria,1ZSQB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_1470904_17 861299.J421_3228 7.825e-30 130.0 COG1576@1|root,COG1576@2|Bacteria,1ZTQJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase CMS1_k127_1470904_13 1329516.JPST01000005_gene1396 1.792e-49 190.0 COG0500@1|root,COG2226@2|Bacteria,1V45D@1239|Firmicutes,4HG4Y@91061|Bacilli,27BS9@186824|Thermoactinomycetaceae 91061|Bacilli Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_25 CMS1_k127_1470904_11 861299.J421_3229 2.728e-64 247.0 COG4365@1|root,COG4365@2|Bacteria,1ZTG0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bacillithiol biosynthesis BshC - - - ko:K22136 - - - - ko00000 - - - BshC CMS1_k127_1470904_5 379066.GAU_1597 2.219e-111 381.0 COG0728@1|root,COG0728@2|Bacteria,1ZTCM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN CMS1_k127_1470904_6 1379270.AUXF01000006_gene290 8.633e-77 284.0 COG0322@1|root,COG0322@2|Bacteria,1ZSXE@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N CMS1_k127_147122_1 1379270.AUXF01000002_gene1589 9.13e-102 335.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_147122_0 1379270.AUXF01000002_gene1600 4.617e-200 655.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_147122_2 1379270.AUXF01000002_gene1600 2.11e-74 273.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_1483152_0 1370122.JHXQ01000019_gene175 2.972e-130 447.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,4B9NS@82115|Rhizobiaceae 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS1_k127_1483152_2 1419583.V466_25595 6.685e-14 83.0 COG0500@1|root,COG2226@2|Bacteria,1PHZD@1224|Proteobacteria,1RVUR@1236|Gammaproteobacteria,1YUEA@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_31 CMS1_k127_1483152_1 247639.MGP2080_08826 7.461e-70 248.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1S00K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA CMS1_k127_1504840_4 521674.Plim_2933 0.0001367 48.0 COG0659@1|root,COG0659@2|Bacteria,2J2QM@203682|Planctomycetes 203682|Planctomycetes P Molybdate transporter of MFS superfamily - - - - - - - - - - - - MFS_MOT1 CMS1_k127_1504840_3 485913.Krac_6570 3.845e-06 55.0 2CCS2@1|root,32VGD@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1504840_1 502025.Hoch_1018 4.76e-23 102.0 COG4973@1|root,COG4973@2|Bacteria,1NY9U@1224|Proteobacteria,432F8@68525|delta/epsilon subdivisions,2WXK7@28221|Deltaproteobacteria,2Z3M7@29|Myxococcales 28221|Deltaproteobacteria L PFAM integrase family protein - - - - - - - - - - - - Phage_integrase CMS1_k127_1504840_0 1298863.AUEP01000009_gene189 4.232e-24 117.0 COG0823@1|root,COG0823@2|Bacteria,2IK6C@201174|Actinobacteria 201174|Actinobacteria U WD40-like Beta Propeller Repeat tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS1_k127_1504840_2 55952.BU52_16815 8.766e-19 100.0 COG3291@1|root,COG3291@2|Bacteria,2GKNE@201174|Actinobacteria 201174|Actinobacteria NU Collagenase - - 3.4.24.3 ko:K01387 - - - - ko00000,ko01000,ko01002,ko02042 - - - PKD,PPC,Peptidase_M9,Peptidase_M9_N CMS1_k127_1526512_8 1382306.JNIM01000001_gene1342 2.513e-21 109.0 COG0337@1|root,COG0337@2|Bacteria,2G5K8@200795|Chloroflexi 200795|Chloroflexi E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI CMS1_k127_1526512_0 861299.J421_3974 1.173e-152 495.0 COG0082@1|root,COG0082@2|Bacteria,1ZT39@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt CMS1_k127_1526512_1 861299.J421_3976 1.732e-137 465.0 COG4796@1|root,COG4796@2|Bacteria,1ZSRT@142182|Gemmatimonadetes 142182|Gemmatimonadetes U AMIN domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,Secretin,Secretin_N CMS1_k127_1526512_11 1379270.AUXF01000003_gene3396 7.312e-12 73.0 COG3167@1|root,COG3167@2|Bacteria,1ZTZ8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Pilus assembly protein, PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO CMS1_k127_1526512_7 1379270.AUXF01000003_gene3395 8.473e-26 115.0 COG3166@1|root,COG3166@2|Bacteria,1ZTR8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Fimbrial assembly protein (PilN) - - - - - - - - - - - - PilN CMS1_k127_1526512_2 379066.GAU_2518 9.046e-124 405.0 COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type IV pilus assembly protein PilM; - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 CMS1_k127_1526512_5 861299.J421_6360 5.17e-38 164.0 2F0M3@1|root,33TPR@2|Bacteria,1ZUAZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1526512_9 861299.J421_6361 3.157e-13 81.0 2F5SD@1|root,33YB8@2|Bacteria,1ZUXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1526512_13 795359.TOPB45_0006 2.059e-05 54.0 COG4970@1|root,COG4970@2|Bacteria,2GI4B@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria NU Tfp pilus assembly protein FimT - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - N_methyl CMS1_k127_1526512_3 1125863.JAFN01000001_gene2900 1.016e-108 374.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_1526512_4 1379270.AUXF01000003_gene3390 5.197e-57 214.0 COG4191@1|root,COG4191@2|Bacteria,1ZSSB@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA CMS1_k127_1526512_6 1379270.AUXF01000002_gene1794 2.492e-31 137.0 2F0M3@1|root,33TPR@2|Bacteria,1ZUAZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1526512_10 1379270.AUXF01000003_gene3669 1.006e-12 80.0 2F5SD@1|root,33YB8@2|Bacteria,1ZUXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1526512_14 861299.J421_6362 9.58e-05 51.0 28RPR@1|root,2ZE2C@2|Bacteria,1ZV82@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - - CMS1_k127_1526512_12 1379270.AUXF01000002_gene1199 4.797e-09 58.0 COG4968@1|root,COG4968@2|Bacteria,1ZTWU@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl CMS1_k127_153242_50 861299.J421_2967 2.38e-48 175.0 COG0462@1|root,COG0462@2|Bacteria,1ZT7Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N CMS1_k127_153242_44 379066.GAU_1218 2.617e-57 207.0 COG1825@1|root,COG1825@2|Bacteria,1ZTHZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance - - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C CMS1_k127_153242_47 379066.GAU_1217 2.645e-52 190.0 COG0193@1|root,COG0193@2|Bacteria,1ZTKT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro CMS1_k127_153242_15 1123277.KB893218_gene6180 1.362e-160 520.0 COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,47KQM@768503|Cytophagia 976|Bacteroidetes G Alpha-L-fucosidase fucA - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos CMS1_k127_153242_12 1123508.JH636446_gene6264 1.663e-233 755.0 COG0823@1|root,COG1262@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1262@2|Bacteria,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity dap2 - 2.7.11.1,3.4.19.1 ko:K01303,ko:K12132 - - - - ko00000,ko01000,ko01001,ko01002 - - - DUF1566,FGE-sulfatase,PD40,Peptidase_S9 CMS1_k127_153242_76 861299.J421_3995 2.5e-24 105.0 2DING@1|root,303QG@2|Bacteria,1ZV8G@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Cysteine-rich CPXCG - - - - - - - - - - - - Cys_rich_CPXG CMS1_k127_153242_5 861299.J421_0584 7.949e-284 888.0 COG0308@1|root,COG0308@2|Bacteria,1ZT68@142182|Gemmatimonadetes 2|Bacteria E aminopeptidase N - - - - - - - - - - - - Peptidase_M1 CMS1_k127_153242_23 861299.J421_0279 4.858e-132 451.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_0279|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_153242_77 1379270.AUXF01000005_gene514 1.146e-23 106.0 COG0360@1|root,COG0360@2|Bacteria,1ZTYY@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 CMS1_k127_153242_79 379066.GAU_1205 6.356e-23 100.0 COG0238@1|root,COG0238@2|Bacteria,1ZU47@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 CMS1_k127_153242_64 1382359.JIAL01000001_gene1373 2.11e-34 139.0 COG0359@1|root,COG0359@2|Bacteria,3Y4MD@57723|Acidobacteria,2JJAN@204432|Acidobacteriia 204432|Acidobacteriia J binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N CMS1_k127_153242_31 883.DvMF_0600 2.507e-85 310.0 COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,42U2G@68525|delta/epsilon subdivisions,2WQBG@28221|Deltaproteobacteria,2M8TG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Dihydroxyacetone kinase family - - - ko:K07030 - - - - ko00000 - - - Dak2,DegV CMS1_k127_153242_65 861299.J421_2949 1.279e-33 149.0 COG0799@1|root,COG0799@2|Bacteria,1ZU0S@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS CMS1_k127_153242_3 861299.J421_2948 8.869e-300 957.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSUS@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - Bac_surface_Ag,PD40 CMS1_k127_153242_78 379066.GAU_1196 1.294e-23 115.0 COG3087@1|root,COG3087@2|Bacteria,1ZSYS@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Sporulation related domain - - - - - - - - - - - - SPOR CMS1_k127_153242_9 861299.J421_2945 8.831e-258 838.0 COG1196@1|root,COG1196@2|Bacteria,1ZSY1@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge CMS1_k127_153242_35 1379698.RBG1_1C00001G1263 1.887e-69 263.0 COG1404@1|root,COG1404@2|Bacteria,2NNSK@2323|unclassified Bacteria 2|Bacteria O Subtilase family aprN - - - - - - - - - - - Peptidase_S8 CMS1_k127_153242_52 379066.GAU_1193 9.908e-44 183.0 2F30N@1|root,33VVY@2|Bacteria,1ZTT9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_153242_34 1379270.AUXF01000005_gene503 6.599e-71 265.0 COG1234@1|root,COG1234@2|Bacteria,1ZT5E@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 CMS1_k127_153242_21 861299.J421_2942 2.433e-139 450.0 COG2876@1|root,COG2876@2|Bacteria,1ZTB0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 CMS1_k127_153242_74 1379270.AUXF01000005_gene501 4.112e-26 123.0 COG2834@1|root,COG2834@2|Bacteria,1ZTXG@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Outer membrane lipoprotein carrier protein LolA - - - ko:K03634 - - - - ko00000 - - - LolA CMS1_k127_153242_36 1242864.D187_006584 1.491e-66 244.0 COG0204@1|root,COG0204@2|Bacteria,1R72B@1224|Proteobacteria 1224|Proteobacteria I COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - - - - - - - - - - Acyltransferase CMS1_k127_153242_66 1443665.JACA01000024_gene3399 4.503e-33 141.0 2ACTN@1|root,312EH@2|Bacteria,4PHCH@976|Bacteroidetes,1II24@117743|Flavobacteriia,2YKJI@290174|Aquimarina 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_153242_18 518766.Rmar_1842 2.865e-148 491.0 COG2270@1|root,COG2270@2|Bacteria,4NEKI@976|Bacteroidetes,1FJQB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S MFS/sugar transport protein - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 CMS1_k127_153242_48 1242864.D187_005009 7.203e-50 187.0 COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria 1224|Proteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) MA20_30510 - - - - - - - - - - - adh_short_C2 CMS1_k127_153242_80 1379270.AUXF01000004_gene2937 3.028e-21 102.0 2E902@1|root,3339H@2|Bacteria,1ZV2W@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_153242_75 1267533.KB906741_gene652 1.855e-24 107.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity ysfE - 2.7.1.49,2.7.4.7,4.2.1.96,4.4.1.5 ko:K00941,ko:K01724,ko:K01759,ko:K07032,ko:K08234 ko00620,ko00730,ko00790,ko01100,map00620,map00730,map00790,map01100 M00127 R02530,R03471,R04509,R04734 RC00002,RC00004,RC00017,RC00740,RC01208 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase CMS1_k127_153242_85 324602.Caur_1629 6.801e-19 99.0 COG0420@1|root,COG0420@2|Bacteria,2G60M@200795|Chloroflexi,3757S@32061|Chloroflexia 32061|Chloroflexia L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos CMS1_k127_153242_92 1121861.KB899926_gene2584 7.834e-12 77.0 COG2010@1|root,COG2010@2|Bacteria,1RBTK@1224|Proteobacteria,2U6ME@28211|Alphaproteobacteria,2JWNK@204441|Rhodospirillales 204441|Rhodospirillales C Cytochrome c - - - - - - - - - - - - - CMS1_k127_153242_46 1303518.CCALI_00307 7.661e-53 202.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c nosZ - 1.1.9.1,1.7.2.4 ko:K00376,ko:K02305,ko:K17760 ko00910,ko01120,map00910,map01120 M00529 R00294,R02804 RC02794,RC02861 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - Beta_helix,Cupredoxin_1,Cytochrom_C,Cytochrome_CBB3,DUF1080,GSDH,HupE_UreJ_2,PSCyt1 CMS1_k127_153242_28 448385.sce1180 2.539e-97 340.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42MPR@68525|delta/epsilon subdivisions,2WNM3@28221|Deltaproteobacteria,2Z06N@29|Myxococcales 28221|Deltaproteobacteria Q Multicopper oxidase - - - ko:K04753 - - - - ko00000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_153242_63 324925.Ppha_0987 3.444e-36 151.0 COG2318@1|root,COG2318@2|Bacteria,1FF75@1090|Chlorobi 1090|Chlorobi S DinB family - - - - - - - - - - - - DinB CMS1_k127_153242_83 479432.Sros_4960 3.149e-20 97.0 COG1249@1|root,COG1249@2|Bacteria,2I5DW@201174|Actinobacteria 201174|Actinobacteria C Alkylmercury lyase - - - - - - - - - - - - MerB CMS1_k127_153242_93 749927.AMED_2325 3.967e-10 63.0 2AAWD@1|root,3109H@2|Bacteria,2IG0D@201174|Actinobacteria,4E8XP@85010|Pseudonocardiales 201174|Actinobacteria S Alkylmercury lyase - - - - - - - - - - - - MerB CMS1_k127_153242_26 926556.Echvi_0939 3.936e-119 407.0 COG0613@1|root,COG0613@2|Bacteria,4PMKK@976|Bacteroidetes,47NYR@768503|Cytophagia 976|Bacteroidetes S PHP domain protein - - - - - - - - - - - - - CMS1_k127_153242_97 1385515.N791_12625 0.0002231 46.0 COG1595@1|root,COG1595@2|Bacteria,1N3BR@1224|Proteobacteria,1SCCR@1236|Gammaproteobacteria,1X7D3@135614|Xanthomonadales 135614|Xanthomonadales K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF CMS1_k127_153242_82 1089550.ATTH01000001_gene2237 1.348e-20 94.0 COG1595@1|root,COG1595@2|Bacteria,4NSN4@976|Bacteroidetes 976|Bacteroidetes K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF CMS1_k127_153242_27 861299.J421_1760 4.133e-101 363.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_153242_61 697282.Mettu_2125 1.233e-37 151.0 COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,1S9PQ@1236|Gammaproteobacteria,1XFRK@135618|Methylococcales 135618|Methylococcales S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 CMS1_k127_153242_10 322710.Avin_20870 3.075e-241 765.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_7 CMS1_k127_153242_19 748247.AZKH_0459 3.671e-145 495.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,2KVD6@206389|Rhodocyclales 206389|Rhodocyclales S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - CMS1_k127_153242_84 713586.KB900536_gene2398 5.138e-20 101.0 COG1977@1|root,COG1977@2|Bacteria,1N9QE@1224|Proteobacteria 1224|Proteobacteria H ThiS family - - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS CMS1_k127_153242_43 290397.Adeh_0590 2.801e-58 224.0 COG3391@1|root,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria 1224|Proteobacteria M 6-phosphogluconolactonase activity - - - - - - - - - - - - ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS CMS1_k127_153242_33 926562.Oweho_0067 6.173e-78 289.0 28HH2@1|root,2Z7ST@2|Bacteria,4NMWR@976|Bacteroidetes,1I1Q4@117743|Flavobacteriia 976|Bacteroidetes M Thiol-activated cytolysin - - - ko:K11031 ko02024,map02024 - - - ko00000,ko00001,ko02042 - - - Thiol_cytolysin CMS1_k127_153242_49 1265502.KB905935_gene3090 1.913e-49 192.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2VKCK@28216|Betaproteobacteria,4AB53@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mdtA_2 - - ko:K03585,ko:K18306 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,2.A.6.2.20,2.A.6.2.32,8.A.1,8.A.1.6 - - HlyD_D23 CMS1_k127_153242_68 215803.DB30_3564 2.748e-32 148.0 COG1538@1|root,COG1538@2|Bacteria,1Q54P@1224|Proteobacteria,42NQV@68525|delta/epsilon subdivisions,2X5KQ@28221|Deltaproteobacteria,2YYUS@29|Myxococcales 28221|Deltaproteobacteria M Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS1_k127_153242_4 1379698.RBG1_1C00001G1725 7.205e-289 919.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran CMS1_k127_153242_41 1500301.JQMF01000026_gene3036 2.2e-59 211.0 COG0789@1|root,COG0789@2|Bacteria,1RH2U@1224|Proteobacteria,2VA8A@28211|Alphaproteobacteria,4BE5A@82115|Rhizobiaceae 28211|Alphaproteobacteria K helix_turn_helix, mercury resistance - - - ko:K13639 - - - - ko00000,ko03000 - - - MerR,MerR-DNA-bind CMS1_k127_153242_67 379066.GAU_0210 1.024e-32 136.0 COG0640@1|root,COG0640@2|Bacteria,1ZV8Z@142182|Gemmatimonadetes 2|Bacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11 CMS1_k127_153242_95 326424.FRAAL2823 1.095e-07 64.0 COG3832@1|root,COG3832@2|Bacteria,2H75S@201174|Actinobacteria 201174|Actinobacteria S Activator of hsp90 atpase 1 family protein - - - - - - - - - - - - AHSA1 CMS1_k127_153242_58 379066.GAU_0209 6.948e-41 166.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - - - - - - - - - - - AHSA1 CMS1_k127_153242_53 909663.KI867150_gene69 1.224e-43 166.0 arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_153242_69 1500893.JQNB01000001_gene2171 1.745e-30 125.0 COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,1SYIJ@1236|Gammaproteobacteria,1X7E5@135614|Xanthomonadales 135614|Xanthomonadales K helix_turn_helix, mercury resistance - - - ko:K19591 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 CMS1_k127_153242_25 1173026.Glo7428_1703 1.283e-119 394.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1G0MX@1117|Cyanobacteria 1117|Cyanobacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N CMS1_k127_153242_6 1283299.AUKG01000002_gene3678 5.512e-277 886.0 COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4CP7U@84995|Rubrobacteria 84995|Rubrobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 CMS1_k127_153242_7 1078020.KEK_21674 6.94e-268 844.0 COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,23324@1762|Mycobacteriaceae 201174|Actinobacteria G Belongs to the glycosyl hydrolase 13 family glgX_1 - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 CMS1_k127_153242_1 309801.trd_1931 0.0 1374.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia 189775|Thermomicrobia G Alpha-amylase domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C CMS1_k127_153242_8 861299.J421_3816 5.532e-258 820.0 COG0366@1|root,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 CMS1_k127_153242_14 69279.BG36_04310 2.606e-171 555.0 COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,43IDV@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim,Reductase_C,Rieske CMS1_k127_153242_42 1210884.HG799465_gene11339 2.024e-58 208.0 COG0262@1|root,COG0262@2|Bacteria,2J1IB@203682|Planctomycetes 203682|Planctomycetes H RibD C-terminal domain - - - - - - - - - - - - RibD_C CMS1_k127_153242_56 861299.J421_0408 2.326e-41 168.0 2E3MN@1|root,32NV6@2|Bacteria,1ZV65@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 CMS1_k127_153242_0 1379270.AUXF01000005_gene641 0.0 1448.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes 2|Bacteria O Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1 CMS1_k127_153242_57 926560.KE387023_gene2407 3.788e-41 157.0 COG1832@1|root,COG1832@2|Bacteria 2|Bacteria S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 CMS1_k127_153242_60 861299.J421_1117 2.37e-40 166.0 COG0613@1|root,COG0613@2|Bacteria,1ZV9V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S PHP domain protein - - - - - - - - - - - - - CMS1_k127_153242_40 189753.AXAS01000021_gene1820 9.325e-63 243.0 COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria,3JT7A@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_153242_13 1210884.HG799465_gene11386 8.651e-180 579.0 COG4948@1|root,COG4948@2|Bacteria,2IY85@203682|Planctomycetes 203682|Planctomycetes M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - 4.2.1.171 ko:K21624 ko00330,map00330 - R11625 - ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N CMS1_k127_153242_24 861299.J421_0468 1.668e-122 432.0 COG0515@1|root,COG0515@2|Bacteria,1ZUHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_153242_17 1122611.KB903939_gene313 6.086e-155 520.0 COG0515@1|root,COG4403@1|root,COG0515@2|Bacteria,COG4403@2|Bacteria,2H5BJ@201174|Actinobacteria 201174|Actinobacteria KLT Lanthionine synthetase C-like protein - - - - - - - - - - - - LANC_like CMS1_k127_153242_54 1122611.KB903939_gene312 5.023e-42 169.0 28QBS@1|root,2ZCUB@2|Bacteria,2HBTV@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_153242_29 1379270.AUXF01000002_gene1306 2.279e-87 310.0 COG1680@1|root,COG1680@2|Bacteria,1ZU44@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_153242_87 1122128.AUEE01000010_gene1566 2.482e-15 79.0 2EGKD@1|root,33ACM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_153242_91 1047013.AQSP01000131_gene1807 2.375e-14 81.0 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - - - - - - - - - - - DUF1295,PEMT CMS1_k127_153242_59 1267535.KB906767_gene4681 9.871e-41 164.0 COG0262@1|root,COG0262@2|Bacteria 2|Bacteria H dihydrofolate reductase activity - - - - - - - - - - - - RibD_C CMS1_k127_153242_11 861299.J421_1048 1.169e-235 762.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS1_k127_153242_90 1120936.KB907221_gene2189 2.073e-14 79.0 2EHX5@1|root,33BNR@2|Bacteria,2GPW7@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_153242_72 1386089.N865_03330 8.178e-29 119.0 COG1765@1|root,COG1765@2|Bacteria,2IFY4@201174|Actinobacteria 201174|Actinobacteria O PFAM OsmC family protein - - - - - - - - - - - - OsmC CMS1_k127_153242_62 743974.MBO_06259 2.568e-37 144.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,3NNP2@468|Moraxellaceae 1236|Gammaproteobacteria O Belongs to the thioredoxin family trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - iECW_1372.ECW_m4079,iECs_1301.ECs4714,iEKO11_1354.EKO11_4576,iG2583_1286.G2583_4574,iSBO_1134.SBO_3791,iSDY_1059.SDY_3968,iSF_1195.SF3854,iSSON_1240.SSON_3952,iS_1188.S3905,iWFL_1372.ECW_m4079,iZ_1308.Z5291 Thioredoxin CMS1_k127_153242_30 1121468.AUBR01000001_gene574 4.374e-87 297.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,42J26@68295|Thermoanaerobacterales 186801|Clostridia C 4Fe-4S single cluster domain csdA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4,Fer4_12,Radical_SAM CMS1_k127_153242_2 1121422.AUMW01000009_gene3340 0.0 1097.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2618A@186807|Peptococcaceae 186801|Clostridia C Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde - - 2.3.1.54,4.3.99.4 ko:K00656,ko:K20038 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like CMS1_k127_153242_38 1121878.AUGL01000022_gene3713 3.651e-64 236.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria 1236|Gammaproteobacteria T permease tqsA GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944 - ko:K11744 - - - - ko00000 - - - AI-2E_transport CMS1_k127_153242_89 1122604.JONR01000061_gene2113 7.984e-15 83.0 COG4319@1|root,COG4319@2|Bacteria,1PZUH@1224|Proteobacteria,1SUHF@1236|Gammaproteobacteria,1XBQN@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 CMS1_k127_153242_71 626939.HMPREF9443_01483 3.463e-29 134.0 COG5495@1|root,COG5495@2|Bacteria,1UZZU@1239|Firmicutes,4H47T@909932|Negativicutes 909932|Negativicutes S Domain of unknown function (DUF2520) - - - - - - - - - - - - DUF2520,F420_oxidored,Rossmann-like CMS1_k127_153242_20 861299.J421_2940 1.532e-139 466.0 COG0793@1|root,COG0793@2|Bacteria,1ZSUF@142182|Gemmatimonadetes 142182|Gemmatimonadetes M tail specific protease - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,Peptidase_S41 CMS1_k127_153242_55 1121377.KB906404_gene2906 5.1e-42 168.0 COG0125@1|root,COG0125@2|Bacteria,1WK3U@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin CMS1_k127_153242_81 861299.J421_2938 3.689e-21 100.0 COG3679@1|root,COG3679@2|Bacteria,1ZTRW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Control of competence regulator ComK, YlbF/YmcA - - - - - - - - - - - - Com_YlbF CMS1_k127_153242_45 861299.J421_2937 7.213e-53 207.0 COG2890@1|root,COG2890@2|Bacteria,1ZTQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Methyltransferase small domain - - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS CMS1_k127_153242_22 861299.J421_2936 4.86e-138 447.0 COG0216@1|root,COG0216@2|Bacteria,1ZSNT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 CMS1_k127_153242_73 411471.SUBVAR_05136 2.486e-26 113.0 COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3WKI1@541000|Ruminococcaceae 186801|Clostridia J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 CMS1_k127_153242_37 861299.J421_2935 4.979e-65 229.0 COG0664@1|root,COG0664@2|Bacteria,1ZTHA@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, cAMP Regulatory protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding CMS1_k127_153242_39 1496688.ER33_11280 5.28e-63 226.0 COG1235@1|root,COG2199@1|root,COG2203@1|root,COG1235@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1G1UR@1117|Cyanobacteria,22TIW@167375|Cyanobium 1117|Cyanobacteria T Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 CMS1_k127_153242_94 103690.17132440 2.612e-09 66.0 COG1462@1|root,COG1462@2|Bacteria,1G2XT@1117|Cyanobacteria,1HPMP@1161|Nostocales 1117|Cyanobacteria M PFAM Curli production assembly transport component CsgG - - - - - - - - - - - - CsgG CMS1_k127_153242_70 1121920.AUAU01000009_gene1874 2.387e-30 132.0 COG0767@1|root,COG0767@2|Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS1_k127_153242_88 1123377.AUIV01000006_gene1536 3.285e-15 89.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1X3PT@135614|Xanthomonadales 135614|Xanthomonadales Q abc transporter atp-binding protein - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran CMS1_k127_153242_96 497964.CfE428DRAFT_0102 4.918e-06 58.0 COG1463@1|root,COG1463@2|Bacteria,46T81@74201|Verrucomicrobia 74201|Verrucomicrobia Q MlaD protein ttg2C - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS1_k127_153242_16 204669.Acid345_4432 4.25e-160 539.0 COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,3Y61X@57723|Acidobacteria 57723|Acidobacteria T HD domain - - - - - - - - - - - - GAF,HD_5 CMS1_k127_153242_32 861299.J421_6309 1.083e-81 292.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6309|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1569498_45 861299.J421_2118 7.912e-31 131.0 COG5549@1|root,COG5549@2|Bacteria,1ZTQC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Matrixin - - - - - - - - - - - - Peptidase_M10 CMS1_k127_1569498_16 118166.JH976537_gene1005 4.884e-99 351.0 COG2409@1|root,COG2409@2|Bacteria 2|Bacteria D Drug exporters of the RND superfamily ydfJ - - ko:K06994,ko:K07003 - - - - ko00000 - - - MMPL CMS1_k127_1569498_62 345341.KUTG_03620 1.183e-05 58.0 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - - - - - - - - - - PQQ_2,PQQ_3 CMS1_k127_1569498_50 1379270.AUXF01000002_gene1200 2.651e-21 109.0 2CIIM@1|root,348GD@2|Bacteria,1ZU31@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1569498_0 861299.J421_1151 1.881e-294 930.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1ZTCF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 CMS1_k127_1569498_48 861299.J421_1150 1.987e-22 98.0 COG1278@1|root,COG1278@2|Bacteria 2|Bacteria K Cold shock cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS1_k127_1569498_59 861299.J421_1149 1.994e-07 64.0 COG0170@1|root,COG0170@2|Bacteria 2|Bacteria I dolichyl monophosphate biosynthetic process sec59 - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf CMS1_k127_1569498_43 861299.J421_1054 3.58e-33 149.0 COG0741@1|root,COG0741@2|Bacteria 2|Bacteria M lytic transglycosylase activity slt GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 iETEC_1333.ETEC_4747,iPC815.YPO0452 SLT,SLT_L CMS1_k127_1569498_23 379066.GAU_0009 7.307e-73 263.0 2DTII@1|root,33KI8@2|Bacteria,1ZT3J@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1569498_19 1379270.AUXF01000002_gene1196 3.296e-96 325.0 COG0515@1|root,COG0515@2|Bacteria,1ZT9E@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1569498_34 1379270.AUXF01000002_gene1195 2.844e-52 197.0 COG0461@1|root,COG0461@2|Bacteria,1ZTMR@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran CMS1_k127_1569498_33 861299.J421_1142 1.576e-53 205.0 COG2207@1|root,COG2207@2|Bacteria,1ZTPX@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 CMS1_k127_1569498_55 34506.g3068 7.2e-17 84.0 2D1ZE@1|root,2SJVP@2759|Eukaryota,3AI9D@33154|Opisthokonta,3BX0X@33208|Metazoa,3DEMU@33213|Bilateria 33208|Metazoa S LppC putative lipoprotein - - - - - - - - - - - - LppC CMS1_k127_1569498_9 861299.J421_1072 8.888e-172 545.0 COG0592@1|root,COG0592@2|Bacteria,1ZT22@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_3 CMS1_k127_1569498_8 379066.GAU_0001 6.614e-174 557.0 COG0593@1|root,COG0593@2|Bacteria,1ZSQ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N CMS1_k127_1569498_54 861299.J421_1070 4.601e-17 81.0 COG0230@1|root,COG0230@2|Bacteria,1ZU59@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L34 rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 CMS1_k127_1569498_47 525909.Afer_2036 1.899e-22 104.0 COG0759@1|root,COG0759@2|Bacteria,2HH1R@201174|Actinobacteria,4CP20@84992|Acidimicrobiia 84992|Acidimicrobiia S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic CMS1_k127_1569498_10 1379270.AUXF01000002_gene1186 8.456e-127 428.0 COG0706@1|root,COG0706@2|Bacteria,1ZSKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas CMS1_k127_1569498_15 379066.GAU_3931 6.544e-103 350.0 COG0486@1|root,COG0486@2|Bacteria,1ZSRA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N CMS1_k127_1569498_14 1379270.AUXF01000002_gene1184 8.1e-104 346.0 COG5504@1|root,COG5504@2|Bacteria,1ZTCN@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Zn-dependent protease - - - - - - - - - - - - - CMS1_k127_1569498_63 518766.Rmar_2301 2.724e-05 57.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_2301|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_1569498_36 504728.K649_06990 1.165e-48 178.0 COG2110@1|root,COG2110@2|Bacteria,1WJ1P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - - - - - - - - - - Macro CMS1_k127_1569498_46 861299.J421_0895 6.743e-28 126.0 COG0705@1|root,COG0705@2|Bacteria,1ZSWV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Rhomboid family - - - - - - - - - - - - Rhomboid CMS1_k127_1569498_17 349521.HCH_06188 2.022e-98 336.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1XHNJ@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N CMS1_k127_1569498_53 713586.KB900536_gene2893 4.355e-19 101.0 COG0720@1|root,COG0720@2|Bacteria,1PNDM@1224|Proteobacteria,1S7ZW@1236|Gammaproteobacteria,1WZ30@135613|Chromatiales 135613|Chromatiales H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS CMS1_k127_1569498_7 861299.J421_0897 3.789e-189 608.0 COG0031@1|root,COG0031@2|Bacteria,1ZTA6@142182|Gemmatimonadetes 142182|Gemmatimonadetes EK Domain in cystathionine beta-synthase and other proteins. - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP CMS1_k127_1569498_49 1379270.AUXF01000002_gene1159 2.387e-21 107.0 COG0810@1|root,COG0810@2|Bacteria,1ZV4A@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C CMS1_k127_1569498_2 1125863.JAFN01000001_gene2068 2.912e-226 734.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria 28221|Deltaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V CMS1_k127_1569498_52 861299.J421_0904 7.645e-20 100.0 COG1729@1|root,COG3087@1|root,COG1729@2|Bacteria,COG3087@2|Bacteria,1ZTSZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Sporulation related domain - - - - - - - - - - - - SPOR,TPR_6 CMS1_k127_1569498_32 379066.GAU_3913 6.274e-54 206.0 COG1466@1|root,COG1466@2|Bacteria,1ZSSZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta CMS1_k127_1569498_21 861299.J421_0907 2.918e-85 292.0 COG1595@1|root,COG1595@2|Bacteria,1ZT2V@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_1569498_28 1379270.AUXF01000002_gene1169 1.399e-58 210.0 COG0494@1|root,COG0494@2|Bacteria,1ZTQ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX CMS1_k127_1569498_20 379066.GAU_3928 5.226e-87 299.0 COG0035@1|root,COG0035@2|Bacteria,1ZT1C@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase CMS1_k127_1569498_51 1111479.AXAR01000007_gene946 2.254e-20 104.0 COG1232@1|root,COG1232@2|Bacteria,1TQ6W@1239|Firmicutes,4HAUG@91061|Bacilli 91061|Bacilli H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS09325 Amino_oxidase CMS1_k127_1569498_13 861299.J421_0468 7.796e-122 428.0 COG0515@1|root,COG0515@2|Bacteria,1ZUHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1569498_11 861299.J421_5836 1.973e-125 430.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1569498_1 215803.DB30_4063 8.165e-248 776.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,42PGV@68525|delta/epsilon subdivisions,2WIS0@28221|Deltaproteobacteria,2YZVC@29|Myxococcales 28221|Deltaproteobacteria Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 CMS1_k127_1569498_6 861299.J421_0271 6.128e-194 622.0 COG4585@1|root,COG4585@2|Bacteria,1ZSM2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Histidine kinase - - - - - - - - - - - - HisKA_3 CMS1_k127_1569498_26 861299.J421_0272 2.224e-60 218.0 COG2197@1|root,COG2197@2|Bacteria,1ZTJ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg CMS1_k127_1569498_3 1304284.L21TH_0179 1.669e-217 688.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36HQZ@31979|Clostridiaceae 186801|Clostridia C Aldehyde dehydrogenase family rocA - 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh,Pro_dh CMS1_k127_1569498_25 1123242.JH636438_gene5687 8.983e-65 234.0 COG0109@1|root,COG0109@2|Bacteria,2IYUU@203682|Planctomycetes 203682|Planctomycetes O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA CMS1_k127_1569498_12 861299.J421_0465 1.63e-124 410.0 COG0823@1|root,COG0823@2|Bacteria,1ZTFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS1_k127_1569498_24 861299.J421_2921 7.069e-67 243.0 COG0681@1|root,COG0681@2|Bacteria,1ZTQ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 CMS1_k127_1569498_30 861299.J421_2921 5.279e-56 204.0 COG0681@1|root,COG0681@2|Bacteria,1ZTQ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 CMS1_k127_1569498_37 861299.J421_2405 2.874e-44 181.0 COG0840@1|root,COG0840@2|Bacteria,1ZSWC@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal CMS1_k127_1569498_38 1379270.AUXF01000002_gene1824 8.743e-44 178.0 COG0683@1|root,COG0683@2|Bacteria,1ZSQF@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 CMS1_k127_1569498_22 864051.BurJ1DRAFT_3799 3.149e-79 285.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,2W5VT@28216|Betaproteobacteria 28216|Betaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase CMS1_k127_1569498_27 266117.Rxyl_0345 2.402e-59 218.0 COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CQF1@84995|Rubrobacteria 84995|Rubrobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 CMS1_k127_1569498_35 521045.Kole_1143 6.222e-49 186.0 COG1704@1|root,COG1704@2|Bacteria,2GCV5@200918|Thermotogae 200918|Thermotogae S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA CMS1_k127_1569498_40 379066.GAU_0196 7.985e-37 146.0 COG0789@1|root,COG0789@2|Bacteria,1ZTHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes K MerR HTH family regulatory protein - - - - - - - - - - - - MerR_1 CMS1_k127_1569498_57 861299.J421_4437 3.547e-12 78.0 COG4970@1|root,COG4970@2|Bacteria,1ZU5N@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Tfp pilus assembly protein FimT - - - - - - - - - - - - - CMS1_k127_1569498_44 861299.J421_0446 1.144e-31 136.0 2F3M0@1|root,33WE8@2|Bacteria,1ZTTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1569498_5 861299.J421_0444 1.06e-194 617.0 COG0174@1|root,COG0174@2|Bacteria,1ZSYQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glutamine synthetase, beta-Grasp domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N CMS1_k127_1569498_29 1267535.KB906767_gene1343 1.121e-56 204.0 COG2085@1|root,COG2085@2|Bacteria,3Y5CN@57723|Acidobacteria,2JNMR@204432|Acidobacteriia 204432|Acidobacteriia S NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored CMS1_k127_1569498_56 498211.CJA_2625 1.142e-14 87.0 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria,1FGVX@10|Cellvibrio 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB CMS1_k127_1569498_39 1123399.AQVE01000022_gene386 2.478e-39 154.0 COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0145 family ybjQ - - - - - - - - - - - YbjQ_1 CMS1_k127_1569498_4 649638.Trad_2672 2.277e-197 644.0 COG0475@1|root,COG0589@1|root,COG1762@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,COG1762@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system napA - 2.1.1.163,2.1.1.201,2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K03183 ko00051,ko00130,ko01100,ko01110,ko01120,ko02060,map00051,map00130,map01100,map01110,map01120,map02060 M00116,M00117,M00273 R03232,R04990,R04993,R06859,R08774,R09736 RC00003,RC00017,RC01253,RC01662,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - Na_H_Exchanger,Usp CMS1_k127_1569498_18 575540.Isop_1666 4.789e-97 338.0 COG0793@1|root,COG0793@2|Bacteria 2|Bacteria M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S41,Tricorn_C1 CMS1_k127_1569498_41 379066.GAU_1101 9.055e-37 149.0 COG2834@1|root,COG2834@2|Bacteria,1ZUW4@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - - CMS1_k127_1569498_31 1379270.AUXF01000005_gene674 3.987e-55 222.0 COG0457@1|root,COG0457@2|Bacteria,1ZSPN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388,TPR_16,TPR_2 CMS1_k127_1569498_42 1121104.AQXH01000002_gene595 7.826e-35 154.0 COG3188@1|root,COG3188@2|Bacteria,4NFPY@976|Bacteroidetes 976|Bacteroidetes NU N-Acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - - CMS1_k127_1569498_58 314225.ELI_10115 2.129e-08 66.0 COG3121@1|root,COG3121@2|Bacteria,1RFSJ@1224|Proteobacteria,2U926@28211|Alphaproteobacteria,2KBG1@204457|Sphingomonadales 204457|Sphingomonadales NU COG3121 P pilus assembly protein, chaperone PapD - - - - - - - - - - - - - CMS1_k127_1572506_1 700598.Niako_6295 5.413e-133 433.0 COG2159@1|root,COG2159@2|Bacteria,4NG9U@976|Bacteroidetes,1IWYY@117747|Sphingobacteriia 976|Bacteroidetes S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 CMS1_k127_1572506_0 234267.Acid_2282 1.907e-204 650.0 COG1228@1|root,COG1228@2|Bacteria,3Y3PQ@57723|Acidobacteria 57723|Acidobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS1_k127_1621294_1 234267.Acid_3557 1.064e-117 390.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Abhydrolase_6 CMS1_k127_1621294_17 1470593.BW43_02446 7.072e-13 76.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 CMS1_k127_1621294_10 765869.BDW_04600 4.094e-29 123.0 COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,430NN@68525|delta/epsilon subdivisions,2MT6T@213481|Bdellovibrionales,2WVYS@28221|Deltaproteobacteria 213481|Bdellovibrionales B SWI complex, BAF60b domains - - - - - - - - - - - - SWIB CMS1_k127_1621294_8 479434.Sthe_0472 3.632e-50 190.0 COG0164@1|root,COG0164@2|Bacteria,2G6KR@200795|Chloroflexi,27YAF@189775|Thermomicrobia 189775|Thermomicrobia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII CMS1_k127_1621294_9 861299.J421_3822 8.32e-44 164.0 COG0335@1|root,COG0335@2|Bacteria,1ZTUC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 CMS1_k127_1621294_2 861299.J421_3824 3.893e-86 294.0 COG0336@1|root,COG0336@2|Bacteria,1ZT8K@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT CMS1_k127_1621294_12 928724.SacglDRAFT_01064 4.905e-23 107.0 COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4E2W5@85010|Pseudonocardiales 201174|Actinobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM GO:0008150,GO:0040007 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM CMS1_k127_1621294_11 335541.Swol_1497 1.273e-23 103.0 COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,42K3P@68298|Syntrophomonadaceae 186801|Clostridia J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 CMS1_k127_1621294_0 1379270.AUXF01000003_gene3580 7.736e-154 497.0 COG0541@1|root,COG0541@2|Bacteria,1ZSPG@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB CMS1_k127_1621294_13 522772.Dacet_1568 1.466e-20 106.0 COG4399@1|root,COG4399@2|Bacteria,2GER8@200930|Deferribacteres 200930|Deferribacteres S Protein of unknown function (DUF445) - - - - - - - - - - - - DUF445 CMS1_k127_1621294_4 379066.GAU_2350 8.547e-72 258.0 COG2856@1|root,COG2856@2|Bacteria,1ZSXU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zn peptidase - - - - - - - - - - - - - CMS1_k127_1621294_16 1047013.AQSP01000139_gene2325 1.543e-14 85.0 COG3595@1|root,COG3595@2|Bacteria,2NQ1F@2323|unclassified Bacteria 2|Bacteria S Putative adhesin - - - - - - - - - - - - DUF4097 CMS1_k127_1621294_14 1163407.UU7_09270 4.973e-20 100.0 COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales 135614|Xanthomonadales S Putative adhesin - - - - - - - - - - - - DUF4097 CMS1_k127_1621294_15 1379270.AUXF01000001_gene2633 4.886e-18 94.0 2F756@1|root,33ZKP@2|Bacteria,1ZU38@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1621294_7 379066.GAU_2723 2.884e-51 188.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_1621294_5 379066.GAU_2351 8.514e-59 213.0 COG1989@1|root,COG1989@2|Bacteria,1ZT9K@142182|Gemmatimonadetes 142182|Gemmatimonadetes NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 CMS1_k127_1621294_6 861299.J421_3833 2.848e-51 196.0 COG0566@1|root,COG0566@2|Bacteria,1ZTVA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J RNA 2'-O ribose methyltransferase substrate binding - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind CMS1_k127_1621294_3 1330700.JQNC01000001_gene2179 2.563e-73 267.0 COG0351@1|root,COG0351@2|Bacteria,1WIN0@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin CMS1_k127_162948_0 1519464.HY22_09770 5.453e-33 141.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - UPF0164 CMS1_k127_164040_3 1267535.KB906767_gene2749 5.696e-102 338.0 COG3620@1|root,COG3620@2|Bacteria,3Y6X6@57723|Acidobacteria 57723|Acidobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 CMS1_k127_164040_2 1123277.KB893180_gene2483 8.771e-180 586.0 COG3975@1|root,COG3975@2|Bacteria,4NE4D@976|Bacteroidetes,47NWB@768503|Cytophagia 976|Bacteroidetes S M61 glycyl aminopeptidase - - - - - - - - - - - - PDZ_2,Peptidase_M61 CMS1_k127_164040_5 1192034.CAP_8220 2.018e-61 224.0 COG4714@1|root,COG4714@2|Bacteria,1N40I@1224|Proteobacteria,434T4@68525|delta/epsilon subdivisions,2WZ46@28221|Deltaproteobacteria,2Z1A5@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF2167) - - - - - - - - - - - - DUF2167 CMS1_k127_164040_0 113395.AXAI01000053_gene2640 1.449e-315 1004.0 COG0507@1|root,COG1112@1|root,COG2251@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,COG2251@2|Bacteria,1MWW9@1224|Proteobacteria,2TTSD@28211|Alphaproteobacteria,3JQNN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L AAA domain - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,RNase_H_2 CMS1_k127_164040_4 1379270.AUXF01000002_gene1756 1.005e-65 244.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA CMS1_k127_164040_6 1379270.AUXF01000007_gene1064 3.897e-38 161.0 COG2378@1|root,COG2378@2|Bacteria 2|Bacteria K regulation of single-species biofilm formation - - - ko:K13572,ko:K13573 - - - - ko00000,ko03051 - - - WYL CMS1_k127_164040_7 1041522.MCOL_V207765 2.129e-17 94.0 COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,233Q7@1762|Mycobacteriaceae 201174|Actinobacteria K WYL domain pafC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - ko:K13573 - - - - ko00000,ko03051 - - - WYL CMS1_k127_164040_1 1267533.KB906737_gene1841 2.057e-243 770.0 COG0367@1|root,COG0367@2|Bacteria 2|Bacteria E asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS1_k127_168667_7 1382306.JNIM01000001_gene1964 8.778e-32 138.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine ycbU - - - - - - - - - - - Aminotran_5 CMS1_k127_168667_8 861299.J421_2311 3.298e-28 119.0 2FKCY@1|root,34C0C@2|Bacteria,1ZU3I@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_168667_3 1128421.JAGA01000001_gene2365 8.262e-70 253.0 COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria 2|Bacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 CMS1_k127_168667_6 246197.MXAN_0010 1.324e-45 183.0 COG2843@1|root,COG2843@2|Bacteria,1Q4SV@1224|Proteobacteria,42ZT3@68525|delta/epsilon subdivisions,2WV46@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - - - - - - - - - - PGA_cap CMS1_k127_168667_4 497964.CfE428DRAFT_0749 2.118e-65 233.0 COG0327@1|root,COG0327@2|Bacteria 2|Bacteria L Belongs to the GTP cyclohydrolase I type 2 NIF3 family ybgI GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - NIF3 CMS1_k127_168667_12 1121104.AQXH01000001_gene1344 2.757e-10 72.0 COG1664@1|root,COG1664@2|Bacteria,4NUZA@976|Bacteroidetes,1IU1I@117747|Sphingobacteriia 976|Bacteroidetes M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin CMS1_k127_168667_9 498848.TaqDRAFT_4817 2.436e-25 117.0 COG0739@1|root,COG0739@2|Bacteria,1WIP1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 CMS1_k127_168667_5 867903.ThesuDRAFT_00478 4.648e-65 241.0 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,3WCHW@538999|Clostridiales incertae sedis 186801|Clostridia K Belongs to the ParB family spo0J - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc CMS1_k127_168667_1 861299.J421_1165 1.199e-104 346.0 COG1192@1|root,COG1192@2|Bacteria,1ZTH2@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 CMS1_k127_168667_13 379066.GAU_2212 0.0007249 51.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUC7@142182|Gemmatimonadetes 142182|Gemmatimonadetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_168667_0 572477.Alvin_3075 7.012e-192 619.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales 135613|Chromatiales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc CMS1_k127_168667_10 292415.Tbd_0653 3.247e-19 93.0 COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,2VVHG@28216|Betaproteobacteria 28216|Betaproteobacteria M 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP CMS1_k127_168667_2 1234364.AMSF01000024_gene3767 7.472e-90 312.0 COG1668@1|root,COG1668@2|Bacteria,1R62N@1224|Proteobacteria 1224|Proteobacteria CP COG1668 ABC-type Na efflux pump, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS1_k127_168667_11 1234364.AMSF01000024_gene3768 2.345e-17 85.0 COG4152@1|root,COG4152@2|Bacteria,1QUPV@1224|Proteobacteria,1T47Q@1236|Gammaproteobacteria,1XD8K@135614|Xanthomonadales 135614|Xanthomonadales S ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_174303_0 1379270.AUXF01000007_gene994 1.259e-93 332.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_178664_11 1379270.AUXF01000002_gene1589 1.47e-44 163.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_178664_2 1379270.AUXF01000002_gene1600 1.204e-175 583.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_178664_7 1379270.AUXF01000002_gene1150 1.251e-137 465.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1150|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_178664_12 234267.Acid_7637 1.132e-36 153.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_178664_10 1379270.AUXF01000002_gene1587 9.758e-86 301.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1587|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_178664_3 1379270.AUXF01000002_gene1583 1.031e-169 571.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1583|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_178664_1 1379270.AUXF01000002_gene1586 1.135e-187 617.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_178664_0 861299.J421_1230 3.175e-197 650.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_178664_5 1379270.AUXF01000002_gene1585 3.912e-165 552.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_178664_6 1379270.AUXF01000002_gene1583 1.347e-163 549.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1583|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_178664_9 504472.Slin_5510 3.908e-92 316.0 COG0346@1|root,COG0346@2|Bacteria,4NGE0@976|Bacteroidetes,47KJP@768503|Cytophagia 976|Bacteroidetes E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K15975 - - - - ko00000 - - - Glyoxalase CMS1_k127_178664_8 1379270.AUXF01000002_gene1585 6.253e-116 409.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_178664_4 880073.Calab_2811 3.158e-169 559.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2NPC4@2323|unclassified Bacteria 2|Bacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - iAF987.Gmet_3470 CBS,TrkA_C,Voltage_CLC CMS1_k127_1804912_32 861299.J421_2798 6.723e-61 234.0 COG0483@1|root,COG0483@2|Bacteria,1ZTQA@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P CMS1_k127_1804912_7 861299.J421_2799 9.756e-143 460.0 COG0180@1|root,COG0180@2|Bacteria,1ZT3P@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b CMS1_k127_1804912_28 379066.GAU_0902 5.04e-71 256.0 COG0111@1|root,COG0111@2|Bacteria,1ZUG6@142182|Gemmatimonadetes 142182|Gemmatimonadetes EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh_C CMS1_k127_1804912_13 861299.J421_2803 2.179e-102 359.0 COG2805@1|root,COG2805@2|Bacteria,1ZT2Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS1_k127_1804912_33 861299.J421_2804 6.057e-60 231.0 COG0329@1|root,COG0329@2|Bacteria,1ZTGV@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Dihydrodipicolinate synthetase family - - - - - - - - - - - - DHDPS CMS1_k127_1804912_3 379066.GAU_0907 1.568e-181 578.0 COG0104@1|root,COG0104@2|Bacteria,1ZSNV@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt CMS1_k127_1804912_38 867903.ThesuDRAFT_01636 6.958e-51 194.0 COG1929@1|root,COG1929@2|Bacteria,1TPSI@1239|Firmicutes,249SH@186801|Clostridia 186801|Clostridia G Belongs to the glycerate kinase type-1 family - - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase CMS1_k127_1804912_1 880073.Calab_2803 6.56e-211 667.0 COG0423@1|root,COG0423@2|Bacteria,2NNN9@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSB619.SA_RS07880 HGTP_anticodon,tRNA-synt_2b CMS1_k127_1804912_12 861299.J421_2812 1.083e-112 390.0 COG1164@1|root,COG1164@2|Bacteria 2|Bacteria E metalloendopeptidase activity - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - - CMS1_k127_1804912_46 1123388.AQWU01000055_gene1501 2.777e-19 97.0 COG3824@1|root,COG3824@2|Bacteria,1WJSP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Zincin-like metallopeptidase - - - - - - - - - - - - Zincin_1 CMS1_k127_1804912_49 379066.GAU_0913 1.31e-12 71.0 2FC5K@1|root,3449E@2|Bacteria,1ZU4V@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1804912_23 861299.J421_2819 5.755e-84 292.0 COG0123@1|root,COG0123@2|Bacteria,1ZSKN@142182|Gemmatimonadetes 142182|Gemmatimonadetes BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl CMS1_k127_1804912_45 861299.J421_2820 9.697e-21 104.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - MetW,Methyltransf_11,Methyltransf_20,Methyltransf_23,Methyltransf_25,Methyltransf_31 CMS1_k127_1804912_8 235909.GK1170 5.806e-142 493.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,1WEMW@129337|Geobacillus 91061|Bacilli L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII CMS1_k127_1804912_39 861299.J421_2828 3.818e-43 165.0 COG0735@1|root,COG0735@2|Bacteria,1ZTN4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Ferric uptake regulator family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR CMS1_k127_1804912_31 368407.Memar_2150 2.45e-64 225.0 COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia 224756|Methanomicrobia E Belongs to the PdaD family pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC CMS1_k127_1804912_25 335543.Sfum_0721 2.395e-76 267.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,42NBC@68525|delta/epsilon subdivisions,2WIMR@28221|Deltaproteobacteria,2MRRB@213462|Syntrophobacterales 28221|Deltaproteobacteria E Belongs to the arginase family speB - 3.5.3.1,3.5.3.11 ko:K01476,ko:K01480 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00133,M00134 R00551,R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase CMS1_k127_1804912_24 861299.J421_2831 8.755e-81 275.0 COG0785@1|root,COG0785@2|Bacteria,1ZTJC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome C biogenesis protein transmembrane region - - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD CMS1_k127_1804912_53 234267.Acid_2436 5.979e-07 60.0 COG3170@1|root,COG3170@2|Bacteria,3Y4RX@57723|Acidobacteria 57723|Acidobacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - CMS1_k127_1804912_22 1173028.ANKO01000052_gene1671 1.265e-85 304.0 COG1732@1|root,COG1732@2|Bacteria,1G1ZS@1117|Cyanobacteria,1H9PY@1150|Oscillatoriales 1117|Cyanobacteria M PFAM Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC CMS1_k127_1804912_30 118173.KB235914_gene3320 6.688e-65 239.0 COG1174@1|root,COG1174@2|Bacteria,1G2ZA@1117|Cyanobacteria,1HAQ8@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1 CMS1_k127_1804912_27 1170562.Cal6303_4827 1.032e-74 269.0 COG1125@1|root,COG1125@2|Bacteria,1G21Q@1117|Cyanobacteria,1HIQ3@1161|Nostocales 1117|Cyanobacteria E ABC-type proline glycine betaine transport - - - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - ABC_tran,CBS CMS1_k127_1804912_4 1379270.AUXF01000004_gene2961 2.489e-161 526.0 COG0405@1|root,COG0405@2|Bacteria,1ZT0E@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS1_k127_1804912_14 379066.GAU_0935 2.521e-100 335.0 COG2103@1|root,COG2103@2|Bacteria,1ZT2A@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - - CMS1_k127_1804912_15 861299.J421_2839 9.623e-99 363.0 COG2377@1|root,COG2377@2|Bacteria,1ZSZI@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK CMS1_k127_1804912_51 105425.BBPL01000018_gene26 2.477e-09 70.0 COG0265@1|root,COG0265@2|Bacteria,2GJJ3@201174|Actinobacteria,2NHH0@228398|Streptacidiphilus 201174|Actinobacteria O Domain present in PSD-95, Dlg, and ZO-1/2. pepA - - ko:K08372 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Trypsin_2 CMS1_k127_1804912_52 1048339.KB913029_gene4268 3.798e-07 63.0 COG1716@1|root,COG1716@2|Bacteria,2I915@201174|Actinobacteria,4ETKF@85013|Frankiales 201174|Actinobacteria T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - FHA CMS1_k127_1804912_20 861299.J421_2843 1.527e-89 307.0 COG0631@1|root,COG0631@2|Bacteria,1ZT1X@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS1_k127_1804912_18 861299.J421_4066 2.374e-96 336.0 COG0515@1|root,COG0515@2|Bacteria,1ZTGA@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1804912_44 391625.PPSIR1_12623 2.604e-25 119.0 COG1716@1|root,COG1716@2|Bacteria 2|Bacteria T histone H2A K63-linked ubiquitination - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - FHA,Guanylate_cyc CMS1_k127_1804912_19 379066.GAU_0939 2.565e-93 330.0 COG0860@1|root,COG0860@2|Bacteria,1ZT6J@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 CMS1_k127_1804912_50 518766.Rmar_2301 2.31e-10 75.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_2301|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_1804912_29 861299.J421_2823 6.657e-66 250.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFI@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1804912_35 886293.Sinac_5721 2.881e-56 203.0 COG0663@1|root,COG0663@2|Bacteria,2IZP3@203682|Planctomycetes 203682|Planctomycetes S isoleucine patch - - - - - - - - - - - - Hexapep CMS1_k127_1804912_0 861299.J421_2847 0.0 1193.0 COG0209@1|root,COG0209@2|Bacteria,1ZSU9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN CMS1_k127_1804912_2 861299.J421_1297 2.062e-191 605.0 COG0821@1|root,COG0821@2|Bacteria,1ZST3@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE CMS1_k127_1804912_37 518766.Rmar_0355 3.229e-51 209.0 COG1629@1|root,COG4771@2|Bacteria,4NTQD@976|Bacteroidetes 976|Bacteroidetes P TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS1_k127_1804912_6 379066.GAU_1104 6.121e-147 483.0 COG0469@1|root,COG0469@2|Bacteria,1ZSMD@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Pyruvate kinase, barrel domain - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C CMS1_k127_1804912_17 1379270.AUXF01000005_gene378 1.134e-96 332.0 COG1235@1|root,COG1235@2|Bacteria,1ZT49@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - 3.1.4.55 ko:K06167 ko00440,map00440 - R10205 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 CMS1_k127_1804912_47 861299.J421_2877 1.032e-17 88.0 COG4980@1|root,COG4980@2|Bacteria,1ZU46@142182|Gemmatimonadetes 142182|Gemmatimonadetes S YtxH-like protein - - - - - - - - - - - - YtxH CMS1_k127_1804912_41 861299.J421_2878 4.393e-34 142.0 COG1295@1|root,COG1295@2|Bacteria,1ZTHX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB CMS1_k127_1804912_21 1379270.AUXF01000005_gene383 2.598e-89 322.0 COG2008@1|root,COG2008@2|Bacteria,1ZT2G@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS1_k127_1804912_10 1089550.ATTH01000001_gene1675 2.202e-117 404.0 COG0168@1|root,COG0168@2|Bacteria,4NF7R@976|Bacteroidetes,1FIT8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Cation transport protein - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH CMS1_k127_1804912_34 1297742.A176_05055 6.19e-57 205.0 COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,42PJH@68525|delta/epsilon subdivisions,2WMZT@28221|Deltaproteobacteria,2YVX6@29|Myxococcales 28221|Deltaproteobacteria C TrkA-C domain ktrA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N CMS1_k127_1804912_16 1449126.JQKL01000039_gene1065 2.549e-97 341.0 COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,2688V@186813|unclassified Clostridiales 186801|Clostridia P TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N CMS1_k127_1804912_11 644282.Deba_0609 2.502e-117 394.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH CMS1_k127_1804912_5 861299.J421_2881 3.082e-150 494.0 COG2812@1|root,COG2812@2|Bacteria,1ZTFV@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 CMS1_k127_1804912_42 861299.J421_2882 2.907e-28 124.0 COG0718@1|root,COG0718@2|Bacteria,1ZU1F@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd CMS1_k127_1804912_26 1379270.AUXF01000005_gene387 3.124e-75 257.0 COG0353@1|root,COG0353@2|Bacteria,1ZTJX@142182|Gemmatimonadetes 142182|Gemmatimonadetes L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 CMS1_k127_1804912_48 1379270.AUXF01000005_gene388 4.458e-16 84.0 29142@1|root,2ZNRG@2|Bacteria,1ZV6W@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1804912_36 379066.GAU_1115 1.571e-54 195.0 COG2018@1|root,COG2018@2|Bacteria,1ZTK7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Roadblock/LC7 domain - - - - - - - - - - - - Robl_LC7 CMS1_k127_1804912_9 379066.GAU_1116 5.242e-122 393.0 COG1100@1|root,COG1100@2|Bacteria,1ZSQI@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ADP-ribosylation factor family - - - ko:K06883 - - - - ko00000 - - - Arf CMS1_k127_1804912_40 1379270.AUXF01000005_gene391 1.921e-39 152.0 COG0558@1|root,COG0558@2|Bacteria,1ZSXG@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf CMS1_k127_1813867_1 1379270.AUXF01000006_gene112 7.931e-257 799.0 COG4799@1|root,COG4799@2|Bacteria,1ZTGE@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Carboxyl transferase domain - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans CMS1_k127_1813867_5 1379270.AUXF01000006_gene113 5.052e-181 581.0 COG0439@1|root,COG0439@2|Bacteria,1ZTBD@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS1_k127_1813867_19 861299.J421_3416 6.3e-75 276.0 COG2265@1|root,COG2265@2|Bacteria,1ZSPC@142182|Gemmatimonadetes 142182|Gemmatimonadetes H tRNA (Uracil-5-)-methyltransferase - - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr CMS1_k127_1813867_29 861299.J421_3415 2.55e-32 132.0 COG4770@1|root,COG4770@2|Bacteria,1ZTVQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin-requiring enzyme - - - - - - - - - - - - Biotin_lipoyl CMS1_k127_1813867_23 1379270.AUXF01000006_gene117 1.144e-64 224.0 COG0102@1|root,COG0102@2|Bacteria,1ZTIS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 CMS1_k127_1813867_26 861299.J421_3413 7.205e-49 182.0 COG0103@1|root,COG0103@2|Bacteria,1ZTM0@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S9/S16 rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 CMS1_k127_1813867_15 1379270.AUXF01000006_gene119 8.63e-103 344.0 COG0052@1|root,COG0052@2|Bacteria,1ZSNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S2 rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 CMS1_k127_1813867_22 1121438.JNJA01000007_gene1764 7.562e-65 228.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria,2M9B7@213115|Desulfovibrionales 28221|Deltaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS CMS1_k127_1813867_16 1379270.AUXF01000006_gene121 6.544e-92 317.0 COG0528@1|root,COG0528@2|Bacteria,1ZSY2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase CMS1_k127_1813867_25 861299.J421_3409 9.17e-60 212.0 COG0233@1|root,COG0233@2|Bacteria,1ZTI2@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF CMS1_k127_1813867_27 1379270.AUXF01000006_gene124 3.338e-41 162.0 COG4589@1|root,COG4589@2|Bacteria,1ZTGH@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Cytidylyltransferase family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 CMS1_k127_1813867_9 379066.GAU_1770 2.362e-125 432.0 COG0743@1|root,COG0743@2|Bacteria,1ZTFR@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom CMS1_k127_1813867_24 1441629.PCH70_12550 3.141e-63 241.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1Z52F@136849|Pseudomonas syringae group 1236|Gammaproteobacteria M Peptidase family M50 rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 CMS1_k127_1813867_18 379066.GAU_1766 1.087e-78 274.0 COG0515@1|root,COG0515@2|Bacteria,1ZTE2@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1813867_30 1122939.ATUD01000005_gene2723 5.042e-30 121.0 COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4CQF0@84995|Rubrobacteria 84995|Rubrobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 CMS1_k127_1813867_0 379066.GAU_1764 1.443e-294 921.0 COG1185@1|root,COG1185@2|Bacteria,1ZT7C@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 CMS1_k127_1813867_12 1379270.AUXF01000006_gene131 7.963e-122 424.0 COG0612@1|root,COG0612@2|Bacteria,1ZSPT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_1813867_6 861299.J421_3399 1.406e-172 548.0 COG0686@1|root,COG0686@2|Bacteria,1ZSSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Alanine dehydrogenase/PNT, N-terminal domain - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N CMS1_k127_1813867_4 861299.J421_3398 2.187e-186 587.0 COG1077@1|root,COG1077@2|Bacteria,1ZT9B@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Hsp70 protein - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl CMS1_k127_1813867_28 379066.GAU_1760 1.577e-40 171.0 COG1792@1|root,COG1792@2|Bacteria,1ZSYE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M rod shape-determining protein MreC - - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC CMS1_k127_1813867_31 861299.J421_3396 1.771e-28 123.0 2CIX2@1|root,33ZZP@2|Bacteria,1ZTZK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S rod shape-determining protein MreD - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD CMS1_k127_1813867_7 379066.GAU_1758 4.29e-158 523.0 COG0768@1|root,COG0768@2|Bacteria,1ZSX5@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Penicillin-binding Protein dimerisation domain - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase CMS1_k127_1813867_11 379066.GAU_1757 7.143e-125 417.0 COG0772@1|root,COG0772@2|Bacteria,1ZSXM@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell cycle protein - - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE CMS1_k127_1813867_14 379066.GAU_1756 7.24e-107 353.0 COG0777@1|root,COG0777@2|Bacteria,1ZSSK@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans CMS1_k127_1813867_17 379066.GAU_1755 8.349e-91 321.0 COG0285@1|root,COG0285@2|Bacteria,1ZSRP@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Mur ligase middle domain - - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M CMS1_k127_1813867_10 861299.J421_3391 4.888e-125 413.0 COG0124@1|root,COG0124@2|Bacteria,1ZSXX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_His CMS1_k127_1813867_3 861299.J421_3390 1.34e-207 662.0 COG0442@1|root,COG0442@2|Bacteria,1ZT48@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b CMS1_k127_1813867_13 1379270.AUXF01000006_gene142 4.901e-108 366.0 COG0019@1|root,COG0019@2|Bacteria,1ZT6G@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC CMS1_k127_1813867_2 379066.GAU_1750 2.187e-234 735.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1ZSMF@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase CMS1_k127_1813867_20 379066.GAU_1741 1.398e-69 239.0 COG1762@1|root,COG1762@2|Bacteria,1ZTIY@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 CMS1_k127_1813867_8 861299.J421_3385 6.271e-127 414.0 COG0042@1|root,COG0042@2|Bacteria,1ZSQC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - - - - - - - - - - Dus CMS1_k127_1813867_21 1125863.JAFN01000001_gene1413 2.715e-66 242.0 COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC CMS1_k127_182630_2 517418.Ctha_1804 5.35e-67 236.0 COG2859@1|root,COG2859@2|Bacteria,1FEXS@1090|Chlorobi 1090|Chlorobi S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL CMS1_k127_182630_1 1267533.KB906733_gene3281 1.599e-127 445.0 COG1680@1|root,COG1680@2|Bacteria 2|Bacteria V peptidase activity - - - - - - - - - - - - Beta-lactamase CMS1_k127_182630_4 1237149.C900_03052 1.414e-41 177.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,4NFZR@976|Bacteroidetes,47N0I@768503|Cytophagia 976|Bacteroidetes M PFAM peptidase M28 - - - - - - - - - - - - PD40,PDZ_2,Peptidase_M28 CMS1_k127_182630_0 378806.STAUR_8168 2.265e-300 952.0 COG1629@1|root,COG4771@2|Bacteria,1QX6X@1224|Proteobacteria,43BZN@68525|delta/epsilon subdivisions,2X7AF@28221|Deltaproteobacteria,2Z3EM@29|Myxococcales 28221|Deltaproteobacteria M CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug CMS1_k127_182630_3 483219.LILAB_31685 1.54e-46 185.0 COG3193@1|root,COG3193@2|Bacteria,1QX6Y@1224|Proteobacteria,43BZP@68525|delta/epsilon subdivisions,2X7AG@28221|Deltaproteobacteria,2YU0D@29|Myxococcales 28221|Deltaproteobacteria S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD_RagB CMS1_k127_1835653_0 62928.azo2614 2.477e-26 110.0 2E5ES@1|root,3306N@2|Bacteria,1N5VN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_1835653_1 1321778.HMPREF1982_02317 3.773e-24 115.0 COG0308@1|root,COG0308@2|Bacteria,1URF6@1239|Firmicutes,24WU6@186801|Clostridia 186801|Clostridia E aminopeptidase N - - - - - - - - - - - - - CMS1_k127_1842347_3 1230476.C207_03286 0.0003761 47.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3JR8N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_transf_41,Methyltransf_23,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 CMS1_k127_1842347_2 1278073.MYSTI_05664 1.819e-13 83.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Aminotran_5,DUF4377,Lactamase_B,Rhodanese CMS1_k127_1842347_0 396588.Tgr7_1082 6.966e-235 737.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS1_k127_1842347_1 935848.JAEN01000007_gene2972 3.495e-19 94.0 COG2334@1|root,COG2334@2|Bacteria,1MXTW@1224|Proteobacteria,2U31H@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Phosphotransferase enzyme family - - - - - - - - - - - - APH CMS1_k127_1844724_3 1169144.KB910964_gene2949 0.0006667 44.0 COG0739@1|root,COG3103@1|root,COG0739@2|Bacteria,COG3103@2|Bacteria,1TRWJ@1239|Firmicutes,4HWZ3@91061|Bacilli,1ZM17@1386|Bacillus 91061|Bacilli MT Bacterial SH3 domain - - - - - - - - - - - - Peptidase_M23,SH3_3 CMS1_k127_1844724_0 234267.Acid_1970 3.816e-88 310.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - - - - - - - - - - - CBM_2,DUF2048,Peptidase_S9 CMS1_k127_1844724_2 1122604.JONR01000008_gene2129 3.768e-14 75.0 COG1266@1|root,COG1266@2|Bacteria,1NXKQ@1224|Proteobacteria 1224|Proteobacteria S CAAX protease self-immunity - - - - - - - - - - - - Abi CMS1_k127_1848334_20 861299.J421_3453 4.17e-94 328.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1ZSPW@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE CMS1_k127_1848334_27 861299.J421_3452 1.942e-61 222.0 COG0030@1|root,COG0030@2|Bacteria,1ZT2M@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD CMS1_k127_1848334_24 861299.J421_3451 9.468e-68 236.0 COG2344@1|root,COG2344@2|Bacteria,1ZTJV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N CMS1_k127_1848334_22 889378.Spiaf_1193 5.727e-75 267.0 COG2235@1|root,COG2235@2|Bacteria,2J57H@203691|Spirochaetes 203691|Spirochaetes E Arginine - - 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 - R00552 RC00177 ko00000,ko00001,ko01000 - - - Amidinotransf CMS1_k127_1848334_28 1379270.AUXF01000006_gene80 1.784e-57 216.0 COG0847@1|root,COG0847@2|Bacteria,1ZTNH@142182|Gemmatimonadetes 142182|Gemmatimonadetes L EXOIII - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T CMS1_k127_1848334_14 1379270.AUXF01000006_gene81 4.812e-107 368.0 COG0491@1|root,COG0491@2|Bacteria,1ZT7V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B CMS1_k127_1848334_25 379066.GAU_1878 8.631e-67 235.0 COG0290@1|root,COG0290@2|Bacteria,1ZTM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N CMS1_k127_1848334_40 37659.JNLN01000001_gene2259 1.956e-10 64.0 COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,36MNG@31979|Clostridiaceae 186801|Clostridia J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p CMS1_k127_1848334_33 379066.GAU_1876 1.504e-38 147.0 COG0292@1|root,COG0292@2|Bacteria,1ZTUF@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 CMS1_k127_1848334_17 396588.Tgr7_1454 9.655e-103 346.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1WXAD@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d CMS1_k127_1848334_6 861299.J421_3444 2.21e-186 614.0 COG0072@1|root,COG0072@2|Bacteria,1ZSWJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J B3/4 domain pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind CMS1_k127_1848334_37 1379270.AUXF01000006_gene88 8.157e-16 85.0 COG3027@1|root,COG3027@2|Bacteria,1ZU4G@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA CMS1_k127_1848334_2 861299.J421_3441 7.554e-203 644.0 COG1418@1|root,COG1418@2|Bacteria,1ZT0I@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 CMS1_k127_1848334_16 1403819.BATR01000177_gene5953 1.13e-104 351.0 COG0190@1|root,COG0190@2|Bacteria,46TG7@74201|Verrucomicrobia,2ITSZ@203494|Verrucomicrobiae 203494|Verrucomicrobiae H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C CMS1_k127_1848334_19 861299.J421_3439 4.106e-96 339.0 COG1570@1|root,COG1570@2|Bacteria,1ZT8T@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 CMS1_k127_1848334_21 861299.J421_3437 9.079e-81 279.0 COG0142@1|root,COG0142@2|Bacteria,1ZSR3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Polyprenyl synthetase - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt CMS1_k127_1848334_1 861299.J421_3436 2.247e-245 783.0 COG1154@1|root,COG1154@2|Bacteria,1ZSP2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C CMS1_k127_1848334_26 861299.J421_3435 4.173e-64 247.0 COG0061@1|root,COG0061@2|Bacteria,1ZT32@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase CMS1_k127_1848334_11 861299.J421_3434 5.652e-135 449.0 COG0497@1|root,COG0497@2|Bacteria,1ZSV4@142182|Gemmatimonadetes 142182|Gemmatimonadetes L May be involved in recombinational repair of damaged DNA - - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N CMS1_k127_1848334_36 1379270.AUXF01000006_gene97 7.791e-17 94.0 2C3N7@1|root,33YDV@2|Bacteria,1ZTRI@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1848334_23 518766.Rmar_0133 5.223e-69 263.0 COG2755@1|root,COG2755@2|Bacteria,4PM67@976|Bacteroidetes,1FJ25@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - - CMS1_k127_1848334_18 1089550.ATTH01000001_gene487 1.353e-100 366.0 COG2067@1|root,COG2067@2|Bacteria,4NFFF@976|Bacteroidetes,1FIPQ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X CMS1_k127_1848334_13 861299.J421_1864 1.02e-112 386.0 COG0038@1|root,COG0038@2|Bacteria 2|Bacteria P chloride channel clcA - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC CMS1_k127_1848334_5 1232410.KI421424_gene1584 9.341e-188 608.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria,43U48@69541|Desulfuromonadales 28221|Deltaproteobacteria P Ferrous iron transport protein B C terminus feoB-1 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate CMS1_k127_1848334_42 443144.GM21_2624 1.091e-07 65.0 2DST5@1|root,33HC3@2|Bacteria,1NMTA@1224|Proteobacteria,42XYN@68525|delta/epsilon subdivisions,2WT9U@28221|Deltaproteobacteria,43VXG@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_1848334_41 1125863.JAFN01000001_gene2642 1.238e-08 63.0 COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1N3ZM@1224|Proteobacteria,42TUU@68525|delta/epsilon subdivisions,2WQ8Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria KP PFAM iron dependent repressor - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,FeoA CMS1_k127_1848334_34 1123253.AUBD01000005_gene11 7.891e-30 124.0 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1T5A0@1236|Gammaproteobacteria,1XDFF@135614|Xanthomonadales 135614|Xanthomonadales S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS CMS1_k127_1848334_35 351607.Acel_0183 1.923e-25 118.0 COG0451@1|root,COG0451@2|Bacteria,2I2SW@201174|Actinobacteria,4ETNA@85013|Frankiales 201174|Actinobacteria GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10 CMS1_k127_1848334_43 1047013.AQSP01000142_gene124 2.743e-05 57.0 COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria 2|Bacteria O NHL repeat - - - - - - - - - - - - DUF5128,NHL,TolB_like CMS1_k127_1848334_7 1434325.AZQN01000001_gene196 4.119e-166 556.0 COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,47JKY@768503|Cytophagia 976|Bacteroidetes P C-terminal region of aryl-sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C CMS1_k127_1848334_3 314230.DSM3645_11382 1.448e-193 617.0 COG3119@1|root,COG3119@2|Bacteria,2IX2H@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A - - 3.1.6.14 ko:K01137 ko00531,ko01100,ko04142,map00531,map01100,map04142 M00078,M00079 R07808,R07819 - ko00000,ko00001,ko00002,ko01000 - - - DUF4976,Sulfatase CMS1_k127_1848334_39 1380390.JIAT01000009_gene1359 1.269e-10 74.0 COG3391@1|root,COG3391@2|Bacteria,2GWAV@201174|Actinobacteria,4CRHS@84995|Rubrobacteria 84995|Rubrobacteria S WD40 repeats - - - - - - - - - - - - NHL CMS1_k127_1848334_29 671143.DAMO_0917 1.142e-52 200.0 COG0615@1|root,COG0615@2|Bacteria,2NRS5@2323|unclassified Bacteria 2|Bacteria IM Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 CMS1_k127_1848334_12 1123258.AQXZ01000011_gene1655 1.223e-132 445.0 COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4G01K@85025|Nocardiaceae 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran CMS1_k127_1848334_30 290512.Paes_0346 1.067e-44 181.0 2DTDB@1|root,32UV2@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1848334_32 180281.CPCC7001_2331 6.73e-40 167.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Anp1,Gly_transf_sug,Glycos_transf_2 CMS1_k127_1848334_8 1207063.P24_04190 3.866e-162 522.0 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,1MVZ0@1224|Proteobacteria,2TUZJ@28211|Alphaproteobacteria,2JQYS@204441|Rhodospirillales 204441|Rhodospirillales S membrane protein, required for spore maturation in B.subtilis - - - - - - - - - - - - Gate CMS1_k127_1848334_9 247633.GP2143_01745 7.751e-140 469.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,1J4KZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG2133 Glucose sorbosone dehydrogenases - - - ko:K21430 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,GSDH CMS1_k127_1848334_15 643562.Daes_2120 6.93e-107 355.0 COG0730@1|root,COG0730@2|Bacteria,1PYDH@1224|Proteobacteria,42P28@68525|delta/epsilon subdivisions,2WK6D@28221|Deltaproteobacteria,2M87J@213115|Desulfovibrionales 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_1848334_44 1379270.AUXF01000001_gene2257 0.0002799 46.0 COG2133@1|root,COG2133@2|Bacteria,1ZUDS@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glucose / Sorbosone dehydrogenase - - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH CMS1_k127_1848334_31 1121468.AUBR01000038_gene1968 5.496e-41 159.0 COG1309@1|root,COG1309@2|Bacteria,1TRSH@1239|Firmicutes,24KA3@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - ko:K13770 - - - - ko00000,ko03000 - - - TetR_C_4,TetR_N CMS1_k127_1848334_0 1120972.AUMH01000015_gene1326 5.672e-251 797.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1TR8J@1239|Firmicutes,4H9XN@91061|Bacilli,277X4@186823|Alicyclobacillaceae 91061|Bacilli I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain fadN - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU32840 3HCDH,3HCDH_N,ECH_1 CMS1_k127_1848334_10 326427.Cagg_0348 1.216e-137 464.0 COG0183@1|root,COG0183@2|Bacteria,2G5YW@200795|Chloroflexi,3755G@32061|Chloroflexia 32061|Chloroflexia I Belongs to the thiolase family - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N CMS1_k127_1848334_4 1120973.AQXL01000126_gene2917 7.021e-188 605.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HB0J@91061|Bacilli,2785Q@186823|Alicyclobacillaceae 91061|Bacilli I Acyl-CoA dehydrogenase, N-terminal domain fadE - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_1851687_2 861299.J421_4087 1.245e-71 250.0 COG3408@1|root,COG3459@1|root,COG3408@2|Bacteria,COG3459@2|Bacteria 2|Bacteria G carbohydrate binding cbpA - 2.4.1.333 ko:K21298 - - - - ko00000,ko01000 - GH94 - BNR_2,F5_F8_type_C,Glyco_hydro_36,Glyco_transf_36,Trehalase CMS1_k127_1851687_3 113395.AXAI01000021_gene3448 8.364e-44 173.0 COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,3K0QI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Ubie_methyltran CMS1_k127_1851687_4 1267211.KI669560_gene1242 8.16e-21 97.0 COG1073@1|root,COG1073@2|Bacteria,4PN7H@976|Bacteroidetes,1J0MK@117747|Sphingobacteriia 976|Bacteroidetes S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 CMS1_k127_1851687_1 861299.J421_2852 9.151e-119 417.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_2852|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_1851687_0 1379270.AUXF01000004_gene3169 5.926e-150 501.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug,TonB_dep_Rec CMS1_k127_1856827_2 187272.Mlg_1309 4.099e-25 107.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1WWQ4@135613|Chromatiales 135613|Chromatiales K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Sigma54_activat CMS1_k127_1856827_1 670487.Ocepr_0558 5.53e-29 124.0 COG0607@1|root,COG0607@2|Bacteria 2|Bacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - Rhodanese CMS1_k127_1856827_4 748247.AZKH_0351 9.507e-05 55.0 COG2010@1|root,COG2010@2|Bacteria,1R6Z0@1224|Proteobacteria,2VRTH@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,DUF302 CMS1_k127_1856827_3 118005.AWNK01000010_gene334 8.574e-17 95.0 COG4633@1|root,COG4633@2|Bacteria 2|Bacteria - - silP - 1.9.3.1,3.6.3.54 ko:K02275,ko:K17686 ko00190,ko01100,ko01524,ko04016,map00190,map01100,map01524,map04016 M00155 R00081,R00086 RC00002,RC00016 ko00000,ko00001,ko00002,ko01000 3.A.3.5,3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1,DsbD_2,HMA CMS1_k127_1856827_0 118005.AWNK01000010_gene335 5.66e-100 342.0 COG0348@1|root,COG1622@1|root,COG0348@2|Bacteria,COG1622@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor vnfA - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1,Fer4_5,Sigma54_activat,cNMP_binding CMS1_k127_1857316_15 1089547.KB913013_gene294 1.528e-12 78.0 COG1073@1|root,COG1073@2|Bacteria,4NFRN@976|Bacteroidetes,47KAI@768503|Cytophagia 976|Bacteroidetes E alpha beta - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 CMS1_k127_1857316_10 1295642.H839_09313 1.711e-55 201.0 COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,4HJDZ@91061|Bacilli,1WFPG@129337|Geobacillus 91061|Bacilli S SdpI/YhfL protein family yvaZ GO:0008150,GO:0009636,GO:0042221,GO:0050896 - - - - - - - - - - DUF1648,SdpI CMS1_k127_1857316_13 1246484.D479_14222 1.205e-24 105.0 COG0640@1|root,COG0640@2|Bacteria,1UV3F@1239|Firmicutes,4I4FW@91061|Bacilli,3NG6Q@45667|Halobacillus 91061|Bacilli K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_5 CMS1_k127_1857316_6 378806.STAUR_7974 1.45e-90 314.0 COG1801@1|root,COG1801@2|Bacteria,1N4QE@1224|Proteobacteria,42PDW@68525|delta/epsilon subdivisions,2WK6H@28221|Deltaproteobacteria,2YVUI@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 CMS1_k127_1857316_14 338963.Pcar_0143 3.214e-21 102.0 29X52@1|root,30IU1@2|Bacteria,1N8YP@1224|Proteobacteria,42WWU@68525|delta/epsilon subdivisions,2WT2G@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_1857316_3 1201290.M902_1809 8.924e-152 517.0 COG2268@1|root,COG2268@2|Bacteria,1QIR4@1224|Proteobacteria,42Q0N@68525|delta/epsilon subdivisions,2WJDJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Band 7 protein - - - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot CMS1_k127_1857316_0 1379270.AUXF01000001_gene2296 3.702e-184 615.0 COG1196@1|root,COG1196@2|Bacteria,1ZU8V@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - CMS1_k127_1857316_11 497964.CfE428DRAFT_0777 1.734e-37 163.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - - - - - - - - - - BatA,VWA_2 CMS1_k127_1857316_5 1379270.AUXF01000001_gene2298 1.575e-91 316.0 COG1721@1|root,COG1721@2|Bacteria,1ZUD5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 CMS1_k127_1857316_4 1379270.AUXF01000001_gene2299 2.095e-145 470.0 COG0714@1|root,COG0714@2|Bacteria,1ZUSV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS1_k127_1857316_7 1379270.AUXF01000001_gene2300 3.004e-75 261.0 29X7K@1|root,30IWU@2|Bacteria,1ZUTH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 CMS1_k127_1857316_2 379066.GAU_3099 8.281e-156 528.0 COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,1ZUF5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_1857316_9 1379270.AUXF01000001_gene2302 5.576e-56 207.0 COG4249@1|root,COG4249@2|Bacteria,1ZUQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase C14 caspase catalytic subunit p20 - - - - - - - - - - - - - CMS1_k127_1857316_1 1379270.AUXF01000001_gene2303 1.278e-179 587.0 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1ZUB1@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative glutamine amidotransferase - - - - - - - - - - - - GATase1_like CMS1_k127_1857316_8 926566.Terro_0568 9.547e-57 210.0 2DBN7@1|root,2ZA2Y@2|Bacteria,3Y62R@57723|Acidobacteria,2JKP9@204432|Acidobacteriia 204432|Acidobacteriia S Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 CMS1_k127_1857316_12 479432.Sros_4819 3.416e-36 144.0 COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4ENBU@85012|Streptosporangiales 201174|Actinobacteria Q Multicopper oxidase - - 1.3.3.5 ko:K08100 ko00860,ko01110,map00860,map01110 - R02394 RC01983 ko00000,ko00001,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_1867681_2 1382359.JIAL01000001_gene180 1.211e-11 78.0 COG2823@1|root,COG2823@2|Bacteria,3Y7Q9@57723|Acidobacteria,2JMV8@204432|Acidobacteriia 204432|Acidobacteriia S Periplasmic or secreted lipoprotein - - - - - - - - - - - - BON CMS1_k127_1867681_0 1379270.AUXF01000007_gene1070 1.221e-125 417.0 COG4784@1|root,COG4784@2|Bacteria,1ZUKG@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 CMS1_k127_1879806_0 96561.Dole_2360 1.142e-56 225.0 COG3356@1|root,COG3356@2|Bacteria,1QW1Q@1224|Proteobacteria,43BRP@68525|delta/epsilon subdivisions,2X72J@28221|Deltaproteobacteria,2MMRW@213118|Desulfobacterales 28221|Deltaproteobacteria S Neutral/alkaline non-lysosomal ceramidase, N-terminal - - - - - - - - - - - - Ceramidase_alk CMS1_k127_1894587_73 1144343.PMI41_03620 5.426e-09 65.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,43RQ9@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - DUF1775,PCuAC CMS1_k127_1894587_53 106370.Francci3_2499 1.403e-48 182.0 COG1999@1|root,COG1999@2|Bacteria,2GKF0@201174|Actinobacteria,4EVKF@85013|Frankiales 201174|Actinobacteria S SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC CMS1_k127_1894587_39 861299.J421_2983 2.71e-83 282.0 COG0179@1|root,COG0179@2|Bacteria,1ZTIG@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - FAA_hydrolase CMS1_k127_1894587_46 469383.Cwoe_1283 2.943e-62 229.0 COG0189@1|root,COG0189@2|Bacteria,2HI2Z@201174|Actinobacteria,4CT1T@84995|Rubrobacteria 84995|Rubrobacteria HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - - - - - - - - - - - GSH-S_ATP CMS1_k127_1894587_65 754476.Q7A_1890 4.532e-26 126.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,460ZK@72273|Thiotrichales 72273|Thiotrichales J Belongs to the HSP15 family - - - ko:K04762 - - - - ko00000,ko03110 - - - S4 CMS1_k127_1894587_2 861299.J421_2659 1.444e-276 884.0 COG0612@1|root,COG0612@2|Bacteria,1ZT1M@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_1894587_78 68570.DC74_4617 5.756e-06 55.0 COG3631@1|root,COG3631@2|Bacteria,2IJQH@201174|Actinobacteria 201174|Actinobacteria S Limonene-1,2-epoxide hydrolase catalytic domain - - - ko:K06893 - - - - ko00000 - - - SnoaL_2 CMS1_k127_1894587_51 326427.Cagg_0668 3.328e-51 205.0 COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia 200795|Chloroflexi DZ PFAM regulator of chromosome condensation, RCC1 - - - - - - - - - - - - RCC1,RCC1_2 CMS1_k127_1894587_35 519989.ECTPHS_09667 2.99e-98 336.0 COG1914@1|root,COG1914@2|Bacteria,1MWET@1224|Proteobacteria,1RY2N@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Mn2 and Fe2 transporters of the NRAMP family Z012_09610 - - - - - - - - - - - Nramp CMS1_k127_1894587_56 379066.GAU_1377 1.236e-36 159.0 COG2050@1|root,COG2050@2|Bacteria,1ZV1I@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Domain of unknown function (DUF4442) - - - - - - - - - - - - DUF4442 CMS1_k127_1894587_20 379066.GAU_1376 2.456e-142 466.0 COG2070@1|root,COG2070@2|Bacteria,1ZUN8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Nitronate monooxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO CMS1_k127_1894587_50 861299.J421_0735 9.01e-52 192.