## Fri Nov  8 07:45:49 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS1_bin.91.fa -m mmseqs --itype genome -o CMS1_bin.91 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS1_bin.91 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
CMS1_k127_1008429_2	237368.SCABRO_01544	6.904e-30	134.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
CMS1_k127_1008429_3	221027.JO40_12055	2.376e-14	82.0	COG4254@1|root,COG4254@2|Bacteria,2J6X7@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS1_k127_1008429_1	926561.KB900618_gene117	1.435e-53	196.0	COG3341@1|root,COG3341@2|Bacteria,1UIS0@1239|Firmicutes,25EQZ@186801|Clostridia	186801|Clostridia	L	Caulimovirus viroplasmin	rnhA	-	-	ko:K06993	-	-	-	-	ko00000	-	-	-	Cauli_VI,RNase_H
CMS1_k127_1008429_0	215803.DB30_7567	1.797e-115	388.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,42Q01@68525|delta/epsilon subdivisions,2X5HS@28221|Deltaproteobacteria,2YY6U@29|Myxococcales	28221|Deltaproteobacteria	F	Phosphohydrolase-associated domain	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
CMS1_k127_1023094_0	247490.KSU1_C1601	2.76e-30	127.0	COG1596@1|root,COG1596@2|Bacteria,2IY24@203682|Planctomycetes	203682|Planctomycetes	M	COG1596 Periplasmic protein involved in polysaccharide export	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
CMS1_k127_1023094_3	1122222.AXWR01000044_gene2342	1.877e-14	89.0	COG0497@1|root,COG0497@2|Bacteria,1WNDW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Tubulin like	-	-	-	-	-	-	-	-	-	-	-	-	Tubulin_2
CMS1_k127_1023094_1	313603.FB2170_11381	1.283e-25	120.0	COG1520@1|root,COG1520@2|Bacteria,4NFA9@976|Bacteroidetes,1I4P5@117743|Flavobacteriia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2,PQQ_3
CMS1_k127_1025952_0	289376.THEYE_A1685	5.547e-146	474.0	COG0174@1|root,COG0174@2|Bacteria,3J0AS@40117|Nitrospirae	40117|Nitrospirae	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
CMS1_k127_1025952_1	1131269.AQVV01000004_gene596	2.126e-67	243.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
CMS1_k127_1025952_2	688269.Theth_0318	3.109e-09	62.0	COG1366@1|root,COG1366@2|Bacteria,2GDAN@200918|Thermotogae	200918|Thermotogae	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS1_k127_103062_2	1408439.JHXW01000001_gene1872	1.234e-19	100.0	COG3183@1|root,COG3183@2|Bacteria	2|Bacteria	L	HNH endonuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3578,DUF3883,HNH
CMS1_k127_103062_0	1121912.AUHD01000013_gene1006	0.0	1463.0	COG1204@1|root,COG1204@2|Bacteria,4NSUP@976|Bacteroidetes	976|Bacteroidetes	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
CMS1_k127_1052403_2	864565.HMPREF0379_1170	1.421e-54	199.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia	186801|Clostridia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
CMS1_k127_1052403_0	944480.ATUV01000001_gene1631	5.161e-80	274.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria,2M6MK@213113|Desulfurellales	28221|Deltaproteobacteria	H	Pterin binding enzyme	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
CMS1_k127_1052403_1	123214.PERMA_0164	1.515e-63	227.0	COG1189@1|root,COG1189@2|Bacteria,2G3MN@200783|Aquificae	200783|Aquificae	J	Ribosomal RNA methyltransferase RrmJ FtsJ	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
CMS1_k127_1053818_0	933262.AXAM01000126_gene962	1.331e-114	391.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS1_k127_1053818_4	635013.TherJR_1519	0.000119	49.0	COG5581@1|root,COG5581@2|Bacteria,1VERW@1239|Firmicutes,24NU7@186801|Clostridia,261QY@186807|Peptococcaceae	186801|Clostridia	M	PFAM PilZ domain	pilZ	-	-	-	-	-	-	-	-	-	-	-	PilZ,YcgR_2
CMS1_k127_1053818_1	338963.Pcar_0007	2.333e-94	320.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,43TUN@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CMS1_k127_1053818_2	517418.Ctha_1706	4.817e-58	218.0	COG0366@1|root,COG0366@2|Bacteria,1FDIM@1090|Chlorobi	1090|Chlorobi	G	SMART alpha amylase, catalytic sub domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
CMS1_k127_1058291_0	1265505.ATUG01000002_gene2399	0.0	3376.0	COG0236@1|root,COG0304@1|root,COG1028@1|root,COG2070@1|root,COG3321@1|root,COG4221@1|root,COG0236@2|Bacteria,COG0304@2|Bacteria,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,2MIK4@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,PS-DH,ketoacyl-synt
CMS1_k127_1058291_1	96561.Dole_0184	2.06e-31	124.0	COG1309@1|root,COG1309@2|Bacteria,1Q299@1224|Proteobacteria,42UP4@68525|delta/epsilon subdivisions,2WQF0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_1060452_0	886379.AEWI01000207_gene2419	5.021e-173	569.0	COG1203@1|root,COG1203@2|Bacteria,4NFZ0@976|Bacteroidetes,2FPYD@200643|Bacteroidia,3XKFK@558415|Marinilabiliaceae	976|Bacteroidetes	L	Type III restriction enzyme, res subunit	-	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD,HD,Helicase_C,ResIII
CMS1_k127_1060452_3	880073.Calab_1312	1.242e-63	227.0	28NN3@1|root,2ZBNI@2|Bacteria	2|Bacteria	S	CRISPR-associated protein Cas5	cas5h	-	-	ko:K19116	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas5d
CMS1_k127_1060452_2	886379.AEWI01000004_gene864	1.187e-100	337.0	COG3649@1|root,COG3649@2|Bacteria,4NIKJ@976|Bacteroidetes,2FSN1@200643|Bacteroidia,3XKPG@558415|Marinilabiliaceae	976|Bacteroidetes	L	CRISPR-associated protein Cas7	-	-	-	ko:K19115	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas7
CMS1_k127_1060452_1	880073.Calab_1310	2.848e-109	376.0	28JMD@1|root,2Z9DX@2|Bacteria	2|Bacteria	-	-	csh	-	-	ko:K19114	-	-	-	-	ko00000,ko02048	-	-	-	-
CMS1_k127_1060452_4	747365.Thena_0814	1.297e-17	84.0	COG1583@1|root,COG1583@2|Bacteria,1TRPW@1239|Firmicutes,24A33@186801|Clostridia,42FEF@68295|Thermoanaerobacterales	186801|Clostridia	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA)	cas6	-	-	ko:K19091	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas6
CMS1_k127_1065780_4	269799.Gmet_2709	1.455e-83	295.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N1S@68525|delta/epsilon subdivisions,2WK7R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	mcp40H-21	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1
CMS1_k127_1065780_1	269799.Gmet_2710	4.458e-188	611.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WIRT@28221|Deltaproteobacteria,43T72@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	ATP-binding region, ATPase domain protein	cheA4	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
CMS1_k127_1065780_2	323848.Nmul_A0334	1.433e-114	379.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VPEC@28216|Betaproteobacteria,374K6@32003|Nitrosomonadales	28216|Betaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K13491	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
CMS1_k127_1065780_6	296591.Bpro_1814	5.879e-74	271.0	COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2WGZ0@28216|Betaproteobacteria	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,SBP_bac_3,dCache_1
CMS1_k127_1065780_7	883.DvMF_2543	1.522e-43	162.0	COG0745@1|root,COG0745@2|Bacteria,1PDU9@1224|Proteobacteria,43EXZ@68525|delta/epsilon subdivisions,2X2IY@28221|Deltaproteobacteria,2MD8C@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS1_k127_1065780_5	883.DvMF_2541	8.901e-77	288.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
CMS1_k127_1065780_3	177437.HRM2_34270	8.257e-92	315.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,2MHYS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
CMS1_k127_1065780_0	927658.AJUM01000047_gene2767	7.652e-221	689.0	COG0133@1|root,COG0133@2|Bacteria,4NDWP@976|Bacteroidetes,2G0EH@200643|Bacteroidia,3XIXC@558415|Marinilabiliaceae	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS1_k127_106645_3	1321815.HMPREF9193_00520	0.0001126	50.0	2BNWK@1|root,32HKH@2|Bacteria,2J9F2@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_106645_0	706434.HMPREF9429_00131	2.081e-32	141.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,4H4HE@909932|Negativicutes	909932|Negativicutes	M	Peptidase, M23 family	envC_2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS1_k127_106645_1	1217705.F900_02394	1.494e-29	126.0	2FC5I@1|root,3449C@2|Bacteria,1QN74@1224|Proteobacteria,1TKNS@1236|Gammaproteobacteria,3NJWW@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_106645_2	743722.Sph21_2706	8.316e-09	59.0	2APBA@1|root,31EDH@2|Bacteria,4NPIT@976|Bacteroidetes,1ITA2@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
CMS1_k127_1069172_0	635013.TherJR_0230	2.597e-174	559.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,260CD@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
CMS1_k127_1069172_1	1121413.JMKT01000009_gene1990	2.677e-100	345.0	COG2204@1|root,COG5002@1|root,COG2204@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MHC1@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7,PAS_8,PAS_9,Response_reg,SBP_bac_3,sCache_3_2
CMS1_k127_1085554_0	1167006.UWK_00694	1.913e-100	364.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
CMS1_k127_1085554_1	880071.Fleli_1083	0.0006531	44.0	2E5QE@1|root,330EY@2|Bacteria,4NWDY@976|Bacteroidetes,47WZ3@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1092340_1	1196322.A370_04885	9.436e-48	178.0	COG3501@1|root,COG3501@2|Bacteria,1UEX0@1239|Firmicutes,25JWE@186801|Clostridia,36QUM@31979|Clostridiaceae	186801|Clostridia	M	Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
CMS1_k127_1092340_2	1145276.T479_09705	2.608e-19	91.0	2CB7K@1|root,341D1@2|Bacteria,1VXX4@1239|Firmicutes,4HXN1@91061|Bacilli,3IYBP@400634|Lysinibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1092340_4	56110.Oscil6304_1054	8.694e-09	59.0	COG0656@1|root,COG0656@2|Bacteria,1G6K0@1117|Cyanobacteria	1117|Cyanobacteria	T	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Ntox11
CMS1_k127_1092340_3	446469.Sked_12420	1.682e-11	74.0	2EIM6@1|root,33CCG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1092340_0	1408473.JHXO01000009_gene3404	6.587e-102	341.0	COG1615@1|root,COG1615@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
CMS1_k127_1092590_1	96561.Dole_1932	8.818e-50	187.0	COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria,2MHMP@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,Hydrolase_4
CMS1_k127_1092590_2	907348.TresaDRAFT_0127	2.892e-23	108.0	2BRMP@1|root,32KM3@2|Bacteria,2J6W4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
CMS1_k127_1092590_0	573413.Spirs_2144	2.173e-294	923.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS1_k127_1102459_2	357804.Ping_1907	2.273e-76	265.0	COG0454@1|root,COG0456@2|Bacteria,1RA90@1224|Proteobacteria,1SAYV@1236|Gammaproteobacteria,2QJ16@267894|Psychromonadaceae	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.264	ko:K21935	-	-	R11701	-	ko00000,ko01000	-	-	-	Acetyltransf_1
CMS1_k127_1102459_1	331678.Cphamn1_1649	3.506e-233	726.0	COG1509@1|root,COG1509@2|Bacteria,1FEZW@1090|Chlorobi	1090|Chlorobi	H	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	LAM_C,Radical_SAM
CMS1_k127_1102459_3	398512.JQKC01000001_gene2076	2.729e-46	171.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,3WJHQ@541000|Ruminococcaceae	186801|Clostridia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
CMS1_k127_1102459_4	926559.JoomaDRAFT_0462	8.765e-38	145.0	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,1I2XY@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
CMS1_k127_1102459_6	1191523.MROS_0792	1.102e-10	65.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
CMS1_k127_1102459_0	394503.Ccel_0746	2.203e-308	964.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
CMS1_k127_1102459_5	572544.Ilyop_1495	4.812e-30	121.0	COG1937@1|root,COG1937@2|Bacteria,37AWC@32066|Fusobacteria	32066|Fusobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
CMS1_k127_1102584_0	889378.Spiaf_0836	1.934e-103	346.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_1102584_2	1123376.AUIU01000011_gene924	1.972e-61	218.0	COG0118@1|root,COG0118@2|Bacteria,3J0K7@40117|Nitrospirae	40117|Nitrospirae	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
CMS1_k127_1102584_1	1444310.JANV01000012_gene4286	2.328e-64	225.0	COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,4HCFG@91061|Bacilli,1ZBVJ@1386|Bacillus	91061|Bacilli	E	imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS14130	IGPD
CMS1_k127_1102763_0	1304885.AUEY01000005_gene802	2.492e-60	214.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42N6I@68525|delta/epsilon subdivisions,2WK7S@28221|Deltaproteobacteria,2MHYT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
CMS1_k127_1102763_2	332101.JIBU02000026_gene2928	4.667e-05	52.0	COG0457@1|root,COG0457@2|Bacteria,1UG0P@1239|Firmicutes,24KTB@186801|Clostridia,36K8Z@31979|Clostridiaceae	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
CMS1_k127_1102763_1	398512.JQKC01000016_gene2759	5.401e-52	190.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,3WIUM@541000|Ruminococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
CMS1_k127_1103322_0	309803.CTN_0411	2.143e-127	418.0	COG0282@1|root,COG0282@2|Bacteria,2GC1D@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
CMS1_k127_1103322_1	1124982.MSI_22460	1.331e-24	120.0	COG0741@1|root,COG0741@2|Bacteria,2J7A5@203691|Spirochaetes	203691|Spirochaetes	M	transglycosylase	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_6
CMS1_k127_1103462_0	945713.IALB_0315	5.378e-47	176.0	COG0632@1|root,COG0632@2|Bacteria	2|Bacteria	L	four-way junction helicase activity	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
CMS1_k127_1103462_1	247156.NFA_11020	6.242e-10	67.0	COG1695@1|root,COG1695@2|Bacteria,2IG8U@201174|Actinobacteria,4FYC8@85025|Nocardiaceae	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
CMS1_k127_1104411_1	1121405.dsmv_2039	3.38e-88	295.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,42PF5@68525|delta/epsilon subdivisions,2WMD8@28221|Deltaproteobacteria,2MIX9@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NADPH-dependent FMN reductase	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0771	FMN_red
CMS1_k127_1104411_0	123214.PERMA_1582	3.644e-179	568.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
CMS1_k127_1104411_2	1278307.KB906987_gene4201	3.298e-21	99.0	COG0569@1|root,COG0569@2|Bacteria,1QZBR@1224|Proteobacteria,1T44X@1236|Gammaproteobacteria,2QIHV@267894|Psychromonadaceae	1236|Gammaproteobacteria	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
CMS1_k127_1115123_1	889378.Spiaf_2848	1.627e-23	106.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2,zinc_ribbon_2
CMS1_k127_1115123_0	7668.SPU_028745-tr	2.075e-35	144.0	COG0666@1|root,COG5273@1|root,KOG0504@2759|Eukaryota,KOG0509@2759|Eukaryota,KOG4177@2759|Eukaryota,KOG4412@2759|Eukaryota,38BVK@33154|Opisthokonta,3BGGV@33208|Metazoa,3CT1S@33213|Bilateria	33208|Metazoa	M	ankyrin 3, node of Ranvier (ankyrin G)	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,ZU5
CMS1_k127_1115123_2	391596.PBAL39_02462	1.193e-12	73.0	COG2126@1|root,COG2126@2|Bacteria,4NEX1@976|Bacteroidetes,1IR8M@117747|Sphingobacteriia	976|Bacteroidetes	J	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
CMS1_k127_113404_1	469381.Dpep_2381	5.637e-09	66.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF11,DUF4114,Lactonase,Phage-tail_3
CMS1_k127_113404_0	1121085.AUCI01000007_gene1221	5.422e-119	417.0	COG0745@1|root,COG4251@1|root,COG5002@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1UMIM@1239|Firmicutes,4ITVY@91061|Bacilli,1ZSDG@1386|Bacillus	91061|Bacilli	T	7TMR-DISM extracellular 2	-	-	-	ko:K20971	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Response_reg
CMS1_k127_1136191_2	240015.ACP_0162	5.463e-35	143.0	COG0682@1|root,COG0682@2|Bacteria,3Y4QQ@57723|Acidobacteria,2JJ7E@204432|Acidobacteriia	204432|Acidobacteriia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS1_k127_1136191_3	860228.Ccan_14570	1.325e-26	115.0	2E6GM@1|root,3313V@2|Bacteria,4NT39@976|Bacteroidetes,1IICB@117743|Flavobacteriia,1ES73@1016|Capnocytophaga	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1136191_0	526224.Bmur_1917	9.514e-76	277.0	COG2604@1|root,COG2604@2|Bacteria,2J5P0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
CMS1_k127_1136191_1	865861.AZSU01000003_gene1944	5.772e-58	214.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,36DJT@31979|Clostridiaceae	186801|Clostridia	M	stage V sporulation protein D	spoVD	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
CMS1_k127_1136905_0	941824.TCEL_00325	0.0	1249.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
CMS1_k127_1136905_1	439235.Dalk_2512	3.66e-63	221.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2MI64@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS1_k127_116127_0	521460.Athe_0548	2.169e-292	911.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,42ET1@68295|Thermoanaerobacterales	186801|Clostridia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Glutaredoxin,NRDD
CMS1_k127_116127_4	1123371.ATXH01000015_gene1650	1.341e-12	68.0	COG1328@1|root,COG1328@2|Bacteria,2GI4Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Anaerobic ribonucleoside-triphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	NRDD
CMS1_k127_116127_3	658659.HMPREF0983_01494	5.089e-55	200.0	COG1180@1|root,COG1846@1|root,COG1180@2|Bacteria,COG1846@2|Bacteria,1V1GP@1239|Firmicutes,3VP52@526524|Erysipelotrichia	526524|Erysipelotrichia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,MarR,MarR_2,Radical_SAM
CMS1_k127_116127_2	697281.Mahau_0729	9.482e-73	252.0	COG0454@1|root,COG0456@2|Bacteria,1V40T@1239|Firmicutes,250X6@186801|Clostridia	186801|Clostridia	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_116127_1	96561.Dole_2961	9.438e-147	469.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2MIP5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM PhoH-like protein	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
CMS1_k127_117390_1	1192034.CAP_6891	1.558e-07	56.0	COG1193@1|root,COG1193@2|Bacteria,1NCS6@1224|Proteobacteria,42VGJ@68525|delta/epsilon subdivisions,2WRA6@28221|Deltaproteobacteria,2YVNG@29|Myxococcales	28221|Deltaproteobacteria	L	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
CMS1_k127_117390_0	935836.JAEL01000046_gene4138	1.215e-20	101.0	COG1193@1|root,COG1193@2|Bacteria,1TQWB@1239|Firmicutes,4HAHW@91061|Bacilli,1ZC6C@1386|Bacillus	91061|Bacilli	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS1	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V
CMS1_k127_120712_1	1121904.ARBP01000004_gene881	3.169e-165	527.0	COG0111@1|root,COG0111@2|Bacteria,4NDVN@976|Bacteroidetes,47MQ2@768503|Cytophagia	976|Bacteroidetes	EH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS1_k127_120712_0	1121904.ARBP01000004_gene880	3.059e-168	534.0	COG1932@1|root,COG1932@2|Bacteria,4NE06@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
CMS1_k127_120712_2	1313304.CALK_0665	3.701e-49	183.0	COG2344@1|root,COG2344@2|Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS1_k127_120712_3	585.DR95_428	8.183e-07	57.0	COG0589@1|root,COG0589@2|Bacteria,1RI97@1224|Proteobacteria,1S5Z1@1236|Gammaproteobacteria,3Z2Y5@583|Proteus	1236|Gammaproteobacteria	T	Universal stress protein	-	-	-	ko:K14061	-	-	-	-	ko00000	-	-	-	Usp
CMS1_k127_1225621_3	269797.Mbar_B3746	1.65e-23	102.0	COG1817@1|root,arCOG01395@2157|Archaea,2XUV1@28890|Euryarchaeota,2NAHQ@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	-
CMS1_k127_1225621_0	304371.MCP_0766	3.793e-92	314.0	COG0463@1|root,arCOG00896@2157|Archaea,2XT4C@28890|Euryarchaeota,2N9AQ@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_1225621_1	1291050.JAGE01000001_gene2501	2.368e-28	117.0	COG4584@1|root,COG4584@2|Bacteria,1TR5X@1239|Firmicutes,24BGR@186801|Clostridia,3WRXI@541000|Ruminococcaceae	186801|Clostridia	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
CMS1_k127_1225621_2	192952.MM_2685	4.411e-25	105.0	COG1484@1|root,arCOG06699@2157|Archaea	192952.MM_2685|-	L	DNA-dependent DNA replication	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1225621_4	269797.Mbar_A2139	1.7e-06	50.0	COG2244@1|root,arCOG02209@2157|Archaea,2Y663@28890|Euryarchaeota,2NB3M@224756|Methanomicrobia	224756|Methanomicrobia	S	MviN-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
CMS1_k127_1257927_0	368407.Memar_1142	3.276e-91	309.0	COG0731@1|root,arCOG00953@2157|Archaea,2XUIN@28890|Euryarchaeota,2NB0A@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
CMS1_k127_1257927_3	754027.HMPREF9554_01175	8.894e-08	61.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS1_k127_1257927_1	1304880.JAGB01000001_gene872	7.357e-70	246.0	COG1142@1|root,COG2878@1|root,COG1142@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia	186801|Clostridia	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
CMS1_k127_1257927_2	580340.Tlie_0075	2.013e-57	213.0	COG1536@1|root,COG1536@2|Bacteria,3TACV@508458|Synergistetes	508458|Synergistetes	N	flagellar motor switch protein FliG	-	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
CMS1_k127_1275512_5	1480694.DC28_04465	4.166e-36	144.0	arCOG05203@1|root,31A0K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1275512_2	511051.CSE_12370	4.317e-47	172.0	COG0432@1|root,COG0432@2|Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	yugU	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS1_k127_1275512_4	1307761.L21SP2_3186	2.779e-36	147.0	2C8AB@1|root,2ZW6G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1275512_3	1307761.L21SP2_3187	8.198e-37	147.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
CMS1_k127_1275512_0	861299.J421_2922	2.666e-74	260.0	COG0568@1|root,COG0568@2|Bacteria,1ZSR6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS1_k127_1275512_8	1124982.MSI_20680	1.226e-09	70.0	2C8R1@1|root,2ZG03@2|Bacteria,2J6QN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1275512_1	387092.NIS_0674	7.351e-74	258.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2YP9I@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_1275512_10	1124780.ANNU01000030_gene1136	7.186e-05	53.0	COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,47MMF@768503|Cytophagia	976|Bacteroidetes	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
CMS1_k127_1275512_7	880073.Calab_2702	2.524e-21	104.0	COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CMS1_k127_1275512_6	765914.ThisiDRAFT_1953	1.735e-24	113.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1S0WJ@1236|Gammaproteobacteria,1WWFB@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
CMS1_k127_128118_1	694431.DESACE_07720	5.111e-24	110.0	COG1280@1|root,COG1280@2|Bacteria	2|Bacteria	E	homoserine transmembrane transporter activity	-	-	-	ko:K06895	-	-	-	-	ko00000,ko02000	2.A.75.1	-	-	LysE
CMS1_k127_128118_2	1089553.Tph_c10710	2.6e-22	108.0	COG0758@1|root,COG1846@1|root,COG0758@2|Bacteria,COG1846@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,42FQZ@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
CMS1_k127_128118_0	406124.ACPC01000019_gene3342	5.279e-56	204.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,4HB1H@91061|Bacilli,1ZAV8@1386|Bacillus	91061|Bacilli	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS1_k127_1298595_3	382464.ABSI01000012_gene2204	3.7e-33	141.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase,HemolysinCabind
CMS1_k127_1298595_1	398512.JQKC01000041_gene4142	2.496e-106	354.0	COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1TTAX@1239|Firmicutes,24BT9@186801|Clostridia,3WKH7@541000|Ruminococcaceae	186801|Clostridia	K	Bacterial transcription activator, effector binding domain	-	-	-	ko:K13652	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18,HTH_AraC
CMS1_k127_1298595_2	1122919.KB905576_gene3389	2.146e-84	286.0	COG3363@1|root,COG3363@2|Bacteria,1TRA7@1239|Firmicutes,4HURJ@91061|Bacilli,26RB6@186822|Paenibacillaceae	91061|Bacilli	F	IMP cyclohydrolase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	IMP_cyclohyd
CMS1_k127_1298595_0	903818.KI912269_gene319	1.041e-136	449.0	COG1785@1|root,COG1785@2|Bacteria	2|Bacteria	P	alkaline phosphatase activity	phoA	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
CMS1_k127_1307221_0	1123376.AUIU01000011_gene973	7.242e-60	223.0	COG0265@1|root,COG0265@2|Bacteria,3J0VW@40117|Nitrospirae	40117|Nitrospirae	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS1_k127_1318392_2	588581.Cpap_2738	3.18e-105	352.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,3WIID@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
CMS1_k127_1318392_4	768710.DesyoDRAFT_1924	3.848e-80	274.0	COG1120@1|root,COG1120@2|Bacteria,1UYT8@1239|Firmicutes,24CJY@186801|Clostridia	186801|Clostridia	HP	Abc transporter	-	-	3.6.3.34	ko:K02013,ko:K09820	ko02010,map02010	M00240,M00243	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.15	-	-	ABC_tran
CMS1_k127_1318392_3	1121289.JHVL01000050_gene2002	1.9e-90	310.0	COG0614@1|root,COG0614@2|Bacteria,1TQ11@1239|Firmicutes,2482R@186801|Clostridia,36E5P@31979|Clostridiaceae	186801|Clostridia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS1_k127_1318392_7	335541.Swol_1688	4.713e-53	194.0	COG0500@1|root,COG2226@2|Bacteria,1V7SG@1239|Firmicutes,24AEB@186801|Clostridia	186801|Clostridia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS1_k127_1318392_6	694427.Palpr_0499	3.829e-64	244.0	COG1629@1|root,COG4771@2|Bacteria,4NFQD@976|Bacteroidetes,2G3H3@200643|Bacteroidia	976|Bacteroidetes	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
CMS1_k127_1318392_5	485916.Dtox_3476	2.08e-74	259.0	COG1720@1|root,COG1720@2|Bacteria	2|Bacteria	S	tRNA m6t6A37 methyltransferase activity	virR	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	UPF0066
CMS1_k127_1318392_1	1476973.JMMB01000007_gene225	8.124e-110	367.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,25R1M@186804|Peptostreptococcaceae	186801|Clostridia	E	cysteine desulfurase family protein	csd2	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS1_k127_1318392_8	1123371.ATXH01000030_gene2020	3.621e-19	100.0	COG0811@1|root,COG0811@2|Bacteria,2GIHG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CMS1_k127_1318392_9	596324.TREVI0001_1767	7.368e-19	92.0	COG0848@1|root,COG0848@2|Bacteria,2J7UG@203691|Spirochaetes	203691|Spirochaetes	U	protein, ExbD TolR family	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
CMS1_k127_1318392_12	1499967.BAYZ01000136_gene30	1.114e-07	60.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_2,TonB_C
CMS1_k127_1318392_0	385682.AFSL01000065_gene1629	0.0	1743.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,4NF4F@976|Bacteroidetes,2FKZU@200643|Bacteroidia,3XJQ5@558415|Marinilabiliaceae	976|Bacteroidetes	C	Domain of unknown function	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
CMS1_k127_1318392_10	857293.CAAU_2024	6.363e-14	78.0	COG1595@1|root,COG1595@2|Bacteria,1V3G9@1239|Firmicutes,24G1Y@186801|Clostridia	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_1318392_11	378806.STAUR_7454	2.645e-10	68.0	2BV42@1|root,32QH6@2|Bacteria,1MZ0Q@1224|Proteobacteria,42T0A@68525|delta/epsilon subdivisions,2WP4M@28221|Deltaproteobacteria,2YXD3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1320220_1	439235.Dalk_0273	4.938e-08	64.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core	-	-	-	-	-	-	-	-	-	-	-	-	AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
CMS1_k127_1320220_2	760192.Halhy_5040	1.854e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,4NGGZ@976|Bacteroidetes,1ITVZ@117747|Sphingobacteriia	976|Bacteroidetes	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
CMS1_k127_1320220_0	439235.Dalk_0859	3.355e-11	74.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core	-	-	-	-	-	-	-	-	-	-	-	-	AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
CMS1_k127_1352965_0	1408473.JHXO01000013_gene583	1.183e-173	554.0	COG1055@1|root,COG1055@2|Bacteria	2|Bacteria	P	arsenite transmembrane transporter activity	arsA	-	-	-	-	-	-	-	-	-	-	-	CitMHS
CMS1_k127_1352965_3	1408473.JHXO01000013_gene584	8.034e-56	198.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	ccpN	GO:0006355,GO:0007154,GO:0007584,GO:0008150,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0042221,GO:0045013,GO:0045892,GO:0045934,GO:0045990,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K02806,ko:K04767	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	CBS,HTH_11,NTP_transferase
CMS1_k127_1352965_1	1408473.JHXO01000013_gene585	3.497e-130	423.0	COG1105@1|root,COG1105@2|Bacteria,4NFZI@976|Bacteroidetes	976|Bacteroidetes	G	belongs to the carbohydrate kinase PfkB family	pfkB	-	2.7.1.11,2.7.1.144	ko:K00917,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
CMS1_k127_1352965_5	195103.CPF_0844	2.728e-25	108.0	COG4627@1|root,COG4627@2|Bacteria,1VACW@1239|Firmicutes,24NCH@186801|Clostridia,36NEC@31979|Clostridiaceae	186801|Clostridia	S	Stress responsive A B barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
CMS1_k127_1352965_4	411464.DESPIG_01057	5.268e-26	120.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria,2M7QN@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS1_k127_1352965_2	1191523.MROS_0684	5.346e-98	323.0	COG0588@1|root,COG0588@2|Bacteria	2|Bacteria	G	phosphoglycerate mutase activity	gpmA	GO:0001871,GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009986,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031,GO:2001065	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
CMS1_k127_1354071_1	1121403.AUCV01000020_gene3115	9.216e-120	398.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,2MINV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
CMS1_k127_1354071_0	237368.SCABRO_01577	1.06e-186	593.0	COG0498@1|root,COG0498@2|Bacteria,2IXKE@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS1_k127_1354071_2	1336234.JAGN01000013_gene189	1.179e-07	63.0	COG0681@1|root,COG0681@2|Bacteria,1V954@1239|Firmicutes,4HN7A@91061|Bacilli	91061|Bacilli	U	Belongs to the peptidase S26 family	lepB_2	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S26
CMS1_k127_136919_4	944480.ATUV01000001_gene1617	5.074e-19	94.0	COG1309@1|root,COG1309@2|Bacteria,1RCDH@1224|Proteobacteria,42VJ5@68525|delta/epsilon subdivisions,2WRC7@28221|Deltaproteobacteria,2M7F8@213113|Desulfurellales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_3,TetR_N
CMS1_k127_136919_5	197221.22294356	1.765e-05	57.0	COG1538@1|root,COG1538@2|Bacteria,1G0B8@1117|Cyanobacteria	1117|Cyanobacteria	MU	outer membrane efflux protein	-	-	-	ko:K03287	-	-	-	-	ko00000	1.B.17	-	-	OEP
CMS1_k127_136919_2	269799.Gmet_3464	2.248e-48	183.0	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43BPM@68525|delta/epsilon subdivisions,2X70W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
CMS1_k127_136919_1	1397528.Q671_16190	8.438e-87	296.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XHSS@135619|Oceanospirillales	135619|Oceanospirillales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_136919_0	247490.KSU1_D0847	1.676e-102	346.0	COG0842@1|root,COG0842@2|Bacteria,2J1QC@203682|Planctomycetes	203682|Planctomycetes	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
CMS1_k127_136919_3	247490.KSU1_D0848	1.867e-37	148.0	COG0842@1|root,COG0842@2|Bacteria,2IYZA@203682|Planctomycetes	203682|Planctomycetes	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
CMS1_k127_137592_6	1046714.AMRX01000003_gene82	9.836e-10	59.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,465Y3@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS1_k127_137592_7	86416.Clopa_4407	4.203e-09	66.0	COG0664@1|root,COG0664@2|Bacteria,1V3XW@1239|Firmicutes,24HXX@186801|Clostridia,36VUG@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914,ko:K21563	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_137592_4	926567.TheveDRAFT_0439	3.872e-13	81.0	COG1868@1|root,COG1868@2|Bacteria,3TA6T@508458|Synergistetes	508458|Synergistetes	N	TIGRFAM flagellar motor switch protein FliM	-	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
CMS1_k127_137592_8	1209989.TepiRe1_1344	0.0001605	53.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,24821@186801|Clostridia,42F05@68295|Thermoanaerobacterales	186801|Clostridia	NTU	TIGRFAM flagellar motor switch protein FliN	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C
CMS1_k127_137592_2	693661.Arcve_1438	1.729e-23	109.0	COG1213@1|root,arCOG00673@2157|Archaea,2XZD0@28890|Euryarchaeota,24723@183980|Archaeoglobi	183980|Archaeoglobi	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
CMS1_k127_137592_3	1163730.FFONT_0114	5.823e-20	98.0	COG0637@1|root,arCOG02293@2157|Archaea	2157|Archaea	S	HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_137592_0	382464.ABSI01000022_gene480	9.125e-58	212.0	COG4714@1|root,COG4714@2|Bacteria,46WYQ@74201|Verrucomicrobia,2IUN8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF2167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2167
CMS1_k127_137592_1	1121373.KB903628_gene1432	2.412e-51	189.0	COG0705@1|root,COG0705@2|Bacteria,4NECA@976|Bacteroidetes,47PXT@768503|Cytophagia	976|Bacteroidetes	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS1_k127_137592_5	1219035.NT2_04_00890	1.843e-11	69.0	COG3326@1|root,COG3326@2|Bacteria,1NGR5@1224|Proteobacteria,2UJDY@28211|Alphaproteobacteria,2KBEU@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1294
CMS1_k127_1377070_1	1123270.ATUR01000002_gene2442	0.0003295	52.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2TS6D@28211|Alphaproteobacteria,2K09Q@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
CMS1_k127_1377070_0	880072.Desac_0759	1.204e-153	495.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MCR@68525|delta/epsilon subdivisions,2WJXI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EK	PFAM aminotransferase class I and II	lysN	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
CMS1_k127_1402412_2	330214.NIDE4163	1.994e-06	54.0	COG0828@1|root,COG0828@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
CMS1_k127_1402412_1	945713.IALB_0734	5.321e-146	474.0	COG2256@1|root,COG2256@2|Bacteria	2|Bacteria	L	atpase related to the helicase subunit of the holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
CMS1_k127_1402412_3	1265505.ATUG01000002_gene2012	0.0001769	49.0	COG0457@1|root,COG0457@2|Bacteria,1R438@1224|Proteobacteria,42PQ9@68525|delta/epsilon subdivisions,2WJ0C@28221|Deltaproteobacteria,2MIBG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
CMS1_k127_1402412_0	1307761.L21SP2_1735	2.632e-161	541.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
CMS1_k127_1419418_3	688270.Celal_1303	1.257e-14	84.0	COG4886@1|root,COG4886@2|Bacteria,4NR6Y@976|Bacteroidetes,1I2WF@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Receptor L domain	-	-	-	-	-	-	-	-	-	-	-	-	Recep_L_domain
CMS1_k127_1419418_0	768670.Calni_0514	6.221e-212	664.0	COG0019@1|root,COG0019@2|Bacteria,2GF5Z@200930|Deferribacteres	200930|Deferribacteres	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS1_k127_1419418_1	1121129.KB903371_gene243	1.038e-180	569.0	COG0191@1|root,COG0191@2|Bacteria,4NF5C@976|Bacteroidetes,2FMMR@200643|Bacteroidia,22WHF@171551|Porphyromonadaceae	976|Bacteroidetes	G	Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
CMS1_k127_1419418_2	1117319.PSPO_03937	1.62e-76	262.0	28HV7@1|root,2Z81K@2|Bacteria,1R7FG@1224|Proteobacteria,1RR04@1236|Gammaproteobacteria,2Q0V4@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Surface lipoprotein of Spirochaetales order	-	-	-	-	-	-	-	-	-	-	-	-	Lipl32
CMS1_k127_149103_1	471854.Dfer_2735	4.63e-50	186.0	COG1136@1|root,COG1136@2|Bacteria,4NGDU@976|Bacteroidetes,47JS7@768503|Cytophagia	976|Bacteroidetes	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
CMS1_k127_149103_2	1121353.H924_01775	0.0001831	53.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,22KFP@1653|Corynebacteriaceae	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS1_k127_149103_0	269797.Mbar_A1385	3.6e-76	259.0	COG0655@1|root,arCOG02573@2157|Archaea,2XWPJ@28890|Euryarchaeota,2NAHI@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS1_k127_1492999_5	941824.TCEL_01487	2.788e-32	135.0	COG1183@1|root,COG1183@2|Bacteria,1TR44@1239|Firmicutes,24HHK@186801|Clostridia,36JIJ@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
CMS1_k127_1492999_6	1089548.KI783301_gene120	2.032e-31	125.0	COG0234@1|root,COG0234@2|Bacteria,1TTUJ@1239|Firmicutes,4I4J6@91061|Bacilli,3WF1D@539002|Bacillales incertae sedis	91061|Bacilli	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	-	-	-	-	-	-	-	-	-	-	-	Cpn10
CMS1_k127_1492999_0	1123274.KB899433_gene1339	2.028e-233	733.0	COG0459@1|root,COG0459@2|Bacteria,2J5CK@203691|Spirochaetes	203691|Spirochaetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
CMS1_k127_1492999_4	1528106.JRJE01000027_gene452	3.828e-99	333.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2TRRT@28211|Alphaproteobacteria,2JPZ6@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family 2	-	-	2.4.1.83,2.4.2.53	ko:K00721,ko:K10012	ko00510,ko00520,ko01100,ko01503,map00510,map00520,map01100,map01503	M00721,M00761	R01009,R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
CMS1_k127_1492999_3	344747.PM8797T_17549	8.788e-110	379.0	COG0793@1|root,COG0793@2|Bacteria,2IXI9@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
CMS1_k127_1492999_1	123214.PERMA_1486	8.742e-170	546.0	COG0154@1|root,COG0154@2|Bacteria,2G3JX@200783|Aquificae	200783|Aquificae	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
CMS1_k127_1492999_2	1094980.Mpsy_2456	5.031e-138	452.0	COG0415@1|root,arCOG02840@2157|Archaea,2XTVM@28890|Euryarchaeota,2NAIC@224756|Methanomicrobia	224756|Methanomicrobia	L	FAD binding domain of DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
CMS1_k127_1492999_8	1131730.BAVI_04339	6.465e-10	69.0	COG0664@1|root,COG0664@2|Bacteria,1V3XW@1239|Firmicutes,4HDG1@91061|Bacilli,1ZCQ7@1386|Bacillus	91061|Bacilli	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914,ko:K21828	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_1492999_7	1121335.Clst_1950	2.976e-11	66.0	COG0692@1|root,COG0692@2|Bacteria,1UUFM@1239|Firmicutes,256M9@186801|Clostridia,3WR39@541000|Ruminococcaceae	186801|Clostridia	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
CMS1_k127_1494588_7	644968.DFW101_2070	9.392e-18	83.0	COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2WPMI@28221|Deltaproteobacteria,2M96M@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
CMS1_k127_1494588_8	159087.Daro_1294	9.074e-16	90.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria,2KVQ8@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_1494588_3	203119.Cthe_2166	2.243e-29	132.0	COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,3WGCG@541000|Ruminococcaceae	186801|Clostridia	KT	stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_4,PAS_9,SpoIIE
CMS1_k127_1494588_0	1121405.dsmv_2187	4.391e-135	442.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42N9E@68525|delta/epsilon subdivisions,2WJAX@28221|Deltaproteobacteria,2MI1Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS1_k127_1494588_2	667014.Thein_0177	1.706e-34	140.0	COG1648@1|root,COG1648@2|Bacteria,2GH09@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Sirohaem biosynthesis protein central	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
CMS1_k127_1494588_1	237368.SCABRO_00408	5.159e-46	169.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS1_k127_1494588_5	1304885.AUEY01000111_gene2949	2.906e-25	106.0	COG4118@1|root,COG4118@2|Bacteria,1NP8X@1224|Proteobacteria,42XXG@68525|delta/epsilon subdivisions,2WWJ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
CMS1_k127_1494588_6	1192034.CAP_8763	5.918e-23	115.0	28M6Z@1|root,2ZAKH@2|Bacteria,1QZIK@1224|Proteobacteria,43CK2@68525|delta/epsilon subdivisions,2X7UH@28221|Deltaproteobacteria,2YUNR@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1494588_4	862908.BMS_2153	1.479e-25	119.0	COG2911@1|root,COG3210@1|root,COG3420@1|root,COG5295@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,COG5295@2|Bacteria,1NGFP@1224|Proteobacteria,43EIP@68525|delta/epsilon subdivisions,2MUTH@213481|Bdellovibrionales,2X8HE@28221|Deltaproteobacteria	213481|Bdellovibrionales	U	Chaperone of endosialidase	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Peptidase_S74
CMS1_k127_1507227_0	525897.Dbac_0704	1.525e-171	542.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2M8ZB@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_1507227_1	1116472.MGMO_4c00060	2.548e-25	112.0	COG3594@1|root,COG3594@2|Bacteria,1NK0N@1224|Proteobacteria,1SIF8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Acyltransferase family	gumG	-	-	ko:K13664	-	-	-	-	ko00000,ko01000	-	-	-	Acyl_transf_3
CMS1_k127_1518919_0	913865.DOT_2968	2.583e-107	360.0	COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia,260FF@186807|Peptococcaceae	186801|Clostridia	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
CMS1_k127_1518919_2	935948.KE386495_gene1030	8.756e-89	299.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,42FCC@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
CMS1_k127_1518919_3	1410633.JHWR01000006_gene1158	1.578e-63	227.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,27JMB@186928|unclassified Lachnospiraceae	186801|Clostridia	S	TIGR00268 family	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
CMS1_k127_1518919_1	237368.SCABRO_00008	9.936e-93	314.0	COG5464@1|root,COG5464@2|Bacteria,2J1E3@203682|Planctomycetes	203682|Planctomycetes	S	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_31
CMS1_k127_1518919_10	706191.PANA_0910	5.1e-05	49.0	COG1396@1|root,COG1396@2|Bacteria,1PGQB@1224|Proteobacteria,1TD7S@1236|Gammaproteobacteria,3W2F1@53335|Pantoea	1236|Gammaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_1518919_5	43989.cce_3860	3.198e-41	160.0	2CM5E@1|root,332ZW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1518919_4	1125725.HMPREF1325_2410	1.899e-45	167.0	COG4226@1|root,COG4226@2|Bacteria,2J8NR@203691|Spirochaetes	203691|Spirochaetes	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
CMS1_k127_1518919_6	1125725.HMPREF1325_2411	1.081e-11	65.0	2E9T0@1|root,333Z2@2|Bacteria	2|Bacteria	S	HicA toxin of bacterial toxin-antitoxin,	hicA	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS1_k127_1518919_9	880070.Cycma_4487	5.834e-07	52.0	2E9T0@1|root,333Z2@2|Bacteria,4NUQI@976|Bacteroidetes,47SUM@768503|Cytophagia	976|Bacteroidetes	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
CMS1_k127_1518919_8	509191.AEDB02000049_gene4423	2.311e-07	61.0	COG3209@1|root,COG3209@2|Bacteria,1UZR4@1239|Firmicutes,24CNR@186801|Clostridia,3WN51@541000|Ruminococcaceae	186801|Clostridia	M	Insecticide toxin TcdB middle/N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
CMS1_k127_1518919_11	103690.17130993	0.0004444	48.0	COG1409@1|root,COG1413@1|root,COG5635@1|root,COG1409@2|Bacteria,COG1413@2|Bacteria,COG5635@2|Bacteria,1G233@1117|Cyanobacteria,1HJ1W@1161|Nostocales	1117|Cyanobacteria	CT	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,NB-ARC,Peptidase_C14
CMS1_k127_1518919_7	710111.FraQA3DRAFT_0729	1.019e-09	69.0	COG3209@1|root,COG3209@2|Bacteria,2GK1D@201174|Actinobacteria,4EW27@85013|Frankiales	201174|Actinobacteria	M	TIGRFAM YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
CMS1_k127_1521209_6	323850.Shew_1184	4.018e-15	87.0	COG3637@1|root,COG3637@2|Bacteria,1RHUP@1224|Proteobacteria,1THET@1236|Gammaproteobacteria,2QD54@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Domain of unknown function (DUF3943)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3943,OMP_b-brl
CMS1_k127_1521209_3	1304888.ATWF01000001_gene2022	9.819e-40	153.0	COG0242@1|root,COG0242@2|Bacteria,2GFNS@200930|Deferribacteres	200930|Deferribacteres	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CMS1_k127_1521209_4	1072685.IX83_00985	1.397e-38	150.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria,3T3JW@506|Alcaligenaceae	28216|Betaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
CMS1_k127_1521209_2	1282887.AUJG01000018_gene2072	1.52e-71	252.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS1_k127_1521209_5	639282.DEFDS_1462	1.371e-33	132.0	COG1403@1|root,COG1403@2|Bacteria,2GFWA@200930|Deferribacteres	200930|Deferribacteres	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
CMS1_k127_1521209_0	526224.Bmur_1062	5.575e-93	335.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1521209_1	1304880.JAGB01000004_gene1471	7.702e-76	270.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,24CF8@186801|Clostridia	186801|Clostridia	F	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,DUF1343
CMS1_k127_1522373_0	314230.DSM3645_04265	1.605e-80	277.0	COG0040@1|root,COG0040@2|Bacteria,2IXEV@203682|Planctomycetes	203682|Planctomycetes	F	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
CMS1_k127_1522373_3	387092.NIS_1544	1.739e-24	106.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2YNQD@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Histidine biosynthesis bifunctional protein hisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
CMS1_k127_1522373_1	177437.HRM2_22230	1.301e-48	187.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42PHT@68525|delta/epsilon subdivisions,2WKTH@28221|Deltaproteobacteria,2MIBI@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS1_k127_1522373_2	123214.PERMA_0835	4.057e-36	152.0	COG3746@1|root,COG3746@2|Bacteria,2G5GY@200783|Aquificae	200783|Aquificae	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
CMS1_k127_1525317_0	1123037.AUDE01000009_gene1419	5.984e-79	275.0	COG4585@1|root,COG4585@2|Bacteria,4NI9U@976|Bacteroidetes,1HX1I@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,TPR_12,TPR_7
CMS1_k127_1525317_1	1469557.JSWF01000016_gene2236	2.152e-77	265.0	COG2197@1|root,COG2197@2|Bacteria,4NN0B@976|Bacteroidetes,1I0A6@117743|Flavobacteriia	976|Bacteroidetes	T	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS1_k127_1525317_2	1250005.PHEL85_1636	2.079e-41	156.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,1HWUW@117743|Flavobacteriia,3VV23@52959|Polaribacter	976|Bacteroidetes	O	Domain of unknown function (DUF5118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
CMS1_k127_152892_0	1121104.AQXH01000001_gene858	4.244e-11	70.0	COG1595@1|root,COG1595@2|Bacteria,4NT79@976|Bacteroidetes,1IZNZ@117747|Sphingobacteriia	976|Bacteroidetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_152892_1	1537994.JQFW01000003_gene3320	4.526e-08	54.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,1S67R@1236|Gammaproteobacteria,4678S@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG0784 FOG CheY-like receiver	cheY1	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
CMS1_k127_1542986_0	1480694.DC28_09300	4.3e-212	669.0	COG0326@1|root,COG0326@2|Bacteria,2J6JQ@203691|Spirochaetes	203691|Spirochaetes	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
CMS1_k127_1542986_1	316067.Geob_1634	2.312e-118	413.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,43TK1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
CMS1_k127_1542986_2	1117379.BABA_10906	2.73e-39	156.0	COG0437@1|root,COG0437@2|Bacteria,1TT2G@1239|Firmicutes,4HII4@91061|Bacilli,1ZDQF@1386|Bacillus	91061|Bacilli	C	COG0437 Fe-S-cluster-containing hydrogenase components 1	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_7
CMS1_k127_1563110_4	543913.D521_0195	3.169e-44	171.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,1KPPU@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS1_k127_1563110_8	861299.J421_3455	2.091e-08	59.0	COG1366@1|root,COG1366@2|Bacteria,1ZTXM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS1_k127_1563110_6	720554.Clocl_4104	8.972e-28	122.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,3WKFF@541000|Ruminococcaceae	186801|Clostridia	S	Phosphoribosyl transferase domain	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
CMS1_k127_1563110_3	1304885.AUEY01000032_gene1992	3.025e-81	276.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2MIYB@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
CMS1_k127_1563110_2	1307761.L21SP2_1779	2.945e-81	288.0	COG0772@1|root,COG0772@2|Bacteria,2J62H@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family. MrdB RodA subfamily	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
CMS1_k127_1563110_1	526224.Bmur_2504	3.56e-107	369.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
CMS1_k127_1563110_7	477974.Daud_1464	6.498e-09	63.0	COG2891@1|root,COG2891@2|Bacteria,1V1EJ@1239|Firmicutes,24RP5@186801|Clostridia,262R9@186807|Peptococcaceae	186801|Clostridia	M	shape-determining protein MreD	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
CMS1_k127_1563110_5	1045858.Bint_0519	6.329e-43	168.0	COG1792@1|root,COG1792@2|Bacteria,2J77U@203691|Spirochaetes	203691|Spirochaetes	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
CMS1_k127_1563110_0	526224.Bmur_1068	7.573e-139	448.0	COG1077@1|root,COG1077@2|Bacteria,2J59M@203691|Spirochaetes	203691|Spirochaetes	D	cell shape determining protein, MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
CMS1_k127_1571058_1	551115.Aazo_0517	4.765e-88	307.0	COG1216@1|root,COG1216@2|Bacteria,1G4M1@1117|Cyanobacteria,1HMVR@1161|Nostocales	1117|Cyanobacteria	S	Glycosyltransferase like family 2	-	-	2.4.1.288	ko:K16650	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glyco_tranf_2_3
CMS1_k127_1571058_3	1121479.AUBS01000031_gene126	3.165e-64	229.0	COG1216@1|root,COG2604@1|root,COG1216@2|Bacteria,COG2604@2|Bacteria,1R556@1224|Proteobacteria,2UB8N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,MAF_flag10
CMS1_k127_1571058_2	1207058.L53_01730	3.493e-83	282.0	COG1083@1|root,COG1083@2|Bacteria,1QACI@1224|Proteobacteria,2U5PV@28211|Alphaproteobacteria,43YYJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Cytidylyltransferase	-	-	2.7.7.43	ko:K00983	ko00520,ko01100,map00520,map01100	-	R01117,R04215	RC00152	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3
CMS1_k127_1571058_0	290315.Clim_1889	1.844e-92	310.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	-	-	1.1.1.215,1.1.1.26,1.1.1.28,1.1.1.399,1.1.1.79,1.1.1.81,1.1.1.95	ko:K00015,ko:K00058,ko:K00090,ko:K03778	ko00030,ko00260,ko00620,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00260,map00620,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00465,R00704,R00717,R01388,R01392,R01513,R01739	RC00031,RC00042,RC00044,RC00084	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS1_k127_1571058_4	537972.ABQU01000028_gene507	2.491e-35	140.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2YNZT@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS1_k127_157111_8	268407.PWYN_11055	3.097e-43	163.0	COG1680@1|root,COG1680@2|Bacteria,1V8KF@1239|Firmicutes,4HIEX@91061|Bacilli,26VFI@186822|Paenibacillaceae	91061|Bacilli	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
CMS1_k127_157111_16	1198452.Jab_1c24530	1.253e-06	59.0	COG3713@1|root,COG3713@2|Bacteria,1NCB9@1224|Proteobacteria,2VS6I@28216|Betaproteobacteria	2|Bacteria	M	Outer membrane protein V	-	-	-	ko:K07274	-	-	-	-	ko00000,ko02000	9.B.99.1	-	-	MipA
CMS1_k127_157111_20	1226322.HMPREF1545_02422	2.435e-05	51.0	28J53@1|root,2Z90Z@2|Bacteria,1UZB1@1239|Firmicutes,24EGW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_157111_17	1278073.MYSTI_05745	1.867e-06	51.0	COG4447@1|root,COG4447@2|Bacteria,1NR34@1224|Proteobacteria,43E2U@68525|delta/epsilon subdivisions,2WZJ3@28221|Deltaproteobacteria,2Z28Z@29|Myxococcales	28221|Deltaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_157111_1	926561.KB900617_gene1906	6.119e-153	502.0	COG0366@1|root,COG0366@2|Bacteria,1TP9E@1239|Firmicutes,248DX@186801|Clostridia	186801|Clostridia	G	Alpha-amylase domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26
CMS1_k127_157111_5	1120951.AUBG01000014_gene3181	2.731e-75	257.0	COG1357@1|root,COG1357@2|Bacteria,4NQ3B@976|Bacteroidetes,1I2VH@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Pentapeptide	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
CMS1_k127_157111_19	1289135.A966_03865	2.366e-05	57.0	COG0457@1|root,COG0457@2|Bacteria	1289135.A966_03865|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_157111_22	329726.AM1_2827	0.0001635	54.0	COG0457@1|root,COG0457@2|Bacteria,1G2WY@1117|Cyanobacteria	1117|Cyanobacteria	S	Seems to be required for the assembly of the photosystem I complex	ycf3	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_7,TPR_8
CMS1_k127_157111_6	357808.RoseRS_3316	4.639e-65	232.0	COG0483@1|root,COG0483@2|Bacteria,2G6JD@200795|Chloroflexi,375ER@32061|Chloroflexia	32061|Chloroflexia	G	PFAM inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS1_k127_157111_2	1304875.JAFZ01000001_gene1356	1.157e-143	467.0	COG0104@1|root,COG0104@2|Bacteria,3TA4C@508458|Synergistetes	508458|Synergistetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
CMS1_k127_157111_7	398512.JQKC01000032_gene4461	2.371e-55	197.0	COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,24HP8@186801|Clostridia,3WIK4@541000|Ruminococcaceae	186801|Clostridia	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
CMS1_k127_157111_9	504472.Slin_1191	7.703e-42	163.0	COG1409@1|root,COG1409@2|Bacteria,4NMZ0@976|Bacteroidetes,47PC2@768503|Cytophagia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos,Metallophos_2
CMS1_k127_157111_11	338963.Pcar_2756	1.216e-30	122.0	2E5UQ@1|root,330IY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_157111_12	391009.Tmel_1414	4.61e-27	114.0	COG3450@1|root,COG3450@2|Bacteria,2GDFM@200918|Thermotogae	200918|Thermotogae	S	Enzyme of the cupin superfamily	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
CMS1_k127_157111_10	665571.STHERM_c20320	4.406e-37	142.0	COG3323@1|root,COG3323@2|Bacteria,2J96M@203691|Spirochaetes	203691|Spirochaetes	L	Protein of unknown function (DUF1653)	glnK	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_157111_0	945713.IALB_1601	1.177e-198	633.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	sulP	GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	iSbBS512_1146.SbBS512_E1370	STAS,Sulfate_transp
CMS1_k127_157111_13	889378.Spiaf_0370	1.066e-23	109.0	2EFH0@1|root,3399K@2|Bacteria	2|Bacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
CMS1_k127_157111_3	1121335.Clst_0287	4.439e-113	379.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3WIA6@541000|Ruminococcaceae	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
CMS1_k127_157111_14	344747.PM8797T_23049	3.065e-23	111.0	2CBIH@1|root,33WXG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_157111_4	269799.Gmet_0873	4.997e-97	329.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,43SZM@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
CMS1_k127_157111_15	1125699.HMPREF9194_00224	5.064e-10	69.0	COG2885@1|root,COG3405@1|root,COG2885@2|Bacteria,COG3405@2|Bacteria,2JB4P@203691|Spirochaetes	203691|Spirochaetes	M	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1601930_2	1304284.L21TH_0877	5.626e-43	160.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,24NZG@186801|Clostridia,36VU4@31979|Clostridiaceae	186801|Clostridia	P	Ferric uptake regulator family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
CMS1_k127_1601930_3	395493.BegalDRAFT_1766	5.684e-21	95.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,4613Z@72273|Thiotrichales	72273|Thiotrichales	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
CMS1_k127_1601930_1	1230342.CTM_04848	2.731e-78	284.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EG9@31979|Clostridiaceae	186801|Clostridia	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_2
CMS1_k127_1601930_0	309807.SRU_0300	5.679e-206	668.0	COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1FJVJ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrd	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
CMS1_k127_1610643_0	1123274.KB899413_gene847	2.603e-141	462.0	COG1749@1|root,COG1749@2|Bacteria,2J5H4@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook protein flgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
CMS1_k127_1610643_4	906968.Trebr_1606	8.886e-25	111.0	COG1843@1|root,COG1843@2|Bacteria,2J806@203691|Spirochaetes	203691|Spirochaetes	N	flagellar hook	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
CMS1_k127_1610643_5	398512.JQKC01000007_gene1142	6.125e-13	81.0	COG3144@1|root,COG3144@2|Bacteria,1VAP1@1239|Firmicutes,24RF8@186801|Clostridia,3WMXB@541000|Ruminococcaceae	186801|Clostridia	N	PFAM Flagellar hook-length control	fliK	-	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
CMS1_k127_1610643_3	880073.Calab_0477	7.645e-66	229.0	COG0566@1|root,COG0566@2|Bacteria,2NQ0F@2323|unclassified Bacteria	2|Bacteria	J	tRNA rRNA methyltransferase	spoU	-	2.1.1.185	ko:K03218,ko:K03437	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	SpoU_methylase
CMS1_k127_1610643_2	573413.Spirs_1789	1.011e-92	312.0	COG4786@1|root,COG4786@2|Bacteria,2J5EJ@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein	flhO	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
CMS1_k127_1610643_1	1232410.KI421412_gene109	3.389e-135	443.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,43TD6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
CMS1_k127_1610643_6	945713.IALB_2148	1.546e-07	63.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cohesin,fn3
CMS1_k127_1610643_7	1408304.JAHA01000004_gene1024	2.355e-06	56.0	COG1595@1|root,COG1595@2|Bacteria,1VBYB@1239|Firmicutes,25BPK@186801|Clostridia,4BZ5Q@830|Butyrivibrio	186801|Clostridia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
CMS1_k127_1636377_0	1514668.JOOA01000001_gene583	4.727e-22	109.0	COG0448@1|root,COG0448@2|Bacteria,1TPZ3@1239|Firmicutes,2482Q@186801|Clostridia,3WGWM@541000|Ruminococcaceae	186801|Clostridia	G	Glucose-1-phosphate adenylyltransferase, GlgD subunit	glgD	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS1_k127_164780_0	1121007.AUML01000009_gene3822	1.337e-36	155.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,4NHCZ@976|Bacteroidetes,1HXNK@117743|Flavobacteriia,2YJ89@290174|Aquimarina	976|Bacteroidetes	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
CMS1_k127_1691064_1	1270196.JCKI01000002_gene426	3.203e-58	218.0	28JDN@1|root,2Z97Y@2|Bacteria,4NKYU@976|Bacteroidetes,1IW7G@117747|Sphingobacteriia	976|Bacteroidetes	H	DisA bacterial checkpoint controller nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N
CMS1_k127_1691064_2	1430440.MGMSRv2_2439	1.981e-27	119.0	COG1520@1|root,COG1520@2|Bacteria,1QV8R@1224|Proteobacteria	1224|Proteobacteria	G	6-phosphogluconolactonase activity	-	-	-	ko:K20952	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Beta-prism_lec,DUF4347,HYR,VCBS
CMS1_k127_1691064_0	1304284.L21TH_0550	1.891e-61	218.0	COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,24CPT@186801|Clostridia,36HYG@31979|Clostridiaceae	186801|Clostridia	S	channel protein, hemolysin III family	yqfA	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
CMS1_k127_1691064_3	1304885.AUEY01000013_gene3142	3.255e-24	117.0	COG2256@1|root,COG2256@2|Bacteria,1R1V5@1224|Proteobacteria,42TKJ@68525|delta/epsilon subdivisions,2WQEE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	atpase related to the helicase subunit of the holliday junction resolvase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
CMS1_k127_1698475_0	1041826.FCOL_06565	1.898e-48	198.0	2BWQ7@1|root,33XD9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1702295_0	272123.Anacy_0627	3.675e-45	180.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.15	ko:K01365,ko:K14475	ko04140,ko04142,ko04145,ko04210,ko04612,ko05143,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05143,map05205,map05323,map05418	-	-	-	ko00000,ko00001,ko00537,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I42,Peptidase_C1
CMS1_k127_1721322_0	545697.HMPREF0216_03090	8.961e-32	130.0	COG0671@1|root,COG0818@1|root,COG0671@2|Bacteria,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,248FD@186801|Clostridia,36DSP@31979|Clostridiaceae	186801|Clostridia	IM	Diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar,PAP2
CMS1_k127_1742616_0	929556.Solca_3821	6.675e-218	689.0	COG0564@1|root,COG0564@2|Bacteria,4NE9B@976|Bacteroidetes,1IQQK@117747|Sphingobacteriia	976|Bacteroidetes	J	Pseudouridine synthase	rluA	-	5.4.99.28,5.4.99.29	ko:K06177	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
CMS1_k127_1742616_1	1121875.KB907547_gene3317	3.562e-06	53.0	COG0457@1|root,COG0457@2|Bacteria,4NF5V@976|Bacteroidetes,1HYKU@117743|Flavobacteriia	976|Bacteroidetes	T	tetratricopeptide repeat	batE	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2
CMS1_k127_1756736_0	759914.BP951000_1335	8.789e-172	559.0	COG1256@1|root,COG1256@2|Bacteria,2J5TQ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,Flg_bbr_C
CMS1_k127_1756736_1	889378.Spiaf_0795	9.679e-77	272.0	COG1344@1|root,COG1344@2|Bacteria,2J6BJ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein 3	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
CMS1_k127_1756736_2	1123274.KB899419_gene1881	3.566e-33	134.0	COG1699@1|root,COG1699@2|Bacteria,2J7ZU@203691|Spirochaetes	203691|Spirochaetes	N	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
CMS1_k127_1756736_3	1289135.A966_09104	1.844e-18	87.0	COG1551@1|root,COG1551@2|Bacteria,2J8VE@203691|Spirochaetes	203691|Spirochaetes	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
CMS1_k127_1758554_2	459349.CLOAM0130	8.997e-47	180.0	COG0803@1|root,COG0803@2|Bacteria,2NPJM@2323|unclassified Bacteria	2|Bacteria	P	Zinc-uptake complex component A periplasmic	znuA	-	1.6.5.3	ko:K00341,ko:K02077,ko:K09815	ko00190,ko01100,ko02010,map00190,map01100,map02010	M00144,M00242,M00244	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5,3.D.1	-	-	ZnuA
CMS1_k127_1758554_0	459349.CLOAM0129	5.998e-72	250.0	COG1121@1|root,COG1121@2|Bacteria,2NPKC@2323|unclassified Bacteria	2|Bacteria	P	ATPases associated with a variety of cellular activities	znuC	-	-	ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
CMS1_k127_1758554_1	459349.CLOAM0128	2.203e-65	233.0	COG1108@1|root,COG1108@2|Bacteria,2NQ07@2323|unclassified Bacteria	2|Bacteria	P	ABC 3 transport family	znuB	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944	-	ko:K02075,ko:K09816,ko:K19976	ko02010,map02010	M00242,M00244,M00792	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.15,3.A.1.15.3,3.A.1.15.5	-	iJN678.slr2045	ABC-3
CMS1_k127_1772836_0	313606.M23134_05475	3.577e-101	349.0	COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,47MEM@768503|Cytophagia	976|Bacteroidetes	S	Alpha-2-macroglobulin family	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,CarbopepD_reg_2,Plug
CMS1_k127_1772836_2	926561.KB900620_gene3087	1.731e-73	255.0	COG1235@1|root,COG1235@2|Bacteria,1V2ET@1239|Firmicutes,24E1K@186801|Clostridia,3WA8A@53433|Halanaerobiales	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
CMS1_k127_1772836_1	498761.HM1_1450	5.518e-84	284.0	COG0685@1|root,COG0685@2|Bacteria,1U61W@1239|Firmicutes	1239|Firmicutes	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
CMS1_k127_1772836_3	717231.Flexsi_2211	2.768e-50	187.0	COG1434@1|root,COG1434@2|Bacteria,2GFV3@200930|Deferribacteres	200930|Deferribacteres	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
CMS1_k127_1772836_4	1458275.AZ34_12785	7.505e-49	187.0	2A8H0@1|root,30XJ2@2|Bacteria,1REE0@1224|Proteobacteria,2W21U@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1772836_5	744872.Spica_2526	3.357e-29	132.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2JBDH@203691|Spirochaetes	2|Bacteria	KT	7TM diverse intracellular signalling	rsbW	-	2.4.1.12,3.1.3.3	ko:K00694,ko:K07315,ko:K20977	ko00500,ko01100,ko02020,ko02025,ko02026,map00500,map01100,map02020,map02025,map02026	M00820	R02889	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000,ko02022,ko03021	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	HATPase_c_2,MatE,SpoIIE
CMS1_k127_1781039_0	1304284.L21TH_0012	9.847e-105	372.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,36F39@31979|Clostridiaceae	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS1_k127_178881_1	1218103.CIN01S_18_00450	4.063e-19	91.0	COG1335@1|root,COG1335@2|Bacteria,4NMQE@976|Bacteroidetes,1I2GJ@117743|Flavobacteriia,3ZR6G@59732|Chryseobacterium	976|Bacteroidetes	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
CMS1_k127_178881_0	1449050.JNLE01000003_gene2017	3.259e-69	245.0	COG2207@1|root,COG2207@2|Bacteria,1VANW@1239|Firmicutes,24J4D@186801|Clostridia,36GXQ@31979|Clostridiaceae	186801|Clostridia	K	PFAM Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS1_k127_178881_2	1403819.BATR01000031_gene992	2.923e-10	71.0	COG2208@1|root,COG2208@2|Bacteria,46SWK@74201|Verrucomicrobia,2ITX4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,SpoIIE
CMS1_k127_179242_0	1122605.KB893643_gene902	1.181e-87	295.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	2.1.1.331,2.1.1.332	ko:K13601,ko:K13602	ko00860,ko01110,map00860,map01110	-	R11507,R11508,R11509	RC03457,RC03458,RC03459	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS1_k127_179242_1	522306.CAP2UW1_4251	4.425e-34	134.0	2EBIG@1|root,335IZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1798220_0	1523503.JPMY01000023_gene1035	3.48e-44	174.0	COG2267@1|root,COG2267@2|Bacteria,1REM6@1224|Proteobacteria,1S4U1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
CMS1_k127_1799132_0	1313421.JHBV01000041_gene3629	2.413e-204	655.0	COG2304@1|root,COG2304@2|Bacteria,4NK2W@976|Bacteroidetes	976|Bacteroidetes	M	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	OmpA,VIT,VWA,VWA_3
CMS1_k127_1805946_1	665571.STHERM_c13210	1.414e-153	500.0	COG3604@1|root,COG3604@2|Bacteria,2J5TK@203691|Spirochaetes	203691|Spirochaetes	KT	Fis Family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
CMS1_k127_1805946_3	644281.MFS40622_0469	4.328e-48	176.0	COG0454@1|root,arCOG00826@2157|Archaea,2Y240@28890|Euryarchaeota,23RMS@183939|Methanococci	183939|Methanococci	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_1805946_0	331678.Cphamn1_1756	3.094e-224	701.0	COG2710@1|root,COG2710@2|Bacteria,1FDCK@1090|Chlorobi	1090|Chlorobi	H	Belongs to the NifD NifK NifE NifN family	-	-	-	ko:K02587	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
CMS1_k127_1805946_2	517418.Ctha_1029	4.247e-84	284.0	COG2710@1|root,COG2710@2|Bacteria,1FDC9@1090|Chlorobi	1090|Chlorobi	C	Belongs to the NifD NifK NifE NifN family	-	-	-	ko:K02592	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
CMS1_k127_1824158_4	1121422.AUMW01000007_gene3190	1.078e-98	334.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,260P5@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
CMS1_k127_1824158_0	706587.Desti_3053	1.735e-300	946.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
CMS1_k127_1824158_3	1379698.RBG1_1C00001G0687	1.708e-116	389.0	COG1109@1|root,COG1109@2|Bacteria,2NNM3@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	glmM	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K01840,ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS1_k127_1824158_6	1307761.L21SP2_1148	5.866e-32	135.0	2E1YA@1|root,32X70@2|Bacteria,2J5Q9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1824158_5	1232410.KI421424_gene1720	2.954e-71	253.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,42MTI@68525|delta/epsilon subdivisions,2WIXW@28221|Deltaproteobacteria,43S42@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	HrcA protein C terminal domain	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
CMS1_k127_1824158_7	3702.AT4G26780.1	2.379e-18	94.0	COG0576@1|root,KOG3003@2759|Eukaryota,37K53@33090|Viridiplantae,3GCBQ@35493|Streptophyta,3HMZM@3699|Brassicales	35493|Streptophyta	O	Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner	-	GO:0000166,GO:0000774,GO:0001405,GO:0003674,GO:0005488,GO:0005507,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005744,GO:0006605,GO:0006626,GO:0006810,GO:0006839,GO:0006886,GO:0006950,GO:0006996,GO:0007005,GO:0008104,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009408,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0010286,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0017038,GO:0017076,GO:0019866,GO:0030150,GO:0030234,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044743,GO:0045184,GO:0046872,GO:0046907,GO:0046914,GO:0050790,GO:0050896,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0060589,GO:0060590,GO:0065002,GO:0065007,GO:0065009,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072655,GO:0097159,GO:0097367,GO:0098772,GO:0098796,GO:0098798,GO:0098800,GO:1901265,GO:1901363,GO:1990542	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
CMS1_k127_1824158_1	1123274.KB899431_gene3268	1.059e-285	890.0	COG0443@1|root,COG0443@2|Bacteria,2J5I0@203691|Spirochaetes	203691|Spirochaetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
CMS1_k127_1824158_2	1121918.ARWE01000001_gene3463	1.981e-124	409.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,43SEG@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	DnaJ central domain	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS1_k127_1826230_0	754027.HMPREF9554_03138	6.148e-135	452.0	COG2114@1|root,COG3850@1|root,COG2114@2|Bacteria,COG3850@2|Bacteria,2J5GP@203691|Spirochaetes	203691|Spirochaetes	T	guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
CMS1_k127_1826230_1	1410609.JHVB01000003_gene315	9.587e-20	101.0	COG4254@1|root,COG4254@2|Bacteria,2J772@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS1_k127_1837625_12	1131462.DCF50_p372	1.486e-05	51.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,24M2Q@186801|Clostridia,261QR@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
CMS1_k127_1837625_1	1111134.HMPREF1253_1549	5.028e-106	358.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
CMS1_k127_1837625_7	945713.IALB_1327	4.83e-27	119.0	COG0558@1|root,COG0558@2|Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iIT341.HP1016,iJN678.pgsA,iSB619.SA_RS06365	CDP-OH_P_transf
CMS1_k127_1837625_6	96561.Dole_1265	1.837e-27	118.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,42U6G@68525|delta/epsilon subdivisions,2WQDR@28221|Deltaproteobacteria,2MKIR@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0195	PgpA
CMS1_k127_1837625_5	573413.Spirs_1942	8.724e-39	150.0	COG0537@1|root,COG0537@2|Bacteria,2JAFV@203691|Spirochaetes	203691|Spirochaetes	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT
CMS1_k127_1837625_8	1121413.JMKT01000008_gene1463	3.521e-14	77.0	COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2MBWU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS1_k127_1837625_11	656519.Halsa_1975	3.61e-06	53.0	COG3679@1|root,COG3679@2|Bacteria	2|Bacteria	S	Belongs to the UPF0342 family	-	-	-	-	-	-	-	-	-	-	-	-	Com_YlbF
CMS1_k127_1837625_0	56780.SYN_00908	6.723e-139	452.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,2MQ6A@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_1837625_3	869209.Tresu_1240	3.844e-70	249.0	COG1235@1|root,COG1235@2|Bacteria,2J5C5@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS1_k127_1837625_4	338963.Pcar_0085	2.137e-52	192.0	COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,42PJH@68525|delta/epsilon subdivisions,2WMZT@28221|Deltaproteobacteria,43SGD@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS1_k127_1837625_2	469615.FGAG_00073	5.856e-97	332.0	COG0168@1|root,COG0168@2|Bacteria,37893@32066|Fusobacteria	32066|Fusobacteria	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS1_k127_1837625_9	649638.Trad_2755	1.017e-07	57.0	COG0776@1|root,COG0776@2|Bacteria,1WK4X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS1_k127_1837625_10	1121413.JMKT01000009_gene1972	3.329e-07	55.0	COG0268@1|root,COG0268@2|Bacteria,1NITA@1224|Proteobacteria,42V4U@68525|delta/epsilon subdivisions,2WR9I@28221|Deltaproteobacteria,2MD9B@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
CMS1_k127_1845853_2	1499689.CCNN01000007_gene2612	2.069e-16	90.0	COG3594@1|root,COG3594@2|Bacteria,1VECK@1239|Firmicutes,25EWI@186801|Clostridia,36PSS@31979|Clostridiaceae	186801|Clostridia	G	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
CMS1_k127_1845853_1	457396.CSBG_02716	2.508e-21	95.0	COG0454@1|root,COG0456@2|Bacteria,1V562@1239|Firmicutes,24G6G@186801|Clostridia,36HZD@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_1845853_0	573413.Spirs_0653	6.706e-59	210.0	COG1280@1|root,COG1280@2|Bacteria	2|Bacteria	E	homoserine transmembrane transporter activity	MA20_04860	-	-	-	-	-	-	-	-	-	-	-	LysE
CMS1_k127_1858308_0	1286171.EAL2_c13960	8.837e-69	241.0	COG1853@1|root,COG1853@2|Bacteria,1UYJS@1239|Firmicutes,24CVK@186801|Clostridia,25WTY@186806|Eubacteriaceae	186801|Clostridia	S	Flavin reductase like domain	flr	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
CMS1_k127_1858308_1	1123373.ATXI01000008_gene1620	2.739e-09	59.0	COG1328@1|root,COG1328@2|Bacteria,2GI4Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Anaerobic ribonucleoside-triphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	NRDD
CMS1_k127_1858388_0	1291050.JAGE01000002_gene3558	1.75e-206	658.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes	1239|Firmicutes	Q	synthase	-	-	-	ko:K13612,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS1_k127_1864718_8	118005.AWNK01000016_gene1001	4.998e-16	82.0	COG1321@1|root,COG1321@2|Bacteria	2|Bacteria	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
CMS1_k127_1864718_11	1304284.L21TH_1712	6.915e-09	62.0	2B25P@1|root,31UNY@2|Bacteria,1URPP@1239|Firmicutes,24UZ1@186801|Clostridia,36P1Y@31979|Clostridiaceae	186801|Clostridia	S	Family of unknown function (DUF5320)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5320
CMS1_k127_1864718_4	933262.AXAM01000049_gene3253	1.625e-80	276.0	COG1149@1|root,COG1149@2|Bacteria,1NCD9@1224|Proteobacteria,42PHV@68525|delta/epsilon subdivisions,2WKDZ@28221|Deltaproteobacteria,2MIUE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
CMS1_k127_1864718_1	485916.Dtox_1233	5.237e-91	308.0	COG1149@1|root,COG1149@2|Bacteria,1TQI9@1239|Firmicutes,2484J@186801|Clostridia,261J0@186807|Peptococcaceae	186801|Clostridia	C	Cobyrinic acid ac-diamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
CMS1_k127_1864718_2	243231.GSU1408	2.006e-89	303.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,43TAG@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	Nitro_FeMo-Co,ParA
CMS1_k127_1864718_6	1121451.DESAM_20286	1.8e-37	143.0	COG0489@1|root,COG1433@1|root,COG0489@2|Bacteria,COG1433@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2M7XI@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	Nitro_FeMo-Co,ParA
CMS1_k127_1864718_9	443143.GM18_1387	1.122e-15	87.0	COG0823@1|root,COG1470@1|root,COG4625@1|root,COG0823@2|Bacteria,COG1470@2|Bacteria,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	-	ko:K13669	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	DUF11,GT87,He_PIG,HemolysinCabind,PD40
CMS1_k127_1864718_3	509191.AEDB02000059_gene403	7.599e-81	274.0	COG0637@1|root,COG0637@2|Bacteria,1VA5Z@1239|Firmicutes,24JNY@186801|Clostridia,3WI50@541000|Ruminococcaceae	186801|Clostridia	S	IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS1_k127_1864718_0	390874.Tpet_0889	2.268e-102	344.0	COG2768@1|root,COG2768@2|Bacteria,2GC95@200918|Thermotogae	200918|Thermotogae	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
CMS1_k127_1864718_7	862908.BMS_2153	2.137e-23	111.0	COG2911@1|root,COG3210@1|root,COG3420@1|root,COG5295@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,COG5295@2|Bacteria,1NGFP@1224|Proteobacteria,43EIP@68525|delta/epsilon subdivisions,2MUTH@213481|Bdellovibrionales,2X8HE@28221|Deltaproteobacteria	213481|Bdellovibrionales	U	Chaperone of endosialidase	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Peptidase_S74
CMS1_k127_1864718_5	491952.Mar181_2601	1.674e-42	165.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1XH6N@135619|Oceanospirillales	135619|Oceanospirillales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
CMS1_k127_1864718_10	290315.Clim_0617	1.086e-11	74.0	COG0457@1|root,COG0457@2|Bacteria,1FDVB@1090|Chlorobi	1090|Chlorobi	S	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
CMS1_k127_1864718_12	1304885.AUEY01000021_gene3448	6.473e-08	55.0	COG1309@1|root,COG1309@2|Bacteria,1MYFS@1224|Proteobacteria,42T8F@68525|delta/epsilon subdivisions,2WPCH@28221|Deltaproteobacteria,2MK58@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_1867420_1	269799.Gmet_2708	2.511e-45	171.0	COG0835@1|root,COG0835@2|Bacteria,1RJKY@1224|Proteobacteria,42SN3@68525|delta/epsilon subdivisions,2WPCG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS1_k127_1867420_0	296591.Bpro_2459	9.076e-114	385.0	COG0457@1|root,COG1352@1|root,COG0457@2|Bacteria,COG1352@2|Bacteria,1MVP3@1224|Proteobacteria,2W8ZD@28216|Betaproteobacteria,4AFA1@80864|Comamonadaceae	28216|Betaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR
CMS1_k127_1867420_2	1288494.EBAPG3_20750	7.28e-22	101.0	COG0835@1|root,COG0835@2|Bacteria,1N1YU@1224|Proteobacteria,2VV4H@28216|Betaproteobacteria,374N5@32003|Nitrosomonadales	28216|Betaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS1_k127_1868594_6	247490.KSU1_A0086	4.771e-84	302.0	COG0642@1|root,COG2205@2|Bacteria,2J4XW@203682|Planctomycetes	203682|Planctomycetes	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS1_k127_1868594_28	237368.SCABRO_00636	2.153e-34	135.0	COG0745@1|root,COG0745@2|Bacteria,2J3JT@203682|Planctomycetes	203682|Planctomycetes	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS1_k127_1868594_25	795359.TOPB45_1346	1.049e-36	142.0	COG0720@1|root,COG0720@2|Bacteria,2GHTY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
