## Fri Nov 8 13:07:42 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS2_bin.1.fa -m mmseqs --itype genome -o CMS2_bin.1 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS2_bin.1 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs CMS2_k127_1011427_4 379066.GAU_2377 4.539e-111 377.0 COG0265@1|root,COG0265@2|Bacteria,1ZTG6@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS2_k127_1011427_0 861299.J421_3848 1.237e-311 966.0 COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 CMS2_k127_1011427_8 404589.Anae109_1579 2.344e-77 266.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2YVSU@29|Myxococcales 28221|Deltaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid CMS2_k127_1011427_10 1118054.CAGW01000017_gene4422 4.996e-61 219.0 COG0274@1|root,COG1051@1|root,COG0274@2|Bacteria,COG1051@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,26QH3@186822|Paenibacillaceae 91061|Bacilli F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - iSB619.SA_RS00835,iYO844.BSU39420 DeoC CMS2_k127_1011427_11 187272.Mlg_1738 5.785e-24 110.0 COG0704@1|root,COG0704@2|Bacteria,1NRGK@1224|Proteobacteria,1SMQP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PhoU domain - - - - - - - - - - - - PhoU CMS2_k127_1011427_9 290512.Paes_1607 4.459e-77 272.0 COG1283@1|root,COG1283@2|Bacteria,1FEHC@1090|Chlorobi 1090|Chlorobi P Na+/Pi-cotransporter - - - ko:K14683 - - - - ko00000,ko02000,ko04147 2.A.58.1 - - Na_Pi_cotrans CMS2_k127_1011427_6 379066.GAU_2360 4.193e-87 310.0 COG5002@1|root,COG5002@2|Bacteria,1ZT2H@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA CMS2_k127_1011427_5 379066.GAU_2359 1.755e-92 309.0 COG0745@1|root,COG0745@2|Bacteria,1ZTC6@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C CMS2_k127_1011427_1 309807.SRU_0271 1.851e-160 521.0 COG1409@1|root,COG1409@2|Bacteria,4NF9K@976|Bacteroidetes 976|Bacteroidetes C PFAM Calcineurin-like phosphoesterase - - - - - - - - - - - - DUF4985,GHL10,Metallophos,MetallophosC,MetallophosN CMS2_k127_1011427_3 1379270.AUXF01000003_gene3570 2.359e-112 393.0 COG0737@1|root,COG0737@2|Bacteria,1ZTEA@142182|Gemmatimonadetes 142182|Gemmatimonadetes F 5'-nucleotidase, C-terminal domain - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos CMS2_k127_1011427_2 935863.AWZR01000007_gene223 8.59e-131 432.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,1X3AE@135614|Xanthomonadales 135614|Xanthomonadales F Na dependent nucleoside transporter yeiM - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N CMS2_k127_1011427_7 1341151.ASZU01000003_gene2690 7.646e-79 274.0 COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,27BBV@186824|Thermoactinomycetaceae 91061|Bacilli F Phosphorylase superfamily punA - 2.4.2.1,2.4.2.28 ko:K00772,ko:K03783 ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 M00034 R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 CMS2_k127_1023465_7 379066.GAU_1355 9.206e-13 75.0 COG1629@1|root,COG1629@2|Bacteria 2|Bacteria P transport - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_1023465_6 1122621.ATZA01000027_gene2494 1.29e-53 194.0 COG1443@1|root,COG1443@2|Bacteria,4NFJV@976|Bacteroidetes,1ISDP@117747|Sphingobacteriia 976|Bacteroidetes I TIGRFAM isopentenyl-diphosphate delta-isomerase, type 1 idi - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - NUDIX CMS2_k127_1023465_0 378806.STAUR_5205 5.108e-305 944.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria,2YXXC@29|Myxococcales 28221|Deltaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS2_k127_1023465_3 1499967.BAYZ01000095_gene4075 5.616e-85 288.0 COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria 2|Bacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 CMS2_k127_1023465_2 1047013.AQSP01000097_gene1943 1.591e-106 353.0 COG2362@1|root,COG2362@2|Bacteria,2NPDW@2323|unclassified Bacteria 2|Bacteria E D-aminopeptidase - - - ko:K16203 - - - - ko00000,ko01000,ko01002 3.A.1.5.2 - - Peptidase_M55 CMS2_k127_1023465_5 1279009.ADICEAN_03241 5.999e-61 228.0 COG0729@1|root,COG0729@2|Bacteria,4NMUN@976|Bacteroidetes,47Y2C@768503|Cytophagia 976|Bacteroidetes M Surface antigen - - - - - - - - - - - - Bac_surface_Ag CMS2_k127_1023465_4 1238425.J07HQW2_02656 4.007e-68 241.0 COG1575@1|root,arCOG00480@2157|Archaea 2157|Archaea H Belongs to the MenA family. Type 1 subfamily menA2 - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA CMS2_k127_1023465_1 335543.Sfum_1623 3.162e-141 464.0 COG3118@1|root,COG3118@2|Bacteria,1PQ8G@1224|Proteobacteria 1224|Proteobacteria O ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS CMS2_k127_1035337_15 861299.J421_5840 3.623e-48 178.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_1035337_13 861299.J421_5841 6.851e-97 339.0 COG4198@1|root,COG4198@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF1015,SusD-like_2 CMS2_k127_1035337_21 575540.Isop_3402 9.341e-18 96.0 COG2006@1|root,COG2006@2|Bacteria,2IYV1@203682|Planctomycetes 203682|Planctomycetes C Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 CMS2_k127_1035337_11 234267.Acid_4272 4.097e-110 387.0 COG0577@1|root,COG0577@2|Bacteria,3Y3K0@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1035337_19 313606.M23134_02452 4.001e-23 115.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia 976|Bacteroidetes G PFAM Glycosyl Hydrolase - - - - - - - - - - - - CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_92 CMS2_k127_1035337_5 929562.Emtol_0864 4.26e-168 550.0 COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,47JKY@768503|Cytophagia 976|Bacteroidetes P C-terminal region of aryl-sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C CMS2_k127_1035337_2 1121904.ARBP01000003_gene6415 1.425e-190 616.0 COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47JYR@768503|Cytophagia 976|Bacteroidetes P PFAM sulfatase - - - - - - - - - - - - DUF4976,Sulfatase CMS2_k127_1035337_10 1173022.Cri9333_4323 4.355e-130 435.0 COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7TU@1150|Oscillatoriales 1117|Cyanobacteria T COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,Response_reg CMS2_k127_1035337_0 1168034.FH5T_04755 2.878e-279 880.0 COG1509@1|root,COG1509@2|Bacteria,4NK6C@976|Bacteroidetes,2FMW5@200643|Bacteroidia 976|Bacteroidetes E KamA family eam - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - - CMS2_k127_1035337_17 1247963.JPHU01000012_gene902 3.137e-31 130.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 CMS2_k127_1035337_4 1121430.JMLG01000007_gene2533 9.893e-178 578.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,260H6@186807|Peptococcaceae 186801|Clostridia IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C CMS2_k127_1035337_1 396588.Tgr7_1082 4.797e-237 743.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS2_k127_1035337_7 344747.PM8797T_13048 1.155e-165 536.0 COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase CMS2_k127_1035337_8 314230.DSM3645_11237 2.532e-144 473.0 COG3119@1|root,COG3119@2|Bacteria,2IX9T@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - DUF4976,Sulfatase CMS2_k127_1035337_3 485913.Krac_5920 2.64e-179 573.0 COG0641@1|root,COG0641@2|Bacteria,2G74V@200795|Chloroflexi 200795|Chloroflexi C Iron-sulfur cluster-binding domain - - - ko:K06871 - - - - ko00000 - - - Radical_SAM,SPASM CMS2_k127_1035337_22 1047013.AQSP01000128_gene444 8.508e-14 82.0 2CK1R@1|root,32V4M@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_1035337_12 880073.Calab_0992 1.662e-99 333.0 COG2006@1|root,COG2006@2|Bacteria,2NQF7@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 CMS2_k127_1035337_6 448385.sce1086 5.528e-168 544.0 COG0348@1|root,COG1143@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2YW51@29|Myxococcales 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5,Fer4_7 CMS2_k127_1035337_14 156889.Mmc1_2108 4.537e-89 304.0 COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 CMS2_k127_1035337_16 156889.Mmc1_2110 2.433e-43 177.0 COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria 1224|Proteobacteria S PFAM aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red CMS2_k127_1035337_20 1408473.JHXO01000001_gene2145 2.354e-18 96.0 2CK1R@1|root,32V4M@2|Bacteria,4NTYZ@976|Bacteroidetes,2FU5M@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_1035337_9 234267.Acid_3470 1.729e-133 455.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1035337_18 391625.PPSIR1_29518 4.331e-28 119.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42S9C@68525|delta/epsilon subdivisions,2WM4G@28221|Deltaproteobacteria,2YU8Y@29|Myxococcales 28221|Deltaproteobacteria Q Dienelactone hydrolase family dlhH2 - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH CMS2_k127_1082266_0 1121022.ABENE_23565 2.285e-127 417.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,2KHTR@204458|Caulobacterales 204458|Caulobacterales L Winged helix-turn helix - - - - - - - - - - - - DDE_3 CMS2_k127_1082266_6 1122603.ATVI01000005_gene3501 2.19e-12 77.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales 1236|Gammaproteobacteria T Tetratricopeptide repeat - - - - - - - - - - - - Guanylate_cyc,TPR_19,TPR_2,TPR_8 CMS2_k127_1082266_10 1540221.JQNI01000002_gene817 0.0005741 53.0 COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria,1WIDK@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - NHL,Pkinase CMS2_k127_1082266_3 216432.CA2559_13238 1.377e-31 143.0 COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,1HXU8@117743|Flavobacteriia 976|Bacteroidetes V COG1680 Beta-lactamase class C and other penicillin binding - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase CMS2_k127_1082266_7 1117647.M5M_06385 9.916e-10 68.0 2CWKB@1|root,32SZW@2|Bacteria,1RD54@1224|Proteobacteria,1S4QG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1082266_5 861299.J421_0867 1.38e-18 91.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_0867|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_1082266_9 1057002.KB905370_gene1489 9.197e-05 52.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase cyaF - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8 CMS2_k127_1082266_8 96561.Dole_1738 3.212e-07 63.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,42NWR@68525|delta/epsilon subdivisions,2WK2E@28221|Deltaproteobacteria,2MI90@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - DUF3450,MotA_ExbB CMS2_k127_1082266_4 883.DvMF_3051 5.894e-26 120.0 COG1432@1|root,COG1432@2|Bacteria,1Q0F0@1224|Proteobacteria,42ZU4@68525|delta/epsilon subdivisions,2WV9A@28221|Deltaproteobacteria,2M84X@213115|Desulfovibrionales 28221|Deltaproteobacteria S NYN domain - - - - - - - - - - - - NYN CMS2_k127_1082266_2 314278.NB231_15718 1.247e-34 135.0 COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria 1224|Proteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 CMS2_k127_1082266_1 1101192.KB910516_gene659 1.452e-119 391.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,1JQUR@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 CMS2_k127_1109027_33 717231.Flexsi_0543 4.801e-21 102.0 COG0457@1|root,COG0457@2|Bacteria,2GG9Z@200930|Deferribacteres 200930|Deferribacteres S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2,TPR_8 CMS2_k127_1109027_23 379066.GAU_1963 1.114e-44 174.0 COG4105@1|root,COG4105@2|Bacteria,1ZTMC@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Outer membrane lipoprotein - - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO CMS2_k127_1109027_25 420246.GTNG_2458 4.768e-44 168.0 COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,4HGXK@91061|Bacilli,1WE1E@129337|Geobacillus 91061|Bacilli F Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like CMS2_k127_1109027_0 861299.J421_3566 0.0 1242.0 COG0653@1|root,COG0653@2|Bacteria,1ZSMK@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW CMS2_k127_1109027_17 861299.J421_3564 1.772e-73 255.0 COG2003@1|root,COG2003@2|Bacteria,1ZTFU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E RadC-like JAB domain - - - ko:K03630 - - - - ko00000 - - - RadC CMS2_k127_1109027_2 861299.J421_3563 3.249e-280 878.0 COG0317@1|root,COG0317@2|Bacteria,1ZT5M@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS CMS2_k127_1109027_1 379066.GAU_1953 3.467e-311 965.0 COG0556@1|root,COG0556@2|Bacteria,1ZSQS@142182|Gemmatimonadetes 142182|Gemmatimonadetes L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB CMS2_k127_1109027_31 1489678.RDMS_00175 1.173e-21 101.0 COG0802@1|root,COG0802@2|Bacteria,1WKEV@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM Uncharacterised P-loop hydrolase UPF0079 - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE CMS2_k127_1109027_34 767817.Desgi_2353 5.406e-20 100.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,261MZ@186807|Peptococcaceae 186801|Clostridia O PFAM Peptidase M22, glycoprotease yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Acetyltransf_1,Peptidase_M22 CMS2_k127_1109027_21 861299.J421_3557 4.72e-50 183.0 COG0629@1|root,COG0629@2|Bacteria,1ZTPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB CMS2_k127_1109027_37 404380.Gbem_2713 1.261e-15 89.