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_0735|- S peptidyl-tyrosine sulfation - - - ko:K13992 - - - - ko00000,ko00194 - - - - CMS1_k127_1894587_4 861299.J421_2179 6.372e-252 801.0 COG0308@1|root,COG0308@2|Bacteria,1ZUT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 CMS1_k127_1894587_41 1033743.CAES01000033_gene1025 3.43e-76 260.0 COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,4HGWW@91061|Bacilli,26TEW@186822|Paenibacillaceae 91061|Bacilli L DNA-3-methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco CMS1_k127_1894587_76 3827.XP_004491214.1 1.954e-06 56.0 28IXY@1|root,2QR9K@2759|Eukaryota,37S7Y@33090|Viridiplantae,3GG0F@35493|Streptophyta,4JIRH@91835|fabids 35493|Streptophyta S abundant protein - - - - - - - - - - - - LEA_2 CMS1_k127_1894587_25 518766.Rmar_1990 1.446e-134 435.0 COG4257@1|root,COG4257@2|Bacteria 2|Bacteria V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - DUF5011 CMS1_k127_1894587_57 1480694.DC28_08755 4.606e-33 138.0 COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes 203691|Spirochaetes S PFAM Rhomboid family - - - - - - - - - - - - Rhomboid CMS1_k127_1894587_80 1123504.JQKD01000007_gene3300 0.0001781 50.0 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2VVS2@28216|Betaproteobacteria,4AFBH@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 CMS1_k127_1894587_62 379066.GAU_2739 6.561e-30 126.0 COG1278@1|root,COG1278@2|Bacteria,1ZV0Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Ribonuclease B OB domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS1_k127_1894587_61 861299.J421_3696 2.678e-30 122.0 COG0361@1|root,COG0361@2|Bacteria,1ZV5Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex - - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a CMS1_k127_1894587_13 518766.Rmar_2362 5.564e-152 511.0 COG1215@1|root,COG1215@2|Bacteria,4NH18@976|Bacteroidetes,1FJVU@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Glycosyl transferase family 21 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,Sulfatase CMS1_k127_1894587_58 518766.Rmar_2361 2.179e-32 140.0 COG1413@1|root,COG1413@2|Bacteria,4PF5C@976|Bacteroidetes,1FK66@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C HEAT repeats - - - - - - - - - - - - - CMS1_k127_1894587_66 518766.Rmar_2360 1.17e-25 117.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,4NQNT@976|Bacteroidetes 976|Bacteroidetes T PFAM Response regulator receiver domain - - - ko:K07668 ko02020,map02020 M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg CMS1_k127_1894587_79 573370.DMR_23030 7.821e-05 51.0 2AHRB@1|root,3183N@2|Bacteria,1PZRR@1224|Proteobacteria,43646@68525|delta/epsilon subdivisions,2X0N2@28221|Deltaproteobacteria,2MCW7@213115|Desulfovibrionales 28221|Deltaproteobacteria S Histidine Phosphotransfer domain - - - - - - - - - - - - Hpt CMS1_k127_1894587_70 1173027.Mic7113_4103 4.524e-21 96.0 COG1308@1|root,COG1308@2|Bacteria,1G83N@1117|Cyanobacteria,1HC9J@1150|Oscillatoriales 1117|Cyanobacteria K Domain of unknown function (DUF4342) - - - - - - - - - - - - DUF4342 CMS1_k127_1894587_74 290315.Clim_1409 4.861e-07 62.0 COG1196@1|root,COG1196@2|Bacteria,1FEWZ@1090|Chlorobi 1090|Chlorobi D Biogenesis of lysosome-related organelles complex-1 subunit 2 - - - - - - - - - - - - BLOC1_2 CMS1_k127_1894587_8 518766.Rmar_2129 2.027e-190 606.0 COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1FIWI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_1894587_6 338969.Rfer_0831 9.207e-221 713.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria,4ACBR@80864|Comamonadaceae 28216|Betaproteobacteria O AAA domain - - - - - - - - - - - - AAA_32,Lon_C CMS1_k127_1894587_28 518766.Rmar_1488 1.587e-126 413.0 COG1313@1|root,COG1313@2|Bacteria 2|Bacteria C radical SAM domain protein PflX - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM CMS1_k127_1894587_77 1123278.KB893444_gene1701 2.953e-06 59.0 COG2318@1|root,COG2318@2|Bacteria,4NSZK@976|Bacteroidetes,47R2E@768503|Cytophagia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_1894587_55 1125863.JAFN01000001_gene393 2.607e-39 153.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,42SBG@68525|delta/epsilon subdivisions,2WP66@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM AMMECR1 domain protein - - - ko:K09141 - - - - ko00000 - - - AMMECR1 CMS1_k127_1894587_81 563031.HMPREF0666_00403 0.0004635 53.0 2BZQ4@1|root,32TE6@2|Bacteria,4NTHT@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_1894587_52 1047013.AQSP01000130_gene1852 2.509e-49 186.0 COG0730@1|root,COG0730@2|Bacteria,2NQW7@2323|unclassified Bacteria 2|Bacteria S Sulfite exporter TauE/SafE VVA0548 - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_1894587_15 861299.J421_4340 1.482e-147 478.0 COG0520@1|root,COG0520@2|Bacteria,1ZSV8@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS1_k127_1894587_24 264462.Bd2628 6.321e-135 439.0 COG0655@1|root,COG2146@1|root,COG0655@2|Bacteria,COG2146@2|Bacteria,1QY2E@1224|Proteobacteria,43C9S@68525|delta/epsilon subdivisions,2WTXI@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Rieske [2Fe-2S] domain - - - - - - - - - - - - FMN_red,Rieske CMS1_k127_1894587_5 1124780.ANNU01000036_gene34 4.798e-225 719.0 COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,47M9P@768503|Cytophagia 976|Bacteroidetes E Amino acid permease - - - - - - - - - - - - AA_permease CMS1_k127_1894587_9 338969.Rfer_2478 9.553e-182 620.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria 28216|Betaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N CMS1_k127_1894587_16 365528.KB891222_gene783 1.737e-146 490.0 COG2303@1|root,COG2303@2|Bacteria,2GJKS@201174|Actinobacteria,4EV8F@85013|Frankiales 201174|Actinobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3 CMS1_k127_1894587_69 1191523.MROS_1521 2.165e-22 108.0 COG3271@1|root,COG3271@2|Bacteria 2|Bacteria - - - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - DUF3335,Peptidase_C39,Peptidase_C39_2,Peptidase_C70,TPR_16,TPR_19,TPR_2,TPR_8 CMS1_k127_1894587_38 1191523.MROS_1522 1.796e-83 290.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4,6.3.5.5 ko:K01921,ko:K01955 ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502 M00051 R00256,R00575,R01150,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Dala_Dala_lig_C CMS1_k127_1894587_42 266117.Rxyl_2372 3.389e-73 261.0 COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria,4CQ9H@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx CMS1_k127_1894587_0 1379270.AUXF01000005_gene635 2.378e-281 882.0 COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase CMS1_k127_1894587_18 1379270.AUXF01000005_gene634 4.019e-146 490.0 COG0297@1|root,COG0297@2|Bacteria,1ZUKP@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Synthesizes alpha-1,4-glucan chains using ADP-glucose - - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 CMS1_k127_1894587_30 1303518.CCALI_02107 4.916e-120 408.0 COG1543@1|root,COG1543@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 57 family - GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K03406,ko:K16149 ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko02035 - GH57 - DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1 CMS1_k127_1894587_22 861299.J421_0427 1.821e-135 462.0 COG1449@1|root,COG1449@2|Bacteria,1ZTEQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Domain of unknown function (DUF3536) - - - - - - - - - - - - DUF3536,Glyco_hydro_57 CMS1_k127_1894587_19 671143.DAMO_2883 1.17e-142 481.0 COG1449@1|root,COG1449@2|Bacteria,2NQNB@2323|unclassified Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 57 family amyA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 ko:K22451 ko00500,map00500 - R05196 RC00049 ko00000,ko00001,ko01000 - GH57 - DUF1925,DUF1926,Glyco_hydro_57 CMS1_k127_1894587_59 1232410.KI421428_gene1021 4.628e-32 127.0 COG0011@1|root,COG0011@2|Bacteria,1N2GU@1224|Proteobacteria,42UPF@68525|delta/epsilon subdivisions,2WR94@28221|Deltaproteobacteria,43W2X@69541|Desulfuromonadales 28221|Deltaproteobacteria S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP CMS1_k127_1894587_49 1470593.BW43_03390 2.77e-53 197.0 COG1443@1|root,COG1562@1|root,COG1443@2|Bacteria,COG1562@2|Bacteria,1R4ZD@1224|Proteobacteria,1RS93@1236|Gammaproteobacteria 1236|Gammaproteobacteria I PFAM Squalene phytoene synthase - - 2.5.1.21 ko:K00801 ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130 - R00702,R02872,R06223 RC00362,RC00796,RC02839 ko00000,ko00001,ko01000,ko01006 - - - SQS_PSY CMS1_k127_1894587_7 84531.JMTZ01000036_gene450 4.312e-215 697.0 COG3525@1|root,COG3534@1|root,COG3525@2|Bacteria,COG3534@2|Bacteria,1MVDE@1224|Proteobacteria,1RMNI@1236|Gammaproteobacteria,1X9BH@135614|Xanthomonadales 135614|Xanthomonadales G Glycosyl hydrolase family 20, catalytic domain - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - CHB_HEX_C_1,Glyco_hydro_20,Glyco_hydro_20b,PA14 CMS1_k127_1894587_34 765420.OSCT_2288 2.524e-105 354.0 COG0053@1|root,COG0053@2|Bacteria,2G5MK@200795|Chloroflexi,375BG@32061|Chloroflexia 32061|Chloroflexia P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer CMS1_k127_1894587_1 1379270.AUXF01000001_gene2138 8.069e-277 864.0 COG2382@1|root,COG2382@2|Bacteria,1ZUJ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes P esterase - - - - - - - - - - - - Esterase CMS1_k127_1894587_48 861299.J421_4541 1.901e-54 196.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigX - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 CMS1_k127_1894587_67 861299.J421_4540 2.895e-25 113.0 COG0296@1|root,COG0296@2|Bacteria 2|Bacteria G 1,4-alpha-glucan branching enzyme activity - - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - AMPK1_CBM,Alpha-amylase,Alpha-amylase_C,CBM_48 CMS1_k127_1894587_63 861299.J421_4539 8.195e-29 124.0 28YSJ@1|root,2ZKJZ@2|Bacteria,1ZU1U@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1894587_71 861299.J421_1304 7.77e-18 96.0 2C9AW@1|root,2ZUFM@2|Bacteria,1ZUCC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1894587_45 710111.FraQA3DRAFT_2348 5.889e-71 247.0 2ANI9@1|root,31DH5@2|Bacteria,2GJE8@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_1894587_64 1380390.JIAT01000010_gene4001 2.664e-28 129.0 COG0589@1|root,COG1670@1|root,COG0589@2|Bacteria,COG1670@2|Bacteria,2HP6J@201174|Actinobacteria,4CQIP@84995|Rubrobacteria 84995|Rubrobacteria J Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 CMS1_k127_1894587_11 1089550.ATTH01000001_gene1831 1.534e-169 565.0 COG0515@1|root,COG0515@2|Bacteria,4NPN9@976|Bacteroidetes,1FJI6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - NERD,Pkinase,TPR_12,TPR_8 CMS1_k127_1894587_32 76869.PputGB1_2643 6.688e-110 372.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria,1YYFC@136845|Pseudomonas putida group 1236|Gammaproteobacteria C PFAM Major facilitator superfamily - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC CMS1_k127_1894587_47 861299.J421_0621 2.103e-55 201.0 2AI77@1|root,318MJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_1894587_3 861299.J421_0622 3.873e-253 788.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K17285 - - - - ko00000,ko04147 - - - SBP56 CMS1_k127_1894587_60 546414.Deide_17390 2.072e-30 126.0 COG1846@1|root,COG1846@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity slyA - - - - - - - - - - - HTH_27,MarR,MarR_2 CMS1_k127_1894587_40 404589.Anae109_4065 4.848e-83 310.0 COG0702@1|root,COG0702@2|Bacteria,1N3GN@1224|Proteobacteria,43F3M@68525|delta/epsilon subdivisions,2X39K@28221|Deltaproteobacteria,2YUZE@29|Myxococcales 28221|Deltaproteobacteria GM NmrA-like family - - - - - - - - - - - - NmrA CMS1_k127_1894587_12 518766.Rmar_2091 8.692e-158 521.0 COG0624@1|root,COG0624@2|Bacteria,4NJEK@976|Bacteroidetes 976|Bacteroidetes E TIGRFAM amidase, hydantoinase carbamoylase family - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS1_k127_1894587_44 717785.HYPMC_2047 6.606e-72 247.0 COG2514@1|root,COG2514@2|Bacteria,1RBC7@1224|Proteobacteria,2U5JP@28211|Alphaproteobacteria,3N7EV@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Glyoxalase-like domain catE - 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase CMS1_k127_1894587_27 234267.Acid_2224 2.491e-128 424.0 COG0624@1|root,COG0624@2|Bacteria,3Y7TX@57723|Acidobacteria 57723|Acidobacteria E Peptidase family M20/M25/M40 - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS1_k127_1894587_10 1089550.ATTH01000001_gene1831 5.119e-179 593.0 COG0515@1|root,COG0515@2|Bacteria,4NPN9@976|Bacteroidetes,1FJI6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - NERD,Pkinase,TPR_12,TPR_8 CMS1_k127_1894587_14 861299.J421_1475 2.96e-149 484.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS1_k127_1894587_21 861299.J421_1476 4.786e-140 452.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 CMS1_k127_1894587_17 251221.35211765 3.244e-146 497.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_1894587_33 318161.Sden_0954 2.701e-107 365.0 COG0793@1|root,COG0793@2|Bacteria 2|Bacteria M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S41,TPR_8,Tricorn_C1 CMS1_k127_1894587_29 1122604.JONR01000010_gene3913 2.97e-125 423.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,1X4RX@135614|Xanthomonadales 135614|Xanthomonadales E Serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 CMS1_k127_1894587_75 478741.JAFS01000001_gene2221 7.491e-07 59.0 COG5652@1|root,COG5652@2|Bacteria,46Z0R@74201|Verrucomicrobia,37GZJ@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S VanZ like family - - - - - - - - - - - - VanZ CMS1_k127_1894587_31 1234364.AMSF01000036_gene241 4.291e-112 374.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1S9NJ@1236|Gammaproteobacteria,1X5C8@135614|Xanthomonadales 135614|Xanthomonadales P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - 1.14.12.1,1.14.15.7 ko:K00499,ko:K16319 ko00260,ko00627,ko01120,map00260,map00627,map01120 M00637 R00823,R00825,R07409 RC00087,RC00192 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske,Ring_hydroxyl_A CMS1_k127_1894587_43 1163407.UU7_04737 1.638e-72 258.0 COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,1RN0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Amidinotransferase - - 3.5.3.18 ko:K01482 - - - - ko00000,ko01000,ko04147 - - - Amidinotransf CMS1_k127_1894587_26 694431.DESACE_06845 8.339e-130 430.0 COG3425@1|root,COG3425@2|Bacteria,1MU4K@1224|Proteobacteria,42M1Q@68525|delta/epsilon subdivisions,2WKSA@28221|Deltaproteobacteria 28221|Deltaproteobacteria I synthase mvaS - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - HMG_CoA_synt_C,HMG_CoA_synt_N CMS1_k127_1894587_23 456442.Mboo_0156 5.46e-135 443.0 COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia 224756|Methanomicrobia I PFAM Thiolase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAF692.Mbar_A0550 Thiolase_C,Thiolase_N CMS1_k127_1894587_68 694431.DESACE_06835 3.5e-25 121.0 COG1545@1|root,COG1545@2|Bacteria 2|Bacteria I DUF35 OB-fold domain, acyl-CoA-associated phlB - - ko:K07068,ko:K07549 ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220 M00418 R05587 RC00004,RC01428,RC02904 ko00000,ko00001,ko00002,ko01000 - - - DUF35_N,OB_aCoA_assoc CMS1_k127_1894587_36 270374.MELB17_23125 9.238e-97 320.0 COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,1S00N@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Amidases related to nicotinamidase - - - - - - - - - - - - Isochorismatase CMS1_k127_1894587_54 375286.mma_0959 3.752e-43 169.0 COG4977@1|root,COG4977@2|Bacteria,1R8XV@1224|Proteobacteria,2VKI6@28216|Betaproteobacteria 28216|Betaproteobacteria K Cupin - - - - - - - - - - - - Cupin_6,HTH_18 CMS1_k127_1909077_47 861299.J421_0465 3.912e-11 72.0 COG0823@1|root,COG0823@2|Bacteria,1ZTFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS1_k127_1909077_7 357808.RoseRS_4038 3.675e-167 536.0 COG0626@1|root,COG0626@2|Bacteria,2G7Q6@200795|Chloroflexi,3770M@32061|Chloroflexia 32061|Chloroflexia H PFAM Cys Met metabolism pyridoxal-phosphate-dependent - - 4.4.1.11 ko:K01761 ko00270,ko00450,map00270,map00450 - R00654,R04770 RC00196,RC00348,RC01209,RC01210 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP CMS1_k127_1909077_45 216432.CA2559_02030 1.588e-20 107.0 2DBBT@1|root,2Z8AC@2|Bacteria,4NIRZ@976|Bacteroidetes,1HZMZ@117743|Flavobacteriia 976|Bacteroidetes S Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg CMS1_k127_1909077_10 234267.Acid_3450 4.302e-157 507.0 COG0520@1|root,COG0520@2|Bacteria,3Y4TH@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS1_k127_1909077_39 861299.J421_4349 2.567e-29 131.0 COG3346@1|root,COG3346@2|Bacteria,1ZTTS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SURF1 family - - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 CMS1_k127_1909077_5 945713.IALB_0332 2.921e-206 666.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec CMS1_k127_1909077_22 861299.J421_1404 1.862e-77 267.0 COG0120@1|root,COG0120@2|Bacteria 2|Bacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 ko:K00851,ko:K00852,ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01051,R01056,R01737,R02750 RC00002,RC00017,RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A CMS1_k127_1909077_13 479434.Sthe_2434 3.191e-129 437.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi,27XXA@189775|Thermomicrobia 189775|Thermomicrobia G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2,5.3.1.9 ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000 - - - PGI,TAL_FSA CMS1_k127_1909077_2 861299.J421_1532 4.184e-268 854.0 COG0021@1|root,COG0021@2|Bacteria,1ZTA2@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N CMS1_k127_1909077_0 479434.Sthe_2772 0.0 1154.0 COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi,27XND@189775|Thermomicrobia 189775|Thermomicrobia C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C CMS1_k127_1909077_21 472759.Nhal_1354 1.043e-78 278.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1WYC3@135613|Chromatiales 135613|Chromatiales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin CMS1_k127_1909077_34 450851.PHZ_c2202 1.889e-46 192.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - - - - - - - - - - Lactamase_B CMS1_k127_1909077_41 1121439.dsat_1841 1.029e-27 129.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,42UF8@68525|delta/epsilon subdivisions,2WR6W@28221|Deltaproteobacteria,2MBZF@213115|Desulfovibrionales 28221|Deltaproteobacteria J PFAM Class I peptide chain release factor - - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 CMS1_k127_1909077_8 756067.MicvaDRAFT_5490 1.587e-164 531.0 COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria,1H8G7@1150|Oscillatoriales 1117|Cyanobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB CMS1_k127_1909077_40 388467.A19Y_3660 2.715e-29 132.0 COG3288@1|root,COG3288@2|Bacteria,1G711@1117|Cyanobacteria,1HBSJ@1150|Oscillatoriales 1117|Cyanobacteria C NAD NADP transhydrogenase alpha subunit pntA-2 - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM CMS1_k127_1909077_16 118168.MC7420_5104 9.149e-118 389.0 COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1H7A5@1150|Oscillatoriales 1117|Cyanobacteria C NAD NADP transhydrogenase alpha subunit pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM CMS1_k127_1909077_15 330214.NIDE1574 2.398e-120 396.0 COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_14,Mob_synth_C,Radical_SAM CMS1_k127_1909077_31 1278073.MYSTI_01180 1.625e-57 212.0 COG1988@1|root,COG1988@2|Bacteria,1RA9E@1224|Proteobacteria,438D4@68525|delta/epsilon subdivisions,2X3NA@28221|Deltaproteobacteria,2YWMP@29|Myxococcales 28221|Deltaproteobacteria S LexA-binding, inner membrane-associated putative hydrolase - - - ko:K07038 - - - - ko00000 - - - YdjM CMS1_k127_1909077_44 1379698.RBG1_1C00001G0517 4.674e-23 109.0 COG0489@1|root,COG0489@2|Bacteria,2NNX1@2323|unclassified Bacteria 2|Bacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA CMS1_k127_1909077_38 751945.Theos_0407 1.393e-32 139.0 COG1764@1|root,COG1764@2|Bacteria,1WJVD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O redox protein regulator of disulfide bond formation osmC - - ko:K04063 - - - - ko00000 - - - OsmC CMS1_k127_1909077_20 105559.Nwat_0740 3.613e-79 276.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1WWM3@135613|Chromatiales 135613|Chromatiales S PFAM Alpha beta hydrolase - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4 CMS1_k127_1909077_35 880073.Calab_1819 6.289e-45 183.0 COG3170@1|root,COG3170@2|Bacteria,2NPXD@2323|unclassified Bacteria 2|Bacteria NU Tfp pilus assembly protein FimV - - 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - DUF4157,Pkinase CMS1_k127_1909077_18 880073.Calab_1818 3.308e-83 298.0 COG0803@1|root,COG0803@2|Bacteria,2NPH3@2323|unclassified Bacteria 2|Bacteria P Belongs to the bacterial solute-binding protein 9 family znuA - - ko:K02077,ko:K09815,ko:K09818 ko02010,map02010 M00242,M00243,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ZnuA CMS1_k127_1909077_25 880073.Calab_1817 4.206e-63 229.0 COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria 2|Bacteria U ABC 3 transport family znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 CMS1_k127_1909077_3 1408473.JHXO01000005_gene1630 1.454e-243 782.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,2FN1K@200643|Bacteroidia 976|Bacteroidetes EU Peptidase, S9A B C family, catalytic domain protein pop GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_1909077_33 382464.ABSI01000010_gene3853 6.999e-51 189.0 COG4912@1|root,COG4912@2|Bacteria 2|Bacteria L Dna alkylation repair - - - - - - - - - - - - DNA_alkylation CMS1_k127_1909077_14 331869.BAL199_19498 6.01e-122 400.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TUWV@28211|Alphaproteobacteria,4BRI7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme MA20_02330 - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_1909077_37 555500.I215_06187 1.674e-37 155.0 COG0628@1|root,COG0628@2|Bacteria,4NIB3@976|Bacteroidetes,1HYV6@117743|Flavobacteriia 976|Bacteroidetes S permease - - - - - - - - - - - - AI-2E_transport CMS1_k127_1909077_4 518766.Rmar_0629 1.477e-232 756.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes MU WD40-like Beta Propeller Repeat - - - - - - - - - - - - BSP,Bac_surface_Ag,PD40 CMS1_k127_1909077_9 861299.J421_4263 6.42e-158 514.0 COG2234@1|root,COG2234@2|Bacteria,1ZT06@142182|Gemmatimonadetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS1_k127_1909077_23 861299.J421_0340 7.918e-75 261.0 COG3595@1|root,COG3595@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4097,PA14 CMS1_k127_1909077_42 1382356.JQMP01000001_gene797 1.658e-27 116.0 COG1959@1|root,COG1959@2|Bacteria 2|Bacteria K 2 iron, 2 sulfur cluster binding - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 CMS1_k127_1909077_12 309807.SRU_0982 2.518e-129 424.0 COG5505@1|root,COG5505@2|Bacteria,4NE2H@976|Bacteroidetes,1FJQG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Protein of unknown function (DUF819) - - - - - - - - - - - - DUF819 CMS1_k127_1909077_29 1128421.JAGA01000003_gene2936 1.041e-59 220.0 COG0506@1|root,COG0506@2|Bacteria,2NPED@2323|unclassified Bacteria 2|Bacteria E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh CMS1_k127_1909077_46 1086011.HJ01_03478 2.998e-12 73.0 COG2374@1|root,COG4932@1|root,COG5184@1|root,COG2374@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,4NK5Z@976|Bacteroidetes,1IKKZ@117743|Flavobacteriia,2NTPP@237|Flavobacterium 976|Bacteroidetes DMZ Protein of unknown function (DUF3494) - - - - - - - - - - - - Big_5,DUF3494 CMS1_k127_1909077_49 1173028.ANKO01000197_gene6119 5.39e-07 59.0 COG0346@1|root,COG0346@2|Bacteria,1G5QD@1117|Cyanobacteria,1HBKU@1150|Oscillatoriales 1117|Cyanobacteria E Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K08234 - - - - ko00000 - - - Glyoxalase CMS1_k127_1909077_19 404380.Gbem_0238 1.126e-81 277.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 CMS1_k127_1909077_24 1297865.APJD01000015_gene3469 1.175e-70 259.0 COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,3JSHJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S hydrolase of the alpha beta-hydrolase fold - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_6,DLH,Thioesterase CMS1_k127_1909077_1 861299.J421_5987 1.563e-301 945.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria 2|Bacteria L DNA ligase (ATP) activity - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N CMS1_k127_1909077_17 861299.J421_5988 3.994e-89 302.0 COG1273@1|root,COG1273@2|Bacteria 2|Bacteria M With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku CMS1_k127_1909077_26 404589.Anae109_0937 1.035e-62 225.0 COG0457@1|root,COG0457@2|Bacteria,1N4HS@1224|Proteobacteria,43753@68525|delta/epsilon subdivisions,2X219@28221|Deltaproteobacteria,2Z10F@29|Myxococcales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11 CMS1_k127_1909077_30 1168034.FH5T_18400 1.11e-57 204.0 COG2606@1|root,COG2606@2|Bacteria,4P3TW@976|Bacteroidetes,2FXVH@200643|Bacteroidia 976|Bacteroidetes S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit CMS1_k127_1909077_28 644966.Tmar_0285 4.696e-60 237.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WCQQ@538999|Clostridiales incertae sedis 186801|Clostridia L UvrD/REP helicase N-terminal domain pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C CMS1_k127_1909077_51 350058.Mvan_3977 5.845e-05 55.0 COG1463@1|root,COG1463@2|Bacteria,2GNEP@201174|Actinobacteria,232GJ@1762|Mycobacteriaceae 201174|Actinobacteria Q Virulence factor Mce family protein mce3F - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - Mce4_CUP1,MlaD CMS1_k127_1909077_32 1122603.ATVI01000011_gene2021 6.486e-54 199.0 COG1024@1|root,COG1024@2|Bacteria,1N2V7@1224|Proteobacteria,1SG8Y@1236|Gammaproteobacteria,1XCY4@135614|Xanthomonadales 135614|Xanthomonadales I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 CMS1_k127_1909077_6 926550.CLDAP_16590 1.976e-186 593.0 COG2403@1|root,COG2403@2|Bacteria,2G7VS@200795|Chloroflexi 200795|Chloroflexi S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - - CMS1_k127_1909077_11 243231.GSU3318 1.427e-137 453.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales 28221|Deltaproteobacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139,DUF4140 CMS1_k127_1909077_27 479432.Sros_8330 4.172e-61 229.0 COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4EG4P@85012|Streptosporangiales 201174|Actinobacteria G Inositol monophosphatase family hisN GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,3.1.3.25 ko:K01092,ko:K05602 ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070 M00026,M00131 R01185,R01186,R01187,R03013 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P CMS1_k127_1909077_43 1173264.KI913949_gene823 8.016e-27 119.0 COG2335@1|root,COG2335@2|Bacteria,1G6R4@1117|Cyanobacteria,1HBIV@1150|Oscillatoriales 1117|Cyanobacteria M Secreted and surface protein containing fasciclin-like repeats - - - - - - - - - - - - Fasciclin CMS1_k127_1909077_36 373994.Riv7116_5095 7.74e-44 165.0 COG2335@1|root,COG2335@2|Bacteria,1G5TY@1117|Cyanobacteria,1HNEC@1161|Nostocales 1117|Cyanobacteria M COGs COG2335 Secreted and surface protein containing fasciclin-like repeats - - - - - - - - - - - - Fasciclin CMS1_k127_1910562_0 861299.J421_0470 2.286e-68 252.0 COG0515@1|root,COG0515@2|Bacteria,1ZURQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1910562_4 1379270.AUXF01000002_gene1587 1.907e-08 64.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1587|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_1910562_2 1502850.FG91_00423 1.652e-11 77.0 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - - ko:K07126 - - - - ko00000 - - - DUF900,Sel1 CMS1_k127_1910562_3 861299.J421_1152 2.894e-11 76.0 COG4968@1|root,COG4968@2|Bacteria,1ZTWU@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl CMS1_k127_1910562_1 861299.J421_6034 2.38e-47 194.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS1_k127_1943340_11 861299.J421_1494 4.646e-13 81.0 COG5492@1|root,COG5492@2|Bacteria,1ZSW8@142182|Gemmatimonadetes 142182|Gemmatimonadetes N domain, Protein - - - - - - - - - - - - Big_2 CMS1_k127_1943340_6 1121468.AUBR01000038_gene1956 6.823e-94 322.0 COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,42EMI@68295|Thermoanaerobacterales 186801|Clostridia S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 CMS1_k127_1943340_0 861299.J421_3479 7.588e-182 601.0 COG1596@1|root,COG1596@2|Bacteria,1ZUC0@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Polysaccharide biosynthesis/export protein - - - - - - - - - - - - Poly_export,SLBB CMS1_k127_1943340_10 33876.JNXY01000026_gene3554 3.344e-16 87.0 COG0236@1|root,COG0236@2|Bacteria,2GQSX@201174|Actinobacteria,4DFNW@85008|Micromonosporales 201174|Actinobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding CMS1_k127_1943340_7 234267.Acid_1362 4.667e-89 300.0 COG1028@1|root,COG1028@2|Bacteria,3Y3YM@57723|Acidobacteria 57723|Acidobacteria IQ Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_1943340_3 234267.Acid_1363 7.832e-125 425.0 COG0318@1|root,COG0318@2|Bacteria 2|Bacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding CMS1_k127_1943340_1 234267.Acid_1364 4.541e-152 495.0 COG1541@1|root,COG1541@2|Bacteria 2|Bacteria H phenylacetate-CoA ligase activity luxE - - - - - - - - - - - LuxE CMS1_k127_1943340_5 234267.Acid_1365 1.981e-95 342.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family luxC - - - - - - - - - - - LuxC CMS1_k127_1943340_8 903818.KI912269_gene13 1.717e-35 155.0 COG1045@1|root,COG1045@2|Bacteria 2|Bacteria E serine acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep CMS1_k127_1943340_4 443143.GM18_1453 1.581e-111 366.0 COG0500@1|root,COG2226@2|Bacteria,1QYJ7@1224|Proteobacteria,43CSU@68525|delta/epsilon subdivisions 1224|Proteobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 CMS1_k127_1943340_2 861299.J421_3496 5.123e-139 457.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_1943340_9 237368.SCABRO_00218 9.032e-19 90.0 COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes 203682|Planctomycetes E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS1_k127_1947146_7 379066.GAU_1374 3.612e-73 254.0 28NKC@1|root,2ZBM7@2|Bacteria,1ZUHB@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_1947146_12 1250232.JQNJ01000001_gene1550 1.177e-07 61.0 29UEX@1|root,30FRQ@2|Bacteria,4NNN7@976|Bacteroidetes,1I8KJ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_1947146_1 1499967.BAYZ01000109_gene2987 1.385e-181 581.0 COG0076@1|root,COG0076@2|Bacteria 2|Bacteria E glutamate decarboxylase activity rhbB - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC CMS1_k127_1947146_3 861299.J421_1760 2.765e-154 528.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_1947146_11 247490.KSU1_C0726 1.812e-23 102.0 COG3360@1|root,COG3360@2|Bacteria 2|Bacteria P Dodecin secE2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K09165 - - - - ko00000 - - - Dodecin CMS1_k127_1947146_6 1379270.AUXF01000002_gene1586 8.936e-79 284.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_1947146_9 861299.J421_0303 1.176e-69 244.0 COG3000@1|root,COG3000@2|Bacteria 2|Bacteria I iron ion binding - - - - - - - - - - - - FA_hydroxylase CMS1_k127_1947146_5 1379270.AUXF01000002_gene1163 2.979e-115 381.0 COG3342@1|root,COG3342@2|Bacteria 2|Bacteria S Family of unknown function (DUF1028) fimA - - - - - - - - - - - DUF1028,PG_binding_2 CMS1_k127_1947146_2 945713.IALB_0608 1.309e-170 559.0 COG3591@1|root,COG3591@2|Bacteria 2|Bacteria E Belongs to the peptidase S1B family - - - - - - - - - - - - Peptidase_S46 CMS1_k127_1947146_4 1121957.ATVL01000007_gene1883 1.463e-136 455.0 COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,47M14@768503|Cytophagia 976|Bacteroidetes G Peptidase, M28 PGCP - - - - - - - - - - - Peptidase_M28 CMS1_k127_1947146_0 502025.Hoch_6187 2.763e-260 819.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_1947146_10 1267534.KB906755_gene4820 9.099e-67 241.0 COG1209@1|root,COG1209@2|Bacteria 2|Bacteria M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis GalU - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase CMS1_k127_1947146_8 866536.Belba_0825 9.484e-72 246.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF CMS1_k127_1951866_2 760568.Desku_3099 7.871e-37 161.0 COG5550@1|root,COG5550@2|Bacteria,1W58U@1239|Firmicutes,255IM@186801|Clostridia 186801|Clostridia O TIGRFAM clan AA aspartic protease, AF_0612 family - - - - - - - - - - - - - CMS1_k127_1951866_1 1379270.AUXF01000002_gene1583 9.35e-174 577.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1583|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_1951866_0 1379270.AUXF01000002_gene1585 1.897e-178 594.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_19632_3 1047013.AQSP01000142_gene242 5.706e-130 442.0 COG2511@1|root,COG2511@2|Bacteria 2|Bacteria J GatB/GatE catalytic domain - - - - - - - - - - - - GatB_N CMS1_k127_19632_1 1499683.CCFF01000013_gene324 8.17e-189 612.0 COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,36EB6@31979|Clostridiaceae 186801|Clostridia EJ L-asparaginase - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase CMS1_k127_19632_0 1379270.AUXF01000001_gene2683 7.508e-278 865.0 COG0008@1|root,COG0008@2|Bacteria,1ZTAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (E and Q), anti-codon binding domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C CMS1_k127_19632_2 1379270.AUXF01000003_gene3585 3.77e-133 465.0 COG3653@1|root,COG3653@2|Bacteria,1ZUQ6@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 CMS1_k127_1963367_2 316067.Geob_1099 1.718e-30 135.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,43UDK@69541|Desulfuromonadales 28221|Deltaproteobacteria U Involved in the TonB-independent uptake of proteins tolB GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N CMS1_k127_1963367_1 926554.KI912621_gene1056 4.019e-74 258.0 COG3823@1|root,COG3823@2|Bacteria,1WM89@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M Glutamine cyclotransferase - - 2.3.2.5 ko:K00683 - - - - ko00000,ko01000 - - - Glu_cyclase_2 CMS1_k127_1963367_3 1267534.KB906756_gene149 6.414e-18 87.0 2ESJ3@1|root,33K3T@2|Bacteria,3Y8Y6@57723|Acidobacteria,2JNTF@204432|Acidobacteriia 204432|Acidobacteriia S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM CMS1_k127_1963367_0 379066.GAU_2996 5.248e-123 403.0 COG0656@1|root,COG0656@2|Bacteria,1ZURF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS1_k127_1963367_4 1121272.KB903255_gene5684 4.931e-12 67.0 COG0346@1|root,COG0346@2|Bacteria,2HUMQ@201174|Actinobacteria,4DFH8@85008|Micromonosporales 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase CMS1_k127_198039_0 1380394.JADL01000001_gene2359 8.973e-40 152.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,2JWA5@204441|Rhodospirillales 204441|Rhodospirillales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 CMS1_k127_198039_1 1449063.JMLS01000009_gene2237 3.22e-21 108.0 COG5164@1|root,COG5164@2|Bacteria 2|Bacteria K cell wall organization - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Collagen,Endonuclea_NS_2,Gram_pos_anchor CMS1_k127_1981355_1 1379270.AUXF01000002_gene1600 2.02e-52 205.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_1981355_0 1379270.AUXF01000002_gene1585 1.661e-157 519.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_1987375_1 379066.GAU_2666 2.302e-206 661.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUMT@142182|Gemmatimonadetes 142182|Gemmatimonadetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_1987375_0 379066.GAU_2666 0.0 1225.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUMT@142182|Gemmatimonadetes 142182|Gemmatimonadetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_1987375_5 861299.J421_2048 3.415e-11 66.0 COG0828@1|root,COG0828@2|Bacteria,1ZU81@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S21 - - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 CMS1_k127_1987375_4 379066.GAU_2186 1.941e-32 127.0 COG1278@1|root,COG1278@2|Bacteria,1ZTZ4@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Cold shock protein domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS1_k127_1987375_3 935863.AWZR01000001_gene1972 6.095e-97 329.0 COG5504@1|root,COG5504@2|Bacteria,1RCGT@1224|Proteobacteria,1SXX1@1236|Gammaproteobacteria,1X6Y0@135614|Xanthomonadales 135614|Xanthomonadales O Predicted Zn-dependent protease (DUF2268) - - - - - - - - - - - - DUF2268 CMS1_k127_1987375_2 234267.Acid_0469 6.417e-194 626.0 COG1506@1|root,COG1506@2|Bacteria,3Y3DT@57723|Acidobacteria 57723|Acidobacteria E peptidase S9B dipeptidylpeptidase IV domain protein - - - - - - - - - - - - DPPIV_N,Peptidase_S9 CMS1_k127_2000128_1 1396141.BATP01000003_gene5228 1.272e-119 399.0 COG0451@1|root,COG0451@2|Bacteria,46XPQ@74201|Verrucomicrobia,2IWC3@203494|Verrucomicrobiae 203494|Verrucomicrobiae GM ADP-glyceromanno-heptose 6-epimerase activity - - - - - - - - - - - - - CMS1_k127_2000128_2 861299.J421_1713 3.819e-08 63.0 COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG1629@2|Bacteria,1ZTMF@142182|Gemmatimonadetes 142182|Gemmatimonadetes MP Gram-negative bacterial TonB protein C-terminal - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_C CMS1_k127_2000128_0 861299.J421_4436 5.973e-188 593.0 COG2866@1|root,COG2866@2|Bacteria,1ZSMP@142182|Gemmatimonadetes 2|Bacteria E Zinc carboxypeptidase - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS1_k127_2013674_3 861299.J421_2976 6.158e-91 304.0 COG1657@1|root,COG1657@2|Bacteria,1ZSPV@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 CMS1_k127_2013674_2 861299.J421_2977 1.021e-103 377.0 COG1196@1|root,COG4942@1|root,COG1196@2|Bacteria,COG4942@2|Bacteria,1ZSU8@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - CMS1_k127_2013674_5 861299.J421_2978 3.955e-39 165.0 COG1729@1|root,COG1729@2|Bacteria,1ZTBJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - - CMS1_k127_2013674_1 379066.GAU_1255 6.046e-158 521.0 2CD20@1|root,2Z7SQ@2|Bacteria,1ZTFE@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2013674_0 861299.J421_2981 1.08e-286 906.0 COG1199@1|root,COG2003@1|root,COG1199@2|Bacteria,COG2003@2|Bacteria,1ZT1S@142182|Gemmatimonadetes 142182|Gemmatimonadetes L HELICc2 - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - Helicase_C_2,RadC CMS1_k127_2013674_6 379066.GAU_2121 2.961e-30 129.0 COG0436@1|root,COG0436@2|Bacteria,1ZTCU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class I and II - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_2013674_4 861299.J421_3701 2.56e-88 298.0 COG0436@1|root,COG0436@2|Bacteria,1ZTCU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class I and II - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_2013674_7 861299.J421_2984 6.021e-05 54.0 2FFNT@1|root,347K5@2|Bacteria,1ZTY9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2014890_1 861299.J421_1230 1.103e-197 646.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_2014890_2 1120972.AUMH01000007_gene1617 2.516e-175 559.0 2CA5R@1|root,2Z81H@2|Bacteria,1UYYB@1239|Firmicutes,4HA7J@91061|Bacilli 91061|Bacilli S Domain of unknown function (DUF4153) - - - - - - - - - - - - DUF4153 CMS1_k127_2014890_7 1267535.KB906767_gene1933 5.641e-49 177.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated ywzG - - - - - - - - - - - PadR CMS1_k127_2014890_16 1379270.AUXF01000002_gene1586 4.719e-09 66.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_2014890_14 1121861.KB899912_gene1066 3.498e-14 79.0 COG5455@1|root,COG5455@2|Bacteria,1N3PU@1224|Proteobacteria,2UGK9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S response to cobalt ion - - - - - - - - - - - - - CMS1_k127_2014890_4 215803.DB30_0719 1.265e-106 362.0 COG1167@1|root,COG1167@2|Bacteria,1MUJE@1224|Proteobacteria,42M1Z@68525|delta/epsilon subdivisions,2WJYC@28221|Deltaproteobacteria,2YXXR@29|Myxococcales 28221|Deltaproteobacteria K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - Aminotran_1_2,GntR CMS1_k127_2014890_15 685035.ADAE01000002_gene2111 7.52e-11 68.0 COG2329@1|root,COG2329@2|Bacteria,1Q2JU@1224|Proteobacteria,2UIP8@28211|Alphaproteobacteria,2KDKI@204457|Sphingomonadales 204457|Sphingomonadales S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM CMS1_k127_2014890_3 639030.JHVA01000001_gene3568 9.163e-146 478.0 COG0076@1|root,COG0076@2|Bacteria,3Y3S7@57723|Acidobacteria,2JJ5R@204432|Acidobacteriia 204432|Acidobacteriia E Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC CMS1_k127_2014890_5 1380391.JIAS01000019_gene1349 5.782e-83 284.0 COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,2JRXQ@204441|Rhodospirillales 204441|Rhodospirillales J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 CMS1_k127_2014890_9 384765.SIAM614_26301 8.65e-30 136.0 COG0697@1|root,COG0697@2|Bacteria,1MZ21@1224|Proteobacteria,2UBAQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_2014890_12 1121875.KB907547_gene2909 5.542e-24 105.0 COG1366@1|root,COG1366@2|Bacteria,4NZQX@976|Bacteroidetes 976|Bacteroidetes T STAS domain - - - - - - - - - - - - STAS CMS1_k127_2014890_13 644968.DFW101_0415 1.435e-22 112.0 COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,42V4M@68525|delta/epsilon subdivisions,2WRKJ@28221|Deltaproteobacteria,2MBIZ@213115|Desulfovibrionales 28221|Deltaproteobacteria T anti-sigma regulatory factor, serine threonine protein kinase - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 CMS1_k127_2014890_11 649747.HMPREF0083_05109 3.017e-28 120.0 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,26TDT@186822|Paenibacillaceae 91061|Bacilli K Belongs to the sigma-70 factor family. ECF subfamily sigW - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2014890_17 5482.XP_002551353.1 0.0003683 45.0 29J5E@1|root,2RSDH@2759|Eukaryota,39KTQ@33154|Opisthokonta,3P9KT@4751|Fungi 4751|Fungi - - - - - - - - - - - - - - - CMS1_k127_2014890_0 1123267.JONN01000001_gene1238 8.663e-241 779.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP CMS1_k127_2014890_8 1123267.JONN01000001_gene1239 3.256e-30 140.0 2C1YS@1|root,2ZD2Y@2|Bacteria 2|Bacteria S Protease prsW family - - - - - - - - - - - - PrsW-protease CMS1_k127_2014890_6 1147.D082_01210 8.802e-73 261.0 COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1G3MK@1117|Cyanobacteria,1H64Y@1142|Synechocystis 1117|Cyanobacteria T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - HAMP,HisKA,Response_reg,SpoIIE CMS1_k127_2015784_0 1121405.dsmv_3003 0.0 1225.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria 28221|Deltaproteobacteria G glycosyltransferase 36 associated - - 2.4.1.20 ko:K00702,ko:K13688 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000,ko01003 - GH94,GT36,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase CMS1_k127_2022903_2 794903.OPIT5_22540 8.91e-27 115.0 COG4585@1|root,COG4585@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07683 ko02020,map02020 M00483 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HATPase_c,HATPase_c_2,HisKA_3,PAS,PAS_4,PAS_9 CMS1_k127_2022903_1 192952.MM_1091 2.371e-32 143.0 COG0526@1|root,arCOG07612@2157|Archaea,2Y43J@28890|Euryarchaeota,2NB18@224756|Methanomicrobia 224756|Methanomicrobia O KaiB - - - ko:K08481 - - - - ko00000 - - - KaiB CMS1_k127_2022903_0 316067.Geob_3570 7.956e-149 479.0 COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Pfam:KaiC - - - ko:K08482 - - - - ko00000 - - - ATPase CMS1_k127_2037872_2 861299.J421_2627 4.348e-85 286.0 COG0056@1|root,COG0056@2|Bacteria,1ZSNY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N CMS1_k127_2037872_7 379066.GAU_0713 1.876e-31 143.0 COG2207@1|root,COG2207@2|Bacteria,1ZUCN@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 CMS1_k127_2037872_6 861299.J421_2626 1.484e-50 183.0 COG1051@1|root,COG1051@2|Bacteria,1ZTP5@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NUDIX domain - - - - - - - - - - - - NUDIX CMS1_k127_2037872_3 1379270.AUXF01000007_gene1059 1.405e-72 267.0 COG1463@1|root,COG1463@2|Bacteria,1ZUJC@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS1_k127_2037872_1 379066.GAU_0711 6.253e-91 316.0 COG1127@1|root,COG1127@2|Bacteria,1ZT5N@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran CMS1_k127_2037872_4 379066.GAU_3855 9.135e-71 247.0 COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS1_k127_2037872_0 379066.GAU_0710 1.678e-145 465.0 COG0568@1|root,COG0568@2|Bacteria,1ZTCX@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 CMS1_k127_2037872_13 1121286.AUMT01000002_gene1394 1.002e-07 54.0 2AAAU@1|root,30ZKF@2|Bacteria,4PDWW@976|Bacteroidetes,1IEA8@117743|Flavobacteriia,3ZT19@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_2037872_12 1122165.AUHS01000003_gene1982 2.672e-08 55.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1JEBZ@118969|Legionellales 118969|Legionellales J Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C CMS1_k127_2037872_17 1121091.AUMP01000006_gene4105 4.456e-05 48.0 2DTBP@1|root,33JKJ@2|Bacteria,1VKDH@1239|Firmicutes,4I0AV@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - CMS1_k127_2037872_19 537013.CLOSTMETH_03351 0.0002954 55.0 COG3757@1|root,COG5492@1|root,COG3757@2|Bacteria,COG5492@2|Bacteria,1V2DN@1239|Firmicutes,25BKK@186801|Clostridia,3WS6V@541000|Ruminococcaceae 186801|Clostridia M Glycosyl hydrolases family 25 - - - - - - - - - - - - Glyco_hydro_25 CMS1_k127_2037872_14 1449065.JMLL01000010_gene1657 7.352e-07 62.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,43HWZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N CMS1_k127_2037872_16 1227499.C493_19471 5.531e-06 61.0 arCOG02545@1|root,arCOG04500@1|root,arCOG07560@1|root,arCOG02545@2157|Archaea,arCOG04500@2157|Archaea,arCOG07560@2157|Archaea,2Y7XT@28890|Euryarchaeota,23Y9T@183963|Halobacteria 183963|Halobacteria S Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - Beta_helix,NosD CMS1_k127_2037872_15 1379270.AUXF01000005_gene316 5.46e-06 59.0 COG5492@1|root,COG5492@2|Bacteria 2|Bacteria N domain, Protein ligA1 - - - - - - - - - - - Big_2 CMS1_k127_2037872_8 1089550.ATTH01000001_gene1532 6.391e-31 137.0 COG1462@1|root,COG1462@2|Bacteria 2|Bacteria M curli production assembly transport component CsgG - - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - CsgG,FlgT_C CMS1_k127_2037872_5 671143.DAMO_2078 6.43e-57 213.0 COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 CMS1_k127_2037872_10 861299.J421_2622 8.855e-10 61.0 COG1158@1|root,COG1158@2|Bacteria,1ZSXH@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind CMS1_k127_2067244_3 1379270.AUXF01000006_gene315 2.17e-72 252.0 COG1159@1|root,COG1159@2|Bacteria,1ZUSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 CMS1_k127_2067244_6 1125863.JAFN01000001_gene531 3.441e-17 93.0 COG2835@1|root,COG2835@2|Bacteria,1Q1BG@1224|Proteobacteria,42WTN@68525|delta/epsilon subdivisions,2WSI9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p CMS1_k127_2067244_7 518766.Rmar_2396 0.0001462 53.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - CMS1_k127_2067244_4 1379270.AUXF01000006_gene313 7.774e-50 198.0 2BXP0@1|root,34268@2|Bacteria,1ZTVK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2067244_2 1379270.AUXF01000006_gene312 3.035e-89 304.0 COG2199@1|root,COG2199@2|Bacteria,1ZT1F@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF CMS1_k127_2067244_5 861299.J421_3210 7.141e-32 139.0 2F3JX@1|root,33WDB@2|Bacteria,1ZTZI@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - zinc_ribbon_4 CMS1_k127_2067244_1 861299.J421_3211 4.48e-131 427.0 COG1186@1|root,COG1186@2|Bacteria,1ZTE4@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 CMS1_k127_2067244_0 379066.GAU_1579 7.175e-160 518.0 COG1190@1|root,COG1190@2|Bacteria,1ZT9X@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class II (D, K and N) lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon CMS1_k127_2079752_2 1166130.H650_23755 5.615e-16 80.0 COG0300@1|root,COG0300@2|Bacteria,1MWNZ@1224|Proteobacteria,1RS01@1236|Gammaproteobacteria,3X1CP@547|Enterobacter 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short CMS1_k127_2079752_1 1353531.AZNX01000008_gene774 5.523e-123 404.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria,4BC24@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - - - - - - - - - - DJ-1_PfpI,HTH_18 CMS1_k127_2079752_0 1432050.IE4771_CH01154 5.533e-155 518.0 COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,2TVNH@28211|Alphaproteobacteria,4B8Y7@82115|Rhizobiaceae 28211|Alphaproteobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_31 CMS1_k127_2079752_3 1122919.KB905589_gene4112 6.82e-13 68.0 COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,4HBME@91061|Bacilli,26SSJ@186822|Paenibacillaceae 91061|Bacilli G Quinoprotein glucose dehydrogenase gdhB - - - - - - - - - - - GSDH CMS1_k127_2080391_2 1094184.KWO_0118760 4.661e-117 379.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1X3CQ@135614|Xanthomonadales 135614|Xanthomonadales E Transporter yhiP - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 CMS1_k127_2080391_3 861299.J421_2984 1.509e-05 56.0 2FFNT@1|root,347K5@2|Bacteria,1ZTY9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2080391_1 379066.GAU_2121 1.139e-127 425.0 COG0436@1|root,COG0436@2|Bacteria,1ZTCU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class I and II - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_2080391_0 861299.J421_2981 5.818e-284 895.0 COG1199@1|root,COG2003@1|root,COG1199@2|Bacteria,COG2003@2|Bacteria,1ZT1S@142182|Gemmatimonadetes 142182|Gemmatimonadetes L HELICc2 - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - Helicase_C_2,RadC CMS1_k127_2082386_0 861299.J421_1760 1.483e-188 627.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2082386_2 1120949.KB903341_gene9738 5.619e-08 61.0 COG4191@1|root,COG4191@2|Bacteria,2IF7B@201174|Actinobacteria,4DH3U@85008|Micromonosporales 201174|Actinobacteria T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,Response_reg CMS1_k127_2082386_1 861299.J421_3045 7.941e-12 77.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 861299.J421_3045|- KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_2084152_3 1379270.AUXF01000002_gene1589 1.233e-135 436.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_2084152_4 861299.J421_0887 1.158e-105 376.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2084152_0 1379270.AUXF01000002_gene1600 5.617e-255 814.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_2084152_1 1379270.AUXF01000002_gene1585 1.26e-204 668.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_2084152_5 251221.35214080 3.207e-72 258.0 COG1680@1|root,COG1680@2|Bacteria,1G434@1117|Cyanobacteria 1117|Cyanobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_2084152_2 1379270.AUXF01000002_gene1585 3.404e-164 546.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_2089314_2 1121106.JQKB01000018_gene4954 1.854e-08 57.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQSU@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase/oxoprolinase - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A CMS1_k127_2089314_0 1499967.BAYZ01000084_gene3995 2.067e-63 239.0 COG0815@1|root,COG0815@2|Bacteria,2NP0R@2323|unclassified Bacteria 2|Bacteria M Carbon-nitrogen hydrolase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase CMS1_k127_2089314_1 379066.GAU_1177 1.968e-17 84.0 COG0673@1|root,COG0673@2|Bacteria,1ZSV9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Homoserine dehydrogenase, NAD binding domain - - - - - - - - - - - - GFO_IDH_MocA CMS1_k127_2112831_8 1379270.AUXF01000005_gene601 6.259e-19 88.0 2E5IJ@1|root,3309Y@2|Bacteria,1ZTU3@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2112831_7 861299.J421_3007 1.101e-25 111.0 2EQ8R@1|root,33HV0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_2112831_2 861299.J421_3008 4.399e-69 259.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1ZTAT@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N CMS1_k127_2112831_5 1379270.AUXF01000005_gene603 1.08e-46 191.0 COG3292@1|root,COG3292@2|Bacteria,1ZUSW@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Two component regulator propeller - - - - - - - - - - - - - CMS1_k127_2112831_3 861299.J421_3009 2.094e-58 230.0 COG0611@1|root,COG0611@2|Bacteria,1ZTIU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS1_k127_2112831_6 861299.J421_3010 3.464e-46 175.0 COG0204@1|root,COG0204@2|Bacteria,1ZT6D@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase CMS1_k127_2112831_12 190486.XAC0068 0.0002978 53.0 COG1216@1|root,COG1216@2|Bacteria,1N5RX@1224|Proteobacteria,1SH90@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised nucleotidyltransferase - - - - - - - - - - - - NTP_transf_5 CMS1_k127_2112831_1 1379270.AUXF01000001_gene2556 1.26e-96 336.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000001_gene2556|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_2112831_4 316274.Haur_1664 1.245e-50 196.0 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_2112831_9 66875.JODY01000003_gene3398 1.03e-14 79.0 COG1725@1|root,COG1725@2|Bacteria,2IHTD@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR CMS1_k127_2112831_0 861299.J421_3011 2.372e-187 593.0 COG0148@1|root,COG0148@2|Bacteria,1ZTAB@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N CMS1_k127_2112831_10 861299.J421_3012 1.307e-07 61.0 COG2919@1|root,COG2919@2|Bacteria,1ZU6R@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Septum formation initiator - - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC CMS1_k127_2112831_11 450851.PHZ_c2869 6.825e-07 53.0 COG1266@1|root,COG1266@2|Bacteria,1NXKQ@1224|Proteobacteria 1224|Proteobacteria S CAAX protease self-immunity - - - - - - - - - - - - Abi CMS1_k127_2137652_4 1379270.AUXF01000003_gene3855 2.784e-34 152.0 COG0316@1|root,COG0316@2|Bacteria,1ZTT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulphur cluster biosynthesis - - - - - - - - - - - - Fe-S_biosyn CMS1_k127_2137652_0 518766.Rmar_0925 5.332e-118 415.0 COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,1FJ9E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C CMS1_k127_2137652_1 379066.GAU_1999 1.706e-94 325.0 COG3876@1|root,COG3876@2|Bacteria,1ZUBN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF1343) - - - - - - - - - - - - DUF1343 CMS1_k127_2137652_3 446466.Cfla_1785 2.494e-34 145.0 COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4F1PW@85016|Cellulomonadaceae 201174|Actinobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA1 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 ko:K00995,ko:K00999 ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070 - R01801,R01802 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf CMS1_k127_2137652_2 861299.J421_3601 1.23e-81 288.0 COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 CMS1_k127_2146716_0 1121920.AUAU01000002_gene1986 4.87e-171 562.0 COG1529@1|root,COG1529@2|Bacteria,3Y35Q@57723|Acidobacteria 57723|Acidobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 CMS1_k127_2146716_1 118166.JH976537_gene2419 2.537e-114 376.0 28NY3@1|root,2ZBVC@2|Bacteria,1G5MR@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS1_k127_2146716_2 203122.Sde_1823 4.011e-39 151.0 COG0545@1|root,COG0545@2|Bacteria 2|Bacteria O Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802,ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N CMS1_k127_2146716_3 530564.Psta_3947 1.576e-11 66.0 COG0515@1|root,COG0515@2|Bacteria,2IXG3@203682|Planctomycetes 203682|Planctomycetes KLT Serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2194121_0 497965.Cyan7822_1559 1.276e-111 376.0 COG0579@1|root,COG0579@2|Bacteria,1G0XV@1117|Cyanobacteria,3KGD3@43988|Cyanothece 1117|Cyanobacteria S PFAM FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO CMS1_k127_2194121_1 700598.Niako_2683 4.565e-14 78.0 COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1IU6R@117747|Sphingobacteriia 976|Bacteroidetes J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP CMS1_k127_2238704_16 1379270.AUXF01000006_gene180 8.838e-24 103.0 COG1884@1|root,COG1884@2|Bacteria,1ZUKS@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Methylmalonyl-CoA mutase - - 5.4.99.13,5.4.99.2 ko:K01848,ko:K11942 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase CMS1_k127_2238704_11 224324.aq_199 3.978e-52 201.0 COG1503@1|root,COG1503@2|Bacteria 2|Bacteria J translation release factor activity yocB GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - - CMS1_k127_2238704_9 379066.GAU_1708 4.679e-60 210.0 COG2185@1|root,COG2185@2|Bacteria,1ZTNN@142182|Gemmatimonadetes 142182|Gemmatimonadetes I B12 binding domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding CMS1_k127_2238704_0 1379270.AUXF01000006_gene184 1.959e-248 783.0 COG4799@1|root,COG4799@2|Bacteria,1ZTGB@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans CMS1_k127_2238704_7 517418.Ctha_2103 2.177e-80 305.0 COG1404@1|root,COG1404@2|Bacteria,1FEZ9@1090|Chlorobi 1090|Chlorobi O Subtilase family - - - - - - - - - - - - Peptidase_S8 CMS1_k127_2238704_1 861299.J421_3345 1.554e-199 672.0 COG3185@1|root,COG3185@2|Bacteria,1ZT5D@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA CMS1_k127_2238704_12 861299.J421_3344 9.564e-45 164.0 2CIU6@1|root,32S8H@2|Bacteria,1ZTUM@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2238704_10 1330700.JQNC01000003_gene960 1.16e-53 199.0 COG1024@1|root,COG1024@2|Bacteria,1WIUH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I enoyl-CoA hydratase isomerase family - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_2238704_8 1379270.AUXF01000002_gene1586 2.915e-73 267.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_2238704_5 1089550.ATTH01000001_gene138 8.75e-93 321.0 COG0514@1|root,COG0514@2|Bacteria,4NEFD@976|Bacteroidetes,1FJ0B@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L RecQ zinc-binding recQ2 - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecQ_Zn_bind CMS1_k127_2238704_6 1254432.SCE1572_19815 9.758e-90 311.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2YZNI@29|Myxococcales 28221|Deltaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD,SDH_sah CMS1_k127_2238704_3 572479.Hprae_0653 6.995e-130 435.0 COG4864@1|root,COG4864@2|Bacteria,1TPTD@1239|Firmicutes,24APU@186801|Clostridia,3WBA5@53433|Halanaerobiales 186801|Clostridia S SigmaW regulon antibacterial - - - - - - - - - - - - YdfA_immunity CMS1_k127_2238704_2 861299.J421_3340 4.188e-167 539.0 COG1960@1|root,COG1960@2|Bacteria,1ZSVZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K18244 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_2238704_4 1191523.MROS_1725 1.657e-124 417.0 COG1530@1|root,COG1530@2|Bacteria 2|Bacteria J ribonuclease E activity rng - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 CMS1_k127_2238704_15 861299.J421_3337 3.259e-26 111.0 COG0261@1|root,COG0261@2|Bacteria,1ZTS8@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p CMS1_k127_2238704_13 1173029.JH980292_gene43 1.049e-36 142.0 COG0211@1|root,COG0211@2|Bacteria,1G7RW@1117|Cyanobacteria,1HCCX@1150|Oscillatoriales 1117|Cyanobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 CMS1_k127_2238704_14 1379270.AUXF01000001_gene2554 1.273e-30 126.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2277819_5 861299.J421_0588 1.314e-140 457.0 COG4447@1|root,COG4447@2|Bacteria,1ZSRH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 CMS1_k127_2277819_20 1408473.JHXO01000005_gene1870 1.197e-51 197.0 COG0492@1|root,COG0492@2|Bacteria,4NNAA@976|Bacteroidetes,2FXF6@200643|Bacteroidia 976|Bacteroidetes O ferredoxin-NADP+ reductase activity - - - - - - - - - - - - - CMS1_k127_2277819_13 404589.Anae109_2645 3.864e-106 375.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,4397N@68525|delta/epsilon subdivisions,2X4EI@28221|Deltaproteobacteria,2YYVA@29|Myxococcales 28221|Deltaproteobacteria C heat shock protein binding - - - - - - - - - - - - Cytochrome_C7 CMS1_k127_2277819_16 1408473.JHXO01000005_gene1865 1.582e-87 310.0 COG0484@1|root,COG0484@2|Bacteria,4NPS0@976|Bacteroidetes,2FXKU@200643|Bacteroidia 976|Bacteroidetes O heat shock protein binding - - - - - - - - - - - - - CMS1_k127_2277819_9 1502850.FG91_00925 1.376e-120 422.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PR9I@1224|Proteobacteria,2U1SM@28211|Alphaproteobacteria,2K253@204457|Sphingomonadales 204457|Sphingomonadales C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_4,Pyr_redox_3 CMS1_k127_2277819_17 929556.Solca_3116 3.27e-76 286.0 COG1835@1|root,COG1835@2|Bacteria,4NMNZ@976|Bacteroidetes,1IQXU@117747|Sphingobacteriia 976|Bacteroidetes I Domain of unknown function (DUF4153) - - - - - - - - - - - - DUF4153 CMS1_k127_2277819_2 314278.NB231_00435 4.843e-185 585.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C6@1236|Gammaproteobacteria,1WXH4@135613|Chromatiales 135613|Chromatiales C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM CMS1_k127_2277819_0 1121422.AUMW01000026_gene381 1.109e-209 664.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,26131@186807|Peptococcaceae 186801|Clostridia C Belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8,1.2.1.99 ko:K00130,ko:K00135,ko:K09472,ko:K22187 ko00040,ko00250,ko00260,ko00310,ko00330,ko00350,ko00650,ko00760,ko01100,ko01120,map00040,map00250,map00260,map00310,map00330,map00350,map00650,map00760,map01100,map01120 M00027,M00136,M00555 R00713,R00714,R02401,R02565,R02566,R07417,R07418,R11768 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS1_k127_2277819_3 882083.SacmaDRAFT_2583 3.843e-152 496.0 COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4EBQT@85010|Pseudonocardiales 201174|Actinobacteria P Sulfate permease family - - - - - - - - - - - - STAS,Sulfate_transp CMS1_k127_2277819_12 1379698.RBG1_1C00001G0813 6.361e-112 376.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red CMS1_k127_2277819_23 491916.RHECIAT_CH0001431 5.54e-30 125.0 COG4852@1|root,COG4852@2|Bacteria,1MZHP@1224|Proteobacteria,2USZ7@28211|Alphaproteobacteria,4BFGK@82115|Rhizobiaceae 28211|Alphaproteobacteria S Predicted membrane protein (DUF2177) - - - - - - - - - - - - DUF2177 CMS1_k127_2277819_1 518766.Rmar_1178 1.347e-192 623.0 COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,1FJT8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase S46 dpp7 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_S46 CMS1_k127_2277819_21 1122185.N792_07405 4.137e-51 193.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,1X4MM@135614|Xanthomonadales 135614|Xanthomonadales O peptidylprolyl - - 5.2.1.8 ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N CMS1_k127_2277819_22 644966.Tmar_0475 2.44e-34 143.0 COG1309@1|root,COG1309@2|Bacteria,1V3QD@1239|Firmicutes,25BU1@186801|Clostridia,3WDJR@538999|Clostridiales incertae sedis 186801|Clostridia K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS1_k127_2277819_10 85643.Tmz1t_2954 4.251e-115 391.0 COG1064@1|root,COG1064@2|Bacteria,1QVIH@1224|Proteobacteria,2VP5E@28216|Betaproteobacteria,2KVHQ@206389|Rhodocyclales 28216|Betaproteobacteria C Zinc-binding dehydrogenase - - 1.1.1.368 ko:K07538 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05581 RC00850 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_2277819_4 1187851.A33M_3194 1.487e-147 475.0 COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.21 ko:K07539 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05593,R05594,R10696 RC01430,RC01431,RC03237 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_2277819_15 316067.Geob_0099 4.47e-89 300.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_2277819_7 706587.Desti_2452 4.665e-123 405.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_2277819_24 909663.KI867150_gene1036 8.71e-26 111.0 COG1545@1|root,COG1545@2|Bacteria,1N4S9@1224|Proteobacteria,42U3D@68525|delta/epsilon subdivisions,2WQNA@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc CMS1_k127_2277819_19 76114.ebA5296 2.543e-52 194.0 COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,2VUI3@28216|Betaproteobacteria,2KWVM@206389|Rhodocyclales 206389|Rhodocyclales I Enoyl-CoA hydratase/isomerase dch - 4.2.1.100 ko:K07537 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05597 RC03168 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_2277819_11 398767.Glov_2401 1.602e-114 383.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D CMS1_k127_2277819_8 398767.Glov_2400 1.896e-122 414.0 COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,430HE@68525|delta/epsilon subdivisions,2WVZI@28221|Deltaproteobacteria,43V4N@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D CMS1_k127_2277819_14 398767.Glov_2399 6.006e-95 320.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales 28221|Deltaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family yjiL - - - - - - - - - - - BcrAD_BadFG CMS1_k127_2277819_18 398767.Glov_2398 5.4e-65 232.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42R04@68525|delta/epsilon subdivisions,2WMZ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM ATPase, BadF BadG BcrA BcrD type - - - - - - - - - - - - BcrAD_BadFG CMS1_k127_2277819_25 1207063.P24_18854 6.266e-16 89.0 COG0457@1|root,COG0457@2|Bacteria,1QZ3F@1224|Proteobacteria,2TY48@28211|Alphaproteobacteria,2JQQM@204441|Rhodospirillales 204441|Rhodospirillales Q Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 CMS1_k127_2277819_6 1379698.RBG1_1C00001G0513 3.104e-135 442.0 COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria 2|Bacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA3 - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like CMS1_k127_2277819_26 1297742.A176_02903 1.006e-14 76.0 COG3193@1|root,COG3193@2|Bacteria,1QX6Y@1224|Proteobacteria,43BZP@68525|delta/epsilon subdivisions,2X7AG@28221|Deltaproteobacteria,2YU0D@29|Myxococcales 28221|Deltaproteobacteria S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD_RagB CMS1_k127_229872_1 177437.HRM2_09160 3.044e-112 370.0 COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2MHQP@213118|Desulfobacterales 28221|Deltaproteobacteria GM Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867,NAD_binding_10 CMS1_k127_229872_2 84531.JMTZ01000010_gene3141 1.844e-71 252.0 2DCFR@1|root,2ZDYQ@2|Bacteria,1RB5X@1224|Proteobacteria,1RN4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_229872_0 1191523.MROS_2800 7.297e-213 670.0 COG0334@1|root,COG0334@2|Bacteria 2|Bacteria E glutamate dehydrogenase [NAD(P)+] activity gluD GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.gdhA ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_233292_0 1278073.MYSTI_04090 8.122e-40 164.0 COG3568@1|root,COG3568@2|Bacteria,1N29G@1224|Proteobacteria,438Z7@68525|delta/epsilon subdivisions,2X8PT@28221|Deltaproteobacteria,2YY8K@29|Myxococcales 28221|Deltaproteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos CMS1_k127_2340064_4 1158318.ATXC01000001_gene182 7.575e-11 62.0 COG0543@1|root,COG0543@2|Bacteria,2G45B@200783|Aquificae 200783|Aquificae C Oxidoreductase NAD-binding domain - - - - - - - - - - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 CMS1_k127_2340064_3 374847.Kcr_0322 2.27e-58 211.0 COG1941@1|root,arCOG02472@2157|Archaea 2157|Archaea C PFAM NADH ubiquinone oxidoreductase 20 kDa subunit - - 1.12.1.3,1.12.1.5 ko:K17994 ko00920,map00920 - R10390 - ko00000,ko00001,ko01000 - - - Oxidored_q6 CMS1_k127_2340064_1 374847.Kcr_0321 1.682e-87 310.0 COG0374@1|root,arCOG01549@2157|Archaea 2157|Archaea C Belongs to the NiFe NiFeSe hydrogenase large subunit family hydA GO:0003674,GO:0005488,GO:0005575,GO:0016151,GO:0032991,GO:0043167,GO:0043169,GO:0044569,GO:0046872,GO:0046914,GO:1902494 1.12.1.3,1.12.1.5,1.8.98.5 ko:K14126,ko:K17993 ko00680,ko00920,map00680,map00920 - R00019,R10390,R11943 RC00011 ko00000,ko00001,ko01000 - - - NiFeSe_Hases CMS1_k127_2340064_0 269799.Gmet_1057 2.503e-123 419.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase HAMP - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 CMS1_k127_2340064_2 1206739.BAGJ01000259_gene5289 1.037e-62 219.0 COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4FTY3@85025|Nocardiaceae 201174|Actinobacteria O AIR synthase related protein, C-terminal domain hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C CMS1_k127_2388267_0 379066.GAU_2847 4.035e-33 133.0 2ARQH@1|root,31H1J@2|Bacteria,1ZUJU@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Phosphodiester glycosidase - - - - - - - - - - - - NAGPA CMS1_k127_239161_14 234267.Acid_7572 5.052e-61 229.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS1_k127_239161_2 1168289.AJKI01000002_gene2490 3.168e-185 587.0 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,4NFUN@976|Bacteroidetes,2FNNY@200643|Bacteroidia,3XIRJ@558415|Marinilabiliaceae 976|Bacteroidetes S Nucleoside recognition spmA - - ko:K06373 - - - - ko00000 - - - Gate CMS1_k127_239161_12 998674.ATTE01000001_gene3159 6.834e-65 240.0 COG2866@1|root,COG2866@2|Bacteria,1N9AY@1224|Proteobacteria,1RRGU@1236|Gammaproteobacteria,4625I@72273|Thiotrichales 72273|Thiotrichales E Zn_pept - - - - - - - - - - - - Peptidase_M14 CMS1_k127_239161_11 1279017.AQYJ01000024_gene887 1.307e-70 246.0 COG1876@1|root,COG1876@2|Bacteria,1N2IC@1224|Proteobacteria,1S0DU@1236|Gammaproteobacteria,4679R@72275|Alteromonadaceae 1236|Gammaproteobacteria M D-alanyl-D-alanine carboxypeptidase vanY - - - - - - - - - - - VanY CMS1_k127_239161_7 861299.J421_0887 6.126e-95 343.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_239161_13 420324.KI912044_gene3937 1.609e-63 233.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,1JRQD@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Peptidase dimerisation domain - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS1_k127_239161_5 880073.Calab_2517 5.131e-138 450.0 COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria 2|Bacteria E Cys/Met metabolism PLP-dependent enzyme - - 2.5.1.48,4.4.1.11,4.4.1.8 ko:K01739,ko:K01760,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP CMS1_k127_239161_4 309807.SRU_0271 7.934e-148 483.0 COG1409@1|root,COG1409@2|Bacteria,4NF9K@976|Bacteroidetes 976|Bacteroidetes C PFAM Calcineurin-like phosphoesterase - - - - - - - - - - - - DUF4985,GHL10,Metallophos,MetallophosC,MetallophosN CMS1_k127_239161_6 1121272.KB903251_gene666 1.053e-103 359.0 COG1404@1|root,COG2866@1|root,COG1404@2|Bacteria,COG2866@2|Bacteria,2GJYH@201174|Actinobacteria,4DBUI@85008|Micromonosporales 201174|Actinobacteria M Peptidase inhibitor I9 - - - - - - - - - - - - Inhibitor_I9,P_proprotein,Peptidase_S8 CMS1_k127_239161_9 394221.Mmar10_0675 3.683e-92 317.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,2TUAV@28211|Alphaproteobacteria,43ZIZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_239161_8 331869.BAL199_14437 3.267e-93 313.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,2U3UR@28211|Alphaproteobacteria,4BR6M@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like CMS1_k127_239161_1 1122135.KB893135_gene1033 2.699e-213 687.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TWVC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL CMS1_k127_239161_17 1996.JOFO01000008_gene3274 1.562e-34 140.0 COG1309@1|root,COG1309@2|Bacteria,2GJPK@201174|Actinobacteria,4EIUM@85012|Streptosporangiales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_C_6,TetR_N CMS1_k127_239161_10 926560.KE387023_gene1700 2.056e-85 306.0 COG3437@1|root,COG3852@1|root,COG3437@2|Bacteria,COG3852@2|Bacteria,1WMD2@1297|Deinococcus-Thermus 2|Bacteria T Histidine kinase-like ATPases pleD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65,4.6.1.1 ko:K01768,ko:K02488,ko:K17763 ko00230,ko02020,ko02025,ko04112,ko04113,ko04213,map00230,map02020,map02025,map04112,map04113,map04213 M00511,M00695 R00089,R00434,R08057 RC00295 ko00000,ko00001,ko00002,ko01000,ko02022,ko03021 - - - GGDEF,HATPase_c,HisKA,HisKA_3,PAS,PAS_9,Response_reg,cNMP_binding CMS1_k127_239161_21 1122222.AXWR01000013_gene961 1.919e-06 58.0 COG1520@1|root,COG2706@1|root,COG3291@1|root,COG1520@2|Bacteria,COG2706@2|Bacteria,COG3291@2|Bacteria,1WKKN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus N Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - Big_2,SBBP CMS1_k127_239161_19 1484460.JSWG01000012_gene1276 8.539e-22 113.0 COG0631@1|root,COG5295@1|root,COG0631@2|Bacteria,COG5295@2|Bacteria,4PM4Q@976|Bacteroidetes,1IJVM@117743|Flavobacteriia 976|Bacteroidetes UW Head domain of trimeric autotransporter adhesin - - - - - - - - - - - - Peptidase_S74,YadA_head CMS1_k127_239161_15 1137281.D778_01491 6.481e-53 216.0 COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4PKW4@976|Bacteroidetes,1I1PS@117743|Flavobacteriia 976|Bacteroidetes MUW Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74,YadA_head CMS1_k127_239161_3 1089550.ATTH01000001_gene1831 4.128e-165 554.0 COG0515@1|root,COG0515@2|Bacteria,4NPN9@976|Bacteroidetes,1FJI6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - NERD,Pkinase,TPR_12,TPR_8 CMS1_k127_239161_16 234267.Acid_7677 1.508e-52 193.0 COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria 57723|Acidobacteria K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF CMS1_k127_239161_0 518766.Rmar_2049 0.0 1092.0 COG1506@1|root,COG2706@1|root,COG1506@2|Bacteria,COG2706@2|Bacteria,4PIC9@976|Bacteroidetes,1FKAR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E 6-phosphogluconolactonase activity - - - - - - - - - - - - - CMS1_k127_239161_20 670487.Ocepr_2073 8.983e-16 78.0 COG2872@1|root,COG2872@2|Bacteria,1WIB4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain - - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS1_k127_2408879_0 1379270.AUXF01000002_gene1600 1.321e-149 504.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_2408879_1 861299.J421_6371 1.268e-134 449.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6371|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_2414625_3 861299.J421_4135 3.024e-79 293.0 COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2414625_2 861299.J421_5759 5.759e-165 546.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2414625_4 926560.KE387023_gene1527 9.792e-39 156.0 COG1917@1|root,COG1917@2|Bacteria,1WMIY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - CMS1_k127_2414625_5 861299.J421_1300 2.657e-29 124.0 COG1278@1|root,COG1278@2|Bacteria,1ZTZ4@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Cold shock protein domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS1_k127_2414625_1 861299.J421_4258 2.063e-169 545.0 COG0513@1|root,COG0513@2|Bacteria,1ZT7G@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DEAD-like helicases superfamily - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C CMS1_k127_2414625_6 344747.PM8797T_25016 1.5e-21 104.0 2E2CP@1|root,32XHN@2|Bacteria,2J0IA@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS1_k127_2414625_0 1244869.H261_06576 1.324e-202 651.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales 204441|Rhodospirillales C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM CMS1_k127_2414625_7 1458427.BAWN01000006_gene358 1.038e-09 60.0 2DNSI@1|root,32YXC@2|Bacteria,1N7K2@1224|Proteobacteria,2VVXF@28216|Betaproteobacteria,4AFCE@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_2416705_2 234267.Acid_6833 1.277e-06 60.0 COG0823@1|root,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria 57723|Acidobacteria KU WD40 domain protein beta Propeller - - - - - - - - - - - - PD40,Trans_reg_C CMS1_k127_2416705_0 1442599.JAAN01000035_gene641 3.897e-121 413.0 COG1228@1|root,COG1228@2|Bacteria,1RCA0@1224|Proteobacteria,1S08B@1236|Gammaproteobacteria,1X5NR@135614|Xanthomonadales 135614|Xanthomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,CIA30 CMS1_k127_2416705_1 671143.DAMO_2175 3.681e-08 56.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase CMS1_k127_242553_0 1379270.AUXF01000004_gene3163 7.502e-112 390.0 COG0457@1|root,COG0457@2|Bacteria 1379270.AUXF01000004_gene3163|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_242553_1 867845.KI911784_gene3392 1.374e-36 147.0 COG1651@1|root,COG1651@2|Bacteria,2G8TG@200795|Chloroflexi,375RW@32061|Chloroflexia 32061|Chloroflexia O PFAM DSBA oxidoreductase - - - - - - - - - - - - Thioredoxin_4 CMS1_k127_242553_3 861299.J421_1746 1.01e-27 130.0 2CKIA@1|root,345C4@2|Bacteria,1ZV3S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4397) - - - - - - - - - - - - DUF4397 CMS1_k127_242553_4 379066.GAU_0722 5.803e-12 77.0 28Y4A@1|root,2ZJZS@2|Bacteria,1ZV7B@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_242553_2 861299.J421_1744 2.47e-34 138.0 2F03J@1|root,33T76@2|Bacteria,1ZUN0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Pfam:SusD - - - - - - - - - - - - SusD_RagB CMS1_k127_2580594_4 1382306.JNIM01000001_gene3139 1.49e-60 232.0 COG1874@1|root,COG1874@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Cellulase,Glyco_hydro_35,Glyco_hydro_42,Glyco_hydro_42M,Glyco_hydro_cc,Tail_P2_I CMS1_k127_2580594_7 1379270.AUXF01000003_gene3490 5.201e-37 147.0 COG0622@1|root,COG0622@2|Bacteria,1ZTSV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 CMS1_k127_2580594_2 1379270.AUXF01000003_gene3485 1.639e-84 289.0 COG0500@1|root,COG2226@2|Bacteria,1ZSNE@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran CMS1_k127_2580594_3 379066.GAU_2442 3.639e-78 265.0 COG1595@1|root,COG1595@2|Bacteria,1ZT3B@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2580594_9 861299.J421_3910 4.427e-15 89.0 COG1664@1|root,COG1664@2|Bacteria 2|Bacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin CMS1_k127_2580594_10 1382305.AZUC01000006_gene1431 0.0005996 51.0 COG4758@1|root,COG4758@2|Bacteria,1V9SU@1239|Firmicutes,4HJWC@91061|Bacilli 91061|Bacilli S N-terminal domain of toast_rack, DUF2154 - - - - - - - - - - - - DUF2154,Toast_rack_N CMS1_k127_2580594_5 1379270.AUXF01000002_gene1136 1.614e-48 187.0 COG1137@1|root,COG1137@2|Bacteria 2|Bacteria S lipopolysaccharide-transporting ATPase activity - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran CMS1_k127_2580594_6 1166018.FAES_4865 5.692e-46 171.0 COG2318@1|root,COG2318@2|Bacteria,4NQBY@976|Bacteroidetes,47PR7@768503|Cytophagia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_2580594_8 926550.CLDAP_28250 1.145e-30 131.0 COG3439@1|root,COG3439@2|Bacteria,2G72I@200795|Chloroflexi 200795|Chloroflexi S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 CMS1_k127_2580594_0 404589.Anae109_3731 2.122e-195 646.0 COG4775@1|root,COG4775@2|Bacteria 2|Bacteria M membrane organization - - - - - - - - - - - - Bac_surface_Ag,CarboxypepD_reg,Laminin_G_3,POTRA CMS1_k127_2580594_1 1254432.SCE1572_02795 9.567e-106 363.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS1_k127_2604753_7 338969.Rfer_3144 7.382e-61 227.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2604753_11 526222.Desal_2903 3.391e-42 160.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC CMS1_k127_2604753_12 62928.azo2959 3.682e-13 75.0 COG0599@1|root,COG0599@2|Bacteria,1P85X@1224|Proteobacteria,2W5YK@28216|Betaproteobacteria 28216|Betaproteobacteria S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD CMS1_k127_2604753_10 1484460.JSWG01000006_gene2967 2.431e-48 189.0 COG1266@1|root,COG1266@2|Bacteria,4NGBZ@976|Bacteroidetes,1HZ6J@117743|Flavobacteriia 976|Bacteroidetes S CAAX protease self-immunity - - - - - - - - - - - - Abi CMS1_k127_2604753_6 1379270.AUXF01000001_gene1925 3.775e-82 291.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K17285 - - - - ko00000,ko04147 - - - SBP56,SHD1 CMS1_k127_2604753_1 671143.DAMO_1208 6.988e-255 805.0 COG0365@1|root,COG0365@2|Bacteria,2NNSQ@2323|unclassified Bacteria 2|Bacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acs - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS1_k127_2604753_4 861299.J421_0566 5.559e-141 478.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_0566|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_2604753_0 237368.SCABRO_03209 0.0 1479.0 COG0243@1|root,COG1104@1|root,COG0243@2|Bacteria,COG1104@2|Bacteria,2J1TP@203682|Planctomycetes 203682|Planctomycetes CE Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Aminotran_5,Molybdopterin,Molydop_binding CMS1_k127_2604753_2 379066.GAU_0964 2.52e-197 627.0 COG0514@1|root,COG0514@2|Bacteria,1ZUBS@142182|Gemmatimonadetes 142182|Gemmatimonadetes L RecQ zinc-binding - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RecQ_Zn_bind CMS1_k127_2604753_8 1121468.AUBR01000005_gene22 3.985e-59 224.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales 186801|Clostridia E PFAM aminotransferase, class I aspB - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS06550 Aminotran_1_2 CMS1_k127_2604753_9 1111069.TCCBUS3UF1_12200 2.293e-58 213.0 COG0157@1|root,COG0157@2|Bacteria,1WIHZ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N CMS1_k127_2604753_5 309801.trd_0596 8.83e-113 379.0 COG0379@1|root,COG0379@2|Bacteria,2G64Y@200795|Chloroflexi,27Z0R@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA CMS1_k127_2604753_3 234267.Acid_3699 1.414e-154 501.0 COG2355@1|root,COG2355@2|Bacteria,3Y7FK@57723|Acidobacteria 57723|Acidobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 CMS1_k127_2613851_3 448385.sce5490 2.057e-21 97.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WJ41@28221|Deltaproteobacteria,2YUJJ@29|Myxococcales 28221|Deltaproteobacteria S ABC transporter, ATP-binding protein ybiT - - - - - - - - - - - ABC_tran,ABC_tran_Xtn CMS1_k127_2613851_0 713586.KB900536_gene1543 4.385e-42 176.0 COG3055@1|root,COG3055@2|Bacteria,1QSB4@1224|Proteobacteria,1S2EP@1236|Gammaproteobacteria,1WZIK@135613|Chromatiales 135613|Chromatiales S Galactose oxidase, central domain - - - - - - - - - - - - Kelch_6 CMS1_k127_2613851_1 861299.J421_1359 3.158e-27 130.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS1_k127_2613851_2 221288.JH992901_gene3767 1.797e-24 119.0 COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria 1117|Cyanobacteria U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS1_k127_2700864_8 379066.GAU_0484 6.439e-15 76.0 COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV CMS1_k127_2700864_1 309800.C498_01035 1.221e-105 362.0 COG0520@1|root,arCOG00065@2157|Archaea,2XYKY@28890|Euryarchaeota,23ZYZ@183963|Halobacteria 183963|Halobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS1_k127_2700864_2 1463881.KL591008_gene2018 4.24e-72 249.0 COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria 201174|Actinobacteria K COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - - - - - - - - - - Hexapep CMS1_k127_2700864_4 1380391.JIAS01000014_gene2007 2.349e-22 104.0 COG1846@1|root,COG1846@2|Bacteria,1PD0X@1224|Proteobacteria,2VBMB@28211|Alphaproteobacteria,2JY08@204441|Rhodospirillales 204441|Rhodospirillales K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR_2 CMS1_k127_2700864_6 1550073.JROH01000011_gene2118 2.633e-18 92.0 COG4319@1|root,COG4319@2|Bacteria,1MZRB@1224|Proteobacteria,2UK7M@28211|Alphaproteobacteria,2K6RI@204457|Sphingomonadales 204457|Sphingomonadales S SnoaL-like domain - - - - - - - - - - - - DUF4440,SnoaL_3 CMS1_k127_2700864_5 1047013.AQSP01000097_gene1952 8.91e-19 101.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,TolB_like CMS1_k127_2700864_0 1047013.AQSP01000102_gene979 3.072e-158 537.0 COG0841@1|root,COG0841@2|Bacteria,2NQF8@2323|unclassified Bacteria 2|Bacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran CMS1_k127_2700864_9 1047013.AQSP01000142_gene124 1.036e-14 87.0 COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria 2|Bacteria O NHL repeat - - - - - - - - - - - - DUF5128,NHL,TolB_like CMS1_k127_2700864_7 1047013.AQSP01000142_gene124 1.89e-15 91.0 COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria 2|Bacteria O NHL repeat - - - - - - - - - - - - DUF5128,NHL,TolB_like CMS1_k127_2700864_3 1121930.AQXG01000001_gene1203 2.156e-71 250.0 COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran CMS1_k127_2708941_0 379066.GAU_2666 0.0 1291.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUMT@142182|Gemmatimonadetes 142182|Gemmatimonadetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_2708941_10 1265313.HRUBRA_01763 3.112e-18 91.0 COG1017@1|root,COG1017@2|Bacteria,1NA56@1224|Proteobacteria,1SDRC@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitric oxide dioxygenase activity VPA1107 - - - - - - - - - - - - CMS1_k127_2708941_3 861299.J421_1666 7.417e-96 345.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2708941_2 861299.J421_1664 1.063e-105 362.0 2E0UX@1|root,32WC9@2|Bacteria,1ZUE1@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2708941_7 1472716.KBK24_0110285 1.256e-35 138.0 2AY99@1|root,31QBJ@2|Bacteria,1RI92@1224|Proteobacteria,2VSPH@28216|Betaproteobacteria,1K7SH@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_2708941_4 1282360.ABAC460_22785 7.292e-58 218.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2U25R@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese CMS1_k127_2708941_5 1191523.MROS_1777 1.883e-49 182.0 COG2391@1|root,COG2391@2|Bacteria 2|Bacteria - - - - - ko:K07112 - - - - ko00000 - - - Sulf_transp CMS1_k127_2708941_6 1282360.ABAC460_22795 2.339e-49 194.0 COG2391@1|root,COG2391@2|Bacteria,1RIWE@1224|Proteobacteria,2U4F1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp CMS1_k127_2708941_12 1211114.ALIP01000119_gene436 2.481e-05 56.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1X4I1@135614|Xanthomonadales 135614|Xanthomonadales P Sulfurtransferase sseA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese CMS1_k127_2708941_1 518766.Rmar_1066 1.172e-162 529.0 COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,1FIX6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase CMS1_k127_2711125_0 1158318.ATXC01000001_gene182 5.295e-87 303.0 COG0543@1|root,COG0543@2|Bacteria,2G45B@200783|Aquificae 200783|Aquificae C Oxidoreductase NAD-binding domain - - - - - - - - - - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 CMS1_k127_2711125_1 374847.Kcr_0324 2.225e-86 297.0 COG1145@1|root,arCOG05128@2157|Archaea 2157|Archaea C 4 iron, 4 sulfur cluster binding hydB - 1.12.98.4 ko:K17996 ko00920,map00920 - R10390 - ko00000,ko00001,ko01000 - - - Fer4_22 CMS1_k127_2711125_2 1499967.BAYZ01000059_gene4769 9.452e-17 85.0 COG0745@1|root,COG0745@2|Bacteria,2NRCE@2323|unclassified Bacteria 2|Bacteria KT cheY-homologous receiver domain - - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg CMS1_k127_2711125_3 448385.sce0962 1.221e-05 48.0 COG0515@1|root,COG0642@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria 448385.sce0962|- T PhoQ Sensor - - - - - - - - - - - - - CMS1_k127_2713522_3 1379270.AUXF01000003_gene3871 4.044e-07 61.0 2A02A@1|root,30N4Q@2|Bacteria,1ZUUX@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2713522_2 1521187.JPIM01000018_gene450 1.436e-34 143.0 COG1651@1|root,COG1651@2|Bacteria,2G8TG@200795|Chloroflexi,375RW@32061|Chloroflexia 32061|Chloroflexia O PFAM DSBA oxidoreductase - - - - - - - - - - - - Thioredoxin_4 CMS1_k127_2713522_0 1379270.AUXF01000004_gene3163 7.059e-110 388.0 COG0457@1|root,COG0457@2|Bacteria 1379270.AUXF01000004_gene3163|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_2713522_1 1379270.AUXF01000004_gene3169 2.42e-41 164.