CMS1_k127_1868594_19	237368.SCABRO_02864	1.223e-48	187.0	COG0399@1|root,COG0399@2|Bacteria,2IYUJ@203682|Planctomycetes	203682|Planctomycetes	E	pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
CMS1_k127_1868594_23	933262.AXAM01000002_gene559	1.796e-37	153.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2WMCA@28221|Deltaproteobacteria,2MHV7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
CMS1_k127_1868594_36	1284708.HMPREF1634_06050	2.312e-15	76.0	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes,24QK0@186801|Clostridia,3WCPX@538999|Clostridiales incertae sedis	186801|Clostridia	J	50S ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
CMS1_k127_1868594_38	1174504.AJTN02000017_gene212	2.405e-07	54.0	COG0690@1|root,COG0690@2|Bacteria,1VK48@1239|Firmicutes,4HR1W@91061|Bacilli,1ZIY2@1386|Bacillus	91061|Bacilli	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
CMS1_k127_1868594_18	1121423.JONT01000033_gene2660	5.13e-52	189.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,260QW@186807|Peptococcaceae	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
CMS1_k127_1868594_13	1122238.AULR01000010_gene259	1.654e-57	203.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4FNGC@85023|Microbacteriaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
CMS1_k127_1868594_8	522772.Dacet_0362	1.854e-72	252.0	COG0081@1|root,COG0081@2|Bacteria,2GF5D@200930|Deferribacteres	200930|Deferribacteres	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
CMS1_k127_1868594_29	926561.KB900620_gene3210	1.966e-31	129.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,3WANA@53433|Halanaerobiales	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
CMS1_k127_1868594_26	583355.Caka_2709	3.531e-36	141.0	COG0222@1|root,COG0222@2|Bacteria,46SWC@74201|Verrucomicrobia,3K84B@414999|Opitutae	414999|Opitutae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
CMS1_k127_1868594_1	744872.Spica_0379	0.0	1349.0	COG0085@1|root,COG0085@2|Bacteria,2J5JV@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
CMS1_k127_1868594_0	1480694.DC28_14380	0.0	1675.0	COG0086@1|root,COG0086@2|Bacteria,2J5S7@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
CMS1_k127_1868594_9	1307761.L21SP2_2701	4.6e-67	229.0	COG0048@1|root,COG0048@2|Bacteria,2J7NE@203691|Spirochaetes	203691|Spirochaetes	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
CMS1_k127_1868594_11	1121948.AUAC01000001_gene2947	8.302e-65	224.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,43XE5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
CMS1_k127_1868594_2	316067.Geob_3628	7.399e-263	826.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS1_k127_1868594_3	504728.K649_09430	3.973e-198	624.0	COG0050@1|root,COG0050@2|Bacteria,1WI4Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
CMS1_k127_1868594_22	1297742.A176_01558	2.895e-39	148.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria,2YV49@29|Myxococcales	28221|Deltaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
CMS1_k127_1868594_12	857293.CAAU_1227	3.759e-62	220.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,36DP8@31979|Clostridiaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
CMS1_k127_1868594_16	279808.SH0803	7.812e-53	193.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4HB01@91061|Bacilli,4GXNT@90964|Staphylococcaceae	91061|Bacilli	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
CMS1_k127_1868594_34	479434.Sthe_1038	1.23e-20	94.0	COG0089@1|root,COG0089@2|Bacteria,2G73T@200795|Chloroflexi,27YJ6@189775|Thermomicrobia	189775|Thermomicrobia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
CMS1_k127_1868594_4	880073.Calab_2129	9.003e-113	369.0	COG0090@1|root,COG0090@2|Bacteria,2NNR3@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
CMS1_k127_1868594_27	398512.JQKC01000042_gene4190	1.064e-35	137.0	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,3WJ9F@541000|Ruminococcaceae	186801|Clostridia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
CMS1_k127_1868594_30	1121085.AUCI01000022_gene31	2.475e-29	120.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,4HIK2@91061|Bacilli,1ZG6U@1386|Bacillus	91061|Bacilli	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
CMS1_k127_1868594_7	551789.ATVJ01000002_gene3217	5.778e-77	263.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2TRZ2@28211|Alphaproteobacteria,43X7M@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
CMS1_k127_1868594_17	439235.Dalk_1908	2.132e-52	188.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2WP71@28221|Deltaproteobacteria,2MJKH@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
CMS1_k127_1868594_39	997346.HMPREF9374_2854	3.106e-05	49.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,4HNUP@91061|Bacilli,27CDH@186824|Thermoactinomycetaceae	91061|Bacilli	J	Ribosomal L29 protein	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
CMS1_k127_1868594_32	476272.RUMHYD_02787	2.549e-27	113.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,3Y0D6@572511|Blautia	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
CMS1_k127_1868594_20	56780.SYN_03257	1.527e-46	170.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,42RHR@68525|delta/epsilon subdivisions,2WNEK@28221|Deltaproteobacteria,2MRPG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
CMS1_k127_1868594_35	999415.HMPREF9943_00563	2.298e-20	94.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,3VRDS@526524|Erysipelotrichia	526524|Erysipelotrichia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
CMS1_k127_1868594_10	1235796.C815_02165	1.058e-66	231.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes	1239|Firmicutes	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
CMS1_k127_1868594_33	158189.SpiBuddy_2837	1.891e-24	103.0	COG0199@1|root,COG0199@2|Bacteria,2J8U1@203691|Spirochaetes	203691|Spirochaetes	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
CMS1_k127_1868594_21	933262.AXAM01000052_gene2003	1.06e-43	163.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2WPDP@28221|Deltaproteobacteria,2MJZV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
CMS1_k127_1868594_14	582402.Hbal_2068	1.081e-56	203.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria,43XQJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
CMS1_k127_1868594_31	1382315.JPOI01000001_gene736	1.638e-27	115.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,4HIGF@91061|Bacilli,1WGHA@129337|Geobacillus	91061|Bacilli	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
CMS1_k127_1868594_15	373903.Hore_01340	6.564e-56	200.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,3WAKQ@53433|Halanaerobiales	186801|Clostridia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
CMS1_k127_1868594_37	350688.Clos_0510	9.588e-14	72.0	COG1841@1|root,COG1841@2|Bacteria	2|Bacteria	J	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
CMS1_k127_1868594_24	1131269.AQVV01000040_gene1632	4.07e-37	145.0	COG0200@1|root,COG0200@2|Bacteria	2|Bacteria	J	rRNA binding	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
CMS1_k127_1868594_5	1340493.JNIF01000003_gene3227	1.521e-104	353.0	COG0201@1|root,COG0201@2|Bacteria,3Y38D@57723|Acidobacteria	57723|Acidobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
CMS1_k127_1876392_0	1123326.JFBL01000011_gene175	2.088e-250	790.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2YMB2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS1_k127_1876392_7	944479.JQLX01000014_gene1649	2.905e-32	130.0	COG1321@1|root,COG1321@2|Bacteria,1RHIK@1224|Proteobacteria,42SAD@68525|delta/epsilon subdivisions,2X6HJ@28221|Deltaproteobacteria,2M76C@213113|Desulfurellales	28221|Deltaproteobacteria	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
CMS1_k127_1876392_6	997350.HMPREF9129_1071	6.63e-46	173.0	COG1351@1|root,COG1351@2|Bacteria,1TRAA@1239|Firmicutes,249DJ@186801|Clostridia,22GCB@1570339|Peptoniphilaceae	186801|Clostridia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
CMS1_k127_1876392_3	572544.Ilyop_0022	2.178e-68	237.0	COG4657@1|root,COG4657@2|Bacteria,3783Q@32066|Fusobacteria	32066|Fusobacteria	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS1_k127_1876392_4	177437.HRM2_32100	2.104e-56	203.0	COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,42NVB@68525|delta/epsilon subdivisions,2WK6R@28221|Deltaproteobacteria,2MINN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
CMS1_k127_1876392_9	386415.NT01CX_1581	2.012e-16	87.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia,36K2X@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
CMS1_k127_1876392_2	536232.CLM_0437	4.94e-83	289.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,36FI0@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
CMS1_k127_1876392_1	332101.JIBU02000023_gene5064	8.325e-124	410.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,36F8C@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB
CMS1_k127_1876392_8	1289135.A966_09269	1.641e-25	108.0	2C3HB@1|root,333QE@2|Bacteria,2J8P5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1876392_5	555088.DealDRAFT_2287	2.162e-50	190.0	COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,24ADG@186801|Clostridia	186801|Clostridia	M	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
CMS1_k127_1924572_1	632245.CLP_1735	1.307e-138	464.0	COG0366@1|root,COG0366@2|Bacteria,1TQSE@1239|Firmicutes,24C4V@186801|Clostridia,36H6T@31979|Clostridiaceae	186801|Clostridia	G	alpha-amylase	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26,CBM53,Y_Y_Y
CMS1_k127_1924572_4	1129374.AJE_10774	2.37e-31	142.0	COG0366@1|root,COG0366@2|Bacteria,1MX9V@1224|Proteobacteria,1RP7Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cytoplasmic alpha-amylase	amyA	GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016160,GO:0016787,GO:0016798,GO:0044424,GO:0044464	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	iECH74115_1262.ECH74115_2702,iECSP_1301.ECSP_2532,iECs_1301.ECs2666,iG2583_1286.G2583_2378,iSF_1195.SF1970	Alpha-amylase,Alpha-amylase_C,DUF1939
CMS1_k127_1924572_7	573569.F7308_0712	2.583e-05	53.0	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,1SA94@1236|Gammaproteobacteria,461HG@72273|Thiotrichales	72273|Thiotrichales	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS1_k127_1924572_0	931626.Awo_c16770	3.594e-168	536.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia,25WNE@186806|Eubacteriaceae	186801|Clostridia	C	Malate/L-lactate dehydrogenase	mdh	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
CMS1_k127_1924572_2	760154.Sulba_1200	1.406e-52	192.0	COG2095@1|root,COG2095@2|Bacteria,1REGK@1224|Proteobacteria,42RH8@68525|delta/epsilon subdivisions,2YPEJ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	membrane	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
CMS1_k127_1924572_3	96561.Dole_0951	2.078e-36	156.0	COG4977@1|root,COG4977@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
CMS1_k127_1924572_6	243090.RB9666	2.027e-10	68.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS1_k127_1931426_0	1144275.COCOR_07806	6.097e-80	274.0	COG4249@1|root,COG4249@2|Bacteria,1QX7K@1224|Proteobacteria,43AHW@68525|delta/epsilon subdivisions,2X5Y0@28221|Deltaproteobacteria,2YZCA@29|Myxococcales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
CMS1_k127_1931426_1	877418.ATWV01000013_gene2429	6.553e-18	93.0	COG5662@1|root,COG5662@2|Bacteria,2J8QA@203691|Spirochaetes	203691|Spirochaetes	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_1931426_2	59374.Fisuc_0912	2.439e-09	60.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ECF,Sigma70_r2,Sigma70_r4_2
CMS1_k127_1962941_3	573413.Spirs_4183	1.547e-38	146.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yiaC	-	2.3.1.1	ko:K03826,ko:K22476	ko00220,ko01210,ko01230,map00220,map01210,map01230	-	R00259	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_10,Acetyltransf_7
CMS1_k127_1962941_1	1042163.BRLA_c023010	2.803e-64	221.0	COG4319@1|root,COG4319@2|Bacteria,1V5V3@1239|Firmicutes,4HIZV@91061|Bacilli	91061|Bacilli	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
CMS1_k127_1962941_2	1301100.HG529321_gene6079	4.599e-49	182.0	COG4845@1|root,COG4845@2|Bacteria,1UY81@1239|Firmicutes,24853@186801|Clostridia,36FEU@31979|Clostridiaceae	186801|Clostridia	V	This enzyme is an effector of chloramphenicol resistance in bacteria	cat	-	2.3.1.28	ko:K19271	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	CAT
CMS1_k127_1962941_0	889378.Spiaf_2266	5.931e-90	298.0	COG3506@1|root,COG3506@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1349)	-	-	-	ko:K09702	-	-	-	-	ko00000	-	-	-	DUF1349
CMS1_k127_1986717_1	985255.APHJ01000018_gene3051	1.374e-160	509.0	COG0145@1|root,COG0145@2|Bacteria,4NFBV@976|Bacteroidetes	976|Bacteroidetes	EQ	Hydantoinase/oxoprolinase	-	-	3.5.2.14,3.5.2.9	ko:K01469,ko:K01473	ko00330,ko00480,ko01100,map00330,map00480,map01100	-	R00251,R03187	RC00553,RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
CMS1_k127_1986717_0	985255.APHJ01000018_gene3052	0.0	1030.0	COG0146@1|root,COG0146@2|Bacteria,4PM5E@976|Bacteroidetes	976|Bacteroidetes	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
CMS1_k127_198689_3	745277.GRAQ_03545	3.838e-07	63.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,3FF1P@34037|Rahnella	1236|Gammaproteobacteria	MU	type I secretion outer membrane protein, TolC family	tolC	GO:0002790,GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0010033,GO:0014070,GO:0015031,GO:0015075,GO:0015267,GO:0015288,GO:0015318,GO:0015562,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022838,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042930,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046618,GO:0046903,GO:0047485,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901678,GO:1902495,GO:1990195,GO:1990196,GO:1990281,GO:1990351	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	iAPECO1_1312.APECO1_3378,iEC042_1314.EC042_3326,iECOK1_1307.ECOK1_3463	OEP
CMS1_k127_198689_2	1121129.KB903359_gene2286	1.141e-43	174.0	COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes,2FN2G@200643|Bacteroidia,22W7Z@171551|Porphyromonadaceae	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
CMS1_k127_198689_1	385682.AFSL01000105_gene124	1.704e-79	273.0	COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,2FPB3@200643|Bacteroidia,3XJEI@558415|Marinilabiliaceae	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_198689_0	497964.CfE428DRAFT_5023	1.488e-82	288.0	COG0577@1|root,COG0577@2|Bacteria,46U7K@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
CMS1_k127_1988878_2	744872.Spica_0016	6.235e-45	174.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS1_k127_1988878_0	1304888.ATWF01000001_gene1486	1.129e-146	469.0	COG0752@1|root,COG0752@2|Bacteria,2GEZ4@200930|Deferribacteres	200930|Deferribacteres	J	Glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
CMS1_k127_1988878_1	573413.Spirs_2422	1.488e-63	229.0	COG0618@1|root,COG0618@2|Bacteria,2J74X@203691|Spirochaetes	203691|Spirochaetes	S	DHHA1 domain	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS1_k127_2014683_0	192952.MM_2204	0.0	1475.0	COG0610@1|root,arCOG00878@2157|Archaea,2XSZ2@28890|Euryarchaeota,2N95V@224756|Methanomicrobia	224756|Methanomicrobia	V	Domain of unknown function (DUF3387)	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
CMS1_k127_2014683_4	1202532.FF52_06300	3.419e-07	61.0	COG1196@1|root,COG1196@2|Bacteria,4NV1E@976|Bacteroidetes,1I6Q0@117743|Flavobacteriia	976|Bacteroidetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2014683_1	1234664.AMRO01000078_gene2516	1.099e-107	359.0	COG4127@1|root,COG4127@2|Bacteria,1UZ8T@1239|Firmicutes,4HE0Y@91061|Bacilli,1WHVN@129337|Geobacillus	91061|Bacilli	L	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat
CMS1_k127_2014683_5	999413.HMPREF1094_00622	2.295e-06	54.0	COG1476@1|root,COG1476@2|Bacteria,1V2KY@1239|Firmicutes,3VQ98@526524|Erysipelotrichia	526524|Erysipelotrichia	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_2014683_2	517418.Ctha_1121	3.967e-84	286.0	COG2602@1|root,COG2602@2|Bacteria,1FE67@1090|Chlorobi	1090|Chlorobi	M	PFAM penicillin-binding protein transpeptidase	-	-	3.5.2.6	ko:K17838	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Transpeptidase
CMS1_k127_2030051_0	868131.MSWAN_0569	8.693e-83	288.0	COG0119@1|root,arCOG02092@2157|Archaea,2XV8D@28890|Euryarchaeota,23PFQ@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	aksA	-	2.3.3.14	ko:K10977	ko00300,ko00620,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00620,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R00271,R08213,R08331,R08332	RC00004,RC00067,RC02149,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
CMS1_k127_2030051_1	1410609.JHVB01000007_gene980	1.591e-09	70.0	2EW9A@1|root,33PN0@2|Bacteria,2J6QJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS1_k127_2048381_1	363253.LI0433	1.332e-10	65.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2WKBG@28221|Deltaproteobacteria,2M7VH@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	PFAM cytochrome c biogenesis protein transmembrane region	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
CMS1_k127_2048381_0	926692.AZYG01000047_gene2654	2.174e-132	434.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,3WB0C@53433|Halanaerobiales	186801|Clostridia	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
CMS1_k127_2052554_0	1191523.MROS_1860	3.812e-33	145.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	GAF,GAF_2,HATPase_c_2,SSF,SpoIIE
CMS1_k127_2055728_0	436114.SYO3AOP1_0232	1.988e-60	223.0	COG2265@1|root,COG2265@2|Bacteria,2G3V7@200783|Aquificae	200783|Aquificae	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
CMS1_k127_2056889_1	748449.Halha_1022	0.0006219	52.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
CMS1_k127_205823_1	378806.STAUR_6512	2.228e-81	295.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,43AH9@68525|delta/epsilon subdivisions,2X5XB@28221|Deltaproteobacteria,2Z37F@29|Myxococcales	28221|Deltaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS1_k127_205823_0	1120970.AUBZ01000003_gene113	2.493e-168	563.0	COG0366@1|root,COG5492@1|root,COG0366@2|Bacteria,COG5492@2|Bacteria,1NUIZ@1224|Proteobacteria,1RPMQ@1236|Gammaproteobacteria,465DG@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Alpha amylase, catalytic domain	cgt	-	2.4.1.19	ko:K00701	ko00500,map00500	-	R11260	-	ko00000,ko00001,ko01000	-	CBM20,GH13	-	Alpha-amylase
CMS1_k127_205823_2	1121451.DESAM_20646	1.15e-56	202.0	COG1528@1|root,COG1528@2|Bacteria,1R9ZC@1224|Proteobacteria,42S74@68525|delta/epsilon subdivisions,2WNFJ@28221|Deltaproteobacteria,2MBEX@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Iron-storage protein	ftn	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
CMS1_k127_2097464_0	63737.Npun_R4176	5.035e-49	182.0	COG0288@1|root,COG0288@2|Bacteria,1G88N@1117|Cyanobacteria,1HTW8@1161|Nostocales	1117|Cyanobacteria	H	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
CMS1_k127_2097464_1	1278073.MYSTI_06681	2.012e-48	183.0	COG3568@1|root,COG3568@2|Bacteria,1N3A7@1224|Proteobacteria	1224|Proteobacteria	L	Endonuclease Exonuclease Phosphatase	-	-	3.1.3.90	ko:K06896	ko00500,map00500	-	R10486	RC00017	ko00000,ko00001,ko01000	-	-	-	CBM_21,Exo_endo_phos
CMS1_k127_2104885_0	1123274.KB899407_gene384	3.823e-102	351.0	COG0515@1|root,COG0515@2|Bacteria,2J6N6@203691|Spirochaetes	203691|Spirochaetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
CMS1_k127_2104885_1	1123274.KB899407_gene385	1.004e-68	244.0	COG0639@1|root,COG0639@2|Bacteria,2J6GE@203691|Spirochaetes	203691|Spirochaetes	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS1_k127_2113563_1	28072.Nos7524_1268	1.691e-08	59.0	COG3501@1|root,COG3501@2|Bacteria,1G6H3@1117|Cyanobacteria,1HMJM@1161|Nostocales	1117|Cyanobacteria	S	PFAM Phage-related baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2113563_0	373994.Riv7116_1697	1.763e-25	118.0	COG3500@1|root,COG3500@2|Bacteria,1G4DS@1117|Cyanobacteria,1HMCU@1161|Nostocales	1117|Cyanobacteria	S	PFAM Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
CMS1_k127_2116261_2	313606.M23134_02861	2.637e-10	63.0	COG2885@1|root,COG2885@2|Bacteria,4P5MU@976|Bacteroidetes	976|Bacteroidetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
CMS1_k127_2116261_1	1237149.C900_02065	3.32e-16	86.0	2EJ5R@1|root,33CWY@2|Bacteria,4NYJK@976|Bacteroidetes,47SY4@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2116261_0	1408473.JHXO01000009_gene3452	9.913e-63	219.0	COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
CMS1_k127_2117024_0	869209.Tresu_1176	8.598e-35	142.0	COG0500@1|root,COG1861@1|root,COG0500@2|Bacteria,COG1861@2|Bacteria,2J58C@203691|Spirochaetes	203691|Spirochaetes	M	spore coat polysaccharide biosynthesis protein	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3,Methyltransf_23
CMS1_k127_2117024_2	553973.CLOHYLEM_05264	1.714e-19	94.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,21YUQ@1506553|Lachnoclostridium	186801|Clostridia	JKL	DEAD DEAH box helicase	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
CMS1_k127_2117024_1	243164.DET1126	1.213e-31	128.0	COG0745@1|root,COG0745@2|Bacteria,2GARH@200795|Chloroflexi,34D69@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Trans_reg_C
CMS1_k127_2128852_1	929506.CbC4_2531	7.958e-88	294.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,36DP4@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
CMS1_k127_2128852_2	1449063.JMLS01000025_gene4029	1.515e-63	229.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBED@91061|Bacilli,26RTC@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_2128852_3	387631.Asulf_00927	9.264e-42	166.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,246S3@183980|Archaeoglobi	183980|Archaeoglobi	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
CMS1_k127_2128852_0	880072.Desac_2027	3.791e-125	413.0	COG3635@1|root,COG3635@2|Bacteria,1R4TM@1224|Proteobacteria,42NCT@68525|delta/epsilon subdivisions,2WKEG@28221|Deltaproteobacteria,2MQ6B@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Proposed homoserine kinase	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
CMS1_k127_2128852_4	665571.STHERM_c07880	3.901e-15	83.0	2EY48@1|root,33RD4@2|Bacteria,2J65N@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
CMS1_k127_2129779_0	903818.KI912269_gene310	3.719e-166	541.0	COG1032@1|root,COG1032@2|Bacteria,3Y2NI@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
CMS1_k127_2139777_4	1034769.KB910518_gene3545	4.727e-36	145.0	COG1305@1|root,COG1305@2|Bacteria,1VH75@1239|Firmicutes,4HT6Z@91061|Bacilli,271KE@186822|Paenibacillaceae	91061|Bacilli	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS1_k127_2139777_0	865861.AZSU01000003_gene1746	2.527e-153	493.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
CMS1_k127_2139777_3	1278073.MYSTI_04616	5.51e-69	242.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2YU2D@29|Myxococcales	28221|Deltaproteobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
CMS1_k127_2139777_2	316067.Geob_0701	1.268e-94	316.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,43TUX@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
CMS1_k127_2139777_1	273068.TTE1183	6.389e-138	448.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,42EMN@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
CMS1_k127_2145112_3	1195236.CTER_1194	1.314e-08	63.0	COG1653@1|root,COG1653@2|Bacteria,1TRAX@1239|Firmicutes,2497E@186801|Clostridia,3WH7S@541000|Ruminococcaceae	1239|Firmicutes	G	ABC-type sugar transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2145112_4	378806.STAUR_4503	3.232e-06	58.0	COG0457@1|root,COG0457@2|Bacteria	378806.STAUR_4503|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2145112_0	746697.Aeqsu_0256	1.937e-38	149.0	COG4783@1|root,COG4783@2|Bacteria,4NTS7@976|Bacteroidetes,1IKCF@117743|Flavobacteriia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
CMS1_k127_2145112_1	1123401.JHYQ01000037_gene1646	5.046e-31	128.0	2ERHA@1|root,33J2S@2|Bacteria,1NH9V@1224|Proteobacteria	1224|Proteobacteria	S	GDYXXLXY protein	-	-	-	-	-	-	-	-	-	-	-	-	GDYXXLXY
CMS1_k127_2145112_2	1123399.AQVE01000014_gene67	1.318e-14	77.0	COG4872@1|root,COG4872@2|Bacteria,1N4JN@1224|Proteobacteria	1224|Proteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
CMS1_k127_2154335_0	880072.Desac_1025	1.032e-91	323.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MR0U@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS1_k127_2154335_1	796940.HMPREF9628_01999	2.752e-85	302.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,25QHB@186804|Peptostreptococcaceae	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
CMS1_k127_2163593_1	1192034.CAP_7988	5.115e-49	198.0	COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,Cache_3-Cache_2,HAMP,HATPase_c_2,SpoIIE,dCache_1,dCache_2
CMS1_k127_2163593_0	1121904.ARBP01000002_gene7136	2.126e-49	183.0	COG0637@1|root,COG0637@2|Bacteria,4NEEH@976|Bacteroidetes,47RK3@768503|Cytophagia	976|Bacteroidetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS1_k127_2163593_2	1408473.JHXO01000008_gene2639	1.331e-44	177.0	COG1520@1|root,COG1520@2|Bacteria,4NFA9@976|Bacteroidetes,2FPAX@200643|Bacteroidia	976|Bacteroidetes	M	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,PQQ,PQQ_2,PQQ_3
CMS1_k127_2172513_4	403833.Pmob_0063	4.279e-42	158.0	COG2869@1|root,COG2869@2|Bacteria,2GCZN@200918|Thermotogae	200918|Thermotogae	C	PFAM FMN-binding domain	-	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
CMS1_k127_2172513_2	403833.Pmob_0064	8.488e-84	282.0	COG1347@1|root,COG1347@2|Bacteria,2GCJ2@200918|Thermotogae	200918|Thermotogae	C	Belongs to the NqrDE RnfAE family	-	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS1_k127_2172513_1	665571.STHERM_c03150	6.682e-90	299.0	COG2209@1|root,COG2209@2|Bacteria,2J9VZ@203691|Spirochaetes	203691|Spirochaetes	U	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS1_k127_2172513_0	1307761.L21SP2_2188	2.274e-150	485.0	COG2871@1|root,COG2871@2|Bacteria,2J8WH@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
CMS1_k127_2172513_3	665571.STHERM_c03170	1.136e-51	186.0	2B4IF@1|root,31XAC@2|Bacteria,2JAJT@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2173097_0	216432.CA2559_10688	6.601e-49	183.0	COG0564@1|root,COG0564@2|Bacteria,4NFS8@976|Bacteroidetes,1HXBY@117743|Flavobacteriia	976|Bacteroidetes	J	Pseudouridine synthase	rluC	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
CMS1_k127_2173097_1	632518.Calow_0417	2.796e-33	142.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia,42FMI@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
CMS1_k127_2186138_0	1332071.L581_0799	9.075e-22	107.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,404A4@613|Serratia	1236|Gammaproteobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS1_k127_2186138_1	10224.XP_006813578.1	7.959e-19	95.0	COG4886@1|root,KOG0619@2759|Eukaryota,39TV9@33154|Opisthokonta,3BD7Q@33208|Metazoa,3CYH1@33213|Bilateria	33208|Metazoa	O	negative regulation of toll-like receptor 2 signaling pathway	-	-	-	-	-	-	-	-	-	-	-	-	LRR_8
CMS1_k127_2187767_1	1499967.BAYZ01000039_gene2210	5.195e-15	90.0	COG1512@1|root,COG1512@2|Bacteria	2|Bacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
CMS1_k127_2187767_0	1499967.BAYZ01000039_gene2211	3.752e-88	308.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS1_k127_2195714_4	545695.TREAZ_3224	1.197e-22	102.0	2EJZ1@1|root,33DPM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2195714_6	644968.DFW101_2300	4.456e-05	48.0	2AIDW@1|root,318VA@2|Bacteria,1QF1J@1224|Proteobacteria,43642@68525|delta/epsilon subdivisions,2X0MX@28221|Deltaproteobacteria,2MCVW@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Nif11 domain	-	-	-	-	-	-	-	-	-	-	-	-	Nif11
CMS1_k127_2195714_5	1125700.HMPREF9195_00429	3.358e-07	64.0	COG1196@1|root,COG1566@1|root,COG1196@2|Bacteria,COG1566@2|Bacteria,2J5RV@203691|Spirochaetes	203691|Spirochaetes	D	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein,HTH_38
CMS1_k127_2195714_3	880073.Calab_2594	2.371e-40	157.0	COG0586@1|root,COG0586@2|Bacteria,2NREP@2323|unclassified Bacteria	2|Bacteria	S	SNARE associated Golgi protein	yngC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS1_k127_2195714_1	747365.Thena_0728	8.953e-120	395.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,42FFM@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
CMS1_k127_2195714_2	376686.Fjoh_0919	1.336e-81	282.0	COG3677@1|root,COG3677@2|Bacteria,4NJC5@976|Bacteroidetes,1I0Y5@117743|Flavobacteriia,2NVCC@237|Flavobacterium	976|Bacteroidetes	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
CMS1_k127_2195714_0	1249480.B649_05900	0.0	1277.0	COG0286@1|root,COG0732@1|root,COG0286@2|Bacteria,COG0732@2|Bacteria,1MXPV@1224|Proteobacteria,42QFW@68525|delta/epsilon subdivisions,2YND9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	Type I restriction enzyme R protein N terminus (HSDR_N)	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N_2,N6_Mtase
CMS1_k127_2199755_1	997296.PB1_13609	3.459e-33	139.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,4HDIE@91061|Bacilli,1ZC5Q@1386|Bacillus	91061|Bacilli	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS1_k127_2199755_2	1410626.JHXB01000019_gene1546	1.048e-15	84.0	COG1943@1|root,COG1943@2|Bacteria,1V553@1239|Firmicutes,2495R@186801|Clostridia,27P2J@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
CMS1_k127_2199755_0	1191523.MROS_2695	1.24e-161	520.0	COG0015@1|root,COG0015@2|Bacteria	2|Bacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1095,iSB619.SA_RS09895	ADSL_C,Lyase_1
CMS1_k127_2227537_2	177437.HRM2_42460	1.144e-30	124.0	COG1433@1|root,COG1433@2|Bacteria,1MZ77@1224|Proteobacteria,42U3G@68525|delta/epsilon subdivisions,2WQ5N@28221|Deltaproteobacteria,2MKGB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
CMS1_k127_2227537_3	1232437.KL662012_gene1410	1.073e-09	65.0	COG1433@1|root,COG1433@2|Bacteria,1NCD6@1224|Proteobacteria,42WB8@68525|delta/epsilon subdivisions,2WRAM@28221|Deltaproteobacteria,2MKYT@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
CMS1_k127_2227537_1	102129.Lepto7375DRAFT_8378	1.788e-115	386.0	COG0798@1|root,COG0798@2|Bacteria,1G0WQ@1117|Cyanobacteria	1117|Cyanobacteria	P	sodium bile acid symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SBF
CMS1_k127_2227537_0	760568.Desku_2155	1.343e-164	528.0	COG3829@1|root,COG3829@2|Bacteria,1V0EF@1239|Firmicutes,24DXA@186801|Clostridia	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
CMS1_k127_2235035_0	221288.JH992901_gene1423	5.138e-136	459.0	COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1G4QT@1117|Cyanobacteria,1JJWQ@1189|Stigonemataceae	1117|Cyanobacteria	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_35,GAF,GAF_2,HATPase_c,HisKA,HisKA_3,PAS_4,Pkinase
CMS1_k127_2235035_1	1379281.AVAG01000010_gene1344	6.727e-35	147.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2WKBG@28221|Deltaproteobacteria,2M7VH@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	PFAM cytochrome c biogenesis protein transmembrane region	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
CMS1_k127_2240924_1	247490.KSU1_B0601	2.317e-104	365.0	COG0464@1|root,COG0464@2|Bacteria,2IYYC@203682|Planctomycetes	203682|Planctomycetes	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS1_k127_2240924_11	1219072.VHA01S_031_00280	9.84e-14	82.0	COG0535@1|root,COG0535@2|Bacteria,1RG5U@1224|Proteobacteria	1224|Proteobacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
CMS1_k127_2240924_8	694427.Palpr_2945	7.795e-24	112.0	2DC1B@1|root,2ZCDD@2|Bacteria,4NRQJ@976|Bacteroidetes,2FT3K@200643|Bacteroidia,22Y5M@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2240924_18	688270.Celal_2278	6.777e-05	50.0	COG1511@1|root,COG3210@1|root,COG5295@1|root,COG1511@2|Bacteria,COG3210@2|Bacteria,COG5295@2|Bacteria,4NPY0@976|Bacteroidetes,1I50Q@117743|Flavobacteriia,1F8SR@104264|Cellulophaga	976|Bacteroidetes	U	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2240924_14	1395513.P343_07890	8.644e-07	58.0	2DM7M@1|root,322RC@2|Bacteria,1V924@1239|Firmicutes,4HJDM@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2240924_3	293826.Amet_0436	1.325e-53	208.0	COG3299@1|root,COG3299@2|Bacteria,1TQXP@1239|Firmicutes,24G9S@186801|Clostridia,36H0T@31979|Clostridiaceae	186801|Clostridia	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
CMS1_k127_2240924_15	160492.XF_1595	4.978e-06	53.0	2E1KI@1|root,32WY0@2|Bacteria,1N2PZ@1224|Proteobacteria,1T09J@1236|Gammaproteobacteria,1XCZJ@135614|Xanthomonadales	1224|Proteobacteria	S	ORF located using Glimmer RBSfinder	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2240924_16	598467.BrE312_2391	6.315e-06	55.0	COG4540@1|root,COG4540@2|Bacteria,1R8K2@1224|Proteobacteria,1S5SG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Baseplate assembly protein	Z012_02075	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2240924_9	926561.KB900624_gene2613	2.226e-18	95.0	2D9AP@1|root,32TSY@2|Bacteria,1VDJB@1239|Firmicutes,24P0F@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2240924_17	1111134.HMPREF1253_1174	1.237e-05	55.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	ypbE	-	-	-	-	-	-	-	-	-	-	-	LysM
CMS1_k127_2240924_19	1484479.DI14_04730	0.0001686	48.0	2EGNE@1|root,33AEJ@2|Bacteria,1VP93@1239|Firmicutes,4HRCV@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2240924_13	1307436.PBF_04385	1.499e-09	64.0	2C1XA@1|root,32W1D@2|Bacteria,1VC0P@1239|Firmicutes,4HMJE@91061|Bacilli,1ZK9B@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2240924_6	1444712.BN1013_02401	2.332e-33	142.0	2DBB8@1|root,2Z867@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3383)	Z012_10460	-	-	-	-	-	-	-	-	-	-	-	DUF3383
CMS1_k127_2240924_4	555779.Dthio_PD3142	6.607e-46	171.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,42S2E@68525|delta/epsilon subdivisions,2WMT9@28221|Deltaproteobacteria,2M8UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
CMS1_k127_2240924_0	589924.Ferp_0317	0.0	1374.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,245PG@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
CMS1_k127_2240924_12	1414720.CBYM010000007_gene1152	4.17e-10	65.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,36KNM@31979|Clostridiaceae	186801|Clostridia	T	Belongs to the anti-sigma-factor antagonist family	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
CMS1_k127_2240924_10	161156.JQKW01000013_gene149	3.484e-15	84.0	COG1463@1|root,COG1463@2|Bacteria,2GGR8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
CMS1_k127_2240924_2	1379698.RBG1_1C00001G0979	3.794e-71	248.0	COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
CMS1_k127_2240924_5	316067.Geob_1541	6.464e-45	173.0	COG0767@1|root,COG0767@2|Bacteria,1RHNJ@1224|Proteobacteria,42SNW@68525|delta/epsilon subdivisions,2WPKT@28221|Deltaproteobacteria,43T2D@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
CMS1_k127_2240924_7	1232410.KI421421_gene3416	4.482e-24	117.0	COG3170@1|root,COG3170@2|Bacteria,1MY6X@1224|Proteobacteria,42TBE@68525|delta/epsilon subdivisions,2WPBV@28221|Deltaproteobacteria,43U5N@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2300867_0	313606.M23134_05475	0.0	1032.0	COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,47MEM@768503|Cytophagia	976|Bacteroidetes	S	Alpha-2-macroglobulin family	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,CarbopepD_reg_2,Plug
CMS1_k127_2300867_2	574375.BAGA_23205	2.159e-59	213.0	COG2091@1|root,COG2091@2|Bacteria,1VEYZ@1239|Firmicutes,4HIVV@91061|Bacilli,1ZHU1@1386|Bacillus	91061|Bacilli	H	Belongs to the P-Pant transferase superfamily	sfp	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
CMS1_k127_2300867_1	1499967.BAYZ01000095_gene4114	1.427e-151	511.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS1_k127_2301887_0	91604.ID47_01080	0.0	1136.0	COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG3321 Polyketide synthase modules and related proteins	-	-	-	ko:K13613,ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,Bac_luciferase,Condensation,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
CMS1_k127_2301887_1	153721.MYP_398	6.781e-176	591.0	COG3321@1|root,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,47XYI@768503|Cytophagia	976|Bacteroidetes	Q	PKS_KR	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS1_k127_2306785_0	1408254.T458_08190	2.636e-07	57.0	COG3027@1|root,COG3027@2|Bacteria,1VFZR@1239|Firmicutes,4HNRI@91061|Bacilli	91061|Bacilli	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
CMS1_k127_230750_0	694427.Palpr_2945	1.241e-30	132.0	2DC1B@1|root,2ZCDD@2|Bacteria,4NRQJ@976|Bacteroidetes,2FT3K@200643|Bacteroidia,22Y5M@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_230750_2	929703.KE386491_gene4012	0.0005975	53.0	28J5T@1|root,2Z91J@2|Bacteria,4NHGX@976|Bacteroidetes,47KK2@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_230750_1	1379281.AVAG01000023_gene1911	6.651e-24	108.0	2DNKW@1|root,32Y18@2|Bacteria,1Q4WS@1224|Proteobacteria,43337@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_230774_3	1408324.JNJK01000019_gene2532	1.003e-64	232.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,27IYS@186928|unclassified Lachnospiraceae	186801|Clostridia	K	PSP1 C-terminal conserved region	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
CMS1_k127_230774_0	641491.DND132_0940	1.762e-214	683.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2M8FJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
CMS1_k127_230774_2	926561.KB900621_gene2738	2.987e-70	247.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,3WAJU@53433|Halanaerobiales	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS1_k127_230774_1	411463.EUBVEN_01619	5.319e-97	323.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,25URC@186806|Eubacteriaceae	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
CMS1_k127_2316272_1	445335.CBN_1865	7.759e-33	145.0	COG0840@1|root,COG3290@1|root,COG0840@2|Bacteria,COG3290@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EQK@31979|Clostridiaceae	186801|Clostridia	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,sCache_3_2
CMS1_k127_2316272_4	1112209.AHVZ01000038_gene30	3.361e-16	81.0	COG1550@1|root,COG1550@2|Bacteria,1N1MV@1224|Proteobacteria,1SAAS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
CMS1_k127_2316272_2	1408303.JNJJ01000108_gene70	3.686e-28	119.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HEC8@91061|Bacilli,1ZDXR@1386|Bacillus	91061|Bacilli	M	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
CMS1_k127_2316272_3	595494.Tola_2509	8.496e-21	102.0	28RCN@1|root,2ZDS1@2|Bacteria,1NGBU@1224|Proteobacteria,1SUS9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1189
CMS1_k127_2316272_0	639282.DEFDS_1796	3.762e-51	195.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K12976,ko:K21572	-	-	-	-	ko00000,ko01000,ko01005,ko02000	8.A.46.1,8.A.46.3	-	-	DUF3138,OMP_b-brl,PagL,SLH,SusD-like_3,SusD_RagB,fn3
CMS1_k127_2318789_2	349521.HCH_00201	3.718e-23	104.0	COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,1RPYT@1236|Gammaproteobacteria,1XHY5@135619|Oceanospirillales	135619|Oceanospirillales	G	ABC transporter substrate-binding protein	thuE	-	-	ko:K10236	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2318789_1	1121104.AQXH01000001_gene2001	2.4e-40	154.0	COG0394@1|root,COG0394@2|Bacteria,4NNQZ@976|Bacteroidetes,1ISM4@117747|Sphingobacteriia	976|Bacteroidetes	T	PFAM Protein-tyrosine phosphatase, low molecular weight	ptpA	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
CMS1_k127_2318789_0	1200557.JHWV01000011_gene1033	1.519e-67	239.0	COG3001@1|root,COG3001@2|Bacteria,1U79A@1239|Firmicutes,4H6NC@909932|Negativicutes	909932|Negativicutes	G	Fructosamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
CMS1_k127_2352092_4	309803.CTN_0771	1.145e-05	57.0	COG0296@1|root,COG0296@2|Bacteria,2GD7U@200918|Thermotogae	200918|Thermotogae	G	PFAM glycoside hydrolase, family 13 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
CMS1_k127_2352092_3	1395513.P343_17330	1.488e-16	87.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,26PMA@186821|Sporolactobacillaceae	91061|Bacilli	NT	histidine kinase HAMP region domain protein	mcpA3	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
CMS1_k127_2352092_1	398767.Glov_1382	2.982e-102	344.0	COG1996@1|root,COG1996@2|Bacteria,1QV33@1224|Proteobacteria,43CNA@68525|delta/epsilon subdivisions,2X7VK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2352092_0	313628.LNTAR_24551	3.006e-140	455.0	COG4260@1|root,COG4260@2|Bacteria	2|Bacteria	N	virion core protein, lumpy skin disease virus	ydjI	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339
CMS1_k127_2352092_2	644801.Psest_0860	1.945e-58	222.0	COG0366@1|root,COG0366@2|Bacteria,1PDY7@1224|Proteobacteria,1T9BF@1236|Gammaproteobacteria,1Z1QT@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.60	ko:K22253	-	-	-	-	ko00000,ko01000	-	CBM20,GH13	-	Alpha-amylase,CBM_20,DUF1921
CMS1_k127_2353184_2	373903.Hore_00410	1.912e-102	344.0	COG1609@1|root,COG1609@2|Bacteria,1TRFH@1239|Firmicutes,25KFG@186801|Clostridia,3WBHD@53433|Halanaerobiales	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
CMS1_k127_2353184_0	1151117.AJLF01000002_gene430	1.003e-125	417.0	COG1653@1|root,arCOG00151@2157|Archaea,2Y0AI@28890|Euryarchaeota,243YU@183968|Thermococci	183968|Thermococci	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
CMS1_k127_2353184_3	935837.JAEK01000034_gene3037	5.394e-74	259.0	COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,4HBEF@91061|Bacilli,1ZQ7P@1386|Bacillus	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	M1-465	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_2353184_1	748449.Halha_1828	3.469e-103	342.0	COG0395@1|root,COG0395@2|Bacteria,1TR0I@1239|Firmicutes,24AZD@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
CMS1_k127_2364901_1	1485544.JQKP01000005_gene405	3.965e-14	76.0	COG3713@1|root,COG3713@2|Bacteria,1R5JE@1224|Proteobacteria,2VKVW@28216|Betaproteobacteria,44WAS@713636|Nitrosomonadales	28216|Betaproteobacteria	M	MltA-interacting protein MipA	-	-	-	-	-	-	-	-	-	-	-	-	MipA
CMS1_k127_2364901_0	1278307.KB906979_gene3736	6.315e-87	301.0	COG0515@1|root,COG0515@2|Bacteria,1R4X3@1224|Proteobacteria,1RSH9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2376798_2	1249627.D779_2003	4.568e-120	410.0	COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WX3E@135613|Chromatiales	135613|Chromatiales	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_4,sCache_2
CMS1_k127_2376798_1	1450525.JATV01000004_gene65	3.717e-126	420.0	COG4262@1|root,COG4262@2|Bacteria,4NFVH@976|Bacteroidetes,1HZRY@117743|Flavobacteriia,2NV5R@237|Flavobacterium	976|Bacteroidetes	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
CMS1_k127_2376798_7	378806.STAUR_1794	6.593e-13	71.0	2DI1Z@1|root,301RV@2|Bacteria,1NM7Q@1224|Proteobacteria,433HJ@68525|delta/epsilon subdivisions,2WXZG@28221|Deltaproteobacteria,2Z1QD@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of Unknown Function (DUF350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
CMS1_k127_2376798_9	204669.Acid345_0107	1.6e-05	57.0	COG1379@1|root,COG1379@2|Bacteria,3Y7H3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4178
CMS1_k127_2376798_6	267608.RSp1295	3.409e-26	115.0	COG1379@1|root,COG1379@2|Bacteria,1MVED@1224|Proteobacteria,2VJM0@28216|Betaproteobacteria,1K4MC@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4178
CMS1_k127_2376798_8	376686.Fjoh_2579	7.689e-10	66.0	2C257@1|root,32ZG0@2|Bacteria,4PBVJ@976|Bacteroidetes,1I65U@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2376798_4	1346330.M472_13855	3.034e-36	156.0	COG3177@1|root,COG3177@2|Bacteria,4NR8T@976|Bacteroidetes,1IYNY@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
CMS1_k127_2376798_0	999541.bgla_2g07550	4.168e-170	560.0	COG3177@1|root,COG3177@2|Bacteria,1RJSD@1224|Proteobacteria,2W351@28216|Betaproteobacteria,1KEA3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
CMS1_k127_2376798_3	697303.Thewi_1542	2.166e-72	256.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42IAI@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	ADC,Oxidored_FMN,Pyr_redox_2
CMS1_k127_2376798_5	1385510.N781_06580	3.027e-34	136.0	COG4446@1|root,COG4446@2|Bacteria,1VDZG@1239|Firmicutes,4HN9R@91061|Bacilli,2YAKS@289201|Pontibacillus	91061|Bacilli	S	Protein of unknown function (DUF1499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
CMS1_k127_2381271_4	1403819.BATR01000162_gene5329	5.514e-50	188.0	2DZNQ@1|root,32VEU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2381271_0	744872.Spica_2702	1.633e-219	692.0	COG0286@1|root,COG0286@2|Bacteria,2J6AA@203691|Spirochaetes	203691|Spirochaetes	V	type I restriction-modification system	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
CMS1_k127_2381271_6	504472.Slin_2152	2.352e-37	144.0	COG3177@1|root,COG3177@2|Bacteria,4NFBY@976|Bacteroidetes,47MWT@768503|Cytophagia	976|Bacteroidetes	K	PFAM Fic DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
CMS1_k127_2381271_3	1408473.JHXO01000003_gene2544	1.407e-50	186.0	COG1943@1|root,COG1943@2|Bacteria,4NTCS@976|Bacteroidetes,2FV24@200643|Bacteroidia	976|Bacteroidetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
CMS1_k127_2381271_1	926692.AZYG01000047_gene2645	2.415e-151	484.0	COG3943@1|root,COG3943@2|Bacteria,1TPH4@1239|Firmicutes,248NI@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_RhuM
CMS1_k127_2381271_2	1414720.CBYM010000005_gene1340	8.565e-86	299.0	COG0732@1|root,COG0732@2|Bacteria,1V66H@1239|Firmicutes,24BNF@186801|Clostridia,36N74@31979|Clostridiaceae	186801|Clostridia	V	Type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
CMS1_k127_2381271_5	340177.Cag_1611	1.626e-40	152.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K18491	ko04550,map04550	-	-	-	ko00000,ko00001,ko03000	-	-	-	AAA_21
CMS1_k127_2428503_1	313598.MED152_13459	6.221e-75	258.0	2CI1G@1|root,2Z7JA@2|Bacteria,4NF1T@976|Bacteroidetes,1HY5I@117743|Flavobacteriia,3VW2J@52959|Polaribacter	976|Bacteroidetes	S	Domain of unknown function (DUF4294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4294
CMS1_k127_2428503_0	1296415.JACC01000015_gene830	5.294e-207	646.0	COG1363@1|root,COG1363@2|Bacteria,4NG97@976|Bacteroidetes,1HWZT@117743|Flavobacteriia,2YHA9@290174|Aquimarina	976|Bacteroidetes	G	M42 glutamyl aminopeptidase	frvX	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
CMS1_k127_2428503_2	555500.I215_05462	1.169e-31	125.0	COG1443@1|root,COG1443@2|Bacteria,4NRS2@976|Bacteroidetes,1I2UY@117743|Flavobacteriia	976|Bacteroidetes	I	Hydrolase of MutT (Nudix) family protein	idi	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS1_k127_2494744_1	665571.STHERM_c04790	1.383e-28	127.0	2B518@1|root,31XUG@2|Bacteria,2JAMI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2494744_0	1123009.AUID01000002_gene2144	3.617e-187	591.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,268CF@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location Cytoplasmic, score	norV	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
CMS1_k127_2495693_0	1293054.HSACCH_02011	8.387e-124	409.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,3WA8K@53433|Halanaerobiales	186801|Clostridia	J	tRNA synthetase class II core domain (G, H, P, S and T)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
CMS1_k127_2495693_1	373903.Hore_05840	3.61e-98	334.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,3WAAA@53433|Halanaerobiales	186801|Clostridia	O	PFAM Peptidase family U32	yhbU_1	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
CMS1_k127_2495693_2	456320.Mvol_0136	8.661e-91	307.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,23QRX@183939|Methanococci	183939|Methanococci	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
CMS1_k127_2495693_3	289376.THEYE_A1649	2.094e-71	249.0	COG0289@1|root,COG0289@2|Bacteria,3J0IJ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
CMS1_k127_2526637_1	443143.GM18_2046	1.313e-11	77.0	COG1538@1|root,COG1538@2|Bacteria,1MWQK@1224|Proteobacteria,42UQA@68525|delta/epsilon subdivisions,2WQXF@28221|Deltaproteobacteria,43TDQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	MU	PFAM outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS1_k127_2526637_2	1499684.CCNP01000023_gene3138	1.875e-10	70.0	COG1309@1|root,COG1309@2|Bacteria,1V6GJ@1239|Firmicutes,24J0S@186801|Clostridia,36JXP@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_2526637_0	1120998.AUFC01000008_gene1102	6.28e-75	260.0	COG1243@1|root,COG1243@2|Bacteria,1TS1F@1239|Firmicutes,248YV@186801|Clostridia	186801|Clostridia	BK	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,Radical_SAM_C
CMS1_k127_2529508_11	945713.IALB_3081	5.61e-24	110.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	ccmA	-	3.6.3.41	ko:K01990,ko:K02193	ko02010,map02010	M00254,M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.107	-	-	ABC_tran
CMS1_k127_2529508_14	1379698.RBG1_1C00001G0423	3.09e-14	81.0	COG2386@1|root,COG2386@2|Bacteria,2NPHG@2323|unclassified Bacteria	2|Bacteria	O	CcmB protein	ccmB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193,ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	iECO111_1330.ECO111_2936,iYL1228.KPN_02080	CcmB
CMS1_k127_2529508_8	1123288.SOV_2c11650	1.8e-40	157.0	COG0755@1|root,COG0755@2|Bacteria,1V4A6@1239|Firmicutes,4H45W@909932|Negativicutes	909932|Negativicutes	O	Cytochrome c assembly protein	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
CMS1_k127_2529508_15	316274.Haur_2721	4.374e-13	74.0	COG2332@1|root,COG2332@2|Bacteria,2GAFQ@200795|Chloroflexi,375YM@32061|Chloroflexia	32061|Chloroflexia	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
CMS1_k127_2529508_7	1499967.BAYZ01000074_gene2131	3.354e-47	181.0	COG0385@1|root,COG0385@2|Bacteria	2|Bacteria	S	bile acid:sodium symporter activity	yfeH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.58	ko:K00041,ko:K03453,ko:K14347	ko00040,ko01100,map00040,map01100	M00631	R02555	RC00085	ko00000,ko00001,ko00002,ko01000,ko02000,ko04147	2.A.28,2.A.93.1	-	iYO844.BSU19350	SBF,SBF_like
CMS1_k127_2529508_0	313628.LNTAR_20808	3.581e-145	466.0	COG0180@1|root,COG0180@2|Bacteria	2|Bacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
CMS1_k127_2529508_10	1455608.JDTH01000005_gene2751	7.936e-36	151.0	COG0477@1|root,arCOG00130@2157|Archaea,2XT6G@28890|Euryarchaeota,23SC5@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_2529508_2	573061.Clocel_3456	9.405e-121	396.0	COG0189@1|root,COG2918@1|root,COG0189@2|Bacteria,COG2918@2|Bacteria,1TPGX@1239|Firmicutes,25ER3@186801|Clostridia,36URU@31979|Clostridiaceae	186801|Clostridia	HJ	belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily	gshF	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase,RimK
CMS1_k127_2529508_1	868131.MSWAN_1111	2.981e-126	419.0	COG2918@1|root,arCOG10328@2157|Archaea,2XXK3@28890|Euryarchaeota,23P1P@183925|Methanobacteria	183925|Methanobacteria	H	Glutamate-cysteine ligase	gshF	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
CMS1_k127_2529508_13	1121423.JONT01000001_gene2135	1.793e-20	92.0	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,24R29@186801|Clostridia,26375@186807|Peptococcaceae	186801|Clostridia	O	PFAM nitrogen-fixing NifU domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NifU
CMS1_k127_2529508_9	926561.KB900622_gene619	4.592e-39	150.0	COG1959@1|root,COG1959@2|Bacteria,1VG7P@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS1_k127_2529508_12	1469948.JPNB01000002_gene2966	5.791e-23	99.0	COG1148@1|root,COG1148@2|Bacteria,1UI0M@1239|Firmicutes,25E99@186801|Clostridia,36UQT@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS1_k127_2529508_6	123214.PERMA_0311	4.074e-54	202.0	COG1522@1|root,COG1522@2|Bacteria,2G4TH@200783|Aquificae	200783|Aquificae	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2529508_4	1243664.CAVL020000036_gene2703	1.699e-108	361.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,4HAY2@91061|Bacilli,1ZBK3@1386|Bacillus	91061|Bacilli	C	Fe-S oxidoreductases	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS1_k127_2529508_5	1123376.AUIU01000019_gene1250	1.517e-83	293.0	COG0373@1|root,COG0373@2|Bacteria,3J0BD@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
CMS1_k127_2529508_3	1232410.KI421418_gene2222	8.506e-116	387.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2WJZA@28221|Deltaproteobacteria,43U55@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sodium:neurotransmitter symporter family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
CMS1_k127_2530353_1	1048983.EL17_07030	5.107e-63	225.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	suhB	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
CMS1_k127_2530353_0	1541065.JRFE01000014_gene1510	3.115e-83	289.0	COG3287@1|root,COG3287@2|Bacteria,1G0HF@1117|Cyanobacteria,3VNGD@52604|Pleurocapsales	1117|Cyanobacteria	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
CMS1_k127_2530353_2	443254.Marpi_1426	1.07e-20	102.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	DHODB_Fe-S_bind,Fer4_22,HATPase_c,HisKA,NAD_binding_1,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS1_k127_2530353_3	1000565.METUNv1_02928	3.799e-10	61.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,2KVSQ@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
CMS1_k127_253238_2	1123288.SOV_2c07790	1.289e-42	158.0	COG3123@1|root,COG3123@2|Bacteria,1VBF3@1239|Firmicutes,4H5FV@909932|Negativicutes	909932|Negativicutes	S	Protein of unknown function (DUF1255)	-	-	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
CMS1_k127_253238_3	545694.TREPR_2960	1.639e-05	54.0	COG1462@1|root,COG1462@2|Bacteria	2|Bacteria	M	curli production assembly transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
CMS1_k127_253238_1	665571.STHERM_c02670	3.955e-151	490.0	COG0205@1|root,COG0205@2|Bacteria,2J6KH@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
CMS1_k127_253238_0	926561.KB900617_gene1903	6.454e-191	608.0	COG0366@1|root,COG0366@2|Bacteria,1V0U1@1239|Firmicutes,24ZQ4@186801|Clostridia	186801|Clostridia	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
CMS1_k127_2550471_2	1121441.AUCX01000003_gene2948	2.006e-27	117.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS1_k127_2550471_1	1121324.CLIT_4c00830	1.715e-126	408.0	COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,25QC8@186804|Peptostreptococcaceae	186801|Clostridia	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
CMS1_k127_2550471_0	944479.JQLX01000018_gene191	9.119e-127	423.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2M7IE@213113|Desulfurellales	28221|Deltaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
CMS1_k127_2550744_0	1384484.AEQU_0737	4.532e-60	211.0	COG2131@1|root,COG2131@2|Bacteria,2IJ94@201174|Actinobacteria,4CVRR@84998|Coriobacteriia	84998|Coriobacteriia	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
CMS1_k127_2550744_2	1492737.FEM08_18840	9.842e-07	59.0	COG0457@1|root,COG0457@2|Bacteria,4NG9G@976|Bacteroidetes,1HYXF@117743|Flavobacteriia,2NTRA@237|Flavobacterium	976|Bacteroidetes	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_8
CMS1_k127_2550744_1	402777.KB235904_gene3411	7.08e-37	161.0	COG0457@1|root,COG1215@1|root,COG1216@1|root,COG0457@2|Bacteria,COG1215@2|Bacteria,COG1216@2|Bacteria,1GQBE@1117|Cyanobacteria,1H7DT@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2,RgpF,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8
CMS1_k127_2556461_11	1121335.Clst_0558	1.115e-21	103.0	COG4915@1|root,COG4915@2|Bacteria	2|Bacteria	S	5-bromo-4-chloroindolyl phosphate hydrolysis protein	xpaC	-	-	-	-	-	-	-	-	-	-	-	Halogen_Hydrol
CMS1_k127_2556461_3	1121289.JHVL01000014_gene1801	2.14e-111	372.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,36E7B@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
CMS1_k127_2556461_0	91464.S7335_2184	2.133e-224	712.0	COG0021@1|root,COG0021@2|Bacteria,1G0B5@1117|Cyanobacteria,1H2HG@1129|Synechococcus	1117|Cyanobacteria	G	Transketolase, thiamine diphosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
CMS1_k127_2556461_7	272563.CD630_34380	9.092e-52	188.0	COG2087@1|root,COG2087@2|Bacteria,1V6F8@1239|Firmicutes,24JF6@186801|Clostridia,25RRM@186804|Peptostreptococcaceae	186801|Clostridia	H	Cobinamide kinase / cobinamide phosphate guanyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
CMS1_k127_2556461_8	1301100.HG529436_gene6562	4.404e-43	167.0	COG0368@1|root,COG0368@2|Bacteria,1V1QB@1239|Firmicutes,24I0D@186801|Clostridia,36H10@31979|Clostridiaceae	186801|Clostridia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
CMS1_k127_2556461_10	203119.Cthe_3153	7.043e-38	149.0	COG0406@1|root,COG0406@2|Bacteria,1VEMM@1239|Firmicutes,24GJW@186801|Clostridia	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	cobC	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
CMS1_k127_2556461_1	398512.JQKC01000008_gene860	4.742e-167	539.0	COG1492@1|root,COG1492@2|Bacteria,1TP5E@1239|Firmicutes,248XW@186801|Clostridia,3WHB7@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15780	AAA_26,CbiA,GATase_3
CMS1_k127_2556461_5	526218.Sterm_1019	9.486e-72	253.0	COG1270@1|root,COG1270@2|Bacteria,3794J@32066|Fusobacteria	32066|Fusobacteria	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
CMS1_k127_2556461_4	1391647.AVSV01000027_gene2838	6.82e-73	259.0	COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,36DWQ@31979|Clostridiaceae	186801|Clostridia	E	PFAM aminotransferase class I and II	cobD_2	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
CMS1_k127_2556461_2	857293.CAAU_1833	3.575e-118	389.0	COG2038@1|root,COG2038@2|Bacteria,1TPC1@1239|Firmicutes,25DH5@186801|Clostridia,36DYX@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
CMS1_k127_2556461_6	439235.Dalk_0815	8.178e-61	216.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2MNC9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS1_k127_2556461_9	1191523.MROS_0856	7.906e-40	154.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
CMS1_k127_2556583_1	509191.AEDB02000050_gene4436	5.833e-06	55.0	COG1595@1|root,COG1595@2|Bacteria,1V8Z0@1239|Firmicutes,24MIS@186801|Clostridia,3WM1J@541000|Ruminococcaceae	186801|Clostridia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_2556583_2	491205.JARQ01000005_gene1733	2.838e-05	55.0	COG3279@1|root,COG3279@2|Bacteria,4NI3K@976|Bacteroidetes,1HZ0N@117743|Flavobacteriia	976|Bacteroidetes	T	Response regulator of the LytR AlgR family	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
CMS1_k127_2556583_0	313628.LNTAR_03854	2.289e-46	171.0	COG1671@1|root,COG1671@2|Bacteria	2|Bacteria	S	Uncharacterized BCR, YaiI/YqxD family COG1671	yaiI	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
CMS1_k127_2565209_0	1123487.KB892857_gene2411	1.111e-17	88.0	COG3713@1|root,COG3713@2|Bacteria,1R5JE@1224|Proteobacteria,2VKVW@28216|Betaproteobacteria,2KVV9@206389|Rhodocyclales	206389|Rhodocyclales	M	MltA-interacting protein MipA	-	-	-	-	-	-	-	-	-	-	-	-	MipA
CMS1_k127_2565209_1	5932.XP_004027221.1	4.757e-10	72.0	COG4642@1|root,COG5253@1|root,KOG0229@2759|Eukaryota,KOG0231@2759|Eukaryota	2759|Eukaryota	DZ	MORN repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	MORN
CMS1_k127_2566377_3	279010.BL01952	1.451e-42	159.0	COG0346@1|root,COG0346@2|Bacteria,1V4NM@1239|Firmicutes,4HXH2@91061|Bacilli,1ZQGZ@1386|Bacillus	91061|Bacilli	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
CMS1_k127_2566377_1	1321778.HMPREF1982_04107	3.377e-71	249.0	COG1378@1|root,COG1378@2|Bacteria	2|Bacteria	K	Sugar-specific transcriptional regulator TrmB	yrhO1	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
CMS1_k127_2566377_2	1232437.KL662062_gene4231	7.858e-54	196.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,42RT9@68525|delta/epsilon subdivisions,2WNJ0@28221|Deltaproteobacteria,2MIGR@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_1658	Fer4_14,Radical_SAM
CMS1_k127_2566377_4	1443122.Z958_12100	4.448e-23	109.0	COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,36DKI@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS1_k127_2566377_0	653948.CCA14155	2.021e-80	283.0	COG0464@1|root,KOG0730@2759|Eukaryota	2759|Eukaryota	O	ATP binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS1_k127_2579269_0	936140.AEOT01000013_gene369	9.393e-13	79.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
CMS1_k127_2579269_1	1217656.F964_02692	3.324e-09	68.0	COG3756@1|root,COG3756@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1376,HTH_36,Phage_rep_O
CMS1_k127_2585970_1	926562.Oweho_2082	3.728e-30	141.0	COG3209@1|root,COG3209@2|Bacteria,4NE5D@976|Bacteroidetes,1HYTK@117743|Flavobacteriia,2PB8R@246874|Cryomorphaceae	976|Bacteroidetes	M	TIGRFAM RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	TSP_3
CMS1_k127_2585970_0	1403819.BATR01000053_gene1641	8.868e-33	150.0	COG3209@1|root,COG3209@2|Bacteria,46UCN@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Insecticide toxin TcdB middle/N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,VCBS
CMS1_k127_2585970_3	1307761.L21SP2_3313	6.944e-11	66.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
CMS1_k127_2585970_4	1047013.AQSP01000144_gene887	1.229e-06	52.0	COG1484@1|root,COG1484@2|Bacteria,2NPM0@2323|unclassified Bacteria	2|Bacteria	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CMS1_k127_2585970_2	509191.AEDB02000073_gene2010	1.021e-14	76.0	COG2942@1|root,COG2942@2|Bacteria	2|Bacteria	G	2-epimerase	VPA0780	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
CMS1_k127_2586151_0	880073.Calab_1855	1.189e-181	585.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2NNW8@2323|unclassified Bacteria	2|Bacteria	L	DNA helicase	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
CMS1_k127_2586151_2	522772.Dacet_2584	1.138e-05	54.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	DUF1153,HTH_28,HTH_Tnp_1,rve
CMS1_k127_2586151_1	290512.Paes_1100	5.184e-14	76.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,HTH_32,rve,rve_3
CMS1_k127_2589323_0	157072.XP_008861208.1	3.247e-130	441.0	28VX6@1|root,2R2P1@2759|Eukaryota	2759|Eukaryota	S	Metallo-beta-lactamase superfamily	-	GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006198,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008081,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009187,GO:0009214,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019932,GO:0019933,GO:0019934,GO:0019935,GO:0023052,GO:0032101,GO:0033036,GO:0034404,GO:0034613,GO:0034641,GO:0034654,GO:0034655,GO:0035556,GO:0040012,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046058,GO:0046434,GO:0046483,GO:0046700,GO:0047555,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0050926,GO:0051179,GO:0051641,GO:0051716,GO:0055086,GO:0061118,GO:0065007,GO:0070727,GO:0071704,GO:0072521,GO:0072523,GO:0072697,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1990778	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2,cNMP_binding
CMS1_k127_2597210_0	945713.IALB_0828	1.149e-13	75.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	btrV	-	-	ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
CMS1_k127_2597210_1	1519464.HY22_03185	2.486e-09	64.0	COG2172@1|root,COG2172@2|Bacteria,1FFGV@1090|Chlorobi	1090|Chlorobi	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
CMS1_k127_2602802_1	1301100.HG529435_gene6502	9.147e-63	224.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,36DP0@31979|Clostridiaceae	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
CMS1_k127_2602802_0	759914.BP951000_0384	1.977e-79	274.0	COG1655@1|root,COG1655@2|Bacteria,2J5GN@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria	-	-	-	ko:K09766	-	-	-	-	ko00000	-	-	-	DUF2225
CMS1_k127_2603146_0	273121.WS1354	1.815e-152	489.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2YMDC@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
CMS1_k127_2603146_1	373903.Hore_12780	1.792e-34	143.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,3WBPR@53433|Halanaerobiales	186801|Clostridia	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
CMS1_k127_2603146_2	1123322.KB904650_gene1797	1.892e-23	114.0	COG2182@1|root,COG2182@2|Bacteria,2I2J8@201174|Actinobacteria	201174|Actinobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_2603872_0	526218.Sterm_2031	7.058e-53	192.0	COG0172@1|root,COG0172@2|Bacteria,378ZK@32066|Fusobacteria	32066|Fusobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
CMS1_k127_2603872_1	1123376.AUIU01000016_gene335	4.579e-09	67.0	COG0457@1|root,COG0457@2|Bacteria,3J0MH@40117|Nitrospirae	40117|Nitrospirae	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
CMS1_k127_2603872_2	1121396.KB893081_gene1756	7.891e-08	65.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2MJAV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8,zinc_ribbon_4
CMS1_k127_2604546_0	1239962.C943_04304	2.261e-277	861.0	COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,47KPV@768503|Cytophagia	976|Bacteroidetes	C	Aldehyde oxidase and xanthine dehydrogenase molybdopterin binding	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
CMS1_k127_2604546_2	1121011.AUCB01000029_gene2218	1.495e-36	145.0	COG2068@1|root,COG2068@2|Bacteria,4NQNF@976|Bacteroidetes,1I2S6@117743|Flavobacteriia,23HHP@178469|Arenibacter	976|Bacteroidetes	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
CMS1_k127_2604546_1	1168034.FH5T_21130	1.351e-61	215.0	COG1975@1|root,COG1975@2|Bacteria,4NG02@976|Bacteroidetes	976|Bacteroidetes	O	maturation factor XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
CMS1_k127_2606840_1	1203611.KB894551_gene937	6.463e-67	237.0	COG1726@1|root,COG1726@2|Bacteria,4NEDQ@976|Bacteroidetes,2FN6J@200643|Bacteroidia,22U7U@171550|Rikenellaceae	976|Bacteroidetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	-	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
CMS1_k127_2606840_0	243231.GSU0156	6.101e-149	484.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,43TB5@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	PFAM fumarate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1,NUDIX
CMS1_k127_2606840_2	926569.ANT_00480	1.723e-38	152.0	COG1285@1|root,COG1285@2|Bacteria,2G77U@200795|Chloroflexi	200795|Chloroflexi	S	PFAM MgtC SapB transporter	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
CMS1_k127_2612803_1	1123274.KB899407_gene382	5.734e-43	168.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2,zinc_ribbon_2
CMS1_k127_2612803_0	889378.Spiaf_2847	6.028e-47	176.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA,RDD,Yop-YscD_cpl
CMS1_k127_2622643_10	5679.XP_010702947.1	0.0003587	53.0	COG0457@1|root,KOG4648@2759|Eukaryota,3XTS5@5653|Kinetoplastida	5653|Kinetoplastida	S	Stress-inducible protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
CMS1_k127_2622643_2	316067.Geob_1877	1.234e-104	359.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,43TDN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
CMS1_k127_2622643_5	580332.Slit_1477	8.828e-67	231.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2VI7G@28216|Betaproteobacteria,44VQ2@713636|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003999,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0012505,GO:0016192,GO:0016208,GO:0016740,GO:0016757,GO:0016763,GO:0017076,GO:0018130,GO:0019438,GO:0030141,GO:0030554,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0043094,GO:0043101,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046483,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
CMS1_k127_2622643_1	880073.Calab_3781	6.322e-142	458.0	COG0057@1|root,COG0057@2|Bacteria,2NNPP@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
CMS1_k127_2622643_4	880073.Calab_3779	5.603e-80	274.0	COG0149@1|root,COG0149@2|Bacteria,2NP24@2323|unclassified Bacteria	2|Bacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
CMS1_k127_2622643_9	1123274.KB899419_gene1973	8.943e-07	55.0	COG1314@1|root,COG1314@2|Bacteria,2J7UR@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
CMS1_k127_2622643_0	338966.Ppro_0044	7.777e-155	497.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,43TWM@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CMS1_k127_2622643_6	1045858.Bint_1622	2.202e-30	128.0	COG0811@1|root,COG0811@2|Bacteria,2J700@203691|Spirochaetes	203691|Spirochaetes	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CMS1_k127_2622643_8	639282.DEFDS_1264	2.852e-14	78.0	COG0848@1|root,COG0848@2|Bacteria,2GFX6@200930|Deferribacteres	200930|Deferribacteres	U	Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
CMS1_k127_2622643_3	759914.BP951000_1164	6.978e-84	309.0	COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
CMS1_k127_2622643_7	177437.HRM2_27220	5.397e-22	98.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MKCK@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
CMS1_k127_2636994_0	880073.Calab_0899	2.523e-153	497.0	COG0514@1|root,COG0514@2|Bacteria,2NNZU@2323|unclassified Bacteria	2|Bacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,Pribosyltran,RQC,RecQ_Zn_bind
CMS1_k127_2636994_1	1157708.KB907452_gene3861	3.915e-12	73.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,2VKZ3@28216|Betaproteobacteria,4AB1D@80864|Comamonadaceae	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CMS1_k127_2666425_0	309799.DICTH_1761	3.712e-07	59.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	qacR	-	-	-	-	-	-	-	-	-	-	-	TetR_C_5,TetR_N
CMS1_k127_2676278_0	370438.PTH_2292	3.093e-140	467.0	COG0471@1|root,COG0664@1|root,COG0471@2|Bacteria,COG0664@2|Bacteria,1VBPG@1239|Firmicutes,25N3S@186801|Clostridia,263S9@186807|Peptococcaceae	186801|Clostridia	P	PFAM Sodium sulfate symporter transmembrane region	-	-	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	Na_sulph_symp
CMS1_k127_2676278_1	370438.PTH_2291	6.506e-89	304.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
CMS1_k127_2676278_2	525897.Dbac_1831	5.936e-05	47.0	COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHBV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
CMS1_k127_2677466_1	765869.BDW_02625	8.344e-24	106.0	COG2259@1|root,COG2259@2|Bacteria,1NCQT@1224|Proteobacteria,42WUM@68525|delta/epsilon subdivisions,2MTDS@213481|Bdellovibrionales,2WT9R@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
CMS1_k127_2677466_0	1321778.HMPREF1982_03495	8.214e-59	218.0	COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,249J5@186801|Clostridia	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxX,Pyr_redox_2
CMS1_k127_2677466_2	335543.Sfum_3718	1.314e-16	82.0	COG0764@1|root,COG0764@2|Bacteria,1NQA9@1224|Proteobacteria,42X92@68525|delta/epsilon subdivisions,2WT9Z@28221|Deltaproteobacteria,2MSDC@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	FabA-like domain	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
CMS1_k127_2678666_0	522772.Dacet_1852	8.945e-44	164.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2GEMQ@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
CMS1_k127_2678965_1	56780.SYN_00140	7.196e-42	166.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MRC1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS1_k127_2678965_0	526227.Mesil_0175	1.852e-96	325.0	COG0009@1|root,COG0009@2|Bacteria,1WJN4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Sua5 YciO YrdC YwlC family protein	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
CMS1_k127_2678965_2	338963.Pcar_1024	3.607e-15	85.0	COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,42RW8@68525|delta/epsilon subdivisions,2WNP6@28221|Deltaproteobacteria,43SGH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Etoposide-induced protein 2.4 (EI24)	-	-	-	ko:K06203	-	-	-	-	ko00000	-	-	-	EI24
CMS1_k127_2678965_3	1121947.AUHK01000040_gene393	0.0001172	44.0	COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia,22HCP@1570339|Peptoniphilaceae	186801|Clostridia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
CMS1_k127_2700327_1	1120980.JQKH01000109_gene972	5.321e-136	440.0	COG0616@1|root,COG0616@2|Bacteria,1Q17C@1224|Proteobacteria,2W689@28216|Betaproteobacteria	28216|Betaproteobacteria	OU	signal peptide processing	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2700327_0	1216932.CM240_0790	1.634e-181	614.0	COG0366@1|root,COG1501@1|root,COG0366@2|Bacteria,COG1501@2|Bacteria,1TP9E@1239|Firmicutes,248DX@186801|Clostridia,36DSD@31979|Clostridiaceae	186801|Clostridia	G	Alpha-amylase domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26
CMS1_k127_2700455_2	929558.SMGD1_2071	1.036e-27	125.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S84@68525|delta/epsilon subdivisions,2YPD4@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_8,dCache_3
CMS1_k127_2700455_1	717774.Marme_3303	3.104e-34	141.0	COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,1RP5T@1236|Gammaproteobacteria,1XJJZ@135619|Oceanospirillales	135619|Oceanospirillales	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS1_k127_2700455_0	555079.Toce_2177	2.99e-56	208.0	COG0616@1|root,COG0616@2|Bacteria,1TRQW@1239|Firmicutes,24BP1@186801|Clostridia,42G2U@68295|Thermoanaerobacterales	186801|Clostridia	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
CMS1_k127_2700827_3	69014.TK0836	9.045e-49	179.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,24415@183968|Thermococci	183968|Thermococci	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
CMS1_k127_2700827_0	1158318.ATXC01000001_gene1090	8.839e-201	637.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G3NT@200783|Aquificae	200783|Aquificae	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
CMS1_k127_2700827_2	1089553.Tph_c07150	4.554e-52	188.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,42GC6@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
CMS1_k127_2700827_1	716544.wcw_1136	8.971e-68	258.0	COG0642@1|root,COG3290@1|root,COG3452@1|root,COG2205@2|Bacteria,COG3290@2|Bacteria,COG3452@2|Bacteria,2JG61@204428|Chlamydiae	204428|Chlamydiae	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS1_k127_2700827_5	290397.Adeh_2009	1.63e-13	83.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
CMS1_k127_2700827_4	641524.ADICYQ_1773	1.06e-31	140.0	COG0860@1|root,COG0860@2|Bacteria,4NGF0@976|Bacteroidetes,47XQ3@768503|Cytophagia	976|Bacteroidetes	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
CMS1_k127_2708222_5	452471.Aasi_1795	3.826e-31	124.0	COG1373@1|root,COG1373@2|Bacteria,4NE39@976|Bacteroidetes,47KTC@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
CMS1_k127_2708222_2	1168289.AJKI01000030_gene1197	1.141e-111	370.0	COG0709@1|root,COG0709@2|Bacteria,4NI4R@976|Bacteroidetes,2FRGC@200643|Bacteroidia,3XIPW@558415|Marinilabiliaceae	976|Bacteroidetes	E	AIR synthase related protein, N-terminal domain	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
CMS1_k127_2708222_6	56780.SYN_00373	7.13e-07	53.0	COG0822@1|root,COG0822@2|Bacteria,1QV9Q@1224|Proteobacteria,43BNX@68525|delta/epsilon subdivisions,2X709@28221|Deltaproteobacteria	2|Bacteria	C	Protein of unknown function (DUF3343)	-	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	DUF3343,Fer2_BFD,NifU,NifU_N
CMS1_k127_2708222_1	1027273.GZ77_25535	2.452e-116	385.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1XHI9@135619|Oceanospirillales	1236|Gammaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	csd	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
CMS1_k127_2708222_4	667014.Thein_1084	2.062e-42	162.0	COG0425@1|root,COG0425@2|Bacteria,2GHSX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	DrsE,TusA
CMS1_k127_2708222_0	1167006.UWK_00694	2.947e-123	426.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
CMS1_k127_2708222_3	502025.Hoch_5736	1.618e-55	209.0	COG1409@1|root,COG1409@2|Bacteria,1PG5U@1224|Proteobacteria,434X0@68525|delta/epsilon subdivisions,2WZ7Y@28221|Deltaproteobacteria,2Z1IU@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS1_k127_272723_2	1195236.CTER_3482	1.317e-103	349.0	COG0464@1|root,COG0464@2|Bacteria,1TQXY@1239|Firmicutes,24AK2@186801|Clostridia,3WI7P@541000|Ruminococcaceae	186801|Clostridia	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS1_k127_272723_6	1034769.KB910518_gene1543	2.294e-23	107.0	2E7AK@1|root,331U1@2|Bacteria,1V9QD@1239|Firmicutes,4HJRQ@91061|Bacilli,26XD8@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
CMS1_k127_272723_1	1195236.CTER_3480	1.748e-130	434.0	COG3497@1|root,COG3497@2|Bacteria,1TNY8@1239|Firmicutes,24BH8@186801|Clostridia,3WHN0@541000|Ruminococcaceae	186801|Clostridia	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
CMS1_k127_272723_0	1195236.CTER_3480	5.255e-147	481.0	COG3497@1|root,COG3497@2|Bacteria,1TNY8@1239|Firmicutes,24BH8@186801|Clostridia,3WHN0@541000|Ruminococcaceae	186801|Clostridia	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
CMS1_k127_272723_3	1195236.CTER_3479	8.401e-58	203.0	2DB76@1|root,2Z7JZ@2|Bacteria,1V5UY@1239|Firmicutes,24IRM@186801|Clostridia,3WJUC@541000|Ruminococcaceae	186801|Clostridia	S	phage tail region protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
CMS1_k127_272723_4	913865.DOT_6091	8.414e-44	162.0	arCOG11412@1|root,31S84@2|Bacteria,1V6H1@1239|Firmicutes,24K0T@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_272723_7	1195236.CTER_3477a	4.758e-16	79.0	arCOG11411@1|root,33A8Q@2|Bacteria,1VM7Z@1239|Firmicutes,24W4Z@186801|Clostridia,3WMQJ@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_272723_5	243231.GSU0979	3.248e-41	156.0	2BEKE@1|root,328BU@2|Bacteria,1RM2J@1224|Proteobacteria,42TNQ@68525|delta/epsilon subdivisions,2WQG6@28221|Deltaproteobacteria,43VX9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
