## Fri Nov 8 05:20:52 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS1_bin.81.fa -m mmseqs --itype genome -o CMS1_bin.81 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS1_bin.81 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs CMS1_k127_1005112_1 1131266.ARWQ01000024_gene142 7.708e-153 490.0 COG0428@1|root,arCOG00576@2157|Archaea,41S6R@651137|Thaumarchaeota 651137|Thaumarchaeota P divalent heavy-metal cations transporter - - - - - - - - - - - - - CMS1_k127_1005112_0 1229909.NSED_01585 1.635e-190 598.0 COG2132@1|root,arCOG03914@2157|Archaea,41S77@651137|Thaumarchaeota 651137|Thaumarchaeota Q PFAM Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 CMS1_k127_1005112_2 436308.Nmar_0327 1.427e-34 138.0 arCOG08779@1|root,arCOG08779@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1005112_3 1229909.NSED_01575 1.89e-28 117.0 arCOG08780@1|root,arCOG08780@2157|Archaea,41T84@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1051345_5 1229909.NSED_03275 4.592e-20 94.0 arCOG10531@1|root,arCOG10531@2157|Archaea,41T4F@651137|Thaumarchaeota 651137|Thaumarchaeota S zinc finger - - - - - - - - - - - - - CMS1_k127_1051345_4 436308.Nmar_0429 6.071e-25 108.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1051345_8 1229909.NSED_06250 1.132e-09 60.0 arCOG10955@1|root,arCOG10955@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1051345_1 1229909.NSED_06890 9.006e-50 181.0 COG4088@1|root,arCOG01041@2157|Archaea 2157|Archaea F PFAM Chromatin associated protein KTI12 pstK - 2.7.1.164,2.7.1.25 ko:K00860,ko:K10837 ko00230,ko00450,ko00920,ko00970,ko01100,ko01120,map00230,map00450,map00920,map00970,map01100,map01120 M00176 R00509,R04928,R08223 RC00002,RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - AAA_33,KTI12 CMS1_k127_1051345_2 374847.Kcr_0043 7.914e-46 177.0 COG0611@1|root,arCOG00638@2157|Archaea 2157|Archaea H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006725,GO:0006732,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS1_k127_1051345_0 1229909.NSED_07955 6.81e-210 661.0 COG1109@1|root,arCOG00767@2157|Archaea,41SC1@651137|Thaumarchaeota 651137|Thaumarchaeota G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - - - - - - - - - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS1_k127_1051345_7 1131266.ARWQ01000001_gene1078 2.711e-16 79.0 arCOG10410@1|root,arCOG10410@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1051345_9 1229909.NSED_07880 3.114e-09 61.0 arCOG11531@1|root,arCOG11531@2157|Archaea,41TAQ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1051345_3 436308.Nmar_1446 7.102e-45 164.0 COG3432@1|root,arCOG01055@2157|Archaea,41SST@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 CMS1_k127_1051345_6 1229909.NSED_07870 3.916e-19 87.0 arCOG08730@1|root,arCOG08730@2157|Archaea,41SNH@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1064792_3 436308.Nmar_1032 2.777e-32 126.0 COG1996@1|root,arCOG04341@2157|Archaea,41SWH@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - - 2.7.7.6 ko:K03059 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - - CMS1_k127_1064792_4 1229909.NSED_06075 2.68e-24 103.0 arCOG10406@1|root,arCOG10406@2157|Archaea,41SVU@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger, C2H2 type - - - - - - - - - - - - zf-C2H2 CMS1_k127_1064792_0 1229909.NSED_06070 1.579e-79 266.0 arCOG08678@1|root,arCOG08678@2157|Archaea,41SR1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1064792_2 1131266.ARWQ01000001_gene1295 3.123e-50 187.0 COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - CMS1_k127_1064792_1 1229909.NSED_06065 7.74e-76 258.0 COG1611@1|root,arCOG02431@2157|Archaea,41SMW@651137|Thaumarchaeota 651137|Thaumarchaeota S Rossmann fold nucleotide-binding protein - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox CMS1_k127_1067564_0 436308.Nmar_1004 2.216e-148 472.0 COG0405@1|root,arCOG04053@2157|Archaea 2157|Archaea E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS1_k127_1067564_1 436308.Nmar_1003 6.079e-120 389.0 COG3741@1|root,arCOG08266@2157|Archaea 2157|Archaea E N-formylglutamate amidohydrolase - - 3.5.3.8 ko:K01479 ko00340,ko01100,map00340,map01100 M00045 R02285 RC00221,RC00681 ko00000,ko00001,ko00002,ko01000 - - - FGase CMS1_k127_1067564_2 1229909.NSED_07345 2.332e-23 98.0 arCOG03272@1|root,arCOG03272@2157|Archaea 2157|Archaea - - - - 2.7.7.6 ko:K00960 - - - - ko00000,ko01000 - - - - CMS1_k127_1067564_3 1229909.NSED_01175 2.443e-05 47.0 COG1581@1|root,arCOG01753@2157|Archaea,41SQ4@651137|Thaumarchaeota 651137|Thaumarchaeota K Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes - - - ko:K03622 - - - - ko00000 - - - Alba CMS1_k127_1136136_2 1229909.NSED_09005 4.447e-225 699.0 COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota 651137|Thaumarchaeota F Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit atpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn CMS1_k127_1136136_5 1229909.NSED_09010 3.497e-79 269.0 COG1390@1|root,arCOG00869@2157|Archaea,41T4W@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane atpE - - ko:K02121 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_E CMS1_k127_1136136_0 1229909.NSED_09015 0.0 1152.0 COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I CMS1_k127_1136136_3 1229909.NSED_09030 1.251e-125 407.0 COG2897@1|root,arCOG02019@2157|Archaea,41SXR@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese CMS1_k127_1136136_1 436308.Nmar_1698 0.0 1006.0 COG0004@1|root,arCOG04397@2157|Archaea,41SY0@651137|Thaumarchaeota 651137|Thaumarchaeota P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp CMS1_k127_1136136_4 1229909.NSED_09045 3.12e-103 340.0 arCOG08770@1|root,arCOG08770@2157|Archaea,41T2S@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1136136_6 436308.Nmar_1700 7.431e-40 149.0 COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (C/AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 CMS1_k127_1186156_2 604354.TSIB_0244 1.251e-07 53.0 COG1756@1|root,arCOG04122@2157|Archaea,2XX9G@28890|Euryarchaeota,243H9@183968|Thermococci 183968|Thermococci J Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA nep1 GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.260 ko:K14568 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009 - - - EMG1 CMS1_k127_1186156_0 1229909.NSED_08865 1.512e-162 519.0 arCOG08791@1|root,arCOG08791@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1186156_1 436308.Nmar_1627 1.027e-124 400.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN CMS1_k127_1228550_1 1229909.NSED_06960 5.144e-24 104.0 arCOG08716@1|root,arCOG08716@2157|Archaea 1229909.NSED_06960|- - - - - - - - - - - - - - - - CMS1_k127_1228550_0 1229909.NSED_06965 2.19e-123 404.0 arCOG08777@1|root,arCOG10350@1|root,arCOG08777@2157|Archaea,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - CMS1_k127_1228805_1 436308.Nmar_1761 1.869e-63 221.0 COG1878@1|root,arCOG02462@2157|Archaea,41SK8@651137|Thaumarchaeota 651137|Thaumarchaeota E Putative cyclase - - - - - - - - - - - - Cyclase CMS1_k127_1228805_2 436308.Nmar_1762 2.457e-37 141.0 COG1522@1|root,arCOG01117@2157|Archaea,41T58@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg CMS1_k127_1228805_0 1229909.NSED_09410 5.045e-189 596.0 COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 CMS1_k127_1229618_0 1229909.NSED_07100 0.0 1050.0 COG0294@1|root,COG1410@1|root,arCOG02029@2157|Archaea,arCOG02817@2157|Archaea,41SXT@651137|Thaumarchaeota 651137|Thaumarchaeota E Methionine synthase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind CMS1_k127_1229618_1 436308.Nmar_1268 2.622e-61 211.0 COG0646@1|root,arCOG08715@2157|Archaea,41SWZ@651137|Thaumarchaeota 651137|Thaumarchaeota E homocysteine S-methyltransferase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - S-methyl_trans CMS1_k127_123505_1 436308.Nmar_0367 9.743e-97 318.0 COG0495@1|root,arCOG00809@2157|Archaea,41SES@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1 CMS1_k127_123505_0 1229909.NSED_01805 1.43e-322 998.0 COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS1_k127_1248526_0 1229909.NSED_04760 4.191e-66 231.0 COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional - - - - - - - - - - - - TrmB CMS1_k127_1267503_1 1229909.NSED_00570 8.513e-94 308.0 COG0136@1|root,arCOG00494@2157|Archaea,41SFD@651137|Thaumarchaeota 651137|Thaumarchaeota E aspartate-semialdehyde dehydrogenase - - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC CMS1_k127_1267503_2 436308.Nmar_1587 2.94e-66 228.0 COG1522@1|root,arCOG01580@2157|Archaea,41SKI@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - ko:K03718 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24 CMS1_k127_1267503_0 1229909.NSED_00560 5.024e-177 557.0 COG0109@1|root,arCOG00479@2157|Archaea,41SFH@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA CMS1_k127_1267503_3 436308.Nmar_1589 2.333e-20 91.0 arCOG10591@1|root,arCOG10591@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_126763_1 1229909.NSED_05605 3.245e-52 190.0 COG2430@1|root,arCOG01766@2157|Archaea,41T8S@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF432) - - - ko:K09149 - - - - ko00000 - - - DUF432 CMS1_k127_126763_0 436308.Nmar_0971 8.317e-116 379.0 COG0668@1|root,arCOG01568@2157|Archaea,41T3B@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel CMS1_k127_1271080_0 1229909.NSED_07730 5.233e-162 510.0 COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6A - 5.99.1.3 ko:K03166 - - - - ko00000,ko01000,ko03032 - - - TP6A_N CMS1_k127_1271080_1 436308.Nmar_1406 3.354e-81 273.0 COG0071@1|root,arCOG01833@2157|Archaea 2157|Archaea O Belongs to the small heat shock protein (HSP20) family - - - - - - - - - - - - - CMS1_k127_1271080_2 436308.Nmar_1360 5.717e-28 119.0 COG2968@1|root,arCOG04715@2157|Archaea,41T6R@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF541) - - - ko:K09807 - - - - ko00000 - - - SIMPL CMS1_k127_1280915_2 1459636.NTE_00004 2.413e-44 171.0 COG0468@1|root,arCOG00415@2157|Archaea 2157|Archaea L Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules - - - ko:K04483 - - - - ko00000,ko03400 - - - HHH_5,Rad51 CMS1_k127_1280915_1 1229909.NSED_03600 1.16e-75 258.0 COG2016@1|root,arCOG00985@2157|Archaea,41SSC@651137|Thaumarchaeota 651137|Thaumarchaeota J PUA domain - - - ko:K07575 - - - - ko00000 - - - PUA CMS1_k127_1280915_0 1229909.NSED_03605 5.057e-114 369.0 COG0460@1|root,arCOG01351@2157|Archaea,41SAC@651137|Thaumarchaeota 651137|Thaumarchaeota E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - Homoserine_dh,NAD_binding_3 CMS1_k127_12883_2 436308.Nmar_0843 2.985e-14 72.0 COG1208@1|root,arCOG00663@2157|Archaea,41SIU@651137|Thaumarchaeota 651137|Thaumarchaeota M Nucleotidyl transferase - - - - - - - - - - - - NTP_transferase CMS1_k127_12883_0 436308.Nmar_0842 2.203e-151 484.0 COG2141@1|root,arCOG02410@2157|Archaea,41SC0@651137|Thaumarchaeota 651137|Thaumarchaeota C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase CMS1_k127_12883_1 1229909.NSED_04630 3.971e-107 353.0 COG0183@1|root,arCOG01278@2157|Archaea,41SB7@651137|Thaumarchaeota 651137|Thaumarchaeota I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_1303330_0 436308.Nmar_0348 0.0 1242.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 CMS1_k127_135029_3 1229909.NSED_05515 1.906e-80 269.0 COG2185@1|root,arCOG01710@2157|Archaea,41SJN@651137|Thaumarchaeota 651137|Thaumarchaeota I B12 binding domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding CMS1_k127_135029_0 436308.Nmar_0959 3.27e-194 608.0 COG0059@1|root,arCOG04465@2157|Archaea,41S65@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN CMS1_k127_135029_2 436308.Nmar_0960 4.664e-84 281.0 COG1056@1|root,arCOG00972@2157|Archaea,41T2U@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.1 ko:K00952 ko00760,ko01100,map00760,map01100 - R00137,R03005 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like CMS1_k127_135029_1 1229909.NSED_05535 7.568e-159 504.0 COG3276@1|root,arCOG01564@2157|Archaea,41SCR@651137|Thaumarchaeota 651137|Thaumarchaeota J elongation factor Tu - - - - - - - - - - - - GTP_EFTU_D2 CMS1_k127_1432058_1 436308.Nmar_1429 6.758e-95 317.0 COG1617@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG02197@2157|Archaea,41SSW@651137|Thaumarchaeota 651137|Thaumarchaeota H Kinase binding protein CGI-121 - - - - - - - - - - - - CGI-121,ThiS CMS1_k127_1432058_4 1131266.ARWQ01000018_gene768 1.91e-46 173.0 COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota 651137|Thaumarchaeota S THUMP domain - - - ko:K06963 - - - - ko00000,ko03016 - - - THUMP CMS1_k127_1432058_2 436308.Nmar_1427 4.081e-75 257.0 COG0009@1|root,arCOG01952@2157|Archaea,41SPF@651137|Thaumarchaeota 651137|Thaumarchaeota J Sua5 YciO YrdC YwlC family - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC CMS1_k127_1432058_3 436308.Nmar_1426 7.188e-47 169.0 COG3432@1|root,arCOG01055@2157|Archaea,41SUJ@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 CMS1_k127_1432058_0 436308.Nmar_1425 8.084e-115 372.0 arCOG08771@1|root,arCOG08771@2157|Archaea,41SNZ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1453609_2 436308.Nmar_0505 1.943e-34 133.0 COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota 651137|Thaumarchaeota L COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins - - - ko:K07466 ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460 M00288 - - ko00000,ko00001,ko00002,ko03000,ko03032,ko03400 - - - tRNA_anti-codon CMS1_k127_1453609_0 436308.Nmar_0506 2.873e-106 347.0 arCOG03119@1|root,arCOG03119@2157|Archaea,41T0Y@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM SNARE associated Golgi protein - - - - - - - - - - - - - CMS1_k127_1453609_1 436308.Nmar_0507 1.665e-91 304.0 COG1418@1|root,arCOG01860@2157|Archaea,41T2N@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06950 - - - - ko00000 - - - HD CMS1_k127_1497255_3 1229909.NSED_03215 4.484e-72 243.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon CMS1_k127_1497255_2 1229909.NSED_03220 2.564e-94 313.0 COG1920@1|root,arCOG04472@2157|Archaea,41SPV@651137|Thaumarchaeota 651137|Thaumarchaeota H Guanylyl transferase CofC like - - 2.7.7.68 ko:K14941 ko00680,ko01120,map00680,map01120 M00378 R09397 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CofC CMS1_k127_1497255_0 1229909.NSED_03225 7.403e-190 595.0 COG0391@1|root,arCOG04395@2157|Archaea,41SCH@651137|Thaumarchaeota 651137|Thaumarchaeota H Uncharacterised protein family UPF0052 - - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 CMS1_k127_1497255_1 1229909.NSED_03230 2.13e-106 349.0 arCOG08742@1|root,arCOG08742@2157|Archaea,41SS8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_150484_4 1229909.NSED_04460 5.641e-14 71.0 COG0092@1|root,arCOG04097@2157|Archaea,41SIM@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds the lower part of the 30S subunit head rps3 - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C CMS1_k127_150484_1 436308.Nmar_0805 7.295e-85 283.0 COG0091@1|root,arCOG04098@2157|Archaea,41SJ4@651137|Thaumarchaeota 651137|Thaumarchaeota J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rpl22 - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 CMS1_k127_150484_2 1229909.NSED_04470 1.207e-66 228.0 COG0185@1|root,arCOG04099@2157|Archaea,41SMH@651137|Thaumarchaeota 651137|Thaumarchaeota J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rps19p - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 CMS1_k127_150484_3 436308.Nmar_0807 1.111e-43 160.0 COG0089@1|root,arCOG04072@2157|Archaea,41SS4@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome rpl23 - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 CMS1_k127_150484_0 436308.Nmar_0808 8.469e-128 413.0 COG0469@1|root,arCOG04071@2157|Archaea,41SHB@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein L4 - - - ko:K02930 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 CMS1_k127_1526303_5 1229909.NSED_00260 4.102e-25 106.0 arCOG08724@1|root,arCOG08724@2157|Archaea,41TA8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1526303_1 436308.Nmar_0111 1.455e-72 246.0 COG0432@1|root,arCOG04214@2157|Archaea,41T31@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 CMS1_k127_1526303_2 436308.Nmar_0110 3.602e-69 237.0 arCOG08723@1|root,arCOG08723@2157|Archaea,41SPX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1526303_0 436308.Nmar_0109 1.898e-175 555.0 COG1537@1|root,arCOG01741@2157|Archaea,41S6V@651137|Thaumarchaeota 651137|Thaumarchaeota J May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity pelA - - ko:K06965 ko03015,map03015 - - - ko00000,ko00001 - - - eRF1_1,eRF1_3 CMS1_k127_1526303_3 436308.Nmar_0108 5.108e-43 160.0 COG1324@1|root,arCOG04231@2157|Archaea,41SR4@651137|Thaumarchaeota 651137|Thaumarchaeota P PFAM CutA1 divalent ion tolerance protein - - - ko:K03926 - - - - ko00000 - - - CutA1 CMS1_k127_1526303_4 436308.Nmar_0107 9.169e-39 146.0 COG0750@1|root,arCOG04064@2157|Archaea,41SW5@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - PDZ_2,Peptidase_M50 CMS1_k127_1573139_2 436308.Nmar_1740 5.286e-43 157.0 COG0652@1|root,arCOG04767@2157|Archaea,41T32@651137|Thaumarchaeota 651137|Thaumarchaeota O peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase CMS1_k127_1573139_0 1229909.NSED_09265 3.715e-72 254.0 arCOG08768@1|root,arCOG08768@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1573139_4 436308.Nmar_1742 2.685e-28 113.0 arCOG07262@1|root,arCOG07262@2157|Archaea,41T8B@651137|Thaumarchaeota 651137|Thaumarchaeota S IMP dehydrogenase activity - - - - - - - - - - - - - CMS1_k127_1573139_3 1229909.NSED_09275 1.396e-28 115.0 arCOG11612@1|root,arCOG11612@2157|Archaea,41T8D@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1573139_1 436308.Nmar_1743 1.885e-54 194.0 arCOG10601@1|root,arCOG10601@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_157361_1 1229909.NSED_06945 4.357e-77 259.0 COG0379@1|root,arCOG04459@2157|Archaea,41S6Y@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA CMS1_k127_157361_0 1229909.NSED_06950 1.195e-144 461.0 COG1712@1|root,arCOG00254@2157|Archaea,41SGA@651137|Thaumarchaeota 651137|Thaumarchaeota H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate nadX - 1.4.1.21 ko:K06989 ko00760,ko01100,map00760,map01100 - R07407,R07410 RC02566 ko00000,ko00001,ko01000 - - - DUF108,NAD_binding_3 CMS1_k127_157361_2 1229909.NSED_06960 2.139e-72 247.0 arCOG08716@1|root,arCOG08716@2157|Archaea 1229909.NSED_06960|- - - - - - - - - - - - - - - - CMS1_k127_1597920_2 1229909.NSED_07785 1.346e-132 425.0 COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota 651137|Thaumarchaeota F Orotidine 5'-phosphate decarboxylase / HUMPS family - - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase CMS1_k127_1597920_3 444157.Tneu_1020 1.16e-31 129.0 COG0494@1|root,arCOG01078@2157|Archaea 2157|Archaea L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX CMS1_k127_1597920_1 436308.Nmar_1416 3.017e-143 456.0 COG0020@1|root,arCOG01532@2157|Archaea,41S8J@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids uppS - 2.5.1.89 ko:K15888 ko00900,map00900 - R09730 RC00279,RC02839 ko00000,ko00001,ko01000 - - - Prenyltransf CMS1_k127_1597920_0 1229909.NSED_07770 7.022e-196 615.0 COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF373) - - - ko:K08975 - - - - ko00000 - - - DUF373 CMS1_k127_1597920_4 436308.Nmar_1414 3.259e-23 101.0 arCOG08774@1|root,arCOG08774@2157|Archaea,41T7U@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1620667_3 436308.Nmar_1232 6.689e-44 160.0 arCOG08718@1|root,arCOG08718@2157|Archaea,41T2G@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - ko:K07043 - - - - ko00000 - - - - CMS1_k127_1620667_1 436308.Nmar_1233 1.146e-64 225.0 COG1909@1|root,arCOG04076@2157|Archaea,41SNQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0218 family - - - ko:K09735 - - - - ko00000 - - - DUF359 CMS1_k127_1620667_0 436308.Nmar_1234 1.112e-211 662.0 COG0489@1|root,arCOG01846@1|root,arCOG00585@2157|Archaea,arCOG01846@2157|Archaea,41SF1@651137|Thaumarchaeota 651137|Thaumarchaeota D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA CMS1_k127_1620667_2 1229909.NSED_06925 5.891e-44 163.0 COG1095@1|root,arCOG00675@2157|Archaea,41SGF@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-directed RNA polymerase - - 2.7.7.6 ko:K03049 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - S1,SHS2_Rpb7-N CMS1_k127_1643071_0 1229909.NSED_03915 8.649e-111 368.0 arCOG08742@1|root,arCOG08742@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1643071_1 1229909.NSED_03910 1.079e-78 267.0 COG0640@1|root,arCOG01686@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_20,HTH_5 CMS1_k127_1661740_0 1229909.NSED_09165 3.261e-155 494.0 COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein CMS1_k127_1661740_3 1459636.NTE_02601 7.826e-95 318.0 COG0413@1|root,arCOG00584@2157|Archaea,41SZX@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf CMS1_k127_1661740_2 436308.Nmar_1719 1.804e-108 356.0 COG1701@1|root,arCOG04262@2157|Archaea,41SXP@651137|Thaumarchaeota 651137|Thaumarchaeota S Pfam:DUF137 - - 6.3.2.36 ko:K09722 ko00410,ko00770,ko01100,map00410,map00770,map01100 - R09379 RC00096,RC00141 ko00000,ko00001,ko01000 - - - PPS_PS CMS1_k127_1661740_1 436308.Nmar_1718 9.088e-114 372.0 COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota 651137|Thaumarchaeota S kinase, sugar kinase superfamily - - 2.7.1.169 ko:K06982 ko00770,ko01100,map00770,map01100 - R09378 RC00002,RC00017 ko00000,ko00001,ko01000 - - - GHMP_kinases_N CMS1_k127_1677199_2 1229909.NSED_04150 1.015e-15 78.0 arCOG10540@1|root,arCOG10540@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1677199_0 436308.Nmar_0690 2.277e-149 477.0 COG2519@1|root,arCOG00978@2157|Archaea,41SEF@651137|Thaumarchaeota 651137|Thaumarchaeota Q tRNA methyltransferase complex GCD14 subunit - - 2.1.1.219,2.1.1.220 ko:K07442 - - - - ko00000,ko01000,ko03016 - - - GCD14 CMS1_k127_1677199_1 436308.Nmar_0691 3.351e-119 387.0 COG0063@1|root,arCOG00018@2157|Archaea,41S8I@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136 ko:K17758 - - - - ko00000,ko01000 - - - Carb_kinase CMS1_k127_1686046_6 1229909.NSED_00070 2.581e-38 146.0 COG1287@1|root,arCOG02044@2157|Archaea,41SBI@651137|Thaumarchaeota 651137|Thaumarchaeota G Oligosaccharyl transferase STT3 subunit - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 CMS1_k127_1686046_0 436308.Nmar_0115 0.0 1146.0 COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota 651137|Thaumarchaeota S Radical SAM - - - ko:K06937 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM CMS1_k127_1686046_1 1229909.NSED_00270 5.053e-138 442.0 COG1378@1|root,arCOG02038@2157|Archaea,41SFR@651137|Thaumarchaeota 651137|Thaumarchaeota K Archaeal transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB CMS1_k127_1686046_4 1229909.NSED_00265 1.385e-83 278.0 COG1321@1|root,arCOG02100@2157|Archaea,41SIJ@651137|Thaumarchaeota 651137|Thaumarchaeota K Helix-turn-helix diphteria tox regulatory element - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress CMS1_k127_1686046_5 436308.Nmar_1712 9.449e-72 245.0 COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota 651137|Thaumarchaeota M extracellular matrix structural constituent - - - - - - - - - - - - - CMS1_k127_1686046_2 436308.Nmar_1712 6.041e-125 404.0 COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota 651137|Thaumarchaeota M extracellular matrix structural constituent - - - - - - - - - - - - - CMS1_k127_1686046_3 436308.Nmar_1713 2.65e-91 302.0 COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran CMS1_k127_1687231_3 436308.Nmar_0403 7.068e-76 258.0 COG2019@1|root,arCOG01039@2157|Archaea,41SK7@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the archaeal adenylate kinase family adkA - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AAA_17 CMS1_k127_1687231_1 1229909.NSED_08810 3.533e-95 315.0 COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota 651137|Thaumarchaeota U membrane - - - - - - - - - - - - DUF106 CMS1_k127_1687231_2 1229909.NSED_01960 1.893e-90 301.0 COG1102@1|root,arCOG01037@2157|Archaea,41SKS@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the cytidylate kinase family. Type 2 subfamily cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin2 CMS1_k127_1687231_0 1229909.NSED_01965 1.418e-190 598.0 COG0130@1|root,arCOG00987@2157|Archaea,41S8E@651137|Thaumarchaeota 651137|Thaumarchaeota J Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs truB - - ko:K11131 ko03008,map03008 M00425 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03032 - - - DKCLD,PUA,TruB_C_2,TruB_N CMS1_k127_1687231_4 436308.Nmar_0407 4.885e-56 199.0 arCOG07571@1|root,arCOG07571@2157|Archaea,41T4H@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1687231_5 1229909.NSED_04760 1.41e-12 72.0 COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional - - - - - - - - - - - - TrmB CMS1_k127_1694839_2 1229909.NSED_00080 3.725e-98 323.0 COG1093@1|root,arCOG04107@2157|Archaea,41SHY@651137|Thaumarchaeota 651137|Thaumarchaeota J Translation initiation factor 2, alpha subunit - - - ko:K03237 ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168 - - - ko00000,ko00001,ko03012 - - - EIF_2_alpha,S1 CMS1_k127_1694839_6 1229909.NSED_00075 2.205e-24 104.0 COG2260@1|root,arCOG00906@2157|Archaea,41SUI@651137|Thaumarchaeota 651137|Thaumarchaeota J more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA nop10 - - ko:K11130 ko03008,map03008 M00425 - - ko00000,ko00001,ko00002,ko03009,ko03032 - - - Nop10p CMS1_k127_1694839_3 1229909.NSED_00065 3.639e-64 222.0 COG1881@1|root,arCOG04702@2157|Archaea,41T4M@651137|Thaumarchaeota 651137|Thaumarchaeota S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP CMS1_k127_1694839_0 1229909.NSED_00055 5.644e-243 753.0 COG3276@1|root,arCOG01563@2157|Archaea,41S80@651137|Thaumarchaeota 651137|Thaumarchaeota J Initiation factor - - - ko:K03242 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,eIF2_C CMS1_k127_1694839_4 1229909.NSED_00050 2.447e-62 216.0 COG2125@1|root,arCOG01946@2157|Archaea,41SPC@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS6 family rps6e - - ko:K02991 ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S6e CMS1_k127_1694839_5 436308.Nmar_0070 7.398e-27 109.0 arCOG08820@1|root,arCOG08820@2157|Archaea,41SWF@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1694839_1 1229909.NSED_00040 1.154e-139 450.0 COG0457@1|root,arCOG03032@2157|Archaea,41T0V@651137|Thaumarchaeota 651137|Thaumarchaeota S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1 CMS1_k127_1694839_7 1229909.NSED_00035 2.882e-22 96.0 COG0518@1|root,arCOG00087@2157|Archaea,41SQR@651137|Thaumarchaeota 651137|Thaumarchaeota F glutamine amidotransferase - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase CMS1_k127_174668_1 436308.Nmar_0353 2.773e-74 250.0 COG0195@1|root,arCOG01760@2157|Archaea,41SJQ@651137|Thaumarchaeota 651137|Thaumarchaeota K Participates in transcription termination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_2 CMS1_k127_174668_2 1229909.NSED_01695 2.397e-47 171.0 COG1911@1|root,arCOG01752@2157|Archaea,41SW9@651137|Thaumarchaeota 651137|Thaumarchaeota J PFAM ribosomal protein L7Ae L30e S12e Gadd45 - - - ko:K02908 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L7Ae CMS1_k127_174668_0 1229909.NSED_01690 1.482e-130 433.0 COG0457@1|root,arCOG08643@1|root,arCOG03032@2157|Archaea,arCOG08643@2157|Archaea 2157|Archaea S peptidyl-tyrosine sulfation - - - - - - - - - - - - TPR_1,TPR_16,TPR_8 CMS1_k127_174668_3 436308.Nmar_0350 2.944e-21 94.0 arCOG08777@1|root,arCOG08777@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1757354_1 436308.Nmar_1633 2.527e-146 467.0 COG0388@1|root,arCOG00062@2157|Archaea,41SF8@651137|Thaumarchaeota 651137|Thaumarchaeota S Carbon-nitrogen hydrolase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase CMS1_k127_1757354_2 1131266.ARWQ01000009_gene926 4.308e-58 205.0 arCOG10412@1|root,arCOG10412@2157|Archaea,41SS9@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1757354_0 1229909.NSED_08890 1.714e-163 516.0 COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota 651137|Thaumarchaeota I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_1805904_3 436308.Nmar_1089 1.144e-30 124.0 arCOG08707@1|root,arCOG08707@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1805904_2 436308.Nmar_1090 3.979e-50 184.0 COG5491@1|root,arCOG00452@2157|Archaea 2157|Archaea N conserved protein implicated in secretion - - - - - - - - - - - - Snf7 CMS1_k127_1805904_0 436308.Nmar_1091 1.827e-191 603.0 COG1378@1|root,arCOG02037@2157|Archaea,41T17@651137|Thaumarchaeota 651137|Thaumarchaeota K Sugar-specific transcriptional regulator TrmB - - - - - - - - - - - - TrmB CMS1_k127_1805904_1 1229909.NSED_06360 2.293e-74 252.0 COG0251@1|root,arCOG01630@2157|Archaea,41T4N@651137|Thaumarchaeota 651137|Thaumarchaeota J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc CMS1_k127_182055_7 436308.Nmar_0341 5.403e-34 131.0 COG1104@1|root,arCOG00066@2157|Archaea,41SB1@651137|Thaumarchaeota 651137|Thaumarchaeota E Cysteine desulfurase - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 CMS1_k127_182055_4 436308.Nmar_0342 3.497e-72 252.0 arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3A@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_182055_1 436308.Nmar_0343 4.564e-101 336.0 arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T4R@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_182055_3 1229909.NSED_01655 1.788e-92 311.0 arCOG08643@1|root,arCOG08643@2157|Archaea,41T2H@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_182055_2 436308.Nmar_0345 9.977e-95 317.0 arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_182055_6 1229909.NSED_01665 1.28e-46 168.0 COG2012@1|root,arCOG04258@2157|Archaea,41SU8@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoH - 2.7.7.6 ko:K03053 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb5_C CMS1_k127_182055_0 1229909.NSED_01670 0.0 2155.0 COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - - 2.7.7.6 ko:K13798 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 CMS1_k127_182055_5 1229909.NSED_01675 3.135e-53 187.