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,42TT7@68525|delta/epsilon subdivisions,2WQR1@28221|Deltaproteobacteria,43TI3@69541|Desulfuromonadales 28221|Deltaproteobacteria S LysM domain - - - - - - - - - - - - LysM CMS2_k127_1109027_13 861299.J421_3555 3.775e-103 346.0 COG1087@1|root,COG1087@2|Bacteria,1ZSX3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd CMS2_k127_1109027_19 861299.J421_3554 1.089e-57 209.0 COG0811@1|root,COG0811@2|Bacteria,1ZTBF@142182|Gemmatimonadetes 142182|Gemmatimonadetes U MotA/TolQ/ExbB proton channel family - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB CMS2_k127_1109027_28 379066.GAU_1944 7.067e-31 132.0 COG0848@1|root,COG0848@2|Bacteria,1ZTRS@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD CMS2_k127_1109027_29 861299.J421_3552 2.116e-30 131.0 COG0810@1|root,COG0810@2|Bacteria,1ZTWX@142182|Gemmatimonadetes 142182|Gemmatimonadetes M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2 CMS2_k127_1109027_16 1379270.AUXF01000006_gene17 8.318e-79 282.0 COG0823@1|root,COG0823@2|Bacteria,1ZTBK@142182|Gemmatimonadetes 142182|Gemmatimonadetes U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS2_k127_1109027_27 1379281.AVAG01000021_gene1087 4.568e-32 134.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,2MC3Y@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA CMS2_k127_1109027_39 402881.Plav_2124 5.615e-11 72.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2U6ZQ@28211|Alphaproteobacteria,1JP5U@119043|Rhodobiaceae 28211|Alphaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri CMS2_k127_1109027_20 861299.J421_3548 5.471e-56 205.0 COG0805@1|root,COG0805@2|Bacteria,1ZTHN@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC CMS2_k127_1109027_9 1379270.AUXF01000006_gene21 5.911e-142 489.0 COG1452@1|root,COG1452@2|Bacteria,1ZT14@142182|Gemmatimonadetes 142182|Gemmatimonadetes M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - CMS2_k127_1109027_40 1379698.RBG1_1C00001G1236 1.245e-09 69.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - ko:K06882 - - - - ko00000 - - - fn3 CMS2_k127_1109027_36 204669.Acid345_4365 4.306e-19 91.0 2DNS7@1|root,32YWC@2|Bacteria,3Y609@57723|Acidobacteria,2JK5C@204432|Acidobacteriia 204432|Acidobacteriia J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP CMS2_k127_1109027_7 861299.J421_3546 1.878e-155 507.0 COG2986@1|root,COG2986@2|Bacteria,1ZTEG@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic CMS2_k127_1109027_3 379066.GAU_1936 1.577e-265 827.0 COG2987@1|root,COG2987@2|Bacteria,1ZSQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N CMS2_k127_1109027_12 861299.J421_3543 3.827e-105 356.0 COG1228@1|root,COG1228@2|Bacteria,1ZSNQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Amidohydrolase family hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_3 CMS2_k127_1109027_15 1379270.AUXF01000006_gene26 2.544e-84 309.0 COG0457@1|root,COG0457@2|Bacteria,1ZU0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 CMS2_k127_1109027_10 1379270.AUXF01000006_gene27 1.1e-108 361.0 COG0142@1|root,COG0142@2|Bacteria,1ZT7D@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Polyprenyl synthetase - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt CMS2_k127_1109027_35 379066.GAU_1931 2.326e-19 90.0 2FH8C@1|root,3492Q@2|Bacteria,1ZTXE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4321) - - - - - - - - - - - - DUF4321 CMS2_k127_1109027_38 926549.KI421517_gene1856 3.777e-11 68.0 COG1826@1|root,COG1826@2|Bacteria,4NUNH@976|Bacteroidetes,47S09@768503|Cytophagia 976|Bacteroidetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 CMS2_k127_1109027_11 1379270.AUXF01000006_gene30 2.908e-105 365.0 COG0760@1|root,COG0760@2|Bacteria,1ZTD1@142182|Gemmatimonadetes 142182|Gemmatimonadetes O SurA N-terminal domain - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N_2 CMS2_k127_1109027_32 1379270.AUXF01000006_gene31 1.571e-21 110.0 COG0457@1|root,COG0457@2|Bacteria,1ZTTU@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 CMS2_k127_1109027_24 1125863.JAFN01000001_gene2274 2.713e-44 165.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,42QU1@68525|delta/epsilon subdivisions,2WP6E@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II CMS2_k127_1109027_14 379066.GAU_1926 1.116e-93 320.0 COG0006@1|root,COG0006@2|Bacteria,1ZSTY@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Creatinase/Prolidase N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 CMS2_k127_1109027_18 518766.Rmar_0673 5.329e-59 209.0 COG0231@1|root,COG0231@2|Bacteria,4NDXA@976|Bacteroidetes,1FJ6E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C CMS2_k127_1109027_30 321332.CYB_0436 2.186e-29 123.0 COG0511@1|root,COG0511@2|Bacteria,1G6MY@1117|Cyanobacteria,1GZ7K@1129|Synechococcus 1117|Cyanobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl CMS2_k127_1109027_8 1379270.AUXF01000006_gene35 3.097e-154 497.0 COG2805@1|root,COG2805@2|Bacteria,1ZU8X@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS2_k127_1109027_5 768710.DesyoDRAFT_0926 3.284e-179 571.0 COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,26111@186807|Peptococcaceae 186801|Clostridia I TIGRFAM acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS2_k127_1109027_22 861299.J421_3532 5.94e-48 183.0 COG2045@1|root,COG2045@2|Bacteria,1ZTM8@142182|Gemmatimonadetes 142182|Gemmatimonadetes H 2-phosphosulpholactate phosphatase comB - 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp CMS2_k127_1109027_4 1379270.AUXF01000006_gene38 2.81e-190 623.0 COG1674@1|root,COG1674@2|Bacteria,1ZSPI@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Ftsk_gamma - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma CMS2_k127_1109027_26 861299.J421_3528 1.045e-34 139.0 COG0792@1|root,COG0792@2|Bacteria,1ZTWM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Uncharacterised protein family UPF0102 - - - ko:K07460 - - - - ko00000 - - - UPF0102 CMS2_k127_1109027_6 379066.GAU_1917 2.344e-164 524.0 COG0468@1|root,COG0468@2|Bacteria,1ZT78@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA CMS2_k127_1136883_6 1408473.JHXO01000001_gene2145 6.534e-14 82.0 2CK1R@1|root,32V4M@2|Bacteria,4NTYZ@976|Bacteroidetes,2FU5M@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_1136883_4 156889.Mmc1_2110 2.011e-39 165.0 COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria 1224|Proteobacteria S PFAM aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red CMS2_k127_1136883_2 96561.Dole_0398 7.119e-57 207.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase - - - - - - - - - - - - Aldo_ket_red,HEAT_2,TetR_C_7,TetR_N CMS2_k127_1136883_3 1232437.KL662026_gene969 3.323e-45 169.0 COG2020@1|root,COG2020@2|Bacteria,1RBJE@1224|Proteobacteria,42XPQ@68525|delta/epsilon subdivisions,2WT34@28221|Deltaproteobacteria,2MMDN@213118|Desulfobacterales 28221|Deltaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT CMS2_k127_1136883_1 697281.Mahau_2064 3.607e-182 593.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,42FYE@68295|Thermoanaerobacterales 186801|Clostridia G PFAM Glycoside hydrolase family 42 domain protein - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M CMS2_k127_1136883_0 1121904.ARBP01000027_gene733 1.445e-238 752.0 COG5492@1|root,COG5492@2|Bacteria,4NEAB@976|Bacteroidetes 976|Bacteroidetes N Domain of unknown function (DUF5060) - - - - - - - - - - - - Collagen_bind_2,DUF5060 CMS2_k127_1136883_5 1163407.UU7_09865 3.389e-33 141.0 2BHJY@1|root,32BNE@2|Bacteria,1PEBX@1224|Proteobacteria,1RUPY@1236|Gammaproteobacteria,1XBGQ@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - CMS2_k127_1152346_9 76114.ebA5622 4.301e-46 170.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales 206389|Rhodocyclales C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS2_k127_1152346_6 76114.ebA5630 4.541e-73 253.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,2KUFD@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11 CMS2_k127_1152346_10 1123376.AUIU01000012_gene1472 2.564e-23 111.0 COG3301@1|root,COG3301@2|Bacteria 2|Bacteria P Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD,NrfD_2 CMS2_k127_1152346_7 1449050.JNLE01000003_gene567 1.782e-50 189.0 COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,36DZN@31979|Clostridiaceae 186801|Clostridia L Formamidopyrimidine-DNA glycosylase H2TH domain - - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS CMS2_k127_1152346_13 7739.XP_002597967.1 1.136e-05 56.0 KOG0613@1|root,KOG4221@1|root,KOG0613@2759|Eukaryota,KOG4221@2759|Eukaryota,38BAS@33154|Opisthokonta,3B9IR@33208|Metazoa,3CRJW@33213|Bilateria,484DC@7711|Chordata 33208|Metazoa T Titin-like unc-22 GO:0000070,GO:0000228,GO:0000278,GO:0000280,GO:0000768,GO:0000793,GO:0000794,GO:0000819,GO:0002682,GO:0003008,GO:0003012,GO:0003674,GO:0003779,GO:0003824,GO:0004672,GO:0004674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005856,GO:0005859,GO:0005863,GO:0006323,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006936,GO:0006937,GO:0006941,GO:0006942,GO:0006949,GO:0006996,GO:0007010,GO:0007015,GO:0007049,GO:0007059,GO:0007062,GO:0007076,GO:0007275,GO:0007498,GO:0007517,GO:0007519,GO:0007520,GO:0007522,GO:0007525,GO:0007610,GO:0007626,GO:0008092,GO:0008150,GO:0008152,GO:0008307,GO:0008344,GO:0009636,GO:0009653,GO:0009888,GO:0009987,GO:0010638,GO:0010720,GO:0010927,GO:0014706,GO:0014902,GO:0015629,GO:0016043,GO:0016203,GO:0016301,GO:0016310,GO:0016459,GO:0016460,GO:0016740,GO:0016772,GO:0016773,GO:0018105,GO:0018107,GO:0018193,GO:0018209,GO:0018210,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0022402,GO:0022603,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030261,GO:0030534,GO:0031032,GO:0031033,GO:0031034,GO:0031430,GO:0031672,GO:0031674,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032956,GO:0032970,GO:0032982,GO:0032989,GO:0032991,GO:0033043,GO:0034622,GO:0035094,GO:0035095,GO:0035206,GO:0036211,GO:0036379,GO:0040011,GO:0040012,GO:0040017,GO:0042127,GO:0042221,GO:0042493,GO:0042692,GO:0042805,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043292,GO:0043412,GO:0043933,GO:0044057,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0044877,GO:0045214,GO:0045595,GO:0045597,GO:0045933,GO:0045989,GO:0048285,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048646,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051015,GO:0051094,GO:0051128,GO:0051130,GO:0051146,GO:0051147,GO:0051149,GO:0051153,GO:0051155,GO:0051239,GO:0051240,GO:0051276,GO:0051302,GO:0051371,GO:0051393,GO:0051493,GO:0051495,GO:0051782,GO:0055001,GO:0055002,GO:0060284,GO:0060297,GO:0060298,GO:0060537,GO:0060538,GO:0061061,GO:0065003,GO:0065007,GO:0070013,GO:0070925,GO:0071103,GO:0071688,GO:0071689,GO:0071704,GO:0071840,GO:0090257,GO:0097435,GO:0097493,GO:0098813,GO:0099080,GO:0099081,GO:0099512,GO:0110020,GO:0140014,GO:0140096,GO:1901564,GO:1902115,GO:1902117,GO:1902903,GO:1902905,GO:1903047 2.7.11.1 ko:K12567 ko05410,ko05414,map05410,map05414 - - - ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812 - - - DUF1136,I-set,Ig_3,Pkinase,fn3 CMS2_k127_1152346_0 1121440.AUMA01000005_gene2558 1.849e-240 756.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2M845@213115|Desulfovibrionales 28221|Deltaproteobacteria BQ PFAM Histone deacetylase - - - - - - - - - - - - Acetyltransf_1,Hist_deacetyl CMS2_k127_1152346_8 485916.Dtox_0046 3.801e-47 175.0 COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,261U9@186807|Peptococcaceae 186801|Clostridia C PFAM pyruvate ferredoxin flavodoxin oxidoreductase iorB - 1.2.7.8 ko:K00180 - - - - br01601,ko00000,ko01000 - - - POR CMS2_k127_1152346_1 555079.Toce_1564 2.006e-178 578.0 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,42EZ8@68295|Thermoanaerobacterales 186801|Clostridia C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,Fer4_10,POR_N,TPP_enzyme_C CMS2_k127_1152346_5 393595.ABO_0204 2.958e-75 259.0 COG1305@1|root,COG1305@2|Bacteria,1MW3P@1224|Proteobacteria,1RSQ5@1236|Gammaproteobacteria,1XMKP@135619|Oceanospirillales 135619|Oceanospirillales E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core CMS2_k127_1152346_3 1379698.RBG1_1C00001G0513 5.339e-140 456.0 COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria 2|Bacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA3 - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like CMS2_k127_1152346_12 225117.XP_009379721.1 1.453e-13 80.0 COG3914@1|root,KOG4626@2759|Eukaryota,37RD4@33090|Viridiplantae,3G7FD@35493|Streptophyta,4JNCY@91835|fabids 35493|Streptophyta GOT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC - GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.255 ko:K09667 ko00514,ko04931,map00514,map04931 - R09304,R09676 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003,ko03036 - GT41 - Glyco_transf_41,TPR_1,TPR_11,TPR_2,TPR_8 CMS2_k127_1152346_4 1379698.RBG1_1C00001G0516 1.089e-139 452.0 COG0473@1|root,COG0473@2|Bacteria,2NP1R@2323|unclassified Bacteria 2|Bacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS2_k127_1152346_2 224325.AF_0931 2.938e-152 499.0 COG0303@1|root,arCOG00217@2157|Archaea,2XT2V@28890|Euryarchaeota,245ZM@183980|Archaeoglobi 183980|Archaeoglobi H Molybdenum cofactor synthesis domain protein - - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like CMS2_k127_115923_4 1379270.AUXF01000002_gene1589 4.155e-42 156.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_115923_2 880073.Calab_1134 2.721e-214 699.0 COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_115923_1 886293.Sinac_6948 2.075e-247 775.0 COG0665@1|root,COG0665@2|Bacteria,2J4YV@203682|Planctomycetes 203682|Planctomycetes E FAD dependent oxidoreductase - - - - - - - - - - - - FAD_oxidored CMS2_k127_115923_6 234267.Acid_3946 4.039e-06 55.