CMS1_k127_2779665_1	517418.Ctha_1299	4.235e-47	179.0	COG1226@1|root,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	yugO	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
CMS1_k127_2779665_2	1307761.L21SP2_1920	1.276e-36	144.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	GGDEF,HATPase_c,HisKA,cNMP_binding
CMS1_k127_2779665_0	1125863.JAFN01000001_gene594	3.975e-62	221.0	COG2738@1|root,COG2738@2|Bacteria,1RDJH@1224|Proteobacteria,42VB4@68525|delta/epsilon subdivisions,2WS37@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
CMS1_k127_2782590_1	760192.Halhy_0567	3.312e-25	116.0	COG3064@1|root,COG5412@1|root,COG3064@2|Bacteria,COG5412@2|Bacteria,4NJXH@976|Bacteroidetes,1IX5R@117747|Sphingobacteriia	976|Bacteroidetes	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Endonuclea_NS_2
CMS1_k127_2782590_0	1157638.KB892170_gene117	6.413e-26	115.0	2E8K4@1|root,332XT@2|Bacteria,2IQ8C@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2782590_2	333138.LQ50_00630	6.94e-14	83.0	COG0438@1|root,COG1543@1|root,COG0438@2|Bacteria,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,4HD14@91061|Bacilli,1ZPVT@1386|Bacillus	91061|Bacilli	M	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS1_k127_2789674_0	398512.JQKC01000002_gene1914	1.999e-261	815.0	COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,3WH6G@541000|Ruminococcaceae	186801|Clostridia	J	glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
CMS1_k127_2789674_1	1158318.ATXC01000001_gene763	2.174e-146	478.0	COG0008@1|root,COG0008@2|Bacteria,2G3SV@200783|Aquificae	200783|Aquificae	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
CMS1_k127_2789674_2	1131269.AQVV01000007_gene1072	4.859e-56	208.0	COG0611@1|root,COG0611@2|Bacteria	2|Bacteria	H	thiamine-phosphate kinase activity	thiL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946,ko:K07123	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c,iSFV_1184.SFV_0382,iYO844.BSU05900	AIRS,AIRS_C
CMS1_k127_2789674_3	639282.DEFDS_0866	9.351e-29	130.0	COG2199@1|root,COG3706@2|Bacteria,2GFTT@200930|Deferribacteres	200930|Deferribacteres	T	SMART GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
CMS1_k127_2791437_2	1121289.JHVL01000007_gene2773	0.0009594	44.0	2FEGS@1|root,346GB@2|Bacteria,1VZ7I@1239|Firmicutes,253R0@186801|Clostridia,36SFF@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2791437_0	1449343.JQLQ01000002_gene1358	2.395e-57	212.0	COG1846@1|root,COG1846@2|Bacteria,1UNNM@1239|Firmicutes,4IUIW@91061|Bacilli	91061|Bacilli	K	Conserved phage C-terminus (Phg_2220_C)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_rep_org_N,Phg_2220_C
CMS1_k127_2794374_2	1123033.ARNF01000021_gene2290	1.664e-16	80.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,1RQ7I@1236|Gammaproteobacteria,3NQSX@468|Moraxellaceae	1236|Gammaproteobacteria	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,rve,rve_3
CMS1_k127_2794374_1	485915.Dret_2536	8.384e-28	115.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,42NJR@68525|delta/epsilon subdivisions,2WKAM@28221|Deltaproteobacteria,2M94G@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
CMS1_k127_2794374_0	1487921.DP68_08460	3.006e-37	164.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,36E5E@31979|Clostridiaceae	186801|Clostridia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
CMS1_k127_2796232_0	552811.Dehly_0590	3.574e-42	162.0	COG0036@1|root,COG0036@2|Bacteria,2G6EU@200795|Chloroflexi,34D4E@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
CMS1_k127_2796232_1	1185876.BN8_03294	1.479e-11	78.0	COG3291@1|root,COG3291@2|Bacteria,4P6HC@976|Bacteroidetes,47YA8@768503|Cytophagia	976|Bacteroidetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD,fn3
CMS1_k127_2803874_0	1304885.AUEY01000007_gene1363	0.0	1417.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
CMS1_k127_2803874_2	484770.UFO1_1362	2.996e-08	63.0	COG1309@1|root,COG1309@2|Bacteria,1V3CI@1239|Firmicutes,4H43E@909932|Negativicutes	909932|Negativicutes	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_2803874_1	1278307.KB906985_gene4364	1.756e-37	146.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS1_k127_2805408_0	243231.GSU3068	3.561e-154	499.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,43U76@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS1_k127_2805408_8	565034.BHWA1_00309	5.629e-56	210.0	COG0707@1|root,COG0707@2|Bacteria,2J5XF@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
CMS1_k127_2805408_3	373903.Hore_09080	6.119e-102	344.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,3WAGK@53433|Halanaerobiales	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
CMS1_k127_2805408_6	1379698.RBG1_1C00001G0394	2.753e-90	314.0	COG0771@1|root,COG0771@2|Bacteria,2NP27@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS1_k127_2805408_2	1307761.L21SP2_1158	2.417e-112	373.0	COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes	203691|Spirochaetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
CMS1_k127_2805408_5	926561.KB900617_gene1679	4.005e-95	328.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,3WAD2@53433|Halanaerobiales	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS1_k127_2805408_1	1408439.JHXW01000018_gene435	1.059e-128	427.0	COG0769@1|root,COG0769@2|Bacteria,37925@32066|Fusobacteria	32066|Fusobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS1_k127_2805408_7	334413.FMG_0611	1.624e-77	270.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,22G9F@1570339|Peptoniphilaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
CMS1_k127_2805408_10	580331.Thit_1491	2.698e-31	127.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,42GA2@68295|Thermoanaerobacterales	186801|Clostridia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
CMS1_k127_2805408_4	945713.IALB_2917	2.807e-99	332.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	ybhF-C	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
CMS1_k127_2805408_9	247490.KSU1_D0848	3.783e-53	192.0	COG0842@1|root,COG0842@2|Bacteria,2IYZA@203682|Planctomycetes	203682|Planctomycetes	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
CMS1_k127_2821973_4	502025.Hoch_6622	4.583e-104	351.0	COG4214@1|root,COG4214@2|Bacteria,1QYSC@1224|Proteobacteria	1224|Proteobacteria	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
CMS1_k127_2821973_1	1499967.BAYZ01000125_gene2596	1.836e-211	668.0	COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria	2|Bacteria	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
CMS1_k127_2821973_2	502025.Hoch_6620	8.707e-151	484.0	COG4213@1|root,COG4213@2|Bacteria,1MX63@1224|Proteobacteria,4306C@68525|delta/epsilon subdivisions,2WVFZ@28221|Deltaproteobacteria,2YU0U@29|Myxococcales	28221|Deltaproteobacteria	G	Periplasmic binding protein domain	xylF	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
CMS1_k127_2821973_7	642492.Clole_0428	1.901e-09	68.0	COG2197@1|root,COG2197@2|Bacteria,1V7ZQ@1239|Firmicutes,25BMW@186801|Clostridia	186801|Clostridia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
CMS1_k127_2821973_6	502025.Hoch_6621	6.224e-29	128.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,42YKP@68525|delta/epsilon subdivisions,2WUQ9@28221|Deltaproteobacteria,2YU8Z@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter	rbsA	-	3.6.3.17	ko:K02056,ko:K05776,ko:K10441,ko:K10545,ko:K10548	ko02010,map02010	M00189,M00212,M00215,M00216,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4,3.A.1.2.5	-	-	ABC_tran
CMS1_k127_2821973_5	525897.Dbac_1479	9.457e-39	152.0	COG1309@1|root,COG1309@2|Bacteria,1MV2V@1224|Proteobacteria,42NW6@68525|delta/epsilon subdivisions,2WPIG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	ko:K13770	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
CMS1_k127_2821973_3	1167006.UWK_03309	1.146e-105	357.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria	1224|Proteobacteria	EGP	Major facilitator superfamily	lplT	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	MFS_1
CMS1_k127_2821973_0	933262.AXAM01000004_gene2415	1.807e-239	767.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,43BJD@68525|delta/epsilon subdivisions,2WIZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,MFS_1,PP-binding
CMS1_k127_2828175_3	867900.Celly_2353	1.732e-15	83.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1HXUN@117743|Flavobacteriia,1FA5X@104264|Cellulophaga	976|Bacteroidetes	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
CMS1_k127_2828175_1	237368.SCABRO_00519	1.091e-89	304.0	COG0284@1|root,COG0284@2|Bacteria,2IXSF@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
CMS1_k127_2828175_2	1168034.FH5T_13475	1.938e-61	216.0	COG2110@1|root,COG2110@2|Bacteria,4NNRH@976|Bacteroidetes,2FMVR@200643|Bacteroidia	976|Bacteroidetes	S	Appr-1'-p processing enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Macro
CMS1_k127_2828175_0	243231.GSU3464	3.96e-211	674.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,42KZC@68525|delta/epsilon subdivisions,2WJ31@28221|Deltaproteobacteria,43TF6@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
CMS1_k127_2837831_1	1158338.JNLJ01000001_gene704	1.245e-53	198.0	COG2890@1|root,COG2890@2|Bacteria,2G42H@200783|Aquificae	200783|Aquificae	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
CMS1_k127_2837831_0	868864.Dester_0270	2.099e-129	423.0	COG0216@1|root,COG0216@2|Bacteria,2G3PA@200783|Aquificae	200783|Aquificae	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS1_k127_2837831_2	1480694.DC28_03230	7.444e-50	182.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_2843594_4	318464.IO99_12495	3.076e-29	123.0	COG0655@1|root,COG0655@2|Bacteria,1V26K@1239|Firmicutes,24IAS@186801|Clostridia,36J7E@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
CMS1_k127_2843594_1	649747.HMPREF0083_00896	7.775e-86	295.0	COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,4H9NQ@91061|Bacilli,26R3P@186822|Paenibacillaceae	91061|Bacilli	S	Twitching motility protein PilT	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	TRAM
CMS1_k127_2843594_3	1329516.JPST01000015_gene745	2.195e-38	149.0	COG1329@1|root,COG1329@2|Bacteria,1V40K@1239|Firmicutes,4HI9J@91061|Bacilli,27BRJ@186824|Thermoactinomycetaceae	91061|Bacilli	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
CMS1_k127_2843594_0	1121405.dsmv_2568	2.865e-130	445.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
CMS1_k127_2843594_2	1120999.JONM01000001_gene1051	3.682e-74	262.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KPBX@206351|Neisseriales	206351|Neisseriales	M	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS1_k127_2857372_4	639282.DEFDS_1412	5.437e-06	53.0	COG0457@1|root,COG0457@2|Bacteria	639282.DEFDS_1412|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2857372_2	1303518.CCALI_00682	2.029e-14	89.0	2909K@1|root,2ZMZ8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2857372_5	102129.Lepto7375DRAFT_1448	7.107e-05	57.0	COG0457@1|root,COG0457@2|Bacteria,1GFPM@1117|Cyanobacteria	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2857372_1	1123274.KB899421_gene1813	1.899e-16	96.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
CMS1_k127_2857372_0	1319815.HMPREF0202_00795	2.558e-53	214.0	COG4878@1|root,COG4878@2|Bacteria,3786A@32066|Fusobacteria	32066|Fusobacteria	S	Uncharacterised protein conserved in bacteria (DUF2194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2194
CMS1_k127_2857372_3	1038869.AXAN01000113_gene2209	2.095e-14	88.0	COG4675@1|root,COG4675@2|Bacteria,1NHDM@1224|Proteobacteria,2W6BN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	tail collar domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2857454_4	883.DvMF_0284	3.151e-40	154.0	COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,42T5Y@68525|delta/epsilon subdivisions,2WNT6@28221|Deltaproteobacteria,2MAZR@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS1_k127_2857454_5	1340434.AXVA01000022_gene3950	9.019e-30	133.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,4HAPA@91061|Bacilli,1ZBBG@1386|Bacillus	91061|Bacilli	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS1_k127_2857454_7	1125699.HMPREF9194_00130	2.274e-08	59.0	2AN0D@1|root,31CXM@2|Bacteria,2J95J@203691|Spirochaetes	203691|Spirochaetes	S	Anti-sigma-28 factor, FlgM	-	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
CMS1_k127_2857454_3	1123274.KB899407_gene189	5.197e-60	214.0	COG0313@1|root,COG0313@2|Bacteria,2J5DW@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
CMS1_k127_2857454_1	573413.Spirs_0361	5.9e-103	343.0	COG1131@1|root,COG1131@2|Bacteria,2J5JM@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_2857454_2	1047013.AQSP01000113_gene744	5.29e-63	225.0	COG1277@1|root,COG1277@2|Bacteria,2NPGK@2323|unclassified Bacteria	2|Bacteria	S	ABC-2 family transporter protein	gldF	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
CMS1_k127_2857454_0	1125725.HMPREF1325_1364	8.284e-131	441.0	COG3225@1|root,COG3225@2|Bacteria,2J5I3@203691|Spirochaetes	203691|Spirochaetes	N	PFAM ABC-type uncharacterised transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
CMS1_k127_2857454_6	1265505.ATUG01000001_gene3528	1.681e-11	75.0	28V7D@1|root,2ZHAI@2|Bacteria,1RA29@1224|Proteobacteria,42R9H@68525|delta/epsilon subdivisions,2WN1D@28221|Deltaproteobacteria,2MJN2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
CMS1_k127_2858156_0	580327.Tthe_1651	2.307e-32	141.0	COG0501@1|root,COG0501@2|Bacteria,1TRQE@1239|Firmicutes,24E6C@186801|Clostridia,42FHZ@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM Peptidase M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
CMS1_k127_2858156_1	768671.ThimaDRAFT_3647	4.544e-32	134.0	COG5522@1|root,COG5522@2|Bacteria,1MYKS@1224|Proteobacteria,1SEKW@1236|Gammaproteobacteria,1X04I@135613|Chromatiales	135613|Chromatiales	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
CMS1_k127_2873896_0	521045.Kole_0461	1.074e-161	544.0	COG0366@1|root,COG4945@1|root,COG0366@2|Bacteria,COG4945@2|Bacteria,2GCP8@200918|Thermotogae	200918|Thermotogae	G	PFAM alpha amylase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Glucodextran_C
CMS1_k127_2873896_1	1226325.HMPREF1548_06748	2.373e-08	60.0	COG1396@1|root,COG1396@2|Bacteria,1VEU8@1239|Firmicutes,24QN0@186801|Clostridia,36N7U@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
CMS1_k127_2877853_0	1379281.AVAG01000030_gene66	1.271e-103	362.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PGC@68525|delta/epsilon subdivisions,2WKHK@28221|Deltaproteobacteria,2MHHP@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	FHA,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3
CMS1_k127_2877853_2	1322246.BN4_10665	5.786e-24	105.0	COG1639@1|root,COG2197@1|root,COG1639@2|Bacteria,COG2197@2|Bacteria,1R6YN@1224|Proteobacteria,42Q4G@68525|delta/epsilon subdivisions,2WJM9@28221|Deltaproteobacteria,2M947@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Metal-dependent hydrolase HDOD	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
CMS1_k127_2877853_1	237368.SCABRO_02341	4.618e-92	315.0	COG3437@1|root,COG3437@2|Bacteria,2IZ8V@203682|Planctomycetes	203682|Planctomycetes	T	cheY-homologous receiver domain	-	-	-	ko:K19623	-	-	-	-	ko00000,ko02022	-	-	-	HD_5,Response_reg
CMS1_k127_28863_0	889378.Spiaf_1687	1.628e-06	61.0	COG2208@1|root,COG2208@2|Bacteria,2J5MN@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,SpoIIE
CMS1_k127_2893599_1	439235.Dalk_1485	1.637e-21	107.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core	-	-	-	-	-	-	-	-	-	-	-	-	AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
CMS1_k127_2893599_0	43989.cce_3860	1.416e-41	162.0	2CM5E@1|root,332ZW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2893599_4	1125701.HMPREF1221_00423	3.56e-10	65.0	COG1487@1|root,COG1487@2|Bacteria,2JB04@203691|Spirochaetes	203691|Spirochaetes	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS1_k127_2893599_3	324925.Ppha_1706	1.703e-12	69.0	2DRB5@1|root,33B20@2|Bacteria	2|Bacteria	S	addiction module component	-	-	-	-	-	-	-	-	-	-	-	-	Unstab_antitox
CMS1_k127_2893599_2	153948.NAL212_2556	3.598e-15	78.0	COG3668@1|root,COG3668@2|Bacteria,1N73M@1224|Proteobacteria,2VXUM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
CMS1_k127_2893599_5	768671.ThimaDRAFT_1331	6.789e-07	51.0	COG3668@1|root,COG3668@2|Bacteria,1NHQV@1224|Proteobacteria,1SI98@1236|Gammaproteobacteria,1WZSW@135613|Chromatiales	135613|Chromatiales	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2897176_0	720554.Clocl_0575	5.018e-96	330.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,3WGY3@541000|Ruminococcaceae	186801|Clostridia	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
CMS1_k127_2897176_1	1001530.BACE01000011_gene2389	1.249e-72	257.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN2K@1236|Gammaproteobacteria,1XU47@135623|Vibrionales	135623|Vibrionales	K	Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression	purR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	ko:K03604	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_2906912_2	1121434.AULY01000011_gene1673	2.814e-45	171.0	COG1028@1|root,COG1028@2|Bacteria,1N67D@1224|Proteobacteria,42UG0@68525|delta/epsilon subdivisions,2WQ22@28221|Deltaproteobacteria,2MBTA@213115|Desulfovibrionales	28221|Deltaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
CMS1_k127_2906912_4	207559.Dde_2659	1.242e-21	98.0	COG0236@1|root,COG0236@2|Bacteria,1NCHG@1224|Proteobacteria,42VNN@68525|delta/epsilon subdivisions,2WRE3@28221|Deltaproteobacteria,2MDHA@213115|Desulfovibrionales	28221|Deltaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS1_k127_2906912_3	335543.Sfum_3715	4.967e-37	147.0	COG0778@1|root,COG0778@2|Bacteria,1Q8UE@1224|Proteobacteria,42ZWU@68525|delta/epsilon subdivisions,2WVAP@28221|Deltaproteobacteria,2MRR1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS1_k127_2906912_0	1121434.AULY01000011_gene1671	3.298e-115	383.0	COG0304@1|root,COG0304@2|Bacteria,1R6X1@1224|Proteobacteria,42QEN@68525|delta/epsilon subdivisions,2WM1T@28221|Deltaproteobacteria,2M956@213115|Desulfovibrionales	28221|Deltaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
CMS1_k127_2906912_1	56780.SYN_02568	1.478e-113	377.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2MQRQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Beta-eliminating lyase	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_2906912_5	589924.Ferp_2436	6.943e-07	58.0	COG0500@1|root,arCOG04347@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Ubie_methyltran
CMS1_k127_2917024_1	1122226.AUHX01000005_gene2529	2.464e-29	123.0	COG3867@1|root,COG3867@2|Bacteria,4NI3G@976|Bacteroidetes,1I0YN@117743|Flavobacteriia	976|Bacteroidetes	G	Arabinogalactan endo-beta-1,4-galactanase	-	-	3.2.1.89	ko:K01224	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_53
CMS1_k127_2917024_0	1304885.AUEY01000012_gene1779	4.177e-231	725.0	COG1028@1|root,COG1028@2|Bacteria,1R4BM@1224|Proteobacteria,42PS2@68525|delta/epsilon subdivisions,2WJJK@28221|Deltaproteobacteria,2MJ0I@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
CMS1_k127_2917060_0	509191.AEDB02000003_gene1043	2.288e-117	400.0	COG2199@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5002@2|Bacteria,1UVSG@1239|Firmicutes,24B7R@186801|Clostridia	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_2921515_1	945713.IALB_0806	1.916e-61	216.0	COG0231@1|root,COG0231@2|Bacteria	2|Bacteria	J	translation elongation factor activity	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
CMS1_k127_2921515_0	941824.TCEL_00267	6.77e-88	302.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,36E1G@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the peptidase M24B family	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
CMS1_k127_2925569_6	335543.Sfum_1261	3.094e-59	216.0	COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,42P30@68525|delta/epsilon subdivisions,2WIPV@28221|Deltaproteobacteria,2MQE9@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	radical SAM domain protein	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS1_k127_2925569_7	318464.IO99_09270	1.479e-54	207.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,36F3D@31979|Clostridiaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
CMS1_k127_2925569_4	1121289.JHVL01000015_gene2707	5.387e-61	226.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,36F3D@31979|Clostridiaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
CMS1_k127_2925569_10	1209989.TepiRe1_0101	5.243e-05	51.0	COG1396@1|root,COG3620@1|root,COG1396@2|Bacteria,COG3620@2|Bacteria,1V0UH@1239|Firmicutes,24F2M@186801|Clostridia,42FSQ@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_2925569_8	1289135.A966_10482	3.305e-24	113.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K08642	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M23
CMS1_k127_2925569_2	621372.ACIH01000240_gene1448	1.486e-99	353.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H9SA@91061|Bacilli,26SN1@186822|Paenibacillaceae	91061|Bacilli	M	Carboxypeptidase	pbpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.4.1.129,3.4.16.4	ko:K21464	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
CMS1_k127_2925569_3	572544.Ilyop_0795	2.685e-76	267.0	COG0820@1|root,COG0820@2|Bacteria,37847@32066|Fusobacteria	32066|Fusobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
CMS1_k127_2925569_0	1089553.Tph_c10090	4.38e-159	512.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,42EXA@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
CMS1_k127_2925569_1	1211817.CCAT010000086_gene2354	1.725e-126	412.0	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,36DRX@31979|Clostridiaceae	186801|Clostridia	C	phosphate acetyltransferase	pta	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
CMS1_k127_2925569_9	272123.Anacy_0626	5.952e-08	59.0	COG5513@1|root,COG5513@2|Bacteria	2|Bacteria	G	serine-type aminopeptidase activity	-	-	-	ko:K02030,ko:K14475	ko05143,map05143	M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3	-	-	Inhibitor_I42
CMS1_k127_2925569_5	272123.Anacy_0627	8.754e-61	225.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.15	ko:K01365,ko:K14475	ko04140,ko04142,ko04145,ko04210,ko04612,ko05143,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05143,map05205,map05323,map05418	-	-	-	ko00000,ko00001,ko00537,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I42,Peptidase_C1
CMS1_k127_29266_8	525897.Dbac_0052	3.296e-65	250.0	COG0834@1|root,COG4191@1|root,COG5002@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WKCD@28221|Deltaproteobacteria,2M8VY@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,SBP_bac_3,dCache_1
CMS1_k127_29266_12	1121403.AUCV01000002_gene495	2.321e-25	123.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X8D5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
CMS1_k127_29266_6	696747.NIES39_C05180	1.121e-71	266.0	COG1520@1|root,COG2931@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,1GQUQ@1117|Cyanobacteria,1HBB3@1150|Oscillatoriales	1117|Cyanobacteria	G	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind
CMS1_k127_29266_15	401053.AciPR4_1223	1.929e-10	76.0	COG4932@1|root,COG5276@1|root,COG4932@2|Bacteria,COG5276@2|Bacteria,3Y8ZJ@57723|Acidobacteria	57723|Acidobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494
CMS1_k127_29266_14	331113.SNE_A21990	3.782e-14	84.0	COG0027@1|root,COG0027@2|Bacteria,2JG5J@204428|Chlamydiae	204428|Chlamydiae	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_29266_4	679937.Bcop_1047	1.89e-85	293.0	COG0324@1|root,COG0324@2|Bacteria,4NFJY@976|Bacteroidetes,2FM0H@200643|Bacteroidia,4AKBM@815|Bacteroidaceae	976|Bacteroidetes	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA2	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
CMS1_k127_29266_16	7217.FBpp0117173	6.553e-06	55.0	COG3914@1|root,KOG4626@2759|Eukaryota,38EM5@33154|Opisthokonta,3BC3N@33208|Metazoa,3CWN6@33213|Bilateria,41VJW@6656|Arthropoda,3SGP8@50557|Insecta,4505I@7147|Diptera,45PYV@7214|Drosophilidae	33208|Metazoa	GOT	Glycosyl transferase family 41	OGT	GO:0000003,GO:0000123,GO:0000785,GO:0000791,GO:0001678,GO:0001932,GO:0001933,GO:0001934,GO:0002119,GO:0002164,GO:0002237,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005488,GO:0005515,GO:0005543,GO:0005547,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0006040,GO:0006041,GO:0006047,GO:0006048,GO:0006073,GO:0006091,GO:0006109,GO:0006110,GO:0006111,GO:0006112,GO:0006139,GO:0006140,GO:0006325,GO:0006355,GO:0006357,GO:0006464,GO:0006470,GO:0006473,GO:0006475,GO:0006479,GO:0006486,GO:0006493,GO:0006508,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007444,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0007626,GO:0008080,GO:0008134,GO:0008150,GO:0008152,GO:0008194,GO:0008213,GO:0008219,GO:0008289,GO:0008361,GO:0008375,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009719,GO:0009725,GO:0009743,GO:0009746,GO:0009749,GO:0009791,GO:0009888,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010563,GO:0010604,GO:0010605,GO:0010628,GO:0010638,GO:0010646,GO:0010675,GO:0010799,GO:0010801,GO:0010876,GO:0010906,GO:0010941,GO:0012501,GO:0012505,GO:0015980,GO:0016020,GO:0016043,GO:0016262,GO:0016311,GO:0016407,GO:0016410,GO:0016485,GO:0016569,GO:0016570,GO:0016571,GO:0016573,GO:0016579,GO:0016740,GO:0016746,GO:0016747,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0018022,GO:0018023,GO:0018130,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019725,GO:0019904,GO:0019915,GO:0022607,GO:0023051,GO:0023052,GO:0030141,GO:0030162,GO:0030246,GO:0030808,GO:0030811,GO:0030900,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031248,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0031396,GO:0031397,GO:0031399,GO:0031400,GO:0031401,GO:0031410,GO:0031667,GO:0031974,GO:0031981,GO:0031982,GO:0032259,GO:0032268,GO:0032269,GO:0032270,GO:0032386,GO:0032387,GO:0032434,GO:0032435,GO:0032496,GO:0032501,GO:0032502,GO:0032535,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032922,GO:0032991,GO:0033036,GO:0033043,GO:0033044,GO:0033135,GO:0033137,GO:0033157,GO:0033218,GO:0033500,GO:0033993,GO:0034284,GO:0034641,GO:0034645,GO:0034654,GO:0034968,GO:0035020,GO:0035091,GO:0035220,GO:0035295,GO:0035556,GO:0036094,GO:0036211,GO:0036477,GO:0040024,GO:0042176,GO:0042177,GO:0042221,GO:0042277,GO:0042325,GO:0042326,GO:0042327,GO:0042578,GO:0042588,GO:0042592,GO:0042593,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043255,GO:0043412,GO:0043413,GO:0043414,GO:0043434,GO:0043467,GO:0043470,GO:0043543,GO:0043933,GO:0043967,GO:0043981,GO:0043982,GO:0043984,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045475,GO:0045793,GO:0045861,GO:0045862,GO:0045893,GO:0045935,GO:0045936,GO:0045937,GO:0045944,GO:0046349,GO:0046483,GO:0046578,GO:0046626,GO:0048015,GO:0048017,GO:0048029,GO:0048311,GO:0048312,GO:0048471,GO:0048511,GO:0048512,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051056,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051193,GO:0051196,GO:0051223,GO:0051224,GO:0051235,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051276,GO:0051291,GO:0051568,GO:0051604,GO:0051640,GO:0051641,GO:0051646,GO:0051704,GO:0051707,GO:0051716,GO:0055082,GO:0055086,GO:0055114,GO:0060255,GO:0060322,GO:0060341,GO:0060429,GO:0060548,GO:0061085,GO:0061087,GO:0061136,GO:0062012,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070085,GO:0070201,GO:0070206,GO:0070207,GO:0070208,GO:0070646,GO:0070647,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071310,GO:0071322,GO:0071326,GO:0071331,GO:0071333,GO:0071375,GO:0071396,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0080182,GO:0090066,GO:0090087,GO:0090313,GO:0090315,GO:0090317,GO:0097237,GO:0097363,GO:0097458,GO:0097708,GO:0099503,GO:0120025,GO:0140096,GO:1900037,GO:1900038,GO:1900076,GO:1900180,GO:1900182,GO:1900371,GO:1900542,GO:1901071,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901799,GO:1901981,GO:1902275,GO:1902493,GO:1902494,GO:1902531,GO:1902680,GO:1903050,GO:1903051,GO:1903320,GO:1903321,GO:1903362,GO:1903363,GO:1903426,GO:1903428,GO:1903506,GO:1903508,GO:1903533,GO:1903578,GO:1903827,GO:1903828,GO:1903829,GO:1904950,GO:1905269,GO:1905475,GO:1905476,GO:1990234,GO:2000058,GO:2000059,GO:2000112,GO:2000377,GO:2000379,GO:2001141,GO:2001169,GO:2001252	2.4.1.255	ko:K09667	ko00514,ko04931,map00514,map04931	-	R09304,R09676	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003,ko03036	-	GT41	-	Glyco_transf_41,TPR_1,TPR_11,TPR_2,TPR_8
CMS1_k127_29266_2	398511.BpOF4_00045	4.041e-93	313.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,4H9N5@91061|Bacilli,1ZAYU@1386|Bacillus	91061|Bacilli	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
CMS1_k127_29266_5	626939.HMPREF9443_00700	6.398e-72	252.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4H35I@909932|Negativicutes	909932|Negativicutes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
CMS1_k127_29266_3	648996.Theam_0089	3.682e-90	302.0	COG0528@1|root,COG0528@2|Bacteria,2G3IX@200783|Aquificae	200783|Aquificae	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
CMS1_k127_29266_9	1449126.JQKL01000001_gene1362	6.033e-64	224.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,2690Q@186813|unclassified Clostridiales	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
CMS1_k127_29266_7	865861.AZSU01000003_gene1720	1.325e-65	231.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,36DDR@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
CMS1_k127_29266_11	945713.IALB_0622	4.148e-35	145.0	COG4589@1|root,COG4589@2|Bacteria	2|Bacteria	S	phosphatidate cytidylyltransferase activity	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CMS1_k127_29266_1	1169144.KB910939_gene2854	1.87e-111	372.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,4HBAV@91061|Bacilli,1ZMCV@1386|Bacillus	91061|Bacilli	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
CMS1_k127_29266_10	1289135.A966_02961	9.558e-59	223.0	COG0750@1|root,COG0750@2|Bacteria,2J616@203691|Spirochaetes	203691|Spirochaetes	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
CMS1_k127_29266_0	1321778.HMPREF1982_02066	4.388e-114	379.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,268E9@186813|unclassified Clostridiales	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
CMS1_k127_2950337_4	926561.KB900617_gene1358	9.024e-14	83.0	COG0366@1|root,COG1974@1|root,COG0366@2|Bacteria,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,HTH_3,PKD,Peptidase_S24,SLH
CMS1_k127_2950337_2	1480694.DC28_10860	9.509e-85	287.0	COG0037@1|root,COG0037@2|Bacteria,2J61I@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the TtcA family	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
CMS1_k127_2950337_0	472759.Nhal_0103	6.497e-146	475.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1WX09@135613|Chromatiales	135613|Chromatiales	P	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG
CMS1_k127_2950337_3	1121286.AUMT01000011_gene2389	3.683e-80	271.0	COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,1HYH3@117743|Flavobacteriia,3ZPQA@59732|Chryseobacterium	976|Bacteroidetes	L	DNA-3-methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
CMS1_k127_2950337_1	1313421.JHBV01000042_gene3389	2.241e-111	371.0	COG2304@1|root,COG2304@2|Bacteria,4NEGD@976|Bacteroidetes,1IVER@117747|Sphingobacteriia	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS1_k127_2950337_5	1499967.BAYZ01000173_gene5813	3.292e-05	49.0	COG2304@1|root,COG2304@2|Bacteria,2NPZM@2323|unclassified Bacteria	2|Bacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	FecR,VIT,VWA,VWA_3
CMS1_k127_295664_8	8469.XP_007064054.1	5.273e-06	59.0	COG0457@1|root,KOG4648@2759|Eukaryota,38GIQ@33154|Opisthokonta,3BEKH@33208|Metazoa,3CVSY@33213|Bilateria,4812P@7711|Chordata,48XR5@7742|Vertebrata,4CEBE@8459|Testudines	33208|Metazoa	S	RNA polymerase II-associated protein 3	RPAP3	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0010941,GO:0030544,GO:0031072,GO:0032991,GO:0042752,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043523,GO:0043524,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050795,GO:0051879,GO:0060548,GO:0065007,GO:0097255,GO:1901214,GO:1901215,GO:1904059,GO:2000671,GO:2000672	-	ko:K00237	ko00020,ko00190,ko01100,ko01110,ko01120,ko01130,ko01200,ko04714,ko04932,ko05010,ko05012,ko05016,map00020,map00190,map01100,map01110,map01120,map01130,map01200,map04714,map04932,map05010,map05012,map05016	M00009,M00011,M00148	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	RPAP3_C,TPR_1,TPR_11,TPR_2,TPR_7,TPR_8
CMS1_k127_295664_4	880073.Calab_0900	3.66e-50	184.0	COG2078@1|root,COG2078@2|Bacteria,2NPQ0@2323|unclassified Bacteria	2|Bacteria	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
CMS1_k127_295664_2	909663.KI867150_gene603	1.595e-66	236.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,2MQCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
CMS1_k127_295664_5	1128398.Curi_c16870	2.747e-43	166.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,26874@186813|unclassified Clostridiales	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CMS1_k127_295664_3	762966.HMPREF9439_02275	2.178e-51	187.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,4PQ6S@995019|Sutterellaceae	28216|Betaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
CMS1_k127_295664_1	938288.HG326224_gene1426	4.542e-97	341.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,26885@186813|unclassified Clostridiales	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
CMS1_k127_295664_7	744872.Spica_2050	7.69e-22	100.0	COG0629@1|root,COG0629@2|Bacteria,2J86A@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS1_k127_295664_0	572544.Ilyop_0154	1.206e-204	647.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	bicA	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,STAS_2,Sulfate_transp
CMS1_k127_295664_6	1408433.JHXV01000008_gene88	1.109e-35	150.0	2EBC4@1|root,335CV@2|Bacteria,4P1X4@976|Bacteroidetes	976|Bacteroidetes	G	Glycosyl hydrolase family 53	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_53
CMS1_k127_2957704_3	929703.KE386492_gene4325	9.647e-57	203.0	COG1896@1|root,COG1896@2|Bacteria,4NGW7@976|Bacteroidetes,47PAJ@768503|Cytophagia	976|Bacteroidetes	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
CMS1_k127_2957704_5	1437425.CSEC_1133	9.444e-33	131.0	COG0636@1|root,COG0636@2|Bacteria,2JG1V@204428|Chlamydiae	204428|Chlamydiae	C	ATP synthase, subunit	atpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
CMS1_k127_2957704_2	1437425.CSEC_1134	5.867e-73	269.0	COG1269@1|root,COG1269@2|Bacteria,2JFCG@204428|Chlamydiae	204428|Chlamydiae	C	ATP synthase, subunit I	atpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
CMS1_k127_2957704_4	765952.PUV_23290	5.275e-45	170.0	COG1394@1|root,COG1394@2|Bacteria,2JG3P@204428|Chlamydiae	204428|Chlamydiae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
CMS1_k127_2957704_1	264201.pc1679	5.297e-188	596.0	COG1156@1|root,COG1156@2|Bacteria,2JFMM@204428|Chlamydiae	204428|Chlamydiae	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS1_k127_2957704_0	1444712.BN1013_00828	5.573e-218	691.0	COG1155@1|root,COG1155@2|Bacteria,2JFIJ@204428|Chlamydiae	204428|Chlamydiae	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
CMS1_k127_2957704_6	869213.JCM21142_93432	2.978e-05	52.0	COG1527@1|root,COG1527@2|Bacteria,4NQJX@976|Bacteroidetes	976|Bacteroidetes	C	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DUF2764
CMS1_k127_2966389_0	402777.KB235904_gene2692	3.497e-239	756.0	COG0366@1|root,COG0366@2|Bacteria,1G0NX@1117|Cyanobacteria,1H7KE@1150|Oscillatoriales	1117|Cyanobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_20
CMS1_k127_2966389_1	1232449.BAHV02000001_gene492	6.752e-88	307.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,267NB@186813|unclassified Clostridiales	186801|Clostridia	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
CMS1_k127_2966389_3	1280692.AUJL01000026_gene2183	1.191e-42	164.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,36F11@31979|Clostridiaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
CMS1_k127_2966389_2	443143.GM18_4521	2.262e-56	217.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
CMS1_k127_2966389_4	944564.HMPREF9200_0812	2.298e-22	99.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes	1239|Firmicutes	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
CMS1_k127_2966389_6	411465.PEPMIC_00560	1.619e-06	54.0	COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,25MZA@186801|Clostridia,22HWK@1570339|Peptoniphilaceae	186801|Clostridia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
CMS1_k127_2966389_5	319795.Dgeo_1568	1.62e-13	71.0	COG0230@1|root,COG0230@2|Bacteria	2|Bacteria	J	Ribosomal protein L34	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
CMS1_k127_2969335_3	1304874.JAFY01000007_gene1743	4.404e-06	50.0	COG0785@1|root,COG0785@2|Bacteria,3TBEJ@508458|Synergistetes	508458|Synergistetes	O	PFAM Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
CMS1_k127_2969335_2	1499967.BAYZ01000050_gene2875	3.887e-22	102.0	2DPAK@1|root,33193@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2969335_1	903818.KI912268_gene1295	2.146e-33	132.0	COG4273@1|root,COG4273@2|Bacteria	2|Bacteria	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
CMS1_k127_2969335_0	1121403.AUCV01000022_gene3495	8.798e-142	473.0	COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,42NYN@68525|delta/epsilon subdivisions,2WJFE@28221|Deltaproteobacteria,2MHZZ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
CMS1_k127_297127_3	387093.SUN_0343	4.255e-56	207.0	COG0451@1|root,COG0451@2|Bacteria,1MVPZ@1224|Proteobacteria,42MVR@68525|delta/epsilon subdivisions,2YNC0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	NAD dependent epimerase dehydratase family	-	-	1.1.1.135	ko:K22252	ko00051,ko00520,map00051,map00520	-	R03396,R03398	RC00182	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS1_k127_297127_1	387092.NIS_1386	5.514e-149	478.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,42KZY@68525|delta/epsilon subdivisions,2YMQF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
CMS1_k127_297127_0	1150621.SMUL_2476	3.039e-222	695.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MA3@68525|delta/epsilon subdivisions,2YMI4@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
CMS1_k127_297127_4	394503.Ccel_0350	2.062e-23	104.0	COG2246@1|root,COG2246@2|Bacteria,1VFGI@1239|Firmicutes,24RJP@186801|Clostridia,36PMT@31979|Clostridiaceae	186801|Clostridia	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
CMS1_k127_297127_2	1121333.JMLH01000028_gene1131	3.884e-70	248.0	COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,3VP1J@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_297127_5	713586.KB900536_gene886	0.0006429	45.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,1RNJD@1236|Gammaproteobacteria,1WX9A@135613|Chromatiales	135613|Chromatiales	GM	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CMS1_k127_2972375_2	373994.Riv7116_5003	0.0008963	51.0	COG4995@1|root,COG4995@2|Bacteria,1G1G5@1117|Cyanobacteria,1HMYM@1161|Nostocales	1117|Cyanobacteria	S	COGs COG4995 conserved	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
CMS1_k127_2972375_1	443143.GM18_0223	8.943e-21	105.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
CMS1_k127_2972375_0	1480694.DC28_10570	7.585e-28	127.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
CMS1_k127_2973230_0	926561.KB900617_gene1912	5.458e-48	189.0	COG0296@1|root,COG4580@1|root,COG0296@2|Bacteria,COG4580@2|Bacteria	2|Bacteria	M	maltodextrin transmembrane transporter activity	lamB	-	3.2.1.133,3.2.1.135,3.2.1.54	ko:K01208,ko:K02024,ko:K16077	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R11262	-	ko00000,ko00001,ko01000,ko02000	1.B.3.1.1,1.B.3.1.2	GH13	-	AMPK1_CBM,Alpha-amylase,Glucodextran_C,LamB
CMS1_k127_2973230_2	1380384.JADN01000007_gene1724	1.417e-11	74.0	COG0664@1|root,COG0664@2|Bacteria,4NM5E@976|Bacteroidetes,1I1AQ@117743|Flavobacteriia	976|Bacteroidetes	K	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_2973230_1	880073.Calab_0919	1.649e-15	86.0	COG2182@1|root,COG2182@2|Bacteria	2|Bacteria	G	maltose binding	-	-	-	ko:K15770,ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1,Cu_amine_oxidN1,SBP_bac_8
CMS1_k127_297348_0	1121918.ARWE01000001_gene2035	2.209e-76	274.0	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,43TNQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
CMS1_k127_2978011_2	1243664.CAVL020000019_gene3526	8.565e-12	72.0	COG1595@1|root,COG1595@2|Bacteria,1VCGI@1239|Firmicutes,4HKEY@91061|Bacilli,1ZGIC@1386|Bacillus	91061|Bacilli	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_2978011_0	1442598.JABW01000005_gene611	3.157e-32	130.0	2DMP9@1|root,32SV1@2|Bacteria,1N17Y@1224|Proteobacteria,42TQF@68525|delta/epsilon subdivisions,2YQ0W@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Protein of unknown function (DUF3015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3015
CMS1_k127_2978011_1	1304885.AUEY01000106_gene3424	1.31e-14	78.0	28J7E@1|root,2Z92U@2|Bacteria,1NAE1@1224|Proteobacteria,42P08@68525|delta/epsilon subdivisions,2WJXV@28221|Deltaproteobacteria,2MI0F@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
CMS1_k127_2979052_1	406327.Mevan_1600	1.373e-32	129.0	COG0322@1|root,arCOG04753@2157|Archaea,2XTH1@28890|Euryarchaeota,23REH@183939|Methanococci	183939|Methanococci	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR,UvrC_HhH_N
CMS1_k127_2979052_2	1406840.Q763_08515	4.799e-05	55.0	COG0457@1|root,COG0457@2|Bacteria,4NF5V@976|Bacteroidetes,1HYKU@117743|Flavobacteriia,2NU4E@237|Flavobacterium	976|Bacteroidetes	T	BatE protein	batE	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2
CMS1_k127_2979052_0	323259.Mhun_2689	2.262e-36	145.0	COG0642@1|root,arCOG02358@2157|Archaea,2XVY8@28890|Euryarchaeota,2N9XQ@224756|Methanomicrobia	224756|Methanomicrobia	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HATPase_c,HisKA,PAS_4
CMS1_k127_2980840_0	316274.Haur_1785	3.777e-72	256.0	292QY@1|root,2ZQ8Q@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2980840_1	316274.Haur_1786	9.418e-40	153.0	2E8EM@1|root,332T0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2980840_2	111781.Lepto7376_0638	2.035e-12	70.0	COG2815@1|root,COG2815@2|Bacteria	2|Bacteria	G	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_2982527_0	56780.SYN_00141	7.781e-95	324.0	COG0235@1|root,COG0235@2|Bacteria,1N84G@1224|Proteobacteria,42RVW@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	PFAM class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
CMS1_k127_2982527_1	1265505.ATUG01000003_gene713	4.2e-46	177.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
CMS1_k127_298482_3	439235.Dalk_0959	2.799e-14	82.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2MHRG@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS1_k127_298482_5	759914.BP951000_1382	6.007e-07	57.0	COG2172@1|root,COG2172@2|Bacteria,2JBA4@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
CMS1_k127_298482_0	1121335.Clst_1985	2.733e-219	692.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,3WGBI@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
CMS1_k127_298482_1	671143.DAMO_1501	1.169e-174	559.0	COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iSB619.SA_RS05225	GATase_6,GATase_7,Pribosyltran
CMS1_k127_298482_2	204669.Acid345_3963	4.688e-32	143.0	COG1961@1|root,COG1961@2|Bacteria,3Y3F6@57723|Acidobacteria,2JKJ1@204432|Acidobacteriia	204432|Acidobacteriia	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase
CMS1_k127_298482_4	795359.TOPB45_0703	2.223e-09	60.0	COG1328@1|root,COG1328@2|Bacteria,2GI4Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Anaerobic ribonucleoside-triphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	NRDD
CMS1_k127_2992309_0	469617.FUAG_02175	1.805e-37	144.0	COG0420@1|root,COG0420@2|Bacteria,378KS@32066|Fusobacteria	32066|Fusobacteria	L	Calcineurin-like phosphoesterase superfamily domain	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
CMS1_k127_2992309_1	1121918.ARWE01000001_gene2835	4.94e-31	133.0	COG0697@1|root,COG0697@2|Bacteria,1MX1Y@1224|Proteobacteria,42NTW@68525|delta/epsilon subdivisions,2WMEN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS1_k127_2992309_2	5722.XP_001319033.1	3.237e-18	93.0	COG0666@1|root,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
CMS1_k127_2993687_0	1304284.L21TH_1879	5.542e-70	244.0	COG4555@1|root,COG4555@2|Bacteria,1UHYH@1239|Firmicutes,25E73@186801|Clostridia,36EUM@31979|Clostridiaceae	186801|Clostridia	CP	AAA domain, putative AbiEii toxin, Type IV TA system	natA	-	3.6.3.7	ko:K09697	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.115	-	-	ABC_tran
CMS1_k127_2993687_1	86416.Clopa_0175	9.286e-40	162.0	COG1668@1|root,COG1668@2|Bacteria,1TQNC@1239|Firmicutes,2489Z@186801|Clostridia,36GGI@31979|Clostridiaceae	186801|Clostridia	CP	ABC-2 family transporter protein	natB	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,ABC2_membrane_3,Abi
CMS1_k127_2996587_0	86416.Clopa_2664	5.461e-95	327.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,36DJV@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CMS1_k127_3005018_1	1347392.CCEZ01000043_gene115	1.014e-61	226.0	COG0614@1|root,COG0614@2|Bacteria,1TQ11@1239|Firmicutes,2482R@186801|Clostridia,36E5P@31979|Clostridiaceae	186801|Clostridia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS1_k127_3005018_0	694427.Palpr_0499	1.631e-69	261.0	COG1629@1|root,COG4771@2|Bacteria,4NFQD@976|Bacteroidetes,2G3H3@200643|Bacteroidia	976|Bacteroidetes	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
CMS1_k127_3013368_0	903818.KI912268_gene1360	4.816e-68	257.0	COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,3Y2IQ@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS1_k127_3013947_0	927677.ALVU02000001_gene4525	1.796e-71	261.0	COG0642@1|root,COG0784@1|root,COG3614@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3614@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,DUF4118,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
CMS1_k127_3016798_7	443143.GM18_2527	1.781e-29	136.0	COG0591@1|root,COG2203@1|root,COG2208@1|root,COG0591@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1QTSW@1224|Proteobacteria,43AQ6@68525|delta/epsilon subdivisions,2X63Z@28221|Deltaproteobacteria,43W3H@69541|Desulfuromonadales	28221|Deltaproteobacteria	EKT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SpoIIE
CMS1_k127_3016798_4	1192034.CAP_1505	2.713e-42	177.0	COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2Z380@29|Myxococcales	28221|Deltaproteobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,Cache_3-Cache_2,HAMP,HATPase_c_2,SpoIIE,dCache_1,dCache_2
CMS1_k127_3016798_9	237368.SCABRO_01928	1.327e-15	79.0	2ENS9@1|root,33GDF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3016798_3	290315.Clim_0095	2.545e-48	174.0	COG0347@1|root,COG0347@2|Bacteria,1FF5F@1090|Chlorobi	1090|Chlorobi	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
CMS1_k127_3016798_0	96561.Dole_0566	1.359e-153	496.0	COG0004@1|root,COG0004@2|Bacteria,1R50W@1224|Proteobacteria,42PKR@68525|delta/epsilon subdivisions,2WM8P@28221|Deltaproteobacteria,2MII5@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CMS1_k127_3016798_2	1536775.H70737_09475	5.323e-70	272.0	COG4733@1|root,COG5184@1|root,COG5492@1|root,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_2,Big_3_2,Cadherin-like,DUF4347,Flg_new,He_PIG,HemolysinCabind,Laminin_G_3,SLH
CMS1_k127_3016798_1	1089548.KI783301_gene862	8.955e-146	476.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,4HDD6@91061|Bacilli,3WFFM@539002|Bacillales incertae sedis	91061|Bacilli	Q	Multicopper oxidase	mco	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
CMS1_k127_3016798_5	1216932.CM240_3093	1.358e-36	142.0	COG5485@1|root,COG5485@2|Bacteria,1VDAX@1239|Firmicutes	1239|Firmicutes	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
CMS1_k127_3016798_8	1211844.CBLM010000164_gene1371	9.247e-22	96.0	COG1484@1|root,COG1484@2|Bacteria,1TPPI@1239|Firmicutes,3VUP1@526524|Erysipelotrichia	526524|Erysipelotrichia	L	Bacterial dnaA  protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CMS1_k127_3016798_6	865861.AZSU01000003_gene1896	1.013e-31	125.0	COG1484@1|root,COG1484@2|Bacteria,1TPPI@1239|Firmicutes,24DKZ@186801|Clostridia,36I94@31979|Clostridiaceae	186801|Clostridia	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
CMS1_k127_30211_2	665571.STHERM_c10260	1.67e-23	102.0	COG0261@1|root,COG0261@2|Bacteria,2J7PP@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
CMS1_k127_30211_3	1128398.Curi_c19840	1e-09	63.0	COG2868@1|root,COG2868@2|Bacteria	2|Bacteria	J	Cysteine protease Prp	ysxB	-	-	ko:K07584	-	-	-	-	ko00000	-	-	-	Peptidase_Prp
CMS1_k127_30211_1	1094508.Tsac_2106	2.247e-34	133.0	COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia,42GQM@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
CMS1_k127_30211_0	990073.ATHU01000001_gene735	1.148e-94	318.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2YMGX@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
CMS1_k127_3022013_3	573413.Spirs_3787	3.962e-35	139.0	COG2114@1|root,COG2114@2|Bacteria,2J9VX@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3022013_2	573413.Spirs_3788	3.05e-51	194.0	COG2114@1|root,COG2114@2|Bacteria,2JAZ7@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3022013_1	1237149.C900_02701	9.704e-53	193.0	COG2860@1|root,COG2860@2|Bacteria,4NEXS@976|Bacteroidetes,47PWQ@768503|Cytophagia	976|Bacteroidetes	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
CMS1_k127_3022013_0	1232410.KI421424_gene1594	1.937e-55	201.0	COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,42R3P@68525|delta/epsilon subdivisions,2WMVW@28221|Deltaproteobacteria,43VBD@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Phospholipase A1	-	-	3.1.1.32,3.1.1.4	ko:K01058	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110	-	R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000	-	-	-	PLA1
CMS1_k127_3026979_10	237368.SCABRO_01860	3.143e-07	61.0	COG2905@1|root,COG3290@1|root,COG2905@2|Bacteria,COG3290@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,HATPase_c_5,PAS,PAS_9,SpoIIE,cNMP_binding
CMS1_k127_3026979_7	1321778.HMPREF1982_03608	7.644e-29	119.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,24HJF@186801|Clostridia,26CTD@186813|unclassified Clostridiales	186801|Clostridia	NT	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
CMS1_k127_3026979_5	1408473.JHXO01000001_gene2477	1.055e-86	295.0	COG0157@1|root,COG0157@2|Bacteria,4NDXF@976|Bacteroidetes,2FMJM@200643|Bacteroidia	976|Bacteroidetes	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
CMS1_k127_3026979_1	926692.AZYG01000019_gene249	1.405e-253	798.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,3WACS@53433|Halanaerobiales	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
CMS1_k127_3026979_6	665571.STHERM_c07820	4.156e-54	196.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	metW	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	MetW
CMS1_k127_3026979_3	96561.Dole_0752	6.273e-136	442.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,42N1M@68525|delta/epsilon subdivisions,2WJRJ@28221|Deltaproteobacteria,2MIEA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Homoserine_dh,NAD_binding_3
CMS1_k127_3026979_4	56780.SYN_02638	9.098e-112	387.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria,2MQYC@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_10,Fer4_8,Nitrate_red_gam
CMS1_k127_3026979_0	869213.JCM21142_41533	0.0	1056.0	COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,47MRY@768503|Cytophagia	976|Bacteroidetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
CMS1_k127_3026979_9	1125725.HMPREF1325_0181	3.898e-16	82.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS1_k127_3026979_2	1123487.KB892834_gene2653	5.528e-241	756.0	COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,2W0A1@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Phosphofructokinase	-	-	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
CMS1_k127_3026979_8	694427.Palpr_2699	5.311e-19	87.0	COG2345@1|root,COG2345@2|Bacteria,4NYUQ@976|Bacteroidetes,2FVNT@200643|Bacteroidia	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3032199_0	309799.DICTH_0388	3.24e-99	339.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	lpdA	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0005759,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009507,GO:0009536,GO:0009987,GO:0010035,GO:0010038,GO:0015036,GO:0016020,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0017144,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019464,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0035639,GO:0036094,GO:0036211,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044455,GO:0044464,GO:0045239,GO:0045240,GO:0045250,GO:0045252,GO:0045254,GO:0045271,GO:0046390,GO:0046395,GO:0046483,GO:0046496,GO:0046686,GO:0046872,GO:0046914,GO:0048037,GO:0048046,GO:0050660,GO:0050662,GO:0050896,GO:0050897,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0065007,GO:0065008,GO:0070013,GO:0070469,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0106077,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204,GO:1990234	1.16.1.1,1.8.1.4	ko:K00382,ko:K00520	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_1869,iE2348C_1286.E2348C_4372,iEcolC_1368.EcolC_3543,iJN746.PP_4187,iPC815.YPO3417,iSFV_1184.SFV_0107,iUMN146_1321.UM146_23385	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
CMS1_k127_3039570_0	1227352.C173_31976	9.389e-25	114.0	COG4385@1|root,COG4385@2|Bacteria,1UZ1H@1239|Firmicutes,4HAFG@91061|Bacilli,26UC4@186822|Paenibacillaceae	91061|Bacilli	S	Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
CMS1_k127_3039570_1	1195236.CTER_3463	2.437e-12	81.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	BACON,Big_2,CARDB,Cadherin,Calx-beta,DUF3739,PKD,Peptidase_S74,SLH
CMS1_k127_3039570_2	1291050.JAGE01000001_gene2807	3.346e-10	74.0	COG2911@1|root,COG2911@2|Bacteria,1VRRC@1239|Firmicutes,24F4N@186801|Clostridia	186801|Clostridia	S	Chaperone of endosialidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
CMS1_k127_3039570_3	394503.Ccel_1519	3.522e-08	68.0	COG2911@1|root,COG2911@2|Bacteria,1VRRC@1239|Firmicutes,24F4N@186801|Clostridia,36QY9@31979|Clostridiaceae	186801|Clostridia	S	Chaperone of endosialidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
CMS1_k127_3042072_0	1304284.L21TH_0883	2.575e-221	714.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,36DR6@31979|Clostridiaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
CMS1_k127_3042072_10	1216967.L100_06592	0.0001157	50.0	COG0724@1|root,COG0724@2|Bacteria,4NT1J@976|Bacteroidetes,1I4VC@117743|Flavobacteriia,34RNQ@308865|Elizabethkingia	976|Bacteroidetes	S	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS1_k127_3042072_2	706587.Desti_1112	3.53e-97	323.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2MQ9P@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
CMS1_k127_3042072_1	1278307.KB906999_gene6	3.057e-180	578.0	COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,1SYCI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Guanine deaminase	guaD	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	iEC55989_1330.EC55989_3170,iECED1_1282.ECED1_3343,iECIAI1_1343.ECIAI1_3003,iECSE_1348.ECSE_3147	Amidohydro_1
CMS1_k127_3042072_3	289376.THEYE_A0592	3.088e-88	306.0	COG1030@1|root,COG1030@2|Bacteria,3J0WF@40117|Nitrospirae	40117|Nitrospirae	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
CMS1_k127_3042072_9	665571.STHERM_c11080	9.483e-05	55.0	COG1413@1|root,COG1413@2|Bacteria,2J5WK@203691|Spirochaetes	203691|Spirochaetes	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS1_k127_3042072_8	1347086.CCBA010000010_gene1740	5.529e-25	116.0	COG3458@1|root,COG3458@2|Bacteria,1V2Z0@1239|Firmicutes,4IRU6@91061|Bacilli,1ZQXC@1386|Bacillus	91061|Bacilli	Q	Acetyl xylan esterase (AXE1)	cah3	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
CMS1_k127_3042072_6	755732.Fluta_3447	3.179e-41	161.0	COG2518@1|root,COG2518@2|Bacteria,4NFCU@976|Bacteroidetes,1HXFE@117743|Flavobacteriia,2PAS7@246874|Cryomorphaceae	976|Bacteroidetes	O	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS1_k127_3042072_5	412419.BDU_236	6.918e-54	213.0	COG0457@1|root,COG2304@1|root,COG3391@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes	203691|Spirochaetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
CMS1_k127_3042072_4	335543.Sfum_2097	2.046e-64	229.0	COG2207@1|root,COG2207@2|Bacteria,1QZ48@1224|Proteobacteria,42QVH@68525|delta/epsilon subdivisions,2X7Q8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS1_k127_3042072_7	439235.Dalk_2512	1.234e-34	134.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2MI64@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS1_k127_3050944_0	877455.Metbo_2153	9.088e-222	718.0	COG1002@1|root,COG2810@1|root,arCOG02636@1|root,arCOG08946@1|root,arCOG02635@2157|Archaea,arCOG02636@2157|Archaea,arCOG05724@2157|Archaea,arCOG08946@2157|Archaea,2Y89V@28890|Euryarchaeota	28890|Euryarchaeota	LV	Type I restriction-modification system methyltransferase subunit	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,HSDR_N,N6_Mtase,TaqI_C
CMS1_k127_3050944_6	1124780.ANNU01000046_gene2230	9.257e-17	79.0	COG0286@1|root,COG0286@2|Bacteria,4NGGB@976|Bacteroidetes,47MRS@768503|Cytophagia	976|Bacteroidetes	V	N-6 DNA Methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
CMS1_k127_3050944_4	522772.Dacet_0699	1.114e-35	142.0	COG0640@1|root,COG2865@1|root,COG0640@2|Bacteria,COG2865@2|Bacteria,2GG04@200930|Deferribacteres	200930|Deferribacteres	K	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,HATPase_c_4,TrmB
CMS1_k127_3050944_1	1408473.JHXO01000013_gene548	1.546e-69	243.0	2A5H9@1|root,30U7G@2|Bacteria,4NPEP@976|Bacteroidetes,2FXPZ@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3050944_5	1046714.AMRX01000006_gene3274	2.444e-20	99.0	COG0515@1|root,COG0515@2|Bacteria,1QZ10@1224|Proteobacteria,1S5Y1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	Domain of unknown function (DUF4328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4328
CMS1_k127_3050944_2	1403819.BATR01000162_gene5329	1.64e-50	190.0	2DZNQ@1|root,32VEU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3050944_8	391612.CY0110_09146	2.794e-08	61.0	2F3J5@1|root,33WCQ@2|Bacteria,1GDPZ@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3050944_3	301.JNHE01000003_gene1919	1.341e-38	150.0	2DMTX@1|root,32TP0@2|Bacteria,1N2JP@1224|Proteobacteria,1SB3B@1236|Gammaproteobacteria,1YJ4C@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ntox24
CMS1_k127_3054014_2	1121904.ARBP01000002_gene7230	3.007e-40	156.0	COG0701@1|root,COG2608@1|root,COG0701@2|Bacteria,COG2608@2|Bacteria,4NDUJ@976|Bacteroidetes,47TYD@768503|Cytophagia	976|Bacteroidetes	P	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1,HMA
CMS1_k127_3054014_3	272562.CA_C2242	3.394e-39	149.0	COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia,36JIC@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	cadC	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
CMS1_k127_3054014_4	176090.SSIN_1859	5.856e-34	136.0	COG4088@1|root,COG4088@2|Bacteria,1UP39@1239|Firmicutes	1239|Firmicutes	F	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,AAA_33
CMS1_k127_3054014_1	1121373.KB903621_gene1785	2.161e-57	207.0	COG0518@1|root,COG0518@2|Bacteria,4NMFC@976|Bacteroidetes,47QX7@768503|Cytophagia	976|Bacteroidetes	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
CMS1_k127_3054014_0	1121405.dsmv_1960	2.698e-65	231.0	COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2WPMI@28221|Deltaproteobacteria,2MM47@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
CMS1_k127_3056211_3	436308.Nmar_0527	7.153e-21	94.0	COG1278@1|root,arCOG02983@2157|Archaea,41T9B@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
CMS1_k127_3056211_0	935948.KE386494_gene183	5.882e-102	345.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,42F28@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM acetylornithine and succinylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS1_k127_3056211_2	595494.Tola_1404	1.62e-25	116.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS1_k127_3056211_4	573061.Clocel_3665	1.12e-17	94.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,24A6D@186801|Clostridia,36G9K@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_3056211_1	237368.SCABRO_00429	1.761e-67	247.0	COG0771@1|root,COG0771@2|Bacteria,2IX53@203682|Planctomycetes	203682|Planctomycetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
CMS1_k127_3062877_0	580331.Thit_0201	2.341e-91	321.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,42F4Y@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM glycoside hydrolase family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
CMS1_k127_3062877_1	373903.Hore_12830	1.795e-61	224.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,3WAKU@53433|Halanaerobiales	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
CMS1_k127_3063251_3	1121035.AUCH01000004_gene429	1.441e-28	117.0	COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria	1224|Proteobacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
CMS1_k127_3063251_2	880073.Calab_1282	1.106e-53	194.0	COG1443@1|root,COG1443@2|Bacteria,2NQ8N@2323|unclassified Bacteria	2|Bacteria	I	NUDIX domain	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
CMS1_k127_3063251_1	555088.DealDRAFT_1267	5.94e-57	215.0	COG1721@1|root,COG1721@2|Bacteria,1UYJ3@1239|Firmicutes,24FK2@186801|Clostridia	186801|Clostridia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS1_k127_3063251_0	292459.STH463	9.781e-104	346.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia	186801|Clostridia	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS1_k127_3067261_0	1132855.KB913035_gene1153	3.447e-32	135.0	COG0697@1|root,COG0697@2|Bacteria,1PBZ7@1224|Proteobacteria,2WHYZ@28216|Betaproteobacteria,2KNQ4@206350|Nitrosomonadales	206350|Nitrosomonadales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS1_k127_3067261_2	1211035.CD30_04180	6.155e-19	101.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,3IW0D@400634|Lysinibacillus	91061|Bacilli	NT	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,sCache_2
CMS1_k127_3067261_1	641524.ADICYQ_0782	9.918e-28	123.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS1_k127_3067261_3	574376.BAMA_10955	1.769e-07	61.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,1ZBEA@1386|Bacillus	91061|Bacilli	NT	chemotaxis protein	mcpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
CMS1_k127_3072316_0	944480.ATUV01000002_gene240	1.441e-171	546.0	COG0562@1|root,COG0562@2|Bacteria,1MV4H@1224|Proteobacteria,42NAB@68525|delta/epsilon subdivisions,2WUXH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,NAD_binding_8
CMS1_k127_3072316_1	1235803.C825_00126	2.063e-87	295.0	COG0463@1|root,COG0463@2|Bacteria,4NK1T@976|Bacteroidetes,2FPN1@200643|Bacteroidia,22YJG@171551|Porphyromonadaceae	976|Bacteroidetes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_3073536_5	1163407.UU7_11864	1.019e-19	98.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
CMS1_k127_3073536_0	1313304.CALK_0105	1.912e-263	825.0	COG1048@1|root,COG1048@2|Bacteria	2|Bacteria	C	aconitate hydratase activity	dmdA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
CMS1_k127_3073536_6	1045858.Bint_2911	1.821e-13	81.0	COG2227@1|root,COG3677@1|root,COG3980@1|root,COG2227@2|Bacteria,COG3677@2|Bacteria,COG3980@2|Bacteria,2JBIU@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase domain	ubiG	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS1_k127_3073536_3	865861.AZSU01000002_gene2983	9.975e-48	181.0	COG1861@1|root,COG1861@2|Bacteria,1U4YD@1239|Firmicutes,24B0X@186801|Clostridia,36GFB@31979|Clostridiaceae	186801|Clostridia	M	Cytidylyltransferase	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3
CMS1_k127_3073536_2	869209.Tresu_1174	3.244e-49	194.0	COG0535@1|root,COG0535@2|Bacteria,2J6HP@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
CMS1_k127_3073536_4	748449.Halha_1843	2.113e-20	102.0	COG0457@1|root,COG0760@1|root,COG0457@2|Bacteria,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,3WBSJ@53433|Halanaerobiales	186801|Clostridia	O	PPIC-type PPIASE domain	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
CMS1_k127_3073536_1	398767.Glov_2832	1.002e-71	250.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,43TAQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
CMS1_k127_3078603_1	485918.Cpin_1364	8.157e-32	132.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_3078603_0	485918.Cpin_1363	3.282e-98	339.0	COG2303@1|root,COG2303@2|Bacteria,4NEF2@976|Bacteroidetes,1IXR8@117747|Sphingobacteriia	976|Bacteroidetes	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
CMS1_k127_3078738_0	1307761.L21SP2_0548	2.842e-100	347.0	COG0366@1|root,COG0366@2|Bacteria,2J9X3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_309205_3	1195236.CTER_3475	4.584e-44	166.0	COG1652@1|root,COG1652@2|Bacteria,1V83T@1239|Firmicutes,24KBD@186801|Clostridia,3WMI2@541000|Ruminococcaceae	186801|Clostridia	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
CMS1_k127_309205_1	1227352.C173_31946	4.387e-77	270.0	COG3500@1|root,COG3500@2|Bacteria,1V1XA@1239|Firmicutes,4HGPH@91061|Bacilli,26RWA@186822|Paenibacillaceae	91061|Bacilli	S	Phage protein D	-	-	-	ko:K06905	-	-	-	-	ko00000	-	-	-	Phage_GPD
CMS1_k127_309205_2	489825.LYNGBM3L_03970	5.007e-59	211.0	COG3501@1|root,COG3501@2|Bacteria,1G6H3@1117|Cyanobacteria,1HBBA@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Phage-related baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_309205_4	1034769.KB910518_gene1554	1.747e-28	119.0	COG3628@1|root,COG3628@2|Bacteria,1VCD7@1239|Firmicutes,4HKUU@91061|Bacilli,26YDR@186822|Paenibacillaceae	91061|Bacilli	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
CMS1_k127_309205_0	394503.Ccel_1512	1.165e-137	496.0	COG3299@1|root,COG3299@2|Bacteria,1TRCX@1239|Firmicutes,24BAX@186801|Clostridia,36K5Y@31979|Clostridiaceae	186801|Clostridia	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
CMS1_k127_309205_6	1195236.CTER_3469	9.56e-23	114.0	COG3299@1|root,COG3299@2|Bacteria,1VT3P@1239|Firmicutes,24D1X@186801|Clostridia,3WRZX@541000|Ruminococcaceae	186801|Clostridia	S	homolog of phage Mu protein gp47	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_309205_5	1541065.JRFE01000014_gene1230	5.819e-24	118.0	COG2133@1|root,COG3055@1|root,COG3266@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,COG3266@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	prtV	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.2.1.51	ko:K01206,ko:K09607,ko:K12056	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02044,ko04147	3.A.7.11.1	GH29	-	DUF1080,PKD,Peptidase_M6
CMS1_k127_3094938_1	436114.SYO3AOP1_1376	1.109e-35	143.0	COG1521@1|root,COG1521@2|Bacteria,2G48P@200783|Aquificae	200783|Aquificae	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
CMS1_k127_3094938_0	1408422.JHYF01000004_gene1505	1.839e-49	183.0	COG0563@1|root,COG0563@2|Bacteria,1UJD5@1239|Firmicutes,24BY9@186801|Clostridia,36GFS@31979|Clostridiaceae	186801|Clostridia	F	adenylate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
CMS1_k127_3115109_0	1250005.PHEL85_2714	7.889e-127	428.0	COG4585@1|root,COG4585@2|Bacteria,4NEZA@976|Bacteroidetes,1HZGM@117743|Flavobacteriia	976|Bacteroidetes	T	Signal Transduction Histidine Kinase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7,TPR_8
CMS1_k127_3115109_1	1317122.ATO12_03555	8.086e-76	256.0	COG0454@1|root,COG0456@2|Bacteria,4NQV0@976|Bacteroidetes,1I1XX@117743|Flavobacteriia	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
CMS1_k127_3115109_2	880070.Cycma_3459	1.344e-57	202.0	COG5499@1|root,COG5499@2|Bacteria,4NNXF@976|Bacteroidetes,47R0B@768503|Cytophagia	976|Bacteroidetes	K	transcription regulator containing HTH domain	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3
CMS1_k127_3115109_3	886377.Murru_2409	1.035e-46	169.0	COG4680@1|root,COG4680@2|Bacteria,4NQ54@976|Bacteroidetes,1I2RY@117743|Flavobacteriia	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	ko:K19166	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HigB_toxin
CMS1_k127_3115109_4	886377.Murru_2025	1.262e-08	56.0	COG1670@1|root,COG1670@2|Bacteria,4NRI6@976|Bacteroidetes	976|Bacteroidetes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
CMS1_k127_3147463_0	857293.CAAU_2072	7.716e-123	402.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36DYU@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	msmX	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
CMS1_k127_3147463_1	2340.JV46_08590	4.393e-70	250.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN2K@1236|Gammaproteobacteria,1JBUX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Periplasmic binding protein-like domain	-	-	-	ko:K02525,ko:K02529,ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_3147463_2	1094508.Tsac_0151	4.518e-26	121.0	COG1653@1|root,COG1653@2|Bacteria,1TQ0V@1239|Firmicutes,2481M@186801|Clostridia,42IHK@68295|Thermoanaerobacterales	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027,ko:K10188	ko02010,map02010	M00199,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.4	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_315052_3	1191523.MROS_1666	4.46e-26	114.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	VPA0559	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
CMS1_k127_315052_1	1232437.KL661988_gene227	1.312e-66	243.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42QGA@68525|delta/epsilon subdivisions,2WJYS@28221|Deltaproteobacteria,2MI4W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS1_k127_315052_2	1408473.JHXO01000005_gene1472	1.237e-56	206.0	COG2834@1|root,COG2834@2|Bacteria,4NIT5@976|Bacteroidetes,2FSCB@200643|Bacteroidia	976|Bacteroidetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS1_k127_315052_4	665571.STHERM_c22490	5.942e-22	98.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_20
CMS1_k127_315052_5	1168289.AJKI01000002_gene2352	1.305e-18	94.0	COG4915@1|root,COG4915@2|Bacteria	2|Bacteria	S	5-bromo-4-chloroindolyl phosphate hydrolysis protein	xpaC	-	-	-	-	-	-	-	-	-	-	-	Halogen_Hydrol
CMS1_k127_315052_0	1121403.AUCV01000020_gene3110	6.131e-108	361.0	COG1244@1|root,COG1244@2|Bacteria	2|Bacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	-
CMS1_k127_315052_6	258594.RPA2406	1.543e-09	68.0	COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2U0DV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	ADP-ribosylglycohydrolase	draG	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH,Inositol_P
CMS1_k127_315074_1	926561.KB900617_gene1358	3.778e-56	207.0	COG0366@1|root,COG1974@1|root,COG0366@2|Bacteria,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,HTH_3,PKD,Peptidase_S24,SLH
CMS1_k127_315074_0	373903.Hore_19550	3.738e-129	460.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,3WBKI@53433|Halanaerobiales	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3372,PUD
CMS1_k127_315074_2	1499685.CCFJ01000041_gene1037	1.715e-22	112.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,1ZBEA@1386|Bacillus	91061|Bacilli	NT	chemotaxis protein	yoaH	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
CMS1_k127_3155822_2	517418.Ctha_1019	1.759e-54	197.0	28PMV@1|root,2ZCAQ@2|Bacteria	2|Bacteria	S	COG NOG23385 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3155822_1	573413.Spirs_3930	2.285e-63	219.0	COG0454@1|root,COG0456@2|Bacteria,2J948@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
CMS1_k127_3155822_0	1125699.HMPREF9194_00352	1.245e-109	357.0	COG0110@1|root,COG0110@2|Bacteria,2J6T5@203691|Spirochaetes	203691|Spirochaetes	M	COGs COG0110 Acetyltransferase (isoleucine patch superfamily)	-	-	-	ko:K18234	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Hexapep
CMS1_k127_3155822_3	572479.Hprae_1048	3.703e-32	128.0	COG0491@1|root,COG0491@2|Bacteria,1V0KE@1239|Firmicutes,24D1B@186801|Clostridia	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_3155822_4	573413.Spirs_4183	2.672e-08	55.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yiaC	-	2.3.1.1	ko:K03826,ko:K22476	ko00220,ko01210,ko01230,map00220,map01210,map01230	-	R00259	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_10,Acetyltransf_7
CMS1_k127_318225_2	1128398.Curi_c12290	1.743e-77	262.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,268P4@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
CMS1_k127_318225_1	555088.DealDRAFT_1228	4.062e-240	746.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,42JJB@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
CMS1_k127_318225_3	744872.Spica_0938	1.923e-55	199.0	COG1396@1|root,COG1396@2|Bacteria,2J70F@203691|Spirochaetes	203691|Spirochaetes	K	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
CMS1_k127_318225_0	1122599.AUGR01000022_gene1630	9.055e-246	786.0	COG0438@1|root,COG0613@1|root,COG0438@2|Bacteria,COG0613@2|Bacteria,1MUB7@1224|Proteobacteria,1RQYE@1236|Gammaproteobacteria,1XQ5I@135619|Oceanospirillales	135619|Oceanospirillales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
CMS1_k127_3192888_2	1122135.KB893168_gene1855	2.398e-12	77.0	2E7B7@1|root,331UM@2|Bacteria,1NB58@1224|Proteobacteria,2UHAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3192888_1	720554.Clocl_1477	4.301e-29	126.0	COG1714@1|root,COG1714@2|Bacteria,1UWM8@1239|Firmicutes,24T0F@186801|Clostridia,3WIU6@541000|Ruminococcaceae	186801|Clostridia	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
CMS1_k127_3192888_0	391625.PPSIR1_30983	9.133e-48	184.0	COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,43837@68525|delta/epsilon subdivisions,2X3D5@28221|Deltaproteobacteria,2YVHN@29|Myxococcales	28221|Deltaproteobacteria	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
CMS1_k127_3200146_3	289376.THEYE_A1852	4.71e-116	378.0	COG0543@1|root,COG0543@2|Bacteria,3J0UF@40117|Nitrospirae	40117|Nitrospirae	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
CMS1_k127_3200146_2	289376.THEYE_A1853	3.455e-117	381.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	hoxY	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
CMS1_k127_3200146_1	56780.SYN_02222	1.542e-191	606.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42RHV@68525|delta/epsilon subdivisions,2WNH5@28221|Deltaproteobacteria,2MSJH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Nickel-dependent hydrogenase	hyhL	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
CMS1_k127_3200146_6	593117.TGAM_0236	4.764e-15	81.0	COG0680@1|root,arCOG04429@2157|Archaea,2Y0IM@28890|Euryarchaeota,2448E@183968|Thermococci	183968|Thermococci	O	Hydrogenase maturation protease	-	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
CMS1_k127_3200146_5	1237149.C900_00981	2.601e-56	205.0	COG2227@1|root,COG2227@2|Bacteria,4P2YS@976|Bacteroidetes,47UM5@768503|Cytophagia	976|Bacteroidetes	H	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS1_k127_3200146_0	522772.Dacet_2985	2.595e-198	628.0	COG0168@1|root,COG0168@2|Bacteria,2GEUM@200930|Deferribacteres	200930|Deferribacteres	P	Cation transport protein	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
CMS1_k127_3200146_4	717231.Flexsi_0217	2.08e-74	259.0	COG0569@1|root,COG0569@2|Bacteria,2GF6N@200930|Deferribacteres	200930|Deferribacteres	C	Putative NAD(P)-binding	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS1_k127_3202964_9	1229487.AMYW01000001_gene4012	9.515e-05	50.0	2DG02@1|root,2ZTWM@2|Bacteria,4P8YB@976|Bacteroidetes,1IBRJ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3202964_1	945713.IALB_2046	8.156e-95	323.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	agmM	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
CMS1_k127_3202964_5	1379698.RBG1_1C00001G0461	9.605e-30	124.0	COG2143@1|root,COG2143@2|Bacteria	2|Bacteria	O	COG2143 Thioredoxin-related protein	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7
CMS1_k127_3202964_2	909663.KI867149_gene3195	5.475e-67	237.0	COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2WIMS@28221|Deltaproteobacteria,2MRUI@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Menaquinone biosynthesis	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
CMS1_k127_3202964_7	272632.MSC_0443	8.8e-10	67.0	COG0775@1|root,COG0775@2|Bacteria,3WTZS@544448|Tenericutes	544448|Tenericutes	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtn	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS1_k127_3202964_8	701347.Entcl_2581	1.215e-06	54.0	COG1366@1|root,COG1366@2|Bacteria,1MZE8@1224|Proteobacteria,1RTYX@1236|Gammaproteobacteria,3X42W@547|Enterobacter	1236|Gammaproteobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS1_k127_3202964_3	1174504.AJTN02000203_gene2773	1.766e-45	169.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,4HH2Z@91061|Bacilli,1ZC7I@1386|Bacillus	91061|Bacilli	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