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 CMS1_k127_1826250_2 1229909.NSED_01710 1.194e-102 335.0 COG0049@1|root,arCOG04254@2157|Archaea,41S6U@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center rps7 - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 CMS1_k127_1826250_3 1229909.NSED_01715 4.779e-55 194.0 arCOG10523@1|root,arCOG10523@2157|Archaea,41SSZ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1826250_1 1229909.NSED_01720 5.636e-134 428.0 COG0727@1|root,arCOG02579@2157|Archaea,41SH8@651137|Thaumarchaeota 651137|Thaumarchaeota S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC CMS1_k127_1826250_0 1131266.ARWQ01000001_gene1155 1.223e-177 560.0 COG0644@1|root,arCOG00570@2157|Archaea,41SCG@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - Trp_halogenase CMS1_k127_1826250_4 1229909.NSED_08225 4.272e-21 107.0 arCOG08038@1|root,arCOG08733@1|root,arCOG08038@2157|Archaea,arCOG08733@2157|Archaea 2157|Archaea S protein secretion by the type IV secretion system - - - - - - - - - - - - - CMS1_k127_1853470_2 1229909.NSED_03450 1.217e-45 169.0 COG0039@1|root,arCOG00246@2157|Archaea,41S7Z@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the LDH MDH superfamily - - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N CMS1_k127_1853470_0 1229909.NSED_09470 5.824e-109 356.0 COG1814@1|root,arCOG01096@2157|Archaea,41T0M@651137|Thaumarchaeota 651137|Thaumarchaeota S VIT family - - - - - - - - - - - - VIT1 CMS1_k127_1853470_1 1229909.NSED_09465 2.82e-62 216.0 COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS CMS1_k127_1856938_0 1229909.NSED_03040 1.511e-178 561.0 COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f CMS1_k127_1856938_4 1229909.NSED_03035 7.383e-20 90.0 arCOG10985@1|root,arCOG10985@2157|Archaea,41T8V@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1856938_2 1229909.NSED_03030 7.032e-48 184.0 arCOG08034@1|root,arCOG08034@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1856938_1 1229909.NSED_03025 1.057e-57 203.0 COG3576@1|root,arCOG00518@2157|Archaea,41T47@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx CMS1_k127_1856938_3 1229909.NSED_03010 2.267e-27 111.0 arCOG08736@1|root,arCOG08736@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1893939_3 1229909.NSED_05295 7.04e-43 160.0 COG2064@1|root,arCOG01808@2157|Archaea 2157|Archaea NU Type II secretion system - - - ko:K07333 - - - - ko00000,ko02035,ko02044 - - - T2SSF CMS1_k127_1893939_1 1229909.NSED_05290 3.699e-137 441.0 COG2064@1|root,arCOG01808@2157|Archaea 2157|Archaea NU Type II secretion system - - - ko:K07333 - - - - ko00000,ko02035,ko02044 - - - T2SSF CMS1_k127_1893939_0 1229909.NSED_05285 7.553e-271 841.0 COG4962@1|root,arCOG01817@2157|Archaea,41T25@651137|Thaumarchaeota 651137|Thaumarchaeota N COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis - - - ko:K07332 - - - - ko00000,ko02035,ko02044 - - - T2SSE CMS1_k127_1893939_2 1229909.NSED_05280 2.777e-65 233.0 arCOG06883@1|root,arCOG06883@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - DUF2334,DZR CMS1_k127_189412_0 436308.Nmar_0822 5.082e-190 598.0 COG0161@1|root,arCOG00917@2157|Archaea,41S7K@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_189412_1 1229909.NSED_08925 3.898e-13 74.0 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1915821_6 436308.Nmar_1360 7.049e-25 106.0 COG2968@1|root,arCOG04715@2157|Archaea,41T6R@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF541) - - - ko:K09807 - - - - ko00000 - - - SIMPL CMS1_k127_1915821_7 1229909.NSED_07615 2.364e-16 81.0 arCOG08701@1|root,arCOG08701@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_1915821_5 436308.Nmar_1404 8.34e-44 162.0 arCOG08702@1|root,arCOG08702@2157|Archaea,41ST2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1915821_3 1229909.NSED_07605 1.799e-69 237.0 arCOG08703@1|root,arCOG08703@2157|Archaea,41SS0@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1915821_4 1229909.NSED_07600 1.274e-44 163.0 arCOG08704@1|root,arCOG08704@2157|Archaea,41STG@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_1915821_0 436308.Nmar_1401 2.012e-149 475.0 COG0005@1|root,arCOG01327@2157|Archaea,41SDR@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 CMS1_k127_1915821_2 1229909.NSED_07590 4.28e-93 308.0 COG0503@1|root,arCOG00030@2157|Archaea,41SMR@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran CMS1_k127_1915821_1 1229909.NSED_07585 2.714e-100 333.0 arCOG08705@1|root,arCOG08705@2157|Archaea,41SXV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_195931_4 1229909.NSED_05805 1.846e-26 110.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH CMS1_k127_195931_0 1144275.COCOR_00573 2.334e-102 349.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2WKPM@28221|Deltaproteobacteria,2YTUX@29|Myxococcales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_195931_1 436308.Nmar_1624 1.321e-83 278.0 COG2238@1|root,arCOG01344@2157|Archaea,41SK1@651137|Thaumarchaeota 651137|Thaumarchaeota J May be involved in maturation of the 30S ribosomal subunit rps19e - - ko:K02966 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19e CMS1_k127_195931_3 1229909.NSED_08785 6.342e-29 118.0 COG2118@1|root,arCOG04179@2157|Archaea,41SR0@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the PDCD5 family - - - ko:K06875 - - - - ko00000 - - - dsDNA_bind CMS1_k127_195931_2 1229909.NSED_08780 1.248e-56 198.0 COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N CMS1_k127_1959897_1 1408813.AYMG01000028_gene2376 3.947e-41 162.0 COG3325@1|root,COG3325@2|Bacteria,4NGAZ@976|Bacteroidetes,1IV7G@117747|Sphingobacteriia 976|Bacteroidetes G Glyco_18 - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Glyco_hydro_18 CMS1_k127_1959897_0 436308.Nmar_0475 4.174e-179 564.0 COG1131@1|root,arCOG00194@2157|Archaea,41TB9@651137|Thaumarchaeota 651137|Thaumarchaeota V Domain of unknown function (DUF4162) - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 CMS1_k127_1959897_2 1229909.NSED_02400 2.503e-40 150.0 COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane CMS1_k127_2006116_3 436308.Nmar_0666 2.048e-16 78.0 COG0560@1|root,arCOG01158@2157|Archaea,41SHX@651137|Thaumarchaeota 651137|Thaumarchaeota E phosphoserine phosphatase - - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD CMS1_k127_2006116_1 1229909.NSED_03390 1.137e-100 332.0 COG1478@1|root,arCOG02714@2157|Archaea,41T27@651137|Thaumarchaeota 651137|Thaumarchaeota H F420-0:Gamma-glutamyl ligase - - 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase CMS1_k127_2006116_2 1229909.NSED_03505 3.435e-40 149.0 COG0425@1|root,arCOG02062@2157|Archaea,41SU5@651137|Thaumarchaeota 651137|Thaumarchaeota O redox protein, regulator of disulfide bond formation - - - - - - - - - - - - TusA CMS1_k127_2006116_0 436308.Nmar_0670 1.112e-195 612.0 COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota 651137|Thaumarchaeota E Cysteine synthase - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_2006116_4 436308.Nmar_0671 3.08e-07 53.0 arCOG10533@1|root,arCOG10533@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2013861_2 436308.Nmar_1305 9.87e-06 48.0 arCOG08805@1|root,arCOG08805@2157|Archaea,41T3X@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2013861_0 1229909.NSED_07245 2.522e-150 477.0 COG1024@1|root,arCOG00239@2157|Archaea,41SH7@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.116 ko:K15019 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00375 R03045 RC00834 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS1_k127_2013861_1 436308.Nmar_1309 7.562e-103 335.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig CMS1_k127_201640_1 436308.Nmar_1596 5.91e-81 271.0 COG1607@1|root,arCOG00773@2157|Archaea,41T2J@651137|Thaumarchaeota 651137|Thaumarchaeota I Thioesterase superfamily - - - - - - - - - - - - 4HBT CMS1_k127_201640_2 1229909.NSED_08635 2.831e-60 210.0 arCOG10592@1|root,arCOG10594@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_201640_0 1229909.NSED_08625 1.036e-93 311.0 arCOG08773@1|root,arCOG08773@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_201640_3 1229909.NSED_08620 2.971e-08 55.0 arCOG10593@1|root,arCOG10593@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2026932_0 436308.Nmar_0214 2.947e-205 642.0 COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota 651137|Thaumarchaeota F Amidohydrolase family - - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 CMS1_k127_2026932_1 436308.Nmar_0218 6.432e-104 341.0 COG0120@1|root,arCOG01122@2157|Archaea,41SJE@651137|Thaumarchaeota 651137|Thaumarchaeota G Ribose 5-phosphate isomerase - - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A CMS1_k127_2026932_2 1229909.NSED_00920 2.945e-12 68.0 arCOG08635@1|root,arCOG08635@2157|Archaea,41T54@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2031400_2 1229909.NSED_08005 1.2e-19 89.0 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp CMS1_k127_2031400_0 1229909.NSED_03480 6.528e-48 175.0 COG0517@1|root,arCOG00606@2157|Archaea 2157|Archaea I CBS domain - - - - - - - - - - - - CBS CMS1_k127_2031400_1 1229909.NSED_09720 2.245e-30 121.0 arCOG10511@1|root,arCOG10511@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2031400_3 436308.Nmar_1012 2.731e-15 81.0 COG0589@1|root,arCOG02053@2157|Archaea,41T8H@651137|Thaumarchaeota 651137|Thaumarchaeota T Universal stress protein family - - - - - - - - - - - - Usp CMS1_k127_2031400_4 1229909.NSED_07630 6.668e-09 57.0 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp CMS1_k127_2044206_0 436308.Nmar_0749 5.126e-26 110.0 arCOG10540@1|root,arCOG10540@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2044206_3 436308.Nmar_0918 1.145e-19 96.0 COG3794@1|root,arCOG02926@2157|Archaea,41T8E@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Copper binding proteins, plastocyanin azurin family - - - - - - - - - - - - Copper-bind CMS1_k127_2044206_1 436308.Nmar_0754 1.401e-23 111.0 COG1196@1|root,arCOG00371@2157|Archaea 2157|Archaea D Required for chromosome condensation and partitioning - - - - - - - - - - - - - CMS1_k127_2091228_6 1229909.NSED_02740 1.7e-16 80.0 COG1656@1|root,arCOG04290@2157|Archaea 2157|Archaea L Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C CMS1_k127_2091228_0 436308.Nmar_0543 1.07e-268 829.0 COG0422@1|root,arCOG02741@2157|Archaea,41S5Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein ThiC - - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM CMS1_k127_2091228_5 797304.Natgr_2288 9.918e-17 85.0 COG1184@1|root,arCOG01127@2157|Archaea,2XUMH@28890|Euryarchaeota,23SF4@183963|Halobacteria 183963|Halobacteria J Belongs to the eIF-2B alpha beta delta subunits family tif2Ba - - - - - - - - - - - IF-2B,NUDIX CMS1_k127_2091228_3 1229909.NSED_02760 7.002e-151 480.0 COG0722@1|root,arCOG00245@2157|Archaea,41SM0@651137|Thaumarchaeota 651137|Thaumarchaeota E Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH CMS1_k127_2091228_1 1229909.NSED_02765 9.964e-229 715.0 COG0436@1|root,COG1605@1|root,arCOG01130@2157|Archaea,arCOG02098@2157|Archaea,41SBV@651137|Thaumarchaeota 651137|Thaumarchaeota E Chorismate mutase type II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2,CM_2 CMS1_k127_2091228_2 436308.Nmar_0547 4.715e-203 635.0 COG0082@1|root,arCOG04133@2157|Archaea,41SC3@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt CMS1_k127_2091228_4 1229909.NSED_02775 7.016e-44 161.0 COG0128@1|root,arCOG04134@2157|Archaea,41S5I@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase CMS1_k127_2118387_3 1229909.NSED_09285 1.143e-42 160.0 arCOG08767@1|root,arCOG08767@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2118387_0 1229909.NSED_09290 2.003e-163 517.0 COG0524@1|root,arCOG00014@2157|Archaea,41SX4@651137|Thaumarchaeota 651137|Thaumarchaeota G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB CMS1_k127_2118387_2 1229909.NSED_09295 4.952e-59 206.0 arCOG08766@1|root,arCOG08766@2157|Archaea,41T41@651137|Thaumarchaeota 651137|Thaumarchaeota G dUTPase - - - - - - - - - - - - dUTPase_2 CMS1_k127_2118387_1 1229909.NSED_09300 1.07e-59 210.0 COG4063@1|root,arCOG03220@2157|Archaea,41T46@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrahydromethanopterin S-methyltransferase, subunit A - - 2.1.1.86 ko:K00577 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00357,M00567 R04347 RC00035,RC00113,RC02892 ko00000,ko00001,ko00002,ko01000 - - - MtrA CMS1_k127_2118387_4 1229909.NSED_09310 1.29e-17 83.0 arCOG08765@1|root,arCOG08765@2157|Archaea,41SQJ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2122003_0 436308.Nmar_1319 1.682e-151 480.0 COG0863@1|root,arCOG00115@2157|Archaea,41SZP@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA methylase - - 2.1.1.113,2.1.1.72 ko:K00571,ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase CMS1_k127_2122003_1 1229909.NSED_07310 1.75e-100 330.0 COG1205@1|root,arCOG08693@1|root,arCOG00555@2157|Archaea,arCOG08693@2157|Archaea,41SZS@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C CMS1_k127_2143355_0 1229909.NSED_05420 0.0 1185.0 COG0574@1|root,arCOG01111@2157|Archaea,41SYV@651137|Thaumarchaeota 651137|Thaumarchaeota G Pyruvate phosphate dikinase - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N CMS1_k127_2143355_1 1229909.NSED_05425 1.916e-95 314.0 COG3620@1|root,arCOG00608@2157|Archaea,41SJR@651137|Thaumarchaeota 651137|Thaumarchaeota K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - CBS,HTH_3 CMS1_k127_2143355_2 1229909.NSED_05435 1.031e-72 246.0 COG0346@1|root,arCOG02706@2157|Archaea,41SQS@651137|Thaumarchaeota 651137|Thaumarchaeota E Glyoxalase bleomycin resistance protein dioxygenase - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 CMS1_k127_2143355_3 378806.STAUR_6990 2.231e-35 145.0 COG4412@1|root,COG4412@2|Bacteria,1R3SG@1224|Proteobacteria,42SZZ@68525|delta/epsilon subdivisions,2WPD0@28221|Deltaproteobacteria,2YUKS@29|Myxococcales 28221|Deltaproteobacteria E Fungalysin metallopeptidase (M36) - - - - - - - - - - - - PA,Peptidase_M36,REJ CMS1_k127_2150913_1 1229909.NSED_01910 1.37e-170 542.0 COG0552@1|root,arCOG01227@2157|Archaea,41SCC@651137|Thaumarchaeota 651137|Thaumarchaeota U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N CMS1_k127_2150913_3 1229909.NSED_01905 2.903e-49 179.0 COG1730@1|root,arCOG01341@2157|Archaea,41SSP@651137|Thaumarchaeota 651137|Thaumarchaeota O Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding pfdA - - ko:K04797 - - - - ko00000,ko03110 - - - Prefoldin CMS1_k127_2150913_2 1229909.NSED_01900 1.205e-123 397.0 COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota 651137|Thaumarchaeota P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N CMS1_k127_2150913_0 1229909.NSED_01895 3.416e-259 810.0 COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the peptidase S8 family - - - ko:K14647 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PA,Peptidase_S8 CMS1_k127_2161144_1 436308.Nmar_0874 1.368e-137 441.0 COG3638@1|root,arCOG00206@2157|Archaea,41SY4@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC transporter - - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran CMS1_k127_2161144_0 1229909.NSED_04905 3.656e-178 563.0 COG3221@1|root,arCOG01805@2157|Archaea,41SWY@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd CMS1_k127_2223973_1 436308.Nmar_1773 2.996e-226 708.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel CMS1_k127_2223973_0 1229909.NSED_09495 2.045e-262 812.0 COG1509@1|root,arCOG03246@2157|Archaea,41SY6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM lysine 2,3-aminomutase YodO family protein - - - - - - - - - - - - - CMS1_k127_2223973_2 1229909.NSED_09490 3.292e-53 188.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N CMS1_k127_2244321_5 1459636.NTE_01565 3.325e-55 195.0 COG0475@1|root,arCOG01955@2157|Archaea,41SG1@651137|Thaumarchaeota 2157|Archaea P Sodium hydrogen exchanger - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger CMS1_k127_2244321_1 436308.Nmar_1378 1.271e-137 439.0 COG1409@1|root,arCOG01153@2157|Archaea,41SF2@651137|Thaumarchaeota 651137|Thaumarchaeota S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos CMS1_k127_2244321_0 436308.Nmar_1379 6.33e-197 616.0 COG0473@1|root,arCOG01163@2157|Archaea,41S5U@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS1_k127_2244321_3 1131266.ARWQ01000004_gene1485 3.036e-61 215.0 COG2890@1|root,arCOG00109@2157|Archaea,41SSD@651137|Thaumarchaeota 651137|Thaumarchaeota Q Methyltransferase small domain - - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS CMS1_k127_2244321_2 436308.Nmar_1381 1.185e-88 298.0 COG0030@1|root,arCOG04131@2157|Archaea,41SN0@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family - - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD CMS1_k127_2244321_4 1229909.NSED_07525 2.251e-58 203.0 COG1491@1|root,arCOG04130@2157|Archaea,41SGD@651137|Thaumarchaeota 651137|Thaumarchaeota J Protein of unknown function (DUF655) - - - ko:K07572 - - - - ko00000 - - - DUF655 CMS1_k127_2294498_0 1229909.NSED_07450 1.147e-184 590.0 COG0475@1|root,arCOG01956@2157|Archaea 2157|Archaea P Sodium hydrogen exchanger - - - - - - - - - - - - CBS,Na_H_Exchanger CMS1_k127_230631_1 436308.Nmar_0256 1.374e-168 531.0 COG2513@1|root,arCOG00581@2157|Archaea,41SEN@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoenolpyruvate phosphomutase - - - - - - - - - - - - PEP_mutase CMS1_k127_230631_3 1229909.NSED_01175 1.118e-51 184.0 COG1581@1|root,arCOG01753@2157|Archaea,41SQ4@651137|Thaumarchaeota 651137|Thaumarchaeota K Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes - - - ko:K03622 - - - - ko00000 - - - Alba CMS1_k127_230631_2 1229909.NSED_01170 9.484e-58 206.0 COG1413@1|root,arCOG02966@2157|Archaea,41T3Y@651137|Thaumarchaeota 651137|Thaumarchaeota C HEAT repeats - - - - - - - - - - - - - CMS1_k127_230631_0 436308.Nmar_0253 9.337e-170 535.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 CMS1_k127_230631_4 1229909.NSED_01160 4.572e-51 182.0 COG1056@1|root,arCOG00972@2157|Archaea,41SHQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Nicotinamide-nucleotide adenylyltransferase - - - - - - - - - - - - - CMS1_k127_2315519_4 1459636.NTE_00613 2.003e-80 275.0 COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 CMS1_k127_2315519_0 436308.Nmar_0290 3.455e-182 574.0 COG3875@1|root,arCOG02046@2157|Archaea,41SK4@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF2088) - - - - - - - - - - - - - CMS1_k127_2315519_3 436308.Nmar_0289 6.171e-98 323.0 COG0461@1|root,arCOG00029@2157|Archaea,41SJU@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran CMS1_k127_2315519_1 436308.Nmar_0288 3.385e-128 412.0 COG5424@1|root,arCOG06031@2157|Archaea,41SJK@651137|Thaumarchaeota 651137|Thaumarchaeota H Iron-containing redox enzyme - - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - - CMS1_k127_2315519_2 436308.Nmar_0287 8.722e-125 401.0 COG0142@1|root,arCOG01727@2157|Archaea,41SC6@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the FPP GGPP synthase family - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt CMS1_k127_232253_4 1229909.NSED_00210 1.791e-75 256.0 COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatD - 6.3.5.7 ko:K09482 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - Asparaginase CMS1_k127_232253_0 1229909.NSED_00215 0.0 1363.0 COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N CMS1_k127_232253_2 1229909.NSED_00220 4.931e-140 448.0 COG0090@1|root,arCOG04067@2157|Archaea,41SCT@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rpl2 - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C CMS1_k127_232253_5 436308.Nmar_0103 1.805e-37 144.0 COG1254@1|root,arCOG01674@2157|Archaea,41SRG@651137|Thaumarchaeota 651137|Thaumarchaeota C Acylphosphatase - - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase CMS1_k127_232253_1 436308.Nmar_0105 3.616e-163 516.0 COG0037@1|root,arCOG00042@2157|Archaea,41S84@651137|Thaumarchaeota 651137|Thaumarchaeota D PP-loop family - - - - - - - - - - - - ATP_bind_3 CMS1_k127_232253_3 436308.Nmar_0107 9.618e-85 282.0 COG0750@1|root,arCOG04064@2157|Archaea,41SW5@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - PDZ_2,Peptidase_M50 CMS1_k127_2327721_2 1229909.NSED_01555 1.296e-89 297.0 COG2038@1|root,arCOG04272@2157|Archaea,41SD3@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the UPF0284 family - - - - - - - - - - - - DBI_PRT CMS1_k127_2327721_1 436308.Nmar_0321 7.354e-107 348.0 arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota 651137|Thaumarchaeota S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B CMS1_k127_2327721_0 436308.Nmar_0320 1.078e-114 372.0 COG0063@1|root,arCOG00018@2157|Archaea,41SHM@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX nnrE - 5.1.99.6 ko:K17759 - - - - ko00000,ko01000 - - - YjeF_N CMS1_k127_2327721_3 1229909.NSED_00340 2.141e-49 187.0 arCOG08796@1|root,arCOG08796@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2327721_4 436308.Nmar_0319 8.713e-36 138.0 COG2178@1|root,arCOG04318@2157|Archaea,41SKR@651137|Thaumarchaeota 651137|Thaumarchaeota J Translin family - - - ko:K07477 - - - - ko00000 - - - Translin CMS1_k127_2333268_1 436308.Nmar_0501 5.766e-72 246.0 COG0671@1|root,arCOG03056@2157|Archaea,41SQ8@651137|Thaumarchaeota 651137|Thaumarchaeota I Acid phosphatase homologues - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 CMS1_k127_2333268_3 436308.Nmar_0500 7.056e-53 188.0 COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK CMS1_k127_2333268_2 436308.Nmar_0500 3.716e-67 229.0 COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK CMS1_k127_2333268_0 1229909.NSED_02510 3.991e-93 307.0 COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK CMS1_k127_2333268_4 1229909.NSED_02505 2.566e-43 160.0 arCOG08758@1|root,arCOG08758@2157|Archaea,41SVS@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2334816_3 436308.Nmar_1298 9.809e-78 264.0 COG0615@1|root,arCOG01222@2157|Archaea,41SPR@651137|Thaumarchaeota 651137|Thaumarchaeota M Cytidylyltransferase-like - - 2.7.7.2,2.7.7.39 ko:K00980,ko:K14656 ko00564,ko00740,ko01100,ko01110,map00564,map00740,map01100,map01110 - R00161,R00856 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like CMS1_k127_2334816_1 1229909.NSED_07210 3.041e-106 348.0 COG1339@1|root,arCOG01904@2157|Archaea,41SG9@651137|Thaumarchaeota 651137|Thaumarchaeota H Domain of unknown function DUF120 - - 2.7.1.161 ko:K07732 ko00740,ko01100,map00740,map01100 - R08574 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CTP-dep_RFKase CMS1_k127_2334816_0 1229909.NSED_07215 4.567e-209 653.0 COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA primase dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4 CMS1_k127_2334816_4 436308.Nmar_1303 1.067e-64 222.0 COG0316@1|root,arCOG04560@2157|Archaea,41SKH@651137|Thaumarchaeota 651137|Thaumarchaeota O Iron-sulfur cluster assembly accessory protein - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn CMS1_k127_2334816_5 1229909.NSED_07225 1.695e-35 139.0 COG0517@1|root,arCOG00606@2157|Archaea 2157|Archaea I CBS domain - - - - - - - - - - - - CBS CMS1_k127_2334816_2 436308.Nmar_1305 1.877e-83 279.0 arCOG08805@1|root,arCOG08805@2157|Archaea,41T3X@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2340972_1 1229909.NSED_08450 5.651e-66 225.0 COG1145@1|root,arCOG00291@2157|Archaea,41SNB@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase - - - - - - - - - - - - Fer4 CMS1_k127_2340972_2 1229909.NSED_08455 1.292e-33 130.0 arCOG08782@1|root,arCOG08782@2157|Archaea,41SVH@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2340972_0 1229909.NSED_08460 1.557e-181 571.0 COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota 651137|Thaumarchaeota J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07577 - - - - ko00000 - - - Beta-Casp,Lactamase_B_6,RMMBL CMS1_k127_2349424_0 1041930.Mtc_1620 2.878e-169 545.0 COG2217@1|root,COG3350@1|root,arCOG01576@2157|Archaea,arCOG04507@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia 224756|Methanomicrobia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase CMS1_k127_2349424_1 1229909.NSED_06840 3.389e-23 106.0 COG4263@1|root,arCOG06217@2157|Archaea 2157|Archaea C Cytochrome C oxidase, subunit II nosZ - 1.7.2.4,1.9.3.1 ko:K00376,ko:K02275 ko00190,ko00910,ko01100,ko01120,map00190,map00910,map01100,map01120 M00155,M00529 R00081,R02804 RC00016,RC02861 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,Cupredoxin_1,TAT_signal CMS1_k127_2352019_0 436308.Nmar_0944 2.416e-255 794.0 COG1111@1|root,arCOG00872@2157|Archaea 2157|Archaea L DEAD DEAH box helicase domain protein - - - ko:K03703,ko:K10896 ko03420,ko03460,map03420,map03460 M00413 - - ko00000,ko00001,ko00002,ko03400 - - - DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII CMS1_k127_2352019_1 436308.Nmar_0943 2.302e-09 60.0 arCOG11285@1|root,arCOG11285@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2448923_3 1229909.NSED_06295 0.0002496 43.0 arCOG08700@1|root,arCOG08700@2157|Archaea,41SV2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2448923_2 436308.Nmar_1080 1.633e-44 162.0 COG1436@1|root,arCOG04102@2157|Archaea,41T76@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (F/14-kDa) subunit - - - ko:K02122 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_F CMS1_k127_2448923_0 436308.Nmar_1079 1.01e-187 589.0 COG1063@1|root,arCOG01459@2157|Archaea,41S98@651137|Thaumarchaeota 651137|Thaumarchaeota C Glucose dehydrogenase C-terminus - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_2448923_1 436308.Nmar_1078 3.216e-145 467.0 COG1830@1|root,arCOG04044@2157|Archaea,41S64@651137|Thaumarchaeota 651137|Thaumarchaeota E DeoC/LacD family aldolase - - 2.3.1.245 ko:K08321 ko02024,map02024 - - - ko00000,ko00001,ko01000 - - - DeoC CMS1_k127_2497048_0 436308.Nmar_1455 1.006e-249 775.0 COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota 651137|Thaumarchaeota F adenylosuccinate lyase - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 CMS1_k127_2497048_1 436308.Nmar_0587 3.548e-36 140.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - DUF2226,P-II CMS1_k127_2497048_2 1229909.NSED_06370 4.049e-34 134.0 arCOG00516@1|root,arCOG00516@2157|Archaea,41SQT@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx CMS1_k127_2510409_2 1229909.NSED_00515 2.152e-45 172.0 arCOG07810@1|root,arCOG07810@2157|Archaea,41T4X@651137|Thaumarchaeota 2157|Archaea T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - - - - - - - - - - - Guanylate_cyc CMS1_k127_2510409_1 1229909.NSED_07855 3.958e-47 172.0 COG3794@1|root,arCOG02926@2157|Archaea,41TAN@651137|Thaumarchaeota 651137|Thaumarchaeota C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind CMS1_k127_2510409_3 436308.Nmar_1432 3.005e-30 120.0 COG2036@1|root,arCOG02144@2157|Archaea,41T91@651137|Thaumarchaeota 651137|Thaumarchaeota L transcription factor (CBF NF-Y) - - - - - - - - - - - - CBFD_NFYB_HMF CMS1_k127_2510409_0 436308.Nmar_1431 5.939e-111 363.0 COG0084@1|root,arCOG00891@2157|Archaea,41SGP@651137|Thaumarchaeota 651137|Thaumarchaeota L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase CMS1_k127_2510409_4 1229909.NSED_07840 2.11e-19 92.0 COG1383@1|root,arCOG01885@2157|Archaea,41SUH@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02962 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17e CMS1_k127_2520967_6 1229909.NSED_07360 1.18e-10 62.0 arCOG08684@1|root,arCOG08684@2157|Archaea,41T81@651137|Thaumarchaeota 651137|Thaumarchaeota S COG4618 ABC-type protease lipase transport system, ATPase and permease components - - - - - - - - - - - - - CMS1_k127_2520967_1 1229909.NSED_01215 3.253e-239 746.0 COG0165@1|root,arCOG01748@2157|Archaea,41S6A@651137|Thaumarchaeota 651137|Thaumarchaeota E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 CMS1_k127_2520967_4 436308.Nmar_0262 1.52e-66 227.0 COG2151@1|root,arCOG01845@2157|Archaea,41SQV@651137|Thaumarchaeota 651137|Thaumarchaeota S Iron-sulfur cluster assembly protein - - - - - - - - - - - - FeS_assembly_P CMS1_k127_2520967_2 436308.Nmar_0261 2.776e-146 465.0 COG0479@1|root,arCOG00962@2157|Archaea,41SAW@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein - - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 CMS1_k127_2520967_5 1229909.NSED_01200 4.442e-58 203.0 COG2142@1|root,arCOG04162@2157|Archaea,41SRA@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt CMS1_k127_2520967_3 436308.Nmar_0259 6.675e-77 258.0 COG2009@1|root,arCOG02244@2157|Archaea,41SKZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt CMS1_k127_2520967_0 436308.Nmar_0258 1.692e-246 763.0 COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota 651137|Thaumarchaeota C fumarate reductase flavoprotein - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS1_k127_2528405_5 1229909.NSED_02210 1.677e-81 272.0 COG0088@1|root,arCOG04243@2157|Archaea,41SKT@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the universal ribosomal protein uS9 family - - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 CMS1_k127_2528405_6 1229909.NSED_02215 5.292e-64 222.0 COG0102@1|root,arCOG04242@2157|Archaea,41SP4@651137|Thaumarchaeota 651137|Thaumarchaeota J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rpl13 - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 CMS1_k127_2528405_8 399549.Msed_2144 3.227e-18 89.0 COG1727@1|root,arCOG00780@2157|Archaea,2XQV1@28889|Crenarchaeota 28889|Crenarchaeota J Belongs to the eukaryotic ribosomal protein eL18 family rpl18e GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02883 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18,Ribosomal_L27A CMS1_k127_2528405_4 436308.Nmar_0428 7.93e-111 360.0 COG0202@1|root,arCOG04241@2157|Archaea,41SK0@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-directed RNA polymerase, alpha subunit 40 kD subunit - - 2.7.7.6 ko:K03047 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_A_bac,RNA_pol_L CMS1_k127_2528405_3 436308.Nmar_0430 1.909e-119 386.0 COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota 651137|Thaumarchaeota J Shwachman-Bodian-Diamond syndrome (SBDS) protein - - - ko:K14574 ko03008,map03008 - - - ko00000,ko00001,ko03009 - - - SBDS,SBDS_C CMS1_k127_2528405_2 1229909.NSED_02240 5.577e-130 417.0 COG1097@1|root,arCOG00678@2157|Archaea,41SHV@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome rrp4 - - ko:K03679 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - KH_1 CMS1_k127_2528405_0 1229909.NSED_02245 9.504e-143 454.0 COG0689@1|root,arCOG01575@2157|Archaea,41S81@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails rrp41 - - ko:K11600 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - RNase_PH,RNase_PH_C CMS1_k127_2528405_1 436308.Nmar_0433 1.02e-141 452.0 COG2123@1|root,arCOG01574@2157|Archaea,41SFZ@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site rrp42 - - ko:K12589 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - RNase_PH,RNase_PH_C CMS1_k127_2528405_7 436308.Nmar_0434 1.575e-33 130.0 COG1997@1|root,arCOG04208@2157|Archaea,41SUE@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal L37ae protein family rpl37ae - - ko:K02921 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L37ae CMS1_k127_2530089_1 1229909.NSED_05085 5.039e-60 213.0 COG1468@1|root,arCOG00786@2157|Archaea 2157|Archaea L TIGRFAM CRISPR-associated protein Cas4 - - 3.1.12.1 ko:K03466,ko:K07464,ko:K15342,ko:K19465 - - - - ko00000,ko01000,ko02048,ko03029,ko03036,ko03400 3.A.12 - - Cas_Cas4,FtsK_SpoIIIE,PDDEXK_1 CMS1_k127_2530089_2 436308.Nmar_0436 1.586e-41 156.0 COG1382@1|root,arCOG01342@2157|Archaea,41SPD@651137|Thaumarchaeota 651137|Thaumarchaeota O Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding pfdB - - ko:K04798 - - - - ko00000,ko03110 - - - Prefoldin_2 CMS1_k127_2530089_0 1229909.NSED_02270 3.334e-120 389.0 COG1948@1|root,arCOG04206@2157|Archaea,41SIH@651137|Thaumarchaeota 651137|Thaumarchaeota L ERCC4 domain - - - ko:K10848 ko03420,ko03460,map03420,map03460 - - - ko00000,ko00001,ko01000,ko03032,ko03400 - - - ERCC4,HHH_5 CMS1_k127_2530089_3 1229909.NSED_02275 3.226e-15 75.0 COG1439@1|root,arCOG00721@2157|Archaea,41SPQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PIN domain of ribonuclease - - - ko:K07060 - - - - ko00000,ko01000,ko02048 - - - PIN_6 CMS1_k127_2532901_1 436308.Nmar_1653 1.951e-69 237.0 COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC 3 transport family - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 CMS1_k127_2532901_0 1229909.NSED_08955 3.872e-133 427.0 COG1121@1|root,arCOG00201@2157|Archaea,41S7E@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM ABC transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran CMS1_k127_2532901_2 1459636.NTE_00032 4.81e-61 220.0 COG0803@1|root,arCOG01005@2157|Archaea,41T29@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA CMS1_k127_2533946_0 1229909.NSED_05215 2.7e-78 263.0 COG2522@1|root,arCOG00017@2157|Archaea,41SJZ@651137|Thaumarchaeota 651137|Thaumarchaeota S Transcriptional regulator - - - ko:K07108 - - - - ko00000 - - - - CMS1_k127_2533946_4 436308.Nmar_0933 1e-28 117.0 COG1581@1|root,arCOG01753@2157|Archaea,41TA9@651137|Thaumarchaeota 651137|Thaumarchaeota K Alba - - - ko:K03622 - - - - ko00000 - - - Alba CMS1_k127_2533946_1 436308.Nmar_0932 3.037e-78 266.0 COG1758@1|root,arCOG01268@2157|Archaea,41ST9@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoK - - ko:K03014 ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169 M00180,M00181,M00182 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko03021,ko03400 - - - RNA_pol_Rpb6 CMS1_k127_2533946_2 1229909.NSED_05200 3.198e-50 185.0 COG2164@1|root,arCOG04488@2157|Archaea,41STM@651137|Thaumarchaeota 651137|Thaumarchaeota S Cyclophilin-like - - - ko:K09143 - - - - ko00000 - - - Cyclophil_like CMS1_k127_2533946_3 1229909.NSED_05190 1.308e-30 121.0 arCOG05330@1|root,arCOG05330@2157|Archaea,41SUC@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2561243_1 436308.Nmar_0677 2.253e-74 255.0 arCOG04668@1|root,arCOG04668@2157|Archaea,41SMD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2561243_0 436308.Nmar_0672 1.429e-193 606.0 COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota 651137|Thaumarchaeota O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_2561243_2 436308.Nmar_0671 4.051e-16 81.0 arCOG10533@1|root,arCOG10533@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2566208_0 1459636.NTE_01510 1.455e-17 96.0 arCOG02362@1|root,arCOG02362@2157|Archaea 1459636.NTE_01510|- - - - - - - - - - - - - - - - CMS1_k127_2566208_1 436308.Nmar_0189 5.903e-15 87.0 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA CMS1_k127_2569195_0 1229909.NSED_05445 4.092e-39 151.0 COG0589@1|root,arCOG02053@2157|Archaea,41T8H@651137|Thaumarchaeota 651137|Thaumarchaeota T Universal stress protein family - - - - - - - - - - - - Usp CMS1_k127_2569195_1 1229909.NSED_05440 3.216e-35 139.0 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - 2.7.13.3 ko:K07646,ko:K20989 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 2.A.21.6 - - DUF4118,GAF_3,KdpD,Usp CMS1_k127_2569195_2 1229909.NSED_05375 7.178e-07 51.0 arCOG02703@1|root,arCOG02703@2157|Archaea 2157|Archaea S Methyltransferase type 11 - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 CMS1_k127_2571382_0 436308.Nmar_0652 1.752e-161 512.0 COG4608@1|root,arCOG00184@2157|Archaea,41S9E@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY CMS1_k127_2571382_1 436308.Nmar_0651 4.406e-109 354.