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug,TonB_dep_Rec CMS1_k127_2715219_36 379066.GAU_1743 2.631e-17 85.0 COG0534@1|root,COG0534@2|Bacteria,1ZUAU@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MatE - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE CMS1_k127_2715219_34 867903.ThesuDRAFT_02230 1.036e-24 109.0 COG0500@1|root,COG1547@1|root,COG1547@2|Bacteria,COG2226@2|Bacteria,1V45D@1239|Firmicutes 1239|Firmicutes Q SAM-dependent methyltransferase ubiE7 - - - - - - - - - - - Methyltransf_25 CMS1_k127_2715219_35 926550.CLDAP_05910 5.9e-24 104.0 COG1522@1|root,COG1522@2|Bacteria,2G99D@200795|Chloroflexi 200795|Chloroflexi K PFAM regulatory protein AsnC Lrp family - - - - - - - - - - - - AsnC_trans_reg CMS1_k127_2715219_20 1254432.SCE1572_51570 4.726e-74 258.0 COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,42QW2@68525|delta/epsilon subdivisions,2WMRN@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos CMS1_k127_2715219_28 1379270.AUXF01000001_gene2417 2.889e-50 199.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS1_k127_2715219_24 1183438.GKIL_3198 1.237e-61 244.0 COG1879@1|root,COG1879@2|Bacteria,1G06J@1117|Cyanobacteria 1117|Cyanobacteria G PFAM periplasmic binding protein LacI transcriptional regulator - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 CMS1_k127_2715219_2 251221.35210640 9.371e-175 593.0 COG0383@1|root,COG0383@2|Bacteria,1G1RB@1117|Cyanobacteria 1117|Cyanobacteria G PFAM Glycosyl hydrolases family 38 C-terminal domain ams1 - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C CMS1_k127_2715219_22 1121346.KB899837_gene1284 6.741e-67 248.0 COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26R5U@186822|Paenibacillaceae 91061|Bacilli G Belongs to the binding-protein-dependent transport system permease family rbsC - - ko:K17214 ko02010,map02010 M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 CMS1_k127_2715219_6 570268.ANBB01000045_gene1201 2.586e-126 430.0 COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria 201174|Actinobacteria G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system rbsA - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran CMS1_k127_2715219_27 469383.Cwoe_5609 3.603e-55 209.0 COG0558@1|root,COG0558@2|Bacteria,2H9R3@201174|Actinobacteria 201174|Actinobacteria I CDP-alcohol phosphatidyltransferase - - - - - - - - - - - - CDP-OH_P_transf CMS1_k127_2715219_40 1000565.METUNv1_03628 6.536e-11 71.0 28TB7@1|root,2ZFJR@2|Bacteria,1PACM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_2715219_23 1120973.AQXL01000107_gene1971 9.299e-62 222.0 COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,4HA3H@91061|Bacilli 91061|Bacilli S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short CMS1_k127_2715219_32 926560.KE387023_gene1935 1.881e-39 154.0 COG1309@1|root,COG1309@2|Bacteria,1WMQG@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS1_k127_2715219_29 861299.J421_3999 1.824e-49 184.0 COG0400@1|root,COG0400@2|Bacteria,1ZTYG@142182|Gemmatimonadetes 142182|Gemmatimonadetes S carboxylic ester hydrolase activity - - - - - - - - - - - - - CMS1_k127_2715219_30 861299.J421_0057 4.03e-45 171.0 COG0782@1|root,COG0782@2|Bacteria,1ZTPD@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcription elongation factor, N-terminal - - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N CMS1_k127_2715219_12 1382356.JQMP01000004_gene54 9.03e-91 313.0 COG1622@1|root,COG1622@2|Bacteria,2G6C0@200795|Chloroflexi,27XKX@189775|Thermomicrobia 189775|Thermomicrobia C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C CMS1_k127_2715219_1 485913.Krac_7161 7.711e-202 646.0 COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi 200795|Chloroflexi C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 CMS1_k127_2715219_21 379066.GAU_0506 2.633e-72 249.0 COG1845@1|root,COG1845@2|Bacteria,1ZT8Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c oxidase subunit III - - 1.9.3.1 ko:K02276,ko:K02299 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.5,3.D.4.6 - - COX3 CMS1_k127_2715219_38 1379270.AUXF01000002_gene1828 4.72e-16 89.0 2EKS3@1|root,33EFV@2|Bacteria,1ZTY7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Prokaryotic Cytochrome C oxidase subunit IV - - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - COX4_pro CMS1_k127_2715219_7 861299.J421_3849 7.705e-115 391.0 COG0265@1|root,COG0265@2|Bacteria,1ZTG6@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS1_k127_2715219_0 861299.J421_3848 6.084e-312 967.0 COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 CMS1_k127_2715219_13 404589.Anae109_1579 1.432e-90 304.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2YVSU@29|Myxococcales 28221|Deltaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid CMS1_k127_2715219_37 648996.Theam_0313 3.76e-17 94.0 COG3203@1|root,COG3203@2|Bacteria,2G42A@200783|Aquificae 200783|Aquificae M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - CMS1_k127_2715219_26 379066.GAU_2370 1.293e-58 211.0 COG0704@1|root,COG0704@2|Bacteria 2|Bacteria P negative regulation of phosphate transmembrane transport phoU GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU CMS1_k127_2715219_10 1307759.JOMJ01000003_gene1214 1.243e-93 325.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2M7VZ@213115|Desulfovibrionales 28221|Deltaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran CMS1_k127_2715219_9 269799.Gmet_2704 2.142e-98 330.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,43U4R@69541|Desulfuromonadales 28221|Deltaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran CMS1_k127_2715219_19 1191523.MROS_2638 1.13e-76 280.0 COG0581@1|root,COG0581@2|Bacteria 2|Bacteria P inorganic phosphate transmembrane transporter activity pstA GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - ko:K02037,ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 CMS1_k127_2715219_15 768710.DesyoDRAFT_3277 6.155e-87 304.0 COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,26553@186807|Peptococcaceae 186801|Clostridia P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 CMS1_k127_2715219_8 644966.Tmar_1649 9.158e-110 367.0 COG0226@1|root,COG0226@2|Bacteria,1UFGH@1239|Firmicutes,24D85@186801|Clostridia,3WDS1@538999|Clostridiales incertae sedis 186801|Clostridia P TIGRFAM phosphate ABC transporter, phosphate-binding protein - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 CMS1_k127_2715219_33 861299.J421_1892 4.684e-26 123.0 2ES4T@1|root,33JPM@2|Bacteria,1ZU4W@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2715219_14 379066.GAU_2360 2.233e-90 324.0 COG5002@1|root,COG5002@2|Bacteria,1ZT2H@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA CMS1_k127_2715219_11 1379270.AUXF01000003_gene3568 2.778e-93 314.0 COG0745@1|root,COG0745@2|Bacteria,1ZTC6@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C CMS1_k127_2715219_31 861299.J421_3846 2.296e-44 171.0 COG1392@1|root,COG1392@2|Bacteria,1ZTKX@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div CMS1_k127_2715219_5 379066.GAU_2373 2.039e-127 419.0 COG0306@1|root,COG0306@2|Bacteria,1ZSZ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Phosphate transporter family - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 CMS1_k127_2715219_3 1379270.AUXF01000003_gene3570 9.507e-133 470.0 COG0737@1|root,COG0737@2|Bacteria,1ZTEA@142182|Gemmatimonadetes 142182|Gemmatimonadetes F 5'-nucleotidase, C-terminal domain - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos CMS1_k127_2715219_17 518766.Rmar_2501 1.003e-80 289.0 COG1816@1|root,COG1816@2|Bacteria,4NJ8S@976|Bacteroidetes,1FJ2C@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Adenosine/AMP deaminase - - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase CMS1_k127_2715219_4 935863.AWZR01000007_gene223 2.33e-129 442.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,1X3AE@135614|Xanthomonadales 135614|Xanthomonadales F Na dependent nucleoside transporter yeiM - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N CMS1_k127_2715219_16 1379270.AUXF01000003_gene3573 1.99e-83 285.0 COG0005@1|root,COG0005@2|Bacteria,1ZTGZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate - - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 CMS1_k127_2715219_25 861299.J421_0308 8.45e-60 219.0 COG1595@1|root,COG1595@2|Bacteria,1ZTP3@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2715219_18 861299.J421_0306 1.27e-78 281.0 COG1413@1|root,COG1413@2|Bacteria,1ZTQY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS1_k127_272207_26 1121406.JAEX01000002_gene972 1.742e-43 162.0 COG0599@1|root,COG0599@2|Bacteria,1N38Z@1224|Proteobacteria,42WA7@68525|delta/epsilon subdivisions,2WRWX@28221|Deltaproteobacteria,2MCC2@213115|Desulfovibrionales 28221|Deltaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD CMS1_k127_272207_9 1379270.AUXF01000002_gene1577 7.058e-145 484.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_272207_40 335543.Sfum_2036 9.546e-13 82.0 28VPN@1|root,2ZHRK@2|Bacteria,1P914@1224|Proteobacteria,432EX@68525|delta/epsilon subdivisions,2WXPK@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_272207_18 323848.Nmul_A0638 1.531e-73 273.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2WGWX@28216|Betaproteobacteria,37279@32003|Nitrosomonadales 28216|Betaproteobacteria T Cache domain - - - - - - - - - - - - GGDEF,HAMP,dCache_1 CMS1_k127_272207_43 1094561.MEI_00592 2.192e-05 55.0 COG3807@1|root,COG3807@2|Bacteria,1RHM2@1224|Proteobacteria,2UA1R@28211|Alphaproteobacteria,48T66@772|Bartonellaceae 28211|Alphaproteobacteria S Bacterial SH3 domain homologues MA20_24010 - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - SH3_4 CMS1_k127_272207_24 861299.J421_3204 1.397e-45 175.0 COG0127@1|root,COG0127@2|Bacteria,1ZTSC@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Ham1 family - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like CMS1_k127_272207_15 861299.J421_3203 7.122e-78 271.0 COG0689@1|root,COG0689@2|Bacteria,1ZSYT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C CMS1_k127_272207_27 880072.Desac_2006 1.872e-42 162.0 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria,2MQJ3@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose rfaE - - - - - - - - - - - CTP_transf_like CMS1_k127_272207_7 530564.Psta_1035 1.125e-163 533.0 COG1055@1|root,COG1055@2|Bacteria,2IY4X@203682|Planctomycetes 203682|Planctomycetes P COG1055 Na H antiporter NhaD and related arsenite - - - - - - - - - - - - CitMHS_2 CMS1_k127_272207_32 861299.J421_3201 1.662e-35 150.0 2EPTK@1|root,33HE4@2|Bacteria,1ZTUK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lipopolysaccharide-assembly - - - - - - - - - - - - LptE CMS1_k127_272207_45 379066.GAU_1568 0.0001466 52.0 2F5A9@1|root,33XWF@2|Bacteria,1ZTU9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_272207_4 880073.Calab_2849 6.663e-177 588.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NQSG@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - BSP,Bac_surface_Ag,PD40,Peptidase_MA_2 CMS1_k127_272207_23 1089550.ATTH01000001_gene840 3.957e-50 201.0 COG0652@1|root,COG1413@1|root,COG0652@2|Bacteria,COG1413@2|Bacteria,4PF1U@976|Bacteroidetes,1FK0E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes CO Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - HEAT_2,Pro_isomerase CMS1_k127_272207_33 861299.J421_3199 4.94e-28 121.0 COG0824@1|root,COG0824@2|Bacteria,1ZTY3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT CMS1_k127_272207_30 861299.J421_3198 4.125e-41 161.0 COG2908@1|root,COG2908@2|Bacteria,1ZTNP@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Calcineurin-like phosphoesterase - - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos CMS1_k127_272207_41 379066.GAU_1564 6.142e-10 71.0 2FIMZ@1|root,34ADU@2|Bacteria,1ZTYV@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_272207_28 880073.Calab_0150 2.215e-42 168.0 COG1597@1|root,COG1597@2|Bacteria,2NQYH@2323|unclassified Bacteria 2|Bacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat CMS1_k127_272207_29 709032.Sulku_0742 2.98e-41 155.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2YPGD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP CMS1_k127_272207_2 1217720.ALOX01000057_gene1072 1.077e-207 663.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,2JQ9A@204441|Rhodospirillales 204441|Rhodospirillales F formate-tetrahydrofolate ligase activity fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS CMS1_k127_272207_22 1379270.AUXF01000005_gene828 1.124e-55 216.0 COG0084@1|root,COG0084@2|Bacteria,1ZST0@142182|Gemmatimonadetes 142182|Gemmatimonadetes L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase CMS1_k127_272207_17 379066.GAU_1561 1.033e-74 271.0 COG0341@1|root,COG0341@2|Bacteria,1ZSSV@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS1_k127_272207_10 1379698.RBG1_1C00001G0345 7.819e-119 401.0 COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS1_k127_272207_14 1379270.AUXF01000005_gene825 3.416e-88 316.0 COG0196@1|root,COG0196@2|Bacteria,1ZSM5@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Riboflavin kinase - - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase CMS1_k127_272207_21 471852.Tcur_3327 1.734e-60 224.0 COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4EGVA@85012|Streptosporangiales 201174|Actinobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C,TruB_C_2,TruB_N CMS1_k127_272207_37 760568.Desku_2542 1.617e-23 104.0 COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,262H0@186807|Peptococcaceae 186801|Clostridia J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA CMS1_k127_272207_39 765420.OSCT_2975 8.009e-14 76.0 COG1550@1|root,COG1550@2|Bacteria,2G765@200795|Chloroflexi,375YB@32061|Chloroflexia 32061|Chloroflexia S Protein of unknown function (DUF503) - - - ko:K09764 - - - - ko00000 - - - DUF503 CMS1_k127_272207_1 518766.Rmar_1309 3.328e-210 685.0 COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,1FIVX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N CMS1_k127_272207_44 891391.LAC30SC_07030 3.021e-05 57.0 COG1358@1|root,COG1358@2|Bacteria,1VEYG@1239|Firmicutes,4HNY7@91061|Bacilli,3F7ZK@33958|Lactobacillaceae 91061|Bacilli J ribosomal protein ylxQ - - - - - - - - - - - Ribosomal_L7Ae CMS1_k127_272207_3 379066.GAU_1554 5.059e-194 620.0 COG0195@1|root,COG0195@2|Bacteria,1ZSNN@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N CMS1_k127_272207_35 379066.GAU_1553 7.481e-26 113.0 COG0779@1|root,COG0779@2|Bacteria,1ZTX3@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C CMS1_k127_272207_25 379066.GAU_1552 1.997e-45 181.0 COG1496@1|root,COG1496@2|Bacteria,1ZTTT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Multi-copper polyphenol oxidoreductase laccase - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 CMS1_k127_272207_6 861299.J421_3183 3.717e-164 545.0 COG0766@1|root,COG0766@2|Bacteria,1ZSZ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase CMS1_k127_272207_12 861299.J421_3181 1.448e-106 354.0 28Q1P@1|root,2ZB8E@2|Bacteria,1ZSPA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Zinc dependent phospholipase C - - - - - - - - - - - - Zn_dep_PLPC CMS1_k127_272207_0 1379270.AUXF01000005_gene811 1.309e-218 718.0 COG0210@1|root,COG0210@2|Bacteria,1ZTD5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C CMS1_k127_272207_16 379066.GAU_1544 9.26e-78 274.0 COG5000@1|root,COG5000@2|Bacteria,1ZSKZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c CMS1_k127_272207_8 861299.J421_3175 3.646e-148 480.0 COG0172@1|root,COG0172@2|Bacteria,1ZT0V@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b CMS1_k127_272207_38 861299.J421_3174 4.304e-17 88.0 2FES0@1|root,346R1@2|Bacteria,1ZU3X@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_272207_36 1379270.AUXF01000005_gene807 2.543e-24 107.0 COG2018@1|root,COG2018@2|Bacteria,1ZU1J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Roadblock/LC7 domain - - - ko:K07131 - - - - ko00000 - - - Robl_LC7 CMS1_k127_272207_13 861299.J421_3171 3.727e-98 331.0 COG0836@1|root,COG0836@2|Bacteria,1ZT5Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Nucleotidyl transferase - - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase CMS1_k127_272207_19 861299.J421_3170 4.627e-70 252.0 COG1208@1|root,COG1208@2|Bacteria,1ZSVN@142182|Gemmatimonadetes 142182|Gemmatimonadetes JM Sugar nucleotidyl transferase - - - - - - - - - - - - NTP_transf_4 CMS1_k127_272207_31 644282.Deba_0900 9.369e-39 166.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,42NE6@68525|delta/epsilon subdivisions,2WJ92@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B,Lactamase_B_2 CMS1_k127_272207_20 1379270.AUXF01000001_gene2066 1.003e-67 259.0 COG2206@1|root,COG2206@2|Bacteria 2|Bacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD CMS1_k127_272207_34 269799.Gmet_2816 1.048e-27 130.0 COG1413@1|root,COG1413@2|Bacteria,1N5TU@1224|Proteobacteria,42UDF@68525|delta/epsilon subdivisions,2WQ3K@28221|Deltaproteobacteria,43TQ4@69541|Desulfuromonadales 28221|Deltaproteobacteria C lyase activity - - - - - - - - - - - - HEAT_2 CMS1_k127_272207_11 1278073.MYSTI_02808 1.061e-106 359.0 COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria 1224|Proteobacteria S major pilin protein fima MA20_16755 - - - - - - - - - - - DUF1028 CMS1_k127_272207_5 379066.GAU_1536 1.176e-172 546.0 COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS1_k127_2727271_4 1049564.TevJSym_aq00680 1.978e-69 243.0 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1JBVX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfE2 - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr CMS1_k127_2727271_3 1049564.TevJSym_aq00670 6.863e-75 257.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1J4WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr CMS1_k127_2727271_5 1232410.KI421412_gene63 5.668e-47 182.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,43S4W@69541|Desulfuromonadales 28221|Deltaproteobacteria M Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE CMS1_k127_2727271_6 1110502.TMO_3523 1.446e-38 155.0 COG1028@1|root,COG1028@2|Bacteria,1N8G3@1224|Proteobacteria,2TUTY@28211|Alphaproteobacteria,2JXEK@204441|Rhodospirillales 204441|Rhodospirillales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - - CMS1_k127_2727271_2 661478.OP10G_2024 3.618e-80 289.0 2CEN7@1|root,2Z9XA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_2727271_9 504472.Slin_0949 4.197e-25 110.0 COG1695@1|root,COG1695@2|Bacteria,4NQ31@976|Bacteroidetes,47UWR@768503|Cytophagia 976|Bacteroidetes K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS1_k127_2727271_0 1047013.AQSP01000138_gene1017 0.0 1139.0 COG0612@1|root,COG0612@2|Bacteria,2NP5H@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_2727271_8 1169161.KB897737_gene2445 1.131e-34 139.0 COG0242@1|root,COG0242@2|Bacteria 2|Bacteria J peptide deformylase activity - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - HTH_31,Pep_deformylase CMS1_k127_2727271_7 316067.Geob_0102 1.042e-37 149.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,42SCH@68525|delta/epsilon subdivisions,2WPMA@28221|Deltaproteobacteria,43SR2@69541|Desulfuromonadales 28221|Deltaproteobacteria S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 CMS1_k127_2727271_1 1158345.JNLL01000001_gene544 4.079e-195 617.0 COG0422@1|root,COG0422@2|Bacteria,2G3RS@200783|Aquificae 200783|Aquificae H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM CMS1_k127_2735634_0 402777.KB235903_gene1837 7.679e-66 228.0 COG0467@1|root,COG0467@2|Bacteria,1G2R3@1117|Cyanobacteria,1HA0C@1150|Oscillatoriales 1117|Cyanobacteria T in signal transduction - - - ko:K08482 - - - - ko00000 - - - ATPase CMS1_k127_2735634_2 861299.J421_3550 1.691e-28 123.0 COG2885@1|root,COG2885@2|Bacteria,1ZTSM@142182|Gemmatimonadetes 142182|Gemmatimonadetes M OmpA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA CMS1_k127_2735634_1 861299.J421_6150 6.673e-35 136.0 2DF6S@1|root,2ZQP7@2|Bacteria,1ZU7F@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2743149_24 861299.J421_0442 2.529e-18 88.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2743149_18 643562.Daes_2111 3.545e-47 183.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria,2M9YK@213115|Desulfovibrionales 28221|Deltaproteobacteria O XdhC and CoxI family - - - ko:K07402 - - - - ko00000 - - - NTP_transf_3,XdhC_C,XdhC_CoxI CMS1_k127_2743149_19 391009.Tmel_1918 1.97e-45 166.0 COG0599@1|root,COG0599@2|Bacteria,2GD25@200918|Thermotogae 200918|Thermotogae S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD CMS1_k127_2743149_14 1121405.dsmv_1663 2.276e-57 218.0 COG5557@1|root,COG5557@2|Bacteria,1QURB@1224|Proteobacteria,43BT1@68525|delta/epsilon subdivisions,2X73S@28221|Deltaproteobacteria,2MMX3@213118|Desulfobacterales 28221|Deltaproteobacteria C Pfam Polysulphide reductase, NrfD actF - - - - - - - - - - - - CMS1_k127_2743149_22 246197.MXAN_5554 1.257e-21 104.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c actE - - - - - - - - - - - Cytochrome_CBB3 CMS1_k127_2743149_21 1379270.AUXF01000003_gene3824 5.71e-29 134.0 COG2010@1|root,COG2010@2|Bacteria,1ZTMS@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF3341) - - - - - - - - - - - - DUF3341 CMS1_k127_2743149_2 379066.GAU_2035 1.387e-180 578.0 COG5557@1|root,COG5557@2|Bacteria,1ZSN2@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD CMS1_k127_2743149_0 861299.J421_3630 1.632e-239 774.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal CMS1_k127_2743149_20 1313301.AUGC01000004_gene2248 3.569e-39 153.0 COG2010@1|root,COG2010@2|Bacteria,4NF0A@976|Bacteroidetes 976|Bacteroidetes C cytochrome C actA - - - - - - - - - - - Cytochrom_C,Cytochrom_CIII,Cytochrome_C7 CMS1_k127_2743149_16 861299.J421_3632 8.423e-54 212.0 COG2159@1|root,COG2159@2|Bacteria,1ZTHS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S amidohydrolase - - - - - - - - - - - - - CMS1_k127_2743149_7 861299.J421_3633 1.191e-110 364.0 COG2159@1|root,COG2159@2|Bacteria,1ZSXA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 CMS1_k127_2743149_9 379066.GAU_2040 1.991e-80 282.0 COG0001@1|root,COG0001@2|Bacteria,1ZSWU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_2743149_15 1499967.BAYZ01000100_gene3464 7.822e-57 208.0 COG0565@1|root,COG0565@2|Bacteria,2NQ39@2323|unclassified Bacteria 2|Bacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 ko:K01883,ko:K02533,ko:K08281,ko:K15396 ko00760,ko00970,ko01100,map00760,map00970,map01100 M00359,M00360 R01268,R03650 RC00055,RC00100,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - SpoU_methylase CMS1_k127_2743149_6 861299.J421_3636 4.271e-129 447.0 2AEF2@1|root,314A1@2|Bacteria,1ZSNZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Heparinase II/III-like protein - - - - - - - - - - - - Hepar_II_III CMS1_k127_2743149_13 1128421.JAGA01000002_gene806 6.098e-60 226.0 COG2605@1|root,COG2605@2|Bacteria 1128421.JAGA01000002_gene806|- G GHMP kinase - - - - - - - - - - - - - CMS1_k127_2743149_5 861299.J421_3637 3.392e-138 459.0 COG0747@1|root,COG0747@2|Bacteria,1ZTAS@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 CMS1_k127_2743149_10 861299.J421_3638 7.222e-79 276.0 COG0601@1|root,COG0601@2|Bacteria,1ZT46@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS1_k127_2743149_12 861299.J421_3639 7.853e-65 244.0 COG1173@1|root,COG1173@2|Bacteria,1ZTI1@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS1_k127_2743149_17 1298880.AUEV01000002_gene1402 3.16e-50 201.0 COG2303@1|root,COG2303@2|Bacteria,2GNHC@201174|Actinobacteria 201174|Actinobacteria E glucose-methanol-choline oxidoreductase - - 1.1.1.400 ko:K20927,ko:K21166 ko01059,ko01130,map01059,map01130 M00824 - - ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N CMS1_k127_2743149_3 861299.J421_3641 2.402e-157 528.0 COG0383@1|root,COG0383@2|Bacteria,1ZT4Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Alpha mannosidase, middle domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38 CMS1_k127_2743149_26 1028801.RG1141_PA09930 1.334e-11 78.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4BA3T@82115|Rhizobiaceae 28211|Alphaproteobacteria O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS1_k127_2743149_25 1157640.AQWO01000005_gene2183 1.708e-14 87.0 COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,2GKEU@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K01990,ko:K21397 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC_tran,FHA,Yop-YscD_cpl CMS1_k127_2743149_11 379066.GAU_1151 2.352e-75 281.0 COG0515@1|root,COG0515@2|Bacteria,1ZTB4@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2743149_8 880073.Calab_1414 2.701e-88 322.0 COG0388@1|root,COG0388@2|Bacteria,2NPKU@2323|unclassified Bacteria 2|Bacteria S Carbon-nitrogen hydrolase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase CMS1_k127_2743149_4 36809.MAB_3646c 4.961e-140 457.0 COG0160@1|root,COG0160@2|Bacteria,2GJNQ@201174|Actinobacteria,233JV@1762|Mycobacteriaceae 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lat - 2.6.1.36 ko:K03918 ko01100,map01100 - R00457 RC00006,RC00062 ko00000,ko01000,ko01007 - - iNJ661.Rv3290c Aminotran_3 CMS1_k127_2743149_1 1121104.AQXH01000001_gene2028 1.435e-196 634.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IQYT@117747|Sphingobacteriia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran CMS1_k127_2743184_0 251229.Chro_4813 1.767e-255 809.0 COG1749@1|root,COG1749@2|Bacteria,1GBDW@1117|Cyanobacteria 1117|Cyanobacteria N Domain of unknown function (DUF4082) - - - - - - - - - - - - Big_5,DUF4082 CMS1_k127_2753407_6 365046.Rta_04620 4.465e-141 463.0 COG0715@1|root,COG0715@2|Bacteria,1RJQU@1224|Proteobacteria,2VVYG@28216|Betaproteobacteria 28216|Betaproteobacteria P Protein of unknown function (DUF3500) - - - - - - - - - - - - DUF3500 CMS1_k127_2753407_16 448385.sce0363 9.122e-116 392.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS1_k127_2753407_30 215803.DB30_3805 5.181e-59 229.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2YXUC@29|Myxococcales 28221|Deltaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS1_k127_2753407_14 379066.GAU_3348 1.837e-121 413.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2753407_0 861299.J421_3107 3.56e-189 618.0 COG1884@1|root,COG1884@2|Bacteria,1ZT5I@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase CMS1_k127_2753407_15 861299.J421_3106 9.509e-120 393.0 COG0158@1|root,COG0158@2|Bacteria,1ZTAZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Fructose-1-6-bisphosphatase, N-terminal domain fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase CMS1_k127_2753407_24 1379270.AUXF01000005_gene709 5.413e-83 303.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1ZSMY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Competence protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,Lactamase_B CMS1_k127_2753407_40 1125701.HMPREF1221_00025 3.128e-09 70.0 2BRMP@1|root,32KM3@2|Bacteria,2J6W4@203691|Spirochaetes 203691|Spirochaetes S PFAM Late competence development protein ComFB - - - ko:K02241 - M00429 - - ko00000,ko00002,ko02044 - - - ComFB CMS1_k127_2753407_3 861299.J421_3101 3.743e-176 582.0 COG0621@1|root,COG0621@2|Bacteria,1ZT0Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 CMS1_k127_2753407_28 269799.Gmet_0874 7.849e-64 246.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2WJ1H@28221|Deltaproteobacteria,43TX0@69541|Desulfuromonadales 28221|Deltaproteobacteria J SMART Elongator protein 3 MiaB NifB mtaB - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 CMS1_k127_2753407_36 861299.J421_3097 3.72e-25 123.0 2EYUI@1|root,33S1Q@2|Bacteria,1ZTHR@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2753407_39 379066.GAU_1452 2.514e-20 106.0 2F0K0@1|root,33TNP@2|Bacteria,1ZTJU@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2753407_34 379066.GAU_1451 1.242e-31 132.0 COG0295@1|root,COG0295@2|Bacteria,1ZTZY@142182|Gemmatimonadetes 142182|Gemmatimonadetes F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis - - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 CMS1_k127_2753407_7 861299.J421_3094 6.786e-141 466.0 COG1015@1|root,COG1015@2|Bacteria,1ZTG3@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme CMS1_k127_2753407_25 861299.J421_3093 6.434e-83 288.0 COG0787@1|root,COG0787@2|Bacteria,1ZT57@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids - - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N CMS1_k127_2753407_26 861299.J421_3092 1.048e-69 246.0 COG1694@1|root,COG3956@2|Bacteria,1ZSZH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S MazG nucleotide pyrophosphohydrolase domain - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - MazG CMS1_k127_2753407_1 379066.GAU_1447 2.634e-181 576.0 COG0017@1|root,COG0017@2|Bacteria,1ZSTX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class II (D, K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon CMS1_k127_2753407_43 1214242.B446_20935 0.000467 53.0 COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2GIV0@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase - - - - - - - - - - - - PQQ_2,PQQ_3,Pkinase CMS1_k127_2753407_33 330214.NIDE0156 9.611e-32 136.0 COG2154@1|root,COG2154@2|Bacteria 2|Bacteria H pterin-4-alpha-carbinolamine dehydratase phhB GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a CMS1_k127_2753407_5 575540.Isop_2571 6.427e-161 513.0 COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes 203682|Planctomycetes P COG0798 Arsenite efflux pump ACR3 and related - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF CMS1_k127_2753407_18 42256.RradSPS_3006 3.674e-102 338.0 COG0639@1|root,COG0639@2|Bacteria 2|Bacteria T phosphoprotein phosphatase activity - - - - - - - - - - - - Metallophos_2 CMS1_k127_2753407_17 1122962.AULH01000045_gene3920 8.871e-109 366.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2TR8A@28211|Alphaproteobacteria,3719Y@31993|Methylocystaceae 28211|Alphaproteobacteria Q ubiE/COQ5 methyltransferase family - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_11,Methyltransf_31 CMS1_k127_2753407_38 258052.JNYV01000002_gene1048 2.384e-22 100.0 COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,2M3IT@2063|Kitasatospora 201174|Actinobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 CMS1_k127_2753407_32 886293.Sinac_6279 1.387e-42 159.0 COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes 203682|Planctomycetes K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R CMS1_k127_2753407_22 861299.J421_1461 2.52e-86 316.0 COG4219@1|root,COG4219@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CarboxypepD_reg,HEAT_2,Peptidase_M56,Secretin,TonB_C CMS1_k127_2753407_41 395019.Bmul_4759 8.889e-09 69.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity MA20_20600 - 1.14.17.3 ko:K00504 - - - - ko00000,ko01000 - - - Endonuclease_NS,NHL CMS1_k127_2753407_4 1379698.RBG1_1C00001G0402 6.081e-166 547.0 COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria 2|Bacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge CMS1_k127_2753407_23 379066.GAU_1442 2.738e-85 304.0 COG0552@1|root,COG0552@2|Bacteria,1ZTBT@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N CMS1_k127_2753407_31 861299.J421_3082 3.326e-49 197.0 COG1572@1|root,COG1572@2|Bacteria,1ZSTW@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - - CMS1_k127_2753407_35 1300345.LF41_497 7.921e-29 126.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1X3ZJ@135614|Xanthomonadales 135614|Xanthomonadales E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth CMS1_k127_2753407_29 1323663.AROI01000013_gene273 4.003e-59 231.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 CMS1_k127_2753407_2 861299.J421_3080 3.284e-179 571.0 COG0206@1|root,COG0206@2|Bacteria,1ZSNH@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin CMS1_k127_2753407_9 861299.J421_3079 1.269e-131 435.0 COG0849@1|root,COG0849@2|Bacteria,1ZSRE@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA CMS1_k127_2753407_37 861299.J421_3078 8.316e-23 107.0 COG1589@1|root,COG1589@2|Bacteria,1ZTRX@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell division protein FtsQ - - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - POTRA_1 CMS1_k127_2753407_11 861299.J421_3077 2.046e-124 413.0 COG0773@1|root,COG0773@2|Bacteria,1ZSQG@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M CMS1_k127_2753407_21 861299.J421_3076 9.996e-87 315.0 COG0707@1|root,COG0707@2|Bacteria,1ZSW5@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 CMS1_k127_2753407_27 330214.NIDE0760 1.193e-68 255.0 COG0772@1|root,COG0772@2|Bacteria,3J0M8@40117|Nitrospirae 40117|Nitrospirae D Cell cycle protein ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE CMS1_k127_2753407_12 861299.J421_3074 4.79e-122 423.0 COG0771@1|root,COG0771@2|Bacteria,1ZT38@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M CMS1_k127_2753407_10 861299.J421_3073 5.867e-127 437.0 COG0472@1|root,COG0472@2|Bacteria,1ZT4Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4 CMS1_k127_2753407_20 1379270.AUXF01000005_gene686 1.038e-88 325.0 COG0770@1|root,COG0770@2|Bacteria,1ZT1U@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M CMS1_k127_2753407_8 861299.J421_3071 1.859e-137 478.0 COG0769@1|root,COG0769@2|Bacteria,1ZSS3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M CMS1_k127_2753407_13 861299.J421_3070 7.675e-122 414.0 COG0768@1|root,COG0768@2|Bacteria,1ZSYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Penicillin binding protein transpeptidase domain - - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase CMS1_k127_2753407_19 861299.J421_3068 1.022e-90 310.0 COG0275@1|root,COG0275@2|Bacteria,1ZT4V@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 CMS1_k127_2757826_4 192952.MM_0870 2.785e-40 151.0 COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia 224756|Methanomicrobia I PFAM Thiolase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAF692.Mbar_A0550 Thiolase_C,Thiolase_N CMS1_k127_2757826_5 694431.DESACE_06835 2.379e-31 130.0 COG1545@1|root,COG1545@2|Bacteria 2|Bacteria I DUF35 OB-fold domain, acyl-CoA-associated phlB - - ko:K07068,ko:K07549 ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220 M00418 R05587 RC00004,RC01428,RC02904 ko00000,ko00001,ko00002,ko01000 - - - DUF35_N,OB_aCoA_assoc CMS1_k127_2757826_0 1047013.AQSP01000126_gene2740 0.0 1088.0 COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria 2|Bacteria E Zinc carboxypeptidase - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS1_k127_2757826_1 1121033.AUCF01000003_gene3513 8.364e-129 418.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,2TS53@28211|Alphaproteobacteria,2JYWX@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the peptidase S33 family - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 CMS1_k127_2757826_2 1453501.JELR01000002_gene920 1.03e-70 257.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,467AP@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane protein, hemolysin III homolog yqfA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII CMS1_k127_2757826_3 861299.J421_6033 8.487e-69 246.0 COG3324@1|root,COG3324@2|Bacteria,1ZU3H@142182|Gemmatimonadetes 142182|Gemmatimonadetes E translation initiation factor activity - - - ko:K06996 - - - - ko00000 - - - Glyoxalase CMS1_k127_2757826_7 861299.J421_5875 5.03e-19 89.0 2F75B@1|root,33ZKU@2|Bacteria,1ZTZQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_2757826_8 1392491.JIAE01000001_gene1524 2.355e-14 84.0 COG2931@1|root,COG4676@1|root,COG2931@2|Bacteria,COG4676@2|Bacteria 2|Bacteria UW Protein conserved in bacteria - - - - - - - - - - - - VCBS CMS1_k127_2757826_9 1047013.AQSP01000131_gene1844 4.336e-10 70.0 COG1238@1|root,COG1238@2|Bacteria 2|Bacteria I metal cluster binding yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - SNARE_assoc CMS1_k127_2757826_6 861299.J421_0728 1.052e-22 101.0 COG3315@1|root,COG3315@2|Bacteria 2|Bacteria Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - - - - - - - - - - LCM CMS1_k127_2781967_3 861299.J421_3607 1.057e-167 545.0 COG0363@1|root,COG2120@1|root,COG0363@2|Bacteria,COG2120@2|Bacteria,1ZSQV@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase - - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso,PIG-L CMS1_k127_2781967_2 382464.ABSI01000020_gene126 9.942e-205 650.0 COG3534@1|root,COG3534@2|Bacteria 2|Bacteria G alpha-L-arabinofuranosidase asdII - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C CMS1_k127_2781967_8 1380394.JADL01000001_gene3088 1.73e-103 350.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,2JQ6K@204441|Rhodospirillales 204441|Rhodospirillales O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA CMS1_k127_2781967_0 1089550.ATTH01000001_gene2097 4.274e-288 919.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PHV0@976|Bacteroidetes,1FJM6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,SnoaL_2 CMS1_k127_2781967_10 509190.Cseg_0864 3.126e-21 99.0 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2UDEK@28211|Alphaproteobacteria,2KGZA@204458|Caulobacterales 204458|Caulobacterales S PFAM Membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 CMS1_k127_2781967_1 1047013.AQSP01000121_gene2697 2.119e-232 759.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_2781967_4 243231.GSU1204 2.701e-136 465.0 COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,43T1F@69541|Desulfuromonadales 28221|Deltaproteobacteria P Sodium/hydrogen exchanger family - - - ko:K03455,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.2 - - Na_H_Exchanger,TrkA_C,TrkA_N CMS1_k127_2781967_7 326427.Cagg_1601 1.013e-111 368.0 COG0123@1|root,COG0123@2|Bacteria,2G89I@200795|Chloroflexi,376ST@32061|Chloroflexia 32061|Chloroflexia BQ PFAM histone deacetylase superfamily - - - - - - - - - - - - Hist_deacetyl CMS1_k127_2781967_5 379066.GAU_1124 6.808e-118 392.0 COG0484@1|root,COG0484@2|Bacteria,1ZT5T@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG CMS1_k127_2781967_9 861299.J421_2889 3.793e-37 148.0 COG0576@1|root,COG0576@2|Bacteria,1ZTSJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE CMS1_k127_2781967_6 861299.J421_2888 3.346e-114 383.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1ZSS9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Competence-damaged protein - - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth CMS1_k127_2794013_5 1384054.N790_04135 1.869e-74 260.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1X37F@135614|Xanthomonadales 135614|Xanthomonadales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF CMS1_k127_2794013_0 1047013.AQSP01000059_gene2095 3.375e-149 488.0 COG1757@1|root,COG1757@2|Bacteria,2NRD3@2323|unclassified Bacteria 2|Bacteria C Na+/H+ antiporter family nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter CMS1_k127_2794013_3 251221.35214984 3.253e-108 359.0 COG0861@1|root,COG0861@2|Bacteria 2|Bacteria P Integral membrane protein TerC family alx GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K05794 - - - - ko00000 - - - TerC CMS1_k127_2794013_1 861299.J421_4481 1.106e-114 378.0 COG0501@1|root,COG0501@2|Bacteria,1ZSNK@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 CMS1_k127_2794013_4 1206731.BAGB01000041_gene8378 1.573e-100 345.0 COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4FWXS@85025|Nocardiaceae 201174|Actinobacteria C Aldehyde dehydrogenase family - - 1.2.99.10 ko:K22445 - - - - ko00000,ko01000 - - - Aldedh CMS1_k127_2794013_6 1121405.dsmv_3775 8.789e-69 247.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42S8R@68525|delta/epsilon subdivisions,2X5W1@28221|Deltaproteobacteria,2MK5S@213118|Desulfobacterales 28221|Deltaproteobacteria C [2Fe-2S] binding domain - - 1.3.99.16 ko:K07302,ko:K13483 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Fer2_2 CMS1_k127_2794013_2 335543.Sfum_2511 8.388e-110 362.0 COG1319@1|root,COG1319@2|Bacteria,1MVJS@1224|Proteobacteria,42RX4@68525|delta/epsilon subdivisions,2WNBJ@28221|Deltaproteobacteria,2MQZF@213462|Syntrophobacterales 28221|Deltaproteobacteria C CO dehydrogenase flavoprotein C-terminal domain - - 1.17.1.4 ko:K11178 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5 CMS1_k127_2804474_0 1244869.H261_06576 9.162e-134 441.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales 204441|Rhodospirillales C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM CMS1_k127_2804474_1 344747.PM8797T_25016 2.22e-23 107.0 2E2CP@1|root,32XHN@2|Bacteria,2J0IA@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS1_k127_2804474_2 1379270.AUXF01000007_gene872 1.305e-12 70.0 COG0513@1|root,COG0513@2|Bacteria,1ZT7G@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DEAD-like helicases superfamily - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C CMS1_k127_2808537_7 479434.Sthe_2045 3.752e-06 49.0 COG0389@1|root,COG0389@2|Bacteria 2|Bacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII imuB - 2.7.7.7 ko:K02346,ko:K14161 - - - - ko00000,ko01000,ko03400 - - - IMS CMS1_k127_2808537_6 479434.Sthe_2046 1.308e-07 59.0 29U2R@1|root,30FC1@2|Bacteria,2G9M3@200795|Chloroflexi 200795|Chloroflexi - - - - - - - - - - - - - - - CMS1_k127_2808537_0 204669.Acid345_4047 5.134e-189 632.0 COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria,2JKQG@204432|Acidobacteriia 204432|Acidobacteriia L Belongs to the DNA polymerase type-C family. DnaE2 subfamily - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon CMS1_k127_2808537_2 313596.RB2501_05340 2.495e-35 139.0 COG0251@1|root,COG0251@2|Bacteria,4NPF9@976|Bacteroidetes,1I1J9@117743|Flavobacteriia 976|Bacteroidetes J endoribonuclease L-PSP - - - - - - - - - - - - YjgF_endoribonc CMS1_k127_2808537_5 414684.RC1_2804 7.586e-21 103.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,2JQBK@204441|Rhodospirillales 204441|Rhodospirillales C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_2808537_1 1192034.CAP_4478 4.886e-38 156.0 COG0491@1|root,COG0491@2|Bacteria,1NGQE@1224|Proteobacteria 1224|Proteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B CMS1_k127_2808537_3 1245469.S58_17590 6.09e-34 133.0 COG0640@1|root,COG0640@2|Bacteria,1N8QA@1224|Proteobacteria,2UC02@28211|Alphaproteobacteria,3JZ6B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor ybzH - - - - - - - - - - - HTH_20 CMS1_k127_2808537_4 234267.Acid_6108 1.476e-33 138.0 COG4798@1|root,COG4798@2|Bacteria 2|Bacteria E methyltransferase - - - - - - - - - - - - Acetyltransf_1,FAD_binding_4,Methyltransf_11,Methyltransf_25,Methyltransf_31,SAM_MT CMS1_k127_2824020_2 518766.Rmar_1442 5.626e-08 54.0 COG0577@1|root,COG0577@2|Bacteria,4NECN@976|Bacteroidetes,1FIY8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_2824020_0 1236902.ANAS01000005_gene4834 4.759e-51 189.0 COG0346@1|root,COG0346@2|Bacteria,2GRGB@201174|Actinobacteria 201174|Actinobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase_3 CMS1_k127_2824020_1 1379270.AUXF01000001_gene1880 1.789e-42 172.0 COG0823@1|root,COG3629@1|root,COG0823@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS1_k127_2838166_9 648996.Theam_0778 3.822e-05 56.0 COG3391@1|root,COG3391@2|Bacteria,2G4DB@200783|Aquificae 200783|Aquificae S NHL repeat containing protein - - - - - - - - - - - - DUF5128,NHL CMS1_k127_2838166_5 706587.Desti_5507 1.381e-69 264.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WM4S@28221|Deltaproteobacteria,2MRK9@213462|Syntrophobacterales 28221|Deltaproteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_2838166_3 452637.Oter_0320 1.813e-86 306.0 COG0577@1|root,COG0577@2|Bacteria,46U7K@74201|Verrucomicrobia,3K7M9@414999|Opitutae 74201|Verrucomicrobia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_2838166_4 452637.Oter_0321 1.032e-75 265.0 COG1136@1|root,COG1136@2|Bacteria,46SKR@74201|Verrucomicrobia,3K7HB@414999|Opitutae 2|Bacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_2838166_2 452637.Oter_0322 1.164e-92 319.0 COG0845@1|root,COG0845@2|Bacteria,46TJP@74201|Verrucomicrobia,3K7D1@414999|Opitutae 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_2838166_6 379066.GAU_2630 2.551e-19 102.0 COG1595@1|root,COG1595@2|Bacteria,1ZUGG@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_2838166_7 1379270.AUXF01000002_gene1587 2.95e-06 60.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1587|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_2838166_8 525373.HMPREF0766_12817 1.181e-05 58.0 COG3577@1|root,COG3577@2|Bacteria,4PGFR@976|Bacteroidetes,1ITP7@117747|Sphingobacteriia 976|Bacteroidetes S gag-polyprotein putative aspartyl protease - - - - - - - - - - - - Asp_protease_2,gag-asp_proteas CMS1_k127_2838166_0 29581.BW37_03833 5.551e-234 744.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2VHTT@28216|Betaproteobacteria,476KH@75682|Oxalobacteraceae 28216|Betaproteobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain f1pep1 - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N CMS1_k127_2838166_1 861299.J421_5836 3.192e-148 500.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_2856548_0 1340493.JNIF01000003_gene4405 2.643e-69 239.0 COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria 57723|Acidobacteria V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_2856548_1 861299.J421_6314 1.075e-46 180.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6314|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_2867742_1 379066.GAU_2950 3.438e-22 100.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,BTAD,TPR_12 CMS1_k127_2867742_2 861299.J421_4085 1.442e-16 94.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - - - - - - - - - - F5_F8_type_C,Flg_new,SLH,fn3 CMS1_k127_2897511_0 1122138.AQUZ01000008_gene3766 5.697e-76 255.0 COG0662@1|root,COG0662@2|Bacteria,2IRGP@201174|Actinobacteria 201174|Actinobacteria G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 CMS1_k127_2897511_4 1449069.JMLO01000055_gene2981 3.108e-08 58.0 2BD85@1|root,326WB@2|Bacteria,2HCG1@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_2897511_1 1242864.D187_004338 9.856e-75 265.0 COG1520@1|root,COG2863@1|root,COG3055@1|root,COG4676@1|root,COG1520@2|Bacteria,COG2863@2|Bacteria,COG3055@2|Bacteria,COG4676@2|Bacteria,1N3U2@1224|Proteobacteria,43AYV@68525|delta/epsilon subdivisions,2X6D5@28221|Deltaproteobacteria,2YYUW@29|Myxococcales 2|Bacteria C Kelch motif - - - - - - - - - - - - Calx-beta,Cytochrom_C,Cytochrome_CBB3,DUF5122,SBBP CMS1_k127_2897511_2 29581.BW37_04017 4.925e-31 134.0 COG2819@1|root,COG2819@2|Bacteria,1RB1X@1224|Proteobacteria,2VYUM@28216|Betaproteobacteria,4763T@75682|Oxalobacteraceae 28216|Betaproteobacteria S Putative esterase yuiI - - ko:K07017 - - - - ko00000 - - - Esterase CMS1_k127_2897511_3 1121011.AUCB01000034_gene893 4.645e-11 68.0 COG2133@1|root,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - - CMS1_k127_2904141_0 861299.J421_5759 3.768e-151 505.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2904141_3 82654.Pse7367_0266 2.036e-26 113.0 COG4741@1|root,COG4741@2|Bacteria 2|Bacteria F Endonuclease related to archaeal Holliday junction resolvase - - - - - - - - - - - - Endonuc_Holl CMS1_k127_2904141_4 381666.H16_A1706 3.814e-10 73.0 COG1404@1|root,COG1404@2|Bacteria,1REVZ@1224|Proteobacteria,2WDV2@28216|Betaproteobacteria,1KB1U@119060|Burkholderiaceae 28216|Betaproteobacteria O Subtilase family - - - ko:K17734 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S8 CMS1_k127_2904141_1 1051646.VITU9109_14061 3.145e-63 239.0 COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Pkd domain containing protein - - - - - - - - - - - - - CMS1_k127_2904141_2 1179778.PMM47T1_07621 5.183e-63 232.0 COG2199@1|root,COG3706@2|Bacteria,1RCJQ@1224|Proteobacteria,1RQUA@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF CMS1_k127_2913816_0 379066.GAU_2794 1.316e-129 439.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - DUF3857,Transglut_core CMS1_k127_2913816_3 861299.J421_2576 8.72e-05 50.0 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - CHAP,PG_binding_1 CMS1_k127_2913816_1 1196323.ALKF01000203_gene3817 1.15e-103 347.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - ChW,Peptidase_S8 CMS1_k127_2913816_2 985255.APHJ01000017_gene2168 2.119e-09 70.0 COG1409@1|root,COG1409@2|Bacteria,4P3GR@976|Bacteroidetes 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos CMS1_k127_2915036_1 349741.Amuc_0351 2.567e-142 456.0 COG0447@1|root,COG0447@2|Bacteria,46Z3Z@74201|Verrucomicrobia,2ITPX@203494|Verrucomicrobiae 203494|Verrucomicrobiae H Enoyl-CoA hydratase/isomerase menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_2915036_5 1123070.KB899249_gene437 7.776e-39 168.0 COG2267@1|root,COG2267@2|Bacteria,46WQX@74201|Verrucomicrobia,2IUN2@203494|Verrucomicrobiae 203494|Verrucomicrobiae I Alpha/beta hydrolase family - - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_6 CMS1_k127_2915036_2 1444711.CCJF01000005_gene1240 5.257e-128 433.0 COG1165@1|root,COG1165@2|Bacteria,2JG2A@204428|Chlamydiae 204428|Chlamydiae H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_N CMS1_k127_2915036_4 264201.pc1069 8.002e-45 175.0 COG1169@1|root,COG1169@2|Bacteria,2JG0M@204428|Chlamydiae 204428|Chlamydiae HQ Isochorismate synthase menF - 5.4.4.2 ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind CMS1_k127_2915036_3 290397.Adeh_3579 1.272e-83 295.0 COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2WKRY@28221|Deltaproteobacteria,2YUWB@29|Myxococcales 28221|Deltaproteobacteria S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase CMS1_k127_2915036_0 867903.ThesuDRAFT_00352 2.32e-193 627.0 COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis 186801|Clostridia C TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig CMS1_k127_2915036_6 887062.HGR_13939 2.252e-31 130.0 COG3216@1|root,COG3216@2|Bacteria,1N1Q6@1224|Proteobacteria 1224|Proteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) - - - - - - - - - - - - DUF2062 CMS1_k127_2915036_7 1121935.AQXX01000112_gene5699 5.894e-26 125.0 COG2982@1|root,COG2982@2|Bacteria,1P6EN@1224|Proteobacteria,1S1EC@1236|Gammaproteobacteria,1XKNN@135619|Oceanospirillales 135619|Oceanospirillales M Protein involved in outer membrane biogenesis - - - - - - - - - - - - - CMS1_k127_2916989_1 411154.GFO_3002 1.177e-41 165.0 COG1228@1|root,COG1228@2|Bacteria,4NGGD@976|Bacteroidetes,1I07B@117743|Flavobacteriia 976|Bacteroidetes Q amidohydrolase - - - - - - - - - - - - Amidohydro_1,SnoaL_2 CMS1_k127_2916989_0 518766.Rmar_1610 7.598e-46 185.0 COG2032@1|root,COG2032@2|Bacteria,4NM88@976|Bacteroidetes 976|Bacteroidetes P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodC - 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 - - - ko00000,ko00001,ko01000 - - - Sod_Cu CMS1_k127_2930511_0 880073.Calab_3321 0.0 1111.0 COG3696@1|root,COG3696@2|Bacteria,2NNKZ@2323|unclassified Bacteria 2|Bacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran CMS1_k127_2930511_2 379066.GAU_1315 8.095e-100 345.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cebB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23,HlyD_D4,YtkA CMS1_k127_2930511_4 379066.GAU_1316 2.42e-64 239.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity cebC - - - - - - - - - - - OEP CMS1_k127_2930511_5 861299.J421_1666 1.33e-57 218.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_2930511_1 886293.Sinac_3374 4.159e-248 779.0 COG0488@1|root,COG0488@2|Bacteria,2IWXR@203682|Planctomycetes 203682|Planctomycetes S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn CMS1_k127_2930511_7 1121405.dsmv_0001 1.109e-19 96.0 COG4843@1|root,COG4843@2|Bacteria,1REIP@1224|Proteobacteria,42S29@68525|delta/epsilon subdivisions,2WNWG@28221|Deltaproteobacteria,2MKCT@213118|Desulfobacterales 28221|Deltaproteobacteria S protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 CMS1_k127_2930511_6 404589.Anae109_2532 5.77e-28 113.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2Z1SJ@29|Myxococcales 28221|Deltaproteobacteria K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS1_k127_2930511_3 1278073.MYSTI_00528 8.115e-67 243.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2YWP2@29|Myxococcales 28221|Deltaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsA - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N CMS1_k127_2962608_6 861299.J421_2836 3.137e-54 201.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_2836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_2962608_9 1088869.GMO_12490 2.043e-20 105.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,2JS8T@204441|Rhodospirillales 204441|Rhodospirillales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase CMS1_k127_2962608_8 452637.Oter_3517 5.679e-39 163.0 COG0793@1|root,COG0793@2|Bacteria 2|Bacteria M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 CMS1_k127_2962608_1 1340493.JNIF01000004_gene652 3.672e-228 728.0 COG2274@1|root,COG2274@2|Bacteria 2|Bacteria V protein secretion by the type I secretion system - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran CMS1_k127_2962608_7 75379.Tint_0542 4.924e-40 156.0 COG2102@1|root,COG2102@2|Bacteria,1RIT6@1224|Proteobacteria,2VRZC@28216|Betaproteobacteria 28216|Betaproteobacteria S Diphthamide synthase - - - - - - - - - - - - Diphthami_syn_2 CMS1_k127_2962608_5 1249627.D779_0406 1.063e-58 226.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1WW2T@135613|Chromatiales 135613|Chromatiales G TIGRFAM HAD-superfamily subfamily IIA hydrolase like protein - - - - - - - - - - - - Hydrolase_6,Hydrolase_like CMS1_k127_2962608_4 937777.Deipe_0135 4.506e-63 225.0 COG0346@1|root,COG0400@1|root,COG0346@2|Bacteria,COG0400@2|Bacteria,1WICF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E glyoxalase bleomycin resistance protein dioxygenase - - - ko:K15975 - - - - ko00000 - - - Abhydrolase_2,Glyoxalase CMS1_k127_2962608_3 926690.KE386573_gene1707 8.935e-117 400.0 COG0477@1|root,arCOG00130@2157|Archaea,2XT8X@28890|Euryarchaeota,23TJU@183963|Halobacteria 183963|Halobacteria G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 CMS1_k127_2962608_10 680198.SCAB_44571 6.771e-20 104.0 COG0526@1|root,COG0526@2|Bacteria,2IJEI@201174|Actinobacteria 201174|Actinobacteria CO Glutathione peroxidase - - - - - - - - - - - - AhpC-TSA,Redoxin CMS1_k127_2962608_2 861299.J421_1620 2.191e-217 682.0 COG3669@1|root,COG3669@2|Bacteria,1ZURK@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos CMS1_k127_2962608_0 1047013.AQSP01000113_gene740 0.0 1041.0 COG1472@1|root,COG1472@2|Bacteria,2NNR4@2323|unclassified Bacteria 2|Bacteria G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 CMS1_k127_2970507_0 1191523.MROS_0791 8.993e-269 852.0 COG2217@1|root,COG2217@2|Bacteria 2|Bacteria P Heavy metal translocating P-type atpase copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS CMS1_k127_3018385_1 861299.J421_3986 3.77e-12 70.0 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pilE - - ko:K02456,ko:K02650,ko:K02655 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - ComP_DUS,N_methyl CMS1_k127_3018385_0 243231.GSU2508 5.319e-32 143.0 COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_16 CMS1_k127_3027255_15 861299.J421_3954 2.846e-37 152.0 2C0MY@1|root,30KW5@2|Bacteria,1ZTVN@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_3027255_17 1269813.ATUL01000022_gene778 3.9e-32 143.0 COG2199@1|root,COG3706@2|Bacteria,1NAG0@1224|Proteobacteria,1RPKX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - ko:K19707 - - - - ko00000,ko03021 - - - 7TMR-DISM_7TM,GAF,GGDEF,PAS_9,Response_reg,dCache_3 CMS1_k127_3027255_19 1408473.JHXO01000016_gene1935 1.368e-12 78.0 2D6WA@1|root,32TMZ@2|Bacteria,4NU16@976|Bacteroidetes,2FYYU@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 CMS1_k127_3027255_14 518766.Rmar_1768 4.097e-56 225.0 COG3225@1|root,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,1FJTM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux CMS1_k127_3027255_16 96561.Dole_2069 2.863e-33 150.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales 28221|Deltaproteobacteria N ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux CMS1_k127_3027255_10 1227739.Hsw_2741 1.284e-85 293.0 COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,47KF6@768503|Cytophagia 976|Bacteroidetes V TIGRFAM Gliding motility-associated ABC transporter ATP-binding subunit GldA gldA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_3027255_4 1121861.KB899946_gene3939 3.758e-144 466.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,2JR9U@204441|Rhodospirillales 204441|Rhodospirillales S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N CMS1_k127_3027255_11 330214.NIDE0494 1.453e-78 271.0 COG1573@1|root,COG1573@2|Bacteria 2|Bacteria L deaminated base DNA N-glycosylase activity udgB GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - DUF4130,UDG CMS1_k127_3027255_3 861299.J421_3955 3.057e-164 537.0 COG2204@1|root,COG2204@2|Bacteria,1ZSWY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat CMS1_k127_3027255_8 861299.J421_3957 3.88e-122 402.0 COG0404@1|root,COG0404@2|Bacteria,1ZTBZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C CMS1_k127_3027255_7 861299.J421_3960 1.723e-137 442.0 COG0078@1|root,COG0078@2|Bacteria,1ZT4K@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline - - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS1_k127_3027255_13 379066.GAU_2776 1.392e-71 263.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_3027255_1 861299.J421_3962 5.987e-182 582.0 COG1220@1|root,COG1220@2|Bacteria,1ZSVP@142182|Gemmatimonadetes 142182|Gemmatimonadetes O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small CMS1_k127_3027255_12 1379270.AUXF01000003_gene3407 1.411e-73 256.0 COG5405@1|root,COG5405@2|Bacteria,1ZSVH@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome CMS1_k127_3027255_9 861299.J421_3967 7.889e-89 321.0 COG4974@1|root,COG4974@2|Bacteria,1ZT3T@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Phage integrase, N-terminal SAM-like domain xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase CMS1_k127_3027255_2 861299.J421_3968 2.333e-173 554.0 COG1206@1|root,COG1206@2|Bacteria,1ZTB8@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs gid - 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA CMS1_k127_3027255_0 379066.GAU_2509 1.757e-272 857.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1ZTA9@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom CMS1_k127_3027255_18 1521187.JPIM01000050_gene3446 1.828e-24 118.0 COG0703@1|root,COG0703@2|Bacteria,2G9AN@200795|Chloroflexi,377HN@32061|Chloroflexia 32061|Chloroflexia F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI CMS1_k127_3027255_5 861299.J421_3974 4.8e-143 464.0 COG0082@1|root,COG0082@2|Bacteria,1ZT39@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt CMS1_k127_3027255_6 861299.J421_3976 1.874e-139 464.0 COG4796@1|root,COG4796@2|Bacteria,1ZSRT@142182|Gemmatimonadetes 142182|Gemmatimonadetes U AMIN domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,Secretin,Secretin_N CMS1_k127_303928_4 861299.J421_2170 2.698e-19 94.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_303928_5 1304865.JAGF01000001_gene3343 1.276e-12 76.0 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria 201174|Actinobacteria P Heavy metal translocating P-type atpase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS CMS1_k127_303928_3 1282876.BAOK01000001_gene2741 6.379e-38 151.0 COG4633@1|root,COG4633@2|Bacteria,1N1UQ@1224|Proteobacteria,2UEDS@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cupredoxin-like domain - - - - - - - - - - - - Cupredoxin_1 CMS1_k127_303928_0 1191523.MROS_0791 8.345e-225 719.0 COG2217@1|root,COG2217@2|Bacteria 2|Bacteria P Heavy metal translocating P-type atpase copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS CMS1_k127_303928_2 671143.DAMO_0820 5.678e-45 188.0 COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria 2|Bacteria C Rieske [2Fe-2S] domain petA - 1.10.2.2,1.10.9.1 ko:K00411,ko:K02636,ko:K03886 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - iAF987.Gmet_1922 CytB6-F_Fe-S,Rieske,UCR_Fe-S_N CMS1_k127_303928_6 1122622.ATWJ01000007_gene1692 6.926e-12 68.0 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4FF6K@85021|Intrasporangiaceae 201174|Actinobacteria P P-type ATPase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS CMS1_k127_303928_1 196162.Noca_2944 3.436e-58 217.0 COG1290@1|root,COG1290@2|Bacteria,2ICE4@201174|Actinobacteria 201174|Actinobacteria C Cytochrome b/b6/petB - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_N_2 CMS1_k127_3064900_0 234267.Acid_5004 5.627e-217 707.0 COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria 57723|Acidobacteria E Peptidase M14, carboxypeptidase A - - - - - - - - - - - - Peptidase_M14 CMS1_k127_3064900_1 547042.BACCOPRO_00170 2.403e-15 88.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,2FPGA@200643|Bacteroidia,4AKZ1@815|Bacteroidaceae 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,PDZ_2,Peptidase_S41,Tricorn_C1 CMS1_k127_3066359_35 861299.J421_4105 1.944e-07 62.0 COG5492@1|root,COG5492@2|Bacteria,1ZUA8@142182|Gemmatimonadetes 142182|Gemmatimonadetes N Bacterial Ig-like domain 2 - - - - - - - - - - - - Big_2 CMS1_k127_3066359_8 861299.J421_3119 3.412e-90 317.0 COG0438@1|root,COG0438@2|Bacteria,1ZTBC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_3066359_23 1210046.B277_11975 4.215e-47 184.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB,Methyltransf_23 CMS1_k127_3066359_36 443218.AS9A_0181 2.063e-06 55.0 COG0596@1|root,COG0596@2|Bacteria,2GKJB@201174|Actinobacteria,23610@1762|Mycobacteriaceae 201174|Actinobacteria S Haloalkane dehalogenase dhmA2 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_6 CMS1_k127_3066359_7 861299.J421_3108 7.558e-100 336.0 2F044@1|root,33T7T@2|Bacteria,1ZTDC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_3066359_28 984262.SGRA_2327 7.238e-29 127.0 COG0697@1|root,COG0697@2|Bacteria,4NGZ3@976|Bacteroidetes 976|Bacteroidetes EG Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA CMS1_k127_3066359_2 1047013.AQSP01000105_gene1455 7.64e-156 501.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_3066359_39 1128421.JAGA01000003_gene2825 6.847e-06 58.0 2EM0B@1|root,33EPU@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_3066359_12 479432.Sros_1916 3.189e-81 276.0 COG0778@1|root,COG0778@2|Bacteria,2GPB4@201174|Actinobacteria,4EPBI@85012|Streptosporangiales 201174|Actinobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase CMS1_k127_3066359_27 1237149.C900_03635 6.208e-30 134.0 2C1XD@1|root,340CH@2|Bacteria,4P45P@976|Bacteroidetes 976|Bacteroidetes S Putative lumazine-binding - - - - - - - - - - - - Lumazine_bd_2 CMS1_k127_3066359_25 1232410.KI421415_gene3041 2.92e-36 154.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,43S3D@69541|Desulfuromonadales 28221|Deltaproteobacteria D TilS substrate binding domain tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C CMS1_k127_3066359_16 1379270.AUXF01000005_gene655 3.703e-73 250.0 COG0634@1|root,COG0634@2|Bacteria,1ZTH7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Phosphoribosyl transferase domain - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran CMS1_k127_3066359_1 861299.J421_3042 8.639e-274 856.0 COG0465@1|root,COG0465@2|Bacteria,1ZSRI@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,Peptidase_M41 CMS1_k127_3066359_18 404589.Anae109_2337 3.697e-68 259.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria,2YVIZ@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind CMS1_k127_3066359_14 861299.J421_3044 1.12e-78 271.0 COG1624@1|root,COG1624@2|Bacteria,1ZUI8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N CMS1_k127_3066359_10 861299.J421_2988 1.01e-85 315.0 COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_3066359_20 861299.J421_3047 2.088e-62 222.0 COG0325@1|root,COG3599@1|root,COG0325@2|Bacteria,COG3599@2|Bacteria,1ZTJZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N CMS1_k127_3066359_30 379066.GAU_1397 2.484e-24 111.0 COG3599@1|root,COG3599@2|Bacteria,1ZUSD@142182|Gemmatimonadetes 142182|Gemmatimonadetes D DivIVA protein - - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA CMS1_k127_3066359_0 861299.J421_3048 0.0 1060.0 COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 CMS1_k127_3066359_22 861299.J421_3049 1.73e-56 200.0 COG1734@1|root,COG1734@2|Bacteria,1ZTP9@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR CMS1_k127_3066359_24 379066.GAU_1401 3.828e-45 173.0 COG0597@1|root,COG0597@2|Bacteria,1ZTWA@142182|Gemmatimonadetes 142182|Gemmatimonadetes M This protein specifically catalyzes the removal of signal peptides from prolipoproteins - - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 CMS1_k127_3066359_17 867845.KI911784_gene1549 1.096e-68 250.0 COG0564@1|root,COG0564@2|Bacteria,2G68N@200795|Chloroflexi,3758V@32061|Chloroflexia 32061|Chloroflexia J Responsible for synthesis of pseudouridine from uracil - GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 CMS1_k127_3066359_32 1380356.JNIK01000019_gene459 5.236e-10 68.0 COG0835@1|root,COG0835@2|Bacteria,2IQJ0@201174|Actinobacteria,4ET76@85013|Frankiales 201174|Actinobacteria NT Two component signalling adaptor domain cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW CMS1_k127_3066359_21 379066.GAU_1405 1.329e-60 210.0 COG2204@1|root,COG2204@2|Bacteria,1ZTMH@142182|Gemmatimonadetes 142182|Gemmatimonadetes T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg CMS1_k127_3066359_3 379066.GAU_1406 1.084e-135 454.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1ZT7R@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT P2 response regulator binding domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 CMS1_k127_3066359_19 1379270.AUXF01000005_gene669 3.158e-66 231.0 COG1776@1|root,COG1776@2|Bacteria,1ZTIW@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT CheC-like family - - - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC CMS1_k127_3066359_5 1379270.AUXF01000005_gene670 3.376e-120 425.0 COG0457@1|root,COG0457@2|Bacteria,1ZSS6@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 CMS1_k127_3066359_26 316274.Haur_0845 7.517e-33 142.0 COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi,374ST@32061|Chloroflexia 32061|Chloroflexia S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388 CMS1_k127_3066359_33 382464.ABSI01000017_gene107 6.903e-09 66.0 COG0457@1|root,COG0457@2|Bacteria 382464.ABSI01000017_gene107|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_3066359_40 765420.OSCT_2807 0.0001942 53.0 COG2018@1|root,COG2018@2|Bacteria,2G9R6@200795|Chloroflexi,375PX@32061|Chloroflexia 32061|Chloroflexia S PFAM Roadblock LC7 family protein - - - ko:K07131 - - - - ko00000 - - - Robl_LC7 CMS1_k127_3066359_37 1379698.RBG1_1C00001G1744 2.529e-06 59.0 COG2018@1|root,COG2018@2|Bacteria,2NQXH@2323|unclassified Bacteria 2|Bacteria S Roadblock/LC7 domain mglB - - - - - - - - - - - Robl_LC7 CMS1_k127_3066359_15 861299.J421_3059 3.333e-76 264.0 COG1100@1|root,COG1100@2|Bacteria,1ZTK3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Small GTP-binding protein - - - ko:K06883 - - - - ko00000 - - - Arf CMS1_k127_3066359_6 1379270.AUXF01000005_gene673 1.222e-112 390.0 COG0593@1|root,COG0593@2|Bacteria,1ZUFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bacterial dnaA protein - - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA CMS1_k127_3066359_4 1379270.AUXF01000005_gene674 9.538e-124 436.0 COG0457@1|root,COG0457@2|Bacteria,1ZSPN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388,TPR_16,TPR_2 CMS1_k127_3066359_11 861299.J421_3062 1.258e-84 291.0 COG1352@1|root,COG1352@2|Bacteria 2|Bacteria NT protein-glutamate O-methyltransferase activity cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N CMS1_k127_3066359_29 555079.Toce_1124 2.664e-28 129.0 COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia,42GBK@68295|Thermoanaerobacterales 186801|Clostridia NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD CMS1_k127_3066359_9 1379270.AUXF01000005_gene676 8.189e-86 301.0 COG2201@1|root,COG2201@2|Bacteria,1ZUFV@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg CMS1_k127_3066359_31 632518.Calow_0440 4.259e-18 96.0 COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,42GKD@68295|Thermoanaerobacterales 186801|Clostridia NT PFAM CheW domain protein cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW CMS1_k127_3066359_13 1379270.AUXF01000005_gene678 1.335e-80 285.0 COG0457@1|root,COG0457@2|Bacteria,1ZTK5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2 CMS1_k127_3066359_38 679926.Mpet_2603 2.727e-06 60.0 COG0457@1|root,arCOG03042@1|root,arCOG03038@2157|Archaea,arCOG03042@2157|Archaea,2Y021@28890|Euryarchaeota 28890|Euryarchaeota S repeat-containing protein - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 CMS1_k127_3077535_6 1432050.IE4771_CH01154 2.663e-112 366.0 COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,2TVNH@28211|Alphaproteobacteria,4B8Y7@82115|Rhizobiaceae 28211|Alphaproteobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_31 CMS1_k127_3077535_13 861299.J421_6105 2.62e-60 233.0 COG0308@1|root,COG0739@1|root,COG0308@2|Bacteria,COG0739@2|Bacteria 2|Bacteria M heme binding - - - ko:K08642,ko:K21472 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Cu_amine_oxidN1,Peptidase_M1,Peptidase_M23 CMS1_k127_3077535_21 1151122.AQYD01000007_gene68 3.397e-11 74.0 COG1725@1|root,COG1725@2|Bacteria,2IHTD@201174|Actinobacteria,4FQ3H@85023|Microbacteriaceae 201174|Actinobacteria K helix_turn_helix gluconate operon transcriptional repressor - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR CMS1_k127_3077535_12 926549.KI421517_gene1458 2.601e-65 234.0 COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes,47PEN@768503|Cytophagia 976|Bacteroidetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 CMS1_k127_3077535_14 749414.SBI_02860 5.226e-37 161.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,2GMNT@201174|Actinobacteria 201174|Actinobacteria U Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_3077535_1 1380600.AUYN01000001_gene2799 1.545e-225 728.0 COG3540@1|root,COG3540@2|Bacteria,4NFXQ@976|Bacteroidetes,1HY2S@117743|Flavobacteriia 976|Bacteroidetes P PhoD-like phosphatase - - - - - - - - - - - - PhoD CMS1_k127_3077535_4 530564.Psta_4258 7.905e-157 511.0 COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase CMS1_k127_3077535_10 439235.Dalk_5049 4.202e-85 293.0 COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,42QRA@68525|delta/epsilon subdivisions,2WN1V@28221|Deltaproteobacteria,2MK22@213118|Desulfobacterales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B CMS1_k127_3077535_3 485913.Krac_5920 5.021e-175 571.0 COG0641@1|root,COG0641@2|Bacteria,2G74V@200795|Chloroflexi 200795|Chloroflexi C Iron-sulfur cluster-binding domain - - - ko:K06871 - - - - ko00000 - - - Radical_SAM,SPASM CMS1_k127_3077535_9 1163617.SCD_n02012 4.545e-93 319.0 COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria 28216|Betaproteobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 CMS1_k127_3077535_16 379066.GAU_3378 1.498e-32 137.0 2DCAE@1|root,2ZDF3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_3077535_15 1197906.CAJQ02000047_gene4077 7.249e-36 140.0 COG2329@1|root,COG2329@2|Bacteria,1N2ZS@1224|Proteobacteria,2UEPY@28211|Alphaproteobacteria,3K08M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - - CMS1_k127_3077535_18 234267.Acid_3247 1.719e-22 107.0 294EW@1|root,2ZRUR@2|Bacteria,3Y5CG@57723|Acidobacteria 57723|Acidobacteria S Protein of unknown function (DUF1569) - - - - - - - - - - - - DUF1569 CMS1_k127_3077535_20 742767.HMPREF9456_02434 1.954e-12 72.0 COG4319@1|root,COG4319@2|Bacteria,4NT6G@976|Bacteroidetes,2FTV9@200643|Bacteroidia,22YRG@171551|Porphyromonadaceae 976|Bacteroidetes S Calcium/calmodulin dependent protein kinase II association domain - - - - - - - - - - - - DUF4440 CMS1_k127_3077535_2 502025.Hoch_1577 1.82e-188 620.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1P64D@1224|Proteobacteria,439PY@68525|delta/epsilon subdivisions,2X51T@28221|Deltaproteobacteria,2YZZT@29|Myxococcales 28221|Deltaproteobacteria KLTU Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_3077535_8 1267535.KB906767_gene1445 2.059e-98 327.0 2CDZB@1|root,2ZBFS@2|Bacteria,3Y5HH@57723|Acidobacteria,2JM8W@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - CMS1_k127_3077535_19 221288.JH992901_gene3767 9.268e-21 108.0 COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria 1117|Cyanobacteria U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS1_k127_3077535_17 1169161.KB897734_gene357 1.081e-27 128.0 2CE4Q@1|root,2Z7WX@2|Bacteria,2H0P6@201174|Actinobacteria 201174|Actinobacteria S Arylsulfotransferase (ASST) - - - - - - - - - - - - Arylsulfotran_2 CMS1_k127_3077535_5 1499967.BAYZ01000065_gene6086 4.97e-153 490.0 COG3938@1|root,COG3938@2|Bacteria,2NQES@2323|unclassified Bacteria 2|Bacteria E Proline racemase - GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0050346,GO:0071704,GO:1901564 5.1.1.4 ko:K01777 ko00330,ko01100,map00330,map01100 - R01255 RC00479 ko00000,ko00001,ko01000 - - - Pro_racemase CMS1_k127_3077535_11 644966.Tmar_0600 1.695e-77 272.0 COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,24DP8@186801|Clostridia,3WD65@538999|Clostridiales incertae sedis 186801|Clostridia E Ornithine cyclodeaminase/mu-crystallin family ocd - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall CMS1_k127_3077535_7 1379270.AUXF01000004_gene2929 2.452e-106 363.0 COG0451@1|root,COG0451@2|Bacteria,1ZUAM@142182|Gemmatimonadetes 142182|Gemmatimonadetes GM NAD dependent epimerase/dehydratase family - - 1.3.1.45 ko:K05281 ko00943,ko01110,map00943,map01110 - R06562,R06563,R07747,R07751 RC00805 ko00000,ko00001,ko01000 - - - Epimerase CMS1_k127_3077535_22 283699.D172_3269 6.563e-06 57.0 2EXFA@1|root,33QRQ@2|Bacteria,1NSAC@1224|Proteobacteria,1SM6V@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_3077535_0 504472.Slin_3267 1.046e-305 947.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NFTM@976|Bacteroidetes,47NS1@768503|Cytophagia 976|Bacteroidetes EU Dienelactone hydrolase family - - - - - - - - - - - - DPPIV_N,PD40,Peptidase_S9 CMS1_k127_308216_1 1379270.AUXF01000004_gene3168 2.188e-108 384.0 2DBB2@1|root,2Z858@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_308216_0 1379270.AUXF01000004_gene3169 8.159e-152 507.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug,TonB_dep_Rec CMS1_k127_3091876_2 1118153.MOY_12734 1.522e-06 55.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XIG8@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_3091876_1 547559.Nmag_3404 1.39e-43 175.0 arCOG10603@1|root,arCOG10603@2157|Archaea,2XWSN@28890|Euryarchaeota,23VC9@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - CMS1_k127_3091876_0 861299.J421_2852 1.403e-109 388.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_2852|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_3112540_0 1121904.ARBP01000003_gene6496 3.225e-241 772.0 COG0308@1|root,COG0308@2|Bacteria,4NGTZ@976|Bacteroidetes,47MWS@768503|Cytophagia 976|Bacteroidetes E Peptidase family M1 domain pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 CMS1_k127_3112540_3 1469245.JFBG01000083_gene243 5.692e-46 171.0 COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1T12G@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxin - - - - - - - - - - - - - CMS1_k127_3112540_1 1125863.JAFN01000001_gene2573 6.138e-75 267.0 COG1283@1|root,COG1283@2|Bacteria,1MXWU@1224|Proteobacteria 1224|Proteobacteria P phosphate symporter nptA - - ko:K14683 - - - - ko00000,ko02000,ko04147 2.A.58.1 - - Na_Pi_cotrans CMS1_k127_3112540_4 187272.Mlg_1738 3.941e-23 108.0 COG0704@1|root,COG0704@2|Bacteria,1NRGK@1224|Proteobacteria,1SMQP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PhoU domain - - - - - - - - - - - - PhoU CMS1_k127_3112540_2 644966.Tmar_0252 1.509e-66 243.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRT@186801|Clostridia 186801|Clostridia P Rhodanese Homology Domain - - - - - - - - - - - - Lactamase_B,Rhodanese CMS1_k127_315897_11 861299.J421_3615 4.721e-17 90.0 COG0848@1|root,COG0848@2|Bacteria,1ZTXP@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD CMS1_k127_315897_2 251221.35212995 1.955e-93 336.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_315897_13 861299.J421_4087 1.273e-14 89.0 COG3408@1|root,COG3459@1|root,COG3408@2|Bacteria,COG3459@2|Bacteria 2|Bacteria G carbohydrate binding cbpA - 2.4.1.333 ko:K21298 - - - - ko00000,ko01000 - GH94 - BNR_2,F5_F8_type_C,Glyco_hydro_36,Glyco_transf_36,Trehalase CMS1_k127_315897_6 13690.CP98_00034 7.209e-45 186.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TRTE@28211|Alphaproteobacteria,2K0PD@204457|Sphingomonadales 204457|Sphingomonadales EU Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_315897_5 1123008.KB905696_gene2996 1.181e-63 229.0 COG0596@1|root,COG0596@2|Bacteria,4NN2I@976|Bacteroidetes 976|Bacteroidetes S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 CMS1_k127_315897_3 649747.HMPREF0083_00801 1.763e-78 274.0 COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,4H9PJ@91061|Bacilli,26R2G@186822|Paenibacillaceae 91061|Bacilli S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA_2 - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase CMS1_k127_315897_1 1267535.KB906767_gene4657 3.873e-134 443.0 COG3852@1|root,COG3852@2|Bacteria,3Y3JR@57723|Acidobacteria,2JIY1@204432|Acidobacteriia 204432|Acidobacteriia T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HATPase_c,cNMP_binding CMS1_k127_315897_14 1242864.D187_000759 1.417e-05 58.0 COG3797@1|root,COG3797@2|Bacteria,1N0SN@1224|Proteobacteria,431H7@68525|delta/epsilon subdivisions,2WWTH@28221|Deltaproteobacteria,2Z202@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF1697) - - - - - - - - - - - - DUF1697 CMS1_k127_315897_4 1279017.AQYJ01000024_gene1001 8.664e-66 244.0 COG0793@1|root,COG0793@2|Bacteria 2|Bacteria M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S41,TPR_8,Tricorn_C1 CMS1_k127_315897_7 760117.JN27_23170 4.285e-39 160.0 arCOG10603@1|root,32SV6@2|Bacteria,1MYDK@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_315897_9 1235835.C814_02225 2.502e-32 131.0 COG5485@1|root,COG5485@2|Bacteria,1V4VN@1239|Firmicutes,24IWY@186801|Clostridia 186801|Clostridia S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL CMS1_k127_315897_10 56110.Oscil6304_4237 3.472e-30 127.0 2CDPE@1|root,32UIJ@2|Bacteria,1G8EB@1117|Cyanobacteria,1HCG3@1150|Oscillatoriales 1117|Cyanobacteria S Protein of unknown function (DUF2809) - - - - - - - - - - - - DUF2809 CMS1_k127_315897_12 502025.Hoch_1577 7.768e-17 95.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1P64D@1224|Proteobacteria,439PY@68525|delta/epsilon subdivisions,2X51T@28221|Deltaproteobacteria,2YZZT@29|Myxococcales 28221|Deltaproteobacteria KLTU Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_315897_0 1379270.AUXF01000005_gene333 1.792e-192 612.0 COG0534@1|root,COG0534@2|Bacteria,1ZT8D@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MatE - - - - - - - - - - - - MatE CMS1_k127_3175384_9 861299.J421_3332 2.449e-44 169.0 COG0584@1|root,COG0584@2|Bacteria,1ZTTY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD CMS1_k127_3175384_3 391625.PPSIR1_25066 4.781e-89 312.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42PBC@68525|delta/epsilon subdivisions,2WM7S@28221|Deltaproteobacteria,2YY2B@29|Myxococcales 28221|Deltaproteobacteria C 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N CMS1_k127_3175384_5 1121468.AUBR01000026_gene2914 2.902e-73 265.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42EVN@68295|Thermoanaerobacterales 186801|Clostridia I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 CMS1_k127_3175384_1 861299.J421_5582 3.907e-106 366.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase bamU - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 CMS1_k127_3175384_0 379731.PST_2511 1.569e-110 382.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,1Z0XV@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria P Anion transporter sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp CMS1_k127_3175384_11 404589.Anae109_0402 1.985e-36 148.0 COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,42UHB@68525|delta/epsilon subdivisions,2WQHM@28221|Deltaproteobacteria,2YVPY@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF423) - - - - - - - - - - - - DUF423 CMS1_k127_3175384_4 309807.SRU_0542 1.006e-78 274.0 COG0115@1|root,COG0115@2|Bacteria,4NI83@976|Bacteroidetes 976|Bacteroidetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 CMS1_k127_3175384_2 1122179.KB890458_gene744 1.511e-96 333.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1IPY5@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_3175384_7 1123057.P872_23335 1.614e-68 258.0 COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,47M2G@768503|Cytophagia 976|Bacteroidetes S Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_3175384_6 861299.J421_1666 1.97e-69 259.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_3175384_10 215803.DB30_4178 1.92e-38 168.0 COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales 28221|Deltaproteobacteria O Fibronectin type 3 domain - - - - - - - - - - - - Peptidase_M6,Peptidase_S8 CMS1_k127_3175384_8 765869.BDW_04655 6.145e-67 261.0 COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria 1224|Proteobacteria DZ Alpha-tubulin suppressor and related RCC1 domain-containing - - - - - - - - - - - - He_PIG,RCC1,RCC1_2 CMS1_k127_3175384_12 504728.K649_01455 3.596e-23 113.0 COG2706@1|root,COG2931@1|root,COG5492@1|root,COG2706@2|Bacteria,COG2931@2|Bacteria,COG5492@2|Bacteria,1WNFY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus NQ Bacterial Ig-like domain 2 - - - - - - - - - - - - Big_2 CMS1_k127_3175384_13 1380390.JIAT01000013_gene144 1.918e-06 60.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - ko:K07004,ko:K09955 - - - - ko00000 - - - Big_4,CW_binding_1,DUF1929,F5_F8_type_C,FIVAR,He_PIG,Laminin_G_3,Peptidase_M6 CMS1_k127_3193927_2 1379270.AUXF01000002_gene1589 1.78e-90 307.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3193927_1 861299.J421_0468 1.307e-109 392.0 COG0515@1|root,COG0515@2|Bacteria,1ZUHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_3193927_0 1305737.JAFX01000001_gene1928 3.076e-282 898.0 COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes 976|Bacteroidetes E Peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - Peptidase_S9 CMS1_k127_3193927_3 1185876.BN8_00646 5.618e-87 306.0 COG0739@1|root,COG0739@2|Bacteria,4NEBZ@976|Bacteroidetes,47JJ1@768503|Cytophagia 976|Bacteroidetes M Peptidase family M23 - - - ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23,SH3_3,SH3_4 CMS1_k127_3197860_0 861299.J421_1402 4.043e-273 855.0 COG2091@1|root,COG2091@2|Bacteria,1ZUPU@142182|Gemmatimonadetes 2|Bacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 CMS1_k127_3197860_1 861299.J421_4105 2.478e-09 70.0 COG5492@1|root,COG5492@2|Bacteria,1ZUA8@142182|Gemmatimonadetes 142182|Gemmatimonadetes N Bacterial Ig-like domain 2 - - - - - - - - - - - - Big_2 CMS1_k127_3276867_1 485913.Krac_7712 4.686e-48 177.0 COG1051@1|root,COG1051@2|Bacteria,2G9CK@200795|Chloroflexi 200795|Chloroflexi F PFAM NUDIX hydrolase - - - - - - - - - - - - NUDIX CMS1_k127_3276867_0 379066.GAU_0591 7.785e-90 317.0 COG4206@1|root,COG4206@2|Bacteria,1ZUAE@142182|Gemmatimonadetes 142182|Gemmatimonadetes H TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug CMS1_k127_3395818_0 861299.J421_6141 1.452e-136 467.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6141|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_3395818_1 1379270.AUXF01000001_gene1925 2.533e-46 176.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K17285 - - - - ko00000,ko04147 - - - SBP56,SHD1 CMS1_k127_3395818_2 195250.CM001776_gene2766 0.0001259 48.0 COG4636@1|root,COG4636@2|Bacteria 2|Bacteria D protein conserved in cyanobacteria - - - - - - - - - - - - Uma2 CMS1_k127_3395818_3 1032480.MLP_34200 0.0005679 45.0 COG4636@1|root,COG4636@2|Bacteria 2|Bacteria D protein conserved in cyanobacteria - - - - - - - - - - - - Uma2 CMS1_k127_3428927_1 379066.GAU_2035 3.95e-77 263.0 COG5557@1|root,COG5557@2|Bacteria,1ZSN2@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD CMS1_k127_3428927_7 316067.Geob_0866 1.833e-24 111.0 COG2010@1|root,COG5557@1|root,COG2010@2|Bacteria,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,43SBI@69541|Desulfuromonadales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD moz - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD CMS1_k127_3428927_8 379066.GAU_2033 1.981e-22 106.0 COG2010@1|root,COG2010@2|Bacteria,1ZTPK@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 CMS1_k127_3428927_2 861299.J421_3626 9.244e-62 231.0 COG5557@1|root,COG5557@2|Bacteria,1ZTCE@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pfam Polysulphide reductase, NrfD - - - - - - - - - - - - - CMS1_k127_3428927_4 861299.J421_2342 4.132e-46 170.0 COG0599@1|root,COG0599@2|Bacteria,1ZTRJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD CMS1_k127_3428927_3 909663.KI867150_gene596 2.803e-49 190.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria,2MQHC@213462|Syntrophobacterales 28221|Deltaproteobacteria O XdhC and CoxI family - - - ko:K07402 - - - - ko00000 - - - NTP_transf_3,XdhC_C,XdhC_CoxI CMS1_k127_3428927_6 861299.J421_0278 1.207e-27 123.0 COG4636@1|root,COG4636@2|Bacteria,1ZUYJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative restriction endonuclease - - - - - - - - - - - - Uma2 CMS1_k127_3428927_5 861299.J421_0442 7.054e-32 130.