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4440,SnoaL_3 CMS2_k127_115923_5 886293.Sinac_7277 5.663e-32 132.0 COG0694@1|root,COG0694@2|Bacteria 2|Bacteria O iron-sulfur cluster assembly nfuA - - ko:K07400 - - - - ko00000 - - - Nfu_N,NifU CMS2_k127_115923_3 1191523.MROS_1660 2.152e-175 560.0 COG4992@1|root,COG4992@2|Bacteria 2|Bacteria E N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity rocD GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iYO844.BSU40340 Aminotran_3 CMS2_k127_115923_0 1519464.HY22_00255 0.0 1171.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 CMS2_k127_1251834_10 861299.J421_0308 7.992e-66 229.0 COG1595@1|root,COG1595@2|Bacteria,1ZTP3@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_1251834_6 861299.J421_0306 1.166e-83 295.0 COG1413@1|root,COG1413@2|Bacteria,1ZTQY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS2_k127_1251834_7 861299.J421_0306 6.346e-73 258.0 COG1413@1|root,COG1413@2|Bacteria,1ZTQY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS2_k127_1251834_9 861299.J421_0305 9.215e-67 237.0 COG1413@1|root,COG1413@2|Bacteria,1ZTU2@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS2_k127_1251834_3 246197.MXAN_6435 5.758e-138 453.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,43C89@68525|delta/epsilon subdivisions,2X7IN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 CMS2_k127_1251834_0 1192034.CAP_6894 6.032e-200 632.0 COG1196@1|root,COG1196@2|Bacteria,1R3XQ@1224|Proteobacteria,42YF5@68525|delta/epsilon subdivisions,2WUDV@28221|Deltaproteobacteria,2YUHS@29|Myxococcales 28221|Deltaproteobacteria D 5' nucleotidase family surE2 - - - - - - - - - - - 5_nucleotid CMS2_k127_1251834_8 1449080.JQMV01000003_gene1071 1.143e-71 251.0 COG0351@1|root,COG0351@2|Bacteria,1WIN0@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin CMS2_k127_1251834_15 861299.J421_3833 1.183e-52 195.0 COG0566@1|root,COG0566@2|Bacteria,1ZTVA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J RNA 2'-O ribose methyltransferase substrate binding - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind CMS2_k127_1251834_13 379066.GAU_2351 1.162e-62 224.0 COG1989@1|root,COG1989@2|Bacteria,1ZT9K@142182|Gemmatimonadetes 142182|Gemmatimonadetes NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 CMS2_k127_1251834_16 861299.J421_4375 2.212e-50 184.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_1251834_26 379066.GAU_2724 1.056e-10 71.0 2F756@1|root,33ZKP@2|Bacteria,1ZU38@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1251834_21 861299.J421_4377 1.455e-29 128.0 COG3595@1|root,COG3595@2|Bacteria,1ZU53@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative adhesin - - - - - - - - - - - - DUF4097 CMS2_k127_1251834_18 1379270.AUXF01000001_gene2631 2.756e-46 177.0 COG3595@1|root,COG3595@2|Bacteria,1ZTQ0@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - DUF4097 CMS2_k127_1251834_11 379066.GAU_2350 1.175e-63 235.0 COG2856@1|root,COG2856@2|Bacteria,1ZSXU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zn peptidase - - - - - - - - - - - - - CMS2_k127_1251834_25 1430331.EP10_04190 4.533e-12 79.0 COG4399@1|root,COG4399@2|Bacteria,1TQDH@1239|Firmicutes,4HA30@91061|Bacilli,1WEDY@129337|Geobacillus 91061|Bacilli S Protein of unknown function (DUF445) yheB - - - - - - - - - - - DUF445 CMS2_k127_1251834_4 586413.CCDL010000002_gene2673 1.097e-117 395.0 COG0786@1|root,COG0786@2|Bacteria,1U36J@1239|Firmicutes,4HAXA@91061|Bacilli,23JSR@182709|Oceanobacillus 91061|Bacilli E Sodium/glutamate symporter - - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter CMS2_k127_1251834_2 1379270.AUXF01000003_gene3580 2.488e-162 522.0 COG0541@1|root,COG0541@2|Bacteria,1ZSPG@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB CMS2_k127_1251834_22 1329516.JPST01000007_gene1514 2.56e-25 107.0 COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli,27C4Q@186824|Thermoactinomycetaceae 91061|Bacilli J Ribosomal protein S16 rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 CMS2_k127_1251834_23 1078020.KEK_18708 1.218e-23 109.0 COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,238SB@1762|Mycobacteriaceae 201174|Actinobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM GO:0008150,GO:0040007 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM CMS2_k127_1251834_5 861299.J421_3824 4.546e-85 291.0 COG0336@1|root,COG0336@2|Bacteria,1ZT8K@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT CMS2_k127_1251834_19 861299.J421_3822 3.759e-44 164.0 COG0335@1|root,COG0335@2|Bacteria,1ZTUC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 CMS2_k127_1251834_14 479434.Sthe_0472 4.121e-57 209.0 COG0164@1|root,COG0164@2|Bacteria,2G6KR@200795|Chloroflexi,27YAF@189775|Thermomicrobia 189775|Thermomicrobia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII CMS2_k127_1251834_20 1379270.AUXF01000001_gene2333 5.129e-32 132.0 COG5531@1|root,COG5531@2|Bacteria,1ZTZP@142182|Gemmatimonadetes 142182|Gemmatimonadetes B SWI complex, BAF60b domains - - - - - - - - - - - - SWIB CMS2_k127_1251834_1 861299.J421_0271 1.343e-190 613.0 COG4585@1|root,COG4585@2|Bacteria,1ZSM2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Histidine kinase - - - - - - - - - - - - HisKA_3 CMS2_k127_1251834_12 379066.GAU_2230 1.459e-63 227.0 COG2197@1|root,COG2197@2|Bacteria,1ZTJ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg CMS2_k127_1251834_17 880072.Desac_1962 3.633e-50 203.0 COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,43CF9@68525|delta/epsilon subdivisions,2X7QB@28221|Deltaproteobacteria,2MS55@213462|Syntrophobacterales 28221|Deltaproteobacteria P Outer membrane protein beta-barrel family - - - ko:K16087,ko:K16092 - - - - ko00000,ko02000 1.B.14.2,1.B.14.3 - - Plug,TonB_dep_Rec CMS2_k127_1271201_2 1112216.JH594425_gene3063 1.281e-16 85.0 COG0457@1|root,COG0457@2|Bacteria,1NKPJ@1224|Proteobacteria,2UM7X@28211|Alphaproteobacteria,2K5JZ@204457|Sphingomonadales 204457|Sphingomonadales S Tetratricopeptide repeat - - - - - - - - - - - - - CMS2_k127_1271201_4 1268622.AVS7_01085 6.415e-05 55.0 COG3055@1|root,COG4447@1|root,COG5279@1|root,COG3055@2|Bacteria,COG4447@2|Bacteria,COG5279@2|Bacteria,1R0N3@1224|Proteobacteria 1224|Proteobacteria D cellulose binding - - - - - - - - - - - - - CMS2_k127_1271201_0 926560.KE387025_gene4131 1.105e-35 147.0 COG1028@1|root,COG1028@2|Bacteria,1WM2Z@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short CMS2_k127_1271201_1 1304885.AUEY01000038_gene2579 1.609e-22 104.0 2C82W@1|root,33GR4@2|Bacteria,1R3CI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_1271201_3 765912.Thimo_0400 1.077e-14 80.0 COG1670@1|root,COG1670@2|Bacteria,1NEA7@1224|Proteobacteria,1SEG2@1236|Gammaproteobacteria 1236|Gammaproteobacteria J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - - - - - - - - - - - CMS2_k127_1276770_14 1254432.SCE1572_12540 9.461e-111 386.0 COG0664@1|root,COG1413@1|root,COG3202@1|root,COG0664@2|Bacteria,COG1413@2|Bacteria,COG3202@2|Bacteria,1N61M@1224|Proteobacteria,42Y1U@68525|delta/epsilon subdivisions,2WNPK@28221|Deltaproteobacteria,2Z01S@29|Myxococcales 28221|Deltaproteobacteria CT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HEAT_2,TLC,cNMP_binding CMS2_k127_1276770_34 1297742.A176_01528 2.382e-05 57.0 COG0457@1|root,COG0457@2|Bacteria 1297742.A176_01528|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_1276770_3 1121904.ARBP01000003_gene6372 5.853e-185 596.0 COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,47K7D@768503|Cytophagia 976|Bacteroidetes P esterase - - - - - - - - - - - - Esterase CMS2_k127_1276770_11 1267535.KB906767_gene5108 1.382e-155 521.0 COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria,2JITF@204432|Acidobacteriia 204432|Acidobacteriia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1276770_25 861299.J421_1084 1.256e-35 138.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_1276770_8 452637.Oter_1883 2.796e-168 561.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1276770_5 742817.HMPREF9449_00219 1.429e-176 561.0 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,4NFUN@976|Bacteroidetes,2FNNY@200643|Bacteroidia,22VV0@171551|Porphyromonadaceae 976|Bacteroidetes S membrane spmA - - ko:K06373 - - - - ko00000 - - - Gate CMS2_k127_1276770_24 998674.ATTE01000001_gene3159 1.198e-65 231.0 COG2866@1|root,COG2866@2|Bacteria,1N9AY@1224|Proteobacteria,1RRGU@1236|Gammaproteobacteria,4625I@72273|Thiotrichales 72273|Thiotrichales E Zn_pept - - - - - - - - - - - - Peptidase_M14 CMS2_k127_1276770_23 1123279.ATUS01000006_gene3508 8.355e-69 243.0 COG1876@1|root,COG1876@2|Bacteria,1N2IC@1224|Proteobacteria,1S0DU@1236|Gammaproteobacteria,1J68J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG1876 D-alanyl-D-alanine carboxypeptidase vanY - - - - - - - - - - - VanY CMS2_k127_1276770_21 84531.JMTZ01000010_gene3141 4.95e-70 250.0 2DCFR@1|root,2ZDYQ@2|Bacteria,1RB5X@1224|Proteobacteria,1RN4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1276770_20 926550.CLDAP_32000 7.265e-75 263.0 COG0225@1|root,COG0225@2|Bacteria,2G6JK@200795|Chloroflexi 200795|Chloroflexi C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR CMS2_k127_1276770_31 1379270.AUXF01000001_gene2088 2.168e-11 71.0 2DDI2@1|root,2ZI6I@2|Bacteria,1ZVAF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1276770_2 234267.Acid_5961 8.973e-205 669.0 COG0577@1|root,COG0577@2|Bacteria,3Y7CU@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1276770_28 234267.Acid_4721 3.551e-28 117.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR CMS2_k127_1276770_33 1201288.M900_0608 5.87e-06 57.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS2_k127_1276770_9 1379270.AUXF01000002_gene1290 9.264e-164 553.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_1276770_29 485913.Krac_5098 3.84e-27 115.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_1276770_10 1144275.COCOR_05906 1.933e-161 542.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria 1224|Proteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1276770_16 555779.Dthio_PD3478 1.88e-87 301.0 COG2006@1|root,COG2006@2|Bacteria,1NV7D@1224|Proteobacteria,42ZEV@68525|delta/epsilon subdivisions,2WV1N@28221|Deltaproteobacteria,2M8BU@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 CMS2_k127_1276770_7 700598.Niako_7010 1.617e-168 548.0 COG2234@1|root,COG2234@2|Bacteria,4NIAY@976|Bacteroidetes,1IVXK@117747|Sphingobacteriia 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS2_k127_1276770_0 1047013.AQSP01000134_gene1354 2.689e-234 739.0 COG2382@1|root,COG2382@2|Bacteria 2|Bacteria P enterobactin catabolic process - - - - - - - - - - - - Esterase CMS2_k127_1276770_17 861299.J421_6084 1.347e-82 290.0 28P8D@1|root,33QB6@2|Bacteria,1ZSQK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD_RagB CMS2_k127_1276770_1 1379270.AUXF01000003_gene3454 1.746e-206 678.0 COG1629@1|root,COG4771@2|Bacteria,1ZT9M@142182|Gemmatimonadetes 142182|Gemmatimonadetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_1276770_4 1183438.GKIL_4354 9.757e-182 596.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1276770_30 861299.J421_2836 7.886e-24 109.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_2836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_1276770_32 1144275.COCOR_01658 9.424e-08 62.0 28QQ1@1|root,2ZD5J@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_1276770_15 379066.GAU_0174 8.715e-109 361.0 COG3340@1|root,COG3340@2|Bacteria,1ZUA9@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family S51 - - - - - - - - - - - - Peptidase_S51 CMS2_k127_1276770_6 331869.BAL199_11716 3.022e-175 564.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,4BPEV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS2_k127_1276770_18 1121271.AUCM01000005_gene876 1.89e-79 272.0 COG1028@1|root,COG1028@2|Bacteria,1R6S5@1224|Proteobacteria,2U353@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ short-chain dehydrogenase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS2_k127_1276770_12 331869.BAL199_11726 2.824e-144 464.0 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C CMS2_k127_1276770_19 864069.MicloDRAFT_00053740 1.3e-78 271.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,2TTHV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS2_k127_1276770_13 1449049.JONW01000006_gene3304 7.171e-137 447.0 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2TUM5@28211|Alphaproteobacteria,2KK7G@204458|Caulobacterales 204458|Caulobacterales EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 CMS2_k127_1276770_27 1121875.KB907550_gene730 1.528e-31 130.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated padR - - - - - - - - - - - DUF2703,PadR,Vir_act_alpha_C CMS2_k127_1276770_26 1288963.ADIS_3103 2.779e-35 149.0 2ET8I@1|root,33KSM@2|Bacteria,4NZEX@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_1276770_22 518766.Rmar_2799 5.522e-69 245.0 COG3016@1|root,COG3016@2|Bacteria,4NEQ4@976|Bacteroidetes 976|Bacteroidetes S Iron-regulated protein - - - - - - - - - - - - Cofac_haem_bdg CMS2_k127_1285617_3 251221.35211765 1.434e-108 380.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_1285617_8 251221.35211766 1.034e-16 84.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_1285617_4 861299.J421_6371 1.894e-83 297.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6371|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_1285617_5 861299.J421_6371 7.568e-83 296.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6371|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_1285617_9 1280941.HY2_02780 1.383e-06 55.