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge CMS1_k127_2578212_3 436308.Nmar_0491 2.919e-94 312.0 COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC CMS1_k127_2578212_1 1229909.NSED_02465 6.301e-142 452.0 COG0007@1|root,arCOG00644@2157|Archaea,41S9J@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the precorrin methyltransferase family - - 2.1.1.107 ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - TP_methylase CMS1_k127_2578212_2 1229909.NSED_02470 3.13e-134 431.0 COG1587@1|root,arCOG02048@2157|Archaea,41SN2@651137|Thaumarchaeota 651137|Thaumarchaeota H Uroporphyrinogen-III synthase HemD - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 CMS1_k127_2578212_4 1120998.AUFC01000039_gene3003 3.719e-13 74.0 COG0745@1|root,COG0745@2|Bacteria 1120998.AUFC01000039_gene3003|- T phosphorelay signal transduction system - - - - - - - - - - - - - CMS1_k127_2578212_0 436308.Nmar_0495 2.897e-154 488.0 COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufB - - - ko:K09014 - - - - ko00000 - - - UPF0051 CMS1_k127_2591758_0 436308.Nmar_1644 6.286e-182 578.0 arCOG08728@1|root,arCOG08728@2157|Archaea,41SW1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2591758_1 1229909.NSED_08915 4.565e-118 385.0 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2592388_0 1229909.NSED_06385 7.498e-191 598.0 COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM 2-methylcitrate synthase citrate synthase II - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt CMS1_k127_2592388_1 436308.Nmar_1100 3.874e-36 139.0 arCOG08706@1|root,arCOG08706@2157|Archaea,41SUP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2592388_2 436308.Nmar_1101 2.683e-32 129.0 arCOG10574@1|root,arCOG10574@2157|Archaea,41T8I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2597350_3 1229909.NSED_01255 2.303e-27 111.0 arCOG08784@1|root,arCOG08784@2157|Archaea,41SVZ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2597350_0 1229909.NSED_01250 2.059e-210 658.0 COG0470@1|root,arCOG00470@2157|Archaea,41S9F@651137|Thaumarchaeota 651137|Thaumarchaeota L ATPase family associated with various cellular activities (AAA) - - - ko:K04800 ko03030,map03030 - - - ko00000,ko00001,ko03032 - - - AAA CMS1_k127_2597350_1 1229909.NSED_01245 3.974e-198 621.0 arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2597350_2 1229909.NSED_01240 4.243e-75 253.0 COG0483@1|root,arCOG01349@2157|Archaea,41SIF@651137|Thaumarchaeota 651137|Thaumarchaeota G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P CMS1_k127_2606913_2 436308.Nmar_0187 2.442e-25 107.0 arCOG08825@1|root,arCOG08825@2157|Archaea,41T4G@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2606913_0 1229909.NSED_00415 2.248e-118 382.0 COG4276@1|root,arCOG04604@2157|Archaea,41SI9@651137|Thaumarchaeota 651137|Thaumarchaeota S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - Polyketide_cyc2 CMS1_k127_2606913_1 436308.Nmar_0190 2.575e-81 274.0 COG0500@1|root,arCOG01773@2157|Archaea 2157|Archaea Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 CMS1_k127_2626173_4 436308.Nmar_1254 2.638e-81 273.0 COG1632@1|root,arCOG04209@2157|Archaea,41SND@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein L15E - - - ko:K02877 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L15e CMS1_k127_2626173_6 1229909.NSED_07040 1.98e-60 215.0 arCOG08778@1|root,arCOG08778@2157|Archaea,41T5W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2626173_7 436308.Nmar_1256 5.485e-28 119.0 arCOG12843@1|root,arCOG12843@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2626173_5 436308.Nmar_1257 2.581e-80 276.0 arCOG08033@1|root,arCOG08033@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - CMS1_k127_2626173_3 436308.Nmar_1258 1.181e-173 548.0 COG0111@1|root,arCOG01754@2157|Archaea,41S8U@651137|Thaumarchaeota 651137|Thaumarchaeota H D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C CMS1_k127_2626173_0 436308.Nmar_1259 1.435e-279 862.0 COG2132@1|root,arCOG03914@2157|Archaea,41SZT@651137|Thaumarchaeota 651137|Thaumarchaeota Q Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cu-oxidase_3 CMS1_k127_2626173_1 1229909.NSED_07065 1.34e-261 809.0 COG1027@1|root,arCOG01750@2157|Archaea,41S9C@651137|Thaumarchaeota 651137|Thaumarchaeota E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 CMS1_k127_2626173_2 436308.Nmar_1261 9.562e-225 701.0 COG0621@1|root,arCOG01358@2157|Archaea,41SB9@651137|Thaumarchaeota 651137|Thaumarchaeota J MiaB-like tRNA modifying enzyme - - 2.8.4.5 ko:K15865 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 CMS1_k127_2626173_8 436308.Nmar_1262 3.007e-17 83.0 COG0206@1|root,arCOG02201@2157|Archaea,41SG8@651137|Thaumarchaeota 651137|Thaumarchaeota D Tubulin/FtsZ family, GTPase domain - - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - Tubulin CMS1_k127_2632501_2 1229909.NSED_00750 1.087e-55 195.0 COG0139@1|root,arCOG02676@2157|Archaea,41SPE@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH CMS1_k127_2632501_1 1229909.NSED_00755 5.556e-63 224.0 arCOG08828@1|root,arCOG08828@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2632501_0 1229909.NSED_00760 1.677e-150 477.0 COG0498@1|root,arCOG01434@2157|Archaea,41SEI@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_2654794_0 1229909.NSED_07115 9.952e-230 729.0 COG2132@1|root,COG3391@1|root,COG3794@1|root,arCOG02562@2157|Archaea,arCOG02926@2157|Archaea,arCOG03914@2157|Archaea 2157|Archaea Q Multicopper - - - - - - - - - - - - Lactonase CMS1_k127_2654794_2 436308.Nmar_1269 7.179e-178 563.0 COG0477@1|root,arCOG00130@2157|Archaea 2157|Archaea EGP Major facilitator superfamily - - - ko:K08153 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8 - - MFS_1,PUCC CMS1_k127_2654794_1 436308.Nmar_1268 2.594e-196 613.0 COG0646@1|root,arCOG08715@2157|Archaea,41SWZ@651137|Thaumarchaeota 651137|Thaumarchaeota E homocysteine S-methyltransferase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - S-methyl_trans CMS1_k127_2654794_3 436308.Nmar_1267 8.512e-37 139.0 COG0294@1|root,COG1410@1|root,arCOG02029@2157|Archaea,arCOG02817@2157|Archaea,41SXT@651137|Thaumarchaeota 651137|Thaumarchaeota E Methionine synthase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind CMS1_k127_2671509_1 330214.NIDE2792 1.929e-48 186.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - NHL CMS1_k127_2671509_0 436308.Nmar_1457 9.108e-159 506.0 arCOG01778@1|root,arCOG01778@2157|Archaea,41SXW@651137|Thaumarchaeota 651137|Thaumarchaeota Q O-methyltransferase - - - - - - - - - - - - Methyltransf_31 CMS1_k127_2674768_4 1229909.NSED_01235 2.633e-13 70.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 CMS1_k127_2674768_2 1229909.NSED_01230 7.467e-22 95.0 COG5466@1|root,arCOG05278@2157|Archaea,41T8X@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF1059) - - - - - - - - - - - - DUF1059 CMS1_k127_2674768_0 436308.Nmar_0265 2.412e-137 448.0 COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) - - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,Shikimate_DH CMS1_k127_2674768_1 1131266.ARWQ01000032_gene1006 1.089e-39 156.0 arCOG08785@1|root,arCOG08785@2157|Archaea,41SVD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - ko:K03646 - - - - ko00000,ko02000 2.C.1.2 - - - CMS1_k127_2674768_3 436308.Nmar_0271 3.944e-17 81.0 arCOG08784@1|root,arCOG08784@2157|Archaea,41SVZ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2676003_1 1341151.ASZU01000014_gene2149 2.752e-73 262.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,4H9WH@91061|Bacilli,27B4H@186824|Thermoactinomycetaceae 91061|Bacilli P Rhodanese Homology Domain - - - - - - - - - - - - Lactamase_B,Rhodanese CMS1_k127_2676003_3 1163730.FFONT_0008 1.415e-65 232.0 COG0730@1|root,arCOG02050@2157|Archaea,2XQGT@28889|Crenarchaeota 28889|Crenarchaeota S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_2676003_0 1229909.NSED_01760 2.699e-117 379.0 COG2013@1|root,arCOG01907@2157|Archaea,41T1Q@651137|Thaumarchaeota 651137|Thaumarchaeota S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 CMS1_k127_2676003_2 436308.Nmar_1467 7.599e-66 229.0 COG1525@1|root,arCOG03192@2157|Archaea 2157|Archaea L COG1525 Micrococcal nuclease (thermonuclease) homologs - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase CMS1_k127_2682941_1 436308.Nmar_1109 4.679e-90 297.0 COG2141@1|root,arCOG02410@2157|Archaea,41SBM@651137|Thaumarchaeota 651137|Thaumarchaeota C Luciferase-like monooxygenase - - - ko:K14728 - - - - ko00000,ko01000 - - - Bac_luciferase CMS1_k127_2682941_0 1229909.NSED_06440 4.939e-200 623.0 COG1454@1|root,arCOG00984@2157|Archaea,41SFC@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Iron-containing alcohol dehydrogenase - - - ko:K18602 ko00720,ko01120,map00720,map01120 - R09289 RC00087 ko00000,ko00001,ko01000 - - - Fe-ADH CMS1_k127_2682941_2 436308.Nmar_1111 2.794e-08 56.0 COG2379@1|root,arCOG04170@2157|Archaea,41SJF@651137|Thaumarchaeota 651137|Thaumarchaeota G MOFRL family - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL CMS1_k127_2691998_2 1229909.NSED_02290 6.493e-50 179.0 arCOG08760@1|root,arCOG08760@2157|Archaea,41T7P@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2691998_0 1229909.NSED_02285 4.933e-182 569.0 COG2897@1|root,arCOG02019@2157|Archaea,41SZQ@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese CMS1_k127_2691998_1 436308.Nmar_0440 7.463e-148 471.0 COG0061@1|root,arCOG01348@2157|Archaea,41SHP@651137|Thaumarchaeota 651137|Thaumarchaeota H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase CMS1_k127_2691998_3 1459636.NTE_01350 1.242e-21 98.0 COG1439@1|root,arCOG00721@2157|Archaea,41SPQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PIN domain of ribonuclease - - - ko:K07060 - - - - ko00000,ko01000,ko02048 - - - PIN_6 CMS1_k127_2706132_5 1229909.NSED_09310 2.924e-72 245.0 arCOG08765@1|root,arCOG08765@2157|Archaea,41SQJ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2706132_8 1229909.NSED_09315 1.735e-27 112.0 arCOG08679@1|root,arCOG08679@2157|Archaea 2157|Archaea S zinc finger - - - - - - - - - - - - - CMS1_k127_2706132_2 436308.Nmar_1751 7.219e-195 611.0 COG0162@1|root,arCOG01886@2157|Archaea,41S8C@651137|Thaumarchaeota 651137|Thaumarchaeota J Tyrosine--tRNA ligase - - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - tRNA-synt_1b CMS1_k127_2706132_3 1229909.NSED_09330 7.687e-153 485.0 COG1010@1|root,arCOG00647@2157|Archaea,41S6W@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.131 ko:K05934 ko00860,ko01100,map00860,map01100 - R05180,R05809 RC00003,RC01293,RC03471 ko00000,ko00001,ko01000 - - - TP_methylase CMS1_k127_2706132_1 436308.Nmar_1753 4.49e-207 654.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2706132_0 1229909.NSED_09340 4.117e-240 748.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 CMS1_k127_2706132_4 436308.Nmar_1755 6.404e-141 450.0 COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota 651137|Thaumarchaeota L Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication pcn - - ko:K04802 ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166 M00295 - - ko00000,ko00001,ko00002,ko03032,ko03400 - - - PCNA_C,PCNA_N CMS1_k127_2706132_6 436308.Nmar_1756 1.901e-43 160.0 COG1594@1|root,arCOG00579@2157|Archaea,41SS3@651137|Thaumarchaeota 651137|Thaumarchaeota K Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family - - - ko:K03057 ko01100,map01100 - - - br01611,ko00000,ko03021 - - - TFIIS_C CMS1_k127_2706132_7 1229909.NSED_09355 2.283e-39 148.0 COG1761@1|root,arCOG04111@2157|Archaea,41SV9@651137|Thaumarchaeota 651137|Thaumarchaeota K RNA polymerase Rpb3/Rpb11 dimerisation domain - - 2.7.7.6 ko:K03056 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_L_2 CMS1_k127_270614_3 436308.Nmar_1382 5.683e-31 122.0 COG1491@1|root,arCOG04130@2157|Archaea,41SGD@651137|Thaumarchaeota 651137|Thaumarchaeota J Protein of unknown function (DUF655) - - - ko:K07572 - - - - ko00000 - - - DUF655 CMS1_k127_270614_1 436308.Nmar_1383 7.253e-54 190.0 COG1460@1|root,arCOG01016@2157|Archaea,41SQ1@651137|Thaumarchaeota 651137|Thaumarchaeota K RNA polymerase Rpb4 - - 2.7.7.6 ko:K03051 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb4 CMS1_k127_270614_2 436308.Nmar_1384 9.679e-52 184.0 COG2139@1|root,arCOG04129@2157|Archaea,41SRF@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eL21 family rpl21e - - ko:K02889 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21e CMS1_k127_270614_4 1229909.NSED_02840 1.015e-08 64.0 arCOG11721@1|root,arCOG11721@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_270614_0 1229909.NSED_04620 2.109e-112 368.0 COG0500@1|root,arCOG12822@1|root,arCOG01631@2157|Archaea,arCOG12822@2157|Archaea,41TBE@651137|Thaumarchaeota 2157|Archaea Q RNA methylase - - - - - - - - - - - - - CMS1_k127_2722404_1 1229909.NSED_07870 1.572e-62 216.0 arCOG08730@1|root,arCOG08730@2157|Archaea,41SNH@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2722404_2 1229909.NSED_07865 5.769e-16 79.0 arCOG08678@1|root,arCOG08678@2157|Archaea,41TA6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2722404_0 436308.Nmar_1444 0.0 1026.0 arCOG06613@1|root,arCOG06613@2157|Archaea,41T0Z@651137|Thaumarchaeota 651137|Thaumarchaeota V AIPR protein - - - - - - - - - - - - AIPR CMS1_k127_2774817_1 436308.Nmar_1193 1.634e-185 583.0 COG1064@1|root,arCOG01455@2157|Archaea,41SK3@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_2774817_4 436308.Nmar_1192 1.641e-26 109.0 arCOG08692@1|root,arCOG08692@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2774817_0 436308.Nmar_1191 0.0 1114.0 COG1331@1|root,arCOG02007@2157|Archaea,41SHZ@651137|Thaumarchaeota 651137|Thaumarchaeota O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH CMS1_k127_2774817_2 1229909.NSED_06775 3.028e-51 183.0 arCOG08080@1|root,arCOG08080@2157|Archaea,41SUA@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2774817_3 436308.Nmar_1189 4.422e-39 147.0 arCOG08691@1|root,arCOG08691@2157|Archaea,41T93@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2779213_2 436308.Nmar_0597 2.34e-56 198.0 COG0073@1|root,arCOG01136@2157|Archaea,41SSY@651137|Thaumarchaeota 651137|Thaumarchaeota J Putative tRNA binding domain - - - ko:K06878 - - - - ko00000 - - - tRNA_bind CMS1_k127_2779213_0 436308.Nmar_0598 3.95e-105 342.0 COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota 651137|Thaumarchaeota K General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation - - - ko:K03120 ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203 - - - ko00000,ko00001,ko03000,ko03021 - - - TBP CMS1_k127_2779213_1 436308.Nmar_0599 2.619e-97 322.0 COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF1512) - - - - - - - - - - - - DUF1512 CMS1_k127_2779761_0 1229909.NSED_01805 3.554e-286 884.0 COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS1_k127_279158_1 436308.Nmar_1366 4.793e-97 323.0 COG0500@1|root,COG2835@1|root,arCOG01791@2157|Archaea,arCOG04124@2157|Archaea,41T4S@651137|Thaumarchaeota 651137|Thaumarchaeota Q Methyltransferase domain - - - - - - - - - - - - - CMS1_k127_279158_2 1229909.NSED_02035 5.841e-08 56.0 arCOG11430@1|root,arCOG11430@2157|Archaea 1229909.NSED_02035|- - - - - - - - - - - - - - - - CMS1_k127_279158_0 436308.Nmar_0380 1.492e-107 353.0 arCOG10517@1|root,arCOG10517@2157|Archaea,41T0I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2815024_0 436308.Nmar_1034 4.429e-259 799.0 COG5256@1|root,arCOG01561@2157|Archaea,41SD2@651137|Thaumarchaeota 651137|Thaumarchaeota J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K03231 ko03013,ko05134,map03013,map05134 - - - ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 CMS1_k127_2815024_1 436308.Nmar_1033 1.862e-61 211.0 COG0051@1|root,arCOG01758@2157|Archaea,41SQB@651137|Thaumarchaeota 651137|Thaumarchaeota J Involved in the binding of tRNA to the ribosomes rps10 - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 CMS1_k127_2815024_2 1229909.NSED_06080 1.82e-11 64.0 COG1996@1|root,arCOG04341@2157|Archaea,41SWH@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - - 2.7.7.6 ko:K03059 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - - CMS1_k127_2817504_0 436308.Nmar_0809 4.923e-177 558.0 COG0087@1|root,arCOG04070@2157|Archaea,41SDN@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein L3 - - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 CMS1_k127_2817504_2 436308.Nmar_0810 1.781e-130 421.0 COG2106@1|root,arCOG04069@2157|Archaea,41SI7@651137|Thaumarchaeota 651137|Thaumarchaeota S Putative RNA methyltransferase - - - ko:K09142 - - - - ko00000 - - - Methyltrn_RNA_3 CMS1_k127_2817504_1 1229909.NSED_04495 1.558e-132 425.0 COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota 651137|Thaumarchaeota O Proteasome endopeptidase complex - - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome,Proteasome_A_N CMS1_k127_2817504_3 1229909.NSED_04500 1.042e-54 194.0 COG2090@1|root,arCOG04171@2157|Archaea,41SNF@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF371) - - - ko:K09738 - - - - ko00000 - - - DUF371 CMS1_k127_28322_1 1229909.NSED_00910 7.857e-64 224.0 COG3794@1|root,arCOG02926@2157|Archaea 1229909.NSED_00910|- C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - CMS1_k127_28322_0 436308.Nmar_0471 0.0 1041.0 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel CMS1_k127_28322_2 436308.Nmar_0472 3.07e-18 85.0 COG0640@1|root,arCOG01686@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_20 CMS1_k127_2847933_1 1229909.NSED_05065 1.052e-55 196.0 arCOG07348@1|root,arCOG07348@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2847933_0 1229909.NSED_03745 9.682e-106 346.0 COG2047@1|root,arCOG00348@2157|Archaea,41SFT@651137|Thaumarchaeota 651137|Thaumarchaeota S PAC2 family - - - ko:K07159 - - - - ko00000 - - - PAC2 CMS1_k127_2849760_1 436308.Nmar_1084 2.897e-82 275.0 COG1407@1|root,arCOG01150@2157|Archaea,41SJB@651137|Thaumarchaeota 651137|Thaumarchaeota S Calcineurin-like phosphoesterase - - - ko:K06953 - - - - ko00000 - - - Metallophos CMS1_k127_2849760_0 436308.Nmar_1085 2.218e-267 826.0 COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota 651137|Thaumarchaeota E MGS-like domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS CMS1_k127_2855407_3 1229909.NSED_09100 7.894e-55 194.0 arCOG03681@1|root,arCOG03681@2157|Archaea,41T6V@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2855407_0 436308.Nmar_1709 3.189e-247 771.0 COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota 651137|Thaumarchaeota S ABC1 family - - - - - - - - - - - - ABC1 CMS1_k127_2855407_4 436308.Nmar_1708 3.433e-45 166.0 COG0071@1|root,arCOG01832@2157|Archaea,41T74@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - - - - - - - - - - HSP20 CMS1_k127_2855407_2 436308.Nmar_1707 6.233e-93 308.0 COG0125@1|root,arCOG01891@2157|Archaea,41T33@651137|Thaumarchaeota 651137|Thaumarchaeota F thymidylate kinase tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin CMS1_k127_2855407_1 436308.Nmar_1706 2.454e-186 585.0 COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD CMS1_k127_2900275_0 436308.Nmar_0219 2.198e-99 331.0 arCOG08635@1|root,arCOG08635@2157|Archaea,41T54@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2900275_3 1229909.NSED_00925 3.358e-32 124.0 COG2126@1|root,arCOG04126@2157|Archaea,41T9V@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl37e - - ko:K02922 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L37e CMS1_k127_2900275_2 1229909.NSED_00930 5.462e-37 139.0 COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota 651137|Thaumarchaeota K snRNP Sm proteins - - - ko:K04796 - - - - ko00000 - - - LSM CMS1_k127_2900275_1 436308.Nmar_0222 4.281e-65 224.0 COG1402@1|root,arCOG04536@2157|Archaea,41SNC@651137|Thaumarchaeota 651137|Thaumarchaeota H Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS1_k127_293281_3 436308.Nmar_0800 5.259e-77 258.0 COG0093@1|root,arCOG04095@2157|Archaea,41SHG@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rpl14 - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 CMS1_k127_293281_5 1229909.NSED_04435 9.051e-52 187.0 COG0198@1|root,arCOG04094@2157|Archaea,41SSS@651137|Thaumarchaeota 651137|Thaumarchaeota J Located at the polypeptide exit tunnel on the outside of the subunit rpl24 - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L26 CMS1_k127_293281_0 436308.Nmar_0798 1.089e-121 393.0 COG1471@1|root,arCOG04093@2157|Archaea,41SIE@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS4 family rps4e - - ko:K02987 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - RS4NT,Ribosomal_S4e,S4 CMS1_k127_293281_1 436308.Nmar_0797 2.97e-86 287.0 COG0094@1|root,arCOG04092@2157|Archaea,41SJP@651137|Thaumarchaeota 651137|Thaumarchaeota J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rpl5 - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C CMS1_k127_293281_8 436308.Nmar_0796 3.082e-32 126.0 COG0199@1|root,arCOG00782@2157|Archaea,41SW8@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein S14 rps14 - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 CMS1_k127_293281_2 436308.Nmar_0794 1.057e-84 283.0 COG0097@1|root,arCOG04090@2157|Archaea,41SJG@651137|Thaumarchaeota 651137|Thaumarchaeota J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rpl6 - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 CMS1_k127_293281_6 436308.Nmar_0793 1.124e-45 166.0 arCOG08710@1|root,arCOG08710@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_293281_7 436308.Nmar_0792 4.091e-42 155.0 arCOG08711@1|root,arCOG08711@2157|Archaea,41T4I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_293281_9 1229909.NSED_04395 1.173e-27 113.0 arCOG11516@1|root,arCOG11516@2157|Archaea,41T9Y@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_293281_4 1229909.NSED_04390 2.833e-67 231.0 COG5440@1|root,arCOG01713@2157|Archaea 2157|Archaea S conserved protein (DUF2299) - - - - - - - - - - - - DUF2299 CMS1_k127_2939263_4 436308.Nmar_1500 4.155e-95 311.0 arCOG08676@1|root,arCOG08676@2157|Archaea,41SCF@651137|Thaumarchaeota 651137|Thaumarchaeota C Archaeal ammonia monooxygenase subunit A (AmoA) - - 1.14.18.3,1.14.99.39 ko:K10944 ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200 M00174,M00528,M00804 R00148,R09518 RC00173,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Archaeal_AmoA CMS1_k127_2939263_0 1229909.NSED_08250 6.287e-148 471.0 COG0338@1|root,arCOG03416@2157|Archaea,41SHH@651137|Thaumarchaeota 651137|Thaumarchaeota L PFAM D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 CMS1_k127_2939263_5 1229909.NSED_08245 3.569e-73 247.0 arCOG08677@1|root,arCOG08677@2157|Archaea,41SVJ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2939263_1 436308.Nmar_1497 2.223e-112 370.0 arCOG03932@1|root,arCOG03932@2157|Archaea,41SKB@651137|Thaumarchaeota 651137|Thaumarchaeota K Cobalamin B12-binding domain protein - - - - - - - - - - - - - CMS1_k127_2939263_3 1229909.NSED_08235 2.752e-95 314.0 COG0526@1|root,arCOG00314@2157|Archaea,41SKE@651137|Thaumarchaeota 651137|Thaumarchaeota O Redoxin - - - - - - - - - - - - AhpC-TSA CMS1_k127_2939263_2 1229909.NSED_08230 7.194e-109 362.0 arCOG08642@1|root,arCOG08642@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_2939263_6 1229909.NSED_08220 5.609e-67 231.0 COG1986@1|root,arCOG01223@2157|Archaea,41SKV@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.3 ko:K02201 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like CMS1_k127_2939263_8 1229909.NSED_08215 5.673e-55 193.0 arCOG08641@1|root,arCOG08641@2157|Archaea,41SU7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2939263_7 436308.Nmar_1492 1.034e-65 231.0 arCOG03272@1|root,arCOG03272@2157|Archaea 436308.Nmar_1492|- - - - - - - - - - - - - - - - CMS1_k127_2939263_9 436308.Nmar_1491 1.747e-14 74.0 arCOG10585@1|root,arCOG10585@2157|Archaea,41SW6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2951323_5 1229909.NSED_01620 1.909e-33 130.0 COG1691@1|root,arCOG02465@2157|Archaea,41SCY@651137|Thaumarchaeota 651137|Thaumarchaeota S AIR carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC CMS1_k127_2951323_1 1229909.NSED_01625 3.425e-174 548.0 COG0039@1|root,arCOG00246@2157|Archaea,41S7Z@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the LDH MDH superfamily - - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N CMS1_k127_2951323_2 1229909.NSED_01630 1.566e-162 521.0 COG1641@1|root,arCOG02701@2157|Archaea,41SDC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function DUF111 - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 CMS1_k127_2951323_4 1131266.ARWQ01000001_gene1169 1.999e-44 164.0 COG1606@1|root,arCOG00043@2157|Archaea,41SF3@651137|Thaumarchaeota 651137|Thaumarchaeota S tRNA methyl transferase - - - ko:K06864 - - - - ko00000 - - - QueC CMS1_k127_2951323_3 436308.Nmar_0340 8.662e-55 194.0 COG1606@1|root,arCOG00043@2157|Archaea,41SF3@651137|Thaumarchaeota 651137|Thaumarchaeota S tRNA methyl transferase - - - ko:K06864 - - - - ko00000 - - - QueC CMS1_k127_2951323_0 436308.Nmar_0341 5.423e-182 575.0 COG1104@1|root,arCOG00066@2157|Archaea,41SB1@651137|Thaumarchaeota 651137|Thaumarchaeota E Cysteine desulfurase - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 CMS1_k127_2968207_0 1304885.AUEY01000014_gene3322 1.93e-71 266.0 COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42SPI@68525|delta/epsilon subdivisions,2WQM8@28221|Deltaproteobacteria,2MKXA@213118|Desulfobacterales 28221|Deltaproteobacteria O Subtilase family - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - B_lectin,Inhibitor_I9,Peptidase_S8,Somatomedin_B CMS1_k127_2968207_1 1042377.AFPJ01000027_gene2670 1.491e-20 107.0 COG3325@1|root,COG3979@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,1MWAR@1224|Proteobacteria,1RPNS@1236|Gammaproteobacteria,4672D@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glyco_18 chiA - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - CBM_5_12,ChitinaseA_N,Glyco_hydro_18,REJ CMS1_k127_2980330_0 436308.Nmar_0444 3.301e-215 670.0 COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota 651137|Thaumarchaeota M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_tranf_2_3 CMS1_k127_2980330_1 436308.Nmar_0443 7.478e-175 551.0 COG1146@1|root,arCOG04548@2157|Archaea,41SH5@651137|Thaumarchaeota 651137|Thaumarchaeota C ferredoxin - - - - - - - - - - - - Fer4 CMS1_k127_2982823_0 436308.Nmar_1035 1.415e-226 704.0 COG1980@1|root,arCOG04180@2157|Archaea,41S67@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) fbp - 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 - - - FBPase_3 CMS1_k127_2982823_1 436308.Nmar_1036 5.859e-07 51.0 arCOG08725@1|root,arCOG08725@2157|Archaea,41T3W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_2983595_2 1229909.NSED_06410 3.106e-51 181.0 COG0178@1|root,arCOG04694@2157|Archaea,41T01@651137|Thaumarchaeota 651137|Thaumarchaeota L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran CMS1_k127_2983595_0 436308.Nmar_1103 1.985e-291 899.0 COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota 651137|Thaumarchaeota L TIGRFAM excinuclease ABC, C subunit - - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,UVR,UvrC_HhH_N CMS1_k127_2983595_1 1229909.NSED_06400 1.452e-206 649.0 COG3794@1|root,arCOG08764@1|root,arCOG02926@2157|Archaea,arCOG08764@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind CMS1_k127_3002228_4 1229909.NSED_00090 8.389e-111 364.0 COG1797@1|root,arCOG00106@2157|Archaea,41SBP@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - CbiA,GATase_3 CMS1_k127_3002228_5 1459636.NTE_01733 2.463e-68 237.0 COG2082@1|root,COG2138@1|root,arCOG02246@2157|Archaea,arCOG02247@2157|Archaea,41SH6@651137|Thaumarchaeota 651137|Thaumarchaeota P Cobalt chelatase (CbiK) - - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiX CMS1_k127_3002228_3 436308.Nmar_0081 5.608e-128 412.0 COG2138@1|root,arCOG02246@2157|Archaea,41SH6@651137|Thaumarchaeota 651137|Thaumarchaeota P Cobalt chelatase (CbiK) - - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiX CMS1_k127_3002228_2 436308.Nmar_0082 1.023e-161 515.0 COG2073@1|root,arCOG00651@2157|Archaea,41S83@651137|Thaumarchaeota 651137|Thaumarchaeota H Cobalamin synthesis G C-terminus - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid CMS1_k127_3002228_0 1229909.NSED_00110 6.041e-184 580.0 COG1903@1|root,arCOG04383@2157|Archaea,41S70@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD CMS1_k127_3002228_6 639282.DEFDS_0565 2.694e-29 128.0 COG0702@1|root,COG0702@2|Bacteria,2GFB1@200930|Deferribacteres 200930|Deferribacteres M NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 CMS1_k127_3002228_1 1229909.NSED_00120 5.151e-172 541.0 COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota 651137|Thaumarchaeota H S-adenosylmethionine synthetase - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N CMS1_k127_3042066_0 1229909.NSED_01295 2.718e-156 494.0 COG0649@1|root,arCOG01548@2157|Archaea,41S62@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the complex I 49 kDa subunit family - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa CMS1_k127_3042066_3 436308.Nmar_0278 1.157e-82 278.0 COG0852@1|root,arCOG01551@2157|Archaea,41SJS@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase 27 kD subunit - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa CMS1_k127_3042066_1 1229909.NSED_01285 3.151e-113 365.0 COG0377@1|root,arCOG01554@2157|Archaea,41S6D@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the complex I 20 kDa subunit family - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 CMS1_k127_3042066_4 1131266.ARWQ01000008_gene338 1.05e-56 200.0 COG0838@1|root,arCOG01557@2157|Archaea,41SMI@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 3 - - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 CMS1_k127_3042066_2 436308.Nmar_0275 7.105e-87 288.0 COG1225@1|root,arCOG00310@2157|Archaea,41SKG@651137|Thaumarchaeota 651137|Thaumarchaeota O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA CMS1_k127_304569_1 436308.Nmar_0727 7.102e-39 153.0 arCOG08797@1|root,arCOG08797@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_304569_0 436308.Nmar_0726 0.0 1014.0 COG0553@1|root,arCOG00883@2157|Archaea,41T0G@651137|Thaumarchaeota 651137|Thaumarchaeota K SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N CMS1_k127_304569_2 1229909.NSED_07455 4.771e-07 55.0 COG1846@1|root,arCOG03748@2157|Archaea 2157|Archaea K RNA secondary structure unwinding - - - - - - - - - - - - HTH_45,MarR_2,TrmB CMS1_k127_3052479_3 436308.Nmar_0301 2.985e-09 57.0 COG0176@1|root,arCOG05061@2157|Archaea,41S99@651137|Thaumarchaeota 651137|Thaumarchaeota G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA CMS1_k127_3052479_2 1229909.NSED_01460 6.014e-40 149.0 arCOG08822@1|root,arCOG08822@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3052479_1 1229909.NSED_09020 5.716e-81 277.0 arCOG10599@1|root,arCOG10599@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - CMS1_k127_3052479_0 436308.Nmar_0303 2.17e-170 539.0 COG0598@1|root,arCOG02265@2157|Archaea,41SZC@651137|Thaumarchaeota 651137|Thaumarchaeota P Mg2 transporter protein - - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA CMS1_k127_3061870_1 436308.Nmar_0642 4.124e-117 382.0 COG0389@1|root,arCOG04582@2157|Archaea,41SDV@651137|Thaumarchaeota 651137|Thaumarchaeota L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis dbh - 2.7.7.7 ko:K04479 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH CMS1_k127_3061870_0 436308.Nmar_0641 1.289e-151 484.0 arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3061870_2 436308.Nmar_0975 4.431e-13 70.0 COG1602@1|root,arCOG04269@2157|Archaea,41S7H@651137|Thaumarchaeota 651137|Thaumarchaeota S Archaeal Nre, N-terminal - - - - - - - - - - - - Nre_C,Nre_N CMS1_k127_3077407_0 436308.Nmar_1717 2.617e-166 527.0 COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota 651137|Thaumarchaeota P Phosphate uptake regulator - - - - - - - - - - - - PhoU CMS1_k127_3077407_1 436308.Nmar_1716 4.183e-92 304.0 COG0494@1|root,arCOG01073@2157|Archaea,41T73@651137|Thaumarchaeota 651137|Thaumarchaeota L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX CMS1_k127_3077407_2 436308.Nmar_1715 4.286e-11 63.0 COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota 651137|Thaumarchaeota K AsnC-type helix-turn-helix domain - - - - - - - - - - - - HTH_24 CMS1_k127_3087015_0 436308.Nmar_1054 3.458e-129 416.0 COG1855@1|root,arCOG04116@2157|Archaea,41SX0@651137|Thaumarchaeota 651137|Thaumarchaeota S Large family of predicted nucleotide-binding domains - - - ko:K06865 - - - - ko00000 - - - KH_1,T2SSE CMS1_k127_3087015_1 1131266.ARWQ01000002_gene663 1.057e-67 233.0 COG1321@1|root,arCOG02100@2157|Archaea,41SQ9@651137|Thaumarchaeota 651137|Thaumarchaeota K iron dependent repressor - - - - - - - - - - - - Fe_dep_repr_C,Fe_dep_repress CMS1_k127_3087015_2 436308.Nmar_1052 1.327e-52 187.0 arCOG08740@1|root,arCOG08740@2157|Archaea,41T52@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3127716_2 1229909.NSED_09705 2.188e-68 233.0 COG1405@1|root,arCOG01981@2157|Archaea 2157|Archaea K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) tfb - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon CMS1_k127_3127716_4 1229909.NSED_09700 2.988e-27 115.0 COG2433@1|root,arCOG04219@2157|Archaea 2157|Archaea J carbon-nitrogen ligase activity, with glutamine as amido-N-donor - - - - - - - - - - - - - CMS1_k127_3127716_3 1229909.NSED_09695 2e-35 135.0 arCOG11529@1|root,arCOG11529@2157|Archaea,41TAA@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3127716_0 436308.Nmar_0011 0.0 1296.0 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N CMS1_k127_3127716_1 1229909.NSED_09685 1.576e-77 261.0 COG0071@1|root,arCOG01833@2157|Archaea,41SPJ@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS1_k127_313681_0 1229909.NSED_03215 2.494e-136 434.