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_3428927_0 926550.CLDAP_34140 1.44e-109 382.0 COG2304@1|root,COG2304@2|Bacteria,2G7VX@200795|Chloroflexi 200795|Chloroflexi S VWA domain containing CoxE-like protein - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA CMS1_k127_3477163_0 1047013.AQSP01000079_gene2041 5.285e-117 398.0 COG0841@1|root,COG0841@2|Bacteria,2NQI6@2323|unclassified Bacteria 2|Bacteria V AcrB/AcrD/AcrF family mdtC - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran CMS1_k127_3553330_3 1223542.GM1_019_00130 5.831e-22 104.0 COG1309@1|root,COG1309@2|Bacteria,2GP91@201174|Actinobacteria,4GAVW@85026|Gordoniaceae 201174|Actinobacteria K WHG domain - - - - - - - - - - - - TetR_N,WHG CMS1_k127_3553330_1 1121930.AQXG01000001_gene1200 1.333e-56 222.0 COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS1_k127_3553330_2 518766.Rmar_0880 4.684e-56 211.0 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1FJ10@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 CMS1_k127_3553330_0 1121104.AQXH01000001_gene2028 8.558e-178 569.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IQYT@117747|Sphingobacteriia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran CMS1_k127_3597859_14 861299.J421_1760 6.537e-21 100.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_3597859_17 1250278.JQNQ01000001_gene3232 7.313e-15 82.0 COG1633@1|root,COG1633@2|Bacteria,4NFAU@976|Bacteroidetes 976|Bacteroidetes S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - - - - - - - - - - - CMS1_k127_3597859_11 452637.Oter_2162 6.595e-56 219.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4,6.3.5.5 ko:K01921,ko:K01955 ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502 M00051 R00256,R00575,R01150,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Dala_Dala_lig_C CMS1_k127_3597859_2 251221.35214024 7.786e-160 522.0 COG0591@1|root,COG0591@2|Bacteria,1G1JV@1117|Cyanobacteria 1117|Cyanobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - - - - - - - - - - SSF CMS1_k127_3597859_7 357808.RoseRS_3163 3.251e-92 314.0 COG3804@1|root,COG3804@2|Bacteria,2G7MJ@200795|Chloroflexi 200795|Chloroflexi C Dihydrodipicolinate reductase, N-terminus - - 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 - R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 - - - DapB_N CMS1_k127_3597859_15 640512.BC1003_2626 1.589e-16 92.0 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VR7H@28216|Betaproteobacteria,1K1TE@119060|Burkholderiaceae 28216|Betaproteobacteria M repeat-containing protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 CMS1_k127_3597859_6 404589.Anae109_3404 1.143e-99 361.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2YUPC@29|Myxococcales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family crdA - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_3597859_13 204669.Acid345_1733 1.398e-35 157.0 COG5000@1|root,COG5000@2|Bacteria,3Y32D@57723|Acidobacteria,2JIN2@204432|Acidobacteriia 2|Bacteria T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA CMS1_k127_3597859_18 1203190.CAJP01000005_gene1588 8.723e-09 68.0 COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,22M2K@1653|Corynebacteriaceae 201174|Actinobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 CMS1_k127_3597859_12 861299.J421_1614 4.996e-43 165.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family yjoA - - - - - - - - - - - DinB,DinB_2 CMS1_k127_3597859_10 1242864.D187_005496 6.238e-58 219.0 COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,42UK8@68525|delta/epsilon subdivisions,2WQG7@28221|Deltaproteobacteria,2Z0U2@29|Myxococcales 28221|Deltaproteobacteria CG UDP-glucoronosyl and UDP-glucosyl transferase - - 2.4.1.310 ko:K16444 ko01055,map01055 - - - ko00000,ko00001,ko01000 - GT1 - Glyco_transf_28,UDPGT CMS1_k127_3597859_9 756067.MicvaDRAFT_1008 2.42e-63 227.0 COG0400@1|root,COG0400@2|Bacteria,1G3RX@1117|Cyanobacteria 1117|Cyanobacteria S PFAM phospholipase Carboxylesterase - - - - - - - - - - - - Abhydrolase_2,Esterase CMS1_k127_3597859_4 891968.Anamo_2039 1.279e-121 400.0 COG1883@1|root,COG1883@2|Bacteria,3T9TE@508458|Synergistetes 508458|Synergistetes C TIGRFAM sodium ion-translocating decarboxylase, beta subunit gcdB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta CMS1_k127_3597859_3 177439.DP0686 1.113e-128 435.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,43BUE@68525|delta/epsilon subdivisions,2X75I@28221|Deltaproteobacteria,2MPKE@213118|Desulfobacterales 28221|Deltaproteobacteria C Conserved carboxylase domain - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA CMS1_k127_3597859_16 1122918.KB907284_gene1224 4.032e-15 88.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4HB60@91061|Bacilli,26QTA@186822|Paenibacillaceae 91061|Bacilli K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 CMS1_k127_3597859_0 1047013.AQSP01000089_gene1176 2.889e-199 636.0 COG2866@1|root,COG2866@2|Bacteria,2NQT6@2323|unclassified Bacteria 2|Bacteria E Zn_pept - - - - - - - - - - - - Peptidase_M14 CMS1_k127_3597859_5 1382306.JNIM01000001_gene28 2.015e-114 395.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,2G8BR@200795|Chloroflexi 200795|Chloroflexi IQ TIGRFAM rhamnulose-1-phosphate aldolase alcohol dehydrogenase - - - - - - - - - - - - Aldolase_II,adh_short_C2 CMS1_k127_3597859_1 518766.Rmar_0118 5.238e-160 521.0 COG2939@1|root,COG2939@2|Bacteria,4NF48@976|Bacteroidetes,1FJ5Z@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 CMS1_k127_3597859_8 1379270.AUXF01000001_gene2556 1.385e-77 271.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000001_gene2556|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3611816_1 1192034.CAP_5611 1.203e-28 118.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42SQU@68525|delta/epsilon subdivisions,2WPRP@28221|Deltaproteobacteria,2YUSU@29|Myxococcales 28221|Deltaproteobacteria C [2Fe-2S] binding domain - - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 CMS1_k127_3611816_0 1250232.JQNJ01000001_gene3316 5.97e-75 264.0 COG1409@1|root,COG1409@2|Bacteria,4NF9K@976|Bacteroidetes,1HY33@117743|Flavobacteriia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,MetallophosC,MetallophosN CMS1_k127_3623189_1 1439940.BAY1663_01020 1.626e-07 53.0 COG2197@1|root,COG2197@2|Bacteria,1MXI3@1224|Proteobacteria,1RNEY@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - ko:K04333 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - GerE CMS1_k127_3623189_0 404589.Anae109_1755 8.105e-123 413.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,43C89@68525|delta/epsilon subdivisions,2X7IN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 CMS1_k127_3643734_0 1122138.AQUZ01000004_gene1005 8.169e-103 346.0 COG4695@1|root,COG4695@2|Bacteria,2I9PX@201174|Actinobacteria,4DWCY@85009|Propionibacteriales 201174|Actinobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal CMS1_k127_3643734_2 1064537.AGSO01000002_gene214 1.517e-36 151.0 COG0740@1|root,COG0740@2|Bacteria,2IGS3@201174|Actinobacteria 201174|Actinobacteria OU Belongs to the peptidase S14 family clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease,Mu-like_Pro CMS1_k127_3643734_1 1122138.AQUZ01000004_gene1046 2.524e-69 247.0 COG0740@1|root,COG4653@1|root,COG0740@2|Bacteria,COG4653@2|Bacteria,2HZB6@201174|Actinobacteria,4DVIV@85009|Propionibacteriales 201174|Actinobacteria OU Phage capsid family - - - - - - - - - - - - Phage_capsid CMS1_k127_365385_2 313606.M23134_06002 1.811e-25 116.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity srrB - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,CBS,HAMP,SpoIIE,TPR_12,TPR_8,Y_Y_Y,dCache_1 CMS1_k127_365385_1 73044.JNXP01000007_gene5440 7.475e-56 200.0 COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,cNMP_binding CMS1_k127_365385_0 861299.J421_5836 1.061e-101 356.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_3662138_0 398767.Glov_0337 4.166e-106 363.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM magnesium chelatase ChlI subunit comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C CMS1_k127_3662138_1 556269.ACDQ01000006_gene1601 9.765e-15 80.0 COG3728@1|root,COG3728@2|Bacteria,1NEAA@1224|Proteobacteria,2WFUB@28216|Betaproteobacteria 28216|Betaproteobacteria L Terminase small subunit - - - ko:K07474 - - - - ko00000 - - - Terminase_2 CMS1_k127_3668572_0 1379270.AUXF01000001_gene2161 0.0 1755.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C CMS1_k127_3668572_1 1049564.TevJSym_aq00710 2.068e-26 113.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,RnfC_N,SLBB CMS1_k127_3670648_0 765869.BDW_04655 6.231e-66 244.0 COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria 1224|Proteobacteria DZ Alpha-tubulin suppressor and related RCC1 domain-containing - - - - - - - - - - - - He_PIG,RCC1,RCC1_2 CMS1_k127_3676176_0 378806.STAUR_3085 2.722e-19 103.0 COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales 28221|Deltaproteobacteria O Fibronectin type 3 domain - - - - - - - - - - - - Peptidase_M6,Peptidase_S8 CMS1_k127_3687356_4 1123368.AUIS01000008_gene2251 2.944e-21 94.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,2NCIJ@225057|Acidithiobacillales 225057|Acidithiobacillales KO Hydrogenase accessory protein HypB - - - ko:K04652 - - - - ko00000,ko03110 - - - cobW CMS1_k127_3687356_0 326427.Cagg_0466 1.117e-195 638.0 COG0068@1|root,COG0068@2|Bacteria,2G5QN@200795|Chloroflexi,3767R@32061|Chloroflexia 32061|Chloroflexia O TIGRFAM NiFe hydrogenase maturation protein HypF - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF CMS1_k127_3687356_3 35754.JNYJ01000042_gene1380 2.394e-23 105.0 COG0298@1|root,COG0298@2|Bacteria,2IMSQ@201174|Actinobacteria,4DKQG@85008|Micromonosporales 201174|Actinobacteria O HupF/HypC family - - - ko:K04653 - - - - ko00000 - - - HupF_HypC CMS1_k127_3687356_1 1206744.BAGL01000128_gene6782 2.045e-161 516.0 COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4FVKR@85025|Nocardiaceae 201174|Actinobacteria O Hydrogenase formation hypA family hypD - - ko:K04654 - - - - ko00000 - - - HypD CMS1_k127_3687356_2 1121033.AUCF01000001_gene2413 2.577e-65 233.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2TQSJ@28211|Alphaproteobacteria,2JPTY@204441|Rhodospirillales 204441|Rhodospirillales O hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C CMS1_k127_3704719_2 379066.GAU_3734 4.174e-105 353.0 COG1807@1|root,COG1807@2|Bacteria,1ZUFB@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 CMS1_k127_3704719_1 1379270.AUXF01000002_gene1589 2.38e-120 395.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3704719_0 1379270.AUXF01000002_gene1585 4.863e-160 535.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_3719442_1 1379270.AUXF01000002_gene1585 1.053e-101 347.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_3719442_4 1379270.AUXF01000002_gene1589 7.044e-08 56.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3719442_0 1303518.CCALI_00626 4.582e-204 670.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 CMS1_k127_3719442_3 215803.DB30_2328 8.641e-09 62.0 2B7BE@1|root,320EI@2|Bacteria,1QAJB@1224|Proteobacteria,4354Q@68525|delta/epsilon subdivisions,2WZFR@28221|Deltaproteobacteria,2Z21J@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_3719442_2 1379270.AUXF01000002_gene1600 9.469e-85 303.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3727655_1 1278073.MYSTI_02540 8.454e-45 179.0 COG4188@1|root,COG4188@2|Bacteria,1N436@1224|Proteobacteria,439PH@68525|delta/epsilon subdivisions,2X512@28221|Deltaproteobacteria,2YZYR@29|Myxococcales 28221|Deltaproteobacteria S Platelet-activating factor acetylhydrolase, isoform II - - - - - - - - - - - - PAF-AH_p_II CMS1_k127_3727655_0 1144275.COCOR_01591 7.736e-84 292.0 COG0457@1|root,COG2819@1|root,COG0457@2|Bacteria,COG2819@2|Bacteria,1R54Q@1224|Proteobacteria 1224|Proteobacteria S hydrolase of the alpha beta superfamily - - - ko:K07017 - - - - ko00000 - - - Esterase CMS1_k127_3731356_0 1237149.C900_05550 4.046e-207 656.0 COG1506@1|root,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia 976|Bacteroidetes EU Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 CMS1_k127_3739888_2 861299.J421_2042 1.852e-49 180.0 COG0308@1|root,COG0308@2|Bacteria,1ZU50@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 CMS1_k127_3739888_0 1304880.JAGB01000003_gene1279 3.384e-100 347.0 COG4826@1|root,COG4826@2|Bacteria,1UYKX@1239|Firmicutes,24B76@186801|Clostridia 186801|Clostridia O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Dockerin_1,Serpin CMS1_k127_3739888_1 864051.BurJ1DRAFT_2729 5.99e-66 232.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,1KM43@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR CMS1_k127_3739888_3 1274524.BSONL12_18979 4.133e-19 91.0 COG0346@1|root,COG0346@2|Bacteria,1VCGT@1239|Firmicutes,4HKDV@91061|Bacilli,1ZGXG@1386|Bacillus 91061|Bacilli E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase CMS1_k127_3741311_30 861299.J421_2356 1.052e-06 51.0 COG0480@1|root,COG0480@2|Bacteria,1ZTFA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU CMS1_k127_3741311_15 479434.Sthe_0138 2.082e-46 190.0 COG1404@1|root,COG1404@2|Bacteria,2G7HM@200795|Chloroflexi 200795|Chloroflexi O PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - ko:K14645,ko:K17734 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 CMS1_k127_3741311_23 471854.Dfer_0264 3.115e-22 109.0 COG4733@1|root,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes,47P6C@768503|Cytophagia 976|Bacteroidetes G PFAM Fibronectin type III domain - - - - - - - - - - - - fn3 CMS1_k127_3741311_6 861299.J421_1280 2.574e-105 376.0 COG0515@1|root,COG3629@1|root,COG0515@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 2|Bacteria T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS1_k127_3741311_26 1348663.KCH_61990 3.688e-13 78.0 COG3554@1|root,COG3554@2|Bacteria,2INM2@201174|Actinobacteria,2M5VS@2063|Kitasatospora 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_3741311_2 945713.IALB_3087 1.157e-135 441.0 COG1509@1|root,COG1509@2|Bacteria 2|Bacteria E lysine 2,3-aminomutase activity kamA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_14,LAM_C,Radical_SAM CMS1_k127_3741311_22 552811.Dehly_0997 1.494e-29 135.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - 2.3.1.82 ko:K18815 - - - - br01600,ko00000,ko01000,ko01504 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 CMS1_k127_3741311_14 1254432.SCE1572_16985 8.327e-49 197.0 COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,2Z0D8@29|Myxococcales 28221|Deltaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C CMS1_k127_3741311_10 1191523.MROS_1829 6.882e-91 312.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlA - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C CMS1_k127_3741311_18 1269813.ATUL01000027_gene2638 4.769e-43 175.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1WY75@135613|Chromatiales 135613|Chromatiales H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis - - 1.5.1.3 ko:K00287,ko:K18590 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 br01600,ko00000,ko00001,ko00002,ko01000,ko01504 - - - DHFR_1 CMS1_k127_3741311_3 292415.Tbd_2040 3.057e-130 446.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,1KRFY@119069|Hydrogenophilales 119069|Hydrogenophilales F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt CMS1_k127_3741311_5 861299.J421_2362 4.367e-113 394.0 COG0277@1|root,COG0277@2|Bacteria,1ZTB7@142182|Gemmatimonadetes 142182|Gemmatimonadetes C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 CMS1_k127_3741311_12 861299.J421_2363 3.033e-62 231.0 COG1562@1|root,COG1562@2|Bacteria,1ZT7M@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Squalene/phytoene synthase - - 2.5.1.21 ko:K00801 ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130 - R00702,R02872,R06223 RC00362,RC00796,RC02839 ko00000,ko00001,ko01000,ko01006 - - - SQS_PSY CMS1_k127_3741311_7 671143.DAMO_2551 3.863e-104 361.0 COG1250@1|root,COG1250@2|Bacteria,2NP11@2323|unclassified Bacteria 2|Bacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N CMS1_k127_3741311_20 861299.J421_2367 4.438e-32 137.0 2FK9E@1|root,34BX2@2|Bacteria,1ZTYM@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_3741311_11 880073.Calab_1132 1.064e-78 297.0 COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria 2|Bacteria O prohibitin homologues hflC - - - - - - - - - - - Band_7 CMS1_k127_3741311_1 391625.PPSIR1_32759 2.902e-140 457.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2Z30V@29|Myxococcales 28221|Deltaproteobacteria I Thiolase, C-terminal domain - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K07508 ko00062,ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00062,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00085,M00087,M00088,M00095,M00373,M00374,M00375 R00238,R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747 RC00004,RC00326,RC00405,RC01702 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_3741311_8 378806.STAUR_4874 2.299e-96 336.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2YZ2Q@29|Myxococcales 28221|Deltaproteobacteria C Dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS1_k127_3741311_25 861299.J421_2370 6.019e-20 100.0 2F95J@1|root,341H1@2|Bacteria,1ZTZZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_3741311_24 1288484.APCS01000044_gene48 5.797e-21 107.0 COG2131@1|root,COG2131@2|Bacteria 2|Bacteria F dCMP deaminase activity comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 CMS1_k127_3741311_13 861299.J421_2372 1.509e-52 198.0 COG0328@1|root,COG0328@2|Bacteria,1ZTI8@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H CMS1_k127_3741311_9 2074.JNYD01000022_gene1521 1.288e-92 314.0 COG0709@1|root,COG0709@2|Bacteria,2GNP4@201174|Actinobacteria,4DYK1@85010|Pseudonocardiales 201174|Actinobacteria E Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C CMS1_k127_3741311_19 1449076.JOOE01000004_gene117 1.318e-42 161.0 COG0604@1|root,COG0604@2|Bacteria,1QY0U@1224|Proteobacteria 1224|Proteobacteria C Putative lumazine-binding - - - - - - - - - - - - Lumazine_bd_2 CMS1_k127_3741311_16 1237500.ANBA01000011_gene3370 4.382e-46 184.0 COG1228@1|root,COG1228@2|Bacteria,2I98N@201174|Actinobacteria 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 CMS1_k127_3741311_21 338966.Ppro_3323 1.478e-29 137.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,43UDK@69541|Desulfuromonadales 28221|Deltaproteobacteria U Involved in the TonB-independent uptake of proteins tolB GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N CMS1_k127_3741311_4 861299.J421_2390 7.888e-120 394.0 COG0604@1|root,COG0604@2|Bacteria,1ZT6R@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N CMS1_k127_3741311_0 1121920.AUAU01000027_gene1480 2.621e-168 563.0 COG0457@1|root,COG0457@2|Bacteria 1121920.AUAU01000027_gene1480|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_3741311_29 1121440.AUMA01000003_gene3041 1.064e-07 66.0 COG0457@1|root,COG0457@2|Bacteria,1R900@1224|Proteobacteria,42PXF@68525|delta/epsilon subdivisions,2WKEF@28221|Deltaproteobacteria,2MAQ2@213115|Desulfovibrionales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 CMS1_k127_3741311_28 861299.J421_4365 4.933e-10 71.0 2EY2H@1|root,33RBE@2|Bacteria,1ZTHK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_3741311_27 1379270.AUXF01000002_gene1389 3.516e-10 72.0 2EY2H@1|root,33RBE@2|Bacteria,1ZTHK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_3741311_17 1121272.KB903253_gene6866 5.796e-45 168.0 COG3832@1|root,COG3832@2|Bacteria,2IG6F@201174|Actinobacteria,4DDVZ@85008|Micromonosporales 201174|Actinobacteria S PFAM Activator of Hsp90 ATPase 1 family protein - - - - - - - - - - - - AHSA1 CMS1_k127_3758626_19 1379270.AUXF01000001_gene2408 3.908e-58 211.0 COG1680@1|root,COG1680@2|Bacteria,1ZTCC@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_3758626_31 1278073.MYSTI_07489 5.262e-08 64.0 COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria,42S3P@68525|delta/epsilon subdivisions,2WNCE@28221|Deltaproteobacteria,2YUQB@29|Myxococcales 28221|Deltaproteobacteria S Lipase maturation factor - - - - - - - - - - - - DUF393,LMF1 CMS1_k127_3758626_24 1379270.AUXF01000001_gene2407 6.113e-33 145.0 COG2151@1|root,COG2151@2|Bacteria,1ZTUD@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulfur cluster assembly protein - - - - - - - - - - - - FeS_assembly_P CMS1_k127_3758626_9 1379270.AUXF01000001_gene2405 6.552e-98 332.0 COG0349@1|root,COG0349@2|Bacteria,1ZSPS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J 3'-5' exonuclease - - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC CMS1_k127_3758626_27 861299.J421_2107 1.857e-17 95.0 COG0824@1|root,COG0824@2|Bacteria 2|Bacteria IQ Thioesterase ysmA - - ko:K07107,ko:K12500 - - - - ko00000,ko01000,ko01004 - - - 4HBT,4HBT_2 CMS1_k127_3758626_16 1379270.AUXF01000001_gene2403 2.605e-64 237.0 COG0596@1|root,COG0596@2|Bacteria,1ZU90@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Ndr family - - - - - - - - - - - - Abhydrolase_1 CMS1_k127_3758626_26 379066.GAU_2220 2.571e-28 117.0 2EQTX@1|root,33IDK@2|Bacteria,1ZUY7@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_3758626_21 1123393.KB891316_gene1352 8.781e-47 186.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,1KSPA@119069|Hydrogenophilales 119069|Hydrogenophilales O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Pro_isomerase CMS1_k127_3758626_20 861299.J421_4451 2.448e-57 213.0 COG0590@1|root,COG0590@2|Bacteria 2|Bacteria FJ tRNA wobble adenosine to inosine editing guaD - - - - - - - - - - - dCMP_cyt_deam_1 CMS1_k127_3758626_18 584708.Apau_0820 6.991e-59 209.0 COG1670@1|root,COG1670@2|Bacteria,3TCIV@508458|Synergistetes 508458|Synergistetes J Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_3 CMS1_k127_3758626_15 146922.JOFU01000037_gene3466 1.495e-65 237.0 COG4447@1|root,COG4447@2|Bacteria,2GMJN@201174|Actinobacteria 201174|Actinobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - PSII_BNR CMS1_k127_3758626_23 1122137.AQXF01000004_gene1404 4.763e-40 154.0 COG4430@1|root,COG4430@2|Bacteria,1QZAG@1224|Proteobacteria,2TZCK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - - CMS1_k127_3758626_8 1122137.AQXF01000005_gene1070 7.839e-101 339.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2TU6T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III - - - - - - - - - - - - Lactamase_B_2 CMS1_k127_3758626_17 861299.J421_0690 2.906e-63 223.0 2AYX9@1|root,31R2Z@2|Bacteria,1ZTNZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_3758626_1 330214.NIDE0577 2.462e-266 847.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - - - - - - - - - - DUF853,DUF87 CMS1_k127_3758626_32 1096546.WYO_2991 0.0002447 49.0 COG5504@1|root,COG5504@2|Bacteria,1RG9M@1224|Proteobacteria,2UDBF@28211|Alphaproteobacteria,1JWKJ@119045|Methylobacteriaceae 28211|Alphaproteobacteria O Predicted Zn-dependent protease (DUF2268) - - - - - - - - - - - - DUF2268 CMS1_k127_3758626_28 861299.J421_4052 2.618e-12 78.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_4052|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3758626_3 760192.Halhy_1321 1.194e-245 796.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1IVS2@117747|Sphingobacteriia 976|Bacteroidetes EU Dienelactone hydrolase family - - - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_3758626_7 234267.Acid_3470 1.248e-123 425.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_3758626_30 861299.J421_3690 1.463e-11 78.0 COG5492@1|root,COG5492@2|Bacteria,1ZT2D@142182|Gemmatimonadetes 142182|Gemmatimonadetes N domain, Protein - - - - - - - - - - - - - CMS1_k127_3758626_2 1122137.AQXF01000007_gene3573 3.896e-250 790.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N CMS1_k127_3758626_6 1238182.C882_1233 6.112e-134 439.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,2JQNM@204441|Rhodospirillales 204441|Rhodospirillales C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_C CMS1_k127_3758626_4 1049564.TevJSym_bb00050 1.313e-224 713.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N CMS1_k127_3758626_11 1049564.TevJSym_bb00040 6.458e-91 333.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C CMS1_k127_3758626_12 1249627.D779_4188 2.519e-89 317.0 COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales 135613|Chromatiales C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 CMS1_k127_3758626_0 1379270.AUXF01000001_gene2161 0.0 1934.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C CMS1_k127_3758626_5 1049564.TevJSym_aq00710 7.725e-137 449.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,RnfC_N,SLBB CMS1_k127_3758626_10 1239962.C943_00086 9.27e-96 342.0 COG4658@1|root,COG4658@2|Bacteria,4NESE@976|Bacteroidetes,47XQE@768503|Cytophagia 976|Bacteroidetes U Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE CMS1_k127_3758626_25 1049564.TevJSym_aq00690 6.841e-31 140.0 COG4659@1|root,COG4659@2|Bacteria,1REZV@1224|Proteobacteria,1T054@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport - - - - - - - - - - - - FMN_bind CMS1_k127_3758626_14 1049564.TevJSym_aq00680 3.086e-67 246.0 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1JBVX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfE2 - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr CMS1_k127_3758626_13 1049564.TevJSym_aq00670 2.241e-75 258.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1J4WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr CMS1_k127_3758626_22 1499967.BAYZ01000102_gene3563 7.868e-41 167.0 COG1477@1|root,COG1477@2|Bacteria,2NPJE@2323|unclassified Bacteria 2|Bacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein nosX - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE CMS1_k127_3762254_0 861299.J421_0795 1.329e-156 505.0 COG0156@1|root,COG0156@2|Bacteria,1ZST6@142182|Gemmatimonadetes 2|Bacteria H Beta-eliminating lyase bioF GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_3762254_1 1297742.A176_03127 7.532e-99 345.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales 28221|Deltaproteobacteria K acetyltransferase - - - - - - - - - - - - - CMS1_k127_3762254_2 290317.Cpha266_2305 5.007e-49 199.0 COG0451@1|root,COG0451@2|Bacteria,1FDUB@1090|Chlorobi 1090|Chlorobi M 3-beta hydroxysteroid dehydrogenase isomerase - - - - - - - - - - - - Epimerase CMS1_k127_3762254_3 861299.J421_0797 2.342e-30 138.0 COG0671@1|root,COG0671@2|Bacteria 2|Bacteria I phosphatidate phosphatase activity dgkA - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K00901,ko:K01096,ko:K19302 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02029,R02240,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_2369 DAGK_prokar,PAP2,PAP2_3 CMS1_k127_3762254_4 379066.GAU_0141 2.192e-18 91.0 COG3794@1|root,COG3794@2|Bacteria,1ZTTE@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Copper binding proteins, plastocyanin/azurin family - - - ko:K02638 ko00195,map00195 - - - ko00000,ko00001,ko00194 - - - Copper-bind CMS1_k127_3779054_0 1379270.AUXF01000002_gene1600 4.854e-71 266.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3779054_1 416591.Tlet_1253 1.555e-36 155.0 COG0793@1|root,COG0793@2|Bacteria,2GDPT@200918|Thermotogae 200918|Thermotogae M PFAM peptidase - - - - - - - - - - - - Peptidase_S41 CMS1_k127_3808065_0 945713.IALB_1643 1.552e-56 209.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - CMS1_k127_3808065_1 880073.Calab_0923 4.183e-11 74.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family ebh - - - - - - - - - - - DUF1611,Inhibitor_I9,Peptidase_S8,SLH CMS1_k127_3835823_4 1333856.L686_02855 3.068e-06 51.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1Z2DW@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC CMS1_k127_3835823_2 1229780.BN381_80207 1.045e-45 177.0 COG3336@1|root,COG3336@2|Bacteria 2|Bacteria G cytochrome c oxidase ctaG - - ko:K02351,ko:K02862 - - - - ko00000 - - - Caa3_CtaG CMS1_k127_3835823_0 1191523.MROS_1496 1.159e-188 614.0 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_3835823_1 1191523.MROS_1497 5.484e-126 420.0 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_3835823_3 880073.Calab_0802 5.406e-17 82.0 COG0591@1|root,COG0591@2|Bacteria,2NPAX@2323|unclassified Bacteria 2|Bacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF CMS1_k127_383727_3 903818.KI912268_gene1425 1.81e-49 183.0 COG4191@1|root,COG4191@2|Bacteria,3Y2IQ@57723|Acidobacteria 57723|Acidobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg CMS1_k127_383727_2 861299.J421_3620 7.87e-88 305.0 COG0745@1|root,COG0745@2|Bacteria,1ZT8B@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C CMS1_k127_383727_1 379066.GAU_2012 1.037e-96 334.0 COG5002@1|root,COG5002@2|Bacteria,1ZTF2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA CMS1_k127_383727_5 379066.GAU_2011 1.565e-30 130.0 COG0810@1|root,COG0810@2|Bacteria,1ZSVC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C CMS1_k127_383727_0 861299.J421_3617 3.573e-97 323.0 COG0811@1|root,COG0811@2|Bacteria,1ZTH1@142182|Gemmatimonadetes 142182|Gemmatimonadetes U MotA/TolQ/ExbB proton channel family - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB CMS1_k127_383727_4 861299.J421_3616 1.655e-31 128.0 COG0848@1|root,COG0848@2|Bacteria,1ZTTP@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD CMS1_k127_383727_6 861299.J421_3615 6.715e-28 117.0 COG0848@1|root,COG0848@2|Bacteria,1ZTXP@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD CMS1_k127_3870426_11 1379270.AUXF01000004_gene3027 1.133e-24 110.0 COG0092@1|root,COG0092@2|Bacteria,1ZTFT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C CMS1_k127_3870426_10 1379270.AUXF01000004_gene3028 1.284e-33 136.0 COG0091@1|root,COG0091@2|Bacteria,1ZTVF@142182|Gemmatimonadetes 142182|Gemmatimonadetes J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 CMS1_k127_3870426_9 1191523.MROS_0212 2.224e-38 145.0 COG0185@1|root,COG0185@2|Bacteria 2|Bacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 CMS1_k127_3870426_3 1379270.AUXF01000004_gene3030 1.317e-119 391.0 COG0090@1|root,COG0090@2|Bacteria,1ZSUP@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C CMS1_k127_3870426_12 861299.J421_2776 9.752e-24 108.0 COG0089@1|root,COG0089@2|Bacteria,1ZTWN@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 CMS1_k127_3870426_7 1379270.AUXF01000004_gene3032 6.013e-57 208.0 COG0088@1|root,COG0088@2|Bacteria,1ZSSW@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 CMS1_k127_3870426_5 1379270.AUXF01000004_gene3033 6.333e-66 237.0 COG0087@1|root,COG0087@2|Bacteria,1ZSW4@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 CMS1_k127_3870426_8 861299.J421_2773 8.892e-49 177.0 COG0051@1|root,COG0051@2|Bacteria,1ZTS9@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 CMS1_k127_3870426_2 379066.GAU_0871 1.855e-224 699.0 COG0050@1|root,COG0050@2|Bacteria,1ZSZD@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 CMS1_k127_3870426_1 640510.BC1001_2823 1.124e-284 892.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VJD5@28216|Betaproteobacteria,1K214@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 CMS1_k127_3870426_4 379066.GAU_0860 6.54e-72 248.0 COG0049@1|root,COG0049@2|Bacteria,1ZSQZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 CMS1_k127_3870426_6 1279038.KB907362_gene55 2.753e-64 221.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,2JS50@204441|Rhodospirillales 204441|Rhodospirillales J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 CMS1_k127_3870426_0 861299.J421_2768 0.0 1209.0 COG0086@1|root,COG0086@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 CMS1_k127_3880815_2 556269.ACDQ01000006_gene1601 1.058e-11 76.0 COG3728@1|root,COG3728@2|Bacteria,1NEAA@1224|Proteobacteria,2WFUB@28216|Betaproteobacteria 28216|Betaproteobacteria L Terminase small subunit - - - ko:K07474 - - - - ko00000 - - - Terminase_2 CMS1_k127_3880815_0 1278073.MYSTI_04090 4.328e-35 148.0 COG3568@1|root,COG3568@2|Bacteria,1N29G@1224|Proteobacteria,438Z7@68525|delta/epsilon subdivisions,2X8PT@28221|Deltaproteobacteria,2YY8K@29|Myxococcales 28221|Deltaproteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos CMS1_k127_3880815_1 1279038.KB907345_gene3428 5.434e-33 147.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2TRAF@28211|Alphaproteobacteria,2JV2B@204441|Rhodospirillales 204441|Rhodospirillales T diguanylate cyclase - - - - - - - - - - - - GGDEF CMS1_k127_3886159_0 404589.Anae109_1755 2.121e-121 406.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,43C89@68525|delta/epsilon subdivisions,2X7IN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 CMS1_k127_3886159_1 33876.JNXY01000028_gene3354 1.18e-11 78.0 COG0491@1|root,COG0491@2|Bacteria,2GMHY@201174|Actinobacteria,4DD4F@85008|Micromonosporales 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B CMS1_k127_3919060_17 861299.J421_3007 3.896e-25 110.0 2EQ8R@1|root,33HV0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_3919060_16 861299.J421_3006 4.783e-28 130.0 2E5IJ@1|root,3309Y@2|Bacteria,1ZTU3@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_3919060_5 1121472.AQWN01000008_gene1991 2.885e-168 541.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,2609R@186807|Peptococcaceae 186801|Clostridia E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT CMS1_k127_3919060_8 273068.TTE2202 1.723e-120 400.0 COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,24ETR@186801|Clostridia,42FP9@68295|Thermoanaerobacterales 186801|Clostridia C Belongs to the Glu Leu Phe Val dehydrogenases family ldh - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_3919060_9 861299.J421_3002 1.753e-118 395.0 COG1250@1|root,COG1250@2|Bacteria,1ZSRN@142182|Gemmatimonadetes 142182|Gemmatimonadetes I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N CMS1_k127_3919060_19 861299.J421_3001 3.442e-22 111.0 COG1266@1|root,COG1266@2|Bacteria,1ZTXV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS1_k127_3919060_18 926566.Terro_1522 2.438e-22 112.0 COG1268@1|root,COG1268@2|Bacteria,3Y5K4@57723|Acidobacteria,2JJWF@204432|Acidobacteriia 204432|Acidobacteriia S BioY family - - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY CMS1_k127_3919060_4 861299.J421_3000 4.234e-178 566.0 COG0183@1|root,COG0183@2|Bacteria,1ZTGX@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_3919060_2 234267.Acid_7295 3.776e-202 649.0 COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria 57723|Acidobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD CMS1_k127_3919060_1 861299.J421_2994 1.774e-302 957.0 COG0525@1|root,COG0525@2|Bacteria,1ZSXQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 CMS1_k127_3919060_15 1379270.AUXF01000005_gene588 9.801e-41 175.0 COG2372@1|root,COG2372@2|Bacteria,1ZTUI@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bacterial Ig-like domain - - - - - - - - - - - - Big_5 CMS1_k127_3919060_10 644966.Tmar_1144 6.095e-108 368.0 COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,3WCCS@538999|Clostridiales incertae sedis 186801|Clostridia J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA - 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA CMS1_k127_3919060_14 861299.J421_2990 3.656e-58 209.0 COG0299@1|root,COG0299@2|Bacteria,1ZTKJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N CMS1_k127_3919060_3 861299.J421_2989 5.681e-192 616.0 COG0138@1|root,COG0138@2|Bacteria,1ZT6N@142182|Gemmatimonadetes 142182|Gemmatimonadetes F AICARFT/IMPCHase bienzyme purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS CMS1_k127_3919060_7 861299.J421_2988 1.829e-160 532.0 COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_3919060_11 861299.J421_4260 1.271e-103 362.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS1_k127_3919060_13 452637.Oter_1107 2.942e-60 220.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,46V45@74201|Verrucomicrobia 74201|Verrucomicrobia K helix_turn_helix, mercury resistance - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 CMS1_k127_3919060_12 1499967.BAYZ01000119_gene3214 5.393e-88 302.0 COG2129@1|root,COG2129@2|Bacteria 2|Bacteria L metallophosphoesterase - - - ko:K07096 - - - - ko00000 - - - Metallophos,Metallophos_2,Metallophos_3 CMS1_k127_3919060_0 1191523.MROS_2798 0.0 1107.0 COG0574@1|root,COG0574@2|Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_2,PPDK_N,Response_reg CMS1_k127_3919060_6 1499967.BAYZ01000119_gene3216 5.322e-166 536.0 COG0574@1|root,COG0574@2|Bacteria,2NQHP@2323|unclassified Bacteria 2|Bacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_2,PPDK_N,Response_reg CMS1_k127_3923761_5 861299.J421_0469 6.874e-08 60.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_0469|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_3923761_2 861299.J421_1385 2.572e-41 168.0 COG2062@1|root,COG2062@2|Bacteria,1ZU0U@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 CMS1_k127_3923761_1 1303518.CCALI_01646 1.039e-59 213.0 COG1040@1|root,COG1040@2|Bacteria 2|Bacteria K competence protein ComFC - - - - - - - - - - - DZR,Pribosyltran,zinc_ribbon_2 CMS1_k127_3923761_4 351160.RCIX1302 6.107e-14 85.0 arCOG12580@1|root,arCOG12580@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3923761_0 861299.J421_4436 3.886e-215 681.0 COG2866@1|root,COG2866@2|Bacteria,1ZSMP@142182|Gemmatimonadetes 2|Bacteria E Zinc carboxypeptidase - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS1_k127_3938397_10 760568.Desku_1074 2.547e-118 385.0 COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia,25ZZD@186807|Peptococcaceae 186801|Clostridia C reductase alpha subunit - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS1_k127_3938397_22 335543.Sfum_1055 7.369e-22 100.0 COG0500@1|root,COG2226@2|Bacteria,1NHMR@1224|Proteobacteria,42XMB@68525|delta/epsilon subdivisions,2WT6Q@28221|Deltaproteobacteria,2MSC2@213462|Syntrophobacterales 28221|Deltaproteobacteria Q Ogr/Delta-like zinc finger - - - - - - - - - - - - Ogr_Delta CMS1_k127_3938397_14 706587.Desti_3831 1.953e-65 233.0 COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,42NM0@68525|delta/epsilon subdivisions,2WM96@28221|Deltaproteobacteria,2MRJH@213462|Syntrophobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC CMS1_k127_3938397_7 693661.Arcve_0424 2.102e-144 474.0 COG1148@1|root,arCOG02234@2157|Archaea,2Y7JF@28890|Euryarchaeota,247HS@183980|Archaeoglobi 183980|Archaeoglobi C heterodisulfide reductase subunit A - - - ko:K16885 - - - - ko00000 - - - FAD_oxidored,Fer4,Pyr_redox_2 CMS1_k127_3938397_0 387631.Asulf_02109 4.19e-281 882.0 COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi 183980|Archaeoglobi C Heterodisulfide reductase subunit A and related polyferredoxins - - - ko:K16886 - - - - ko00000 - - - Fer4,FlpD,Pyr_redox_2 CMS1_k127_3938397_12 177439.DP1108 9.682e-79 280.0 COG1150@1|root,COG2181@1|root,COG1150@2|Bacteria,COG2181@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain qmoC - - ko:K16887 - - - - ko00000 - - - Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam CMS1_k127_3938397_2 340177.Cag_1587 1.604e-188 596.0 COG2046@1|root,COG2046@2|Bacteria,1FF05@1090|Chlorobi 1090|Chlorobi F sulfate assimilation sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 CMS1_k127_3938397_21 314345.SPV1_03163 4.307e-23 110.0 COG1765@1|root,COG1765@2|Bacteria 2|Bacteria O OsmC-like protein ycaO - - ko:K09136 - - - - ko00000,ko03009 - - - OsmC,YcaO CMS1_k127_3938397_15 264732.Moth_1632 7.649e-49 176.0 COG2920@1|root,COG2920@2|Bacteria,1V6WF@1239|Firmicutes,24JRH@186801|Clostridia,42GKQ@68295|Thermoanaerobacterales 186801|Clostridia P TIGRFAM sulfur relay protein, TusE DsrC DsvC family - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC CMS1_k127_3938397_20 768704.Desmer_1640 2.11e-23 106.0 2CDHP@1|root,32RXU@2|Bacteria,1VQ7W@1239|Firmicutes,251NF@186801|Clostridia,265N8@186807|Peptococcaceae 186801|Clostridia S RsbT co-antagonist protein rsbRD N-terminal domain - - - - - - - - - - - - RsbRD_N CMS1_k127_3938397_11 706587.Desti_2673 5.527e-103 353.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria,2MREY@213462|Syntrophobacterales 28221|Deltaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Nitrate_red_gam CMS1_k127_3938397_1 706587.Desti_2672 2.033e-265 844.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria,2MQT6@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_8 CMS1_k127_3938397_17 706587.Desti_2671 3.922e-31 127.0 arCOG10385@1|root,32SEM@2|Bacteria,1N1IG@1224|Proteobacteria,42TMW@68525|delta/epsilon subdivisions,2WQBW@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - dsrJ - - - - - - - - - - - - CMS1_k127_3938397_13 264732.Moth_1604 4.135e-74 258.0 COG0437@1|root,COG0437@2|Bacteria,1UZKF@1239|Firmicutes,24EM4@186801|Clostridia 186801|Clostridia C TIGRFAM Tat (twin-arginine translocation) pathway signal sequence hmeA - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11 CMS1_k127_3938397_8 756499.Desde_0274 3.442e-144 472.0 COG5557@1|root,COG5557@2|Bacteria,1UYGM@1239|Firmicutes,24EQA@186801|Clostridia,263KI@186807|Peptococcaceae 186801|Clostridia C PFAM Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD CMS1_k127_3938397_3 696369.KI912183_gene2142 2.514e-175 558.0 COG2221@1|root,COG2221@2|Bacteria,1TRP0@1239|Firmicutes,24A5T@186801|Clostridia,260BJ@186807|Peptococcaceae 186801|Clostridia C PFAM nitrite and sulphite reductase 4Fe-4S dsrA - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr CMS1_k127_3938397_5 1121428.DESHY_30086___1 3.01e-154 496.0 COG2221@1|root,COG2221@2|Bacteria,1TZD2@1239|Firmicutes,24DEF@186801|Clostridia,2610K@186807|Peptococcaceae 186801|Clostridia C TIGRFAM sulfite reductase, dissimilatory-type beta subunit dsrB - 1.8.99.5 ko:K11181 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - Fer4,NIR_SIR,NIR_SIR_ferr CMS1_k127_3938397_4 331678.Cphamn1_1855 3.264e-168 546.0 COG0493@1|root,COG0493@2|Bacteria,1FDFY@1090|Chlorobi 1090|Chlorobi C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2 CMS1_k127_3938397_6 880072.Desac_1620 4.525e-146 479.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MQYU@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 CMS1_k127_3938397_18 1121403.AUCV01000010_gene1351 6.904e-30 134.0 COG1102@1|root,COG1102@2|Bacteria,1R82J@1224|Proteobacteria,42M5Z@68525|delta/epsilon subdivisions,2WMEJ@28221|Deltaproteobacteria,2MI55@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 CMS1_k127_3938397_16 1304885.AUEY01000026_gene3554 1.865e-32 136.0 COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2WJS2@28221|Deltaproteobacteria,2MPW7@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 CMS1_k127_3938397_9 706587.Desti_4441 5.382e-124 424.0 COG0730@1|root,COG0730@2|Bacteria,1NJ47@1224|Proteobacteria,42P2D@68525|delta/epsilon subdivisions,2WMG7@28221|Deltaproteobacteria 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_3938397_19 706587.Desti_4440 1.314e-29 134.0 2DDIC@1|root,32U1K@2|Bacteria,1NDK2@1224|Proteobacteria,42VX8@68525|delta/epsilon subdivisions,2WSEV@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_3938397_24 42256.RradSPS_1758 1.154e-15 83.0 COG1648@1|root,COG1648@2|Bacteria,2GTES@201174|Actinobacteria,4CQK2@84995|Rubrobacteria 84995|Rubrobacteria H Sirohaem biosynthesis protein central - - 1.3.1.76,4.99.1.4 ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M CMS1_k127_3938397_25 1173264.KI913949_gene328 1.682e-06 59.0 COG0276@1|root,COG0276@2|Bacteria,1G1UI@1117|Cyanobacteria,1H74W@1150|Oscillatoriales 1117|Cyanobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Chloroa_b-bind,Ferrochelatase CMS1_k127_3942294_0 1121920.AUAU01000013_gene1695 6.521e-228 719.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,3Y2WK@57723|Acidobacteria 57723|Acidobacteria M Tricorn protease homolog - - - - - - - - - - - - PD40,Peptidase_S41,Tricorn_C1 CMS1_k127_3942294_1 290397.Adeh_0190 2.378e-78 274.0 COG1215@1|root,COG1215@2|Bacteria,1R988@1224|Proteobacteria,42QKI@68525|delta/epsilon subdivisions,2WM6J@28221|Deltaproteobacteria,2Z2XX@29|Myxococcales 28221|Deltaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_3942294_2 1499967.BAYZ01000043_gene2292 1.577e-42 165.0 2E2YR@1|root,32XZF@2|Bacteria 2|Bacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 CMS1_k127_3942294_3 1210884.HG799465_gene12236 1.76e-32 127.0 COG1506@1|root,COG1506@2|Bacteria,2IYRT@203682|Planctomycetes 203682|Planctomycetes E Dipeptidyl peptidase IV (DPP IV) - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 CMS1_k127_3948384_1 861299.J421_2628 6.967e-94 314.0 COG0224@1|root,COG0224@2|Bacteria,1ZSZR@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt CMS1_k127_3948384_0 861299.J421_2629 1.16e-244 762.0 COG0055@1|root,COG0055@2|Bacteria,1ZSNP@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N CMS1_k127_3948384_2 1379270.AUXF01000004_gene3171 8.144e-20 92.0 COG0355@1|root,COG0355@2|Bacteria,1ZU1K@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N CMS1_k127_3962721_2 1117319.PSPO_09889 7.382e-29 122.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,2Q3UZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria IQ Fungal family of unknown function (DUF1776) - - - - - - - - - - - - adh_short CMS1_k127_3962721_4 593907.Celgi_1162 4.23e-18 93.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase pac - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 CMS1_k127_3962721_5 82654.Pse7367_0370 1.219e-16 94.0 COG5640@1|root,COG5640@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - - - - - - - - - - - Trypsin,VPEP CMS1_k127_3962721_1 861299.J421_0148 2.248e-48 184.0 COG2207@1|root,COG2207@2|Bacteria,1ZV8Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 CMS1_k127_3962721_3 1384054.N790_01735 1.765e-26 116.0 COG0346@1|root,COG0346@2|Bacteria,1NB98@1224|Proteobacteria,1SS2K@1236|Gammaproteobacteria 1236|Gammaproteobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase CMS1_k127_3962721_0 420324.KI912080_gene8209 1.917e-50 181.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - - - - - - - - - - DJ-1_PfpI,HTH_18 CMS1_k127_3965420_0 379066.GAU_1316 5.378e-61 227.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity cebC - - - - - - - - - - - OEP CMS1_k127_3965420_1 379066.GAU_1315 3.7e-30 130.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cebB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23,HlyD_D4,YtkA CMS1_k127_4000518_4 1027273.GZ77_01420 2.613e-37 146.0 2DNW1@1|root,32ZFG@2|Bacteria,1NBSM@1224|Proteobacteria,1S8G5@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_4000518_2 743720.Psefu_0444 1.34e-45 172.0 COG2020@1|root,COG2020@2|Bacteria,1N3YJ@1224|Proteobacteria,1SGBM@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT CMS1_k127_4000518_0 314285.KT71_11209 1.93e-64 235.0 2DCFR@1|root,2ZDYQ@2|Bacteria,1RB5X@1224|Proteobacteria,1RN4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_4000518_1 1232437.KL662006_gene4384 1.981e-53 210.0 2E9PG@1|root,333VW@2|Bacteria,1NEU7@1224|Proteobacteria,42ZPQ@68525|delta/epsilon subdivisions,2WV1S@28221|Deltaproteobacteria,2MNDN@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_4000518_3 536227.CcarbDRAFT_1370 7.22e-40 163.0 COG1404@1|root,COG1404@2|Bacteria,1UFB1@1239|Firmicutes,24DCR@186801|Clostridia,36H0Y@31979|Clostridiaceae 186801|Clostridia O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8 CMS1_k127_4016696_1 1047013.AQSP01000079_gene2041 8.923e-51 196.0 COG0841@1|root,COG0841@2|Bacteria,2NQI6@2323|unclassified Bacteria 2|Bacteria V AcrB/AcrD/AcrF family mdtC - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran CMS1_k127_4016696_3 215803.DB30_2995 3.806e-15 89.0 COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,42SGU@68525|delta/epsilon subdivisions,2WPBP@28221|Deltaproteobacteria,2YVU1@29|Myxococcales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS1_k127_4016696_0 1047013.AQSP01000079_gene2044 1.792e-53 204.0 COG0845@1|root,COG0845@2|Bacteria,2NR3D@2323|unclassified Bacteria 2|Bacteria M Biotin-lipoyl like - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_4016696_2 1041159.AZUW01000019_gene56 1.398e-22 100.0 COG0640@1|root,COG0640@2|Bacteria,1RJ39@1224|Proteobacteria,2UA6C@28211|Alphaproteobacteria,4BKBT@82115|Rhizobiaceae 28211|Alphaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 CMS1_k127_4016696_4 316056.RPC_4620 1.16e-09 61.0 COG3832@1|root,COG3832@2|Bacteria,1RAW4@1224|Proteobacteria,2UI5Z@28211|Alphaproteobacteria,3JYIZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 CMS1_k127_4104427_3 1177154.Y5S_00556 2.496e-38 159.0 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,1T2MP@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_4104427_4 404380.Gbem_4004 3.495e-16 92.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran,OEP CMS1_k127_4104427_0 1125863.JAFN01000001_gene1462 0.0 1141.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS CMS1_k127_4104427_2 1049564.TevJSym_aq00680 8.016e-61 219.0 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1JBVX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfE2 - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr CMS1_k127_4104427_1 1049564.TevJSym_aq00670 1.115e-64 241.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1J4WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr CMS1_k127_4143440_0 234267.Acid_5004 1.197e-37 145.0 COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria 57723|Acidobacteria E Peptidase M14, carboxypeptidase A - - - - - - - - - - - - Peptidase_M14 CMS1_k127_4143440_1 861299.J421_1545 3.405e-18 95.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS1_k127_4143440_2 760117.JN27_22600 2.065e-07 57.0 2DVZY@1|root,33XWI@2|Bacteria 2|Bacteria S Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core CMS1_k127_4272619_0 338969.Rfer_3144 2.584e-60 228.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4272619_1 1265505.ATUG01000001_gene4392 1.667e-39 159.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria,2MNB4@213118|Desulfobacterales 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC CMS1_k127_4272619_3 62928.azo2959 1.865e-12 70.0 COG0599@1|root,COG0599@2|Bacteria,1P85X@1224|Proteobacteria,2W5YK@28216|Betaproteobacteria 28216|Betaproteobacteria S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD CMS1_k127_4272619_2 1484460.JSWG01000006_gene2967 1.406e-17 84.0 COG1266@1|root,COG1266@2|Bacteria,4NGBZ@976|Bacteroidetes,1HZ6J@117743|Flavobacteriia 976|Bacteroidetes S CAAX protease self-immunity - - - - - - - - - - - - Abi CMS1_k127_429248_0 340.xcc-b100_0467 2.953e-192 608.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1X3CQ@135614|Xanthomonadales 135614|Xanthomonadales E Transporter yhiP - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 CMS1_k127_429248_1 861299.J421_2986 5.778e-121 403.0 COG0008@1|root,COG0008@2|Bacteria,1ZSSX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c CMS1_k127_429248_2 1123229.AUBC01000001_gene1837 4.611e-45 179.0 2E61B@1|root,330QK@2|Bacteria,1N39M@1224|Proteobacteria,2U8C9@28211|Alphaproteobacteria,3JZ9V@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_429248_4 1267535.KB906767_gene289 3.682e-06 55.0 297M3@1|root,2ZUU3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_4315978_0 1123073.KB899245_gene47 9.36e-77 264.0 COG3315@1|root,COG3315@2|Bacteria,1RG18@1224|Proteobacteria,1TCTK@1236|Gammaproteobacteria,1X9S9@135614|Xanthomonadales 135614|Xanthomonadales Q Leucine carboxyl methyltransferase - - - - - - - - - - - - LCM CMS1_k127_4315978_1 395961.Cyan7425_3596 1.732e-60 227.0 COG2258@1|root,COG2258@2|Bacteria,1G4BR@1117|Cyanobacteria 1117|Cyanobacteria S MOSC domain - - - - - - - - - - - - 3-alpha,MOSC CMS1_k127_4367963_4 861299.J421_2930 7.012e-76 273.0 COG0673@1|root,COG0673@2|Bacteria,1ZSV9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Homoserine dehydrogenase, NAD binding domain - - - - - - - - - - - - GFO_IDH_MocA CMS1_k127_4367963_6 861299.J421_2928 1.447e-56 213.0 COG2385@1|root,COG2385@2|Bacteria,1ZT25@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID CMS1_k127_4367963_1 861299.J421_2927 4.391e-159 513.0 COG0621@1|root,COG0621@2|Bacteria,1ZT70@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,UPF0004 CMS1_k127_4367963_2 861299.J421_2922 8.597e-140 452.0 COG0568@1|root,COG0568@2|Bacteria,1ZSR6@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 CMS1_k127_4367963_0 1379270.AUXF01000005_gene479 4.125e-187 594.0 COG2204@1|root,COG2204@2|Bacteria,1ZT50@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_4367963_7 1128421.JAGA01000002_gene1053 2.788e-28 132.0 COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria 2|Bacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase CMS1_k127_4367963_5 861299.J421_2914 7.449e-60 237.0 COG1606@1|root,COG1606@2|Bacteria 2|Bacteria L tRNA processing - - - ko:K06864 - - - - ko00000 - - - Asn_synthase,NAD_synthase CMS1_k127_4367963_9 1191523.MROS_1521 1.756e-18 95.0 COG3271@1|root,COG3271@2|Bacteria 2|Bacteria - - - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - DUF3335,Peptidase_C39,Peptidase_C39_2,Peptidase_C70,TPR_16,TPR_19,TPR_2,TPR_8 CMS1_k127_4367963_11 379066.GAU_1167 2.934e-14 81.0 2FCTB@1|root,344W9@2|Bacteria,1ZU4K@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4367963_3 861299.J421_2962 6.117e-91 319.0 COG4191@1|root,COG4191@2|Bacteria,1ZUC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg CMS1_k127_4367963_8 395964.KE386496_gene158 5.634e-21 102.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3N9K2@45404|Beijerinckiaceae 28211|Alphaproteobacteria T PAS domain cckA - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg CMS1_k127_4367963_10 1485544.JQKP01000001_gene891 2.944e-16 79.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,44V3K@713636|Nitrosomonadales 28216|Betaproteobacteria O Magnesium chelatase, subunit ChlI C-terminal comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C CMS1_k127_4371308_1 861299.J421_5865 6.646e-29 120.0 COG1680@1|root,COG1680@2|Bacteria,1ZTCC@142182|Gemmatimonadetes 2|Bacteria V Beta-lactamase nagA - - - - - - - - - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C CMS1_k127_4371308_0 1112212.JH584235_gene2593 1.097e-37 159.0 COG2234@1|root,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,2VF5N@28211|Alphaproteobacteria,2KDVY@204457|Sphingomonadales 204457|Sphingomonadales V Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_44664_2 329726.AM1_0630 3.532e-09 65.0 COG1404@1|root,COG1404@2|Bacteria,1G1G8@1117|Cyanobacteria 1117|Cyanobacteria O Subtilisin-like serine protease - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 CMS1_k127_44664_0 379066.GAU_2847 5.937e-47 185.0 2ARQH@1|root,31H1J@2|Bacteria,1ZUJU@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Phosphodiester glycosidase - - - - - - - - - - - - NAGPA CMS1_k127_4491256_1 379066.GAU_0653 1.963e-101 335.0 COG0318@1|root,COG0318@2|Bacteria,1ZSXP@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C CMS1_k127_4491256_0 1379270.AUXF01000004_gene3227 2.637e-112 372.0 COG1432@1|root,COG1432@2|Bacteria,1ZSRW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH CMS1_k127_4502176_2 404589.Anae109_3628 4.292e-60 216.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria 1224|Proteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - - - - - - - - - - Oxidored_molyb CMS1_k127_4502176_1 861299.J421_0327 7.185e-63 224.0 COG4117@1|root,COG4117@2|Bacteria,1ZUUH@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB CMS1_k127_4502176_0 861299.J421_0450 3.506e-66 239.0 COG3437@1|root,COG3437@2|Bacteria,1ZTD3@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HD domain - - - - - - - - - - - - HD,Response_reg CMS1_k127_4502176_3 1499968.TCA2_3896 1.843e-07 61.0 COG2207@1|root,COG2207@2|Bacteria,1TQKE@1239|Firmicutes,4HAA2@91061|Bacilli,26SUB@186822|Paenibacillaceae 91061|Bacilli K Transcriptional regulator - - - ko:K13653 - - - - ko00000,ko03000 - - - HTH_18 CMS1_k127_4520915_12 644968.DFW101_3702 5.031e-19 94.0 COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2WN3F@28221|Deltaproteobacteria,2MAF8@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_4520915_10 861299.J421_0857 4.227e-24 115.0 COG3206@1|root,COG3206@2|Bacteria 2|Bacteria M extracellular polysaccharide biosynthetic process - - - ko:K16554,ko:K21473 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01002,ko01011,ko02000 8.A.3.1 - - GNVR,NLPC_P60,Peptidase_M23,Wzz CMS1_k127_4520915_2 861299.J421_3479 7.461e-158 525.0 COG1596@1|root,COG1596@2|Bacteria,1ZUC0@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Polysaccharide biosynthesis/export protein - - - - - - - - - - - - Poly_export,SLBB CMS1_k127_4520915_1 760568.Desku_1734 8.532e-179 569.0 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24G9G@186801|Clostridia,264B5@186807|Peptococcaceae 186801|Clostridia M Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 CMS1_k127_4520915_7 316274.Haur_4323 2.08e-78 287.0 COG0451@1|root,COG0451@2|Bacteria,2GBWQ@200795|Chloroflexi,3774S@32061|Chloroflexia 32061|Chloroflexia M PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase CMS1_k127_4520915_9 85643.Tmz1t_1126 4.724e-66 254.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,2KWA7@206389|Rhodocyclales 206389|Rhodocyclales M Bacterial sugar transferase - - - ko:K13012 - - - - ko00000,ko01005 - - - Bac_transf CMS1_k127_4520915_8 290397.Adeh_4294 1.7e-73 270.0 29SIY@1|root,30DQ4@2|Bacteria 2|Bacteria S Capsule assembly protein Wzi - - - - - - - - - - - - Caps_assemb_Wzi CMS1_k127_4520915_13 58123.JOFJ01000014_gene5177 7.5e-09 68.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding CMS1_k127_4520915_11 1267533.KB906734_gene3922 2.113e-23 114.0 2E0ZH@1|root,32WFR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - O_anti_polymase CMS1_k127_4520915_0 1121033.AUCF01000004_gene4701 1.242e-193 628.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales 204441|Rhodospirillales E COG0367 Asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS1_k127_4520915_4 760568.Desku_1745 5.422e-107 359.0 COG0438@1|root,COG0438@2|Bacteria,1V5W1@1239|Firmicutes,24HV6@186801|Clostridia,263ZC@186807|Peptococcaceae 186801|Clostridia M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 CMS1_k127_4520915_6 323261.Noc_2479 5.653e-98 346.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RRWX@1236|Gammaproteobacteria,1WYF9@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_4520915_3 357808.RoseRS_2395 1.527e-110 366.0 COG0451@1|root,COG0451@2|Bacteria,2G6ET@200795|Chloroflexi,375HU@32061|Chloroflexia 32061|Chloroflexia M short-chain dehydrogenase reductase SDR - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase CMS1_k127_4520915_5 546414.Deide_20310 2.65e-102 348.0 COG0367@1|root,COG0367@2|Bacteria,1WK3V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS1_k127_4521972_0 1191523.MROS_0969 2.426e-304 958.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N CMS1_k127_4521972_14 1382306.JNIM01000001_gene1210 1.961e-25 122.0 COG2267@1|root,COG2267@2|Bacteria,2GBHH@200795|Chloroflexi 200795|Chloroflexi I Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 CMS1_k127_4521972_6 314282.PCNPT3_07895 2.046e-144 482.0 COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS1_k127_4521972_2 1122137.AQXF01000001_gene3014 1.838e-270 860.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria 2|Bacteria G Belongs to the glycosyl hydrolase 13 family - - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,CBM_48 CMS1_k127_4521972_5 886377.Murru_0039 1.173e-193 619.0 COG0366@1|root,COG0366@2|Bacteria,4NGC8@976|Bacteroidetes,1HWR1@117743|Flavobacteriia 976|Bacteroidetes G Alpha-amylase domain - - 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase CMS1_k127_4521972_3 313596.RB2501_12662 5.216e-206 653.0 COG2211@1|root,COG2211@2|Bacteria,4NE3F@976|Bacteroidetes,1HWRM@117743|Flavobacteriia 976|Bacteroidetes G major facilitator - - - ko:K16211 - - - - ko00000,ko02000 2.A.2.6 - - MFS_1,MFS_2 CMS1_k127_4521972_4 861299.J421_4129 9.545e-198 634.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB CMS1_k127_4521972_1 861299.J421_4130 7.964e-283 903.0 COG1629@1|root,COG4771@2|Bacteria,1ZVAQ@142182|Gemmatimonadetes 2|Bacteria P TonB dependent receptor susC - - ko:K21573 - - - - ko00000,ko02000 1.B.14.6.1 - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS1_k127_4521972_15 999541.bgla_2g16270 2.405e-06 59.0 COG3258@1|root,COG3258@2|Bacteria,1QTYW@1224|Proteobacteria,2VIQV@28216|Betaproteobacteria,1K6FN@119060|Burkholderiaceae 28216|Betaproteobacteria C cytochrome - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrome_CBB3 CMS1_k127_4521972_8 251229.Chro_1585 8.261e-87 302.0 COG2041@1|root,COG2041@2|Bacteria,1GA09@1117|Cyanobacteria 1117|Cyanobacteria S Oxidoreductase molybdopterin binding - - - - - - - - - - - - Mo-co_dimer,Oxidored_molyb CMS1_k127_4521972_17 1366050.N234_00165 0.0006847 53.0 2DKFZ@1|root,309D6@2|Bacteria,1QZK6@1224|Proteobacteria,2WHMG@28216|Betaproteobacteria,1KINP@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4382) - - - - - - - - - - - - DUF4382 CMS1_k127_4521972_12 861299.J421_0662 2.375e-60 211.0 COG2030@1|root,COG2030@2|Bacteria 2|Bacteria I dehydratase - - - - - - - - - - - - MaoC_dehydratas CMS1_k127_4521972_7 518766.Rmar_1973 3.421e-93 315.0 COG1878@1|root,COG1878@2|Bacteria,4PIWM@976|Bacteroidetes,1FJPB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Putative cyclase - GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 ko:K07130 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Cyclase CMS1_k127_4521972_16 558152.IQ37_08665 0.000307 51.0 COG2825@1|root,COG2825@2|Bacteria,4NSCM@976|Bacteroidetes,1IJ5F@117743|Flavobacteriia,3ZRS1@59732|Chryseobacterium 976|Bacteroidetes M Outer membrane protein (OmpH-like) ompH - - ko:K06142 - - - - ko00000 - - - OmpH CMS1_k127_4521972_9 292459.STH2612 1.063e-74 270.0 COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,24DV3@186801|Clostridia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF4173 CMS1_k127_4521972_10 861299.J421_2099 1.692e-73 260.0 COG1285@1|root,COG1285@2|Bacteria,1ZUVP@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 CMS1_k127_4521972_11 1123278.KB893581_gene1029 2.646e-65 246.0 28M5H@1|root,2ZAJ9@2|Bacteria,4NESS@976|Bacteroidetes,47NNA@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_4521972_13 1317122.ATO12_02240 4.791e-59 222.0 COG0639@1|root,COG0666@1|root,COG0639@2|Bacteria,COG0666@2|Bacteria,4NIQ8@976|Bacteroidetes,1I0V8@117743|Flavobacteriia,2YIN4@290174|Aquimarina 976|Bacteroidetes T Protein phosphatase 2A homologues, catalytic domain. - - - - - - - - - - - - Ank_2,Metallophos CMS1_k127_4524970_3 309807.SRU_2821 4.984e-185 596.0 COG4805@1|root,COG4805@2|Bacteria,4NFAK@976|Bacteroidetes,1FKD5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 CMS1_k127_4524970_6 1379698.RBG1_1C00001G0516 5.568e-135 439.0 COG0473@1|root,COG0473@2|Bacteria,2NP1R@2323|unclassified Bacteria 2|Bacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS1_k127_4524970_11 391625.PPSIR1_09331 3.655e-56 225.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria 2|Bacteria I 3-hydroxyacyl-CoA dehydrogenase paaH GO:0003674,GO:0003824,GO:0003857,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0008691,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - iECO103_1326.ECO103_1532,iJN746.PP_3282 3HCDH,3HCDH_N CMS1_k127_4524970_9 768066.HELO_3947 3.623e-69 256.0 COG0183@1|root,COG0183@2|Bacteria,1MXYM@1224|Proteobacteria,1S0V9@1236|Gammaproteobacteria,1XN9H@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N CMS1_k127_4524970_23 745411.B3C1_04490 6.121e-05 55.0 2DPVN@1|root,32UMW@2|Bacteria,1N0TH@1224|Proteobacteria,1S98X@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Acyl-CoA cholesterol acyltransferase - - - - - - - - - - - - MBOAT CMS1_k127_4524970_8 393595.ABO_0204 3.516e-70 254.0 COG1305@1|root,COG1305@2|Bacteria,1MW3P@1224|Proteobacteria,1RSQ5@1236|Gammaproteobacteria,1XMKP@135619|Oceanospirillales 135619|Oceanospirillales E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core CMS1_k127_4524970_4 370438.PTH_2846 1.963e-175 569.0 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae 186801|Clostridia C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C CMS1_k127_4524970_14 498761.HM1_1467 8.082e-44 169.0 COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia 186801|Clostridia C indolepyruvate ferredoxin oxidoreductase beta subunit iorB - 1.2.7.8 ko:K00180 - - - - br01601,ko00000,ko01000 - - - POR CMS1_k127_4524970_21 269799.Gmet_1931 1.886e-23 107.0 COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,43UWZ@69541|Desulfuromonadales 28221|Deltaproteobacteria K transcriptional regulator, Rrf2 family - - - - - - - - - - - - Rrf2 CMS1_k127_4524970_12 616991.JPOO01000003_gene1702 9.306e-54 199.0 COG2010@1|root,COG2010@2|Bacteria,4P8QV@976|Bacteroidetes 976|Bacteroidetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C CMS1_k127_4524970_0 1121920.AUAU01000008_gene1619 0.0 1588.0 COG5013@1|root,COG5013@2|Bacteria 2|Bacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057 1.7.5.1 ko:K00370,ko:K17050 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - iSBO_1134.SBO_1842,iUMN146_1321.UM146_09685 Molybdopterin,Molydop_binding,Nitr_red_alph_N CMS1_k127_4524970_1 616991.JPOO01000003_gene1700 4.757e-243 760.0 COG1140@1|root,COG1140@2|Bacteria 2|Bacteria C nitrate reductase beta subunit narH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0033554,GO:0042126,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204,GO:2001057 1.7.5.1 ko:K00371 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - iAF987.Gmet_1021,iEcE24377_1341.EcE24377A_1376,iEcolC_1368.EcolC_2189 Fer4_11,Nitr_red_bet_C CMS1_k127_4524970_18 616991.JPOO01000003_gene1699 5.201e-27 123.0 COG2180@1|root,COG2180@2|Bacteria 2|Bacteria C chaperone-mediated protein complex assembly narJ GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - ko:K00373,ko:K17052 ko02020,map02020 - - - ko00000,ko00001,ko02000 5.A.3.8 - iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687 Nitrate_red_del CMS1_k127_4524970_10 616991.JPOO01000003_gene1698 2.716e-62 227.0 COG2181@1|root,COG2181@2|Bacteria 2|Bacteria C nitrate reductase activity narI GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 1.7.5.1 ko:K00370,ko:K00374,ko:K02575 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00615,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.1.8,5.A.3.1 - iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iNJ661.Rv1164,iSF_1195.SF1230,ic_1306.c1897 Nitrate_red_gam CMS1_k127_4524970_2 1048983.EL17_22770 8.504e-219 689.0 COG2223@1|root,COG2223@2|Bacteria,4NETE@976|Bacteroidetes,47MEV@768503|Cytophagia 976|Bacteroidetes P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 CMS1_k127_4524970_5 1232410.KI421415_gene2942 1.038e-171 562.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,42YV6@68525|delta/epsilon subdivisions,2WTK4@28221|Deltaproteobacteria,43SVX@69541|Desulfuromonadales 28221|Deltaproteobacteria P Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 CMS1_k127_4524970_7 1379270.AUXF01000002_gene1485 2.277e-74 265.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid blaB3 - - - - - - - - - - - Lactamase_B CMS1_k127_4524970_16 1089547.KB913013_gene1392 1.553e-36 145.0 COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes,47QGD@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1572) - - - - - - - - - - - - DUF1572 CMS1_k127_4524970_13 290317.Cpha266_1929 4.561e-50 185.0 COG0824@1|root,COG0824@2|Bacteria,1FFJS@1090|Chlorobi 1090|Chlorobi S Acyl-ACP thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - Acyl-ACP_TE CMS1_k127_4524970_17 290317.Cpha266_0598 9.511e-33 140.0 COG0758@1|root,COG0758@2|Bacteria,1FE5W@1090|Chlorobi 1090|Chlorobi LU Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier CMS1_k127_4524970_19 1267535.KB906767_gene4349 1.871e-25 120.0 COG1807@1|root,COG1807@2|Bacteria,3Y46U@57723|Acidobacteria 57723|Acidobacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 CMS1_k127_4524970_22 1040987.AZUY01000021_gene1601 3.23e-05 54.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRS5@28211|Alphaproteobacteria,43KWE@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C cytochrome c oxidase subunit II - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,Cytochrom_C CMS1_k127_4524970_20 234267.Acid_5134 7.668e-25 117.0 COG1595@1|root,COG1595@2|Bacteria,3Y7Q6@57723|Acidobacteria 57723|Acidobacteria K DNA-templated transcription, initiation - - - - - - - - - - - - - CMS1_k127_4524970_15 234267.Acid_4096 1.506e-38 152.0 COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria 57723|Acidobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4525980_1 1121920.AUAU01000004_gene686 5.223e-91 310.0 COG1131@1|root,COG1131@2|Bacteria,3Y3VU@57723|Acidobacteria 57723|Acidobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_4525980_0 450851.PHZ_p0155 4.4e-98 334.0 COG0842@1|root,COG0842@2|Bacteria,1QVX7@1224|Proteobacteria,2TX9C@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC-2 family transporter protein - - - ko:K01992,ko:K13926 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS1_k127_4525980_2 1384056.N787_01670 7.884e-84 306.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,1RQSE@1236|Gammaproteobacteria,1X7D8@135614|Xanthomonadales 135614|Xanthomonadales V ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_3 CMS1_k127_4525980_3 1121918.ARWE01000001_gene3297 9.526e-26 110.0 COG0644@1|root,COG0644@2|Bacteria,1R4JF@1224|Proteobacteria 1224|Proteobacteria C COG0644 Dehydrogenases (flavoproteins) - - - - - - - - - - - - HI0933_like,NAD_binding_8 CMS1_k127_4526675_0 266117.Rxyl_2676 1.895e-46 169.0 COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4CTQB@84995|Rubrobacteria 84995|Rubrobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD CMS1_k127_4526675_1 1242864.D187_008590 2.286e-25 118.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 CMS1_k127_4526675_2 1122239.AULS01000003_gene2516 2.003e-08 61.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FKZR@85023|Microbacteriaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain fadD2 - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C CMS1_k127_4526676_91 1379270.AUXF01000001_gene2766 1.122e-13 73.0 COG1225@1|root,COG1225@2|Bacteria,1ZUGC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Redoxin - - - - - - - - - - - - AhpC-TSA CMS1_k127_4526676_94 379066.GAU_2624 1.101e-09 64.0 COG1225@1|root,COG1225@2|Bacteria,1ZUGC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Redoxin - - - - - - - - - - - - AhpC-TSA CMS1_k127_4526676_37 1121875.KB907547_gene3048 5.532e-99 334.0 COG0596@1|root,COG0596@2|Bacteria,4NZUP@976|Bacteroidetes,1HZ6I@117743|Flavobacteriia 976|Bacteroidetes S Releases the N-terminal proline from various substrates - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 CMS1_k127_4526676_18 1379270.AUXF01000005_gene642 6.908e-151 507.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4526676_88 1056512.D515_00859 5.248e-15 88.0 COG1538@1|root,COG1538@2|Bacteria,1N23P@1224|Proteobacteria,1RMXN@1236|Gammaproteobacteria,1Y2U2@135623|Vibrionales 135623|Vibrionales MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS1_k127_4526676_92 1288298.rosmuc_02750 2.034e-13 83.0 COG0845@1|root,COG0845@2|Bacteria,1PVWV@1224|Proteobacteria,2TTJX@28211|Alphaproteobacteria,46RMI@74030|Roseovarius 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_4526676_7 880073.Calab_0505 4.108e-209 700.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran CMS1_k127_4526676_60 246197.MXAN_0062 8.852e-46 168.0 COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,42U1Z@68525|delta/epsilon subdivisions,2WQ05@28221|Deltaproteobacteria,2Z1RY@29|Myxococcales 28221|Deltaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 CMS1_k127_4526676_51 483219.LILAB_29130 2.944e-70 255.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42U6K@68525|delta/epsilon subdivisions,2WQ4K@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_D23 CMS1_k127_4526676_31 246197.MXAN_4201 4.516e-117 391.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWSR@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_4526676_97 621372.ACIH01000098_gene2740 1.217e-05 53.0 COG4270@1|root,COG4270@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DoxX_2 CMS1_k127_4526676_75 1206741.BAFX01000004_gene5474 3.196e-28 117.0 COG0596@1|root,COG0596@2|Bacteria,2GU04@201174|Actinobacteria 201174|Actinobacteria S Alpha beta hydrolase - - - - - - - - - - - - - CMS1_k127_4526676_24 1340493.JNIF01000004_gene703 3.777e-129 442.0 COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria 57723|Acidobacteria E peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS1_k127_4526676_55 234267.Acid_0781 8.652e-55 205.0 COG0697@1|root,COG0697@2|Bacteria,3Y4XS@57723|Acidobacteria 57723|Acidobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_4526676_65 479434.Sthe_2734 3.039e-38 151.0 COG5516@1|root,COG5516@2|Bacteria,2G7GV@200795|Chloroflexi 200795|Chloroflexi S Putative stress-induced transcription regulator - - - - - - - - - - - - ABATE,zf-CGNR CMS1_k127_4526676_74 118173.KB235914_gene2476 2.869e-29 125.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_N CMS1_k127_4526676_68 1179773.BN6_43420 1.246e-34 153.0 COG1073@1|root,COG1073@2|Bacteria,2IA0F@201174|Actinobacteria,4E9Z1@85010|Pseudonocardiales 201174|Actinobacteria S Alpha/beta hydrolase of unknown function (DUF1100) - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 CMS1_k127_4526676_23 2002.JOEQ01000003_gene2490 4.702e-131 437.0 COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4EI60@85012|Streptosporangiales 201174|Actinobacteria EK Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_4526676_72 861299.J421_2829 4.013e-30 131.0 2F5V8@1|root,33YE7@2|Bacteria,1ZUZ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4249) - - - - - - - - - - - - DUF4249 CMS1_k127_4526676_21 861299.J421_2830 1.578e-133 455.0 COG1629@1|root,COG4771@2|Bacteria,1ZU8C@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - Plug CMS1_k127_4526676_87 555088.DealDRAFT_0430 2.886e-15 90.0 COG0697@1|root,COG0697@2|Bacteria,1TRTP@1239|Firmicutes,25CFI@186801|Clostridia 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_4526676_9 479434.Sthe_3293 3.717e-194 619.0 COG0154@1|root,COG0154@2|Bacteria,2G7KI@200795|Chloroflexi,27YVS@189775|Thermomicrobia 189775|Thermomicrobia J Amidase - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase CMS1_k127_4526676_12 926569.ANT_23280 8.324e-168 547.0 COG0520@1|root,COG0520@2|Bacteria,2G85X@200795|Chloroflexi 200795|Chloroflexi H Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS1_k127_4526676_43 485913.Krac_2435 2.119e-87 326.0 COG1319@1|root,COG1319@2|Bacteria 2|Bacteria C xanthine dehydrogenase activity hcrB - 1.3.7.9 ko:K04109 ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220 - R05316 RC00490 ko00000,ko00001,ko01000 - - - CO_deh_flav_C,FAD_binding_5 CMS1_k127_4526676_3 1382306.JNIM01000001_gene1023 2.038e-288 916.0 COG1529@1|root,COG1529@2|Bacteria 2|Bacteria C xanthine dehydrogenase activity hcrA - 1.3.7.9 ko:K04108 ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220 - R05316 RC00490 ko00000,ko00001,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 CMS1_k127_4526676_52 1382306.JNIM01000001_gene1022 3.717e-62 219.0 COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi 200795|Chloroflexi C 2Fe-2S -binding domain protein - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 CMS1_k127_4526676_83 379066.GAU_0167 4.927e-20 93.0 COG2924@1|root,COG2924@2|Bacteria,1ZTWZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic CMS1_k127_4526676_95 479433.Caci_1944 8.941e-08 58.0 2DG6U@1|root,2ZURF@2|Bacteria,2HCGM@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_4526676_26 1121124.JNIX01000010_gene788 2.049e-127 424.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2KI2D@204458|Caulobacterales 204458|Caulobacterales E PFAM peptidase M19 renal dipeptidase - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 CMS1_k127_4526676_61 1122137.AQXF01000003_gene2416 2.787e-40 154.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2UGES@28211|Alphaproteobacteria 28211|Alphaproteobacteria J PFAM Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP CMS1_k127_4526676_96 1356852.N008_19955 4.179e-06 58.0 2DNSC@1|root,32YWT@2|Bacteria,4NVHW@976|Bacteroidetes,47VS9@768503|Cytophagia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_4526676_63 459495.SPLC1_S201500 1.143e-39 164.0 COG1392@1|root,COG1392@2|Bacteria,1G5NA@1117|Cyanobacteria 1117|Cyanobacteria P Phosphate transport regulator - - - ko:K07220 - - - - ko00000 - - - PhoU_div CMS1_k127_4526676_29 102125.Xen7305DRAFT_00033680 3.724e-121 398.0 COG0306@1|root,COG0306@2|Bacteria 2|Bacteria P phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 CMS1_k127_4526676_58 861299.J421_1590 6.554e-50 201.0 COG0083@1|root,COG0083@2|Bacteria 2|Bacteria E homoserine kinase activity thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620 GHMP_kinases_C,GHMP_kinases_N CMS1_k127_4526676_19 404589.Anae109_3605 2.62e-141 459.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WK53@28221|Deltaproteobacteria,2YTVW@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_4526676_8 379066.GAU_2504 4.83e-204 662.0 COG2091@1|root,COG2091@2|Bacteria,1ZUKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - CMS1_k127_4526676_22 215803.DB30_3561 4.495e-132 443.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWSR@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_4526676_40 215803.DB30_3562 2.004e-93 325.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42U6K@68525|delta/epsilon subdivisions,2WQ4K@28221|Deltaproteobacteria,2YZCG@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_D23 CMS1_k127_4526676_36 379066.GAU_1146 4.253e-100 337.0 COG1136@1|root,COG1136@2|Bacteria,1ZSKH@142182|Gemmatimonadetes 142182|Gemmatimonadetes V membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_4526676_48 215803.DB30_3564 1.024e-73 264.0 COG1538@1|root,COG1538@2|Bacteria,1Q54P@1224|Proteobacteria,42NQV@68525|delta/epsilon subdivisions,2X5KQ@28221|Deltaproteobacteria,2YYUS@29|Myxococcales 28221|Deltaproteobacteria M Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS1_k127_4526676_99 861299.J421_2430 5.494e-05 51.0 298DU@1|root,2ZVJ1@2|Bacteria,1ZU76@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4526676_62 379066.GAU_0527 1.057e-39 154.0 COG1595@1|root,COG1595@2|Bacteria,1ZT0A@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4526676_49 861299.J421_2433 9.313e-72 266.0 COG2316@1|root,COG2316@2|Bacteria,1ZTH6@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD CMS1_k127_4526676_33 243233.MCA0472 2.885e-105 367.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1XDVZ@135618|Methylococcales 135618|Methylococcales F PFAM Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS1_k127_4526676_54 525903.Taci_0282 1.757e-55 214.0 COG1807@1|root,COG1807@2|Bacteria,3TAR6@508458|Synergistetes 508458|Synergistetes M PFAM glycosyl transferase family 39 - - 2.4.2.43 ko:K07264 ko01503,map01503 M00721 R09773,R09774,R09781 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - - - PMT_2 CMS1_k127_4526676_13 326427.Cagg_3345 6.033e-166 542.0 COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi,374RM@32061|Chloroflexia 32061|Chloroflexia IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C CMS1_k127_4526676_78 1242864.D187_008590 2.028e-24 117.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 CMS1_k127_4526676_46 266117.Rxyl_2676 3.72e-76 268.0 COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4CTQB@84995|Rubrobacteria 84995|Rubrobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD CMS1_k127_4526676_14 861299.J421_2444 2.439e-158 517.0 COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1ZTG4@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase alpha chain like domain - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_thumb,HHH_5 CMS1_k127_4526676_47 1379270.AUXF01000004_gene3357 2.362e-74 259.0 COG0596@1|root,COG0596@2|Bacteria,1ZTAV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Serine aminopeptidase, S33 - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_6 CMS1_k127_4526676_79 661478.OP10G_3830 3.131e-24 119.0 COG1956@1|root,COG1956@2|Bacteria 2|Bacteria T GAF domain-containing protein yebR - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF,GAF_2 CMS1_k127_4526676_42 861299.J421_2448 1.853e-89 312.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,1ZTZW@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS1_k127_4526676_80 861299.J421_2449 1.168e-22 113.0 COG1413@1|root,COG1413@2|Bacteria,1ZTWT@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS1_k127_4526676_69 861299.J421_2449 3.193e-34 149.0 COG1413@1|root,COG1413@2|Bacteria,1ZTWT@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS1_k127_4526676_27 383372.Rcas_0232 2.594e-126 415.0 COG1363@1|root,COG1363@2|Bacteria,2G5WS@200795|Chloroflexi,376QF@32061|Chloroflexia 32061|Chloroflexia G PFAM peptidase M18 aminopeptidase I - - - - - - - - - - - - Peptidase_M42 CMS1_k127_4526676_98 1227495.C487_15564 2.779e-05 53.0 arCOG03838@1|root,arCOG03838@2157|Archaea,2XXT9@28890|Euryarchaeota,23W8X@183963|Halobacteria 183963|Halobacteria H Coenzyme PQQ synthesis protein D (PqqD) - - - - - - - - - - - - PqqD CMS1_k127_4526676_4 880073.Calab_3693 3.078e-244 772.0 COG1297@1|root,COG1297@2|Bacteria,2NPP0@2323|unclassified Bacteria 2|Bacteria S OPT oligopeptide transporter protein oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT CMS1_k127_4526676_30 1408473.JHXO01000011_gene3050 4.179e-121 412.0 COG2195@1|root,COG2195@2|Bacteria,4NG8I@976|Bacteroidetes,2FM0V@200643|Bacteroidia 976|Bacteroidetes E Xaa-His dipeptidase pepD_2 - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 CMS1_k127_4526676_15 1184267.A11Q_1340 3.399e-158 512.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2MSRZ@213481|Bdellovibrionales,2WJ3Z@28221|Deltaproteobacteria 213481|Bdellovibrionales C acyl-coa dehydrogenase bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_4526676_102 1379270.AUXF01000003_gene3669 0.0001634 53.0 2F5SD@1|root,33YB8@2|Bacteria,1ZUXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4526676_20 661478.OP10G_2269 3.304e-141 467.0 COG0274@1|root,COG0274@2|Bacteria 2|Bacteria F deoxyribose-phosphate aldolase activity deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC CMS1_k127_4526676_1 1128421.JAGA01000003_gene3726 0.0 1091.0 COG1012@1|root,COG1012@2|Bacteria,2NNWB@2323|unclassified Bacteria 2|Bacteria C Belongs to the aldehyde dehydrogenase family aldA - 1.2.1.3,1.2.1.8 ko:K00128,ko:K00130,ko:K00138 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS1_k127_4526676_39 1156919.QWC_26283 1.128e-94 341.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,3T8VD@506|Alcaligenaceae 28216|Betaproteobacteria M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel CMS1_k127_4526676_50 330214.NIDE3094 1.9e-70 253.0 COG4221@1|root,COG4221@2|Bacteria 2|Bacteria IQ oxidoreductase activity - - - - - - - - - - - - adh_short CMS1_k127_4526676_5 379066.GAU_0558 1.567e-216 695.0 COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Methylenetetrahydrofolate reductase - - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR,S-methyl_trans CMS1_k127_4526676_0 396588.Tgr7_0650 0.0 1583.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans CMS1_k127_4526676_16 1121920.AUAU01000013_gene1755 1.207e-157 514.0 COG2326@1|root,COG2326@2|Bacteria,3Y5E4@57723|Acidobacteria 57723|Acidobacteria S Polyphosphate kinase 2 (PPK2) - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 CMS1_k127_4526676_82 1379270.AUXF01000001_gene2745 4.665e-20 105.0 COG5349@1|root,COG5349@2|Bacteria,1ZU3C@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF983) - - - - - - - - - - - - DUF983 CMS1_k127_4526676_77 272134.KB731324_gene1198 3.693e-26 111.0 COG3695@1|root,COG3695@2|Bacteria,1G82G@1117|Cyanobacteria,1HCND@1150|Oscillatoriales 1117|Cyanobacteria L Methylated dna-protein cysteine methyltransferase - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 CMS1_k127_4526676_59 1500259.JQLD01000005_gene108 3.123e-46 181.0 COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,2U39G@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Esterase PHB depolymerase - - - ko:K03932 - - - - ko00000 - CE1 - Abhydrolase_2,Esterase_phd CMS1_k127_4526676_81 449447.MAE_52075 2.454e-22 100.0 COG1950@1|root,COG1950@2|Bacteria,1G7RB@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 CMS1_k127_4526676_76 204669.Acid345_3839 6.193e-27 117.0 COG0457@1|root,COG0457@2|Bacteria,3Y893@57723|Acidobacteria,2JNSA@204432|Acidobacteriia 204432|Acidobacteriia S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_4526676_86 1122201.AUAZ01000007_gene3715 6.474e-16 81.0 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,468EX@72275|Alteromonadaceae 1236|Gammaproteobacteria S DUF167 yggU - - ko:K09131 - - - - ko00000 - - - DUF167 CMS1_k127_4526676_32 1121904.ARBP01000009_gene4348 2.42e-116 389.0 COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes,47MH5@768503|Cytophagia 976|Bacteroidetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS1_k127_4526676_28 391625.PPSIR1_39705 9.04e-123 414.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42V54@68525|delta/epsilon subdivisions,2WSDI@28221|Deltaproteobacteria,2Z0J9@29|Myxococcales 28221|Deltaproteobacteria BQ Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl CMS1_k127_4526676_73 861299.J421_2472 1.227e-29 125.0 COG0762@1|root,COG0762@2|Bacteria,1ZTUJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT CMS1_k127_4526676_100 379066.GAU_0510 8.969e-05 51.0 2DW4B@1|root,33YGG@2|Bacteria,1ZV12@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4526676_2 518766.Rmar_2370 7.982e-298 955.0 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,4NEU9@976|Bacteroidetes,1FITW@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C 2-oxoglutarate dehydrogenase N-terminus sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr CMS1_k127_4526676_56 1379270.AUXF01000005_gene468 8.068e-54 202.