CMS1_k127_3202964_4	1203606.HMPREF1526_00405	7.658e-42	160.0	COG0693@1|root,COG0693@2|Bacteria,1V3WB@1239|Firmicutes,24HGU@186801|Clostridia,36J1Q@31979|Clostridiaceae	186801|Clostridia	S	DJ-1 family	yajL	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
CMS1_k127_3202964_0	335543.Sfum_3083	5.247e-190	603.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MQ6K@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM AICARFT IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CMS1_k127_3202964_6	1123511.KB905847_gene3064	2.525e-25	109.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,4H4YH@909932|Negativicutes	909932|Negativicutes	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
CMS1_k127_3203208_0	526218.Sterm_0576	1.428e-122	401.0	COG1087@1|root,COG1087@2|Bacteria,378JK@32066|Fusobacteria	32066|Fusobacteria	M	UDP-glucose 4-epimerase	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS1_k127_3203208_1	1121434.AULY01000006_gene815	1.7e-54	202.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,42UV6@68525|delta/epsilon subdivisions,2WP1R@28221|Deltaproteobacteria,2MAEX@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM 6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
CMS1_k127_3203208_2	326298.Suden_0251	1.446e-35	140.0	COG2731@1|root,COG2731@2|Bacteria,1N8IZ@1224|Proteobacteria,42W19@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	Domain of unknown function (DUF386)	yiaL	GO:0008150,GO:0009314,GO:0009628,GO:0050896	-	-	-	-	-	-	-	-	-	-	DUF386
CMS1_k127_3203208_3	537972.ABQU01000028_gene507	5.272e-05	48.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2YNZT@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
CMS1_k127_3213875_1	1499967.BAYZ01000019_gene6264	7.326e-58	208.0	COG0546@1|root,COG0546@2|Bacteria,2NPKQ@2323|unclassified Bacteria	2|Bacteria	S	Haloacid dehalogenase-like hydrolase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_3213875_0	1121091.AUMP01000001_gene539	1.868e-129	425.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,4H9PE@91061|Bacilli	91061|Bacilli	E	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_3213875_2	992406.RIA_1568	5.305e-06	53.0	COG3103@1|root,COG3103@2|Bacteria,4NRNZ@976|Bacteroidetes,1I3T7@117743|Flavobacteriia	976|Bacteroidetes	T	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
CMS1_k127_3216060_0	289376.THEYE_A1377	5.765e-144	469.0	COG2204@1|root,COG2204@2|Bacteria,3J0C2@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS1_k127_3216060_3	1307761.L21SP2_3292	1.24e-55	216.0	COG5000@1|root,COG5000@2|Bacteria,2J753@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
CMS1_k127_3216060_5	926561.KB900618_gene377	9.247e-22	96.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia,3WC24@53433|Halanaerobiales	186801|Clostridia	G	TIGRFAM Phosphotransferase System HPr (HPr) Family	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
CMS1_k127_3216060_1	697281.Mahau_1837	2.746e-87	298.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,42FBJ@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
CMS1_k127_3216060_4	522772.Dacet_1310	1.009e-23	111.0	COG1544@1|root,COG1544@2|Bacteria,2GFDP@200930|Deferribacteres	200930|Deferribacteres	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
CMS1_k127_3216060_2	272563.CD630_31760	5.627e-71	254.0	COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,2480F@186801|Clostridia,25R2W@186804|Peptostreptococcaceae	186801|Clostridia	K	RNA polymerase	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
CMS1_k127_3219888_7	871968.DESME_02145	5.399e-16	82.0	COG0454@1|root,COG0456@2|Bacteria,1VHVK@1239|Firmicutes,25E0E@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS1_k127_3219888_5	313603.FB2170_11066	8.178e-61	216.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	thiJ	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,YHS
CMS1_k127_3219888_4	272563.CD630_31650	2.65e-71	246.0	COG4335@1|root,COG4335@2|Bacteria,1TPRQ@1239|Firmicutes,24C9P@186801|Clostridia,25RFN@186804|Peptostreptococcaceae	186801|Clostridia	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
CMS1_k127_3219888_3	56780.SYN_02918	1.727e-73	256.0	COG0778@1|root,COG2768@1|root,COG0778@2|Bacteria,COG2768@2|Bacteria,1R42D@1224|Proteobacteria,42Q57@68525|delta/epsilon subdivisions,2WNIW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_7,Fer4_9,Nitroreductase
CMS1_k127_3219888_1	1265505.ATUG01000001_gene3015	2.013e-125	422.0	COG2199@1|root,COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42RC2@68525|delta/epsilon subdivisions,2X8JD@28221|Deltaproteobacteria,2MJQ0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9
CMS1_k127_3219888_2	402626.Rpic_4126	2.772e-83	288.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VQ62@28216|Betaproteobacteria,1K2D4@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF
CMS1_k127_3219888_0	1168034.FH5T_14950	2.872e-146	470.0	COG2334@1|root,COG2334@2|Bacteria,4NG92@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1679)	-	-	-	-	-	-	-	-	-	-	-	-	EcKinase
CMS1_k127_3223920_7	1121403.AUCV01000022_gene3495	6.355e-07	52.0	COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,42NYN@68525|delta/epsilon subdivisions,2WJFE@28221|Deltaproteobacteria,2MHZZ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
CMS1_k127_3223920_4	1517682.HW49_08005	4.104e-34	142.0	COG0614@1|root,COG0614@2|Bacteria,4PIZ2@976|Bacteroidetes,2FQAM@200643|Bacteroidia,22XPH@171551|Porphyromonadaceae	976|Bacteroidetes	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
CMS1_k127_3223920_1	748727.CLJU_c05830	2.165e-58	214.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,36EB1@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
CMS1_k127_3223920_2	373903.Hore_00190	2.476e-57	209.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,3WAET@53433|Halanaerobiales	186801|Clostridia	HP	PFAM ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS1_k127_3223920_3	1191523.MROS_1997	1.159e-34	140.0	COG0811@1|root,COG0811@2|Bacteria	2|Bacteria	U	bacteriocin transport	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CMS1_k127_3223920_6	926561.KB900617_gene1941	2.832e-09	63.0	COG0848@1|root,COG0848@2|Bacteria,1W1VU@1239|Firmicutes	1239|Firmicutes	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
CMS1_k127_3223920_5	545694.TREPR_0519	1.491e-10	69.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_2,TonB_C
CMS1_k127_3223920_0	13035.Dacsa_1230	9.595e-197	653.0	COG0841@1|root,COG0841@2|Bacteria,1G21T@1117|Cyanobacteria	1117|Cyanobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS1_k127_3226055_2	1511.CLOST_0136	3.357e-114	381.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,25QHA@186804|Peptostreptococcaceae	186801|Clostridia	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS1_k127_3226055_1	926561.KB900617_gene1434	1.141e-115	380.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,3WAJI@53433|Halanaerobiales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
CMS1_k127_3226055_0	1123288.SOV_2c11030	2.879e-165	528.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,4H1XV@909932|Negativicutes	909932|Negativicutes	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
CMS1_k127_3226055_4	1125701.HMPREF1221_01863	1.861e-14	78.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS1_k127_3226055_3	593750.Metfor_1976	1.716e-53	207.0	COG2208@1|root,arCOG02362@1|root,arCOG02362@2157|Archaea,arCOG06893@2157|Archaea,2Y2MD@28890|Euryarchaeota	2157|Archaea	T	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
CMS1_k127_3226055_5	406327.Mevan_0025	0.0003087	50.0	COG0457@1|root,arCOG06519@2157|Archaea,2XYVX@28890|Euryarchaeota,23R6D@183939|Methanococci	183939|Methanococci	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
CMS1_k127_3235276_1	272562.CA_C2922	2.637e-97	326.0	COG2022@1|root,COG2022@2|Bacteria,1TQZ1@1239|Firmicutes,247TJ@186801|Clostridia,36G8Q@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
CMS1_k127_3235276_0	574087.Acear_1572	1.418e-102	344.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia,3WAE0@53433|Halanaerobiales	186801|Clostridia	C	Biotin and Thiamin Synthesis associated	thiH	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
CMS1_k127_3235276_2	926561.KB900617_gene2024	9.195e-41	154.0	COG0476@1|root,COG0476@2|Bacteria,1UYFC@1239|Firmicutes,247UZ@186801|Clostridia	186801|Clostridia	H	Thiamine biosynthesis protein ThiF	thiF	-	2.7.7.73	ko:K03148	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS-like
CMS1_k127_3235381_0	1121898.Q766_07370	6.332e-58	207.0	COG0791@1|root,COG0791@2|Bacteria,4NM7I@976|Bacteroidetes,1I4WI@117743|Flavobacteriia,2P0MF@237|Flavobacterium	976|Bacteroidetes	M	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
CMS1_k127_3235381_1	1120973.AQXL01000088_gene3240	2.927e-36	157.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,279IT@186823|Alicyclobacillaceae	91061|Bacilli	NT	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,MCPsignal,dCache_1
CMS1_k127_3236354_3	759914.BP951000_0893	8.491e-17	85.0	COG3951@1|root,COG3951@2|Bacteria	2|Bacteria	MNO	Flagellar rod assembly protein muramidase FlgJ	flgJ	-	-	ko:K02395,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02035	-	GH23	-	Rod-binding
CMS1_k127_3236354_1	1304875.JAFZ01000002_gene119	5.233e-68	243.0	COG1706@1|root,COG1706@2|Bacteria,3TA0P@508458|Synergistetes	508458|Synergistetes	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
CMS1_k127_3236354_4	1336249.JADW01000003_gene3788	1.445e-07	61.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2TT2A@28211|Alphaproteobacteria,4BMN5@82115|Rhizobiaceae	28211|Alphaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
CMS1_k127_3236354_0	573413.Spirs_1790	1.012e-121	395.0	COG4786@1|root,COG4786@2|Bacteria,2J57D@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein FlgG	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
CMS1_k127_3236354_2	526227.Mesil_1477	2.14e-18	87.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	ybfI	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
CMS1_k127_3240274_8	1396141.BATP01000030_gene3634	1.654e-14	86.0	COG3170@1|root,COG3210@1|root,COG3866@1|root,COG3170@2|Bacteria,COG3210@2|Bacteria,COG3866@2|Bacteria	2|Bacteria	G	Pectate lyase	pnlA	-	2.7.7.65,4.2.2.10	ko:K01732,ko:K02316,ko:K13590,ko:K20276,ko:K20541	ko02024,ko03030,ko04112,map02024,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko02000,ko03032	4.D.3.1.6	-	-	DUF3086,Pec_lyase_C,RicinB_lectin_2
CMS1_k127_3240274_4	439235.Dalk_2814	7.447e-30	123.0	COG2062@1|root,COG2062@2|Bacteria,1RGWQ@1224|Proteobacteria,42SEE@68525|delta/epsilon subdivisions,2WPM2@28221|Deltaproteobacteria,2MKBQ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Phosphohistidine phosphatase SixA	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
CMS1_k127_3240274_1	864702.OsccyDRAFT_4965	6.809e-142	460.0	COG1104@1|root,COG1104@2|Bacteria,1G0D5@1117|Cyanobacteria,1H7BA@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS1_k127_3240274_2	1121406.JAEX01000012_gene635	1.731e-89	302.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2M82B@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
CMS1_k127_3240274_3	509191.AEDB02000082_gene2562	2.88e-34	137.0	COG0454@1|root,COG0456@2|Bacteria,1V6YG@1239|Firmicutes,25DBM@186801|Clostridia,3WJBY@541000|Ruminococcaceae	186801|Clostridia	K	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3240274_6	1203550.HMPREF1475_01548	2.363e-23	103.0	COG1846@1|root,COG1846@2|Bacteria,4NWGX@976|Bacteroidetes,2G2KN@200643|Bacteroidia	976|Bacteroidetes	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
CMS1_k127_3240274_0	1168034.FH5T_05810	0.0	1042.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,4PKEU@976|Bacteroidetes,2FKZ0@200643|Bacteroidia	976|Bacteroidetes	P	Belongs to the sulfur carrier protein TusA family	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
CMS1_k127_3240274_9	1123277.KB893197_gene6111	1.843e-11	69.0	COG3203@1|root,COG4386@1|root,COG3203@2|Bacteria,COG4386@2|Bacteria,4PM6S@976|Bacteroidetes,47Y33@768503|Cytophagia	976|Bacteroidetes	M	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
CMS1_k127_3240274_11	1121929.KB898664_gene1283	1.609e-09	66.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.1,3.2.1.51,3.2.1.78	ko:K01176,ko:K01206,ko:K01218	ko00051,ko00500,ko00511,ko01100,ko02024,ko04973,map00051,map00500,map00511,map01100,map02024,map04973	-	R01332,R02108,R02112,R11262	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH13,GH26,GH29	-	Alpha_L_fucos,Calx-beta,Cellulase,Cohesin,DUF4091,F5_F8_type_C,Glyco_hydro_26
CMS1_k127_3240274_5	485916.Dtox_3480	2.168e-23	117.0	COG1409@1|root,COG1409@2|Bacteria,1TSSR@1239|Firmicutes,248DJ@186801|Clostridia	186801|Clostridia	O	PFAM Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Metallophos,Pur_ac_phosph_N
CMS1_k127_3240274_10	65071.PYU1_T005253	6.992e-10	72.0	COG1489@1|root,2SEBH@2759|Eukaryota	2759|Eukaryota	S	positive regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	CBM_25
CMS1_k127_3240274_7	381764.Fnod_0022	1.37e-17	98.0	COG1520@1|root,COG1520@2|Bacteria,2GD9T@200918|Thermotogae	200918|Thermotogae	S	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3248456_1	572480.Arnit_1347	6.912e-64	229.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2YQUV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
CMS1_k127_3248456_0	1307761.L21SP2_2376	1.163e-180	574.0	COG0183@1|root,COG0183@2|Bacteria,2JBB9@203691|Spirochaetes	203691|Spirochaetes	I	Thiolase, C-terminal domain	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
CMS1_k127_3248957_7	485915.Dret_0022	9.124e-17	82.0	292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,42RFG@68525|delta/epsilon subdivisions,2WPKN@28221|Deltaproteobacteria,2ME7H@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
CMS1_k127_3248957_6	522772.Dacet_1399	1.426e-33	138.0	COG3222@1|root,COG3222@2|Bacteria,2GFZD@200930|Deferribacteres	200930|Deferribacteres	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
CMS1_k127_3248957_0	1293054.HSACCH_00967	5.767e-133	439.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,3WA9W@53433|Halanaerobiales	186801|Clostridia	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
CMS1_k127_3248957_4	717231.Flexsi_2047	6.085e-50	185.0	COG0398@1|root,COG0398@2|Bacteria,2GFR0@200930|Deferribacteres	200930|Deferribacteres	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS1_k127_3248957_2	706587.Desti_0359	1.481e-93	315.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,42NDF@68525|delta/epsilon subdivisions,2WJPS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
CMS1_k127_3248957_1	926561.KB900617_gene1221	5.236e-112	370.0	COG3634@1|root,COG3634@2|Bacteria,1TPYN@1239|Firmicutes,24ET7@186801|Clostridia	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	ahpF	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Thioredoxin_3
CMS1_k127_3248957_3	1410668.JNKC01000001_gene1914	5.215e-64	226.0	COG3634@1|root,COG3634@2|Bacteria,1V40Z@1239|Firmicutes,24JKA@186801|Clostridia,36I22@31979|Clostridiaceae	186801|Clostridia	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
CMS1_k127_3248957_5	926561.KB900617_gene1910	6.462e-38	153.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3372,PUD
CMS1_k127_3249023_2	290512.Paes_1627	4.424e-155	492.0	COG1348@1|root,COG1348@2|Bacteria,1FDR5@1090|Chlorobi	1090|Chlorobi	F	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
CMS1_k127_3249023_6	880072.Desac_0351	5.564e-46	168.0	COG0347@1|root,COG0347@2|Bacteria,1RIX2@1224|Proteobacteria,42SFQ@68525|delta/epsilon subdivisions,2WPG3@28221|Deltaproteobacteria,2MRTZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K02589	-	-	-	-	ko00000	-	-	-	P-II
CMS1_k127_3249023_5	573413.Spirs_3006	1.926e-47	173.0	COG0347@1|root,COG0347@2|Bacteria,2J8HK@203691|Spirochaetes	203691|Spirochaetes	K	nitrogen regulatory protein P-II	-	-	-	ko:K02590	-	-	-	-	ko00000	-	-	-	P-II
CMS1_k127_3249023_0	290318.Cvib_1346	1.441e-267	831.0	COG2710@1|root,COG2710@2|Bacteria,1FDEX@1090|Chlorobi	1090|Chlorobi	C	TIGRFAM nitrogenase molybdenum-iron protein alpha chain	-	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
CMS1_k127_3249023_1	319225.Plut_1532	3.745e-230	719.0	COG2710@1|root,COG2710@2|Bacteria,1FDJS@1090|Chlorobi	1090|Chlorobi	C	This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation	-	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
CMS1_k127_3249023_7	194439.CT1541	5.537e-44	162.0	COG3411@1|root,COG3411@2|Bacteria,1FE2Q@1090|Chlorobi	1090|Chlorobi	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3249023_3	1515615.HQ41_02785	1.401e-50	207.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor,Peptidase_M73
CMS1_k127_3249023_4	1279017.AQYJ01000028_gene2277	3.587e-48	199.0	COG0366@1|root,COG0366@2|Bacteria,1MVQA@1224|Proteobacteria,1RPA4@1236|Gammaproteobacteria,46654@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG0366 Glycosidases	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amyl_C2,Alpha-amylase,Alpha-amylase_C,CBM26,CBM_20,CBM_48,PKD
CMS1_k127_3254560_5	1121403.AUCV01000016_gene4413	5.847e-22	97.0	2C06Z@1|root,3335S@2|Bacteria,1NI0C@1224|Proteobacteria,42X3F@68525|delta/epsilon subdivisions,2WT33@28221|Deltaproteobacteria,2MP40@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Nif11 domain	-	-	-	-	-	-	-	-	-	-	-	-	Nif11
CMS1_k127_3254560_6	913865.DOT_3433	5.763e-05	56.0	COG2374@1|root,COG4733@1|root,COG2374@2|Bacteria,COG4733@2|Bacteria,1TQ2T@1239|Firmicutes,24EP0@186801|Clostridia,265Y1@186807|Peptococcaceae	186801|Clostridia	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD,Paired_CXXCH_1,SLH,fn3
CMS1_k127_3254560_1	771875.Ferpe_0664	2.334e-142	461.0	COG0426@1|root,COG0426@2|Bacteria,2GCAS@200918|Thermotogae	200918|Thermotogae	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
CMS1_k127_3254560_3	1121091.AUMP01000001_gene319	6.799e-66	234.0	COG0726@1|root,COG0726@2|Bacteria,1TW97@1239|Firmicutes,4HDGU@91061|Bacilli	91061|Bacilli	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS1_k127_3254560_4	690850.Desaf_3069	3.636e-65	230.0	COG2173@1|root,COG2173@2|Bacteria,1N3QY@1224|Proteobacteria,42TQ8@68525|delta/epsilon subdivisions,2WNK8@28221|Deltaproteobacteria,2M9YV@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	ddpX	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
CMS1_k127_3254560_0	395961.Cyan7425_1501	3.999e-192	627.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1G1A0@1117|Cyanobacteria,3KH35@43988|Cyanothece	1117|Cyanobacteria	M	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
CMS1_k127_3254560_2	1499689.CCNN01000009_gene2721	2.033e-76	269.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,36EEA@31979|Clostridiaceae	186801|Clostridia	E	Cleaves the N-terminal amino acid of tripeptides	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_3257993_2	858215.Thexy_0472	2.631e-61	222.0	COG1924@1|root,COG1924@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,42FXK@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM ATPase, BadF BadG BcrA BcrD type	hgdC	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
CMS1_k127_3257993_5	1121441.AUCX01000035_gene3	1.682e-40	155.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X5TT@28221|Deltaproteobacteria,2MGVV@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	cheW	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS1_k127_3257993_0	35841.BT1A1_1584	1.082e-122	434.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,4HAQD@91061|Bacilli,1ZATW@1386|Bacillus	91061|Bacilli	NT	COG0643 Chemotaxis protein histidine kinase and related kinases	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
CMS1_k127_3257993_1	1151117.AJLF01000001_gene1035	5.138e-94	320.0	COG2201@1|root,arCOG02382@2157|Archaea,2XUKR@28890|Euryarchaeota,2433H@183968|Thermococci	183968|Thermococci	N	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
CMS1_k127_3257993_7	857293.CAAU_1695	6.128e-40	151.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,24HJF@186801|Clostridia,36IRR@31979|Clostridiaceae	186801|Clostridia	NT	Chemotaxis protein cheY	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
CMS1_k127_3257993_6	555079.Toce_1139	2.756e-40	160.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,42G4N@68295|Thermoanaerobacterales	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
CMS1_k127_3257993_8	1499684.CCNP01000020_gene2249	1.32e-37	148.0	COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,24JW7@186801|Clostridia,36I39@31979|Clostridiaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
CMS1_k127_3257993_4	689781.AUJX01000020_gene2554	6.901e-45	174.0	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,2PR55@265975|Oribacterium	186801|Clostridia	E	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
CMS1_k127_3257993_3	1336241.JAEB01000004_gene543	1.519e-48	181.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,25W10@186806|Eubacteriaceae	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
CMS1_k127_3257993_10	759362.KVU_0265	1.594e-08	59.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
CMS1_k127_3258153_0	32057.KB217478_gene1508	3.875e-37	164.0	COG1572@1|root,COG1572@2|Bacteria,1GE0K@1117|Cyanobacteria,1HRW1@1161|Nostocales	1117|Cyanobacteria	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS1_k127_3260073_1	1169144.KB910924_gene645	6.624e-67	234.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,1ZDBF@1386|Bacillus	91061|Bacilli	L	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS1_k127_3260073_2	1147.D082_08010	1.562e-55	210.0	COG2385@1|root,COG2385@2|Bacteria,1G2FP@1117|Cyanobacteria,1H4V4@1142|Synechocystis	1117|Cyanobacteria	D	Stage II sporulation protein	spoIID	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
CMS1_k127_3260073_0	351348.Maqu_1113	1.164e-96	327.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,464VM@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
CMS1_k127_3260073_3	272562.CA_C1303	9.632e-42	163.0	COG0327@1|root,COG0327@2|Bacteria,1TQ27@1239|Firmicutes,248Q2@186801|Clostridia,36E01@31979|Clostridiaceae	186801|Clostridia	S	dinuclear metal center protein, YbgI	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
CMS1_k127_3267455_1	1177181.T9A_02323	8.867e-75	272.0	COG1474@1|root,COG1474@2|Bacteria,1R9D0@1224|Proteobacteria,1RP8W@1236|Gammaproteobacteria,1XJX2@135619|Oceanospirillales	135619|Oceanospirillales	LO	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
CMS1_k127_3267455_0	1163617.SCD_n00275	1.358e-90	304.0	COG0668@1|root,COG0668@2|Bacteria,1QATN@1224|Proteobacteria	1224|Proteobacteria	M	COG0668 Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CMS1_k127_3272982_0	243231.GSU0474	1.89e-134	442.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43TNR@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_9,Response_reg
CMS1_k127_3272982_2	1033732.CAHI01000016_gene247	7.225e-05	51.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Glyco_hydro_cc,Sigma70_r2,Sigma70_r4_2
CMS1_k127_3272982_3	1283300.ATXB01000001_gene1440	0.0001224	53.0	COG1462@1|root,COG1462@2|Bacteria	2|Bacteria	M	curli production assembly transport component CsgG	csgG	-	-	-	-	-	-	-	-	-	-	-	CsgG,DUF4384,PG_binding_1
CMS1_k127_3272982_1	177437.HRM2_43980	7.478e-110	396.0	COG0840@1|root,COG0840@2|Bacteria,1N12X@1224|Proteobacteria,42UQY@68525|delta/epsilon subdivisions,2WPZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3276014_2	204536.SULAZ_1205	4.547e-54	197.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	prt	-	1.1.1.342	ko:K12453	ko00520,map00520	-	R04265	RC00154	ko00000,ko00001,ko01000	-	-	-	Epimerase
CMS1_k127_3276014_0	123214.PERMA_1995	1.184e-160	514.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	rfbG	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS1_k127_3276014_1	123214.PERMA_1993	5.521e-126	406.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
CMS1_k127_3280062_1	744872.Spica_1397	3.79e-67	240.0	COG1235@1|root,COG1235@2|Bacteria,2J5C5@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS1_k127_3280062_0	926561.KB900621_gene2861	5.737e-76	265.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,3WAGN@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
CMS1_k127_3280062_2	485913.Krac_5139	5.639e-16	85.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS1_k127_3290622_0	314345.SPV1_00095	1.227e-152	521.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria	1224|Proteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS1_k127_3290622_1	573413.Spirs_1898	2.654e-23	100.0	COG2331@1|root,COG2331@2|Bacteria,2J904@203691|Spirochaetes	203691|Spirochaetes	S	FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
CMS1_k127_3299219_1	1227352.C173_05811	0.0006569	53.0	COG5492@1|root,COG5492@2|Bacteria,1VAUC@1239|Firmicutes,4HN5U@91061|Bacilli,26SQP@186822|Paenibacillaceae	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Glug,SLH
CMS1_k127_3299219_0	397290.C810_04857	1.008e-09	69.0	COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,27KE2@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS1_k127_3301147_0	1444310.JANV01000096_gene3256	4.66e-64	231.0	COG2189@1|root,COG2189@2|Bacteria,1TR8A@1239|Firmicutes,4HSRS@91061|Bacilli,1ZQDQ@1386|Bacillus	91061|Bacilli	L	DNA methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
CMS1_k127_3313182_0	56107.Cylst_1519	1.55e-300	965.0	COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HJVE@1161|Nostocales	1117|Cyanobacteria	Q	COGs COG3321 Polyketide synthase modules and related protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS1_k127_3313182_1	388413.ALPR1_18478	1.452e-19	100.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Hepar_II_III,Hepar_II_III_N,OprD
CMS1_k127_3313713_7	1136163.M565_ctg5P0620	1.247e-13	76.0	COG0023@1|root,COG0023@2|Bacteria,1MZ8T@1224|Proteobacteria,1S929@1236|Gammaproteobacteria,1XXTP@135623|Vibrionales	135623|Vibrionales	J	COG0023 Translation initiation factor 1 (eIF-1 SUI1) and related proteins	yciH	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
CMS1_k127_3313713_3	696748.ASU2_04565	7.5e-46	177.0	COG0491@1|root,COG0491@2|Bacteria,1MY6G@1224|Proteobacteria,1RRBB@1236|Gammaproteobacteria,1Y9K7@135625|Pasteurellales	135625|Pasteurellales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_3313713_1	1196322.A370_00143	5.859e-91	304.0	COG0500@1|root,COG2226@2|Bacteria,1V3HT@1239|Firmicutes,24EY6@186801|Clostridia,36H88@31979|Clostridiaceae	186801|Clostridia	Q	SAM-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3313713_4	485916.Dtox_1860	4.416e-41	156.0	COG0826@1|root,COG0826@2|Bacteria,1VJN3@1239|Firmicutes,24TRY@186801|Clostridia,2652C@186807|Peptococcaceae	186801|Clostridia	O	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
CMS1_k127_3313713_5	1297581.H919_04734	1.609e-36	156.0	COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,4HBDM@91061|Bacilli,21VZU@150247|Anoxybacillus	91061|Bacilli	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
CMS1_k127_3313713_6	56780.SYN_01466	1.821e-15	91.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKG2@28221|Deltaproteobacteria,2MRAW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	ATPase family associated with various cellular activities (AAA)	flbD	-	-	ko:K10943	ko02020,ko05111,map02020,map05111	M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS1_k127_3313713_2	1304885.AUEY01000045_gene253	6.71e-84	304.0	COG0642@1|root,COG0834@1|root,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43BSB@68525|delta/epsilon subdivisions,2X735@28221|Deltaproteobacteria,2MPRY@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Bacterial periplasmic substrate-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SBP_bac_3
CMS1_k127_3313713_0	944480.ATUV01000002_gene78	1.779e-161	516.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria,2M6RF@213113|Desulfurellales	28221|Deltaproteobacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
CMS1_k127_3317971_1	1341155.FSS13T_07960	0.0001317	49.0	COG4412@1|root,COG4932@1|root,COG5184@1|root,COG4412@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,4NK5Z@976|Bacteroidetes,1IKKZ@117743|Flavobacteriia,2NTPP@237|Flavobacterium	976|Bacteroidetes	DMZ	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494
CMS1_k127_3317971_2	1002367.HMPREF0673_01513	0.0002477	48.0	2E4KV@1|root,32ZFU@2|Bacteria,4PN8Z@976|Bacteroidetes,2G0SF@200643|Bacteroidia	976|Bacteroidetes	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
CMS1_k127_3317971_0	744872.Spica_1067	5.922e-09	72.0	COG1196@1|root,COG3210@1|root,COG1196@2|Bacteria,COG3210@2|Bacteria,2J8QW@203691|Spirochaetes	203691|Spirochaetes	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3319318_4	944480.ATUV01000002_gene336	2.719e-10	68.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3,ATPgrasp_TupA,RimK
CMS1_k127_3319318_2	858215.Thexy_0300	8.461e-21	99.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,24JE8@186801|Clostridia,42G0X@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM UvrB UvrC protein	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
CMS1_k127_3319318_1	1384057.CD33_11485	3.335e-62	226.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,4HC6U@91061|Bacilli,3IXE8@400634|Lysinibacillus	91061|Bacilli	E	Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity	mcsB	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
CMS1_k127_3319318_0	635013.TherJR_0243	9.374e-255	810.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,26059@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
CMS1_k127_3319318_3	1227268.HMPREF1552_02066	2.22e-20	101.0	COG1762@1|root,COG1762@2|Bacteria,379WR@32066|Fusobacteria	32066|Fusobacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
CMS1_k127_3320821_0	665571.STHERM_c21600	0.0	1037.0	COG1274@1|root,COG1274@2|Bacteria,2J5BB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
CMS1_k127_3320821_2	1307761.L21SP2_2803	1.001e-167	535.0	COG1883@1|root,COG1883@2|Bacteria,2J61F@203691|Spirochaetes	203691|Spirochaetes	C	Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
CMS1_k127_3320821_1	1123274.KB899414_gene3625	7.401e-269	839.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J5JF@203691|Spirochaetes	203691|Spirochaetes	C	Oxaloacetate decarboxylase, alpha subunit	oadA	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
CMS1_k127_3320821_4	387093.SUN_1434	1.145e-05	50.0	COG3630@1|root,COG3630@2|Bacteria,1NFR4@1224|Proteobacteria,42XNE@68525|delta/epsilon subdivisions,2YQSS@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Oxaloacetate decarboxylase, gamma chain	oadG	-	4.1.1.3	ko:K01573	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_gamma
CMS1_k127_3320821_3	697303.Thewi_1937	1.478e-31	133.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,42F0N@68295|Thermoanaerobacterales	186801|Clostridia	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
CMS1_k127_3327083_7	237368.SCABRO_00078	2.904e-10	73.0	COG0664@1|root,COG1716@1|root,COG0664@2|Bacteria,COG1716@2|Bacteria,2J4FD@203682|Planctomycetes	203682|Planctomycetes	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
CMS1_k127_3327083_0	237368.SCABRO_03660	1.583e-129	434.0	COG3387@1|root,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	3.2.1.40	ko:K05989,ko:K20541	-	-	-	-	ko00000,ko01000,ko02000	4.D.3.1.6	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,fn3
CMS1_k127_3327083_8	1200557.JHWV01000001_gene629	3.546e-05	55.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H28A@909932|Negativicutes	909932|Negativicutes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
CMS1_k127_3327083_1	608506.COB47_1059	5.433e-55	199.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,42G7Y@68295|Thermoanaerobacterales	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
CMS1_k127_3327083_6	1410658.JHWI01000045_gene460	1.099e-15	81.0	2DIN5@1|root,303PR@2|Bacteria,1TV04@1239|Firmicutes,3VU74@526524|Erysipelotrichia	526524|Erysipelotrichia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3327083_3	332101.JIBU02000005_gene275	1.925e-27	121.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24BK7@186801|Clostridia,36EP7@31979|Clostridiaceae	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
CMS1_k127_3327083_4	1480694.DC28_02700	1.531e-26	119.0	2EY48@1|root,33RD4@2|Bacteria,2J65N@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
CMS1_k127_3327083_2	573413.Spirs_2587	2.866e-29	127.0	2EY48@1|root,33UVP@2|Bacteria,2J5KT@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar filament outer layer protein FlaA	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
CMS1_k127_3327083_5	1123274.KB899421_gene1771	9.805e-21	97.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,2J5MW@203691|Spirochaetes	203691|Spirochaetes	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
CMS1_k127_3327471_2	293826.Amet_2695	7.366e-39	150.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia,36I61@31979|Clostridiaceae	186801|Clostridia	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
CMS1_k127_3327471_1	747365.Thena_0029	4.781e-50	188.0	COG1639@1|root,COG1639@2|Bacteria,1TPRT@1239|Firmicutes,249CG@186801|Clostridia,42IUS@68295|Thermoanaerobacterales	186801|Clostridia	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
CMS1_k127_3327471_0	706587.Desti_3051	7.771e-138	448.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria,2MQ3U@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	aminotransferase, class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_3327471_3	477228.YO5_03572	0.0007658	47.0	2DSPU@1|root,33GZC@2|Bacteria,1NJ5W@1224|Proteobacteria,1SHAK@1236|Gammaproteobacteria,1YZXG@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
CMS1_k127_3328227_0	373994.Riv7116_0585	2.849e-48	184.0	COG2234@1|root,COG2234@2|Bacteria,1G1QW@1117|Cyanobacteria,1HRDH@1161|Nostocales	1117|Cyanobacteria	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
CMS1_k127_3328227_1	1535422.ND16A_1005	8.926e-18	94.0	COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,2Q5Y8@267889|Colwelliaceae	1236|Gammaproteobacteria	D	Lysin motif	nlpD	GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
CMS1_k127_3328686_0	2325.TKV_c05880	8.792e-178	583.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,42EUR@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
CMS1_k127_3328686_3	1499967.BAYZ01000103_gene3779	7.004e-07	55.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
CMS1_k127_3328686_1	926561.KB900623_gene1093	1.381e-109	378.0	COG1199@1|root,COG1199@2|Bacteria,1TQHQ@1239|Firmicutes,25C6H@186801|Clostridia,3WAEQ@53433|Halanaerobiales	186801|Clostridia	L	TIGRFAM DnaQ family exonuclease DinG family helicase	dinG	-	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,RNase_T,RadC,ResIII
CMS1_k127_3328686_2	1122939.ATUD01000004_gene3865	4.524e-08	66.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4CU6Q@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
CMS1_k127_3332106_0	1291050.JAGE01000002_gene3559	2.302e-232	744.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes	1239|Firmicutes	Q	synthase	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS1_k127_3332196_0	331678.Cphamn1_0072	3.598e-214	687.0	COG0514@1|root,COG0514@2|Bacteria,1FDF2@1090|Chlorobi	1090|Chlorobi	L	DEAD DEAH box helicase domain protein	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
CMS1_k127_3332631_0	760142.Hipma_1696	1.075e-72	257.0	COG0297@1|root,COG0297@2|Bacteria,1RB6U@1224|Proteobacteria	1224|Proteobacteria	G	Glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS1_k127_3333275_0	759914.BP951000_1820	8.431e-254	817.0	COG0841@1|root,COG0841@2|Bacteria,2J9MF@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS1_k127_3333275_3	1345695.CLSA_c38110	2.535e-54	200.0	COG1418@1|root,COG1418@2|Bacteria,1UIP0@1239|Firmicutes,25EPQ@186801|Clostridia,36UT2@31979|Clostridiaceae	186801|Clostridia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS1_k127_3333275_2	547045.NEISICOT_02945	1.774e-55	203.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,2KPUH@206351|Neisseriales	206351|Neisseriales	L	hydrolase, TatD family	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
CMS1_k127_3333275_1	1519464.HY22_10540	1.253e-185	596.0	COG0029@1|root,COG0029@2|Bacteria,1FD79@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
CMS1_k127_3333275_4	316067.Geob_1358	3.543e-16	85.0	COG4900@1|root,COG4900@2|Bacteria,1NQAA@1224|Proteobacteria,42X8V@68525|delta/epsilon subdivisions,2WT0I@28221|Deltaproteobacteria,43V8W@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3333705_0	237368.SCABRO_02639	3.503e-176	567.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2IYK8@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
CMS1_k127_3333705_3	309799.DICTH_1465	7.871e-107	355.0	COG0540@1|root,COG0540@2|Bacteria	2|Bacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15490	OTCace,OTCace_N
CMS1_k127_3333705_1	398767.Glov_2084	1.018e-131	432.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,43TM6@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
CMS1_k127_3333705_4	177437.HRM2_31940	2.225e-38	152.0	COG2091@1|root,COG2091@2|Bacteria,1N2UP@1224|Proteobacteria,42UF1@68525|delta/epsilon subdivisions,2WQ9G@28221|Deltaproteobacteria,2MKMH@213118|Desulfobacterales	28221|Deltaproteobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ACPS
CMS1_k127_3333705_6	411490.ANACAC_00275	1.81e-05	58.0	COG0768@1|root,COG0768@2|Bacteria,1TPER@1239|Firmicutes,2486R@186801|Clostridia	186801|Clostridia	M	Penicillin-binding Protein	pbpA2	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
CMS1_k127_3333705_5	1242864.D187_008155	8.945e-14	85.0	COG0768@1|root,COG2385@1|root,COG0768@2|Bacteria,COG2385@2|Bacteria,1RGJS@1224|Proteobacteria,42RZE@68525|delta/epsilon subdivisions,2WNH8@28221|Deltaproteobacteria	1224|Proteobacteria	D	Stage II sporulation D domain protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID,TPR_6,TPR_8
CMS1_k127_3333705_2	321332.CYB_2140	1.573e-125	454.0	COG2373@1|root,COG2373@2|Bacteria,1G1A1@1117|Cyanobacteria,1H0M9@1129|Synechococcus	1117|Cyanobacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,CarboxypepD_reg,MG1,Thiol-ester_cl
CMS1_k127_3345752_7	1232437.KL661988_gene199	1.783e-47	181.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,42M2V@68525|delta/epsilon subdivisions,2WKEB@28221|Deltaproteobacteria,2MISW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Putative RNA methylase family UPF0020	-	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
CMS1_k127_3345752_4	69014.TK2135	4.684e-74	263.0	COG2265@1|root,arCOG00122@2157|Archaea,2Y2CR@28890|Euryarchaeota,243DC@183968|Thermococci	183968|Thermococci	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.35	ko:K00557	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_U5-meth_tr
CMS1_k127_3345752_6	573061.Clocel_4085	3.985e-49	183.0	COG1309@1|root,COG1309@2|Bacteria,1V5H6@1239|Firmicutes,24ITS@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
CMS1_k127_3345752_1	926561.KB900621_gene2822	3.345e-159	514.0	COG0366@1|root,COG0366@2|Bacteria,1TQFJ@1239|Firmicutes,249Y3@186801|Clostridia	186801|Clostridia	G	Alpha amylase, catalytic domain protein	-	-	3.2.1.133,3.2.1.135,3.2.1.54,3.5.4.33	ko:K01208,ko:K11991	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R10223,R11262	RC00477	ko00000,ko00001,ko01000,ko03016	-	GH13	-	Alpha-amylase,Alpha-amylase_C,DUF1653,Malt_amylase_C
CMS1_k127_3345752_2	926561.KB900617_gene1427	5.05e-90	307.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_3345752_0	1304885.AUEY01000008_gene2095	4.512e-234	738.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,2MKEW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
CMS1_k127_3345752_8	997884.HMPREF1068_02444	2.907e-36	145.0	COG4642@1|root,COG4642@2|Bacteria,4NJPY@976|Bacteroidetes,2FMDX@200643|Bacteroidia,4AMBW@815|Bacteroidaceae	976|Bacteroidetes	S	phosphatidylinositol-4-phosphate 5-kinase family protein K00889	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	MORN
CMS1_k127_3345752_3	289376.THEYE_A0373	4.273e-78	285.0	COG2984@1|root,COG3829@1|root,COG4585@1|root,COG2984@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,3J12P@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA_3,PAS_9
CMS1_k127_3345752_5	395493.BegalDRAFT_1112	4.163e-60	217.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T4BF@1236|Gammaproteobacteria	1224|Proteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	chiS	-	2.7.13.3	ko:K07711,ko:K19694	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HTH_18,HisKA,PAS,PAS_3,PAS_4,PAS_8,Response_reg,Y_Y_Y
CMS1_k127_3348064_0	452471.Aasi_1435	2.116e-09	69.0	COG0666@1|root,COG1196@1|root,COG0666@2|Bacteria,COG1196@2|Bacteria,4NEYY@976|Bacteroidetes,47MVD@768503|Cytophagia	976|Bacteroidetes	U	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,SHOCT,SecA_DEAD
CMS1_k127_3361056_3	272563.CD630_29650	2.256e-07	64.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia	186801|Clostridia	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,dCache_1
CMS1_k127_3361056_2	367737.Abu_0867	7.863e-09	62.0	COG2236@1|root,COG2236@2|Bacteria,1Q1HY@1224|Proteobacteria,42TR4@68525|delta/epsilon subdivisions,2YP9B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	phosphoribosyltransferase	gpt	-	2.4.2.22	ko:K00769	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
CMS1_k127_3361056_0	944547.ABLL_1071	5.294e-154	497.0	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2YM94@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
CMS1_k127_3361056_1	1273538.G159_07015	2.412e-13	77.0	COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,4HB06@91061|Bacilli,26EBY@186818|Planococcaceae	91061|Bacilli	M	enzyme of poly-gamma-glutamate biosynthesis (capsule formation)	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS1_k127_3381575_1	1121875.KB907547_gene2908	2.947e-53	201.0	COG0834@1|root,COG2172@1|root,COG2208@1|root,COG3829@1|root,COG0834@2|Bacteria,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3829@2|Bacteria,4PPGD@976|Bacteroidetes	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3381575_2	265729.GS18_0221370	3.498e-12	79.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,4HC85@91061|Bacilli,1ZC6P@1386|Bacillus	91061|Bacilli	M	plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K01802,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,Trigger_C
CMS1_k127_3381575_0	1189612.A33Q_2076	1.687e-55	207.0	COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,47PIS@768503|Cytophagia	976|Bacteroidetes	M	Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CMS1_k127_3385655_4	243090.RB154	0.0007393	51.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Cadherin,DUF11,DUF4347,DUF5122,He_PIG,Laminin_G_3,SBBP
CMS1_k127_3385655_3	1086011.HJ01_00269	3.207e-05	54.0	COG0454@1|root,COG0456@2|Bacteria,4NTKC@976|Bacteroidetes,1I4J5@117743|Flavobacteriia,2NYGF@237|Flavobacterium	976|Bacteroidetes	K	FR47-like protein	-	-	2.3.1.210	ko:K16704	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS1_k127_3385655_1	1033743.CAES01000007_gene2009	6.598e-102	337.0	COG0106@1|root,COG0106@2|Bacteria,1TPIN@1239|Firmicutes,4HDNE@91061|Bacilli,26SIM@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS1_k127_3385655_2	1392498.JQLH01000001_gene1415	9.386e-50	191.0	COG2035@1|root,COG2035@2|Bacteria,4NFKI@976|Bacteroidetes,1HYAC@117743|Flavobacteriia,2PGPI@252356|Maribacter	976|Bacteroidetes	S	Domain of unknown function (DUF368)	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
CMS1_k127_3385655_0	1131269.AQVV01000017_gene1969	3.341e-247	784.0	COG0458@1|root,COG1304@1|root,COG0458@2|Bacteria,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	lldD	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4,FMN_dh
CMS1_k127_3391707_0	717231.Flexsi_2050	5.887e-132	430.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
CMS1_k127_3391707_1	1071073.KI530546_gene2774	9.103e-43	178.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,1ZBEA@1386|Bacillus	91061|Bacilli	NT	chemotaxis protein	mcpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
CMS1_k127_3391707_2	44454.NF84_06030	1.622e-10	72.0	COG0463@1|root,COG0463@2|Bacteria,2I2NK@201174|Actinobacteria,232KP@1762|Mycobacteriaceae	201174|Actinobacteria	M	glucosyl-3-phosphoglycerate synthase	gpgS	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006011,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009225,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0034641,GO:0040007,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046983,GO:0055086,GO:0071704,GO:1901135,GO:1901360	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2
CMS1_k127_3391707_4	1408473.JHXO01000009_gene3404	9.917e-09	64.0	COG1615@1|root,COG1615@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
CMS1_k127_3395369_0	207954.MED92_06473	3.729e-19	94.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XIWS@135619|Oceanospirillales	135619|Oceanospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS1_k127_3395369_1	944479.JQLX01000013_gene1438	1.615e-06	60.0	COG4254@1|root,COG4254@2|Bacteria,1NATC@1224|Proteobacteria,42X7Q@68525|delta/epsilon subdivisions,2WS9F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS1_k127_3395646_1	1121422.AUMW01000003_gene971	4.455e-62	225.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,2675R@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	xerD	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS1_k127_3395646_0	941824.TCEL_01845	1.056e-234	746.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,36DSI@31979|Clostridiaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
CMS1_k127_3395646_2	580327.Tthe_1463	8.917e-53	200.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,42FQZ@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
CMS1_k127_3395646_3	1125701.HMPREF1221_00624	6.132e-11	72.0	COG0457@1|root,COG0457@2|Bacteria,2J7BD@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
CMS1_k127_3396916_0	909663.KI867149_gene3196	5.947e-109	363.0	COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,42M6U@68525|delta/epsilon subdivisions,2WJ6Y@28221|Deltaproteobacteria,2MQAW@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
CMS1_k127_3396916_2	1349785.BAUG01000056_gene2477	1.644e-42	164.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,1HX52@117743|Flavobacteriia	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
CMS1_k127_3396916_1	926561.KB900617_gene1427	3.316e-89	304.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
CMS1_k127_3396916_3	521045.Kole_0186	0.0004132	44.0	COG0366@1|root,COG0366@2|Bacteria,2GBYH@200918|Thermotogae	200918|Thermotogae	G	PFAM alpha amylase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Malt_amylase_C
CMS1_k127_339725_0	526224.Bmur_2454	5.742e-102	339.0	COG1149@1|root,COG1149@2|Bacteria,2JBH1@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S dicluster domain	fdx	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS1_k127_339725_1	1480694.DC28_14035	1.1e-35	144.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	nnrR	-	-	ko:K01420,ko:K21564	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_339725_2	526224.Bmur_1972	5.152e-14	77.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS1_k127_3400203_5	1195236.CTER_1490	8.786e-32	141.0	COG3177@1|root,COG3179@1|root,COG3177@2|Bacteria,COG3179@2|Bacteria,1VAED@1239|Firmicutes,24MPQ@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	AHH,DUF4157,LysM
CMS1_k127_3400203_1	1230342.CTM_11233	1.231e-91	309.0	COG4667@1|root,COG4667@2|Bacteria,1TQ9W@1239|Firmicutes,2485C@186801|Clostridia,36FP3@31979|Clostridiaceae	186801|Clostridia	S	Phospholipase, patatin family	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
CMS1_k127_3400203_0	118161.KB235920_gene5993	6.67e-164	541.0	COG0464@1|root,COG0464@2|Bacteria,1G1YA@1117|Cyanobacteria,3VNFJ@52604|Pleurocapsales	1117|Cyanobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS1_k127_3400203_6	1410616.JHXE01000022_gene2233	9.238e-16	92.0	294SJ@1|root,2ZS5U@2|Bacteria,1VMUJ@1239|Firmicutes,24WT3@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3400203_3	502025.Hoch_0871	1.26e-64	247.0	COG3103@1|root,COG5412@1|root,COG3103@2|Bacteria,COG5412@2|Bacteria,1Q3H5@1224|Proteobacteria,4399N@68525|delta/epsilon subdivisions,2X4H2@28221|Deltaproteobacteria,2YZ02@29|Myxococcales	28221|Deltaproteobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
CMS1_k127_3400203_4	927677.ALVU02000001_gene2790	6.047e-38	146.0	COG3613@1|root,COG3613@2|Bacteria,1GAKE@1117|Cyanobacteria	1117|Cyanobacteria	F	Nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
CMS1_k127_3400203_2	335543.Sfum_1962	1.04e-80	275.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42QUN@68525|delta/epsilon subdivisions,2WN6Q@28221|Deltaproteobacteria,2MRR2@213462|Syntrophobacterales	28221|Deltaproteobacteria	OU	TIGRFAM signal peptide peptidase SppA, 36K type	sppA2	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
CMS1_k127_3402787_3	289376.THEYE_A1494	1.345e-54	204.0	COG1234@1|root,COG1234@2|Bacteria,3J113@40117|Nitrospirae	40117|Nitrospirae	S	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	-
CMS1_k127_3402787_1	56780.SYN_00664	3.963e-171	554.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Pyridoxal-dependent decarboxylase	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	EF-hand_7,Pyridoxal_deC
CMS1_k127_3402787_0	1232437.KL662020_gene757	1.556e-186	591.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MI6F@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_3402787_5	1195236.CTER_4341	3.548e-24	105.0	2C1T4@1|root,336EA@2|Bacteria,1VVT5@1239|Firmicutes,24J1U@186801|Clostridia,3WPVT@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3402787_2	572544.Ilyop_0916	3.532e-111	371.0	COG1454@1|root,COG1454@2|Bacteria,3792I@32066|Fusobacteria	32066|Fusobacteria	C	PFAM Iron-containing alcohol dehydrogenase	fucO	-	1.1.1.77	ko:K00048	ko00630,ko00640,ko01120,map00630,map00640,map01120	-	R01781,R02257	RC00087,RC00099	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS1_k127_3402787_4	1122947.FR7_1072	6.036e-33	130.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	lsrG	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
CMS1_k127_3403481_5	909663.KI867150_gene132	2.861e-108	374.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJ30@28221|Deltaproteobacteria,2MQZ8@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	UvrD/REP helicase N-terminal domain	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
CMS1_k127_3403481_2	1121405.dsmv_0171	1.832e-122	415.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42NRK@68525|delta/epsilon subdivisions,2WIM6@28221|Deltaproteobacteria,2MI96@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
CMS1_k127_3403481_4	889378.Spiaf_0775	2.016e-112	379.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
CMS1_k127_3403481_11	1009370.ALO_00500	2.303e-23	113.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	ko:K06141	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1
CMS1_k127_3403481_10	1321778.HMPREF1982_04107	2.17e-58	212.0	COG1378@1|root,COG1378@2|Bacteria	2|Bacteria	K	Sugar-specific transcriptional regulator TrmB	yrhO1	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
CMS1_k127_3403481_0	1303518.CCALI_00158	1.738e-237	745.0	COG0166@1|root,COG0166@2|Bacteria	2|Bacteria	G	Belongs to the GPI family	pgi	GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcSMS35_1347.EcSMS35_4486	PGI
CMS1_k127_3403481_12	880073.Calab_3468	2.363e-10	68.0	28RHF@1|root,2ZDWF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3403481_9	573413.Spirs_3041	5.381e-64	235.0	COG1418@1|root,COG4905@1|root,COG1418@2|Bacteria,COG4905@2|Bacteria,2J7SH@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG4905 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
CMS1_k127_3403481_7	909663.KI867150_gene1442	7.335e-83	287.0	COG0682@1|root,COG0682@2|Bacteria,1NB9I@1224|Proteobacteria,42M7E@68525|delta/epsilon subdivisions,2WJU5@28221|Deltaproteobacteria,2MQYV@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Prolipoprotein diacylglyceryl transferase	-	-	-	-	-	-	-	-	-	-	-	-	LGT
CMS1_k127_3403481_3	269799.Gmet_1483	2.752e-122	401.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,42PAW@68525|delta/epsilon subdivisions,2WJV9@28221|Deltaproteobacteria,43TFP@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Belongs to the phosphatidylserine decarboxylase family	-	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
CMS1_k127_3403481_1	404380.Gbem_1868	1.24e-231	741.0	COG2301@1|root,COG2301@2|Bacteria,1NAM2@1224|Proteobacteria,42P8P@68525|delta/epsilon subdivisions,2WJIP@28221|Deltaproteobacteria,43TWC@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3403481_8	1408473.JHXO01000013_gene548	2.173e-74	258.0	2A5H9@1|root,30U7G@2|Bacteria,4NPEP@976|Bacteroidetes,2FXPZ@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3403481_6	1321778.HMPREF1982_02748	4.267e-107	363.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,2686Y@186813|unclassified Clostridiales	186801|Clostridia	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_340459_0	1167006.UWK_01394	7.881e-51	199.0	COG2204@1|root,COG2461@1|root,COG3275@1|root,COG4191@1|root,COG2204@2|Bacteria,COG2461@2|Bacteria,COG3275@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ29@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,dCache_3
CMS1_k127_3407307_4	1410609.JHVB01000007_gene980	4.441e-16	90.0	2EW9A@1|root,33PN0@2|Bacteria,2J6QJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS1_k127_3407307_0	293826.Amet_1426	3.551e-109	359.0	COG2720@1|root,COG2720@2|Bacteria,1TQM8@1239|Firmicutes,24AE8@186801|Clostridia,36HTW@31979|Clostridiaceae	186801|Clostridia	V	VanW like protein	-	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	VanW
CMS1_k127_3407307_2	760192.Halhy_2324	3.511e-38	145.0	COG3549@1|root,COG3549@2|Bacteria,4NSZ2@976|Bacteroidetes,1J14E@117747|Sphingobacteriia	976|Bacteroidetes	S	COG3549 Plasmid maintenance system killer protein	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
CMS1_k127_3407307_1	865937.Gilli_1209	3.154e-38	145.0	COG3093@1|root,COG3093@2|Bacteria,4NSBZ@976|Bacteroidetes,1I3BH@117743|Flavobacteriia,2P7JV@244698|Gillisia	976|Bacteroidetes	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
CMS1_k127_3407307_3	1120978.KB894079_gene566	7.517e-27	114.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,27FKE@186828|Carnobacteriaceae	91061|Bacilli	L	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS1_k127_3409367_0	316067.Geob_0785	5.697e-138	449.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
CMS1_k127_3409367_1	1121430.JMLG01000003_gene610	3.915e-131	430.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,260UE@186807|Peptococcaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
CMS1_k127_3409367_2	880073.Calab_1221	4.653e-10	70.0	COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria	2|Bacteria	KT	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ,Response_reg
CMS1_k127_3451313_3	1408473.JHXO01000004_gene37	2.03e-61	215.0	COG0692@1|root,COG0692@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	ung	GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS1_k127_3451313_1	941824.TCEL_01548	7.123e-78	265.0	COG2129@1|root,COG2129@2|Bacteria,1V0W0@1239|Firmicutes,24A73@186801|Clostridia,36I2R@31979|Clostridiaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
CMS1_k127_3451313_0	1321778.HMPREF1982_02225	3.173e-221	704.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia,268EB@186813|unclassified Clostridiales	186801|Clostridia	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	-	-	-	-	-	-	-	-	-	Bmp
CMS1_k127_3451313_2	485915.Dret_1194	1.981e-72	255.0	COG0679@1|root,COG0679@2|Bacteria,1RAR6@1224|Proteobacteria,42R7S@68525|delta/epsilon subdivisions,2WN3D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
CMS1_k127_3451313_4	28115.HR11_08915	1.497e-10	73.0	COG1629@1|root,COG4771@2|Bacteria,4NE4M@976|Bacteroidetes,2FNUY@200643|Bacteroidia,22VV4@171551|Porphyromonadaceae	976|Bacteroidetes	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
CMS1_k127_345670_0	1045858.Bint_1685	7.103e-85	295.0	COG2885@1|root,COG2885@2|Bacteria,2J6IG@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	tpn50	-	-	-	-	-	-	-	-	-	-	-	OmpA
CMS1_k127_345670_1	1410653.JHVC01000013_gene3649	1.169e-71	248.0	COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,248GA@186801|Clostridia,36ETT@31979|Clostridiaceae	186801|Clostridia	G	2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase	eda	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
CMS1_k127_345999_2	1358423.N180_01765	6.998e-09	61.0	COG1848@1|root,COG1848@2|Bacteria,4P6F4@976|Bacteroidetes	976|Bacteroidetes	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
CMS1_k127_345999_1	247490.KSU1_B0337	3.238e-29	120.0	arCOG05255@1|root,33EBU@2|Bacteria	2|Bacteria	S	STAS-like domain of unknown function (DUF4325)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4325
CMS1_k127_345999_0	525898.Sdel_1500	1.273e-69	246.0	COG0642@1|root,COG0642@2|Bacteria,1NKPQ@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_346090_6	180332.JTGN01000011_gene606	0.0001734	48.0	COG1682@1|root,COG1682@2|Bacteria,1TQZF@1239|Firmicutes,248R0@186801|Clostridia	186801|Clostridia	GM	Transport permease protein	-	-	-	ko:K09692	ko02010,map02010	M00251	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.104	-	-	ABC2_membrane
CMS1_k127_346090_2	537972.ABQU01000028_gene511	3.371e-123	403.0	COG0673@1|root,COG0673@2|Bacteria,1NKUI@1224|Proteobacteria	1224|Proteobacteria	S	oxidoreductase()	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_346090_4	537972.ABQU01000028_gene512	6.643e-65	226.0	COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,43AR0@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	SIS domain	gmhA	-	5.3.1.28	ko:K03271,ko:K12961	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005,ko03036	-	-	-	SIS_2
CMS1_k127_346090_5	1353529.M899_1432	3.554e-08	64.0	COG2227@1|root,COG2227@2|Bacteria,1RDQY@1224|Proteobacteria,42U2C@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS1_k127_346090_1	439235.Dalk_2506	2.072e-190	600.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MHVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
CMS1_k127_346090_3	583355.Caka_1109	7.119e-106	353.0	COG0524@1|root,COG0524@2|Bacteria,46W0T@74201|Verrucomicrobia,3K79H@414999|Opitutae	414999|Opitutae	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS1_k127_346090_0	2340.JV46_16530	1.692e-227	711.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1J8WH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	iYL1228.KPN_02462	AdoHcyase,AdoHcyase_NAD
CMS1_k127_3462226_3	9778.XP_004378349.1	9.427e-23	110.0	COG0666@1|root,KOG0504@2759|Eukaryota,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BXXJ@33208|Metazoa,3E5E3@33213|Bilateria,4835M@7711|Chordata,492MV@7742|Vertebrata,3J25E@40674|Mammalia,350HH@311790|Afrotheria	33208|Metazoa	M	Serine threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B	ANKRD44	-	-	ko:K15502,ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
CMS1_k127_3462226_0	59374.Fisuc_2032	4.246e-128	416.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
CMS1_k127_3462226_1	1288963.ADIS_2793	4.192e-52	190.0	COG0800@1|root,COG0800@2|Bacteria,4NHVV@976|Bacteroidetes,47MP6@768503|Cytophagia	976|Bacteroidetes	G	KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
CMS1_k127_3462226_2	1355368.JART01000012_gene435	7.208e-23	107.0	COG2207@1|root,COG2207@2|Bacteria,1R6WN@1224|Proteobacteria,42SYR@68525|delta/epsilon subdivisions,2YPHG@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS1_k127_3466822_2	1121403.AUCV01000067_gene2184	1.604e-24	108.0	COG4902@1|root,COG4902@2|Bacteria,1N5X3@1224|Proteobacteria,42TKU@68525|delta/epsilon subdivisions,2WQUZ@28221|Deltaproteobacteria,2MKSQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Possible catecholamine-binding domain present in a variety of eukaryotic proteins.	-	-	-	-	-	-	-	-	-	-	-	-	DOMON
CMS1_k127_3466822_1	761193.Runsl_0383	7.235e-34	134.0	COG2315@1|root,COG2315@2|Bacteria,4NS6J@976|Bacteroidetes,47R6I@768503|Cytophagia	976|Bacteroidetes	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
CMS1_k127_3466822_0	1132509.C447_02642	7.735e-98	353.0	COG0553@1|root,arCOG00871@2157|Archaea,2XTQ1@28890|Euryarchaeota,23SWF@183963|Halobacteria	183963|Halobacteria	L	COG0553 Superfamily II DNA RNA helicases, SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
CMS1_k127_3466822_5	246197.MXAN_3788	0.0002876	48.0	COG3215@1|root,COG3215@2|Bacteria,1NW7J@1224|Proteobacteria,43C0W@68525|delta/epsilon subdivisions,2WVFV@28221|Deltaproteobacteria,2Z11R@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
CMS1_k127_3466822_3	596324.TREVI0001_0130	8.139e-13	75.0	2FBAD@1|root,343GE@2|Bacteria,2J7WU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3466822_4	118005.AWNK01000007_gene756	1.344e-10	72.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	LysM,TPR_16,TPR_6,YfiO
CMS1_k127_3467819_1	1121904.ARBP01000002_gene7103	9.983e-38	155.0	COG3391@1|root,COG3391@2|Bacteria,4NNWU@976|Bacteroidetes	976|Bacteroidetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3467819_2	635013.TherJR_0664	1.485e-33	133.0	COG2703@1|root,COG2703@2|Bacteria,1VBEC@1239|Firmicutes,24NV2@186801|Clostridia,263CR@186807|Peptococcaceae	186801|Clostridia	P	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
CMS1_k127_3467819_0	596323.HMPREF0554_0707	8.509e-70	258.0	COG1674@1|root,COG1674@2|Bacteria,379AG@32066|Fusobacteria	32066|Fusobacteria	D	Belongs to the FtsK SpoIIIE SftA family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Ftsk_gamma
CMS1_k127_3469769_1	1417230.AYOT01000223_gene871	3.367e-21	99.0	COG0586@1|root,COG0586@2|Bacteria,2J7GQ@203691|Spirochaetes	203691|Spirochaetes	S	SNARE associated Golgi protein	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
CMS1_k127_3469769_0	1131269.AQVV01000025_gene2327	3.164e-44	175.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,HTH_31
CMS1_k127_3469769_2	875454.BAEW01000001_gene114	0.0004131	51.0	COG0642@1|root,COG2205@2|Bacteria,1TR7T@1239|Firmicutes,24CJ8@186801|Clostridia	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS1_k127_3470889_0	1121904.ARBP01000032_gene2006	1.573e-132	436.0	COG0507@1|root,COG1112@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,4NK1G@976|Bacteroidetes,47RDC@768503|Cytophagia	976|Bacteroidetes	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF2726
CMS1_k127_3470889_1	1168289.AJKI01000002_gene2352	1.608e-18	91.0	COG4915@1|root,COG4915@2|Bacteria	2|Bacteria	S	5-bromo-4-chloroindolyl phosphate hydrolysis protein	xpaC	-	-	-	-	-	-	-	-	-	-	-	Halogen_Hydrol
CMS1_k127_3472726_1	1089553.Tph_c11100	1.333e-06	49.0	COG1191@1|root,COG1191@2|Bacteria,1TP9K@1239|Firmicutes,248M0@186801|Clostridia,42GJB@68295|Thermoanaerobacterales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS1_k127_3472726_0	573413.Spirs_1587	1.148e-116	399.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
CMS1_k127_3478967_1	1211814.CAPG01000083_gene3875	1.977e-56	201.0	2APNN@1|root,31ES7@2|Bacteria,1V7W5@1239|Firmicutes,4HJDN@91061|Bacilli,1ZFWC@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3478967_0	1499967.BAYZ01000187_gene3878	2.021e-206	655.0	COG1032@1|root,COG1032@2|Bacteria,2NNX6@2323|unclassified Bacteria	2|Bacteria	C	Radical SAM N-terminal	ygiQ	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
CMS1_k127_3481912_2	237368.SCABRO_01102	4.451e-28	120.0	COG0835@1|root,COG0835@2|Bacteria,2J076@203682|Planctomycetes	203682|Planctomycetes	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS1_k127_3481912_1	933262.AXAM01000059_gene2904	7.559e-99	349.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2MIVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
CMS1_k127_3481912_0	443143.GM18_1421	7.336e-146	469.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,43S6W@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB34H	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
CMS1_k127_3481912_3	582744.Msip34_2710	1.064e-24	109.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,2VRAI@28216|Betaproteobacteria,2KNRW@206350|Nitrosomonadales	206350|Nitrosomonadales	NT	SMART CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS1_k127_3481912_5	1209072.ALBT01000046_gene2553	4.314e-05	50.0	COG1366@1|root,COG1366@2|Bacteria,1N8B6@1224|Proteobacteria,1TC13@1236|Gammaproteobacteria,1FHQQ@10|Cellvibrio	1236|Gammaproteobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS
CMS1_k127_3481912_4	580332.Slit_1588	1.001e-23	105.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,44W69@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Signal transducing histidine kinase homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
CMS1_k127_3483360_5	66692.ABC1217	4.259e-09	62.0	COG1476@1|root,COG1476@2|Bacteria,1VEKB@1239|Firmicutes,4HM6U@91061|Bacilli	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,PTS_IIB,TM2
CMS1_k127_3483360_3	1028803.GG9_1419	1.012e-19	90.0	COG0759@1|root,COG0759@2|Bacteria,1QKA6@1224|Proteobacteria,1TIDP@1236|Gammaproteobacteria,1YAFC@135625|Pasteurellales	135625|Pasteurellales	S	Haemolytic	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
CMS1_k127_3483360_4	525146.Ddes_0229	2.325e-13	72.0	2E5QH@1|root,33ND6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
CMS1_k127_3483360_0	1507.HMPREF0262_02043	1.591e-91	306.0	COG0461@1|root,COG0461@2|Bacteria,1TREW@1239|Firmicutes,248WM@186801|Clostridia,36ETX@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
CMS1_k127_3483360_2	688269.Theth_1846	3.021e-45	176.0	COG3234@1|root,COG3234@2|Bacteria,2GDD4@200918|Thermotogae	200918|Thermotogae	S	Protein of unknown function (DUF1175)	-	-	-	ko:K09934	-	-	-	-	ko00000	-	-	-	DUF1175
CMS1_k127_3483360_1	580327.Tthe_0241	6.172e-76	269.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,42F14@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
CMS1_k127_3483360_6	1202532.FF52_00365	1.784e-06	58.0	COG0664@1|root,COG0664@2|Bacteria,4NKTI@976|Bacteroidetes,1HZ03@117743|Flavobacteriia,2P0GN@237|Flavobacterium	976|Bacteroidetes	T	CRP FNR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
CMS1_k127_3483714_2	234267.Acid_6710	4.486e-35	139.0	COG0782@1|root,COG0782@2|Bacteria,3Y49X@57723|Acidobacteria	57723|Acidobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
CMS1_k127_3483714_0	431943.CKL_3815	3.554e-146	473.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,36DKE@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
CMS1_k127_3483714_1	889378.Spiaf_1449	6.245e-96	330.0	COG0457@1|root,COG0457@2|Bacteria,2J5PC@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
CMS1_k127_3484005_8	580331.Thit_1231	1.019e-05	53.0	COG2882@1|root,COG2882@2|Bacteria,1VHRK@1239|Firmicutes,24UCS@186801|Clostridia,42H95@68295|Thermoanaerobacterales	186801|Clostridia	N	TIGRFAM flagellar export	fliJ	-	-	ko:K02413	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliJ
CMS1_k127_3484005_1	1408422.JHYF01000001_gene2978	1.303e-163	527.0	COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,25E6B@186801|Clostridia,36FF4@31979|Clostridiaceae	186801|Clostridia	NU	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412,ko:K03224	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
CMS1_k127_3484005_4	754027.HMPREF9554_00215	1.739e-49	188.0	COG1317@1|root,COG1317@2|Bacteria,2J5KZ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
CMS1_k127_3484005_0	665571.STHERM_c09110	3.503e-168	533.0	COG1536@1|root,COG1536@2|Bacteria,2J5CI@203691|Spirochaetes	203691|Spirochaetes	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
CMS1_k127_3484005_2	889378.Spiaf_2105	2.805e-97	339.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
CMS1_k127_3484005_7	1123274.KB899413_gene856	1.255e-11	69.0	COG1677@1|root,COG1677@2|Bacteria,2J8B3@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-basal body complex protein	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
CMS1_k127_3484005_3	290434.BG0296	1.318e-55	198.0	COG1558@1|root,COG1558@2|Bacteria,2J7Q7@203691|Spirochaetes	203691|Spirochaetes	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
CMS1_k127_3484005_6	889378.Spiaf_2108	1.074e-26	114.0	COG1815@1|root,COG1815@2|Bacteria,2J804@203691|Spirochaetes	203691|Spirochaetes	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
CMS1_k127_3484005_5	1121935.AQXX01000142_gene2220	1.161e-41	164.0	COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,1XI6K@135619|Oceanospirillales	135619|Oceanospirillales	T	7TMR-DISM extracellular 2	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
CMS1_k127_3484632_3	1541065.JRFE01000016_gene573	0.00012	49.0	COG0515@1|root,COG0515@2|Bacteria,1G0M9@1117|Cyanobacteria,3VHVK@52604|Pleurocapsales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
CMS1_k127_3484632_2	1123325.JHUV01000011_gene1407	1.407e-40	158.0	COG0500@1|root,COG2226@2|Bacteria,2G5BY@200783|Aquificae	200783|Aquificae	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_31
CMS1_k127_3484632_1	880073.Calab_0464	2.207e-47	181.0	COG0382@1|root,COG0382@2|Bacteria,2NP4W@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
CMS1_k127_3484632_0	574087.Acear_0505	7.647e-190	603.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,3WB84@53433|Halanaerobiales	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
CMS1_k127_3489825_0	269799.Gmet_0101	1.082e-132	444.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,42V17@68525|delta/epsilon subdivisions,2WRD3@28221|Deltaproteobacteria,43U6Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
CMS1_k127_3493444_0	574087.Acear_1736	3.017e-98	335.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,3WBC7@53433|Halanaerobiales	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
CMS1_k127_3493444_3	269799.Gmet_1936	5.268e-12	69.0	COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2WSNI@28221|Deltaproteobacteria,43VHI@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
CMS1_k127_3493444_2	498742.BSPA14S_0482	3.394e-21	100.0	COG0597@1|root,COG0597@2|Bacteria,2J7QV@203691|Spirochaetes	203691|Spirochaetes	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
CMS1_k127_3493444_1	857293.CAAU_1305	1.365e-47	178.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,36DSA@31979|Clostridiaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
CMS1_k127_3496935_3	161156.JQKW01000008_gene449	4.719e-07	53.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
CMS1_k127_3496935_0	573413.Spirs_4256	4.28e-53	198.0	COG1216@1|root,COG1216@2|Bacteria,2J8D4@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_3496935_1	419665.Maeo_0391	3.655e-24	117.0	COG2244@1|root,arCOG02209@2157|Archaea,2XSUR@28890|Euryarchaeota,23QGV@183939|Methanococci	183939|Methanococci	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
CMS1_k127_3496935_2	313603.FB2170_07429	1.044e-10	72.0	COG1807@1|root,COG1807@2|Bacteria,4NJ43@976|Bacteroidetes,1HX9S@117743|Flavobacteriia,2PH4F@252356|Maribacter	976|Bacteroidetes	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
CMS1_k127_3506358_4	103690.17130811	1.17e-28	119.0	COG1309@1|root,COG1309@2|Bacteria,1GKZE@1117|Cyanobacteria,1HR5G@1161|Nostocales	1117|Cyanobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_10,TetR_N
CMS1_k127_3506358_6	911045.PSE_0782	5.439e-16	84.0	28PBE@1|root,2ZC48@2|Bacteria,1N51N@1224|Proteobacteria,2UEMV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3506358_0	1294142.CINTURNW_1895	1.703e-109	366.0	COG2220@1|root,COG2220@2|Bacteria,1TRRP@1239|Firmicutes,24AQ5@186801|Clostridia,36VHG@31979|Clostridiaceae	186801|Clostridia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS1_k127_3506358_5	748449.Halha_0949	2.267e-20	96.0	COG2906@1|root,COG2906@2|Bacteria,1UZU8@1239|Firmicutes,24GGE@186801|Clostridia	186801|Clostridia	P	2Fe-2S -binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
CMS1_k127_3506358_2	756499.Desde_2677	9.753e-49	177.0	COG0346@1|root,COG0346@2|Bacteria,1V6CB@1239|Firmicutes,25BFW@186801|Clostridia,265DN@186807|Peptococcaceae	186801|Clostridia	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
CMS1_k127_3506358_3	266748.HY04_05035	3.941e-29	122.0	COG0457@1|root,COG0457@2|Bacteria,4NSXM@976|Bacteroidetes	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
CMS1_k127_3506358_1	313606.M23134_01691	1.099e-100	345.0	COG0464@1|root,COG0464@2|Bacteria,4NH44@976|Bacteroidetes,47RMN@768503|Cytophagia	976|Bacteroidetes	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS1_k127_353665_0	869209.Tresu_0375	2.446e-39	154.0	COG0739@1|root,COG0739@2|Bacteria,2J6RF@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	nlpD	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
CMS1_k127_353665_1	204536.SULAZ_1315	4.051e-05	55.0	COG0517@1|root,COG2199@1|root,COG2905@1|root,COG0517@2|Bacteria,COG2905@2|Bacteria,COG3706@2|Bacteria,2G47E@200783|Aquificae	200783|Aquificae	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GGDEF
CMS1_k127_3539362_0	509191.AEDB02000067_gene921	1.085e-40	168.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS1_k127_3544721_2	1265505.ATUG01000001_gene4121	2.602e-135	446.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,2MHW0@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
CMS1_k127_3544721_1	509191.AEDB02000067_gene921	3.372e-190	614.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3WGCA@541000|Ruminococcaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
CMS1_k127_3544721_5	857087.Metme_2085	4.587e-26	112.0	COG3585@1|root,COG3585@2|Bacteria,1N7IB@1224|Proteobacteria,1S7IP@1236|Gammaproteobacteria,1XF5P@135618|Methylococcales	135618|Methylococcales	H	TIGRFAM Molybdenum-pterin binding	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	TOBE
CMS1_k127_3544721_0	1056820.KB900685_gene2814	1.078e-214	685.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,2PQ0K@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
CMS1_k127_3544721_6	377629.TERTU_4300	3.056e-18	86.0	COG0236@1|root,COG0236@2|Bacteria,1NC80@1224|Proteobacteria,1SJ0G@1236|Gammaproteobacteria,2PQHY@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
CMS1_k127_3544721_3	44251.PDUR_16090	4.344e-61	224.0	COG0037@1|root,COG0037@2|Bacteria,1V113@1239|Firmicutes,4I035@91061|Bacilli,26QBH@186822|Paenibacillaceae	91061|Bacilli	D	tRNA processing	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3544721_4	203119.Cthe_1904	1.252e-59	221.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
CMS1_k127_3547297_2	889378.Spiaf_0607	7.715e-43	160.0	COG2201@1|root,COG2201@2|Bacteria,2JAI9@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Response regulator receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
CMS1_k127_3547297_1	889378.Spiaf_0608	6.634e-53	190.0	COG1406@1|root,COG1406@2|Bacteria,2JAIP@203691|Spirochaetes	203691|Spirochaetes	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
CMS1_k127_3547297_0	1480694.DC28_04500	2.27e-251	793.0	COG0004@1|root,COG0643@1|root,COG0004@2|Bacteria,COG0643@2|Bacteria,2JA63@203691|Spirochaetes	203691|Spirochaetes	NPT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,HATPase_c,Hpt
CMS1_k127_3547527_5	869213.JCM21142_104376	6.439e-25	107.0	COG2005@1|root,COG2005@2|Bacteria,4NUSR@976|Bacteroidetes,47RBD@768503|Cytophagia	976|Bacteroidetes	S	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
CMS1_k127_3547527_1	694427.Palpr_0502	3.656e-82	275.0	COG1720@1|root,COG1720@2|Bacteria,4NQ9Q@976|Bacteroidetes,2FV2B@200643|Bacteroidia,23179@171551|Porphyromonadaceae	976|Bacteroidetes	C	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
CMS1_k127_3547527_2	1408473.JHXO01000006_gene1439	4.762e-77	271.0	COG4148@1|root,COG4148@2|Bacteria,4PPT5@976|Bacteroidetes,2G18U@200643|Bacteroidia	976|Bacteroidetes	P	TOBE domain	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
CMS1_k127_3547527_3	1408473.JHXO01000006_gene1438	2.075e-69	242.0	COG4149@1|root,COG4149@2|Bacteria,4NIXK@976|Bacteroidetes,2FMCS@200643|Bacteroidia	976|Bacteroidetes	P	Binding-protein-dependent transport system inner membrane component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
CMS1_k127_3547527_4	1168034.FH5T_11450	5.89e-50	187.0	COG0725@1|root,COG0725@2|Bacteria,4NYF7@976|Bacteroidetes,2G398@200643|Bacteroidia	976|Bacteroidetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
CMS1_k127_3547527_0	869213.JCM21142_104372	4.618e-112	374.0	COG3746@1|root,COG3746@2|Bacteria,4P3MR@976|Bacteroidetes	976|Bacteroidetes	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
CMS1_k127_3552974_1	189425.PGRAT_08405	1.722e-15	91.0	2C940@1|root,33U40@2|Bacteria,1VV6F@1239|Firmicutes,4I7C9@91061|Bacilli,26WCX@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF1611_C) P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611
CMS1_k127_3552974_0	927677.ALVU02000002_gene392	1.335e-22	114.0	COG1215@1|root,COG1215@2|Bacteria,1GPY1@1117|Cyanobacteria,1H6S1@1142|Synechocystis	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_3552974_2	1216967.L100_11233	1.17e-06	59.0	2DPUM@1|root,333FC@2|Bacteria,4NQDW@976|Bacteroidetes,1IJD6@117743|Flavobacteriia,34QH8@308865|Elizabethkingia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3553147_7	1500893.JQNB01000001_gene1830	6.436e-16	92.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1X3UE@135614|Xanthomonadales	135614|Xanthomonadales	S	UPF0761 membrane protein	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS1_k127_3553147_6	1121859.KB890738_gene3530	5.283e-17	96.0	COG4447@1|root,COG4447@2|Bacteria,4NRP7@976|Bacteroidetes	976|Bacteroidetes	UW	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