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon CMS1_k127_313681_1 1131266.ARWQ01000006_gene246 1.984e-103 346.0 arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota 651137|Thaumarchaeota E CAAX protease self-immunity - - - - - - - - - - - - Abi CMS1_k127_313681_2 1229909.NSED_03205 3.914e-56 196.0 COG0023@1|root,arCOG04223@2157|Archaea,41SNU@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the SUI1 family - - - ko:K03113 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - SUI1 CMS1_k127_313681_3 436308.Nmar_0621 2.403e-41 154.0 COG1645@1|root,arCOG00578@2157|Archaea,41SVN@651137|Thaumarchaeota 651137|Thaumarchaeota S Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) - - - ko:K07143 - - - - ko00000 - - - Auto_anti-p27 CMS1_k127_3157238_1 436308.Nmar_0550 4.249e-138 443.0 COG0169@1|root,arCOG01033@2157|Archaea,41S6G@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N CMS1_k127_3157238_2 1459636.NTE_01953 1.033e-74 260.0 COG1685@1|root,arCOG01025@2157|Archaea,41SGZ@651137|Thaumarchaeota 651137|Thaumarchaeota E GHMP kinases N terminal domain aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N CMS1_k127_3157238_0 1229909.NSED_02775 4.494e-155 494.0 COG0128@1|root,arCOG04134@2157|Archaea,41S5I@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase CMS1_k127_3159653_4 1229909.NSED_02545 4.886e-06 48.0 COG1418@1|root,arCOG01860@2157|Archaea,41T2N@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06950 - - - - ko00000 - - - HD CMS1_k127_3159653_3 436308.Nmar_0508 1.655e-44 164.0 arCOG08763@1|root,arCOG08763@2157|Archaea,41SWC@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3159653_1 1229909.NSED_02555 8.018e-177 557.0 COG0113@1|root,arCOG04300@2157|Archaea,41SET@651137|Thaumarchaeota 651137|Thaumarchaeota H Delta-aminolevulinic acid dehydratase - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD CMS1_k127_3159653_0 436308.Nmar_0510 2.098e-216 677.0 COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) - - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH CMS1_k127_3159653_2 1229909.NSED_02565 1.007e-65 230.0 COG1648@1|root,arCOG01044@2157|Archaea,41SN9@651137|Thaumarchaeota 651137|Thaumarchaeota H Siroheme synthase - - 1.3.1.76,4.99.1.4 ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_7,Sirohm_synth_M CMS1_k127_3163400_1 436308.Nmar_0408 9.417e-71 243.0 arCOG08670@1|root,arCOG08670@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - DM13 CMS1_k127_3163400_0 1229909.NSED_06535 1.225e-112 374.0 arCOG03042@1|root,arCOG03042@2157|Archaea 2157|Archaea KLT PFAM Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_16,TPR_2,TPR_8 CMS1_k127_3163400_2 1229909.NSED_07295 7.866e-36 138.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - DUF2226,P-II CMS1_k127_3163400_4 1229909.NSED_02930 1.249e-19 92.0 arCOG08754@1|root,arCOG08754@2157|Archaea 1229909.NSED_02930|- - - - - - - - - - - - - - - - CMS1_k127_3163975_5 436308.Nmar_0558 9.465e-17 81.0 arCOG08027@1|root,arCOG08027@2157|Archaea,41T8U@651137|Thaumarchaeota 2157|Archaea D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity - - - ko:K22222 - - - - ko00000,ko04812 - - - - CMS1_k127_3163975_3 1229909.NSED_02820 9.854e-78 260.0 arCOG08652@1|root,arCOG08652@2157|Archaea,41SMZ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3163975_4 1459636.NTE_01710 3.076e-34 132.0 arCOG10521@1|root,arCOG10521@2157|Archaea,41T8A@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3163975_0 1229909.NSED_02815 4.376e-282 870.0 COG0043@1|root,arCOG01671@2157|Archaea,41S94@651137|Thaumarchaeota 651137|Thaumarchaeota H UbiD family decarboxylase - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD CMS1_k127_3163975_1 1229909.NSED_02810 2.48e-219 682.0 COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - - - - - - - - - - - Radical_SAM CMS1_k127_3163975_2 436308.Nmar_0553 3.445e-154 489.0 COG1830@1|root,arCOG04044@2157|Archaea,41SCP@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids aroA' - 2.2.1.10,4.1.2.13 ko:K16306 ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001 R01068,R01070,R02568,R08568 RC00438,RC00439,RC00721,RC02301 ko00000,ko00001,ko00002,ko01000 - - - DeoC CMS1_k127_3168988_1 1229909.NSED_07415 1.975e-150 477.0 COG2159@1|root,arCOG01931@2157|Archaea 2157|Archaea S metal-dependent hydrolase of the TIM-barrel fold - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 CMS1_k127_3168988_0 436308.Nmar_1028 2.473e-205 643.0 COG1250@1|root,arCOG00249@2157|Archaea,41S92@651137|Thaumarchaeota 651137|Thaumarchaeota I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17 ko:K15016 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00374,M00375 R01975,R03026 RC00117,RC00831 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N CMS1_k127_3176959_2 436308.Nmar_0691 7.235e-51 182.0 COG0063@1|root,arCOG00018@2157|Archaea,41S8I@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136 ko:K17758 - - - - ko00000,ko01000 - - - Carb_kinase CMS1_k127_3176959_0 436308.Nmar_0692 5.868e-250 775.0 COG0624@1|root,arCOG01110@2157|Archaea,41SAE@651137|Thaumarchaeota 651137|Thaumarchaeota E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS1_k127_3176959_1 436308.Nmar_0694 6.416e-109 354.0 COG0638@1|root,arCOG00970@2157|Archaea,41SGS@651137|Thaumarchaeota 651137|Thaumarchaeota O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation - - 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome CMS1_k127_3176959_3 251221.35211245 0.0002478 46.0 COG1801@1|root,COG1801@2|Bacteria,1G2CT@1117|Cyanobacteria 1117|Cyanobacteria S COGs COG1801 conserved - - - - - - - - - - - - DUF72 CMS1_k127_3182129_2 1229909.NSED_08345 3.794e-33 129.0 arCOG04405@1|root,arCOG04405@2157|Archaea 2157|Archaea S ASCH domain - - - - - - - - - - - - ASCH CMS1_k127_3182129_1 1121346.KB899850_gene143 6.084e-66 243.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,4H9WH@91061|Bacilli,26QN7@186822|Paenibacillaceae 91061|Bacilli P Rhodanese Homology Domain - - - - - - - - - - - - Lactamase_B,Rhodanese CMS1_k127_3182129_0 1229909.NSED_08335 2.241e-204 640.0 COG2304@1|root,arCOG02900@2157|Archaea,41SDY@651137|Thaumarchaeota 651137|Thaumarchaeota S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - CMS1_k127_3211635_0 1229909.NSED_05350 3.985e-26 113.0 COG0784@1|root,arCOG02391@2157|Archaea 2157|Archaea T response regulator, receiver - - - ko:K03413,ko:K07662,ko:K07667 ko01503,ko02020,ko02024,ko02030,map01503,map02020,map02024,map02030 M00447,M00454,M00506,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CHASE4,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg CMS1_k127_3212175_1 1229909.NSED_03760 2.192e-29 117.0 COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota 651137|Thaumarchaeota P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N CMS1_k127_3212175_0 436308.Nmar_0731 4.06e-34 134.0 arCOG08757@1|root,arCOG08757@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3212175_2 436308.Nmar_0733 1.367e-23 100.0 arCOG07442@1|root,arCOG07442@2157|Archaea,41TA2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3212175_3 1131266.ARWQ01000001_gene1219 1.981e-23 104.0 arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3213665_0 436308.Nmar_0381 2.551e-141 453.0 COG0244@1|root,arCOG04288@2157|Archaea,41S9R@651137|Thaumarchaeota 651137|Thaumarchaeota J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rpl10 - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 CMS1_k127_3213665_1 1131266.ARWQ01000001_gene1150 4.936e-91 303.0 COG2860@1|root,arCOG04641@2157|Archaea,41SIS@651137|Thaumarchaeota 651137|Thaumarchaeota S UPF0126 domain - - - - - - - - - - - - UPF0126 CMS1_k127_3213665_3 436308.Nmar_0374 3.524e-37 142.0 COG2058@1|root,arCOG04287@2157|Archaea,41SP0@651137|Thaumarchaeota 651137|Thaumarchaeota J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rpl12 - - ko:K02869 ko03010,map03010 M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_60s CMS1_k127_3213665_2 436308.Nmar_0373 7.387e-87 289.0 arCOG08745@1|root,arCOG08745@2157|Archaea,41SU1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3216427_0 1229909.NSED_06215 1.307e-137 441.0 COG0444@1|root,arCOG00181@2157|Archaea,41S9V@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY CMS1_k127_3216427_1 436308.Nmar_1065 3.262e-87 290.0 COG0195@1|root,arCOG01761@2157|Archaea,41T4Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcription elongation factor - - - - - - - - - - - - - CMS1_k127_3216427_2 436308.Nmar_1066 7.709e-16 77.0 COG0017@1|root,arCOG00406@2157|Archaea,41S93@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - - - - - - - - - - tRNA-synt_2,tRNA_anti-codon CMS1_k127_3219387_10 436308.Nmar_1648 0.0002103 45.0 arCOG08793@1|root,arCOG08793@2157|Archaea,41TBC@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3219387_2 436308.Nmar_1325 2.316e-192 611.0 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA CMS1_k127_3219387_9 1089547.KB913013_gene710 0.0001071 44.0 2CFT1@1|root,32WXV@2|Bacteria,4NTST@976|Bacteroidetes,47X5U@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_3219387_4 436308.Nmar_0090 1.28e-156 498.0 COG1131@1|root,arCOG00194@2157|Archaea,41TB8@651137|Thaumarchaeota 651137|Thaumarchaeota E AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS1_k127_3219387_7 273116.14325632 1.835e-34 141.0 COG0842@1|root,arCOG01467@2157|Archaea,2XT3B@28890|Euryarchaeota,2429G@183967|Thermoplasmata 183967|Thermoplasmata V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane CMS1_k127_3219387_1 1229909.NSED_00170 3.025e-219 683.0 COG0677@1|root,arCOG00252@2157|Archaea,41S8F@651137|Thaumarchaeota 651137|Thaumarchaeota M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - - - - - - - - - - - CMS1_k127_3219387_5 1229909.NSED_00175 3.482e-64 225.0 COG0576@1|root,arCOG04772@2157|Archaea,41SSU@651137|Thaumarchaeota 651137|Thaumarchaeota O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ - - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE CMS1_k127_3219387_0 436308.Nmar_0096 0.0 1028.0 COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota 651137|Thaumarchaeota O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 CMS1_k127_3219387_3 436308.Nmar_0097 1.665e-186 587.0 COG0484@1|root,arCOG02846@2157|Archaea,41SCZ@651137|Thaumarchaeota 651137|Thaumarchaeota O DnaJ central domain - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG CMS1_k127_3219387_8 1229909.NSED_00195 5.858e-18 83.0 arCOG10416@1|root,arCOG10416@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3219387_6 436308.Nmar_0099 8.471e-60 209.0 COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatE - 6.3.5.7 ko:K03330 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - GAD,GatB_N,GatB_Yqey CMS1_k127_3240192_1 436308.Nmar_1605 5.613e-145 463.0 COG2262@1|root,arCOG00353@2157|Archaea,41SD4@651137|Thaumarchaeota 651137|Thaumarchaeota S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 CMS1_k127_3240192_0 436308.Nmar_1604 3.122e-187 588.0 COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota 651137|Thaumarchaeota K Phosphate uptake regulator - - - - - - - - - - - - MazE_antitoxin,PhoU CMS1_k127_3240192_2 436308.Nmar_1603 5.128e-68 234.0 COG1370@1|root,arCOG00991@2157|Archaea,41SP1@651137|Thaumarchaeota 651137|Thaumarchaeota O Patch-forming domain C2 of tRNA-guanine transglycosylase - - - ko:K07398 - - - - ko00000 - - - PUA,TGT_C2 CMS1_k127_3240192_3 1229909.NSED_08675 2.049e-54 192.0 COG1308@1|root,arCOG04061@2157|Archaea,41SNN@651137|Thaumarchaeota 651137|Thaumarchaeota K Contacts the emerging nascent chain on the ribosome nac - - ko:K03626 - - - - ko00000 - - - NAC CMS1_k127_3240192_4 436308.Nmar_1601 4.035e-41 154.0 COG2811@1|root,arCOG03363@2157|Archaea,41TA7@651137|Thaumarchaeota 651137|Thaumarchaeota C H subunit - - - ko:K02107 ko00190,map00190 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - - CMS1_k127_3240192_5 436308.Nmar_1600 9.461e-11 62.0 arCOG03142@1|root,arCOG03142@2157|Archaea,41T78@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3240544_2 1229909.NSED_00730 6.472e-97 318.0 COG0131@1|root,arCOG04398@2157|Archaea,41SGY@651137|Thaumarchaeota 651137|Thaumarchaeota E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD CMS1_k127_3240544_1 1229909.NSED_00735 1.43e-102 336.0 COG0118@1|root,arCOG00089@2157|Archaea,41SY2@651137|Thaumarchaeota 651137|Thaumarchaeota E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase CMS1_k127_3240544_0 1229909.NSED_00740 5.329e-116 376.0 COG0106@1|root,arCOG00618@2157|Archaea,41SIG@651137|Thaumarchaeota 651137|Thaumarchaeota E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth CMS1_k127_3240544_3 1229909.NSED_00745 2.602e-68 233.0 COG0107@1|root,arCOG00617@2157|Archaea,41S9A@651137|Thaumarchaeota 651137|Thaumarchaeota E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth CMS1_k127_3251233_1 1229909.NSED_08530 2.137e-71 243.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5 CMS1_k127_3251233_0 1229909.NSED_08515 1.247e-136 439.0 COG0463@1|root,arCOG00894@2157|Archaea,41T1Z@651137|Thaumarchaeota 651137|Thaumarchaeota M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 CMS1_k127_3251233_2 1123400.KB904755_gene2577 1.008e-23 115.0 COG2931@1|root,COG5184@1|root,COG2931@2|Bacteria,COG5184@2|Bacteria,1QVVC@1224|Proteobacteria,1T2K2@1236|Gammaproteobacteria 1236|Gammaproteobacteria DZ regulator of chromosome condensation, RCC1 - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - DUF1566 CMS1_k127_3261981_2 1229909.NSED_07140 3.146e-129 414.0 COG0137@1|root,arCOG00112@2157|Archaea,41S6K@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth CMS1_k127_3261981_4 436308.Nmar_1287 3.162e-27 111.0 arCOG01588@1|root,arCOG01588@2157|Archaea,41SVX@651137|Thaumarchaeota 651137|Thaumarchaeota E lysine biosynthesis protein LysW - - - ko:K05826 - M00031,M00763 - - ko00000,ko00001,ko00002 - - - - CMS1_k127_3261981_1 1229909.NSED_07150 5.156e-156 496.0 COG0189@1|root,arCOG01589@2157|Archaea,41SCQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK CMS1_k127_3261981_0 1229909.NSED_07155 3.641e-224 696.0 COG0002@1|root,arCOG00495@2157|Archaea,41S8R@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily lysY - - ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230 M00031,M00763 R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC CMS1_k127_3261981_3 436308.Nmar_1290 7.126e-84 280.0 COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) lysZ - - ko:K05828 ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230 M00031,M00763 R09776,R10930 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase CMS1_k127_3268185_0 436308.Nmar_1794 1.135e-316 975.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 CMS1_k127_3268185_1 1229909.NSED_09600 8.677e-270 833.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT CMS1_k127_3268185_2 1229909.NSED_09595 2.162e-89 298.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 CMS1_k127_3268185_3 436308.Nmar_1792 1.127e-22 97.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 CMS1_k127_3286140_3 436308.Nmar_0053 4.342e-49 175.0 COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 CMS1_k127_3286140_1 436308.Nmar_0052 7.348e-111 361.0 COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD CMS1_k127_3286140_0 1229909.NSED_09875 4.896e-224 696.0 COG2046@1|root,arCOG04191@2157|Archaea,41SER@651137|Thaumarchaeota 651137|Thaumarchaeota P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 CMS1_k127_3286140_2 1229909.NSED_09870 1.551e-101 333.0 COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota 651137|Thaumarchaeota E Phosphoadenosine phosphosulfate reductase family - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct CMS1_k127_3301169_5 436308.Nmar_1763 3.149e-53 189.0 COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 CMS1_k127_3301169_6 436308.Nmar_1764 6.42e-48 179.0 arCOG08028@1|root,arCOG08028@2157|Archaea,41SWE@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3301169_4 436308.Nmar_1765 3.176e-65 223.0 COG1145@1|root,arCOG00291@2157|Archaea 2157|Archaea C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - 1.8.4.10,1.8.4.8 ko:K00390,ko:K05337 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_10,Fer4_7 CMS1_k127_3301169_2 1229909.NSED_09425 3.875e-164 522.0 COG3794@1|root,arCOG08795@1|root,arCOG02926@2157|Archaea,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1 CMS1_k127_3301169_7 1229909.NSED_07625 5.12e-19 90.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - DUF2226,P-II CMS1_k127_3301169_0 1229909.NSED_09430 7.191e-197 629.0 arCOG02322@1|root,arCOG07810@1|root,arCOG02322@2157|Archaea,arCOG07810@2157|Archaea,41T0S@651137|Thaumarchaeota 651137|Thaumarchaeota N Adenylate guanylate cyclase with integral membrane sensor - - - - - - - - - - - - Guanylate_cyc,HAMP CMS1_k127_3301169_1 436308.Nmar_1767 1.31e-184 582.0 COG0484@1|root,arCOG02846@2157|Archaea,41T1F@651137|Thaumarchaeota 651137|Thaumarchaeota O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ CMS1_k127_3301169_3 436308.Nmar_1768 6.044e-72 244.0 COG0589@1|root,arCOG02053@2157|Archaea,41T7V@651137|Thaumarchaeota 651137|Thaumarchaeota T Universal stress protein - - - - - - - - - - - - Usp CMS1_k127_3313140_1 1229909.NSED_00215 2.468e-65 228.0 COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N CMS1_k127_3313140_0 1229909.NSED_06055 7.295e-114 376.0 COG3391@1|root,arCOG02562@2157|Archaea,41T9S@651137|Thaumarchaeota 651137|Thaumarchaeota S TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Lactonase CMS1_k127_3313140_2 1279017.AQYJ01000024_gene1153 4.895e-10 61.0 COG3070@1|root,COG3070@2|Bacteria,1NAYG@1224|Proteobacteria,1SDXZ@1236|Gammaproteobacteria,46BQS@72275|Alteromonadaceae 1236|Gammaproteobacteria K TfoX N-terminal domain - - - - - - - - - - - - TfoX_N CMS1_k127_3316259_3 1229909.NSED_08185 4.552e-65 223.0 COG2947@1|root,arCOG08640@2157|Archaea,41SK6@651137|Thaumarchaeota 651137|Thaumarchaeota S EVE domain - - - - - - - - - - - - EVE CMS1_k127_3316259_4 1229909.NSED_04345 2.957e-24 103.0 arCOG11733@1|root,arCOG11733@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3316259_0 436308.Nmar_1488 1.054e-263 820.0 COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota 651137|Thaumarchaeota J phenylalanyl-tRNA synthetase, beta subunit - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5 CMS1_k127_3316259_2 589924.Ferp_1742 9.694e-94 324.0 COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,245SE@183980|Archaeoglobi 183980|Archaeoglobi J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2d CMS1_k127_3316259_1 436308.Nmar_1490 3.677e-224 696.0 COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b CMS1_k127_3316259_5 436308.Nmar_1491 3.261e-16 79.0 arCOG10585@1|root,arCOG10585@2157|Archaea,41SW6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3320206_0 436308.Nmar_1097 7.776e-47 172.0 COG2259@1|root,arCOG08092@2157|Archaea 2157|Archaea S DoxX family - - 1.8.5.2 ko:K15977,ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - DoxX CMS1_k127_3328366_1 436308.Nmar_0333 3.918e-12 77.0 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3328839_1 1229909.NSED_08490 2.288e-222 702.0 COG1404@1|root,arCOG00704@2157|Archaea,41SEM@651137|Thaumarchaeota 651137|Thaumarchaeota O Subtilase family - - - - - - - - - - - - Peptidase_S8 CMS1_k127_3328839_2 1123386.AUIW01000004_gene807 9.586e-07 58.0 COG0723@1|root,COG0723@2|Bacteria,1WJBT@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C PFAM Rieske 2Fe-2S domain - - - ko:K15878 - - - - ko00000 - - - Rieske CMS1_k127_3328839_0 1229909.NSED_08480 1.171e-227 706.0 COG1290@1|root,arCOG01721@2157|Archaea,41SDA@651137|Thaumarchaeota 651137|Thaumarchaeota C Cytochrome b subunit of the bc complex - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B CMS1_k127_3356219_1 1297742.A176_05132 1.001e-17 94.0 COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3 CMS1_k127_3356219_2 1353528.DT23_16980 1.293e-14 84.0 COG4922@1|root,COG4922@2|Bacteria,1RDM5@1224|Proteobacteria,2UG54@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - SnoaL,SnoaL_2 CMS1_k127_3356219_0 1229909.NSED_03000 3.709e-91 302.0 COG1528@1|root,arCOG01095@2157|Archaea 2157|Archaea P PFAM Ferritin, Dps family protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin CMS1_k127_3359972_3 436308.Nmar_0593 8.858e-33 128.0 COG1060@1|root,arCOG00657@2157|Archaea,41S95@651137|Thaumarchaeota 651137|Thaumarchaeota H Radical SAM - - 2.5.1.77 ko:K11780 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM CMS1_k127_3359972_0 436308.Nmar_0594 5.091e-190 598.0 COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota 651137|Thaumarchaeota O Trypsin-like serine protease with C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Trypsin_2 CMS1_k127_3359972_1 436308.Nmar_0595 1.171e-185 589.0 COG1215@1|root,arCOG01389@2157|Archaea 2157|Archaea M PFAM Glycosyl transferase family 2 - - - ko:K07011,ko:K11936 ko02026,map02026 - - - ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.2,4.D.1.1.3 GT2 - Glyco_tranf_2_3,Glycos_transf_2 CMS1_k127_3359972_2 1229909.NSED_03115 3.464e-54 195.0 arCOG05400@1|root,arCOG05400@2157|Archaea,41SQH@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 CMS1_k127_3360134_8 436308.Nmar_1178 7.594e-30 121.0 arCOG11736@1|root,arCOG11736@2157|Archaea,41T70@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3360134_1 1229909.NSED_06590 2.046e-140 455.0 arCOG08686@1|root,arCOG08686@2157|Archaea,41T56@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3360134_3 436308.Nmar_1180 9.709e-105 341.0 COG1945@1|root,arCOG04490@2157|Archaea,41SPZ@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the PdaD family pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC CMS1_k127_3360134_2 436308.Nmar_1181 4.866e-109 360.0 COG1651@1|root,arCOG02868@2157|Archaea 2157|Archaea O COG1651 Protein-disulfide isomerase - - - ko:K21990 - - - - ko00000 1.A.16.4 - - Form_Nir_trans,Thioredoxin_4 CMS1_k127_3360134_0 436308.Nmar_1182 2.707e-239 744.0 COG0513@1|root,arCOG00558@2157|Archaea,41SM1@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C CMS1_k127_3360134_7 1229909.NSED_06615 6.74e-36 137.0 COG1522@1|root,arCOG01117@2157|Archaea,41T6G@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg CMS1_k127_3360134_4 1229909.NSED_03715 1.357e-54 192.0 arCOG03272@1|root,arCOG03272@2157|Archaea,41T3V@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3360134_6 1229909.NSED_06755 1.988e-36 139.0 arCOG08688@1|root,arCOG08688@2157|Archaea,41T55@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3360134_5 436308.Nmar_1185 6.574e-53 191.0 arCOG08689@1|root,arCOG08689@2157|Archaea,41T5U@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3370461_2 1229909.NSED_02205 1.284e-111 364.0 COG1208@1|root,arCOG00663@2157|Archaea 2157|Archaea M PFAM Nucleotidyl transferase - - 2.6.1.37,2.7.7.13 ko:K00966,ko:K03430 ko00051,ko00440,ko00520,ko01100,ko01110,ko01120,map00051,map00440,map00520,map01100,map01110,map01120 M00114,M00361,M00362 R00885,R04152 RC00002,RC00008,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - NTP_transferase CMS1_k127_3370461_4 345219.Bcoa_2061 1.335e-69 241.0 COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,4HFTY@91061|Bacilli,1ZAVC@1386|Bacillus 91061|Bacilli E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C CMS1_k127_3370461_1 1229909.NSED_02195 6.865e-245 759.0 COG0065@1|root,arCOG01698@2157|Archaea,41SYT@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, large subunit - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase CMS1_k127_3370461_5 1229909.NSED_02195 1.197e-22 97.0 COG0065@1|root,arCOG01698@2157|Archaea,41SYT@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, large subunit - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase CMS1_k127_3370461_3 436308.Nmar_0421 2.165e-91 301.0 COG0066@1|root,arCOG02230@2157|Archaea,41SIA@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, small subunit - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C CMS1_k127_3370461_0 1229909.NSED_02185 1.575e-251 779.0 COG0065@1|root,arCOG01698@2157|Archaea,41S7A@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase CMS1_k127_3378034_0 1229909.NSED_00030 0.0 1392.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 CMS1_k127_3378034_1 1229909.NSED_00035 5.43e-49 177.0 COG0518@1|root,arCOG00087@2157|Archaea,41SQR@651137|Thaumarchaeota 651137|Thaumarchaeota F glutamine amidotransferase - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase CMS1_k127_3383812_3 1229909.NSED_08555 3.872e-26 118.0 arCOG08793@1|root,arCOG08793@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3383812_1 1229909.NSED_05300 8.866e-111 366.0 COG1378@1|root,arCOG02038@2157|Archaea 2157|Archaea K transcriptional - - - - - - - - - - - - Regulator_TrmB,TrmB CMS1_k127_3383812_0 1229909.NSED_02835 3.37e-127 409.0 COG0580@1|root,arCOG04431@2157|Archaea,41S5R@651137|Thaumarchaeota 651137|Thaumarchaeota G Major Intrinsic Protein - - - ko:K06188,ko:K09866 ko04962,ko04976,map04962,map04976 - - - ko00000,ko00001,ko02000 1.A.8 - - MIP CMS1_k127_3383812_2 1229909.NSED_02830 1.021e-86 287.0 COG1225@1|root,arCOG00310@2157|Archaea,41SN5@651137|Thaumarchaeota 651137|Thaumarchaeota O AhpC/TSA antioxidant enzyme - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA CMS1_k127_3383812_4 436308.Nmar_0559 2.733e-20 94.0 arCOG08027@1|root,arCOG08027@2157|Archaea,41T8U@651137|Thaumarchaeota 651137|Thaumarchaeota D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity - - - - - - - - - - - - - CMS1_k127_3387542_5 1229909.NSED_09930 2.869e-14 74.0 COG1794@1|root,arCOG02005@2157|Archaea,41SM4@651137|Thaumarchaeota 651137|Thaumarchaeota M Asp/Glu/Hydantoin racemase - - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race CMS1_k127_3387542_1 436308.Nmar_0059 3.01e-137 439.0 COG2875@1|root,arCOG00645@2157|Archaea,41SE7@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase CMS1_k127_3387542_4 635013.TherJR_1568 2.04e-41 162.0 COG2243@1|root,COG2243@2|Bacteria,1TP87@1239|Firmicutes,249DM@186801|Clostridia,261MY@186807|Peptococcaceae 186801|Clostridia H Precorrin-2 C20-methyltransferase cobI - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase CMS1_k127_3387542_2 1229909.NSED_09915 1.408e-94 312.0 COG2242@1|root,arCOG00977@2157|Archaea,41SID@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 cbiT - 2.1.1.196 ko:K02191 ko00860,map00860 - R05813,R07774 RC00003,RC02052,RC02054 ko00000,ko00001,ko01000 - - - Methyltransf_31 CMS1_k127_3387542_3 436308.Nmar_0056 3.172e-60 212.0 arCOG02206@1|root,arCOG02206@2157|Archaea 2157|Archaea S ribosomal small subunit binding - - - - - - - - - - - - - CMS1_k127_3387542_0 1229909.NSED_09905 4.679e-165 524.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA CMS1_k127_3390895_2 436308.Nmar_0345 8.475e-18 83.0 arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_3390895_0 1229909.NSED_03070 7.956e-134 433.0 COG1253@1|root,arCOG00626@2157|Archaea 2157|Archaea S COG1253 Hemolysins and related proteins containing CBS domains cbs9 - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 CMS1_k127_3390895_1 1229909.NSED_04180 8.156e-39 155.0 COG3794@1|root,arCOG02926@2157|Archaea,41T8E@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Copper binding proteins, plastocyanin azurin family - - - - - - - - - - - - Copper-bind CMS1_k127_3405829_4 1459636.NTE_02793 1.466e-33 134.0 COG2019@1|root,arCOG01039@2157|Archaea,41SK7@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the archaeal adenylate kinase family adkA - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AAA_17 CMS1_k127_3405829_0 436308.Nmar_0402 2.801e-283 873.0 COG5253@1|root,arCOG04169@2157|Archaea,41S9X@651137|Thaumarchaeota 651137|Thaumarchaeota U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - Plug_translocon,SecY CMS1_k127_3405829_3 436308.Nmar_0401 7.837e-69 235.0 COG0200@1|root,arCOG00779@2157|Archaea,41SQY@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl15 - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A CMS1_k127_3405829_1 1229909.NSED_01935 1.097e-80 270.0 COG1841@1|root,arCOG04086@2157|Archaea,41SMX@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 CMS1_k127_3405829_2 436308.Nmar_0399 1.29e-73 248.0 COG0098@1|root,arCOG04087@2157|Archaea,41SFS@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the universal ribosomal protein uS5 family - - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C CMS1_k127_341623_4 1229909.NSED_08115 1.501e-32 130.0 arCOG08684@1|root,arCOG08684@2157|Archaea,41T64@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_341623_6 436308.Nmar_1595 1.03e-12 73.0 arCOG10592@1|root,arCOG10594@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_341623_1 762376.AXYL_04336 7.493e-50 181.0 COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,2VS3X@28216|Betaproteobacteria,3T45E@506|Alcaligenaceae 28216|Betaproteobacteria S Glyoxalase bleomycin resistance protein dioxygenase superfamily protein 19 - - - - - - - - - - - - Glyoxalase CMS1_k127_341623_3 1229909.NSED_01025 1.416e-35 148.0 COG1340@1|root,arCOG08038@1|root,arCOG01159@2157|Archaea,arCOG08038@2157|Archaea 2157|Archaea S protein secretion by the type IV secretion system - - - - - - - - - - - - MMPL CMS1_k127_341623_2 436308.Nmar_0693 1.019e-45 168.0 COG2259@1|root,arCOG08092@2157|Archaea 2157|Archaea S DoxX family - - 1.8.5.2 ko:K15977,ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - DoxX CMS1_k127_341623_0 1229909.NSED_02970 3.33e-125 409.0 COG0412@1|root,arCOG10350@1|root,arCOG01659@2157|Archaea,arCOG10350@2157|Archaea,41T1E@651137|Thaumarchaeota 651137|Thaumarchaeota Q Chlorophyllase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH CMS1_k127_341623_5 1229909.NSED_06670 3.841e-21 97.0 arCOG08757@1|root,arCOG08757@2157|Archaea 1229909.NSED_06670|- - - - - - - - - - - - - - - - CMS1_k127_341623_8 1229909.NSED_02670 2.178e-06 49.0 COG2102@1|root,arCOG00035@2157|Archaea,41SHD@651137|Thaumarchaeota 651137|Thaumarchaeota S Diphthamide synthase - - 6.3.1.14 ko:K06927 - - R03613 RC00358 ko00000,ko01000,ko03012 - - - Diphthami_syn_2 CMS1_k127_3433204_0 436308.Nmar_0088 0.0 1521.