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran CMS1_k127_4526676_35 224911.27350542 3.378e-101 353.0 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,2V7DW@28211|Alphaproteobacteria,3JXAY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,PAS_8,PAS_9,Response_reg CMS1_k127_4526676_90 326427.Cagg_2555 9.135e-15 89.0 COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2G93H@200795|Chloroflexi,375J3@32061|Chloroflexia 32061|Chloroflexia T PFAM Sulfate transporter antisigma-factor antagonist STAS - - 2.7.11.1 ko:K04749,ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2,STAS CMS1_k127_4526676_89 1437824.BN940_04216 5.526e-15 79.0 COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,2VWEF@28216|Betaproteobacteria,3T4V7@506|Alcaligenaceae 28216|Betaproteobacteria T Belongs to the anti-sigma-factor antagonist family btrV - - ko:K06378 - - - - ko00000 - - - STAS,STAS_2 CMS1_k127_4526676_53 1458275.AZ34_10025 1.366e-58 219.0 COG1752@1|root,COG1752@2|Bacteria,1MX8Y@1224|Proteobacteria,2VKNF@28216|Betaproteobacteria 28216|Betaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin CMS1_k127_4526676_38 1173263.Syn7502_01686 4.915e-96 330.0 COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1G3MK@1117|Cyanobacteria,1GZ7I@1129|Synechococcus 1117|Cyanobacteria T Serine phosphatase RsbU, regulator of sigma subunit - - - - - - - - - - - - HAMP,HisKA,Response_reg,SpoIIE CMS1_k127_4526676_45 321327.CYA_2781 2.205e-77 263.0 COG1225@1|root,COG1225@2|Bacteria,1G0JC@1117|Cyanobacteria,1GZAU@1129|Synechococcus 1117|Cyanobacteria O COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA CMS1_k127_4526676_17 1254432.SCE1572_19990 3.139e-153 498.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2YUPM@29|Myxococcales 28221|Deltaproteobacteria P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 CMS1_k127_4526676_10 861299.J421_2513 6.308e-190 602.0 COG4867@1|root,COG4867@2|Bacteria,1ZT0B@142182|Gemmatimonadetes 142182|Gemmatimonadetes S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA_2 CMS1_k127_4526676_84 1189620.AJXL01000082_gene2836 1.07e-19 95.0 2DNS7@1|root,32YWC@2|Bacteria,4NSJ6@976|Bacteroidetes,1I4FI@117743|Flavobacteriia,2NXP6@237|Flavobacterium 976|Bacteroidetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP CMS1_k127_4526676_44 448385.sce4660 1.339e-81 286.0 COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMH@68525|delta/epsilon subdivisions,2X6ZP@28221|Deltaproteobacteria,2Z3JZ@29|Myxococcales 28221|Deltaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 CMS1_k127_4526676_25 1379270.AUXF01000006_gene39 5.84e-128 443.0 COG1629@1|root,COG4771@2|Bacteria,1ZST4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P CarboxypepD_reg-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec CMS1_k127_4526676_57 880073.Calab_3376 2.315e-52 192.0 COG3295@1|root,COG3295@2|Bacteria 2|Bacteria C Protein conserved in bacteria - - - ko:K09939 - - - - ko00000 - - - PepSY_TM,PepSY_TM_like_2 CMS1_k127_4526676_70 485913.Krac_11720 3.806e-32 134.0 COG1102@1|root,COG1102@2|Bacteria 2|Bacteria F Psort location Cytoplasmic, score - - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin2 CMS1_k127_4526676_6 861299.J421_2518 4.236e-211 666.0 COG1239@1|root,COG1239@2|Bacteria,1ZT0R@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - - CMS1_k127_4526676_41 574087.Acear_0488 8.829e-90 323.0 COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,248DM@186801|Clostridia 186801|Clostridia P H( )-stimulated, divalent metal cation uptake system mntH - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp CMS1_k127_4526676_71 1379270.AUXF01000004_gene3295 5.935e-32 145.0 COG0354@1|root,COG0354@2|Bacteria,1ZTMX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Glycine cleavage T-protein C-terminal barrel domain - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C CMS1_k127_4526676_34 1379270.AUXF01000004_gene3287 2.8e-104 353.0 COG0247@1|root,COG0247@2|Bacteria,1ZSTK@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S binding domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG CMS1_k127_4526676_66 1173028.ANKO01000135_gene2513 3.115e-37 157.0 COG0277@1|root,COG0277@2|Bacteria,1G176@1117|Cyanobacteria,1H7RA@1150|Oscillatoriales 1117|Cyanobacteria C FAD linked oxidases, C-terminal domain glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 CMS1_k127_4526676_11 379066.GAU_0600 3.199e-173 567.0 COG0277@1|root,COG0277@2|Bacteria,1ZT11@142182|Gemmatimonadetes 142182|Gemmatimonadetes C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 CMS1_k127_4526676_67 861299.J421_2526 1.204e-36 147.0 COG2802@1|root,COG2802@2|Bacteria,1ZUZ8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATP-dependent protease La (LON) substrate-binding domain - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - LON_substr_bdg CMS1_k127_4541256_6 204669.Acid345_2395 2.211e-167 546.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K08282,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16,TPR_2,TPR_8 CMS1_k127_4541256_35 861299.J421_3991 5.098e-35 145.0 29F5I@1|root,30238@2|Bacteria,1ZU4C@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4541256_21 861299.J421_2596 5.855e-74 275.0 2EW4E@1|root,33PHK@2|Bacteria,1ZT53@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4541256_7 379066.GAU_0649 2.102e-147 487.0 COG2204@1|root,COG2204@2|Bacteria,1ZSW0@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_4541256_27 1379270.AUXF01000004_gene3229 1.458e-60 224.0 COG5000@1|root,COG5000@2|Bacteria,1ZTBX@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA CMS1_k127_4541256_47 1121091.AUMP01000005_gene1676 3.951e-07 59.0 COG4549@1|root,COG4549@2|Bacteria,1V3Z6@1239|Firmicutes,4HHT8@91061|Bacilli 91061|Bacilli S Domain of unkown function (DUF1775) - - - - - - - - - - - - DUF1775 CMS1_k127_4541256_33 575540.Isop_0872 1.636e-36 160.0 COG1845@1|root,COG1845@2|Bacteria,2IYXN@203682|Planctomycetes 203682|Planctomycetes C Heme copper-type cytochrome quinol oxidase, subunit - - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 CMS1_k127_4541256_3 314230.DSM3645_19538 5.541e-210 672.0 COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes 203682|Planctomycetes C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 CMS1_k127_4541256_28 886293.Sinac_6885 1.474e-59 213.0 COG1622@1|root,COG1622@2|Bacteria,2IZBI@203682|Planctomycetes 203682|Planctomycetes C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM CMS1_k127_4541256_29 639030.JHVA01000001_gene2022 7.437e-58 211.0 COG3794@1|root,COG3794@2|Bacteria,3Y4C0@57723|Acidobacteria,2JJME@204432|Acidobacteriia 204432|Acidobacteriia C Polysaccharide lyase family 4, domain II - - - - - - - - - - - - CarboxypepD_reg CMS1_k127_4541256_20 247490.KSU1_B0265 2.331e-77 278.0 COG2010@1|root,COG2010@2|Bacteria,2IZN4@203682|Planctomycetes 203682|Planctomycetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3,EB_dh CMS1_k127_4541256_24 1049564.TevJSym_ac00580 2.472e-67 247.0 COG2010@1|root,COG2010@2|Bacteria,1R28S@1224|Proteobacteria,1T5JD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 CMS1_k127_4541256_44 550540.Fbal_2044 3.238e-15 90.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MVYW@1224|Proteobacteria,1RY2R@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2 - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C CMS1_k127_4541256_5 1049564.TevJSym_ac00600 5.029e-173 560.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain - - 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 - - Cyt_bd_oxida_I,Cytochrome_CBB3 CMS1_k127_4541256_15 237368.SCABRO_00348 5.923e-104 360.0 COG0535@1|root,COG0535@2|Bacteria,2J2KS@203682|Planctomycetes 203682|Planctomycetes S Proto-chlorophyllide reductase 57 kD subunit - - - - - - - - - - - - PCP_red,Radical_SAM,SPASM CMS1_k127_4541256_17 266117.Rxyl_0436 2.871e-89 319.0 COG0589@1|root,COG1592@1|root,COG1773@1|root,COG0589@2|Bacteria,COG1592@2|Bacteria,COG1773@2|Bacteria 2|Bacteria C rubredoxin hrb - 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavin_Reduct,Lactamase_B,Rubredoxin,Rubrerythrin,Usp CMS1_k127_4541256_45 1089550.ATTH01000001_gene1930 8.293e-10 65.0 COG1141@1|root,COG1141@2|Bacteria,4PF9R@976|Bacteroidetes,1FKC0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C 4Fe-4S single cluster domain of Ferredoxin I - - - - - - - - - - - - - CMS1_k127_4541256_41 330214.NIDE0413 4.862e-19 98.0 2DQ3Q@1|root,334KX@2|Bacteria 2|Bacteria S Proto-chlorophyllide reductase 57 kd subunit bchB - - - - - - - - - - - PCP_red CMS1_k127_4541256_32 330214.NIDE0412 1.902e-47 183.0 COG0489@1|root,COG0489@2|Bacteria 2|Bacteria D protein tyrosine kinase activity - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - ParA CMS1_k127_4541256_46 215803.DB30_5792 1.878e-07 60.0 2DP1D@1|root,3304P@2|Bacteria,1R5XI@1224|Proteobacteria,4386M@68525|delta/epsilon subdivisions,2X9ZN@28221|Deltaproteobacteria,2YVZY@29|Myxococcales 28221|Deltaproteobacteria S HmuY protein - - - - - - - - - - - - HmuY CMS1_k127_4541256_39 861299.J421_2404 2.444e-24 112.0 2DW4B@1|root,33YGG@2|Bacteria,1ZV12@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4541256_36 420324.KI912086_gene7360 1.458e-34 152.0 COG3678@1|root,COG3678@2|Bacteria,1PZJ1@1224|Proteobacteria,2V2M9@28211|Alphaproteobacteria,1JYPK@119045|Methylobacteriaceae 28211|Alphaproteobacteria NPTU ATP-independent chaperone mediated protein folding - - - - - - - - - - - - - CMS1_k127_4541256_2 518766.Rmar_1564 1.651e-249 788.0 COG0843@1|root,COG0843@2|Bacteria,4P06K@976|Bacteroidetes,1FJ2A@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C cytochrome c oxidase subunit I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 CMS1_k127_4541256_25 518766.Rmar_1565 2.46e-65 226.0 COG1622@1|root,COG1622@2|Bacteria,4P5ZE@976|Bacteroidetes,1FJK0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Cytochrome C oxidase subunit II, periplasmic domain - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 CMS1_k127_4541256_23 502025.Hoch_6599 1.828e-67 244.0 COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1QA4K@1224|Proteobacteria,42V3B@68525|delta/epsilon subdivisions,2WRIN@28221|Deltaproteobacteria,2YW0I@29|Myxococcales 28221|Deltaproteobacteria E Prephenate dehydrogenase chorismate mutase - - 1.3.1.12 ko:K00210 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - CM_2,PDH CMS1_k127_4541256_4 309807.SRU_2648 6.564e-175 588.0 COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,1FIRV@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain - - - - - - - - - - - - ABC_transp_aux,Peptidase_M14 CMS1_k127_4541256_38 1121013.P873_05025 4.973e-30 132.0 COG0265@1|root,COG0265@2|Bacteria,1PCJA@1224|Proteobacteria,1SXM8@1236|Gammaproteobacteria,1X6DM@135614|Xanthomonadales 135614|Xanthomonadales O PDZ domain - - - - - - - - - - - - PDZ_2 CMS1_k127_4541256_34 935863.AWZR01000007_gene217 8.212e-36 144.0 COG1595@1|root,COG1595@2|Bacteria,1QDHS@1224|Proteobacteria,1SS07@1236|Gammaproteobacteria,1X6DE@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4541256_1 379066.GAU_0518 0.0 1067.0 COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 CMS1_k127_4541256_37 1382304.JNIL01000001_gene1501 7.122e-32 144.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,2780F@186823|Alicyclobacillaceae 91061|Bacilli T Cache_2 tlpA3 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 CMS1_k127_4541256_13 999423.HMPREF9161_00698 1.983e-111 393.0 COG0111@1|root,COG2150@1|root,COG0111@2|Bacteria,COG2150@2|Bacteria,1V410@1239|Firmicutes,4H2KQ@909932|Negativicutes 909932|Negativicutes E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT CMS1_k127_4541256_18 861299.J421_1678 2.897e-84 292.0 COG0075@1|root,COG0075@2|Bacteria,1ZTF3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS1_k127_4541256_8 469383.Cwoe_5866 1.125e-143 473.0 COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4CQTG@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP - - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - Isochorismatase,QRPTase_C,QRPTase_N CMS1_k127_4541256_26 1121440.AUMA01000017_gene305 1.808e-61 220.0 COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,43BKJ@68525|delta/epsilon subdivisions,2WIZJ@28221|Deltaproteobacteria,2M9AT@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_4541256_12 1379270.AUXF01000002_gene1837 8.738e-113 380.0 COG1446@1|root,COG1446@2|Bacteria,1ZTAQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Asparaginase - - 3.5.1.26 ko:K01444 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Asparaginase_2 CMS1_k127_4541256_42 1242864.D187_008463 3.063e-17 96.0 COG4775@1|root,COG4775@2|Bacteria,1RDM0@1224|Proteobacteria,42S2Q@68525|delta/epsilon subdivisions,2WNSG@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Surface antigen - - - - - - - - - - - - Bac_surface_Ag CMS1_k127_4541256_11 379066.GAU_0501 2.371e-131 432.0 COG1748@1|root,COG1748@2|Bacteria,1ZSMC@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Saccharopine dehydrogenase C-terminal domain - - 1.4.1.18 ko:K19064 ko00960,ko01100,ko01110,map00960,map01100,map01110 - R00446,R02317 RC00062,RC00694 ko00000,ko00001,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP CMS1_k127_4541256_43 1235279.C772_00906 9.633e-17 89.0 COG1309@1|root,COG1309@2|Bacteria,1V95E@1239|Firmicutes,4HJIZ@91061|Bacilli 91061|Bacilli K Transcriptional regulator - - - ko:K22106 - - - - ko00000,ko03000 - - - TetR_C_10,TetR_N CMS1_k127_4541256_10 404589.Anae109_3037 6.603e-133 437.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2WJZA@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF CMS1_k127_4541256_16 338963.Pcar_0624 5.391e-99 340.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,42MU3@68525|delta/epsilon subdivisions,2WKTF@28221|Deltaproteobacteria,43SSU@69541|Desulfuromonadales 28221|Deltaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH CMS1_k127_4541256_31 861299.J421_3598 3.259e-51 197.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 2|Bacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) bfmBA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C CMS1_k127_4541256_19 571166.KI421509_gene2107 6.394e-83 297.0 COG0265@1|root,COG1716@1|root,COG0265@2|Bacteria,COG1716@2|Bacteria,1NT6K@1224|Proteobacteria,2UPAI@28211|Alphaproteobacteria 28211|Alphaproteobacteria OT Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 CMS1_k127_4541256_14 1340493.JNIF01000003_gene3520 1.484e-106 360.0 COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria 57723|Acidobacteria Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_1 CMS1_k127_4541256_30 379066.GAU_3864 1.263e-57 226.0 COG0515@1|root,COG3170@1|root,COG0515@2|Bacteria,COG3170@2|Bacteria,1ZTGA@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4541256_9 861299.J421_2398 1.701e-141 477.0 COG0745@1|root,COG2199@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1ZT7F@142182|Gemmatimonadetes 142182|Gemmatimonadetes T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg CMS1_k127_4541256_22 861299.J421_2397 5.811e-73 257.0 COG1171@1|root,COG1171@2|Bacteria,1ZTBP@142182|Gemmatimonadetes 2|Bacteria E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_4541256_0 861299.J421_2396 0.0 1121.0 COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV CMS1_k127_4570801_1 1379270.AUXF01000002_gene1600 1.068e-131 439.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4570801_3 1379270.AUXF01000007_gene994 4.805e-14 81.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4570801_2 203275.BFO_1521 5.801e-46 178.0 COG1208@1|root,COG1208@2|Bacteria,4NMJ5@976|Bacteroidetes,2FNEE@200643|Bacteroidia,22XKJ@171551|Porphyromonadaceae 976|Bacteroidetes JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) hddC - - - - - - - - - - - NTP_transferase CMS1_k127_4570801_0 1408473.JHXO01000005_gene1758 1.344e-142 466.0 COG1660@1|root,COG3178@1|root,COG1660@2|Bacteria,COG3178@2|Bacteria,4NIT0@976|Bacteroidetes,2FMEM@200643|Bacteroidia 976|Bacteroidetes S Phosphotransferase enzyme family - - - - - - - - - - - - APH,ATP_bind_2 CMS1_k127_4575404_9 379066.GAU_3626 1.576e-104 357.0 COG1538@1|root,COG1538@2|Bacteria,1ZUIP@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS1_k127_4575404_1 379066.GAU_3627 4.341e-171 551.0 COG0577@1|root,COG0577@2|Bacteria,1ZUAJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_4575404_4 379066.GAU_3628 1.318e-149 491.0 COG0845@1|root,COG0845@2|Bacteria,1ZUCP@142182|Gemmatimonadetes 142182|Gemmatimonadetes M HlyD family secretion protein - - - - - - - - - - - - - CMS1_k127_4575404_10 671143.DAMO_0982 3.704e-102 362.0 COG0535@1|root,COG0535@2|Bacteria,2NQVH@2323|unclassified Bacteria 2|Bacteria S Elongator protein 3, MiaB family, Radical SAM pqqE - - ko:K22226,ko:K22227 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM CMS1_k127_4575404_2 479434.Sthe_1801 2.198e-165 533.0 COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,27Y34@189775|Thermomicrobia 189775|Thermomicrobia H Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_4575404_7 479434.Sthe_2327 8.988e-115 392.0 COG1232@1|root,COG1232@2|Bacteria,2G687@200795|Chloroflexi,27XMR@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase CMS1_k127_4575404_11 479434.Sthe_2326 4.314e-86 305.0 COG0276@1|root,COG0276@2|Bacteria,2G6A2@200795|Chloroflexi,27XJN@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase CMS1_k127_4575404_3 479434.Sthe_2324 1.714e-150 494.0 COG0407@1|root,COG0407@2|Bacteria,2G5NU@200795|Chloroflexi,27XWH@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D CMS1_k127_4575404_15 661478.OP10G_0939 1.423e-50 188.0 COG3253@1|root,COG3253@2|Bacteria 2|Bacteria S peroxidase activity - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 ko:K09162 - - - - ko00000,ko01000 - - - Chlor_dismutase CMS1_k127_4575404_6 926550.CLDAP_19120 2.136e-117 389.0 COG0113@1|root,COG0113@2|Bacteria,2G5QT@200795|Chloroflexi 200795|Chloroflexi H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD CMS1_k127_4575404_16 1430331.EP10_09515 5.562e-42 171.0 COG1587@1|root,COG1587@2|Bacteria,1UHSJ@1239|Firmicutes,4HFY4@91061|Bacilli,1WF9W@129337|Geobacillus 91061|Bacilli H Uroporphyrinogen-III synthase HemD hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 CMS1_k127_4575404_13 679201.HMPREF9334_00267 1.816e-67 256.0 COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,4H1XA@909932|Negativicutes 909932|Negativicutes H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC CMS1_k127_4575404_12 644966.Tmar_1263 5.354e-76 272.0 COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,3WDC1@538999|Clostridiales incertae sedis 186801|Clostridia H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH CMS1_k127_4575404_14 326427.Cagg_2663 3.55e-52 192.0 COG0634@1|root,COG0634@2|Bacteria,2G6HX@200795|Chloroflexi 200795|Chloroflexi F Belongs to the purine pyrimidine phosphoribosyltransferase family - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran CMS1_k127_4575404_0 518766.Rmar_2521 2.221e-202 651.0 COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,1FKC5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_4575404_21 1121104.AQXH01000001_gene889 1.294e-06 61.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,NHL,Yip1 CMS1_k127_4575404_20 903818.KI912268_gene2486 1.751e-07 63.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4,MucBP CMS1_k127_4575404_17 1280944.HY17_07285 4.504e-40 170.0 COG1228@1|root,COG4946@1|root,COG1228@2|Bacteria,COG4946@2|Bacteria,1QVGM@1224|Proteobacteria,2TWFQ@28211|Alphaproteobacteria,440P6@69657|Hyphomonadaceae 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_4575404_8 861299.J421_5836 1.167e-105 363.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_4575404_5 234267.Acid_3470 2.559e-145 494.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_4575404_19 760117.JN27_23190 9.437e-08 65.0 COG1555@1|root,COG1555@2|Bacteria,1NW2I@1224|Proteobacteria 1224|Proteobacteria L photosystem II stabilization - - - - - - - - - - - - - CMS1_k127_4578317_52 1378168.N510_01882 8.476e-08 62.0 COG0582@1|root,COG0582@2|Bacteria,1TPCB@1239|Firmicutes 1239|Firmicutes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase CMS1_k127_4578317_2 861299.J421_3741 2.808e-265 829.0 COG1217@1|root,COG1217@2|Bacteria,1ZT8A@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Elongation factor G C-terminus - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 CMS1_k127_4578317_28 1489678.RDMS_12985 7.601e-72 258.0 COG1230@1|root,COG1230@2|Bacteria 2|Bacteria P cation diffusion facilitator family transporter zitB GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - iNRG857_1313.NRG857_03325,iPC815.YPO1129 Cation_efflux,ZT_dimer CMS1_k127_4578317_20 861299.J421_3744 3.946e-89 303.0 COG1995@1|root,COG1995@2|Bacteria,1ZT2S@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pyridoxal phosphate biosynthetic protein PdxA - - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA CMS1_k127_4578317_22 861299.J421_3745 9.352e-85 302.0 COG0760@1|root,COG0760@2|Bacteria,1ZSU2@142182|Gemmatimonadetes 142182|Gemmatimonadetes O SurA N-terminal domain - - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3,SurA_N_3 CMS1_k127_4578317_53 983917.RGE_16260 9.361e-08 64.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,1KJR8@119065|unclassified Burkholderiales 28216|Betaproteobacteria O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 CMS1_k127_4578317_4 518766.Rmar_2754 5.12e-225 758.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,1FIP1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF CMS1_k127_4578317_33 379066.GAU_2149 1.044e-66 252.0 COG2304@1|root,COG2304@2|Bacteria,1ZT05@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA CMS1_k127_4578317_24 1379270.AUXF01000003_gene3696 1.319e-82 284.0 COG1721@1|root,COG1721@2|Bacteria,1ZT0H@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 CMS1_k127_4578317_50 1489678.RDMS_13120 1.421e-10 73.0 COG5479@1|root,COG5479@2|Bacteria,1WMPI@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M Domain of unknown function (DUF4384) - - - - - - - - - - - - DUF4384,LGFP CMS1_k127_4578317_32 1123269.NX02_26020 7.945e-67 250.0 COG2234@1|root,COG2234@2|Bacteria,1MUZ7@1224|Proteobacteria,2TRSJ@28211|Alphaproteobacteria,2K00G@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase, M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_4578317_7 1379270.AUXF01000004_gene3294 6.571e-176 562.0 COG0006@1|root,COG0006@2|Bacteria,1ZSTY@142182|Gemmatimonadetes 2|Bacteria E Creatinase/Prolidase N-terminal domain pepQ - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 CMS1_k127_4578317_1 379066.GAU_2152 6.462e-291 904.0 COG0481@1|root,COG0481@2|Bacteria,1ZTGT@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,LepA_C CMS1_k127_4578317_35 379066.GAU_2153 7.335e-59 220.0 COG0859@1|root,COG0859@2|Bacteria,1ZSYI@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 CMS1_k127_4578317_13 861299.J421_3753 5.126e-120 410.0 COG1940@1|root,COG1940@2|Bacteria,1ZT66@142182|Gemmatimonadetes 142182|Gemmatimonadetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK CMS1_k127_4578317_18 861299.J421_3754 8.248e-98 331.0 COG0524@1|root,COG0524@2|Bacteria,1ZTFD@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - - - - - - - - - - - CMS1_k127_4578317_17 861299.J421_3755 2.839e-98 343.0 COG0643@1|root,COG0643@2|Bacteria,1ZSPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Histidine kinase-like ATPases - - - - - - - - - - - - - CMS1_k127_4578317_43 379066.GAU_2157 1.232e-25 113.0 2EFCU@1|root,3395Q@2|Bacteria,1ZTVZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4578317_10 861299.J421_3758 4.969e-133 443.0 COG0626@1|root,COG0626@2|Bacteria,1ZUSY@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Cys/Met metabolism PLP-dependent enzyme - - - - - - - - - - - - Cys_Met_Meta_PP CMS1_k127_4578317_23 1379270.AUXF01000003_gene3686 2.16e-83 282.0 COG2884@1|root,COG2884@2|Bacteria,1ZTHQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D ABC transporter - - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran CMS1_k127_4578317_29 861299.J421_3760 1.505e-71 259.0 COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Part of the ABC transporter FtsEX involved in - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - CMS1_k127_4578317_31 379066.GAU_2162 1.583e-68 258.0 COG4942@1|root,COG4942@2|Bacteria,1ZSU6@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 CMS1_k127_4578317_47 178901.AmDm5_2900 2.504e-14 81.0 COG1309@1|root,COG1309@2|Bacteria,1ND64@1224|Proteobacteria,2VF4Q@28211|Alphaproteobacteria,2JS9N@204441|Rhodospirillales 204441|Rhodospirillales K YcdC-like protein, C-terminal region - - - ko:K09017 - - - - ko00000,ko03000 - - - TetR_C_3,TetR_N CMS1_k127_4578317_56 880073.Calab_2257 0.0001088 54.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - - - - - - - - - - OEP CMS1_k127_4578317_26 1123368.AUIS01000024_gene946 5.295e-78 280.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RS3I@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Secretion protein yhiI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_4578317_14 1123368.AUIS01000024_gene947 9.154e-115 382.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NDPN@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_4578317_11 1123368.AUIS01000024_gene948 1.014e-126 413.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NCCI@225057|Acidithiobacillales 225057|Acidithiobacillales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 CMS1_k127_4578317_16 1123368.AUIS01000024_gene949 2.037e-104 364.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,2NBU9@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS1_k127_4578317_15 1123368.AUIS01000024_gene950 1.37e-112 392.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS1_k127_4578317_36 1122197.ATWI01000008_gene2792 2.19e-52 194.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS1_k127_4578317_3 861299.J421_3772 4.458e-230 724.0 COG1866@1|root,COG1866@2|Bacteria,1ZSTT@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP CMS1_k127_4578317_9 861299.J421_3775 1.371e-135 443.0 COG1078@1|root,COG1078@2|Bacteria,1ZT3F@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD CMS1_k127_4578317_19 861299.J421_3777 2.579e-89 302.0 COG0631@1|root,COG0631@2|Bacteria,1ZSYG@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS1_k127_4578317_46 395961.Cyan7425_1548 8.997e-16 90.0 COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1G102@1117|Cyanobacteria,3KGKE@43988|Cyanothece 1117|Cyanobacteria V FHA modulated ABC efflux pump with fused ATPase and integral membrane subunits - - - - - - - - - - - - ABC2_membrane,ABC_tran,FHA CMS1_k127_4578317_44 448385.sce5866 1.596e-25 119.0 COG0392@1|root,COG0392@2|Bacteria,1R959@1224|Proteobacteria 1224|Proteobacteria S integral membrane protein - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS1_k127_4578317_0 1379270.AUXF01000003_gene3672 0.0 1104.0 COG0178@1|root,COG0178@2|Bacteria,1ZT1W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran CMS1_k127_4578317_42 1499967.BAYZ01000095_gene4149 4.622e-30 126.0 COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria 2|Bacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS1_k127_4578317_8 483219.LILAB_10280 2.212e-174 565.0 COG0006@1|root,COG0006@2|Bacteria,1MVHD@1224|Proteobacteria 1224|Proteobacteria E Xaa-Pro aminopeptidase - - - - - - - - - - - - Peptidase_M24 CMS1_k127_4578317_49 313590.MED134_02810 4.082e-11 73.0 COG3637@1|root,COG3637@2|Bacteria,4NR9K@976|Bacteroidetes,1I34P@117743|Flavobacteriia,37EPV@326319|Dokdonia 976|Bacteroidetes M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl_2 CMS1_k127_4578317_34 196367.JNFG01000020_gene4570 4.864e-64 234.0 COG3616@1|root,COG3616@2|Bacteria,1N2SF@1224|Proteobacteria,2VJ58@28216|Betaproteobacteria,1JZSP@119060|Burkholderiaceae 28216|Betaproteobacteria E alanine racemase - - 4.3.1.27 ko:K20757 - - - - ko00000,ko01000 - - - Ala_racemase_N,D-ser_dehydrat CMS1_k127_4578317_21 1499967.BAYZ01000073_gene2025 1.402e-85 310.0 COG0106@1|root,COG0139@1|root,COG0106@2|Bacteria,COG0139@2|Bacteria,2NPDP@2323|unclassified Bacteria 2|Bacteria E Phosphoribosyl-AMP cyclohydrolase hisI GO:0000105,GO:0003674,GO:0003824,GO:0003949,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16 ko:K01496,ko:K01497,ko:K01814,ko:K11755 ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024 M00026,M00125 R00425,R04035,R04037,R04640 RC00002,RC00293,RC00945,RC01055,RC02504 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iHN637.CLJU_RS05760,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186 His_biosynth,PRA-CH,PRA-PH,SseB CMS1_k127_4578317_6 861299.J421_4478 1.849e-188 605.0 COG1574@1|root,COG1574@2|Bacteria,1ZU9S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 CMS1_k127_4578317_30 379066.GAU_2225 3.258e-69 247.0 COG0470@1|root,COG0470@2|Bacteria,1ZT21@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 CMS1_k127_4578317_37 861299.J421_3798 2.701e-51 187.0 COG0315@1|root,COG0315@2|Bacteria,1ZU6G@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC CMS1_k127_4578317_41 1379270.AUXF01000003_gene3651 2.523e-33 138.0 COG0741@1|root,COG0741@2|Bacteria,1ZTV6@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transglycosylase SLT domain - - - - - - - - - - - - SLT CMS1_k127_4578317_25 1242864.D187_006506 6.835e-82 297.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2YURT@29|Myxococcales 28221|Deltaproteobacteria M Transglycosylase SLT domain mltD2 - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT CMS1_k127_4578317_48 379066.GAU_2229 3.197e-13 75.0 2960H@1|root,2ZTB5@2|Bacteria,1ZU7H@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4578317_38 1304872.JAGC01000009_gene1321 1.14e-48 190.0 COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,42QZX@68525|delta/epsilon subdivisions,2WN5T@28221|Deltaproteobacteria,2MA07@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 CMS1_k127_4578317_54 861299.J421_4475 6.8e-07 62.0 2CA9X@1|root,2ZJY8@2|Bacteria,1ZU1S@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4578317_27 1379270.AUXF01000001_gene2417 1.609e-77 272.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS1_k127_4578317_57 349521.HCH_00276 0.0006528 52.0 COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,1SFPF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NHL repeat - - - - - - - - - - - - NHL CMS1_k127_4578317_45 1379270.AUXF01000002_gene1587 1.025e-19 102.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1587|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4578317_12 861299.J421_6371 2.36e-123 428.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6371|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_4578317_40 1379270.AUXF01000002_gene1600 2.842e-39 158.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4578317_39 1379270.AUXF01000002_gene1589 8.356e-40 157.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4578317_5 671143.DAMO_1249 1.698e-188 615.0 COG1615@1|root,COG1615@2|Bacteria,2NQSF@2323|unclassified Bacteria 2|Bacteria S Uncharacterised protein family (UPF0182) - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K09118 - - - - ko00000 - - - UPF0182 CMS1_k127_4599498_5 929713.NIASO_07765 3.13e-133 429.0 COG3507@1|root,COG3507@2|Bacteria,4NEIZ@976|Bacteroidetes,1IRD7@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 CMS1_k127_4599498_13 379066.GAU_3083 1.15e-23 117.0 2EXVN@1|root,33R4S@2|Bacteria,1ZTD4@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4599498_15 1047013.AQSP01000097_gene1952 1.899e-15 89.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,TolB_like CMS1_k127_4599498_1 335543.Sfum_2336 6.69e-272 844.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,43DIW@68525|delta/epsilon subdivisions,2X8Q7@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumB - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C CMS1_k127_4599498_6 880073.Calab_0498 7.943e-114 376.0 COG0332@1|root,COG0332@2|Bacteria,2NQDW@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180,2.3.1.262 ko:K00648,ko:K18003 ko00061,ko00405,ko01100,ko01130,ko01212,ko02024,ko02025,map00061,map00405,map01100,map01130,map01212,map02024,map02025 M00082,M00083 R10707,R11586,R11587,R11588 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C CMS1_k127_4599498_17 1047013.AQSP01000097_gene1952 1.525e-08 66.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,TolB_like CMS1_k127_4599498_3 861299.J421_4428 2.303e-149 482.0 COG0761@1|root,COG0761@2|Bacteria,1ZTGU@142182|Gemmatimonadetes 142182|Gemmatimonadetes C LytB protein - - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB CMS1_k127_4599498_12 1379270.AUXF01000001_gene2573 7.004e-30 124.0 COG0824@1|root,COG0824@2|Bacteria,1ZV5K@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Thioesterase superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT CMS1_k127_4599498_11 861299.J421_2044 1.866e-30 140.0 2EXVN@1|root,33R4S@2|Bacteria,1ZTD4@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4599498_19 1125863.JAFN01000001_gene26 3.763e-05 52.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS_9,Sigma54_activat CMS1_k127_4599498_0 861299.J421_4433 5.616e-310 972.0 COG1643@1|root,COG1643@2|Bacteria,1ZSN8@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Atp-dependent helicase - - - - - - - - - - - - - CMS1_k127_4599498_4 357808.RoseRS_1829 2.578e-143 463.0 COG0205@1|root,COG0205@2|Bacteria,2G6CJ@200795|Chloroflexi,374WW@32061|Chloroflexia 32061|Chloroflexia F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK CMS1_k127_4599498_18 997346.HMPREF9374_0031 2.245e-08 57.0 COG3526@1|root,COG3526@2|Bacteria,1VKFI@1239|Firmicutes,4HR9S@91061|Bacilli 91061|Bacilli O Rdx family - - - ko:K07401 - - - - ko00000 - - - Rdx CMS1_k127_4599498_14 1120973.AQXL01000132_gene2258 6.613e-21 109.0 COG0840@1|root,COG0840@2|Bacteria,1UZVD@1239|Firmicutes,4HECG@91061|Bacilli 91061|Bacilli NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal CMS1_k127_4599498_20 8049.ENSGMOP00000009456 6.22e-05 56.0 KOG4441@1|root,KOG4441@2759|Eukaryota,39PFQ@33154|Opisthokonta,3BJW6@33208|Metazoa,3CUSE@33213|Bilateria,48DG1@7711|Chordata,499RY@7742|Vertebrata,4A29H@7898|Actinopterygii 33208|Metazoa T Si ch211-256e16.3 - - - ko:K10457,ko:K10461 - - - - ko00000,ko04121 - - - BACK,BTB,Kelch_1 CMS1_k127_4599498_2 861299.J421_1696 1.064e-247 787.0 COG2866@1|root,COG2866@2|Bacteria,1ZUNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS1_k127_4599498_7 717605.Theco_3656 5.262e-80 284.0 COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,4HAPK@91061|Bacilli,26V88@186822|Paenibacillaceae 91061|Bacilli S Putative glycosyl hydrolase domain - - - - - - - - - - - - DUF4015 CMS1_k127_4599498_9 1125863.JAFN01000001_gene341 1.769e-63 228.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo CMS1_k127_4599498_8 861299.J421_2212 3.235e-73 250.0 COG0742@1|root,COG0742@2|Bacteria,1ZTNJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Conserved hypothetical protein 95 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 CMS1_k127_4599498_10 1379270.AUXF01000002_gene1587 3.049e-41 156.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1587|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4604561_0 1550073.JROH01000001_gene721 1.754e-227 733.0 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2U0Q9@28211|Alphaproteobacteria,2K0JA@204457|Sphingomonadales 1224|Proteobacteria G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N CMS1_k127_460740_0 357808.RoseRS_4327 9.313e-27 126.0 COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi,375BC@32061|Chloroflexia 32061|Chloroflexia K transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_8 CMS1_k127_460740_1 67257.JODR01000017_gene4471 2.298e-08 62.0 COG2362@1|root,COG2362@2|Bacteria,2GK6A@201174|Actinobacteria 201174|Actinobacteria E D-aminopeptidase - - - ko:K16203 - - - - ko00000,ko01000,ko01002 3.A.1.5.2 - - Peptidase_M55 CMS1_k127_4609360_8 1499967.BAYZ01000036_gene2419 2.797e-27 127.0 COG2152@1|root,COG2152@2|Bacteria,2NPB8@2323|unclassified Bacteria 2|Bacteria G beta-1,4-mannooligosaccharide phosphorylase - - - - - - - - - - - - Glyco_hydro_130 CMS1_k127_4609360_0 518766.Rmar_1363 1.818e-274 865.0 COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes 976|Bacteroidetes M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_4609360_3 314230.DSM3645_27723 1.247e-76 265.0 COG3752@1|root,COG3752@2|Bacteria,2IZ0I@203682|Planctomycetes 203682|Planctomycetes S 3-oxo-5-alpha-steroid 4-dehydrogenase - - - - - - - - - - - - DUF1295 CMS1_k127_4609360_4 458817.Shal_0355 2.185e-71 262.0 COG1495@1|root,COG1495@2|Bacteria,1R9CU@1224|Proteobacteria,1S3F9@1236|Gammaproteobacteria,2QB9S@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM Disulphide bond formation protein DsbB - - - - - - - - - - - - DsbB CMS1_k127_4609360_9 698964.CDPW8_2030 7.225e-06 49.0 2AS7H@1|root,31HKI@2|Bacteria,2HM72@201174|Actinobacteria,22P8W@1653|Corynebacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_4609360_7 706587.Desti_1672 2.633e-33 149.0 COG0432@1|root,COG0432@2|Bacteria,1N5SN@1224|Proteobacteria,42SJC@68525|delta/epsilon subdivisions,2WP9F@28221|Deltaproteobacteria,2MRXI@213462|Syntrophobacterales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 CMS1_k127_4609360_6 1121124.JNIX01000001_gene1006 9.4e-59 220.0 COG2382@1|root,COG2382@2|Bacteria,1QZM0@1224|Proteobacteria,2TY9P@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Putative esterase - - - - - - - - - - - - Esterase CMS1_k127_4609360_1 1048983.EL17_01845 8.028e-211 672.0 COG0366@1|root,COG0366@2|Bacteria,4PIQV@976|Bacteroidetes,47TNQ@768503|Cytophagia 976|Bacteroidetes G Alpha amylase, catalytic domain - - - - - - - - - - - - Alpha-amylase CMS1_k127_4609360_2 452637.Oter_1883 7.37e-132 451.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_4609360_5 518766.Rmar_0489 1.092e-67 237.0 COG3934@1|root,COG3934@2|Bacteria,4NFVS@976|Bacteroidetes 976|Bacteroidetes G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - - - - - - - - - - Cellulase CMS1_k127_4618243_8 861299.J421_4225 4.561e-76 268.0 COG1141@1|root,COG1752@1|root,COG1141@2|Bacteria,COG1752@2|Bacteria,1ZT7Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S single cluster domain - - - ko:K07001 - - - - ko00000 - - - Fer4_15,Patatin CMS1_k127_4618243_3 861299.J421_2583 1.639e-120 408.0 COG1132@1|root,COG1132@2|Bacteria,1ZT2T@142182|Gemmatimonadetes 142182|Gemmatimonadetes V ABC transporter transmembrane region - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran CMS1_k127_4618243_0 861299.J421_2582 4.975e-198 630.0 COG0745@1|root,COG0745@2|Bacteria,1ZTEW@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT PglZ domain - - - - - - - - - - - - PglZ,Response_reg CMS1_k127_4618243_19 1125863.JAFN01000001_gene536 3.626e-38 166.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42UES@68525|delta/epsilon subdivisions,2WQD1@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM glycosyl transferase family 9 - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 CMS1_k127_4618243_16 379066.GAU_0636 5.667e-45 179.0 COG0305@1|root,COG0305@2|Bacteria,1ZUU3@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_C CMS1_k127_4618243_14 1321778.HMPREF1982_01776 9.377e-61 224.0 COG0697@1|root,COG0697@2|Bacteria,1UZ6C@1239|Firmicutes,24GY3@186801|Clostridia 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_4618243_7 861299.J421_2581 8.258e-92 309.0 COG0217@1|root,COG0217@2|Bacteria,1ZTF4@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulator - - - - - - - - - - - - Transcrip_reg CMS1_k127_4618243_15 1379270.AUXF01000004_gene3248 7.555e-48 180.0 COG0817@1|root,COG0817@2|Bacteria,1ZTKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC CMS1_k127_4618243_17 1379270.AUXF01000004_gene3249 2.184e-43 169.0 COG0632@1|root,COG0632@2|Bacteria,1ZTR0@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N CMS1_k127_4618243_1 379066.GAU_0629 4.918e-151 486.0 COG2255@1|root,COG2255@2|Bacteria,1ZT9W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N CMS1_k127_4618243_11 1379270.AUXF01000004_gene3255 1.123e-65 250.0 COG0457@1|root,COG0457@2|Bacteria 1379270.AUXF01000004_gene3255|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_4618243_13 1379270.AUXF01000004_gene3255 7.147e-65 253.0 COG0457@1|root,COG0457@2|Bacteria 1379270.AUXF01000004_gene3255|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_4618243_4 861299.J421_2570 4.594e-113 377.0 COG0809@1|root,COG0809@2|Bacteria,1ZSV2@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth CMS1_k127_4618243_2 861299.J421_2569 3.54e-143 464.0 COG0343@1|root,COG0343@2|Bacteria,1ZSRS@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) - - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT CMS1_k127_4618243_22 861299.J421_2568 3.983e-16 85.0 COG1862@1|root,COG1862@2|Bacteria,1ZU5F@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Preprotein translocase subunit - - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC CMS1_k127_4618243_20 379066.GAU_0625 2.549e-35 147.0 COG0242@1|root,COG0242@2|Bacteria,1ZTPP@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase CMS1_k127_4618243_5 861299.J421_2566 8.201e-104 355.0 COG0223@1|root,COG0223@2|Bacteria,1ZTE5@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N CMS1_k127_4618243_21 404589.Anae109_1348 4.773e-27 127.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42NTP@68525|delta/epsilon subdivisions,2WQME@28221|Deltaproteobacteria,2YVSW@29|Myxococcales 28221|Deltaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) tenI GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI CMS1_k127_4618243_24 1217720.ALOX01000053_gene1616 7.412e-14 83.0 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2UG5I@28211|Alphaproteobacteria 28211|Alphaproteobacteria H thiamine biosynthesis protein ThiS thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS CMS1_k127_4618243_6 671143.DAMO_2565 1.167e-93 317.0 COG2022@1|root,COG2022@2|Bacteria,2NQHA@2323|unclassified Bacteria 2|Bacteria H Thiazole biosynthesis protein ThiG thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG,ThiS CMS1_k127_4618243_9 861299.J421_2565 1.882e-74 276.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1ZTGM@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB CMS1_k127_4618243_23 105420.BBPO01000029_gene6756 2.684e-15 90.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,2NFGQ@228398|Streptacidiphilus 201174|Actinobacteria KLT PASTA pknL GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase CMS1_k127_4618243_10 861299.J421_2563 5.482e-71 264.0 COG0036@1|root,COG0036@2|Bacteria,1ZSP8@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Ribulose-phosphate 3 epimerase family - - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim CMS1_k127_4618243_18 1379270.AUXF01000004_gene3264 1.056e-41 169.0 COG0526@1|root,COG0526@2|Bacteria,1ZTMM@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Glutathione peroxidase - - - - - - - - - - - - AhpC-TSA CMS1_k127_4618243_12 379066.GAU_0619 1.651e-65 228.0 COG0533@1|root,COG0533@2|Bacteria,1ZT0P@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 CMS1_k127_4625173_0 1121920.AUAU01000013_gene1695 0.0 1056.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,3Y2WK@57723|Acidobacteria 57723|Acidobacteria M Tricorn protease homolog - - - - - - - - - - - - PD40,Peptidase_S41,Tricorn_C1 CMS1_k127_4625173_6 861299.J421_2836 1.746e-67 256.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_2836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_4625173_5 1444309.JAQG01000172_gene456 1.659e-77 275.0 COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,4H9RK@91061|Bacilli,26QNT@186822|Paenibacillaceae 91061|Bacilli NU twitching motility protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS1_k127_4625173_7 485913.Krac_9502 5.689e-55 211.0 COG0604@1|root,COG0604@2|Bacteria 2|Bacteria C NADPH:quinone reductase activity fadB5 - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 CMS1_k127_4625173_8 926554.KI912675_gene2318 1.264e-16 91.0 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1WKSF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_12 CMS1_k127_4625173_10 1166018.FAES_1400 7.811e-06 59.0 COG2318@1|root,COG2318@2|Bacteria,4NNRD@976|Bacteroidetes,47PZE@768503|Cytophagia 976|Bacteroidetes S DinB family - - - - - - - - - - - - DinB,DinB_2 CMS1_k127_4625173_2 1210884.HG799464_gene10774 2.601e-181 600.0 COG1228@1|root,COG1228@2|Bacteria,2IYFS@203682|Planctomycetes 203682|Planctomycetes Q COG1228 Imidazolonepropionase and related - - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 CMS1_k127_4625173_4 234267.Acid_6719 1.784e-89 321.0 COG1228@1|root,COG1228@2|Bacteria,3Y6WV@57723|Acidobacteria 57723|Acidobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS1_k127_4625173_3 1442599.JAAN01000018_gene2871 1.6e-139 470.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RT11@1236|Gammaproteobacteria,1XCXH@135614|Xanthomonadales 135614|Xanthomonadales EU X-Pro dipeptidyl-peptidase (S15 family) - - - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_4625173_11 1156937.MFUM_1040002 5.395e-05 55.0 COG0392@1|root,COG0392@2|Bacteria,46YYT@74201|Verrucomicrobia,37GP8@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS1_k127_4625173_9 67267.JNXT01000013_gene79 3.064e-08 67.0 COG0707@1|root,COG0707@2|Bacteria,2GMC7@201174|Actinobacteria 201174|Actinobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) - - - - - - - - - - - - Glyphos_transf CMS1_k127_4625173_1 309807.SRU_2765 5.07e-274 865.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,1FJ4M@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EU Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 CMS1_k127_4635855_3 1123368.AUIS01000001_gene1848 1.216e-06 50.0 28N6F@1|root,2ZBBB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_4635855_4 1047013.AQSP01000068_gene2286 1.602e-05 57.0 COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria 2|Bacteria O NHL repeat - - - - - - - - - - - - DUF5128,NHL,TolB_like CMS1_k127_4635855_2 1379270.AUXF01000002_gene1589 1.808e-10 66.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4635855_0 1379270.AUXF01000002_gene1585 1.286e-174 580.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_4635855_1 450851.PHZ_c2869 2.033e-25 114.0 COG1266@1|root,COG1266@2|Bacteria,1NXKQ@1224|Proteobacteria 1224|Proteobacteria S CAAX protease self-immunity - - - - - - - - - - - - Abi CMS1_k127_4636035_1 246197.MXAN_4244 8.029e-37 146.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M6C@68525|delta/epsilon subdivisions,2WM3G@28221|Deltaproteobacteria,2YV02@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg CMS1_k127_4636035_0 1232410.KI421428_gene1054 4.324e-114 388.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains REC, sigma54 interaction, HTH8 - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_4640222_7 1502852.FG94_03616 1.736e-98 341.0 COG1680@1|root,COG1680@2|Bacteria,1R49D@1224|Proteobacteria,2WCNR@28216|Betaproteobacteria,477YU@75682|Oxalobacteraceae 28216|Betaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_4640222_9 483219.LILAB_19665 2.261e-37 160.0 2ESNI@1|root,33K73@2|Bacteria,1Q2MV@1224|Proteobacteria,4388I@68525|delta/epsilon subdivisions,2X3I7@28221|Deltaproteobacteria,2YW7A@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - DUF2378 CMS1_k127_4640222_3 1297742.A176_00719 1.804e-137 452.0 COG1914@1|root,COG1914@2|Bacteria 2|Bacteria P metal ion transmembrane transporter activity mntH - - - - - - - - - - - Nramp CMS1_k127_4640222_1 1379270.AUXF01000002_gene1600 8.9e-172 572.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4640222_5 204669.Acid345_0636 6.967e-121 404.0 COG0520@1|root,COG0520@2|Bacteria,3Y2SC@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 CMS1_k127_4640222_4 483219.LILAB_10685 3.939e-131 449.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,4345U@68525|delta/epsilon subdivisions,2X20T@28221|Deltaproteobacteria,2YVEZ@29|Myxococcales 28221|Deltaproteobacteria T PAS domain - - - - - - - - - - - - HATPase_c,PAS CMS1_k127_4640222_2 926566.Terro_2393 2.385e-162 522.0 COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia 204432|Acidobacteriia T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_4640222_8 246197.MXAN_7144 3.258e-97 326.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2X429@28221|Deltaproteobacteria,2YY1P@29|Myxococcales 28221|Deltaproteobacteria V ABC transporter - - - - - - - - - - - - ABC_tran CMS1_k127_4640222_0 215803.DB30_8370 3.294e-175 579.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_4640222_6 1297742.A176_06444 1.011e-106 365.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_4650506_0 861299.J421_6030 2.03e-217 688.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes 2|Bacteria O Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ CMS1_k127_4650506_17 1489678.RDMS_03980 0.0001503 54.0 COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria,1WIDK@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - NHL,Pkinase CMS1_k127_4650506_7 246197.MXAN_2631 4.292e-118 399.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,43E81@68525|delta/epsilon subdivisions,2WZZ4@28221|Deltaproteobacteria,2YU4S@29|Myxococcales 28221|Deltaproteobacteria S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_4650506_8 713586.KB900536_gene1207 9.032e-87 299.0 COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,1S2PS@1236|Gammaproteobacteria 1236|Gammaproteobacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU,PEMT CMS1_k127_4650506_10 1267535.KB906767_gene4499 1.379e-51 189.0 COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria,2JJS7@204432|Acidobacteriia 204432|Acidobacteriia K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF CMS1_k127_4650506_4 861299.J421_4366 5.925e-164 563.0 COG1629@1|root,COG4771@2|Bacteria,1ZT7X@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg CMS1_k127_4650506_15 1321779.HMPREF1984_00565 6.069e-14 83.0 2E03A@1|root,32VS4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_4650506_5 1461693.ATO10_09273 2.677e-158 520.0 COG0682@1|root,COG0682@2|Bacteria,1R7B3@1224|Proteobacteria 1224|Proteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - - - - - - - - - - LGT,PAP2_3,PEMT CMS1_k127_4650506_11 861299.J421_2173 3.644e-50 193.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_2173|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_4650506_16 1121377.KB906398_gene2212 1.63e-06 60.0 COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria,1WIDK@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - NHL,Pkinase CMS1_k127_4650506_14 886293.Sinac_3510 1.721e-30 141.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - DUF11,PKD CMS1_k127_4650506_3 1047013.AQSP01000115_gene341 4.766e-190 601.0 COG0673@1|root,COG0673@2|Bacteria,2NQ5E@2323|unclassified Bacteria 2|Bacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS1_k127_4650506_1 518766.Rmar_1744 7.086e-217 680.0 COG0477@1|root,COG2814@2|Bacteria,4PKJD@976|Bacteroidetes 976|Bacteroidetes EGP PFAM nucleoside H symporter - - - - - - - - - - - - Nuc_H_symport CMS1_k127_4650506_2 1047013.AQSP01000115_gene340 3.048e-213 674.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA CMS1_k127_4650506_12 1047013.AQSP01000115_gene339 2.465e-48 178.0 295NE@1|root,2ZSZT@2|Bacteria 2|Bacteria S DoxX - - 1.8.5.2 ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - DoxX CMS1_k127_4650506_9 335543.Sfum_2693 6.277e-71 252.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,2MS09@213462|Syntrophobacterales 28221|Deltaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE CMS1_k127_4650506_6 518766.Rmar_1743 3.919e-119 396.0 COG1082@1|root,COG1082@2|Bacteria,4NG1K@976|Bacteroidetes 976|Bacteroidetes G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 CMS1_k127_4650506_13 929562.Emtol_2946 4.665e-42 157.0 COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,47KZQ@768503|Cytophagia 976|Bacteroidetes J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase CMS1_k127_4650870_7 861299.J421_4495 2.412e-52 205.0 COG4219@1|root,COG4219@2|Bacteria,1ZUY4@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT BlaR1 peptidase M56 - - - - - - - - - - - - Peptidase_M56,TonB_C CMS1_k127_4650870_11 861299.J421_4494 1.323e-27 119.0 COG3682@1|root,COG3682@2|Bacteria,1ZU4Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R CMS1_k127_4650870_0 861299.J421_2006 9.151e-165 557.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUC3@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4650870_9 1321778.HMPREF1982_00647 7.871e-40 171.0 28N78@1|root,2ZBBY@2|Bacteria,1VWWN@1239|Firmicutes,24QA9@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4932) - - - - - - - - - - - - DUF4932 CMS1_k127_4650870_6 1267535.KB906767_gene5044 7.735e-55 202.0 COG4221@1|root,COG4221@2|Bacteria,3Y4DX@57723|Acidobacteria 57723|Acidobacteria S KR domain - - - - - - - - - - - - adh_short CMS1_k127_4650870_15 1122603.ATVI01000005_gene3432 2.29e-09 65.0 2EJ66@1|root,33CXD@2|Bacteria,1NKZ7@1224|Proteobacteria,1SVG7@1236|Gammaproteobacteria,1XBBK@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - CMS1_k127_4650870_5 518766.Rmar_0728 4.089e-61 219.0 COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,1FJ6B@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Glycine zipper - - - - - - - - - - - - Gly-zipper_Omp,OmpA,PD40 CMS1_k127_4650870_14 1185876.BN8_03191 1.597e-12 80.0 COG3238@1|root,COG3238@2|Bacteria,4NQQ3@976|Bacteroidetes,47QPV@768503|Cytophagia 976|Bacteroidetes S Putative inner membrane exporter, YdcZ - - - ko:K09936 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.7.21 - - DMT_YdcZ CMS1_k127_4650870_8 1123393.KB891332_gene2786 2.693e-46 187.0 COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1MZV7@1224|Proteobacteria,2WEG8@28216|Betaproteobacteria,1KS7W@119069|Hydrogenophilales 119069|Hydrogenophilales KT Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GGDEF CMS1_k127_4650870_4 861299.J421_0787 9.006e-78 270.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS1_k127_4650870_10 1223542.GM1_002_00120 7.104e-31 123.0 COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4GEUR@85026|Gordoniaceae 201174|Actinobacteria S Uncharacterized conserved protein (DUF2277) - - - - - - - - - - - - DUF2277 CMS1_k127_4650870_12 234267.Acid_5214 2.522e-20 106.0 COG2318@1|root,COG2318@2|Bacteria,3Y569@57723|Acidobacteria 57723|Acidobacteria S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_4650870_2 861299.J421_1231 1.794e-97 353.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1231|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_4650870_13 1356852.N008_19065 3.805e-19 101.0 28JZK@1|root,2Z9PJ@2|Bacteria,4NIWX@976|Bacteroidetes,47T27@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_4650870_1 1379270.AUXF01000002_gene1586 5.755e-160 537.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4650870_3 1379270.AUXF01000002_gene1586 1.313e-79 289.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4653767_1 330214.NIDE0014 1.136e-124 407.0 COG0655@1|root,COG2146@1|root,COG0655@2|Bacteria,COG2146@2|Bacteria 2|Bacteria P nitrite reductase [NAD(P)H] activity - - 1.2.3.3,1.6.5.2,1.7.1.15 ko:K00158,ko:K00363,ko:K03809,ko:K05710 ko00130,ko00360,ko00620,ko00910,ko01100,ko01110,ko01120,ko01220,map00130,map00360,map00620,map00910,map01100,map01110,map01120,map01220 M00530,M00545 R00207,R00787,R02964,R03643,R03816,R06782,R06783 RC00098,RC00176,RC00819,RC02745 br01602,ko00000,ko00001,ko00002,ko01000 - - - FMN_red,Rieske,TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N CMS1_k127_4653767_0 1124780.ANNU01000036_gene34 3.821e-220 717.0 COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,47M9P@768503|Cytophagia 976|Bacteroidetes E Amino acid permease - - - - - - - - - - - - AA_permease CMS1_k127_4653767_2 675635.Psed_1449 7.25e-64 230.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DXB8@85010|Pseudonocardiales 201174|Actinobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N CMS1_k127_4680095_11 666685.R2APBS1_0672 6.788e-103 354.0 COG0438@1|root,COG0438@2|Bacteria,1PDQY@1224|Proteobacteria,1SE53@1236|Gammaproteobacteria,1X59A@135614|Xanthomonadales 135614|Xanthomonadales M Hexosyltransferase - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_4680095_14 1449076.JOOE01000001_gene3034 1.359e-81 307.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase group 1 treT - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 CMS1_k127_4680095_27 861299.J421_0839 6.972e-44 173.0 COG1493@1|root,COG1493@2|Bacteria 2|Bacteria T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - - - - - - - - - - DRTGG CMS1_k127_4680095_45 926566.Terro_1188 1.456e-10 73.0 COG0477@1|root,COG2814@2|Bacteria,3Y7ZK@57723|Acidobacteria,2JMZ2@204432|Acidobacteriia 204432|Acidobacteriia EGP PFAM Major facilitator superfamily - - - - - - - - - - - - MFS_1 CMS1_k127_4680095_21 671143.DAMO_2083 6.719e-62 245.0 COG4206@1|root,COG4206@2|Bacteria,2NP6H@2323|unclassified Bacteria 2|Bacteria H TonB dependent receptor btuB - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec CMS1_k127_4680095_1 1239962.C943_02113 1.675e-251 807.0 COG1506@1|root,COG1506@2|Bacteria,4NDVD@976|Bacteroidetes,47N2Q@768503|Cytophagia 976|Bacteroidetes E Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 CMS1_k127_4680095_5 861299.J421_4263 3.979e-180 579.0 COG2234@1|root,COG2234@2|Bacteria,1ZT06@142182|Gemmatimonadetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS1_k127_4680095_25 523791.Kkor_2400 6.482e-48 179.0 COG0457@1|root,COG0457@2|Bacteria,1N9D5@1224|Proteobacteria,1SAKR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_4680095_28 204669.Acid345_1922 7.544e-43 169.0 COG2259@1|root,COG2259@2|Bacteria,3Y4XF@57723|Acidobacteria,2JMZV@204432|Acidobacteriia 204432|Acidobacteriia S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX CMS1_k127_4680095_29 1379270.AUXF01000002_gene1799 3.092e-41 159.0 COG1846@1|root,COG1846@2|Bacteria,1ZU5M@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR CMS1_k127_4680095_42 1219035.NT2_11_00380 1.084e-16 87.0 COG2010@1|root,COG2010@2|Bacteria,1N7I9@1224|Proteobacteria,2V1R3@28211|Alphaproteobacteria,2KBX4@204457|Sphingomonadales 204457|Sphingomonadales C Cytochrome c - - - - - - - - - - - - - CMS1_k127_4680095_18 1122604.JONR01000007_gene2936 1.174e-70 259.0 28P4Q@1|root,2ZBZV@2|Bacteria,1RA48@1224|Proteobacteria,1S347@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_4680095_9 1519464.HY22_06470 1.051e-122 409.0 COG1473@1|root,COG1473@2|Bacteria,1FDR4@1090|Chlorobi 2|Bacteria S peptidase dimerisation domain protein - - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 CMS1_k127_4680095_19 1390370.O203_05325 1.517e-70 251.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1YDFT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex CMS1_k127_4680095_17 518766.Rmar_0540 5.134e-74 257.0 COG2755@1|root,COG2755@2|Bacteria,4NE58@976|Bacteroidetes,1FJCB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase family tesA - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 CMS1_k127_4680095_13 379066.GAU_2113 3.708e-84 286.0 COG4181@1|root,COG4181@2|Bacteria,1ZUJS@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_4680095_4 379066.GAU_2114 3.02e-197 653.0 COG3127@1|root,COG3127@2|Bacteria,1ZT3A@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_4680095_0 1379270.AUXF01000001_gene2749 3.906e-299 930.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZSXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes EU Acetyl xylan esterase (AXE1) - - - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_4680095_26 861299.J421_2069 2.14e-45 170.0 COG0234@1|root,COG0234@2|Bacteria,1ZU6V@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - - - - - - - - - - Cpn10 CMS1_k127_4680095_7 379066.GAU_0793 1.512e-164 534.0 COG0213@1|root,COG0213@2|Bacteria,1ZTBE@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Pyrimidine nucleoside phosphorylase C-terminal domain - - 2.4.2.2 ko:K00756 ko00240,ko01100,map00240,map01100 - R01570,R01876,R02296,R02484 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C CMS1_k127_4680095_32 379066.GAU_0792 5.89e-38 154.0 COG0457@1|root,COG0457@2|Bacteria,1ZTR4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_4680095_46 1232410.KI421421_gene3359 0.0003244 48.0 COG4980@1|root,COG4980@2|Bacteria,1NEPD@1224|Proteobacteria,42WE2@68525|delta/epsilon subdivisions,2WRDT@28221|Deltaproteobacteria,43SRZ@69541|Desulfuromonadales 28221|Deltaproteobacteria S YtxH-like protein - - - - - - - - - - - - YtxH CMS1_k127_4680095_38 1242864.D187_002804 1.301e-23 110.0 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,4304I@68525|delta/epsilon subdivisions,2WVDN@28221|Deltaproteobacteria 28221|Deltaproteobacteria T sensor histidine kinase response - - - - - - - - - - - - GAF,GGDEF,HATPase_c,HisKA,Response_reg CMS1_k127_4680095_41 1379270.AUXF01000004_gene3089 4.245e-17 95.0 COG1719@1|root,COG1719@2|Bacteria,1ZU65@142182|Gemmatimonadetes 142182|Gemmatimonadetes S 4-vinyl reductase, 4VR - - - - - - - - - - - - - CMS1_k127_4680095_24 861299.J421_2712 9.851e-49 179.0 COG2236@1|root,COG2236@2|Bacteria,1ZTQ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Phosphoribosyl transferase domain - - - ko:K07101 - - - - ko00000 - - - Pribosyltran CMS1_k127_4680095_22 861299.J421_2711 2.924e-51 185.0 COG0457@1|root,COG0457@2|Bacteria,1ZTX0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11 CMS1_k127_4680095_3 1379270.AUXF01000004_gene3094 4.688e-212 675.0 COG1022@1|root,COG1022@2|Bacteria,1ZT60@142182|Gemmatimonadetes 142182|Gemmatimonadetes I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding CMS1_k127_4680095_40 861299.J421_2706 9.26e-21 100.0 2FCPE@1|root,344SN@2|Bacteria,1ZU2F@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4680095_43 290397.Adeh_0752 1.733e-13 85.0 COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,42S5S@68525|delta/epsilon subdivisions,2WNSS@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Lysin motif - - - ko:K06194 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 CMS1_k127_4680095_47 522373.Smlt1542 0.0005146 53.0 COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R9NB@1224|Proteobacteria,1S1MC@1236|Gammaproteobacteria,1XCAK@135614|Xanthomonadales 135614|Xanthomonadales T Two component regulator propeller - - - - - - - - - - - - GGDEF,Reg_prop,Y_Y_Y CMS1_k127_4680095_20 861299.J421_2705 3.421e-63 230.0 COG4221@1|root,COG4221@2|Bacteria,1ZTPW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S KR domain - - - - - - - - - - - - adh_short CMS1_k127_4680095_16 1379270.AUXF01000004_gene3097 1.596e-80 276.0 COG0302@1|root,COG0302@2|Bacteria,1ZT6I@142182|Gemmatimonadetes 142182|Gemmatimonadetes H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI CMS1_k127_4680095_39 1128421.JAGA01000002_gene653 5.64e-21 98.0 2E5G6@1|root,3307V@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - SseB CMS1_k127_4680095_33 1282876.BAOK01000002_gene841 8.211e-37 156.0 COG1228@1|root,COG1228@2|Bacteria,1R40Z@1224|Proteobacteria,2U85Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q amidohydrolase - - - - - - - - - - - - Amidohydro_1 CMS1_k127_4680095_36 1122185.N792_09720 3.476e-25 116.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1SWYN@1236|Gammaproteobacteria,1X8Q4@135614|Xanthomonadales 135614|Xanthomonadales D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB CMS1_k127_4680095_30 880073.Calab_0541 1.669e-40 156.0 COG1993@1|root,COG1993@2|Bacteria,2NPXF@2323|unclassified Bacteria 2|Bacteria T Uncharacterized ACR, COG1993 - - - ko:K06199,ko:K09137 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CBS,DUF190 CMS1_k127_4680095_12 1379270.AUXF01000004_gene3100 4.595e-98 333.0 COG0454@1|root,COG0454@2|Bacteria,1ZSVU@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_4680095_6 861299.J421_2697 2.018e-168 571.0 COG0419@1|root,COG0419@2|Bacteria,1ZTD9@142182|Gemmatimonadetes 142182|Gemmatimonadetes L AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - SMC_N CMS1_k127_4680095_10 1379270.AUXF01000004_gene3102 1.761e-109 369.0 COG0420@1|root,COG0420@2|Bacteria,1ZSPE@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Calcineurin-like phosphoesterase superfamily domain - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos CMS1_k127_4680095_2 1379270.AUXF01000004_gene3104 2.929e-237 753.0 COG0433@1|root,COG0433@2|Bacteria,1ZURZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S COG0433 Predicted ATPase - - - ko:K06915 - - - - ko00000 - - - - CMS1_k127_4680095_35 861299.J421_2693 5.608e-27 128.0 COG2380@1|root,COG2380@2|Bacteria,1ZUZS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S COGs COG2380 conserved - - - - - - - - - - - - - CMS1_k127_4680095_23 663610.JQKO01000010_gene2233 5.98e-49 189.0 COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,2U6AD@28211|Alphaproteobacteria,3NAPF@45404|Beijerinckiaceae 28211|Alphaproteobacteria S O-methyltransferase mdmC - - - - - - - - - - - Methyltransf_3 CMS1_k127_4680095_15 1157637.KB892096_gene1026 4.568e-81 285.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria 201174|Actinobacteria E Aminotransferase aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_4680095_8 204669.Acid345_0995 9.68e-130 428.0 COG3191@1|root,COG3191@2|Bacteria,3Y699@57723|Acidobacteria 57723|Acidobacteria M Peptidase family S58 - - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 CMS1_k127_4680095_34 861299.J421_2689 1.801e-30 139.0 COG0513@1|root,COG0513@2|Bacteria,1ZTQP@142182|Gemmatimonadetes 142182|Gemmatimonadetes JKL DbpA RNA binding domain - - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DbpA CMS1_k127_4680095_37 765914.ThisiDRAFT_0762 3.91e-24 105.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS1_k127_4680095_31 861299.J421_2688 3.413e-38 148.0 COG1435@1|root,COG1435@2|Bacteria,1ZTB2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Thymidine kinase tdk - 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK CMS1_k127_4706652_16 1379698.RBG1_1C00001G1369 2.58e-26 123.0 COG4219@1|root,COG4219@2|Bacteria,2NR11@2323|unclassified Bacteria 2|Bacteria KT Peptidase M56 - - - - - - - - - - - - Amidase_6,DUF4309,DUF5301 CMS1_k127_4706652_5 391625.PPSIR1_22374 9.698e-168 540.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,42MGQ@68525|delta/epsilon subdivisions,2WSUN@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM amino acid permease-associated region - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS1_k127_4706652_8 861299.J421_0689 1.451e-83 299.0 COG0795@1|root,COG0795@2|Bacteria,1ZSNM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Predicted permease YjgP/YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ CMS1_k127_4706652_7 861299.J421_4162 9.824e-89 311.0 COG0795@1|root,COG0795@2|Bacteria,1ZTJR@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Predicted permease YjgP/YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ CMS1_k127_4706652_0 1379270.AUXF01000001_gene2822 0.0 1069.0 COG4797@1|root,COG4797@2|Bacteria 2|Bacteria - - - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259 - - - - - - - - - - Glyco_transf_41,MethyTransf_Reg,Methyltransf_12,Methyltransf_25,Methyltransf_31 CMS1_k127_4706652_11 1379698.RBG1_1C00001G0436 1.479e-63 245.0 COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria 2|Bacteria S Peptidase M28 ywaD - - - - - - - - - - - Peptidase_M28 CMS1_k127_4706652_17 861299.J421_4159 3.26e-13 78.0 COG1555@1|root,COG1555@2|Bacteria,1ZV96@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Helix-hairpin-helix motif - - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 CMS1_k127_4706652_18 717605.Theco_2419 4.115e-11 72.0 COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,4HKJ1@91061|Bacilli,26X94@186822|Paenibacillaceae 91061|Bacilli L DNA uptake protein and related DNA-binding proteins comEA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB CMS1_k127_4706652_1 639282.DEFDS_1109 2.387e-190 610.0 COG2804@1|root,COG2804@2|Bacteria,2GEP7@200930|Deferribacteres 200930|Deferribacteres NU General secretory system II protein E domain protein - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N CMS1_k127_4706652_3 861299.J421_4157 2.136e-183 588.0 COG2805@1|root,COG2805@2|Bacteria,1ZSQE@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS1_k127_4706652_4 1379270.AUXF01000001_gene2826 5.896e-173 550.0 COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Type II secretion system (T2SS), protein F - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF CMS1_k127_4706652_15 292459.STH2474 1.79e-29 126.0 COG1266@1|root,COG1266@2|Bacteria,1VHVC@1239|Firmicutes 1239|Firmicutes V CAAX protease self-immunity - - - - - - - - - - - - Abi CMS1_k127_4706652_13 861299.J421_1222 1.653e-39 150.0 COG1393@1|root,COG1393@2|Bacteria,1ZTUV@142182|Gemmatimonadetes 142182|Gemmatimonadetes P ArsC family - - - - - - - - - - - - ArsC CMS1_k127_4706652_10 118005.AWNK01000010_gene405 1.539e-65 237.0 COG0652@1|root,COG0652@2|Bacteria 2|Bacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase CMS1_k127_4706652_14 1380370.JIBA01000002_gene2622 1.093e-37 153.0 COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria,4FH2S@85021|Intrasporangiaceae 201174|Actinobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP CMS1_k127_4706652_6 1379270.AUXF01000003_gene3385 8.389e-119 402.0 COG3852@1|root,COG3852@2|Bacteria,1ZSYP@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PAS domain - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA CMS1_k127_4706652_2 379066.GAU_2525 1.21e-184 598.0 COG2204@1|root,COG2204@2|Bacteria,1ZSRQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_4706652_12 984262.SGRA_2778 5.013e-49 184.0 COG2227@1|root,COG2227@2|Bacteria,4NJXV@976|Bacteroidetes 976|Bacteroidetes H AdoMet dependent proline di-methyltransferase - - - - - - - - - - - - Methyltransf_12,Methyltransf_23 CMS1_k127_4706652_9 596151.DesfrDRAFT_3479 4.495e-77 271.0 COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2M9BR@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,GtrA CMS1_k127_4712487_0 1047013.AQSP01000126_gene2740 8.044e-196 623.0 COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria 2|Bacteria E Zinc carboxypeptidase - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS1_k127_4727170_0 1122613.ATUP01000001_gene1143 2.015e-170 548.0 COG2234@1|root,COG2234@2|Bacteria,1MWBX@1224|Proteobacteria,2U2RE@28211|Alphaproteobacteria,43X5T@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Fibronectin type 3 domain - - - - - - - - - - - - Peptidase_M28 CMS1_k127_4727170_1 1449347.JQLN01000004_gene7159 1.393e-23 103.0 COG0515@1|root,COG0515@2|Bacteria,2I9TD@201174|Actinobacteria,2M0HA@2063|Kitasatospora 201174|Actinobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4727171_2 1122182.KB903838_gene4065 3.762e-23 102.0 COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4DAUE@85008|Micromonosporales 201174|Actinobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4727171_3 1173027.Mic7113_1503 1.181e-21 111.0 COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1G04W@1117|Cyanobacteria,1H940@1150|Oscillatoriales 1117|Cyanobacteria O Peptidase S8 and S53 subtilisin kexin sedolisin - - - - - - - - - - - - P_proprotein,Peptidase_S8,SLH CMS1_k127_4727171_0 861299.J421_4135 1.358e-83 310.0 COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4727171_1 861299.J421_4449 1.852e-77 285.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4749807_9 1379270.AUXF01000002_gene1600 1.415e-51 189.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_4749807_3 861299.J421_4211 2.767e-125 411.0 COG0457@1|root,COG0457@2|Bacteria,1ZSYB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2 CMS1_k127_4749807_2 861299.J421_4207 1.599e-163 546.0 COG0612@1|root,COG0612@2|Bacteria,1ZSU0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS1_k127_4749807_15 215803.DB30_7168 3.969e-39 152.0 COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42UGQ@68525|delta/epsilon subdivisions,2WQY8@28221|Deltaproteobacteria,2YVI9@29|Myxococcales 28221|Deltaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding CMS1_k127_4749807_23 269796.Rru_A2221 9.854e-10 66.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria,2JRVC@204441|Rhodospirillales 204441|Rhodospirillales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf CMS1_k127_4749807_19 1345697.M493_09125 1.198e-22 109.0 COG1765@1|root,COG1765@2|Bacteria,1V7SN@1239|Firmicutes,4HIEM@91061|Bacilli,1WFEG@129337|Geobacillus 91061|Bacilli O OsmC-like protein yhfA - - ko:K07397 - - - - ko00000 - - - OsmC CMS1_k127_4749807_21 861299.J421_4201 1.624e-15 80.0 2CA00@1|root,344QM@2|Bacteria,1ZU1Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4749807_12 1379270.AUXF01000001_gene2790 8.396e-44 170.0 COG1651@1|root,COG1651@2|Bacteria,1ZTKP@142182|Gemmatimonadetes 142182|Gemmatimonadetes O DSBA-like thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 CMS1_k127_4749807_20 1379270.AUXF01000005_gene466 2.396e-20 103.0 COG4243@1|root,COG4243@2|Bacteria,1ZTVC@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Vitamin K epoxide reductase family - - - - - - - - - - - - VKOR CMS1_k127_4749807_0 861299.J421_4196 4.4e-322 996.0 COG0365@1|root,COG0365@2|Bacteria,1ZSUU@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS1_k127_4749807_13 485913.Krac_8610 8.555e-43 169.0 COG1131@1|root,COG1131@2|Bacteria,2G6IS@200795|Chloroflexi 200795|Chloroflexi V PFAM ABC transporter related ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran CMS1_k127_4749807_7 861299.J421_4191 6.238e-58 219.0 COG2386@1|root,COG2386@2|Bacteria,1ZTJ6@142182|Gemmatimonadetes 142182|Gemmatimonadetes O CcmB protein - - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB CMS1_k127_4749807_6 861299.J421_4190 3.211e-70 245.0 COG0755@1|root,COG0755@2|Bacteria,1ZTJG@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome C assembly protein - - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm CMS1_k127_4749807_8 485913.Krac_11442 1.373e-56 207.0 COG0580@1|root,COG0580@2|Bacteria 2|Bacteria U water channel activity glpF - - ko:K02440,ko:K06188,ko:K09874 - - - - ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.12,1.A.8.2 - - MIP CMS1_k127_4749807_1 861299.J421_4185 1.028e-167 538.0 COG0304@1|root,COG0304@2|Bacteria,1ZTE1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt CMS1_k127_4749807_10 861299.J421_4184 1.172e-48 178.0 COG2867@1|root,COG2867@2|Bacteria,1ZTVW@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc CMS1_k127_4749807_14 1379270.AUXF01000001_gene2803 7.577e-40 166.0 COG0500@1|root,COG2226@2|Bacteria,1ZTP4@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 CMS1_k127_4749807_16 272560.BPSL1645 6.711e-32 137.0 COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2VXJR@28216|Betaproteobacteria,1K3SI@119060|Burkholderiaceae 28216|Betaproteobacteria K Flavin reductase - - - - - - - - - - - - Flavin_Reduct CMS1_k127_4749807_5 861299.J421_4181 5.302e-80 282.0 COG0644@1|root,COG0644@2|Bacteria,1ZTEM@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Glucose inhibited division protein A - - 1.3.99.38 ko:K21401 - - - - ko00000,ko01000 - - - FAD_binding_3 CMS1_k127_4749807_17 265729.GS18_0211320 5.073e-31 135.0 COG1836@1|root,COG1836@2|Bacteria,1V7I1@1239|Firmicutes,4HD4D@91061|Bacilli,1ZGQ0@1386|Bacillus 91061|Bacilli S Integral membrane protein DUF92 - - - - - - - - - - - - DUF92 CMS1_k127_4749807_24 1306174.JODP01000006_gene3805 2.264e-08 59.0 COG5662@1|root,COG5662@2|Bacteria 2|Bacteria K AntiSigma factor rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - - - - - - - - - - zf-HC2 CMS1_k127_4749807_11 1379270.AUXF01000001_gene2568 1.281e-48 181.0 COG1595@1|root,COG1595@2|Bacteria,1ZV3I@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_4749807_18 379066.GAU_2585 2.626e-24 116.0 2C9AX@1|root,33WUH@2|Bacteria,1ZTQK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4749807_4 861299.J421_4178 8.328e-108 362.0 COG0006@1|root,COG0006@2|Bacteria,1ZSPF@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Metallopeptidase family M24 - - - - - - - - - - - - Peptidase_M24 CMS1_k127_4781173_1 714943.Mucpa_7051 2.238e-304 951.0 2CDRA@1|root,2Z7QN@2|Bacteria,4NHVB@976|Bacteroidetes,1IQJV@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_4781173_6 1303518.CCALI_00711 1.227e-66 245.0 COG4952@1|root,COG4952@2|Bacteria 2|Bacteria M isomerase activity xylA_2 - 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - AP_endonuc_2 CMS1_k127_4781173_3 278957.ABEA03000120_gene1170 1.826e-215 682.0 COG1069@1|root,COG1069@2|Bacteria,46UI3@74201|Verrucomicrobia,3K769@414999|Opitutae 414999|Opitutae G FGGY family of carbohydrate kinases, C-terminal domain - - 2.7.1.16 ko:K00853 ko00040,ko01100,map00040,map01100 - R01526,R02439 RC00002,RC00538 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N CMS1_k127_4781173_5 518766.Rmar_0470 1.809e-74 277.0 COG0235@1|root,COG0235@2|Bacteria,4NGMP@976|Bacteroidetes 976|Bacteroidetes G Pfam Class II Aldolase and Adducin N-terminal domain araD - 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II CMS1_k127_4781173_2 1191523.MROS_0031 7.669e-271 844.0 COG4146@1|root,COG4146@2|Bacteria 2|Bacteria S symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS1_k127_4781173_7 1128421.JAGA01000002_gene974 3.713e-63 225.0 COG0637@1|root,COG0637@2|Bacteria,2NPXK@2323|unclassified Bacteria 2|Bacteria S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - 5.4.2.6 ko:K01838 ko00500,map00500 - R02728,R11310 RC00408 ko00000,ko00001,ko01000 - - - HAD_2 CMS1_k127_4781173_4 1396141.BATP01000023_gene619 3.117e-110 377.0 COG1070@1|root,COG1070@2|Bacteria,46UPD@74201|Verrucomicrobia,2IV4A@203494|Verrucomicrobiae 203494|Verrucomicrobiae G FGGY family of carbohydrate kinases, C-terminal domain - - - - - - - - - - - - FGGY_C,FGGY_N CMS1_k127_4781173_0 861299.J421_3137 0.0 1165.0 COG0542@1|root,COG0542@2|Bacteria,1ZT9Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N CMS1_k127_4781173_8 1353537.TP2_15200 4.681e-15 82.0 COG4319@1|root,COG4319@2|Bacteria,1RF3Q@1224|Proteobacteria,2U78H@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS1_k127_4815312_0 861299.J421_3420 1.228e-274 856.0 COG0539@1|root,COG0539@2|Bacteria,1ZSKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 CMS1_k127_4815312_2 1075090.GOAMR_14_00150 3.161e-39 163.0 COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4GCWB@85026|Gordoniaceae 201174|Actinobacteria F Cytidylate kinase cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin CMS1_k127_4815312_1 861299.J421_3422 1.19e-101 346.0 COG0128@1|root,COG0128@2|Bacteria 2|Bacteria E 3-phosphoshikimate 1-carboxyvinyltransferase activity aroA GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_0998,iECNA114_1301.ECNA114_0940,iECSF_1327.ECSF_0829,iPC815.YPO1390 EPSP_synthase CMS1_k127_4815312_6 34007.IT40_21560 2.431e-18 95.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria,2PV3Y@265|Paracoccus 28211|Alphaproteobacteria E Dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate tyrC GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH CMS1_k127_4815312_5 215803.DB30_7817 1.197e-22 107.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,42NFH@68525|delta/epsilon subdivisions,2WITT@28221|Deltaproteobacteria,2YX46@29|Myxococcales 28221|Deltaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_4815312_4 861299.J421_5794 1.718e-27 128.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS1_k127_4815312_3 497964.CfE428DRAFT_5961 1.143e-35 149.0 COG2931@1|root,COG3210@1|root,COG4932@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K13735,ko:K15125,ko:K20276 ko02024,ko05100,ko05133,map02024,map05100,map05133 - - - ko00000,ko00001,ko00536 - - - Big_3_2,DUF11,HemolysinCabind CMS1_k127_4821026_4 861299.J421_2796 2.668e-69 243.0 COG0024@1|root,COG0024@2|Bacteria,1ZTC1@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Metallopeptidase family M24 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 CMS1_k127_4821026_9 935567.JAES01000002_gene619 1.108e-54 198.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1X668@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK CMS1_k127_4821026_0 861299.J421_2794 5.058e-171 548.0 COG0201@1|root,COG0201@2|Bacteria,1ZSYZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY CMS1_k127_4821026_10 1379270.AUXF01000004_gene3013 6.82e-41 156.0 COG0200@1|root,COG0200@2|Bacteria,1ZTP0@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A CMS1_k127_4821026_17 861299.J421_2792 2.333e-14 76.0 COG1841@1|root,COG1841@2|Bacteria,1ZU4E@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L30p/L7e - - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 CMS1_k127_4821026_5 379066.GAU_0890 4.124e-67 237.0 COG0098@1|root,COG0098@2|Bacteria,1ZTHD@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C CMS1_k127_4821026_6 861299.J421_2789 1.006e-65 228.0 COG0097@1|root,COG0097@2|Bacteria,1ZTJ8@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 CMS1_k127_4821026_11 877414.ATWA01000001_gene866 5.112e-40 152.0 COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,2696T@186813|unclassified Clostridiales 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 CMS1_k127_4821026_16 335543.Sfum_1568 2.319e-22 97.0 COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2WR7W@28221|Deltaproteobacteria,2MS3E@213462|Syntrophobacterales 28221|Deltaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 CMS1_k127_4821026_3 861299.J421_2786 7.564e-80 271.0 COG0094@1|root,COG0094@2|Bacteria,1ZSTZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C CMS1_k127_4821026_14 1379270.AUXF01000004_gene3022 1.107e-30 130.0 COG0198@1|root,COG0198@2|Bacteria,1ZTRE@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 CMS1_k127_4821026_8 31964.CMS0293 4.019e-58 207.0 COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4FNQS@85023|Microbacteriaceae 201174|Actinobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 CMS1_k127_4821026_15 861299.J421_2783 7.504e-23 104.0 COG0186@1|root,COG0186@2|Bacteria,1ZU1B@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 CMS1_k127_4821026_7 243231.GSU2850 9.555e-60 209.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2WP71@28221|Deltaproteobacteria,43UND@69541|Desulfuromonadales 28221|Deltaproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 CMS1_k127_4821026_1 861299.J421_2780 8.411e-106 353.0 COG0092@1|root,COG0092@2|Bacteria,1ZTFT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C CMS1_k127_4821026_13 1379270.AUXF01000004_gene3028 5.835e-34 138.0 COG0091@1|root,COG0091@2|Bacteria,1ZTVF@142182|Gemmatimonadetes 142182|Gemmatimonadetes J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 CMS1_k127_4821026_12 1191523.MROS_0212 2.681e-38 145.0 COG0185@1|root,COG0185@2|Bacteria 2|Bacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 CMS1_k127_4821026_2 861299.J421_2777 8.103e-104 342.0 COG0090@1|root,COG0090@2|Bacteria,1ZSUP@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C CMS1_k127_4847524_0 861299.J421_0670 2.759e-127 414.0 COG0412@1|root,COG0412@2|Bacteria,1ZT96@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH CMS1_k127_4847524_7 1047013.AQSP01000006_gene2205 2.636e-06 59.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128 CMS1_k127_4847524_4 1101190.ARWB01000001_gene2672 7.288e-79 273.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,3700Y@31993|Methylocystaceae 28211|Alphaproteobacteria C FMN-dependent dehydrogenase - - 1.1.2.3,1.1.3.46,1.13.12.4 ko:K00101,ko:K00467,ko:K16422 ko00261,ko00620,ko01055,ko01100,ko01130,map00261,map00620,map01055,map01100,map01130 - R00196,R00319,R06633 RC00044,RC00240,RC01312 ko00000,ko00001,ko01000 - - - FMN_dh CMS1_k127_4847524_6 1123242.JH636435_gene799 1.827e-07 59.0 COG1574@1|root,COG1574@2|Bacteria,2IX0K@203682|Planctomycetes 203682|Planctomycetes S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 CMS1_k127_4847524_5 1379270.AUXF01000002_gene1577 1.598e-64 253.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4847524_3 861299.J421_5896 3.183e-101 370.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_5896|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_4847524_2 861299.J421_4478 1.073e-112 408.0 COG1574@1|root,COG1574@2|Bacteria,1ZU9S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 CMS1_k127_4847524_1 861299.J421_0887 1.52e-123 433.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4852928_2 861299.J421_1342 9.638e-120 398.0 COG2207@1|root,COG2207@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - HTH_18 CMS1_k127_4852928_8 932678.THERU_04040 2.332e-05 57.0 COG2755@1|root,COG2755@2|Bacteria 2|Bacteria E lipolytic protein G-D-S-L family - - - - - - - - - - - - Lipase_GDSL_2 CMS1_k127_4852928_6 706587.Desti_4837 3.343e-25 121.0 COG2755@1|root,COG2755@2|Bacteria,1R1JV@1224|Proteobacteria 1224|Proteobacteria E lipolytic protein G-D-S-L family - - - - - - - - - - - - - CMS1_k127_4852928_5 1116472.MGMO_72c00090 6.201e-40 171.0 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1XFH2@135618|Methylococcales 135618|Methylococcales P TonB dependent receptor - - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec CMS1_k127_4852928_1 861299.J421_2100 4.384e-158 516.0 COG1524@1|root,COG1524@2|Bacteria,1ZUMA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest CMS1_k127_4852928_7 686578.AFFX01000001_gene1522 1.453e-15 82.0 COG2388@1|root,COG2388@2|Bacteria,1N316@1224|Proteobacteria,1S7D3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S acetyltransferase HA62_12640 - - ko:K06975 - - - - ko00000 - - - Acetyltransf_CG CMS1_k127_4852928_0 1519464.HY22_00255 0.0 1189.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 CMS1_k127_4852928_4 379066.GAU_1219 1.717e-44 164.0 COG0462@1|root,COG0462@2|Bacteria,1ZT7Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N CMS1_k127_4870902_14 1123257.AUFV01000008_gene511 1.929e-05 46.0 COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,1RNM4@1236|Gammaproteobacteria,1X35B@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the mandelate racemase muconate lactonizing enzyme family - - 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N CMS1_k127_4870902_6 1379270.AUXF01000002_gene1577 1.579e-71 261.