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_32,rve CMS2_k127_1285617_7 251221.35211248 4.776e-22 100.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_1285617_1 251221.35211765 5.464e-151 515.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_1285617_0 391603.FBALC1_11417 3.452e-152 488.0 COG2267@1|root,COG2267@2|Bacteria,4NFIJ@976|Bacteroidetes,1IJDM@117743|Flavobacteriia 976|Bacteroidetes I Releases the N-terminal proline from various substrates fpaP - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 CMS2_k127_1285617_6 682795.AciX8_4833 4.053e-28 118.0 COG1695@1|root,COG1695@2|Bacteria,3Y8CC@57723|Acidobacteria,2JP3G@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_1285617_2 861299.J421_1266 2.315e-139 480.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_1266|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_1360918_1 1279009.ADICEAN_03090 5.545e-105 349.0 COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,47U45@768503|Cytophagia 976|Bacteroidetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_1360918_0 1499967.BAYZ01000115_gene2932 1.925e-269 837.0 COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2NP28@2323|unclassified Bacteria 2|Bacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.1,2.1.2.10,2.2.1.8 ko:K00600,ko:K00605,ko:K18847 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R01221,R02300,R04125,R09099 RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C,SHMT CMS2_k127_1364469_3 338966.Ppro_1571 1.809e-26 109.0 COG3961@1|root,COG3961@2|Bacteria,1MW2F@1224|Proteobacteria,42NMB@68525|delta/epsilon subdivisions,2WKP7@28221|Deltaproteobacteria,43TST@69541|Desulfuromonadales 28221|Deltaproteobacteria GH Belongs to the TPP enzyme family - - 4.1.1.74 ko:K04103 ko00380,ko01100,map00380,map01100 - R01974 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N CMS2_k127_1364469_0 378806.STAUR_7238 2.821e-92 323.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS2_k127_1364469_2 86416.Clopa_1062 2.309e-37 149.0 COG1309@1|root,COG1309@2|Bacteria,1V9XJ@1239|Firmicutes,24I61@186801|Clostridia,36IR0@31979|Clostridiaceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N,WHG CMS2_k127_1364469_1 876044.IMCC3088_1309 1.423e-39 164.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,1JA3N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B CMS2_k127_1408609_8 313596.RB2501_12627 5.918e-13 80.0 COG4974@1|root,COG4974@2|Bacteria,4NE0E@976|Bacteroidetes,1HYPM@117743|Flavobacteriia 976|Bacteroidetes L Tyrosine recombinase XerC xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase CMS2_k127_1408609_9 1246474.ANBE01000002_gene4094 4.096e-06 59.0 COG0151@1|root,COG0151@2|Bacteria,2GKTF@201174|Actinobacteria,4EJ91@85012|Streptosporangiales 201174|Actinobacteria F ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 CMS2_k127_1408609_1 1214101.BN159_p17 3.397e-30 130.0 COG3555@1|root,COG3555@2|Bacteria,2IBR0@201174|Actinobacteria 201174|Actinobacteria O Aspartyl/Asparaginyl beta-hydroxylase - - - - - - - - - - - - Asp_Arg_Hydrox CMS2_k127_1408609_6 649831.L083_5572 7.367e-20 91.0 COG3251@1|root,COG3251@2|Bacteria,2GQIK@201174|Actinobacteria,4DFYE@85008|Micromonosporales 201174|Actinobacteria S MbtH domain protein - - - ko:K05375 ko00261,ko01130,map00261,map01130 M00736 R10880 RC00064,RC00141,RC03296,RC03297,RC03298 ko00000,ko00001,ko00002 - - - MbtH CMS2_k127_1408609_5 509635.N824_24615 2.411e-24 111.0 COG4912@1|root,COG4912@2|Bacteria,4PIP1@976|Bacteroidetes,1IXK7@117747|Sphingobacteriia 976|Bacteroidetes L DNA alkylation repair enzyme - - - - - - - - - - - - DNA_alkylation CMS2_k127_1408609_2 1121936.AUHI01000016_gene108 1.678e-26 114.0 28XTZ@1|root,2ZJQD@2|Bacteria,1W5V2@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - CMS2_k127_1408609_0 479433.Caci_2589 5.246e-89 314.0 COG5285@1|root,COG5285@2|Bacteria,2GPSA@201174|Actinobacteria 201174|Actinobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - ko:K15650 - - - - ko00000,ko01008 - - - PhyH CMS2_k127_1408609_7 649764.HMPREF0762_01225 8.692e-18 95.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4CVZ3@84998|Coriobacteriia 84998|Coriobacteriia E PFAM Aminotransferase class I and II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_1408609_4 1206735.BAGG01000266_gene6965 6.895e-25 112.0 COG0119@1|root,COG0119@2|Bacteria,2GJBI@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds mhpE - 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like CMS2_k127_1414411_22 886293.Sinac_2233 1.181e-25 111.0 COG4911@1|root,COG4911@2|Bacteria,2J02T@203682|Planctomycetes 203682|Planctomycetes S conserved protein (DUF2203) - - - - - - - - - - - - DUF2203 CMS2_k127_1414411_21 379066.GAU_2619 1.497e-32 138.0 COG1141@1|root,COG1752@1|root,COG1141@2|Bacteria,COG1752@2|Bacteria,1ZT7Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S single cluster domain - - - ko:K07001 - - - - ko00000 - - - Fer4_15,Patatin CMS2_k127_1414411_2 861299.J421_4453 6.135e-195 629.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1ZTC2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H NAD synthase - - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase CMS2_k127_1414411_16 861299.J421_4352 7.894e-45 174.0 COG1801@1|root,COG1801@2|Bacteria 2|Bacteria L Protein of unknown function DUF72 yecE - - - - - - - - - - - DUF72 CMS2_k127_1414411_25 931627.MycrhDRAFT_6044 5.678e-07 57.0 COG4319@1|root,COG4319@2|Bacteria,2INEA@201174|Actinobacteria 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 CMS2_k127_1414411_13 1137271.AZUM01000007_gene3269 3.671e-46 179.0 COG1957@1|root,COG1957@2|Bacteria,2GP6N@201174|Actinobacteria,4E0B2@85010|Pseudonocardiales 201174|Actinobacteria F nucleoside hydrolase rihA - - ko:K01250 - - - - ko00000,ko01000 - - - IU_nuc_hydro CMS2_k127_1414411_17 224325.AF_1206 1.013e-44 176.0 COG1250@1|root,arCOG00251@2157|Archaea,2Y3BN@28890|Euryarchaeota,246SW@183980|Archaeoglobi 183980|Archaeoglobi I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - - - - - - - - - - 3HCDH,3HCDH_N CMS2_k127_1414411_7 1379270.AUXF01000001_gene2649 1.551e-69 243.0 COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1ZTHJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix diphteria tox regulatory element - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress,FeoA CMS2_k127_1414411_20 379066.GAU_2716 1.016e-36 145.0 COG1051@1|root,COG1051@2|Bacteria,1ZU0E@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NUDIX domain - - - - - - - - - - - - NUDIX CMS2_k127_1414411_19 880073.Calab_0866 1.69e-37 153.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity luxD - 3.2.1.4,4.2.99.18 ko:K01179,ko:K06889,ko:K10773,ko:K15853 ko00500,ko01100,ko02020,ko02024,ko03410,map00500,map01100,map02020,map02024,map03410 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko03400 - GH5,GH9 - Abhydrolase_1,Acyl_transf_2,DLH,Hydrolase_4,Peptidase_S9 CMS2_k127_1414411_6 1125863.JAFN01000001_gene207 4.594e-92 310.0 COG1028@1|root,COG1028@2|Bacteria,1QXA0@1224|Proteobacteria,42UQH@68525|delta/epsilon subdivisions,2WQ5R@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 CMS2_k127_1414411_3 289376.THEYE_A0567 3.822e-165 530.0 COG1960@1|root,COG1960@2|Bacteria,3J13U@40117|Nitrospirae 40117|Nitrospirae C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS2_k127_1414411_11 861299.J421_0392 1.32e-62 231.0 COG1301@1|root,COG1301@2|Bacteria,1ZTDM@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF CMS2_k127_1414411_8 861299.J421_0392 8.949e-69 249.0 COG1301@1|root,COG1301@2|Bacteria,1ZTDM@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF CMS2_k127_1414411_15 1294143.H681_07825 5.897e-45 167.0 2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria 1224|Proteobacteria S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 CMS2_k127_1414411_1 485913.Krac_3042 1.741e-273 856.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 CMS2_k127_1414411_12 861299.J421_2170 3.371e-57 228.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_1414411_26 342949.PNA2_0193 1.544e-06 57.0 COG2306@1|root,arCOG05760@2157|Archaea,2XX0W@28890|Euryarchaeota,243ZF@183968|Thermococci 183968|Thermococci S Protein of unknown function (DUF402) - - - ko:K09145 - - - - ko00000 - - - DUF402 CMS2_k127_1414411_5 861299.J421_4374 2.885e-127 444.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1ZT3Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes LV DNA restriction-modification system - - - - - - - - - - - - N6_Mtase CMS2_k127_1414411_14 1379270.AUXF01000001_gene2636 1.526e-45 188.0 COG0553@1|root,COG0553@2|Bacteria,1ZUB8@142182|Gemmatimonadetes 142182|Gemmatimonadetes L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N CMS2_k127_1414411_27 273068.TTE2024 0.0004874 46.0 2CDVC@1|root,33CB9@2|Bacteria,1VMWX@1239|Firmicutes,24WHP@186801|Clostridia,42HJ4@68295|Thermoanaerobacterales 186801|Clostridia - - - - - - - - - - - - - - - CMS2_k127_1414411_9 379066.GAU_2730 9.377e-64 234.0 COG1533@1|root,COG1533@2|Bacteria,1ZUFM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM CMS2_k127_1414411_10 479434.Sthe_2045 6.805e-63 235.0 COG0389@1|root,COG0389@2|Bacteria 2|Bacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII imuB - 2.7.7.7 ko:K02346,ko:K14161 - - - - ko00000,ko01000,ko03400 - - - IMS CMS2_k127_1414411_23 479434.Sthe_2046 9.461e-16 80.0 29U2R@1|root,30FC1@2|Bacteria,2G9M3@200795|Chloroflexi 200795|Chloroflexi - - - - - - - - - - - - - - - CMS2_k127_1414411_0 1380390.JIAT01000010_gene3508 9.661e-284 907.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CPV2@84995|Rubrobacteria 84995|Rubrobacteria L Helix-hairpin-helix motif - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP CMS2_k127_1414411_4 861299.J421_4428 6.379e-153 494.0 COG0761@1|root,COG0761@2|Bacteria,1ZTGU@142182|Gemmatimonadetes 142182|Gemmatimonadetes C LytB protein - - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB CMS2_k127_1414411_18 1379270.AUXF01000001_gene2323 8.764e-38 163.0 2EXVN@1|root,33R4S@2|Bacteria,1ZTD4@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1414411_24 1121441.AUCX01000021_gene717 3.463e-07 54.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJKZ@28221|Deltaproteobacteria,2MGPR@213115|Desulfovibrionales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_1477420_29 1125701.HMPREF1221_01616 1.79e-39 164.0 COG2407@1|root,COG2407@2|Bacteria 2|Bacteria G Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - - - - - - - - - - - CMS2_k127_1477420_26 1125701.HMPREF1221_01616 1.031e-48 194.0 COG2407@1|root,COG2407@2|Bacteria 2|Bacteria G Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - - - - - - - - - - - CMS2_k127_1477420_4 861299.J421_2518 6.149e-207 653.0 COG1239@1|root,COG1239@2|Bacteria,1ZT0R@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - - CMS2_k127_1477420_5 861299.J421_2513 2.864e-193 613.0 COG4867@1|root,COG4867@2|Bacteria,1ZT0B@142182|Gemmatimonadetes 142182|Gemmatimonadetes S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA_2 CMS2_k127_1477420_27 861299.J421_6034 1.411e-47 196.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS2_k127_1477420_31 861299.J421_1084 3.546e-37 143.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_1477420_8 251221.35211765 7.794e-151 511.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_1477420_21 485913.Krac_10280 3.163e-60 220.0 COG0596@1|root,COG0596@2|Bacteria,2G6VQ@200795|Chloroflexi 2|Bacteria S PFAM alpha beta hydrolase fold MA20_20400 - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1,Abhydrolase_6 CMS2_k127_1477420_40 588581.Cpap_0287 2.879e-12 74.0 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - - - - - - - - - - - PEMT CMS2_k127_1477420_42 768066.HELO_3797 1.323e-06 60.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1XH5P@135619|Oceanospirillales 135619|Oceanospirillales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 CMS2_k127_1477420_18 56780.SYN_02522 1.156e-98 328.0 COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,42NWG@68525|delta/epsilon subdivisions,2WKEU@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM ADP-ribosylation Crystallin J1 - - - - - - - - - - - - ADP_ribosyl_GH CMS2_k127_1477420_23 684949.ATTJ01000001_gene2027 6.228e-58 211.0 COG2333@1|root,COG2333@2|Bacteria,1WJ6M@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L DNA internalization-related competence protein ComEC Rec2 - - - - - - - - - - - - Lactamase_B CMS2_k127_1477420_15 1121405.dsmv_1907 2.212e-104 357.0 COG1397@1|root,COG2365@1|root,COG1397@2|Bacteria,COG2365@2|Bacteria,1NTUR@1224|Proteobacteria,42NWG@68525|delta/epsilon subdivisions,2WJYQ@28221|Deltaproteobacteria,2MJ49@213118|Desulfobacterales 28221|Deltaproteobacteria O ADP-ribosylglycohydrolase - - 3.2.2.24 ko:K05521 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH CMS2_k127_1477420_11 1379270.AUXF01000004_gene3298 4.208e-135 455.0 COG4206@1|root,COG4206@2|Bacteria,1ZUAE@142182|Gemmatimonadetes 142182|Gemmatimonadetes H TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug CMS2_k127_1477420_16 379066.GAU_2880 4.861e-100 343.0 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - - - - - - - - - - - HAMP,HATPase_c,HisKA CMS2_k127_1477420_20 379066.GAU_2879 1.246e-64 229.0 COG0745@1|root,COG0745@2|Bacteria 379066.GAU_2879|- T phosphorelay signal transduction system - - - ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - - CMS2_k127_1477420_0 251221.35211322 0.0 1118.0 COG2866@1|root,COG2866@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS2_k127_1477420_37 883.DvMF_1877 1.174e-24 110.0 arCOG08935@1|root,338YH@2|Bacteria,1N8JH@1224|Proteobacteria,43DKA@68525|delta/epsilon subdivisions,2WSNG@28221|Deltaproteobacteria,2MDSR@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1477420_1 518766.Rmar_1439 3.135e-265 833.