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C CMS1_k127_3433204_1 1229909.NSED_00145 1.191e-242 755.0 COG1599@1|root,arCOG01510@2157|Archaea,41S9M@651137|Thaumarchaeota 651137|Thaumarchaeota L COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins - - - ko:K07466 ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460 M00288 - - ko00000,ko00001,ko00002,ko03000,ko03032,ko03400 - - - - CMS1_k127_3475858_2 436308.Nmar_0007 2.789e-55 196.0 COG0652@1|root,arCOG04767@2157|Archaea,41T0W@651137|Thaumarchaeota 651137|Thaumarchaeota O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase CMS1_k127_3475858_0 436308.Nmar_0008 5.545e-224 701.0 COG1252@1|root,arCOG01067@2157|Archaea 2157|Archaea C COG1252 NADH dehydrogenase, FAD-containing subunit ndh2 - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_3475858_1 1229909.NSED_09680 7.22e-70 238.0 arCOG01806@1|root,arCOG01806@2157|Archaea,41T2B@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3482327_3 1229909.NSED_04760 1.168e-20 93.0 COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional - - - - - - - - - - - - TrmB CMS1_k127_3482327_1 1229909.NSED_04755 5.2e-73 255.0 COG0467@1|root,arCOG01171@2157|Archaea,41TA0@651137|Thaumarchaeota 651137|Thaumarchaeota T KaiC - - - ko:K08482 - - - - ko00000 - - - ATPase CMS1_k127_3482327_0 436308.Nmar_0863 1.748e-201 633.0 COG1915@1|root,arCOG04422@2157|Archaea,41SBQ@651137|Thaumarchaeota 651137|Thaumarchaeota S LOR SDH bifunctional - - - - - - - - - - - - Saccharop_dh_N CMS1_k127_3482327_2 436308.Nmar_0862 1.086e-51 184.0 arCOG08655@1|root,arCOG08655@2157|Archaea,41SR9@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3484216_2 1229909.NSED_03730 1.254e-40 153.0 arCOG11724@1|root,arCOG11724@2157|Archaea 2157|Archaea S Arsenate reductase and related - - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC CMS1_k127_3484216_0 1229909.NSED_03725 7.865e-42 154.0 arCOG10537@1|root,arCOG10537@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3484268_2 1229909.NSED_00840 1.092e-23 111.0 arCOG10597@1|root,arCOG10597@2157|Archaea 1229909.NSED_00840|- O serine-type endopeptidase activity - - - - - - - - - - - - - CMS1_k127_3484268_0 436308.Nmar_0409 7.272e-224 699.0 COG0579@1|root,arCOG00754@2157|Archaea,41SXA@651137|Thaumarchaeota 651137|Thaumarchaeota S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO CMS1_k127_3484268_1 1229909.NSED_02130 1.954e-38 145.0 arCOG08666@1|root,arCOG08666@2157|Archaea,41SVR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_352697_4 436308.Nmar_1409 2.382e-27 111.0 COG1094@1|root,arCOG04150@2157|Archaea,41SNG@651137|Thaumarchaeota 651137|Thaumarchaeota J K homology RNA-binding domain - - - ko:K06961 - - - - ko00000,ko03009 - - - KH_1 CMS1_k127_352697_0 1229909.NSED_07745 1.909e-128 414.0 COG1718@1|root,arCOG01180@2157|Archaea,41T2X@651137|Thaumarchaeota 651137|Thaumarchaeota T Serine threonine protein kinase involved in cell cycle control - - 2.7.11.1 ko:K07178 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko01001,ko03009 - - - RIO1 CMS1_k127_352697_3 436308.Nmar_1411 2.559e-38 145.0 COG2412@1|root,arCOG04051@2157|Archaea,41SS6@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF424) - - - ko:K09148 - - - - ko00000 - - - DUF424 CMS1_k127_352697_1 436308.Nmar_1412 2.699e-79 265.0 COG1601@1|root,arCOG01640@2157|Archaea,41STZ@651137|Thaumarchaeota 651137|Thaumarchaeota J Translation initiation factor - - - ko:K03238 ko03013,map03013 - - - ko00000,ko00001,ko01009,ko03012 - - - eIF-5_eIF-2B CMS1_k127_352697_5 436308.Nmar_1413 3.462e-24 101.0 arCOG07442@1|root,arCOG07442@2157|Archaea,41SWG@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_352697_2 436308.Nmar_1414 2.269e-52 190.0 arCOG08774@1|root,arCOG08774@2157|Archaea,41T7U@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3540256_1 1229909.NSED_09845 6.192e-83 277.0 COG0300@1|root,arCOG01263@2157|Archaea,41SXQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short CMS1_k127_3540256_2 436308.Nmar_0045 3.889e-58 204.0 arCOG10514@1|root,arCOG10514@2157|Archaea,41STR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3540256_3 436308.Nmar_0046 6.771e-45 164.0 arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3540256_0 436308.Nmar_0047 9.759e-146 466.0 COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota 651137|Thaumarchaeota G Glycosyl transferase family 1 - - - - - - - - - - - - - CMS1_k127_3563261_1 436308.Nmar_0184 8.895e-109 354.0 COG0843@1|root,arCOG01237@2157|Archaea,41S9Z@651137|Thaumarchaeota 651137|Thaumarchaeota C Heme copper-type cytochrome quinol - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 CMS1_k127_3563261_3 436308.Nmar_0183 1.429e-83 278.0 COG1622@1|root,arCOG01236@2157|Archaea,41SMY@651137|Thaumarchaeota 651137|Thaumarchaeota C Heme copper-type cytochrome quinol oxidases, subunit 2 - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 CMS1_k127_3563261_5 436308.Nmar_0182 8.956e-38 143.0 arCOG08824@1|root,arCOG08824@2157|Archaea,41SW7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3563261_2 1229909.NSED_00380 1.142e-104 342.0 COG0406@1|root,arCOG01991@2157|Archaea,41SJM@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoglycerate mutase family - - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 CMS1_k127_3563261_0 1229909.NSED_00375 7.254e-116 376.0 COG2085@1|root,arCOG00457@2157|Archaea,41SH2@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored CMS1_k127_3563261_4 436308.Nmar_0178 2.93e-42 157.0 arCOG00516@1|root,arCOG00516@2157|Archaea,41T43@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate - - - - - - - - - - - - Putative_PNPOx CMS1_k127_356870_1 436308.Nmar_0194 2.133e-148 476.0 COG1819@1|root,arCOG01393@2157|Archaea,41T16@651137|Thaumarchaeota 651137|Thaumarchaeota G Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C CMS1_k127_356870_0 436308.Nmar_0193 1.837e-151 485.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota 651137|Thaumarchaeota E Amino acid kinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase CMS1_k127_3569615_0 1229909.NSED_04950 2.093e-236 735.0 COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota 651137|Thaumarchaeota J Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA prf1 - - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - eRF1_1,eRF1_2,eRF1_3 CMS1_k127_3569615_2 1229909.NSED_04955 5.838e-61 212.0 COG0537@1|root,arCOG00419@2157|Archaea,41SNV@651137|Thaumarchaeota 651137|Thaumarchaeota F HIT domain - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT CMS1_k127_3569615_1 1229909.NSED_04960 2.2e-92 306.0 arCOG10557@1|root,arCOG10557@2157|Archaea,41T1I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3569615_3 436308.Nmar_1329 2.133e-34 142.0 arCOG08796@1|root,arCOG08796@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3589593_1 710696.Intca_0489 2.108e-92 314.0 COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria,4FIKZ@85021|Intrasporangiaceae 201174|Actinobacteria M Peptidase inhibitor I9 - - - - - - - - - - - - Inhibitor_I9,PKD,Peptidase_S8 CMS1_k127_3589593_0 436308.Nmar_1120 0.0 1068.0 COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 CMS1_k127_3603103_0 1229909.NSED_08780 4.241e-174 546.0 COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N CMS1_k127_3603103_1 436308.Nmar_1621 3.09e-126 407.0 COG2301@1|root,arCOG00760@2157|Archaea,41S6F@651137|Thaumarchaeota 651137|Thaumarchaeota G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI CMS1_k127_362690_4 436308.Nmar_1450 2.078e-32 125.0 COG0100@1|root,arCOG04240@2157|Archaea,41SII@651137|Thaumarchaeota 651137|Thaumarchaeota J Located on the platform of the 30S subunit rps11 - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 CMS1_k127_362690_3 1229909.NSED_07975 1.03e-35 138.0 arCOG08729@1|root,arCOG08729@2157|Archaea,41T8R@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_362690_2 436308.Nmar_1452 3.432e-44 164.0 arCOG05529@1|root,arCOG05529@2157|Archaea,41SSJ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - dsDNA_bind CMS1_k127_362690_0 436308.Nmar_1453 9.731e-285 878.0 COG1690@1|root,arCOG04246@2157|Archaea,41SE4@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB CMS1_k127_362690_1 1031288.AXAA01000015_gene303 9.21e-112 372.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae 186801|Clostridia C malic enzyme - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic CMS1_k127_3632650_7 1459636.NTE_00358 4.93e-10 66.0 arCOG12009@1|root,arCOG12009@2157|Archaea 1459636.NTE_00358|- - - - - - - - - - - - - - - - CMS1_k127_3632650_5 436308.Nmar_1467 1.565e-39 154.0 COG1525@1|root,arCOG03192@2157|Archaea 2157|Archaea L COG1525 Micrococcal nuclease (thermonuclease) homologs - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase CMS1_k127_3632650_0 1229909.NSED_01090 4.54e-212 665.0 COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota 651137|Thaumarchaeota J histidyl-tRNA synthetase - - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His CMS1_k127_3632650_4 633148.Tagg_0933 3.354e-43 166.0 COG1976@1|root,arCOG04176@2157|Archaea,2XQJ0@28889|Crenarchaeota 28889|Crenarchaeota J Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex eif6 GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904 - ko:K03264 ko03008,map03008 - - - ko00000,ko00001,ko03009,ko03012 - - - eIF-6 CMS1_k127_3632650_3 436308.Nmar_0238 4.573e-84 280.0 COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 CMS1_k127_3632650_2 1229909.NSED_01105 9.574e-92 304.0 COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 CMS1_k127_3632650_1 436308.Nmar_0240 2.118e-167 531.0 COG0470@1|root,arCOG00469@2157|Archaea,41SFJ@651137|Thaumarchaeota 651137|Thaumarchaeota L Replication factor C - - - ko:K04801 ko03030,map03030 - - - ko00000,ko00001,ko03032 - - - DNA_pol3_delta2,Rep_fac_C,RuvB_N CMS1_k127_3639787_3 436308.Nmar_1227 2.217e-32 128.0 COG1310@1|root,arCOG01138@2157|Archaea,41SSV@651137|Thaumarchaeota 651137|Thaumarchaeota S metal-dependent protease of the PAD1 JAB1 superfamily - - 3.13.1.6 ko:K21140 ko04122,map04122 - R11524 RC00064,RC00090 ko00000,ko00001,ko01000 - - - Prok-JAB CMS1_k127_3639787_2 436308.Nmar_1228 3.785e-47 173.0 COG2164@1|root,arCOG04488@2157|Archaea,41T6P@651137|Thaumarchaeota 651137|Thaumarchaeota S Cyclophilin-like - - - ko:K09143 - - - - ko00000 - - - Cyclophil_like CMS1_k127_3639787_0 436308.Nmar_1357 7.537e-80 271.0 COG0778@1|root,arCOG00288@2157|Archaea,41T1J@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Nitroreductase - - - - - - - - - - - - Nitroreductase CMS1_k127_3639787_1 436308.Nmar_1229 3.749e-49 175.0 arCOG08720@1|root,arCOG08720@2157|Archaea,41STI@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF2024) - - - - - - - - - - - - DUF2024 CMS1_k127_3646833_1 436308.Nmar_0849 5.727e-113 370.0 arCOG08708@1|root,arCOG08708@2157|Archaea,41SPK@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3646833_0 436308.Nmar_0848 8.96e-198 623.0 COG1171@1|root,arCOG01431@2157|Archaea,41SCU@651137|Thaumarchaeota 651137|Thaumarchaeota E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_3678796_3 436308.Nmar_1297 1.829e-162 514.0 COG1798@1|root,COG1849@1|root,arCOG01224@2157|Archaea,arCOG04161@2157|Archaea,41SC2@651137|Thaumarchaeota 651137|Thaumarchaeota H diphthine synthase - - 2.1.1.98 ko:K20215 - - R04481,R08468,R08469,R10306 RC00003,RC00190,RC01155,RC02136,RC02308 ko00000,ko01000 - - - DUF357,TP_methylase CMS1_k127_3678796_1 436308.Nmar_1296 2.096e-208 651.0 COG0624@1|root,arCOG01107@2157|Archaea,41SAX@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine lysK - - ko:K05831 ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230 M00031,M00763 R09779,R10933 RC00064,RC00090 ko00000,ko00001,ko00002 - - - M20_dimer,Peptidase_M20 CMS1_k127_3678796_2 1229909.NSED_07185 4.758e-164 519.0 COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK CMS1_k127_3678796_5 436308.Nmar_1294 3.111e-30 119.0 arCOG01588@1|root,arCOG01588@2157|Archaea,41STK@651137|Thaumarchaeota 651137|Thaumarchaeota E lysine biosynthesis protein LysW - - - ko:K05826 - M00031,M00763 - - ko00000,ko00001,ko00002 - - - - CMS1_k127_3678796_0 436308.Nmar_1293 1.495e-235 732.0 COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota 651137|Thaumarchaeota E HMGL-like - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like CMS1_k127_3678796_4 436308.Nmar_1291 1.506e-109 355.0 COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lysJ - - ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00031,M00763 R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_3709942_5 436308.Nmar_1784 4.341e-21 95.0 arCOG08810@1|root,arCOG08810@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3709942_0 1229909.NSED_09560 4.452e-190 599.0 COG0446@1|root,arCOG01064@2157|Archaea,41SZR@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS1_k127_3709942_1 436308.Nmar_1786 1.108e-121 395.0 COG4221@1|root,arCOG01265@2157|Archaea,41S66@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short CMS1_k127_3709942_4 436308.Nmar_1787 6.635e-35 134.0 COG3582@1|root,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota 651137|Thaumarchaeota S zinc finger - - - - - - - - - - - - zf-AN1 CMS1_k127_3709942_3 436308.Nmar_1788 6.451e-51 181.0 arCOG08809@1|root,arCOG08809@2157|Archaea,41TAB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3709942_2 1229909.NSED_09580 2.131e-55 196.0 COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota 651137|Thaumarchaeota L protein conserved in archaea - - - ko:K09723 - - - - ko00000,ko03032 - - - - CMS1_k127_374393_2 436308.Nmar_1610 9.22e-49 175.0 COG3945@1|root,arCOG01471@2157|Archaea,41T3D@651137|Thaumarchaeota 651137|Thaumarchaeota S Hemerythrin HHE cation binding - - - - - - - - - - - - Hemerythrin CMS1_k127_374393_3 1229909.NSED_08720 9.112e-22 96.0 arCOG10596@1|root,arCOG10596@2157|Archaea,41T8F@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_374393_1 1459636.NTE_03545 1.682e-49 184.0 COG1985@1|root,arCOG01484@2157|Archaea,41SK2@651137|Thaumarchaeota 651137|Thaumarchaeota H RibD C-terminal domain - - 1.1.1.302 ko:K14654 ko00740,ko01100,map00740,map01100 - R09375,R09376 RC00933 ko00000,ko00001,ko01000 - - - RibD_C CMS1_k127_374393_0 436308.Nmar_1613 1.18e-167 532.0 COG0402@1|root,arCOG00692@2157|Archaea,41S61@651137|Thaumarchaeota 651137|Thaumarchaeota F Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS1_k127_3754094_1 436308.Nmar_0206 4.009e-245 760.0 COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18593 ko00720,ko01120,map00720,map01120 - R10758 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig CMS1_k127_3754094_0 436308.Nmar_0207 1.834e-319 980.0 COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota 651137|Thaumarchaeota Q Vinylacetyl-CoA Delta-isomerase - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N CMS1_k127_3754094_3 1229909.NSED_00845 3.599e-85 287.0 COG0681@1|root,arCOG01739@2157|Archaea,41SQ2@651137|Thaumarchaeota 651137|Thaumarchaeota U Signal peptidase - - 3.4.21.89 ko:K13280 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 CMS1_k127_3754094_2 436308.Nmar_0209 2.004e-110 361.0 arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger domain - - - - - - - - - - - - zinc_ribbon_2 CMS1_k127_3754094_5 436308.Nmar_0210 2.436e-61 212.0 COG0526@1|root,arCOG01972@2157|Archaea,41SSR@651137|Thaumarchaeota 651137|Thaumarchaeota O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin CMS1_k127_3754094_4 1229909.NSED_00860 4.994e-80 269.0 arCOG08024@1|root,arCOG08024@2157|Archaea,41SRU@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - zinc_ribbon_2 CMS1_k127_3754094_6 1229909.NSED_00865 5.15e-61 211.0 arCOG08025@1|root,arCOG08025@2157|Archaea,41STV@651137|Thaumarchaeota 651137|Thaumarchaeota S zinc-ribbon domain - - - - - - - - - - - - zinc_ribbon_2 CMS1_k127_3754094_8 1229909.NSED_04815 4.867e-24 105.0 COG0745@1|root,arCOG02595@2157|Archaea,41T9R@651137|Thaumarchaeota 651137|Thaumarchaeota T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS1_k127_3754094_7 1459636.NTE_00852 3.498e-44 180.0 arCOG02363@1|root,arCOG02376@1|root,arCOG02363@2157|Archaea,arCOG02376@2157|Archaea 2157|Archaea T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,HATPase_c,HisKA,MCPsignal,PAS,PAS_9,dCache_1 CMS1_k127_3775710_1 1459636.NTE_03101 1.699e-54 205.0 COG2340@1|root,arCOG03962@2157|Archaea 2157|Archaea S protein with SCP PR1 domains - - - - - - - - - - - - CAP,zf-AN1 CMS1_k127_3775710_0 1459636.NTE_03327 4.021e-113 381.0 arCOG08764@1|root,arCOG08764@2157|Archaea,41TBI@651137|Thaumarchaeota 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3775710_2 1229909.NSED_02870 6.724e-08 56.0 arCOG12097@1|root,arCOG12097@2157|Archaea 1229909.NSED_02870|- - - - - - - - - - - - - - - - CMS1_k127_3782398_0 1229909.NSED_01300 2.386e-174 549.0 COG1005@1|root,arCOG01546@2157|Archaea,41SAT@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH dehydrogenase - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh CMS1_k127_3782398_1 1229909.NSED_01295 3.42e-150 476.0 COG0649@1|root,arCOG01548@2157|Archaea,41S62@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the complex I 49 kDa subunit family - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa CMS1_k127_3802740_1 1131266.ARWQ01000009_gene955 1.983e-40 153.0 COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM Aminotransferase class I and II - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 CMS1_k127_3802740_0 1229909.NSED_00570 7.213e-203 633.0 COG0136@1|root,arCOG00494@2157|Archaea,41SFD@651137|Thaumarchaeota 651137|Thaumarchaeota E aspartate-semialdehyde dehydrogenase - - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC CMS1_k127_380309_2 1229909.NSED_03775 6.665e-10 59.0 arCOG08799@1|root,arCOG08799@2157|Archaea,41T6M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_380309_0 1229909.NSED_05675 4.146e-69 238.0 COG1846@1|root,arCOG03748@2157|Archaea,41T7R@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-binding transcription factor activity - - - - - - - - - - - - - CMS1_k127_380309_1 1047013.AQSP01000132_gene1692 1.452e-26 120.0 COG0451@1|root,COG0451@2|Bacteria,2NPZU@2323|unclassified Bacteria 2|Bacteria M Male sterility protein - - 1.1.1.219,5.1.3.26 ko:K00091,ko:K19997 - - - - ko00000,ko01000 - - - Epimerase CMS1_k127_3809948_2 1229909.NSED_02620 1.924e-93 309.0 COG1386@1|root,arCOG02613@2157|Archaea,41SIC@651137|Thaumarchaeota 651137|Thaumarchaeota K segregation and condensation protein - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB CMS1_k127_3809948_1 1229909.NSED_02625 2.171e-110 360.0 COG1354@1|root,arCOG02610@2157|Archaea,41SMU@651137|Thaumarchaeota 651137|Thaumarchaeota L chromosome segregation and condensation protein ScpA - - - ko:K05896 - - - - ko00000,ko03036 - - - - CMS1_k127_3809948_0 1229909.NSED_02630 2.133e-142 455.0 COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N CMS1_k127_3822405_3 436308.Nmar_0228 6.079e-69 235.0 COG0105@1|root,arCOG04313@2157|Archaea,41SN1@651137|Thaumarchaeota 651137|Thaumarchaeota F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK CMS1_k127_3822405_5 436308.Nmar_0227 1.041e-34 132.0 COG2075@1|root,arCOG01950@2157|Archaea,41T7M@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl24e - - ko:K02896 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L24e CMS1_k127_3822405_6 436308.Nmar_0226 1.682e-31 123.0 COG2053@1|root,arCOG04314@2157|Archaea,41ST6@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS28 family rps28e - - ko:K02979 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S28e CMS1_k127_3822405_2 1229909.NSED_00950 1.435e-71 242.0 COG1358@1|root,arCOG01751@2157|Archaea,41SMS@651137|Thaumarchaeota 651137|Thaumarchaeota J Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs rpl7ae - - ko:K02936 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03009,ko03011 - - - Ribosomal_L7Ae CMS1_k127_3822405_0 436308.Nmar_0224 1.11e-225 706.0 COG1109@1|root,arCOG00767@2157|Archaea,41S74@651137|Thaumarchaeota 651137|Thaumarchaeota G Belongs to the phosphohexose mutase family - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS1_k127_3822405_1 436308.Nmar_0223 3.82e-152 486.0 COG0788@1|root,arCOG02826@2157|Archaea,41S78@651137|Thaumarchaeota 651137|Thaumarchaeota F Formyl transferase - - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT_6,Formyl_trans_N CMS1_k127_3822405_4 1229909.NSED_00935 6.369e-65 225.0 COG1402@1|root,arCOG04536@2157|Archaea,41SNC@651137|Thaumarchaeota 651137|Thaumarchaeota H Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS1_k127_3822706_3 436308.Nmar_0088 8.221e-21 93.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C CMS1_k127_3822706_1 1229909.NSED_00130 4.372e-86 289.0 COG0468@1|root,arCOG00417@2157|Archaea,41SQC@651137|Thaumarchaeota 651137|Thaumarchaeota T RecA RadA - - - ko:K04482,ko:K04483 ko03440,ko03460,ko05200,ko05212,map03440,map03460,map05200,map05212 - - - ko00000,ko00001,ko03400,ko04121,ko04131 - - - Rad51 CMS1_k127_3822706_2 436308.Nmar_0086 1.086e-38 145.0 COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota 651137|Thaumarchaeota K snRNP Sm proteins - - - ko:K04796 - - - - ko00000 - - - LSM CMS1_k127_3822706_0 1229909.NSED_00120 7.147e-146 464.0 COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota 651137|Thaumarchaeota H S-adenosylmethionine synthetase - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N CMS1_k127_3825973_2 436308.Nmar_1390 1.462e-165 522.0 COG0167@1|root,arCOG00603@2157|Archaea 2157|Archaea F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 ko:K00226,ko:K00254,ko:K17723,ko:K17828 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01867,R01868,R01869,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh CMS1_k127_3825973_3 1131266.ARWQ01000004_gene1493 3.263e-127 411.0 COG0543@1|root,arCOG02199@2157|Archaea,41SY5@651137|Thaumarchaeota 651137|Thaumarchaeota H Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,NAD_binding_1 CMS1_k127_3825973_0 436308.Nmar_1388 0.0 1137.0 COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM CMS1_k127_3825973_4 436308.Nmar_1387 1.303e-29 117.0 COG4919@1|root,arCOG04293@2157|Archaea,41SVI@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein S30 - - - ko:K02983 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011,ko04121 - - - Ribosomal_S30 CMS1_k127_3825973_1 1229909.NSED_07545 4.135e-192 606.0 COG0468@1|root,arCOG00415@2157|Archaea,41SBA@651137|Thaumarchaeota 651137|Thaumarchaeota L Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules radA - - ko:K04483 - - - - ko00000,ko03400 - - - HHH_5,Rad51 CMS1_k127_3832070_0 1229909.NSED_01500 4.466e-309 953.0 COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C CMS1_k127_3832070_1 436308.Nmar_0310 2.987e-155 494.0 COG0179@1|root,arCOG00235@2157|Archaea,41S5K@651137|Thaumarchaeota 651137|Thaumarchaeota Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - - - - - - - - - - FAA_hydrolase CMS1_k127_3832070_2 1229909.NSED_01490 1.382e-44 166.0 COG0454@1|root,arCOG00845@2157|Archaea,41T5Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_3843916_1 1229909.NSED_08980 9.335e-102 333.0 COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota 651137|Thaumarchaeota F aspartate carbamoyltransferase pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS1_k127_3843916_2 436308.Nmar_1687 4.567e-87 289.0 COG1781@1|root,arCOG04229@2157|Archaea,41SJT@651137|Thaumarchaeota 651137|Thaumarchaeota F Involved in allosteric regulation of aspartate carbamoyltransferase pyrI - - ko:K00610 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002 - - - PyrI,PyrI_C CMS1_k127_3843916_3 1229909.NSED_08990 8.583e-35 135.0 COG0636@1|root,arCOG06776@2157|Archaea 2157|Archaea C ATP synthase subunit C - - - ko:K02110,ko:K02124 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157,M00159 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1,3.A.2.2,3.A.2.3 - - ATP-synt_C CMS1_k127_3843916_0 436308.Nmar_1689 1.893e-113 368.0 COG1394@1|root,arCOG04101@2157|Archaea,41T0N@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane atpD - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D CMS1_k127_3862576_0 1229909.NSED_00615 5.924e-301 930.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 CMS1_k127_3862576_1 436308.Nmar_1577 9.58e-212 661.0 COG0459@1|root,arCOG01257@2157|Archaea,41T11@651137|Thaumarchaeota 651137|Thaumarchaeota O TCP-1/cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 CMS1_k127_3869604_4 1229909.NSED_03080 8.805e-61 211.0 arCOG10530@1|root,arCOG10530@2157|Archaea,41T2M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3869604_3 436308.Nmar_0583 6.046e-121 391.0 COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota 651137|Thaumarchaeota S PAC2 family - - - ko:K06869 - - - - ko00000 - - - PAC2 CMS1_k127_3869604_2 1229909.NSED_03060 2.188e-181 572.0 COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota 651137|Thaumarchaeota F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS1_k127_3869604_1 1229909.NSED_03055 9.226e-211 660.0 COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger CMS1_k127_3869604_0 436308.Nmar_0579 2.213e-274 849.0 COG1243@1|root,arCOG01361@2157|Archaea,41S9N@651137|Thaumarchaeota 651137|Thaumarchaeota K Histone acetyltransferase - - 2.3.1.48 ko:K07739 - - - - ko00000,ko01000,ko03016,ko03036 - - - Acetyltransf_1,Radical_SAM,Radical_SAM_C CMS1_k127_3882504_0 1459636.NTE_00616 1.658e-82 278.0 COG1704@1|root,arCOG04574@2157|Archaea 2157|Archaea S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA CMS1_k127_3883942_1 1229909.NSED_06830 9.692e-224 704.0 COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota 651137|Thaumarchaeota V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - CMS1_k127_3883942_5 1229909.NSED_06835 6.162e-68 234.0 COG1990@1|root,arCOG04228@2157|Archaea,41ST1@651137|Thaumarchaeota 651137|Thaumarchaeota J Peptidyl-tRNA hydrolase PTH2 - - 3.1.1.29 ko:K04794 - - - - ko00000,ko01000,ko03012 - - - PTH2 CMS1_k127_3883942_2 1229909.NSED_06845 7.917e-189 595.0 COG0644@1|root,arCOG00570@2157|Archaea,41SB5@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - CMS1_k127_3883942_8 1229909.NSED_06850 5.719e-36 136.0 COG2888@1|root,arCOG01989@2157|Archaea,41T83@651137|Thaumarchaeota 651137|Thaumarchaeota J Zn-ribbon RNA-binding protein with a function in translation - - - ko:K07580 - - - - ko00000 - - - - CMS1_k127_3883942_7 436308.Nmar_1222 4.855e-37 141.0 COG2092@1|root,arCOG01988@2157|Archaea,41SS1@651137|Thaumarchaeota 651137|Thaumarchaeota J Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA ef1b - - ko:K03232 - - - - ko00000,ko03012 - - - EF1_GNE CMS1_k127_3883942_0 1229909.NSED_06860 0.0 1307.0 COG0464@1|root,arCOG01308@2157|Archaea,41S7X@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48) domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N CMS1_k127_3883942_6 436308.Nmar_1224 7.431e-40 149.0 arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3883942_3 1229909.NSED_06870 1.094e-154 492.0 COG0109@1|root,arCOG00479@2157|Archaea,41SDQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA CMS1_k127_3883942_4 436308.Nmar_1226 1.239e-86 291.0 COG3794@1|root,arCOG02926@2157|Archaea,arCOG02929@2157|Archaea,41SHN@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind CMS1_k127_3890928_3 436308.Nmar_0415 3.928e-29 116.0 arCOG08664@1|root,arCOG08664@2157|Archaea,41SKM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3890928_2 273057.SSO2816 6.54e-118 387.0 COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota 28889|Crenarchaeota C TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C CMS1_k127_3890928_0 1229909.NSED_02150 0.0 1015.0 COG0674@1|root,arCOG01606@2157|Archaea,41S60@651137|Thaumarchaeota 651137|Thaumarchaeota C pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N CMS1_k127_3890928_1 1229909.NSED_02140 2.622e-156 499.0 COG1052@1|root,arCOG01755@2157|Archaea,41T1D@651137|Thaumarchaeota 651137|Thaumarchaeota C D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C CMS1_k127_3893611_3 1229909.NSED_09460 3.582e-15 79.0 COG0589@1|root,arCOG02053@2157|Archaea,41T7V@651137|Thaumarchaeota 651137|Thaumarchaeota T Universal stress protein - - - - - - - - - - - - Usp CMS1_k127_3893611_2 1229909.NSED_02910 1.868e-15 78.0 arCOG14076@1|root,arCOG14076@2157|Archaea 1229909.NSED_02910|- - - - - - - - - - - - - - - - CMS1_k127_3893611_1 396588.Tgr7_0813 1.516e-43 164.0 COG0778@1|root,COG0778@2|Bacteria,1NMNU@1224|Proteobacteria 1224|Proteobacteria C Putative TM nitroreductase - - - - - - - - - - - - Nitroreductase CMS1_k127_3893611_0 436308.Nmar_1309 4.739e-276 852.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig CMS1_k127_3900392_7 1229909.NSED_08170 6.205e-63 216.0 arCOG08638@1|root,arCOG08638@2157|Archaea,41T08@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3900392_1 436308.Nmar_1482 0.0 1370.0 COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota 651137|Thaumarchaeota C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C CMS1_k127_3900392_6 1229909.NSED_08160 1.473e-70 245.0 arCOG08637@1|root,arCOG08637@2157|Archaea,41SV0@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_3900392_2 436308.Nmar_1479 1.642e-181 571.0 COG0214@1|root,arCOG04075@2157|Archaea,41SEJ@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the PdxS SNZ family - - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ CMS1_k127_3900392_5 1229909.NSED_08150 1.225e-84 284.0 COG0311@1|root,arCOG00034@2157|Archaea,41SIZ@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS pdxT - 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SNO CMS1_k127_3900392_0 1229909.NSED_08040 0.0 1441.0 COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota 651137|Thaumarchaeota J Anticodon-binding domain of tRNA - - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 CMS1_k127_3900392_3 1229909.NSED_08035 2.409e-151 482.0 COG0720@1|root,arCOG02172@2157|Archaea,41SY8@651137|Thaumarchaeota 651137|Thaumarchaeota H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS CMS1_k127_3900392_8 436308.Nmar_1468 4.217e-44 161.0 COG2154@1|root,arCOG02939@2157|Archaea,41SSQ@651137|Thaumarchaeota 651137|Thaumarchaeota H pterin-4-alpha-carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a CMS1_k127_3900392_4 1229909.NSED_08025 1.441e-108 355.0 COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota 651137|Thaumarchaeota E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase CMS1_k127_3907101_1 436308.Nmar_0242 1.799e-159 504.0 COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota 651137|Thaumarchaeota L Belongs to the MCM family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_N,MCM_OB CMS1_k127_3907101_0 1229909.NSED_01125 0.0 1174.0 COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks hel308 - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,HHH_5,Helicase_C CMS1_k127_3907101_2 436308.Nmar_0244 3.85e-125 406.0 COG0472@1|root,arCOG03199@2157|Archaea,41S8B@651137|Thaumarchaeota 651137|Thaumarchaeota M glycosyl transferase family - - 2.7.8.15 ko:K01001 ko00510,ko01100,map00510,map01100 M00055 R05969 RC00002 ko00000,ko00001,ko00002,ko01000,ko01003 - - - Glycos_transf_4 CMS1_k127_3917694_0 436308.Nmar_0886 0.0 998.0 COG0129@1|root,arCOG04045@2157|Archaea,41SD0@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD CMS1_k127_3917694_1 436308.Nmar_0885 1.088e-27 112.0 arCOG10558@1|root,arCOG10558@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3985581_1 1229909.NSED_06365 2.876e-53 195.0 arCOG08038@1|root,arCOG08643@1|root,arCOG08038@2157|Archaea,arCOG08643@2157|Archaea 2157|Archaea S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_3985581_0 1229909.NSED_04335 7.924e-232 720.0 COG0034@1|root,arCOG00093@2157|Archaea,41S7N@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran CMS1_k127_3993758_2 1229909.NSED_03345 4.119e-59 205.0 COG1260@1|root,arCOG04213@2157|Archaea,41SEZ@651137|Thaumarchaeota 651137|Thaumarchaeota I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth CMS1_k127_3993758_0 1229909.NSED_03350 2.269e-103 341.0 COG0388@1|root,arCOG00062@2157|Archaea 2157|Archaea H Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase CMS1_k127_3993758_3 1229909.NSED_07005 2.729e-42 158.