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4870902_1 861299.J421_3032 6.433e-155 514.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZTF0@142182|Gemmatimonadetes 142182|Gemmatimonadetes EU Acetyl xylan esterase (AXE1) - - - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_4870902_8 369723.Strop_1119 6.452e-58 226.0 COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4DA9Y@85008|Micromonosporales 201174|Actinobacteria P Part of an ABC transporter complex. Responsible for energy coupling to the transport system cbiO - - ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - ABC_tran CMS1_k127_4870902_13 1283299.AUKG01000002_gene4180 4.329e-11 77.0 COG0619@1|root,COG0619@2|Bacteria,2GKQ7@201174|Actinobacteria,4CQ7W@84995|Rubrobacteria 84995|Rubrobacteria P Cobalt transport protein - - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ CMS1_k127_4870902_9 56107.Cylst_3798 9.932e-47 180.0 COG0310@1|root,COG0310@2|Bacteria,1G40K@1117|Cyanobacteria,1HIGH@1161|Nostocales 1117|Cyanobacteria P PFAM Cobalt uptake substrate-specific transmembrane region cbiM - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM,PDGLE CMS1_k127_4870902_11 391603.FBALC1_06068 5.758e-30 130.0 2ESNM@1|root,33K76@2|Bacteria,4NYEG@976|Bacteroidetes,1IAX5@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_4870902_3 234267.Acid_2196 4.408e-105 352.0 COG2972@1|root,COG2972@2|Bacteria,3Y4IB@57723|Acidobacteria 57723|Acidobacteria T Histidine kinase - - - - - - - - - - - - His_kinase CMS1_k127_4870902_7 861299.J421_1363 2.028e-67 237.0 COG3279@1|root,COG3279@2|Bacteria,1ZTKG@142182|Gemmatimonadetes 2|Bacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - EAL,LytTR,Response_reg CMS1_k127_4870902_2 204669.Acid345_3588 1.461e-150 486.0 COG3503@1|root,COG3503@2|Bacteria,3Y6EK@57723|Acidobacteria,2JKNW@204432|Acidobacteriia 204432|Acidobacteriia S Protein of unknown function (DUF1624) - - - - - - - - - - - - DUF1624 CMS1_k127_4870902_10 929556.Solca_0662 2.372e-42 160.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase CMS1_k127_4870902_12 861299.J421_1614 5.97e-25 110.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family yjoA - - - - - - - - - - - DinB,DinB_2 CMS1_k127_4870902_4 861299.J421_1374 2.108e-102 345.0 COG2423@1|root,COG2423@2|Bacteria 2|Bacteria E ornithine cyclodeaminase activity ocd2 - 1.4.1.1,1.5.1.25,4.3.1.12 ko:K01750,ko:K18258,ko:K19244 ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230 - R00396,R00671 RC00008,RC00354 ko00000,ko00001,ko01000,ko04147 - - - OCD_Mu_crystall CMS1_k127_4870902_5 1205680.CAKO01000002_gene2142 7.582e-80 277.0 COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TV61@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Chromate resistance exported protein - - - - - - - - - - - - Chrome_Resist CMS1_k127_4870902_0 1336243.JAEA01000009_gene167 1.501e-158 513.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,1JRJU@119045|Methylobacteriaceae 28211|Alphaproteobacteria P TIGRFAM chromate transporter, chromate ion transporter (CHR) family MA20_36630 - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp CMS1_k127_4888090_3 396588.Tgr7_1994 9.67e-98 331.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales 135613|Chromatiales V ABC-type transport system, involved in lipoprotein release, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_4888090_0 1242864.D187_001016 2.449e-138 449.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 CMS1_k127_4888090_2 1122604.JONR01000034_gene421 2.371e-112 369.0 COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,1RSE9@1236|Gammaproteobacteria,1X73F@135614|Xanthomonadales 135614|Xanthomonadales S Predicted metal-binding integral membrane protein (DUF2182) - - - - - - - - - - - - DUF2182 CMS1_k127_4888090_1 485913.Krac_2755 2.721e-127 411.0 COG4312@1|root,COG4312@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF899) - - - - - - - - - - - - DUF899 CMS1_k127_4897337_0 1254432.SCE1572_02795 4.006e-123 409.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS1_k127_4897337_1 1267534.KB906760_gene1339 9.647e-44 167.0 COG2121@1|root,COG2121@2|Bacteria 2|Bacteria S Domain of unknown function (DUF374) MA20_05800 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527,ko:K09778 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - DUF374 CMS1_k127_4897337_2 1198452.Jab_2c26040 5.864e-16 80.0 COG5460@1|root,COG5460@2|Bacteria,1PTV0@1224|Proteobacteria,2W4JZ@28216|Betaproteobacteria 28216|Betaproteobacteria S Uncharacterized conserved protein (DUF2164) - - - - - - - - - - - - DUF2164 CMS1_k127_4917600_12 379066.GAU_0094 4.447e-13 82.0 COG0515@1|root,COG0515@2|Bacteria,1ZUHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_4917600_1 1210884.HG799472_gene14854 6.227e-209 667.0 COG2936@1|root,COG2936@2|Bacteria,2IY51@203682|Planctomycetes 203682|Planctomycetes S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 CMS1_k127_4917600_5 926569.ANT_13030 2.191e-131 435.0 COG0174@1|root,COG0174@2|Bacteria,2G61M@200795|Chloroflexi 200795|Chloroflexi E PFAM glutamine synthetase catalytic region - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N CMS1_k127_4917600_11 1379270.AUXF01000001_gene2004 4.578e-27 124.0 COG3137@1|root,COG3137@2|Bacteria,1ZUTC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 CMS1_k127_4917600_8 566466.NOR53_546 1.527e-57 217.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1JB6E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL CMS1_k127_4917600_3 1047013.AQSP01000110_gene79 2.064e-149 487.0 COG0733@1|root,COG0733@2|Bacteria,2NQIH@2323|unclassified Bacteria 2|Bacteria S Sodium:neurotransmitter symporter family CP_0468 - - ko:K03308,ko:K03466 - - - - ko00000,ko03036 2.A.22.4,2.A.22.5,3.A.12 - - SNF CMS1_k127_4917600_0 929556.Solca_0522 2.729e-217 688.0 COG1032@1|root,COG1032@2|Bacteria,4PHMM@976|Bacteroidetes,1IWI2@117747|Sphingobacteriia 976|Bacteroidetes C radical SAM domain protein - - - - - - - - - - - - - CMS1_k127_4917600_9 1121920.AUAU01000006_gene301 7.378e-48 178.0 2BYAB@1|root,32R2Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_4917600_7 314345.SPV1_13177 8.648e-119 393.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria 1224|Proteobacteria M mechanosensitive ion channel ynaI - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel CMS1_k127_4917600_10 1500259.JQLD01000005_gene108 5.634e-34 144.0 COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,2U39G@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Esterase PHB depolymerase - - - ko:K03932 - - - - ko00000 - CE1 - Abhydrolase_2,Esterase_phd CMS1_k127_4917600_6 861299.J421_0541 2.462e-125 425.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine ycbU - - - - - - - - - - - Aminotran_5 CMS1_k127_4917600_2 861299.J421_0538 4.558e-156 503.0 COG0733@1|root,COG0733@2|Bacteria 2|Bacteria S neurotransmitter:sodium symporter activity - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF CMS1_k127_4917600_4 1254432.SCE1572_22505 3.336e-139 458.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS1_k127_4921491_1 861299.J421_3506 1.873e-30 124.0 COG2262@1|root,COG2262@2|Bacteria,1ZSYM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 CMS1_k127_4924585_0 479432.Sros_4819 2.294e-206 655.0 COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4ENBU@85012|Streptosporangiales 201174|Actinobacteria Q Multicopper oxidase - - 1.3.3.5 ko:K08100 ko00860,ko01110,map00860,map01110 - R02394 RC01983 ko00000,ko00001,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_4924585_8 861299.J421_4408 9.467e-33 140.0 2FDKW@1|root,345N6@2|Bacteria,1ZU05@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - - CMS1_k127_4924585_9 861299.J421_4409 4.664e-13 78.0 COG2165@1|root,COG2165@2|Bacteria,1ZU7Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Prokaryotic N-terminal methylation motif - - - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl CMS1_k127_4924585_6 379066.GAU_2075 2.016e-48 177.0 COG2165@1|root,COG2165@2|Bacteria,1ZTUY@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Type II secretion system (T2SS), protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG CMS1_k127_4924585_4 861299.J421_4402 2.868e-94 330.0 COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes 2|Bacteria U Type II secretion system (T2SS), protein F xpsF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF CMS1_k127_4924585_3 671143.DAMO_2489 9.715e-140 462.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain xpsE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N CMS1_k127_4924585_1 861299.J421_4404 3.316e-156 520.0 COG1450@1|root,COG1450@2|Bacteria,1ZT9Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Bacterial type II and III secretion system protein - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N CMS1_k127_4924585_11 379066.GAU_1095 1.205e-09 67.0 2903E@1|root,2ZMTH@2|Bacteria,1ZU36@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Type II secretion system (T2SS), protein M subtype b - - - - - - - - - - - - T2SSM_b CMS1_k127_4924585_7 861299.J421_4407 1.768e-34 147.0 2FA0Q@1|root,3429T@2|Bacteria,1ZTZ0@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4924585_2 861299.J421_2577 1.946e-149 484.0 COG0436@1|root,COG0436@2|Bacteria,1ZT26@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class I and II - - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_4924585_5 479434.Sthe_2045 3.57e-62 233.0 COG0389@1|root,COG0389@2|Bacteria 2|Bacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII imuB - 2.7.7.7 ko:K02346,ko:K14161 - - - - ko00000,ko01000,ko03400 - - - IMS CMS1_k127_4945388_7 76114.ebA833 7.153e-43 168.0 COG0380@1|root,COG0561@1|root,COG0380@2|Bacteria,COG0561@2|Bacteria,1MUIY@1224|Proteobacteria,2W9UN@28216|Betaproteobacteria,2KYW0@206389|Rhodocyclales 206389|Rhodocyclales G Glycosyltransferase family 20 - - - - - - - - - - - - Glyco_transf_20 CMS1_k127_4945388_4 1089550.ATTH01000001_gene2420 2.983e-105 360.0 COG0380@1|root,COG0380@2|Bacteria,4NGJ4@976|Bacteroidetes,1FJ53@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Glycosyltransferase family 20 - - 2.4.1.15,2.4.1.347 ko:K00697 ko00500,ko01100,map00500,map01100 - R02737 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,S6PP CMS1_k127_4945388_2 247634.GPB2148_1908 1.088e-148 490.0 COG0591@1|root,COG0591@2|Bacteria,1PNHU@1224|Proteobacteria,1S0S6@1236|Gammaproteobacteria,1JAYJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF CMS1_k127_4945388_5 324057.Pjdr2_5277 1.084e-85 303.0 COG0673@1|root,COG0673@2|Bacteria,1TRCC@1239|Firmicutes,4HEB9@91061|Bacilli,26STK@186822|Paenibacillaceae 91061|Bacilli S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS1_k127_4945388_8 425104.Ssed_0138 7.434e-28 122.0 COG2995@1|root,COG2995@2|Bacteria,1RAF7@1224|Proteobacteria,1S0MG@1236|Gammaproteobacteria,2QBQT@267890|Shewanellaceae 1236|Gammaproteobacteria S Paraquat-inducible protein A - - - - - - - - - - - - PqiA CMS1_k127_4945388_0 1121930.AQXG01000011_gene1720 1.954e-182 595.0 COG2132@1|root,COG2132@2|Bacteria,4NE3N@976|Bacteroidetes 976|Bacteroidetes Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_4945388_3 1121930.AQXG01000011_gene1722 1.275e-133 445.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - LVIVD CMS1_k127_4945388_1 1379698.RBG1_1C00001G0607 3.926e-150 502.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 CMS1_k127_4945388_6 1047013.AQSP01000142_gene186 1.226e-51 185.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - - - - - - - - - - - DPPIV_N,Peptidase_S9 CMS1_k127_4948540_24 1123229.AUBC01000007_gene231 1.572e-16 79.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,2TR3D@28211|Alphaproteobacteria,3JUY2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Serine dehydratase alpha chain - - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta CMS1_k127_4948540_8 1211813.CAPH01000018_gene1083 5.389e-78 269.0 COG0299@1|root,COG3340@1|root,COG0299@2|Bacteria,COG3340@2|Bacteria,4NEXW@976|Bacteroidetes,2FQTC@200643|Bacteroidia,22U8N@171550|Rikenellaceae 976|Bacteroidetes E Belongs to the peptidase S51 family pepE - 3.4.13.21 ko:K05995 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S51 CMS1_k127_4948540_14 75379.Tint_3118 2.384e-49 181.0 COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,2VQZE@28216|Betaproteobacteria 28216|Betaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT CMS1_k127_4948540_13 1121904.ARBP01000009_gene4282 1.017e-56 214.0 COG0729@1|root,COG0729@2|Bacteria,4NMUN@976|Bacteroidetes,47MRN@768503|Cytophagia 976|Bacteroidetes M Surface antigen - - - - - - - - - - - - Bac_surface_Ag CMS1_k127_4948540_12 1121920.AUAU01000004_gene855 8.623e-62 216.0 COG0066@1|root,COG0066@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C CMS1_k127_4948540_3 1121920.AUAU01000004_gene856 7.779e-202 657.0 COG0065@1|root,COG0065@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity hacA - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase CMS1_k127_4948540_4 1121920.AUAU01000004_gene857 3.841e-199 627.0 COG1804@1|root,COG1804@2|Bacteria,3Y4ZM@57723|Acidobacteria 57723|Acidobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 CMS1_k127_4948540_7 1121920.AUAU01000004_gene858 1.434e-116 387.0 COG0119@1|root,COG0119@2|Bacteria,3Y2NJ@57723|Acidobacteria 57723|Acidobacteria E HMGL-like - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like CMS1_k127_4948540_5 1121920.AUAU01000004_gene859 1.474e-177 562.0 COG0473@1|root,COG0473@2|Bacteria,3Y2VW@57723|Acidobacteria 57723|Acidobacteria CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS1_k127_4948540_0 204669.Acid345_0280 0.0 1168.0 COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,3Y7G5@57723|Acidobacteria 57723|Acidobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N CMS1_k127_4948540_1 880073.Calab_2352 1.79e-239 749.0 COG0334@1|root,COG0334@2|Bacteria,2NNTY@2323|unclassified Bacteria 2|Bacteria E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase gdhA - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_4948540_27 485915.Dret_1277 9.294e-07 58.0 COG0348@1|root,COG0348@2|Bacteria,1R4WT@1224|Proteobacteria,42NQI@68525|delta/epsilon subdivisions,2WKGR@28221|Deltaproteobacteria,2M7YW@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding - - - - - - - - - - - - Fer4,Fer4_5,Fer4_9 CMS1_k127_4948540_2 1379270.AUXF01000005_gene764 3.006e-215 693.0 COG2366@1|root,COG2366@2|Bacteria,1ZUMU@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Penicillin amidase - - 3.5.1.97 ko:K07116 - - - - ko00000,ko01000 - - - Penicil_amidase CMS1_k127_4948540_25 880073.Calab_3438 3.046e-13 83.0 COG2314@1|root,COG2314@2|Bacteria,2NRTY@2323|unclassified Bacteria 2|Bacteria S TM2 domain - - - - - - - - - - - - TM2 CMS1_k127_4948540_23 379066.GAU_3741 8.709e-27 118.0 COG0702@1|root,COG0702@2|Bacteria,1ZUW3@142182|Gemmatimonadetes 142182|Gemmatimonadetes GM NmrA-like family - - - - - - - - - - - - NAD_binding_10 CMS1_k127_4948540_10 195250.CM001776_gene1111 8.815e-75 270.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 CMS1_k127_4948540_19 264732.Moth_2019 2.49e-31 138.0 COG1917@1|root,COG1917@2|Bacteria,1V6IB@1239|Firmicutes,24JTU@186801|Clostridia,42H4U@68295|Thermoanaerobacterales 186801|Clostridia S Cupin domain - - - - - - - - - - - - Cupin_2 CMS1_k127_4948540_6 1278073.MYSTI_06476 4.106e-172 555.0 COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,434NC@68525|delta/epsilon subdivisions,2WYZN@28221|Deltaproteobacteria,2Z10G@29|Myxococcales 28221|Deltaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase,DUF3471 CMS1_k127_4948540_16 941449.dsx2_2908 4.857e-44 181.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42MBJ@68525|delta/epsilon subdivisions,2WNWX@28221|Deltaproteobacteria,2MBDA@213115|Desulfovibrionales 28221|Deltaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly CMS1_k127_4948540_9 448385.sce5522 1.195e-75 275.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,2Z39Q@29|Myxococcales 28221|Deltaproteobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM CMS1_k127_4948540_26 1123261.AXDW01000007_gene2372 5.062e-07 57.0 2DSXM@1|root,33HUR@2|Bacteria,1NKYR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_4948540_20 1122604.JONR01000033_gene5 2.485e-30 136.0 COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria,1T1MG@1236|Gammaproteobacteria,1X53S@135614|Xanthomonadales 135614|Xanthomonadales S KR domain - - - - - - - - - - - - adh_short CMS1_k127_4948540_15 714943.Mucpa_6877 1.857e-44 183.0 COG0382@1|root,COG0382@2|Bacteria 2|Bacteria H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39,2.5.1.42 ko:K03179,ko:K17105 ko00130,ko00564,ko01100,ko01110,map00130,map00564,map01100,map01110 M00117 R04520,R05000,R05615 RC00209,RC01171,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA CMS1_k127_4948540_17 1169152.AXVD01000013_gene1675 9.573e-42 175.0 COG1597@1|root,COG1597@2|Bacteria,2HHKU@201174|Actinobacteria,4FZ0T@85025|Nocardiaceae 201174|Actinobacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat CMS1_k127_4948540_22 1121861.KB899938_gene4016 9.088e-29 133.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2TTI6@28211|Alphaproteobacteria,2JQC6@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS1_k127_4948540_18 1232410.KI421413_gene779 1.472e-37 149.0 COG3794@1|root,COG3794@2|Bacteria,1N3IJ@1224|Proteobacteria,42TYB@68525|delta/epsilon subdivisions,2WR42@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome P460 - - - - - - - - - - - - Cytochrome_P460 CMS1_k127_4948540_11 266117.Rxyl_2864 6.263e-70 257.0 COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4CQJ5@84995|Rubrobacteria 84995|Rubrobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR CMS1_k127_4948540_21 945713.IALB_0020 4.729e-29 130.0 COG4747@1|root,COG4747@2|Bacteria 2|Bacteria - - hom - 1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00025,M00570 R00220,R00996,R01513,R01728,R01773,R01775 RC00031,RC00087,RC00125,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3 CMS1_k127_4986890_6 373994.Riv7116_2124 2.573e-05 54.0 COG1943@1|root,COG1943@2|Bacteria,1G5SV@1117|Cyanobacteria,1HS7P@1161|Nostocales 1117|Cyanobacteria L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp CMS1_k127_4986890_0 682795.AciX8_4155 1.116e-259 853.0 COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia 204432|Acidobacteriia S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 CMS1_k127_4986890_5 379066.GAU_3920 3.435e-10 74.0 COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,1ZTYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Leishmanolysin - - - - - - - - - - - - Peptidase_M8 CMS1_k127_4986890_4 861299.J421_3139 4.247e-48 177.0 COG0590@1|root,COG0590@2|Bacteria,1ZTW9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33,3.8.1.5 ko:K01563,ko:K11991 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223 RC00477,RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000,ko03016 - - - MafB19-deam CMS1_k127_4986890_1 582515.KR51_00032060 3.36e-176 579.0 COG0855@1|root,COG0855@2|Bacteria,1G1WA@1117|Cyanobacteria 1117|Cyanobacteria P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N CMS1_k127_4986890_2 1234595.C725_1938 9.567e-106 363.0 COG0006@1|root,COG0006@2|Bacteria,1NR7D@1224|Proteobacteria,2UPAG@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Creatinase/Prolidase N-terminal domain - - - - - - - - - - - - Creatinase_N,Peptidase_M24 CMS1_k127_4986890_3 316274.Haur_3795 4.112e-52 190.0 COG1528@1|root,COG1528@2|Bacteria,2G8JG@200795|Chloroflexi,37728@32061|Chloroflexia 32061|Chloroflexia C Iron-storage protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin CMS1_k127_4986890_7 1197906.CAJQ02000027_gene1525 0.0001086 45.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JV1X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Recombinase zinc beta ribbon domain - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom CMS1_k127_4986890_8 762211.BSTEL_0678 0.0005415 48.0 COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,4CZA9@85004|Bifidobacteriales 201174|Actinobacteria L Phage integrase family intA - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase CMS1_k127_4994010_3 1210884.HG799463_gene9540 2.249e-216 699.0 COG3250@1|root,COG3250@2|Bacteria,2IWTW@203682|Planctomycetes 203682|Planctomycetes G Glycosyl hydrolases family 2 - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Glyco_hydro_43 CMS1_k127_4994010_5 1242864.D187_005861 2.717e-177 573.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YVB7@29|Myxococcales 28221|Deltaproteobacteria J Amidase - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase CMS1_k127_4994010_1 1499967.BAYZ01000080_gene919 8.194e-236 747.0 COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria 2|Bacteria S Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Glyco_hydro_127 CMS1_k127_4994010_14 1211114.ALIP01000083_gene1535 5.409e-92 321.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1S5WE@1236|Gammaproteobacteria,1X3ZI@135614|Xanthomonadales 135614|Xanthomonadales V beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_4994010_32 882083.SacmaDRAFT_4084 9.923e-09 59.0 COG2331@1|root,COG2331@2|Bacteria,2GR6C@201174|Actinobacteria,4E6SR@85010|Pseudonocardiales 201174|Actinobacteria S regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 CMS1_k127_4994010_29 1045858.Bint_1048 7.164e-18 89.0 COG2331@1|root,COG2331@2|Bacteria,2J904@203691|Spirochaetes 203691|Spirochaetes S FmdB family - - - - - - - - - - - - Zn-ribbon_8 CMS1_k127_4994010_2 1379270.AUXF01000005_gene719 3.926e-223 711.0 COG0018@1|root,COG0018@2|Bacteria,1ZT6E@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Arginyl tRNA synthetase N terminal dom argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d CMS1_k127_4994010_11 861299.J421_3111 2.909e-120 394.0 COG0524@1|root,COG0524@2|Bacteria,1ZSUT@142182|Gemmatimonadetes 142182|Gemmatimonadetes G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB CMS1_k127_4994010_13 379066.GAU_1469 1.662e-96 336.0 COG0150@1|root,COG0150@2|Bacteria,1ZSQJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F AIR synthase related protein, C-terminal domain purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS1_k127_4994010_15 861299.J421_3114 1.422e-88 304.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1ZSNI@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate - - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 CMS1_k127_4994010_19 429009.Adeg_1981 5.226e-50 184.0 COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,42GDH@68295|Thermoanaerobacterales 186801|Clostridia H TIGRFAM riboflavin synthase, alpha subunit ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding CMS1_k127_4994010_4 861299.J421_3116 2.518e-186 591.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1ZT7J@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 CMS1_k127_4994010_24 1304875.JAFZ01000001_gene1774 2.2e-35 140.0 COG0054@1|root,COG0054@2|Bacteria,3TAV8@508458|Synergistetes 508458|Synergistetes H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase CMS1_k127_4994010_26 861299.J421_3118 1.089e-21 101.0 COG0781@1|root,COG0781@2|Bacteria,1ZTRU@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB CMS1_k127_4994010_8 861299.J421_3119 1.105e-126 422.0 COG0438@1|root,COG0438@2|Bacteria,1ZTBC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_4994010_33 1111131.HMPREF1255_1391 0.0004125 51.0 COG1544@1|root,COG1544@2|Bacteria,2GMYF@201174|Actinobacteria,4DQCT@85009|Propionibacteriales 201174|Actinobacteria J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE CMS1_k127_4994010_10 861299.J421_3121 1.547e-120 397.0 COG1493@1|root,COG1493@2|Bacteria,1ZSY3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N CMS1_k127_4994010_31 379066.GAU_1478 1.908e-13 75.0 COG2893@1|root,COG2893@2|Bacteria,1ZU41@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system fructose IIA component - - - ko:K02744 ko00052,ko02060,map00052,map02060 M00277,M00287 R08366,R08367 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1.4,4.A.6.1.5 - - EIIA-man CMS1_k127_4994010_23 861299.J421_3123 7.171e-41 161.0 COG3444@1|root,COG3444@2|Bacteria,1ZTQR@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system sorbose subfamily IIB component - - - ko:K19507 ko02060,map02060 M00764 - - ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1.19 - - PTSIIB_sorb CMS1_k127_4994010_30 1379270.AUXF01000005_gene733 1.307e-16 92.0 COG3715@1|root,COG3715@2|Bacteria,1ZTVH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system sorbose-specific iic component - - - ko:K02795 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EII-Sor CMS1_k127_4994010_22 379066.GAU_1481 3.599e-46 179.0 COG3716@1|root,COG3716@2|Bacteria,1ZTJH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system mannose/fructose/sorbose family IID component - - - ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EIID-AGA CMS1_k127_4994010_27 379066.GAU_1482 1.115e-20 104.0 COG1925@1|root,COG1925@2|Bacteria,1ZTYE@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS HPr component phosphorylation site - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr CMS1_k127_4994010_12 1192034.CAP_4136 1.817e-116 397.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2YY2C@29|Myxococcales 28221|Deltaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.1.202,2.7.3.9 ko:K02768,ko:K08483,ko:K11183 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr CMS1_k127_4994010_6 379066.GAU_1484 4.738e-165 529.0 COG0192@1|root,COG0192@2|Bacteria,1ZSZ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N CMS1_k127_4994010_0 861299.J421_2862 6.885e-247 773.0 COG0499@1|root,COG0499@2|Bacteria,1ZTEF@142182|Gemmatimonadetes 142182|Gemmatimonadetes H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD CMS1_k127_4994010_18 861299.J421_3129 1.477e-51 188.0 COG1259@1|root,COG1259@2|Bacteria,1ZTKW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase CMS1_k127_4994010_28 379066.GAU_1486 1.075e-19 102.0 COG2010@1|root,COG2010@2|Bacteria,1ZT9T@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c - - - - - - - - - - - - - CMS1_k127_4994010_21 1379270.AUXF01000005_gene740 3.071e-48 183.0 COG0614@1|root,COG0614@2|Bacteria,1ZTIM@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 CMS1_k127_4994010_16 379066.GAU_0496 2.175e-65 245.0 COG0609@1|root,COG0609@2|Bacteria,1ZTAA@142182|Gemmatimonadetes 2|Bacteria P FecCD transport family btuC - 3.6.3.34 ko:K02013,ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - FecCD CMS1_k127_4994010_17 861299.J421_3133 2.844e-52 208.0 COG1120@1|root,COG1120@2|Bacteria,1ZTB9@142182|Gemmatimonadetes 142182|Gemmatimonadetes P ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran CMS1_k127_4994010_7 861299.J421_3134 3.324e-131 455.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity btuB - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec CMS1_k127_4994010_20 861299.J421_3135 3.818e-49 186.0 COG1381@1|root,COG1381@2|Bacteria,1ZTHP@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N CMS1_k127_4994010_9 1125863.JAFN01000001_gene3091 7.4e-123 418.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria 28221|Deltaproteobacteria J elongation factor SelB, winged helix selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 CMS1_k127_4994010_25 861299.J421_3136 4.993e-29 122.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DctA-YdbH CMS1_k127_4999891_2 1379270.AUXF01000003_gene3848 3.806e-15 80.0 2C803@1|root,33Q52@2|Bacteria,1ZTK6@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_4999891_0 1379270.AUXF01000003_gene3853 1.144e-132 440.0 COG0591@1|root,COG0591@2|Bacteria,1ZTEB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Sodium:solute symporter family - - - - - - - - - - - - SSF CMS1_k127_4999891_1 861299.J421_3606 1.695e-19 87.0 COG0316@1|root,COG0316@2|Bacteria,1ZTT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulphur cluster biosynthesis - - - - - - - - - - - - Fe-S_biosyn CMS1_k127_5026162_2 861299.J421_6304 1.259e-117 388.0 COG4447@1|root,COG4447@2|Bacteria,1ZUBH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 CMS1_k127_5026162_0 861299.J421_6304 0.0 1255.0 COG4447@1|root,COG4447@2|Bacteria,1ZUBH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 CMS1_k127_5026162_1 1144275.COCOR_04568 2.248e-191 611.0 COG2234@1|root,COG2234@2|Bacteria,1R77P@1224|Proteobacteria 1224|Proteobacteria N Aminopeptidase - - - - - - - - - - - - PA,Peptidase_M28 CMS1_k127_5026162_3 1179773.BN6_52060 9.946e-10 70.0 COG0823@1|root,COG0823@2|Bacteria,2GMNT@201174|Actinobacteria,4DY93@85010|Pseudonocardiales 201174|Actinobacteria U WD40-like Beta Propeller Repeat - - - - - - - - - - - - DUF11,PD40 CMS1_k127_5026162_4 675635.Psed_6436 1.875e-07 59.0 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4EF7J@85010|Pseudonocardiales 201174|Actinobacteria T Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,Trans_reg_C CMS1_k127_5041457_2 96561.Dole_2417 8.363e-72 261.0 COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales 28221|Deltaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 CMS1_k127_5041457_1 96561.Dole_2419 1.098e-74 275.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales 28221|Deltaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 CMS1_k127_5041457_3 1043493.BBLU01000019_gene1520 3.695e-52 201.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_5041457_0 1123234.AUKI01000015_gene2306 6.041e-79 274.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_5041906_4 1382306.JNIM01000001_gene1964 3.348e-85 290.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine ycbU - - - - - - - - - - - Aminotran_5 CMS1_k127_5041906_5 379066.GAU_2861 6.722e-84 288.0 COG1611@1|root,COG1611@2|Bacteria,1ZT7E@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox CMS1_k127_5041906_2 251221.35211608 3.842e-155 499.0 COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria 1117|Cyanobacteria O Belongs to the deoxyhypusine synthase family - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS CMS1_k127_5041906_6 443144.GM21_2012 7.697e-57 218.0 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,43CB2@68525|delta/epsilon subdivisions,2X7MH@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP Major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 CMS1_k127_5041906_3 861299.J421_4546 9.07e-139 462.0 COG0578@1|root,COG0578@2|Bacteria,1ZT6P@142182|Gemmatimonadetes 142182|Gemmatimonadetes C C-terminal domain of alpha-glycerophosphate oxidase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C CMS1_k127_5041906_7 338963.Pcar_0025 1.236e-21 106.0 COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,42VAD@68525|delta/epsilon subdivisions,2WRMT@28221|Deltaproteobacteria,43SM5@69541|Desulfuromonadales 28221|Deltaproteobacteria H Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25,TehB CMS1_k127_5041906_1 1379270.AUXF01000001_gene2466 4.076e-168 538.0 COG0183@1|root,COG0183@2|Bacteria,1ZSW1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thiolase, C-terminal domain - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N CMS1_k127_5041906_0 379066.GAU_2856 4.283e-176 580.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1ZT1A@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Enoyl-CoA hydratase/isomerase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 CMS1_k127_5089217_8 497964.CfE428DRAFT_5487 2.573e-30 143.0 COG3210@1|root,COG4625@1|root,COG3210@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis - - - - - - - - - - - - Autotransporter,Calx-beta,ESPR,FG-GAP,PATR CMS1_k127_5089217_0 290397.Adeh_1417 1.797e-208 668.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42PMK@68525|delta/epsilon subdivisions,2X5G7@28221|Deltaproteobacteria,2Z35F@29|Myxococcales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_5089217_9 1110697.NCAST_23_00040 8.965e-09 65.0 COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4FUHA@85025|Nocardiaceae 201174|Actinobacteria S Phosphoribosyl transferase domain - - - ko:K07100 - - - - ko00000 - - - Pribosyltran CMS1_k127_5089217_3 861299.J421_0065 2.461e-136 466.0 COG2120@1|root,COG2120@2|Bacteria,1ZT6U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L CMS1_k127_5089217_6 997346.HMPREF9374_2154 6.935e-86 303.0 COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,4HABY@91061|Bacilli,27CM5@186824|Thermoactinomycetaceae 91061|Bacilli P Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 CMS1_k127_5089217_7 1160137.KB907308_gene7846 2.71e-73 272.0 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4FZDM@85025|Nocardiaceae 201174|Actinobacteria E Belongs to the ABC transporter superfamily potA - 3.6.3.30 ko:K02010,ko:K02052 ko02010,ko02024,map02010,map02024 M00190,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11 - - ABC_tran,TOBE_2 CMS1_k127_5089217_4 997346.HMPREF9374_2151 4.687e-127 428.0 COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HA2U@91061|Bacilli,27CKY@186824|Thermoactinomycetaceae 91061|Bacilli P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 CMS1_k127_5089217_5 1379270.AUXF01000002_gene1761 3.027e-102 370.0 COG0477@1|root,COG2814@2|Bacteria,1ZT84@142182|Gemmatimonadetes 142182|Gemmatimonadetes EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr CMS1_k127_5089217_1 945713.IALB_1608 1.022e-143 487.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM CMS1_k127_5089217_10 1121405.dsmv_1947 4.571e-05 52.0 COG0517@1|root,COG2204@1|root,COG0517@2|Bacteria,COG2204@2|Bacteria,1NMVW@1224|Proteobacteria,42N24@68525|delta/epsilon subdivisions,2WIQ6@28221|Deltaproteobacteria,2MJ9K@213118|Desulfobacterales 28221|Deltaproteobacteria T CBS domain containing protein - - - - - - - - - - - - CBS,Response_reg CMS1_k127_5089217_2 234267.Acid_7947 9.198e-137 454.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_5114200_1 379066.GAU_1315 3.725e-70 245.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cebB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23,HlyD_D4,YtkA CMS1_k127_5114200_0 941449.dsx2_0363 0.0 1300.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2M9PX@213115|Desulfovibrionales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran CMS1_k127_5154036_1 1487953.JMKF01000028_gene1253 9.286e-194 642.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H9JN@1150|Oscillatoriales 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,FHA,GAF,GGDEF,PAS_3,PAS_9,Response_reg CMS1_k127_5154036_4 861299.J421_2864 7.514e-113 380.0 COG2133@1|root,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - CBM_2,GSDH CMS1_k127_5154036_6 1232410.KI421428_gene1003 1.218e-67 248.0 COG2199@1|root,COG2199@2|Bacteria,1R80Z@1224|Proteobacteria,42RXX@68525|delta/epsilon subdivisions,2WNME@28221|Deltaproteobacteria,43TKF@69541|Desulfuromonadales 28221|Deltaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF CMS1_k127_5154036_5 1961.JOAK01000033_gene774 1.917e-71 252.0 COG1524@1|root,COG1524@2|Bacteria,2HQI2@201174|Actinobacteria 201174|Actinobacteria I type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest CMS1_k127_5154036_2 861299.J421_6092 1.132e-122 415.0 COG1680@1|root,COG1680@2|Bacteria,1ZUKR@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Domain of unknown function (DUF3471) - - - - - - - - - - - - Beta-lactamase,DUF3471 CMS1_k127_5154036_0 1047013.AQSP01000092_gene315 0.0 1116.0 COG3250@1|root,COG3250@2|Bacteria,2NQEM@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolases family 2, TIM barrel domain lacZ GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0032991,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575,GO:1902494 3.2.1.23,3.2.1.31 ko:K01190,ko:K01195 ko00040,ko00052,ko00511,ko00531,ko00600,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00052,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01105,R01478,R01678,R03355,R04783,R04979,R06114,R07818,R08127,R08260,R10830 RC00049,RC00055,RC00171,RC00452,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N CMS1_k127_5154036_7 234267.Acid_6592 2.193e-64 236.0 COG0153@1|root,COG0153@2|Bacteria,3Y300@57723|Acidobacteria 2|Bacteria G Belongs to the GHMP kinase family. GalK subfamily - - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg CMS1_k127_5154036_3 1122179.KB890441_gene1057 7.875e-117 384.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1IW3G@117747|Sphingobacteriia 976|Bacteroidetes E Sodium:solute symporter family - - - - - - - - - - - - SSF CMS1_k127_5164386_5 1089547.KB913013_gene4420 3.544e-25 106.0 COG0135@1|root,COG0135@2|Bacteria,4NK5D@976|Bacteroidetes,47NUD@768503|Cytophagia 976|Bacteroidetes E N-(5'phosphoribosyl)anthranilate (PRA) isomerase - - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI CMS1_k127_5164386_0 313606.M23134_03071 0.0 1070.0 COG1629@1|root,COG1629@2|Bacteria,4PM06@976|Bacteroidetes,47Y21@768503|Cytophagia 976|Bacteroidetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,TonB_dep_Rec CMS1_k127_5164386_2 997346.HMPREF9374_3654 5.388e-127 423.0 COG0329@1|root,COG0329@2|Bacteria,1UNIU@1239|Firmicutes,4HAWE@91061|Bacilli,27CTM@186824|Thermoactinomycetaceae 91061|Bacilli EM Dihydrodipicolinate synthetase family - - - - - - - - - - - - DHDPS CMS1_k127_5164386_3 1232443.BAIA02000148_gene1582 2.279e-51 208.0 COG0451@1|root,COG0451@2|Bacteria,1TPHV@1239|Firmicutes,24G2K@186801|Clostridia 186801|Clostridia GM NAD dependent epimerase/dehydratase family - - - - - - - - - - - - Epimerase CMS1_k127_5164386_1 1380355.JNIJ01000004_gene3003 2.448e-192 610.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,3JSHP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 CMS1_k127_5164386_4 1122138.AQUZ01000019_gene8181 3.863e-45 171.0 COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4DQID@85009|Propionibacteriales 201174|Actinobacteria Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 CMS1_k127_5197904_42 1121439.dsat_1465 2.557e-16 82.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2M9HU@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein hmcB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_11,Fer4_4,Fer4_7 CMS1_k127_5197904_12 439235.Dalk_1856 1.957e-113 385.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD fdnI - - - - - - - - - - iAF987.Gmet_1061 NrfD CMS1_k127_5197904_7 880073.Calab_1599 1.805e-139 469.0 COG2864@1|root,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria 2|Bacteria C Cytochrome b subunit of formate dehydrogenase-like protein - - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS1_k127_5197904_18 671143.DAMO_0826 5.377e-97 350.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - ko:K02569,ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT,Cytochrome_C7 CMS1_k127_5197904_30 671143.DAMO_0822 5.586e-55 218.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS1_k127_5197904_28 234267.Acid_6208 1.224e-57 216.0 COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3Y4F0@57723|Acidobacteria 57723|Acidobacteria C Cytochrome b(C-terminal)/b6/petD - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C,Cytochrome_B CMS1_k127_5197904_51 194439.CT0302 0.0001815 51.0 COG0723@1|root,COG0723@2|Bacteria,1FE1T@1090|Chlorobi 1090|Chlorobi C PFAM Rieske 2Fe-2S domain protein - - 1.10.9.1 ko:K02636 ko00195,ko01100,map00195,map01100 M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - - CytB6-F_Fe-S,Rieske CMS1_k127_5197904_39 1191523.MROS_2048 1.111e-24 120.0 COG0737@1|root,COG3303@1|root,COG0737@2|Bacteria,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C,Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1,SBP_bac_8,SLH CMS1_k127_5197904_49 1000565.METUNv1_03628 4.334e-13 80.0 28TB7@1|root,2ZFJR@2|Bacteria,1PACM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_5197904_8 1232410.KI421428_gene1054 3.715e-131 454.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains REC, sigma54 interaction, HTH8 - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_5197904_31 1125863.JAFN01000001_gene973 2.419e-50 201.0 COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,42TFH@68525|delta/epsilon subdivisions,2WPEH@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase HAMP - - - - - - - - - - - - HAMP,HATPase_c,HisKA CMS1_k127_5197904_48 1394178.AWOO02000024_gene5674 3.432e-13 75.0 COG2197@1|root,COG2197@2|Bacteria,2GN80@201174|Actinobacteria 201174|Actinobacteria T response regulator, receiver - - - - - - - - - - - - GerE,Response_reg CMS1_k127_5197904_46 1382359.JIAL01000001_gene323 1.393e-13 75.0 COG2010@1|root,COG2010@2|Bacteria,3Y5MU@57723|Acidobacteria,2JJWK@204432|Acidobacteriia 204432|Acidobacteriia C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 CMS1_k127_5197904_40 338963.Pcar_2550 1.344e-24 110.0 COG3303@1|root,COG3303@2|Bacteria,1QY22@1224|Proteobacteria,43C9D@68525|delta/epsilon subdivisions,2WQ1C@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 CMS1_k127_5197904_14 1379698.RBG1_1C00001G0855 4.217e-111 395.0 COG0243@1|root,COG0243@2|Bacteria,2NPRJ@2323|unclassified Bacteria 2|Bacteria C Molydopterin dinucleotide binding domain qrcB - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS1_k127_5197904_16 1379698.RBG1_1C00001G0856 1.113e-98 327.0 COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7 CMS1_k127_5197904_6 1379698.RBG1_1C00001G0857 4.567e-151 494.0 COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria 1379698.RBG1_1C00001G0857|- C Polysulphide reductase, NrfD - - - - - - - - - - - - - CMS1_k127_5197904_21 1379698.RBG1_1C00001G0858 6.949e-78 290.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C CMS1_k127_5197904_24 1379698.RBG1_1C00001G0858 3.201e-68 247.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C CMS1_k127_5197904_5 246194.CHY_1839 2.28e-155 505.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,42FD3@68295|Thermoanaerobacterales 186801|Clostridia F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N CMS1_k127_5197904_13 861299.J421_2340 1.714e-112 379.0 COG1158@1|root,COG1158@2|Bacteria,1ZTA0@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_RNA_bind CMS1_k127_5197904_34 266809.PM03_15755 4.022e-39 148.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,2UC0B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-binding protein - - - - - - - - - - - - DUF411 CMS1_k127_5197904_19 861299.J421_2731 3.656e-86 300.0 COG1195@1|root,COG1195@2|Bacteria,1ZSRU@142182|Gemmatimonadetes 142182|Gemmatimonadetes L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N CMS1_k127_5197904_50 1379270.AUXF01000004_gene3081 3.865e-11 68.0 COG5512@1|root,COG5512@2|Bacteria,1ZTYN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 CMS1_k127_5197904_2 665952.HMPREF1015_01835 2.241e-252 799.0 COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H9Y6@91061|Bacilli,1ZBFI@1386|Bacillus 91061|Bacilli L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim CMS1_k127_5197904_47 926561.KB900623_gene818 2.81e-13 73.0 COG0640@1|root,COG0640@2|Bacteria,1V6CU@1239|Firmicutes,24R9E@186801|Clostridia 186801|Clostridia K regulatory protein, arsR - - - ko:K03892,ko:K21903 - - - - ko00000,ko03000 - - - HTH_5 CMS1_k127_5197904_35 309807.SRU_1978 1.958e-37 157.0 COG1538@1|root,COG1538@2|Bacteria,4NE4S@976|Bacteroidetes,1FJVV@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS1_k127_5197904_36 517418.Ctha_2707 1.008e-32 144.0 COG0845@1|root,COG0845@2|Bacteria,1FE89@1090|Chlorobi 1090|Chlorobi M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 CMS1_k127_5197904_0 1379270.AUXF01000001_gene2734 0.0 1068.0 COG0841@1|root,COG0841@2|Bacteria,1ZUDY@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Protein export membrane protein - - - - - - - - - - - - ACR_tran CMS1_k127_5197904_52 555779.Dthio_PD0961 0.000233 51.0 2CKUB@1|root,34BQT@2|Bacteria,1P2NW@1224|Proteobacteria,431FP@68525|delta/epsilon subdivisions,2WW8P@28221|Deltaproteobacteria,2MFE3@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_5197904_43 886377.Murru_1589 9.024e-16 81.0 COG0607@1|root,30IQR@2|Bacteria,4NVMW@976|Bacteroidetes,1I52X@117743|Flavobacteriia 976|Bacteroidetes P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 CMS1_k127_5197904_1 379066.GAU_0972 0.0 1033.0 COG2866@1|root,COG2866@2|Bacteria,1ZUMZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS1_k127_5197904_9 861299.J421_0810 7.836e-128 423.0 COG0624@1|root,COG0624@2|Bacteria 2|Bacteria E succinyl-diaminopimelate desuccinylase activity cpg2_2 - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS1_k127_5197904_33 1128421.JAGA01000001_gene2144 2.235e-40 158.0 COG3127@1|root,COG3127@2|Bacteria 2|Bacteria Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5197904_38 234267.Acid_6293 4.865e-31 125.0 COG1846@1|root,COG1846@2|Bacteria,3Y861@57723|Acidobacteria 57723|Acidobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - HTH_34 CMS1_k127_5197904_23 288000.BBta_7856 4.544e-69 246.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TU0N@28211|Alphaproteobacteria,3JT02@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids MA20_23565 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf CMS1_k127_5197904_37 1379270.AUXF01000001_gene2135 2.941e-31 141.0 COG3871@1|root,COG3871@2|Bacteria 2|Bacteria S Pyridoxamine 5'-phosphate oxidase ydaG - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - Putative_PNPOx,Pyrid_ox_like CMS1_k127_5197904_10 880073.Calab_2482 3.753e-119 400.0 COG0534@1|root,COG0534@2|Bacteria,2NPFE@2323|unclassified Bacteria 2|Bacteria V Mate efflux family protein - - - - - - - - - - - - ANKH,MatE CMS1_k127_5197904_17 1519464.HY22_05180 1.406e-97 328.0 COG1131@1|root,COG1131@2|Bacteria,1FF0I@1090|Chlorobi 1090|Chlorobi V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_5197904_41 1519464.HY22_08895 1.269e-22 114.0 COG1277@1|root,COG1277@2|Bacteria,1FFEA@1090|Chlorobi 1090|Chlorobi S ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_4 CMS1_k127_5197904_3 502025.Hoch_2105 2.313e-185 611.0 COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,438BA@68525|delta/epsilon subdivisions,2X3KK@28221|Deltaproteobacteria,2YWFN@29|Myxococcales 28221|Deltaproteobacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS1_k127_5197904_22 861299.J421_0341 2.278e-76 285.0 COG0745@1|root,COG0745@2|Bacteria,1ZUFQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C CMS1_k127_5197904_25 861299.J421_0342 2.339e-67 250.0 COG0642@1|root,COG2205@2|Bacteria,1ZUZJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA CMS1_k127_5197904_44 861299.J421_5897 1.973e-15 79.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_5897|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_5197904_20 861299.J421_2808 4.765e-84 290.0 COG0492@1|root,COG0492@2|Bacteria,1ZSW9@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_3 CMS1_k127_5197904_27 1254432.SCE1572_29970 4.118e-60 214.0 COG1309@1|root,COG1309@2|Bacteria,1R6RX@1224|Proteobacteria,42T50@68525|delta/epsilon subdivisions,2WPVV@28221|Deltaproteobacteria,2YUY1@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N CMS1_k127_5197904_32 1121920.AUAU01000004_gene862 2.127e-45 175.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4 CMS1_k127_5197904_26 926550.CLDAP_20140 6e-64 237.0 COG2193@1|root,COG2193@2|Bacteria,2G6RN@200795|Chloroflexi 200795|Chloroflexi P Ferritin-like domain - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin CMS1_k127_5197904_45 504472.Slin_0288 1.143e-14 85.0 COG3358@1|root,COG3358@2|Bacteria,4NNWJ@976|Bacteroidetes,47Q5N@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1684) - - - ko:K09164 - - - - ko00000 - - - DUF1684 CMS1_k127_5197904_29 391625.PPSIR1_19304 1.231e-55 218.0 COG0526@1|root,COG0526@2|Bacteria,1QZTD@1224|Proteobacteria 1224|Proteobacteria CO AhpC/TSA family - - - - - - - - - - - - AhpC-TSA,Redoxin CMS1_k127_5197904_4 379066.GAU_3212 2.191e-158 514.0 COG0006@1|root,COG0006@2|Bacteria,1ZUGP@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminopeptidase P, N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 CMS1_k127_5197904_11 1128421.JAGA01000003_gene2922 5.584e-117 383.0 COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria 2|Bacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_7,Fer4_8 CMS1_k127_5197904_15 383372.Rcas_3080 1.893e-109 357.0 COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia 32061|Chloroflexia C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS1_k127_5283811_5 945713.IALB_0020 6.028e-22 96.0 COG4747@1|root,COG4747@2|Bacteria 2|Bacteria - - hom - 1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00025,M00570 R00220,R00996,R01513,R01728,R01773,R01775 RC00031,RC00087,RC00125,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3 CMS1_k127_5283811_2 290397.Adeh_0133 5.845e-71 257.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WNXT@28221|Deltaproteobacteria,2YV4W@29|Myxococcales 28221|Deltaproteobacteria EGP of the major facilitator superfamily agmP - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1,MFS_1_like,Sugar_tr CMS1_k127_5283811_6 861299.J421_0327 4.112e-15 77.0 COG4117@1|root,COG4117@2|Bacteria,1ZUUH@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB CMS1_k127_5283811_3 1519464.HY22_05460 8.139e-39 152.0 COG1595@1|root,COG1595@2|Bacteria,1FDU7@1090|Chlorobi 1090|Chlorobi K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_5283811_8 426117.M446_4787 9.021e-07 60.0 COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,1JU5T@119045|Methylobacteriaceae 28211|Alphaproteobacteria K AntiSigma factor - - - - - - - - - - - - zf-HC2 CMS1_k127_5283811_1 861299.J421_0542 7.048e-82 287.0 COG3576@1|root,COG3576@2|Bacteria 2|Bacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx CMS1_k127_5283811_4 1267535.KB906767_gene2169 2.174e-33 136.0 COG0457@1|root,COG0457@2|Bacteria,3Y7T2@57723|Acidobacteria,2JP3F@204432|Acidobacteriia 204432|Acidobacteriia S Protein of unknown function (DUF2911) - - - - - - - - - - - - DUF2911 CMS1_k127_5283811_0 313603.FB2170_01836 0.0 1267.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1HYJJ@117743|Flavobacteriia,2PGS6@252356|Maribacter 976|Bacteroidetes M Tricorn protease C1 domain - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ CMS1_k127_5312622_15 760192.Halhy_2529 4.984e-22 101.0 COG2172@1|root,COG2172@2|Bacteria,4NRAA@976|Bacteroidetes,1IT0C@117747|Sphingobacteriia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase rsbW - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 CMS1_k127_5312622_13 861299.J421_3455 9.226e-37 143.0 COG1366@1|root,COG1366@2|Bacteria,1ZTXM@142182|Gemmatimonadetes 142182|Gemmatimonadetes T STAS domain - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS CMS1_k127_5312622_7 379066.GAU_1886 1.543e-80 288.0 COG0280@1|root,COG0280@2|Bacteria,1ZT01@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Phosphate acetyl/butaryl transferase - - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB CMS1_k127_5312622_11 411462.DORLON_00461 1.411e-40 166.0 COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,27VHR@189330|Dorea 186801|Clostridia H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like CMS1_k127_5312622_10 861299.J421_3458 4.4e-46 190.0 COG0742@1|root,COG0742@2|Bacteria,1ZTVS@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Conserved hypothetical protein 95 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 CMS1_k127_5312622_0 379066.GAU_1889 1.51e-148 497.0 COG0608@1|root,COG0608@2|Bacteria,1ZTGC@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DHH family - - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 CMS1_k127_5312622_16 379066.GAU_1890 2.832e-17 91.0 COG1579@1|root,COG1579@2|Bacteria,1ZU01@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Zn-ribbon protein possibly nucleic acid-binding - - - ko:K07164 - - - - ko00000 - - - - CMS1_k127_5312622_6 518766.Rmar_0977 3.761e-90 321.0 COG0358@1|root,COG0358@2|Bacteria,4NENT@976|Bacteroidetes,1FJ4P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 CMS1_k127_5312622_1 861299.J421_3463 2.101e-145 489.0 COG1193@1|root,COG1193@2|Bacteria,1ZSWM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr CMS1_k127_5312622_14 379066.GAU_1894 3.115e-24 104.0 COG0828@1|root,COG0828@2|Bacteria,1ZU81@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S21 - - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 CMS1_k127_5312622_12 861299.J421_3465 5.851e-39 150.0 COG0537@1|root,COG0537@2|Bacteria,1ZU0K@142182|Gemmatimonadetes 142182|Gemmatimonadetes FG HIT domain - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT CMS1_k127_5312622_3 861299.J421_3468 1.765e-133 435.0 COG0484@1|root,COG0484@2|Bacteria,1ZSVD@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG CMS1_k127_5312622_4 1379270.AUXF01000006_gene61 3.064e-114 385.0 COG1420@1|root,COG1420@2|Bacteria,1ZTER@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA CMS1_k127_5312622_5 861299.J421_3470 8.333e-111 373.0 COG0635@1|root,COG0635@2|Bacteria,1ZSSU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - Radical_SAM CMS1_k127_5312622_9 935948.KE386494_gene301 1.381e-65 250.0 COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,42FQZ@68295|Thermoanaerobacterales 186801|Clostridia L TIGRFAM DNA protecting protein DprA dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A CMS1_k127_5312622_2 861299.J421_3472 2.815e-135 439.0 COG0536@1|root,COG0536@2|Bacteria,1ZSVS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 CMS1_k127_5312622_8 215803.DB30_4629 2.357e-80 280.0 COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,42RKM@68525|delta/epsilon subdivisions,2WNVJ@28221|Deltaproteobacteria,2YX74@29|Myxococcales 28221|Deltaproteobacteria E L-asparaginase II - - - - - - - - - - - - Asparaginase_II CMS1_k127_5374636_41 1379270.AUXF01000006_gene290 6.923e-38 144.0 COG0322@1|root,COG0322@2|Bacteria,1ZSXE@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N CMS1_k127_5374636_10 861299.J421_3232 3.261e-128 420.0 COG0498@1|root,COG0498@2|Bacteria,1ZT17@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Pyridoxal-phosphate dependent enzyme - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_5374636_23 861299.J421_3233 3.088e-74 265.0 COG1641@1|root,COG1641@2|Bacteria 2|Bacteria H Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes larC - 4.99.1.12 ko:K06898,ko:K09121 - - - - ko00000,ko01000 - - - DUF111 CMS1_k127_5374636_54 1379270.AUXF01000002_gene1766 0.00013 54.0 COG4783@1|root,COG4783@2|Bacteria,1ZT4T@142182|Gemmatimonadetes 142182|Gemmatimonadetes S chaperone-mediated protein folding - - - - - - - - - - - - - CMS1_k127_5374636_5 379066.GAU_1600 1.34e-154 503.0 COG1625@1|root,COG1625@2|Bacteria,1ZSQ7@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF512) - - - - - - - - - - - - DUF512 CMS1_k127_5374636_11 1121423.JONT01000014_gene1242 2.038e-126 428.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,2602V@186807|Peptococcaceae 186801|Clostridia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 CMS1_k127_5374636_36 379066.GAU_1602 1.529e-40 165.0 COG0344@1|root,COG0344@2|Bacteria,1ZTTW@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf CMS1_k127_5374636_16 861299.J421_3237 4.913e-101 338.0 COG0240@1|root,COG0240@2|Bacteria,1ZTFK@142182|Gemmatimonadetes 142182|Gemmatimonadetes I NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N CMS1_k127_5374636_38 1379270.AUXF01000006_gene283 1.618e-39 159.0 COG0789@1|root,COG0789@2|Bacteria,1ZTSI@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 CMS1_k127_5374636_18 1379270.AUXF01000006_gene282 1.077e-96 325.0 COG0496@1|root,COG0496@2|Bacteria,1ZT6W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE CMS1_k127_5374636_28 861299.J421_3240 2.099e-65 232.0 COG2518@1|root,COG2518@2|Bacteria,1ZTED@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS1_k127_5374636_26 1125863.JAFN01000001_gene682 5.2e-68 237.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2WNP9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc CMS1_k127_5374636_50 240015.ACP_2872 3.707e-15 88.0 COG1254@1|root,COG1254@2|Bacteria,3Y55N@57723|Acidobacteria,2JJSV@204432|Acidobacteriia 204432|Acidobacteriia C Acylphosphatase - - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase CMS1_k127_5374636_35 379066.GAU_1611 1.371e-46 185.0 COG0253@1|root,COG0253@2|Bacteria,1ZU42@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan - - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase CMS1_k127_5374636_14 379066.GAU_1612 3.75e-116 377.0 COG0463@1|root,COG0463@2|Bacteria,1ZT31@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyltransferase like family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 CMS1_k127_5374636_7 1379270.AUXF01000004_gene2892 2.605e-146 492.0 COG4485@1|root,COG4485@2|Bacteria 2|Bacteria M Bacterial membrane protein, YfhO - - - - - - - - - - - - YfhO CMS1_k127_5374636_39 1379270.AUXF01000006_gene275 2.702e-39 161.0 COG0392@1|root,COG0392@2|Bacteria,1ZTX4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS1_k127_5374636_33 1379270.AUXF01000006_gene274 2.348e-49 190.0 COG0438@1|root,COG0438@2|Bacteria,1ZSTJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_5374636_19 1379270.AUXF01000006_gene273 4.729e-93 320.0 COG0463@1|root,COG0463@2|Bacteria,1ZTEI@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_5374636_2 861299.J421_3250 1.802e-169 564.0 COG1508@1|root,COG1508@2|Bacteria,1ZT13@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-54 factor, Activator interacting domain (AID) - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD CMS1_k127_5374636_9 861299.J421_3251 1.453e-129 439.0 COG1137@1|root,COG1137@2|Bacteria,1ZT4S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran CMS1_k127_5374636_40 861299.J421_3252 6.496e-39 166.0 2F01D@1|root,33T57@2|Bacteria,1ZTGK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5374636_46 861299.J421_3253 1.988e-26 121.0 2DWX3@1|root,342B9@2|Bacteria,1ZTXN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lipopolysaccharide-assembly, LptC-related - - - - - - - - - - - - LptC CMS1_k127_5374636_29 1379270.AUXF01000006_gene267 9.509e-53 198.0 COG1778@1|root,COG1778@2|Bacteria,1ZTTG@142182|Gemmatimonadetes 142182|Gemmatimonadetes S haloacid dehalogenase-like hydrolase - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 CMS1_k127_5374636_22 1121406.JAEX01000005_gene3071 1.546e-76 264.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2M90H@213115|Desulfovibrionales 28221|Deltaproteobacteria M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 CMS1_k127_5374636_0 861299.J421_3257 3.722e-258 811.0 COG0504@1|root,COG0504@2|Bacteria,1ZT0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase CMS1_k127_5374636_31 1379270.AUXF01000006_gene264 7.315e-51 189.0 COG1212@1|root,COG1212@2|Bacteria,1ZSRD@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 CMS1_k127_5374636_24 243231.GSU2382 1.131e-71 246.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,43TCX@69541|Desulfuromonadales 28221|Deltaproteobacteria EH TIGRFAM glutamine amidotransferase of anthranilate synthase trpG - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2496 GATase CMS1_k127_5374636_13 861299.J421_3262 6.795e-121 405.0 COG4974@1|root,COG4974@2|Bacteria,1ZTAH@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Phage integrase, N-terminal SAM-like domain xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase CMS1_k127_5374636_47 861299.J421_3263 1.437e-24 111.0 COG0586@1|root,COG0586@2|Bacteria,1ZTVI@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc CMS1_k127_5374636_34 379066.GAU_1631 7.361e-47 177.0 COG0245@1|root,COG0245@2|Bacteria,1ZTM5@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB CMS1_k127_5374636_25 1380350.JIAP01000009_gene5715 1.512e-70 246.0 COG3142@1|root,COG3142@2|Bacteria,1MV5W@1224|Proteobacteria,2TTKM@28211|Alphaproteobacteria,43KMZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Participates in the control of copper homeostasis cutC - - ko:K06201 - - - - ko00000 - - - CutC CMS1_k127_5374636_53 941824.TCEL_01381 1.634e-05 58.0 COG0296@1|root,COG0366@1|root,COG0296@2|Bacteria,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,36EQD@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 13 family - - - - - - - - - - - - AMPK1_CBM,Alpha-amylase,Alpha-amylase_N,Big_2,CBM_20,CBM_48,Cadherin-like,Malt_amylase_C,PUD,SLH CMS1_k127_5374636_52 1379270.AUXF01000001_gene2757 1.372e-05 57.0 28YSJ@1|root,2ZKJZ@2|Bacteria,1ZU1U@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5374636_49 1121439.dsat_2428 5.662e-17 93.0 COG0296@1|root,COG0296@2|Bacteria,1NEFK@1224|Proteobacteria,42VRH@68525|delta/epsilon subdivisions,2WRD5@28221|Deltaproteobacteria,2MC6U@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM glycoside hydrolase family 13 domain protein - - - - - - - - - - - - AMPK1_CBM CMS1_k127_5374636_43 861299.J421_2380 3.231e-31 137.0 COG1595@1|root,COG1595@2|Bacteria,1ZSWF@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_5374636_42 592015.HMPREF1705_00373 1.642e-35 140.0 COG0041@1|root,COG0041@2|Bacteria,3TB8R@508458|Synergistetes 508458|Synergistetes F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC CMS1_k127_5374636_4 1121468.AUBR01000030_gene1226 9.92e-157 504.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,42FCV@68295|Thermoanaerobacterales 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt CMS1_k127_5374636_45 861299.J421_3269 2.894e-27 112.0 COG0236@1|root,COG0236@2|Bacteria,1ZU0X@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding CMS1_k127_5374636_20 861299.J421_3270 5.567e-86 297.0 COG1028@1|root,COG1028@2|Bacteria,1ZT4H@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_5374636_21 861299.J421_3271 1.605e-84 304.0 COG0331@1|root,COG0331@2|Bacteria,1ZT40@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Acyl transferase domain - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 CMS1_k127_5374636_15 861299.J421_3272 9.617e-115 383.0 COG0332@1|root,COG0332@2|Bacteria,1ZSP4@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C CMS1_k127_5374636_17 861299.J421_3273 2.567e-97 328.0 COG0416@1|root,COG0416@2|Bacteria,1ZSN4@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis CMS1_k127_5374636_48 1133569.AHYZ01000040_gene1795 5.311e-19 87.0 COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,4HNIZ@91061|Bacilli 91061|Bacilli J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0003674,GO:0003735,GO:0005198 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p CMS1_k127_5374636_37 861299.J421_3275 3.575e-40 154.0 COG1399@1|root,COG1399@2|Bacteria,1ZTSW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Uncharacterized ACR, COG1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 CMS1_k127_5374636_32 379066.GAU_1643 5.997e-50 181.0 COG0105@1|root,COG0105@2|Bacteria,1ZTTD@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NDK - - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK CMS1_k127_5374636_30 861299.J421_3277 2.548e-51 203.0 COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria,1ZUGZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes GT Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - - - - - - - - - - CBS,PTS_EIIA_2 CMS1_k127_5374636_8 1379270.AUXF01000006_gene246 9.541e-132 426.0 COG0074@1|root,COG0074@2|Bacteria,1ZT20@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA CMS1_k127_5374636_3 1379270.AUXF01000006_gene245 1.436e-165 527.0 COG0045@1|root,COG0045@2|Bacteria,1ZSZ4@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA CMS1_k127_5374636_27 1449126.JQKL01000016_gene2871 1.102e-66 242.0 COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,267PQ@186813|unclassified Clostridiales 186801|Clostridia E Amino acid kinase family arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase CMS1_k127_5374636_44 1121385.AQXW01000004_gene1823 3.244e-28 133.0 COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,1ZWP7@145357|Dermacoccaceae 201174|Actinobacteria S Uncharacterised protein family (UPF0182) - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K09118 - - - - ko00000 - - - UPF0182 CMS1_k127_5374636_6 861299.J421_3281 8.854e-154 509.0 COG1109@1|root,COG1109@2|Bacteria,1ZSP6@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS1_k127_5374636_12 861299.J421_3282 1.086e-124 418.0 COG1007@1|root,COG1007@2|Bacteria,1ZSVJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M CMS1_k127_5374636_1 1379698.RBG1_1C00001G1061 6.81e-176 567.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M CMS1_k127_5374636_51 717231.Flexsi_0210 2.379e-14 76.0 COG1009@1|root,COG1009@2|Bacteria,2GEQE@200930|Deferribacteres 200930|Deferribacteres C NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N CMS1_k127_5390146_0 861299.J421_0531 1.18e-107 356.0 COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria 2|Bacteria S homoserine kinase activity gabT - 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - APH,Aminotran_3,Peptidase_M23 CMS1_k127_5390146_1 379066.GAU_0126 8.934e-07 60.0 2EY2H@1|root,33RBE@2|Bacteria,1ZTHK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5400371_0 1047013.AQSP01000097_gene1963 2.024e-89 316.0 COG2091@1|root,COG2091@2|Bacteria,2NQ9X@2323|unclassified Bacteria 2|Bacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 CMS1_k127_5400371_2 1429046.RR21198_4502 2.029e-24 108.0 COG3832@1|root,COG3832@2|Bacteria,2ISCU@201174|Actinobacteria,4G1QF@85025|Nocardiaceae 201174|Actinobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 CMS1_k127_5400371_3 394221.Mmar10_2053 3.651e-24 106.0 COG0640@1|root,COG0640@2|Bacteria,1N7VH@1224|Proteobacteria,2U72C@28211|Alphaproteobacteria,43YKG@69657|Hyphomonadaceae 28211|Alphaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor MA20_27670 - - - - - - - - - - - HTH_20,HTH_5 CMS1_k127_5400371_1 1122599.AUGR01000002_gene3440 2.08e-29 122.0 COG1280@1|root,COG1280@2|Bacteria,1RAI3@1224|Proteobacteria,1S2GP@1236|Gammaproteobacteria,1XJ9E@135619|Oceanospirillales 135619|Oceanospirillales E threonine efflux protein - - - - - - - - - - - - LysE CMS1_k127_5406647_5 1089544.KB912942_gene2155 4.731e-09 65.0 COG4994@1|root,COG4994@2|Bacteria,2ISVE@201174|Actinobacteria,4E603@85010|Pseudonocardiales 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS1_k127_5406647_0 404589.Anae109_4239 7.09e-129 431.0 COG0654@1|root,COG0654@2|Bacteria,1R03K@1224|Proteobacteria,43CQQ@68525|delta/epsilon subdivisions,2X7Y6@28221|Deltaproteobacteria,2Z1K0@29|Myxococcales 28221|Deltaproteobacteria CH FAD binding domain - - - - - - - - - - - - FAD_binding_3 CMS1_k127_5406647_2 1033743.CAES01000085_gene2957 1.285e-29 136.0 COG2730@1|root,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_17_28,CBM_2,CBM_3,CBM_6,Cellulase,F5_F8_type_C,Glyco_hydro_26,Glyco_hydro_8 CMS1_k127_5406647_4 509191.AEDB02000076_gene1482 8.566e-14 85.0 COG1705@1|root,COG4886@1|root,COG1705@2|Bacteria,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,24K2H@186801|Clostridia 186801|Clostridia E leucine-rich repeat-containing protein typical subtype - - - - - - - - - - - - DUF3888,FIVAR,LRR_4 CMS1_k127_5406647_1 1379270.AUXF01000002_gene1577 1.271e-62 236.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_5406647_3 452637.Oter_1898 4.16e-18 98.0 COG0577@1|root,COG0577@2|Bacteria 452637.Oter_1898|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_5418246_11 717606.PaecuDRAFT_2403 2.439e-05 57.0 COG5498@1|root,COG5498@2|Bacteria,1U7U3@1239|Firmicutes,4IT1H@91061|Bacilli,26SHU@186822|Paenibacillaceae 91061|Bacilli M glycoside hydrolase family 81 - - - - - - - - - - - - Glyco_hydro_81,fn3 CMS1_k127_5418246_1 518766.Rmar_1830 1.663e-202 650.0 COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes,1FK1K@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 CMS1_k127_5418246_12 1540221.JQNI01000004_gene184 3.017e-05 46.0 COG2267@1|root,COG2267@2|Bacteria,1WNCY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 CMS1_k127_5418246_4 479434.Sthe_0080 1.804e-102 347.0 COG0428@1|root,COG0428@2|Bacteria,2G671@200795|Chloroflexi,27YXX@189775|Thermomicrobia 189775|Thermomicrobia P ZIP Zinc transporter - - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - Zip CMS1_k127_5418246_13 56780.SYN_01247 0.0004832 49.0 2DCXT@1|root,2ZFR8@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5418246_5 234267.Acid_1797 9.765e-51 186.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4440,SnoaL_2,SnoaL_4 CMS1_k127_5418246_7 1379270.AUXF01000003_gene3588 1.333e-32 132.0 COG4103@1|root,COG4103@2|Bacteria 2|Bacteria T Tellurite resistance protein TerB - - - - - - - - - - - - TerB CMS1_k127_5418246_0 861299.J421_2136 9.736e-216 691.0 COG0405@1|root,COG0405@2|Bacteria,1ZUCB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS1_k127_5418246_8 379066.GAU_0906 3.625e-31 130.0 COG2839@1|root,COG2839@2|Bacteria,1ZUVE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF456) - - - ko:K09793 - - - - ko00000 - - - DUF456 CMS1_k127_5418246_3 414684.RC1_1736 8.469e-150 483.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2TT62@28211|Alphaproteobacteria,2JY7G@204441|Rhodospirillales 204441|Rhodospirillales I Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - - CMS1_k127_5418246_2 234267.Acid_3242 5.539e-176 579.0 COG0577@1|root,COG0577@2|Bacteria,3Y6E4@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_5418246_6 234267.Acid_4804 9.552e-41 156.0 COG2008@1|root,COG2008@2|Bacteria,3Y7Q8@57723|Acidobacteria 57723|Acidobacteria E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS1_k127_5433366_2 404589.Anae109_2205 3.97e-08 63.0 COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,42UKS@68525|delta/epsilon subdivisions,2WQV2@28221|Deltaproteobacteria 28221|Deltaproteobacteria T response regulator - - - ko:K15012 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg CMS1_k127_5433366_0 861299.J421_1172 3.321e-30 126.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_ECF,Sigma70_r2,Sigma70_r4,Sigma70_r4_2 CMS1_k127_5433366_3 1380390.JIAT01000009_gene1540 0.0001377 55.0 COG1653@1|root,COG1653@2|Bacteria,2HEVA@201174|Actinobacteria,4CTS1@84995|Rubrobacteria 84995|Rubrobacteria G Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1 CMS1_k127_5433366_1 1121094.KB894650_gene2457 4.435e-11 67.0 COG3391@1|root,COG3391@2|Bacteria,4PMVS@976|Bacteroidetes,2FSX5@200643|Bacteroidia,4AR6M@815|Bacteroidaceae 976|Bacteroidetes S TolB-like 6-blade propeller-like - - - - - - - - - - - - TolB_like CMS1_k127_5439414_1 671143.DAMO_2383 3.402e-253 787.0 COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria 2|Bacteria O FeS assembly protein SufB sufB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - ko:K07033,ko:K09014 - - - - ko00000 - - iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078 UPF0051 CMS1_k127_5439414_4 1348657.M622_02525 2.805e-110 363.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2VNGT@28216|Betaproteobacteria,2KXTH@206389|Rhodocyclales 206389|Rhodocyclales O COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran CMS1_k127_5439414_5 671143.DAMO_2381 1.327e-104 366.0 COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria 2|Bacteria O FeS assembly protein SufD sufD GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - ko:K07033,ko:K09015 - - - - ko00000 - - iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144 UPF0051 CMS1_k127_5439414_3 671143.DAMO_2380 1.738e-172 553.0 COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 CMS1_k127_5439414_7 671143.DAMO_2379 1.345e-47 191.0 COG0822@1|root,COG0822@2|Bacteria,2NPXN@2323|unclassified Bacteria 2|Bacteria C NifU-like N terminal domain nifU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - ko:K04488 - - - - ko00000 - - - NifU_N CMS1_k127_5439414_0 861299.J421_2007 2.506e-269 862.0 COG4262@1|root,COG4262@2|Bacteria,1ZU7C@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth CMS1_k127_5439414_2 886293.Sinac_1688 1.835e-217 682.0 COG3033@1|root,COG3033@2|Bacteria,2J41D@203682|Planctomycetes 203682|Planctomycetes E Beta-eliminating lyase - - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS1_k127_5439414_8 760192.Halhy_4503 5.169e-43 164.0 COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF1572) - - - - - - - - - - - - DUF1572 CMS1_k127_5439414_6 626887.J057_07416 9.186e-53 198.0 2DBAY@1|root,2Z84S@2|Bacteria,1R7V4@1224|Proteobacteria,1S1T1@1236|Gammaproteobacteria,469I4@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF1835) - - - - - - - - - - - - DUF1835 CMS1_k127_5448169_4 861299.J421_4543 1.356e-169 542.0 COG0183@1|root,COG0183@2|Bacteria,1ZSW1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thiolase, C-terminal domain - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N CMS1_k127_5448169_3 1379270.AUXF01000001_gene2467 6.893e-213 686.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1ZT1A@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Enoyl-CoA hydratase/isomerase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 CMS1_k127_5448169_6 861299.J421_4533 1.616e-102 346.0 COG0506@1|root,COG0506@2|Bacteria,1ZT6A@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh CMS1_k127_5448169_13 379066.GAU_2852 3.407e-12 78.0 2FDUV@1|root,345VG@2|Bacteria,1ZTXA@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5448169_8 1379270.AUXF01000001_gene2472 2.159e-68 244.0 COG1162@1|root,COG1162@2|Bacteria,1ZSSQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase CMS1_k127_5448169_9 469383.Cwoe_1920 5.923e-54 206.0 COG4198@1|root,COG4198@2|Bacteria,2GJFV@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 CMS1_k127_5448169_14 1379270.AUXF01000001_gene2507 4.256e-11 66.0 2FCBU@1|root,344FF@2|Bacteria,1ZU39@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5448169_16 522306.CAP2UW1_0625 5.533e-05 55.0 COG0457@1|root,COG0457@2|Bacteria,1RKBG@1224|Proteobacteria,2VQFW@28216|Betaproteobacteria 28216|Betaproteobacteria S Tetratricopeptide repeats - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 CMS1_k127_5448169_7 861299.J421_0555 4.131e-78 281.0 COG0793@1|root,COG0793@2|Bacteria,1ZT92@142182|Gemmatimonadetes 2|Bacteria M tail specific protease prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 CMS1_k127_5448169_0 379066.GAU_2797 8.2e-322 1001.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C CMS1_k127_5448169_5 861299.J421_4449 7.131e-124 419.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_5448169_1 649638.Trad_0459 8.825e-236 755.0 COG0466@1|root,COG0466@2|Bacteria,1WISX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C CMS1_k127_5448169_12 1121926.AXWO01000008_gene2990 7.673e-13 76.0 COG1309@1|root,COG1309@2|Bacteria,2IE9K@201174|Actinobacteria,4F01I@85014|Glycomycetales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS1_k127_5448169_15 588932.JHOF01000018_gene1037 1.514e-06 58.0 COG1378@1|root,COG1378@2|Bacteria,1N9ZU@1224|Proteobacteria,2U7Z9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Sugar-specific transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB CMS1_k127_5448169_10 1379270.AUXF01000001_gene2561 1.283e-53 206.0 2EW3S@1|root,33PH0@2|Bacteria,1ZTQG@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5448169_11 469371.Tbis_3279 9.984e-29 126.0 COG3386@1|root,COG3386@2|Bacteria,2GNAZ@201174|Actinobacteria,4DZHG@85010|Pseudonocardiales 201174|Actinobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - CMS1_k127_5448169_2 1121920.AUAU01000023_gene2395 2.481e-231 738.0 COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity leuD - 4.2.1.3,4.2.1.33,4.2.1.35 ko:K01681,ko:K01703,ko:K01704,ko:K17749 ko00020,ko00290,ko00400,ko00630,ko00660,ko00720,ko00966,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00400,map00630,map00660,map00720,map00966,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00432,M00535,M00740 R01324,R01325,R01900,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170,R10501 RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C CMS1_k127_5449974_2 1123242.JH636436_gene628 3.307e-107 353.0 COG1502@1|root,COG1502@2|Bacteria,2IY2H@203682|Planctomycetes 203682|Planctomycetes I Phospholipase_D-nuclease N-terminal - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N CMS1_k127_5449974_8 398767.Glov_0642 9.155e-11 68.0 COG4733@1|root,COG4733@2|Bacteria,1N010@1224|Proteobacteria,42M7U@68525|delta/epsilon subdivisions,2WRUR@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Fibronectin, type III domain - - - - - - - - - - - - fn3 CMS1_k127_5449974_3 861299.J421_1666 1.546e-92 342.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_5449974_5 690850.Desaf_2287 1.528e-78 272.0 COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,42QVG@68525|delta/epsilon subdivisions,2WNKA@28221|Deltaproteobacteria,2M9AG@213115|Desulfovibrionales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_5449974_0 518766.Rmar_1911 5.26e-146 481.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS1_k127_5449974_7 1121015.N789_04805 1.119e-26 114.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase CMS1_k127_5449974_6 861299.J421_6160 2.865e-66 235.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6160|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_5449974_1 941449.dsx2_0543 6.896e-125 405.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,42PJM@68525|delta/epsilon subdivisions,2WKJN@28221|Deltaproteobacteria,2M970@213115|Desulfovibrionales 28221|Deltaproteobacteria G Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 CMS1_k127_5449974_10 1121861.KB899914_gene2060 1.33e-07 63.0 COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,2TWGD@28211|Alphaproteobacteria,2JXDQ@204441|Rhodospirillales 204441|Rhodospirillales S NHL repeat - - - - - - - - - - - - NHL CMS1_k127_5449974_4 935845.JADQ01000068_gene1496 9.284e-80 286.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,4HB31@91061|Bacilli,26S2W@186822|Paenibacillaceae 91061|Bacilli EH Anthranilate synthase pabB GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 ko:K01665 ko00790,map00790 - R01716 RC00010,RC01418 ko00000,ko00001,ko01000 - - - Anth_synt_I_N,Chorismate_bind CMS1_k127_5449974_9 266117.Rxyl_0760 3.369e-10 72.0 COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria 201174|Actinobacteria EH Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 CMS1_k127_5451159_1 671143.DAMO_2812 5.398e-199 628.0 COG0372@1|root,COG0372@2|Bacteria,2NP9P@2323|unclassified Bacteria 2|Bacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt CMS1_k127_5451159_2 379066.GAU_0052 5.273e-139 473.0 COG2866@1|root,COG2866@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS1_k127_5451159_3 1267534.KB906762_gene1185 2.156e-85 312.0 COG0861@1|root,COG0861@2|Bacteria 2|Bacteria P Integral membrane protein TerC family terC - - - - - - - - - - - TerC CMS1_k127_5451159_4 379066.GAU_1210 2.358e-76 270.0 COG4409@1|root,COG4409@2|Bacteria,1ZUBR@142182|Gemmatimonadetes 142182|Gemmatimonadetes G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - - CMS1_k127_5451159_0 1379270.AUXF01000001_gene2380 6.143e-204 666.0 COG2366@1|root,COG2366@2|Bacteria,1ZT5C@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase CMS1_k127_5451159_7 1455608.JDTH01000006_gene2426 1.146e-41 164.0 COG1335@1|root,arCOG01943@2157|Archaea,2XWT4@28890|Euryarchaeota,23VDP@183963|Halobacteria 183963|Halobacteria Q COG1335 Amidases related to nicotinamidase - - - - - - - - - - - - Isochorismatase CMS1_k127_5451159_5 649638.Trad_2159 1.327e-64 245.0 COG1407@1|root,COG1407@2|Bacteria 2|Bacteria S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,Metallophos_2 CMS1_k127_5451159_8 309807.SRU_0062 5.161e-39 164.0 COG1073@1|root,COG1073@2|Bacteria,4NGCE@976|Bacteroidetes 976|Bacteroidetes S Hydrolase with alpha beta fold protein - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 CMS1_k127_5451159_6 283942.IL2328 4.353e-55 214.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,1RPRK@1236|Gammaproteobacteria,2QFR9@267893|Idiomarinaceae 1236|Gammaproteobacteria EU Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 CMS1_k127_5458366_6 1379270.AUXF01000005_gene449 1.26e-41 156.0 COG0577@1|root,COG0577@2|Bacteria,1ZUCK@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5458366_2 861299.J421_2896 1.303e-84 286.0 COG2120@1|root,COG2120@2|Bacteria,1ZTDK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S GlcNAc-PI de-N-acetylase - - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L CMS1_k127_5458366_5 1049564.TevJSym_aa00830 1.772e-56 204.0 COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,1S5B7@1236|Gammaproteobacteria,1J71P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 CMS1_k127_5458366_4 861299.J421_0787 1.263e-73 259.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS1_k127_5458366_3 861299.J421_0787 9.71e-78 270.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS1_k127_5458366_0 1379270.AUXF01000002_gene1600 4.241e-188 631.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_5458366_7 1379270.AUXF01000001_gene1947 2.864e-30 127.0 2BFKY@1|root,329F6@2|Bacteria,1ZV63@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5458366_1 1379270.AUXF01000002_gene1586 1.987e-162 544.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_5465647_0 1379270.AUXF01000002_gene1586 7.957e-81 287.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_5471582_0 330214.NIDE3591 3.782e-127 432.0 COG0744@1|root,COG0744@2|Bacteria,3J1FP@40117|Nitrospirae 40117|Nitrospirae M Transglycosylase - - 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase CMS1_k127_5471582_1 861299.J421_1717 5.362e-68 238.0 COG4232@1|root,COG4232@2|Bacteria,1ZSQP@142182|Gemmatimonadetes 142182|Gemmatimonadetes CO Cytochrome C biogenesis protein transmembrane region - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbD CMS1_k127_5481787_1 1191523.MROS_0480 6.404e-155 497.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria 2|Bacteria M serine-type peptidase activity - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ CMS1_k127_5481787_4 1047013.AQSP01000100_gene588 1.421e-103 349.0 COG3949@1|root,COG3949@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5481787_8 309807.SRU_0881 1.704e-20 102.0 2AB52@1|root,310J6@2|Bacteria,4PF3R@976|Bacteroidetes,1FK3A@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_5481787_3 1191523.MROS_0566 2.666e-114 382.0 COG1301@1|root,COG1301@2|Bacteria 2|Bacteria C dicarboxylic acid transport gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF CMS1_k127_5481787_0 861299.J421_5961 3.82e-216 685.0 COG1473@1|root,COG1473@2|Bacteria,1ZSTC@142182|Gemmatimonadetes 2|Bacteria S Peptidase dimerisation domain - - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 CMS1_k127_5481787_5 391603.FBALC1_05263 4.423e-90 310.0 COG0451@1|root,COG0451@2|Bacteria,4NX6A@976|Bacteroidetes,1IAM7@117743|Flavobacteriia 976|Bacteroidetes GM ADP-glyceromanno-heptose 6-epimerase activity - - - - - - - - - - - - Epimerase CMS1_k127_5481787_13 575540.Isop_0227 4.232e-06 59.0 COG0811@1|root,COG0811@2|Bacteria,2IZ3U@203682|Planctomycetes 203682|Planctomycetes U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB CMS1_k127_5481787_2 521045.Kole_1669 1.694e-129 425.0 COG1509@1|root,COG1509@2|Bacteria,2GC9P@200918|Thermotogae 200918|Thermotogae C Lysine 2,3-aminomutase YodO family protein - - - - - - - - - - - - Fer4_14,Radical_SAM CMS1_k127_5481787_6 357808.RoseRS_0493 2.992e-69 252.0 COG1651@1|root,COG4243@1|root,COG1651@2|Bacteria,COG4243@2|Bacteria,2G9QC@200795|Chloroflexi,3764Y@32061|Chloroflexia 32061|Chloroflexia CO PFAM Vitamin K epoxide reductase - - - - - - - - - - - - VKOR CMS1_k127_5481787_12 7739.XP_002600532.1 5.025e-07 62.0 KOG2177@1|root,KOG2177@2759|Eukaryota,38EA3@33154|Opisthokonta,3BFJH@33208|Metazoa,3CRTV@33213|Bilateria,47YXB@7711|Chordata 33208|Metazoa O zinc ion binding - - 2.3.2.27 ko:K11997,ko:K12021,ko:K12035 ko05206,map05206 - - - ko00000,ko00001,ko01000,ko03019,ko04121 - - - Filamin,NHL,zf-B_box,zf-C3HC4_3,zf-RING_2,zf-RING_UBOX CMS1_k127_5481787_7 443143.GM18_0593 5.749e-21 109.0 COG4733@1|root,COG4932@1|root,COG4733@2|Bacteria,COG4932@2|Bacteria,1RHT8@1224|Proteobacteria,430B7@68525|delta/epsilon subdivisions,2WVNE@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Fibronectin type 3 domain - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - - CMS1_k127_5481787_10 639282.DEFDS_0760 1.336e-10 75.0 COG3303@1|root,COG3303@2|Bacteria,2GG7G@200930|Deferribacteres 200930|Deferribacteres C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 CMS1_k127_5481787_11 635013.TherJR_2097 7.812e-09 67.0 COG3391@1|root,COG3391@2|Bacteria,1V2KS@1239|Firmicutes,24FSD@186801|Clostridia,263UX@186807|Peptococcaceae 186801|Clostridia S PFAM NHL repeat containing protein - - - - - - - - - - - - NHL CMS1_k127_5481787_9 404380.Gbem_2869 4.52e-17 96.0 COG3303@1|root,COG3880@1|root,COG3303@2|Bacteria,COG3880@2|Bacteria 2|Bacteria E PFAM UvrB UvrC protein mcsA GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 ko:K08999,ko:K19405,ko:K19411 - - R11090 RC00002,RC00203 ko00000,ko01000 - - - Cytochrom_CIII,Cytochrome_C7,UVR CMS1_k127_5505383_0 335543.Sfum_1471 7.554e-134 434.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,2MQ9F@213462|Syntrophobacterales 28221|Deltaproteobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 CMS1_k127_5522939_2 156889.Mmc1_3630 5.222e-142 461.