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_1439|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_1477420_3 518766.Rmar_1438 3.173e-232 733.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_1438|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_1477420_28 518766.Rmar_1437 1.883e-41 164.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_1437|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_1477420_13 234267.Acid_0432 1.335e-124 416.0 COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria 57723|Acidobacteria C NapC/NirT cytochrome c family, N-terminal region - - - - - - - - - - - - Cytochrom_NNT CMS2_k127_1477420_2 1121875.KB907550_gene802 2.47e-243 758.0 COG4948@1|root,COG4948@2|Bacteria,4NE9A@976|Bacteroidetes,1IITY@117743|Flavobacteriia 976|Bacteroidetes M Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N CMS2_k127_1477420_33 1123278.KB893576_gene1365 2.358e-32 132.0 2AB14@1|root,310ER@2|Bacteria,4NNNB@976|Bacteroidetes,47Q4B@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_1477420_7 1121904.ARBP01000009_gene4400 2.289e-156 504.0 COG0385@1|root,COG0385@2|Bacteria,4NEIM@976|Bacteroidetes,47JSH@768503|Cytophagia 976|Bacteroidetes S PFAM Bile acid sodium symporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF CMS2_k127_1477420_12 1121875.KB907550_gene801 3.256e-133 430.0 COG0684@1|root,COG0684@2|Bacteria,4NF3M@976|Bacteroidetes,1HYXI@117743|Flavobacteriia 976|Bacteroidetes H Aldolase/RraA - - - - - - - - - - - - RraA-like CMS2_k127_1477420_14 1168034.FH5T_21220 2.793e-121 396.0 COG0667@1|root,COG0667@2|Bacteria,4NP8D@976|Bacteroidetes,2FTGW@200643|Bacteroidia 976|Bacteroidetes C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS2_k127_1477420_10 388413.ALPR1_18243 2.459e-140 460.0 COG2942@1|root,COG2942@2|Bacteria,4NEH7@976|Bacteroidetes,47P5Q@768503|Cytophagia 976|Bacteroidetes G N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) - - 5.1.3.11 ko:K16213 - - R01445,R10810 RC00289 ko00000,ko01000 - - - GlcNAc_2-epim CMS2_k127_1477420_34 1163408.UU9_03772 2.158e-28 127.0 COG1082@1|root,COG1082@2|Bacteria,1RAC3@1224|Proteobacteria,1RS39@1236|Gammaproteobacteria,1X6BI@135614|Xanthomonadales 135614|Xanthomonadales G xylose isomerase - - - - - - - - - - - - AP_endonuc_2 CMS2_k127_1477420_38 234267.Acid_2305 2.511e-15 80.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZC@57723|Acidobacteria 57723|Acidobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR CMS2_k127_1477420_9 861299.J421_1266 1.79e-143 489.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_1266|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_1477420_36 485913.Krac_5098 2.343e-26 113.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_1477420_6 251221.35211983 1.874e-176 585.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_1477420_39 1408473.JHXO01000006_gene1314 1.9e-12 78.0 COG4372@1|root,COG4372@2|Bacteria,4NMT7@976|Bacteroidetes,2FNI1@200643|Bacteroidia 976|Bacteroidetes S Transposase - - - - - - - - - - - - - CMS2_k127_1477420_35 573413.Spirs_1160 9.307e-27 115.0 COG0454@1|root,COG0456@2|Bacteria,2JB1N@203691|Spirochaetes 203691|Spirochaetes K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 CMS2_k127_1477420_19 639030.JHVA01000001_gene1905 4.096e-71 259.0 COG2271@1|root,COG2271@2|Bacteria,3Y3NG@57723|Acidobacteria,2JINU@204432|Acidobacteriia 2|Bacteria G Major Facilitator Superfamily - - - ko:K03535 - - - - ko00000,ko02000 2.A.1.14.1 - - MFS_1 CMS2_k127_1477420_25 1125863.JAFN01000001_gene586 1.598e-51 203.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria 28221|Deltaproteobacteria E extracellular solute-binding protein, family 5 - - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 CMS2_k127_1477420_22 1123371.ATXH01000006_gene861 3.389e-58 223.0 COG0747@1|root,COG0747@2|Bacteria,2GHG2@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 CMS2_k127_1477420_24 1125863.JAFN01000001_gene586 7.771e-57 218.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria 28221|Deltaproteobacteria E extracellular solute-binding protein, family 5 - - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 CMS2_k127_1477420_32 502025.Hoch_4611 2.86e-35 153.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria 28221|Deltaproteobacteria E extracellular solute-binding protein, family 5 - - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 CMS2_k127_1477420_17 517418.Ctha_1639 7.589e-99 332.0 COG0601@1|root,COG0601@2|Bacteria,1FDDB@1090|Chlorobi 1090|Chlorobi P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS2_k127_1487435_14 335543.Sfum_1620 2.821e-152 495.0 COG0683@1|root,COG0683@2|Bacteria 2|Bacteria E ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 CMS2_k127_1487435_10 335543.Sfum_1621 7.066e-172 546.0 COG3292@1|root,COG3292@2|Bacteria,1QU1S@1224|Proteobacteria,42WTY@68525|delta/epsilon subdivisions,2WSR0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM Two component regulator propeller - - - - - - - - - - - - CarboxypepD_reg,PKD,Peptidase_C13,Reg_prop CMS2_k127_1487435_0 335543.Sfum_1622 0.0 1150.0 COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42XD8@68525|delta/epsilon subdivisions,2WT8U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Cytochrom_C,Cytochrome_C554 CMS2_k127_1487435_3 335543.Sfum_1623 3.666e-217 686.0 COG3118@1|root,COG3118@2|Bacteria,1PQ8G@1224|Proteobacteria 1224|Proteobacteria O ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS CMS2_k127_1487435_15 335543.Sfum_1624 3.864e-148 493.0 COG0823@1|root,COG0823@2|Bacteria,1PFBB@1224|Proteobacteria,432XJ@68525|delta/epsilon subdivisions,2WXKI@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - - CMS2_k127_1487435_30 479434.Sthe_1870 1.01e-109 362.0 COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi,27XKF@189775|Thermomicrobia 189775|Thermomicrobia E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 CMS2_k127_1487435_11 335543.Sfum_1623 8.399e-170 550.0 COG3118@1|root,COG3118@2|Bacteria,1PQ8G@1224|Proteobacteria 1224|Proteobacteria O ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS CMS2_k127_1487435_80 880072.Desac_1318 3.935e-14 82.0 COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM Cyclic nucleotide-binding fnr-1 - - ko:K01420,ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding CMS2_k127_1487435_52 251229.Chro_4000 2.632e-65 234.0 COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,3VK4S@52604|Pleurocapsales 1117|Cyanobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP CMS2_k127_1487435_9 1278073.MYSTI_00528 4.632e-172 554.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2YWP2@29|Myxococcales 28221|Deltaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsA - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N CMS2_k127_1487435_75 765911.Thivi_1400 1.011e-23 112.0 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,1X17B@135613|Chromatiales 135613|Chromatiales S Tellurite resistance protein TerB - - - - - - - - - - - - TerB CMS2_k127_1487435_68 1410618.JNKI01000009_gene50 4.652e-34 147.0 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,4H3GM@909932|Negativicutes 909932|Negativicutes D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C CMS2_k127_1487435_56 1379270.AUXF01000005_gene655 2.623e-60 213.0 COG0634@1|root,COG0634@2|Bacteria,1ZTH7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Phosphoribosyl transferase domain - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran CMS2_k127_1487435_2 861299.J421_3042 2.96e-258 811.0 COG0465@1|root,COG0465@2|Bacteria,1ZSRI@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,Peptidase_M41 CMS2_k127_1487435_51 861299.J421_3043 1.404e-66 245.0 COG0294@1|root,COG0294@2|Bacteria 2|Bacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8 ko:K00796,ko:K00950,ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503,R03504,R11037,R11073 RC00002,RC00017,RC00121,RC00721,RC00842,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3924,iPC815.YPO3501 Pterin_bind CMS2_k127_1487435_46 861299.J421_3044 2.691e-73 257.0 COG1624@1|root,COG1624@2|Bacteria,1ZUI8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N CMS2_k127_1487435_37 861299.J421_2988 7.671e-86 313.0 COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_1487435_59 1379270.AUXF01000005_gene658 7.617e-54 197.0 COG0325@1|root,COG0325@2|Bacteria,1ZTJZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N CMS2_k127_1487435_76 379066.GAU_1397 1.231e-19 98.0 COG3599@1|root,COG3599@2|Bacteria,1ZUSD@142182|Gemmatimonadetes 142182|Gemmatimonadetes D DivIVA protein - - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA CMS2_k127_1487435_24 1379270.AUXF01000005_gene660 1.247e-119 389.0 COG0005@1|root,COG0005@2|Bacteria,1ZUII@142182|Gemmatimonadetes 142182|Gemmatimonadetes F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate - - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 CMS2_k127_1487435_1 861299.J421_3048 1.935e-309 983.0 COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 CMS2_k127_1487435_57 861299.J421_3049 1.462e-59 209.0 COG1734@1|root,COG1734@2|Bacteria,1ZTP9@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR CMS2_k127_1487435_61 379066.GAU_1401 1.227e-43 169.0 COG0597@1|root,COG0597@2|Bacteria,1ZTWA@142182|Gemmatimonadetes 142182|Gemmatimonadetes M This protein specifically catalyzes the removal of signal peptides from prolipoproteins - - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 CMS2_k127_1487435_42 1379270.AUXF01000005_gene665 2.125e-81 283.0 COG0564@1|root,COG0564@2|Bacteria,1ZSXN@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Responsible for synthesis of pseudouridine from uracil - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 CMS2_k127_1487435_83 1191523.MROS_2192 8.142e-09 63.0 COG0835@1|root,COG0835@2|Bacteria 2|Bacteria NT chemotaxis cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW CMS2_k127_1487435_55 1379270.AUXF01000005_gene667 1.329e-60 210.0 COG2204@1|root,COG2204@2|Bacteria,1ZTMH@142182|Gemmatimonadetes 142182|Gemmatimonadetes T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg CMS2_k127_1487435_17 379066.GAU_1406 1.034e-138 465.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1ZT7R@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT P2 response regulator binding domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 CMS2_k127_1487435_53 379066.GAU_1407 1.18e-63 224.0 COG1776@1|root,COG1776@2|Bacteria,1ZTIW@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT CheC-like family - - - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC CMS2_k127_1487435_23 861299.J421_3057 1.743e-120 419.0 COG0457@1|root,COG0457@2|Bacteria,1ZSS6@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 CMS2_k127_1487435_67 316274.Haur_0845 1.716e-34 147.0 COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi,374ST@32061|Chloroflexia 32061|Chloroflexia S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388 CMS2_k127_1487435_90 1110502.TMO_0445 0.0002994 52.0 COG0457@1|root,COG0457@2|Bacteria,1N0DE@1224|Proteobacteria,2UCGA@28211|Alphaproteobacteria,2JTE7@204441|Rhodospirillales 204441|Rhodospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_2 CMS2_k127_1487435_88 868131.MSWAN_1706 2.134e-05 51.0 COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota 28890|Euryarchaeota S Roadblock LC7 family protein - GO:0001101,GO:0003674,GO:0005085,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009719,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0019899,GO:0023051,GO:0023056,GO:0032006,GO:0032008,GO:0032947,GO:0042221,GO:0043200,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051716,GO:0065007,GO:0065009,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0098772,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 - ko:K07131 - - - - ko00000 - - - Robl_LC7 CMS2_k127_1487435_84 379066.GAU_1115 3.317e-06 57.0 COG2018@1|root,COG2018@2|Bacteria,1ZTK7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Roadblock/LC7 domain - - - - - - - - - - - - Robl_LC7 CMS2_k127_1487435_43 861299.J421_3059 2.689e-80 271.0 COG1100@1|root,COG1100@2|Bacteria,1ZTK3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Small GTP-binding protein - - - ko:K06883 - - - - ko00000 - - - Arf CMS2_k127_1487435_47 379066.GAU_1411 2.01e-72 269.0 COG0593@1|root,COG0593@2|Bacteria,1ZUFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bacterial dnaA protein - - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA CMS2_k127_1487435_19 1379270.AUXF01000005_gene674 1.439e-136 455.0 COG0457@1|root,COG0457@2|Bacteria,1ZSPN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388,TPR_16,TPR_2 CMS2_k127_1487435_50 861299.J421_3062 8.8e-67 236.0 COG1352@1|root,COG1352@2|Bacteria 2|Bacteria NT protein-glutamate O-methyltransferase activity cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N CMS2_k127_1487435_71 379066.GAU_1413 5.462e-27 120.0 COG1871@1|root,COG1871@2|Bacteria,1ZV29@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis - - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD CMS2_k127_1487435_41 379066.GAU_1414 1.143e-83 293.0 COG2201@1|root,COG2201@2|Bacteria,1ZUFV@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg CMS2_k127_1487435_85 530564.Psta_2068 6.563e-06 57.0 COG0835@1|root,COG0835@2|Bacteria,2IZN1@203682|Planctomycetes 203682|Planctomycetes NT CheW domain protein - - - - - - - - - - - - CheW CMS2_k127_1487435_72 1121451.DESAM_22267 2.463e-24 108.