CMS1_k127_3553147_8	1499686.BN1079_01005	1.305e-07	65.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	UPF0761 membrane protein	rbn	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
CMS1_k127_3553147_9	289376.THEYE_A1607	0.0001194	53.0	COG0810@1|root,COG0810@2|Bacteria,3J0U0@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
CMS1_k127_3553147_5	521674.Plim_0653	3.962e-73	262.0	COG1207@1|root,COG1207@2|Bacteria,2IXBV@203682|Planctomycetes	203682|Planctomycetes	M	Sugar nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_4
CMS1_k127_3553147_0	744872.Spica_1626	1.274e-178	583.0	COG0480@1|root,COG0480@2|Bacteria,2J5YJ@203691|Spirochaetes	203691|Spirochaetes	J	translation elongation factor	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
CMS1_k127_3553147_2	1172190.M947_11325	5.297e-162	522.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2YMW3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
CMS1_k127_3553147_3	515635.Dtur_0573	8.548e-111	375.0	COG1086@1|root,COG1086@2|Bacteria	2|Bacteria	GM	Polysaccharide biosynthesis protein	pglF	GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192	4.2.1.115,4.2.1.135,4.2.1.46	ko:K01710,ko:K15894,ko:K15912,ko:K19421	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R06513,R09697	RC00402,RC02609	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding_3,Polysacc_synt_2
CMS1_k127_3553147_1	204536.SULAZ_0355	3.604e-163	521.0	COG0399@1|root,COG0399@2|Bacteria,2G4VK@200783|Aquificae	200783|Aquificae	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
CMS1_k127_3553147_4	1541065.JRFE01000024_gene1023	3.667e-81	285.0	COG2148@1|root,COG2148@2|Bacteria,1G32D@1117|Cyanobacteria,3VHV8@52604|Pleurocapsales	1117|Cyanobacteria	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
CMS1_k127_3553475_3	1410617.JHXH01000004_gene1345	1.562e-35	152.0	COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,3WGCG@541000|Ruminococcaceae	186801|Clostridia	KT	stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,HATPase_c_2,PAS_9,SpoIIE,dCache_1
CMS1_k127_3553475_2	526224.Bmur_0261	9.68e-54	201.0	COG0564@1|root,COG0564@2|Bacteria,2JAN4@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS1_k127_3553475_4	2325.TKV_c23470	2.322e-33	135.0	2CA4A@1|root,32RQK@2|Bacteria,1VE2U@1239|Firmicutes,24QHD@186801|Clostridia,42GU9@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
CMS1_k127_3553475_0	1121091.AUMP01000020_gene3691	9.663e-122	396.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli	91061|Bacilli	C	reductase	yvgN	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS1_k127_3553475_1	28072.Nos7524_0717	1.03e-72	263.0	COG0641@1|root,COG0641@2|Bacteria,1FZZY@1117|Cyanobacteria,1HRV7@1161|Nostocales	1117|Cyanobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_3553475_5	32057.KB217478_gene1508	2.423e-31	145.0	COG1572@1|root,COG1572@2|Bacteria,1GE0K@1117|Cyanobacteria,1HRW1@1161|Nostocales	1117|Cyanobacteria	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS1_k127_3556497_2	880073.Calab_3372	2.44e-34	143.0	COG1032@1|root,COG1032@2|Bacteria,2NQ35@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
CMS1_k127_3556497_1	1246626.BleG1_1386	7.211e-51	184.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,1ZG82@1386|Bacillus	91061|Bacilli	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
CMS1_k127_3556497_0	1216932.CM240_0433	1.882e-81	278.0	COG1708@1|root,COG1708@2|Bacteria,1VPY0@1239|Firmicutes,25GBZ@186801|Clostridia,36V42@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4037,NTP_transf_2
CMS1_k127_3556497_3	582744.Msip34_1538	1.104e-07	57.0	2DNS2@1|root,32YVY@2|Bacteria,1N9QQ@1224|Proteobacteria,2VY3B@28216|Betaproteobacteria,2KNXC@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3556497_4	1121007.AUML01000027_gene1942	7.504e-07	55.0	COG4886@1|root,COG4886@2|Bacteria,4NPNU@976|Bacteroidetes,1I2Q2@117743|Flavobacteriia,2YH6M@290174|Aquimarina	976|Bacteroidetes	S	Leucine Rich Repeat	-	-	-	-	-	-	-	-	-	-	-	-	LRR_4,LRR_6,LRR_8,Pkinase_Tyr
CMS1_k127_3562291_1	382464.ABSI01000005_gene1026	5.834e-97	332.0	COG4284@1|root,COG4284@2|Bacteria,46U9U@74201|Verrucomicrobia	74201|Verrucomicrobia	G	UTP--glucose-1-phosphate uridylyltransferase	-	-	2.7.7.23,2.7.7.64,2.7.7.83	ko:K00972,ko:K12447	ko00040,ko00052,ko00053,ko00520,ko01100,ko01130,map00040,map00052,map00053,map00520,map01100,map01130	M00014,M00361,M00362	R00289,R00416,R00502,R01381,R03077,R08845	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
CMS1_k127_3562291_0	1499967.BAYZ01000196_gene3073	6.855e-124	411.0	COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria	2|Bacteria	G	MOFRL family	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
CMS1_k127_3566376_5	941824.TCEL_01143	1.108e-48	182.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,36EIP@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
CMS1_k127_3566376_1	1121865.OMW_00925	6.37e-132	426.0	COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,4H9R0@91061|Bacilli,4B0GS@81852|Enterococcaceae	91061|Bacilli	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS1_k127_3566376_4	247490.KSU1_D0777	1.64e-65	228.0	COG1898@1|root,COG1898@2|Bacteria,2IZMV@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
CMS1_k127_3566376_3	565034.BHWA1_02693	1.269e-86	295.0	COG1091@1|root,COG1091@2|Bacteria,2J5U8@203691|Spirochaetes	203691|Spirochaetes	C	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
CMS1_k127_3566376_0	522772.Dacet_2762	2.949e-169	537.0	COG1088@1|root,COG1088@2|Bacteria,2GFAW@200930|Deferribacteres	200930|Deferribacteres	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CMS1_k127_3566376_2	1123288.SOV_1c01800	5.732e-124	402.0	COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,4H3X1@909932|Negativicutes	909932|Negativicutes	M	PFAM UDP-glucose GDP-mannose dehydrogenase, UDP-glucose GDP-mannose dehydrogenase , UDP-glucose GDP-mannose dehydrogenase dimerization	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS1_k127_3569413_0	158189.SpiBuddy_2288	2.034e-153	506.0	COG1198@1|root,COG1198@2|Bacteria,2J5B4@203691|Spirochaetes	203691|Spirochaetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
CMS1_k127_3569413_1	926561.KB900623_gene1170	1.312e-08	62.0	COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,3WAMY@53433|Halanaerobiales	186801|Clostridia	L	PFAM Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
CMS1_k127_3570362_4	765911.Thivi_0317	3.615e-13	72.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWY7@135613|Chromatiales	135613|Chromatiales	NT	Signal transducing histidine kinase, homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
CMS1_k127_3570362_3	1215092.PA6_029_00140	2.066e-43	169.0	COG0834@1|root,COG0834@2|Bacteria,1RIR9@1224|Proteobacteria,1T0RK@1236|Gammaproteobacteria,1YFVA@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
CMS1_k127_3570362_1	926567.TheveDRAFT_1228	2.156e-60	227.0	COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,3TAAM@508458|Synergistetes	508458|Synergistetes	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
CMS1_k127_3570362_2	562743.JH976435_gene2758	2.034e-53	196.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H9WY@91061|Bacilli	91061|Bacilli	E	abc transporter atp-binding protein	artM	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
CMS1_k127_3570362_0	1167006.UWK_00280	2.743e-64	226.0	COG2095@1|root,COG2095@2|Bacteria,1REDU@1224|Proteobacteria	1224|Proteobacteria	U	MarC family integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
CMS1_k127_3600963_1	1480694.DC28_02435	1.774e-88	300.0	COG0455@1|root,COG0455@2|Bacteria,2J5B7@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
CMS1_k127_3600963_2	445335.CBN_2629	1.113e-60	226.0	COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,249R1@186801|Clostridia,36EPY@31979|Clostridiaceae	186801|Clostridia	N	flagellar biosynthesis protein FlhF	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
CMS1_k127_3600963_0	574087.Acear_1624	2.032e-210	675.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,3WABD@53433|Halanaerobiales	186801|Clostridia	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
CMS1_k127_3605664_2	1220589.CD32_00390	1.815e-19	96.0	COG1357@1|root,COG1357@2|Bacteria,1V6IF@1239|Firmicutes,4IQ2Z@91061|Bacilli	91061|Bacilli	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
CMS1_k127_3605664_0	246197.MXAN_7256	1.176e-26	126.0	COG4223@1|root,COG4223@2|Bacteria	2|Bacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	AHH,SLH
CMS1_k127_3605664_1	388467.A19Y_2181	2.534e-23	115.0	COG3064@1|root,COG5412@1|root,COG3064@2|Bacteria,COG5412@2|Bacteria,1G8FK@1117|Cyanobacteria,1HI1M@1150|Oscillatoriales	1117|Cyanobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
CMS1_k127_360972_2	406327.Mevan_0105	2.011e-14	75.0	arCOG12656@1|root,arCOG12656@2157|Archaea,2Y4IC@28890|Euryarchaeota,23RR5@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_360972_0	406327.Mevan_0111	4.088e-72	263.0	COG0598@1|root,arCOG02265@2157|Archaea,2Y2U3@28890|Euryarchaeota,23RHG@183939|Methanococci	183939|Methanococci	P	CorA-like Mg2+ transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	CorA
CMS1_k127_360972_1	747365.Thena_0814	1.782e-17	84.0	COG1583@1|root,COG1583@2|Bacteria,1TRPW@1239|Firmicutes,24A33@186801|Clostridia,42FEF@68295|Thermoanaerobacterales	186801|Clostridia	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA)	cas6	-	-	ko:K19091	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas6
CMS1_k127_3618931_1	1284352.AOIG01000018_gene4363	9.477e-105	370.0	COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1UII2@1239|Firmicutes,4HGW5@91061|Bacilli,26QEY@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
CMS1_k127_3618931_3	273068.TTE1633	4.018e-23	108.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_3618931_0	526222.Desal_0650	3.776e-320	1000.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2M9Q4@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
CMS1_k127_3618931_2	1123248.KB893325_gene1138	3.174e-29	118.0	2E3B3@1|root,32YAM@2|Bacteria,4NW81@976|Bacteroidetes,1ITTZ@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
CMS1_k127_36221_0	762903.Pedsa_2916	1.113e-116	387.0	COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes,1INTU@117747|Sphingobacteriia	976|Bacteroidetes	J	PUA domain containing protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
CMS1_k127_3631974_4	697303.Thewi_2448	1.562e-07	57.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24QK6@186801|Clostridia,42I9F@68295|Thermoanaerobacterales	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_3631974_2	767817.Desgi_1007	2.09e-11	65.0	COG3646@1|root,COG3646@2|Bacteria,1UICZ@1239|Firmicutes,25EHY@186801|Clostridia	186801|Clostridia	S	KilA-N	-	-	-	-	-	-	-	-	-	-	-	-	KilA-N
CMS1_k127_3631974_3	887325.HMPREF0381_0996	2.672e-08	55.0	COG3646@1|root,COG3646@2|Bacteria,1UICZ@1239|Firmicutes,25EHY@186801|Clostridia,1HV2Y@1164882|Lachnoanaerobaculum	186801|Clostridia	S	KilA-N	-	-	-	-	-	-	-	-	-	-	-	-	KilA-N
CMS1_k127_3631974_1	676032.FN3523_0728	1.38e-32	141.0	29U29@1|root,30FBH@2|Bacteria,1R3MT@1224|Proteobacteria,1SNM7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3631974_0	1123274.KB899409_gene492	4.331e-116	384.0	COG0232@1|root,COG0232@2|Bacteria,2J69E@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Metal-dependent phosphohydrolase, HD	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
CMS1_k127_3632390_5	1121405.dsmv_0466	0.0001352	52.0	COG4970@1|root,COG4970@2|Bacteria,1NAVW@1224|Proteobacteria,42V4H@68525|delta/epsilon subdivisions,2WRE8@28221|Deltaproteobacteria,2MM4W@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
CMS1_k127_3632390_3	1379858.N508_02009	2.301e-47	174.0	COG2165@1|root,COG2165@2|Bacteria,2GFJI@200930|Deferribacteres	200930|Deferribacteres	U	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
CMS1_k127_3632390_2	373903.Hore_05990	5.163e-75	267.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,3WAFC@53433|Halanaerobiales	186801|Clostridia	U	PFAM Bacterial type II secretion system protein F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS1_k127_3632390_0	439235.Dalk_5144	2.669e-168	546.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MHPE@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
CMS1_k127_3632390_1	56780.SYN_01548	5.227e-77	280.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2MR1J@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	Bacterial type II/III secretion system short domain	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
CMS1_k127_3632390_4	387093.SUN_0029	1.79e-06	59.0	COG3031@1|root,COG3031@2|Bacteria,1NB50@1224|Proteobacteria,42WPG@68525|delta/epsilon subdivisions,2YQJN@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	-
CMS1_k127_3632392_1	572547.Amico_1194	1.937e-113	381.0	COG2239@1|root,COG2239@2|Bacteria,3TAGT@508458|Synergistetes	508458|Synergistetes	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
CMS1_k127_3632392_0	1123239.KB898626_gene648	3.851e-149	479.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,4HAN7@91061|Bacilli	91061|Bacilli	M	Nad-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
CMS1_k127_3633921_0	665571.STHERM_c07960	1.253e-153	497.0	COG1055@1|root,COG1055@2|Bacteria,2J6QU@203691|Spirochaetes	203691|Spirochaetes	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp
CMS1_k127_3633921_3	643562.Daes_1368	8.376e-30	131.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria,2M8GP@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS1_k127_3633921_1	1307761.L21SP2_1191	3.954e-151	484.0	COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes	203691|Spirochaetes	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
CMS1_k127_3633921_2	398767.Glov_3599	1.087e-127	425.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,42MT3@68525|delta/epsilon subdivisions,2WIK5@28221|Deltaproteobacteria,43T31@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_binding_3,HI0933_like,Pyr_redox_2
CMS1_k127_3633921_4	1191523.MROS_1267	3.967e-14	83.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS1_k127_3633921_5	933262.AXAM01000003_gene2828	9.07e-10	70.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42PGI@68525|delta/epsilon subdivisions,2WMBT@28221|Deltaproteobacteria,2MPXH@213118|Desulfobacterales	28221|Deltaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS1_k127_3652028_0	1499680.CCFE01000011_gene764	6.752e-40	162.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K20276,ko:K21449	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	1.B.40.2	-	-	FTP,He_PIG,PA,Peptidase_M30,Peptidase_M36,Reprolysin_4,SLH,fn3
CMS1_k127_3657234_5	596330.HMPREF0628_0723	9.159e-11	73.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,22GF2@1570339|Peptoniphilaceae	186801|Clostridia	KLT	Kinase domain protein	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
CMS1_k127_3657234_3	702437.HMPREF9432_01086	4.855e-23	100.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4H53P@909932|Negativicutes	909932|Negativicutes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
CMS1_k127_3657234_2	1123274.KB899415_gene2482	1.251e-30	122.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
CMS1_k127_3657234_4	1121422.AUMW01000002_gene2176	1.353e-13	78.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,2623V@186807|Peptococcaceae	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
CMS1_k127_3657234_0	1408254.T458_16685	1.82e-71	249.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,26RCU@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
CMS1_k127_3657234_1	545694.TREPR_3157	1.534e-35	139.0	COG0335@1|root,COG0335@2|Bacteria,2J825@203691|Spirochaetes	203691|Spirochaetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
CMS1_k127_3657234_6	1120917.AQXM01000035_gene1241	5.509e-06	50.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,1W93N@1268|Micrococcaceae	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
CMS1_k127_3679712_1	1196095.GAPWK_0758	2.789e-55	196.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hinT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
CMS1_k127_3679712_6	498211.CJA_1330	0.0005298	45.0	COG2900@1|root,COG2900@2|Bacteria,1NGFM@1224|Proteobacteria,1SGAM@1236|Gammaproteobacteria,1FHP4@10|Cellvibrio	1236|Gammaproteobacteria	S	SlyX	slyX	-	-	ko:K03745	-	-	-	-	ko00000	-	-	-	SlyX
CMS1_k127_3679712_4	1128427.KB904821_gene1249	1.659e-20	93.0	COG4095@1|root,COG4095@2|Bacteria,1G9AI@1117|Cyanobacteria,1HCTA@1150|Oscillatoriales	1117|Cyanobacteria	S	PQ loop repeat	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	MtN3_slv,PQ-loop
CMS1_k127_3679712_3	459349.CLOAM1624	8.958e-24	117.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,2NPWP@2323|unclassified Bacteria	2|Bacteria	M	OmpA family	pal	-	-	ko:K03286,ko:K03640	-	-	-	-	ko00000,ko02000	1.B.6,2.C.1.2	-	-	CarboxypepD_reg,OmpA,PD40
CMS1_k127_3679712_5	1262449.CP6013_0932	2.959e-16	87.0	COG0664@1|root,COG0664@2|Bacteria,1V3XW@1239|Firmicutes,24HXX@186801|Clostridia,36VUG@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914,ko:K21563	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_3679712_2	32049.SYNPCC7002_A2608	1.66e-24	113.0	298GU@1|root,2ZVMX@2|Bacteria,1GPCJ@1117|Cyanobacteria,1H2WA@1129|Synechococcus	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3679712_0	118161.KB235922_gene2056	9.62e-75	258.0	COG0500@1|root,COG2226@2|Bacteria,1G3V3@1117|Cyanobacteria,3VKIZ@52604|Pleurocapsales	1117|Cyanobacteria	Q	COGs COG2226 Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS1_k127_3700546_0	533240.CRC_01252	8.195e-18	96.0	COG0834@1|root,COG1404@1|root,COG1409@1|root,COG1520@1|root,COG2133@1|root,COG2931@1|root,COG3386@1|root,COG3537@1|root,COG5164@1|root,COG0834@2|Bacteria,COG1404@2|Bacteria,COG1409@2|Bacteria,COG1520@2|Bacteria,COG2133@2|Bacteria,COG2931@2|Bacteria,COG3386@2|Bacteria,COG3537@2|Bacteria,COG5164@2|Bacteria,1G2N0@1117|Cyanobacteria,1HRSX@1161|Nostocales	1117|Cyanobacteria	GOQ	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,DUF4114,DUF4347,HemolysinCabind,Laminin_G_3,SBP_bac_3,VCBS
CMS1_k127_3714615_0	522772.Dacet_2287	7.148e-144	465.0	COG0162@1|root,COG0162@2|Bacteria,2GENZ@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
CMS1_k127_3714615_2	509191.AEDB02000109_gene4960	2.252e-31	130.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,3WIW4@541000|Ruminococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_3714615_1	926692.AZYG01000019_gene239	4.804e-101	346.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WAG5@53433|Halanaerobiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
CMS1_k127_3737556_2	860228.Ccan_19770	5.131e-10	65.0	2E3MC@1|root,32YJJ@2|Bacteria,4NWQZ@976|Bacteroidetes,1II79@117743|Flavobacteriia,1ESF3@1016|Capnocytophaga	976|Bacteroidetes	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
CMS1_k127_3737556_1	1123508.JH636440_gene2074	9.652e-13	72.0	COG2314@1|root,COG2314@2|Bacteria,2J1MD@203682|Planctomycetes	203682|Planctomycetes	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_375452_0	317936.Nos7107_2747	9.331e-62	230.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_375452_1	755731.Clo1100_3102	4.856e-09	58.0	COG1032@1|root,COG1032@2|Bacteria,1VT7Y@1239|Firmicutes,24ZAZ@186801|Clostridia,36RC1@31979|Clostridiaceae	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS1_k127_3761097_3	903818.KI912269_gene370	1.53e-27	124.0	COG4099@1|root,COG4099@2|Bacteria	2|Bacteria	F	phospholipase Carboxylesterase	-	-	3.5.4.40	ko:K18286	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_2,Abhydrolase_8,Peptidase_S9
CMS1_k127_3761097_2	269798.CHU_3598	1.792e-39	149.0	COG0347@1|root,COG0347@2|Bacteria	2|Bacteria	K	Belongs to the P(II) protein family	glnB	-	-	ko:K03320,ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	1.A.11	-	-	Ammonium_transp,P-II
CMS1_k127_3761097_0	1121373.KB903621_gene1765	2.618e-187	592.0	COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes	976|Bacteroidetes	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CMS1_k127_3761097_4	1121447.JONL01000001_gene464	4.279e-23	103.0	COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,1R4W2@1224|Proteobacteria,43CSC@68525|delta/epsilon subdivisions,2X7ZZ@28221|Deltaproteobacteria,2MHG3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS1_k127_3761097_1	333138.LQ50_07170	4.509e-65	245.0	COG3437@1|root,COG4251@1|root,COG3437@2|Bacteria,COG4251@2|Bacteria,1UJG9@1239|Firmicutes,4IT8Z@91061|Bacilli,1ZSAH@1386|Bacillus	91061|Bacilli	T	Four helix bundle sensory module for signal transduction	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	4HB_MCP_1,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
CMS1_k127_3763280_1	1122134.KB893650_gene1107	4.839e-26	113.0	2BK9M@1|root,32EPT@2|Bacteria,1NC6I@1224|Proteobacteria,1SV8Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3763280_0	1121938.AUDY01000013_gene3212	4.208e-75	258.0	COG0225@1|root,COG0225@2|Bacteria,1TQ3E@1239|Firmicutes,4HAIV@91061|Bacilli,3ND8T@45667|Halobacillus	91061|Bacilli	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
CMS1_k127_3779425_7	403833.Pmob_1460	2.836e-59	212.0	COG1180@1|root,COG1180@2|Bacteria,2GC8W@200918|Thermotogae	200918|Thermotogae	C	Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_3779425_2	290315.Clim_1112	1.129e-106	353.0	COG0190@1|root,COG0190@2|Bacteria,1FE78@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
CMS1_k127_3779425_0	926561.KB900618_gene229	2.526e-216	697.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,3WA7C@53433|Halanaerobiales	186801|Clostridia	H	PFAM Pterin binding enzyme	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
CMS1_k127_3779425_3	1289135.A966_05778	7.334e-104	345.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
CMS1_k127_3779425_4	1125700.HMPREF9195_00384	5.576e-91	307.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
CMS1_k127_3779425_11	645991.Sgly_0586	8.84e-10	66.0	COG1334@1|root,COG1334@2|Bacteria,1TXKD@1239|Firmicutes,2596V@186801|Clostridia,262GF@186807|Peptococcaceae	186801|Clostridia	N	PFAM FlaG protein	-	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	FlaG
CMS1_k127_3779425_12	1265505.ATUG01000001_gene3775	1.896e-09	71.0	COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,42MHW@68525|delta/epsilon subdivisions,2WMMQ@28221|Deltaproteobacteria,2MIGN@213118|Desulfobacterales	28221|Deltaproteobacteria	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	-	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
CMS1_k127_3779425_9	526224.Bmur_1499	1.677e-23	112.0	2DF69@1|root,2ZQMH@2|Bacteria,2J89G@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3779425_1	886379.AEWI01000006_gene734	1.66e-119	395.0	COG4658@1|root,COG4658@2|Bacteria,4NFGW@976|Bacteroidetes,2FMD0@200643|Bacteroidia,3XIVE@558415|Marinilabiliaceae	976|Bacteroidetes	C	NQR2, RnfD, RnfE family	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
CMS1_k127_3779425_8	655815.ZPR_0950	8.589e-37	148.0	COG2869@1|root,COG2869@2|Bacteria,4NF7A@976|Bacteroidetes,1HZG0@117743|Flavobacteriia	976|Bacteroidetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
CMS1_k127_3779425_6	1122975.AQVC01000044_gene347	1.151e-68	238.0	COG1347@1|root,COG1347@2|Bacteria,4NGD9@976|Bacteroidetes,2FN5K@200643|Bacteroidia,22VYS@171551|Porphyromonadaceae	976|Bacteroidetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS1_k127_3779425_5	1279009.ADICEAN_03177	6.51e-69	237.0	COG2209@1|root,COG2209@2|Bacteria,4NEU0@976|Bacteroidetes,47KRI@768503|Cytophagia	976|Bacteroidetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
CMS1_k127_3810239_2	582515.KR51_00026660	4.948e-96	334.0	COG1132@1|root,COG1132@2|Bacteria,1G0C0@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
CMS1_k127_3810239_6	936155.HFELIS_00250	1.453e-35	153.0	COG4403@1|root,COG4403@2|Bacteria,1R8VP@1224|Proteobacteria,432AY@68525|delta/epsilon subdivisions	1224|Proteobacteria	V	Domain of unknown function (DUF4135)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4135,LANC_like
CMS1_k127_3810239_1	1329516.JPST01000006_gene1596	8.276e-146	496.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,4H9WA@91061|Bacilli,27BAN@186824|Thermoactinomycetaceae	91061|Bacilli	D	Ftsk_gamma	ftsK	GO:0000003,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019954,GO:0030436,GO:0031323,GO:0031326,GO:0032502,GO:0043934,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
CMS1_k127_3810239_4	1347392.CCEZ01000043_gene372	1.106e-45	175.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,36EFN@31979|Clostridiaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
CMS1_k127_3810239_0	720554.Clocl_2287	8.245e-157	512.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,3WH9M@541000|Ruminococcaceae	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
CMS1_k127_3810239_3	1094508.Tsac_1837	1.781e-51	185.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia,42GTP@68295|Thermoanaerobacterales	186801|Clostridia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
CMS1_k127_3810239_5	243275.TDE_1128	7.991e-40	162.0	2EZ7M@1|root,33SDH@2|Bacteria,2J5HE@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3813620_6	1230342.CTM_19334	4.065e-27	117.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
CMS1_k127_3813620_5	1499967.BAYZ01000090_gene4948	8.154e-52	191.0	COG5036@1|root,COG5036@2|Bacteria	2|Bacteria	P	cellular response to phosphate starvation	-	-	-	-	-	-	-	-	-	-	-	-	VTC
CMS1_k127_3813620_4	1499967.BAYZ01000090_gene4947	1.981e-59	214.0	2ATYU@1|root,31JIG@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
CMS1_k127_3813620_3	1499967.BAYZ01000090_gene4946	1.909e-104	360.0	2C2BG@1|root,32RA5@2|Bacteria	2|Bacteria	S	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
CMS1_k127_3813620_0	269797.Mbar_A1676	6.151e-174	554.0	COG1840@1|root,arCOG03984@2157|Archaea,2Y3FV@28890|Euryarchaeota,2NARF@224756|Methanomicrobia	224756|Methanomicrobia	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
CMS1_k127_3813620_2	269797.Mbar_A1675	9.719e-111	361.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUHE@28890|Euryarchaeota,2N9QP@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM cobalamin synthesis protein P47K	-	-	-	-	-	-	-	-	-	-	-	-	cobW
CMS1_k127_3813620_1	269797.Mbar_A1674	7.981e-114	376.0	COG1136@1|root,arCOG03228@2157|Archaea,2XVM5@28890|Euryarchaeota,2N9ID@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
CMS1_k127_3813620_7	161156.JQKW01000007_gene632	8.715e-14	76.0	COG0639@1|root,COG0639@2|Bacteria,2GHP8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Calcineurin-like phosphoesterase	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
CMS1_k127_3817190_3	697303.Thewi_0541	8.633e-82	280.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,42F66@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
CMS1_k127_3817190_4	643867.Ftrac_2377	1.167e-21	105.0	COG2227@1|root,COG2227@2|Bacteria,4NGVF@976|Bacteroidetes,47K52@768503|Cytophagia	976|Bacteroidetes	H	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
CMS1_k127_3817190_0	485916.Dtox_0809	0.0	1058.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
CMS1_k127_3817190_1	1121451.DESAM_22761	2.105e-124	409.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42MBY@68525|delta/epsilon subdivisions,2WIR5@28221|Deltaproteobacteria,2M80X@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
CMS1_k127_3817190_2	1379698.RBG1_1C00001G0253	1.631e-97	344.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
CMS1_k127_3823083_0	439235.Dalk_0859	1.381e-81	312.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core	-	-	-	-	-	-	-	-	-	-	-	-	AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
CMS1_k127_3824757_0	1042377.AFPJ01000007_gene1783	6.939e-05	52.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,46853@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0032940,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
CMS1_k127_3827955_1	443254.Marpi_1315	4.58e-30	127.0	COG0424@1|root,COG0424@2|Bacteria,2GD4Y@200918|Thermotogae	200918|Thermotogae	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
CMS1_k127_3827955_0	926692.AZYG01000049_gene9	3.035e-195	630.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,3WADP@53433|Halanaerobiales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
CMS1_k127_3832961_0	1321815.HMPREF9193_00962	1.04e-30	124.0	2BU8T@1|root,32PI9@2|Bacteria,2JAX0@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3832961_2	1894.JOER01000071_gene7113	3.684e-11	66.0	arCOG11411@1|root,33A8Q@2|Bacteria,2GRHE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3832961_1	1321815.HMPREF9193_00540	6.283e-27	128.0	2BHY2@1|root,32C28@2|Bacteria,2J8U9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3833023_22	1235797.C816_03553	3.467e-09	63.0	COG1396@1|root,COG1396@2|Bacteria,1VEU8@1239|Firmicutes,24QN0@186801|Clostridia	186801|Clostridia	K	DNA-binding helix-turn-helix protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
CMS1_k127_3833023_0	398512.JQKC01000001_gene2152	6.256e-287	894.0	COG0635@1|root,COG1051@1|root,COG0635@2|Bacteria,COG1051@2|Bacteria,1TST7@1239|Firmicutes,249C3@186801|Clostridia,3WHXH@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Radical_SAM
CMS1_k127_3833023_23	1116375.VEJY3_22316	1.501e-08	58.0	28VN4@1|root,2ZHQ8@2|Bacteria,1P4YK@1224|Proteobacteria,1SU6C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3833023_4	1408473.JHXO01000013_gene515	1.37e-101	334.0	COG0108@1|root,COG0108@2|Bacteria,4NJXE@976|Bacteroidetes,2FPU2@200643|Bacteroidia	976|Bacteroidetes	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase
CMS1_k127_3833023_17	1121451.DESAM_21560	1.431e-46	185.0	COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,43ADW@68525|delta/epsilon subdivisions,2X5TV@28221|Deltaproteobacteria,2MGVZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K07640	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
CMS1_k127_3833023_9	526222.Desal_3050	1.579e-73	254.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,42MG4@68525|delta/epsilon subdivisions,2WN8P@28221|Deltaproteobacteria,2MA53@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_3833023_13	290512.Paes_1145	6.225e-69	250.0	COG1538@1|root,COG1538@2|Bacteria,1FDME@1090|Chlorobi	1090|Chlorobi	MU	PFAM outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
CMS1_k127_3833023_12	96561.Dole_1628	2.077e-70	249.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WM23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	macrolide-specific efflux protein	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
CMS1_k127_3833023_2	96561.Dole_1627	5.038e-205	657.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2X727@28221|Deltaproteobacteria,2MPJ4@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
CMS1_k127_3833023_3	1499967.BAYZ01000068_gene1935	3.586e-152	515.0	COG3266@1|root,COG3420@1|root,COG4733@1|root,COG3266@2|Bacteria,COG3420@2|Bacteria,COG4733@2|Bacteria,2NS5M@2323|unclassified Bacteria	2|Bacteria	P	Fibronectin type 3 domain	-	-	-	ko:K12685,ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02044	1.B.12.5.1,1.B.12.5.3,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CHB_HEX_C_1,CHU_C,DUF1573,DUF285,F5_F8_type_C,Laminin_G_3,Lectin_legB,fn3
CMS1_k127_3833023_20	1307761.L21SP2_0791	2.823e-20	107.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	aml1	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26,CBM53,CBM_25,CBM_35,CHB_HEX_C_1,fn3
CMS1_k127_3833023_8	1121441.AUCX01000017_gene1999	3.373e-90	302.0	COG2014@1|root,COG2014@2|Bacteria,1NFAE@1224|Proteobacteria,42NC4@68525|delta/epsilon subdivisions,2WKS2@28221|Deltaproteobacteria,2M9NZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative heavy-metal chelation	-	-	-	-	-	-	-	-	-	-	-	-	DUF364
CMS1_k127_3833023_18	694427.Palpr_1421	3.961e-46	175.0	COG3842@1|root,COG3842@2|Bacteria,4PKJB@976|Bacteroidetes,2G0RY@200643|Bacteroidia,2325P@171551|Porphyromonadaceae	976|Bacteroidetes	E	ATPases associated with a variety of cellular activities	potA	-	3.6.3.29,3.6.3.31	ko:K02017,ko:K11072	ko02010,map02010	M00189,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1,3.A.1.8	-	-	ABC_tran,TOBE_2
CMS1_k127_3833023_19	1242969.ATCC51562_700	1.668e-42	164.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,42S4V@68525|delta/epsilon subdivisions,2YN1X@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	ABC transporter permease	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
CMS1_k127_3833023_16	556267.HWAG_01083	1.365e-49	186.0	COG0725@1|root,COG0725@2|Bacteria,1MX18@1224|Proteobacteria,42Q1A@68525|delta/epsilon subdivisions,2YNDG@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	ABC transporter	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
CMS1_k127_3833023_10	931626.Awo_c34430	9.862e-72	243.0	COG3791@1|root,COG3791@2|Bacteria,1VMSS@1239|Firmicutes,24VSE@186801|Clostridia	186801|Clostridia	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
CMS1_k127_3833023_6	1198232.CYCME_2344	3.001e-91	310.0	COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,1RPSG@1236|Gammaproteobacteria,4608X@72273|Thiotrichales	72273|Thiotrichales	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
CMS1_k127_3833023_15	1047013.AQSP01000131_gene1831	4.76e-66	235.0	COG1578@1|root,COG1578@2|Bacteria,2NPE8@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF89	-	-	2.7.1.33	ko:K09116,ko:K09680	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF89
CMS1_k127_3833023_11	926561.KB900619_gene2428	1.491e-70	253.0	COG2365@1|root,COG2365@2|Bacteria,1TRAZ@1239|Firmicutes,2491G@186801|Clostridia	186801|Clostridia	T	Tyrosine phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	SAM_adeno_trans,Y_phosphatase3
CMS1_k127_3833023_7	398767.Glov_0178	7.741e-91	308.0	COG2207@1|root,COG2207@2|Bacteria,1MUEM@1224|Proteobacteria,42S1Y@68525|delta/epsilon subdivisions,2WP4J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	AraC-type transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,HTH_18
CMS1_k127_3833023_14	596152.DesU5LDRAFT_3009	2.188e-68	233.0	COG1917@1|root,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,42U9N@68525|delta/epsilon subdivisions,2WUT7@28221|Deltaproteobacteria,2MBPZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS1_k127_3833023_1	517418.Ctha_0789	1.438e-205	644.0	COG1979@1|root,COG1979@2|Bacteria,1FFQH@1090|Chlorobi	1090|Chlorobi	C	PFAM iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K08325	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R02528,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC00739,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
CMS1_k127_3833023_24	269797.Mbar_A0781	3.188e-05	47.0	COG0716@1|root,arCOG00519@2157|Archaea,2Y6DN@28890|Euryarchaeota,2N9NU@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
CMS1_k127_3833023_21	1089553.Tph_c21710	2.572e-19	87.0	COG0716@1|root,COG0716@2|Bacteria,1V465@1239|Firmicutes,24DQZ@186801|Clostridia,42FJH@68295|Thermoanaerobacterales	186801|Clostridia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
CMS1_k127_3833023_5	1120970.AUBZ01000007_gene2953	2.532e-99	337.0	COG2942@1|root,COG2942@2|Bacteria,1RAGB@1224|Proteobacteria,1S34A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	2-epimerase	VPA0780	-	-	-	-	-	-	-	-	-	-	-	GlcNAc_2-epim
CMS1_k127_3836698_1	492774.JQMB01000002_gene1203	7.452e-92	310.0	COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,2U36T@28211|Alphaproteobacteria,4B7H0@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, periplasmic component	thuE	-	-	ko:K10236	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	SBP_bac_1,SBP_bac_8
CMS1_k127_3836698_0	1167006.UWK_00694	2.346e-120	421.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
CMS1_k127_3836698_2	1232437.KL662036_gene2710	1.244e-61	219.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,42PI0@68525|delta/epsilon subdivisions,2WJ79@28221|Deltaproteobacteria,2MJT2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
CMS1_k127_3838004_0	272123.Anacy_4557	4.976e-15	85.0	COG0438@1|root,COG0438@2|Bacteria,1G0Z5@1117|Cyanobacteria,1HIGZ@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
CMS1_k127_3838004_1	1234679.BN424_2025	0.0003888	47.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4HATK@91061|Bacilli,27FTT@186828|Carnobacteriaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
CMS1_k127_3842150_0	316274.Haur_1779	4.435e-71	270.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	Dam,PhageMin_Tail
CMS1_k127_3859910_2	888743.HMPREF9141_2780	8.187e-27	109.0	COG1773@1|root,COG1773@2|Bacteria,4NHF0@976|Bacteroidetes,2FUN6@200643|Bacteroidia	976|Bacteroidetes	C	rubredoxin	rubR	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
CMS1_k127_3859910_0	1304885.AUEY01000026_gene3553	5.782e-218	693.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHT0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS1_k127_3859910_5	1382304.JNIL01000001_gene1716	3.236e-07	58.0	2EH6I@1|root,33AYE@2|Bacteria,1VP74@1239|Firmicutes,4HSH5@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3859910_1	273068.TTE2319	4.184e-194	621.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,42FHT@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
CMS1_k127_3859910_4	748280.NH8B_1148	8.871e-11	64.0	2DU2E@1|root,33NN7@2|Bacteria,1P5P1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3864362_3	316274.Haur_1783	1.357e-18	87.0	COG3628@1|root,COG3628@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2634
CMS1_k127_3864362_1	316274.Haur_1781	2.446e-62	224.0	COG3501@1|root,COG3501@2|Bacteria	2|Bacteria	T	Rhs element vgr protein	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Phage_GPD
CMS1_k127_3864362_2	102129.Lepto7375DRAFT_1401	3.145e-55	205.0	COG3500@1|root,COG3500@2|Bacteria,1GCWA@1117|Cyanobacteria,1HF6Y@1150|Oscillatoriales	1117|Cyanobacteria	S	Late control gene D protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3864362_0	316274.Haur_1779	3.421e-84	306.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	Dam,PhageMin_Tail
CMS1_k127_3864528_1	264462.Bd0808	2.542e-206	655.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2MSV6@213481|Bdellovibrionales,2WJ0F@28221|Deltaproteobacteria	213481|Bdellovibrionales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
CMS1_k127_3864528_2	889378.Spiaf_2232	1.197e-14	79.0	291RI@1|root,2ZPBI@2|Bacteria,2J8IP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3864528_0	716544.wcw_0172	3.261e-222	710.0	COG2183@1|root,COG2183@2|Bacteria,2JFI3@204428|Chlamydiae	204428|Chlamydiae	K	Tex-like protein N-terminal domain	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
CMS1_k127_3866796_2	1380384.JADN01000004_gene2029	1.59e-24	106.0	COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,1HX1V@117743|Flavobacteriia	976|Bacteroidetes	M	penicillin-binding protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
CMS1_k127_3866796_1	1086011.HJ01_03198	7.319e-28	115.0	2CFVU@1|root,3373K@2|Bacteria,4NY6U@976|Bacteroidetes,1ID3F@117743|Flavobacteriia,2NX5E@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3866796_0	865937.Gilli_0456	2.034e-79	268.0	28N47@1|root,2ZB9Q@2|Bacteria,4NMNP@976|Bacteroidetes,1I1SS@117743|Flavobacteriia,2P6Z7@244698|Gillisia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3868413_0	1107311.Q767_01120	2.046e-82	279.0	COG3842@1|root,COG3842@2|Bacteria,4NEZ6@976|Bacteroidetes,1HXA2@117743|Flavobacteriia,2NT47@237|Flavobacterium	976|Bacteroidetes	E	ABC transporter, ATP-binding protein	fbpC2	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
CMS1_k127_3868413_1	1121904.ARBP01000008_gene3226	8.14e-55	209.0	COG4251@1|root,COG4251@2|Bacteria,4PN0E@976|Bacteroidetes,47YPJ@768503|Cytophagia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,TPR_12,TPR_8
CMS1_k127_3872697_0	880073.Calab_2577	2.746e-42	166.0	COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria	2|Bacteria	KT	COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	CBS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE,dCache_1
CMS1_k127_3877282_2	1347368.HG964404_gene5470	5.157e-11	68.0	2ETXP@1|root,33J3D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3877282_0	1227352.C173_14070	4.125e-21	100.0	COG3064@1|root,COG3064@2|Bacteria,1U0N2@1239|Firmicutes,4IA20@91061|Bacilli,270XJ@186822|Paenibacillaceae	91061|Bacilli	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3877282_1	1141662.OOA_02017	4.743e-12	74.0	COG3210@1|root,COG3210@2|Bacteria,1P50E@1224|Proteobacteria,1STNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_387988_0	1123274.KB899419_gene1998	1.641e-50	184.0	2C5UX@1|root,33TSC@2|Bacteria,2J5VA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_387988_1	1173021.ALWA01000001_gene2306	2.188e-44	164.0	COG0432@1|root,COG0432@2|Bacteria,1G61Z@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
CMS1_k127_387988_2	1289135.A966_01903	3.74e-32	136.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS1_k127_387988_4	582515.KR51_00007690	4.923e-16	86.0	COG0500@1|root,COG2226@2|Bacteria,1G3V3@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
CMS1_k127_387988_3	525919.Apre_1270	4.224e-20	98.0	COG0151@1|root,COG0151@2|Bacteria,1TRZ2@1239|Firmicutes,2497Y@186801|Clostridia,22FXJ@1570339|Peptoniphilaceae	186801|Clostridia	F	ATP-grasp domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4,GARS_A
CMS1_k127_3898920_1	926561.KB900617_gene1910	5.393e-140	471.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3372,PUD
CMS1_k127_3898920_0	1289135.A966_01166	9.327e-204	642.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
CMS1_k127_3901831_0	889378.Spiaf_0836	1.078e-50	190.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_3901831_4	526224.Bmur_2321	5.027e-15	85.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2J58Z@203691|Spirochaetes	203691|Spirochaetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
CMS1_k127_3901831_2	1178537.BA1_11459	1.236e-36	159.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,1ZBEA@1386|Bacillus	91061|Bacilli	NT	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
CMS1_k127_3901831_1	1123354.AUDR01000015_gene453	2.545e-47	175.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2VQ2J@28216|Betaproteobacteria,1KRN4@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
CMS1_k127_3901831_3	1041504.RATSFB_0972	1.247e-16	91.0	2E81I@1|root,332FK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_390397_1	935948.KE386495_gene1079	1.699e-81	276.0	COG2730@1|root,COG2730@2|Bacteria,1TQUA@1239|Firmicutes,248Y8@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	celC	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
CMS1_k127_390397_0	1048983.EL17_15410	4.74e-110	369.0	COG3291@1|root,COG3291@2|Bacteria,4PKMJ@976|Bacteroidetes,47JGW@768503|Cytophagia	976|Bacteroidetes	G	Cellulase N-terminal ig-like domain	-	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0033946,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0052736,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CelD_N,Glyco_hydro_9
CMS1_k127_3908181_0	1173024.KI912150_gene1283	1.19e-163	550.0	COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1GHDU@1117|Cyanobacteria,1JKFU@1189|Stigonemataceae	1117|Cyanobacteria	Q	Lamin Tail Domain	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Calx-beta,Exo_endo_phos,HemolysinCabind,LTD
CMS1_k127_3908181_1	1170562.Cal6303_2841	2.426e-131	437.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1G0YK@1117|Cyanobacteria,1HJQH@1161|Nostocales	1117|Cyanobacteria	Q	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,CHRD,DUF4114,DUF4214,Exo_endo_phos,Phytase-like,W_rich_C
CMS1_k127_3912886_2	573061.Clocel_3647	2.853e-11	67.0	2EBR1@1|root,335QY@2|Bacteria,1VHT3@1239|Firmicutes,25DTY@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3912886_0	1408473.JHXO01000009_gene3474	6.09e-28	119.0	2E6GM@1|root,3313V@2|Bacteria,4NT39@976|Bacteroidetes,2FZCY@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_3912886_3	1078085.HMPREF1210_02086	3.668e-09	62.0	COG1476@1|root,COG1476@2|Bacteria,1VEKB@1239|Firmicutes,4HNIW@91061|Bacilli	91061|Bacilli	K	Transcriptional	ansR1	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
CMS1_k127_3912886_1	1168067.JAGP01000001_gene1608	2.06e-15	79.0	COG0443@1|root,COG5635@1|root,COG0443@2|Bacteria,COG5635@2|Bacteria,1QWD1@1224|Proteobacteria	1224|Proteobacteria	T	Heat shock 70 kDa protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,TIR_2
CMS1_k127_3914194_3	1121087.AUCK01000031_gene3079	6.79e-13	76.0	COG2137@1|root,COG2137@2|Bacteria,1V72V@1239|Firmicutes,4HJ7R@91061|Bacilli,1ZC8N@1386|Bacillus	91061|Bacilli	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
CMS1_k127_3914194_0	398512.JQKC01000033_gene4990	3.206e-252	805.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,3WGEX@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
CMS1_k127_3914194_1	796606.BMMGA3_13495	2.929e-68	245.0	COG0726@1|root,COG0726@2|Bacteria,1TWQ0@1239|Firmicutes,4HD9K@91061|Bacilli,1ZFFG@1386|Bacillus	91061|Bacilli	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS1_k127_3914194_2	1410609.JHVB01000003_gene315	1.213e-16	91.0	COG4254@1|root,COG4254@2|Bacteria,2J772@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS1_k127_3914727_0	926561.KB900617_gene1356	3.661e-47	186.0	COG0366@1|root,COG1404@1|root,COG0366@2|Bacteria,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,3WB04@53433|Halanaerobiales	186801|Clostridia	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	ko:K14645,ko:K20486	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,Peptidase_S8
CMS1_k127_3914727_1	1499967.BAYZ01000026_gene1643	9.416e-14	76.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Peptidase_C39,RHS_repeat
CMS1_k127_3917266_0	1307761.L21SP2_1771	1.284e-152	503.0	COG0568@1|root,COG0568@2|Bacteria,2J59P@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
CMS1_k127_3917266_1	883103.HMPREF9703_01285	5.891e-20	99.0	COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,4HAXW@91061|Bacilli,27FCH@186828|Carnobacteriaceae	91061|Bacilli	I	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	gpsA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0047952,GO:0055114	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
CMS1_k127_3918199_7	1150474.JQJI01000046_gene1493	7.002e-18	89.0	COG0779@1|root,COG0779@2|Bacteria,2GD7P@200918|Thermotogae	200918|Thermotogae	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
CMS1_k127_3918199_2	744872.Spica_1353	2.809e-100	342.0	COG0195@1|root,COG0195@2|Bacteria,2J624@203691|Spirochaetes	203691|Spirochaetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1,zf-ribbon_3
CMS1_k127_3918199_1	573413.Spirs_2028	8.234e-228	730.0	COG0532@1|root,COG0532@2|Bacteria,2J692@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
CMS1_k127_3918199_6	457570.Nther_1445	1.86e-24	106.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
CMS1_k127_3918199_4	1292035.H476_1652	2.414e-52	196.0	COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia,25QIQ@186804|Peptostreptococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
CMS1_k127_3918199_5	246194.CHY_1760	4.743e-32	126.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,42GTG@68295|Thermoanaerobacterales	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
CMS1_k127_3918199_0	498761.HM1_2322	8.135e-229	727.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
CMS1_k127_3918199_3	1122915.AUGY01000027_gene3477	4.157e-100	338.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,4HBBF@91061|Bacilli,26SAI@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the peptidase M16 family	mlpA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
CMS1_k127_3918580_6	1286171.EAL2_c12950	2.071e-20	92.0	COG1923@1|root,COG1923@2|Bacteria,1VEGI@1239|Firmicutes,24QIM@186801|Clostridia	186801|Clostridia	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
CMS1_k127_3918580_0	1444309.JAQG01000029_gene2450	6.741e-68	242.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,4HAVW@91061|Bacilli,26RAP@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
CMS1_k127_3918580_2	648996.Theam_1402	4.778e-51	187.0	COG0194@1|root,COG0194@2|Bacteria,2G3ZQ@200783|Aquificae	200783|Aquificae	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
CMS1_k127_3918580_5	469381.Dpep_2334	9.897e-26	108.0	COG2052@1|root,COG2052@2|Bacteria,3TBDT@508458|Synergistetes	508458|Synergistetes	S	Belongs to the UPF0296 family	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
CMS1_k127_3918580_3	744872.Spica_1578	1.104e-45	176.0	COG1561@1|root,COG1561@2|Bacteria,2J76C@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TIGR00255 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
CMS1_k127_3918580_4	293826.Amet_2695	1.692e-45	169.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia,36I61@31979|Clostridiaceae	186801|Clostridia	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
CMS1_k127_3918580_1	443144.GM21_2618	4.01e-59	216.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR-1	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg
CMS1_k127_3935564_3	688270.Celal_3252	9.138e-07	59.0	COG4886@1|root,COG4886@2|Bacteria,4NR6Y@976|Bacteroidetes,1I2WF@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Receptor L domain	-	-	-	-	-	-	-	-	-	-	-	-	ASH
CMS1_k127_3935564_2	1121405.dsmv_2347	7.262e-18	85.0	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2WJPG@28221|Deltaproteobacteria,2MI4A@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
CMS1_k127_3935564_1	573061.Clocel_1208	8.91e-21	94.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	1.8.1.9	ko:K00384,ko:K01420	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000	-	-	-	Pyr_redox_2,Pyr_redox_3,cNMP_binding
CMS1_k127_3935564_0	398511.BpOF4_05760	7.391e-109	361.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,1ZBA4@1386|Bacillus	91061|Bacilli	E	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
CMS1_k127_3936093_4	697303.Thewi_0452	8.939e-25	105.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,42EMC@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS1_k127_3936093_1	2325.TKV_c03330	2.594e-121	397.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
CMS1_k127_3936093_3	1168034.FH5T_02985	4.436e-39	149.0	COG0824@1|root,COG0824@2|Bacteria,4NSJR@976|Bacteroidetes,2FS2E@200643|Bacteroidia	976|Bacteroidetes	S	acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
CMS1_k127_3936093_0	795359.TOPB45_1456	1.42e-154	502.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GH4Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
CMS1_k127_3936093_2	696281.Desru_0629	1.523e-59	211.0	COG3871@1|root,COG3871@2|Bacteria,1V1KZ@1239|Firmicutes,25CPA@186801|Clostridia,261T5@186807|Peptococcaceae	186801|Clostridia	S	PFAM pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx,Pyrid_ox_like
CMS1_k127_3946093_0	1173027.Mic7113_4041	4.976e-87	319.0	COG0515@1|root,COG2114@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,Guanylate_cyc,HATPase_c,HisKA,PAS_4,Pkinase,Response_reg
CMS1_k127_3972561_3	204669.Acid345_3014	2.368e-101	359.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia	204432|Acidobacteriia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
CMS1_k127_3972561_4	743719.PaelaDRAFT_3774	5.035e-21	109.0	COG3292@1|root,COG5184@1|root,COG5520@1|root,COG3292@2|Bacteria,COG5184@2|Bacteria,COG5520@2|Bacteria,1UZD4@1239|Firmicutes,4HD48@91061|Bacilli,26VBQ@186822|Paenibacillaceae	91061|Bacilli	DZ	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,RCC1_2,SLH
CMS1_k127_3972561_2	926561.KB900617_gene1902	4.651e-121	417.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	VCBS,fn3
CMS1_k127_3972561_0	926561.KB900617_gene1901	2.132e-264	861.0	COG0366@1|root,COG0366@2|Bacteria,1V0U1@1239|Firmicutes,24ZQ4@186801|Clostridia	1239|Firmicutes	G	Alpha amylase, catalytic domain	aml1	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CBM53,CBM_35,CHB_HEX_C_1
CMS1_k127_3972561_5	1121289.JHVL01000001_gene1871	7.15e-05	55.0	COG2206@1|root,COG2206@2|Bacteria,1TR95@1239|Firmicutes,25AZS@186801|Clostridia,36ECN@31979|Clostridiaceae	186801|Clostridia	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
CMS1_k127_3972561_1	926561.KB900617_gene1905	2.305e-186	624.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,Big_2,CBM_20,CBM_48,PUD
CMS1_k127_3976886_2	1122201.AUAZ01000014_gene292	6.034e-22	100.0	COG0662@1|root,COG0662@2|Bacteria,1NX67@1224|Proteobacteria,1SQGE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
CMS1_k127_3976886_1	999541.bgla_2g12020	3.121e-79	271.0	COG1409@1|root,COG1409@2|Bacteria,1R70J@1224|Proteobacteria,2WCJ4@28216|Betaproteobacteria,1K7YY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS1_k127_3976886_0	1223521.BBJX01000001_gene853	1.664e-85	302.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4ABH4@80864|Comamonadaceae	28216|Betaproteobacteria	NT	Chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_3,dCache_2,sCache_2
CMS1_k127_3976886_3	1219065.VPR01S_11_01470	1.566e-10	66.0	COG0454@1|root,COG0456@2|Bacteria,1RHB7@1224|Proteobacteria,1S3TD@1236|Gammaproteobacteria,1XVUK@135623|Vibrionales	135623|Vibrionales	K	L-2,4-diaminobutyric acid acetyltransferase	ectA	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016407,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019491,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0042399,GO:0043170,GO:0043412,GO:0043436,GO:0043543,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.3.1.178	ko:K06718	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06978	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
CMS1_k127_398372_0	573413.Spirs_0166	0.0	1030.0	COG0620@1|root,COG0620@2|Bacteria,2J6A2@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
CMS1_k127_398372_1	1031288.AXAA01000005_gene2065	3.081e-17	82.0	COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes	1239|Firmicutes	D	cluster protein-associated redox disulfide domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
CMS1_k127_398372_2	381046.XP_002551634.1	3.465e-08	61.0	KOG3986@1|root,KOG3986@2759|Eukaryota,38C5W@33154|Opisthokonta,3Q38C@4751|Fungi,3RK9T@4890|Ascomycota,3RSJH@4891|Saccharomycetes,3S0VR@4893|Saccharomycetaceae	4751|Fungi	OT	to Saccharomyces cerevisiae GIP2 (YER054C) and PIG2 (YIL045W)	-	GO:0000164,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005979,GO:0006073,GO:0006091,GO:0006109,GO:0006112,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008287,GO:0009889,GO:0009987,GO:0010556,GO:0010675,GO:0010906,GO:0010921,GO:0010962,GO:0015980,GO:0016311,GO:0019208,GO:0019220,GO:0019222,GO:0019538,GO:0019888,GO:0030234,GO:0031323,GO:0031326,GO:0031399,GO:0032268,GO:0032881,GO:0032885,GO:0032991,GO:0035303,GO:0035304,GO:0036211,GO:0043170,GO:0043255,GO:0043412,GO:0043467,GO:0043666,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051174,GO:0051246,GO:0051336,GO:0055114,GO:0060255,GO:0062012,GO:0065007,GO:0065009,GO:0070873,GO:0071704,GO:0080090,GO:0098772,GO:1901564,GO:1902494,GO:1903293,GO:2000112	-	-	-	-	-	-	-	-	-	-	CBM_21
CMS1_k127_3990483_0	643648.Slip_0400	1.536e-67	243.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,42JQW@68298|Syntrophomonadaceae	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
CMS1_k127_3990483_2	1321774.HMPREF9108_01738	1.165e-29	123.0	COG1051@1|root,COG1051@2|Bacteria,37ASE@32066|Fusobacteria	32066|Fusobacteria	F	Hydrolase, NUDIX family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS1_k127_3990483_1	412419.BDU_707	1.254e-66	236.0	COG0571@1|root,COG0571@2|Bacteria,2J6UI@203691|Spirochaetes	203691|Spirochaetes	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
CMS1_k127_3990483_3	1123504.JQKD01000022_gene101	6.383e-12	68.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2VTZH@28216|Betaproteobacteria,4AF2T@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
CMS1_k127_3990483_4	1267533.KB906734_gene4285	6.318e-05	45.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria,2JNN2@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal L32p protein family	-	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
CMS1_k127_3992925_8	515622.bpr_I0101	1.141e-49	185.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,4BXDR@830|Butyrivibrio	186801|Clostridia	M	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
CMS1_k127_3992925_9	572479.Hprae_0954	1.149e-33	140.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,3WA88@53433|Halanaerobiales	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
CMS1_k127_3992925_4	1246995.AFR_14970	4.124e-113	379.0	COG1874@1|root,COG1874@2|Bacteria,2GNR4@201174|Actinobacteria,4DC36@85008|Micromonosporales	201174|Actinobacteria	G	Domain of unknown function (DUF4832)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832
CMS1_k127_3992925_3	1246995.AFR_14970	1.391e-113	382.0	COG1874@1|root,COG1874@2|Bacteria,2GNR4@201174|Actinobacteria,4DC36@85008|Micromonosporales	201174|Actinobacteria	G	Domain of unknown function (DUF4832)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832
CMS1_k127_3992925_0	1499967.BAYZ01000054_gene4828	6.199e-219	695.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	ywjA	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
CMS1_k127_3992925_1	926561.KB900617_gene1911	7.439e-122	408.0	COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria	2|Bacteria	G	belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	AMPK1_CBM,Alpha-amylase,Big_5,CBM_48,CHB_HEX_C_1,DUF3372,PUD
CMS1_k127_3992925_7	316067.Geob_3430	2.821e-53	200.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
CMS1_k127_3992925_2	237368.SCABRO_02979	8.112e-116	391.0	COG0348@1|root,COG1143@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,2IZ24@203682|Planctomycetes	203682|Planctomycetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
CMS1_k127_3992925_6	526218.Sterm_2025	1.374e-57	207.0	COG2949@1|root,COG2949@2|Bacteria,37B44@32066|Fusobacteria	32066|Fusobacteria	S	DUF218 domain	-	-	-	ko:K03748	-	-	-	-	ko00000	-	-	-	DUF218
CMS1_k127_3992925_10	1121946.AUAX01000011_gene4089	2.154e-10	74.0	COG2273@1|root,COG2273@2|Bacteria,2GKFN@201174|Actinobacteria,4DH60@85008|Micromonosporales	201174|Actinobacteria	G	Hydrolase Family 16	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,F5_F8_type_C
CMS1_k127_3992925_5	933262.AXAM01000059_gene2904	1.434e-109	380.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2MIVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
CMS1_k127_3995502_1	32057.KB217478_gene1508	4.439e-27	131.0	COG1572@1|root,COG1572@2|Bacteria,1GE0K@1117|Cyanobacteria,1HRW1@1161|Nostocales	1117|Cyanobacteria	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS1_k127_3995502_0	28072.Nos7524_5161	5.814e-72	261.0	COG0641@1|root,COG0641@2|Bacteria,1FZZY@1117|Cyanobacteria,1HRV7@1161|Nostocales	1117|Cyanobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_3997338_0	331678.Cphamn1_1711	7.405e-14	86.0	COG0823@1|root,COG0823@2|Bacteria,1FEIQ@1090|Chlorobi	1090|Chlorobi	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
CMS1_k127_4016875_5	318464.IO99_04880	7.291e-05	53.0	COG0791@1|root,COG0791@2|Bacteria,1TSZ0@1239|Firmicutes,25B1S@186801|Clostridia,36WBR@31979|Clostridiaceae	186801|Clostridia	M	NlpC/P60 family	-	-	3.4.14.13	ko:K20742	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	3D,NLPC_P60,SH3_3
CMS1_k127_4016875_2	1293054.HSACCH_00281	4.871e-47	190.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
CMS1_k127_4016875_0	1123276.KB893245_gene1245	1.604e-102	344.0	COG2603@1|root,COG2603@2|Bacteria,4NH7W@976|Bacteroidetes,47KFW@768503|Cytophagia	976|Bacteroidetes	S	Rhodanese Homology Domain	-	-	-	ko:K06917	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Rhodanese
CMS1_k127_4016875_1	485916.Dtox_3828	2.213e-96	327.0	COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,249F8@186801|Clostridia,264CT@186807|Peptococcaceae	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	-	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
CMS1_k127_4016875_3	889378.Spiaf_2163	1.224e-37	146.0	COG1162@1|root,COG1162@2|Bacteria	2|Bacteria	S	GTPase activity	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	Acetyltransf_1,RNHCP,RsgA_GTPase,RsgA_N
CMS1_k127_4016875_4	316274.Haur_3955	1.388e-10	64.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31,Peptidase_M78,UPF0175
CMS1_k127_4050617_0	889378.Spiaf_2521	2.671e-154	533.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	malS	-	2.1.1.72,3.1.4.46,3.2.1.1	ko:K00571,ko:K01126,ko:K01176	ko00500,ko00564,ko01100,ko04973,map00500,map00564,map01100,map04973	-	R01030,R01470,R02108,R02112,R11262	RC00017,RC00425	ko00000,ko00001,ko01000,ko02048	-	GH13	-	Alpha-amylase,CBM26
CMS1_k127_4050617_1	880074.BARVI_03915	7.504e-73	260.0	COG3328@1|root,COG3328@2|Bacteria,4NY5M@976|Bacteroidetes,2FTUC@200643|Bacteroidia	976|Bacteroidetes	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
CMS1_k127_4050888_4	1353276.JADR01000010_gene1648	7.035e-09	57.0	COG3931@1|root,COG3931@2|Bacteria,4NMA3@976|Bacteroidetes,1I1FX@117743|Flavobacteriia	976|Bacteroidetes	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
CMS1_k127_4050888_1	1232410.KI421415_gene2974	7.731e-124	409.0	COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,42PBG@68525|delta/epsilon subdivisions,2WK4S@28221|Deltaproteobacteria,43UJW@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Glutamate-cysteine ligase family 2(GCS2)	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
CMS1_k127_4050888_0	1304885.AUEY01000004_gene946	1.031e-175	563.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria,2MN7D@213118|Desulfobacterales	28221|Deltaproteobacteria	HJ	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK
CMS1_k127_4050888_2	1304885.AUEY01000004_gene947	5.763e-84	284.0	COG3271@1|root,COG3271@2|Bacteria,1RAD5@1224|Proteobacteria,42QWA@68525|delta/epsilon subdivisions,2WMVM@28221|Deltaproteobacteria,2MNBG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39,Peptidase_C39_2
CMS1_k127_4050888_3	526224.Bmur_0247	4.212e-14	76.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
CMS1_k127_4057743_1	404380.Gbem_0694	1.608e-07	62.0	COG1361@1|root,COG1729@1|root,COG3064@1|root,COG1361@2|Bacteria,COG1729@2|Bacteria,COG3064@2|Bacteria,1NCIT@1224|Proteobacteria,431YH@68525|delta/epsilon subdivisions,2WWR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	AMIN,TPR_6
CMS1_k127_4057743_0	1345695.CLSA_c20470	3.385e-09	61.0	COG1406@1|root,COG1406@2|Bacteria,1VD18@1239|Firmicutes,24HMR@186801|Clostridia,36ING@31979|Clostridiaceae	186801|Clostridia	N	Chemotaxis protein CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
CMS1_k127_4061206_2	378806.STAUR_8013	1.7e-20	98.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NYYU@1224|Proteobacteria	1224|Proteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS1_k127_4061206_0	926561.KB900623_gene1012	1.287e-152	498.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,3WAAC@53433|Halanaerobiales	186801|Clostridia	O	chelatase, subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
CMS1_k127_4061206_1	390874.Tpet_0419	9.005e-103	343.0	COG0444@1|root,COG0444@2|Bacteria,2GCKF@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
CMS1_k127_4061206_3	1150474.JQJI01000008_gene1349	3.278e-10	67.0	COG1409@1|root,COG1409@2|Bacteria,2GDWS@200918|Thermotogae	200918|Thermotogae	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
CMS1_k127_4063533_0	243274.THEMA_04115	2.165e-155	499.0	COG0133@1|root,COG0133@2|Bacteria,2GEGC@200918|Thermotogae	200918|Thermotogae	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS1_k127_4063533_7	926561.KB900620_gene2993	6.902e-36	143.0	COG0135@1|root,COG0135@2|Bacteria,1V6Y0@1239|Firmicutes,24HBQ@186801|Clostridia,3WBXQ@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
CMS1_k127_4063533_6	639282.DEFDS_0441	1.3e-45	175.0	COG0134@1|root,COG0134@2|Bacteria,2GFHG@200930|Deferribacteres	200930|Deferribacteres	E	Indole-3-glycerol phosphate synthase	-	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
CMS1_k127_4063533_4	684719.HIMB114_00005740	2.547e-73	258.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,4BP88@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
CMS1_k127_4063533_5	986075.CathTA2_0204	7.461e-57	203.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,4H9XP@91061|Bacilli	91061|Bacilli	EH	with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine	pabA	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01664	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	iYO844.BSU00750	GATase
CMS1_k127_4063533_3	1158338.JNLJ01000001_gene802	2.605e-97	336.0	COG0147@1|root,COG0147@2|Bacteria,2G3NV@200783|Aquificae	200783|Aquificae	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
CMS1_k127_4063533_8	118166.JH976537_gene1386	4.168e-12	74.0	COG1943@1|root,COG1943@2|Bacteria,1G38T@1117|Cyanobacteria,1HACX@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CMS1_k127_4063533_1	1121097.JCM15093_2296	1.37e-105	349.0	COG1179@1|root,COG1179@2|Bacteria,4NEKB@976|Bacteroidetes,2FMG4@200643|Bacteroidia,4AP24@815|Bacteroidaceae	976|Bacteroidetes	H	involved in molybdopterin and thiamine biosynthesis family 1	hypB	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
CMS1_k127_4063533_9	744872.Spica_2767	6.219e-05	47.0	28ZMA@1|root,2ZMCJ@2|Bacteria,2JB7Z@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4063533_2	796606.BMMGA3_09025	2.369e-98	346.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1ZAVY@1386|Bacillus	91061|Bacilli	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_9
CMS1_k127_4067704_6	113355.CM001775_gene4057	1.329e-14	83.0	COG1216@1|root,COG1216@2|Bacteria,1G2MT@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
CMS1_k127_4067704_2	404380.Gbem_1075	1.819e-59	217.0	COG1215@1|root,COG1215@2|Bacteria,1R4ZM@1224|Proteobacteria,42T5P@68525|delta/epsilon subdivisions,2WPSG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_4067704_7	1046714.AMRX01000006_gene2788	4.083e-12	79.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,rhaM
CMS1_k127_4067704_1	247490.KSU1_C0002	6.514e-106	362.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2J0AY@203682|Planctomycetes	203682|Planctomycetes	D	Capsular exopolysaccharide family	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,Wzz
CMS1_k127_4067704_9	1452535.JARD01000018_gene2731	0.0002837	53.0	2CD7Z@1|root,30EQS@2|Bacteria,2GNGQ@201174|Actinobacteria,4FNRW@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4067704_4	272562.CA_C2320	5.864e-40	160.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,25KDC@186801|Clostridia,36GZN@31979|Clostridiaceae	186801|Clostridia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
CMS1_k127_4067704_5	572479.Hprae_2090	7.145e-24	106.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia	186801|Clostridia	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
CMS1_k127_4067704_3	1449049.JONW01000006_gene2855	4.43e-45	177.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria,2UK9W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4067704_0	489825.LYNGBM3L_09400	2.615e-126	423.0	COG1696@1|root,COG1696@2|Bacteria,1G2RR@1117|Cyanobacteria,1H9BT@1150|Oscillatoriales	1117|Cyanobacteria	M	membrane protein involved in D-alanine export	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
CMS1_k127_4067704_8	1170562.Cal6303_0161	1.528e-11	68.0	COG2755@1|root,COG2755@2|Bacteria,1G3CB@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM GDSL-like Lipase Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
CMS1_k127_4070979_3	744872.Spica_1442	2.203e-07	61.0	2CK99@1|root,3464J@2|Bacteria,2J60S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4070979_1	351627.Csac_1039	1.328e-67	249.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,42EWB@68295|Thermoanaerobacterales	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
CMS1_k127_4070979_0	909663.KI867150_gene1865	7.751e-173	560.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2MSIG@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC transporter	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
CMS1_k127_4070979_2	382464.ABSI01000010_gene3441	1.803e-50	188.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia,2IUBG@203494|Verrucomicrobiae	74201|Verrucomicrobia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS1_k127_4072972_0	1414720.CBYM010000006_gene1272	2.25e-24	119.0	COG2199@1|root,COG2199@2|Bacteria,1VQTU@1239|Firmicutes,24D8M@186801|Clostridia,36GZE@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_4083591_1	56780.SYN_02195	2.287e-51	188.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42QSV@68525|delta/epsilon subdivisions,2WMZ5@28221|Deltaproteobacteria,2MRRW@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Telomere recombination	yrdC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
CMS1_k127_4083591_0	1158318.ATXC01000001_gene28	1.14e-115	392.0	COG1031@1|root,COG1031@2|Bacteria	2|Bacteria	C	metal cluster binding	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	HHH,HHH_3,Radical_SAM
CMS1_k127_4083591_3	1232437.KL662015_gene1252	2.855e-26	115.0	COG1418@1|root,COG1418@2|Bacteria,1RJ5H@1224|Proteobacteria,42SFF@68525|delta/epsilon subdivisions,2WP85@28221|Deltaproteobacteria,2MK90@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS1_k127_4083591_2	1121289.JHVL01000021_gene790	1.721e-35	138.0	28NR9@1|root,2ZBQJ@2|Bacteria,1UZEN@1239|Firmicutes,24G0V@186801|Clostridia,36I0Y@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4085333_2	907348.TresaDRAFT_0154	1.988e-24	106.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS1_k127_4085333_3	1123073.KB899243_gene729	5.826e-07	61.0	COG1652@1|root,COG1652@2|Bacteria,1RD8K@1224|Proteobacteria,1SGZZ@1236|Gammaproteobacteria,1XC0C@135614|Xanthomonadales	135614|Xanthomonadales	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
CMS1_k127_4085333_0	237368.SCABRO_02223	7.23e-117	384.0	COG0714@1|root,COG0714@2|Bacteria,2IX23@203682|Planctomycetes	203682|Planctomycetes	S	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
CMS1_k127_4085333_1	991.IW20_01035	1.304e-35	139.0	COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,1HX4X@117743|Flavobacteriia,2NSFG@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS1_k127_4088999_2	909663.KI867150_gene2613	0.0003328	44.0	COG1475@1|root,COG1475@2|Bacteria,1NGPB@1224|Proteobacteria,42XFK@68525|delta/epsilon subdivisions,2WTFN@28221|Deltaproteobacteria,2MS69@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
CMS1_k127_4088999_3	75379.Tint_2783	0.0005903	52.0	COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,2VPK0@28216|Betaproteobacteria,1KM9A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_N,Mrr_cat
CMS1_k127_4088999_1	1313265.JNIE01000005_gene269	1.709e-06	61.0	COG0457@1|root,COG0457@2|Bacteria,2G407@200783|Aquificae	200783|Aquificae	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
CMS1_k127_4088999_0	526224.Bmur_0199	6.024e-21	96.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	ttg2E	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043856,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	3.5.1.2	ko:K01425,ko:K02066,ko:K03090,ko:K04749,ko:K06378,ko:K07122	ko00220,ko00250,ko00471,ko01100,ko02010,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map02010,map04724,map04727,map04964,map05206,map05230	M00210,M00669,M00670	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko00002,ko01000,ko02000,ko03021	3.A.1.27,3.A.1.27.3	-	-	MEDS,STAS,STAS_2
CMS1_k127_4090489_0	907348.TresaDRAFT_1929	7.268e-106	363.0	COG0366@1|root,COG0366@2|Bacteria,2J9X3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_4093557_4	1316932.MHH_c15140	3.317e-50	188.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1Y6ZR@135625|Pasteurellales	135625|Pasteurellales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD2	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
CMS1_k127_4093557_1	517417.Cpar_2011	3.561e-172	550.0	COG0161@1|root,COG0161@2|Bacteria,1FDPN@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
CMS1_k127_4093557_3	1267535.KB906767_gene1733	1.824e-137	445.0	COG0016@1|root,COG0016@2|Bacteria,3Y3NJ@57723|Acidobacteria,2JIN8@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
CMS1_k127_4093557_2	1291050.JAGE01000001_gene2735	1.008e-157	526.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,3WHBB@541000|Ruminococcaceae	186801|Clostridia	J	phenylalanyl-tRNA synthetase (beta subunit)	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
CMS1_k127_4093557_0	485915.Dret_1767	1.019e-203	648.0	COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2WJZA@28221|Deltaproteobacteria,2M9HI@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
CMS1_k127_4093557_5	673860.AciM339_0412	3.889e-38	149.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,3F3BY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM adenylyl cyclase CyaB	cyaB	GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
CMS1_k127_4093557_6	889378.Spiaf_1973	7.745e-14	74.0	COG5401@1|root,COG5401@2|Bacteria,2J7JQ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
CMS1_k127_4112763_3	247490.KSU1_D0598	2.78e-24	108.0	COG2199@1|root,COG3706@2|Bacteria,2J108@203682|Planctomycetes	203682|Planctomycetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS1_k127_4112763_0	402880.MmarC5_1496	0.0	1122.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,23QPM@183939|Methanococci	183939|Methanococci	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
CMS1_k127_4112763_2	267377.MMP0178	2.998e-91	307.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,23QEB@183939|Methanococci	183939|Methanococci	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
CMS1_k127_4112763_1	509191.AEDB02000003_gene1043	6.541e-120	400.0	COG2199@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5002@2|Bacteria,1UVSG@1239|Firmicutes,24B7R@186801|Clostridia	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_4115203_2	498761.HM1_0145	3.976e-22	111.0	COG4733@1|root,COG5492@1|root,COG4733@2|Bacteria,COG5492@2|Bacteria,1UHXK@1239|Firmicutes,25E6U@186801|Clostridia	186801|Clostridia	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_X2,Flg_new,I-set,Laminin_G_3,SLH
CMS1_k127_4115203_3	1218103.CIN01S_04_02950	4.246e-09	69.0	COG1404@1|root,COG3250@1|root,COG3325@1|root,COG1404@2|Bacteria,COG3250@2|Bacteria,COG3325@2|Bacteria,4NGXK@976|Bacteroidetes,1I36R@117743|Flavobacteriia,3ZRIG@59732|Chryseobacterium	976|Bacteroidetes	G	Glycosyl hydrolases family 18	endOF1	-	-	-	-	-	-	-	-	-	-	-	DUF1735,Glyco_hydro_18,Laminin_G_3,fn3
CMS1_k127_4115203_0	573061.Clocel_0017	8.525e-43	171.0	COG4076@1|root,COG4076@2|Bacteria,1UKYK@1239|Firmicutes,24FFX@186801|Clostridia,36F4F@31979|Clostridiaceae	186801|Clostridia	Q	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4115203_1	755732.Fluta_0086	1.098e-40	163.0	COG0223@1|root,COG0223@2|Bacteria,4NT42@976|Bacteroidetes,1I7ZR@117743|Flavobacteriia	976|Bacteroidetes	J	Formyl transferase, C-terminal domain	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
CMS1_k127_4115203_4	1145276.T479_09045	0.0003982	46.0	COG4675@1|root,COG4675@2|Bacteria,1V6CH@1239|Firmicutes,4HK20@91061|Bacilli,3IZPV@400634|Lysinibacillus	91061|Bacilli	S	Phage Tail Collar Domain	-	-	-	-	-	-	-	-	-	-	-	-	Collar
CMS1_k127_4120872_1	1167006.UWK_02249	3.799e-17	93.0	COG4856@1|root,COG4856@2|Bacteria,1REEU@1224|Proteobacteria,42RY2@68525|delta/epsilon subdivisions,2WNZH@28221|Deltaproteobacteria,2MIQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
CMS1_k127_4120872_0	754436.JCM19237_4466	5.782e-76	261.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1XTR0@135623|Vibrionales	135623|Vibrionales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
CMS1_k127_4128078_2	1121904.ARBP01000002_gene7136	4.427e-60	213.0	COG0637@1|root,COG0637@2|Bacteria,4NEEH@976|Bacteroidetes,47RK3@768503|Cytophagia	976|Bacteroidetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
CMS1_k127_4128078_1	28072.Nos7524_1599	3.345e-159	514.0	COG1012@1|root,COG1012@2|Bacteria,1G2U1@1117|Cyanobacteria,1HIJT@1161|Nostocales	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.5	ko:K00128,ko:K00129	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00350,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00980,ko00981,ko00982,ko01100,ko01110,ko01120,ko01130,ko05204,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00903,map00980,map00981,map00982,map01100,map01110,map01120,map01130,map05204	M00135	R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02536,R02537,R02549,R02678,R02695,R02697,R02940,R02957,R03283,R03300,R03302,R03869,R04065,R04506,R04882,R04883,R04888,R04889,R04891,R04892,R04903,R04996,R05050,R05237,R05238,R05286,R06366,R07104,R08146,R08282,R08283,R08307	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500,RC01735	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS1_k127_4128078_0	909663.KI867150_gene133	4.897e-191	634.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria,2MQWD@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Exodeoxyribonuclease V, gamma subunit	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
CMS1_k127_4145183_0	1220534.B655_2185	2.624e-41	174.0	COG1520@1|root,arCOG02492@2157|Archaea,2Y7Q0@28890|Euryarchaeota,23PZ1@183925|Methanobacteria	183925|Methanobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