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB CMS1_k127_5522939_0 861299.J421_3289 4.758e-189 605.0 COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria,1ZTDW@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3 CMS1_k127_5522939_3 861299.J421_3288 9.371e-118 392.0 COG1005@1|root,COG1005@2|Bacteria,1ZTDY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh CMS1_k127_5522939_4 1379270.AUXF01000006_gene237 8.183e-86 289.0 COG1143@1|root,COG1143@2|Bacteria,1ZTHB@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4_7 CMS1_k127_5522939_5 861299.J421_3286 1.536e-29 124.0 COG0839@1|root,COG0839@2|Bacteria,1ZTSA@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 CMS1_k127_5522939_6 861299.J421_3285 3.378e-27 113.0 COG0713@1|root,COG0713@2|Bacteria,1ZU00@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 CMS1_k127_5522939_1 861299.J421_3284 1.926e-178 571.0 COG1009@1|root,COG1009@2|Bacteria,1ZSZY@142182|Gemmatimonadetes 142182|Gemmatimonadetes CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N CMS1_k127_5528830_5 861299.J421_1414 9.33e-98 332.0 COG0577@1|root,COG0577@2|Bacteria,1ZUCK@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5528830_0 861299.J421_1415 6.538e-162 520.0 COG0577@1|root,COG0577@2|Bacteria,1ZUG3@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5528830_2 379066.GAU_1144 4.234e-117 396.0 COG0577@1|root,COG0577@2|Bacteria,1ZUN6@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5528830_1 379066.GAU_1145 6.247e-122 403.0 COG0577@1|root,COG0577@2|Bacteria,1ZUU2@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5528830_4 861299.J421_2902 9.137e-103 355.0 COG1136@1|root,COG1136@2|Bacteria,1ZSKH@142182|Gemmatimonadetes 142182|Gemmatimonadetes V membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_5528830_3 1379270.AUXF01000005_gene458 4.164e-107 362.0 COG0845@1|root,COG0845@2|Bacteria,1ZSX4@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 CMS1_k127_5528830_6 861299.J421_2904 8.258e-82 290.0 COG1538@1|root,COG1538@2|Bacteria,1ZSMB@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS1_k127_5528830_7 1089545.KB913037_gene175 1.458e-05 51.0 COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria,4EBWE@85010|Pseudonocardiales 201174|Actinobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS1_k127_5536205_2 861299.J421_2529 7.151e-129 421.0 COG0568@1|root,COG0568@2|Bacteria,1ZSNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 CMS1_k127_5536205_8 1442599.JAAN01000014_gene3524 1.045e-75 279.0 COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1X42C@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase CMS1_k127_5536205_11 330214.NIDE2777 1.381e-54 211.0 COG0384@1|root,COG0384@2|Bacteria 2|Bacteria S isomerase activity yddE - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF CMS1_k127_5536205_10 379066.GAU_0604 7.189e-55 216.0 COG2096@1|root,COG2096@2|Bacteria,1ZT4I@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans CMS1_k127_5536205_1 316274.Haur_3267 1.555e-154 511.0 COG0493@1|root,COG0493@2|Bacteria,2G6SR@200795|Chloroflexi,374Z6@32061|Chloroflexia 32061|Chloroflexia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - Pyr_redox_2 CMS1_k127_5536205_22 450851.PHZ_p0102 0.0006003 51.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2KF74@204458|Caulobacterales 204458|Caulobacterales O Belongs to the peptidase S1C family - - - - - - - - - - - - PDZ_2,Trypsin_2 CMS1_k127_5536205_3 861299.J421_2852 7.686e-113 399.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_2852|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_5536205_0 861299.J421_6223 6.811e-190 625.0 COG2091@1|root,COG2091@2|Bacteria,1ZUE3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - CMS1_k127_5536205_7 204669.Acid345_4495 2.343e-77 278.0 COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria,2JIBN@204432|Acidobacteriia 204432|Acidobacteriia M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 CMS1_k127_5536205_5 861299.J421_2544 2.717e-98 348.0 COG4775@1|root,COG4775@2|Bacteria,1ZSY7@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA CMS1_k127_5536205_4 379066.GAU_0609 1.652e-101 376.0 COG2911@1|root,COG2911@2|Bacteria,1ZT97@142182|Gemmatimonadetes 142182|Gemmatimonadetes S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB CMS1_k127_5536205_18 1150399.AQYK01000002_gene3647 1.002e-27 132.0 COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria,4FKAS@85023|Microbacteriaceae 201174|Actinobacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat CMS1_k127_5536205_6 861299.J421_2548 8.536e-89 305.0 COG3191@1|root,COG3191@2|Bacteria,1ZV5T@142182|Gemmatimonadetes 142182|Gemmatimonadetes EQ Peptidase family S58 - - - - - - - - - - - - Peptidase_S58 CMS1_k127_5536205_17 1249975.JQLP01000005_gene2407 2.376e-37 164.0 COG3188@1|root,COG3188@2|Bacteria,4NFPY@976|Bacteroidetes,1HXS8@117743|Flavobacteriia,2P5CG@244698|Gillisia 976|Bacteroidetes NU usher protein - - - - - - - - - - - - - CMS1_k127_5536205_16 379066.GAU_1023 5.773e-41 164.0 COG3121@1|root,COG3121@2|Bacteria 2|Bacteria NU pilus organization - - - - - - - - - - - - ASH,AhpC-TSA,Calx-beta,HemolysinCabind,LVIVD,PPC,PapD_N,Peptidase_S8 CMS1_k127_5536205_14 861299.J421_2552 9.398e-49 184.0 COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD CMS1_k127_5536205_13 349521.HCH_00225 5.497e-52 210.0 COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,1MZYN@1224|Proteobacteria,1RXX1@1236|Gammaproteobacteria,1XQQE@135619|Oceanospirillales 135619|Oceanospirillales E Zn_pept - - - - - - - - - - - - Peptidase_M14,Peptidase_M6 CMS1_k127_5536205_19 502558.EGYY_21810 5.974e-20 97.0 COG0736@1|root,COG0736@2|Bacteria,2HT7V@201174|Actinobacteria,4CVSA@84998|Coriobacteriia 84998|Coriobacteriia I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS CMS1_k127_5536205_12 861299.J421_3833 1.446e-54 201.0 COG0566@1|root,COG0566@2|Bacteria,1ZTVA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J RNA 2'-O ribose methyltransferase substrate binding - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind CMS1_k127_5536205_9 379066.GAU_2351 5.68e-60 216.0 COG1989@1|root,COG1989@2|Bacteria,1ZT9K@142182|Gemmatimonadetes 142182|Gemmatimonadetes NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 CMS1_k127_5536205_15 861299.J421_4375 2.475e-45 173.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_5538752_96 861299.J421_3520 4.534e-45 173.0 COG4464@1|root,COG4464@2|Bacteria,1ZTQH@142182|Gemmatimonadetes 142182|Gemmatimonadetes GM protein tyrosine phosphatase activity - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - - CMS1_k127_5538752_7 671143.DAMO_1329 2.221e-224 724.0 COG0013@1|root,COG0013@2|Bacteria,2NNYC@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD CMS1_k127_5538752_44 483219.LILAB_28140 1.747e-97 357.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions 1224|Proteobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Bac_luciferase,Condensation,PP-binding,Thioesterase CMS1_k127_5538752_121 1173028.ANKO01000086_gene4 1.032e-22 108.0 COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1HAPE@1150|Oscillatoriales 1117|Cyanobacteria H Belongs to the P-Pant transferase superfamily hetI GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS CMS1_k127_5538752_64 329726.AM1_0403 1.106e-68 241.0 COG1898@1|root,COG1898@2|Bacteria,1G0QA@1117|Cyanobacteria 1117|Cyanobacteria G Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom CMS1_k127_5538752_72 760568.Desku_0718 1.03e-60 235.0 COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,261FK@186807|Peptococcaceae 186801|Clostridia M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind CMS1_k127_5538752_38 760568.Desku_0719 5.275e-121 415.0 COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia,26192@186807|Peptococcaceae 186801|Clostridia M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS02615 GDP_Man_Dehyd CMS1_k127_5538752_36 489825.LYNGBM3L_08160 4.884e-127 418.0 COG1209@1|root,COG1209@2|Bacteria,1G091@1117|Cyanobacteria,1H9PI@1150|Oscillatoriales 1117|Cyanobacteria M Glucose-1-phosphate thymidylyltransferase rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase CMS1_k127_5538752_155 696747.NIES39_L00740 0.0001751 53.0 COG2755@1|root,COG2755@2|Bacteria,1G3Y8@1117|Cyanobacteria,1H8QZ@1150|Oscillatoriales 1117|Cyanobacteria E SGNH hydrolase-like domain, acetyltransferase AlgX - - - - - - - - - - - - ALGX CMS1_k127_5538752_112 388467.A19Y_0102 4.001e-30 138.0 COG2755@1|root,COG2755@2|Bacteria,1G3Y8@1117|Cyanobacteria,1H8QZ@1150|Oscillatoriales 1117|Cyanobacteria E SGNH hydrolase-like domain, acetyltransferase AlgX - - - - - - - - - - - - ALGX CMS1_k127_5538752_66 485913.Krac_3168 5.998e-67 248.0 COG3173@1|root,COG3173@2|Bacteria 2|Bacteria S very-long-chain-acyl-CoA dehydrogenase activity - - - - - - - - - - - - APH CMS1_k127_5538752_134 425104.Ssed_3004 2.356e-16 90.0 COG1874@1|root,COG1874@2|Bacteria,1QZBG@1224|Proteobacteria,1SE6Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Beta-galactosidase - - - - - - - - - - - - - CMS1_k127_5538752_35 690585.JNNU01000015_gene265 2.251e-131 437.0 COG2303@1|root,COG2303@2|Bacteria,1MUK2@1224|Proteobacteria,2U08V@28211|Alphaproteobacteria,4B7R3@82115|Rhizobiaceae 28211|Alphaproteobacteria E oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N CMS1_k127_5538752_140 351607.Acel_0725 3.57e-12 81.0 COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,2HTSQ@201174|Actinobacteria,4EU37@85013|Frankiales 201174|Actinobacteria M Glycosyltransferase like family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - - CMS1_k127_5538752_136 765910.MARPU_09180 7.447e-15 90.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,1RR2P@1236|Gammaproteobacteria,1WXP6@135613|Chromatiales 135613|Chromatiales O O-linked N-acetylglucosamine transferase, SPINDLY family - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 CMS1_k127_5538752_111 237368.SCABRO_00925 3.984e-30 135.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM CMS1_k127_5538752_93 671143.DAMO_0294 1.915e-47 190.0 COG0500@1|root,COG0535@1|root,COG0535@2|Bacteria,COG2226@2|Bacteria,2NPMF@2323|unclassified Bacteria 2|Bacteria Q Iron-sulfur cluster-binding domain - - - - - - - - - - - - Fer4_12,Methyltransf_11,Methyltransf_25,Radical_SAM,SPASM CMS1_k127_5538752_154 33876.JNXY01000025_gene5265 3.071e-05 56.0 COG1621@1|root,COG1621@2|Bacteria,2GKT1@201174|Actinobacteria,4DE1I@85008|Micromonosporales 201174|Actinobacteria G beta-fructofuranosidase activity - - - - - - - - - - - - - CMS1_k127_5538752_146 497965.Cyan7822_1657 7.876e-09 67.0 2E40H@1|root,32YXB@2|Bacteria,1GG4B@1117|Cyanobacteria,3KK33@43988|Cyanothece 1117|Cyanobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 CMS1_k127_5538752_120 869210.Marky_1948 5.888e-23 115.0 COG4221@1|root,COG4221@2|Bacteria,1WIDQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short CMS1_k127_5538752_62 1463903.JOIZ01000019_gene6638 3.212e-72 264.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C CMS1_k127_5538752_90 344747.PM8797T_27612 2.213e-49 183.0 COG0110@1|root,COG0110@2|Bacteria 2|Bacteria S O-acyltransferase activity - - - - - - - - - - - - Hexapep,Hexapep_2 CMS1_k127_5538752_97 324602.Caur_3656 1.844e-43 174.0 COG4992@1|root,COG4992@2|Bacteria,2G5SG@200795|Chloroflexi,375D1@32061|Chloroflexia 32061|Chloroflexia E Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine lysJ - - ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00031,M00763 R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_5538752_8 1123320.KB889668_gene3363 6.01e-222 734.0 COG3408@1|root,COG3408@2|Bacteria,2IA19@201174|Actinobacteria 201174|Actinobacteria G Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C CMS1_k127_5538752_123 405948.SACE_0653 1.205e-22 110.0 COG3510@1|root,COG3510@2|Bacteria,2I8ZG@201174|Actinobacteria,4DYRD@85010|Pseudonocardiales 201174|Actinobacteria V cephalosporin hydroxylase - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0030770,GO:0032259,GO:0044237,GO:0044249 - - - - - - - - - - Methyltransf_24 CMS1_k127_5538752_13 1123073.KB899243_gene829 4.68e-192 628.0 COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1MVIM@1224|Proteobacteria,1RPB8@1236|Gammaproteobacteria,1X3GZ@135614|Xanthomonadales 135614|Xanthomonadales M Glycosyl transferase - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glycos_transf_2 CMS1_k127_5538752_124 1054213.HMPREF9946_03053 1.219e-22 111.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups wcaC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K00754,ko:K13684 - - - - ko00000,ko01000,ko01003 - GT4 - DUF3880,Glyco_trans_1_2,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_5538752_56 1540221.JQNI01000002_gene1054 3.105e-80 288.0 COG1134@1|root,COG1134@2|Bacteria 2|Bacteria GM teichoic acid transport rfbB - 3.6.3.38,3.6.3.40 ko:K01990,ko:K09689,ko:K09691,ko:K09693 ko02010,map02010 M00249,M00250,M00251,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103,3.A.1.104 - - ABC_tran,Wzt_C CMS1_k127_5538752_69 91464.S7335_1337 3.447e-63 226.0 COG1682@1|root,COG1682@2|Bacteria,1G23R@1117|Cyanobacteria,1GZUH@1129|Synechococcus 1117|Cyanobacteria U transport, permease protein - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane CMS1_k127_5538752_37 1128421.JAGA01000003_gene3206 3.588e-122 406.0 COG0381@1|root,COG0381@2|Bacteria,2NNVT@2323|unclassified Bacteria 2|Bacteria M UDP-N-acetylglucosamine 2-epimerase wecB - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 CMS1_k127_5538752_126 1379270.AUXF01000004_gene3317 9.339e-22 111.0 COG1596@1|root,COG1596@2|Bacteria,1ZTXZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes M polysaccharide export - - - - - - - - - - - - SLBB CMS1_k127_5538752_6 861299.J421_3893 6.685e-240 758.0 COG0449@1|root,COG0449@2|Bacteria,1ZSTI@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS CMS1_k127_5538752_132 1173028.ANKO01000199_gene3588 2.388e-17 94.0 COG2199@1|root,COG3706@2|Bacteria,1G35Y@1117|Cyanobacteria 1117|Cyanobacteria T COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - 2.7.7.65 ko:K21020 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - GGDEF,Response_reg CMS1_k127_5538752_30 379066.GAU_0579 5.531e-141 477.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1ZSP0@142182|Gemmatimonadetes 142182|Gemmatimonadetes DM Chain length determinant protein - - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - GNVR CMS1_k127_5538752_16 1379270.AUXF01000004_gene3319 1.487e-178 581.0 COG2204@1|root,COG2204@2|Bacteria,1ZSZ6@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_5538752_74 861299.J421_2500 5.559e-58 216.0 COG0642@1|root,COG0642@2|Bacteria,1ZTZE@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA CMS1_k127_5538752_98 1232453.BAIF02000060_gene1731 1.853e-41 163.0 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,248WV@186801|Clostridia,26CKA@186813|unclassified Clostridiales 186801|Clostridia M Bacterial sugar transferase - - 2.7.8.6 ko:K00996 - - - - ko00000,ko01000,ko01005 - - - Bac_transf,CoA_binding_3 CMS1_k127_5538752_57 861299.J421_2477 2.336e-78 285.0 COG1269@1|root,COG1269@2|Bacteria,1ZT23@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transmembrane exosortase (Exosortase_EpsH) - - - - - - - - - - - - Exosortase_EpsH CMS1_k127_5538752_94 379066.GAU_0561 4.239e-47 186.0 COG1269@1|root,COG1269@2|Bacteria,1ZTKR@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF3485) - - - - - - - - - - - - DUF3485 CMS1_k127_5538752_83 861299.J421_2051 8.188e-53 203.0 COG1028@1|root,COG1028@2|Bacteria 861299.J421_2051|- IQ oxidoreductase activity, acting on CH-OH group of donors - - - - - - - - - - - - - CMS1_k127_5538752_15 864702.OsccyDRAFT_4169 4.462e-181 581.0 COG4976@1|root,COG4976@2|Bacteria,1GQBZ@1117|Cyanobacteria,1HHY0@1150|Oscillatoriales 1117|Cyanobacteria S Putative zinc binding domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 CMS1_k127_5538752_71 1173028.ANKO01000018_gene1166 2.5e-61 234.0 COG1898@1|root,COG1898@2|Bacteria,1G3DC@1117|Cyanobacteria,1HAPT@1150|Oscillatoriales 1117|Cyanobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose - - 1.1.1.133,5.1.3.13 ko:K00067,ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777,R06514 RC00182,RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom CMS1_k127_5538752_18 272134.KB731324_gene1965 8.466e-171 552.0 COG4310@1|root,COG4310@2|Bacteria,1G39N@1117|Cyanobacteria,1H9B5@1150|Oscillatoriales 1117|Cyanobacteria S winged helix-turn-helix - - - - - - - - - - - - DUF2172,DUF4910,HTH_47 CMS1_k127_5538752_34 869210.Marky_0739 5.469e-134 448.0 COG0451@1|root,COG0451@2|Bacteria,1WMCY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase CMS1_k127_5538752_41 272134.KB731324_gene1964 1.718e-113 373.0 COG1208@1|root,COG1208@2|Bacteria,1G4AN@1117|Cyanobacteria,1H8TU@1150|Oscillatoriales 1117|Cyanobacteria JM Nucleotidyl transferase - - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase CMS1_k127_5538752_60 414684.RC1_3995 8.828e-76 265.0 COG2120@1|root,COG2120@2|Bacteria,1MX2V@1224|Proteobacteria,2TT5F@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L CMS1_k127_5538752_63 1408224.SAMCCGM7_c3749 1.053e-68 255.0 COG2730@1|root,COG2730@2|Bacteria,1R544@1224|Proteobacteria,2U1MT@28211|Alphaproteobacteria,4BD0S@82115|Rhizobiaceae 28211|Alphaproteobacteria G Putative collagen-binding domain of a collagenase - - - - - - - - - - - - Collagen_bind_2,DUF4038 CMS1_k127_5538752_31 1234364.AMSF01000010_gene552 5.317e-138 456.0 2DBFX@1|root,2Z917@2|Bacteria,1P4PR@1224|Proteobacteria,1RWCW@1236|Gammaproteobacteria,1X36T@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - CMS1_k127_5538752_59 765869.BDW_10625 1.93e-76 271.0 COG1215@1|root,COG1215@2|Bacteria,1PGVQ@1224|Proteobacteria,43CVI@68525|delta/epsilon subdivisions,2MUGN@213481|Bdellovibrionales,2X2G5@28221|Deltaproteobacteria 213481|Bdellovibrionales M Glycosyl transferase family 21 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_5538752_58 497964.CfE428DRAFT_2188 1.498e-76 271.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_5538752_19 933262.AXAM01000035_gene2134 2.83e-166 545.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2MKAY@213118|Desulfobacterales 28221|Deltaproteobacteria E Asparagine synthase, glutamine-hydrolyzing asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS1_k127_5538752_70 448385.sce1301 2.02e-61 235.0 COG0438@1|root,COG0438@2|Bacteria,1R564@1224|Proteobacteria,42SAM@68525|delta/epsilon subdivisions,2WPCJ@28221|Deltaproteobacteria,2YZP2@29|Myxococcales 28221|Deltaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_5538752_133 1068978.AMETH_5131 3.109e-17 96.0 COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4DYAG@85010|Pseudonocardiales 201174|Actinobacteria E Asparagine synthase asnB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS1_k127_5538752_102 566461.SSFG_06905 3.698e-37 160.0 COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria 201174|Actinobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_5538752_67 1040989.AWZU01000028_gene3007 2.572e-65 244.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,3JR67@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH Acetolactate synthase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N CMS1_k127_5538752_107 1501230.ET33_18390 2.31e-33 138.0 COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,4HCJW@91061|Bacilli,26QKG@186822|Paenibacillaceae 91061|Bacilli G deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - LysM,Polysacc_deac_1 CMS1_k127_5538752_81 1254432.SCE1572_28200 3.441e-53 203.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42T55@68525|delta/epsilon subdivisions,2WPW2@28221|Deltaproteobacteria,2YY5H@29|Myxococcales 28221|Deltaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_5538752_127 1408433.JHXV01000019_gene1934 3.908e-21 110.0 COG2244@1|root,COG2244@2|Bacteria,4NDZ0@976|Bacteroidetes,1HWQF@117743|Flavobacteriia,2PADY@246874|Cryomorphaceae 976|Bacteroidetes S Membrane protein involved in the export of O-antigen and teichoic acid cap - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C CMS1_k127_5538752_105 211165.AJLN01000037_gene2059 1.245e-33 141.0 COG1216@1|root,COG1216@2|Bacteria,1G2ZC@1117|Cyanobacteria,1JHMP@1189|Stigonemataceae 1117|Cyanobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_5538752_84 383372.Rcas_3099 1.259e-51 198.0 COG1216@1|root,COG1216@2|Bacteria,2GB2A@200795|Chloroflexi,377SM@32061|Chloroflexia 32061|Chloroflexia S PFAM glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_5538752_82 225937.HP15_1904 5.442e-53 207.0 COG2327@1|root,COG2327@2|Bacteria,1R6AN@1224|Proteobacteria 1224|Proteobacteria S Polysaccharide pyruvyl transferase amsJ - - - - - - - - - - - PS_pyruv_trans CMS1_k127_5538752_109 861299.J421_4104 9.638e-33 147.0 COG5492@1|root,COG5492@2|Bacteria,1ZUE7@142182|Gemmatimonadetes 142182|Gemmatimonadetes N Bacterial Ig-like domain 2 - - - - - - - - - - - - Big_2 CMS1_k127_5538752_106 1120971.AUCA01000003_gene1465 2.034e-33 145.0 COG0438@1|root,COG0438@2|Bacteria,1V0G0@1239|Firmicutes,4HCG7@91061|Bacilli,27A3C@186823|Alicyclobacillaceae 91061|Bacilli M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS1_k127_5538752_122 861299.J421_4104 1.099e-22 113.0 COG5492@1|root,COG5492@2|Bacteria,1ZUE7@142182|Gemmatimonadetes 142182|Gemmatimonadetes N Bacterial Ig-like domain 2 - - - - - - - - - - - - Big_2 CMS1_k127_5538752_115 1234364.AMSF01000010_gene545 7.256e-28 129.0 COG3307@1|root,COG3307@2|Bacteria,1N4HJ@1224|Proteobacteria,1SWM6@1236|Gammaproteobacteria,1X57W@135614|Xanthomonadales 135614|Xanthomonadales M O-Antigen ligase - - - - - - - - - - - - Wzy_C CMS1_k127_5538752_153 644282.Deba_3075 6.152e-06 58.0 COG2755@1|root,COG2755@2|Bacteria 2|Bacteria E lipolytic protein G-D-S-L family - - - - - - - - - - - - Lipase_GDSL_2 CMS1_k127_5538752_141 945713.IALB_2722 4.57e-12 75.0 2EGPU@1|root,33AFZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5538752_151 203124.Tery_1684 4.447e-06 55.0 2DP8V@1|root,33122@2|Bacteria,1G83J@1117|Cyanobacteria,1HB8R@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS1_k127_5538752_2 861299.J421_6044 0.0 1009.0 COG2192@1|root,COG2192@2|Bacteria,1ZUTI@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N CMS1_k127_5538752_51 1158756.AQXQ01000011_gene703 2.542e-89 306.0 COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RREJ@1236|Gammaproteobacteria,1WWEV@135613|Chromatiales 135613|Chromatiales G polysaccharide deacetylase - - - - - - - - - - - - DUF3473,Polysacc_deac_1 CMS1_k127_5538752_156 313606.M23134_05022 0.0001888 54.0 COG1807@1|root,COG4642@1|root,COG1807@2|Bacteria,COG4642@2|Bacteria,4PME4@976|Bacteroidetes 976|Bacteroidetes M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - MORN CMS1_k127_5538752_149 443598.AUFA01000011_gene620 7.827e-07 60.0 COG1216@1|root,COG1216@2|Bacteria,1QUUA@1224|Proteobacteria,2U1P5@28211|Alphaproteobacteria,3JXT9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Glycosyl transferase family 21 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_1,Glycos_transf_2 CMS1_k127_5538752_11 861299.J421_0879 8.601e-202 639.0 COG1232@1|root,COG1232@2|Bacteria,1ZUPK@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase CMS1_k127_5538752_53 861299.J421_0878 5.783e-84 294.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 CMS1_k127_5538752_148 1198232.CYCME_1453 1.22e-07 59.0 COG1232@1|root,COG1232@2|Bacteria,1QX3T@1224|Proteobacteria,1T3RT@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase CMS1_k127_5538752_147 686578.AFFX01000001_gene1350 4.417e-08 64.0 COG2931@1|root,COG3210@1|root,COG4932@1|root,COG5295@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - 5_nucleotid_C,DUF4347,HemolysinCabind,Peptidase_M10_C CMS1_k127_5538752_114 379066.GAU_2577 8.697e-29 136.0 COG1629@1|root,COG4771@2|Bacteria,1ZSNG@142182|Gemmatimonadetes 142182|Gemmatimonadetes P CarboxypepD_reg-like domain - - - - - - - - - - - - CarboxypepD_reg,TonB_dep_Rec CMS1_k127_5538752_135 292459.STH1666 5.687e-15 84.0 COG2137@1|root,COG2137@2|Bacteria 2|Bacteria S regulation of DNA repair recX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03565 - - - - ko00000,ko03400 - - - RecX CMS1_k127_5538752_21 861299.J421_3527 1.435e-164 526.0 COG0468@1|root,COG0468@2|Bacteria,1ZT78@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA CMS1_k127_5538752_130 1120985.AUMI01000019_gene2274 1.095e-17 90.0 COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,4H5MB@909932|Negativicutes 909932|Negativicutes L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 CMS1_k127_5538752_12 1379270.AUXF01000006_gene38 2.672e-199 646.0 COG1674@1|root,COG1674@2|Bacteria,1ZSPI@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Ftsk_gamma - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma CMS1_k127_5538752_91 861299.J421_3532 5.232e-49 192.0 COG2045@1|root,COG2045@2|Bacteria,1ZTM8@142182|Gemmatimonadetes 142182|Gemmatimonadetes H 2-phosphosulpholactate phosphatase comB - 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp CMS1_k127_5538752_10 1379270.AUXF01000006_gene36 5.626e-216 677.0 COG0439@1|root,COG0439@2|Bacteria,1ZT0Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS1_k127_5538752_22 1379270.AUXF01000006_gene35 3.976e-157 505.0 COG2805@1|root,COG2805@2|Bacteria,1ZU8X@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS1_k127_5538752_104 379066.GAU_1925 9.495e-34 138.0 COG0511@1|root,COG0511@2|Bacteria,1ZTR1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA - - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl CMS1_k127_5538752_47 861299.J421_3535 1.695e-94 323.0 COG0006@1|root,COG0006@2|Bacteria,1ZSTY@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Creatinase/Prolidase N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 CMS1_k127_5538752_99 180281.CPCC7001_2498 7.052e-40 168.0 COG0757@1|root,COG0757@2|Bacteria,1GJQQ@1117|Cyanobacteria,22SQF@167375|Cyanobium 1117|Cyanobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II CMS1_k127_5538752_152 398767.Glov_1593 4.858e-06 60.0 COG4783@1|root,COG4783@2|Bacteria,1QZ64@1224|Proteobacteria,43CH3@68525|delta/epsilon subdivisions,2X7SA@28221|Deltaproteobacteria,43VYR@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_5538752_40 1379270.AUXF01000006_gene30 1.158e-114 392.0 COG0760@1|root,COG0760@2|Bacteria,1ZTD1@142182|Gemmatimonadetes 142182|Gemmatimonadetes O SurA N-terminal domain - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N_2 CMS1_k127_5538752_145 1185876.BN8_06679 9.142e-10 63.0 COG1826@1|root,COG1826@2|Bacteria,4NUNH@976|Bacteroidetes,47S09@768503|Cytophagia 976|Bacteroidetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 CMS1_k127_5538752_119 1379270.AUXF01000006_gene28 4.701e-23 103.0 2FH8C@1|root,3492Q@2|Bacteria,1ZTXE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4321) - - - - - - - - - - - - DUF4321 CMS1_k127_5538752_43 1379270.AUXF01000006_gene27 1.254e-104 349.0 COG0142@1|root,COG0142@2|Bacteria,1ZT7D@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Polyprenyl synthetase - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt CMS1_k127_5538752_65 1379270.AUXF01000006_gene26 1.275e-67 256.0 COG0457@1|root,COG0457@2|Bacteria,1ZU0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 CMS1_k127_5538752_42 861299.J421_3543 1.323e-106 371.0 COG1228@1|root,COG1228@2|Bacteria,1ZSNQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Amidohydrolase family hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_3 CMS1_k127_5538752_5 379066.GAU_1936 3.504e-272 867.0 COG2987@1|root,COG2987@2|Bacteria,1ZSQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N CMS1_k127_5538752_20 861299.J421_3546 5.907e-165 535.0 COG2986@1|root,COG2986@2|Bacteria,1ZTEG@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic CMS1_k127_5538752_144 1379698.RBG1_1C00001G1236 5.356e-10 71.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - ko:K06882 - - - - ko00000 - - - fn3 CMS1_k127_5538752_32 379066.GAU_1938 5.732e-137 480.0 COG1452@1|root,COG1452@2|Bacteria,1ZT14@142182|Gemmatimonadetes 142182|Gemmatimonadetes M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - CMS1_k127_5538752_87 861299.J421_3548 5.178e-51 209.0 COG0805@1|root,COG0805@2|Bacteria,1ZTHN@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC CMS1_k127_5538752_142 290318.Cvib_1161 1.627e-11 74.0 COG1729@1|root,COG1729@2|Bacteria,1FF3K@1090|Chlorobi 1090|Chlorobi S TIGRFAM tol-pal system protein YbgF - - - - - - - - - - - - TPR_6 CMS1_k127_5538752_108 379066.GAU_1941 5.145e-33 136.0 COG2885@1|root,COG2885@2|Bacteria,1ZTSM@142182|Gemmatimonadetes 142182|Gemmatimonadetes M OmpA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA CMS1_k127_5538752_52 1379270.AUXF01000006_gene17 5.592e-85 299.0 COG0823@1|root,COG0823@2|Bacteria,1ZTBK@142182|Gemmatimonadetes 142182|Gemmatimonadetes U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS1_k127_5538752_110 861299.J421_3552 9.478e-31 135.0 COG0810@1|root,COG0810@2|Bacteria,1ZTWX@142182|Gemmatimonadetes 142182|Gemmatimonadetes M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2 CMS1_k127_5538752_103 861299.J421_3553 1.894e-35 140.0 COG0848@1|root,COG0848@2|Bacteria,1ZTRS@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD CMS1_k127_5538752_88 861299.J421_3554 5.552e-51 197.0 COG0811@1|root,COG0811@2|Bacteria,1ZTBF@142182|Gemmatimonadetes 142182|Gemmatimonadetes U MotA/TolQ/ExbB proton channel family - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB CMS1_k127_5538752_45 861299.J421_3555 3.373e-97 327.0 COG1087@1|root,COG1087@2|Bacteria,1ZSX3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd CMS1_k127_5538752_137 589865.DaAHT2_0183 1.266e-12 80.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,42QS9@68525|delta/epsilon subdivisions,2WN3H@28221|Deltaproteobacteria,2MJ1W@213118|Desulfobacterales 28221|Deltaproteobacteria S Peptidoglycan-binding LysM - - - - - - - - - - - - LysM CMS1_k127_5538752_76 861299.J421_3557 2.537e-56 207.0 COG0629@1|root,COG0629@2|Bacteria,1ZTPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB CMS1_k127_5538752_113 861299.J421_3558 6.794e-29 123.0 COG0454@1|root,COG0456@2|Bacteria,1ZU09@142182|Gemmatimonadetes 142182|Gemmatimonadetes K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 CMS1_k127_5538752_125 546271.Selsp_0550 2.43e-22 107.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4H47Z@909932|Negativicutes 909932|Negativicutes O Universal bacterial protein YeaZ yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 CMS1_k127_5538752_131 379066.GAU_1952 1.643e-17 89.0 COG0802@1|root,COG0802@2|Bacteria,1ZTY0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - 2.7.1.221 ko:K06925,ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000,ko03016 - - - TsaE CMS1_k127_5538752_3 861299.J421_3561 7.262e-309 959.0 COG0556@1|root,COG0556@2|Bacteria,1ZSQS@142182|Gemmatimonadetes 142182|Gemmatimonadetes L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB CMS1_k127_5538752_4 861299.J421_3563 8.488e-277 880.0 COG0317@1|root,COG0317@2|Bacteria,1ZT5M@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS CMS1_k127_5538752_61 379066.GAU_1956 1.854e-72 252.0 COG2003@1|root,COG2003@2|Bacteria,1ZTFU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E RadC-like JAB domain - - - ko:K03630 - - - - ko00000 - - - RadC CMS1_k127_5538752_1 1379270.AUXF01000003_gene3895 0.0 1232.0 COG0653@1|root,COG0653@2|Bacteria,1ZSMK@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW CMS1_k127_5538752_95 471853.Bcav_1634 5.243e-46 172.0 COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like CMS1_k127_5538752_100 861299.J421_3568 1.047e-37 162.0 COG4105@1|root,COG4105@2|Bacteria,1ZTMC@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Outer membrane lipoprotein - - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO CMS1_k127_5538752_116 1125863.JAFN01000001_gene1608 1.24e-27 123.0 COG0457@1|root,COG0457@2|Bacteria,1N5BD@1224|Proteobacteria,42U63@68525|delta/epsilon subdivisions,2WQUR@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TPR repeat - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8 CMS1_k127_5538752_46 1232410.KI421415_gene3062 2.505e-96 337.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MWH@68525|delta/epsilon subdivisions,2WJMZ@28221|Deltaproteobacteria,43U74@69541|Desulfuromonadales 28221|Deltaproteobacteria M Polysaccharide biosynthesis protein uge - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd CMS1_k127_5538752_24 861299.J421_0145 1.91e-155 500.0 COG0451@1|root,COG0451@2|Bacteria,1ZUJJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes GM 3-beta hydroxysteroid dehydrogenase/isomerase family - - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd CMS1_k127_5538752_17 861299.J421_0144 7.841e-174 576.0 COG1004@1|root,COG1004@2|Bacteria,1ZTH3@142182|Gemmatimonadetes 2|Bacteria M UDP binding domain ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N CMS1_k127_5538752_14 861299.J421_3569 1.045e-183 583.0 COG0677@1|root,COG0677@2|Bacteria,1ZT42@142182|Gemmatimonadetes 142182|Gemmatimonadetes M UDP binding domain - - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N CMS1_k127_5538752_49 1183438.GKIL_0479 9.273e-92 317.0 COG0673@1|root,COG0673@2|Bacteria,1G1CZ@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA CMS1_k127_5538752_27 861299.J421_3570 1.126e-145 469.0 COG0399@1|root,COG0399@2|Bacteria,1ZT81@142182|Gemmatimonadetes 142182|Gemmatimonadetes M DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 CMS1_k127_5538752_55 515635.Dtur_0577 2.351e-82 279.0 COG0110@1|root,COG0110@2|Bacteria 2|Bacteria S O-acyltransferase activity wbpD - 2.3.1.201 ko:K13018 ko00520,map00520 - R10100 RC00004,RC00166 ko00000,ko00001,ko01000,ko01005 - - - GFO_IDH_MocA,Hexapep,Hexapep_2 CMS1_k127_5538752_68 502558.EGYY_12820 1.281e-64 236.0 COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4CUE7@84998|Coriobacteriia 84998|Coriobacteriia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C CMS1_k127_5538752_0 861299.J421_3571 0.0 1590.0 COG0458@1|root,COG0458@2|Bacteria,1ZSPK@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS CMS1_k127_5538752_85 1278073.MYSTI_05892 2.828e-51 193.0 COG1089@1|root,COG1089@2|Bacteria,1QXV3@1224|Proteobacteria,4347Z@68525|delta/epsilon subdivisions,2X7I2@28221|Deltaproteobacteria,2YXC2@29|Myxococcales 28221|Deltaproteobacteria M Polysaccharide biosynthesis protein - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd CMS1_k127_5538752_23 1379270.AUXF01000003_gene3886 3.298e-156 499.0 COG1089@1|root,COG1089@2|Bacteria,1ZSR1@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd CMS1_k127_5538752_118 796940.HMPREF9628_00853 2.815e-24 103.0 COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia 186801|Clostridia J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 CMS1_k127_5538752_101 861299.J421_3575 1.312e-37 144.0 COG0203@1|root,COG0203@2|Bacteria,1ZTPM@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 CMS1_k127_5538752_33 861299.J421_3576 5.2e-135 439.0 COG0202@1|root,COG0202@2|Bacteria,1ZTEV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L CMS1_k127_5538752_50 861299.J421_3577 3.769e-91 303.0 COG0522@1|root,COG0522@2|Bacteria,1ZTGJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 CMS1_k127_5538752_75 861299.J421_3578 1.286e-56 199.0 COG0100@1|root,COG0100@2|Bacteria,1ZTMZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 CMS1_k127_5538752_79 861299.J421_3579 1.881e-54 194.0 COG0099@1|root,COG0099@2|Bacteria,1ZTNX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 CMS1_k127_5538752_139 379066.GAU_1977 2.132e-12 74.0 COG0257@1|root,COG0257@2|Bacteria,1ZVAA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L36 rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 CMS1_k127_5538752_92 742742.HMPREF9452_00253 1.107e-47 182.0 COG0284@1|root,COG0284@2|Bacteria,2IPX2@201174|Actinobacteria,4CV9H@84998|Coriobacteriia 84998|Coriobacteriia F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase CMS1_k127_5538752_54 861299.J421_3582 6.61e-84 299.0 COG0167@1|root,COG0167@2|Bacteria,1ZT86@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh CMS1_k127_5538752_73 861299.J421_3583 3.839e-60 229.0 COG0860@1|root,COG0860@2|Bacteria,1ZSUX@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 CMS1_k127_5538752_86 861299.J421_3584 4.382e-51 185.0 COG0691@1|root,COG0691@2|Bacteria,1ZTQN@142182|Gemmatimonadetes 142182|Gemmatimonadetes J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB CMS1_k127_5538752_29 1303518.CCALI_00532 5.924e-143 462.0 COG0476@1|root,COG0607@1|root,COG1977@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,COG1977@2|Bacteria 2|Bacteria H Mo-molybdopterin cofactor metabolic process moeB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.73,2.7.7.80,2.8.1.11 ko:K03148,ko:K03636,ko:K21029,ko:K21147 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF,ThiS CMS1_k127_5538752_89 379066.GAU_1983 6.007e-51 184.0 COG1959@1|root,COG1959@2|Bacteria,1ZTRG@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulator - - - - - - - - - - - - Rrf2 CMS1_k127_5538752_77 649638.Trad_0407 1.81e-55 201.0 COG0491@1|root,COG0491@2|Bacteria,1WIMP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - - - - - - - - - - Lactamase_B CMS1_k127_5538752_48 1123284.KB899045_gene2557 2.031e-94 319.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,4HA4N@91061|Bacilli,26NMP@186821|Sporolactobacillaceae 91061|Bacilli C FAD dependent oxidoreductase trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_5538752_78 861299.J421_3591 6.976e-55 205.0 COG1028@1|root,COG1028@2|Bacteria,1ZTNC@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ KR domain - - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 CMS1_k127_5538752_143 882083.SacmaDRAFT_1425 2.317e-11 67.0 COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4E2X5@85010|Pseudonocardiales 201174|Actinobacteria O PFAM AhpC TSA family ahpE GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - AhpC-TSA CMS1_k127_5538752_150 517418.Ctha_1325 8.711e-07 60.0 COG1225@1|root,COG1225@2|Bacteria,1FF7K@1090|Chlorobi 1090|Chlorobi O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA CMS1_k127_5538752_80 861299.J421_3592 3.79e-54 201.0 COG0613@1|root,COG0613@2|Bacteria,1ZTHM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DNA polymerase alpha chain like domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP CMS1_k127_5538752_128 861299.J421_3593 3.905e-20 95.0 2FHQX@1|root,349IG@2|Bacteria,1ZU2X@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5538752_26 861299.J421_3595 4.578e-148 481.0 COG0508@1|root,COG0508@2|Bacteria,1ZT7I@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) - - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding CMS1_k127_5538752_25 861299.J421_3597 2.637e-153 494.0 COG0022@1|root,COG0022@2|Bacteria,1ZT89@142182|Gemmatimonadetes 2|Bacteria C Transketolase, pyrimidine binding domain bfmBA - 1.2.4.4 ko:K00167,ko:K11381,ko:K21417 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C CMS1_k127_5538752_39 861299.J421_3598 1.436e-118 396.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 2|Bacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) bfmBA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C CMS1_k127_5538752_157 1236504.HMPREF2132_03300 0.0002986 49.0 COG2608@1|root,COG2608@2|Bacteria,4PBRB@976|Bacteroidetes,2FZDQ@200643|Bacteroidia 976|Bacteroidetes P Heavy metal-associated domain protein - - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA CMS1_k127_5538752_129 379066.GAU_1995 7.857e-20 92.0 2FD8C@1|root,345AC@2|Bacteria,1ZTXK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5538752_9 351160.RCIX1517 2.885e-221 716.0 COG2217@1|root,arCOG02763@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia 224756|Methanomicrobia P ATPase, P-type (transporting), HAD superfamily, subfamily IC copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase CMS1_k127_5538752_117 469371.Tbis_2120 1.157e-24 117.0 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4EAKI@85010|Pseudonocardiales 201174|Actinobacteria P Cupredoxin-like domain - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS CMS1_k127_5538752_28 861299.J421_3601 1.574e-144 461.0 COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 CMS1_k127_5566577_0 1121920.AUAU01000012_gene2631 1.381e-78 291.0 COG1629@1|root,COG4771@2|Bacteria,3Y3ZU@57723|Acidobacteria 57723|Acidobacteria P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec CMS1_k127_5566577_1 861299.J421_1280 1.143e-36 159.0 COG0515@1|root,COG3629@1|root,COG0515@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 2|Bacteria T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS1_k127_5586551_11 1379270.AUXF01000004_gene3168 3.918e-42 170.0 2DBB2@1|root,2Z858@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5586551_9 1379270.AUXF01000004_gene3167 8.484e-69 247.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - CMS1_k127_5586551_12 880073.Calab_2383 8.469e-41 164.0 COG0739@1|root,COG0739@2|Bacteria,2NPG3@2323|unclassified Bacteria 2|Bacteria M Peptidase family M23 - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 CMS1_k127_5586551_2 379066.GAU_0734 5.701e-164 532.0 COG0143@1|root,COG0143@2|Bacteria,1ZTDB@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (M) - - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g CMS1_k127_5586551_6 861299.J421_2654 1.154e-99 336.0 COG1774@1|root,COG1774@2|Bacteria,1ZTE8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S PSP1 C-terminal conserved region - - - - - - - - - - - - PSP1 CMS1_k127_5586551_5 379066.GAU_0736 3.123e-120 394.0 COG0825@1|root,COG0825@2|Bacteria,1ZSW6@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA CMS1_k127_5586551_0 861299.J421_2656 0.0 1371.0 COG0587@1|root,COG0587@2|Bacteria,1ZT8N@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Helix-hairpin-helix motif - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP CMS1_k127_5586551_7 861299.J421_2657 4.564e-90 323.0 COG5492@1|root,COG5492@2|Bacteria,1ZSW8@142182|Gemmatimonadetes 2|Bacteria N domain, Protein - - 3.2.1.4,3.4.17.14 ko:K01179,ko:K07260,ko:K13735 ko00500,ko00550,ko01100,ko01502,ko02020,ko05100,map00500,map00550,map01100,map01502,map02020,map05100 M00651 R06200,R11307,R11308 - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - GH5,GH9 - Big_1,Big_2,Glug,IAT_beta,Invasin_D3,LysM,Mfa_like_1,SLH CMS1_k127_5586551_10 861299.J421_2658 1.194e-63 241.0 COG4324@1|root,COG4324@2|Bacteria,1ZT8G@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative aminopeptidase - - - - - - - - - - - - Aminopep CMS1_k127_5586551_4 1121920.AUAU01000031_gene1411 3.478e-129 426.0 COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria 57723|Acidobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - - - - - - - - - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_5586551_3 1382359.JIAL01000001_gene2221 1.302e-133 450.0 COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria,2JIUW@204432|Acidobacteriia 204432|Acidobacteriia E PFAM peptidase - - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS1_k127_5586551_8 861299.J421_2661 9.122e-78 267.0 COG0321@1|root,COG0321@2|Bacteria,1ZTM1@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB CMS1_k127_5586551_1 379066.GAU_0745 1.95e-184 586.0 COG1249@1|root,COG1249@2|Bacteria,1ZT95@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim CMS1_k127_5603934_5 1267535.KB906767_gene4724 3.425e-62 226.0 COG0577@1|root,COG0577@2|Bacteria 1267535.KB906767_gene4724|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_5603934_0 861299.J421_6227 2.211e-189 620.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_5603934_4 861299.J421_4099 2.531e-97 348.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_4099|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_5603934_1 861299.J421_1128 4.252e-177 585.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_5603934_3 234267.Acid_6481 1.388e-109 359.0 COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria 57723|Acidobacteria V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_5603934_2 215803.DB30_8372 1.482e-120 399.0 COG0845@1|root,COG0845@2|Bacteria,1R50D@1224|Proteobacteria,438S0@68525|delta/epsilon subdivisions,2X3YT@28221|Deltaproteobacteria,2YXMR@29|Myxococcales 28221|Deltaproteobacteria M Biotin-lipoyl like - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 CMS1_k127_5633989_0 529884.Rhola_00012780 2.179e-219 769.0 COG2911@1|root,COG3210@1|root,COG3637@1|root,COG4412@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3637@2|Bacteria,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - 2.7.11.1 ko:K07004,ko:K09955,ko:K12567,ko:K21449 ko05410,ko05414,map05410,map05414 - - - ko00000,ko00001,ko01000,ko01001,ko02000,ko04131,ko04147,ko04812 1.B.40.2 - - DctA-YdbH,Laminin_G_3,OMP_b-brl CMS1_k127_5633989_5 316067.Geob_1791 7.346e-09 72.0 COG1470@1|root,COG3391@1|root,COG4733@1|root,COG5492@1|root,COG1470@2|Bacteria,COG3391@2|Bacteria,COG4733@2|Bacteria,COG5492@2|Bacteria,1QWRQ@1224|Proteobacteria 1224|Proteobacteria M 6-phosphogluconolactonase activity - - - - - - - - - - - - ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS CMS1_k127_5633989_3 1111069.TCCBUS3UF1_4090 6.624e-163 542.0 COG0427@1|root,COG0427@2|Bacteria,1WJIT@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro CMS1_k127_5633989_4 945713.IALB_2183 8.417e-87 317.0 COG0686@1|root,COG0686@2|Bacteria 2|Bacteria E alanine dehydrogenase activity ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N CMS1_k127_5633989_1 1121920.AUAU01000021_gene2510 1.58e-198 630.0 COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,3Y3G3@57723|Acidobacteria 57723|Acidobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.7 ko:K00187 ko00280,ko01100,map00280,map01100 - R07160,R08566,R08567 RC00004,RC02833,RC02856 br01601,ko00000,ko00001,ko01000 - - - POR,TPP_enzyme_C CMS1_k127_5633989_2 1121920.AUAU01000021_gene2509 6.142e-198 630.0 COG0674@1|root,COG0674@2|Bacteria,3Y3NB@57723|Acidobacteria 57723|Acidobacteria C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.7 ko:K00186 ko00280,ko01100,map00280,map01100 - R07160,R08566,R08567 RC00004,RC02833,RC02856 br01601,ko00000,ko00001,ko01000 - - - PFOR_II,POR_N CMS1_k127_5641808_9 1211114.ALIP01000021_gene83 1.761e-46 184.0 2DNF6@1|root,32X6Q@2|Bacteria,1R2P4@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_5641808_8 247490.KSU1_D0551 9.682e-48 184.0 28MCN@1|root,2ZAQR@2|Bacteria,2J327@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS1_k127_5641808_10 929713.NIASO_00445 2.566e-46 184.0 2BXDT@1|root,2ZKKS@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5641808_5 1121405.dsmv_3027 1.798e-77 272.0 COG3016@1|root,COG3016@2|Bacteria,1QHS4@1224|Proteobacteria,4315A@68525|delta/epsilon subdivisions,2WW96@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Haem-binding uptake, Tiki superfamily, ChaN - - - - - - - - - - - - Cofac_haem_bdg CMS1_k127_5641808_3 518766.Rmar_1357 8.008e-113 380.0 COG1680@1|root,COG1680@2|Bacteria,4NJ0F@976|Bacteroidetes 976|Bacteroidetes V Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase CMS1_k127_5641808_2 1206732.BAGD01000074_gene2933 1.457e-121 430.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4FX0N@85025|Nocardiaceae 201174|Actinobacteria GT Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.1,2.7.9.2 ko:K01006,ko:K01007 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N CMS1_k127_5641808_12 592010.GCWU000182_000328 3.483e-10 73.0 COG0382@1|root,COG0382@2|Bacteria,1TR4B@1239|Firmicutes,4HF3A@91061|Bacilli 91061|Bacilli H UbiA prenyltransferase family ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA CMS1_k127_5641808_7 1112212.JH584235_gene1372 4.183e-63 232.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,2TUU2@28211|Alphaproteobacteria,2K0BS@204457|Sphingomonadales 204457|Sphingomonadales K acetyltransferase - - - - - - - - - - - - - CMS1_k127_5641808_4 243231.GSU0204 2.887e-92 320.0 COG1032@1|root,COG1032@2|Bacteria,1R92G@1224|Proteobacteria,42RM5@68525|delta/epsilon subdivisions,2WNP2@28221|Deltaproteobacteria 28221|Deltaproteobacteria C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM CMS1_k127_5641808_0 927677.ALVU02000001_gene2236 1.136e-161 528.0 COG0477@1|root,COG0477@2|Bacteria,1G155@1117|Cyanobacteria 1117|Cyanobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 CMS1_k127_5641808_6 1121104.AQXH01000001_gene1901 1.827e-70 264.0 COG2866@1|root,COG2866@2|Bacteria,4NHBS@976|Bacteroidetes,1IV9B@117747|Sphingobacteriia 976|Bacteroidetes E Zn_pept - - - - - - - - - - - - Peptidase_M14 CMS1_k127_5641808_1 1267211.KI669560_gene1831 1.475e-131 456.0 COG2866@1|root,COG2866@2|Bacteria,4NH4I@976|Bacteroidetes,1IVQ3@117747|Sphingobacteriia 976|Bacteroidetes M Zn_pept - - - - - - - - - - - - Peptidase_M14 CMS1_k127_5641808_11 1396141.BATP01000003_gene4881 1.43e-43 170.0 COG3568@1|root,COG3568@2|Bacteria,46X7C@74201|Verrucomicrobia,2IUUK@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos CMS1_k127_5641808_13 1550073.JROH01000028_gene881 1.129e-09 63.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2U29S@28211|Alphaproteobacteria,2K2EB@204457|Sphingomonadales 204457|Sphingomonadales S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - - - - - - - - - - PepX_C,Peptidase_S15 CMS1_k127_5647795_11 1229780.BN381_310069 5.139e-09 57.0 COG0584@1|root,COG0584@2|Bacteria 2|Bacteria C glycerophosphodiester phosphodiesterase activity - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD CMS1_k127_5647795_5 404589.Anae109_0223 1.009e-38 149.0 COG4914@1|root,COG4914@2|Bacteria,1N1W1@1224|Proteobacteria,42VPD@68525|delta/epsilon subdivisions,2WS3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_5647795_4 439235.Dalk_1739 7.135e-66 243.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,42ZTX@68525|delta/epsilon subdivisions,2WVID@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - iAF987.Gmet_2224 ECH_1 CMS1_k127_5647795_1 562970.Btus_1243 3.045e-142 486.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,277YV@186823|Alicyclobacillaceae 91061|Bacilli I Belongs to the thiolase family pcaF - 2.3.1.174,2.3.1.223,2.3.1.9 ko:K00626,ko:K02615 ko00071,ko00072,ko00280,ko00310,ko00360,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00360,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R00829,R01177,R09839 RC00004,RC00326,RC03003 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_5647795_0 1379698.RBG1_1C00001G0805 2.727e-163 540.0 COG1012@1|root,COG1012@2|Bacteria,2NNWB@2323|unclassified Bacteria 2|Bacteria C Belongs to the aldehyde dehydrogenase family aldH - 1.2.1.3 ko:K00128,ko:K00138 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS1_k127_5647795_2 1379698.RBG1_1C00001G0806 2.019e-123 400.0 COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria 2|Bacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 CMS1_k127_5647795_12 1118054.CAGW01000061_gene2431 9.877e-06 54.0 2DFWV@1|root,2ZTI9@2|Bacteria,1W53S@1239|Firmicutes,4HZK2@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - CMS1_k127_5647795_8 1382306.JNIM01000001_gene267 8.026e-29 126.0 COG3396@1|root,COG3396@2|Bacteria,2G9KQ@200795|Chloroflexi 200795|Chloroflexi S PFAM phenylacetic acid catabolic family protein - - 1.14.13.149 ko:K02611 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001,ko01000 - - - PaaA_PaaC CMS1_k127_5647795_10 1198232.CYCME_2337 2.49e-12 72.0 COG3460@1|root,COG3460@2|Bacteria,1ND92@1224|Proteobacteria 1224|Proteobacteria Q Phenylacetic acid degradation B - - - - - - - - - - - - PaaB CMS1_k127_5647795_9 1230457.C476_08148 2.162e-26 111.0 COG2151@1|root,arCOG01845@2157|Archaea,2Y0P6@28890|Euryarchaeota,23W2A@183963|Halobacteria 183963|Halobacteria S metal-sulfur cluster biosynthetic enzyme - - - - - - - - - - - - FeS_assembly_P CMS1_k127_5647795_3 266117.Rxyl_1756 7.23e-117 384.0 COG3396@1|root,COG3396@2|Bacteria,2GMQ3@201174|Actinobacteria,4CQIA@84995|Rubrobacteria 84995|Rubrobacteria S phenylacetic acid catabolic - - 1.14.13.149 ko:K02609 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001,ko01000 - - - PaaA_PaaC CMS1_k127_5647795_7 1125863.JAFN01000001_gene2929 3.508e-32 133.0 COG1309@1|root,COG1309@2|Bacteria,1N9ZB@1224|Proteobacteria,42VC2@68525|delta/epsilon subdivisions,2WRA9@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS1_k127_5647795_6 379066.GAU_1695 3.29e-33 135.0 COG1595@1|root,COG1595@2|Bacteria,1ZTKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_5647795_13 1379270.AUXF01000006_gene198 4.934e-05 54.0 297VI@1|root,2ZV24@2|Bacteria,1ZU61@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5650842_15 443144.GM21_0405 2.826e-09 63.0 COG1648@1|root,COG1648@2|Bacteria,1RB3H@1224|Proteobacteria,42QT2@68525|delta/epsilon subdivisions,2WN1F@28221|Deltaproteobacteria,43UXX@69541|Desulfuromonadales 28221|Deltaproteobacteria H Sirohaem biosynthesis protein central cysG - 1.3.1.76,4.99.1.4 ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_7,Sirohm_synth_M CMS1_k127_5650842_17 1173264.KI913949_gene328 8.129e-06 59.0 COG0276@1|root,COG0276@2|Bacteria,1G1UI@1117|Cyanobacteria,1H74W@1150|Oscillatoriales 1117|Cyanobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Chloroa_b-bind,Ferrochelatase CMS1_k127_5650842_16 519989.ECTPHS_02466 6.164e-06 59.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH CMS1_k127_5650842_12 1337093.MBE-LCI_0227 1.216e-25 114.0 COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2U63E@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,Cupin_7,DUF4437 CMS1_k127_5650842_13 1300345.LF41_2955 1.661e-15 91.0 2DEWU@1|root,2ZPJP@2|Bacteria,1P3DY@1224|Proteobacteria,1T86W@1236|Gammaproteobacteria,1XA81@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - CMS1_k127_5650842_6 1379698.RBG1_1C00001G0799 7.079e-91 317.0 2C5G3@1|root,2Z8TT@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5650842_3 530564.Psta_4644 2.482e-134 447.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2IXP2@203682|Planctomycetes 203682|Planctomycetes H Belongs to the precorrin methyltransferase family - - 2.1.1.107,4.2.1.75 ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,TP_methylase CMS1_k127_5650842_11 485916.Dtox_3322 9.086e-26 115.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,HEAT_EZ CMS1_k127_5650842_1 760568.Desku_0199 3.28e-163 528.0 COG2855@1|root,COG2855@2|Bacteria,1UY2J@1239|Firmicutes,25CFK@186801|Clostridia,260TV@186807|Peptococcaceae 186801|Clostridia S PFAM Uncharacterised protein family UPF0324 - - - - - - - - - - - - Cons_hypoth698 CMS1_k127_5650842_0 693661.Arcve_1697 2.237e-215 692.0 COG0247@1|root,arCOG00333@2157|Archaea 2157|Archaea C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K18501 - - - - ko00000 - - - CCG,Fer4_8 CMS1_k127_5650842_8 706587.Desti_0337 2.762e-58 213.0 COG2181@1|root,COG2181@2|Bacteria,1NFYW@1224|Proteobacteria,42VRY@68525|delta/epsilon subdivisions,2WRZ0@28221|Deltaproteobacteria,2MSFY@213462|Syntrophobacterales 28221|Deltaproteobacteria C Nitrate reductase gamma subunit - - - - - - - - - - - - Nitrate_red_gam CMS1_k127_5650842_14 1410634.JHVD01000003_gene1970 2.988e-10 66.0 COG0789@1|root,COG0789@2|Bacteria,2IQJ4@201174|Actinobacteria,4DRJ1@85009|Propionibacteriales 201174|Actinobacteria K helix_turn_helix, mercury resistance hspR GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K13640 - - - - ko00000,ko03000 - - - MerR_1 CMS1_k127_5650842_4 439235.Dalk_1275 3.54e-118 398.0 COG4191@1|root,COG4191@2|Bacteria,1P0U1@1224|Proteobacteria,42PTP@68525|delta/epsilon subdivisions,2WJ8U@28221|Deltaproteobacteria,2MIQ7@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA CMS1_k127_5650842_10 177437.HRM2_07150 5.311e-38 162.0 COG2204@1|root,COG2204@2|Bacteria,1MYSD@1224|Proteobacteria,42SVG@68525|delta/epsilon subdivisions,2WPRW@28221|Deltaproteobacteria,2MK6T@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS1_k127_5650842_2 1265505.ATUG01000001_gene3840 1.272e-138 450.0 COG0730@1|root,COG0730@2|Bacteria,1Q05R@1224|Proteobacteria,42NT9@68525|delta/epsilon subdivisions,2WJVB@28221|Deltaproteobacteria,2MJPE@213118|Desulfobacterales 28221|Deltaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_5650842_5 933262.AXAM01000007_gene2048 2.413e-101 353.0 COG1102@1|root,COG1102@2|Bacteria,1R82J@1224|Proteobacteria,42M5Z@68525|delta/epsilon subdivisions,2WMEJ@28221|Deltaproteobacteria,2MI55@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 CMS1_k127_5650842_7 215803.DB30_0609 1.13e-79 297.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,2YW0B@29|Myxococcales 28221|Deltaproteobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS1_k127_5650842_9 379066.GAU_1219 4.123e-46 169.0 COG0462@1|root,COG0462@2|Bacteria,1ZT7Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N CMS1_k127_5651293_3 234267.Acid_6481 2.036e-18 85.0 COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria 57723|Acidobacteria V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_5651293_4 292564.Cyagr_2552 3.214e-10 61.0 COG1704@1|root,COG1704@2|Bacteria,1G1E8@1117|Cyanobacteria 1117|Cyanobacteria S PFAM LemA family - - - ko:K03744 - - - - ko00000 - - - LemA CMS1_k127_5651293_5 1166018.FAES_3402 2.305e-09 69.0 29XWU@1|root,30JP9@2|Bacteria,4NNWG@976|Bacteroidetes,47PSI@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_5651293_2 1191523.MROS_0059 2.648e-22 106.0 COG1559@1|root,COG1559@2|Bacteria 2|Bacteria F Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG CMS1_k127_5651293_0 316067.Geob_2027 9.956e-59 212.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,42SS9@68525|delta/epsilon subdivisions,2WPND@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM Alpha beta hydrolase fold-3 domain protein - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 CMS1_k127_5657118_0 443144.GM21_0462 2.259e-66 259.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42UA0@68525|delta/epsilon subdivisions,2WS4D@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - CHAT,TPR_12,TPR_7 CMS1_k127_5657118_1 234267.Acid_4400 1.838e-29 134.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - ko:K07004 - - - - ko00000 - - - PKD,PPC,Peptidase_M10,Peptidase_M28,SLH CMS1_k127_5667526_2 1254432.SCE1572_13235 2.641e-100 337.0 COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria,2YU3D@29|Myxococcales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 CMS1_k127_5667526_0 1254432.SCE1572_33570 1.987e-114 379.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2YUI5@29|Myxococcales 28221|Deltaproteobacteria V ABC transporter - - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran,DUF4162 CMS1_k127_5667526_1 869210.Marky_1927 2.461e-103 357.0 COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E COG0076 Glutamate decarboxylase and related PLP-dependent - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC CMS1_k127_5667526_4 1191523.MROS_1634 1.057e-13 85.0 COG0457@1|root,COG0457@2|Bacteria 1191523.MROS_1634|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_5667526_3 234267.Acid_7947 3.51e-63 228.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_5685840_5 1121456.ATVA01000003_gene3026 9.673e-129 439.0 COG1042@1|root,COG1042@2|Bacteria,1NU6B@1224|Proteobacteria,42NAU@68525|delta/epsilon subdivisions,2WJHX@28221|Deltaproteobacteria,2M8HI@213115|Desulfovibrionales 28221|Deltaproteobacteria C ATP-grasp domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig CMS1_k127_5685840_2 861299.J421_4135 1.097e-187 617.0 COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_5685840_9 1408813.AYMG01000001_gene3758 3.667e-05 52.0 2C13E@1|root,33HRI@2|Bacteria,4P5NE@976|Bacteroidetes,1IZ4W@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_5685840_4 585531.HMPREF0063_11711 2.899e-147 480.0 COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4DNDY@85009|Propionibacteriales 201174|Actinobacteria G Glycosyltransferase family 20 otsA GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase CMS1_k127_5685840_8 1472418.BBJC01000001_gene816 5.267e-39 166.0 COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2U9NF@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - Trehalose_PPase CMS1_k127_5685840_1 1089552.KI911559_gene1838 1.604e-232 736.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,2JQKZ@204441|Rhodospirillales 204441|Rhodospirillales G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 CMS1_k127_5685840_7 861299.J421_0303 2.034e-76 265.0 COG3000@1|root,COG3000@2|Bacteria 2|Bacteria I iron ion binding - - - - - - - - - - - - FA_hydroxylase CMS1_k127_5685840_3 448385.sce2299 6.37e-167 544.0 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YWKI@29|Myxococcales 28221|Deltaproteobacteria H Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC CMS1_k127_5685840_0 761193.Runsl_3128 0.0 1378.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,47KCJ@768503|Cytophagia 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ CMS1_k127_5685840_10 305700.B447_00891 0.0005898 51.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV1U@206389|Rhodocyclales 206389|Rhodocyclales T GGDEF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_9,Response_reg CMS1_k127_5685840_6 1341151.ASZU01000006_gene2850 1.639e-104 351.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HB0J@91061|Bacilli,27AUR@186824|Thermoactinomycetaceae 91061|Bacilli I Acyl-CoA dehydrogenase, C-terminal domain fadE - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_5694314_1 861299.J421_6087 1.718e-202 645.0 COG2936@1|root,COG2936@2|Bacteria,1ZTD6@142182|Gemmatimonadetes 142182|Gemmatimonadetes S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 CMS1_k127_5694314_37 1121033.AUCF01000001_gene1917 2.698e-11 74.0 COG0745@1|root,COG0745@2|Bacteria,1N9SP@1224|Proteobacteria,2UFA5@28211|Alphaproteobacteria,2JYZQ@204441|Rhodospirillales 204441|Rhodospirillales KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS1_k127_5694314_34 861299.J421_1295 7.722e-33 135.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_5694314_35 1118235.CAJH01000061_gene3430 8.549e-16 86.0 COG3453@1|root,COG3453@2|Bacteria,1N919@1224|Proteobacteria,1SEMT@1236|Gammaproteobacteria,1X8A2@135614|Xanthomonadales 135614|Xanthomonadales S Putative phosphatase (DUF442) - - - - - - - - - - - - DUF442 CMS1_k127_5694314_39 1423144.Gal_02132 2.242e-06 59.0 COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2UD2M@28211|Alphaproteobacteria,34FHT@302485|Phaeobacter 28211|Alphaproteobacteria S Putative phosphatase (DUF442) blh - - - - - - - - - - - DUF442 CMS1_k127_5694314_0 1408473.JHXO01000013_gene620 1.28e-220 698.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia 976|Bacteroidetes E Glutamate formimidoyltransferase ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N CMS1_k127_5694314_17 1379270.AUXF01000001_gene1966 1.167e-76 275.0 2CESB@1|root,2Z8UZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_5694314_32 316067.Geob_1205 5.704e-39 153.0 COG0824@1|root,COG0824@2|Bacteria,1PF7Z@1224|Proteobacteria,42SV4@68525|delta/epsilon subdivisions,2WPY3@28221|Deltaproteobacteria,43SSY@69541|Desulfuromonadales 28221|Deltaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 CMS1_k127_5694314_40 1550073.JROH01000009_gene1300 1.818e-05 50.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2K2HE@204457|Sphingomonadales 204457|Sphingomonadales L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom CMS1_k127_5694314_16 644966.Tmar_0227 1.601e-78 274.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,3WD1G@538999|Clostridiales incertae sedis 186801|Clostridia CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 ko:K00015,ko:K00090 ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R00717,R01388,R01392,R01739 RC00031,RC00042,RC00084 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C CMS1_k127_5694314_21 861299.J421_3141 1.211e-66 233.0 COG2065@1|root,COG2065@2|Bacteria,1ZTHG@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran CMS1_k127_5694314_4 861299.J421_3142 1.088e-168 535.0 COG0540@1|root,COG0540@2|Bacteria,1ZSN7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS1_k127_5694314_3 861299.J421_3143 2.074e-188 614.0 COG0044@1|root,COG0044@2|Bacteria,1ZT4U@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 CMS1_k127_5694314_36 861299.J421_3144 5.543e-14 85.0 COG1196@1|root,COG1196@2|Bacteria,1ZU4J@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Zinc finger domain - - - - - - - - - - - - - CMS1_k127_5694314_38 379066.GAU_1519 4.917e-10 64.0 COG0268@1|root,COG0268@2|Bacteria,1ZU6B@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p CMS1_k127_5694314_25 379066.GAU_1521 1.655e-62 224.0 COG1354@1|root,COG1354@2|Bacteria,1ZT1G@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA CMS1_k127_5694314_33 867903.ThesuDRAFT_00114 1.873e-37 147.0 COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,24JW7@186801|Clostridia,3WCK5@538999|Clostridiales incertae sedis 186801|Clostridia D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB CMS1_k127_5694314_26 861299.J421_3149 5.888e-61 226.0 COG1187@1|root,COG1187@2|Bacteria,1ZT5B@142182|Gemmatimonadetes 142182|Gemmatimonadetes J S4 RNA-binding domain - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 CMS1_k127_5694314_5 869210.Marky_1233 5.12e-145 477.0 COG1086@1|root,COG1086@2|Bacteria 2|Bacteria GM Polysaccharide biosynthesis protein - - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3,Glycos_transf_4,HTH_45,LicD CMS1_k127_5694314_6 861299.J421_3150 2.059e-143 461.0 COG0714@1|root,COG0714@2|Bacteria,1ZT94@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS1_k127_5694314_18 379066.GAU_1525 1.509e-74 276.0 COG1721@1|root,COG1721@2|Bacteria,1ZSKR@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 CMS1_k127_5694314_13 379066.GAU_1527 1.295e-97 329.0 COG2304@1|root,COG2304@2|Bacteria,1ZSVY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF1194) - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA CMS1_k127_5694314_20 1379270.AUXF01000005_gene782 3.688e-70 258.0 COG2304@1|root,COG2304@2|Bacteria,1ZTCZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S von Willebrand factor type A domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA_2 CMS1_k127_5694314_30 861299.J421_3154 2.148e-44 188.0 COG4783@1|root,COG4783@2|Bacteria,1ZT36@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Oxygen tolerance - - - - - - - - - - - - BatD,SH3_4 CMS1_k127_5694314_12 404589.Anae109_2088 1.181e-109 377.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2YU35@29|Myxococcales 28221|Deltaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C CMS1_k127_5694314_23 861299.J421_3156 1.271e-62 228.0 COG0324@1|root,COG0324@2|Bacteria,1ZTBB@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT CMS1_k127_5694314_8 861299.J421_3157 6.311e-132 430.0 COG0438@1|root,COG0438@2|Bacteria,1ZT2W@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase 4-like - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 CMS1_k127_5694314_29 644966.Tmar_1040 9.776e-51 191.0 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,3WCHZ@538999|Clostridiales incertae sedis 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA CMS1_k127_5694314_27 264732.Moth_0146 2.536e-57 209.0 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,42FD2@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase CMS1_k127_5694314_9 641491.DND132_3227 3.901e-130 435.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2M8S9@213115|Desulfovibrionales 28221|Deltaproteobacteria P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 CMS1_k127_5694314_11 861299.J421_5962 1.361e-116 401.0 COG1473@1|root,COG1473@2|Bacteria,1ZUHE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS1_k127_5694314_7 861299.J421_5963 3.357e-143 467.0 COG4948@1|root,COG4948@2|Bacteria,1ZUQN@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) - - 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N CMS1_k127_5694314_28 861299.J421_6082 5.638e-54 203.0 COG3375@1|root,COG3375@2|Bacteria,1ZUBU@142182|Gemmatimonadetes 142182|Gemmatimonadetes M carboxylic acid catabolic process - - - - - - - - - - - - - CMS1_k127_5694314_24 317025.Tcr_1011 1.508e-62 228.0 COG3391@1|root,COG3391@2|Bacteria,1RGAJ@1224|Proteobacteria,1S2QK@1236|Gammaproteobacteria,462Y7@72273|Thiotrichales 72273|Thiotrichales S amine dehydrogenase activity - - - - - - - - - - - - SGL CMS1_k127_5694314_14 1379270.AUXF01000006_gene228 9.022e-94 311.0 COG0717@1|root,COG0717@2|Bacteria,1ZSN3@142182|Gemmatimonadetes 142182|Gemmatimonadetes F dUTPase dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase CMS1_k127_5694314_31 1232410.KI421424_gene1780 4.907e-43 160.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42UPV@68525|delta/epsilon subdivisions,2WQB6@28221|Deltaproteobacteria,43UXF@69541|Desulfuromonadales 28221|Deltaproteobacteria C NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 CMS1_k127_5694314_15 1379270.AUXF01000006_gene230 1.025e-93 313.0 COG0377@1|root,COG0377@2|Bacteria,1ZT85@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 CMS1_k127_5694314_22 861299.J421_3293 1.227e-62 226.0 COG0852@1|root,COG0852@2|Bacteria,1ZTCJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa CMS1_k127_5694314_2 861299.J421_3292 6.38e-197 632.0 COG0649@1|root,COG0649@2|Bacteria,1ZSV6@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa CMS1_k127_5694314_19 1379270.AUXF01000006_gene233 4.868e-71 251.0 COG1905@1|root,COG1905@2|Bacteria,1ZTJ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx CMS1_k127_5694314_10 1379270.AUXF01000006_gene234 4.041e-126 409.0 COG1894@1|root,COG1894@2|Bacteria,1ZSQD@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB CMS1_k127_5712371_0 521674.Plim_0116 3.071e-179 574.0 COG1760@1|root,COG1760@2|Bacteria,2IXXH@203682|Planctomycetes 203682|Planctomycetes E COG1760 L-serine deaminase - - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta CMS1_k127_5712371_2 96561.Dole_0765 4.032e-52 205.0 2CARY@1|root,32RRX@2|Bacteria,1NGAU@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS1_k127_5712371_1 945713.IALB_2036 9.023e-165 526.0 COG0205@1|root,COG0205@2|Bacteria 2|Bacteria G 6-phosphofructokinase activity pfp GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 ko:K00850,ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK CMS1_k127_5751224_0 357808.RoseRS_3490 1.911e-137 451.0 COG1012@1|root,COG1012@2|Bacteria,2G5NY@200795|Chloroflexi 200795|Chloroflexi C Aldehyde dehydrogenase - - - - - - - - - - - - Aldedh CMS1_k127_5764406_6 557598.LHK_02932 1.997e-73 260.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VIPQ@28216|Betaproteobacteria,2KQ1M@206351|Neisseriales 28216|Betaproteobacteria E Aminotransferase class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_5764406_5 1047013.AQSP01000105_gene1436 9.712e-87 299.0 COG2421@1|root,COG2421@2|Bacteria,2NR72@2323|unclassified Bacteria 2|Bacteria C Acetamidase/Formamidase family - - - - - - - - - - - - FmdA_AmdA CMS1_k127_5764406_8 1082933.MEA186_31066 3.756e-12 71.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria 1224|Proteobacteria P flavoprotein involved in K transport - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 CMS1_k127_5764406_3 1379270.AUXF01000002_gene1577 9.856e-146 489.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_5764406_0 861299.J421_2723 4.502e-229 729.0 COG3258@1|root,COG4993@1|root,COG3258@2|Bacteria,COG4993@2|Bacteria 2|Bacteria G Dehydrogenase - - 1.1.9.1,1.8.2.2 ko:K02030,ko:K17760,ko:K19713 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - Cytochrom_C,Cytochrome_CBB3,PA14,PQQ,PQQ_2,PSCyt3,PSD3,PSD4,PSD5,SBP_bac_3 CMS1_k127_5764406_4 502025.Hoch_4956 4.85e-98 331.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2YU7R@29|Myxococcales 28221|Deltaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C CMS1_k127_5764406_2 861299.J421_1035 2.48e-176 591.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS1_k127_5764406_1 1379270.AUXF01000002_gene1600 1.983e-177 591.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_5764406_7 309807.SRU_0883 4.961e-59 219.0 COG0457@1|root,COG0457@2|Bacteria,4NFMI@976|Bacteroidetes,1FK5M@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 CMS1_k127_5785354_13 448385.sce6976 5.348e-105 368.0 COG1413@1|root,COG3202@1|root,COG1413@2|Bacteria,COG3202@2|Bacteria 2|Bacteria C ATP:ADP antiporter activity - - - ko:K01932,ko:K03301 - - - - ko00000,ko01000 2.A.12 - - Glyco_transf_4,Glycos_transf_1,HEAT_2,TLC CMS1_k127_5785354_20 861299.J421_3913 6.937e-68 241.0 COG1912@1|root,COG1912@2|Bacteria,1ZTIH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans CMS1_k127_5785354_8 861299.J421_3915 1.421e-119 394.0 COG0489@1|root,COG0489@2|Bacteria,1ZSW7@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA CMS1_k127_5785354_14 861299.J421_3916 7.85e-96 330.0 COG0618@1|root,COG0618@2|Bacteria,1ZSS0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DHH family - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 CMS1_k127_5785354_10 1047013.AQSP01000132_gene1724 1.657e-113 383.0 COG1115@1|root,COG1115@2|Bacteria,2NPBF@2323|unclassified Bacteria 2|Bacteria U Sodium:alanine symporter family - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp CMS1_k127_5785354_6 96561.Dole_0417 8.208e-140 481.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WMKZ@28221|Deltaproteobacteria,2MJ0R@213118|Desulfobacterales 28221|Deltaproteobacteria P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N CMS1_k127_5785354_0 861299.J421_3918 3.698e-241 754.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1ZTG9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH CMS1_k127_5785354_45 861299.J421_3920 2.193e-14 78.0 2F9BP@1|root,341NP@2|Bacteria,1ZTX1@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5785354_44 861299.J421_3923 5.969e-15 83.0 2F8UF@1|root,3416F@2|Bacteria,1ZTX9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5785354_26 1232410.KI421420_gene3131 1.509e-55 202.0 COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,42N6T@68525|delta/epsilon subdivisions,2WMMW@28221|Deltaproteobacteria,43VZQ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Binding-protein-dependent transport system inner membrane component - - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 CMS1_k127_5785354_31 1499967.BAYZ01000161_gene394 8.627e-45 176.0 COG3842@1|root,COG3842@2|Bacteria 2|Bacteria P ATPase activity gtsA - 3.6.3.30,3.6.3.55 ko:K02010,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112 ko02010,map02010 M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00491,M00602,M00605,M00606 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1,3.A.1.10,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.2,3.A.1.6.4 - - ABC_tran,TOBE_2 CMS1_k127_5785354_38 278963.ATWD01000002_gene493 3.046e-36 143.0 COG0720@1|root,COG0720@2|Bacteria,3Y4K2@57723|Acidobacteria,2JJD0@204432|Acidobacteriia 204432|Acidobacteriia H PFAM 6-pyruvoyl tetrahydropterin - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS CMS1_k127_5785354_40 1408422.JHYF01000009_gene2173 1.573e-29 130.0 COG1526@1|root,COG1526@2|Bacteria,1TU8R@1239|Firmicutes,24G61@186801|Clostridia,36HJU@31979|Clostridiaceae 186801|Clostridia C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ CMS1_k127_5785354_33 861299.J421_5587 2.114e-40 167.0 COG0746@1|root,COG0746@2|Bacteria,1ZU64@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 CMS1_k127_5785354_43 1499967.BAYZ01000115_gene2924 9.871e-22 106.0 COG1763@1|root,COG1763@2|Bacteria,2NQ5C@2323|unclassified Bacteria 2|Bacteria H Molybdopterin guanine dinucleotide synthesis protein B mobB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.10.1.1,2.7.7.77 ko:K03750,ko:K03753,ko:K13818 ko00790,ko01100,map00790,map01100 - R09735,R11581 RC03462 ko00000,ko00001,ko01000 - - iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805 MoCF_biosynth,MobB,MoeA_C,MoeA_N CMS1_k127_5785354_15 330214.NIDE3341 1.035e-93 333.0 COG0303@1|root,COG0303@2|Bacteria,3J0MX@40117|Nitrospirae 40117|Nitrospirae H Probable molybdopterin binding domain - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N CMS1_k127_5785354_21 1499967.BAYZ01000156_gene556 2.384e-60 216.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.222,2.1.1.64 ko:K00568,ko:K20444 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 CMS1_k127_5785354_1 1379698.RBG1_1C00001G0629 4.108e-204 657.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor etf GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 CMS1_k127_5785354_17 861299.J421_3930 3.718e-83 298.0 COG2025@1|root,COG2025@2|Bacteria,1ZTDU@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Electron transfer flavoprotein domain - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha CMS1_k127_5785354_18 861299.J421_3931 9.534e-83 282.0 COG2086@1|root,COG2086@2|Bacteria,1ZT51@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Electron transfer flavoprotein domain - - - ko:K03521 - - - - ko00000 - - - ETF CMS1_k127_5785354_12 338963.Pcar_2713 8.032e-107 359.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,43SCR@69541|Desulfuromonadales 28221|Deltaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA CMS1_k127_5785354_29 502025.Hoch_6859 5.605e-51 186.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,42SRT@68525|delta/epsilon subdivisions,2WPB8@28221|Deltaproteobacteria,2YV8N@29|Myxococcales 28221|Deltaproteobacteria S EVE domain - - - - - - - - - - - - EVE CMS1_k127_5785354_36 526227.Mesil_1708 1.969e-38 149.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB_2 CMS1_k127_5785354_2 861299.J421_3934 2.814e-194 611.0 COG1960@1|root,COG1960@2|Bacteria,1ZSVE@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS1_k127_5785354_23 861299.J421_3936 9.221e-60 221.0 COG1409@1|root,COG1409@2|Bacteria,1ZTQ6@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos CMS1_k127_5785354_5 426117.M446_0777 1.821e-140 466.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,1JXTM@119045|Methylobacteriaceae 28211|Alphaproteobacteria C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS1_k127_5785354_30 1379698.RBG1_1C00001G0904 9.601e-46 175.0 COG1024@1|root,COG1024@2|Bacteria 2|Bacteria I Enoyl-CoA hydratase bamR - 4.2.1.100 ko:K07537 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05597 RC03168 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_5785354_24 1379698.RBG1_1C00001G0906 5.215e-57 210.0 COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_5785354_19 861299.J421_3940 1.286e-73 262.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1,Sugar_tr CMS1_k127_5785354_28 457570.Nther_2188 4.919e-54 215.0 COG4805@1|root,COG4805@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 CMS1_k127_5785354_27 1051632.TPY_0086 6.342e-55 197.0 COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,24KJU@186801|Clostridia 186801|Clostridia M acetyltransferase (GNAT) family - - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Acetyltransf_4 CMS1_k127_5785354_34 1089455.MOPEL_009_00300 2.577e-40 165.0 COG0053@1|root,COG0053@2|Bacteria,2GQJJ@201174|Actinobacteria 201174|Actinobacteria P Pfam Cation efflux - - - - - - - - - - - - Cation_efflux CMS1_k127_5785354_48 455436.DS989816_gene2061 5.489e-13 80.0 COG2105@1|root,COG2105@2|Bacteria,1N814@1224|Proteobacteria,1SB38@1236|Gammaproteobacteria,46C2B@72275|Alteromonadaceae 1236|Gammaproteobacteria S Gamma-glutamyl cyclotransferase, AIG2-like - - - - - - - - - - - - GGACT CMS1_k127_5785354_49 867903.ThesuDRAFT_01802 7.95e-10 71.0 COG3118@1|root,COG3118@2|Bacteria,1VEPC@1239|Firmicutes,24UN5@186801|Clostridia 186801|Clostridia O TIGRFAM bacillithiol system protein YtxJ - - - - - - - - - - - - DUF2847 CMS1_k127_5785354_9 861299.J421_3942 1.059e-113 375.0 COG1208@1|root,COG1208@2|Bacteria,1ZSYR@142182|Gemmatimonadetes 142182|Gemmatimonadetes JM Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase CMS1_k127_5785354_35 1278073.MYSTI_04470 1.022e-39 158.0 COG0662@1|root,COG0662@2|Bacteria,1NADF@1224|Proteobacteria,4383M@68525|delta/epsilon subdivisions,2X9WE@28221|Deltaproteobacteria,2YVKF@29|Myxococcales 28221|Deltaproteobacteria G Mannose-6-phosphate isomerase - - - - - - - - - - - - Cupin_2 CMS1_k127_5785354_39 247490.KSU1_B0018 1.896e-31 138.0 COG0437@1|root,COG0437@2|Bacteria,2J376@203682|Planctomycetes 203682|Planctomycetes C 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - CMS1_k127_5785354_32 379066.GAU_0727 9.147e-41 162.0 COG1512@1|root,COG1512@2|Bacteria,1ZT1H@142182|Gemmatimonadetes 142182|Gemmatimonadetes S TPM domain - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase CMS1_k127_5785354_41 379066.GAU_0728 8.836e-29 129.0 COG1708@1|root,COG1708@2|Bacteria,1ZTN5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S nucleotidyltransferase activity - - - - - - - - - - - - - CMS1_k127_5785354_25 1379270.AUXF01000004_gene3149 9.394e-56 200.0 COG1704@1|root,COG1704@2|Bacteria,1ZTQE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA CMS1_k127_5785354_16 869210.Marky_0691 8.288e-88 299.0 COG2084@1|root,COG2084@2|Bacteria,1WIBK@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I PFAM NAD binding domain of 6-phosphogluconate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 CMS1_k127_5785354_37 861299.J421_3944 4.977e-38 151.0 COG0712@1|root,COG0712@2|Bacteria,1ZTP8@142182|Gemmatimonadetes 142182|Gemmatimonadetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP CMS1_k127_5785354_42 880073.Calab_0235 5.22e-24 108.0 COG0711@1|root,COG0711@2|Bacteria,2NPWH@2323|unclassified Bacteria 2|Bacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B CMS1_k127_5785354_46 1236514.BAKL01000034_gene2864 1.075e-13 74.0 COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,2FTSZ@200643|Bacteroidia,4ARQC@815|Bacteroidaceae 976|Bacteroidetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C CMS1_k127_5785354_22 861299.J421_3947 3.663e-60 224.0 COG0356@1|root,COG0356@2|Bacteria,1ZSQ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A CMS1_k127_5785354_7 861299.J421_3951 2.808e-130 426.0 COG0714@1|root,COG0714@2|Bacteria,1ZT5U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS1_k127_5785354_47 1379270.AUXF01000004_gene3255 2.495e-13 85.0 COG0457@1|root,COG0457@2|Bacteria 1379270.AUXF01000004_gene3255|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_5785354_11 518766.Rmar_1440 2.426e-109 366.0 COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP CMS1_k127_5785354_3 518766.Rmar_1441 4.972e-167 535.0 COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes 976|Bacteroidetes V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5785354_4 518766.Rmar_1442 3.755e-166 531.0 COG0577@1|root,COG0577@2|Bacteria,4NECN@976|Bacteroidetes,1FIY8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS1_k127_5794363_0 861299.J421_1230 3.419e-93 338.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_5878788_4 379066.GAU_0591 4.4e-51 189.0 COG4206@1|root,COG4206@2|Bacteria,1ZUAE@142182|Gemmatimonadetes 142182|Gemmatimonadetes H TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug CMS1_k127_5878788_1 1121106.JQKB01000010_gene431 1.073e-128 438.0 COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,2JR8N@204441|Rhodospirillales 204441|Rhodospirillales E Putative serine dehydratase domain - - - - - - - - - - - - Ala_racemase_N,D-ser_dehydrat CMS1_k127_5878788_3 404589.Anae109_3542 2.094e-54 200.0 2DN8B@1|root,32W2U@2|Bacteria,1R03I@1224|Proteobacteria,42XCH@68525|delta/epsilon subdivisions,2WT8A@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_5878788_5 177439.DP2251 3.609e-46 181.0 COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,42T7R@68525|delta/epsilon subdivisions,2WPDU@28221|Deltaproteobacteria,2MK9K@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0066 - - - - - - - - - - - - UPF0066 CMS1_k127_5878788_2 258594.RPA0395 1.002e-64 235.0 COG1896@1|root,COG1896@2|Bacteria,1MXEZ@1224|Proteobacteria,2U0WW@28211|Alphaproteobacteria,3JZ3I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S HD domain - - - ko:K07023 - - - - ko00000 - - - HD_3 CMS1_k127_5878788_6 929556.Solca_3837 5.095e-24 112.0 2C312@1|root,2Z7N1@2|Bacteria,4NFNW@976|Bacteroidetes,1IYX2@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_5878788_0 861299.J421_2042 7.935e-208 661.0 COG0308@1|root,COG0308@2|Bacteria,1ZU50@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 CMS1_k127_5886586_0 861299.J421_1230 7.376e-107 382.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_5886586_1 1202768.JROF01000006_gene2515 1.503e-08 62.0 COG0596@1|root,arCOG01648@2157|Archaea,2XUGU@28890|Euryarchaeota,23TFI@183963|Halobacteria 183963|Halobacteria E hydrolases or acyltransferases (alpha beta hydrolase superfamily) pca - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6 CMS1_k127_5891346_1 1191523.MROS_1660 1.772e-168 538.0 COG4992@1|root,COG4992@2|Bacteria 2|Bacteria E N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity rocD GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iYO844.BSU40340 Aminotran_3 CMS1_k127_5891346_0 479434.Sthe_3117 0.0 1049.0 COG4447@1|root,COG4447@2|Bacteria,2G678@200795|Chloroflexi 200795|Chloroflexi S PFAM glycosyl hydrolase BNR repeat-containing protein - - - - - - - - - - - - Sortilin-Vps10 CMS1_k127_5891896_2 1379270.AUXF01000006_gene180 7.322e-232 726.0 COG1884@1|root,COG1884@2|Bacteria,1ZUKS@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Methylmalonyl-CoA mutase - - 5.4.99.13,5.4.99.2 ko:K01848,ko:K11942 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase CMS1_k127_5891896_19 1379270.AUXF01000006_gene179 3.409e-107 361.0 COG1703@1|root,COG1703@2|Bacteria,1ZT8J@142182|Gemmatimonadetes 142182|Gemmatimonadetes E ArgK protein - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK CMS1_k127_5891896_22 468059.AUHA01000003_gene1806 1.027e-92 340.0 COG2239@1|root,COG2239@2|Bacteria,4NGGN@976|Bacteroidetes,1IPNC@117747|Sphingobacteriia 976|Bacteroidetes P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N CMS1_k127_5891896_44 264732.Moth_0597 6.556e-40 156.0 COG2928@1|root,COG2928@2|Bacteria,1V6FM@1239|Firmicutes,24JQ1@186801|Clostridia,42GJH@68295|Thermoanaerobacterales 186801|Clostridia S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 CMS1_k127_5891896_43 469371.Tbis_0669 2.201e-41 167.0 COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4E0JB@85010|Pseudonocardiales 201174|Actinobacteria S Transporter associated domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 CMS1_k127_5891896_26 861299.J421_3352 1.729e-83 297.0 COG1253@1|root,COG1253@2|Bacteria,1ZT3E@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC CMS1_k127_5891896_50 1379270.AUXF01000006_gene176 3.072e-27 117.0 COG0319@1|root,COG0319@2|Bacteria,1ZTUP@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 CMS1_k127_5891896_9 861299.J421_3354 5.993e-159 531.0 COG1480@1|root,COG1480@2|Bacteria 2|Bacteria O 7TM receptor with intracellular HD hydrolase yqfF - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD CMS1_k127_5891896_15 379066.GAU_1714 1.361e-116 401.0 COG1702@1|root,COG1702@2|Bacteria,1ZSSD@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PhoH-like protein - - - ko:K06217 - - - - ko00000 - - - PhoH CMS1_k127_5891896_10 1121920.AUAU01000016_gene1359 1.671e-156 514.0 COG0173@1|root,COG0173@2|Bacteria,3Y3SP@57723|Acidobacteria 57723|Acidobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon CMS1_k127_5891896_51 1121918.ARWE01000001_gene1885 2.149e-23 105.