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X5TT@28221|Deltaproteobacteria,2MGVV@213115|Desulfovibrionales 28221|Deltaproteobacteria NT Two component signalling adaptor domain cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW CMS2_k127_1487435_35 1379270.AUXF01000005_gene678 3.766e-87 297.0 COG0457@1|root,COG0457@2|Bacteria,1ZTK5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2 CMS2_k127_1487435_64 861299.J421_3065 6.315e-41 163.0 2DUTE@1|root,33S5W@2|Bacteria,1ZSMI@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1487435_92 1379270.AUXF01000005_gene680 0.0009594 44.0 2DENK@1|root,2ZNKE@2|Bacteria,1ZV91@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1487435_89 1128421.JAGA01000002_gene667 5.877e-05 56.0 COG0457@1|root,COG5635@1|root,COG0457@2|Bacteria,COG5635@2|Bacteria 2|Bacteria T Nacht domain - - - - - - - - - - - - NACHT,TPR_16,TPR_19,TPR_2,TPR_8,Trypsin_2 CMS2_k127_1487435_38 379066.GAU_1420 3.454e-85 293.0 COG0275@1|root,COG0275@2|Bacteria,1ZT4V@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 CMS2_k127_1487435_29 861299.J421_3070 9.503e-114 390.0 COG0768@1|root,COG0768@2|Bacteria,1ZSYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Penicillin binding protein transpeptidase domain - - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase CMS2_k127_1487435_16 861299.J421_3071 1.833e-139 458.0 COG0769@1|root,COG0769@2|Bacteria,1ZSS3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M CMS2_k127_1487435_39 379066.GAU_1424 6.116e-85 298.0 COG0770@1|root,COG0770@2|Bacteria,1ZT1U@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M CMS2_k127_1487435_18 861299.J421_3073 5.572e-137 446.0 COG0472@1|root,COG0472@2|Bacteria,1ZT4Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4 CMS2_k127_1487435_22 861299.J421_3074 3.334e-127 421.0 COG0771@1|root,COG0771@2|Bacteria,1ZT38@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M CMS2_k127_1487435_34 861299.J421_3075 1.142e-88 306.0 COG0772@1|root,COG0772@2|Bacteria,1ZSXI@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell cycle protein - - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE CMS2_k127_1487435_36 379066.GAU_1428 2.069e-86 302.0 COG0707@1|root,COG0707@2|Bacteria,1ZSW5@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 CMS2_k127_1487435_27 1379270.AUXF01000005_gene691 9.082e-116 388.0 COG0773@1|root,COG0773@2|Bacteria,1ZSQG@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M CMS2_k127_1487435_73 861299.J421_3078 3.971e-24 111.0 COG1589@1|root,COG1589@2|Bacteria,1ZTRX@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell division protein FtsQ - - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - POTRA_1 CMS2_k127_1487435_20 861299.J421_3079 8.247e-134 438.0 COG0849@1|root,COG0849@2|Bacteria,1ZSRE@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA CMS2_k127_1487435_7 861299.J421_3080 3.469e-173 550.0 COG0206@1|root,COG0206@2|Bacteria,1ZSNH@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin CMS2_k127_1487435_54 1323663.AROI01000013_gene273 6.094e-62 230.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 CMS2_k127_1487435_65 1207063.P24_02601 2.175e-40 160.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria,2JPAY@204441|Rhodospirillales 204441|Rhodospirillales E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,His_biosynth CMS2_k127_1487435_60 861299.J421_3082 2.487e-51 204.0 COG1572@1|root,COG1572@2|Bacteria,1ZSTW@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - - CMS2_k127_1487435_33 1379270.AUXF01000005_gene698 3.619e-90 306.0 COG0552@1|root,COG0552@2|Bacteria,1ZTBT@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N CMS2_k127_1487435_8 1379698.RBG1_1C00001G0402 2.694e-172 563.0 COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria 2|Bacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge CMS2_k127_1487435_66 237368.SCABRO_00501 2.258e-39 150.0 COG2154@1|root,COG2154@2|Bacteria,2J0CT@203682|Planctomycetes 203682|Planctomycetes H PFAM Pterin 4 alpha carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a CMS2_k127_1487435_5 1379270.AUXF01000005_gene701 5.161e-184 587.0 COG0017@1|root,COG0017@2|Bacteria,1ZSTX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class II (D, K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon CMS2_k127_1487435_49 861299.J421_3092 3.807e-69 242.0 COG1694@1|root,COG3956@2|Bacteria,1ZSZH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S MazG nucleotide pyrophosphohydrolase domain - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - MazG CMS2_k127_1487435_45 861299.J421_3093 1.381e-74 264.0 COG0787@1|root,COG0787@2|Bacteria,1ZT57@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids - - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N CMS2_k127_1487435_31 370438.PTH_1211 1.372e-103 349.0 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,260HR@186807|Peptococcaceae 186801|Clostridia G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme CMS2_k127_1487435_69 1379270.AUXF01000005_gene705 5.799e-32 131.0 COG0295@1|root,COG0295@2|Bacteria,1ZTZY@142182|Gemmatimonadetes 142182|Gemmatimonadetes F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis - - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 CMS2_k127_1487435_81 1379270.AUXF01000005_gene706 1.041e-11 77.0 2F0K0@1|root,33TNP@2|Bacteria,1ZTJU@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1487435_70 379066.GAU_1453 9.26e-30 134.0 2EYUI@1|root,33S1Q@2|Bacteria,1ZTHR@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1487435_48 671143.DAMO_1213 3.285e-70 258.0 COG0621@1|root,COG0621@2|Bacteria,2NP2U@2323|unclassified Bacteria 2|Bacteria J Uncharacterized protein family UPF0004 yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 CMS2_k127_1487435_12 861299.J421_3101 2.44e-161 520.0 COG0621@1|root,COG0621@2|Bacteria,1ZT0Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 CMS2_k127_1487435_82 643648.Slip_0652 2.293e-09 63.0 2DNY2@1|root,32ZR4@2|Bacteria,1VEGZ@1239|Firmicutes,24RGC@186801|Clostridia,42K6V@68298|Syntrophomonadaceae 186801|Clostridia S Late competence development protein ComFB comFB - - ko:K02241 - M00429 - - ko00000,ko00002,ko02044 - - - ComFB CMS2_k127_1487435_44 379066.GAU_1455 2.875e-79 292.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1ZSMY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Competence protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,Lactamase_B CMS2_k127_1487435_25 379066.GAU_1456 3.701e-119 391.0 COG0158@1|root,COG0158@2|Bacteria,1ZTAZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Fructose-1-6-bisphosphatase, N-terminal domain fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase CMS2_k127_1487435_4 861299.J421_3107 1.222e-205 653.0 COG1884@1|root,COG1884@2|Bacteria,1ZT5I@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase CMS2_k127_1487435_77 1379698.RBG1_1C00001G1439 1.287e-18 89.0 COG2331@1|root,COG2331@2|Bacteria,2NQ36@2323|unclassified Bacteria 2|Bacteria S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 CMS2_k127_1487435_13 1118054.CAGW01000043_gene1092 2.005e-158 517.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,26R9D@186822|Paenibacillaceae 91061|Bacilli J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d CMS2_k127_1487435_28 1379270.AUXF01000005_gene720 4.824e-114 375.0 COG0524@1|root,COG0524@2|Bacteria,1ZSUT@142182|Gemmatimonadetes 142182|Gemmatimonadetes G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB CMS2_k127_1487435_32 1379270.AUXF01000005_gene721 7.884e-103 344.0 COG0150@1|root,COG0150@2|Bacteria,1ZSQJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F AIR synthase related protein, C-terminal domain purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS2_k127_1487435_40 861299.J421_3114 1.781e-84 292.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1ZSNI@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate - - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 CMS2_k127_1487435_58 861299.J421_3115 1.169e-56 204.0 COG0307@1|root,COG0307@2|Bacteria,1ZTQM@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Lumazine binding domain - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding CMS2_k127_1487435_6 861299.J421_3116 3.245e-179 570.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1ZT7J@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 CMS2_k127_1487435_62 861299.J421_3117 1.94e-43 163.0 COG0054@1|root,COG0054@2|Bacteria,1ZTPU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase CMS2_k127_1487435_74 861299.J421_3118 5.704e-24 109.0 COG0781@1|root,COG0781@2|Bacteria,1ZTRU@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB CMS2_k127_1487435_21 861299.J421_3119 3.322e-127 418.0 COG0438@1|root,COG0438@2|Bacteria,1ZTBC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS2_k127_1487435_91 1035308.AQYY01000001_gene3168 0.0006797 48.0 COG1544@1|root,COG1544@2|Bacteria 2|Bacteria J regulation of translation hpf GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE CMS2_k127_1487435_26 379066.GAU_1477 1.417e-118 389.0 COG1493@1|root,COG1493@2|Bacteria,1ZSY3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N CMS2_k127_1487435_79 379066.GAU_1478 3.806e-15 80.0 COG2893@1|root,COG2893@2|Bacteria,1ZU41@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system fructose IIA component - - - ko:K02744 ko00052,ko02060,map00052,map02060 M00277,M00287 R08366,R08367 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1.4,4.A.6.1.5 - - EIIA-man CMS2_k127_1487435_63 379066.GAU_1479 1.352e-41 160.0 COG3444@1|root,COG3444@2|Bacteria,1ZTQR@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system sorbose subfamily IIB component - - - ko:K19507 ko02060,map02060 M00764 - - ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1.19 - - PTSIIB_sorb CMS2_k127_1487435_78 861299.J421_3124 1.66e-16 89.0 COG3715@1|root,COG3715@2|Bacteria,1ZTVH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system sorbose-specific iic component - - - ko:K02795 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EII-Sor CMS2_k127_1487435_87 379066.GAU_1481 1.996e-05 51.0 COG3716@1|root,COG3716@2|Bacteria,1ZTJH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system mannose/fructose/sorbose family IID component - - - ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EIID-AGA CMS2_k127_1498357_2 761193.Runsl_2121 6.229e-159 534.0 COG1629@1|root,COG1629@2|Bacteria,4NF88@976|Bacteroidetes,47JEF@768503|Cytophagia 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 CMS2_k127_1498357_5 1347342.BN863_3110 8.945e-21 102.0 28J3Q@1|root,2Z8ZW@2|Bacteria,4NGJW@976|Bacteroidetes,1HZI5@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (Porph_ging) - - - - - - - - - - - - Porph_ging CMS2_k127_1498357_3 927658.AJUM01000034_gene439 2.132e-96 323.0 COG2133@1|root,COG2133@2|Bacteria,4NGMS@976|Bacteroidetes,2FQQN@200643|Bacteroidia 976|Bacteroidetes G Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 CMS2_k127_1498357_1 1121904.ARBP01000006_gene3743 7.52e-169 542.0 COG0673@1|root,COG0673@2|Bacteria,4NGGS@976|Bacteroidetes,47JH2@768503|Cytophagia 976|Bacteroidetes S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS2_k127_1498357_0 694427.Palpr_0579 0.0 1171.0 COG3250@1|root,COG3250@2|Bacteria,4NKZX@976|Bacteroidetes,2FNTC@200643|Bacteroidia,22ZRF@171551|Porphyromonadaceae 976|Bacteroidetes G Concanavalin A-like lectin/glucanases superfamily - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3 CMS2_k127_1498357_6 1232446.BAIE02000043_gene2349 8.633e-15 85.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - - - - - - - - - - Lactamase_B CMS2_k127_1498357_4 243090.RB2092 1.457e-86 295.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2 CMS2_k127_1501090_10 382464.ABSI01000010_gene3739 7.909e-94 320.0 COG0330@1|root,COG0330@2|Bacteria,46VDU@74201|Verrucomicrobia 74201|Verrucomicrobia O prohibitin homologues - - - - - - - - - - - - Band_7 CMS2_k127_1501090_16 234267.Acid_1594 5.352e-40 151.0 COG1725@1|root,COG1725@2|Bacteria,3Y5VN@57723|Acidobacteria 57723|Acidobacteria K helix_turn_helix gluconate operon transcriptional repressor - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR CMS2_k127_1501090_3 338969.Rfer_0863 1.539e-248 787.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHII@28216|Betaproteobacteria,4AJXE@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding - - 1.3.99.16 ko:K00256 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 CMS2_k127_1501090_14 338969.Rfer_0864 3.386e-57 206.