CMS1_k127_4149339_0	247490.KSU1_C0538	1.222e-139	449.0	COG1741@1|root,COG1741@2|Bacteria,2IXVU@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
CMS1_k127_4149339_1	109760.SPPG_01685T0	1.088e-12	72.0	COG0421@1|root,COG2940@1|root,KOG1081@2759|Eukaryota,KOG1562@2759|Eukaryota	2759|Eukaryota	E	spermidine synthase activity	SPS1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008150,GO:0009888,GO:0009914,GO:0009926,GO:0009987,GO:0010087,GO:0010089,GO:0010487,GO:0010817,GO:0016740,GO:0016765,GO:0016768,GO:0030154,GO:0032502,GO:0044424,GO:0044464,GO:0048759,GO:0048856,GO:0048869,GO:0051179,GO:0051234,GO:0060918,GO:0065007,GO:0065008,GO:1905177	2.1.1.43,2.5.1.79	ko:K11424,ko:K18787	ko00310,ko05202,map00310,map05202	-	R03875,R03938,R04866,R04867	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko01000,ko03036	-	-	-	SET,Spermine_synt_N,Spermine_synth
CMS1_k127_4152068_0	1385935.N836_14100	1.548e-226	725.0	COG0370@1|root,COG0370@2|Bacteria,1G058@1117|Cyanobacteria,1H8CQ@1150|Oscillatoriales	1117|Cyanobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
CMS1_k127_4152068_1	933262.AXAM01000028_gene3304	5.289e-18	86.0	COG1918@1|root,COG1918@2|Bacteria,1N8ZJ@1224|Proteobacteria,43AAA@68525|delta/epsilon subdivisions,2WT3F@28221|Deltaproteobacteria,2MM74@213118|Desulfobacterales	28221|Deltaproteobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
CMS1_k127_4152068_2	1123274.KB899407_gene334	4.753e-09	60.0	COG1918@1|root,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	feoA	-	-	ko:K03711,ko:K04758	-	-	-	-	ko00000,ko02000,ko03000	-	-	-	FUR,FeoA
CMS1_k127_4228937_1	1195236.CTER_2389	1.524e-39	152.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3WG99@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
CMS1_k127_4228937_0	431943.CKL_2166	1.744e-68	235.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,36HYD@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
CMS1_k127_4228937_2	565034.BHWA1_00950	4.103e-31	126.0	COG0781@1|root,COG0781@2|Bacteria,2J91Y@203691|Spirochaetes	203691|Spirochaetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
CMS1_k127_4228937_4	4641.GSMUA_Achr8P11650_001	1.825e-10	74.0	COG0457@1|root,KOG0548@2759|Eukaryota,37KEJ@33090|Viridiplantae,3G8SM@35493|Streptophyta,3KQRS@4447|Liliopsida	35493|Streptophyta	O	Heat shock protein STI	-	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009611,GO:0009628,GO:0009987,GO:0010033,GO:0016043,GO:0022607,GO:0031072,GO:0033554,GO:0034605,GO:0034622,GO:0035966,GO:0042221,GO:0043933,GO:0044085,GO:0050896,GO:0051131,GO:0051716,GO:0051879,GO:0065003,GO:0070417,GO:0070678,GO:0071840	-	ko:K09553	ko05020,map05020	-	-	-	ko00000,ko00001,ko03110	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
CMS1_k127_4228937_3	545695.TREAZ_1637	6.592e-20	105.0	COG0457@1|root,COG0457@2|Bacteria,2J58Z@203691|Spirochaetes	203691|Spirochaetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8
CMS1_k127_4229164_1	573413.Spirs_4306	4.999e-260	815.0	COG0187@1|root,COG0187@2|Bacteria,2J67M@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
CMS1_k127_4229164_0	246194.CHY_2704	3.822e-282	889.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,42FIB@68295|Thermoanaerobacterales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
CMS1_k127_423117_1	1317122.ATO12_08370	1.867e-82	281.0	COG3203@1|root,COG3203@2|Bacteria,4NDYW@976|Bacteroidetes,1HWYP@117743|Flavobacteriia,2YHEN@290174|Aquimarina	976|Bacteroidetes	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
CMS1_k127_423117_2	867902.Ornrh_2101	3.113e-75	257.0	COG3005@1|root,COG3005@2|Bacteria,4NK7R@976|Bacteroidetes,1I21Z@117743|Flavobacteriia	976|Bacteroidetes	C	cytochrome c nitrate reductase, small subunit	nrfH	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
CMS1_k127_423117_0	869213.JCM21142_137	2.217e-157	500.0	COG3303@1|root,COG3303@2|Bacteria,4NG0P@976|Bacteroidetes,47JAN@768503|Cytophagia	976|Bacteroidetes	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	nrfA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
CMS1_k127_4270667_0	991.IW20_02970	3.994e-18	92.0	COG3568@1|root,COG3568@2|Bacteria,4P50U@976|Bacteroidetes,1I9J1@117743|Flavobacteriia,2NYGN@237|Flavobacterium	976|Bacteroidetes	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4270667_2	1150600.ADIARSV_2338	9.713e-15	76.0	COG1361@1|root,COG1361@2|Bacteria,4NT9E@976|Bacteroidetes	976|Bacteroidetes	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
CMS1_k127_4270667_1	1385935.N836_29130	1.326e-16	93.0	COG3613@1|root,COG3613@2|Bacteria,1GEY4@1117|Cyanobacteria	1117|Cyanobacteria	F	nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4290229_1	563192.HMPREF0179_02963	5.99e-23	115.0	COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria	2|Bacteria	O	tape measure	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	PhageMin_Tail,Tape_meas_lam_C
CMS1_k127_4290229_3	1207063.P24_13800	1.09e-05	56.0	2C5GI@1|root,2Z8C1@2|Bacteria,1R8XM@1224|Proteobacteria,2TUME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	P22 coat protein - gene protein 5	-	-	-	-	-	-	-	-	-	-	-	-	P22_CoatProtein
CMS1_k127_4290229_2	1150626.PHAMO_80073	1.692e-14	86.0	2BF3Y@1|root,315AZ@2|Bacteria,1NCT0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4055
CMS1_k127_4290229_0	1123405.AUMM01000017_gene2712	2.609e-90	313.0	COG1783@1|root,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,4HDMY@91061|Bacilli	91061|Bacilli	L	Phage terminase, large subunit	yqaT	-	-	ko:K06909	-	-	-	-	ko00000	-	-	-	Terminase_3,Terminase_3C
CMS1_k127_43274_1	204536.SULAZ_1643	1.892e-11	72.0	COG1579@1|root,COG1579@2|Bacteria,2G5B1@200783|Aquificae	200783|Aquificae	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
CMS1_k127_43274_0	445987.BVAVS116_0253	8.196e-45	178.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
CMS1_k127_4432033_8	1296415.JACC01000007_gene2449	8.905e-06	61.0	COG1747@1|root,COG1747@2|Bacteria,4NEB8@976|Bacteroidetes,1HXVQ@117743|Flavobacteriia,2YI6Y@290174|Aquimarina	976|Bacteroidetes	S	Motility related/secretion protein	sprA	-	-	-	-	-	-	-	-	-	-	-	SprA_N
CMS1_k127_4432033_6	269797.Mbar_A0367	6.432e-19	99.0	COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,2N951@224756|Methanomicrobia	224756|Methanomicrobia	S	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
CMS1_k127_4432033_0	1034769.KB910518_gene207	9.852e-233	770.0	COG0366@1|root,COG3291@1|root,COG5434@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria,COG5434@2|Bacteria,1V0U1@1239|Firmicutes,4HV3E@91061|Bacilli,26RZU@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-amylase	aml1	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CBM53,CBM_35,CHB_HEX_C_1
CMS1_k127_4432033_7	1536772.R70723_17420	4.363e-12	81.0	COG0366@1|root,COG1501@1|root,COG5434@1|root,COG0366@2|Bacteria,COG1501@2|Bacteria,COG5434@2|Bacteria,1V0U1@1239|Firmicutes,4HV3E@91061|Bacilli,26RZU@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-amylase	aml1	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CBM53,CBM_35,CHB_HEX_C_1
CMS1_k127_4432033_1	926561.KB900617_gene1911	4.896e-120	428.0	COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria	2|Bacteria	G	belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	AMPK1_CBM,Alpha-amylase,Big_5,CBM_48,CHB_HEX_C_1,DUF3372,PUD
CMS1_k127_4432033_4	945713.IALB_1525	6.329e-43	168.0	COG1947@1|root,COG1947@2|Bacteria	2|Bacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.1.1.182,2.7.1.148	ko:K00919,ko:K02528,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096,M00582	R05634,R10716	RC00002,RC00003,RC01439,RC03257	ko00000,ko00001,ko00002,ko01000,ko02000,ko03009	3.A.1.29	-	iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460	GHMP_kinases_C,GHMP_kinases_N
CMS1_k127_4432033_3	638301.HMPREF0444_1256	5.101e-70	244.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,4H9V5@91061|Bacilli,27F9R@186828|Carnobacteriaceae	91061|Bacilli	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000270,GO:0000271,GO:0003674,GO:0003824,GO:0003977,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0030203,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
CMS1_k127_4432033_2	498761.HM1_0727	2.464e-118	387.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
CMS1_k127_4432033_5	665571.STHERM_c10400	7.225e-39	152.0	COG1825@1|root,COG1825@2|Bacteria,2J75H@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
CMS1_k127_4444376_0	1128398.Curi_c26070	2.609e-143	465.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,2681S@186813|unclassified Clostridiales	186801|Clostridia	L	Putative RNA methylase family UPF0020	ypsC	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
CMS1_k127_4453866_2	1408303.JNJJ01000108_gene70	2.44e-35	141.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HEC8@91061|Bacilli,1ZDXR@1386|Bacillus	91061|Bacilli	M	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
CMS1_k127_4453866_1	1094508.Tsac_1740	3.157e-49	180.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,42G2R@68295|Thermoanaerobacterales	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS1_k127_4453866_0	926561.KB900617_gene1536	4.82e-156	506.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,3WA6B@53433|Halanaerobiales	186801|Clostridia	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
CMS1_k127_4476146_2	867900.Celly_2001	0.0003987	44.0	298QN@1|root,2ZVV0@2|Bacteria,4NNRX@976|Bacteroidetes,1I2A6@117743|Flavobacteriia,1F9BG@104264|Cellulophaga	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4476146_1	1280689.AUJC01000001_gene2126	2.04e-108	370.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,36DF6@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
CMS1_k127_4476146_0	1499967.BAYZ01000117_gene3327	4.8e-127	419.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM-2	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
CMS1_k127_4478615_6	1121930.AQXG01000001_gene1046	2.355e-17	84.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
CMS1_k127_4478615_2	1236542.BALM01000008_gene2896	4.361e-113	372.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,2Q9HD@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM band 7 protein	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
CMS1_k127_4478615_1	1515746.HR45_14195	3.094e-114	376.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,2Q8IF@267890|Shewanellaceae	1236|Gammaproteobacteria	O	PFAM band 7 protein	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
CMS1_k127_4478615_7	1168289.AJKI01000002_gene2352	8.607e-11	73.0	COG4915@1|root,COG4915@2|Bacteria	2|Bacteria	S	5-bromo-4-chloroindolyl phosphate hydrolysis protein	xpaC	-	-	-	-	-	-	-	-	-	-	-	Halogen_Hydrol
CMS1_k127_4478615_3	1042376.AFPK01000026_gene2194	1.181e-46	174.0	COG0705@1|root,COG0705@2|Bacteria,4NGT3@976|Bacteroidetes,1HXF0@117743|Flavobacteriia,406HS@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS1_k127_4478615_9	1121456.ATVA01000017_gene211	1.843e-08	67.0	COG1652@1|root,COG1652@2|Bacteria,1N2HY@1224|Proteobacteria,42URJ@68525|delta/epsilon subdivisions,2WQ66@28221|Deltaproteobacteria,2MC9F@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398,LysM
CMS1_k127_4478615_0	926561.KB900618_gene337	7.661e-132	430.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia	186801|Clostridia	E	PFAM aminotransferase class I and II	yugH	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_4478615_8	237368.SCABRO_01615	2.431e-10	68.0	COG3688@1|root,COG3688@2|Bacteria	2|Bacteria	D	RNA-binding protein containing a PIN domain	yacP	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_IV,GTP_EFTU,NYN_YacP
CMS1_k127_4478615_5	1173028.ANKO01000189_gene402	6.328e-30	132.0	COG0627@1|root,COG0627@2|Bacteria,1GBQK@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
CMS1_k127_4478615_4	1347087.CBYO010000014_gene2268	2.331e-37	145.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,4HB1W@91061|Bacilli	91061|Bacilli	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
CMS1_k127_4493431_1	1122605.KB893643_gene537	2.352e-12	79.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Thioredoxin_4,VKOR
CMS1_k127_4493431_0	926561.KB900618_gene291	1.01e-160	517.0	COG0366@1|root,COG0366@2|Bacteria,1U7JS@1239|Firmicutes,24ATB@186801|Clostridia,3WBDA@53433|Halanaerobiales	186801|Clostridia	G	Glycogen debranching enzyme, glucanotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
CMS1_k127_4534199_2	489825.LYNGBM3L_42570	3.384e-85	319.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1H9WN@1150|Oscillatoriales	1117|Cyanobacteria	T	7TM diverse intracellular signalling	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1
CMS1_k127_4534199_3	518766.Rmar_2227	2.753e-58	211.0	COG2197@1|root,COG2197@2|Bacteria,4NP2G@976|Bacteroidetes,1FIR1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
CMS1_k127_4534199_4	1265505.ATUG01000001_gene4601	1.596e-17	92.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
CMS1_k127_4534199_0	926692.AZYG01000072_gene2731	2.605e-203	644.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia	186801|Clostridia	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
CMS1_k127_4534199_1	889378.Spiaf_0775	5.472e-90	312.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
CMS1_k127_4558761_0	382464.ABSI01000006_gene890	7.15e-12	78.0	COG0457@1|root,COG0457@2|Bacteria,46W4N@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4574677_1	945713.IALB_0555	2.206e-123	399.0	COG1459@1|root,COG1459@2|Bacteria	2|Bacteria	U	protein transport across the cell outer membrane	pilC2	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
CMS1_k127_4574677_0	945713.IALB_0552	8.55e-147	486.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K13687	-	-	-	-	ko00000,ko01000,ko01003	-	GT89	-	DUF2723,PMT_2
CMS1_k127_4574677_2	5786.XP_003287008.1	0.0001152	54.0	KOG1125@1|root,KOG1125@2759|Eukaryota,3X9HM@554915|Amoebozoa	554915|Amoebozoa	U	TPR repeat	-	GO:0000268,GO:0003674,GO:0005048,GO:0005052,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006605,GO:0006625,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0009987,GO:0015031,GO:0015833,GO:0015919,GO:0016020,GO:0016043,GO:0016558,GO:0016560,GO:0017038,GO:0031090,GO:0031903,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042579,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043574,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0044743,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:0098588,GO:0098805	-	ko:K13342	ko04146,map04146	-	-	-	ko00000,ko00001,ko04131	3.A.20.1	-	-	TPR_11
CMS1_k127_4576327_0	439235.Dalk_0572	1.132e-116	409.0	COG0745@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MI2B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
CMS1_k127_4576327_1	744872.Spica_0812	2.133e-32	138.0	COG5608@1|root,COG5608@2|Bacteria,2J9FY@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late embryogenesis abundant protein	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
CMS1_k127_4592264_0	1296416.JACB01000017_gene5138	5.186e-38	152.0	2A5H9@1|root,30U7G@2|Bacteria,4NPEP@976|Bacteroidetes,1I45P@117743|Flavobacteriia,2YIRD@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_460968_2	858215.Thexy_0020	1.969e-33	132.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
CMS1_k127_460968_3	926561.KB900621_gene2777	1.617e-06	57.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	ko:K01999,ko:K08309	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko01000,ko01011,ko02000	3.A.1.4	GH23	-	Beta-lactamase,OmpA,PD40,SLT,TPR_16,TPR_6,TPR_8,Thioredoxin_7
CMS1_k127_460968_1	684719.HIMB114_00005110	1.487e-50	191.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,4BPBR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS1_k127_460968_0	1045858.Bint_0472	2.298e-91	317.0	COG0342@1|root,COG0342@2|Bacteria,2J5UV@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
CMS1_k127_4612498_5	431943.CKL_0153	0.0008382	51.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,36G5K@31979|Clostridiaceae	186801|Clostridia	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
CMS1_k127_4612498_0	318464.IO99_09155	2.54e-261	844.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,36F91@31979|Clostridiaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
CMS1_k127_4612498_2	1123274.KB899437_gene679	1.952e-12	71.0	COG3500@1|root,COG3500@2|Bacteria,2J9W3@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
CMS1_k127_4612498_3	99598.Cal7507_3206	7.885e-11	66.0	COG3500@1|root,COG3500@2|Bacteria,1G4DS@1117|Cyanobacteria,1HMCU@1161|Nostocales	1117|Cyanobacteria	S	PFAM Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
CMS1_k127_4612498_1	511051.CSE_05000	7.197e-80	274.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0295	TAL_FSA
CMS1_k127_4612498_4	1121373.KB903624_gene2412	0.0006581	50.0	2DT69@1|root,33IW5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4616483_2	1541065.JRFE01000006_gene4725	8.56e-14	73.0	COG0366@1|root,COG0366@2|Bacteria,1G0QI@1117|Cyanobacteria,3VMAT@52604|Pleurocapsales	1117|Cyanobacteria	G	Alpha amylase, catalytic domain	-	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_4616483_1	1265505.ATUG01000001_gene3452	7.674e-41	161.0	COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WQQK@28221|Deltaproteobacteria,2MPXV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS1_k127_4616483_0	944547.ABLL_1602	4.803e-57	213.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42QQC@68525|delta/epsilon subdivisions,2YPD6@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	SMART GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS1_k127_4617151_0	316274.Haur_1779	8.278e-58	220.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	Dam,PhageMin_Tail
CMS1_k127_4619213_1	1408433.JHXV01000019_gene1919	6.181e-70	248.0	COG0181@1|root,COG0181@2|Bacteria,4NHH4@976|Bacteroidetes,1HXKZ@117743|Flavobacteriia,2PB12@246874|Cryomorphaceae	976|Bacteroidetes	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Porphobil_deam,Porphobil_deamC
CMS1_k127_4619213_2	1123274.KB899437_gene679	2.599e-67	242.0	COG3500@1|root,COG3500@2|Bacteria,2J9W3@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
CMS1_k127_4619213_5	28072.Nos7524_1268	4.419e-23	106.0	COG3501@1|root,COG3501@2|Bacteria,1G6H3@1117|Cyanobacteria,1HMJM@1161|Nostocales	1117|Cyanobacteria	S	PFAM Phage-related baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4619213_6	63737.Npun_F1410	1.276e-21	102.0	COG3501@1|root,COG3501@2|Bacteria,1G6H3@1117|Cyanobacteria,1HMJM@1161|Nostocales	1117|Cyanobacteria	S	PFAM Phage-related baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4619213_0	349521.HCH_03533	3.51e-277	909.0	COG3209@1|root,COG4104@1|root,COG3209@2|Bacteria,COG4104@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS1_k127_4619213_7	889204.HMPREF9423_0681	3.857e-15	81.0	2FGPQ@1|root,348J9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4619213_4	1347368.HG964407_gene6803	1.946e-27	122.0	COG3878@1|root,COG3878@2|Bacteria,1V0V3@1239|Firmicutes,4HMIQ@91061|Bacilli,1ZH2V@1386|Bacillus	91061|Bacilli	S	Domain of unknown function (DUF1963)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1963
CMS1_k127_4619213_8	580327.Tthe_0316	0.000368	49.0	COG3267@1|root,COG3267@2|Bacteria,1TRGM@1239|Firmicutes,24EPV@186801|Clostridia,42JDI@68295|Thermoanaerobacterales	186801|Clostridia	U	AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
CMS1_k127_4619213_3	1122226.AUHX01000008_gene1531	3.025e-62	222.0	COG0428@1|root,COG0428@2|Bacteria,4NMCZ@976|Bacteroidetes,1I1Q1@117743|Flavobacteriia	976|Bacteroidetes	P	transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
CMS1_k127_4620657_0	394503.Ccel_0178	9.835e-85	293.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,36DCE@31979|Clostridiaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
CMS1_k127_4620657_1	572547.Amico_1475	3.153e-56	211.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,3T9T4@508458|Synergistetes	508458|Synergistetes	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
CMS1_k127_4620657_2	5911.EAR82286	5.267e-08	64.0	COG3914@1|root,KOG4308@1|root,KOG4308@2759|Eukaryota,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
CMS1_k127_4626118_5	1123274.KB899437_gene680	1.468e-59	207.0	COG1652@1|root,COG1652@2|Bacteria,2J6VQ@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
CMS1_k127_4626118_3	1123274.KB899437_gene681	2.836e-70	240.0	2AMSQ@1|root,31CP6@2|Bacteria,2J89Y@203691|Spirochaetes	203691|Spirochaetes	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
CMS1_k127_4626118_2	1123274.KB899437_gene682	6.067e-137	455.0	COG3497@1|root,COG3497@2|Bacteria,2J79J@203691|Spirochaetes	203691|Spirochaetes	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
CMS1_k127_4626118_4	1123274.KB899437_gene690	1.039e-68	235.0	2BR5E@1|root,32K3G@2|Bacteria,2J881@203691|Spirochaetes	203691|Spirochaetes	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
CMS1_k127_4626118_1	1123274.KB899437_gene691	7.566e-219	683.0	COG3497@1|root,COG3497@2|Bacteria,2J6Q0@203691|Spirochaetes	203691|Spirochaetes	S	Phage tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
CMS1_k127_4626118_0	1123274.KB899437_gene693	1.689e-231	739.0	COG3299@1|root,COG3299@2|Bacteria,2J6Y3@203691|Spirochaetes	203691|Spirochaetes	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
CMS1_k127_4642880_1	289376.THEYE_A1052	1.236e-76	270.0	COG1408@1|root,COG1408@2|Bacteria,3J0SB@40117|Nitrospirae	40117|Nitrospirae	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
CMS1_k127_4642880_3	1033810.HLPCO_001753	3.398e-60	216.0	COG1091@1|root,COG1091@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose reductase activity	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
CMS1_k127_4642880_2	1304885.AUEY01000025_gene2740	6.911e-67	234.0	COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,1PMC1@1224|Proteobacteria,430UF@68525|delta/epsilon subdivisions,2WVWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
CMS1_k127_4642880_5	716544.wcw_0905	4.507e-12	72.0	COG0727@1|root,COG0727@2|Bacteria,2JG8E@204428|Chlamydiae	204428|Chlamydiae	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS1_k127_4642880_0	439235.Dalk_1076	1.89e-79	272.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42QIX@68525|delta/epsilon subdivisions,2WJHE@28221|Deltaproteobacteria,2MIMI@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS1_k127_4642880_4	223926.28807164	5.676e-22	98.0	COG0727@1|root,32S46@2|Bacteria,1MZCU@1224|Proteobacteria,1SCG7@1236|Gammaproteobacteria,1XYHX@135623|Vibrionales	135623|Vibrionales	S	Fe-S-cluster oxidoreductase	yeiW	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS1_k127_4670614_1	204669.Acid345_2620	5.562e-118	395.0	COG0773@1|root,COG0773@2|Bacteria,3Y2M2@57723|Acidobacteria,2JIE2@204432|Acidobacteriia	204432|Acidobacteriia	M	Mur ligase middle domain	-	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
CMS1_k127_4670614_3	7668.SPU_007752-tr	1.159e-12	79.0	COG0666@1|root,KOG0504@2759|Eukaryota,38C53@33154|Opisthokonta	33154|Opisthokonta	P	phosphoric diester hydrolase activity	PHO81	GO:0001932,GO:0001933,GO:0003674,GO:0004857,GO:0004860,GO:0004861,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006469,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0012505,GO:0016020,GO:0016538,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0030234,GO:0030291,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0042325,GO:0042326,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043549,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045936,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071900,GO:0071901,GO:0071944,GO:0080090,GO:0098772	-	ko:K06653,ko:K15503	ko04111,map04111	-	-	-	ko00000,ko00001,ko01009,ko03400	-	-	-	Ank_2,Ank_4,GDPD,SPX
CMS1_k127_4670614_2	926549.KI421517_gene2173	5.619e-61	217.0	COG1451@1|root,COG1451@2|Bacteria,4NNY6@976|Bacteroidetes,47QZY@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
CMS1_k127_4670614_0	1304284.L21TH_2220	6.008e-171	544.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,36EEA@31979|Clostridiaceae	186801|Clostridia	E	Cleaves the N-terminal amino acid of tripeptides	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
CMS1_k127_4671194_3	926561.KB900617_gene1358	4.07e-25	123.0	COG0366@1|root,COG1974@1|root,COG0366@2|Bacteria,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,HTH_3,PKD,Peptidase_S24,SLH
CMS1_k127_4671194_4	645991.Sgly_2993	4.825e-18	100.0	COG2247@1|root,COG4733@1|root,COG2247@2|Bacteria,COG4733@2|Bacteria,1UZS5@1239|Firmicutes,24FE6@186801|Clostridia,2600Z@186807|Peptococcaceae	186801|Clostridia	M	cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Endopep_inhib,fn3
CMS1_k127_4671194_2	760192.Halhy_2718	1.242e-63	249.0	COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,1ITAS@117747|Sphingobacteriia	976|Bacteroidetes	O	Serine protease, subtilase family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
CMS1_k127_4671194_1	28229.ND2E_0940	4.457e-83	281.0	COG0670@1|root,COG0670@2|Bacteria,1MVGU@1224|Proteobacteria,1RNKB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
CMS1_k127_4671194_6	665571.STHERM_c06620	3.629e-11	72.0	COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
CMS1_k127_4671194_5	1220534.B655_0707	3.073e-14	83.0	arCOG12322@1|root,arCOG12322@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4671194_0	1041930.Mtc_0623	1.124e-107	361.0	COG0438@1|root,arCOG01410@2157|Archaea	2157|Archaea	M	Glycosyltransferase	-	-	-	ko:K16703	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
CMS1_k127_4678695_0	1353529.M899_0650	8.152e-185	606.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions	1224|Proteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
CMS1_k127_4678770_4	349161.Dred_2192	2.753e-10	61.0	COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia,2640S@186807|Peptococcaceae	186801|Clostridia	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
CMS1_k127_4678770_1	1123288.SOV_1c06360	4.248e-29	119.0	COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,4H31A@909932|Negativicutes	909932|Negativicutes	C	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
CMS1_k127_4678770_5	639282.DEFDS_1143	2.157e-07	54.0	COG0685@1|root,COG0685@2|Bacteria,2GF5C@200930|Deferribacteres	200930|Deferribacteres	C	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
CMS1_k127_4678770_0	880072.Desac_0014	2.045e-136	450.0	COG1219@1|root,COG1219@2|Bacteria,1MWIZ@1224|Proteobacteria,42N1Z@68525|delta/epsilon subdivisions,2WJUS@28221|Deltaproteobacteria,2MR6M@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the ClpX chaperone family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
CMS1_k127_4678770_3	639030.JHVA01000001_gene652	2.607e-23	104.0	COG2050@1|root,COG2050@2|Bacteria,3Y57I@57723|Acidobacteria,2JJU4@204432|Acidobacteriia	204432|Acidobacteriia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
CMS1_k127_4678770_6	1227352.C173_00360	0.0001081	48.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,26RJM@186822|Paenibacillaceae	91061|Bacilli	NU	type II secretion system protein	pilB	-	-	ko:K02243,ko:K02652	-	M00429	-	-	ko00000,ko00002,ko02035,ko02044	3.A.14.1,3.A.15.2	-	-	T2SSE,T2SSE_N
CMS1_k127_4678770_2	945713.IALB_1840	6.018e-27	117.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Cytochrome_C554,DUF11,SLH
CMS1_k127_4685659_0	573413.Spirs_3787	2.353e-12	69.0	COG2114@1|root,COG2114@2|Bacteria,2J9VX@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4694593_6	445971.ANASTE_01954	2.684e-38	153.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,25VVD@186806|Eubacteriaceae	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
CMS1_k127_4694593_2	411468.CLOSCI_01986	2.541e-170	552.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,21XK2@1506553|Lachnoclostridium	186801|Clostridia	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	pgcA	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
CMS1_k127_4694593_7	189425.PGRAT_26210	3.921e-27	121.0	COG3568@1|root,COG3568@2|Bacteria,1VJAZ@1239|Firmicutes,4I6R0@91061|Bacilli,26UDK@186822|Paenibacillaceae	91061|Bacilli	S	Carbohydrate/starch-binding module (family 21)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_21
CMS1_k127_4694593_0	926561.KB900617_gene1905	7.848e-210	691.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,Big_2,CBM_20,CBM_48,PUD
CMS1_k127_4694593_5	573413.Spirs_0490	1.431e-43	166.0	2C7TX@1|root,33VWG@2|Bacteria,2J836@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4694593_8	436114.SYO3AOP1_0254	1.107e-25	111.0	COG0319@1|root,COG0319@2|Bacteria,2G5AR@200783|Aquificae	200783|Aquificae	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
CMS1_k127_4694593_3	574087.Acear_0618	1.117e-94	338.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia,3WA9K@53433|Halanaerobiales	186801|Clostridia	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
CMS1_k127_4694593_4	289377.HL41_04600	5.913e-93	315.0	COG1702@1|root,COG1702@2|Bacteria,2GGQM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
CMS1_k127_4694593_1	760142.Hipma_0431	8.289e-202	645.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2M6JA@213113|Desulfurellales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
CMS1_k127_4694593_9	1196322.A370_04646	7.2e-17	84.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,36ES8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
CMS1_k127_4703219_0	334413.FMG_0652	1.248e-95	336.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,22G1I@1570339|Peptoniphilaceae	186801|Clostridia	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
CMS1_k127_4703219_1	858215.Thexy_0194	1.724e-18	91.0	COG1633@1|root,COG1633@2|Bacteria,1VGHR@1239|Firmicutes,24QXX@186801|Clostridia,42HHW@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS1_k127_472020_0	317025.Tcr_2183	1.637e-28	115.0	COG3655@1|root,COG3655@2|Bacteria,1N6VH@1224|Proteobacteria,1SDAJ@1236|Gammaproteobacteria,4617S@72273|Thiotrichales	72273|Thiotrichales	K	Cro/C1-type HTH DNA-binding domain	-	-	-	ko:K07727	-	-	-	-	ko00000,ko03000	-	-	-	HTH_26
CMS1_k127_472020_1	298386.PBPRB1381	1.379e-20	98.0	2DT7B@1|root,33J0R@2|Bacteria,1NKDX@1224|Proteobacteria,1SGB3@1236|Gammaproteobacteria,1XX4N@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF2975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2975
CMS1_k127_472049_1	1123274.KB899410_gene3492	4.338e-115	402.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
CMS1_k127_472049_0	509191.AEDB02000076_gene1466	9.914e-161	518.0	COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,247UD@186801|Clostridia,3WHFC@541000|Ruminococcaceae	186801|Clostridia	L	DNA modification repair radical SAM protein	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
CMS1_k127_472049_3	373903.Hore_05000	4.504e-52	193.0	COG1573@1|root,COG1573@2|Bacteria,1UY78@1239|Firmicutes,24FDP@186801|Clostridia,3WBSD@53433|Halanaerobiales	186801|Clostridia	L	Domain of unknown function (DUF4130	-	-	-	-	-	-	-	-	-	-	-	-	DUF4130
CMS1_k127_472049_2	161156.JQKW01000008_gene462	1.819e-60	215.0	COG1059@1|root,COG1059@2|Bacteria	2|Bacteria	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
CMS1_k127_472049_4	58344.JOEL01000044_gene886	2.314e-05	47.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
CMS1_k127_4723559_1	1499967.BAYZ01000104_gene3710	3.663e-42	167.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	rnaZ	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
CMS1_k127_4723559_2	1433126.BN938_0267	3.119e-23	112.0	COG5026@1|root,COG5026@2|Bacteria,4NIN0@976|Bacteroidetes,2FQ47@200643|Bacteroidia	976|Bacteroidetes	G	Hexokinase	-	-	2.7.1.1	ko:K00844	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04910,ko04930,ko04973,ko05230,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200,map04066,map04910,map04930,map04973,map05230	M00001,M00549	R00299,R00760,R00867,R01326,R01600,R01786,R01961,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	Hexokinase_1,Hexokinase_2
CMS1_k127_4723559_0	56780.SYN_00619	1.237e-68	243.0	COG0613@1|root,COG0613@2|Bacteria,1QV9S@1224|Proteobacteria,43BP1@68525|delta/epsilon subdivisions,2X70C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SMART phosphoesterase PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
CMS1_k127_4723819_0	1267535.KB906767_gene3177	1.706e-200	632.0	COG1158@1|root,COG1158@2|Bacteria,3Y2V3@57723|Acidobacteria,2JHRC@204432|Acidobacteriia	204432|Acidobacteriia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
CMS1_k127_4723819_1	1125700.HMPREF9195_02096	7.29e-24	102.0	COG0254@1|root,COG0254@2|Bacteria,2J93Z@203691|Spirochaetes	203691|Spirochaetes	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
CMS1_k127_4755032_2	1291050.JAGE01000002_gene3562	1.258e-50	187.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_4755032_1	1291050.JAGE01000002_gene3561	6.634e-84	284.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
CMS1_k127_4755032_0	1443665.JACA01000013_gene4100	1.673e-220	723.0	COG2898@1|root,COG3321@1|root,COG2898@2|Bacteria,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,1HYG4@117743|Flavobacteriia,2YHN1@290174|Aquimarina	976|Bacteroidetes	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Beta_elim_lyase,DUF2156,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS1_k127_4771747_0	880073.Calab_1632	3.255e-33	134.0	COG2109@1|root,COG2109@2|Bacteria,2NPNR@2323|unclassified Bacteria	2|Bacteria	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
CMS1_k127_4771747_2	1379698.RBG1_1C00001G0972	2.172e-05	53.0	COG0138@1|root,COG0138@2|Bacteria,2NNQ2@2323|unclassified Bacteria	2|Bacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
CMS1_k127_4771747_1	392500.Swoo_4356	3.322e-18	93.0	COG3040@1|root,COG3040@2|Bacteria,1PX5K@1224|Proteobacteria,1T8RX@1236|Gammaproteobacteria,2QE8T@267890|Shewanellaceae	1236|Gammaproteobacteria	M	lipid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4774089_3	1121456.ATVA01000012_gene2949	3.13e-32	135.0	COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,42TWK@68525|delta/epsilon subdivisions,2WQSK@28221|Deltaproteobacteria,2MCZ7@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferase WecB/TagA/CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
CMS1_k127_4774089_0	380749.HY04AAS1_1611	4.484e-135	437.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
CMS1_k127_4774089_2	47839.CCAU010000017_gene3580	9.685e-36	141.0	COG5017@1|root,COG5017@2|Bacteria,2IGA4@201174|Actinobacteria,239IF@1762|Mycobacteriaceae	201174|Actinobacteria	S	Glycosyltransferase family 28 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
CMS1_k127_4774089_1	487521.OCU_10150	1.073e-43	166.0	COG0707@1|root,COG0707@2|Bacteria,2IKNK@201174|Actinobacteria,23BQV@1762|Mycobacteriaceae	201174|Actinobacteria	M	Oligosaccharide biosynthesis protein Alg14 like	-	-	-	-	-	-	-	-	-	-	-	-	Alg14,Glyco_tran_28_C
CMS1_k127_479091_2	443143.GM18_0291	1.446e-58	208.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42UDS@68525|delta/epsilon subdivisions,2WPGE@28221|Deltaproteobacteria,43SVS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
CMS1_k127_479091_1	1121405.dsmv_0190	1.063e-61	220.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,2MJG9@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
CMS1_k127_479091_0	521045.Kole_1174	1.177e-154	504.0	COG0366@1|root,COG0366@2|Bacteria,2GCN1@200918|Thermotogae	200918|Thermotogae	G	SMART alpha amylase catalytic sub domain	-	-	3.2.1.1,3.2.1.20,5.4.99.16	ko:K01187,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,Malt_amylase_C
CMS1_k127_4803412_0	907348.TresaDRAFT_1929	1.083e-49	196.0	COG0366@1|root,COG0366@2|Bacteria,2J9X3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_4806896_2	906968.Trebr_1140	2.705e-66	239.0	COG1377@1|root,COG1377@2|Bacteria,2J5EU@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
CMS1_k127_4806896_5	1289135.A966_10387	3.492e-49	184.0	COG1684@1|root,COG1684@2|Bacteria,2J6DD@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
CMS1_k127_4806896_6	401526.TcarDRAFT_2123	1.015e-21	96.0	COG1987@1|root,COG1987@2|Bacteria,1VEHF@1239|Firmicutes,4H54Q@909932|Negativicutes	909932|Negativicutes	N	Flagellar biosynthetic protein FliQ	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
CMS1_k127_4806896_0	1449126.JQKL01000001_gene1342	2.632e-86	292.0	COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia,268V4@186813|unclassified Clostridiales	186801|Clostridia	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
CMS1_k127_4806896_11	1122919.KB905548_gene2213	0.0002384	51.0	COG3190@1|root,COG3190@2|Bacteria,1VGFI@1239|Firmicutes,4HJJQ@91061|Bacilli,2759H@186822|Paenibacillaceae	91061|Bacilli	N	Flagellar biosynthesis protein, FliO	fliZ	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
CMS1_k127_4806896_4	573413.Spirs_1576	4.763e-59	218.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,2J5P8@203691|Spirochaetes	203691|Spirochaetes	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
CMS1_k127_4806896_8	264462.Bd3329	1.511e-07	60.0	COG1580@1|root,COG1580@2|Bacteria,1NBUX@1224|Proteobacteria,42RSV@68525|delta/epsilon subdivisions,2MTD5@213481|Bdellovibrionales,2WR7K@28221|Deltaproteobacteria	213481|Bdellovibrionales	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
CMS1_k127_4806896_3	1480694.DC28_02380	6.683e-63	224.0	COG1360@1|root,COG1360@2|Bacteria,2J68Q@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
CMS1_k127_4806896_1	889378.Spiaf_2095	1.601e-79	273.0	COG1291@1|root,COG1291@2|Bacteria,2J5HT@203691|Spirochaetes	203691|Spirochaetes	N	MotA TolQ ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
CMS1_k127_4806896_7	1150474.JQJI01000001_gene1846	2.822e-14	74.0	COG1582@1|root,COG1582@2|Bacteria,2GDIZ@200918|Thermotogae	200918|Thermotogae	N	flagellar	-	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
CMS1_k127_4806896_9	1121374.KB891586_gene2845	1.247e-05	56.0	COG2604@1|root,COG2604@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
CMS1_k127_4806896_12	313612.L8106_01597	0.000807	51.0	COG4254@1|root,COG4254@2|Bacteria,1G662@1117|Cyanobacteria,1HA7R@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS1_k127_4831799_5	913865.DOT_6091	6.995e-25	109.0	arCOG11412@1|root,31S84@2|Bacteria,1V6H1@1239|Firmicutes,24K0T@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4831799_7	1123274.KB899437_gene676	1.279e-09	62.0	2A6AJ@1|root,30V37@2|Bacteria,2J9E5@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF2997)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2997
CMS1_k127_4831799_0	1123274.KB899437_gene677	1.077e-215	680.0	COG0464@1|root,COG0464@2|Bacteria,2J6T3@203691|Spirochaetes	203691|Spirochaetes	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS1_k127_4831799_2	869209.Tresu_2588	4.643e-72	259.0	COG2304@1|root,COG2304@2|Bacteria,2J7HI@203691|Spirochaetes	203691|Spirochaetes	S	Von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
CMS1_k127_4831799_4	869209.Tresu_2587	3.68e-32	129.0	29Y8W@1|root,30K2M@2|Bacteria,2J95N@203691|Spirochaetes	203691|Spirochaetes	S	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4831799_1	1123274.KB899437_gene685	4.291e-159	516.0	2AKYY@1|root,31BSK@2|Bacteria,2J5AZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4831799_3	1123274.KB899437_gene686	8.335e-42	164.0	COG4385@1|root,COG4385@2|Bacteria,2J8HT@203691|Spirochaetes	203691|Spirochaetes	S	Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
CMS1_k127_4831799_6	1321815.HMPREF9193_00521	1.818e-23	103.0	2AMUI@1|root,31CR5@2|Bacteria,2J8IQ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF1257)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1257
CMS1_k127_4831990_2	335541.Swol_0755	1.49e-06	61.0	COG3401@1|root,COG4886@1|root,COG5492@1|root,COG5520@1|root,COG3401@2|Bacteria,COG4886@2|Bacteria,COG5492@2|Bacteria,COG5520@2|Bacteria,1UJJ6@1239|Firmicutes,25F47@186801|Clostridia,42KUB@68298|Syntrophomonadaceae	2|Bacteria	N	S-layer homology domain	-	-	3.2.1.4	ko:K01179,ko:K13730	ko00500,ko01100,ko05100,map00500,map01100,map05100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_2,Big_4,CHB_HEX_C_1,LRR_5,Peptidase_S8,SLH
CMS1_k127_4831990_3	404589.Anae109_3979	1.965e-06	61.0	2C4SZ@1|root,344GS@2|Bacteria,1P2T8@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4831990_1	203119.Cthe_1064	2.239e-87	302.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,3WGVY@541000|Ruminococcaceae	186801|Clostridia	E	aminotransferase class V	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
CMS1_k127_4831990_0	1128398.Curi_c09440	7.107e-90	309.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,267JJ@186813|unclassified Clostridiales	186801|Clostridia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
CMS1_k127_4848946_3	665571.STHERM_c10790	5.941e-41	171.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
CMS1_k127_4848946_7	403833.Pmob_1349	3.175e-19	94.0	COG0350@1|root,COG0350@2|Bacteria,2GDIR@200918|Thermotogae	200918|Thermotogae	H	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
CMS1_k127_4848946_1	1121896.JMLU01000005_gene2455	6.51e-75	262.0	COG0196@1|root,COG0196@2|Bacteria,4NEI9@976|Bacteroidetes,1HXQ5@117743|Flavobacteriia,2NU91@237|Flavobacterium	976|Bacteroidetes	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
CMS1_k127_4848946_0	717231.Flexsi_1981	1.479e-119	402.0	COG0082@1|root,COG0082@2|Bacteria,2GETE@200930|Deferribacteres	200930|Deferribacteres	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
CMS1_k127_4848946_6	272562.CA_C2546	9.521e-26	117.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,36F6A@31979|Clostridiaceae	186801|Clostridia	K	GntR domain protein	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_4848946_5	1125700.HMPREF9195_00103	3.785e-30	133.0	COG3386@1|root,COG3386@2|Bacteria,2J65H@203691|Spirochaetes	203691|Spirochaetes	G	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4848946_8	1173029.JH980292_gene1820	1.73e-06	57.0	COG0457@1|root,COG0457@2|Bacteria,1G36K@1117|Cyanobacteria,1H9PH@1150|Oscillatoriales	1117|Cyanobacteria	O	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_1,TPR_11,TPR_2,TPR_8
CMS1_k127_4848946_2	555079.Toce_0654	1.124e-69	248.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,42FJX@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
CMS1_k127_4848946_4	526224.Bmur_1066	2.372e-39	151.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS1_k127_4849278_2	1123274.KB899437_gene695	1.531e-20	96.0	COG3501@1|root,COG3501@2|Bacteria,2J8CM@203691|Spirochaetes	203691|Spirochaetes	S	Rhs element vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4849278_0	1123274.KB899437_gene695	1.106e-30	129.0	COG3501@1|root,COG3501@2|Bacteria,2J8CM@203691|Spirochaetes	203691|Spirochaetes	S	Rhs element vgr protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4849278_4	700598.Niako_2598	5.139e-13	84.0	COG3501@1|root,COG3501@2|Bacteria,4NFNC@976|Bacteroidetes,1IVWD@117747|Sphingobacteriia	976|Bacteroidetes	S	Phage late control gene D protein (GPD)	-	-	-	ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	Phage_GPD
CMS1_k127_4849278_1	869209.Tresu_2638	1.913e-28	135.0	COG3501@1|root,COG4104@1|root,COG3501@2|Bacteria,COG4104@2|Bacteria,2J85E@203691|Spirochaetes	203691|Spirochaetes	S	SPTR PAAR motif protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4849278_3	869213.JCM21142_41964	1.799e-19	105.0	COG4104@1|root,COG4104@2|Bacteria,4NSCZ@976|Bacteroidetes,47RUU@768503|Cytophagia	976|Bacteroidetes	S	PAAR motif	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
CMS1_k127_4852310_1	1293054.HSACCH_02255	1.884e-21	104.0	COG2199@1|root,COG3706@2|Bacteria,1TSW8@1239|Firmicutes,249J7@186801|Clostridia	186801|Clostridia	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
CMS1_k127_4852310_0	1191523.MROS_0244	1.064e-41	164.0	COG0642@1|root,COG2203@1|root,COG2204@1|root,COG3829@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,HisKA_2,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS1_k127_4856783_2	445335.CBN_1961	8.557e-48	175.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,36JJ0@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
CMS1_k127_4856783_3	1045858.Bint_2625	2.225e-38	161.0	COG2206@1|root,COG2206@2|Bacteria,2JACP@203691|Spirochaetes	203691|Spirochaetes	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
CMS1_k127_4856783_4	215803.DB30_7333	5.648e-11	74.0	COG5616@1|root,COG5616@2|Bacteria,1QW0Q@1224|Proteobacteria,43303@68525|delta/epsilon subdivisions,2WXN6@28221|Deltaproteobacteria,2Z1XR@29|Myxococcales	28221|Deltaproteobacteria	S	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
CMS1_k127_4856783_5	1151117.AJLF01000001_gene1492	2.577e-06	59.0	arCOG02559@1|root,arCOG03264@1|root,arCOG02559@2157|Archaea,arCOG03264@2157|Archaea,2XYKK@28890|Euryarchaeota,24394@183968|Thermococci	183968|Thermococci	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,PEGA
CMS1_k127_4856783_1	1449126.JQKL01000008_gene230	2.21e-57	205.0	COG0778@1|root,COG0778@2|Bacteria,1V0Y6@1239|Firmicutes,24HMV@186801|Clostridia,269WT@186813|unclassified Clostridiales	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS1_k127_4856783_0	1349822.NSB1T_07410	2.086e-76	261.0	COG1592@1|root,COG1592@2|Bacteria,4NH0J@976|Bacteroidetes,2FNC9@200643|Bacteroidia,22WSM@171551|Porphyromonadaceae	976|Bacteroidetes	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050896	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
CMS1_k127_4861379_4	1321778.HMPREF1982_02563	4.024e-07	52.0	COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,26AD0@186813|unclassified Clostridiales	186801|Clostridia	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
CMS1_k127_4861379_0	642492.Clole_1964	2.127e-56	199.0	COG0251@1|root,COG0251@2|Bacteria,1V76U@1239|Firmicutes,24JB7@186801|Clostridia	186801|Clostridia	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
CMS1_k127_4861379_3	717772.THIAE_02625	1.34e-09	60.0	COG3514@1|root,COG3514@2|Bacteria,1NAV1@1224|Proteobacteria,1SC0H@1236|Gammaproteobacteria,4616Q@72273|Thiotrichales	72273|Thiotrichales	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin
CMS1_k127_4861379_1	656519.Halsa_1015	1.991e-55	203.0	COG0726@1|root,COG0726@2|Bacteria,1UW3T@1239|Firmicutes,25KQA@186801|Clostridia,3WBUC@53433|Halanaerobiales	186801|Clostridia	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
CMS1_k127_4861379_6	595536.ADVE02000003_gene4038	0.0002932	45.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2U4RY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	TIGRFAM RHS repeat-associated core domain-containing protein, YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN,VCBS
CMS1_k127_4861379_2	1278078.G419_05622	1.996e-25	111.0	COG3209@1|root,COG3210@1|root,COG4842@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,COG4842@2|Bacteria,2GMBB@201174|Actinobacteria,4FY52@85025|Nocardiaceae	201174|Actinobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
CMS1_k127_4878798_5	1121456.ATVA01000017_gene179	9.315e-11	66.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42QUN@68525|delta/epsilon subdivisions,2WN6Q@28221|Deltaproteobacteria,2M8B2@213115|Desulfovibrionales	28221|Deltaproteobacteria	OU	TIGRFAM signal peptide peptidase SppA, 36K type	sppA2	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
CMS1_k127_4878798_0	720554.Clocl_0329	7.452e-83	282.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,3WHY1@541000|Ruminococcaceae	186801|Clostridia	S	MazG family	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
CMS1_k127_4878798_3	641143.HMPREF9331_00543	4.006e-26	124.0	COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,1HYP9@117743|Flavobacteriia,1EQ60@1016|Capnocytophaga	976|Bacteroidetes	S	Oxygen tolerance	batD	-	-	-	-	-	-	-	-	-	-	-	BatD,TPR_2
CMS1_k127_4878798_7	1236508.BAKF01000001_gene53	0.0001041	53.0	COG0457@1|root,COG3103@1|root,COG0457@2|Bacteria,COG3103@2|Bacteria,4NERG@976|Bacteroidetes,2FMK5@200643|Bacteroidia	976|Bacteroidetes	T	Tetratricopeptide repeat protein	batD	-	-	-	-	-	-	-	-	-	-	-	BatD,TPR_2
CMS1_k127_4878798_2	1379698.RBG1_1C00001G1774	8.625e-56	208.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2NP2F@2323|unclassified Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
CMS1_k127_4878798_1	880073.Calab_2474	1.565e-69	248.0	COG2304@1|root,COG2304@2|Bacteria,2NNYH@2323|unclassified Bacteria	2|Bacteria	NU	von Willebrand factor (vWF) type A domain	batA	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
CMS1_k127_4878798_6	888059.HMPREF9071_1652	2.417e-08	65.0	COG3088@1|root,COG3088@2|Bacteria,4NGHU@976|Bacteroidetes,1HY3G@117743|Flavobacteriia,1EQSU@1016|Capnocytophaga	976|Bacteroidetes	O	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4878798_4	319236.JCM19294_2789	7.686e-20	94.0	COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,1HX4X@117743|Flavobacteriia,3HJVT@363408|Nonlabens	976|Bacteroidetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
CMS1_k127_4897876_4	1121104.AQXH01000001_gene1050	1.358e-67	241.0	COG1160@1|root,COG1160@2|Bacteria,4NE2J@976|Bacteroidetes,1IR18@117747|Sphingobacteriia	976|Bacteroidetes	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
CMS1_k127_4897876_5	864565.HMPREF0379_1631	6.472e-63	221.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,25QKA@186804|Peptostreptococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
CMS1_k127_4897876_7	1111134.HMPREF1253_1856	2.167e-11	68.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,22HRF@1570339|Peptoniphilaceae	186801|Clostridia	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
CMS1_k127_4897876_1	880073.Calab_0453	2.344e-108	370.0	COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
CMS1_k127_4897876_3	589865.DaAHT2_0430	3.652e-74	255.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2MNE9@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
CMS1_k127_4897876_6	237368.SCABRO_01428	2.73e-48	181.0	COG0637@1|root,COG0637@2|Bacteria,2IZIM@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_4897876_2	744872.Spica_0983	4.591e-105	352.0	COG1181@1|root,COG1181@2|Bacteria,2J611@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
CMS1_k127_4897876_0	247490.KSU1_C1278	2.986e-133	436.0	COG0527@1|root,COG0527@2|Bacteria,2IY8N@203682|Planctomycetes	203682|Planctomycetes	E	aspartate kinase, monofunctional class	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
CMS1_k127_4921829_3	1121324.CLIT_13c01750	6.086e-24	103.0	COG0864@1|root,COG0864@2|Bacteria,1VF9M@1239|Firmicutes,24QVJ@186801|Clostridia	186801|Clostridia	K	Iron-only hydrogenase system regulator	-	-	-	-	-	-	-	-	-	-	-	-	NikR_C
CMS1_k127_4921829_0	574087.Acear_1233	3.014e-204	647.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia,3WAE0@53433|Halanaerobiales	186801|Clostridia	C	Biotin and Thiamin Synthesis associated	thiH	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
CMS1_k127_4921829_1	665571.STHERM_c17980	1.642e-116	389.0	COG1027@1|root,COG1027@2|Bacteria,2J5AF@203691|Spirochaetes	203691|Spirochaetes	E	Aspartate ammonia-lyase	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
CMS1_k127_4921829_2	479436.Vpar_1846	6.754e-25	109.0	COG1160@1|root,COG1160@2|Bacteria,1UI84@1239|Firmicutes,4H9BS@909932|Negativicutes	909932|Negativicutes	S	Hydrogenase maturation GTPase HydF	hydF	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
CMS1_k127_4944702_2	1397666.RS24_01044	2.147e-10	65.0	COG2076@1|root,COG2076@2|Bacteria,1Q8Q2@1224|Proteobacteria,2UXJ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Small Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Multi_Drug_Res
CMS1_k127_4944702_1	1150621.SMUL_2536	1.445e-54	198.0	COG0560@1|root,COG0560@2|Bacteria,1RKIX@1224|Proteobacteria,42SHN@68525|delta/epsilon subdivisions,2YN70@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
CMS1_k127_4944702_0	387093.SUN_1522	3.282e-84	287.0	COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,42PEU@68525|delta/epsilon subdivisions,2YP21@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
CMS1_k127_4944702_3	393480.FNP_1306	7.76e-07	55.0	COG2510@1|root,COG2510@2|Bacteria,37AH3@32066|Fusobacteria	32066|Fusobacteria	S	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
CMS1_k127_4945893_0	1280692.AUJL01000029_gene1885	4.06e-95	321.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,36DHM@31979|Clostridiaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS1_k127_4945893_1	1045858.Bint_2833	1.73e-73	264.0	COG0793@1|root,COG0793@2|Bacteria,2J5QD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
CMS1_k127_4945893_3	1120953.AUBH01000015_gene2799	2.167e-11	76.0	COG3391@1|root,COG3391@2|Bacteria,1R4KD@1224|Proteobacteria,1S1C1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4842
CMS1_k127_4945893_2	1499967.BAYZ01000117_gene3327	4.662e-13	70.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM-2	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
CMS1_k127_496261_1	395493.BegalDRAFT_2227	3.538e-64	236.0	COG0740@1|root,COG0740@2|Bacteria	2|Bacteria	OU	serine-type endopeptidase activity	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS1_k127_496261_0	665571.STHERM_c13210	1.386e-150	491.0	COG3604@1|root,COG3604@2|Bacteria,2J5TK@203691|Spirochaetes	203691|Spirochaetes	KT	Fis Family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
CMS1_k127_4963674_0	515635.Dtur_1752	2.817e-49	192.0	COG1609@1|root,COG2199@1|root,COG1609@2|Bacteria,COG2199@2|Bacteria	2|Bacteria	T	diguanylate cyclase activity	-	-	-	ko:K02103,ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	GAF,GGDEF,Peripla_BP_3
CMS1_k127_4974038_0	28072.Nos7524_5161	3.246e-91	317.0	COG0641@1|root,COG0641@2|Bacteria,1FZZY@1117|Cyanobacteria,1HRV7@1161|Nostocales	1117|Cyanobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_4974038_1	32057.KB217478_gene1508	2.263e-33	152.0	COG1572@1|root,COG1572@2|Bacteria,1GE0K@1117|Cyanobacteria,1HRW1@1161|Nostocales	1117|Cyanobacteria	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
CMS1_k127_4974602_0	931276.Cspa_c24830	1.718e-17	85.0	COG0457@1|root,COG0457@2|Bacteria,1VDZT@1239|Firmicutes	1239|Firmicutes	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_4974602_1	515635.Dtur_1524	7.657e-17	83.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS1_k127_4974602_2	1514668.JOOA01000001_gene181	4.958e-07	55.0	COG1598@1|root,COG1598@2|Bacteria,1VAKM@1239|Firmicutes,24K5X@186801|Clostridia,3WKAK@541000|Ruminococcaceae	186801|Clostridia	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	ko:K18843	-	-	-	-	ko00000,ko02048	-	-	-	HicB_lk_antitox
CMS1_k127_4974602_3	1123507.ATVQ01000005_gene81	5.384e-06	49.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,1W7W1@1268|Micrococcaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
CMS1_k127_5014983_5	349521.HCH_05413	4.599e-124	415.0	COG0715@1|root,COG2885@1|root,COG0715@2|Bacteria,COG2885@2|Bacteria,1R687@1224|Proteobacteria,1S19R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MP	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,NMT1_2,OmpA
CMS1_k127_5014983_13	1123053.AUDG01000023_gene649	1.493e-47	180.0	COG2304@1|root,COG2304@2|Bacteria,1RGCN@1224|Proteobacteria,1S5GI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
CMS1_k127_5014983_2	335543.Sfum_3489	2.87e-167	542.0	COG0715@1|root,COG2885@1|root,COG0715@2|Bacteria,COG2885@2|Bacteria,1QU25@1224|Proteobacteria,42YRH@68525|delta/epsilon subdivisions,2WUGB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
CMS1_k127_5014983_7	335543.Sfum_3490	7.491e-116	380.0	COG1116@1|root,COG1116@2|Bacteria,1PFBK@1224|Proteobacteria,439WT@68525|delta/epsilon subdivisions,2WURT@28221|Deltaproteobacteria,2MS1J@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
CMS1_k127_5014983_11	335543.Sfum_3491	1.601e-97	325.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,42PJ5@68525|delta/epsilon subdivisions,2WTND@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
CMS1_k127_5014983_3	335543.Sfum_3492	1.369e-132	431.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,42NMD@68525|delta/epsilon subdivisions,2WUNU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	-
CMS1_k127_5014983_10	864702.OsccyDRAFT_2650	9.403e-100	342.0	COG0464@1|root,COG2319@1|root,COG0464@2|Bacteria,COG2319@2|Bacteria,1G062@1117|Cyanobacteria,1HA8K@1150|Oscillatoriales	1117|Cyanobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_2
CMS1_k127_5014983_6	1168289.AJKI01000002_gene2351	6.399e-124	407.0	COG3853@1|root,COG3853@2|Bacteria,4NFKY@976|Bacteroidetes	976|Bacteroidetes	P	Belongs to the TelA family	-	-	-	-	-	-	-	-	-	-	-	-	TelA
CMS1_k127_5014983_12	1237149.C900_04889	7.783e-81	279.0	COG0668@1|root,COG0668@2|Bacteria,4NF28@976|Bacteroidetes,47P8R@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
CMS1_k127_5014983_9	1231241.Mc24_08699	1.004e-103	347.0	COG0598@1|root,COG0598@2|Bacteria,2GCUD@200918|Thermotogae	200918|Thermotogae	P	Mediates influx of magnesium ions	corA	GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
CMS1_k127_5014983_16	324925.Ppha_0360	2.474e-35	143.0	COG0745@1|root,COG2202@1|root,COG3829@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,1FF5G@1090|Chlorobi	1090|Chlorobi	KT	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9
CMS1_k127_5014983_8	237368.SCABRO_01669	1.566e-104	347.0	COG0379@1|root,COG0379@2|Bacteria,2IXB1@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
CMS1_k127_5014983_14	243090.RB7615	2.698e-38	147.0	COG0454@1|root,COG0456@2|Bacteria,2J11J@203682|Planctomycetes	203682|Planctomycetes	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_5014983_15	469381.Dpep_0131	1.408e-35	139.0	COG1959@1|root,COG1959@2|Bacteria,3TBP1@508458|Synergistetes	508458|Synergistetes	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
CMS1_k127_5014983_4	665571.STHERM_c12900	9.412e-126	409.0	COG0031@1|root,COG0031@2|Bacteria,2J5EE@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
CMS1_k127_5014983_1	65093.PCC7418_0604	1.646e-200	631.0	COG2873@1|root,COG2873@2|Bacteria,1G4EH@1117|Cyanobacteria	1117|Cyanobacteria	E	O-acetylhomoserine sulfhydrylase	met17	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
CMS1_k127_5014983_18	368407.Memar_2463	8.661e-05	49.0	COG3042@1|root,arCOG12676@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF333)	-	-	-	ko:K09712	-	-	-	-	ko00000	-	-	-	DUF333
CMS1_k127_5014983_0	933262.AXAM01000019_gene1089	1.302e-259	810.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MHVG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2834	Prismane
CMS1_k127_5014983_17	86416.Clopa_2028	1.469e-18	85.0	COG1942@1|root,COG1942@2|Bacteria,1VHRB@1239|Firmicutes,24QWT@186801|Clostridia,36TAP@31979|Clostridiaceae	186801|Clostridia	S	Tautomerase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Tautomerase_2
CMS1_k127_5033415_0	265729.GS18_0221285	1.185e-26	111.0	COG0500@1|root,COG2226@2|Bacteria,1VHYI@1239|Firmicutes,4IPZT@91061|Bacilli	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
CMS1_k127_5033415_1	984262.SGRA_3241	0.0005026	49.0	28UPH@1|root,2ZGTX@2|Bacteria,4P8E4@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5042651_2	1485545.JQLW01000001_gene1466	7.789e-10	70.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria	1224|Proteobacteria	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
CMS1_k127_5042651_1	755732.Fluta_1203	1.682e-22	111.0	COG2385@1|root,COG2385@2|Bacteria,4NG21@976|Bacteroidetes,1I7GW@117743|Flavobacteriia,2PAW4@246874|Cryomorphaceae	976|Bacteroidetes	D	Stage II sporulation protein	lytB	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	DUF4922,Glycos_transf_2,SpoIID
CMS1_k127_5042651_0	1121121.KB894286_gene2343	6.006e-63	227.0	COG3153@1|root,COG3153@2|Bacteria,1UIPH@1239|Firmicutes,4ISP0@91061|Bacilli,26VCF@186822|Paenibacillaceae	91061|Bacilli	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
CMS1_k127_5044590_0	632245.CLP_1483	1.077e-79	276.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,36EAK@31979|Clostridiaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS1_k127_5044590_1	1294265.JCM21738_5450	3.141e-35	139.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,4HIIF@91061|Bacilli,1ZGBU@1386|Bacillus	91061|Bacilli	S	ATPase or kinase	ydiB	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
CMS1_k127_5044590_2	257314.LJ_0434	4.781e-27	119.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4HHD7@91061|Bacilli,3F3WV@33958|Lactobacillaceae	91061|Bacilli	O	Universal bacterial protein YeaZ	yeaZ	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
CMS1_k127_5044590_3	525255.HMPREF0077_0312	1.015e-22	102.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,22H37@1570339|Peptoniphilaceae	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
CMS1_k127_5050786_1	880072.Desac_1158	1.26e-16	82.0	COG1504@1|root,COG1504@2|Bacteria,1NCBP@1224|Proteobacteria,42VUI@68525|delta/epsilon subdivisions,2WRJY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
CMS1_k127_5050786_0	247490.KSU1_D0121	2.949e-185	586.0	COG0538@1|root,COG0538@2|Bacteria,2J51C@203682|Planctomycetes	203682|Planctomycetes	C	Isocitrate/isopropylmalate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
CMS1_k127_5050786_3	1123236.KB899376_gene506	7.738e-05	50.0	COG1403@1|root,COG1403@2|Bacteria,1NEG4@1224|Proteobacteria	1224|Proteobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
CMS1_k127_5050786_2	755732.Fluta_3992	7.584e-10	72.0	COG2931@1|root,COG2931@2|Bacteria,4PM4Z@976|Bacteroidetes,1I3A1@117743|Flavobacteriia	976|Bacteroidetes	Q	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122
CMS1_k127_5062298_0	1123274.KB899417_gene2065	5.867e-126	413.0	COG0624@1|root,COG0624@2|Bacteria,2J61U@203691|Spirochaetes	203691|Spirochaetes	E	Peptidase dimerisation domain	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
CMS1_k127_5062298_1	573413.Spirs_1194	1.595e-67	233.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_5062298_2	1379858.N508_00435	1.017e-64	228.0	COG1272@1|root,COG1272@2|Bacteria,2GFPI@200930|Deferribacteres	200930|Deferribacteres	S	channel protein, hemolysin III family	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
CMS1_k127_5062298_4	903818.KI912269_gene370	8.405e-40	159.0	COG4099@1|root,COG4099@2|Bacteria	2|Bacteria	F	phospholipase Carboxylesterase	-	-	3.5.4.40	ko:K18286	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_2,Abhydrolase_8,Peptidase_S9
CMS1_k127_5062298_3	717231.Flexsi_2287	1.24e-41	164.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
CMS1_k127_5066772_1	331678.Cphamn1_0263	8.931e-57	205.0	COG1208@1|root,COG1208@2|Bacteria,1FDKD@1090|Chlorobi	1090|Chlorobi	M	PFAM Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
CMS1_k127_5066772_0	945713.IALB_2169	1.448e-100	344.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
CMS1_k127_5066772_2	1485545.JQLW01000007_gene742	1.555e-11	75.0	2DIWG@1|root,3049N@2|Bacteria,1R88E@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
CMS1_k127_5071582_4	1499967.BAYZ01000028_gene1277	2.069e-28	117.0	COG1534@1|root,COG1534@2|Bacteria	2|Bacteria	J	preribosome binding	yhbY	GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
CMS1_k127_5071582_0	511051.CSE_09580	5.413e-195	618.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
CMS1_k127_5071582_2	511051.CSE_09590	3.905e-116	379.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	pyrK_1	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
CMS1_k127_5071582_3	1348583.ATLH01000006_gene1084	2.361e-34	135.0	COG2755@1|root,COG2755@2|Bacteria,4NQAK@976|Bacteroidetes,1I340@117743|Flavobacteriia,1F9JA@104264|Cellulophaga	976|Bacteroidetes	E	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
CMS1_k127_5071582_1	509191.AEDB02000003_gene1043	1.175e-153	501.0	COG2199@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5002@2|Bacteria,1UVSG@1239|Firmicutes,24B7R@186801|Clostridia	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_5080683_2	1410608.JNKX01000002_gene1893	1.969e-25	115.0	2DBB3@1|root,2Z85F@2|Bacteria,4NKCY@976|Bacteroidetes,2FPU7@200643|Bacteroidia,4AKZQ@815|Bacteroidaceae	976|Bacteroidetes	S	Domain of unknown function (4846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4846
CMS1_k127_5080683_0	1134474.O59_000008	1.106e-98	328.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1FFWQ@10|Cellvibrio	1236|Gammaproteobacteria	E	Serine acetyltransferase, N-terminal	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009314,GO:0009333,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
CMS1_k127_5080683_1	1304885.AUEY01000087_gene94	5.372e-64	230.0	COG2199@1|root,COG3706@2|Bacteria,1RERI@1224|Proteobacteria,42S3X@68525|delta/epsilon subdivisions,2WNF2@28221|Deltaproteobacteria,2MNCH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2982	GGDEF
CMS1_k127_5084617_1	387093.SUN_0863	3.32e-43	173.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,CotH,F5_F8_type_C,FIVAR,LTD,Metallophos
CMS1_k127_5084617_0	710111.FraQA3DRAFT_0449	1.242e-53	204.0	2C69W@1|root,2Z7HR@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4474)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4474
CMS1_k127_5098043_1	1005048.CFU_0927	8.176e-94	319.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,473JU@75682|Oxalobacteraceae	28216|Betaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
CMS1_k127_5098043_3	237368.SCABRO_01102	6.339e-36	142.0	COG0835@1|root,COG0835@2|Bacteria,2J076@203682|Planctomycetes	203682|Planctomycetes	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS1_k127_5098043_4	439235.Dalk_4482	2.152e-32	129.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,42SAC@68525|delta/epsilon subdivisions,2WP7J@28221|Deltaproteobacteria,2MK8Q@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	cheY34H-1	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
CMS1_k127_5098043_0	926561.KB900617_gene1203	1.119e-174	571.0	COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,3WB3C@53433|Halanaerobiales	186801|Clostridia	T	Signal transducing histidine kinase, homodimeric domain	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
CMS1_k127_5098043_2	265072.Mfla_2154	7.256e-73	267.0	COG0840@1|root,COG5000@1|root,COG0840@2|Bacteria,COG5000@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,2KKQK@206350|Nitrosomonadales	206350|Nitrosomonadales	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
CMS1_k127_5113853_0	1449050.JNLE01000003_gene2067	5.068e-285	893.0	COG0331@1|root,COG2070@1|root,COG0331@2|Bacteria,COG2070@2|Bacteria,1UG0E@1239|Firmicutes,25F9X@186801|Clostridia,36GGS@31979|Clostridiaceae	186801|Clostridia	I	Acyl transferase domain	-	-	-	ko:K15329,ko:K15355	-	-	-	-	ko00000,ko01008	-	-	-	Acyl_transf_1,NMO
CMS1_k127_5113853_1	1395587.P364_0119595	5.499e-189	608.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4I2RT@91061|Bacilli,26UUG@186822|Paenibacillaceae	91061|Bacilli	Q	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt
CMS1_k127_5117435_0	580331.Thit_1508	6.392e-166	534.0	COG1362@1|root,COG1362@2|Bacteria,1TP6G@1239|Firmicutes,2486Y@186801|Clostridia,42F3Q@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M18, aminopeptidase I	apeA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M18
CMS1_k127_5117435_1	1128398.Curi_c09590	7.308e-10	70.0	COG1716@1|root,COG1716@2|Bacteria,1VF0E@1239|Firmicutes,25MV8@186801|Clostridia,26BPA@186813|unclassified Clostridiales	186801|Clostridia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
CMS1_k127_5117435_2	631362.Thi970DRAFT_03801	0.0003343	52.0	COG2304@1|root,COG2304@2|Bacteria,1R7GI@1224|Proteobacteria,1S00S@1236|Gammaproteobacteria,1WVZN@135613|Chromatiales	135613|Chromatiales	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
CMS1_k127_5143440_3	861455.HMPREF9184_01170	5.108e-28	125.0	arCOG12656@1|root,32WNH@2|Bacteria,1VG6P@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5143440_0	406327.Mevan_0106	1.391e-89	314.0	COG1353@1|root,arCOG02666@2157|Archaea,2Y1FK@28890|Euryarchaeota,23RFR@183939|Methanococci	183939|Methanococci	V	TIGRFAM CRISPR-associated protein, Crm2 family	-	-	-	ko:K19076	-	-	-	-	ko00000,ko02048	-	-	-	DUF3692
CMS1_k127_5143440_2	1121289.JHVL01000034_gene2601	4.899e-50	190.0	COG1769@1|root,COG1769@2|Bacteria,1VG9K@1239|Firmicutes,24Q05@186801|Clostridia,36RWT@31979|Clostridiaceae	186801|Clostridia	L	CRISPR-associated protein (Cas_Cmr3)	-	-	-	ko:K09127	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cmr3
CMS1_k127_5143440_1	926692.AZYG01000067_gene2060	3.842e-67	237.0	COG1336@1|root,COG1336@2|Bacteria,1V1RI@1239|Firmicutes,24NF6@186801|Clostridia	186801|Clostridia	L	RAMP superfamily	-	-	-	ko:K09000	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
CMS1_k127_5143440_4	944481.JAFP01000001_gene1103	7.532e-19	91.0	COG3337@1|root,COG3337@2|Bacteria	2|Bacteria	L	CRISPR-associated protein (Cas_Cmr5)	cmr5	-	-	ko:K19141	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cmr5
CMS1_k127_5145866_1	1123008.KB905693_gene1145	9.512e-36	139.0	COG4953@1|root,COG4953@2|Bacteria,4NEG5@976|Bacteroidetes,2FNUH@200643|Bacteroidia,22W9J@171551|Porphyromonadaceae	976|Bacteroidetes	M	Penicillin-Binding Protein C-terminus Family	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
CMS1_k127_5145866_0	1121129.KB903367_gene2699	2.076e-138	454.0	COG1502@1|root,COG1502@2|Bacteria,4NE2W@976|Bacteroidetes,2FMEA@200643|Bacteroidia,22W66@171551|Porphyromonadaceae	976|Bacteroidetes	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
CMS1_k127_5145866_2	1305737.JAFX01000001_gene1341	9.869e-27	113.0	COG4068@1|root,COG4068@2|Bacteria,4NQ3Z@976|Bacteroidetes,47QXI@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2116
CMS1_k127_5145866_3	391603.FBALC1_01157	7.349e-25	106.0	COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,1I2UG@117743|Flavobacteriia	976|Bacteroidetes	L	single-stranded DNA-binding protein	ssb1	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS1_k127_5146844_1	1410632.JHWW01000014_gene300	3.608e-152	488.0	COG0722@1|root,COG0722@2|Bacteria,1TQI4@1239|Firmicutes,24842@186801|Clostridia,27JFA@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroH	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS07240	DAHP_synth_1
CMS1_k127_5146844_0	926549.KI421517_gene2115	1.868e-233	743.0	COG1032@1|root,COG1032@2|Bacteria,4NETM@976|Bacteroidetes,47JMU@768503|Cytophagia	976|Bacteroidetes	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
CMS1_k127_5146844_4	573413.Spirs_0208	1.505e-41	158.0	COG0727@1|root,COG0727@2|Bacteria,2JATI@203691|Spirochaetes	203691|Spirochaetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
CMS1_k127_5146844_2	795359.TOPB45_0257	5.355e-84	293.0	COG0265@1|root,COG0265@2|Bacteria,2GHRY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
CMS1_k127_5146844_3	403833.Pmob_1359	3.709e-62	222.0	COG0846@1|root,COG0846@2|Bacteria,2GCRV@200918|Thermotogae	200918|Thermotogae	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
CMS1_k127_5153074_0	1121456.ATVA01000011_gene1532	3.322e-131	429.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1RGKE@1224|Proteobacteria,42QI9@68525|delta/epsilon subdivisions,2WIV3@28221|Deltaproteobacteria,2M9A9@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,Lactamase_B_2
CMS1_k127_5153074_1	742817.HMPREF9449_02421	9.83e-24	116.0	COG1305@1|root,COG1305@2|Bacteria,4NI6P@976|Bacteroidetes,2FPYJ@200643|Bacteroidia,22XFT@171551|Porphyromonadaceae	976|Bacteroidetes	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,Transglut_core
CMS1_k127_5162499_3	759914.BP951000_1308	8.38e-12	68.0	COG0316@1|root,COG0316@2|Bacteria	2|Bacteria	S	protein maturation	iscA1	-	6.3.5.11,6.3.5.9	ko:K02224,ko:K13628,ko:K15724	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000,ko03016	-	-	-	Fe-S_biosyn
CMS1_k127_5162499_0	243275.TDE_0844	4.495e-267	847.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J6C2@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C
CMS1_k127_5162499_2	1123274.KB899419_gene1996	8.271e-79	274.0	2F0EQ@1|root,33THS@2|Bacteria,2J5ZQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5162499_1	889378.Spiaf_0164	3.041e-226	718.0	2EZDZ@1|root,33SJ6@2|Bacteria,2J6M2@203691|Spirochaetes	203691|Spirochaetes	S	Cytoplasmic filament protein A	cfpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5162499_4	103690.17131133	3.012e-07	62.0	COG2304@1|root,COG2304@2|Bacteria,1GE29@1117|Cyanobacteria,1HQQ8@1161|Nostocales	1117|Cyanobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
CMS1_k127_5169383_1	574087.Acear_2243	3.359e-109	367.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,3WAQ7@53433|Halanaerobiales	186801|Clostridia	J	Arginyl tRNA synthetase N terminal domain	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
CMS1_k127_5169383_0	665571.STHERM_c10940	7.11e-114	392.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
CMS1_k127_5170555_2	880070.Cycma_4843	4.383e-05	52.0	COG1595@1|root,COG1595@2|Bacteria,4NW2Z@976|Bacteroidetes,47W88@768503|Cytophagia	976|Bacteroidetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_5170555_1	1118054.CAGW01000050_gene1190	1.577e-51	191.0	COG1119@1|root,COG1119@2|Bacteria,1TRR4@1239|Firmicutes,4HB4U@91061|Bacilli,26QE5@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter, ATP-binding protein	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
CMS1_k127_5170555_0	1304888.ATWF01000001_gene1276	4.994e-142	479.0	COG0004@1|root,COG0004@2|Bacteria,2GER5@200930|Deferribacteres	2|Bacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,EAL,GGDEF,HATPase_c,HisKA,HisKA_3,MCPsignal,PAS_9,Response_reg
CMS1_k127_5173541_0	945713.IALB_2697	3.665e-255	811.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	fadD	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
CMS1_k127_5173541_3	1353529.M899_3007	2.928e-30	123.0	COG1832@1|root,COG1832@2|Bacteria,1PUW7@1224|Proteobacteria,42T5D@68525|delta/epsilon subdivisions,2WPHZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
CMS1_k127_5173541_2	111780.Sta7437_2744	6.294e-55	205.0	COG0451@1|root,COG0451@2|Bacteria,1G2DP@1117|Cyanobacteria,3VIUA@52604|Pleurocapsales	1117|Cyanobacteria	GM	PFAM NAD dependent epimerase dehydratase family	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
CMS1_k127_5173541_1	755178.Cyan10605_0841	2.3e-64	228.0	COG3437@1|root,COG5001@1|root,COG3437@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
CMS1_k127_5177077_0	1201293.AKXQ01000015_gene1337	5.593e-239	759.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CMS1_k127_5177077_1	1286632.P278_25330	3.971e-70	244.0	COG2360@1|root,COG2360@2|Bacteria,4NG3A@976|Bacteroidetes,1HY9J@117743|Flavobacteriia	976|Bacteroidetes	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
CMS1_k127_5177077_2	880073.Calab_2372	1.282e-08	67.0	COG1729@1|root,COG1729@2|Bacteria,2NQ0B@2323|unclassified Bacteria	2|Bacteria	S	Outer membrane lipoprotein	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
CMS1_k127_5177077_3	889378.Spiaf_1054	1.867e-06	59.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	3.2.1.51	ko:K01206,ko:K07114,ko:K07126	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko02000,ko04147	1.A.13.2.2,1.A.13.2.3	GH29	-	FecR,SPOR,TPR_6
CMS1_k127_5178563_7	192952.MM_1041	6.546e-20	95.0	COG0701@1|root,arCOG02712@2157|Archaea,2XT2F@28890|Euryarchaeota,2NAE3@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
CMS1_k127_5178563_9	909663.KI867150_gene2060	8.347e-13	74.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2WP4D@28221|Deltaproteobacteria,2MQQW@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Hydrogenase maturation protease	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
CMS1_k127_5178563_1	693661.Arcve_1567	1.362e-147	489.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
CMS1_k127_5178563_4	429009.Adeg_2015	2.662e-50	182.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
CMS1_k127_5178563_2	880073.Calab_3044	1.225e-106	355.0	COG1941@1|root,COG1941@2|Bacteria,2NQP6@2323|unclassified Bacteria	2|Bacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_lg_C,Fer4,FlpD,Oxidored_q6
CMS1_k127_5178563_0	880073.Calab_3043	1.15e-203	644.0	COG3259@1|root,COG3259@2|Bacteria,2NQGS@2323|unclassified Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
CMS1_k127_5178563_8	946483.Cenrod_2149	1.841e-13	72.0	COG0425@1|root,COG0425@2|Bacteria,1P4MT@1224|Proteobacteria	1224|Proteobacteria	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
CMS1_k127_5178563_3	32057.KB217478_gene3886	7.513e-105	351.0	COG0309@1|root,COG0309@2|Bacteria,1G1Z7@1117|Cyanobacteria,1HKMD@1161|Nostocales	1117|Cyanobacteria	O	TIGRFAM hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
CMS1_k127_5178563_5	468059.AUHA01000003_gene1902	4.393e-43	178.0	COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia	976|Bacteroidetes	MU	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40,TPR_16,TPR_2,TPR_8
CMS1_k127_5178563_10	1121859.KB890739_gene2674	0.0001703	53.0	COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,47JN3@768503|Cytophagia	976|Bacteroidetes	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
CMS1_k127_5180289_0	880073.Calab_1177	2.786e-176	562.0	COG1260@1|root,COG1260@2|Bacteria,2NP2I@2323|unclassified Bacteria	2|Bacteria	I	Myo-inositol-1-phosphate synthase	ino1	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
CMS1_k127_5180289_1	880073.Calab_0213	8.767e-84	287.0	COG0530@1|root,COG0530@2|Bacteria,2NPPD@2323|unclassified Bacteria	2|Bacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
CMS1_k127_5180289_2	485918.Cpin_1364	3.029e-08	60.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
CMS1_k127_5191434_0	926562.Oweho_0745	3.794e-27	126.0	COG3014@1|root,COG3014@2|Bacteria,4NIIU@976|Bacteroidetes,1I0JV@117743|Flavobacteriia,2PBKZ@246874|Cryomorphaceae	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	TPR_2