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria,43SM8@69541|Desulfuromonadales 28221|Deltaproteobacteria G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 CMS1_k127_5891896_60 379066.GAU_1716 4.728e-06 58.0 2F92S@1|root,341ED@2|Bacteria,1ZU0W@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_5891896_17 861299.J421_3358 1.154e-111 378.0 COG0820@1|root,COG0820@2|Bacteria,1ZTAJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM CMS1_k127_5891896_57 861299.J421_3359 4.123e-09 67.0 2E48Y@1|root,32Z4R@2|Bacteria,1ZV5W@142182|Gemmatimonadetes 142182|Gemmatimonadetes S LytR cell envelope-related transcriptional attenuator - - - - - - - - - - - - LytR_C CMS1_k127_5891896_41 1379270.AUXF01000006_gene171 9.891e-44 166.0 COG1713@1|root,COG1713@2|Bacteria,1ZTTH@142182|Gemmatimonadetes 142182|Gemmatimonadetes H HD superfamily hydrolase involved in NAD metabolism - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - - CMS1_k127_5891896_27 1121468.AUBR01000008_gene2061 2.214e-80 288.0 COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,42F66@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase CMS1_k127_5891896_24 653733.Selin_2222 1.598e-88 303.0 COG0413@1|root,COG0413@2|Bacteria 2|Bacteria H 3-methyl-2-oxobutanoate hydroxymethyltransferase activity panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf CMS1_k127_5891896_45 861299.J421_3360 2.036e-38 153.0 COG0801@1|root,COG1713@1|root,COG0801@2|Bacteria,COG1713@2|Bacteria,1ZTTH@142182|Gemmatimonadetes 142182|Gemmatimonadetes H HD superfamily hydrolase involved in NAD metabolism - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - - CMS1_k127_5891896_53 861299.J421_3361 2.359e-20 104.0 COG1539@1|root,COG1539@2|Bacteria 2|Bacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB2 - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB CMS1_k127_5891896_34 1128421.JAGA01000002_gene1341 5.532e-63 226.0 COG0159@1|root,COG0159@2|Bacteria,2NP9W@2323|unclassified Bacteria 2|Bacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA CMS1_k127_5891896_12 379066.GAU_1721 2.363e-147 488.0 COG2206@1|root,COG2206@2|Bacteria,1ZUTT@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD CMS1_k127_5891896_21 379066.GAU_1722 2.902e-95 340.0 COG1413@1|root,COG1413@2|Bacteria,1ZUI4@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS1_k127_5891896_6 861299.J421_3363 1.221e-169 552.0 COG0133@1|root,COG0133@2|Bacteria,1ZSUM@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_5891896_37 861299.J421_3365 2.974e-58 213.0 COG0134@1|root,COG0134@2|Bacteria,1ZTMA@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Indole-3-glycerol phosphate synthase - - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS CMS1_k127_5891896_31 379066.GAU_1726 3.171e-76 272.0 COG1974@1|root,COG1974@2|Bacteria,1ZSSM@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 CMS1_k127_5891896_23 861299.J421_3367 6.1e-92 314.0 COG0547@1|root,COG0547@2|Bacteria,1ZTDS@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 CMS1_k127_5891896_32 1379270.AUXF01000006_gene161 2.922e-67 237.0 COG0101@1|root,COG0101@2|Bacteria,1ZSRZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 CMS1_k127_5891896_28 237368.SCABRO_03773 3.027e-77 276.0 COG0176@1|root,COG0176@2|Bacteria,2J0IB@203682|Planctomycetes 203682|Planctomycetes H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway - - - - - - - - - - - - TAL_FSA CMS1_k127_5891896_18 379066.GAU_1730 1.289e-110 385.0 COG0265@1|root,COG0265@2|Bacteria,1ZTAM@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS1_k127_5891896_11 575540.Isop_0660 7.211e-152 506.0 COG0015@1|root,COG0015@2|Bacteria,2IXU4@203682|Planctomycetes 203682|Planctomycetes F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 CMS1_k127_5891896_13 258594.RPA0558 2.087e-121 404.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TS0T@28211|Alphaproteobacteria,3JRJ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F phosphoribosylaminoimidazole-succinocarboxamide synthase purC2 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt CMS1_k127_5891896_35 861299.J421_3375 4.263e-60 224.0 COG0688@1|root,COG0688@2|Bacteria,1ZU9Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase CMS1_k127_5891896_36 379066.GAU_1734 1.722e-59 227.0 COG1183@1|root,COG1183@2|Bacteria,1ZTJP@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf CMS1_k127_5891896_56 861299.J421_3377 2.168e-15 88.0 COG1828@1|root,COG1828@2|Bacteria,1ZU3W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - PurS CMS1_k127_5891896_30 656024.FsymDg_0148 2.344e-76 268.0 COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4ERSR@85013|Frankiales 201174|Actinobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 CMS1_k127_5891896_54 1144275.COCOR_01361 3.013e-19 91.0 COG3809@1|root,COG3809@2|Bacteria,1Q8Z4@1224|Proteobacteria,42UTF@68525|delta/epsilon subdivisions,2WXCZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Transcription factor zinc-finger - - - ko:K09981 - - - - ko00000 - - - zf-TFIIB CMS1_k127_5891896_1 861299.J421_3380 5.217e-291 913.0 COG0046@1|root,COG0046@2|Bacteria,1ZT8W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS1_k127_5891896_7 861299.J421_3381 1.223e-168 542.0 COG0034@1|root,COG0034@2|Bacteria,1ZTD7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6 CMS1_k127_5891896_0 639282.DEFDS_0235 0.0 1066.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GF76@200930|Deferribacteres 200930|Deferribacteres G PEP-utilising enzyme, mobile domain - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N CMS1_k127_5891896_20 1142394.PSMK_05030 4.989e-101 368.0 COG0388@1|root,COG0388@2|Bacteria,2IXDC@203682|Planctomycetes 203682|Planctomycetes K COG0454 Histone acetyltransferase HPA2 and related - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase CMS1_k127_5891896_39 1051501.AYTL01000027_gene466 7.313e-47 188.0 COG0388@1|root,COG3153@1|root,COG0388@2|Bacteria,COG3153@2|Bacteria,1TQAZ@1239|Firmicutes,4HCQW@91061|Bacilli,1ZB16@1386|Bacillus 91061|Bacilli K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase yhcX - - - - - - - - - - - Acetyltransf_1,CN_hydrolase CMS1_k127_5891896_48 1142394.PSMK_17170 2.443e-29 127.0 COG1051@1|root,COG1051@2|Bacteria 2|Bacteria F GDP-mannose mannosyl hydrolase activity - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX CMS1_k127_5891896_29 861299.J421_1841 3.493e-77 267.0 COG2324@1|root,COG2324@2|Bacteria,1ZU2K@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carotenoid biosynthesis protein - - - - - - - - - - - - Caroten_synth CMS1_k127_5891896_52 309803.CTN_1118 3.971e-21 109.0 COG0142@1|root,COG0142@2|Bacteria 2|Bacteria H isoprenoid biosynthetic process hepT - 2.5.1.30,2.5.1.90 ko:K00805,ko:K02523 ko00900,ko01110,map00900,map01110 - R09247,R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt CMS1_k127_5891896_33 861299.J421_1840 1.538e-65 251.0 COG1562@1|root,COG1562@2|Bacteria,1ZU4S@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Squalene/phytoene synthase - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY CMS1_k127_5891896_5 644282.Deba_1975 4.067e-170 548.0 COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM DNA photolyase, FAD-binding phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 CMS1_k127_5891896_40 883.DvMF_1041 1.507e-44 171.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42MBJ@68525|delta/epsilon subdivisions,2WNWX@28221|Deltaproteobacteria,2MBDA@213115|Desulfovibrionales 28221|Deltaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly CMS1_k127_5891896_3 330214.NIDE2036 9.76e-196 631.0 COG0272@1|root,COG0272@2|Bacteria,3J0W8@40117|Nitrospirae 40117|Nitrospirae L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 CMS1_k127_5891896_8 765912.Thimo_1388 1.318e-164 544.0 COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,1TK7U@1236|Gammaproteobacteria,1X089@135613|Chromatiales 135613|Chromatiales L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8 CMS1_k127_5891896_4 391625.PPSIR1_32944 7.597e-176 592.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,43BX1@68525|delta/epsilon subdivisions,2X77U@28221|Deltaproteobacteria,2YTZ8@29|Myxococcales 28221|Deltaproteobacteria Q Phytoene dehydrogenase - - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase CMS1_k127_5891896_61 1278073.MYSTI_05205 0.0004443 53.0 COG4206@1|root,COG4206@2|Bacteria,1QXUW@1224|Proteobacteria,43C7J@68525|delta/epsilon subdivisions,2X7HV@28221|Deltaproteobacteria,2YU5W@29|Myxococcales 28221|Deltaproteobacteria H CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS1_k127_5891896_55 1545915.JROG01000009_gene2862 4.615e-19 96.0 COG1695@1|root,COG1695@2|Bacteria,1PCI9@1224|Proteobacteria,2V1YM@28211|Alphaproteobacteria,2KC7X@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS1_k127_5891896_49 1292034.OR37_03559 1.35e-28 128.0 COG0412@1|root,COG0412@2|Bacteria 2|Bacteria Q carboxymethylenebutenolidase activity - - 3.1.1.45 ko:K01061,ko:K06889 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - Asp_protease_2,Chlorophyllase2,DLH CMS1_k127_5891896_42 861299.J421_4103 1.271e-41 176.0 COG0515@1|root,COG5184@1|root,COG0515@2|Bacteria,COG5184@2|Bacteria,1ZUHN@142182|Gemmatimonadetes 142182|Gemmatimonadetes DKLTZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - Pkinase,RCC1 CMS1_k127_5891896_38 443143.GM18_3929 2.818e-56 226.0 COG0457@1|root,COG4946@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4946@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42UA0@68525|delta/epsilon subdivisions,2WS4D@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - CHAT,TPR_12,TPR_7 CMS1_k127_5891896_59 317619.ANKN01000029_gene944 3.951e-06 57.0 COG0457@1|root,COG0457@2|Bacteria,1G5S0@1117|Cyanobacteria 1117|Cyanobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_12 CMS1_k127_5891896_46 626887.J057_19220 2.249e-36 146.0 COG2199@1|root,COG3706@2|Bacteria,1MX83@1224|Proteobacteria,1RMRP@1236|Gammaproteobacteria,467NS@72275|Alteromonadaceae 1236|Gammaproteobacteria T Cache domain - - - - - - - - - - - - GGDEF,PAS_3,PAS_4,PAS_9,dCache_1 CMS1_k127_5891896_14 861299.J421_5836 5.495e-117 406.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_5891896_16 1128421.JAGA01000003_gene3264 4.474e-114 394.0 COG1404@1|root,COG1404@2|Bacteria,2NQU8@2323|unclassified Bacteria 2|Bacteria O Subtilase family - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Inhibitor_I9,Peptidase_S8 CMS1_k127_5891896_58 926566.Terro_2938 3.047e-06 55.0 COG0823@1|root,COG3391@1|root,COG0823@2|Bacteria,COG3391@2|Bacteria,3Y31A@57723|Acidobacteria,2JHIN@204432|Acidobacteriia 57723|Acidobacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - - CMS1_k127_5891896_25 134676.ACPL_4862 3.068e-86 306.0 COG1404@1|root,COG4733@1|root,COG5184@1|root,COG1404@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,2IG31@201174|Actinobacteria,4DEHQ@85008|Micromonosporales 201174|Actinobacteria DZ PFAM regulator of chromosome condensation, RCC1 - - - - - - - - - - - - Big_3_5,Flg_new,Pkinase,RCC1 CMS1_k127_5921371_7 861299.J421_4052 3.019e-39 155.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_4052|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_5921371_11 1121920.AUAU01000008_gene1592 1.016e-23 106.0 COG1959@1|root,COG1959@2|Bacteria,3Y8ZE@57723|Acidobacteria 57723|Acidobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 CMS1_k127_5921371_9 945713.IALB_0862 1.893e-26 123.0 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Alginate_exp,BBP2,MucBP,Porin_4,SLH CMS1_k127_5921371_12 1123278.KB893387_gene4385 5.434e-14 82.0 COG0723@1|root,COG0723@2|Bacteria,4PNQJ@976|Bacteroidetes,47SP8@768503|Cytophagia 976|Bacteroidetes C Rieske [2Fe-2S] domain - - - ko:K03886 ko00190,ko01100,map00190,map01100 M00151 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske CMS1_k127_5921371_2 880073.Calab_3613 7.484e-86 296.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944 - ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_B_N_2,Cytochrome_B CMS1_k127_5921371_1 290397.Adeh_1764 1.241e-223 705.0 COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto CMS1_k127_5921371_0 398767.Glov_1056 1.056e-286 902.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2WKKT@28221|Deltaproteobacteria,43VZF@69541|Desulfuromonadales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA NapA NarB subfamily - - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal CMS1_k127_5921371_10 1443665.JACA01000001_gene2623 5.599e-24 116.0 COG3043@1|root,COG3043@2|Bacteria,4NG82@976|Bacteroidetes,1HZDY@117743|Flavobacteriia,2YHZ9@290174|Aquimarina 976|Bacteroidetes C Nitrate reductase cytochrome c-type subunit (NapB) - - - ko:K02568 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798 RC02812 ko00000,ko00001,ko00002 - - - Cytochrome_C554,NapB CMS1_k127_5921371_8 694427.Palpr_2096 2.782e-29 124.0 COG3945@1|root,COG3945@2|Bacteria 2|Bacteria P hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin CMS1_k127_5921371_6 1214101.BN159_4302 9.323e-45 174.0 COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase type 11 - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 CMS1_k127_5921371_13 1385511.N783_18020 7.081e-09 66.0 COG1525@1|root,COG1525@2|Bacteria,1V3MZ@1239|Firmicutes,4HHPS@91061|Bacilli,2YA8M@289201|Pontibacillus 91061|Bacilli L Staphylococcal nuclease homologues - - - - - - - - - - - - Excalibur,SNase CMS1_k127_5921371_3 479434.Sthe_2120 1.267e-79 281.0 COG0309@1|root,COG0309@2|Bacteria,2G7TM@200795|Chloroflexi,27XK5@189775|Thermomicrobia 189775|Thermomicrobia O AIR synthase related protein, C-terminal domain - - - - - - - - - - - - AIRS,AIRS_C CMS1_k127_5921371_4 1449069.JMLO01000011_gene2484 8.66e-65 231.0 COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4FV36@85025|Nocardiaceae 201174|Actinobacteria S glyoxalase bleomycin resistance protein dioxygenase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K06996 - - - - ko00000 - - - Glyoxalase CMS1_k127_5921371_5 1183438.GKIL_2152 1.892e-52 191.0 COG1228@1|root,COG1228@2|Bacteria 2|Bacteria Q imidazolonepropionase activity - - - - - - - - - - - - Amidohydro_1 CMS1_k127_5941598_5 1340493.JNIF01000004_gene1025 1.24e-47 198.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - ko:K07004 - - - - ko00000 - - - PKD,PPC,Peptidase_M10,Peptidase_M28,SLH CMS1_k127_5941598_3 649349.Lbys_1863 5.702e-69 263.0 COG1680@1|root,COG1680@2|Bacteria,4NER1@976|Bacteroidetes 976|Bacteroidetes V Beta-lactamase class C and other penicillin binding - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase CMS1_k127_5941598_2 867903.ThesuDRAFT_00094 5.943e-83 289.0 COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,24ETR@186801|Clostridia 186801|Clostridia C Belongs to the Glu Leu Phe Val dehydrogenases family ldh - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_5941598_1 861299.J421_1024 1.36e-133 447.0 COG2132@1|root,COG2132@2|Bacteria,1ZUD9@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Multicopper oxidase - - 1.16.3.3 ko:K22348 - - - - ko00000,ko01000 - - - Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_5941598_6 382464.ABSI01000011_gene2976 1.588e-46 170.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 CMS1_k127_5941598_7 861299.J421_0226 3.855e-36 158.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_0226|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_5941598_0 861299.J421_5846 2.324e-171 563.0 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS1_k127_5941598_4 1379270.AUXF01000002_gene1587 1.237e-61 216.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1587|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_5997242_2 861299.J421_2641 1.719e-46 184.0 COG1519@1|root,COG1519@2|Bacteria,1ZSXB@142182|Gemmatimonadetes 142182|Gemmatimonadetes M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N CMS1_k127_5997242_1 861299.J421_4004 1.598e-54 200.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS1_k127_5997242_3 1379270.AUXF01000005_gene334 2.718e-23 113.0 COG1629@1|root,COG1629@2|Bacteria 2|Bacteria P transport - - - - - - - - - - - - CarboxypepD_reg,Plug CMS1_k127_5997242_0 379066.GAU_0720 2.725e-89 307.0 COG4206@1|root,COG4206@2|Bacteria,1ZUC2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug CMS1_k127_6029918_0 1379270.AUXF01000007_gene968 3.009e-95 328.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene968|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_6029918_1 234267.Acid_4902 4.244e-58 210.0 COG5549@1|root,COG5549@2|Bacteria,3Y2IY@57723|Acidobacteria 57723|Acidobacteria O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 CMS1_k127_609549_2 1379270.AUXF01000007_gene994 3.492e-57 204.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_609549_1 292459.STH3178 2.059e-144 466.0 COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia 186801|Clostridia E Aminotransferase - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 CMS1_k127_609549_3 867845.KI911784_gene1748 3.238e-40 155.0 COG2967@1|root,COG2967@2|Bacteria 2|Bacteria P mitochondrion morphogenesis apaG - - ko:K06195 - - - - ko00000 - - - DUF525 CMS1_k127_609549_4 1379270.AUXF01000002_gene1705 1.459e-30 140.0 28NRS@1|root,2ZBQZ@2|Bacteria,1ZV13@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_609549_0 502025.Hoch_6444 5.109e-268 848.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2WWD4@28221|Deltaproteobacteria,2YTYG@29|Myxococcales 28221|Deltaproteobacteria S oligopeptide transporter, OPT family - - - - - - - - - - - - OPT CMS1_k127_609549_5 880072.Desac_1649 2.697e-24 109.0 COG0613@1|root,COG0613@2|Bacteria,1NHBC@1224|Proteobacteria,4312E@68525|delta/epsilon subdivisions,2WWDH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PHP-associated - - - - - - - - - - - - PHP,PHP_C CMS1_k127_61433_3 880073.Calab_2456 6.455e-15 79.0 COG0789@1|root,COG0789@2|Bacteria,2NPTR@2323|unclassified Bacteria 2|Bacteria K Transcriptional regulator, MerR family - - 2.1.1.37 ko:K00558,ko:K13639,ko:K13640 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03000,ko03032,ko03036 - - - DNA_methylase,MerR,MerR_1 CMS1_k127_61433_2 215803.DB30_0609 4.714e-86 294.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,2YW0B@29|Myxococcales 28221|Deltaproteobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS1_k127_61433_1 379066.GAU_1219 3.95e-145 465.0 COG0462@1|root,COG0462@2|Bacteria,1ZT7Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N CMS1_k127_61433_0 1125863.JAFN01000001_gene2769 5.486e-183 588.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria 28221|Deltaproteobacteria C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase CMS1_k127_614574_0 1379270.AUXF01000002_gene1345 7.217e-264 843.0 COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_6210172_15 880073.Calab_1599 3.684e-117 392.0 COG2864@1|root,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria 2|Bacteria C Cytochrome b subunit of formate dehydrogenase-like protein - - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS1_k127_6210172_17 439235.Dalk_1856 2.647e-107 373.0 COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD fdnI - - - - - - - - - - iAF987.Gmet_1061 NrfD CMS1_k127_6210172_26 439235.Dalk_1855 2.69e-69 248.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NS2@68525|delta/epsilon subdivisions,2WMA0@28221|Deltaproteobacteria,2MN9Z@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain fdnH - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4_11,Fer4_4,NrfD CMS1_k127_6210172_1 1379698.RBG1_1C00001G0777 2.886e-318 1001.0 COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria 2|Bacteria P Prokaryotic cytochrome b561 cbcY - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese CMS1_k127_6210172_41 1192034.CAP_0163 2.782e-24 120.0 COG3303@1|root,COG3303@2|Bacteria,1MYBV@1224|Proteobacteria,42SER@68525|delta/epsilon subdivisions,2WPC2@28221|Deltaproteobacteria,2YUR5@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 CMS1_k127_6210172_34 1379698.RBG1_1C00001G0858 4.73e-47 185.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C CMS1_k127_6210172_21 671143.DAMO_0822 5.047e-99 354.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS1_k127_6210172_31 671143.DAMO_0820 1.041e-49 182.0 COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria 2|Bacteria C Rieske [2Fe-2S] domain petA - 1.10.2.2,1.10.9.1 ko:K00411,ko:K02636,ko:K03886 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - iAF987.Gmet_1922 CytB6-F_Fe-S,Rieske,UCR_Fe-S_N CMS1_k127_6210172_14 1379698.RBG1_1C00001G0780 1.094e-143 464.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B CMS1_k127_6210172_6 926550.CLDAP_30940 7.294e-205 654.0 COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi 200795|Chloroflexi E Pyridoxal-dependent decarboxylase conserved domain - - 4.1.1.105,4.1.1.28,4.1.2.27 ko:K01593,ko:K01634 ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034 M00037,M00042,M00100 R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516 RC00264,RC00299,RC00721,RC01266 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC CMS1_k127_6210172_23 1379270.AUXF01000003_gene3566 1.486e-82 287.0 COG0846@1|root,COG0846@2|Bacteria,1ZTRK@142182|Gemmatimonadetes 142182|Gemmatimonadetes K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 CMS1_k127_6210172_36 1255043.TVNIR_1704 1.966e-36 140.0 COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,1S809@1236|Gammaproteobacteria,1WZQ6@135613|Chromatiales 135613|Chromatiales P DsrE/DsrF-like family - - - ko:K06039 - - - - ko00000 - - - DrsE CMS1_k127_6210172_33 861299.J421_2741 1.235e-49 180.0 COG2332@1|root,COG2332@2|Bacteria,1ZTNV@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH - - - ko:K02197 - - - - ko00000 - - - CcmE CMS1_k127_6210172_4 861299.J421_2742 1.057e-251 796.0 COG1138@1|root,COG1138@2|Bacteria,1ZTBY@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome c-type biogenesis protein CcmF C-terminal - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm CMS1_k127_6210172_40 861299.J421_2743 1.024e-24 121.0 COG3088@1|root,COG3088@2|Bacteria,1ZTS7@142182|Gemmatimonadetes 142182|Gemmatimonadetes P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH CMS1_k127_6210172_42 1379270.AUXF01000004_gene3073 3.58e-16 90.0 29W2Z@1|root,30HMM@2|Bacteria,1ZTXQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_6210172_11 1379270.AUXF01000004_gene3069 2.236e-154 516.0 28M0D@1|root,2ZAFE@2|Bacteria,1ZUP5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative ATP-binding cassette - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran_2 CMS1_k127_6210172_20 1379270.AUXF01000004_gene3068 1.497e-101 360.0 COG1131@1|root,COG1131@2|Bacteria,1ZUPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_6210172_29 177437.HRM2_33700 4.632e-51 202.0 COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,42R14@68525|delta/epsilon subdivisions,2WN3R@28221|Deltaproteobacteria,2MJNR@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM transglutaminase domain protein - - - - - - - - - - - - Transglut_core CMS1_k127_6210172_47 891968.Anamo_1817 7.273e-07 59.0 COG2110@1|root,COG2110@2|Bacteria,3TB5Z@508458|Synergistetes 508458|Synergistetes S C-terminal domain of histone - - - - - - - - - - - - Macro CMS1_k127_6210172_43 1267534.KB906755_gene4099 5.602e-12 77.0 COG0457@1|root,COG0457@2|Bacteria,3Y4E6@57723|Acidobacteria,2JM2V@204432|Acidobacteriia 204432|Acidobacteriia S TPR repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 CMS1_k127_6210172_38 404589.Anae109_1180 1.09e-26 113.0 COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,42VE1@68525|delta/epsilon subdivisions,2WR7D@28221|Deltaproteobacteria,2Z0IS@29|Myxococcales 28221|Deltaproteobacteria P CutA1 divalent ion tolerance protein cutA - - ko:K03926 - - - - ko00000 - - - CutA1 CMS1_k127_6210172_0 562970.Btus_2178 0.0 1167.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,2781C@186823|Alicyclobacillaceae 91061|Bacilli L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran CMS1_k127_6210172_24 1379270.AUXF01000004_gene3061 1.81e-73 257.0 COG1842@1|root,COG1842@2|Bacteria,1ZT82@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT PspA/IM30 family - - - ko:K03969 - - - - ko00000 - - - PspA_IM30 CMS1_k127_6210172_46 709986.Deima_0886 1.995e-09 70.0 COG3842@1|root,COG3842@2|Bacteria,1WJFQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E ABC-type spermidine putrescine transport systems, ATPase components - - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 CMS1_k127_6210172_27 671143.DAMO_2882 2.154e-64 231.0 COG0668@1|root,COG0668@2|Bacteria,2NPY4@2323|unclassified Bacteria 2|Bacteria M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel CMS1_k127_6210172_8 861299.J421_2757 5.844e-165 551.0 COG0215@1|root,COG0215@2|Bacteria,1ZT77@142182|Gemmatimonadetes 142182|Gemmatimonadetes J DALR_2 cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e CMS1_k127_6210172_18 1121875.KB907547_gene3471 1.223e-106 372.0 2C20F@1|root,32R9J@2|Bacteria,4P0SP@976|Bacteroidetes 976|Bacteroidetes S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 CMS1_k127_6210172_25 1379698.RBG1_1C00001G0295 1.226e-69 244.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - ko:K04013,ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_C552,Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1 CMS1_k127_6210172_22 1379698.RBG1_1C00001G0296 2.618e-86 305.0 COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 CMS1_k127_6210172_10 1379698.RBG1_1C00001G0297 8.931e-157 503.0 COG4881@1|root,COG4881@2|Bacteria 2|Bacteria - - cbcU - - - - - - - - - - - NrfD CMS1_k127_6210172_19 518766.Rmar_0040 5.122e-103 342.0 COG2126@1|root,COG2126@2|Bacteria,4NEX1@976|Bacteroidetes 976|Bacteroidetes J Pfam Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans CMS1_k127_6210172_32 402626.Rpic_2792 1.074e-49 200.0 COG0702@1|root,COG0702@2|Bacteria,1MZG7@1224|Proteobacteria,2VRAU@28216|Betaproteobacteria,1K8ZB@119060|Burkholderiaceae 28216|Betaproteobacteria GM NAD(P)H-binding - - - - - - - - - - - - NAD_binding_10 CMS1_k127_6210172_45 1410653.JHVC01000009_gene2682 7.081e-11 71.0 COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,36MSQ@31979|Clostridiaceae 186801|Clostridia CO redox-active disulfide protein 2 - - - - - - - - - - - - Thioredoxin_3 CMS1_k127_6210172_13 690850.Desaf_2160 9.694e-147 483.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,2M9VF@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 CMS1_k127_6210172_37 177439.DP0944 5.343e-29 123.0 COG0640@1|root,COG0640@2|Bacteria,1N19R@1224|Proteobacteria,42TRS@68525|delta/epsilon subdivisions,2WQHU@28221|Deltaproteobacteria,2MMGF@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_5 CMS1_k127_6210172_7 1267535.KB906767_gene800 2.402e-174 556.0 COG3345@1|root,COG3345@2|Bacteria,3Y98F@57723|Acidobacteria,2JP4Z@204432|Acidobacteriia 204432|Acidobacteriia G Melibiase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Melibiase_2,Melibiase_2_C CMS1_k127_6210172_5 861299.J421_1935 4.182e-237 756.0 COG2091@1|root,COG2091@2|Bacteria,1ZU9H@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - CMS1_k127_6210172_35 1313421.JHBV01000033_gene2422 6.072e-43 169.0 COG5587@1|root,COG5587@2|Bacteria,4NRNM@976|Bacteroidetes 976|Bacteroidetes S Conserved hypothetical protein (DUF2461) - - - - - - - - - - - - DUF2461 CMS1_k127_6210172_28 570952.ATVH01000013_gene2810 5.052e-52 193.0 COG3760@1|root,COG3760@2|Bacteria,1RDIG@1224|Proteobacteria,2U87T@28211|Alphaproteobacteria,2JSRQ@204441|Rhodospirillales 204441|Rhodospirillales S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit CMS1_k127_6210172_44 1442599.JAAN01000031_gene1396 2.355e-11 71.0 2ANYG@1|root,31DZF@2|Bacteria,1QB9H@1224|Proteobacteria,1T6TX@1236|Gammaproteobacteria,1X857@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - CMS1_k127_6210172_12 1123242.JH636434_gene3744 3.802e-152 505.0 COG1574@1|root,COG1574@2|Bacteria,2IXY4@203682|Planctomycetes 203682|Planctomycetes Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_3 CMS1_k127_6210172_16 1268237.G114_15186 2.846e-114 387.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1Y3DU@135624|Aeromonadales 135624|Aeromonadales L DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C CMS1_k127_6210172_9 1216967.L100_02138 2.75e-158 538.0 COG0383@1|root,COG0383@2|Bacteria,4NGF5@976|Bacteroidetes,1I6I3@117743|Flavobacteriia,34QAE@308865|Elizabethkingia 976|Bacteroidetes G Glycosyl hydrolases family 38 C-terminal domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Glyco_hydro_38,Glyco_hydro_38C CMS1_k127_6210172_2 1266914.ATUK01000011_gene2567 2.774e-310 995.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran CMS1_k127_6210172_30 187272.Mlg_0883 1.757e-50 205.0 COG0845@1|root,COG0845@2|Bacteria,1RD8U@1224|Proteobacteria,1S527@1236|Gammaproteobacteria,1WZ3Z@135613|Chromatiales 135613|Chromatiales M Biotin-lipoyl like - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS1_k127_6210172_3 309807.SRU_2765 1.31e-282 895.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,1FJ4M@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EU Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 CMS1_k127_6228933_0 379066.GAU_3626 1.141e-31 126.0 COG1538@1|root,COG1538@2|Bacteria,1ZUIP@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS1_k127_6228933_1 1379270.AUXF01000001_gene2699 5.009e-29 126.0 COG2138@1|root,COG2138@2|Bacteria,1ZUTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S CbiX - - - - - - - - - - - - CbiX CMS1_k127_6228933_4 1089545.KB913037_gene7386 0.0004021 47.0 COG3324@1|root,COG3324@2|Bacteria,2IRUY@201174|Actinobacteria,4E63A@85010|Pseudonocardiales 201174|Actinobacteria S PFAM Glyoxalase Bleomycin resistance protein Dioxygenase superfamily - - - ko:K06996 - - - - ko00000 - - - Glyoxalase CMS1_k127_6228933_3 45351.EDO49287 8.402e-06 58.0 KOG2177@1|root,KOG2177@2759|Eukaryota,38F95@33154|Opisthokonta 33154|Opisthokonta O tripartite motif containing 71, E3 ubiquitin protein ligase nhl-1 GO:0003008,GO:0003012,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007610,GO:0007626,GO:0008150,GO:0008152,GO:0008270,GO:0008345,GO:0009653,GO:0009987,GO:0010927,GO:0016043,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030537,GO:0031032,GO:0031674,GO:0032446,GO:0032501,GO:0032502,GO:0032989,GO:0036211,GO:0042592,GO:0042692,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0046716,GO:0046872,GO:0046914,GO:0048468,GO:0048646,GO:0048747,GO:0048856,GO:0048869,GO:0051146,GO:0055001,GO:0055002,GO:0060249,GO:0061061,GO:0065007,GO:0065008,GO:0070647,GO:0070925,GO:0071704,GO:0071840,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0140096,GO:1901564 2.3.2.27 ko:K11997,ko:K12035 ko05206,map05206 - - - ko00000,ko00001,ko01000,ko03019,ko04121 - - - NHL,zf-C3HC4,zf-RING_UBOX CMS1_k127_6228933_2 196162.Noca_3478 1.462e-07 62.0 COG3832@1|root,COG3832@2|Bacteria,2H678@201174|Actinobacteria,4DVPE@85009|Propionibacteriales 201174|Actinobacteria S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 CMS1_k127_6252649_1 518766.Rmar_1740 1.345e-92 309.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA CMS1_k127_6252649_0 1340493.JNIF01000003_gene3123 1.07e-107 360.0 COG1858@1|root,COG1858@2|Bacteria,3Y46D@57723|Acidobacteria 57723|Acidobacteria P Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C CMS1_k127_6252649_3 264732.Moth_1471 1.602e-23 115.0 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,249Y6@186801|Clostridia,42FQY@68295|Thermoanaerobacterales 186801|Clostridia T Diguanylate cyclase with GAF sensor - - - - - - - - - - - - GAF,GAF_2,GGDEF CMS1_k127_6252649_2 224911.27355297 3.09e-58 220.0 COG0642@1|root,COG0784@1|root,COG3447@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3447@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3JW8Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,dCache_1 CMS1_k127_6260820_5 1382356.JQMP01000003_gene2251 2.162e-12 73.0 COG1664@1|root,COG1664@2|Bacteria,2G7DZ@200795|Chloroflexi,27YJA@189775|Thermomicrobia 189775|Thermomicrobia M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin CMS1_k127_6260820_0 861299.J421_6223 1.623e-189 623.0 COG2091@1|root,COG2091@2|Bacteria,1ZUE3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - CMS1_k127_6260820_3 861299.J421_6107 2.795e-32 139.0 2CIH2@1|root,2ZTG0@2|Bacteria 2|Bacteria S Putative lumazine-binding - - - - - - - - - - - - Lumazine_bd_2 CMS1_k127_6260820_2 861299.J421_3651 1.111e-35 144.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated yqjI GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - PadR CMS1_k127_6260820_1 1123073.KB899242_gene1469 1.075e-98 343.0 COG0330@1|root,COG0330@2|Bacteria,1P8ZI@1224|Proteobacteria,1RUQU@1236|Gammaproteobacteria,1X4NG@135614|Xanthomonadales 135614|Xanthomonadales O membrane - - - - - - - - - - - - Band_7 CMS1_k127_6260820_4 1203605.HMPREF1531_00134 1.609e-12 71.0 COG4877@1|root,COG4877@2|Bacteria,2GQV1@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_6260820_7 309807.SRU_2724 3.632e-05 53.0 COG1073@1|root,COG1073@2|Bacteria,4NFRN@976|Bacteroidetes,1FJSE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S BAAT / Acyl-CoA thioester hydrolase C terminal - - - ko:K06889 - - - - ko00000 - - - BAAT_C,Hydrolase_4 CMS1_k127_6260820_6 886293.Sinac_0271 2.699e-05 54.0 COG1073@1|root,COG1073@2|Bacteria,2IYQ5@203682|Planctomycetes 203682|Planctomycetes S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 CMS1_k127_643192_8 1120971.AUCA01000026_gene630 5.97e-67 237.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H9SQ@91061|Bacilli,277Y5@186823|Alicyclobacillaceae 91061|Bacilli J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C CMS1_k127_643192_6 1047013.AQSP01000105_gene1436 1.73e-88 303.0 COG2421@1|root,COG2421@2|Bacteria,2NR72@2323|unclassified Bacteria 2|Bacteria C Acetamidase/Formamidase family - - - - - - - - - - - - FmdA_AmdA CMS1_k127_643192_11 861299.J421_2173 5.671e-34 147.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_2173|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_643192_9 234267.Acid_3440 3.887e-44 169.0 28NN4@1|root,2ZBNJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS1_k127_643192_7 1216966.BAUC01000019_gene856 1.204e-79 280.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RZAD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminotransferase hisC2 - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_643192_2 1128421.JAGA01000001_gene2203 2.397e-171 583.0 COG4579@1|root,COG4579@2|Bacteria 2|Bacteria F [isocitrate dehydrogenase (NADP+)] phosphatase activity aceK GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK CMS1_k127_643192_0 234267.Acid_3107 4.293e-236 742.0 COG2225@1|root,COG2225@2|Bacteria,3Y4MK@57723|Acidobacteria 57723|Acidobacteria C Belongs to the malate synthase family - - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase CMS1_k127_643192_1 1121013.P873_10470 1.901e-193 612.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria,1X3U8@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the reversible formation of glyoxylate and succinate from isocitrate aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL CMS1_k127_643192_5 861299.J421_2892 2.107e-96 329.0 COG1104@1|root,COG1104@2|Bacteria,1ZSXD@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class-V - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 CMS1_k127_643192_3 861299.J421_2891 2.447e-134 446.0 COG0482@1|root,COG0482@2|Bacteria,1ZST7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans CMS1_k127_643192_10 861299.J421_6034 1.381e-40 173.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS1_k127_643192_14 1267533.KB906742_gene675 4.537e-23 116.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria 57723|Acidobacteria K Tetratricopeptide repeat - - - - - - - - - - - - - CMS1_k127_643192_13 1121013.P873_09660 3.43e-24 116.0 COG2373@1|root,COG4625@1|root,COG2373@2|Bacteria,COG4625@2|Bacteria,1RDX6@1224|Proteobacteria,1S53I@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM outer membrane autotransporter barrel - - - - - - - - - - - - Autotransporter CMS1_k127_643192_4 861299.J421_3607 8.96e-100 331.0 COG0363@1|root,COG2120@1|root,COG0363@2|Bacteria,COG2120@2|Bacteria,1ZSQV@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase - - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso,PIG-L CMS1_k127_664187_2 1267533.KB906738_gene2351 1.25e-11 68.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C CMS1_k127_664187_1 1120934.KB894403_gene289 1.425e-34 153.0 COG1228@1|root,COG4946@1|root,COG1228@2|Bacteria,COG4946@2|Bacteria,2I3FC@201174|Actinobacteria,4EFCV@85010|Pseudonocardiales 201174|Actinobacteria Q WD40-like Beta Propeller Repeat - - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_664187_0 1254432.SCE1572_33175 5.702e-205 654.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WJ41@28221|Deltaproteobacteria,2YUJJ@29|Myxococcales 28221|Deltaproteobacteria S ABC transporter, ATP-binding protein ybiT - - - - - - - - - - - ABC_tran,ABC_tran_Xtn CMS1_k127_674841_2 1116232.AHBF01000080_gene8507 3.274e-18 98.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,2GMNT@201174|Actinobacteria 201174|Actinobacteria U Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,Amidohydro_3,PD40,TAT_signal CMS1_k127_674841_1 234267.Acid_4320 6.663e-85 293.0 COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria 57723|Acidobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C CMS1_k127_674841_0 234267.Acid_4321 6.211e-117 401.0 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - - - - - - - - - - - HATPase_c,HisKA CMS1_k127_676270_5 861299.J421_4087 1.426e-06 51.0 COG3408@1|root,COG3459@1|root,COG3408@2|Bacteria,COG3459@2|Bacteria 2|Bacteria G carbohydrate binding cbpA - 2.4.1.333 ko:K21298 - - - - ko00000,ko01000 - GH94 - BNR_2,F5_F8_type_C,Glyco_hydro_36,Glyco_transf_36,Trehalase CMS1_k127_676270_4 314275.MADE_1003105 6.96e-07 55.0 2E5P1@1|root,330DP@2|Bacteria,1N794@1224|Proteobacteria,1SD5J@1236|Gammaproteobacteria,468RV@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF2442) - - - - - - - - - - - - DUF2442 CMS1_k127_676270_3 861299.J421_0340 2.126e-13 81.0 COG3595@1|root,COG3595@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4097,PA14 CMS1_k127_676270_2 1223521.BBJX01000005_gene1890 2.397e-26 116.0 COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,2VQPE@28216|Betaproteobacteria,4ADGF@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM sigma-70 region 2 domain protein - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_676270_0 391603.FBALC1_09757 1.337e-57 225.0 COG1680@1|root,COG1729@1|root,COG1680@2|Bacteria,COG1729@2|Bacteria,4NGKK@976|Bacteroidetes,1HX0I@117743|Flavobacteriia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_676270_1 1429851.X548_13245 1.076e-30 140.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1S5WE@1236|Gammaproteobacteria,1X3ZI@135614|Xanthomonadales 135614|Xanthomonadales V beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS1_k127_67972_6 1379270.AUXF01000002_gene1586 1.599e-41 167.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_67972_1 1379270.AUXF01000002_gene1600 1.373e-181 602.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_67972_5 926690.KE386573_gene489 2.207e-42 169.0 COG0412@1|root,arCOG01659@2157|Archaea,2XZUN@28890|Euryarchaeota,23Z6A@183963|Halobacteria 183963|Halobacteria Q Dienelactone hydrolase family - - - - - - - - - - - - DLH CMS1_k127_67972_7 1082931.KKY_700 1.685e-11 70.0 COG0739@1|root,COG0739@2|Bacteria,1MXH6@1224|Proteobacteria,2U25J@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 CMS1_k127_67972_3 290397.Adeh_3929 3.937e-124 407.0 COG0266@1|root,COG0266@2|Bacteria,1MVHK@1224|Proteobacteria,43791@68525|delta/epsilon subdivisions,2X9X0@28221|Deltaproteobacteria,2YZTI@29|Myxococcales 28221|Deltaproteobacteria L Belongs to the FPG family - - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS CMS1_k127_67972_4 309807.SRU_0883 1.175e-95 333.0 COG0457@1|root,COG0457@2|Bacteria,4NFMI@976|Bacteroidetes,1FK5M@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 CMS1_k127_67972_0 861299.J421_1230 4.824e-205 673.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_67972_2 1379270.AUXF01000002_gene1600 4.498e-175 581.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_683365_1 1510531.JQJJ01000008_gene3890 1.041e-124 411.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,3JQQS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B CMS1_k127_683365_0 640081.Dsui_1936 1.998e-143 479.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2VJ4R@28216|Betaproteobacteria,2KV5W@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 CMS1_k127_683365_3 877455.Metbo_1591 5.495e-17 96.0 COG0784@1|root,COG3413@1|root,arCOG02348@1|root,arCOG06712@1|root,arCOG02276@2157|Archaea,arCOG02348@2157|Archaea,arCOG06537@2157|Archaea,arCOG06712@2157|Archaea 2157|Archaea T PAS domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg CMS1_k127_683365_4 1121090.KB894726_gene1290 1.057e-10 66.0 2DGK2@1|root,2ZWBC@2|Bacteria,1W4NY@1239|Firmicutes,4IMUS@91061|Bacilli,1ZKVY@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - CMS1_k127_683365_2 1122244.AUGF01000070_gene953 4.239e-20 90.0 2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,1SDC6@1236|Gammaproteobacteria,3NRXM@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_683365_5 1232437.KL662077_gene1904 3.358e-09 58.0 2AEBV@1|root,3146B@2|Bacteria,1PTMA@1224|Proteobacteria,432JB@68525|delta/epsilon subdivisions,2WXR3@28221|Deltaproteobacteria,2MP7D@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_685816_7 627192.SLG_02320 1.052e-116 398.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,2K0GD@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N CMS1_k127_685816_12 861299.J421_3897 5.752e-100 336.0 COG0501@1|root,COG0501@2|Bacteria,1ZT2E@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 CMS1_k127_685816_2 861299.J421_3896 1.056e-166 533.0 COG0626@1|root,COG0626@2|Bacteria,1ZT9F@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.1 ko:K01758 ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230 M00338 R00782,R01001,R02408,R04770,R04930,R09366 RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP CMS1_k127_685816_3 1379270.AUXF01000003_gene3498 7.713e-159 515.0 COG1109@1|root,COG1109@2|Bacteria,1ZSNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS1_k127_685816_0 861299.J421_3893 3.236e-253 797.0 COG0449@1|root,COG0449@2|Bacteria,1ZSTI@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS CMS1_k127_685816_20 1397699.JNIS01000001_gene636 8.557e-51 184.0 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,3WEU3@539002|Bacillales incertae sedis 91061|Bacilli J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase CMS1_k127_685816_19 861299.J421_3871 2.715e-52 193.0 COG0424@1|root,COG0424@2|Bacteria,1ZTP7@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf CMS1_k127_685816_8 379066.GAU_2417 5.872e-110 393.0 COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1ZT7U@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - FHA,GAF,Guanylate_cyc CMS1_k127_685816_5 379066.GAU_2416 2.135e-135 451.0 COG0147@1|root,COG0147@2|Bacteria,1ZSPU@142182|Gemmatimonadetes 142182|Gemmatimonadetes EH Anthranilate synthase component I, N terminal region trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind CMS1_k127_685816_9 861299.J421_3866 1.25e-107 381.0 2EWAK@1|root,33PPB@2|Bacteria,1ZT00@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_685816_4 880073.Calab_3640 1.543e-149 501.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N CMS1_k127_685816_15 1521187.JPIM01000051_gene3470 1.026e-79 296.0 COG0745@1|root,COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg CMS1_k127_685816_11 861299.J421_3861 9.088e-104 345.0 COG0110@1|root,COG0110@2|Bacteria 2|Bacteria S O-acyltransferase activity - - - - - - - - - - - - Hexapep,Hexapep_2 CMS1_k127_685816_22 1385515.N791_12215 2.672e-39 160.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1X42D@135614|Xanthomonadales 135614|Xanthomonadales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE CMS1_k127_685816_14 1121920.AUAU01000019_gene2603 1.323e-95 342.0 COG2433@1|root,COG2433@2|Bacteria 2|Bacteria - - - - - ko:K12065 - - - - ko00000,ko02044 3.A.7.11.1 - - Porin_O_P CMS1_k127_685816_25 1121920.AUAU01000019_gene2604 5.722e-26 124.0 COG4659@1|root,COG4659@2|Bacteria 2|Bacteria C FMN binding rnfG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03612 - - - - ko00000 - - - FMN_bind CMS1_k127_685816_24 861299.J421_3859 7.94e-31 136.0 2F4EZ@1|root,33X55@2|Bacteria,1ZTSQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_685816_23 1380763.BG53_15930 3.297e-37 160.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,4HBXZ@91061|Bacilli,26RHP@186822|Paenibacillaceae 91061|Bacilli D Necessary for normal cell division and for the maintenance of normal septation engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 CMS1_k127_685816_1 861299.J421_3856 1.969e-214 671.0 COG1219@1|root,COG1219@2|Bacteria,1ZT8F@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX CMS1_k127_685816_16 584708.Apau_1398 2.697e-78 274.0 COG0740@1|root,COG0740@2|Bacteria,3T9R6@508458|Synergistetes 508458|Synergistetes O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease CMS1_k127_685816_6 861299.J421_3854 4.811e-118 392.0 COG0544@1|root,COG0544@2|Bacteria,1ZSSF@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig - - ko:K03545 - - - - ko00000 - - - Trigger_C,Trigger_N CMS1_k127_685816_13 216594.MMAR_3322 2.939e-97 328.0 COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,233TJ@1762|Mycobacteriaceae 201174|Actinobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C CMS1_k127_685816_17 1108045.GORHZ_125_00290 6.034e-63 239.0 COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4GBU0@85026|Gordoniaceae 201174|Actinobacteria C Dehydrogenase E1 component acoA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh CMS1_k127_685816_21 1346791.M529_21955 3.855e-44 184.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria,2KEB5@204457|Sphingomonadales 204457|Sphingomonadales QU amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3,PD40 CMS1_k127_685816_10 861299.J421_5759 2.086e-104 355.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_685816_18 1185876.BN8_01449 1.556e-57 207.0 COG3403@1|root,COG3403@2|Bacteria,4PNZ7@976|Bacteroidetes,47YRG@768503|Cytophagia 976|Bacteroidetes S YqcI/YcgG family - - - - - - - - - - - - - CMS1_k127_697509_3 483219.LILAB_33785 5.791e-25 111.0 COG0640@1|root,COG0640@2|Bacteria,1QVFX@1224|Proteobacteria 1224|Proteobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - HTH_34 CMS1_k127_697509_4 1047013.AQSP01000058_gene2028 1.832e-15 89.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,TolB_like CMS1_k127_697509_5 1131269.AQVV01000013_gene1749 3.808e-05 56.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - 3.2.1.81 ko:K01219 - - - - ko00000,ko01000 - - - CotH CMS1_k127_697509_0 1158345.JNLL01000001_gene544 1.225e-194 618.0 COG0422@1|root,COG0422@2|Bacteria,2G3RS@200783|Aquificae 200783|Aquificae H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM CMS1_k127_697509_1 316067.Geob_0102 1.429e-40 157.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,42SCH@68525|delta/epsilon subdivisions,2WPMA@28221|Deltaproteobacteria,43SR2@69541|Desulfuromonadales 28221|Deltaproteobacteria S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 CMS1_k127_697509_2 1169161.KB897737_gene2445 6.745e-35 139.0 COG0242@1|root,COG0242@2|Bacteria 2|Bacteria J peptide deformylase activity - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - HTH_31,Pep_deformylase CMS1_k127_697823_0 1168034.FH5T_04755 1.316e-248 784.0 COG1509@1|root,COG1509@2|Bacteria,4NK6C@976|Bacteroidetes,2FMW5@200643|Bacteroidia 976|Bacteroidetes E KamA family eam - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - - CMS1_k127_697823_1 1382304.JNIL01000001_gene3057 5.584e-76 268.0 COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,4HADV@91061|Bacilli 91061|Bacilli J Alanyl-tRNA synthetase alaS_2 - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS1_k127_73089_0 518766.Rmar_1363 2.874e-258 814.0 COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes 976|Bacteroidetes M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS1_k127_73089_1 1499967.BAYZ01000036_gene2419 1.14e-19 93.0 COG2152@1|root,COG2152@2|Bacteria,2NPB8@2323|unclassified Bacteria 2|Bacteria G beta-1,4-mannooligosaccharide phosphorylase - - - - - - - - - - - - Glyco_hydro_130 CMS1_k127_783787_5 309807.SRU_2724 2.249e-10 63.0 COG1073@1|root,COG1073@2|Bacteria,4NFRN@976|Bacteroidetes,1FJSE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S BAAT / Acyl-CoA thioester hydrolase C terminal - - - ko:K06889 - - - - ko00000 - - - BAAT_C,Hydrolase_4 CMS1_k127_783787_2 76114.ebA6371 8.29e-76 256.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VR39@28216|Betaproteobacteria,2KXCP@206389|Rhodocyclales 206389|Rhodocyclales S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP CMS1_k127_783787_1 1121930.AQXG01000001_gene1586 1.715e-116 391.0 COG1680@1|root,COG1680@2|Bacteria,4NGKK@976|Bacteroidetes,1IRV5@117747|Sphingobacteriia 976|Bacteroidetes V COG1680 Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase,DUF3471,TPR_2 CMS1_k127_783787_0 1123242.JH636434_gene5621 6.913e-190 609.0 COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 CMS1_k127_783787_4 1500259.JQLD01000005_gene108 5.362e-37 152.0 COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,2U39G@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Esterase PHB depolymerase - - - ko:K03932 - - - - ko00000 - CE1 - Abhydrolase_2,Esterase_phd CMS1_k127_783787_3 1379270.AUXF01000007_gene968 3.237e-47 179.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene968|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_784402_6 390989.JOEG01000013_gene2394 7.422e-15 88.0 COG0596@1|root,COG0596@2|Bacteria,2I2VI@201174|Actinobacteria,4DDQN@85008|Micromonosporales 201174|Actinobacteria S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 CMS1_k127_784402_5 1047013.AQSP01000131_gene1844 1.692e-15 89.0 COG1238@1|root,COG1238@2|Bacteria 2|Bacteria I metal cluster binding yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - SNARE_assoc CMS1_k127_784402_4 1298863.AUEP01000003_gene3076 1.971e-45 177.0 2B7FS@1|root,320JK@2|Bacteria,2H4AH@201174|Actinobacteria,4DUBC@85009|Propionibacteriales 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_784402_1 485918.Cpin_1364 1.668e-72 261.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS1_k127_784402_0 485918.Cpin_1363 6.002e-129 437.0 COG2303@1|root,COG2303@2|Bacteria,4NEF2@976|Bacteroidetes,1IXR8@117747|Sphingobacteriia 976|Bacteroidetes E GMC oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 CMS1_k127_784402_3 861299.J421_2170 8.146e-46 191.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_784402_2 861299.J421_6034 1.238e-50 192.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS1_k127_805224_14 1442599.JAAN01000015_gene3272 1.511e-74 255.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1X3VS@135614|Xanthomonadales 135614|Xanthomonadales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran CMS1_k127_805224_21 1278073.MYSTI_07104 5.596e-39 153.0 COG1595@1|root,COG1595@2|Bacteria,1RBM4@1224|Proteobacteria,42S7N@68525|delta/epsilon subdivisions 1224|Proteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_805224_1 637390.AFOH01000140_gene1240 6.525e-284 891.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1S1ID@1236|Gammaproteobacteria,2NC8Z@225057|Acidithiobacillales 225057|Acidithiobacillales P copper-translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase CMS1_k127_805224_13 935863.AWZR01000007_gene259 8.056e-75 258.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1X3XJ@135614|Xanthomonadales 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm2 - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS1_k127_805224_15 1265313.HRUBRA_00432 3.212e-72 264.0 COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,1T0QH@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG4257 Streptogramin lyase - - - - - - - - - - - - CarboxypepD_reg CMS1_k127_805224_12 335543.Sfum_2496 1.269e-78 269.0 COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria,42MIS@68525|delta/epsilon subdivisions,2WMK7@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like CMS1_k127_805224_18 338963.Pcar_2373 1.199e-49 194.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42QGA@68525|delta/epsilon subdivisions,2WJYS@28221|Deltaproteobacteria,43S8F@69541|Desulfuromonadales 28221|Deltaproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_805224_19 314345.SPV1_00757 8.945e-46 187.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria 1224|Proteobacteria M ABC-type transport system involved in lipoprotein release permease component VPA0558 - - - - - - - - - - - FtsX,MacB_PCD CMS1_k127_805224_16 518766.Rmar_2536 2.809e-69 248.0 COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,1FIVB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_805224_26 439235.Dalk_0592 8.722e-22 109.0 2C2F5@1|root,32WND@2|Bacteria,1ND6R@1224|Proteobacteria,42Q4T@68525|delta/epsilon subdivisions,2WK9F@28221|Deltaproteobacteria,2MHXS@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_805224_7 861299.J421_4002 8.122e-106 357.0 COG0389@1|root,COG0389@2|Bacteria,1ZT65@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C CMS1_k127_805224_0 945713.IALB_3112 0.0 1294.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria 2|Bacteria M serine-type peptidase activity - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ CMS1_k127_805224_8 1192034.CAP_6426 2.792e-87 299.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YZAP@29|Myxococcales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS1_k127_805224_9 314278.NB231_02593 3.166e-85 287.0 COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,1RZBF@1236|Gammaproteobacteria,1X0F6@135613|Chromatiales 135613|Chromatiales Q PFAM isochorismatase hydrolase - - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase CMS1_k127_805224_5 861299.J421_2170 2.203e-116 392.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_805224_4 713586.KB900536_gene1317 8.305e-133 432.0 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1WZYG@135613|Chromatiales 135613|Chromatiales G Fructose-bisphosphate aldolase class-I - - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic CMS1_k127_805224_23 861299.J421_2432 1.041e-26 117.0 COG1595@1|root,COG1595@2|Bacteria,1ZT0A@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_805224_27 448385.sce8791 0.0002357 51.0 2AGZU@1|root,3178K@2|Bacteria,1PYIG@1224|Proteobacteria,43E50@68525|delta/epsilon subdivisions,2WZR6@28221|Deltaproteobacteria,2Z2JU@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_805224_6 869210.Marky_0713 4.966e-114 382.0 COG0346@1|root,COG0346@2|Bacteria,1WICF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E glyoxalase bleomycin resistance protein dioxygenase - - - ko:K15975 - - - - ko00000 - - - Glyoxalase CMS1_k127_805224_2 861299.J421_1729 1.972e-164 551.0 COG0515@1|root,COG0515@2|Bacteria,1ZUCF@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_805224_20 1379270.AUXF01000001_gene2219 1.177e-43 166.0 COG2771@1|root,COG2771@2|Bacteria 2|Bacteria K luxR family - - - - - - - - - - - - GerE CMS1_k127_805224_3 1121104.AQXH01000001_gene1400 2.306e-153 509.0 COG0624@1|root,COG0624@2|Bacteria,4NEA7@976|Bacteroidetes,1IWTY@117747|Sphingobacteriia 976|Bacteroidetes E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS1_k127_805224_24 861299.J421_1988 2.513e-25 117.0 COG0428@1|root,COG0428@2|Bacteria 861299.J421_1988|- P transporter - - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - - CMS1_k127_805224_11 861299.J421_1987 3.588e-81 288.0 COG0428@1|root,COG0428@2|Bacteria 2|Bacteria P transporter - - - - - - - - - - - - Zip CMS1_k127_805224_10 379066.GAU_2111 1.068e-82 281.0 COG0231@1|root,COG0231@2|Bacteria,1ZT2N@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C CMS1_k127_805224_22 266117.Rxyl_2877 1.32e-37 148.0 COG1246@1|root,COG1246@2|Bacteria 2|Bacteria E Belongs to the acetyltransferase family. ArgA subfamily ywlB - 2.3.1.1 ko:K00619 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,C_GCAxxG_C_C CMS1_k127_805224_17 234267.Acid_4804 7.573e-67 237.0 COG2008@1|root,COG2008@2|Bacteria,3Y7Q8@57723|Acidobacteria 57723|Acidobacteria E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS1_k127_806397_5 379066.GAU_0898 3.161e-21 102.0 COG2318@1|root,COG2318@2|Bacteria,1ZU3G@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DinB superfamily - - - - - - - - - - - - DinB_2 CMS1_k127_806397_8 215803.DB30_6268 0.0002478 55.0 2BIM8@1|root,32CU6@2|Bacteria,1P1YI@1224|Proteobacteria,4353N@68525|delta/epsilon subdivisions,2WZEN@28221|Deltaproteobacteria,2Z1Z6@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS1_k127_806397_4 1382306.JNIM01000001_gene1216 1.084e-43 165.0 COG0251@1|root,COG0251@2|Bacteria 2|Bacteria J oxidation-reduction process - - - - - - - - - - - - Aldo_ket_red,Ribonuc_L-PSP CMS1_k127_806397_1 861299.J421_6359 2.702e-137 467.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6359|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS1_k127_806397_3 644283.Micau_3984 5.048e-45 171.0 COG0500@1|root,COG0500@2|Bacteria,2I43G@201174|Actinobacteria,4DJ41@85008|Micromonosporales 201174|Actinobacteria Q Methyltransferase domain - - 2.1.1.235 ko:K13307 ko00523,ko01130,map00523,map01130 M00796 R06439 RC00003,RC01515 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_25 CMS1_k127_806397_6 324057.Pjdr2_0502 3.401e-16 80.0 COG1476@1|root,COG1476@2|Bacteria,1VEKB@1239|Firmicutes,4IQ1D@91061|Bacilli,2765W@186822|Paenibacillaceae 91061|Bacilli K Helix-turn-helix XRE-family like proteins - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 CMS1_k127_806397_7 1206732.BAGD01000272_gene6050 5.074e-06 57.0 2E0MB@1|root,32W6J@2|Bacteria,2IR53@201174|Actinobacteria,4FZRV@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - CMS1_k127_806397_2 700598.Niako_6465 2.656e-131 433.0 COG1680@1|root,COG1680@2|Bacteria,4NGZR@976|Bacteroidetes,1ISPB@117747|Sphingobacteriia 976|Bacteroidetes V COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - - - - - - - - - - Beta-lactamase CMS1_k127_806397_0 502025.Hoch_4094 3.152e-141 466.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2YY4H@29|Myxococcales 28221|Deltaproteobacteria M PFAM glycosyl transferase group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 CMS1_k127_81587_0 525897.Dbac_0439 5.741e-69 261.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,43ADQ@68525|delta/epsilon subdivisions,2X5TK@28221|Deltaproteobacteria,2MAD4@213115|Desulfovibrionales 28221|Deltaproteobacteria K Alanine-glyoxylate amino-transferase - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR CMS1_k127_81587_1 379066.GAU_3332 9.57e-62 239.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2,DDE_Tnp_1_4 CMS1_k127_847854_3 1379270.AUXF01000006_gene112 1.309e-24 103.0 COG4799@1|root,COG4799@2|Bacteria,1ZTGE@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Carboxyl transferase domain - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans CMS1_k127_847854_0 379066.GAU_1782 2.441e-182 584.0 COG0439@1|root,COG0439@2|Bacteria,1ZTBD@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS1_k127_847854_1 861299.J421_3416 9.592e-75 267.0 COG2265@1|root,COG2265@2|Bacteria,1ZSPC@142182|Gemmatimonadetes 142182|Gemmatimonadetes H tRNA (Uracil-5-)-methyltransferase - - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr CMS1_k127_847854_2 861299.J421_3415 5.914e-30 130.0 COG4770@1|root,COG4770@2|Bacteria,1ZTVQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin-requiring enzyme - - - - - - - - - - - - Biotin_lipoyl CMS1_k127_847854_4 1089455.MOPEL_069_00280 8.065e-19 87.0 COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4F6TR@85018|Dermatophilaceae 201174|Actinobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 CMS1_k127_89156_1 1379270.AUXF01000002_gene1587 4.241e-21 94.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1587|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_89156_0 1379270.AUXF01000002_gene1600 2.285e-114 395.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS1_k127_913375_9 335543.Sfum_0655 1.169e-22 106.0 COG4191@1|root,COG4191@2|Bacteria,1NC2K@1224|Proteobacteria,42WDG@68525|delta/epsilon subdivisions,2WRNM@28221|Deltaproteobacteria,2MS4V@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HisKA CMS1_k127_913375_4 706587.Desti_4443 1.549e-44 173.0 COG2204@1|root,COG2204@2|Bacteria,1QUMA@1224|Proteobacteria,43BKZ@68525|delta/epsilon subdivisions,2X6Z5@28221|Deltaproteobacteria 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - Response_reg CMS1_k127_913375_7 1121439.dsat_2571 6.357e-34 142.0 COG0745@1|root,COG0745@2|Bacteria,1NE8H@1224|Proteobacteria,42NEH@68525|delta/epsilon subdivisions,2WK1M@28221|Deltaproteobacteria,2M7RK@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Cytidylate_kin2,Response_reg CMS1_k127_913375_2 439235.Dalk_2933 8.701e-143 473.0 COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MHP3@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 CMS1_k127_913375_8 1121448.DGI_0543 7.733e-31 129.0 COG0745@1|root,COG0745@2|Bacteria,1MZGI@1224|Proteobacteria,42UM3@68525|delta/epsilon subdivisions,2WR2K@28221|Deltaproteobacteria,2MC1R@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg CMS1_k127_913375_6 439235.Dalk_2936 2.984e-36 148.0 COG2204@1|root,COG2204@2|Bacteria,1RHEG@1224|Proteobacteria,42T1C@68525|delta/epsilon subdivisions,2WP30@28221|Deltaproteobacteria,2MK48@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg CMS1_k127_913375_10 767817.Desgi_1160 5.485e-11 70.0 COG0517@1|root,COG0517@2|Bacteria,1V4ME@1239|Firmicutes,24HXH@186801|Clostridia,262IW@186807|Peptococcaceae 186801|Clostridia S signal-transduction protein containing cAMP-binding and CBS domains - - - - - - - - - - - - CBS CMS1_k127_913375_1 1265505.ATUG01000001_gene2868 2.397e-194 634.0 COG1055@1|root,COG1055@2|Bacteria,1QUC0@1224|Proteobacteria,42NUZ@68525|delta/epsilon subdivisions,2WJNH@28221|Deltaproteobacteria,2MPNS@213118|Desulfobacterales 28221|Deltaproteobacteria P Sodium:sulfate symporter transmembrane region - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp CMS1_k127_913375_5 1293054.HSACCH_01748 8.535e-37 160.0 COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia,3WAK7@53433|Halanaerobiales 186801|Clostridia K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N CMS1_k127_913375_3 1121423.JONT01000001_gene2038 8.118e-56 204.0 COG1146@1|root,COG1146@2|Bacteria,1V59C@1239|Firmicutes,24J64@186801|Clostridia,261U8@186807|Peptococcaceae 186801|Clostridia C reductase beta subunit - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4_7,Fer4_9 CMS1_k127_913375_0 1121430.JMLG01000003_gene656 2.823e-314 972.0 COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia,25ZZD@186807|Peptococcaceae 186801|Clostridia C reductase alpha subunit - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS1_k127_916564_4 882082.SaccyDRAFT_2627 5.312e-24 117.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,2GMNT@201174|Actinobacteria,4DYP4@85010|Pseudonocardiales 201174|Actinobacteria QU Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,PD40 CMS1_k127_916564_3 861299.J421_5759 4.611e-101 347.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_916564_0 234267.Acid_4902 7.663e-281 887.0 COG5549@1|root,COG5549@2|Bacteria,3Y2IY@57723|Acidobacteria 57723|Acidobacteria O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 CMS1_k127_916564_5 861299.J421_1545 0.0002876 48.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS1_k127_916564_2 384765.SIAM614_09163 5.74e-104 352.0 COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,2TUF8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Fatty acid desaturase des - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase CMS1_k127_916564_1 861299.J421_3663 1.193e-167 540.0 COG1228@1|root,COG1228@2|Bacteria,1ZSU7@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS1_k127_92124_16 761193.Runsl_2417 6.098e-31 124.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NFTM@976|Bacteroidetes,47NS1@768503|Cytophagia 976|Bacteroidetes EU Dienelactone hydrolase family - - - - - - - - - - - - DPPIV_N,PD40,Peptidase_S9 CMS1_k127_92124_12 452637.Oter_1692 1.606e-50 201.0 COG1520@1|root,COG1520@2|Bacteria,46T0C@74201|Verrucomicrobia,3K9Y4@414999|Opitutae 2|Bacteria S PFAM Pyrrolo-quinoline quinone - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PQQ_2,PQQ_3,Pkinase CMS1_k127_92124_26 861299.J421_6371 2.42e-06 59.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6371|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_92124_17 861299.J421_3045 2.05e-25 107.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 861299.J421_3045|- KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_92124_18 1248916.ANFY01000003_gene838 8.259e-22 104.0 COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,2UFAC@28211|Alphaproteobacteria,2K6I4@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF454) - - - ko:K09790 - - - - ko00000 - - - DUF454 CMS1_k127_92124_0 1173024.KI912148_gene4571 7.653e-300 938.0 COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1JMTM@1189|Stigonemataceae 1117|Cyanobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N CMS1_k127_92124_7 671143.DAMO_0966 6.316e-69 241.0 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 spoIVFB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K06212,ko:K06402 - - - - ko00000,ko01000,ko01002,ko02000 1.A.16.1.1,1.A.16.1.3 - - CBS,Form_Nir_trans,Peptidase_M50 CMS1_k127_92124_1 1210884.HG799464_gene10982 1.176e-165 537.0 COG1236@1|root,COG1236@2|Bacteria,2IXNS@203682|Planctomycetes 203682|Planctomycetes J Exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL CMS1_k127_92124_21 335659.S23_36670 7.388e-15 81.0 COG0517@1|root,COG0517@2|Bacteria,1Q3MX@1224|Proteobacteria,2U4RB@28211|Alphaproteobacteria,3JYGU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - BON,CBS CMS1_k127_92124_2 246197.MXAN_5426 6.468e-155 518.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,2YZRQ@29|Myxococcales 28221|Deltaproteobacteria S tRNA-splicing ligase RtcB rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB CMS1_k127_92124_23 1232410.KI421412_gene149 1.145e-12 74.0 COG1371@1|root,COG1371@2|Bacteria,1NCP6@1224|Proteobacteria,42VQE@68525|delta/epsilon subdivisions,2WS6C@28221|Deltaproteobacteria,43VMN@69541|Desulfuromonadales 28221|Deltaproteobacteria S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease CMS1_k127_92124_15 351607.Acel_0042 3.408e-33 133.0 COG1765@1|root,COG1765@2|Bacteria,2HA74@201174|Actinobacteria 201174|Actinobacteria O OsmC-like protein - - - - - - - - - - - - OsmC CMS1_k127_92124_22 1415780.JPOG01000001_gene953 9.448e-15 85.0 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1X94A@135614|Xanthomonadales 135614|Xanthomonadales T Universal stress protein family - - - - - - - - - - - - Usp CMS1_k127_92124_10 671143.DAMO_3124 7.447e-66 242.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,SpoIIE,sCache_3_2 CMS1_k127_92124_8 314345.SPV1_12687 1.524e-68 240.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria 1224|Proteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C CMS1_k127_92124_13 1349767.GJA_856 2.678e-47 192.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2VM9P@28216|Betaproteobacteria,472CK@75682|Oxalobacteraceae 1224|Proteobacteria T Member of a two-component regulatory system - - 2.7.13.3 ko:K02484,ko:K07644,ko:K07645,ko:K18143 ko01501,ko02020,ko02024,map01501,map02020,map02024 M00452,M00453,M00649,M00655,M00745 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - 2CSK_N,HAMP,HATPase_c,HisKA CMS1_k127_92124_5 1191523.MROS_0148 2.826e-90 312.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - ko:K22110 - - - - ko00000,ko02000 1.B.35.1,1.B.35.2 - - MtrB_PioB,OMP_b-brl,OMP_b-brl_2 CMS1_k127_92124_20 395965.Msil_1406 3.052e-18 90.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,3N9Q5@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - Cytochrome_CBB3,GSDH CMS1_k127_92124_28 1123368.AUIS01000041_gene4 6.231e-05 55.0 COG3746@1|root,COG3746@2|Bacteria 2|Bacteria - - - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P CMS1_k127_92124_25 265072.Mfla_0632 1.638e-06 59.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,2KMD1@206350|Nitrosomonadales 206350|Nitrosomonadales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N CMS1_k127_92124_24 1123024.AUII01000022_gene129 8.107e-10 72.0 COG2197@1|root,COG2197@2|Bacteria,2I321@201174|Actinobacteria,4EF7G@85010|Pseudonocardiales 201174|Actinobacteria KT AAA ATPase domain - - - - - - - - - - - - AAA_16,GerE CMS1_k127_92124_19 1245469.S58_69060 1.795e-18 101.0 COG2267@1|root,COG3629@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,1NIJG@1224|Proteobacteria,2U09P@28211|Alphaproteobacteria,3JTK8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IT Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,BTAD,Hydrolase_4,Trans_reg_C CMS1_k127_92124_14 629265.PMA4326_26462 7.781e-41 175.0 COG0515@1|root,COG2304@1|root,COG0515@2|Bacteria,COG2304@2|Bacteria,1MXU0@1224|Proteobacteria,1T1GT@1236|Gammaproteobacteria,1ZAJ6@136849|Pseudomonas syringae group 1236|Gammaproteobacteria KLT Protein tyrosine kinase ppkA - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - Pkinase CMS1_k127_92124_11 1042163.BRLA_c027510 3.237e-62 221.0 COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,4HBM0@91061|Bacilli,26QI7@186822|Paenibacillaceae 91061|Bacilli S Catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins ytkL - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 CMS1_k127_92124_6 1254432.SCE1572_51690 5.095e-86 303.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,42PGW@68525|delta/epsilon subdivisions,2WMMZ@28221|Deltaproteobacteria,2YUHA@29|Myxococcales 28221|Deltaproteobacteria C NAD(P)H quinone oxidoreductase, PIG3 family - - - - - - - - - - - - ADH_N,ADH_zinc_N CMS1_k127_92124_4 652103.Rpdx1_4223 6.58e-111 376.0 COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,2TR16@28211|Alphaproteobacteria,3JUPA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M mandelate racemase muconate lactonizing ycjG GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N CMS1_k127_92124_9 1379270.AUXF01000002_gene1577 3.217e-68 261.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_92124_3 1379270.AUXF01000005_gene643 4.782e-116 385.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZTF0@142182|Gemmatimonadetes 142182|Gemmatimonadetes EU Acetyl xylan esterase (AXE1) - - - - - - - - - - - - PD40,Peptidase_S9 CMS1_k127_929218_0 518766.Rmar_0489 7.157e-193 617.0 COG3934@1|root,COG3934@2|Bacteria,4NFVS@976|Bacteroidetes 976|Bacteroidetes G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - - - - - - - - - - Cellulase CMS1_k127_937761_26 861299.J421_4331 1.142e-15 78.0 COG1234@1|root,COG1234@2|Bacteria,1ZTG7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 CMS1_k127_937761_28 880071.Fleli_0557 7.586e-15 86.0 COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,47MMF@768503|Cytophagia 976|Bacteroidetes Q Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS1_k127_937761_13 1519464.HY22_06300 8.245e-66 235.0 COG1127@1|root,COG1127@2|Bacteria,1FEH4@1090|Chlorobi 1090|Chlorobi Q ATPases associated with a variety of cellular activities - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran CMS1_k127_937761_11 1379270.AUXF01000004_gene3070 2.636e-69 254.0 COG1194@1|root,COG1194@2|Bacteria,1ZTNM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L FES - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD CMS1_k127_937761_16 1379270.AUXF01000001_gene2818 7.672e-51 192.0 COG0767@1|root,COG0767@2|Bacteria,1ZSUC@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS1_k127_937761_22 861299.J421_4333 2.988e-27 121.0 COG4911@1|root,COG4911@2|Bacteria 2|Bacteria S Uncharacterized conserved protein (DUF2203) - - - - - - - - - - - - DUF2203 CMS1_k127_937761_25 1385521.N803_14855 4.706e-21 107.0 COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,4FETQ@85021|Intrasporangiaceae 201174|Actinobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin CMS1_k127_937761_15 1379270.AUXF01000001_gene2675 5.561e-56 200.0 COG1607@1|root,COG1607@2|Bacteria,1ZTQ1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thioesterase superfamily - - - - - - - - - - - - 4HBT CMS1_k127_937761_1 379066.GAU_2785 9.93e-204 649.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1ZTC2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H NAD synthase - - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase CMS1_k127_937761_4 861299.J421_2683 7.121e-132 438.0 COG0747@1|root,COG0747@2|Bacteria,1ZTBU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 CMS1_k127_937761_20 1379270.AUXF01000001_gene2769 1.4e-33 139.0 2A1DQ@1|root,30PKX@2|Bacteria,1ZUYB@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_937761_23 1379270.AUXF01000001_gene2769 1.985e-21 105.0 2A1DQ@1|root,30PKX@2|Bacteria,1ZUYB@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS1_k127_937761_6 861299.J421_0829 4.858e-116 389.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - GAF,HTH_8,Sigma54_activat CMS1_k127_937761_24 861299.J421_0830 2.302e-21 107.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_0830|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_937761_2 861299.J421_2200 3.002e-200 632.0 COG0673@1|root,COG0673@2|Bacteria,1ZSRB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA CMS1_k127_937761_10 1121430.JMLG01000007_gene2535 9.043e-75 271.0 COG2998@1|root,COG2998@2|Bacteria,1TQA9@1239|Firmicutes,249EZ@186801|Clostridia,2605W@186807|Peptococcaceae 186801|Clostridia H PBP superfamily domain tupA - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 CMS1_k127_937761_9 861299.J421_4352 7.032e-90 304.0 COG1801@1|root,COG1801@2|Bacteria 2|Bacteria L Protein of unknown function DUF72 yecE - - - - - - - - - - - DUF72 CMS1_k127_937761_29 875328.JDM601_1538 3.037e-11 68.0 2AVHB@1|root,31M9R@2|Bacteria,2IMW9@201174|Actinobacteria,23A76@1762|Mycobacteriaceae 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 CMS1_k127_937761_19 257310.BB3383 7.03e-40 166.0 COG1250@1|root,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2VJ64@28216|Betaproteobacteria,3T24A@506|Alcaligenaceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase - - - - - - - - - - - - 3HCDH,3HCDH_N CMS1_k127_937761_7 479434.Sthe_3148 1.321e-109 379.0 COG0428@1|root,COG0428@2|Bacteria,2G9IR@200795|Chloroflexi 200795|Chloroflexi P transporter - - - - - - - - - - - - - CMS1_k127_937761_5 1459636.NTE_01395 1.771e-116 386.0 COG2132@1|root,arCOG03914@2157|Archaea,41S77@651137|Thaumarchaeota 651137|Thaumarchaeota Q PFAM Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_937761_12 861299.J421_4361 2.376e-67 236.0 COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1ZTHJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix diphteria tox regulatory element - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress,FeoA CMS1_k127_937761_21 1379270.AUXF01000001_gene2642 3.829e-33 135.0 COG1051@1|root,COG1051@2|Bacteria,1ZU0E@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NUDIX domain - - - - - - - - - - - - NUDIX CMS1_k127_937761_17 880073.Calab_0866 2.298e-50 189.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity luxD - 3.2.1.4,4.2.99.18 ko:K01179,ko:K06889,ko:K10773,ko:K15853 ko00500,ko01100,ko02020,ko02024,ko03410,map00500,map01100,map02020,map02024,map03410 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko03400 - GH5,GH9 - Abhydrolase_1,Acyl_transf_2,DLH,Hydrolase_4,Peptidase_S9 CMS1_k127_937761_8 1125863.JAFN01000001_gene207 6.395e-93 312.0 COG1028@1|root,COG1028@2|Bacteria,1QXA0@1224|Proteobacteria,42UQH@68525|delta/epsilon subdivisions,2WQ5R@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 CMS1_k127_937761_14 861299.J421_0392 1.745e-65 239.0 COG1301@1|root,COG1301@2|Bacteria,1ZTDM@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF CMS1_k127_937761_30 1128421.JAGA01000002_gene1372 5.381e-07 63.0 COG3568@1|root,COG3568@2|Bacteria 2|Bacteria N Endonuclease Exonuclease Phosphatase - - - - - - - - - - - - Exo_endo_phos CMS1_k127_937761_18 522306.CAP2UW1_0011 4.115e-46 170.0 2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 CMS1_k127_937761_0 485913.Krac_3042 1.91e-252 794.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 CMS1_k127_937761_3 338966.Ppro_3258 2.609e-137 462.0 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,42MXP@68525|delta/epsilon subdivisions,2WMI1@28221|Deltaproteobacteria,43S3A@69541|Desulfuromonadales 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel CMS1_k127_937761_27 1123073.KB899242_gene1301 4.424e-15 90.0 298RU@1|root,3059D@2|Bacteria,1QRA7@1224|Proteobacteria,1TDHB@1236|Gammaproteobacteria,1XAQM@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - CMS1_k127_944600_7 1379270.AUXF01000003_gene3844 2.029e-21 102.0 COG0810@1|root,COG0810@2|Bacteria,1ZSVC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C CMS1_k127_944600_1 379066.GAU_2012 6.177e-101 346.0 COG5002@1|root,COG5002@2|Bacteria,1ZTF2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA CMS1_k127_944600_3 379066.GAU_2013 2.208e-87 300.0 COG0745@1|root,COG0745@2|Bacteria,1ZT8B@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C CMS1_k127_944600_0 861299.J421_3622 3.587e-119 402.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1ZTDZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PAS domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 CMS1_k127_944600_6 1192034.CAP_9027 1.826e-36 161.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,43AER@68525|delta/epsilon subdivisions,2X5UG@28221|Deltaproteobacteria,2YUH1@29|Myxococcales 28221|Deltaproteobacteria M NHL repeat - - - - - - - - - - - - CarboxypepD_reg,NHL,RHS_repeat CMS1_k127_944600_5 518766.Rmar_0355 5.416e-39 168.0 COG1629@1|root,COG4771@2|Bacteria,4NTQD@976|Bacteroidetes 976|Bacteroidetes P TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS1_k127_944600_2 1382304.JNIL01000001_gene3207 5.187e-92 312.0 COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,2781X@186823|Alicyclobacillaceae 91061|Bacilli P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodA - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N CMS1_k127_944600_4 1379270.AUXF01000005_gene495 7.604e-51 189.0 COG0664@1|root,COG0664@2|Bacteria,1ZTHA@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, cAMP Regulatory protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding CMS1_k127_947719_0 1278073.MYSTI_01056 4.098e-24 110.0 COG0697@1|root,COG0697@2|Bacteria,1MXX1@1224|Proteobacteria,42UPB@68525|delta/epsilon subdivisions,2WS1K@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS1_k127_947719_1 382464.ABSI01000013_gene1532 1.529e-19 103.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,BTAD,NACHT,NB-ARC,WD40 CMS1_k127_951026_4 861299.J421_0468 2.314e-101 366.0 COG0515@1|root,COG0515@2|Bacteria,1ZUHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_951026_11 42256.RradSPS_2795 8.918e-09 61.0 2EQM1@1|root,33I6Z@2|Bacteria,2GXMH@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 CMS1_k127_951026_9 395494.Galf_2868 2.506e-10 64.0 COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1MVWV@1224|Proteobacteria,2VN25@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfate transporter antisigma-factor antagonist STAS - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp,cNMP_binding CMS1_k127_951026_3 861299.J421_1760 7.659e-140 482.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS1_k127_951026_6 383372.Rcas_0264 1.68e-79 286.0 COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia 32061|Chloroflexia DZ PFAM regulator of chromosome condensation, RCC1 - - - - - - - - - - - - - CMS1_k127_951026_8 31964.CMS2961 2.322e-13 80.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS1_k127_951026_10 861299.J421_4379 6.901e-09 66.0 COG3595@1|root,COG3595@2|Bacteria,1ZTQ0@142182|Gemmatimonadetes 2|Bacteria - - - - - - - - - - - - - - DUF4097,PA14 CMS1_k127_951026_7 861299.J421_6034 4.18e-54 218.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS1_k127_951026_5 861299.J421_5836 1.65e-92 340.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS1_k127_951026_0 1506583.JQJY01000004_gene2830 1.318e-242 790.0 28IXK@1|root,2Z8VG@2|Bacteria,4NHBH@976|Bacteroidetes,1I0N4@117743|Flavobacteriia,2NUNB@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_951026_1 616991.JPOO01000003_gene151 1.241e-239 780.0 COG0457@1|root,COG0457@2|Bacteria,4NIBU@976|Bacteroidetes,1HZ35@117743|Flavobacteriia,23I14@178469|Arenibacter 976|Bacteroidetes S Domain of unknown function (DUF5107) - - - - - - - - - - - - DUF5107,TPR_16,TPR_8 CMS1_k127_951026_2 522306.CAP2UW1_2094 2.829e-208 670.0 COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1MVWV@1224|Proteobacteria,2VN25@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfate transporter antisigma-factor antagonist STAS - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp,cNMP_binding CMS1_k127_951026_12 483219.LILAB_30335 0.0001447 52.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - - - - - - - - - - OmpA,PKD CMS1_k127_958805_2 1379270.AUXF01000003_gene3536 8.39e-91 304.0 COG0281@1|root,COG0281@2|Bacteria,1ZUM5@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Malic enzyme, NAD binding domain - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic CMS1_k127_958805_0 378806.STAUR_5205 6.963e-296 920.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria,2YXXC@29|Myxococcales 28221|Deltaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS1_k127_958805_1 1379270.AUXF01000001_gene2280 6.568e-145 478.0 COG4447@1|root,COG4447@2|Bacteria,1ZSRH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 CMS1_k127_959913_8 485913.Krac_10956 7.308e-06 50.0 COG0533@1|root,COG0533@2|Bacteria,2G5V0@200795|Chloroflexi 200795|Chloroflexi J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 CMS1_k127_959913_5 379066.GAU_0618 5.707e-59 217.0 COG0682@1|root,COG0682@2|Bacteria,1ZSYY@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT CMS1_k127_959913_9 1150474.JQJI01000011_gene64 3.487e-05 52.0 COG0737@1|root,COG1520@1|root,COG0737@2|Bacteria,COG1520@2|Bacteria,2GCVR@200918|Thermotogae 200918|Thermotogae F PFAM PQQ enzyme repeat - - - - - - - - - - - - PQQ_3 CMS1_k127_959913_4 1502852.FG94_03263 1.308e-67 262.0 COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,2WF1G@28216|Betaproteobacteria,478XZ@75682|Oxalobacteraceae 28216|Betaproteobacteria P Iron permease FTR1 family efeU - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - Cytochrome_CBB3,FTR1 CMS1_k127_959913_3 1449080.JQMV01000003_gene1071 3.223e-76 277.0 COG0351@1|root,COG0351@2|Bacteria,1WIN0@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin CMS1_k127_959913_0 448385.sce3739 5.352e-199 644.0 COG1196@1|root,COG1196@2|Bacteria,1R3XQ@1224|Proteobacteria,42YF5@68525|delta/epsilon subdivisions,2WUDV@28221|Deltaproteobacteria,2YUHS@29|Myxococcales 28221|Deltaproteobacteria D 5' nucleotidase family surE2 - - - - - - - - - - - 5_nucleotid CMS1_k127_959913_6 1049564.TevJSym_ad00820 1.78e-40 156.0 COG2062@1|root,COG2062@2|Bacteria,1PKQU@1224|Proteobacteria,1TKA9@1236|Gammaproteobacteria,1J754@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 CMS1_k127_959913_2 861299.J421_3996 4.054e-111 379.0 COG2954@1|root,COG5607@1|root,COG2954@2|Bacteria,COG5607@2|Bacteria,1ZTYF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S CYTH - - - - - - - - - - - - CHAD CMS1_k127_959913_1 1232410.KI421421_gene3311 3.637e-114 394.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria,43UE3@69541|Desulfuromonadales 28221|Deltaproteobacteria FP metal-dependent phosphohydrolase, HD sub domain gppA-2 - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA CMS1_k127_959913_7 172088.AUGA01000019_gene2020 8.856e-30 124.0 COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria,3JUHX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B CMS1_k127_984644_1 67315.JOBD01000019_gene7598 0.0001063 55.0 COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria 201174|Actinobacteria O Peptidase s1 and s6 chymotrypsin hap sprI - - ko:K08372 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Trypsin_2 CMS1_k127_984644_2 93220.LV28_01010 0.0003221 53.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,1JZSU@119060|Burkholderiaceae 28216|Betaproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 CMS1_k127_984644_0 1237149.C900_03285 3.818e-34 138.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS1_k127_990866_2 314285.KT71_16676 3.71e-31 125.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1J9BX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS1_k127_990866_3 1034769.KB910518_gene3430 1.271e-25 118.0 COG0596@1|root,COG0596@2|Bacteria,1VEDI@1239|Firmicutes,4HQQ2@91061|Bacilli,26VR3@186822|Paenibacillaceae 91061|Bacilli S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 CMS1_k127_990866_1 1121875.KB907550_gene624 1.93e-99 341.0 COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,1HYQF@117743|Flavobacteriia 976|Bacteroidetes V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase,DUF3471 CMS1_k127_990866_0 290317.Cpha266_0257 6.993e-108 361.0 COG4974@1|root,COG4974@2|Bacteria,1FESB@1090|Chlorobi 1090|Chlorobi L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase ## 3795 queries scanned ## Total time (seconds): 53.72123646736145 ## Rate: 70.64 q/s