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VRBT@28216|Betaproteobacteria,4AE1V@80864|Comamonadaceae 28216|Betaproteobacteria C 2Fe-2S -binding domain protein iorA - 1.17.2.1 ko:K18029 ko00760,ko01120,map00760,map01120 M00622 R09473 RC00589 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Fer2_2 CMS2_k127_1501090_7 479434.Sthe_2544 3.087e-143 469.0 COG0477@1|root,COG2211@1|root,COG0477@2|Bacteria,COG2211@2|Bacteria,2G5J9@200795|Chloroflexi,27Y0E@189775|Thermomicrobia 189775|Thermomicrobia P Fungal trichothecene efflux pump (TRI12) - - - - - - - - - - - - MFS_1 CMS2_k127_1501090_4 909663.KI867150_gene79 1.456e-229 724.0 COG4868@1|root,COG4868@2|Bacteria,1NN03@1224|Proteobacteria,42P46@68525|delta/epsilon subdivisions,2WKVV@28221|Deltaproteobacteria,2MR6J@213462|Syntrophobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF1846) - - - - - - - - - - - - DUF1846 CMS2_k127_1501090_5 927658.AJUM01000024_gene2560 3.314e-183 585.0 COG3669@1|root,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,2FM8D@200643|Bacteroidia,3XJA3@558415|Marinilabiliaceae 976|Bacteroidetes G Alpha-L-fucosidase C-terminal domain - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Fucosidase_C CMS2_k127_1501090_15 1396141.BATP01000003_gene4881 8.805e-45 173.0 COG3568@1|root,COG3568@2|Bacteria,46X7C@74201|Verrucomicrobia,2IUUK@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos CMS2_k127_1501090_17 195250.CM001776_gene1433 1.283e-34 146.0 COG0667@1|root,COG0667@2|Bacteria,1G2DX@1117|Cyanobacteria,1H2H4@1129|Synechococcus 1117|Cyanobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS2_k127_1501090_8 861299.J421_2340 1.72e-116 387.0 COG1158@1|root,COG1158@2|Bacteria,1ZTA0@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_RNA_bind CMS2_k127_1501090_23 1379698.RBG1_1C00001G1358 3.302e-09 67.0 COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria 2|Bacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C CMS2_k127_1501090_2 504472.Slin_3267 4.311e-315 980.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NFTM@976|Bacteroidetes,47NS1@768503|Cytophagia 976|Bacteroidetes EU Dienelactone hydrolase family - - - - - - - - - - - - DPPIV_N,PD40,Peptidase_S9 CMS2_k127_1501090_19 1185876.BN8_04332 7.31e-29 122.0 COG2866@1|root,COG2866@2|Bacteria,4NF3D@976|Bacteroidetes,47UEQ@768503|Cytophagia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS2_k127_1501090_9 309801.trd_0392 4.353e-99 334.0 COG0626@1|root,COG0626@2|Bacteria,2G684@200795|Chloroflexi,27Y2Y@189775|Thermomicrobia 189775|Thermomicrobia E Cys/Met metabolism PLP-dependent enzyme - - 2.5.1.48,4.4.1.11 ko:K01739,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP CMS2_k127_1501090_6 1047013.AQSP01000105_gene1439 4.344e-154 500.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid MA20_31530 - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS2_k127_1501090_11 1047013.AQSP01000097_gene1961 2.419e-79 270.0 COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria 2|Bacteria S Methyltransferase domain mdmC - - - - - - - - - - - Methyltransf_24,Methyltransf_3 CMS2_k127_1501090_21 44251.PDUR_14565 3.419e-22 102.0 2BFBG@1|root,3294J@2|Bacteria,1V87V@1239|Firmicutes,4HDIB@91061|Bacilli 91061|Bacilli S Domain of unknown function (DUF4405) - - - - - - - - - - - - DUF4405 CMS2_k127_1501090_20 1459636.NTE_00025 3.928e-25 122.0 arCOG07536@1|root,arCOG07536@2157|Archaea,41SZB@651137|Thaumarchaeota 651137|Thaumarchaeota S Galactose oxidase, central domain - - - - - - - - - - - - Kelch_1 CMS2_k127_1501090_0 251221.35211322 0.0 1155.0 COG2866@1|root,COG2866@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS2_k127_1501090_1 861299.J421_0588 1.365e-316 1002.0 COG4447@1|root,COG4447@2|Bacteria,1ZSRH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 CMS2_k127_1501090_13 1267533.KB906733_gene3362 7.311e-64 242.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C CMS2_k127_1501090_18 1379270.AUXF01000002_gene1600 2.144e-33 148.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_1501090_12 1379270.AUXF01000007_gene994 2.043e-64 223.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_1501090_22 234267.Acid_4839 2.757e-18 89.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_1612787_0 383372.Rcas_1863 2.151e-308 953.0 COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi,376PZ@32061|Chloroflexia 32061|Chloroflexia C PFAM aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N CMS2_k127_1612787_10 383372.Rcas_1862 3.492e-16 83.0 COG1977@1|root,COG1977@2|Bacteria,2G9DU@200795|Chloroflexi,377DC@32061|Chloroflexia 32061|Chloroflexia H TIGRFAM MoaD family protein - - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS CMS2_k127_1612787_1 926550.CLDAP_40590 2.597e-174 559.0 COG0535@1|root,COG2002@1|root,COG0535@2|Bacteria,COG2002@2|Bacteria,2G75Y@200795|Chloroflexi 200795|Chloroflexi C Iron-sulfur cluster-binding domain - - - - - - - - - - - - Fer4_14,Radical_SAM,SPASM CMS2_k127_1612787_8 240015.ACP_1304 9.526e-28 118.0 COG3547@1|root,COG3547@2|Bacteria,3Y52I@57723|Acidobacteria,2JMUS@204432|Acidobacteriia 204432|Acidobacteriia L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 CMS2_k127_1612787_14 1121949.AQXT01000002_gene2910 0.0002017 51.0 COG4319@1|root,COG4319@2|Bacteria,1PZUG@1224|Proteobacteria,2V19B@28211|Alphaproteobacteria,44001@69657|Hyphomonadaceae 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS2_k127_1612787_13 292.DM42_6990 2.919e-06 57.0 COG4319@1|root,COG4319@2|Bacteria,1PIQT@1224|Proteobacteria,2W7AE@28216|Betaproteobacteria,1KE6X@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 CMS2_k127_1612787_9 1265505.ATUG01000002_gene1876 2.4e-16 89.0 COG0509@1|root,COG0509@2|Bacteria,1NRFW@1224|Proteobacteria,42ZAN@68525|delta/epsilon subdivisions,2WUQI@28221|Deltaproteobacteria,2MMY2@213118|Desulfobacterales 28221|Deltaproteobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H CMS2_k127_1612787_4 1121920.AUAU01000012_gene2649 9.836e-78 269.0 COG0437@1|root,COG0437@2|Bacteria,3Y5RE@57723|Acidobacteria 57723|Acidobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11 CMS2_k127_1612787_3 204669.Acid345_2602 2.786e-127 426.0 COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria 57723|Acidobacteria C Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD CMS2_k127_1612787_5 58344.JOEL01000016_gene5882 1.877e-60 226.0 COG1228@1|root,COG1228@2|Bacteria 2|Bacteria Q imidazolonepropionase activity - - 3.5.2.18 ko:K15358 ko00760,ko01120,map00760,map01120 - R07984 RC01933 ko00000,ko00001,ko01000 - - - Amidohydro_1,Amidohydro_3 CMS2_k127_1612787_7 927658.AJUM01000037_gene2352 2.061e-43 171.0 COG0823@1|root,COG0823@2|Bacteria,4NIV7@976|Bacteroidetes,2FZ2H@200643|Bacteroidia,3XIUF@558415|Marinilabiliaceae 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_1612787_2 317655.Sala_2616 4.585e-156 500.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,2TT3J@28211|Alphaproteobacteria,2K3BR@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF4172) - - - - - - - - - - - - DUF4172,Fic CMS2_k127_1612787_6 1499967.BAYZ01000090_gene4936 8.408e-54 201.0 COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria 2|Bacteria U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS2_k127_1612787_11 1379270.AUXF01000001_gene2088 5.188e-12 73.0 2DDI2@1|root,2ZI6I@2|Bacteria,1ZVAF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_161962_6 1121380.JNIW01000043_gene1045 0.0002207 45.0 COG0507@1|root,COG0507@2|Bacteria 2|Bacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - AAA_30,HTH_31,N_BRCA1_IG CMS2_k127_161962_3 1392488.JHZY01000004_gene1693 1.637e-15 85.0 2EVE1@1|root,33NUE@2|Bacteria,4NYCD@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_161962_4 861299.J421_3012 5.104e-05 51.0 COG2919@1|root,COG2919@2|Bacteria,1ZU6R@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Septum formation initiator - - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC CMS2_k127_161962_0 861299.J421_3011 2.444e-187 594.0 COG0148@1|root,COG0148@2|Bacteria,1ZTAB@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N CMS2_k127_161962_2 861299.J421_3010 2.824e-49 187.0 COG0204@1|root,COG0204@2|Bacteria,1ZT6D@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase CMS2_k127_161962_1 861299.J421_3009 2.024e-69 247.0 COG0611@1|root,COG0611@2|Bacteria,1ZTIU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS2_k127_161962_5 743720.Psefu_0912 9.136e-05 53.0 COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,1QU1S@1224|Proteobacteria,1T1MB@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,Reg_prop,Y_Y_Y CMS2_k127_1632508_18 1379270.AUXF01000002_gene1173 4.084e-16 94.0 COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,1ZTYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Leishmanolysin - - - - - - - - - - - - Peptidase_M8 CMS2_k127_1632508_14 196162.Noca_4928 1.845e-31 142.0 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2IDNX@201174|Actinobacteria,4DTRZ@85009|Propionibacteriales 201174|Actinobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD CMS2_k127_1632508_11 861299.J421_1231 1.485e-58 232.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1231|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_1632508_4 861299.J421_2988 7.425e-158 526.0 COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_1632508_2 861299.J421_2989 1.009e-188 602.0 COG0138@1|root,COG0138@2|Bacteria,1ZT6N@142182|Gemmatimonadetes 142182|Gemmatimonadetes F AICARFT/IMPCHase bienzyme purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS CMS2_k127_1632508_10 861299.J421_2990 8.406e-60 214.0 COG0299@1|root,COG0299@2|Bacteria,1ZTKJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N CMS2_k127_1632508_19 82654.Pse7367_2113 1.43e-15 87.0 COG0265@1|root,COG0265@2|Bacteria,1G0XN@1117|Cyanobacteria,1H8PC@1150|Oscillatoriales 1117|Cyanobacteria O COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PPC,Trypsin_2 CMS2_k127_1632508_7 243231.GSU3369 2.343e-117 395.0 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,43S0Q@69541|Desulfuromonadales 28221|Deltaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA CMS2_k127_1632508_12 379066.GAU_1282 2.357e-51 205.0 COG2372@1|root,COG2372@2|Bacteria,1ZTUI@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bacterial Ig-like domain - - - - - - - - - - - - Big_5 CMS2_k127_1632508_0 861299.J421_2994 2.616e-297 937.0 COG0525@1|root,COG0525@2|Bacteria,1ZSXQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 CMS2_k127_1632508_20 861299.J421_2996 6.007e-07 57.0 2FBQ3@1|root,343V1@2|Bacteria,1ZU1R@142182|Gemmatimonadetes 142182|Gemmatimonadetes S BON domain - - - - - - - - - - - - BON CMS2_k127_1632508_1 861299.J421_2997 2.112e-204 657.0 COG0441@1|root,COG0441@2|Bacteria,1ZT2I@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD CMS2_k127_1632508_3 861299.J421_3000 3.034e-165 527.0 COG0183@1|root,COG0183@2|Bacteria,1ZTGX@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS2_k127_1632508_16 401053.AciPR4_1940 2.884e-23 109.0 COG1266@1|root,COG1266@2|Bacteria,3Y4ED@57723|Acidobacteria,2JJ3Q@204432|Acidobacteriia 204432|Acidobacteriia S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS2_k127_1632508_8 880073.Calab_0217 3.915e-115 385.0 COG1250@1|root,COG1250@2|Bacteria,2NP11@2323|unclassified Bacteria 2|Bacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain hbdA - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N CMS2_k127_1632508_5 861299.J421_3003 1.985e-141 459.0 COG1960@1|root,COG1960@2|Bacteria,1ZSRC@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS2_k127_1632508_6 861299.J421_3004 5.571e-140 455.0 COG0334@1|root,COG0334@2|Bacteria,1ZTBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS2_k127_1632508_13 379066.GAU_1296 2.553e-36 141.0 2E5IJ@1|root,3309Y@2|Bacteria,1ZTU3@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1632508_15 861299.J421_3007 1.255e-26 110.0 2EQ8R@1|root,33HV0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_1632508_9 861299.J421_3008 6.273e-76 274.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1ZTAT@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N CMS2_k127_1632508_17 1379270.AUXF01000005_gene603 1.75e-16 91.0 COG3292@1|root,COG3292@2|Bacteria,1ZUSW@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Two component regulator propeller - - - - - - - - - - - - - CMS2_k127_166375_0 344747.PM8797T_07207 2.969e-285 900.0 COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes 203682|Planctomycetes L AAA-like domain - - - - - - - - - - - - DUF853,DUF87,PDDEXK_1 CMS2_k127_166375_2 118163.Ple7327_4457 6.767e-137 443.0 COG0667@1|root,COG0667@2|Bacteria,1G1XV@1117|Cyanobacteria,3VIG5@52604|Pleurocapsales 1117|Cyanobacteria C PFAM Aldo keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS2_k127_166375_11 338969.Rfer_1209 5.361e-41 154.0 COG0537@1|root,COG0537@2|Bacteria,1N3EA@1224|Proteobacteria,2VSGA@28216|Betaproteobacteria,4AJE5@80864|Comamonadaceae 28216|Betaproteobacteria FG Scavenger mRNA decapping enzyme C-term binding - - - - - - - - - - - - HIT CMS2_k127_166375_16 861299.J421_2048 1.022e-07 59.0 COG0828@1|root,COG0828@2|Bacteria,1ZU81@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S21 - - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 CMS2_k127_166375_12 379066.GAU_2739 3.072e-27 117.0 COG1278@1|root,COG1278@2|Bacteria,1ZV0Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Ribonuclease B OB domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS2_k127_166375_4 880073.Calab_0513 6.958e-112 381.0 2C3GN@1|root,31EWU@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_166375_3 880073.Calab_2482 2.946e-125 414.0 COG0534@1|root,COG0534@2|Bacteria,2NPFE@2323|unclassified Bacteria 2|Bacteria V Mate efflux family protein - - - - - - - - - - - - ANKH,MatE CMS2_k127_166375_8 1121937.AUHJ01000009_gene1566 1.192e-59 217.