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_3993758_1 1229909.NSED_03355 1.214e-77 261.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge CMS1_k127_400566_1 436308.Nmar_0100 7.041e-86 286.0 COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatD - 6.3.5.7 ko:K09482 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - Asparaginase CMS1_k127_400566_0 436308.Nmar_0099 1.586e-282 880.0 COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatE - 6.3.5.7 ko:K03330 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - GAD,GatB_N,GatB_Yqey CMS1_k127_4022715_3 436308.Nmar_1039 4.611e-71 241.0 COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota 651137|Thaumarchaeota L tRNA intron endonuclease, N-terminal domain - - 4.6.1.16 ko:K01170 - - - - ko00000,ko01000,ko03016 - - - tRNA_int_endo,tRNA_int_endo_N CMS1_k127_4022715_4 436308.Nmar_1041 7.429e-56 197.0 arCOG08726@1|root,arCOG08726@2157|Archaea,41STN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4022715_5 1229909.NSED_06125 2.064e-35 135.0 arCOG08727@1|root,arCOG08727@2157|Archaea,41T57@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4022715_0 1229909.NSED_06130 3.7e-322 992.0 COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota 651137|Thaumarchaeota I Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short CMS1_k127_4022715_2 1229909.NSED_06135 1.388e-72 246.0 arCOG10570@1|root,arCOG10570@2157|Archaea,41T75@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4022715_1 1229909.NSED_06140 2.829e-114 373.0 COG0730@1|root,arCOG02050@2157|Archaea,41SKY@651137|Thaumarchaeota 651137|Thaumarchaeota S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE CMS1_k127_4022715_6 1229909.NSED_06145 2.358e-11 67.0 arCOG10571@1|root,arCOG10571@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4036721_2 1229909.NSED_08480 4.104e-67 232.0 COG1290@1|root,arCOG01721@2157|Archaea,41SDA@651137|Thaumarchaeota 651137|Thaumarchaeota C Cytochrome b subunit of the bc complex - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B CMS1_k127_4036721_1 1229909.NSED_08475 3.467e-70 241.0 COG3794@1|root,arCOG02926@2157|Archaea,41SPG@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Copper binding proteins, plastocyanin azurin family - - - - - - - - - - - - Copper-bind CMS1_k127_4036721_3 1229909.NSED_08470 1.253e-57 203.0 arCOG08633@1|root,arCOG08633@2157|Archaea,41SUK@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4036721_0 1229909.NSED_08465 8.265e-119 387.0 COG0122@1|root,arCOG00464@2157|Archaea,41SHE@651137|Thaumarchaeota 651137|Thaumarchaeota L 8-oxoguanine DNA glycosylase - - 4.2.99.18 ko:K03660 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD CMS1_k127_4044139_0 1229909.NSED_05490 1.442e-286 885.0 COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota 651137|Thaumarchaeota E Peptidase family M1 domain - - 3.4.11.2 ko:K01256,ko:K13722 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 CMS1_k127_4097149_3 523841.HFX_2740 7.276e-53 196.0 COG2086@1|root,arCOG00446@2157|Archaea,2XTB8@28890|Euryarchaeota,23TTZ@183963|Halobacteria 183963|Halobacteria C Electron transfer flavoprotein, beta subunit etfB2 - - ko:K03521 - - - - ko00000 - - - ETF CMS1_k127_4097149_1 1131266.ARWQ01000002_gene513 2.719e-164 525.0 COG2025@1|root,arCOG00448@2157|Archaea,41SZJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Electron transfer flavoprotein domain - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha CMS1_k127_4097149_0 1131266.ARWQ01000002_gene512 2.334e-291 904.0 COG0644@1|root,COG2440@1|root,arCOG00570@2157|Archaea,arCOG01984@2157|Archaea,41SXJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - ko:K00313 - - - - ko00000,ko01000 - - - - CMS1_k127_4097149_2 1459636.NTE_02477 2.02e-62 219.0 COG0317@1|root,arCOG06870@2157|Archaea 2157|Archaea KT HD domain - - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - HD_4 CMS1_k127_4099153_1 1229909.NSED_08325 2.225e-119 385.0 COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - CMS1_k127_4099153_0 1229909.NSED_08330 3.078e-146 465.0 COG0714@1|root,arCOG00441@2157|Archaea,41SDZ@651137|Thaumarchaeota 651137|Thaumarchaeota S ATPase family associated with various cellular activities (AAA) - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5 CMS1_k127_4099153_2 436308.Nmar_1516 3.568e-68 233.0 COG2304@1|root,arCOG02900@2157|Archaea,41SDY@651137|Thaumarchaeota 651137|Thaumarchaeota S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - CMS1_k127_4118619_1 1229909.NSED_06185 6.526e-149 479.0 COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota 651137|Thaumarchaeota L modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD CMS1_k127_4118619_2 1229909.NSED_06180 6.653e-112 372.0 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - - - - - - - - - - - CHASE4,HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg,sCache_3_3 CMS1_k127_4118619_3 1229909.NSED_06170 1.793e-45 166.0 COG0784@1|root,arCOG02391@2157|Archaea,41TB0@651137|Thaumarchaeota 651137|Thaumarchaeota T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg CMS1_k127_4118619_0 1229909.NSED_06165 3.144e-156 499.0 COG1855@1|root,arCOG04116@2157|Archaea,41SX0@651137|Thaumarchaeota 651137|Thaumarchaeota S Large family of predicted nucleotide-binding domains - - - ko:K06865 - - - - ko00000 - - - KH_1,T2SSE CMS1_k127_4122859_0 1229909.NSED_01560 9.345e-208 653.0 COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota 651137|Thaumarchaeota M TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) - - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS CMS1_k127_4122859_1 436308.Nmar_0324 4.518e-84 282.0 COG0522@1|root,arCOG04239@2157|Archaea,41SN3@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rps4 - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S4 CMS1_k127_4122859_2 436308.Nmar_0325 1.636e-80 273.0 COG0099@1|root,arCOG01722@2157|Archaea,41SIW@651137|Thaumarchaeota 651137|Thaumarchaeota J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rps13 - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 CMS1_k127_4126057_2 1229909.NSED_02460 1.305e-37 142.0 COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC CMS1_k127_4126057_0 436308.Nmar_0490 9.807e-233 724.0 COG0001@1|root,arCOG00918@2157|Archaea,41SDE@651137|Thaumarchaeota 651137|Thaumarchaeota H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS1_k127_4126057_1 1229909.NSED_02445 2.941e-101 333.0 COG0580@1|root,arCOG04431@2157|Archaea,41SJI@651137|Thaumarchaeota 651137|Thaumarchaeota G Major Intrinsic Protein - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP CMS1_k127_4126057_3 1229909.NSED_02440 9.879e-22 94.0 COG0394@1|root,arCOG04425@2157|Archaea,41T49@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM low molecular weight phosphotyrosine protein phosphatase - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc CMS1_k127_421955_2 436308.Nmar_0227 6.197e-20 89.0 COG2075@1|root,arCOG01950@2157|Archaea,41T7M@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl24e - - ko:K02896 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L24e CMS1_k127_421955_1 1229909.NSED_00965 2.199e-72 245.0 COG0105@1|root,arCOG04313@2157|Archaea,41SN1@651137|Thaumarchaeota 651137|Thaumarchaeota F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK CMS1_k127_421955_0 436308.Nmar_0229 0.0 1043.0 COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota 651137|Thaumarchaeota J Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 infB - - ko:K03243 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,GTP_EFTU_D4,IF-2 CMS1_k127_4239534_1 1229909.NSED_05565 8.972e-124 400.0 COG0171@1|root,arCOG00069@2157|Archaea,41SJ9@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase CMS1_k127_4239534_0 436308.Nmar_0967 4.002e-237 739.0 COG0215@1|root,arCOG00486@2157|Archaea,41SEW@651137|Thaumarchaeota 651137|Thaumarchaeota J PFAM tRNA synthetases class I (C) catalytic domain cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g CMS1_k127_4239534_2 1229909.NSED_05595 2.258e-43 159.0 arCOG08644@1|root,arCOG08644@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4239534_3 1229909.NSED_05605 1.063e-13 74.0 COG2430@1|root,arCOG01766@2157|Archaea,41T8S@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF432) - - - ko:K09149 - - - - ko00000 - - - DUF432 CMS1_k127_4239669_0 1459636.NTE_01196 8.172e-25 109.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5 CMS1_k127_4239669_2 1349822.NSB1T_03520 5.909e-10 65.0 COG1733@1|root,COG1733@2|Bacteria,4NT53@976|Bacteroidetes,2FSMK@200643|Bacteroidia,22Y9M@171551|Porphyromonadaceae 976|Bacteroidetes K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR CMS1_k127_4239669_1 46429.BV95_02863 1.583e-16 86.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2K0IP@204457|Sphingomonadales 204457|Sphingomonadales Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HCBP_related,He_PIG,HemolysinCabind CMS1_k127_4247079_0 547559.Nmag_2046 3.614e-86 304.0 COG1215@1|root,arCOG01389@2157|Archaea,2XVEG@28890|Euryarchaeota,23UEZ@183963|Halobacteria 183963|Halobacteria M COG1215 Glycosyltransferases, probably involved in cell wall biogenesis - - - - - - - - - - - - Glyco_tranf_2_3 CMS1_k127_4247079_1 1459636.NTE_00257 5.514e-09 59.0 arCOG06883@1|root,arCOG06883@2157|Archaea,41TAV@651137|Thaumarchaeota 2157|Archaea - - - - - - - - - - - - - - DUF2334,DZR CMS1_k127_4328568_0 436308.Nmar_0496 3.906e-165 524.0 COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufD - - - ko:K09014,ko:K09015 - - - - ko00000 - - - UPF0051 CMS1_k127_4328568_1 1229909.NSED_02480 2.905e-93 306.0 COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufB - - - ko:K09014 - - - - ko00000 - - - UPF0051 CMS1_k127_433426_0 436308.Nmar_1066 3.729e-258 797.0 COG0017@1|root,arCOG00406@2157|Archaea,41S93@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - - - - - - - - - - tRNA-synt_2,tRNA_anti-codon CMS1_k127_433426_3 1229909.NSED_06230 2.978e-37 141.0 arCOG08788@1|root,arCOG08788@2157|Archaea,41T6K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_433426_2 436308.Nmar_1068 4.264e-40 151.0 arCOG11451@1|root,arCOG11451@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_433426_4 436308.Nmar_0030 1.4e-14 82.0 arCOG06534@1|root,arCOG06534@2157|Archaea 2157|Archaea S acid phosphatase activity - - - - - - - - - - - - He_PIG CMS1_k127_4345619_4 1229909.NSED_02560 2.354e-11 65.0 COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) - - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH CMS1_k127_4345619_3 1229909.NSED_01230 7.467e-22 95.0 COG5466@1|root,arCOG05278@2157|Archaea,41T8X@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF1059) - - - - - - - - - - - - DUF1059 CMS1_k127_4345619_2 1229909.NSED_01235 1.103e-144 462.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 CMS1_k127_4345619_0 1229909.NSED_01260 4.276e-318 976.0 COG4799@1|root,arCOG02705@2157|Archaea,41SEH@651137|Thaumarchaeota 651137|Thaumarchaeota I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 2.1.3.15,6.4.1.2,6.4.1.3 ko:K18604 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko01000 - - - Carboxyl_trans CMS1_k127_4345619_1 1229909.NSED_01265 1.124e-240 746.0 COG0439@1|root,arCOG01590@2157|Archaea,41SXC@651137|Thaumarchaeota 651137|Thaumarchaeota I Carbamoyl-phosphate synthase L chain - - 6.4.1.2,6.4.1.3 ko:K18603 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS1_k127_4419747_3 1459636.NTE_03342 9.889e-18 96.0 arCOG10350@1|root,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - CMS1_k127_4419747_4 1185876.BN8_06035 5.329e-14 84.0 2E7UU@1|root,32VRP@2|Bacteria,4NUH3@976|Bacteroidetes,47RD2@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS1_k127_4419747_0 1229909.NSED_02340 6.867e-54 194.0 COG0454@1|root,arCOG00826@2157|Archaea 2157|Archaea K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 CMS1_k127_4419747_2 1131266.ARWQ01000001_gene1346 8.596e-26 121.0 arCOG08812@1|root,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4419747_1 436308.Nmar_1649 1.742e-31 138.0 arCOG10597@1|root,arCOG10597@2157|Archaea 2157|Archaea O serine-type endopeptidase activity - - - - - - - - - - - - - CMS1_k127_4430885_3 436308.Nmar_0645 4.72e-13 69.0 arCOG10532@1|root,arCOG10532@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4430885_2 1229909.NSED_03335 4.206e-95 317.0 COG1938@1|root,arCOG00347@2157|Archaea,41T2Y@651137|Thaumarchaeota 651137|Thaumarchaeota S PAC2 family - - - ko:K06869 - - - - ko00000 - - - PAC2 CMS1_k127_4430885_1 1229909.NSED_03340 3.743e-177 558.0 COG1899@1|root,arCOG04142@2157|Archaea,41SDB@651137|Thaumarchaeota 651137|Thaumarchaeota O Deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS CMS1_k127_4430885_0 436308.Nmar_0649 4.919e-218 679.0 COG1260@1|root,arCOG04213@2157|Archaea,41SEZ@651137|Thaumarchaeota 651137|Thaumarchaeota I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth CMS1_k127_4454692_1 436308.Nmar_0200 2.063e-54 194.0 arCOG08634@1|root,arCOG08634@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4454692_0 436308.Nmar_0201 1.189e-160 509.0 COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM CMS1_k127_4454692_2 1229909.NSED_00810 4.636e-47 170.0 COG0640@1|root,arCOG00731@2157|Archaea,41T40@651137|Thaumarchaeota 651137|Thaumarchaeota K Bacterial regulatory protein, arsR family - - - - - - - - - - - - HTH_5 CMS1_k127_4454692_4 1229909.NSED_00815 3.071e-39 147.0 arCOG10520@1|root,arCOG10520@2157|Archaea,41T7W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4454692_3 436308.Nmar_0204 1.296e-41 155.0 arCOG10529@1|root,arCOG10529@2157|Archaea,41SSF@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4471683_8 436308.Nmar_1724 4.055e-74 250.0 COG0006@1|root,arCOG01000@2157|Archaea,41T14@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the peptidase M24B family - - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 CMS1_k127_4471683_3 436308.Nmar_1725 4.299e-183 576.0 COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI CMS1_k127_4471683_0 436308.Nmar_1727 0.0 1226.0 COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota 651137|Thaumarchaeota S RNA-metabolising metallo-beta-lactamase - - - ko:K07041 - - - - ko00000 - - - Beta-Casp,KH_7,Lactamase_B_6,RMMBL CMS1_k127_4471683_7 436308.Nmar_1728 9.485e-126 404.0 COG0638@1|root,arCOG00970@2157|Archaea,41T1N@651137|Thaumarchaeota 651137|Thaumarchaeota O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation - - 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome CMS1_k127_4471683_2 436308.Nmar_1729 1.798e-185 584.0 COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 CMS1_k127_4471683_5 436308.Nmar_1730 7.414e-130 417.0 COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota 651137|Thaumarchaeota O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C CMS1_k127_4471683_1 1229909.NSED_09215 1.673e-230 715.0 COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS1_k127_4471683_9 436308.Nmar_1732 2.886e-70 241.0 COG1056@1|root,arCOG00972@2157|Archaea,41T7B@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.1 ko:K00952 ko00760,ko01100,map00760,map01100 - R00137,R03005 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like CMS1_k127_4471683_6 436308.Nmar_1733 1.711e-128 419.0 COG0430@1|root,arCOG04125@2157|Archaea,41T1K@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC CMS1_k127_4471683_11 309801.trd_0479 8.576e-05 51.0 COG5615@1|root,COG5615@2|Bacteria,2GBBE@200795|Chloroflexi,27YNG@189775|Thermomicrobia 189775|Thermomicrobia S Domain of unknown function (DUF4149) - - - - - - - - - - - - CopD CMS1_k127_4471683_10 436308.Nmar_1735 1.505e-55 198.0 arCOG03788@1|root,arCOG03788@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - LEA_2 CMS1_k127_4471683_4 1229909.NSED_09240 6.236e-133 426.0 COG0778@1|root,arCOG00288@2157|Archaea,41S7D@651137|Thaumarchaeota 651137|Thaumarchaeota C Cob(II)yrinic acid a,c-diamide reductase - - 1.13.11.79 ko:K04719 ko00740,ko01100,map00740,map01100 - R09083 RC00435,RC02413 ko00000,ko00001,ko01000 - - - Nitroreductase CMS1_k127_4510319_0 436308.Nmar_0242 0.0 1050.0 COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota 651137|Thaumarchaeota L Belongs to the MCM family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_N,MCM_OB CMS1_k127_4533809_0 436308.Nmar_1628 0.0 1061.0 COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota 651137|Thaumarchaeota FK Anaerobic ribonucleoside-triphosphate reductase - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,HTH_20,NRDD CMS1_k127_4533809_1 436308.Nmar_1627 2.354e-13 69.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN CMS1_k127_4534999_2 1229909.NSED_05330 4.427e-22 103.0 COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional - - - - - - - - - - - - TrmB CMS1_k127_4534999_1 1229909.NSED_04815 5.385e-29 120.0 COG0745@1|root,arCOG02595@2157|Archaea,41T9R@651137|Thaumarchaeota 651137|Thaumarchaeota T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS1_k127_4534999_0 1229909.NSED_04820 9.905e-103 345.0 COG0642@1|root,arCOG02362@1|root,arCOG02358@2157|Archaea,arCOG02362@2157|Archaea 2157|Archaea T Histidine kinase - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CHASE4,HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1,sCache_3_3 CMS1_k127_4538083_5 1229909.NSED_00660 2.913e-11 63.0 COG0516@1|root,arCOG00612@2157|Archaea,41S7R@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH CMS1_k127_4538083_3 436308.Nmar_1568 8.412e-49 179.0 arCOG08827@1|root,arCOG08827@2157|Archaea,41SUW@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4538083_1 436308.Nmar_1567 9.934e-138 441.0 COG0077@1|root,arCOG00255@2157|Archaea,41SA8@651137|Thaumarchaeota 651137|Thaumarchaeota E Prephenate dehydratase - - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDT CMS1_k127_4538083_2 436308.Nmar_1566 1.005e-92 306.0 COG1096@1|root,arCOG00676@2157|Archaea,41SQA@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs csl4 - - ko:K07573 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - - CMS1_k127_4538083_0 1229909.NSED_00680 1.882e-212 662.0 COG0604@1|root,arCOG01458@2157|Archaea,41SX7@651137|Thaumarchaeota 651137|Thaumarchaeota C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N CMS1_k127_4538083_4 436308.Nmar_1564 4.001e-43 159.0 arCOG05195@1|root,arCOG05195@2157|Archaea 2157|Archaea S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_6,TPR_8 CMS1_k127_4573364_3 1229909.NSED_01605 1.481e-40 156.0 arCOG08038@1|root,arCOG10597@1|root,arCOG08038@2157|Archaea,arCOG10597@2157|Archaea,41SZN@651137|Thaumarchaeota 651137|Thaumarchaeota O serine-type endopeptidase activity - - - - - - - - - - - - - CMS1_k127_4573364_0 1229909.NSED_03925 5.96e-223 699.0 COG5427@1|root,arCOG00563@2157|Archaea 2157|Archaea S membrane - - - - - - - - - - - - PMT_2 CMS1_k127_4573364_1 1229909.NSED_03920 3.826e-208 653.0 COG0463@1|root,arCOG00894@2157|Archaea,41SAS@651137|Thaumarchaeota 651137|Thaumarchaeota M glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2,GtrA CMS1_k127_4573364_2 1459636.NTE_00321 2.439e-41 154.0 arCOG11305@1|root,arCOG11305@2157|Archaea,41T7G@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4614501_0 436308.Nmar_1621 4.506e-100 329.0 COG2301@1|root,arCOG00760@2157|Archaea,41S6F@651137|Thaumarchaeota 651137|Thaumarchaeota G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI CMS1_k127_4614501_1 436308.Nmar_1618 6.222e-76 261.0 arCOG05137@1|root,arCOG05137@2157|Archaea 2157|Archaea S TPR repeat - - - ko:K07126 - - - - ko00000 - - - TPR_1,TPR_8 CMS1_k127_4614501_2 436308.Nmar_1591 1.234e-57 207.0 arCOG07442@1|root,arCOG07442@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4618945_0 436308.Nmar_0348 0.0 1039.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 CMS1_k127_4619542_3 436308.Nmar_0783 2.816e-27 111.0 arCOG10549@1|root,arCOG10549@2157|Archaea,41STE@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4619542_0 436308.Nmar_0784 1.444e-145 464.0 COG0152@1|root,arCOG04421@2157|Archaea,41SAR@651137|Thaumarchaeota 651137|Thaumarchaeota F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt CMS1_k127_4619542_1 436308.Nmar_0785 2.997e-76 259.0 COG0640@1|root,arCOG01687@2157|Archaea,41ST3@651137|Thaumarchaeota 651137|Thaumarchaeota K Helix-turn-helix domain - - - - - - - - - - - - HTH_20 CMS1_k127_4619542_2 436308.Nmar_0787 7.145e-58 203.0 arCOG00516@1|root,arCOG00516@2157|Archaea,41SS2@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate - - - - - - - - - - - - Putative_PNPOx CMS1_k127_4628108_1 436308.Nmar_0987 1.277e-115 374.0 COG1405@1|root,arCOG01981@2157|Archaea,41SYU@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon CMS1_k127_4628108_0 1229909.NSED_05690 5.792e-146 471.0 COG0457@1|root,COG5549@1|root,arCOG03038@2157|Archaea,arCOG04994@2157|Archaea,41T10@651137|Thaumarchaeota 651137|Thaumarchaeota O Zinc-dependent metalloprotease - - - - - - - - - - - - Peptidase_M10,TPR_8 CMS1_k127_4642946_1 1229909.NSED_02060 4.341e-53 194.0 arCOG08716@1|root,arCOG08716@2157|Archaea 1229909.NSED_02060|- - - - - - - - - - - - - - - - CMS1_k127_4642946_0 1229909.NSED_06570 8.987e-158 501.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon CMS1_k127_4642946_5 1229909.NSED_05075 2.865e-12 67.0 arCOG11444@1|root,arCOG11444@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4642946_3 1229909.NSED_03535 1.088e-28 119.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II CMS1_k127_4642946_2 1120934.KB894404_gene746 1.334e-35 154.0 COG1520@1|root,COG1680@1|root,COG1520@2|Bacteria,COG1680@2|Bacteria,2HSCZ@201174|Actinobacteria,4EDAG@85010|Pseudonocardiales 201174|Actinobacteria V Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - CMS1_k127_4642946_4 436308.Nmar_0333 5.637e-18 96.0 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4642946_6 553178.CAPGI0001_2409 3.8e-11 74.0 COG2374@1|root,COG3391@1|root,COG4935@1|root,COG5276@1|root,COG2374@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,COG5276@2|Bacteria,4NEN7@976|Bacteroidetes,1HWMS@117743|Flavobacteriia,1ER48@1016|Capnocytophaga 976|Bacteroidetes O Thrombospondin type 3 - - - - - - - - - - - - CHU_C,P_proprotein,Reprolysin_4,TSP_3 CMS1_k127_4681278_0 436308.Nmar_1177 1.236e-303 940.0 COG1164@1|root,arCOG04758@2157|Archaea,41S7J@651137|Thaumarchaeota 651137|Thaumarchaeota E Peptidase family M3 - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N CMS1_k127_4681278_1 436308.Nmar_1178 7.049e-36 138.0 arCOG11736@1|root,arCOG11736@2157|Archaea,41T70@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_46815_5 1131266.ARWQ01000014_gene87 2.085e-05 49.0 COG4122@1|root,arCOG00979@2157|Archaea,41SMF@651137|Thaumarchaeota 651137|Thaumarchaeota S O-methyltransferase - - - - - - - - - - - - Methyltransf_3 CMS1_k127_46815_3 203124.Tery_3996 5.068e-11 69.0 COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales 1117|Cyanobacteria L Tetratricopeptide repeat - - - ko:K12600 ko03018,map03018 M00392 - - ko00000,ko00001,ko00002,ko03019 - - - TPR_1,TPR_2,TPR_8 CMS1_k127_46815_6 1173024.KI912148_gene3593 2.765e-05 55.0 COG4454@1|root,COG4454@2|Bacteria,1G83X@1117|Cyanobacteria,1JM2H@1189|Stigonemataceae 1117|Cyanobacteria P Sulfocyanin (SoxE) domain - - - - - - - - - - - - Cupredoxin_1,SoxE CMS1_k127_46815_2 436308.Nmar_1358 2.464e-50 191.0 COG0491@1|root,arCOG00507@2157|Archaea 2157|Archaea S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B CMS1_k127_46815_1 1229909.NSED_02095 1.848e-56 199.0 COG3439@1|root,arCOG02761@2157|Archaea 2157|Archaea S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 CMS1_k127_46815_0 102129.Lepto7375DRAFT_2070 2.698e-76 265.0 COG0384@1|root,COG0384@2|Bacteria,1G0Y0@1117|Cyanobacteria,1H7VM@1150|Oscillatoriales 1117|Cyanobacteria S TIGRFAM phenazine biosynthesis protein PhzF family - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF CMS1_k127_46815_7 675816.VIA_003167 0.000119 55.0 2AX3X@1|root,31P2A@2|Bacteria,1QKRC@1224|Proteobacteria,1TIVX@1236|Gammaproteobacteria,1XZT4@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - CMS1_k127_46815_8 1229909.NSED_00535 0.0003034 52.0 arCOG08777@1|root,arCOG08777@2157|Archaea 1229909.NSED_00535|- - - - - - - - - - - - - - - - CMS1_k127_468186_0 436308.Nmar_0066 1.003e-164 522.0 COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota 651137|Thaumarchaeota L Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priS - - ko:K02683 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_S CMS1_k127_468186_1 1229909.NSED_00030 2.775e-79 267.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 CMS1_k127_4732477_5 1229909.NSED_00025 9.529e-40 148.0 COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota 651137|Thaumarchaeota L Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priS - - ko:K02683 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_S CMS1_k127_4732477_1 1229909.NSED_00020 1.06e-176 557.0 COG2219@1|root,arCOG03013@2157|Archaea,41SCD@651137|Thaumarchaeota 651137|Thaumarchaeota L Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priL - - ko:K18882 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_lrg CMS1_k127_4732477_2 436308.Nmar_0064 6.765e-152 483.0 COG0648@1|root,arCOG01894@2157|Archaea,41SDW@651137|Thaumarchaeota 651137|Thaumarchaeota L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 CMS1_k127_4732477_0 436308.Nmar_0063 7.107e-286 881.0 COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota 651137|Thaumarchaeota J synthetase (class II) - - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b CMS1_k127_4732477_3 1229909.NSED_09935 5.595e-119 384.0 COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - CMS1_k127_4732477_4 1229909.NSED_09930 3.444e-61 216.0 COG1794@1|root,arCOG02005@2157|Archaea,41SM4@651137|Thaumarchaeota 651137|Thaumarchaeota M Asp/Glu/Hydantoin racemase - - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race CMS1_k127_47332_4 436308.Nmar_1578 2.66e-35 136.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 CMS1_k127_47332_2 1229909.NSED_00610 1.587e-50 180.0 COG1631@1|root,arCOG04109@2157|Archaea,41SQZ@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl44e - - ko:K02929 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L44 CMS1_k127_47332_6 933801.Ahos_1251 1.555e-11 66.0 COG2051@1|root,arCOG04108@2157|Archaea,2XR0Y@28889|Crenarchaeota 28889|Crenarchaeota J PFAM ribosomal protein rps27e GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02978 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S27e CMS1_k127_47332_1 1229909.NSED_00600 2.965e-71 246.0 COG2266@1|root,arCOG01871@2157|Archaea,41SRI@651137|Thaumarchaeota 651137|Thaumarchaeota M MobA-like NTP transferase domain - - 2.7.7.62 ko:K19712 ko00860,ko01100,map00860,map01100 - R05222 RC00002 ko00000,ko00001,ko01000 - - - NTP_transf_3 CMS1_k127_47332_5 391623.TERMP_00553 5.916e-24 110.0 COG0368@1|root,arCOG04338@2157|Archaea,2XU3T@28890|Euryarchaeota,242V6@183968|Thermococci 183968|Thermococci H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS CMS1_k127_47332_0 436308.Nmar_1583 1.937e-141 455.0 COG1270@1|root,arCOG04274@2157|Archaea,41S6I@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib CMS1_k127_47332_3 436308.Nmar_1584 1.302e-46 169.0 COG1492@1|root,arCOG00105@2157|Archaea,41SG6@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - CbiA CMS1_k127_4754638_3 436308.Nmar_1523 6.419e-49 177.0 COG0347@1|root,arCOG02305@2157|Archaea,41TB5@651137|Thaumarchaeota 651137|Thaumarchaeota K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II CMS1_k127_4754638_2 436308.Nmar_1522 1.095e-49 185.0 arCOG08643@1|root,arCOG08643@2157|Archaea,41T5M@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_4754638_1 436308.Nmar_1521 1.908e-84 283.0 arCOG10589@1|root,arCOG10589@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4754638_5 436308.Nmar_1520 1.519e-28 116.0 arCOG10588@1|root,arCOG10588@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4754638_0 436308.Nmar_1519 4.819e-105 343.0 COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota 651137|Thaumarchaeota K General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation - - - ko:K03120 ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203 - - - ko00000,ko00001,ko03000,ko03021 - - - TBP CMS1_k127_4754638_4 1229909.NSED_08345 9.669e-30 119.0 arCOG04405@1|root,arCOG04405@2157|Archaea 2157|Archaea S ASCH domain - - - - - - - - - - - - ASCH CMS1_k127_4782114_0 1229909.NSED_02080 2.602e-56 200.0 COG0071@1|root,arCOG01833@2157|Archaea,41SPJ@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS1_k127_4782114_3 1229909.NSED_02085 0.0005555 44.0 arCOG12097@1|root,arCOG12097@2157|Archaea 1229909.NSED_02085|- - - - - - - - - - - - - - - - CMS1_k127_4782114_1 436308.Nmar_0305 4.975e-42 155.0 arCOG08781@1|root,arCOG08781@2157|Archaea,41SVY@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4795857_2 1229909.NSED_02390 3.673e-68 233.0 arCOG08735@1|root,arCOG08735@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4795857_0 1229909.NSED_02370 1.738e-109 358.0 arCOG08734@1|root,arCOG08734@2157|Archaea,41SP9@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4795857_1 436308.Nmar_0469 1.747e-78 265.0 arCOG10527@1|root,arCOG10527@2157|Archaea,41SPB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4795857_3 1229909.NSED_02360 8.374e-38 145.0 COG0457@1|root,arCOG03032@2157|Archaea,41T5X@651137|Thaumarchaeota 651137|Thaumarchaeota S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 CMS1_k127_4796017_4 436308.Nmar_0512 5.489e-26 107.0 COG1522@1|root,arCOG01628@2157|Archaea,41SA2@651137|Thaumarchaeota 651137|Thaumarchaeota K COG1522 Transcriptional regulators - - - - - - - - - - - - - CMS1_k127_4796017_3 1229909.NSED_02575 1.295e-44 164.0 arCOG10528@1|root,arCOG10528@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4796017_0 436308.Nmar_0514 2.536e-179 565.0 COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota 651137|Thaumarchaeota C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS1_k127_4796017_1 1131266.ARWQ01000005_gene828 2.368e-109 357.0 COG3253@1|root,arCOG03031@2157|Archaea,41SGX@651137|Thaumarchaeota 651137|Thaumarchaeota S Chlorite dismutase - - - - - - - - - - - - Chlor_dismutase CMS1_k127_4796017_5 1229909.NSED_02590 3.53e-19 88.0 COG1872@1|root,arCOG04058@2157|Archaea,41TAX@651137|Thaumarchaeota 651137|Thaumarchaeota S DUF167 - - - ko:K09131 - - - - ko00000 - - - DUF167 CMS1_k127_4796017_2 1229909.NSED_02595 6.086e-76 256.0 COG0396@1|root,arCOG04236@2157|Archaea,41SE1@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly ATPase SufC - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran CMS1_k127_485642_2 1229909.NSED_06265 1.218e-56 198.0 COG0440@1|root,arCOG04445@2157|Archaea,41SNS@651137|Thaumarchaeota 651137|Thaumarchaeota E acetolactate synthase, small - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C CMS1_k127_485642_0 1229909.NSED_06270 0.0 1039.0 COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N CMS1_k127_485642_1 436308.Nmar_1077 1.285e-61 215.0 arCOG10267@1|root,arCOG10267@2157|Archaea,41STA@651137|Thaumarchaeota 651137|Thaumarchaeota S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 CMS1_k127_4868050_8 436308.Nmar_1318 1.551e-33 131.0 COG1826@1|root,arCOG02694@2157|Archaea,41SRR@651137|Thaumarchaeota 651137|Thaumarchaeota U mttA/Hcf106 family - - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 CMS1_k127_4868050_1 436308.Nmar_1316 4.483e-206 646.0 COG0477@1|root,arCOG00130@2157|Archaea,41T0X@651137|Thaumarchaeota 651137|Thaumarchaeota G major facilitator superfamily - - - ko:K08153,ko:K08221 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8,2.A.1.32 - - MFS_1 CMS1_k127_4868050_3 436308.Nmar_1315 4.409e-129 414.0 COG2226@1|root,arCOG04348@2157|Archaea,41SGQ@651137|Thaumarchaeota 651137|Thaumarchaeota Q ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran CMS1_k127_4868050_2 1229909.NSED_07280 2.288e-130 419.0 COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota 651137|Thaumarchaeota O Proteasome endopeptidase complex - - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome,Proteasome_A_N CMS1_k127_4868050_5 436308.Nmar_1313 1.477e-57 202.0 COG0640@1|root,arCOG00731@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_5 CMS1_k127_4868050_0 436308.Nmar_1312 5.392e-256 793.0 COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS1_k127_4868050_7 1229909.NSED_07265 2.987e-46 169.0 COG1658@1|root,arCOG01486@2157|Archaea,41SU4@651137|Thaumarchaeota 651137|Thaumarchaeota L Toprim domain - - - - - - - - - - - - - CMS1_k127_4868050_4 436308.Nmar_1310 2.193e-111 363.0 COG0518@1|root,arCOG00090@2157|Archaea,41T3Z@651137|Thaumarchaeota 651137|Thaumarchaeota F glutamine amidotransferase - - - - - - - - - - - - GATase CMS1_k127_4868050_6 436308.Nmar_1774 1.036e-55 199.