CMS1_k127_5191434_1	575788.VS_2076	1.381e-14	81.0	COG3417@1|root,COG3417@2|Bacteria,1RA6V@1224|Proteobacteria,1S30E@1236|Gammaproteobacteria,1XUJ6@135623|Vibrionales	135623|Vibrionales	M	Collagen-binding surface adhesin SpaP (Antigen I II family)	lpoB	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
CMS1_k127_5191434_2	1499967.BAYZ01000096_gene4306	4.357e-12	80.0	COG3119@1|root,COG5652@1|root,COG3119@2|Bacteria,COG5652@2|Bacteria,2NRYS@2323|unclassified Bacteria	2|Bacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4976,Sulfatase,VanZ
CMS1_k127_5195528_0	1538295.JY96_13910	2.303e-125	426.0	COG1361@1|root,COG1686@1|root,COG1361@2|Bacteria,COG1686@2|Bacteria,1PWJU@1224|Proteobacteria,2W081@28216|Betaproteobacteria,1KN3Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Peptidase family C25	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25,TSP_3
CMS1_k127_5202489_0	665571.STHERM_c19480	1.329e-42	164.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	potE	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2,SLC12
CMS1_k127_5202489_1	926561.KB900617_gene2050	3.058e-16	91.0	2DP2M@1|root,3309H@2|Bacteria,1V5H4@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5202860_1	243275.TDE_2247	3.186e-22	96.0	COG2337@1|root,COG2337@2|Bacteria,2J8NW@203691|Spirochaetes	203691|Spirochaetes	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
CMS1_k127_5202860_3	221288.JH992901_gene4366	2.287e-10	63.0	COG4679@1|root,COG4679@2|Bacteria,1GDRR@1117|Cyanobacteria	1117|Cyanobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
CMS1_k127_5202860_2	1078085.HMPREF1210_02086	5.405e-11	67.0	COG1476@1|root,COG1476@2|Bacteria,1VEKB@1239|Firmicutes,4HNIW@91061|Bacilli	91061|Bacilli	K	Transcriptional	ansR1	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
CMS1_k127_5202860_0	491205.JARQ01000011_gene1304	1.381e-22	99.0	2CATT@1|root,32QXK@2|Bacteria,4P28N@976|Bacteroidetes,1I7SQ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5204296_0	1242864.D187_008305	1.324e-209	688.0	COG3408@1|root,COG3408@2|Bacteria,1QWGV@1224|Proteobacteria	1224|Proteobacteria	G	hydrolase of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,GDE_C
CMS1_k127_5204296_2	985665.HPL003_21350	1.142e-09	72.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria,1V0U1@1239|Firmicutes,4HV3E@91061|Bacilli,26RZU@186822|Paenibacillaceae	91061|Bacilli	G	Alpha-amylase	aml1	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CBM53,CBM_35,CHB_HEX_C_1
CMS1_k127_5204296_1	316067.Geob_3475	9.725e-120	395.0	COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,42NZA@68525|delta/epsilon subdivisions,2WK1T@28221|Deltaproteobacteria,43U4C@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Domain of unknown function (DUF3524)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glycos_transf_1
CMS1_k127_5204296_3	871585.BDGL_002784	6.114e-09	67.0	2EPHR@1|root,33H4C@2|Bacteria,1N353@1224|Proteobacteria,1SDW7@1236|Gammaproteobacteria,3NIZG@468|Moraxellaceae	1236|Gammaproteobacteria	S	Putative general bacterial porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_7
CMS1_k127_5215411_1	439235.Dalk_2041	1.26e-24	106.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_3,PAS_9,Response_reg
CMS1_k127_5215411_2	1123511.KB905853_gene3732	1.187e-12	76.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,4H28M@909932|Negativicutes	909932|Negativicutes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
CMS1_k127_5215411_0	1004149.AFOE01000006_gene2056	4.531e-29	126.0	COG2819@1|root,COG2819@2|Bacteria,4NFYP@976|Bacteroidetes,1HZC2@117743|Flavobacteriia	976|Bacteroidetes	S	Putative esterase	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
CMS1_k127_5218566_1	7668.SPU_012060-tr	8.712e-40	164.0	COG0666@1|root,KOG0504@2759|Eukaryota,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BGGV@33208|Metazoa,3CT1S@33213|Bilateria	33208|Metazoa	M	ankyrin 3, node of Ranvier (ankyrin G)	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,ZU5
CMS1_k127_5218566_0	452471.Aasi_1435	3.123e-64	237.0	COG0666@1|root,COG1196@1|root,COG0666@2|Bacteria,COG1196@2|Bacteria,4NEYY@976|Bacteroidetes,47MVD@768503|Cytophagia	976|Bacteroidetes	U	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,SHOCT,SecA_DEAD
CMS1_k127_5218566_2	1304888.ATWF01000002_gene36	7.615e-28	115.0	COG1227@1|root,COG1227@2|Bacteria,2GEVZ@200930|Deferribacteres	200930|Deferribacteres	C	DHHA2	-	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
CMS1_k127_5226322_10	1280688.AUJB01000008_gene781	1.095e-16	96.0	COG4676@1|root,COG4676@2|Bacteria,1VF8Z@1239|Firmicutes,24S72@186801|Clostridia	186801|Clostridia	V	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11
CMS1_k127_5226322_6	243231.GSU3016	8.934e-72	277.0	COG0823@1|root,COG2885@1|root,COG3291@1|root,COG4412@1|root,COG5492@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,COG5492@2|Bacteria,1PMFY@1224|Proteobacteria,42Y8D@68525|delta/epsilon subdivisions,2WUNZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Chitobiase/beta-hexosaminidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
CMS1_k127_5226322_5	1304885.AUEY01000034_gene1889	4.732e-92	327.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MMRP@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS1_k127_5226322_8	1499967.BAYZ01000016_gene6490	7.375e-39	156.0	COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
CMS1_k127_5226322_4	1208583.COMX_04745	8.376e-96	321.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria,2JPTI@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
CMS1_k127_5226322_2	1408473.JHXO01000005_gene1613	3.561e-160	516.0	COG0477@1|root,COG2814@2|Bacteria,4NFRE@976|Bacteroidetes	976|Bacteroidetes	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
CMS1_k127_5226322_3	759914.BP951000_0805	1.452e-132	436.0	COG0617@1|root,COG0617@2|Bacteria,2J5ZC@203691|Spirochaetes	203691|Spirochaetes	H	PolyA polymerase	papS	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
CMS1_k127_5226322_9	526224.Bmur_2633	3.905e-30	137.0	COG4733@1|root,COG4733@2|Bacteria,2JBHZ@203691|Spirochaetes	203691|Spirochaetes	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,fn3
CMS1_k127_5226322_7	903814.ELI_4124	2.444e-51	185.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,25WQ2@186806|Eubacteriaceae	186801|Clostridia	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
CMS1_k127_5226322_1	1148.1001357	1.705e-197	624.0	COG0017@1|root,COG0017@2|Bacteria,1G015@1117|Cyanobacteria,1H4FG@1142|Synechocystis	1117|Cyanobacteria	J	tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
CMS1_k127_5226322_0	1121035.AUCH01000004_gene429	0.0	1199.0	COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria	1224|Proteobacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
CMS1_k127_5228207_1	941824.TCEL_00242	1.122e-121	410.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,36E7M@31979|Clostridiaceae	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
CMS1_k127_5228207_6	204536.SULAZ_0121	5.733e-36	138.0	COG3118@1|root,COG3118@2|Bacteria,2G453@200783|Aquificae	200783|Aquificae	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
CMS1_k127_5228207_0	237368.SCABRO_01504	1.004e-122	410.0	COG0659@1|root,COG0659@2|Bacteria,2IX8K@203682|Planctomycetes	203682|Planctomycetes	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	-
CMS1_k127_5228207_3	349741.Amuc_0029	1.252e-75	265.0	COG0451@1|root,COG0451@2|Bacteria,46UCR@74201|Verrucomicrobia,2IWKH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	NmrA-like family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
CMS1_k127_5228207_5	1480694.DC28_11645	5.837e-47	180.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS1_k127_5228207_4	526222.Desal_2683	1.082e-47	188.0	COG4267@1|root,COG4267@2|Bacteria,1MUQN@1224|Proteobacteria,42Q3G@68525|delta/epsilon subdivisions,2WKR6@28221|Deltaproteobacteria,2MAM4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative exopolysaccharide Exporter (EPS-E)	-	-	-	ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	PelG
CMS1_k127_5228207_2	1121451.DESAM_21835	1.073e-100	345.0	COG0438@1|root,COG0438@2|Bacteria,1MVEG@1224|Proteobacteria,42Q1K@68525|delta/epsilon subdivisions,2WJ1U@28221|Deltaproteobacteria,2M8XU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Domain of unknown function (DUF3492)	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glycos_transf_1
CMS1_k127_5228207_7	1265503.KB905171_gene601	1.244e-05	57.0	COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,2Q80C@267889|Colwelliaceae	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
CMS1_k127_5228634_4	580331.Thit_1844	3.702e-21	93.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1V2NQ@1239|Firmicutes,25KP2@186801|Clostridia,42I7M@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS1_k127_5228634_2	290315.Clim_0976	1.357e-60	222.0	COG1477@1|root,COG1477@2|Bacteria,1FDAW@1090|Chlorobi	1090|Chlorobi	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
CMS1_k127_5228634_3	1229520.ADIAL_1352	6.56e-22	104.0	COG0546@1|root,COG0546@2|Bacteria,1V6BF@1239|Firmicutes,4IPWM@91061|Bacilli,27HAE@186828|Carnobacteriaceae	91061|Bacilli	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
CMS1_k127_5228634_0	945713.IALB_1617	3.993e-100	334.0	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.98.1	ko:K00226,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15540	DHO_dh
CMS1_k127_5228634_1	247490.KSU1_C0302	1.074e-75	264.0	COG0079@1|root,COG0079@2|Bacteria,2IWYA@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
CMS1_k127_5231436_0	634176.NT05HA_1692	4.679e-176	558.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,1Y704@135625|Pasteurellales	135625|Pasteurellales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS1_k127_5231436_2	545694.TREPR_0296	1.731e-30	131.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
CMS1_k127_5231436_1	641491.DND132_1073	7.421e-104	356.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2M8JP@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,sCache_2
CMS1_k127_5240083_1	332101.JIBU02000008_gene554	1.105e-51	190.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,36EH8@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_5240083_2	639282.DEFDS_0170	2.997e-46	176.0	COG3769@1|root,COG3769@2|Bacteria,2GGFI@200930|Deferribacteres	200930|Deferribacteres	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.70	ko:K07026	ko00051,map00051	-	R05790	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
CMS1_k127_5240083_0	1123274.KB899421_gene1813	6.205e-58	212.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
CMS1_k127_527063_3	1167006.UWK_00694	5.552e-26	111.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
CMS1_k127_527063_2	234267.Acid_2217	1.725e-34	143.0	COG0705@1|root,COG0705@2|Bacteria,3Y45U@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS1_k127_527063_0	880073.Calab_2574	0.0	1303.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
CMS1_k127_527063_1	1307761.L21SP2_0548	4.481e-41	156.0	COG0366@1|root,COG0366@2|Bacteria,2J9X3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_5273153_0	436114.SYO3AOP1_1549	2.919e-08	59.0	COG3746@1|root,COG3746@2|Bacteria,2G4NR@200783|Aquificae	200783|Aquificae	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5273153_2	1173023.KE650771_gene5291	9.995e-05	54.0	COG4675@1|root,COG4675@2|Bacteria	2|Bacteria	M	tail collar domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Collar,DUF859
CMS1_k127_5273153_1	1403313.AXBR01000004_gene1605	2.729e-07	63.0	COG4675@1|root,COG4675@2|Bacteria,1VH1P@1239|Firmicutes	1239|Firmicutes	S	tail collar domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5321713_3	537011.PREVCOP_04480	1.517e-35	141.0	COG0115@1|root,COG0115@2|Bacteria,4NSFJ@976|Bacteroidetes,2FNQJ@200643|Bacteroidia	976|Bacteroidetes	EH	Psort location Cytoplasmic, score 8.96	-	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
CMS1_k127_5321713_0	398512.JQKC01000026_gene3790	4.453e-110	364.0	COG0147@1|root,COG0147@2|Bacteria,1UYHH@1239|Firmicutes,24BZ1@186801|Clostridia,3WNDH@541000|Ruminococcaceae	186801|Clostridia	EH	chorismate binding enzyme	-	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Chorismate_bind
CMS1_k127_5321713_2	1480694.DC28_10570	1.093e-42	168.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
CMS1_k127_5321713_1	1292035.H476_2576	2.396e-55	209.0	COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia	186801|Clostridia	T	Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	GAF_2,HD,HD_5
CMS1_k127_5323254_1	573413.Spirs_1762	2.791e-29	126.0	COG0845@1|root,COG0845@2|Bacteria,2J7T7@203691|Spirochaetes	203691|Spirochaetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
CMS1_k127_5323254_0	572479.Hprae_1819	1.978e-54	201.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,3WAEE@53433|Halanaerobiales	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	nolG	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
CMS1_k127_5328542_1	1242864.D187_008156	5.264e-49	183.0	COG4676@1|root,COG4676@2|Bacteria,1R801@1224|Proteobacteria	1224|Proteobacteria	S	Signal peptide protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2135,VIT
CMS1_k127_5328542_0	1242864.D187_008157	9.279e-143	505.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,42MJ8@68525|delta/epsilon subdivisions,2X2JP@28221|Deltaproteobacteria,2YY11@29|Myxococcales	28221|Deltaproteobacteria	S	A-macroglobulin complement component	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
CMS1_k127_5340824_0	394503.Ccel_0862	5.451e-85	304.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,24YJI@186801|Clostridia,36UKQ@31979|Clostridiaceae	186801|Clostridia	Q	Beta-ketoacyl synthase	-	-	-	ko:K13612	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS1_k127_5343707_0	521045.Kole_0459	9.061e-100	339.0	COG0477@1|root,COG2814@2|Bacteria,2GC8X@200918|Thermotogae	200918|Thermotogae	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
CMS1_k127_5343707_2	1454202.PPBDW_90718___1	3.867e-55	203.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1XSMN@135623|Vibrionales	135623|Vibrionales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
CMS1_k127_5343707_1	926561.KB900617_gene1518	2.442e-55	200.0	COG3437@1|root,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,25E5I@186801|Clostridia,3WCBF@53433|Halanaerobiales	186801|Clostridia	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5
CMS1_k127_5343707_3	1121904.ARBP01000009_gene4257	1.865e-09	59.0	2DI4K@1|root,3020V@2|Bacteria,4NV1J@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
CMS1_k127_5349294_1	443144.GM21_3268	8.518e-25	105.0	COG3530@1|root,COG3530@2|Bacteria,1N7GT@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	ypeB	-	-	ko:K09954	-	-	-	-	ko00000	-	-	-	QSregVF_b
CMS1_k127_5349294_2	1458357.BG58_19185	6.354e-07	60.0	COG4254@1|root,COG4254@2|Bacteria,1NBPR@1224|Proteobacteria,2VWWI@28216|Betaproteobacteria,1K9BB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
CMS1_k127_5349294_0	1280390.CBQR020000078_gene1703	7.864e-122	398.0	COG2746@1|root,COG2746@2|Bacteria,1V2QD@1239|Firmicutes,4HC3S@91061|Bacilli,26TRK@186822|Paenibacillaceae	91061|Bacilli	V	Aminoglycoside 3-N-acetyltransferase	-	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
CMS1_k127_5358845_0	1227268.HMPREF1552_01738	6.74e-276	859.0	COG1217@1|root,COG1217@2|Bacteria,378B5@32066|Fusobacteria	32066|Fusobacteria	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
CMS1_k127_5358845_2	1122179.KB890491_gene4510	2.333e-09	66.0	2DVXR@1|root,33XM1@2|Bacteria,4P3CX@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
CMS1_k127_5358845_1	211165.AJLN01000066_gene4475	6.28e-75	260.0	COG0561@1|root,COG0561@2|Bacteria,1GDI4@1117|Cyanobacteria	1117|Cyanobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
CMS1_k127_540008_0	86416.Clopa_3943	6.502e-164	533.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,36EQD@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.133,3.2.1.135,3.2.1.54	ko:K01208	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_N,Malt_amylase_C
CMS1_k127_540008_3	1511.CLOST_2079	5.331e-36	153.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,25S47@186804|Peptostreptococcaceae	186801|Clostridia	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_540008_2	1304885.AUEY01000011_gene1774	2.56e-59	220.0	COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,42Q2E@68525|delta/epsilon subdivisions,2WK17@28221|Deltaproteobacteria,2MMNU@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Inner membrane protein CreD	-	-	-	ko:K06143	-	-	-	-	ko00000	-	-	-	CreD
CMS1_k127_540008_1	443143.GM18_3985	2.229e-59	215.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,42PMH@68525|delta/epsilon subdivisions,2WKZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07641,ko:K14980	ko02020,map02020	M00449,M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,dCache_3
CMS1_k127_5414874_4	96561.Dole_1511	2.879e-24	112.0	COG1597@1|root,COG1597@2|Bacteria,1PV0P@1224|Proteobacteria,42XZR@68525|delta/epsilon subdivisions,2WTF1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM diacylglycerol kinase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
CMS1_k127_5414874_2	1540257.JQMW01000013_gene988	4.69e-50	184.0	COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,36FWE@31979|Clostridiaceae	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
CMS1_k127_5414874_0	158190.SpiGrapes_2243	2.216e-135	446.0	COG0469@1|root,COG0469@2|Bacteria,2J5VE@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
CMS1_k127_5414874_1	1307761.L21SP2_3042	2.069e-55	204.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
CMS1_k127_5414874_3	665571.STHERM_c06950	2.184e-45	169.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding,DUF2442
CMS1_k127_5422560_1	694427.Palpr_2945	1.498e-30	132.0	2DC1B@1|root,2ZCDD@2|Bacteria,4NRQJ@976|Bacteroidetes,2FT3K@200643|Bacteroidia,22Y5M@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5422560_0	377629.TERTU_4398	1.224e-72	269.0	COG0604@1|root,COG1028@1|root,COG3321@1|root,COG0604@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,1SMTI@1236|Gammaproteobacteria,2PP7Q@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	Q	PKS_DH	pltB	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
CMS1_k127_5463548_2	1123399.AQVE01000014_gene67	8.008e-32	136.0	COG4872@1|root,COG4872@2|Bacteria,1N4JN@1224|Proteobacteria	1224|Proteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
CMS1_k127_5463548_1	1289135.A966_07010	1.839e-111	374.0	COG0141@1|root,COG0141@2|Bacteria,2J5QF@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
CMS1_k127_5463548_0	1121405.dsmv_0667	8.986e-125	414.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,42PST@68525|delta/epsilon subdivisions,2WJ3A@28221|Deltaproteobacteria,2MIS5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
CMS1_k127_5468121_0	402880.MmarC5_0678	4.674e-77	268.0	COG1052@1|root,arCOG01755@2157|Archaea,2Y84H@28890|Euryarchaeota,23RW0@183939|Methanococci	183939|Methanococci	C	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS1_k127_5468121_2	1121104.AQXH01000001_gene1642	2.119e-48	182.0	COG0584@1|root,COG0584@2|Bacteria,4NGNU@976|Bacteroidetes	976|Bacteroidetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
CMS1_k127_5468121_1	889378.Spiaf_0365	8.854e-74	257.0	2EYA0@1|root,33RIG@2|Bacteria,2J6Q4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5468288_1	247490.KSU1_C0421	4.887e-22	108.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS1_k127_5468288_0	1047013.AQSP01000140_gene2513	1.787e-39	161.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
CMS1_k127_5468288_2	63737.Npun_F3370	8.183e-07	57.0	COG1520@1|root,COG2931@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,1G342@1117|Cyanobacteria,1HMWZ@1161|Nostocales	1117|Cyanobacteria	M	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP
CMS1_k127_5469080_0	926561.KB900617_gene1905	3.993e-212	679.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,Big_2,CBM_20,CBM_48,PUD
CMS1_k127_5499154_1	314230.DSM3645_16200	7.607e-14	81.0	COG1305@1|root,COG1305@2|Bacteria,2IYTT@203682|Planctomycetes	203682|Planctomycetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS1_k127_5499154_0	889378.Spiaf_1197	4.635e-50	190.0	COG0042@1|root,COG0042@2|Bacteria,2J59K@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
CMS1_k127_5523712_0	1280671.AUJH01000002_gene1550	8.562e-112	366.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,4BWR2@830|Butyrivibrio	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
CMS1_k127_5523712_2	381764.Fnod_0316	1.131e-63	231.0	COG0142@1|root,COG0142@2|Bacteria,2GD2F@200918|Thermotogae	200918|Thermotogae	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
CMS1_k127_5523712_1	1121447.JONL01000002_gene2170	9.332e-102	339.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2M8BZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM transferase hexapeptide repeat containing protein	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
CMS1_k127_5523712_3	865861.AZSU01000002_gene2488	1.626e-42	170.0	COG5438@1|root,COG5438@2|Bacteria,1TPEV@1239|Firmicutes,249SW@186801|Clostridia,36GKC@31979|Clostridiaceae	186801|Clostridia	S	YibE F family protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
CMS1_k127_5569210_0	517418.Ctha_0544	1.735e-197	628.0	COG0449@1|root,COG0449@2|Bacteria,1FDCR@1090|Chlorobi	1090|Chlorobi	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
CMS1_k127_5571547_0	381764.Fnod_0026	2.588e-34	144.0	COG1306@1|root,COG1306@2|Bacteria	2|Bacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
CMS1_k127_5584592_4	189425.PGRAT_26210	5.44e-33	137.0	COG3568@1|root,COG3568@2|Bacteria,1VJAZ@1239|Firmicutes,4I6R0@91061|Bacilli,26UDK@186822|Paenibacillaceae	91061|Bacilli	S	Carbohydrate/starch-binding module (family 21)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_21
CMS1_k127_5584592_2	398767.Glov_2353	7.986e-41	162.0	COG0705@1|root,COG0705@2|Bacteria,1N258@1224|Proteobacteria,42UB4@68525|delta/epsilon subdivisions,2WQJ3@28221|Deltaproteobacteria,43W1K@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS1_k127_5584592_3	443254.Marpi_1571	1.413e-37	150.0	COG0363@1|root,COG0363@2|Bacteria,2GD72@200918|Thermotogae	200918|Thermotogae	G	6-phosphogluconolactonase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1154	Glucosamine_iso
CMS1_k127_5584592_0	439235.Dalk_3007	9.504e-152	496.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2MMYN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
CMS1_k127_5584592_1	765420.OSCT_1272	1.026e-111	368.0	COG1023@1|root,COG1023@2|Bacteria,2G5YD@200795|Chloroflexi,375RD@32061|Chloroflexia	32061|Chloroflexia	G	TIGRFAM 6-phosphogluconate dehydrogenase, decarboxylating	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
CMS1_k127_5589391_3	326298.Suden_1933	2.625e-39	156.0	COG4121@1|root,COG4121@2|Bacteria,1Q8T8@1224|Proteobacteria,42RAP@68525|delta/epsilon subdivisions,2YP3B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_30
CMS1_k127_5589391_4	1191523.MROS_0616	3.781e-24	106.0	COG2703@1|root,COG2703@2|Bacteria	2|Bacteria	P	oxygen carrier activity	-	-	-	ko:K03406,ko:K07216	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Hemerythrin,MCPsignal,PilJ
CMS1_k127_5589391_1	1089553.Tph_c22340	5.038e-78	269.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,42GGT@68295|Thermoanaerobacterales	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
CMS1_k127_5589391_6	331678.Cphamn1_2066	4.866e-13	72.0	COG1872@1|root,COG1872@2|Bacteria,1FE84@1090|Chlorobi	1090|Chlorobi	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
CMS1_k127_5589391_2	888062.HMPREF9083_0111	1.843e-47	177.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,4H2ZU@909932|Negativicutes	909932|Negativicutes	S	domain protein	gloB	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
CMS1_k127_5589391_5	497964.CfE428DRAFT_4578	4.577e-22	101.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN3	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
CMS1_k127_5589391_0	289376.THEYE_A0876	3.205e-120	395.0	COG2255@1|root,COG2255@2|Bacteria,3J0AU@40117|Nitrospirae	40117|Nitrospirae	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
CMS1_k127_5595855_0	247490.KSU1_D1033	1.826e-211	670.0	COG0028@1|root,COG0028@2|Bacteria,2IXMU@203682|Planctomycetes	203682|Planctomycetes	H	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS1_k127_5595855_3	1195236.CTER_4338	1.524e-42	162.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,3WJ0F@541000|Ruminococcaceae	186801|Clostridia	E	Acetolactate synthase small	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
CMS1_k127_5595855_2	391612.CY0110_27054	1.033e-65	231.0	COG4122@1|root,COG4122@2|Bacteria,1G2Y6@1117|Cyanobacteria,3KGRF@43988|Cyanothece	1117|Cyanobacteria	H	PFAM O-methyltransferase family 3	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
CMS1_k127_5595855_1	1123371.ATXH01000021_gene1117	1.078e-67	236.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
CMS1_k127_5599038_1	1237149.C900_03460	1.38e-89	300.0	COG1354@1|root,COG1354@2|Bacteria,4NJQE@976|Bacteroidetes,47MUR@768503|Cytophagia	976|Bacteroidetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
CMS1_k127_5599038_0	1237149.C900_03461	1.093e-112	374.0	COG0392@1|root,COG0392@2|Bacteria,4NIWG@976|Bacteroidetes,47MPB@768503|Cytophagia	976|Bacteroidetes	S	PFAM Uncharacterised protein family (UPF0104)	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
CMS1_k127_5599038_2	926556.Echvi_1762	1.558e-49	183.0	COG0237@1|root,COG0237@2|Bacteria,4NQKS@976|Bacteroidetes,47P6S@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
CMS1_k127_5601502_0	1403819.BATR01000114_gene3909	4.397e-211	676.0	COG2304@1|root,COG2304@2|Bacteria,46XD8@74201|Verrucomicrobia,2IVI0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT
CMS1_k127_5601502_1	907348.TresaDRAFT_1929	2.27e-99	349.0	COG0366@1|root,COG0366@2|Bacteria,2J9X3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_5601502_2	1094508.Tsac_2156	1.554e-12	75.0	COG0664@1|root,COG0664@2|Bacteria,1V5MZ@1239|Firmicutes,24AQS@186801|Clostridia,42JF4@68295|Thermoanaerobacterales	186801|Clostridia	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914,ko:K21562	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_560300_0	574087.Acear_0683	2.314e-154	511.0	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,3WADB@53433|Halanaerobiales	186801|Clostridia	J	glycyl-tRNA synthetase, tetrameric type, beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
CMS1_k127_560300_2	1499967.BAYZ01000068_gene1980	1.433e-23	102.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS1_k127_560300_1	1304875.JAFZ01000001_gene1334	2.026e-51	196.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,3T9T4@508458|Synergistetes	508458|Synergistetes	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
CMS1_k127_560300_3	1480694.DC28_03075	5.126e-06	52.0	COG1664@1|root,COG1664@2|Bacteria,2J85N@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
CMS1_k127_5627193_6	1348114.OM33_13615	0.0001368	47.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1RSHC@1236|Gammaproteobacteria,2Q1ZX@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid,zf-TFIIB
CMS1_k127_5627193_1	269799.Gmet_3529	1.258e-61	229.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42T4H@68525|delta/epsilon subdivisions,2WPIT@28221|Deltaproteobacteria,43U0U@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS1_k127_5627193_0	858215.Thexy_1508	1.414e-83	293.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,42F4H@68295|Thermoanaerobacterales	186801|Clostridia	J	SMART Elongator protein 3 MiaB NifB	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
CMS1_k127_5627193_4	1123276.KB893311_gene3127	3.986e-28	123.0	COG0558@1|root,COG0558@2|Bacteria,4NGNI@976|Bacteroidetes,47XVV@768503|Cytophagia	976|Bacteroidetes	I	CDP-alcohol phosphatidyltransferase	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
CMS1_k127_5627193_3	933262.AXAM01000005_gene2466	8.476e-57	205.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2MJ9P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
CMS1_k127_5627193_2	1301100.HG529332_gene4568	1.69e-60	218.0	COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,247SR@186801|Clostridia,36E5T@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
CMS1_k127_5627193_5	1121289.JHVL01000038_gene2996	2.1e-19	98.0	COG0739@1|root,COG3583@1|root,COG0739@2|Bacteria,COG3583@2|Bacteria,1TRWJ@1239|Firmicutes,24A2J@186801|Clostridia,36HF8@31979|Clostridiaceae	186801|Clostridia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	G5,LysM,Peptidase_M23
CMS1_k127_5630674_3	1410653.JHVC01000005_gene2497	5.1e-18	96.0	COG0834@1|root,COG5000@1|root,COG0834@2|Bacteria,COG5000@2|Bacteria,1TSVK@1239|Firmicutes,24CCA@186801|Clostridia,36HB1@31979|Clostridiaceae	186801|Clostridia	T	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	HATPase_c,HisKA,PAS_9,SBP_bac_3
CMS1_k127_5630674_1	1121405.dsmv_2220	8.856e-75	262.0	COG0042@1|root,COG0042@2|Bacteria,1QDJE@1224|Proteobacteria,42PCR@68525|delta/epsilon subdivisions,2WKBH@28221|Deltaproteobacteria,2MJ5C@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
CMS1_k127_5630674_2	1408439.JHXW01000004_gene1286	9.038e-61	225.0	COG2067@1|root,COG2067@2|Bacteria,37BVP@32066|Fusobacteria	32066|Fusobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	-	-	-	-	-	-	-	-	-	Toluene_X
CMS1_k127_5630674_0	1304885.AUEY01000009_gene1927	2.42e-141	475.0	COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria,2MHMP@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,Hydrolase_4
CMS1_k127_5630674_4	1410609.JHVB01000003_gene368	1.14e-12	74.0	COG2208@1|root,COG2208@2|Bacteria,2J5UP@203691|Spirochaetes	203691|Spirochaetes	KT	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,SpoIIE
CMS1_k127_5639946_0	526224.Bmur_2739	6.09e-174	556.0	COG1061@1|root,COG1061@2|Bacteria,2J6EB@203691|Spirochaetes	203691|Spirochaetes	L	DNA or RNA helicase of superfamily II	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
CMS1_k127_5639946_3	243275.TDE_2182	9.466e-71	262.0	COG1306@1|root,COG1306@2|Bacteria,2J5BQ@203691|Spirochaetes	203691|Spirochaetes	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
CMS1_k127_5639946_2	545694.TREPR_0296	1.581e-106	352.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
CMS1_k127_5639946_1	573413.Spirs_2597	2.823e-108	358.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
CMS1_k127_5647961_0	1121440.AUMA01000007_gene1062	5.234e-171	548.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2M80K@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
CMS1_k127_5647961_1	517417.Cpar_1226	1.711e-45	166.0	COG0347@1|root,COG0347@2|Bacteria,1FE1X@1090|Chlorobi	1090|Chlorobi	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
CMS1_k127_5647961_2	1123059.KB823014_gene36	1.676e-06	59.0	29A93@1|root,33K0N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
CMS1_k127_5651944_2	204536.SULAZ_0665	1.363e-05	56.0	COG2885@1|root,COG2885@2|Bacteria,2G559@200783|Aquificae	200783|Aquificae	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
CMS1_k127_5651944_0	1480694.DC28_10570	9.542e-40	160.0	COG2208@1|root,COG2208@2|Bacteria,2J88B@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
CMS1_k127_5651944_1	189425.PGRAT_26210	8.574e-30	128.0	COG3568@1|root,COG3568@2|Bacteria,1VJAZ@1239|Firmicutes,4I6R0@91061|Bacilli,26UDK@186822|Paenibacillaceae	91061|Bacilli	S	Carbohydrate/starch-binding module (family 21)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_21
CMS1_k127_5654994_6	880073.Calab_0077	3.237e-17	89.0	COG0558@1|root,COG0558@2|Bacteria,2NQ32@2323|unclassified Bacteria	2|Bacteria	I	CDP-alcohol phosphatidyltransferase	pgsA	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS1_k127_5654994_2	459349.CLOAM1516	4.925e-42	169.0	COG0860@1|root,COG0860@2|Bacteria,2NPCZ@2323|unclassified Bacteria	2|Bacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
CMS1_k127_5654994_0	247490.KSU1_B0500	1.045e-105	349.0	COG0253@1|root,COG0253@2|Bacteria,2IYCH@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
CMS1_k127_5654994_5	332101.JIBU02000058_gene2584	2.641e-31	134.0	COG0726@1|root,COG0726@2|Bacteria,1V6AW@1239|Firmicutes,24EU8@186801|Clostridia,36EYC@31979|Clostridiaceae	186801|Clostridia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
CMS1_k127_5654994_1	1307761.L21SP2_1654	1.181e-50	194.0	28QN2@1|root,2ZD3Q@2|Bacteria,2JBB4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans
CMS1_k127_5654994_3	926561.KB900617_gene2194	4.283e-36	147.0	COG0739@1|root,COG0739@2|Bacteria,1VAC5@1239|Firmicutes,25EMF@186801|Clostridia,3WAQ2@53433|Halanaerobiales	186801|Clostridia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	LysM,PG_binding_1,Peptidase_M23
CMS1_k127_5664031_0	1173027.Mic7113_5584	3.827e-48	179.0	COG1434@1|root,COG1434@2|Bacteria,1GBDS@1117|Cyanobacteria	1117|Cyanobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
CMS1_k127_5664031_1	1304284.L21TH_1055	1.511e-13	74.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,36I28@31979|Clostridiaceae	186801|Clostridia	L	RNA methyltransferase, RsmD family	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
CMS1_k127_5685714_0	933262.AXAM01000014_gene256	3.733e-279	880.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
CMS1_k127_5685714_2	243232.MJ_1065	1.723e-67	243.0	COG2089@1|root,arCOG01050@2157|Archaea,2XTT7@28890|Euryarchaeota,23Q74@183939|Methanococci	183939|Methanococci	H	SAF	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
CMS1_k127_5685714_3	1211817.CCAT010000073_gene1023	6.736e-08	56.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,36DG2@31979|Clostridiaceae	186801|Clostridia	NU	type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
CMS1_k127_5685714_1	1031288.AXAA01000015_gene286	1.726e-159	508.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia,36E7V@31979|Clostridiaceae	186801|Clostridia	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
CMS1_k127_5704506_0	287.DR97_1698	1.625e-147	473.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria,1YD8X@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Belongs to the Orn Lys Arg decarboxylase class-II family	speC	-	4.1.1.17,4.1.1.20	ko:K01581,ko:K01586	ko00300,ko00330,ko00480,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map00330,map00480,map01100,map01110,map01120,map01130,map01230	M00016,M00134,M00525,M00526,M00527	R00451,R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0864	Orn_Arg_deC_N,Orn_DAP_Arg_deC
CMS1_k127_5704506_1	755178.Cyan10605_2980	9.285e-10	67.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	4.6.1.1	ko:K01768,ko:K19694	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,dCache_1
CMS1_k127_5705294_0	1536769.P40081_15490	5.326e-55	201.0	COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,4HDUN@91061|Bacilli,26T4Z@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
CMS1_k127_5705294_1	523845.AQXV01000009_gene243	9.754e-13	74.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,23R23@183939|Methanococci	183939|Methanococci	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
CMS1_k127_5716111_1	526222.Desal_2683	1.166e-60	220.0	COG4267@1|root,COG4267@2|Bacteria,1MUQN@1224|Proteobacteria,42Q3G@68525|delta/epsilon subdivisions,2WKR6@28221|Deltaproteobacteria,2MAM4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative exopolysaccharide Exporter (EPS-E)	-	-	-	ko:K21012	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	PelG
CMS1_k127_5716111_0	1121447.JONL01000009_gene2651	1.941e-98	339.0	COG0438@1|root,COG0438@2|Bacteria,1MVEG@1224|Proteobacteria,42Q1K@68525|delta/epsilon subdivisions,2WJ1U@28221|Deltaproteobacteria,2M8XU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Domain of unknown function (DUF3492)	-	-	-	ko:K21011	ko02025,map02025	-	-	-	ko00000,ko00001,ko01003	-	GT4	-	DUF3492,Glycos_transf_1
CMS1_k127_5716111_2	96561.Dole_0881	7.132e-56	215.0	COG2204@1|root,COG3437@1|root,COG5002@1|root,COG2204@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1MUB8@1224|Proteobacteria,42NWQ@68525|delta/epsilon subdivisions,2WM5R@28221|Deltaproteobacteria,2MJ8Y@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD_5,PAS,PAS_4
CMS1_k127_5716111_3	1379698.RBG1_1C00001G1850	2.591e-50	190.0	COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria	2|Bacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
CMS1_k127_571696_2	573063.Metin_0813	3.297e-08	67.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,23Q3I@183939|Methanococci	183939|Methanococci	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,Rad50_zn_hook
CMS1_k127_571696_1	1123274.KB899421_gene1772	3.635e-32	138.0	COG0457@1|root,COG0457@2|Bacteria,2J7GS@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
CMS1_k127_571696_0	1232410.KI421413_gene926	0.0	1096.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,43S3P@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Valyl tRNA synthetase tRNA binding arm	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
CMS1_k127_571696_3	679199.HMPREF9332_01744	2.691e-06	59.0	COG0577@1|root,COG0577@2|Bacteria,4NGDV@976|Bacteroidetes,2FP9P@200643|Bacteroidia	976|Bacteroidetes	V	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5723434_1	1121930.AQXG01000004_gene2925	9.492e-44	175.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_4
CMS1_k127_5723434_0	1410653.JHVC01000002_gene4476	2.181e-235	738.0	COG0488@1|root,COG0488@2|Bacteria,1TPW0@1239|Firmicutes,248ST@186801|Clostridia,36E0B@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	ykpA	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
CMS1_k127_5726802_20	158190.SpiGrapes_2092	1.447e-22	99.0	COG1143@1|root,COG1941@1|root,COG4624@1|root,COG1143@2|Bacteria,COG1941@2|Bacteria,COG4624@2|Bacteria,2J6BD@203691|Spirochaetes	203691|Spirochaetes	C	Fe-hydrogenase large subunit family protein	-	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_lg_C,Fer4
CMS1_k127_5726802_23	906968.Trebr_2314	2.782e-13	72.0	COG1905@1|root,COG1905@2|Bacteria,2J9F5@203691|Spirochaetes	203691|Spirochaetes	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS1_k127_5726802_4	573413.Spirs_1302	2.915e-130	427.0	COG2208@1|root,COG2208@2|Bacteria,2J6CG@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
CMS1_k127_5726802_2	158190.SpiGrapes_2089	1.838e-149	492.0	COG1145@1|root,COG4624@1|root,COG1145@2|Bacteria,COG4624@2|Bacteria,2J73J@203691|Spirochaetes	203691|Spirochaetes	C	PAS PAC sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,PAS_8
CMS1_k127_5726802_21	880073.Calab_2675	4.258e-22	97.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
CMS1_k127_5726802_0	926561.KB900617_gene1315	0.0	1266.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,3WAGG@53433|Halanaerobiales	186801|Clostridia	C	belongs to the iron- containing alcohol dehydrogenase family	adhE	-	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
CMS1_k127_5726802_11	526224.Bmur_1396	4.094e-57	205.0	COG2344@1|root,COG2344@2|Bacteria,2J89C@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
CMS1_k127_5726802_10	509191.AEDB02000085_gene2690	3.333e-59	216.0	COG1075@1|root,COG1075@2|Bacteria,1TQFF@1239|Firmicutes,2494B@186801|Clostridia,3WHQJ@541000|Ruminococcaceae	186801|Clostridia	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF676,PGAP1
CMS1_k127_5726802_5	1304885.AUEY01000037_gene2207	2.789e-117	387.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria,2MIY1@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
CMS1_k127_5726802_7	1304885.AUEY01000037_gene2208	5.103e-113	373.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2MI94@213118|Desulfobacterales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
CMS1_k127_5726802_16	545695.TREAZ_2641	1.444e-42	168.0	COG2199@1|root,COG2199@2|Bacteria,2JBGC@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
CMS1_k127_5726802_13	754027.HMPREF9554_00730	5.621e-51	193.0	COG2199@1|root,COG3706@2|Bacteria,2J5S2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,cNMP_binding
CMS1_k127_5726802_17	1158345.JNLL01000001_gene1349	2.372e-40	152.0	COG0251@1|root,COG0251@2|Bacteria,2G53U@200783|Aquificae	200783|Aquificae	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
CMS1_k127_5726802_6	635013.TherJR_0016	6.092e-117	384.0	COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,248J4@186801|Clostridia,260HJ@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
CMS1_k127_5726802_3	1265505.ATUG01000001_gene4670	3.841e-133	433.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria,2MHP9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
CMS1_k127_5726802_15	706587.Desti_2376	6.312e-46	174.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glycyl-radical enzyme activating protein family	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
CMS1_k127_5726802_1	706587.Desti_2378	7.832e-186	608.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	Gly_radical,PFL-like
CMS1_k127_5726802_12	439235.Dalk_4973	3.209e-52	200.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	-	-	3.1.1.53	ko:K03547,ko:K05970	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Metallophos,Metallophos_2
CMS1_k127_5726802_9	573413.Spirs_0764	2.85e-66	235.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	-	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
CMS1_k127_5726802_14	717605.Theco_1139	2.762e-46	173.0	COG0352@1|root,COG2104@1|root,COG0352@2|Bacteria,COG2104@2|Bacteria,1V3ZR@1239|Firmicutes,4HH1E@91061|Bacilli,26UCZ@186822|Paenibacillaceae	91061|Bacilli	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
CMS1_k127_5726802_25	1450694.BTS2_3168	7.462e-13	70.0	COG2104@1|root,COG2104@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	iJN678.ycf40	ThiS
CMS1_k127_5726802_19	1295642.H839_11204	1.882e-33	134.0	COG0454@1|root,COG0456@2|Bacteria,1V5T6@1239|Firmicutes,4HHXQ@91061|Bacilli	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_5726802_22	158189.SpiBuddy_1561	1.509e-20	102.0	COG1357@1|root,COG5279@1|root,COG1357@2|Bacteria,COG5279@2|Bacteria	2|Bacteria	D	protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
CMS1_k127_5726802_26	1123008.KB905701_gene2210	2.245e-11	74.0	COG0823@1|root,COG5337@1|root,COG0823@2|Bacteria,COG5337@2|Bacteria,4PKX1@976|Bacteroidetes,2FRVN@200643|Bacteroidia,22Y8I@171551|Porphyromonadaceae	976|Bacteroidetes	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	BACON,CotH
CMS1_k127_5726802_8	96561.Dole_2293	6.884e-82	280.0	COG3527@1|root,COG3527@2|Bacteria,1MWDZ@1224|Proteobacteria,42R9C@68525|delta/epsilon subdivisions,2WN1P@28221|Deltaproteobacteria,2MJJP@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
CMS1_k127_5726802_18	439235.Dalk_0029	1.796e-34	147.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
CMS1_k127_5728526_9	526224.Bmur_1345	0.000931	53.0	COG0457@1|root,COG0457@2|Bacteria,2J5I5@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
CMS1_k127_5728526_6	1031288.AXAA01000006_gene1106	8.761e-18	92.0	COG0296@1|root,COG0366@1|root,COG0296@2|Bacteria,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,36EQD@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Alpha-amylase,Alpha-amylase_N,Big_2,CBM_20,CBM_48,Cadherin-like,Malt_amylase_C,PUD,SLH
CMS1_k127_5728526_2	935948.KE386494_gene194	6.366e-42	159.0	COG1522@1|root,COG1522@2|Bacteria,1V3PB@1239|Firmicutes,24I3N@186801|Clostridia,42G0Y@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM Transcription regulator	Lrp	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
CMS1_k127_5728526_4	456442.Mboo_0639	8.086e-28	123.0	COG3741@1|root,arCOG08266@2157|Archaea	2157|Archaea	E	N-formylglutamate amidohydrolase	-	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
CMS1_k127_5728526_0	667014.Thein_1152	4.756e-90	306.0	COG0492@1|root,COG0492@2|Bacteria,2GHK3@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
CMS1_k127_5728526_7	889378.Spiaf_2521	8.963e-09	69.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	malS	-	2.1.1.72,3.1.4.46,3.2.1.1	ko:K00571,ko:K01126,ko:K01176	ko00500,ko00564,ko01100,ko04973,map00500,map00564,map01100,map04973	-	R01030,R01470,R02108,R02112,R11262	RC00017,RC00425	ko00000,ko00001,ko01000,ko02048	-	GH13	-	Alpha-amylase,CBM26
CMS1_k127_5728526_8	1457250.BBMO01000001_gene312	4.633e-05	57.0	COG0366@1|root,COG5520@1|root,arCOG02954@2157|Archaea,arCOG09138@2157|Archaea,2XTY8@28890|Euryarchaeota,23UPC@183963|Halobacteria	183963|Halobacteria	G	Domain of unknown function (DUF1939)	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF1939,RicinB_lectin_2
CMS1_k127_5728526_5	203124.Tery_1835	5.068e-27	129.0	COG0739@1|root,COG1566@1|root,COG1572@1|root,COG3391@1|root,COG4932@1|root,COG0739@2|Bacteria,COG1566@2|Bacteria,COG1572@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,1GPV0@1117|Cyanobacteria,1HFQY@1150|Oscillatoriales	2|Bacteria	M	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family	VPA1172	-	3.4.24.40	ko:K01406,ko:K13276,ko:K20276	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	DUF4114,DUF4842,OapA,Peptidase_M23
CMS1_k127_5728526_1	1230342.CTM_10366	4.431e-42	160.0	COG1051@1|root,COG1051@2|Bacteria,1VBB4@1239|Firmicutes,25H0C@186801|Clostridia	186801|Clostridia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS1_k127_5728526_3	913865.DOT_1227	5.207e-37	144.0	COG1765@1|root,COG1765@2|Bacteria,1V7SN@1239|Firmicutes,24SS3@186801|Clostridia	186801|Clostridia	O	redox protein, regulator of disulfide bond	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
CMS1_k127_5729673_1	493475.GARC_1271	2.045e-73	258.0	COG4286@1|root,COG4286@2|Bacteria,1MVTY@1224|Proteobacteria,1RYWZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	metal-dependent protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0160
CMS1_k127_5729673_0	1128398.Curi_c06120	4.939e-79	271.0	COG1385@1|root,COG1385@2|Bacteria	2|Bacteria	J	rRNA (uridine-N3-)-methyltransferase activity	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
CMS1_k127_5729673_2	269799.Gmet_0940	7.297e-55	195.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,43U0M@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
CMS1_k127_5732450_6	340099.Teth39_1071	8.928e-32	134.0	COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,24HC0@186801|Clostridia,42FQ9@68295|Thermoanaerobacterales	186801|Clostridia	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
CMS1_k127_5732450_4	1410653.JHVC01000019_gene2151	2.167e-103	347.0	COG0513@1|root,COG0513@2|Bacteria,1TQ9R@1239|Firmicutes,249Z4@186801|Clostridia,36DKG@31979|Clostridiaceae	186801|Clostridia	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
CMS1_k127_5732450_3	913865.DOT_3925	5.896e-111	364.0	COG0716@1|root,COG1145@1|root,COG0716@2|Bacteria,COG1145@2|Bacteria,1TSA0@1239|Firmicutes,24FJD@186801|Clostridia	186801|Clostridia	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
CMS1_k127_5732450_11	176280.SE_1607	0.0001616	46.0	COG2602@1|root,COG4219@1|root,COG2602@2|Bacteria,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,4HB9X@91061|Bacilli,4GX27@90964|Staphylococcaceae	91061|Bacilli	KTV	Regulatory protein BlaR1	blaR1-1	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	Peptidase_M56,Transpeptidase
CMS1_k127_5732450_7	517418.Ctha_1121	8.308e-26	108.0	COG2602@1|root,COG2602@2|Bacteria,1FE67@1090|Chlorobi	1090|Chlorobi	M	PFAM penicillin-binding protein transpeptidase	-	-	3.5.2.6	ko:K17838	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Transpeptidase
CMS1_k127_5732450_2	316067.Geob_1283	3.241e-122	435.0	COG1361@1|root,COG1404@1|root,COG3210@1|root,COG4625@1|root,COG4886@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,COG4886@2|Bacteria,1QUXB@1224|Proteobacteria	1224|Proteobacteria	U	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Cadherin_3,DUF11,DUF4347,He_PIG,PATR
CMS1_k127_5732450_0	398512.JQKC01000001_gene2166	6.363e-159	546.0	COG5184@1|root,COG5184@2|Bacteria,1TS5I@1239|Firmicutes,24A8Z@186801|Clostridia,3WRHH@541000|Ruminococcaceae	186801|Clostridia	DZ	Regulator of chromosome condensation (RCC1) repeat	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2,SLH
CMS1_k127_5732450_10	879212.DespoDRAFT_01235	0.0001282	46.0	COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,42NX3@68525|delta/epsilon subdivisions,2WME4@28221|Deltaproteobacteria,2MPJH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
CMS1_k127_5732450_5	1237149.C900_00626	2.596e-94	317.0	COG1708@1|root,COG1708@2|Bacteria,4NMIA@976|Bacteroidetes,47P7X@768503|Cytophagia	976|Bacteroidetes	S	Streptomycin adenylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Adenyl_transf
CMS1_k127_5732450_1	1499967.BAYZ01000088_gene5064	9.119e-136	445.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MatE
CMS1_k127_5732450_9	313595.P700755_000218	7.994e-09	61.0	COG1396@1|root,COG1396@2|Bacteria,4NHP0@976|Bacteroidetes,1HXUX@117743|Flavobacteriia	976|Bacteroidetes	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
CMS1_k127_5732450_8	931276.Cspa_c34360	5.106e-19	98.0	2E2F4@1|root,32XJH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5735260_3	1235798.C817_05836	7.525e-06	49.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,27V29@189330|Dorea	186801|Clostridia	P	COG COG3839 ABC-type sugar transport systems, ATPase components	ugpC_1	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
CMS1_k127_5735260_4	1528106.JRJE01000031_gene3215	0.0003244	48.0	2EIUW@1|root,33CK7@2|Bacteria,1NIXF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5735260_1	269799.Gmet_0117	8.078e-121	397.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,43U45@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
CMS1_k127_5735260_2	1379698.RBG1_1C00001G0044	9.141e-16	79.0	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653,ko:K04654	-	-	-	-	ko00000	-	-	-	HupF_HypC
CMS1_k127_5735260_0	1449126.JQKL01000002_gene1632	1.764e-154	508.0	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia	186801|Clostridia	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
CMS1_k127_5738399_2	880073.Calab_0277	1.088e-23	104.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	GSCFA
CMS1_k127_5738399_1	1499967.BAYZ01000001_gene5912	5.481e-48	181.0	28N2R@1|root,2ZB8J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2271,DUF4405
CMS1_k127_5738399_0	386415.NT01CX_1346	1.808e-157	507.0	COG1362@1|root,COG1362@2|Bacteria,1TQ3Z@1239|Firmicutes,248UP@186801|Clostridia,36EV0@31979|Clostridiaceae	186801|Clostridia	E	M18 family aminopeptidase	apeB	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
CMS1_k127_5738399_3	1046625.AFQY01000001_gene321	0.0005457	52.0	COG0457@1|root,COG4676@1|root,COG0457@2|Bacteria,COG4676@2|Bacteria,1R4D7@1224|Proteobacteria,1RZU4@1236|Gammaproteobacteria,3NKF1@468|Moraxellaceae	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_12,TPR_2,TPR_7,TPR_8
CMS1_k127_5750456_2	382464.ABSI01000011_gene2992	5.003e-71	244.0	COG0299@1|root,COG0299@2|Bacteria,46SS6@74201|Verrucomicrobia,2IU5Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_N
CMS1_k127_5750456_8	1121889.AUDM01000009_gene1215	0.0002644	53.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,1HX2D@117743|Flavobacteriia,2NTCP@237|Flavobacterium	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
CMS1_k127_5750456_1	1449126.JQKL01000012_gene3524	9.539e-82	278.0	COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,268H0@186813|unclassified Clostridiales	186801|Clostridia	K	Transcriptional regulator	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
CMS1_k127_5750456_3	316274.Haur_4753	1.121e-48	178.0	COG0817@1|root,COG0817@2|Bacteria,2G6MA@200795|Chloroflexi,375KP@32061|Chloroflexia	32061|Chloroflexia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
CMS1_k127_5750456_4	1120966.AUBU01000002_gene2125	4.4e-46	173.0	COG0349@1|root,COG0349@2|Bacteria,4NP3B@976|Bacteroidetes,47QFS@768503|Cytophagia	976|Bacteroidetes	J	3'-5' exonuclease	rnd	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_A_exo1
CMS1_k127_5750456_5	880073.Calab_2384	1.719e-36	153.0	COG2843@1|root,COG2843@2|Bacteria,2NPJI@2323|unclassified Bacteria	2|Bacteria	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
CMS1_k127_5750456_0	545695.TREAZ_2693	3.775e-138	455.0	COG0513@1|root,COG0513@2|Bacteria,2J5U7@203691|Spirochaetes	203691|Spirochaetes	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
CMS1_k127_5750456_7	293826.Amet_2131	9.002e-20	95.0	COG3153@1|root,COG3153@2|Bacteria,1VVRU@1239|Firmicutes,24M6C@186801|Clostridia,36K1C@31979|Clostridiaceae	186801|Clostridia	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_5750456_6	891968.Anamo_2052	2.223e-35	147.0	COG1489@1|root,COG1833@1|root,COG1489@2|Bacteria,COG1833@2|Bacteria,3TB3T@508458|Synergistetes	508458|Synergistetes	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	DUF123,SfsA
CMS1_k127_5755131_1	880073.Calab_0272	2.218e-09	69.0	COG1649@1|root,COG3023@1|root,COG3391@1|root,COG4412@1|root,COG1649@2|Bacteria,COG3023@2|Bacteria,COG3391@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	3.2.1.20,3.4.17.22,3.5.1.28	ko:K01187,ko:K01448,ko:K07752	ko00052,ko00500,ko01100,ko01503,map00052,map00500,map01100,map01503	M00727	R00028,R00801,R00802,R04112,R06087,R06088	RC00028,RC00049,RC00064,RC00077,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03036	-	GH31	-	Amidase_2
CMS1_k127_5755131_2	1353529.M899_2677	0.0003901	53.0	COG0729@1|root,COG0729@2|Bacteria,1QY1J@1224|Proteobacteria,430S6@68525|delta/epsilon subdivisions,2MU2E@213481|Bdellovibrionales,2WVNT@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Chaperone of endosialidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
CMS1_k127_5755131_0	869213.JCM21142_114591	1.366e-24	109.0	2DT8X@1|root,32UUQ@2|Bacteria,4NSYW@976|Bacteroidetes,47SF7@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5772034_0	1121904.ARBP01000007_gene3034	2.33e-65	228.0	COG0788@1|root,COG0788@2|Bacteria,4NEGJ@976|Bacteroidetes,47N6W@768503|Cytophagia	976|Bacteroidetes	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
CMS1_k127_5772034_4	221027.JO40_00135	2.302e-06	55.0	2AMV7@1|root,31CRX@2|Bacteria,2J8MV@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5772034_1	221027.JO40_00140	2.116e-42	162.0	COG1595@1|root,COG1595@2|Bacteria,2J7DE@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_5772034_2	744872.Spica_0334	8.377e-27	113.0	2AN0C@1|root,31CXK@2|Bacteria,2J95I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5772034_3	266762.HQ36_03880	4.138e-07	61.0	29A5Q@1|root,2ZX6Q@2|Bacteria,4NP43@976|Bacteroidetes,2FPGZ@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5772043_1	316274.Haur_1785	1.66e-53	201.0	292QY@1|root,2ZQ8Q@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5772043_0	316274.Haur_1784	3.828e-126	430.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
CMS1_k127_579414_1	1087481.AGFX01000037_gene4363	4.608e-18	92.0	COG1443@1|root,COG1443@2|Bacteria,1V6SB@1239|Firmicutes,4HJ2T@91061|Bacilli,26XCW@186822|Paenibacillaceae	91061|Bacilli	I	Nudix hydrolase	M1-740	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS1_k127_579414_0	1242864.D187_002741	1.371e-71	267.0	COG3119@1|root,COG3119@2|Bacteria,1PG5D@1224|Proteobacteria,4358J@68525|delta/epsilon subdivisions,2WZJN@28221|Deltaproteobacteria,2Z29X@29|Myxococcales	28221|Deltaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
CMS1_k127_5803245_1	675813.VIB_000039	3.936e-98	333.0	28MGF@1|root,2ZATP@2|Bacteria,1RBWI@1224|Proteobacteria,1SIPV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5803245_3	675813.VIB_000038	1.125e-27	121.0	2DGCN@1|root,2ZVF3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5803245_4	411490.ANACAC_03767	7.754e-09	62.0	COG1476@1|root,COG1476@2|Bacteria,1TNYC@1239|Firmicutes,248I9@186801|Clostridia	186801|Clostridia	K	DNA-binding helix-turn-helix protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_5803245_0	338966.Ppro_2358	1.397e-133	468.0	COG2204@1|root,COG2984@1|root,COG4191@1|root,COG2204@2|Bacteria,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
CMS1_k127_5803245_5	929506.CbC4_1900	2.351e-08	68.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,36DFY@31979|Clostridiaceae	186801|Clostridia	L	domain protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,Lactamase_B
CMS1_k127_5803245_2	1123057.P872_20775	6.723e-30	138.0	COG0515@1|root,COG3177@1|root,COG0515@2|Bacteria,COG3177@2|Bacteria,4NR8T@976|Bacteroidetes,47QX8@768503|Cytophagia	976|Bacteroidetes	KLT	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Pkinase
CMS1_k127_580801_0	573413.Spirs_2146	2.185e-236	739.0	COG0112@1|root,COG0112@2|Bacteria,2J5XQ@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
CMS1_k127_580801_1	1121930.AQXG01000004_gene2873	2.196e-22	99.0	COG0724@1|root,COG0724@2|Bacteria,4P4WZ@976|Bacteroidetes	976|Bacteroidetes	S	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
CMS1_k127_5827839_6	767817.Desgi_0451	4.25e-60	215.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,2602H@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
CMS1_k127_5827839_2	2325.TKV_c20980	2.476e-145	479.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
CMS1_k127_5827839_8	1278307.KB907037_gene653	1.586e-18	94.0	COG4976@1|root,COG4976@2|Bacteria,1QWSE@1224|Proteobacteria	1224|Proteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS1_k127_5827839_0	1089553.Tph_c04670	5.509e-273	861.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,42FKN@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
CMS1_k127_5827839_1	632518.Calow_0579	4.323e-169	541.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,42EU3@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
CMS1_k127_5827839_4	123214.PERMA_1324	4.303e-92	305.0	COG0740@1|root,COG0740@2|Bacteria,2G3IM@200783|Aquificae	200783|Aquificae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
CMS1_k127_5827839_7	665952.HMPREF1015_00453	5.659e-57	215.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,4H9Q8@91061|Bacilli,1ZBRE@1386|Bacillus	91061|Bacilli	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
CMS1_k127_5827839_3	509191.AEDB02000093_gene3416	1.298e-115	387.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,3WGKI@541000|Ruminococcaceae	186801|Clostridia	C	citrate synthase	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
CMS1_k127_5827839_9	1397696.KK211189_gene2556	1.587e-05	49.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5827839_5	694427.Palpr_0194	2.336e-80	273.0	COG0826@1|root,COG0826@2|Bacteria,4NEX7@976|Bacteroidetes,2FNE7@200643|Bacteroidia,22W2C@171551|Porphyromonadaceae	976|Bacteroidetes	O	Collagenase	prtQ	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
CMS1_k127_583545_0	192952.MM_1864	8.967e-61	214.0	arCOG03518@1|root,arCOG03518@2157|Archaea,2Y0DN@28890|Euryarchaeota,2NAXI@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_583545_1	105559.Nwat_1609	5.791e-23	99.0	COG0053@1|root,COG0053@2|Bacteria,1N8A3@1224|Proteobacteria,1SDJW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5838856_3	1150474.JQJI01000020_gene1559	1.782e-16	81.0	COG0639@1|root,COG0639@2|Bacteria,2GCVZ@200918|Thermotogae	200918|Thermotogae	T	PFAM metallophosphoesterase	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
CMS1_k127_5838856_1	1167006.UWK_00694	9.045e-134	452.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
CMS1_k127_5838856_0	697303.Thewi_2055	1.872e-143	466.0	COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,247JE@186801|Clostridia,42FMG@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
CMS1_k127_5838856_2	880073.Calab_1855	3.273e-93	323.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2NNW8@2323|unclassified Bacteria	2|Bacteria	L	DNA helicase	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
CMS1_k127_5840664_4	880071.Fleli_2002	9.134e-06	59.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ank_5,Big_3_2,Calx-beta,DUF4114,DUF4214,NB-ARC,Peptidase_M6,TPR_12,VCBS
CMS1_k127_5840664_3	1125725.HMPREF1325_2561	1.438e-13	86.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5840664_2	1348583.ATLH01000017_gene2669	4.49e-59	236.0	COG0075@1|root,COG0075@2|Bacteria,4PNT2@976|Bacteroidetes,1IKBJ@117743|Flavobacteriia,1F9TB@104264|Cellulophaga	976|Bacteroidetes	E	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5840664_0	1283300.ATXB01000001_gene901	2.14e-99	343.0	COG1404@1|root,COG2931@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4935@2|Bacteria,1MU7T@1224|Proteobacteria,1T2VQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	OQ	serine protease	avxIA	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind,P_proprotein,Peptidase_S8
CMS1_k127_5840664_1	1283300.ATXB01000001_gene901	6.793e-95	329.0	COG1404@1|root,COG2931@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4935@2|Bacteria,1MU7T@1224|Proteobacteria,1T2VQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	OQ	serine protease	avxIA	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind,P_proprotein,Peptidase_S8
CMS1_k127_5841554_10	992406.RIA_1307	4.766e-12	76.0	COG0811@1|root,COG0811@2|Bacteria,4NFIX@976|Bacteroidetes,1HXWI@117743|Flavobacteriia	976|Bacteroidetes	U	Mota tolq exbb proton channel	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
CMS1_k127_5841554_11	877418.ATWV01000004_gene1868	6.137e-07	57.0	COG0848@1|root,COG0848@2|Bacteria	2|Bacteria	U	biopolymer transport protein	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
CMS1_k127_5841554_13	572544.Ilyop_1268	8.413e-06	53.0	COG0848@1|root,COG0848@2|Bacteria,37A3D@32066|Fusobacteria	32066|Fusobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
CMS1_k127_5841554_7	215803.DB30_6384	1.054e-48	199.0	COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec
CMS1_k127_5841554_12	690597.JH730976_gene3938	1.661e-06	55.0	2EAQ8@1|root,334SG@2|Bacteria,1NCWC@1224|Proteobacteria,1SGVB@1236|Gammaproteobacteria,1YQID@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5841554_1	1168067.JAGP01000001_gene232	9.738e-124	402.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,460UY@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
CMS1_k127_5841554_6	1123518.ARWI01000001_gene1060	3.722e-59	210.0	COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,1S7BA@1236|Gammaproteobacteria,4619B@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
CMS1_k127_5841554_9	456442.Mboo_2092	6.551e-28	117.0	COG0784@1|root,arCOG02391@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	ko:K03413,ko:K07662,ko:K07667	ko01503,ko02020,ko02024,ko02030,map01503,map02020,map02024,map02030	M00447,M00454,M00506,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
CMS1_k127_5841554_5	1094980.Mpsy_2921	1.897e-61	217.0	COG0225@1|root,arCOG02816@2157|Archaea,2XWKA@28890|Euryarchaeota,2N9M6@224756|Methanomicrobia	224756|Methanomicrobia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
CMS1_k127_5841554_2	1304885.AUEY01000019_gene1182	5.239e-94	326.0	COG0357@1|root,COG0566@1|root,COG0357@2|Bacteria,COG0566@2|Bacteria,1QW0W@1224|Proteobacteria,43BQS@68525|delta/epsilon subdivisions,2WMFV@28221|Deltaproteobacteria,2MN58@213118|Desulfobacterales	28221|Deltaproteobacteria	JM	rRNA small subunit methyltransferase G	-	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB,SpoU_methylase
CMS1_k127_5841554_8	580340.Tlie_0581	6.719e-44	172.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,3T9T4@508458|Synergistetes	508458|Synergistetes	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
CMS1_k127_5841554_3	404380.Gbem_0837	2.443e-79	280.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,43T9B@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
CMS1_k127_5841554_4	1476973.JMMB01000007_gene2435	1.877e-68	239.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,25SZ3@186804|Peptostreptococcaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	lolD	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_5841554_0	1304284.L21TH_1732	1.917e-157	512.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,36DQZ@31979|Clostridiaceae	186801|Clostridia	J	metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
CMS1_k127_5843280_1	419665.Maeo_0208	1.366e-05	57.0	COG0457@1|root,COG1520@1|root,arCOG02556@2157|Archaea,arCOG03038@2157|Archaea	2157|Archaea	KLT	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PKD,PQQ_2,PQQ_3,TPR_12,TPR_16,TPR_2,TPR_8,TPR_9,Transglut_core2
CMS1_k127_5843280_0	1519464.HY22_13100	2.101e-64	239.0	COG2114@1|root,COG2114@2|Bacteria,1FFF9@1090|Chlorobi	1090|Chlorobi	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
CMS1_k127_5855921_1	5722.XP_001310118.1	2.864e-08	67.0	KOG0982@1|root,KOG0982@2759|Eukaryota	2759|Eukaryota	S	ADP-ribosylation factor binding	-	GO:0000910,GO:0000912,GO:0000915,GO:0001709,GO:0003002,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005856,GO:0005875,GO:0005938,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007275,GO:0007389,GO:0007423,GO:0007444,GO:0007447,GO:0007450,GO:0008017,GO:0008052,GO:0008092,GO:0008150,GO:0009653,GO:0009887,GO:0009888,GO:0009953,GO:0009987,GO:0010160,GO:0015630,GO:0015631,GO:0016043,GO:0016360,GO:0022402,GO:0022607,GO:0030029,GO:0030036,GO:0030154,GO:0030865,GO:0030866,GO:0031032,GO:0031532,GO:0032501,GO:0032502,GO:0032506,GO:0032991,GO:0035220,GO:0035222,GO:0035295,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044464,GO:0044837,GO:0045165,GO:0045177,GO:0045179,GO:0048190,GO:0048471,GO:0048513,GO:0048645,GO:0048646,GO:0048731,GO:0048856,GO:0048859,GO:0048869,GO:0051301,GO:0060429,GO:0060581,GO:0060582,GO:0061640,GO:0071840,GO:0071944,GO:0099568,GO:0099738	-	ko:K05286,ko:K07951,ko:K12485	ko00563,ko01100,ko04144,map00563,map01100,map04144	M00065	R05922	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko03036,ko04031,ko04131,ko04147	-	GT22	-	EF-hand_7,RBD-FIP
CMS1_k127_5855921_0	754027.HMPREF9554_00630	1.016e-243	772.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
CMS1_k127_5857256_1	906968.Trebr_0727	1.731e-30	128.0	2EF8C@1|root,3391B@2|Bacteria,2J6B9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5857256_0	177437.HRM2_48810	3.927e-298	925.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria,2MN2K@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
CMS1_k127_5857325_2	518766.Rmar_1702	4.713e-59	216.0	COG1162@1|root,COG1162@2|Bacteria,4NE5H@976|Bacteroidetes,1FIU8@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
CMS1_k127_5857325_3	1219035.NT2_01_04990	1.638e-09	65.0	COG2885@1|root,COG2885@2|Bacteria,1NB27@1224|Proteobacteria,2UIJ0@28211|Alphaproteobacteria,2K7N1@204457|Sphingomonadales	204457|Sphingomonadales	M	OmpA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
CMS1_k127_5857325_0	1168034.FH5T_17230	6.725e-297	920.0	COG0129@1|root,COG0129@2|Bacteria,4NFHP@976|Bacteroidetes,2FMCC@200643|Bacteroidia	976|Bacteroidetes	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
CMS1_k127_5857325_1	1123508.JH636443_gene5093	3.616e-72	250.0	COG3298@1|root,COG3298@2|Bacteria,2IWT7@203682|Planctomycetes	203682|Planctomycetes	L	3'-5' exonuclease related to the exonuclease domain of PolB	-	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
CMS1_k127_5866648_0	387092.NIS_1346	1.002e-72	265.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2YMJS@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,NIT,Response_reg
CMS1_k127_5868240_1	272563.CD630_33550	1.245e-54	196.0	COG0778@1|root,COG0778@2|Bacteria,1V3YJ@1239|Firmicutes,24BKH@186801|Clostridia	186801|Clostridia	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
CMS1_k127_5868240_2	1122179.KB890480_gene3108	1.155e-47	181.0	COG1876@1|root,COG1876@2|Bacteria,4NFA4@976|Bacteroidetes	976|Bacteroidetes	M	D-alanyl-D-alanine carboxypeptidase	vanY	-	-	-	-	-	-	-	-	-	-	-	VanY
CMS1_k127_5868240_0	1122134.KB893651_gene2367	1.639e-64	227.0	COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,1S02F@1236|Gammaproteobacteria,1XIIY@135619|Oceanospirillales	135619|Oceanospirillales	S	PFAM O-methyltransferase, family 3	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
CMS1_k127_5869043_0	177437.HRM2_42890	1.186e-95	320.0	COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,42NVQ@68525|delta/epsilon subdivisions,2WJFT@28221|Deltaproteobacteria,2MHX5@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
CMS1_k127_5869043_1	589865.DaAHT2_0705	2.139e-17	86.0	arCOG05277@1|root,336C4@2|Bacteria,1NZZE@1224|Proteobacteria,43162@68525|delta/epsilon subdivisions,2WWEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5870923_2	1209989.TepiRe1_2456	3.748e-23	101.0	COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,42H6Q@68295|Thermoanaerobacterales	186801|Clostridia	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
CMS1_k127_5870923_0	1047013.AQSP01000092_gene327	5.818e-184	584.0	COG0701@1|root,COG0701@2|Bacteria,2NP6A@2323|unclassified Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
CMS1_k127_5870923_1	1499967.BAYZ01000050_gene2839	7.285e-34	133.0	COG0640@1|root,COG0640@2|Bacteria,2NQ13@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	3.6.4.12	ko:K03655,ko:K03892	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	HTH_20,HTH_5
CMS1_k127_5876579_0	643562.Daes_0819	1.201e-76	276.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2M7RA@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM chemotaxis	mcp34H-6	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
CMS1_k127_5876579_1	1345695.CLSA_c20390	9.52e-29	128.0	COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,36ITK@31979|Clostridiaceae	186801|Clostridia	NT	Chemotaxis protein cheW	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
CMS1_k127_5876579_2	261292.Nit79A3_0924	7.828e-05	46.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,372QZ@32003|Nitrosomonadales	28216|Betaproteobacteria	NT	Histidine kinase	cheA	GO:0003674,GO:0005488,GO:0005515,GO:0019904	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,CheY-binding,H-kinase_dim,HATPase_c,Hpt
CMS1_k127_5881006_0	1121097.JCM15093_1394	2.28e-132	430.0	COG1052@1|root,COG1052@2|Bacteria,4NF1R@976|Bacteroidetes,2FMNY@200643|Bacteroidia,4AKA2@815|Bacteroidaceae	976|Bacteroidetes	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	ldhA	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
CMS1_k127_5881006_2	224325.AF_2299	3.525e-20	102.0	COG0558@1|root,arCOG00674@2157|Archaea	2157|Archaea	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
CMS1_k127_5881805_0	1191523.MROS_2574	5.641e-182	592.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria	2|Bacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
CMS1_k127_5881805_2	178306.PAE0579	1.955e-20	103.0	COG0535@1|root,arCOG00938@2157|Archaea,2XPPA@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
CMS1_k127_5894024_0	1190606.AJYG01000194_gene2769	7.625e-18	96.0	COG3064@1|root,COG3064@2|Bacteria,1QW8P@1224|Proteobacteria	1224|Proteobacteria	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Ntox15
CMS1_k127_5894024_1	449447.MAE_03780	5.396e-08	57.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8,Trypsin_2
CMS1_k127_5895357_0	694427.Palpr_2945	2.728e-28	126.0	2DC1B@1|root,2ZCDD@2|Bacteria,4NRQJ@976|Bacteroidetes,2FT3K@200643|Bacteroidia,22Y5M@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5895357_1	118161.KB235919_gene6465	9.152e-25	110.0	COG3409@1|root,COG3409@2|Bacteria,1G5EG@1117|Cyanobacteria	1117|Cyanobacteria	M	Cell wall hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
CMS1_k127_5897492_0	485916.Dtox_3037	3.104e-99	341.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,2600X@186807|Peptococcaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
CMS1_k127_5897492_1	1400520.LFAB_08425	1.562e-31	128.0	COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,4HIQP@91061|Bacilli,3F6I0@33958|Lactobacillaceae	91061|Bacilli	S	YqeY-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
CMS1_k127_5901035_5	720554.Clocl_2527	1.78e-18	90.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,3WK9F@541000|Ruminococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
CMS1_k127_5901035_4	639282.DEFDS_1218	5.909e-51	191.0	COG0543@1|root,COG0543@2|Bacteria,2GF6C@200930|Deferribacteres	200930|Deferribacteres	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
CMS1_k127_5901035_0	1232410.KI421422_gene2016	2.789e-131	449.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,43S7U@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Transglycosylase	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
CMS1_k127_5901035_1	526224.Bmur_0623	1.122e-108	358.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	-	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
CMS1_k127_5901035_3	96561.Dole_2799	5.849e-55	209.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2MKKR@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Alpha beta hydrolase	agmH	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS1_k127_5901035_2	316067.Geob_0563	2.555e-93	317.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria,43STU@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
CMS1_k127_5901035_6	1121889.AUDM01000015_gene2035	4.888e-09	68.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1HYZK@117743|Flavobacteriia,2NSDI@237|Flavobacterium	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg,TPR_12,TPR_8
CMS1_k127_5907696_0	526224.Bmur_2761	5.906e-20	104.0	COG0457@1|root,COG0457@2|Bacteria,2J5PC@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_2,TPR_6,TPR_8
CMS1_k127_592338_2	1162668.LFE_1204	9.032e-05	53.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02457,ko:K02458,ko:K02459,ko:K02655,ko:K10926	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	ComP_DUS,N_methyl,T2SSI,T2SSJ
CMS1_k127_592338_0	344747.PM8797T_14294	3.175e-19	100.0	COG3156@1|root,COG3156@2|Bacteria,2IXHV@203682|Planctomycetes	203682|Planctomycetes	U	Type II secretion system (T2SS), protein K	-	-	-	-	-	-	-	-	-	-	-	-	T2SSK
CMS1_k127_592338_1	530564.Psta_3610	3.826e-09	69.0	COG4972@1|root,COG4972@2|Bacteria,2IWXB@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM type IV pilus assembly protein PilM	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
CMS1_k127_5929042_0	44251.PDUR_11275	1.012e-29	137.0	COG3321@1|root,COG3321@2|Bacteria,1VU8Z@1239|Firmicutes,4I2RT@91061|Bacilli,26UUG@186822|Paenibacillaceae	91061|Bacilli	Q	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt
CMS1_k127_5936996_0	545243.BAEV01000001_gene3232	1.316e-137	449.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,36ERG@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
CMS1_k127_5936996_1	797209.ZOD2009_14481	1.177e-27	123.0	2DZ8E@1|root,2N5II@2157|Archaea,2XVK9@28890|Euryarchaeota,23U2M@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5936996_2	314230.DSM3645_07450	9.346e-20	93.0	COG0727@1|root,COG0727@2|Bacteria,2IZU5@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
CMS1_k127_5939515_1	391623.TERMP_00320	3.881e-51	187.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,242TB@183968|Thermococci	183968|Thermococci	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
CMS1_k127_5939515_0	909663.KI867149_gene3199	1.88e-113	376.0	COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2WJ4C@28221|Deltaproteobacteria,2MQ6F@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3391	Radical_SAM
CMS1_k127_5939515_2	909663.KI867149_gene3198	8.476e-45	169.0	COG1427@1|root,COG1427@2|Bacteria,1RCS0@1224|Proteobacteria,42SPW@68525|delta/epsilon subdivisions,2WP7F@28221|Deltaproteobacteria,2MQM4@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
CMS1_k127_5944068_2	553177.CAPSP0001_2834	3.344e-07	65.0	COG0075@1|root,COG0075@2|Bacteria,4NWZ5@976|Bacteroidetes,1I5X2@117743|Flavobacteriia,1ERCN@1016|Capnocytophaga	976|Bacteroidetes	E	2-aminoethylphosphonate-pyruvate transaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5018
CMS1_k127_5944068_0	1348583.ATLH01000017_gene2673	7.827e-54	219.0	COG0075@1|root,COG3291@1|root,COG0075@2|Bacteria,COG3291@2|Bacteria,4PKJH@976|Bacteroidetes,1IJAY@117743|Flavobacteriia,1FAMT@104264|Cellulophaga	976|Bacteroidetes	E	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Malectin,PKD
CMS1_k127_5944068_3	1443665.JACA01000124_gene2055	0.0001413	56.0	COG4886@1|root,COG4886@2|Bacteria,4P5G3@976|Bacteroidetes,1IAJW@117743|Flavobacteriia,2YJVK@290174|Aquimarina	976|Bacteroidetes	KLT	Leucine-rich repeats, outliers	-	-	-	-	-	-	-	-	-	-	-	-	LRR_8
CMS1_k127_5944068_1	771875.Ferpe_0702	4.999e-27	130.0	COG1470@1|root,COG1520@1|root,COG1470@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,SBBP,TonB_dep_Rec
CMS1_k127_5948654_2	487796.Flav2ADRAFT_1529	9.031e-24	116.0	COG2114@1|root,COG2114@2|Bacteria,4NF1F@976|Bacteroidetes,1HZ1W@117743|Flavobacteriia	976|Bacteroidetes	T	Guanylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,Response_reg
CMS1_k127_5948654_1	1173026.Glo7428_4200	2.306e-33	146.0	COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1FZWU@1117|Cyanobacteria	1117|Cyanobacteria	T	Diguanylate cyclase with PAS PAC and GAF sensors	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS,PAS_3,PAS_9
CMS1_k127_5948654_0	906968.Trebr_0196	1.729e-37	148.0	COG0004@1|root,COG0643@1|root,COG0004@2|Bacteria,COG0643@2|Bacteria,2JA63@203691|Spirochaetes	203691|Spirochaetes	NPT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,HATPase_c,Hpt
CMS1_k127_5949244_2	1207058.L53_01675	4.55e-58	220.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