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N CMS1_k127_4898575_5 1229909.NSED_08280 8.155e-79 266.0 arCOG08673@1|root,arCOG08673@2157|Archaea,41SVK@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4898575_6 436308.Nmar_1506 9.582e-56 194.0 arCOG08672@1|root,arCOG08672@2157|Archaea,41SU2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4898575_7 436308.Nmar_1507 4.876e-47 171.0 arCOG10587@1|root,arCOG10587@2157|Archaea,41SVM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_4898575_4 436308.Nmar_1508 2.7e-79 266.0 COG0184@1|root,arCOG04185@2157|Archaea,41SKP@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein rps15 - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13_N,Ribosomal_S15 CMS1_k127_4898575_0 436308.Nmar_1509 8.262e-267 826.0 COG0608@1|root,arCOG00427@2157|Archaea,41SZF@651137|Thaumarchaeota 651137|Thaumarchaeota L DHHA1 domain - - - ko:K07463 - - - - ko00000 - - - DHHA1 CMS1_k127_4898575_1 1229909.NSED_08310 4.742e-222 693.0 COG0172@1|root,arCOG00403@2157|Archaea,41SC9@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b CMS1_k127_4898575_2 436308.Nmar_1512 5.566e-116 374.0 COG1890@1|root,arCOG04186@2157|Archaea,41SM9@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS1 family rps3ae - - ko:K02984 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S3Ae CMS1_k127_4898575_8 1229909.NSED_08320 3.707e-27 113.0 COG1325@1|root,arCOG01042@2157|Archaea,41SWK@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA binding - - - ko:K07581 - - - - ko00000 - - - RNA_binding CMS1_k127_4898575_9 1229909.NSED_08320 4.241e-13 69.0 COG1325@1|root,arCOG01042@2157|Archaea,41SWK@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA binding - - - ko:K07581 - - - - ko00000 - - - RNA_binding CMS1_k127_4898575_3 1229909.NSED_08325 4.172e-114 370.0 COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - CMS1_k127_4983561_4 436308.Nmar_1018 3.51e-27 114.0 arCOG10569@1|root,arCOG10569@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_4983561_2 1229909.NSED_06625 4.762e-35 138.0 COG0589@1|root,arCOG02053@2157|Archaea,41T8M@651137|Thaumarchaeota 651137|Thaumarchaeota T Universal stress protein - - - - - - - - - - - - Usp CMS1_k127_4983561_3 1229909.NSED_06630 3.399e-31 127.0 COG0589@1|root,arCOG02053@2157|Archaea,41T8M@651137|Thaumarchaeota 651137|Thaumarchaeota T Universal stress protein - - - - - - - - - - - - Usp CMS1_k127_4983561_5 1131266.ARWQ01000005_gene843 9.683e-23 98.0 COG1998@1|root,arCOG04183@2157|Archaea,41SWB@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS31 family rps27ae - - ko:K02977 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011,ko04147 - - - Ribosomal_S27 CMS1_k127_4983561_1 436308.Nmar_0535 1.17e-46 171.0 COG2004@1|root,arCOG04182@2157|Archaea,41SWI@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS24 family - - - ko:K02974 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - - CMS1_k127_4983561_0 436308.Nmar_0536 5.064e-81 273.0 COG1547@1|root,arCOG03705@2157|Archaea,41SQ0@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF309) - - - ko:K09763 - - - - ko00000 - - - DUF309 CMS1_k127_5024807_2 1229909.NSED_09510 2.01e-27 113.0 COG1041@1|root,arCOG00047@2157|Archaea 2157|Archaea L RNA methylase trmG10 GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.213 ko:K07446 - - - - ko00000,ko01000,ko03016 - - - THUMP,UPF0020 CMS1_k127_5024807_0 1229909.NSED_09505 9.457e-132 426.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N CMS1_k127_5024807_1 1229909.NSED_09500 5.836e-81 271.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel CMS1_k127_50740_2 1229909.NSED_00910 2.255e-18 92.0 COG3794@1|root,arCOG02926@2157|Archaea 1229909.NSED_00910|- C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - CMS1_k127_50740_1 1229909.NSED_01360 2.234e-18 85.0 COG3369@1|root,arCOG01667@2157|Archaea 2157|Archaea S Zinc finger CDGSH-type domain protein - - - - - - - - - - - - zf-CDGSH CMS1_k127_50740_3 436308.Nmar_1021 0.0002934 48.0 arCOG08738@1|root,arCOG08738@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - SHOCT CMS1_k127_5081597_1 633148.Tagg_0001 2.912e-87 302.0 COG1474@1|root,arCOG00467@2157|Archaea,2XPXH@28889|Crenarchaeota 28889|Crenarchaeota L Involved in regulation of DNA replication cdc6-1 - - ko:K10725 - - - - ko00000,ko03032 - - - AAA_16,AAA_22,Cdc6_C CMS1_k127_5081597_0 436308.Nmar_0002 8.817e-274 846.0 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B CMS1_k127_5081597_2 436308.Nmar_0003 6.403e-69 239.0 arCOG01995@1|root,arCOG01995@2157|Archaea,41T3M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - SpoIIM CMS1_k127_5081597_3 436308.Nmar_0004 8.216e-68 236.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Cupredoxin_1 CMS1_k127_5102434_1 436308.Nmar_1194 1.19e-39 149.0 arCOG08693@1|root,arCOG08693@2157|Archaea,41T7N@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5102434_2 436308.Nmar_1195 5.261e-29 118.0 arCOG10579@1|root,arCOG10579@2157|Archaea,41TAI@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5102434_0 436308.Nmar_1196 1.749e-104 343.0 arCOG08694@1|root,arCOG08694@2157|Archaea,41SZ1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5143465_0 1229909.NSED_02355 3.842e-147 471.0 arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5143465_3 1131266.ARWQ01000010_gene36 4.504e-22 96.0 arCOG11928@1|root,arCOG11928@2157|Archaea,41T8Q@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5143465_4 1229909.NSED_02350 1.225e-21 94.0 arCOG08742@1|root,arCOG08742@2157|Archaea,41TAD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5143465_1 436308.Nmar_0466 1.424e-116 382.0 arCOG08732@1|root,arCOG08732@2157|Archaea,41SR6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5143465_2 1459636.NTE_03244 6.974e-35 136.0 COG1237@1|root,arCOG00503@2157|Archaea 2157|Archaea S PFAM beta-lactamase domain protein - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B,Lactamase_B_2 CMS1_k127_5152847_0 1229909.NSED_03465 2.142e-71 250.0 COG0517@1|root,arCOG00600@2157|Archaea 2157|Archaea K CBS domain - - - ko:K07182 - - - - ko00000 - - - CBS CMS1_k127_5152847_4 1229909.NSED_04715 7.527e-13 71.0 28HMW@1|root,2N5MZ@2157|Archaea,41T97@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5152847_2 436308.Nmar_0855 1.348e-31 125.0 arCOG08032@1|root,arCOG08032@2157|Archaea,41T69@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5152847_1 436308.Nmar_1272 3.493e-52 187.0 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp CMS1_k127_5152847_3 1229909.NSED_08800 8.195e-20 91.0 arCOG06947@1|root,arCOG06947@2157|Archaea,41TAK@651137|Thaumarchaeota 651137|Thaumarchaeota S zinc finger - - - - - - - - - - - - - CMS1_k127_5226202_0 1229909.NSED_05545 1.393e-312 960.0 COG0143@1|root,arCOG00810@2157|Archaea,41SAF@651137|Thaumarchaeota 651137|Thaumarchaeota J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g CMS1_k127_5226202_1 1229909.NSED_05550 1.086e-49 177.0 COG0499@1|root,arCOG04137@2157|Archaea,41S9I@651137|Thaumarchaeota 651137|Thaumarchaeota H S-adenosyl-L-homocysteine hydrolase, NAD binding domain - - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD CMS1_k127_5231978_0 1229909.NSED_04595 2.926e-264 816.0 COG0498@1|root,arCOG01434@2157|Archaea,41S5N@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS1_k127_5231978_1 436308.Nmar_0832 2.022e-212 665.0 COG1253@1|root,arCOG00626@2157|Archaea,41T1G@651137|Thaumarchaeota 651137|Thaumarchaeota S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 CMS1_k127_5231978_2 436308.Nmar_0831 1.577e-163 516.0 COG0057@1|root,arCOG00493@2157|Archaea,41SDF@651137|Thaumarchaeota 651137|Thaumarchaeota G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.59 ko:K00150 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166 R01061,R01063 RC00149 ko00000,ko00001,ko00002,ko01000 - - - - CMS1_k127_5234397_3 436308.Nmar_0396 6.008e-32 128.0 COG0552@1|root,arCOG01227@2157|Archaea,41SCC@651137|Thaumarchaeota 651137|Thaumarchaeota U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N CMS1_k127_5234397_0 436308.Nmar_0397 6.638e-154 490.0 COG0448@1|root,arCOG00912@2157|Archaea,41SEY@651137|Thaumarchaeota 651137|Thaumarchaeota E aspartate ornithine carbamoyltransferase carbamoyl-P binding domain - - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS1_k127_5234397_1 436308.Nmar_0398 2.996e-84 280.0 COG0256@1|root,arCOG04088@2157|Archaea,41SQW@651137|Thaumarchaeota 651137|Thaumarchaeota J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rpl18 - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5e CMS1_k127_5234397_2 1229909.NSED_01930 1.894e-34 132.0 COG0098@1|root,arCOG04087@2157|Archaea,41SFS@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the universal ribosomal protein uS5 family - - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C CMS1_k127_5301494_0 1198449.ACAM_1384 1.021e-21 104.0 COG2064@1|root,arCOG01811@2157|Archaea,arCOG01812@2157|Archaea,2XSNN@28889|Crenarchaeota 28889|Crenarchaeota N Type II secretion system (T2SS), protein F - - - ko:K07333 - - - - ko00000,ko02035,ko02044 - - - T2SSF CMS1_k127_5301494_1 436308.Nmar_0707 9.855e-10 60.0 COG2201@1|root,arCOG02382@2157|Archaea 2157|Archaea NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg CMS1_k127_5308445_4 436308.Nmar_0200 2.197e-15 76.0 arCOG08634@1|root,arCOG08634@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_5308445_1 436308.Nmar_0199 1.349e-34 133.0 arCOG10519@1|root,arCOG10519@2157|Archaea,41T6D@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5308445_2 436308.Nmar_1145 1.563e-26 109.0 COG0526@1|root,arCOG01218@2157|Archaea 2157|Archaea CO TIGRFAM Glutaredoxin-like domain protein - - - - - - - - - - - - Thioredoxin_3 CMS1_k127_5308445_3 1229909.NSED_00785 4.524e-16 78.0 arCOG04508@1|root,arCOG04508@2157|Archaea 1229909.NSED_00785|- P YHS domain - - - - - - - - - - - - - CMS1_k127_5308445_0 436308.Nmar_1144 2.759e-127 414.0 COG0785@1|root,arCOG02398@2157|Archaea 2157|Archaea O cytochrome c biogenesis protein - - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD CMS1_k127_5332122_0 436308.Nmar_1004 8.01e-133 427.0 COG0405@1|root,arCOG04053@2157|Archaea 2157|Archaea E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS1_k127_5332122_1 436308.Nmar_1008 6.752e-83 289.0 COG0458@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01596@2157|Archaea 2157|Archaea EF ATP-grasp domain cxp2 - 3.4.17.11,3.5.1.18,6.3.2.4 ko:K01295,ko:K01439,ko:K01921,ko:K16181 ko00300,ko00473,ko00550,ko01100,ko01120,ko01230,ko01502,map00300,map00473,map00550,map01100,map01120,map01230,map01502 M00016 R01150,R02734,R10011 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011 - - - ATP-grasp_3,CPSase_L_D2,Dala_Dala_lig_C,M20_dimer,Peptidase_M20 CMS1_k127_5357529_1 436308.Nmar_0658 6.919e-205 641.0 COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b CMS1_k127_5357529_2 436308.Nmar_1385 7.716e-171 542.0 COG0731@1|root,arCOG00953@2157|Archaea 2157|Archaea C Radical SAM domain protein rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM CMS1_k127_5357529_0 436308.Nmar_0657 4.836e-244 758.0 COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota 651137|Thaumarchaeota S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase CMS1_k127_5357529_3 1229909.NSED_03365 3.059e-130 420.0 COG4301@1|root,arCOG06722@2157|Archaea,41SWR@651137|Thaumarchaeota 651137|Thaumarchaeota S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 CMS1_k127_5359981_1 1229909.NSED_09025 5.171e-51 183.0 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - 2.7.13.3 ko:K07646,ko:K20989 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 2.A.21.6 - - DUF4118,GAF_3,KdpD,Usp CMS1_k127_5359981_3 698757.Pogu_1910 6.638e-15 75.0 COG3369@1|root,arCOG01667@2157|Archaea 2157|Archaea S Zinc finger CDGSH-type domain protein - - - - - - - - - - - - zf-CDGSH CMS1_k127_5359981_4 1229909.NSED_05370 9.384e-05 47.0 arCOG10955@1|root,arCOG10955@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_5359981_2 436308.Nmar_0743 9.098e-37 141.0 COG0011@1|root,arCOG04373@2157|Archaea,41T99@651137|Thaumarchaeota 651137|Thaumarchaeota S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP CMS1_k127_5359981_0 1229909.NSED_04040 6.944e-129 414.0 COG1060@1|root,arCOG00656@2157|Archaea,41SEG@651137|Thaumarchaeota 651137|Thaumarchaeota H Radical SAM - - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM CMS1_k127_5368569_2 1229909.NSED_06980 2.237e-109 355.0 COG0420@1|root,arCOG00397@2157|Archaea,41S68@651137|Thaumarchaeota 651137|Thaumarchaeota L Calcineurin-like phosphoesterase superfamily domain - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos_2 CMS1_k127_5368569_0 436308.Nmar_1243 8.62e-295 908.0 COG0433@1|root,arCOG00280@2157|Archaea,41SE3@651137|Thaumarchaeota 651137|Thaumarchaeota L Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - DUF87 CMS1_k127_5368569_1 436308.Nmar_1242 6.552e-155 491.0 COG1630@1|root,arCOG00367@2157|Archaea,41SJX@651137|Thaumarchaeota 651137|Thaumarchaeota L NurA - - - - - - - - - - - - NurA CMS1_k127_5368569_3 436308.Nmar_1010 9.633e-26 109.0 arCOG07473@1|root,arCOG07473@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_5371479_0 436308.Nmar_1782 9.321e-117 380.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 CMS1_k127_5371479_2 436308.Nmar_1781 8.95e-59 209.0 COG1514@1|root,arCOG01736@2157|Archaea,41SP7@651137|Thaumarchaeota 651137|Thaumarchaeota J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase CMS1_k127_5371479_1 1229909.NSED_09535 2.417e-85 286.0 COG0237@1|root,arCOG01045@2157|Archaea,41SI8@651137|Thaumarchaeota 651137|Thaumarchaeota H AAA domain - - - - - - - - - - - - AAA_17 CMS1_k127_5371479_3 436308.Nmar_1779 3.925e-43 161.0 COG1931@1|root,arCOG01043@2157|Archaea,41SRJ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0201 family - - - ko:K09736 - - - - ko00000 - - - RNA_binding CMS1_k127_5371479_5 1229909.NSED_09525 1.232e-06 54.0 arCOG08685@1|root,arCOG08685@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_5371479_4 1131266.ARWQ01000014_gene82 2.395e-16 79.0 COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota 651137|Thaumarchaeota K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 CMS1_k127_541078_2 1229909.NSED_01080 1.04e-42 162.0 COG0317@1|root,arCOG06870@2157|Archaea 2157|Archaea KT HD domain - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - HD_4 CMS1_k127_541078_1 436308.Nmar_0765 3.703e-72 245.0 COG1259@1|root,arCOG01759@2157|Archaea,41SQI@651137|Thaumarchaeota 651137|Thaumarchaeota S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase CMS1_k127_541078_0 436308.Nmar_0764 4.529e-285 885.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH CMS1_k127_5415588_2 1229909.NSED_06250 2.634e-07 53.0 arCOG10955@1|root,arCOG10955@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_5415588_1 314275.MADE_000001021140 3.614e-09 63.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4642R@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains yfhA GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS1_k127_5415588_0 1229909.NSED_05505 9.719e-74 258.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon CMS1_k127_5415588_3 1229909.NSED_05320 9.344e-07 54.0 arCOG08805@1|root,arCOG08805@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_541676_0 436308.Nmar_0517 8.589e-129 413.0 COG1405@1|root,arCOG01981@2157|Archaea,41S8Y@651137|Thaumarchaeota 651137|Thaumarchaeota K factor TFIIB - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon CMS1_k127_541676_3 436308.Nmar_0518 1.871e-33 130.0 COG3277@1|root,arCOG02466@2157|Archaea,41SVG@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA-binding protein involved in rRNA processing - - - ko:K07569 - - - - ko00000,ko03009 - - - Gar1 CMS1_k127_541676_1 436308.Nmar_0519 6.409e-46 167.0 COG1400@1|root,arCOG01217@2157|Archaea,41SR5@651137|Thaumarchaeota 651137|Thaumarchaeota U SRP19 protein - - - ko:K03105 ko03060,map03060 - - - ko00000,ko00001,ko02044 3.A.5.7,3.A.5.9 - - SRP19 CMS1_k127_541676_2 1229909.NSED_02615 5.605e-35 134.0 COG2007@1|root,arCOG04154@2157|Archaea,41SP2@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein S8e rps8e - - ko:K02995 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8e CMS1_k127_5452290_2 436308.Nmar_1393 2.213e-59 207.0 COG0164@1|root,arCOG04121@2157|Archaea,41SK9@651137|Thaumarchaeota 651137|Thaumarchaeota L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII CMS1_k127_5452290_1 1163730.FFONT_1218 5.93e-64 230.0 COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota 28889|Crenarchaeota J Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA flpA GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259 - ko:K04795 - - - - ko00000,ko03009 - - - Fibrillarin CMS1_k127_5452290_0 436308.Nmar_1391 3.021e-177 564.0 COG1498@1|root,arCOG01923@2157|Archaea,41SY9@651137|Thaumarchaeota 651137|Thaumarchaeota J NOSIC (NUC001) domain - - - ko:K14564 ko03008,map03008 - - - ko00000,ko00001,ko03009 - - - Nop CMS1_k127_5454874_3 1229909.NSED_05720 7.226e-09 61.0 arCOG08754@1|root,arCOG08754@2157|Archaea,41SUV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5454874_0 1229909.NSED_03865 2.177e-118 396.0 arCOG08796@1|root,arCOG08796@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_5454874_1 1229909.NSED_07700 8.298e-25 111.0 COG1522@1|root,arCOG01580@2157|Archaea,41T24@651137|Thaumarchaeota 651137|Thaumarchaeota K COG1522 Transcriptional regulators - - - - - - - - - - - - - CMS1_k127_5454874_2 436308.Nmar_0369 1.516e-23 101.0 COG1063@1|root,arCOG01459@2157|Archaea 2157|Archaea C Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N,Glu_dehyd_C CMS1_k127_5492248_2 436308.Nmar_1285 1.255e-33 132.0 COG0715@1|root,arCOG01803@2157|Archaea,41SG5@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 CMS1_k127_5492248_0 436308.Nmar_1284 1.292e-137 440.0 COG1116@1|root,arCOG00193@2157|Archaea,41S6Q@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type nitrate sulfonate bicarbonate transport system, ATPase component - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran CMS1_k127_5492248_1 1131266.ARWQ01000004_gene1447 7.567e-115 373.0 COG0600@1|root,arCOG00169@2157|Archaea,41SIT@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC-type nitrate sulfonate bicarbonate transport system, permease component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 CMS1_k127_5494831_0 1229909.NSED_05405 1.858e-304 937.0 COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA polymerase - - 2.7.7.7 ko:K02319 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032 - - - DNA_pol_B,DNA_pol_B_exo1 CMS1_k127_5505876_1 436308.Nmar_1368 6.331e-127 409.0 COG0457@1|root,arCOG03038@2157|Archaea,41SMV@651137|Thaumarchaeota 651137|Thaumarchaeota S Transglutaminase-like superfamily - - - - - - - - - - - - TPR_9,Transglut_core2 CMS1_k127_5505876_3 436308.Nmar_1369 3.167e-23 99.0 arCOG08651@1|root,arCOG08651@2157|Archaea,41TB6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5505876_2 1229909.NSED_07500 1.936e-26 108.0 arCOG10403@1|root,arCOG10403@2157|Archaea,41TB3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5505876_0 1459636.NTE_01565 6.882e-157 503.0 COG0475@1|root,arCOG01955@2157|Archaea,41SG1@651137|Thaumarchaeota 2157|Archaea P Sodium hydrogen exchanger - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger CMS1_k127_5511664_0 1229909.NSED_04460 8.17e-130 418.0 COG0092@1|root,arCOG04097@2157|Archaea,41SIM@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds the lower part of the 30S subunit head rps3 - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C CMS1_k127_5511664_2 1229909.NSED_04455 7.154e-27 110.0 COG0255@1|root,arCOG00785@2157|Archaea,41SV8@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the universal ribosomal protein uL29 family rpl29 - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 CMS1_k127_5511664_3 436308.Nmar_0802 1.322e-25 108.0 COG1588@1|root,arCOG00784@2157|Archaea,41TB4@651137|Thaumarchaeota 651137|Thaumarchaeota J Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends rnp1 - 3.1.26.5 ko:K03538 ko03008,ko03013,map03008,map03013 - - - ko00000,ko00001,ko01000,ko03009,ko03016,ko03029 - - - UPF0086 CMS1_k127_5511664_1 1229909.NSED_04445 2.547e-46 168.0 COG0186@1|root,arCOG04096@2157|Archaea,41SSH@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rps17 - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 CMS1_k127_5513969_2 436308.Nmar_1282 1.036e-22 101.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_5513969_1 436308.Nmar_0702 7.594e-57 200.0 arCOG06712@1|root,arCOG06712@2157|Archaea 2157|Archaea T PAS domain - - - - - - - - - - - - HATPase_c,PAS_4,PAS_9 CMS1_k127_5513969_3 436308.Nmar_0702 0.0004857 43.0 arCOG06712@1|root,arCOG06712@2157|Archaea 2157|Archaea T PAS domain - - - - - - - - - - - - HATPase_c,PAS_4,PAS_9 CMS1_k127_5513969_0 436308.Nmar_0701 2.617e-273 846.0 COG0365@1|root,arCOG04201@2157|Archaea 2157|Archaea I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS1_k127_5560036_4 1131266.ARWQ01000015_gene742 0.0001561 44.0 arCOG08747@1|root,arCOG08747@2157|Archaea,41T48@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5560036_2 1131266.ARWQ01000014_gene88 5.527e-76 260.0 COG0500@1|root,arCOG04347@2157|Archaea,41SQN@651137|Thaumarchaeota 651137|Thaumarchaeota Q Nodulation protein S (NodS) - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran CMS1_k127_5560036_1 1131266.ARWQ01000014_gene90 3.282e-97 322.0 COG1575@1|root,arCOG00480@2157|Archaea,41SNA@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the MenA family. Type 1 subfamily - - - - - - - - - - - - - CMS1_k127_5560036_3 1131266.ARWQ01000014_gene92 5.247e-51 184.0 COG0662@1|root,arCOG03003@2157|Archaea,41TAC@651137|Thaumarchaeota 651137|Thaumarchaeota G PFAM Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - CMS1_k127_5560036_0 436308.Nmar_0299 2.795e-297 914.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N CMS1_k127_5581738_0 436308.Nmar_1120 7.726e-273 845.0 COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 CMS1_k127_5601443_1 436308.Nmar_0827 1.648e-27 114.0 arCOG08721@1|root,arCOG08721@2157|Archaea,41SRS@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5601443_0 436308.Nmar_0828 3.138e-265 820.0 COG3425@1|root,arCOG01767@2157|Archaea,41SAQ@651137|Thaumarchaeota 651137|Thaumarchaeota I Hydroxymethylglutaryl-coenzyme A synthase N terminal - - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - HMG_CoA_synt_C,HMG_CoA_synt_N CMS1_k127_5601443_2 1229909.NSED_04560 4.73e-22 96.0 COG1651@1|root,arCOG02868@2157|Archaea,41T2A@651137|Thaumarchaeota 651137|Thaumarchaeota O DSBA-like thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 CMS1_k127_5616346_1 1229909.NSED_06265 7.903e-90 297.0 COG0440@1|root,arCOG04445@2157|Archaea,41SNS@651137|Thaumarchaeota 651137|Thaumarchaeota E acetolactate synthase, small - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C CMS1_k127_5616346_0 1229909.NSED_06260 6.147e-282 872.0 COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer CMS1_k127_5616346_2 1229909.NSED_06255 3.752e-87 290.0 COG0473@1|root,arCOG01163@2157|Archaea,41SAA@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS1_k127_5638210_2 436308.Nmar_0191 2.016e-28 114.0 arCOG08759@1|root,arCOG08759@2157|Archaea,41T9Q@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5638210_0 436308.Nmar_0192 1.138e-183 576.0 COG0115@1|root,arCOG02297@2157|Archaea,41SD5@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 CMS1_k127_5638210_3 1229909.NSED_00440 1.576e-22 98.0 arCOG11526@1|root,arCOG11526@2157|Archaea,41T9E@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5638210_1 436308.Nmar_0193 4.542e-104 340.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota 651137|Thaumarchaeota E Amino acid kinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase CMS1_k127_5641360_1 1229909.NSED_02485 2.028e-199 625.0 COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufD - - - ko:K09014,ko:K09015 - - - - ko00000 - - - UPF0051 CMS1_k127_5641360_2 1229909.NSED_02490 1.004e-47 173.0 COG2146@1|root,arCOG02852@2157|Archaea,41T71@651137|Thaumarchaeota 651137|Thaumarchaeota P of nitrite reductase and ring-hydroxylating - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske CMS1_k127_5641360_0 1229909.NSED_02495 1.102e-242 752.0 COG0520@1|root,arCOG00065@2157|Archaea,41SCV@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 CMS1_k127_5641360_3 1229909.NSED_02500 9.539e-45 162.0 COG0822@1|root,arCOG02077@2157|Archaea,41SPT@651137|Thaumarchaeota 651137|Thaumarchaeota C SUF system FeS assembly protein - - - ko:K04488 - - - - ko00000 - - - NifU_N CMS1_k127_56447_1 436308.Nmar_0973 6.495e-97 323.0 arCOG08728@1|root,arCOG08728@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_56447_0 436308.Nmar_0979 2.061e-112 370.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB CMS1_k127_56447_2 1229909.NSED_05655 5.965e-25 104.0 arCOG08662@1|root,arCOG08662@2157|Archaea 1229909.NSED_05655|- - - - - - - - - - - - - - - - CMS1_k127_5647221_3 436308.Nmar_0870 2.086e-26 109.0 COG0721@1|root,arCOG02726@2157|Archaea,41TB1@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) - - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - - CMS1_k127_5647221_0 436308.Nmar_0871 3.459e-253 784.0 COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota 651137|Thaumarchaeota J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) - - 6.1.1.23 ko:K09759 ko00970,map00970 M00360 R03647,R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon CMS1_k127_5647221_4 1229909.NSED_04885 8.162e-23 99.0 arCOG11517@1|root,arCOG11517@2157|Archaea,41TAE@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5647221_1 436308.Nmar_0872 2.37e-186 586.0 COG1759@1|root,arCOG04346@2157|Archaea,41SBR@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates purP - 6.3.4.23 ko:K06863 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R06975 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - DUF1246,DUF1297 CMS1_k127_5647221_5 1229909.NSED_01660 3.469e-07 58.0 arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS1_k127_5647221_2 1229909.NSED_04895 1.051e-53 189.0 COG3639@1|root,arCOG00173@2157|Archaea,41SZI@651137|Thaumarchaeota 651137|Thaumarchaeota P phosphonate ABC transporter, inner membrane subunit - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 CMS1_k127_5717188_3 1229909.NSED_02180 1.296e-35 136.0 COG1478@1|root,arCOG02714@2157|Archaea,41SHA@651137|Thaumarchaeota 651137|Thaumarchaeota H F420-0:Gamma-glutamyl ligase - - - - - - - - - - - - F420_ligase CMS1_k127_5717188_0 436308.Nmar_0418 1.624e-104 341.0 arCOG04033@1|root,arCOG04033@2157|Archaea,41SM5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5717188_2 436308.Nmar_0417 6.541e-52 184.0 arCOG10524@1|root,arCOG10524@2157|Archaea,41SVP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5717188_1 1229909.NSED_02165 1.743e-77 262.0 arCOG08663@1|root,arCOG08663@2157|Archaea,41SR2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5726645_1 436308.Nmar_0680 2.219e-143 457.0 COG2897@1|root,arCOG02019@2157|Archaea,41SBN@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese CMS1_k127_5726645_0 1229909.NSED_03420 1.114e-186 588.0 COG0457@1|root,arCOG03032@2157|Archaea,41SBD@651137|Thaumarchaeota 651137|Thaumarchaeota S TPR repeat - - - - - - - - - - - - TPR_1,TPR_2,TPR_8 CMS1_k127_5726645_2 436308.Nmar_0682 1.313e-33 132.0 arCOG03606@1|root,arCOG03606@2157|Archaea,41T15@651137|Thaumarchaeota 651137|Thaumarchaeota S Collagen triple helix repeat (20 copies) - - - - - - - - - - - - Collagen CMS1_k127_5781004_0 1229909.NSED_08170 1.652e-123 396.0 arCOG08638@1|root,arCOG08638@2157|Archaea,41T08@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5781004_1 1229909.NSED_08175 1.242e-96 318.0 arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5781004_3 1229909.NSED_08180 6.285e-43 158.0 COG1522@1|root,arCOG01117@2157|Archaea,41ST7@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg CMS1_k127_5781004_2 436308.Nmar_1486 1.176e-70 240.0 COG2947@1|root,arCOG08640@2157|Archaea,41SK6@651137|Thaumarchaeota 651137|Thaumarchaeota S EVE domain - - - - - - - - - - - - EVE CMS1_k127_5781004_4 1229909.NSED_04345 1.534e-10 61.0 arCOG11733@1|root,arCOG11733@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_578578_2 436308.Nmar_0866 2.924e-13 69.0 COG0365@1|root,arCOG01529@2157|Archaea,41SZA@651137|Thaumarchaeota 651137|Thaumarchaeota I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS1_k127_578578_0 436308.Nmar_0865 1.2e-243 758.0 COG0436@1|root,arCOG01130@2157|Archaea 2157|Archaea E PFAM Aminotransferase class I and II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_578578_1 1229909.NSED_04825 2.398e-17 86.0 arCOG03912@1|root,arCOG06534@1|root,arCOG08038@1|root,arCOG03912@2157|Archaea,arCOG06534@2157|Archaea,arCOG08038@2157|Archaea 2157|Archaea S protein secretion by the type IV secretion system - - - - - - - - - - - - He_PIG,SHOCT CMS1_k127_5797025_0 436308.Nmar_1794 8.823e-278 859.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 CMS1_k127_5819553_0 436308.Nmar_1457 3.935e-139 447.0 arCOG01778@1|root,arCOG01778@2157|Archaea,41SXW@651137|Thaumarchaeota 651137|Thaumarchaeota Q O-methyltransferase - - - - - - - - - - - - Methyltransf_31 CMS1_k127_5819553_1 1229909.NSED_01005 2.079e-84 282.0 COG0586@1|root,arCOG03117@2157|Archaea,41SQ5@651137|Thaumarchaeota 651137|Thaumarchaeota S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc CMS1_k127_5819553_3 1229909.NSED_07240 2.197e-06 54.