CMS1_k127_5949244_3	1207058.L53_01680	4.83e-54	202.0	COG0438@1|root,COG0438@2|Bacteria,1RF3D@1224|Proteobacteria,2UMXB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5949244_1	1207058.L53_01665	7.493e-78	276.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_5,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,RgpF
CMS1_k127_5949244_0	1207058.L53_01660	3.764e-98	329.0	COG2604@1|root,COG2604@2|Bacteria,1R556@1224|Proteobacteria	1224|Proteobacteria	M	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,MAF_flag10
CMS1_k127_5951879_1	1443122.Z958_12980	2.334e-24	116.0	COG1716@1|root,COG1716@2|Bacteria,1TS4P@1239|Firmicutes,24BY6@186801|Clostridia,36GIF@31979|Clostridiaceae	186801|Clostridia	T	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C11
CMS1_k127_5951879_2	535289.Dtpsy_0708	2.318e-15	83.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,2VKZ3@28216|Betaproteobacteria,4AB1D@80864|Comamonadaceae	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
CMS1_k127_5951879_0	1304888.ATWF01000001_gene1920	2.704e-159	508.0	COG0059@1|root,COG0059@2|Bacteria,2GEM8@200930|Deferribacteres	200930|Deferribacteres	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
CMS1_k127_5953417_1	1232437.KL662011_gene1491	3.719e-07	60.0	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,42V1I@68525|delta/epsilon subdivisions,2WRH0@28221|Deltaproteobacteria,2MKP1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
CMS1_k127_5953417_0	589873.EP13_13555	1.422e-79	297.0	COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,464UY@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Adenylate cyclase	cyaA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365	Adenyl_cycl_N,Adenylate_cycl
CMS1_k127_5980637_1	759914.BP951000_0339	4.212e-42	156.0	COG1004@1|root,COG1004@2|Bacteria,2J6SD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
CMS1_k127_5980637_0	1047013.AQSP01000073_gene1098	3.814e-84	285.0	COG1611@1|root,COG1611@2|Bacteria,2NP7M@2323|unclassified Bacteria	2|Bacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
CMS1_k127_5983970_0	1121448.DGI_1603	2.024e-50	188.0	COG0834@1|root,COG0834@2|Bacteria,1RCKS@1224|Proteobacteria,436T3@68525|delta/epsilon subdivisions,2X1GK@28221|Deltaproteobacteria,2MF11@213115|Desulfovibrionales	28221|Deltaproteobacteria	ET	ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_5983970_2	1382304.JNIL01000001_gene3508	1.84e-05	51.0	COG3620@1|root,COG3620@2|Bacteria,1UKAW@1239|Firmicutes	1239|Firmicutes	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_5983970_1	1396418.BATQ01000009_gene3827	9.605e-15	77.0	2DTBC@1|root,33JIE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_598729_1	665571.STHERM_c16600	4.558e-19	89.0	COG1993@1|root,COG1993@2|Bacteria,2JB3N@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
CMS1_k127_598729_0	272562.CA_C3590	1.368e-86	300.0	COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,36EA5@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
CMS1_k127_5996739_0	1094508.Tsac_1889	3.238e-49	184.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42G4B@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
CMS1_k127_6000405_0	1480694.DC28_07120	1.355e-66	232.0	COG0522@1|root,COG0522@2|Bacteria,2J6UK@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
CMS1_k127_6000405_1	1457393.AZ09_00420	1.055e-64	231.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,2JRG6@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
CMS1_k127_6000405_2	1443665.JACA01000013_gene4201	1.134e-07	58.0	2EB3B@1|root,33543@2|Bacteria,4NXCQ@976|Bacteroidetes,1I4V4@117743|Flavobacteriia,2YJ30@290174|Aquimarina	976|Bacteroidetes	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
CMS1_k127_6019694_0	449447.MAE_03780	5.984e-13	79.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8,Trypsin_2
CMS1_k127_6028725_1	696747.NIES39_C01090	5.028e-48	181.0	COG2199@1|root,COG2202@1|root,COG3437@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,COG3706@2|Bacteria,1G2A0@1117|Cyanobacteria,1H8JI@1150|Oscillatoriales	1117|Cyanobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_4,PAS_9,Response_reg
CMS1_k127_6028725_0	580327.Tthe_1727	2.033e-54	203.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,42EQH@68295|Thermoanaerobacterales	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	rbsR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
CMS1_k127_6028833_0	1499967.BAYZ01000050_gene2821	4.041e-225	706.0	COG0281@1|root,COG0281@2|Bacteria,2NNV3@2323|unclassified Bacteria	2|Bacteria	C	Malic enzyme, NAD binding domain	mez_1	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
CMS1_k127_6028833_1	648996.Theam_0603	1.107e-102	341.0	COG1951@1|root,COG1951@2|Bacteria,2G3JI@200783|Aquificae	200783|Aquificae	C	hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
CMS1_k127_6028833_2	649764.HMPREF0762_02000	8.24e-71	243.0	COG1838@1|root,COG1838@2|Bacteria,2GK6D@201174|Actinobacteria,4CXED@84998|Coriobacteriia	84998|Coriobacteriia	C	Fumarase C-terminus	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
CMS1_k127_6028833_3	1121459.AQXE01000006_gene132	2.162e-54	206.0	COG0079@1|root,COG0079@2|Bacteria,1PDPK@1224|Proteobacteria,436QP@68525|delta/epsilon subdivisions,2X1D4@28221|Deltaproteobacteria,2METE@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
CMS1_k127_6028833_4	1278309.KB907108_gene1625	3.113e-12	76.0	28KVB@1|root,2ZABY@2|Bacteria,1R4BA@1224|Proteobacteria,1SXPU@1236|Gammaproteobacteria,1XP0C@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_603548_0	331678.Cphamn1_0644	2.786e-142	462.0	COG2873@1|root,COG2873@2|Bacteria,1FDPZ@1090|Chlorobi	2|Bacteria	H	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	metY-3	-	2.5.1.48,2.5.1.49	ko:K01739,ko:K01740	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01287,R01288,R02508,R03217,R03260,R04859,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
CMS1_k127_603548_2	1150621.SMUL_3091	1.726e-34	137.0	COG1310@1|root,COG1310@2|Bacteria,1N3TI@1224|Proteobacteria,42TY4@68525|delta/epsilon subdivisions,2YQAW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Mov34 MPN PAD-1 family	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
CMS1_k127_603548_1	1280692.AUJL01000037_gene388	3.931e-44	181.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,36DM6@31979|Clostridiaceae	186801|Clostridia	P	Transporter, CPA2 family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
CMS1_k127_603548_3	906968.Trebr_1705	7.118e-16	91.0	COG1762@1|root,COG1762@2|Bacteria,2J7SC@203691|Spirochaetes	203691|Spirochaetes	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
CMS1_k127_6044132_0	1408424.JHYI01000006_gene413	2.45e-43	170.0	COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,4HAA1@91061|Bacilli,1ZBVG@1386|Bacillus	91061|Bacilli	J	Methyltransferase	ywbD	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
CMS1_k127_6044132_2	176279.SERP2349	7.322e-13	73.0	COG0346@1|root,COG0346@2|Bacteria,1V422@1239|Firmicutes,4HH25@91061|Bacilli,4GZ4Z@90964|Staphylococcaceae	91061|Bacilli	E	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor	fosB	GO:0003674,GO:0003824,GO:0004364,GO:0008150,GO:0016740,GO:0016765,GO:0042221,GO:0046677,GO:0050896	-	ko:K11210,ko:K21252	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Glyoxalase
CMS1_k127_6044132_1	290512.Paes_1739	1.664e-39	148.0	COG0449@1|root,COG0449@2|Bacteria,1FEMH@1090|Chlorobi	1090|Chlorobi	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
CMS1_k127_6060458_0	357809.Cphy_2875	6.174e-137	445.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,21XSB@1506553|Lachnoclostridium	186801|Clostridia	F	Phosphoglycerate kinase	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
CMS1_k127_6060458_1	762903.Pedsa_3310	7.571e-32	131.0	COG0805@1|root,COG0805@2|Bacteria,4NEKM@976|Bacteroidetes,1INR5@117747|Sphingobacteriia	976|Bacteroidetes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
CMS1_k127_6068800_2	1319815.HMPREF0202_00127	7.126e-60	215.0	COG1175@1|root,COG1175@2|Bacteria,37C9U@32066|Fusobacteria	32066|Fusobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_6068800_1	264462.Bd1227	5.003e-77	274.0	COG1175@1|root,COG2182@1|root,COG1175@2|Bacteria,COG2182@2|Bacteria,1MXKR@1224|Proteobacteria,42UM4@68525|delta/epsilon subdivisions,2MTUJ@213481|Bdellovibrionales,2WQPJ@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	Sugar ABC transporter permease	malF	-	-	ko:K10109,ko:K15770,ko:K15771	ko02010,map02010	M00194,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22	-	-	BPD_transp_1,SBP_bac_8
CMS1_k127_6068800_0	1120998.AUFC01000012_gene496	3.549e-112	375.0	COG0668@1|root,COG0668@2|Bacteria,1TSHU@1239|Firmicutes,249AB@186801|Clostridia	186801|Clostridia	M	mechanosensitive ion channel	-	-	-	ko:K16053	-	-	-	-	ko00000,ko02000	1.A.23.4.5	-	-	MS_channel
CMS1_k127_6068800_3	573413.Spirs_2743	8.669e-51	194.0	COG2885@1|root,COG4254@1|root,COG2885@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	1.9.3.1	ko:K02275,ko:K03286	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.6,3.D.4.2,3.D.4.4,3.D.4.6	-	-	Big_2,COX2,COX2_TM,FecR,OmpA,TPR_16,fn3
CMS1_k127_6081985_0	237368.SCABRO_00570	2.182e-61	220.0	COG1242@1|root,COG1242@2|Bacteria,2IYIP@203682|Planctomycetes	203682|Planctomycetes	S	Radical_SAM C-terminal domain	-	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
CMS1_k127_6081985_4	272624.lpg1742	1.652e-09	62.0	2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6081985_2	929506.CbC4_2240	2.238e-20	97.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,36JIM@31979|Clostridiaceae	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
CMS1_k127_6081985_1	443143.GM18_4245	9.803e-50	183.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,42RJR@68525|delta/epsilon subdivisions,2WMK3@28221|Deltaproteobacteria,43UNE@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
CMS1_k127_6082079_4	1123274.KB899437_gene668	3.224e-38	154.0	COG3064@1|root,COG3064@2|Bacteria	2|Bacteria	M	translation initiation factor activity	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,PSCyt1,RNB,S1,WD40
CMS1_k127_6082079_2	748727.CLJU_c25500	6.065e-91	307.0	COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,36H9G@31979|Clostridiaceae	186801|Clostridia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
CMS1_k127_6082079_1	484019.THA_488	2.548e-119	392.0	COG0182@1|root,COG0182@2|Bacteria,2GCAP@200918|Thermotogae	200918|Thermotogae	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
CMS1_k127_6082079_3	1123508.JH636439_gene1809	8.59e-41	162.0	COG2172@1|root,COG2197@1|root,COG2172@2|Bacteria,COG2197@2|Bacteria,2IYG7@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,Response_reg
CMS1_k127_6082079_0	373903.Hore_10010	4.848e-168	536.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,3WA9U@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
CMS1_k127_6089604_2	879212.DespoDRAFT_02107	5.113e-61	218.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,42RU9@68525|delta/epsilon subdivisions,2WNP7@28221|Deltaproteobacteria,2MJU6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
CMS1_k127_6089604_1	1499967.BAYZ01000143_gene6124	9.104e-64	222.0	COG2077@1|root,COG2077@2|Bacteria,2NQ0A@2323|unclassified Bacteria	2|Bacteria	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0020012,GO:0030312,GO:0030682,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
CMS1_k127_6089604_3	88036.EFJ18557	5.685e-38	150.0	COG1739@1|root,KOG3299@2759|Eukaryota,37JR9@33090|Viridiplantae,3GF1Y@35493|Streptophyta	35493|Streptophyta	S	Ribosomal protein S5 domain 2-like superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0029
CMS1_k127_6089604_0	907348.TresaDRAFT_1929	2.252e-130	438.0	COG0366@1|root,COG0366@2|Bacteria,2J9X3@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_6092221_2	204669.Acid345_1154	4.283e-19	88.0	COG0741@1|root,COG0741@2|Bacteria,3Y84I@57723|Acidobacteria,2JNI1@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
CMS1_k127_6092221_4	1380390.JIAT01000001_gene4991	0.0001689	46.0	COG0741@1|root,COG1876@1|root,COG0741@2|Bacteria,COG1876@2|Bacteria,2I4JK@201174|Actinobacteria,4CQYM@84995|Rubrobacteria	84995|Rubrobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	SLT,VanY
CMS1_k127_6092221_0	1167006.UWK_00694	1.92e-124	435.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
CMS1_k127_6092221_1	390874.Tpet_0978	2.092e-44	184.0	COG3437@1|root,COG3437@2|Bacteria,2GCG4@200918|Thermotogae	200918|Thermotogae	KT	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,dCache_1
CMS1_k127_6092221_3	1123372.AUIT01000008_gene556	9.679e-09	57.0	COG1328@1|root,COG1328@2|Bacteria,2GI4Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Anaerobic ribonucleoside-triphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	NRDD
CMS1_k127_6097342_0	1167006.UWK_00694	1.406e-104	366.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
CMS1_k127_6132628_0	744872.Spica_0062	1.812e-135	451.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,2JAHT@203691|Spirochaetes	203691|Spirochaetes	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD_5
CMS1_k127_6132628_1	290402.Cbei_2610	2.066e-92	311.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,36EKX@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
CMS1_k127_6132628_2	309799.DICTH_0462	6.706e-32	130.0	COG0801@1|root,COG0801@2|Bacteria	2|Bacteria	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0041	FolB,HPPK
CMS1_k127_6132628_3	696281.Desru_1775	4.047e-19	97.0	COG1484@1|root,COG1484@2|Bacteria,1TPZX@1239|Firmicutes,24CFX@186801|Clostridia,2662M@186807|Peptococcaceae	186801|Clostridia	L	PFAM IstB domain protein ATP-binding protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
CMS1_k127_6140231_0	373903.Hore_16000	1.588e-13	81.0	COG1543@1|root,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,248UF@186801|Clostridia,3WB4T@53433|Halanaerobiales	186801|Clostridia	G	Glycosyl hydrolase family 57	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
CMS1_k127_6140328_3	1123242.JH636436_gene577	5.903e-18	91.0	COG0352@1|root,COG0352@2|Bacteria,2IY16@203682|Planctomycetes	203682|Planctomycetes	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Clp_N,TMP-TENI
CMS1_k127_6140328_2	247490.KSU1_D1030	1.104e-31	133.0	COG1385@1|root,COG1385@2|Bacteria,2IZRM@203682|Planctomycetes	203682|Planctomycetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
CMS1_k127_6140328_4	667014.Thein_1544	0.0008862	50.0	COG2834@1|root,COG2834@2|Bacteria,2GIEK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS1_k127_6140328_1	588581.Cpap_3170	3.108e-39	149.0	COG4401@1|root,COG4401@2|Bacteria,1VAID@1239|Firmicutes,24N1H@186801|Clostridia,3WPF1@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis	aroH	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
CMS1_k127_6140328_0	398512.JQKC01000002_gene1952	1.622e-93	314.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3WG99@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
CMS1_k127_6148759_3	744872.Spica_1905	1.32e-57	221.0	COG2208@1|root,COG2208@2|Bacteria,2J6MB@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	7TMR-DISM_7TM,SpoIIE
CMS1_k127_6148759_6	1410653.JHVC01000020_gene4557	3.989e-05	56.0	COG5002@1|root,COG5002@2|Bacteria,1TQV5@1239|Firmicutes,248PK@186801|Clostridia,36GNR@31979|Clostridiaceae	186801|Clostridia	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,PAS,PAS_9
CMS1_k127_6148759_1	720554.Clocl_0465	0.0	1180.0	COG3459@1|root,COG3459@2|Bacteria,1V191@1239|Firmicutes,24BR6@186801|Clostridia,3WHKW@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36,Glyco_transf_36
CMS1_k127_6148759_2	385682.AFSL01000008_gene2556	3.895e-64	236.0	COG2942@1|root,COG2942@2|Bacteria,4NEH7@976|Bacteroidetes,2FM9N@200643|Bacteroidia,3XJB1@558415|Marinilabiliaceae	976|Bacteroidetes	G	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	bfce	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
CMS1_k127_6148759_0	1280390.CBQR020000158_gene4221	0.0	1277.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,4HDVR@91061|Bacilli,275SH@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl transferase	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
CMS1_k127_6148759_4	1133850.SHJG_0182	4.203e-48	183.0	COG0395@1|root,COG0395@2|Bacteria,2GMTH@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter (Permease)	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_6148759_5	1123239.KB898641_gene104	1.195e-40	158.0	COG1175@1|root,COG1175@2|Bacteria,1TRSP@1239|Firmicutes,4HDJS@91061|Bacilli	91061|Bacilli	G	permease	araP	-	-	ko:K17235	ko02010,map02010	M00602	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.34	-	-	BPD_transp_1
CMS1_k127_6153260_0	1408473.JHXO01000009_gene3474	8.02e-34	136.0	2E6GM@1|root,3313V@2|Bacteria,4NT39@976|Bacteroidetes,2FZCY@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6153260_1	1123057.P872_20775	2.234e-33	148.0	COG0515@1|root,COG3177@1|root,COG0515@2|Bacteria,COG3177@2|Bacteria,4NR8T@976|Bacteroidetes,47QX8@768503|Cytophagia	976|Bacteroidetes	KLT	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Pkinase
CMS1_k127_6159424_1	665571.STHERM_c13740	5.69e-280	870.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6WY@203691|Spirochaetes	203691|Spirochaetes	C	Iron only hydrogenase large subunit, C-terminal domain	hymC	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3
CMS1_k127_6159424_0	1313304.CALK_0978	2.631e-301	932.0	COG1894@1|root,COG1894@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	hymB	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
CMS1_k127_6159424_6	1313304.CALK_0977	1.285e-50	182.0	COG3411@1|root,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K17992	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
CMS1_k127_6159424_7	158190.SpiGrapes_2476	3.293e-43	164.0	COG0642@1|root,COG2205@2|Bacteria,2J8FP@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
CMS1_k127_6159424_4	665571.STHERM_c13780	8.905e-69	237.0	COG1905@1|root,COG1905@2|Bacteria,2J7IH@203691|Spirochaetes	203691|Spirochaetes	C	Respiratory-chain NADH dehydrogenase 24 Kd subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
CMS1_k127_6159424_5	573413.Spirs_1311	1.139e-52	195.0	COG0613@1|root,COG0613@2|Bacteria,2J7WK@203691|Spirochaetes	203691|Spirochaetes	S	PFAM PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP,PHP_C
CMS1_k127_6159424_8	545695.TREAZ_1590	4.455e-28	116.0	COG4109@1|root,COG4109@2|Bacteria,2J8TR@203691|Spirochaetes	203691|Spirochaetes	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpr_kinase_N
CMS1_k127_6159424_3	889378.Spiaf_2401	1.226e-91	310.0	COG2172@1|root,COG2524@1|root,COG2172@2|Bacteria,COG2524@2|Bacteria,2J63A@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c
CMS1_k127_6159424_10	1307761.L21SP2_0269	5.502e-11	68.0	COG4109@1|root,COG4109@2|Bacteria,2J94G@203691|Spirochaetes	203691|Spirochaetes	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6159424_2	665571.STHERM_c17990	5.823e-115	380.0	COG0502@1|root,COG0502@2|Bacteria,2J61V@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
CMS1_k127_6159424_9	1121930.AQXG01000002_gene1986	4.668e-28	132.0	COG2366@1|root,COG2366@2|Bacteria,4NEIX@976|Bacteroidetes,1IPU7@117747|Sphingobacteriia	976|Bacteroidetes	S	COG2366 Protein related to penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
CMS1_k127_6162031_5	1407650.BAUB01000007_gene1541	1.256e-30	124.0	COG0292@1|root,COG0292@2|Bacteria,1G5NZ@1117|Cyanobacteria,1H0HJ@1129|Synechococcus	1117|Cyanobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
CMS1_k127_6162031_6	1089553.Tph_c13320	5.675e-14	74.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,42H52@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
CMS1_k127_6162031_3	246194.CHY_1578	1.741e-44	168.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,42G8T@68295|Thermoanaerobacterales	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
CMS1_k127_6162031_0	639282.DEFDS_1504	4.789e-243	766.0	COG0441@1|root,COG0441@2|Bacteria,2GEP2@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
CMS1_k127_6162031_4	273068.TTE2163	3.412e-44	171.0	COG1922@1|root,COG1922@2|Bacteria,1V3QV@1239|Firmicutes,24AQ3@186801|Clostridia,42FEU@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid	tarA	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB,PS_pyruv_trans
CMS1_k127_6162031_2	880073.Calab_3009	7.315e-51	197.0	COG2208@1|root,COG2208@2|Bacteria,2NQW9@2323|unclassified Bacteria	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	CHASE2,GAF_2,HATPase_c_2,SpoIIE
CMS1_k127_6162031_1	744872.Spica_1884	2.155e-174	571.0	COG0475@1|root,COG1762@1|root,COG0475@2|Bacteria,COG1762@2|Bacteria,2J603@203691|Spirochaetes	203691|Spirochaetes	GPT	PFAM Sodium hydrogen exchanger family	napA-1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
CMS1_k127_6172866_0	929558.SMGD1_2712	2.158e-196	637.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YR2T@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
CMS1_k127_6172866_4	1304888.ATWF01000002_gene339	7.979e-81	277.0	COG2834@1|root,COG2834@2|Bacteria,2GG12@200930|Deferribacteres	200930|Deferribacteres	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
CMS1_k127_6172866_2	1121396.KB892946_gene2895	5.346e-99	340.0	COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,42PXB@68525|delta/epsilon subdivisions,2WJKN@28221|Deltaproteobacteria,2MJ1J@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
CMS1_k127_6172866_5	1196323.ALKF01000200_gene2826	2.208e-65	235.0	COG1893@1|root,COG1893@2|Bacteria,1VGA2@1239|Firmicutes,4HPXE@91061|Bacilli,26RN1@186822|Paenibacillaceae	91061|Bacilli	H	Ketopantoate reductase PanE/ApbA	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA
CMS1_k127_6172866_3	755732.Fluta_3725	9.642e-88	300.0	COG0451@1|root,COG0451@2|Bacteria,4NG8C@976|Bacteroidetes,1HZ1S@117743|Flavobacteriia,2PBK5@246874|Cryomorphaceae	976|Bacteroidetes	M	NmrA-like family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD,Epimerase
CMS1_k127_6172866_6	456442.Mboo_0396	1.835e-25	111.0	COG1846@1|root,arCOG03182@2157|Archaea	2157|Archaea	K	Regulatory protein MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
CMS1_k127_6172866_1	526218.Sterm_0103	3.178e-162	519.0	COG1171@1|root,COG1171@2|Bacteria,378K1@32066|Fusobacteria	32066|Fusobacteria	E	Threonine dehydratase	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
CMS1_k127_6187789_0	589865.DaAHT2_0173	1.1e-322	1000.0	COG3968@1|root,COG3968@2|Bacteria,1QUKF@1224|Proteobacteria,42PBH@68525|delta/epsilon subdivisions,2WJZG@28221|Deltaproteobacteria,2MMWW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM glutamine synthetase catalytic region	glnN	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
CMS1_k127_6187789_3	289376.THEYE_A1686	7.284e-89	305.0	COG0067@1|root,COG0067@2|Bacteria	2|Bacteria	E	L-glutamate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6187789_1	1123288.SOV_2c05660	1.656e-272	846.0	COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,1TQ0B@1239|Firmicutes,4H23B@909932|Negativicutes	909932|Negativicutes	E	Glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,Fer4_9,Glu_synthase
CMS1_k127_6187789_2	1232410.KI421426_gene1331	8.068e-262	827.0	COG0070@1|root,COG0493@1|root,COG1145@1|root,COG0070@2|Bacteria,COG0493@2|Bacteria,COG1145@2|Bacteria,1PBEZ@1224|Proteobacteria,42NFW@68525|delta/epsilon subdivisions,2WIQE@28221|Deltaproteobacteria,43TK8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3,ThiF
CMS1_k127_6191858_2	643648.Slip_1875	1.281e-120	397.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,42JPF@68298|Syntrophomonadaceae	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
CMS1_k127_6191858_5	880073.Calab_0100	5.267e-32	137.0	COG0123@1|root,COG0123@2|Bacteria,2NRDM@2323|unclassified Bacteria	2|Bacteria	BQ	including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
CMS1_k127_6191858_1	334545.CCMG01000008_gene754	8.961e-122	408.0	COG2227@1|root,COG4797@1|root,COG2227@2|Bacteria,COG4797@2|Bacteria,1QU8H@1224|Proteobacteria,2TWMI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	MethyTransf_Reg,Methyltransf_25,Methyltransf_31
CMS1_k127_6191858_4	574087.Acear_0257	3.834e-35	138.0	COG1516@1|root,COG1516@2|Bacteria,1VA8K@1239|Firmicutes,24MRW@186801|Clostridia,3WAV1@53433|Halanaerobiales	186801|Clostridia	N	TIGRFAM flagellar biosynthetic protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
CMS1_k127_6191858_3	694431.DESACE_01995	2.151e-95	320.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WRX9@28221|Deltaproteobacteria,2M70Q@213113|Desulfurellales	28221|Deltaproteobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
CMS1_k127_6191858_0	1121422.AUMW01000001_gene2336	1.309e-187	597.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,260XG@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
CMS1_k127_6193979_0	545695.TREAZ_2599	2.732e-101	339.0	COG1235@1|root,COG1235@2|Bacteria,2J6YX@203691|Spirochaetes	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,Lactamase_B_2,Response_reg
CMS1_k127_6193979_1	469617.FUAG_02174	1.379e-45	174.0	COG0419@1|root,COG0419@2|Bacteria,3797C@32066|Fusobacteria	32066|Fusobacteria	L	AAA domain	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_23
CMS1_k127_6194196_3	247490.KSU1_C0988	4.462e-208	657.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2IX43@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
CMS1_k127_6194196_7	340099.Teth39_0343	6.449e-127	420.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,42EW9@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
CMS1_k127_6194196_12	1069080.KB913028_gene245	4.715e-40	165.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,4H4HE@909932|Negativicutes	909932|Negativicutes	M	Peptidase, M23 family	envC_2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS1_k127_6194196_14	1121406.JAEX01000002_gene916	8.463e-26	111.0	COG2204@1|root,COG2204@2|Bacteria,1NBTR@1224|Proteobacteria,42V7Q@68525|delta/epsilon subdivisions,2WR8M@28221|Deltaproteobacteria,2MBT7@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
CMS1_k127_6194196_13	102232.GLO73106DRAFT_00009180	1.644e-33	132.0	COG0730@1|root,COG0730@2|Bacteria,1G8K7@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
CMS1_k127_6194196_0	642492.Clole_2855	1.065e-242	759.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CMS1_k127_6194196_4	445971.ANASTE_01889	7.052e-161	513.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,25VC9@186806|Eubacteriaceae	186801|Clostridia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
CMS1_k127_6194196_1	632292.Calhy_1989	8.919e-237	744.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,42EZI@68295|Thermoanaerobacterales	186801|Clostridia	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
CMS1_k127_6194196_5	1121439.dsat_1613	1.141e-132	436.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,42Q1H@68525|delta/epsilon subdivisions,2WK7W@28221|Deltaproteobacteria,2M8T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	pfam mofrl	Glyctk	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
CMS1_k127_6194196_15	744872.Spica_2497	1.668e-18	94.0	COG0457@1|root,COG0457@2|Bacteria,2J8Y5@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
CMS1_k127_6194196_2	158190.SpiGrapes_2025	3.873e-210	660.0	COG2610@1|root,COG2610@2|Bacteria,2J5W9@203691|Spirochaetes	203691|Spirochaetes	EG	Gluconate	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
CMS1_k127_6194196_8	158190.SpiGrapes_2024	1.765e-80	276.0	COG1237@1|root,COG1237@2|Bacteria,2J831@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
CMS1_k127_6194196_9	1123274.KB899406_gene1267	4.064e-51	189.0	COG2186@1|root,COG2186@2|Bacteria,2J9RW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
CMS1_k127_6194196_11	1304284.L21TH_1266	2.279e-45	169.0	COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,24JAK@186801|Clostridia,36IWM@31979|Clostridiaceae	186801|Clostridia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
CMS1_k127_6194196_6	572544.Ilyop_1107	6.08e-132	424.0	COG0428@1|root,COG0428@2|Bacteria,379W9@32066|Fusobacteria	32066|Fusobacteria	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
CMS1_k127_6194196_10	1487921.DP68_14315	1.718e-49	181.0	COG0778@1|root,COG0778@2|Bacteria,1V3FH@1239|Firmicutes,24HM3@186801|Clostridia,36JRE@31979|Clostridiaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS1_k127_6194196_16	589924.Ferp_1218	3.2e-11	74.0	arCOG04005@1|root,arCOG04005@2157|Archaea,2XX7Q@28890|Euryarchaeota,246K5@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6202850_0	385682.AFSL01000102_gene67	2.151e-89	336.0	COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,2FMBN@200643|Bacteroidia,3XJ8V@558415|Marinilabiliaceae	976|Bacteroidetes	I	Biotin carboxylase C-terminal domain	accC	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K01961,ko:K01965	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00373,M00376,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
CMS1_k127_6205594_0	997884.HMPREF1068_00284	5.62e-06	55.0	COG1595@1|root,COG1595@2|Bacteria,4NRYG@976|Bacteroidetes,2FSMX@200643|Bacteroidia,4ARX9@815|Bacteroidaceae	976|Bacteroidetes	K	RNA polymerase sigma-70 factor, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_6211132_5	933262.AXAM01000015_gene98	5.807e-44	168.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2MKZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_6211132_6	1341151.ASZU01000004_gene285	8.034e-29	130.0	COG0739@1|root,COG0739@2|Bacteria,1V32Q@1239|Firmicutes,4HGG1@91061|Bacilli,27BQH@186824|Thermoactinomycetaceae	91061|Bacilli	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS1_k127_6211132_9	865938.Weevi_1007	0.0002282	50.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,1HYK6@117743|Flavobacteriia	976|Bacteroidetes	M	Belongs to the ompA family	yiaD	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
CMS1_k127_6211132_0	572477.Alvin_0940	7.396e-140	454.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,1X28H@135613|Chromatiales	135613|Chromatiales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
CMS1_k127_6211132_4	497965.Cyan7822_4621	1.961e-46	182.0	COG2199@1|root,COG4191@1|root,COG5002@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1GITA@1117|Cyanobacteria,3KJKN@43988|Cyanothece	1117|Cyanobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
CMS1_k127_6211132_1	1245469.S58_71030	6.475e-62	226.0	COG3173@1|root,COG3173@2|Bacteria,1R7XK@1224|Proteobacteria,2TTWB@28211|Alphaproteobacteria,3JSZR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Ecdysteroid kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,EcKinase
CMS1_k127_6211132_3	1279017.AQYJ01000028_gene2277	5.635e-52	212.0	COG0366@1|root,COG0366@2|Bacteria,1MVQA@1224|Proteobacteria,1RPA4@1236|Gammaproteobacteria,46654@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG0366 Glycosidases	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amyl_C2,Alpha-amylase,Alpha-amylase_C,CBM26,CBM_20,CBM_48,PKD
CMS1_k127_6211132_7	1296416.JACB01000057_gene1504	7.554e-10	73.0	COG1470@1|root,COG3342@1|root,COG1470@2|Bacteria,COG3342@2|Bacteria,4PM83@976|Bacteroidetes,1IJM6@117743|Flavobacteriia,2YM75@290174|Aquimarina	976|Bacteroidetes	S	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	MAM,Reprolysin_4,Reprolysin_5,fn3
CMS1_k127_6211132_2	997884.HMPREF1068_04218	4.644e-57	228.0	COG4870@1|root,COG4870@2|Bacteria,4NKEE@976|Bacteroidetes,2FRKR@200643|Bacteroidia	976|Bacteroidetes	O	Belongs to the peptidase C1 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6216212_3	1232410.KI421428_gene1164	2.057e-107	355.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,43SC9@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Amino acid kinase family	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
CMS1_k127_6216212_10	384765.SIAM614_17709	0.0003284	46.0	2AGK3@1|root,316T8@2|Bacteria,1NICS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6216212_9	406124.ACPC01000009_gene1545	1.69e-06	61.0	COG3437@1|root,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,4HB2P@91061|Bacilli,1ZBP5@1386|Bacillus	91061|Bacilli	KT	HD domain	rpfG	-	-	-	-	-	-	-	-	-	-	-	HAMP,HD,HD_5
CMS1_k127_6216212_8	411154.GFO_0229	4.915e-28	129.0	COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1HX46@117743|Flavobacteriia	976|Bacteroidetes	M	Peptidase, M23	mepM_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
CMS1_k127_6216212_7	431943.CKL_1616	9.346e-33	144.0	COG4219@1|root,COG4632@1|root,COG4219@2|Bacteria,COG4632@2|Bacteria,1TP3Z@1239|Firmicutes,249NV@186801|Clostridia,36HDP@31979|Clostridiaceae	186801|Clostridia	KT	Peptidase, M56	-	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,NAGPA,Peptidase_M56,Transpeptidase
CMS1_k127_6216212_6	290402.Cbei_0971	1.56e-34	136.0	COG3682@1|root,COG3682@2|Bacteria,1V7EY@1239|Firmicutes,24N11@186801|Clostridia,36J5I@31979|Clostridiaceae	186801|Clostridia	K	Penicillinase repressor	blaI	-	-	ko:K02171	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01504,ko03000	-	-	-	Penicillinase_R
CMS1_k127_6216212_1	665571.STHERM_c15040	1.427e-159	513.0	COG1653@1|root,COG1653@2|Bacteria,2J6W1@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1
CMS1_k127_6216212_4	744872.Spica_1905	2.554e-54	211.0	COG2208@1|root,COG2208@2|Bacteria,2J6MB@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	7TMR-DISM_7TM,SpoIIE
CMS1_k127_6216212_5	1028307.EAE_08400	6.857e-36	153.0	COG4580@1|root,COG4580@2|Bacteria,1MX77@1224|Proteobacteria,1RPMF@1236|Gammaproteobacteria,3X0H0@547|Enterobacter	1236|Gammaproteobacteria	M	Involved in the transport of maltose and maltodextrins	lamB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009279,GO:0009987,GO:0015144,GO:0015159,GO:0015267,GO:0015288,GO:0015774,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0022884,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042956,GO:0042958,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0046930,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098796	-	ko:K02024	-	-	-	-	ko00000,ko02000	1.B.3.1.1	-	iEC55989_1330.EC55989_4527,iYL1228.KPN_04425	LamB
CMS1_k127_6216212_2	929506.CbC4_0084	3.646e-146	471.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36DYU@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	msmX	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
CMS1_k127_6216212_0	1283284.AZUK01000001_gene137	8.109e-242	758.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Alpha amylase catalytic	ams	-	2.4.1.4,3.2.1.1,5.4.99.16	ko:K05341,ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R01823,R02108,R02112,R11262	RC00028,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
CMS1_k127_6227278_2	313590.MED134_05104	1.688e-11	68.0	COG0360@1|root,COG0360@2|Bacteria,4NQ9W@976|Bacteroidetes,1I21M@117743|Flavobacteriia,37F5V@326319|Dokdonia	976|Bacteroidetes	J	Ribosomal protein S6	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
CMS1_k127_6227278_0	497964.CfE428DRAFT_1541	1.309e-32	131.0	COG0629@1|root,COG0629@2|Bacteria,46VGA@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
CMS1_k127_6227278_1	667014.Thein_1689	1.661e-23	104.0	COG0238@1|root,COG0238@2|Bacteria,2GI1A@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
CMS1_k127_6237928_1	255470.cbdbA1673	1.24e-12	75.0	COG3809@1|root,COG3809@2|Bacteria,2GAUV@200795|Chloroflexi,34DEB@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
CMS1_k127_6237928_0	8932.XP_005506280.1	8.133e-20	98.0	COG2030@1|root,2QPX4@2759|Eukaryota,39K2N@33154|Opisthokonta,3BD1Y@33208|Metazoa,3CX6W@33213|Bilateria,4895R@7711|Chordata,494M6@7742|Vertebrata,4GHFQ@8782|Aves	33208|Metazoa	Q	Peroxisomal multifunctional enzyme type 2	HSD17B4	GO:0000003,GO:0000038,GO:0002064,GO:0002119,GO:0002164,GO:0003006,GO:0003674,GO:0003824,GO:0003857,GO:0004303,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0006066,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007548,GO:0007568,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008209,GO:0008210,GO:0008406,GO:0008584,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009719,GO:0009725,GO:0009791,GO:0009888,GO:0009987,GO:0010033,GO:0010817,GO:0010883,GO:0010888,GO:0014070,GO:0016042,GO:0016054,GO:0016125,GO:0016137,GO:0016138,GO:0016229,GO:0016491,GO:0016508,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0018812,GO:0019236,GO:0019395,GO:0019637,GO:0019693,GO:0019748,GO:0019752,GO:0022414,GO:0022611,GO:0030154,GO:0030258,GO:0030283,GO:0030855,GO:0031907,GO:0031974,GO:0032501,GO:0032502,GO:0032787,GO:0032879,GO:0033764,GO:0033865,GO:0033875,GO:0033993,GO:0034032,GO:0034440,GO:0034641,GO:0034754,GO:0035337,GO:0035383,GO:0036111,GO:0036112,GO:0040008,GO:0040024,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0042802,GO:0042803,GO:0042810,GO:0042811,GO:0043053,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0044550,GO:0044594,GO:0045137,GO:0045927,GO:0046395,GO:0046483,GO:0046546,GO:0046661,GO:0046983,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048545,GO:0048580,GO:0048582,GO:0048608,GO:0048638,GO:0048639,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051716,GO:0055086,GO:0055114,GO:0055115,GO:0060008,GO:0060009,GO:0060429,GO:0061062,GO:0061063,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0070887,GO:0071310,GO:0071407,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901568,GO:1901575,GO:1901576,GO:1901615,GO:1901657,GO:1901659,GO:1902652,GO:1904069,GO:1904070,GO:1905952,GO:1905953,GO:2000026	1.1.1.35,4.2.1.107,4.2.1.119	ko:K12405	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R04809,R04810,R04812,R04813,R09698	RC00089,RC00770,RC01217	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas,SCP2,adh_short
CMS1_k127_6238752_1	1121935.AQXX01000052_gene2958	1.345e-27	120.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1RXRJ@1236|Gammaproteobacteria,1XPVP@135619|Oceanospirillales	135619|Oceanospirillales	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
CMS1_k127_6238752_0	1121405.dsmv_2057	2.891e-80	273.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42PYJ@68525|delta/epsilon subdivisions,2WKHY@28221|Deltaproteobacteria,2MJ28@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
CMS1_k127_6238752_2	1191523.MROS_1668	4.478e-19	100.0	2C2F5@1|root,32WND@2|Bacteria	2|Bacteria	-	-	VPA0561	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6238752_3	1293054.HSACCH_00768	1.524e-18	87.0	COG2199@1|root,COG2984@1|root,COG2984@2|Bacteria,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	2.7.7.65	ko:K02488,ko:K21022	ko02020,ko02025,ko04112,map02020,map02025,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,PAS_9
CMS1_k127_6241852_0	509191.AEDB02000076_gene1464	2.023e-135	462.0	COG4412@1|root,COG4412@2|Bacteria,1TTSA@1239|Firmicutes,25BHE@186801|Clostridia,3WGF9@541000|Ruminococcaceae	186801|Clostridia	M	Alpha-1,2-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
CMS1_k127_6241852_1	380703.AHA_0837	3.025e-47	194.0	COG0366@1|root,COG0366@2|Bacteria,1MVQA@1224|Proteobacteria,1RPA4@1236|Gammaproteobacteria,1Y562@135624|Aeromonadales	135624|Aeromonadales	G	Aamy_C	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,PKD
CMS1_k127_6241852_3	5762.XP_002680811.1	0.0003759	49.0	COG0457@1|root,KOG0553@2759|Eukaryota	2759|Eukaryota	O	negative regulation of ER-associated ubiquitin-dependent protein catabolic process	SGTB	GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006457,GO:0006508,GO:0006511,GO:0006605,GO:0006612,GO:0006620,GO:0006807,GO:0006810,GO:0006886,GO:0006950,GO:0006996,GO:0007029,GO:0008022,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009896,GO:0009987,GO:0010033,GO:0010243,GO:0010256,GO:0010498,GO:0010604,GO:0010605,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0019222,GO:0019538,GO:0019941,GO:0030162,GO:0030163,GO:0030433,GO:0030544,GO:0031072,GO:0031323,GO:0031324,GO:0031325,GO:0031329,GO:0031330,GO:0031331,GO:0031333,GO:0032268,GO:0032269,GO:0032270,GO:0032434,GO:0032435,GO:0032436,GO:0032459,GO:0032460,GO:0032947,GO:0032991,GO:0033036,GO:0033365,GO:0033554,GO:0034613,GO:0034976,GO:0036503,GO:0042176,GO:0042177,GO:0042221,GO:0042802,GO:0042803,GO:0042886,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043254,GO:0043621,GO:0043632,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044877,GO:0045047,GO:0045048,GO:0045184,GO:0045732,GO:0045861,GO:0045862,GO:0046907,GO:0046982,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051087,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051205,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051603,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0061024,GO:0061136,GO:0065007,GO:0070727,GO:0070972,GO:0071702,GO:0071704,GO:0071705,GO:0071816,GO:0071840,GO:0072379,GO:0072380,GO:0072594,GO:0072599,GO:0072657,GO:0080090,GO:0080134,GO:0080135,GO:0090150,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901799,GO:1901800,GO:1903050,GO:1903051,GO:1903052,GO:1903069,GO:1903070,GO:1903071,GO:1903332,GO:1903334,GO:1903362,GO:1903363,GO:1903364,GO:1903573,GO:1903644,GO:1903646,GO:1904288,GO:1904292,GO:1904293,GO:1904294,GO:1905897,GO:1905898,GO:2000058,GO:2000059,GO:2000060	-	ko:K16365	-	-	-	-	ko00000,ko04147,ko04516	-	-	-	SGTA_dimer,TPR_1,TPR_11,TPR_2,TPR_8
CMS1_k127_6241852_2	1196322.A370_02335	3.199e-32	131.0	COG0454@1|root,COG0456@2|Bacteria,1VHDN@1239|Firmicutes,24FXK@186801|Clostridia,36WBJ@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
CMS1_k127_6248600_0	1122225.AULQ01000005_gene2483	1.911e-23	102.0	COG4783@1|root,COG4783@2|Bacteria,4NM73@976|Bacteroidetes,1I1R8@117743|Flavobacteriia	976|Bacteroidetes	S	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19
CMS1_k127_6248600_1	521097.Coch_0410	2.222e-21	102.0	2EFR1@1|root,339H3@2|Bacteria,4NWMK@976|Bacteroidetes,1I60N@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6248600_2	620914.JH621252_gene2551	2.366e-12	72.0	2DQ48@1|root,334NI@2|Bacteria,4NWAK@976|Bacteroidetes,1I5WT@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_6248633_0	394.NGR_a02320	1.355e-38	155.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,2U3T3@28211|Alphaproteobacteria,4BJ5C@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
CMS1_k127_6250637_0	1121342.AUCO01000010_gene2315	9.606e-139	452.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,36DHK@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
CMS1_k127_6250637_1	1031288.AXAA01000011_gene610	9.026e-34	137.0	COG1057@1|root,COG1713@1|root,COG1057@2|Bacteria,COG1713@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,36I7Z@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
CMS1_k127_6250637_3	573413.Spirs_1808	3.686e-15	87.0	COG1316@1|root,COG1316@2|Bacteria,2J57I@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
CMS1_k127_6250637_2	935948.KE386494_gene339	1.21e-21	98.0	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,42GYF@68295|Thermoanaerobacterales	186801|Clostridia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
CMS1_k127_6250637_4	717774.Marme_4143	6.513e-05	47.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1XI65@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS,PAS_8
CMS1_k127_6254881_0	177437.HRM2_21730	1.11e-243	764.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria,2MIM6@213118|Desulfobacterales	28221|Deltaproteobacteria	T	5TM C-terminal transporter carbon starvation CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
CMS1_k127_6254881_1	1121324.CLIT_11c01700	1.22e-06	57.0	COG0484@1|root,COG0484@2|Bacteria,1TS44@1239|Firmicutes,24A9N@186801|Clostridia,25UFC@186804|Peptostreptococcaceae	186801|Clostridia	O	DnaJ molecular chaperone homology domain	CbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
CMS1_k127_6255896_1	521011.Mpal_0141	5.428e-52	211.0	COG0642@1|root,COG2203@1|root,arCOG02385@1|root,arCOG02357@2157|Archaea,arCOG02385@2157|Archaea,arCOG06192@2157|Archaea,2Y7UU@28890|Euryarchaeota,2NANW@224756|Methanomicrobia	224756|Methanomicrobia	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2
CMS1_k127_6255896_0	391612.CY0110_25716	5.066e-101	366.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,3KH9M@43988|Cyanothece	1117|Cyanobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,Response_reg,dCache_1
CMS1_k127_6259570_0	889378.Spiaf_2521	2.044e-164	560.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	malS	-	2.1.1.72,3.1.4.46,3.2.1.1	ko:K00571,ko:K01126,ko:K01176	ko00500,ko00564,ko01100,ko04973,map00500,map00564,map01100,map04973	-	R01030,R01470,R02108,R02112,R11262	RC00017,RC00425	ko00000,ko00001,ko01000,ko02048	-	GH13	-	Alpha-amylase,CBM26
CMS1_k127_6259570_1	1321778.HMPREF1982_04107	4.167e-48	183.0	COG1378@1|root,COG1378@2|Bacteria	2|Bacteria	K	Sugar-specific transcriptional regulator TrmB	yrhO1	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
CMS1_k127_6260666_1	754027.HMPREF9554_01175	2.33e-26	116.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
CMS1_k127_6260666_0	589865.DaAHT2_0593	1.054e-73	280.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1R8QH@1224|Proteobacteria,42T02@68525|delta/epsilon subdivisions,2WPNU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	PFAM WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
CMS1_k127_6264960_2	748449.Halha_0821	6.97e-60	227.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WA8B@53433|Halanaerobiales	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
CMS1_k127_6264960_1	1158338.JNLJ01000005_gene1436	1.02e-61	220.0	COG0745@1|root,COG0745@2|Bacteria,2G4UZ@200783|Aquificae	200783|Aquificae	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07657,ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
CMS1_k127_6264960_3	330214.NIDE2416	1.428e-39	155.0	COG0704@1|root,COG0704@2|Bacteria,3J0M6@40117|Nitrospirae	40117|Nitrospirae	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
CMS1_k127_6264960_0	1121887.AUDK01000009_gene1301	2.952e-114	372.0	COG1117@1|root,COG1117@2|Bacteria,4NFAB@976|Bacteroidetes,1HZHC@117743|Flavobacteriia,2NSSM@237|Flavobacterium	976|Bacteroidetes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
CMS1_k127_6277909_5	744872.Spica_0364	2.58e-08	64.0	COG0457@1|root,COG0457@2|Bacteria,2J5RJ@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
CMS1_k127_6277909_0	717231.Flexsi_1202	2.703e-125	421.0	COG1283@1|root,COG1283@2|Bacteria,2GEY7@200930|Deferribacteres	200930|Deferribacteres	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
CMS1_k127_6277909_4	411459.RUMOBE_00006	1.063e-44	165.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,3Y045@572511|Blautia	186801|Clostridia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
CMS1_k127_6277909_2	273068.TTE2257	5.861e-56	199.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,42GCE@68295|Thermoanaerobacterales	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
CMS1_k127_6277909_1	177437.HRM2_33390	7.22e-116	384.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,2MHYS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
CMS1_k127_6277909_3	1122947.FR7_3954	2.82e-47	186.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,4H2Y6@909932|Negativicutes	909932|Negativicutes	O	cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
CMS1_k127_627835_2	573413.Spirs_1737	3.128e-08	55.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
CMS1_k127_627835_1	759914.BP951000_2121	1.12e-55	209.0	COG0664@1|root,COG1729@1|root,COG0664@2|Bacteria,COG1729@2|Bacteria,2J5MQ@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8,cNMP_binding
CMS1_k127_627835_0	744872.Spica_0771	1.289e-88	306.0	COG0402@1|root,COG0402@2|Bacteria,2J6KS@203691|Spirochaetes	203691|Spirochaetes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
CMS1_k127_634119_3	580331.Thit_2380	1.333e-32	132.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia,42GRT@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
CMS1_k127_634119_0	635013.TherJR_2972	1.038e-133	439.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,260E3@186807|Peptococcaceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
CMS1_k127_634119_4	483219.LILAB_24815	1.124e-26	119.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2YV69@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
CMS1_k127_634119_2	1347392.CCEZ01000074_gene1896	2.016e-33	138.0	COG0500@1|root,COG2226@2|Bacteria,1TQUF@1239|Firmicutes,25E3F@186801|Clostridia,36UHC@31979|Clostridiaceae	186801|Clostridia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
CMS1_k127_634119_1	485916.Dtox_3625	5.107e-92	312.0	COG1775@1|root,COG1775@2|Bacteria,1TSHM@1239|Firmicutes,249WE@186801|Clostridia,26023@186807|Peptococcaceae	186801|Clostridia	E	PFAM 2-hydroxyglutaryl-CoA dehydratase D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
CMS1_k127_634119_5	760192.Halhy_0047	0.0001282	46.0	2EM0F@1|root,33EPY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_638091_3	944479.JQLX01000012_gene1090	1.794e-62	236.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2M6UC@213113|Desulfurellales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
CMS1_k127_638091_0	857293.CAAU_2072	2.811e-143	463.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36DYU@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	msmX	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
CMS1_k127_638091_1	1031288.AXAA01000030_gene245	1.153e-135	444.0	COG0366@1|root,COG0366@2|Bacteria,1U7JS@1239|Firmicutes,24ATB@186801|Clostridia,36HBW@31979|Clostridiaceae	186801|Clostridia	G	Glycogen debranching enzyme, glucanotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
CMS1_k127_638091_2	1319815.HMPREF0202_00126	5.867e-95	319.0	COG3833@1|root,COG3833@2|Bacteria,37C67@32066|Fusobacteria	32066|Fusobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
CMS1_k127_638091_4	1319815.HMPREF0202_00127	2.812e-28	116.0	COG1175@1|root,COG1175@2|Bacteria,37C9U@32066|Fusobacteria	32066|Fusobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
CMS1_k127_652172_1	153721.MYP_3209	1.863e-107	381.0	COG4412@1|root,COG4412@2|Bacteria,4NF4S@976|Bacteroidetes,47R9E@768503|Cytophagia	976|Bacteroidetes	S	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_652172_3	926561.KB900617_gene1358	4.137e-54	217.0	COG0366@1|root,COG1974@1|root,COG0366@2|Bacteria,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,HTH_3,PKD,Peptidase_S24,SLH
CMS1_k127_652172_4	443254.Marpi_0543	4.504e-14	87.0	COG0366@1|root,COG0366@2|Bacteria,2GDTX@200918|Thermotogae	200918|Thermotogae	G	PFAM alpha amylase, catalytic	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
CMS1_k127_652172_2	1158294.JOMI01000009_gene862	2.612e-95	323.0	COG0535@1|root,COG0535@2|Bacteria,4NHXT@976|Bacteroidetes,2FN32@200643|Bacteroidia	976|Bacteroidetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
CMS1_k127_652172_6	1117319.PSPO_19911	1.522e-06	55.0	COG3279@1|root,COG3279@2|Bacteria,1NBJ0@1224|Proteobacteria,1SG0W@1236|Gammaproteobacteria,2Q3AG@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	KT	COG3279 Response regulator of the LytR AlgR family	-	-	-	-	-	-	-	-	-	-	-	-	LytTR
CMS1_k127_652172_0	572544.Ilyop_0439	4.417e-170	553.0	COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,379S8@32066|Fusobacteria	32066|Fusobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
CMS1_k127_653010_0	395493.BegalDRAFT_1112	8.28e-70	256.0	COG0642@1|root,COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T4BF@1236|Gammaproteobacteria	1224|Proteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	chiS	-	2.7.13.3	ko:K07711,ko:K19694	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HTH_18,HisKA,PAS,PAS_3,PAS_4,PAS_8,Response_reg,Y_Y_Y
CMS1_k127_659948_0	937774.TEQUI_0062	8.933e-27	115.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2VSCK@28216|Betaproteobacteria,3T4GB@506|Alcaligenaceae	28216|Betaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
CMS1_k127_659948_1	945713.IALB_2930	1.295e-15	89.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_66437_1	1379698.RBG1_1C00001G1333	1.787e-45	182.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2NP51@2323|unclassified Bacteria	2|Bacteria	KT	Sigma factor PP2C-like phosphatases	pkn5	-	2.7.11.1,3.1.3.3	ko:K04757,ko:K07315	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	AAA_16,GAF,HAMP,HATPase_c_2,Pkinase,SpoIIE,dCache_1
CMS1_k127_66437_0	768670.Calni_0774	6.385e-52	195.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2GF2A@200930|Deferribacteres	200930|Deferribacteres	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
CMS1_k127_677575_0	439292.Bsel_2967	7.883e-74	271.0	COG0286@1|root,COG0286@2|Bacteria,1UMSN@1239|Firmicutes,4IT1W@91061|Bacilli,26PG5@186821|Sporolactobacillaceae	91061|Bacilli	L	TaqI-like C-terminal specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,N6_Mtase,TaqI_C
CMS1_k127_679272_0	1125863.JAFN01000001_gene1191	2.164e-60	228.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	mcp40H-5	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_2,sCache_2
CMS1_k127_685124_3	1499967.BAYZ01000033_gene1088	5.213e-14	76.0	COG0116@1|root,COG0116@2|Bacteria	2|Bacteria	L	23S rRNA (guanine(2445)-N(2))-methyltransferase activity	rlmL	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
CMS1_k127_685124_0	1242864.D187_000187	4.187e-163	524.0	COG0366@1|root,COG0366@2|Bacteria,1MX9V@1224|Proteobacteria,4316S@68525|delta/epsilon subdivisions,2WWX2@28221|Deltaproteobacteria,2YWTT@29|Myxococcales	28221|Deltaproteobacteria	G	Alpha-amylase C-terminal beta-sheet domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amyl_C2,Alpha-amylase
CMS1_k127_685124_1	926561.KB900617_gene1423	7.097e-116	380.0	COG0524@1|root,COG0524@2|Bacteria,1TRRQ@1239|Firmicutes,258PD@186801|Clostridia,3WC27@53433|Halanaerobiales	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
CMS1_k127_685124_2	926561.KB900622_gene465	2.577e-57	206.0	2DBP0@1|root,2ZA6P@2|Bacteria,1V58E@1239|Firmicutes,24GG5@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_71610_2	572480.Arnit_2801	6.366e-26	110.0	COG1846@1|root,COG1846@2|Bacteria,1N95Z@1224|Proteobacteria,42V7I@68525|delta/epsilon subdivisions,2YQ3T@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	PFAM regulatory protein MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS1_k127_71610_1	153496.JNAB01000007_gene2666	1.085e-26	117.0	COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2U63R@28211|Alphaproteobacteria,2JSDE@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
CMS1_k127_71610_0	1379698.RBG1_1C00001G0684	2.439e-126	420.0	COG0277@1|root,COG0277@2|Bacteria,2NP1E@2323|unclassified Bacteria	2|Bacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104,ko:K18930	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
CMS1_k127_71610_3	765869.BDW_09790	3.708e-08	66.0	COG0664@1|root,COG0664@2|Bacteria,1QQU0@1224|Proteobacteria,43EX1@68525|delta/epsilon subdivisions,2MU4N@213481|Bdellovibrionales,2X2F8@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	Hyperpolarization-activated, cyclic nucleotide-gated K	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
CMS1_k127_71610_4	1347342.BN863_12400	2.584e-07	64.0	COG2339@1|root,COG2339@2|Bacteria,4NGUS@976|Bacteroidetes,1HY3J@117743|Flavobacteriia	976|Bacteroidetes	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
CMS1_k127_73520_1	1123511.KB905864_gene2576	2.297e-106	354.0	COG1454@1|root,COG1454@2|Bacteria,1UGWW@1239|Firmicutes,4H71M@909932|Negativicutes	909932|Negativicutes	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
CMS1_k127_73520_0	1121904.ARBP01000026_gene619	1.203e-227	719.0	COG0513@1|root,COG0513@2|Bacteria,4NEJV@976|Bacteroidetes,47KSE@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the DEAD box helicase family	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
CMS1_k127_73520_2	313606.M23134_01691	2.009e-93	323.0	COG0464@1|root,COG0464@2|Bacteria,4NH44@976|Bacteroidetes,47RMN@768503|Cytophagia	976|Bacteroidetes	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
CMS1_k127_777130_0	2340.JV46_20590	6.721e-88	303.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T1YP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,SBP_bac_3
CMS1_k127_777130_1	1196324.A374_19100	1.68e-58	209.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1TQX3@1239|Firmicutes,4HCI6@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
CMS1_k127_821966_0	443144.GM21_3765	3.622e-234	741.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,43UAC@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB-2	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
CMS1_k127_851111_7	997346.HMPREF9374_1494	5.508e-52	190.0	COG0558@1|root,COG0558@2|Bacteria,1V50T@1239|Firmicutes,4HH51@91061|Bacilli,27CU1@186824|Thermoactinomycetaceae	91061|Bacilli	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
CMS1_k127_851111_2	469617.FUAG_00266	1.346e-112	375.0	COG1752@1|root,COG1752@2|Bacteria,37BU3@32066|Fusobacteria	32066|Fusobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
CMS1_k127_851111_6	688270.Celal_3813	4.977e-70	245.0	COG4221@1|root,COG4221@2|Bacteria,4PAHX@976|Bacteroidetes,1IM5I@117743|Flavobacteriia,1FA6D@104264|Cellulophaga	976|Bacteroidetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
CMS1_k127_851111_3	469617.FUAG_00268	1.232e-95	328.0	COG0671@1|root,COG2453@1|root,COG0671@2|Bacteria,COG2453@2|Bacteria,37A3H@32066|Fusobacteria	32066|Fusobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PAP2_3
CMS1_k127_851111_0	338963.Pcar_2780	5.473e-205	654.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM alpha beta hydrolase fold	agmH	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
CMS1_k127_851111_1	1122599.AUGR01000015_gene2694	7.773e-118	387.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,1RRAG@1236|Gammaproteobacteria,1XNNH@135619|Oceanospirillales	135619|Oceanospirillales	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
CMS1_k127_851111_8	1280692.AUJL01000008_gene2362	1.716e-08	58.0	COG0789@1|root,COG0789@2|Bacteria,1VEB9@1239|Firmicutes,249NR@186801|Clostridia,36DBZ@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
CMS1_k127_851111_4	1121930.AQXG01000015_gene1869	2.506e-89	307.0	COG3424@1|root,COG3424@2|Bacteria,4NDZU@976|Bacteroidetes,1IRE8@117747|Sphingobacteriia	976|Bacteroidetes	Q	PFAM Chalcone and stilbene synthases, N-terminal domain	bcsA	-	-	-	-	-	-	-	-	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N,FAE1_CUT1_RppA
CMS1_k127_851111_5	1034943.BN1094_00524	1.441e-78	268.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.95	ko:K05928	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00112	R07236,R07504,R10491,R10492	RC00003,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	CMAS,Methyltransf_11
CMS1_k127_855821_1	706436.HMPREF9074_08450	8.595e-40	152.0	COG1196@1|root,COG1196@2|Bacteria,4NQFT@976|Bacteroidetes,1I9I1@117743|Flavobacteriia,1ESHG@1016|Capnocytophaga	976|Bacteroidetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21,AAA_23
CMS1_k127_855821_2	521045.Kole_1961	4.023e-08	57.0	COG3620@1|root,COG3620@2|Bacteria,2GDQP@200918|Thermotogae	200918|Thermotogae	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_855821_0	269799.Gmet_2422	2.921e-118	414.0	COG0840@1|root,COG2770@1|root,COG3829@1|root,COG0840@2|Bacteria,COG2770@2|Bacteria,COG3829@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,43STW@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	mcp34H-7	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CZB,HAMP,MCPsignal,PAS_4,dCache_1
CMS1_k127_867814_5	1121904.ARBP01000003_gene6447	1.872e-39	153.0	COG1988@1|root,COG1988@2|Bacteria,4NPMW@976|Bacteroidetes,47VIF@768503|Cytophagia	976|Bacteroidetes	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
CMS1_k127_867814_15	1195236.CTER_0736	1.518e-12	72.0	2ED6C@1|root,33731@2|Bacteria,1VHBA@1239|Firmicutes,24IAN@186801|Clostridia,3WR9V@541000|Ruminococcaceae	186801|Clostridia	S	Family of unknown function (DUF5362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5362
CMS1_k127_867814_11	443143.GM18_2527	2.372e-28	132.0	COG0591@1|root,COG2203@1|root,COG2208@1|root,COG0591@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1QTSW@1224|Proteobacteria,43AQ6@68525|delta/epsilon subdivisions,2X63Z@28221|Deltaproteobacteria,43W3H@69541|Desulfuromonadales	28221|Deltaproteobacteria	EKT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SpoIIE
CMS1_k127_867814_2	37659.JNLN01000001_gene1280	3.155e-55	217.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EVU@31979|Clostridiaceae	186801|Clostridia	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
CMS1_k127_867814_4	643648.Slip_1523	5.455e-42	169.0	COG0457@1|root,COG3359@1|root,COG0457@2|Bacteria,COG3359@2|Bacteria,1TQQU@1239|Firmicutes	1239|Firmicutes	L	Exonuclease	yprB	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
CMS1_k127_867814_0	1379698.RBG1_1C00001G1048	1.638e-262	829.0	COG1205@1|root,COG1205@2|Bacteria,2NNKJ@2323|unclassified Bacteria	2|Bacteria	L	Domain of unknown function (DUF1998)	yprA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
CMS1_k127_867814_8	1408312.JNJS01000001_gene1248	2.492e-32	144.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,3NHVI@46205|Pseudobutyrivibrio	186801|Clostridia	NT	HAMP domain	-	-	-	-	-	-	-	-	-	-	-	-	MCPsignal,dCache_1
CMS1_k127_867814_10	340177.Cag_1554	7.873e-30	120.0	2DNFB@1|root,32X7Q@2|Bacteria,1FE3W@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_867814_6	1444712.BN1013_00169	2.834e-35	139.0	COG1762@1|root,COG1762@2|Bacteria,2JG5P@204428|Chlamydiae	204428|Chlamydiae	G	PTS system, IIa	ptsN_1	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
CMS1_k127_867814_1	158190.SpiGrapes_2308	7.239e-100	339.0	COG0475@1|root,COG0475@2|Bacteria,2J5WC@203691|Spirochaetes	203691|Spirochaetes	P	Sodium hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Na_H_Exchanger
CMS1_k127_867814_17	1480694.DC28_10425	2.453e-06	53.0	29AXJ@1|root,2ZXWN@2|Bacteria,2JBAS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_867814_18	1220534.B655_0330	4.851e-05	54.0	COG5635@1|root,arCOG06468@1|root,arCOG02967@2157|Archaea,arCOG06468@2157|Archaea,2Y7N5@28890|Euryarchaeota	28890|Euryarchaeota	T	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	ko:K22221	-	-	-	-	ko00000	-	-	-	HEAT_2,HEAT_PBS,NACHT
CMS1_k127_867814_14	1408322.JHYK01000032_gene98	9.865e-14	84.0	COG0642@1|root,COG0784@1|root,COG3437@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,27I9U@186928|unclassified Lachnospiraceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DegV,HATPase_c,HD,HisKA,HisKA_7TM,Hpt,MASE3,Response_reg
CMS1_k127_867814_9	118005.AWNK01000007_gene805	2.119e-30	138.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_9,RsbU_N,SpoIIE
CMS1_k127_867814_12	1279017.AQYJ01000017_gene1412	5.155e-15	78.0	2DSCF@1|root,33FHP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_867814_7	439235.Dalk_4719	1.47e-33	134.0	COG1846@1|root,COG1846@2|Bacteria,1N244@1224|Proteobacteria,42TYY@68525|delta/epsilon subdivisions,2WQP5@28221|Deltaproteobacteria,2MM6Y@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
CMS1_k127_867814_3	1304885.AUEY01000012_gene1777	9.371e-47	174.0	COG0500@1|root,COG2226@2|Bacteria,1N3WC@1224|Proteobacteria,42URQ@68525|delta/epsilon subdivisions,2WQGW@28221|Deltaproteobacteria,2MKH6@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	FtsJ-like methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
CMS1_k127_867814_16	398767.Glov_2106	3.149e-12	67.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2WIXY@28221|Deltaproteobacteria,43RZ8@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	AIR synthase related protein domain protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1844	AIRS,AIRS_C
CMS1_k127_871303_0	1307761.L21SP2_2378	4.916e-155	505.0	COG1960@1|root,COG1960@2|Bacteria,2J5X1@203691|Spirochaetes	203691|Spirochaetes	C	Acyl-CoA dehydrogenase, C-terminal domain	fadE	-	-	ko:K15980	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin
CMS1_k127_871303_2	1046714.AMRX01000007_gene2252	2.002e-110	362.0	COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,4681Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Haloacid dehalogenase-like hydrolase	nagD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.41	ko:K01101,ko:K02566	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
CMS1_k127_871303_1	1313304.CALK_1401	2.848e-125	409.0	COG0371@1|root,COG0371@2|Bacteria	2|Bacteria	C	Dehydrogenase	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
CMS1_k127_871303_3	204669.Acid345_2946	9.171e-35	149.0	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,3Y56X@57723|Acidobacteria,2JM0P@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
CMS1_k127_872501_2	1462526.BN990_03811	2.359e-50	188.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli,4C50V@84406|Virgibacillus	91061|Bacilli	J	RNA 2'-O ribose methyltransferase substrate binding	trmH	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
CMS1_k127_872501_0	1047013.AQSP01000045_gene110	6.529e-141	462.0	COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905,iNJ661.Rv2130c	DALR_2,tRNA-synt_1e,tRNA-synt_1g
CMS1_k127_872501_1	1118054.CAGW01000061_gene2363	8.53e-51	193.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26TIQ@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	gsiB_3	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
CMS1_k127_876113_1	665571.STHERM_c04790	1.478e-35	149.0	2B518@1|root,31XUG@2|Bacteria,2JAMI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_876113_0	439235.Dalk_3434	0.0	1053.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
CMS1_k127_888171_4	522772.Dacet_2986	3.992e-52	188.0	COG0569@1|root,COG0569@2|Bacteria,2GF6N@200930|Deferribacteres	200930|Deferribacteres	C	Putative NAD(P)-binding	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
CMS1_k127_888171_2	720554.Clocl_2908	4.047e-64	223.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,3WK3U@541000|Ruminococcaceae	186801|Clostridia	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
CMS1_k127_888171_0	1201288.M900_1378	5.669e-95	322.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,42QEX@68525|delta/epsilon subdivisions,2MSY0@213481|Bdellovibrionales,2WMFU@28221|Deltaproteobacteria	213481|Bdellovibrionales	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
CMS1_k127_888171_3	264462.Bd2569	1.291e-62	222.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42QU4@68525|delta/epsilon subdivisions,2MT0Z@213481|Bdellovibrionales,2WMRQ@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	peptidylprolyl isomerase, FKBP-type	-	-	5.2.1.8	ko:K01802,ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	iAF987.Gmet_2161	FKBP_C,FKBP_N
CMS1_k127_888171_1	706587.Desti_2310	2.333e-71	244.0	COG0652@1|root,COG0652@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2X5NA@28221|Deltaproteobacteria,2MRM6@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
CMS1_k127_888171_6	572544.Ilyop_0652	6.868e-37	146.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
CMS1_k127_888171_5	1519464.HY22_13100	3.654e-50	189.0	COG2114@1|root,COG2114@2|Bacteria,1FFF9@1090|Chlorobi	1090|Chlorobi	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
CMS1_k127_897019_0	1379698.RBG1_1C00001G0402	6.801e-165	542.0	COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria	2|Bacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
CMS1_k127_918698_0	1121904.ARBP01000021_gene3574	5.924e-40	166.0	COG1626@1|root,COG1626@2|Bacteria,4PKJT@976|Bacteroidetes	976|Bacteroidetes	G	glycoside hydrolase family 37	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63,Trehalase
CMS1_k127_923568_0	1291050.JAGE01000001_gene2969	6.243e-08	61.0	COG1595@1|root,COG1595@2|Bacteria,1V4B8@1239|Firmicutes,24KEK@186801|Clostridia,3WM37@541000|Ruminococcaceae	186801|Clostridia	K	Sigma-70, region 4	sigK_1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_923778_0	573413.Spirs_0282	1.43e-26	124.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
CMS1_k127_923778_1	1268239.PALB_36720	2.994e-21	100.0	COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,1S41X@1236|Gammaproteobacteria,2Q0E4@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
CMS1_k127_925560_0	439235.Dalk_0572	8.461e-116	402.0	COG0745@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MI2B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
CMS1_k127_931115_0	1122915.AUGY01000097_gene3688	7.789e-06	49.0	COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,4HBZE@91061|Bacilli,26RI4@186822|Paenibacillaceae	91061|Bacilli	M	COG3209 Rhs family protein	wapA	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0004549,GO:0006139,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016078,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	RHS_repeat
CMS1_k127_943251_2	1232437.KL661955_gene2368	3.406e-22	109.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42P90@68525|delta/epsilon subdivisions,2WK8R@28221|Deltaproteobacteria,2MI3H@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
CMS1_k127_943251_3	153721.MYP_4532	7.853e-20	93.0	COG0792@1|root,COG0792@2|Bacteria,4NS7E@976|Bacteroidetes,47QW9@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
CMS1_k127_943251_0	1307761.L21SP2_1747	1.362e-61	226.0	COG2206@1|root,COG2206@2|Bacteria,2J6GF@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
CMS1_k127_943251_4	580331.Thit_1436	1.836e-11	68.0	COG2257@1|root,COG2257@2|Bacteria,1VF4R@1239|Firmicutes,24QSW@186801|Clostridia,42H7Z@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM type III secretion exporter	flhB1	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
CMS1_k127_943251_1	706587.Desti_0101	9.729e-41	155.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2WNK2@28221|Deltaproteobacteria,2MRVP@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF208,RNase_HII
CMS1_k127_950277_2	1499967.BAYZ01000155_gene641	6.084e-47	181.0	COG1175@1|root,COG1175@2|Bacteria,2NPDA@2323|unclassified Bacteria	2|Bacteria	G	binding-protein-dependent transport systems inner membrane component	amyD	-	-	ko:K02025,ko:K10118,ko:K15771	ko02010,map02010	M00196,M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.28	-	-	BPD_transp_1
CMS1_k127_950277_1	561177.ANHYDRO_01254	2.946e-118	392.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,22GAB@1570339|Peptoniphilaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010,ko:K10112	ko02010,map02010	M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10	-	-	ABC_tran,TOBE,TOBE_2
CMS1_k127_950277_0	547144.HydHO_0604	6.702e-179	579.0	COG0296@1|root,COG0296@2|Bacteria	2|Bacteria	G	1,4-alpha-glucan branching enzyme activity	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
CMS1_k127_96206_2	515635.Dtur_1217	1.434e-31	139.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	GAF,GAF_2,GAF_3,HAMP,HD,HD_5,Response_reg
CMS1_k127_96206_3	373994.Riv7116_1988	9.424e-20	103.0	COG4191@1|root,COG4191@2|Bacteria,1G5E0@1117|Cyanobacteria	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
CMS1_k127_96206_0	880073.Calab_0698	2.506e-78	283.0	COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	zraR	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
CMS1_k127_96206_1	690850.Desaf_2287	1.23e-49	188.0	COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,42QVG@68525|delta/epsilon subdivisions,2WNKA@28221|Deltaproteobacteria,2M9AG@213115|Desulfovibrionales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS1_k127_966049_4	990073.ATHU01000001_gene251	6.363e-47	173.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2YM8M@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
CMS1_k127_966049_3	555779.Dthio_PD1098	5.438e-64	226.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria,2M883@213115|Desulfovibrionales	28221|Deltaproteobacteria	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
CMS1_k127_966049_7	311424.DhcVS_1212	2.575e-20	94.0	COG0375@1|root,COG0375@2|Bacteria,2G77T@200795|Chloroflexi,34DD7@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
CMS1_k127_966049_5	1499967.BAYZ01000050_gene2790	1.273e-45	169.0	2ABIE@1|root,310ZN@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
CMS1_k127_966049_1	1121342.AUCO01000015_gene2713	3.552e-88	301.0	COG2378@1|root,COG2378@2|Bacteria,1TT23@1239|Firmicutes,248A8@186801|Clostridia,36WR0@31979|Clostridiaceae	186801|Clostridia	K	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
CMS1_k127_966049_2	645991.Sgly_3228	4.377e-68	237.0	COG0494@1|root,COG0494@2|Bacteria,1V6SF@1239|Firmicutes,24HCG@186801|Clostridia,261VE@186807|Peptococcaceae	186801|Clostridia	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
CMS1_k127_966049_6	742765.HMPREF9457_00466	6.622e-32	128.0	COG0599@1|root,COG0599@2|Bacteria,1UWS5@1239|Firmicutes,24J92@186801|Clostridia,27WVP@189330|Dorea	186801|Clostridia	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
CMS1_k127_966049_0	388413.ALPR1_14814	9.548e-114	377.0	COG0535@1|root,COG0535@2|Bacteria,4NFRX@976|Bacteroidetes,47KUF@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
CMS1_k127_966049_9	764291.STRUR_1974	1.141e-09	64.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,4HM8Q@91061|Bacilli	91061|Bacilli	K	Transcriptional regulator	ansR	-	-	-	-	-	-	-	-	-	-	-	HTH_3
CMS1_k127_966049_8	96561.Dole_2865	1.879e-10	67.0	2E6UZ@1|root,331EN@2|Bacteria,1NDI7@1224|Proteobacteria,42W7T@68525|delta/epsilon subdivisions,2WS5H@28221|Deltaproteobacteria,2MM0D@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_972867_1	926561.KB900617_gene1358	1.618e-38	168.0	COG0366@1|root,COG1974@1|root,COG0366@2|Bacteria,COG1974@2|Bacteria	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,HTH_3,PKD,Peptidase_S24,SLH
CMS1_k127_972867_2	1123320.KB889561_gene4759	0.0001055	57.0	COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria	201174|Actinobacteria	M	PFAM peptidase M6, immune inhibitor A	-	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M6
CMS1_k127_972867_0	997884.HMPREF1068_04218	1.093e-54	222.0	COG4870@1|root,COG4870@2|Bacteria,4NKEE@976|Bacteroidetes,2FRKR@200643|Bacteroidia	976|Bacteroidetes	O	Belongs to the peptidase C1 family	-	-	-	-	-	-	-	-	-	-	-	-	-
CMS1_k127_976734_0	335543.Sfum_1411	6.297e-153	497.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,2MQ6I@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
CMS1_k127_989680_0	452637.Oter_0326	1.808e-06	57.0	COG1595@1|root,COG1595@2|Bacteria,46VS5@74201|Verrucomicrobia,3K8B3@414999|Opitutae	414999|Opitutae	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
CMS1_k127_990753_0	373903.Hore_09660	1.61e-261	860.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
CMS1_k127_990753_2	373903.Hore_09670	6.461e-147	493.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
CMS1_k127_990753_1	290315.Clim_2319	6.723e-164	533.0	COG0119@1|root,COG0119@2|Bacteria,1FEPR@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
CMS1_k127_990753_3	1121930.AQXG01000014_gene350	3.725e-15	85.0	COG1404@1|root,COG2356@1|root,COG3291@1|root,COG1404@2|Bacteria,COG2356@2|Bacteria,COG3291@2|Bacteria,4PI1X@976|Bacteroidetes,1IXYZ@117747|Sphingobacteriia	976|Bacteroidetes	L	Endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1
CMS1_k127_997195_2	1121957.ATVL01000012_gene777	4.071e-27	120.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	yyaM	-	-	-	-	-	-	-	-	-	-	-	EamA
CMS1_k127_997195_0	1121904.ARBP01000009_gene4293	7.109e-112	367.0	COG3000@1|root,COG3000@2|Bacteria,4NES7@976|Bacteroidetes,47JFN@768503|Cytophagia	976|Bacteroidetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
CMS1_k127_997195_4	1123278.KB893587_gene552	4.78e-05	49.0	COG4980@1|root,COG4980@2|Bacteria,4NR7R@976|Bacteroidetes,47QX5@768503|Cytophagia	976|Bacteroidetes	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
CMS1_k127_997195_1	1122176.KB903531_gene2809	4.301e-98	327.0	COG0412@1|root,COG0412@2|Bacteria,4NKMA@976|Bacteroidetes,1IV93@117747|Sphingobacteriia	976|Bacteroidetes	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	DLH
CMS1_k127_997195_3	1237149.C900_04190	8.698e-08	55.0	COG0457@1|root,COG0457@2|Bacteria,4NFHT@976|Bacteroidetes,47PQF@768503|Cytophagia	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
CMS1_k127_997611_2	747365.Thena_1152	5.027e-132	429.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia,42EZ9@68295|Thermoanaerobacterales	186801|Clostridia	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
CMS1_k127_997611_5	747365.Thena_1151	8.815e-42	156.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,42GQB@68295|Thermoanaerobacterales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
CMS1_k127_997611_1	443144.GM21_0391	4.495e-151	489.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,42MQ1@68525|delta/epsilon subdivisions,2WJII@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
CMS1_k127_997611_0	747365.Thena_1149	3.256e-191	608.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,42FHX@68295|Thermoanaerobacterales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
CMS1_k127_997611_4	243231.GSU0379	3.096e-57	209.0	COG0095@1|root,COG0095@2|Bacteria,1RI3T@1224|Proteobacteria,42SQP@68525|delta/epsilon subdivisions,2WQH2@28221|Deltaproteobacteria,43SNR@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Biotin/lipoate A/B protein ligase family	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
CMS1_k127_997611_3	269799.Gmet_3150	4.752e-103	342.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,42P2E@68525|delta/epsilon subdivisions,2WIJQ@28221|Deltaproteobacteria,43TBK@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
## 2866 queries scanned
## Total time (seconds): 73.11413717269897
## Rate: 39.20 q/s