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1 CMS1_k127_5819553_2 1229909.NSED_04505 1.521e-18 89.0 COG2133@1|root,arCOG02796@2157|Archaea,41T0Q@651137|Thaumarchaeota 651137|Thaumarchaeota G Glucose sorbosone - - - - - - - - - - - - GSDH CMS1_k127_5846662_0 436308.Nmar_0537 1.03e-222 695.0 COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota 651137|Thaumarchaeota G phosphoglycerate mutase - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase CMS1_k127_5846662_1 1229909.NSED_02710 2.981e-202 633.0 COG1085@1|root,arCOG00422@2157|Archaea,41S6T@651137|Thaumarchaeota 651137|Thaumarchaeota C Galactose-1-phosphate uridyl transferase, N-terminal domain - - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_transf CMS1_k127_5846662_5 1229909.NSED_02715 3.525e-40 153.0 arCOG08683@1|root,arCOG08683@2157|Archaea,41SUM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5846662_4 436308.Nmar_0540 8.017e-57 201.0 COG0454@1|root,arCOG00826@2157|Archaea,41T2E@651137|Thaumarchaeota 651137|Thaumarchaeota K Acetyltransferase (GNAT) domain - - 2.3.1.4 ko:K00621 ko00520,map00520 - R02058 RC00004,RC00166 ko00000,ko00001,ko01000 - - - Acetyltransf_1 CMS1_k127_5846662_3 1229909.NSED_02725 7.052e-110 359.0 COG1208@1|root,arCOG00663@2157|Archaea,41SGT@651137|Thaumarchaeota 651137|Thaumarchaeota M Nucleotidyl transferase - - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase CMS1_k127_5846662_2 436308.Nmar_0542 2.771e-153 495.0 COG0351@1|root,arCOG00020@2157|Archaea,41SA1@651137|Thaumarchaeota 651137|Thaumarchaeota H Phosphomethylpyrimidine kinase - - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K21219 ko00730,ko01100,map00730,map01100 - R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko01000 - - - Phos_pyr_kin,ThiP_synth CMS1_k127_5891657_0 1229909.NSED_08520 2.179e-58 207.0 arCOG01995@1|root,arCOG01995@2157|Archaea,41T3M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - SpoIIM CMS1_k127_5891657_1 1229909.NSED_03670 1.265e-41 156.0 arCOG10535@1|root,arCOG10535@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_5891657_2 436308.Nmar_0712 2.061e-33 132.0 arCOG08660@1|root,arCOG08660@2157|Archaea,41T60@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5895971_0 1229909.NSED_03170 1.685e-279 880.0 arCOG08231@1|root,arCOG08231@2157|Archaea,41T6Q@651137|Thaumarchaeota 651137|Thaumarchaeota L Lamin Tail Domain - - - - - - - - - - - - LTD CMS1_k127_5917688_0 436308.Nmar_0980 6.992e-140 447.0 COG0012@1|root,arCOG00357@2157|Archaea,41S8X@651137|Thaumarchaeota 651137|Thaumarchaeota J GTPase of unknown function C-terminal - - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,MMR_HSR1_C,TGS CMS1_k127_5917688_2 436308.Nmar_0981 3.903e-40 152.0 arCOG05491@1|root,arCOG05491@2157|Archaea,41SVB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5917688_1 436308.Nmar_0982 3.379e-59 207.0 COG1832@1|root,arCOG04227@2157|Archaea,41SMT@651137|Thaumarchaeota 651137|Thaumarchaeota S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 CMS1_k127_5923302_0 1229909.NSED_03355 0.0 1019.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge CMS1_k127_5947463_0 1229909.NSED_09745 2.431e-218 685.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger CMS1_k127_5947463_3 1229909.NSED_09750 5.209e-86 287.0 COG3945@1|root,arCOG01471@2157|Archaea,41T45@651137|Thaumarchaeota 651137|Thaumarchaeota S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin CMS1_k127_5947463_4 453591.Igni_0968 8.161e-38 148.0 COG0529@1|root,arCOG01040@2157|Archaea,2XQ81@28889|Crenarchaeota 28889|Crenarchaeota F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase CMS1_k127_5947463_1 1229909.NSED_09760 3.656e-143 457.0 COG0483@1|root,arCOG01349@2157|Archaea,41T8P@651137|Thaumarchaeota 651137|Thaumarchaeota G Inositol monophosphatase - - 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P CMS1_k127_5947463_5 1229909.NSED_09765 2.86e-30 120.0 arCOG08813@1|root,arCOG08813@2157|Archaea,41T88@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5947463_2 436308.Nmar_0026 4.232e-120 389.0 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_5948080_0 436308.Nmar_0332 2.081e-220 689.0 COG0053@1|root,arCOG01474@2157|Archaea,arCOG01475@2157|Archaea,41SXN@651137|Thaumarchaeota 651137|Thaumarchaeota P cation diffusion facilitator family transporter - - - - - - - - - - - - Cation_efflux,ZT_dimer CMS1_k127_5948080_1 1229909.NSED_01590 2.44e-79 268.0 COG0428@1|root,arCOG00576@2157|Archaea,41S6R@651137|Thaumarchaeota 651137|Thaumarchaeota P divalent heavy-metal cations transporter - - - - - - - - - - - - - CMS1_k127_594942_1 1229909.NSED_08945 2.61e-236 741.0 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD CMS1_k127_594942_4 436308.Nmar_1651 8.859e-77 262.0 arCOG08794@1|root,arCOG08794@2157|Archaea,41SR7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_594942_3 436308.Nmar_1650 9.557e-100 332.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind CMS1_k127_594942_2 1229909.NSED_08930 3.498e-111 366.0 arCOG10597@1|root,arCOG10597@2157|Archaea 2157|Archaea O serine-type endopeptidase activity - - - - - - - - - - - - - CMS1_k127_594942_0 1229909.NSED_08925 1.153e-277 862.0 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_5966264_1 1229909.NSED_00905 1.232e-81 280.0 arCOG07526@1|root,arCOG07526@2157|Archaea 2157|Archaea L Restriction endonuclease - - - - - - - - - - - - ATP-cone,Mrr_cat CMS1_k127_5966264_0 1459636.NTE_02862 1.631e-163 528.0 arCOG00144@1|root,arCOG00144@2157|Archaea 2157|Archaea S Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 CMS1_k127_5966264_2 436308.Nmar_0942 5.816e-28 114.0 COG0760@1|root,arCOG07441@2157|Archaea,41SSK@651137|Thaumarchaeota 651137|Thaumarchaeota O PPIC-type PPIASE domain - - 5.2.1.8 ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 CMS1_k127_6032936_1 1229909.NSED_09080 7.622e-90 299.0 COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD CMS1_k127_6032936_0 436308.Nmar_1705 3.291e-128 411.0 COG0528@1|root,arCOG00858@2157|Archaea,41T1R@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase CMS1_k127_6032936_2 1229909.NSED_09070 2.366e-50 181.0 arCOG08775@1|root,arCOG08775@2157|Archaea,41T9K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_6032936_3 1229909.NSED_09065 3.279e-12 70.0 arCOG03788@1|root,arCOG03788@2157|Archaea,41T96@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_6040146_1 1229909.NSED_01430 2.877e-226 706.0 COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota 651137|Thaumarchaeota E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N CMS1_k127_6040146_0 436308.Nmar_0295 0.0 1075.0 COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota 651137|Thaumarchaeota E RNase L inhibitor, RLI - - - ko:K06174 - - - - ko00000,ko03009 - - - ABC_tran,Fer4,RLI CMS1_k127_6040146_2 436308.Nmar_0294 1.121e-146 468.0 COG2520@1|root,arCOG00033@2157|Archaea,41S7P@651137|Thaumarchaeota 651137|Thaumarchaeota J Met-10+ like-protein - - 2.1.1.228 ko:K15429 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Met_10 CMS1_k127_6040146_4 1229909.NSED_01415 7.313e-31 123.0 COG5625@1|root,arCOG04189@2157|Archaea,41T7F@651137|Thaumarchaeota 651137|Thaumarchaeota K HTH DNA binding domain - - - - - - - - - - - - - CMS1_k127_6040146_3 436308.Nmar_0292 1.736e-90 299.0 COG0456@1|root,arCOG00833@2157|Archaea,41SIY@651137|Thaumarchaeota 651137|Thaumarchaeota K FR47-like protein - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 CMS1_k127_6040146_6 1229909.NSED_01405 1.355e-05 48.0 COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 CMS1_k127_6080740_0 436308.Nmar_0850 9.228e-117 379.0 arCOG07810@1|root,arCOG07810@2157|Archaea,41T26@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc CMS1_k127_6080740_1 436308.Nmar_0851 3.762e-45 166.0 arCOG10553@1|root,arCOG10553@2157|Archaea,41T8J@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_6080740_2 1229909.NSED_04695 1.808e-21 94.0 arCOG08684@1|root,arCOG08684@2157|Archaea,41T7E@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_6083085_2 1229909.NSED_04325 1.491e-55 194.0 COG0046@1|root,arCOG00641@2157|Archaea,41S6S@651137|Thaumarchaeota 651137|Thaumarchaeota F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS1_k127_6083085_0 1229909.NSED_04320 1.319e-132 424.0 COG0047@1|root,arCOG00102@2157|Archaea,41SG3@651137|Thaumarchaeota 651137|Thaumarchaeota F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 CMS1_k127_6083085_3 436308.Nmar_0778 2.452e-52 188.0 COG0517@1|root,arCOG00606@2157|Archaea,41SRY@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS CMS1_k127_6083085_4 436308.Nmar_0777 2.185e-41 154.0 COG1828@1|root,arCOG04462@2157|Archaea,41STY@651137|Thaumarchaeota 651137|Thaumarchaeota F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - PurS CMS1_k127_6083085_6 1229909.NSED_05370 1.145e-06 51.0 arCOG10955@1|root,arCOG10955@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_6083085_1 436308.Nmar_0775 2.707e-69 237.0 arCOG08712@1|root,arCOG08712@2157|Archaea,41SU6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_6083085_7 1229909.NSED_04305 0.0007427 42.0 COG0805@1|root,arCOG01919@2157|Archaea,41S69@651137|Thaumarchaeota 651137|Thaumarchaeota U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC CMS1_k127_6106765_1 436308.Nmar_1271 2.674e-76 265.0 COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS CMS1_k127_6106765_2 1229909.NSED_06550 9.892e-44 164.0 arCOG08634@1|root,arCOG08634@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_6106765_0 1229909.NSED_06555 1.052e-103 338.0 COG0221@1|root,arCOG01711@2157|Archaea,41T3F@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase CMS1_k127_6106765_4 1229909.NSED_06560 1.679e-34 133.0 arCOG06790@1|root,arCOG06790@2157|Archaea,41T7J@651137|Thaumarchaeota 651137|Thaumarchaeota S Zn-finger in ubiquitin-hydrolases and other protein - - - - - - - - - - - - zf-UBP CMS1_k127_6106765_3 1229909.NSED_02975 5.125e-41 154.0 COG0517@1|root,arCOG00606@2157|Archaea,41T8N@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS CMS1_k127_6124442_3 1229909.NSED_06980 1.691e-70 242.0 COG0420@1|root,arCOG00397@2157|Archaea,41S68@651137|Thaumarchaeota 651137|Thaumarchaeota L Calcineurin-like phosphoesterase superfamily domain - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos_2 CMS1_k127_6124442_0 436308.Nmar_1245 1.93e-301 938.0 COG0419@1|root,COG1122@1|root,arCOG00202@2157|Archaea,arCOG00368@2157|Archaea,41S9P@651137|Thaumarchaeota 651137|Thaumarchaeota LP AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15 CMS1_k127_6124442_5 1229909.NSED_08935 1.118e-18 100.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind CMS1_k127_6124442_1 1229909.NSED_06400 8.596e-163 530.0 COG3794@1|root,arCOG08764@1|root,arCOG02926@2157|Archaea,arCOG08764@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind CMS1_k127_6124442_6 1123059.KB823011_gene1000 7.309e-05 55.0 2DSXQ@1|root,33HVC@2|Bacteria,1N9KU@1224|Proteobacteria,2TWFA@28211|Alphaproteobacteria,43YJZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Kazal type serine protease inhibitors - - - - - - - - - - - - Kazal_1 CMS1_k127_6124442_2 436308.Nmar_1251 2.544e-88 292.0 arCOG04006@1|root,arCOG04006@2157|Archaea,41SKF@651137|Thaumarchaeota 651137|Thaumarchaeota C PBS lyase HEAT-like repeat - - 1.14.99.29 ko:K06072 - - - - ko00000,ko01000 - - - HEAT_2 CMS1_k127_6124442_4 436308.Nmar_1252 5.491e-44 160.0 arCOG08717@1|root,arCOG08717@2157|Archaea,41SFQ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - AhpC-TSA CMS1_k127_6136171_0 436308.Nmar_0389 3.312e-51 184.0 arCOG02709@1|root,arCOG02709@2157|Archaea 2157|Archaea S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase CMS1_k127_6143233_6 1229909.NSED_00730 8.113e-16 77.0 COG0131@1|root,arCOG04398@2157|Archaea,41SGY@651137|Thaumarchaeota 651137|Thaumarchaeota E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD CMS1_k127_6143233_5 1229909.NSED_00725 1.068e-135 438.0 COG0546@1|root,arCOG04692@2157|Archaea,41SJ6@651137|Thaumarchaeota 651137|Thaumarchaeota S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2,Hydrolase CMS1_k127_6143233_3 1229909.NSED_00720 1.241e-183 579.0 COG0079@1|root,arCOG04273@2157|Archaea,41SGB@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM Aminotransferase class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS1_k127_6143233_2 1229909.NSED_00715 2.025e-189 599.0 COG0141@1|root,arCOG04352@2157|Archaea,41S6J@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh CMS1_k127_6143233_1 1229909.NSED_00710 6.965e-195 609.0 COG0040@1|root,arCOG02208@2157|Archaea,41SCJ@651137|Thaumarchaeota 651137|Thaumarchaeota E ATP phosphoribosyltransferase - - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C CMS1_k127_6143233_0 1229909.NSED_00705 1.688e-212 665.0 COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the HMG-CoA reductase family - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red CMS1_k127_6143233_4 1229909.NSED_00700 1.429e-165 524.0 COG2133@1|root,arCOG02796@2157|Archaea,41S7F@651137|Thaumarchaeota 651137|Thaumarchaeota G Glucose sorbosone - - - - - - - - - - - - GSDH CMS1_k127_6149696_1 1229909.NSED_09785 1.096e-54 196.0 arCOG10512@1|root,arCOG10512@2157|Archaea,41T3J@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_6149696_0 1229909.NSED_09780 3.404e-89 298.0 COG5491@1|root,arCOG00452@2157|Archaea,41SYC@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - CMS1_k127_6149696_2 1229909.NSED_09775 1.259e-42 160.0 arCOG08814@1|root,arCOG08814@2157|Archaea,41T9Z@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_6184669_2 436308.Nmar_1713 1.185e-35 138.0 COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran CMS1_k127_6184669_0 436308.Nmar_1714 7.361e-222 691.0 COG4591@1|root,arCOG02313@2157|Archaea,41TBB@651137|Thaumarchaeota 651137|Thaumarchaeota M FtsX-like permease family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD CMS1_k127_6184669_1 436308.Nmar_1715 8.583e-118 383.0 COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota 651137|Thaumarchaeota K AsnC-type helix-turn-helix domain - - - - - - - - - - - - HTH_24 CMS1_k127_6211065_1 1229909.NSED_07450 3.548e-110 362.0 COG0475@1|root,arCOG01956@2157|Archaea 2157|Archaea P Sodium hydrogen exchanger - - - - - - - - - - - - CBS,Na_H_Exchanger CMS1_k127_6211065_0 1229909.NSED_09500 3.386e-118 391.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel CMS1_k127_6220941_0 1229909.NSED_00810 5.891e-22 98.0 COG0640@1|root,arCOG00731@2157|Archaea,41T40@651137|Thaumarchaeota 651137|Thaumarchaeota K Bacterial regulatory protein, arsR family - - - - - - - - - - - - HTH_5 CMS1_k127_6252723_1 1229909.NSED_04855 6.489e-255 791.0 COG0154@1|root,arCOG01717@2157|Archaea,41SCW@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase CMS1_k127_6252723_0 436308.Nmar_0868 1.211e-259 804.0 COG0064@1|root,arCOG01718@2157|Archaea,41S9S@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey CMS1_k127_6252723_2 436308.Nmar_0867 1.278e-28 116.0 arCOG10556@1|root,arCOG10556@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_6252723_3 1229909.NSED_04840 1.321e-13 70.0 COG0365@1|root,arCOG01529@2157|Archaea,41SZA@651137|Thaumarchaeota 651137|Thaumarchaeota I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS1_k127_6257930_1 1131266.ARWQ01000001_gene1349 1.857e-47 175.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N CMS1_k127_6257930_0 1365176.N186_01385 7.816e-132 432.0 COG0213@1|root,arCOG02013@2157|Archaea,2XPZT@28889|Crenarchaeota 28889|Crenarchaeota F Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO - - 2.4.2.57 ko:K18931 - - R10836,R10837,R10838 RC00063 ko00000,ko01000 - - - CDC48_N,Glycos_trans_3N,Glycos_transf_3,PYNP_C CMS1_k127_631109_3 1229909.NSED_03265 4.028e-65 225.0 COG2084@1|root,arCOG00247@2157|Archaea,41SI2@651137|Thaumarchaeota 651137|Thaumarchaeota I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 CMS1_k127_631109_1 1229909.NSED_03260 1.484e-139 445.0 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS1_k127_631109_2 1131266.ARWQ01000006_gene258 2.463e-68 237.0 COG1628@1|root,arCOG00928@2157|Archaea,41SMQ@651137|Thaumarchaeota 651137|Thaumarchaeota L Protein of unknown function DUF99 - - - ko:K09120 - - - - ko00000 - - - DUF99 CMS1_k127_631109_4 1229909.NSED_03250 6.252e-28 113.0 arCOG08753@1|root,arCOG08753@2157|Archaea,41T9W@651137|Thaumarchaeota 651137|Thaumarchaeota C 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - CMS1_k127_631109_0 1229909.NSED_03245 8.136e-202 634.0 COG0644@1|root,arCOG00570@2157|Archaea,41S82@651137|Thaumarchaeota 651137|Thaumarchaeota C geranylgeranyl reductase - - 1.3.1.101,1.3.7.11 ko:K17830 ko00564,map00564 - R10325,R10326,R10331 RC03134 ko00000,ko00001,ko01000 - - - DAO,FAD_oxidored,Trp_halogenase CMS1_k127_633778_2 436308.Nmar_1088 3.194e-197 617.0 COG0464@1|root,arCOG01307@2157|Archaea,41SA4@651137|Thaumarchaeota 651137|Thaumarchaeota D AAA domain (Cdc48 subfamily) - - - - - - - - - - - - AAA,MIT,Vps4_C CMS1_k127_633778_1 436308.Nmar_1086 9.479e-215 670.0 COG0505@1|root,arCOG00064@2157|Archaea,41SF0@651137|Thaumarchaeota 651137|Thaumarchaeota E carbamoyl-phosphate synthase, small subunit carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase CMS1_k127_633778_3 436308.Nmar_1085 2.057e-06 49.0 COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota 651137|Thaumarchaeota E MGS-like domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS CMS1_k127_633778_0 436308.Nmar_1085 4.906e-283 874.0 COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota 651137|Thaumarchaeota E MGS-like domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS CMS1_k127_6535_1 1229909.NSED_05165 8.72e-50 178.0 COG0010@1|root,arCOG01700@2157|Archaea,41T03@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase CMS1_k127_6535_0 436308.Nmar_0926 6.51e-293 904.0 COG0441@1|root,arCOG00401@2157|Archaea,41S9K@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-II aminoacyl-tRNA synthetase family thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b CMS1_k127_66754_3 1229909.NSED_00365 3.573e-58 205.0 arCOG00516@1|root,arCOG00516@2157|Archaea,41T43@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate - - - - - - - - - - - - Putative_PNPOx CMS1_k127_66754_0 1229909.NSED_00360 1.72e-229 715.0 COG0436@1|root,arCOG01131@2157|Archaea,41S8G@651137|Thaumarchaeota 651137|Thaumarchaeota E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_1_2 CMS1_k127_66754_2 1229909.NSED_00350 1.48e-78 266.0 arCOG10517@1|root,arCOG10517@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_66754_1 1229909.NSED_00165 7.403e-80 275.0 COG1817@1|root,arCOG01395@2157|Archaea,41S8D@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF354) - - - ko:K09726 - - - - ko00000 - - - DUF354 CMS1_k127_67759_0 1229909.NSED_06375 1.646e-96 317.0 COG0608@1|root,arCOG00424@2157|Archaea,41SE2@651137|Thaumarchaeota 651137|Thaumarchaeota L DHHA1 domain - - - ko:K07463 - - - - ko00000 - - - DHHA1 CMS1_k127_67759_1 1229909.NSED_02125 1.102e-72 255.0 COG0517@1|root,arCOG00601@2157|Archaea 2157|Archaea C CBS domain - - - - - - - - - - - - - CMS1_k127_67759_4 751944.HALDL1_01525 8.354e-05 49.0 COG3205@1|root,arCOG08188@2157|Archaea,2XZXF@28890|Euryarchaeota,23XIS@183963|Halobacteria 183963|Halobacteria S Predicted membrane protein (DUF2061) - - - - - - - - - - - - DUF2061 CMS1_k127_67759_2 436308.Nmar_1002 2.428e-54 193.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_67759_3 1163617.SCD_n00754 4.507e-28 119.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2VHCH@28216|Betaproteobacteria 28216|Betaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA CMS1_k127_683186_8 1229909.NSED_09360 2.534e-16 78.0 arCOG08749@1|root,arCOG08749@2157|Archaea,41SRV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_683186_0 1229909.NSED_09440 1.96e-228 713.0 COG0004@1|root,arCOG04397@2157|Archaea,41SZ0@651137|Thaumarchaeota 651137|Thaumarchaeota P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp CMS1_k127_683186_4 436308.Nmar_0587 3.646e-40 151.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - DUF2226,P-II CMS1_k127_683186_3 1229909.NSED_09450 1.151e-61 218.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II CMS1_k127_683186_5 436308.Nmar_0589 7.909e-26 110.0 arCOG05565@1|root,arCOG05565@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_683186_6 1229909.NSED_09385 3.507e-23 99.0 arCOG08748@1|root,arCOG08748@2157|Archaea,41SV7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_683186_7 1229909.NSED_09390 3.556e-17 81.0 arCOG08748@1|root,arCOG08748@2157|Archaea,41TAF@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_683186_2 436308.Nmar_1760 1.439e-89 296.0 COG2453@1|root,arCOG03413@2157|Archaea,41SK5@651137|Thaumarchaeota 651137|Thaumarchaeota T Dual specificity phosphatase, catalytic domain - - 3.1.3.16,3.1.3.48 ko:K14165 - - - - ko00000,ko01000,ko01009 - - - DSPc CMS1_k127_683186_1 1131266.ARWQ01000010_gene30 1.125e-153 488.0 COG1180@1|root,arCOG00946@2157|Archaea,41SBZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM CMS1_k127_685100_0 1229909.NSED_07095 4.441e-108 354.0 COG0685@1|root,arCOG00475@2157|Archaea,41SNK@651137|Thaumarchaeota 651137|Thaumarchaeota E cytochrome-c peroxidase activity - - - - - - - - - - - - - CMS1_k127_685100_1 436308.Nmar_1265 1.054e-83 280.0 COG0494@1|root,arCOG01072@2157|Archaea,41STX@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX CMS1_k127_685100_2 436308.Nmar_1264 1.637e-21 94.0 COG2167@1|root,arCOG04177@2157|Archaea,41SUT@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eL39 family rpl39e - - ko:K02924 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L39 CMS1_k127_685100_3 1229909.NSED_07080 3.386e-10 60.0 COG2097@1|root,arCOG04473@2157|Archaea,41STQ@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the ribosomal protein L31e family rpl31e - - ko:K02910 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31e CMS1_k127_748216_1 436308.Nmar_1617 5.224e-25 105.0 COG0307@1|root,arCOG04713@2157|Archaea,41SKQ@651137|Thaumarchaeota 651137|Thaumarchaeota H riboflavin synthase, alpha - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding CMS1_k127_748216_0 1229909.NSED_00070 1.591e-227 719.0 COG1287@1|root,arCOG02044@2157|Archaea,41SBI@651137|Thaumarchaeota 651137|Thaumarchaeota G Oligosaccharyl transferase STT3 subunit - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 CMS1_k127_771794_8 1229909.NSED_09845 1.785e-40 152.0 COG0300@1|root,arCOG01263@2157|Archaea,41SXQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short CMS1_k127_771794_0 436308.Nmar_0043 1.443e-159 508.0 COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota 651137|Thaumarchaeota S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS1_k127_771794_2 436308.Nmar_0042 3.477e-131 421.0 COG1100@1|root,arCOG01225@2157|Archaea,41T0A@651137|Thaumarchaeota 651137|Thaumarchaeota S Conserved hypothetical ATP binding protein - - - ko:K06883 - - - - ko00000 - - - ATP_bind_1 CMS1_k127_771794_1 436308.Nmar_0041 3.327e-146 467.0 COG0083@1|root,arCOG01027@2157|Archaea,41S89@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N CMS1_k127_771794_5 436308.Nmar_0040 9.092e-115 373.0 COG0603@1|root,arCOG00039@2157|Archaea,41SGR@651137|Thaumarchaeota 651137|Thaumarchaeota H Queuosine biosynthesis protein QueC - - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC CMS1_k127_771794_11 1229909.NSED_09820 3.014e-22 99.0 arCOG08816@1|root,arCOG08816@2157|Archaea,41TAW@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_771794_6 436308.Nmar_0038 5.016e-99 325.0 COG0302@1|root,arCOG04542@2157|Archaea,41SGC@651137|Thaumarchaeota 651137|Thaumarchaeota H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI CMS1_k127_771794_3 436308.Nmar_0037 5.798e-122 394.0 COG0602@1|root,arCOG02173@2157|Archaea,41SGM@651137|Thaumarchaeota 651137|Thaumarchaeota O Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Radical_SAM CMS1_k127_771794_9 436308.Nmar_0036 6.271e-27 110.0 arCOG08815@1|root,arCOG08815@2157|Archaea,41T9N@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_771794_10 1229909.NSED_09800 1.348e-22 109.0 arCOG10414@1|root,arCOG10414@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_771794_4 436308.Nmar_0034 3.701e-119 391.0 COG2512@1|root,arCOG00374@2157|Archaea,41SUX@651137|Thaumarchaeota 651137|Thaumarchaeota K membrane-associated protein domain - - - - - - - - - - - - - CMS1_k127_771794_7 1229909.NSED_09790 1.963e-46 169.0 COG3432@1|root,arCOG01055@2157|Archaea,41T3P@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 CMS1_k127_777753_5 192952.MM_3282 5.154e-10 62.0 COG1199@1|root,arCOG00770@2157|Archaea,2XSWZ@28890|Euryarchaeota 28890|Euryarchaeota K COG1199 Rad3-related DNA helicases - - - - - - - - - - - - DEAD_2,Helicase_C_2,ResIII CMS1_k127_777753_6 43228.XP_007736451.1 0.0005274 48.0 2EIHR@1|root,2SNXH@2759|Eukaryota,3APB2@33154|Opisthokonta,3PEV9@4751|Fungi,3QXWX@4890|Ascomycota,20P0Q@147545|Eurotiomycetes 4751|Fungi S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 CMS1_k127_777753_3 1229909.NSED_05000 7.601e-24 102.0 arCOG11730@1|root,arCOG11730@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_777753_2 436308.Nmar_0891 4.114e-39 146.0 arCOG10560@1|root,arCOG10560@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_777753_1 436308.Nmar_0892 1.783e-44 167.0 arCOG10561@1|root,arCOG10561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_777753_0 1229909.NSED_09740 6.137e-98 323.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon CMS1_k127_863328_5 1229909.NSED_09885 9.732e-15 74.0 COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD CMS1_k127_863328_0 436308.Nmar_0053 6.594e-210 656.0 COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 CMS1_k127_863328_3 1229909.NSED_09900 4.161e-54 192.0 COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota 651137|Thaumarchaeota C Protein of unknown function DUF126 - - - ko:K09128 - - - - ko00000 - - - DUF126 CMS1_k127_863328_2 1131266.ARWQ01000010_gene27 5.744e-79 268.0 COG2078@1|root,arCOG01336@2157|Archaea,41SMG@651137|Thaumarchaeota 651137|Thaumarchaeota S AMMECR1 - - - ko:K09141 - - - - ko00000 - - - AMMECR1 CMS1_k127_863328_4 1229909.NSED_01055 1.739e-41 158.0 COG1656@1|root,arCOG04290@2157|Archaea,41T65@651137|Thaumarchaeota 651137|Thaumarchaeota S Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C CMS1_k127_863328_1 436308.Nmar_0055 3.681e-142 455.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA CMS1_k127_871014_1 1229909.NSED_09595 4.292e-55 194.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 CMS1_k127_871014_2 1229909.NSED_09590 5.449e-24 105.0 arCOG08808@1|root,arCOG08808@2157|Archaea,41T95@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_871014_0 436308.Nmar_1790 1.782e-315 966.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N CMS1_k127_876716_0 1229909.NSED_01600 1.973e-183 586.0 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_893597_0 1229909.NSED_07580 3.463e-126 406.0 COG3593@1|root,arCOG03235@2157|Archaea,41SZV@651137|Thaumarchaeota 651137|Thaumarchaeota L AAA ATPase domain - - - - - - - - - - - - AAA_15 CMS1_k127_893597_1 1229909.NSED_07575 1.686e-39 151.0 arCOG10583@1|root,arCOG10583@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS1_k127_912894_2 436308.Nmar_1119 1.73e-24 102.0 COG0151@1|root,arCOG04415@2157|Archaea,41SB3@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N CMS1_k127_912894_1 1294142.CINTURNW_0188 7.069e-28 119.0 COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,36JPF@31979|Clostridiaceae 186801|Clostridia H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family fthC - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig CMS1_k127_912894_0 436308.Nmar_1117 2.16e-156 496.0 COG2759@1|root,arCOG04538@2157|Archaea,41S6B@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C CMS1_k127_912894_3 1229909.NSED_06470 9.618e-24 102.0 COG3224@1|root,arCOG08661@2157|Archaea,41T7D@651137|Thaumarchaeota 651137|Thaumarchaeota S Antibiotic biosynthesis monooxygenase - - 1.14.99.57 ko:K21481 - - - - ko00000,ko01000 - - - ABM CMS1_k127_951089_2 1229909.NSED_00700 4.198e-52 187.0 COG2133@1|root,arCOG02796@2157|Archaea,41S7F@651137|Thaumarchaeota 651137|Thaumarchaeota G Glucose sorbosone - - - - - - - - - - - - GSDH CMS1_k127_951089_0 1229909.NSED_00695 9.624e-211 662.0 COG1571@1|root,arCOG01115@2157|Archaea,41S9G@651137|Thaumarchaeota 651137|Thaumarchaeota J ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA tiaS - 6.3.4.22 ko:K06932 - - - - ko00000,ko01000,ko03016 - - - DUF1743 CMS1_k127_951089_1 436308.Nmar_1563 9.467e-180 566.0 COG1736@1|root,arCOG04112@2157|Archaea,41SE0@651137|Thaumarchaeota 651137|Thaumarchaeota J Diphthamide biosynthesis - - 2.5.1.108 ko:K07561 - - R10455 RC00021,RC03180 ko00000,ko01000,ko03012 - - - Diphthamide_syn CMS1_k127_951089_3 1229909.NSED_00685 1.592e-34 134.0 arCOG05195@1|root,arCOG05195@2157|Archaea 2157|Archaea S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_6,TPR_8 CMS1_k127_969769_0 436308.Nmar_1331 2.411e-38 145.0 COG1475@1|root,arCOG01875@2157|Archaea 2157|Archaea K PFAM ParB domain protein nuclease - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc CMS1_k127_969769_3 351160.RCIX2474 3.836e-09 67.0 arCOG06717@1|root,arCOG06717@2157|Archaea,2Y1S1@28890|Euryarchaeota,2NA4U@224756|Methanomicrobia 224756|Methanomicrobia - - - - - - - - - - - - - - - CMS1_k127_969769_2 1236973.JCM9157_2253 7.145e-13 78.0 2ERNT@1|root,33J87@2|Bacteria,1VMAP@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - CMS1_k127_969769_1 6211.A0A068YIY8 1.231e-13 80.0 COG5023@1|root,KOG1374@2759|Eukaryota,38EF0@33154|Opisthokonta,3BAIB@33208|Metazoa,3CSWX@33213|Bilateria 33208|Metazoa Z microtubule nucleation TUBG2 GO:0000003,GO:0000070,GO:0000086,GO:0000166,GO:0000212,GO:0000226,GO:0000228,GO:0000242,GO:0000278,GO:0000280,GO:0000793,GO:0000794,GO:0000819,GO:0000922,GO:0000930,GO:0000931,GO:0001882,GO:0001883,GO:0003002,GO:0003006,GO:0003674,GO:0005198,GO:0005200,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005768,GO:0005813,GO:0005814,GO:0005815,GO:0005819,GO:0005827,GO:0005829,GO:0005856,GO:0005874,GO:0005876,GO:0005881,GO:0005929,GO:0006810,GO:0006996,GO:0007010,GO:0007017,GO:0007020,GO:0007049,GO:0007051,GO:0007052,GO:0007056,GO:0007057,GO:0007059,GO:0007088,GO:0007097,GO:0007098,GO:0007127,GO:0007143,GO:0007144,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007310,GO:0007312,GO:0007346,GO:0007389,GO:0008150,GO:0008274,GO:0008275,GO:0008608,GO:0009266,GO:0009581,GO:0009582,GO:0009605,GO:0009628,GO:0009794,GO:0009798,GO:0009950,GO:0009953,GO:0009987,GO:0009994,GO:0010389,GO:0010457,GO:0010564,GO:0012505,GO:0015630,GO:0016043,GO:0016048,GO:0017076,GO:0019001,GO:0019953,GO:0021700,GO:0022402,GO:0022406,GO:0022412,GO:0022414,GO:0022607,GO:0030030,GO:0030031,GO:0030154,GO:0031023,GO:0031109,GO:0031252,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032465,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032954,GO:0032991,GO:0033043,GO:0034622,GO:0035639,GO:0036064,GO:0036094,GO:0042802,GO:0042995,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044450,GO:0044463,GO:0044464,GO:0044703,GO:0044770,GO:0044772,GO:0044782,GO:0044839,GO:0045132,GO:0045177,GO:0045995,GO:0046785,GO:0046907,GO:0048285,GO:0048468,GO:0048469,GO:0048477,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0051179,GO:0051225,GO:0051234,GO:0051235,GO:0051239,GO:0051258,GO:0051276,GO:0051302,GO:0051304,GO:0051306,GO:0051316,GO:0051321,GO:0051606,GO:0051640,GO:0051641,GO:0051642,GO:0051647,GO:0051649,GO:0051651,GO:0051656,GO:0051657,GO:0051661,GO:0051663,GO:0051704,GO:0051726,GO:0051783,GO:0055037,GO:0060271,GO:0061842,GO:0061982,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070925,GO:0071840,GO:0072687,GO:0090306,GO:0097159,GO:0097367,GO:0097435,GO:0097708,GO:0097711,GO:0097730,GO:0098813,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:0140013,GO:0140014,GO:0140056,GO:1901265,GO:1901363,GO:1901987,GO:1901990,GO:1902412,GO:1902749,GO:1902850,GO:1903046,GO:1903047,GO:1903436,GO:2000026 - ko:K10389 ko05165,map05165 - - - ko00000,ko00001,ko03036,ko04812 - - - Tubulin,Tubulin_C CMS1_k127_971050_0 1229909.NSED_08890 3.97e-84 279.0 COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota 651137|Thaumarchaeota I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS1_k127_971050_2 1131266.ARWQ01000009_gene924 5.098e-44 164.0 COG1545@1|root,arCOG01285@2157|Archaea,41SQK@651137|Thaumarchaeota 651137|Thaumarchaeota V nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc CMS1_k127_971050_3 436308.Nmar_1629 9.355e-28 112.0 arCOG08792@1|root,arCOG08792@2157|Archaea,41SUG@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - CMS1_k127_971050_1 436308.Nmar_1628 5.439e-70 238.0 COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota 651137|Thaumarchaeota FK Anaerobic ribonucleoside-triphosphate reductase - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,HTH_20,NRDD CMS1_k127_990732_0 436308.Nmar_0911 6.855e-209 653.0 COG0147@1|root,arCOG02014@2157|Archaea,41S8W@651137|Thaumarchaeota 651137|Thaumarchaeota E component I - - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind CMS1_k127_990732_1 1229909.NSED_05110 1.358e-110 359.0 COG0512@1|root,arCOG00086@2157|Archaea,41SGV@651137|Thaumarchaeota 651137|Thaumarchaeota E Glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase CMS1_k127_990732_2 436308.Nmar_0913 1.772e-94 312.0 COG0547@1|root,arCOG02012@2157|Archaea,41SGG@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 ## 1360 queries scanned ## Total time (seconds): 12.049487113952637 ## Rate: 112.87 q/s