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,468KZ@72275|Alteromonadaceae 1236|Gammaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL CMS2_k127_166375_10 292415.Tbd_2814 1.439e-50 192.0 COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1MZV7@1224|Proteobacteria,2WEG8@28216|Betaproteobacteria,1KS7W@119069|Hydrogenophilales 119069|Hydrogenophilales KT Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GGDEF CMS2_k127_166375_14 1112204.GPOL_c10920 5.057e-13 76.0 COG5473@1|root,COG5473@2|Bacteria,2GN5K@201174|Actinobacteria,4GF08@85026|Gordoniaceae 201174|Actinobacteria J Zn-ribbon protein possibly nucleic acid-binding - - - - - - - - - - - - - CMS2_k127_166375_9 1122604.JONR01000045_gene2500 3.699e-53 201.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1SZK5@1236|Gammaproteobacteria,1XCD9@135614|Xanthomonadales 135614|Xanthomonadales C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N CMS2_k127_166375_5 861299.J421_0510 2.225e-98 337.0 COG2220@1|root,COG2220@2|Bacteria,1ZUY2@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 CMS2_k127_166375_13 335541.Swol_0327 2.73e-15 84.0 COG2050@1|root,COG2050@2|Bacteria,1VXYK@1239|Firmicutes,251HM@186801|Clostridia 186801|Clostridia Q Thioesterase superfamily - - - - - - - - - - - - 4HBT CMS2_k127_166375_7 99598.Cal7507_4215 8.78e-84 286.0 COG4360@1|root,COG4360@2|Bacteria,1G2S9@1117|Cyanobacteria,1HIMD@1161|Nostocales 1117|Cyanobacteria F PFAM ATP adenylyltransferase apa2 - 2.7.7.53 ko:K00988 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - ATP_transf CMS2_k127_166375_6 1340493.JNIF01000003_gene3002 1.735e-97 333.0 COG1228@1|root,COG1228@2|Bacteria,3Y6WV@57723|Acidobacteria 57723|Acidobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS2_k127_166375_1 234267.Acid_6720 2.867e-151 491.0 COG1228@1|root,COG1228@2|Bacteria,3Y6Y2@57723|Acidobacteria 57723|Acidobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS2_k127_168182_9 886377.Murru_3392 2.008e-17 96.0 2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1HZN8@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 CMS2_k127_168182_10 368407.Memar_1212 1.986e-06 60.0 COG3291@1|root,arCOG02527@1|root,arCOG02508@2157|Archaea,arCOG02527@2157|Archaea 2157|Archaea G PFAM PKD domain containing protein - - - - - - - - - - - - Beta_helix,Big_2,Big_5,CHB_HEX_C_1,PKD,PMBR,PQQ_3,Peptidase_S9,Polysacc_deac_1 CMS2_k127_168182_3 593750.Metfor_2720 2.056e-86 297.0 COG1230@1|root,arCOG01477@2157|Archaea,2XV4R@28890|Euryarchaeota 28890|Euryarchaeota P Co Zn Cd efflux system component - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux,ZT_dimer CMS2_k127_168182_7 234267.Acid_1209 1.177e-52 193.0 COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria 57723|Acidobacteria K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF CMS2_k127_168182_2 1089550.ATTH01000001_gene1831 1.287e-117 399.0 COG0515@1|root,COG0515@2|Bacteria,4NPN9@976|Bacteroidetes,1FJI6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - NERD,Pkinase,TPR_12,TPR_8 CMS2_k127_168182_5 1382306.JNIM01000001_gene2755 1.858e-75 263.0 COG1335@1|root,COG1335@2|Bacteria,2G8KH@200795|Chloroflexi 200795|Chloroflexi Q isochorismatase - - - - - - - - - - - - - CMS2_k127_168182_1 401526.TcarDRAFT_2156 6.983e-118 395.0 COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,4H2WK@909932|Negativicutes 909932|Negativicutes H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP - - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - QRPTase_C,QRPTase_N CMS2_k127_168182_6 204669.Acid345_1150 4.362e-67 235.0 arCOG09454@1|root,31B41@2|Bacteria,3Y8HD@57723|Acidobacteria,2JNG1@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - CMS2_k127_168182_4 1220534.B655_1034 7.472e-77 278.0 COG1032@1|root,arCOG01356@2157|Archaea 2157|Archaea C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM CMS2_k127_168182_0 1381123.AYOD01000044_gene1739 6.525e-203 647.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,43J11@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 CMS2_k127_168182_8 1219065.VPR01S_01_03230 1.323e-41 159.0 28PFD@1|root,2ZC6I@2|Bacteria,1R8PT@1224|Proteobacteria,1S2BA@1236|Gammaproteobacteria,1XWFU@135623|Vibrionales 135623|Vibrionales - - VP2004 - - - - - - - - - - - - CMS2_k127_1719353_4 234267.Acid_1951 1.424e-150 493.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Sortilin-Vps10 CMS2_k127_1719353_7 1379270.AUXF01000002_gene1577 3.468e-122 422.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_1719353_3 1047013.AQSP01000112_gene371 8.87e-170 557.0 COG2091@1|root,COG2091@2|Bacteria,2NQ9X@2323|unclassified Bacteria 2|Bacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 CMS2_k127_1719353_5 588596.U9SKP0 3.805e-141 460.0 COG0334@1|root,KOG2250@2759|Eukaryota,39VR7@33154|Opisthokonta,3P7DY@4751|Fungi 4751|Fungi E Glu/Leu/Phe/Val dehydrogenase, dimerisation domain - - - - - - - - - - - - ELFV_dehydrog,ELFV_dehydrog_N CMS2_k127_1719353_1 861299.J421_2266 2.527e-223 707.0 COG3653@1|root,COG3653@2|Bacteria,1ZTDH@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 CMS2_k127_1719353_0 234267.Acid_7527 2.3e-295 930.0 COG3250@1|root,COG3250@2|Bacteria,3Y2PR@57723|Acidobacteria 57723|Acidobacteria G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.165 ko:K15855 ko00520,ko01100,map00520,map01100 - R01966 RC00049 ko00000,ko00001,ko01000 - - - Glyco_hydro_2 CMS2_k127_1719353_2 518766.Rmar_2278 1.751e-185 588.0 COG1593@1|root,COG1593@2|Bacteria,4NE5T@976|Bacteroidetes 976|Bacteroidetes G transporter, DctM subunit - - - - - - - - - - - - DctM CMS2_k127_1719353_10 518766.Rmar_2279 1.552e-46 173.0 COG3090@1|root,COG3090@2|Bacteria,4NNRW@976|Bacteroidetes 976|Bacteroidetes G TRAP-type C4-dicarboxylate transport system small permease component - - - - - - - - - - - - DctQ CMS2_k127_1719353_6 1124780.ANNU01000008_gene2696 3.738e-127 414.0 COG1638@1|root,COG1638@2|Bacteria,4NGV4@976|Bacteroidetes,47MM2@768503|Cytophagia 976|Bacteroidetes G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP CMS2_k127_1719353_9 1382304.JNIL01000001_gene1045 2.137e-57 215.0 COG3718@1|root,COG3718@2|Bacteria,1TR6M@1239|Firmicutes,4HCDY@91061|Bacilli 91061|Bacilli G Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D- gluconate) iolB - 5.3.1.30 ko:K03337 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08503 RC00541 ko00000,ko00001,ko01000 - - - KduI CMS2_k127_1719353_8 1382359.JIAL01000001_gene1348 9.687e-95 318.0 COG1028@1|root,COG1028@2|Bacteria,3Y3CD@57723|Acidobacteria,2JHIF@204432|Acidobacteriia 204432|Acidobacteriia IQ KR domain - - - - - - - - - - - - adh_short_C2 CMS2_k127_1719353_11 565655.ECBG_02099 1.094e-23 102.0 COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,4HAQZ@91061|Bacilli,4B1N9@81852|Enterococcaceae 91061|Bacilli G D-galactarate dehydratase / Altronate hydrolase, C terminus uxaA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0008789,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0071704,GO:0072329,GO:1901575 4.2.1.42,4.2.1.7 ko:K01685,ko:K01708 ko00040,ko00053,ko01100,map00040,map00053,map01100 M00631 R01540,R05608 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF CMS2_k127_1764233_3 1089550.ATTH01000001_gene2034 3.64e-43 159.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,1FJVI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran CMS2_k127_1764233_1 1089550.ATTH01000001_gene2033 1.1e-105 362.0 COG0845@1|root,COG0845@2|Bacteria,4PHXD@976|Bacteroidetes,1FKDG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 CMS2_k127_1764233_2 1089550.ATTH01000001_gene2031 3.336e-64 236.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP CMS2_k127_1764233_5 441769.ABFU01000037_gene241 1.4e-18 95.0 COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4HDQR@91061|Bacilli,1ZE5P@1386|Bacillus 91061|Bacilli I 1-acyl-sn-glycerol-3-phosphate acyltransferase plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase CMS2_k127_1764233_0 234267.Acid_1953 0.0 1324.0 COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria 57723|Acidobacteria S cellulose binding - - - - - - - - - - - - - CMS2_k127_1764233_4 879212.DespoDRAFT_00177 3.394e-21 100.0 COG0484@1|root,COG0484@2|Bacteria,1N19U@1224|Proteobacteria,42TX7@68525|delta/epsilon subdivisions,2WQMA@28221|Deltaproteobacteria,2MNA8@213118|Desulfobacterales 28221|Deltaproteobacteria O DnaJ molecular chaperone homology domain - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ CMS2_k127_1773631_6 1265505.ATUG01000001_gene3840 7.275e-129 419.0 COG0730@1|root,COG0730@2|Bacteria,1Q05R@1224|Proteobacteria,42NT9@68525|delta/epsilon subdivisions,2WJVB@28221|Deltaproteobacteria,2MJPE@213118|Desulfobacterales 28221|Deltaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE CMS2_k127_1773631_9 933262.AXAM01000007_gene2051 2.603e-42 163.0 COG2204@1|root,COG2204@2|Bacteria,1N33V@1224|Proteobacteria,42U3U@68525|delta/epsilon subdivisions,2WQ8H@28221|Deltaproteobacteria,2MK2M@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS2_k127_1773631_4 439235.Dalk_1275 2.169e-131 437.0 COG4191@1|root,COG4191@2|Bacteria,1P0U1@1224|Proteobacteria,42PTP@68525|delta/epsilon subdivisions,2WJ8U@28221|Deltaproteobacteria,2MIQ7@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA CMS2_k127_1773631_0 693661.Arcve_1697 1.972e-220 695.0 COG0247@1|root,arCOG00333@2157|Archaea 2157|Archaea C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K18501 - - - - ko00000 - - - CCG,Fer4_8 CMS2_k127_1773631_8 706587.Desti_0337 3.93e-55 204.0 COG2181@1|root,COG2181@2|Bacteria,1NFYW@1224|Proteobacteria,42VRY@68525|delta/epsilon subdivisions,2WRZ0@28221|Deltaproteobacteria,2MSFY@213462|Syntrophobacterales 28221|Deltaproteobacteria C Nitrate reductase gamma subunit - - - - - - - - - - - - Nitrate_red_gam CMS2_k127_1773631_13 1191523.MROS_1026 1.133e-28 121.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - ko:K13640 - - - - ko00000,ko03000 - - - MerR_1 CMS2_k127_1773631_12 706587.Desti_0283 3.359e-30 124.0 COG0745@1|root,COG0745@2|Bacteria,1NBQZ@1224|Proteobacteria,42V8P@68525|delta/epsilon subdivisions,2WS87@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg CMS2_k127_1773631_5 1121456.ATVA01000011_gene1345 7.68e-131 433.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2M8MZ@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,PAS_4,PAS_9,Response_reg CMS2_k127_1773631_14 575540.Isop_1453 5.873e-14 85.0 COG0745@1|root,COG0745@2|Bacteria,2IZRH@203682|Planctomycetes 203682|Planctomycetes T response regulator receiver - - - - - - - - - - - - Response_reg CMS2_k127_1773631_7 246194.CHY_2406 2.677e-117 400.0 COG0247@1|root,COG0247@2|Bacteria,1UZQ0@1239|Firmicutes,24E5H@186801|Clostridia,42F8Q@68295|Thermoanaerobacterales 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17 CMS2_k127_1773631_10 706587.Desti_0285 6.466e-35 147.0 COG2181@1|root,COG2181@2|Bacteria 2|Bacteria C nitrate reductase activity - - - - - - - - - - - - SLAC1 CMS2_k127_1773631_11 289376.THEYE_A0845 8.382e-31 128.0 COG2110@1|root,COG2110@2|Bacteria 2|Bacteria P phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - ko:K07478 - - - - ko00000 - - - Macro CMS2_k127_1773631_16 1538295.JY96_16490 6.539e-06 57.0 COG0745@1|root,COG0745@2|Bacteria,1QWG0@1224|Proteobacteria,2WGYI@28216|Betaproteobacteria,1KPDN@119065|unclassified Burkholderiales 28216|Betaproteobacteria KT Helix-turn-helix domain - - - - - - - - - - - - HTH_17,Response_reg CMS2_k127_1773631_2 880072.Desac_1620 6.646e-166 533.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MQYU@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 CMS2_k127_1773631_1 331678.Cphamn1_1855 1.662e-180 581.0 COG0493@1|root,COG0493@2|Bacteria,1FDFY@1090|Chlorobi 1090|Chlorobi C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2 CMS2_k127_1773631_3 1121428.DESHY_30086___1 1.769e-164 525.0 COG2221@1|root,COG2221@2|Bacteria,1TZD2@1239|Firmicutes,24DEF@186801|Clostridia,2610K@186807|Peptococcaceae 186801|Clostridia C TIGRFAM sulfite reductase, dissimilatory-type beta subunit dsrB - 1.8.99.5 ko:K11181 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - Fer4,NIR_SIR,NIR_SIR_ferr CMS2_k127_177683_5 1379270.AUXF01000007_gene994 1.736e-64 226.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_177683_2 1121957.ATVL01000008_gene4409 7.481e-279 879.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,47UBJ@768503|Cytophagia 976|Bacteroidetes G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C CMS2_k127_177683_3 518766.Rmar_1391 9.141e-107 357.0 COG0684@1|root,COG0684@2|Bacteria 2|Bacteria H ribonuclease inhibitor activity - - - - - - - - - - - - RraA-like CMS2_k127_177683_1 452637.Oter_2278 4.122e-306 977.0 COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,46Z55@74201|Verrucomicrobia,3K7F1@414999|Opitutae 414999|Opitutae G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 CMS2_k127_177683_9 1121468.AUBR01000007_gene272 2.755e-07 59.0 2AHG6@1|root,317TF@2|Bacteria,1W4C8@1239|Firmicutes,255NM@186801|Clostridia,42IXG@68295|Thermoanaerobacterales 186801|Clostridia - - - - - - - - - - - - - - - CMS2_k127_177683_0 537013.CLOSTMETH_03255 0.0 1436.0 COG1538@1|root,COG3408@1|root,COG1538@2|Bacteria,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,24AJX@186801|Clostridia,3WSSV@541000|Ruminococcaceae 186801|Clostridia GMU Psort location Extracellular, score - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,FIVAR CMS2_k127_177683_7 1121904.ARBP01000003_gene6312 5.288e-25 111.0 COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - HTH_18,TPR_8 CMS2_k127_177683_8 1183438.GKIL_0608 4.114e-08 58.0 2EGU9@1|root,33AKF@2|Bacteria,1GB1Q@1117|Cyanobacteria 1117|Cyanobacteria S Putative addiction module component - - - - - - - - - - - - Unstab_antitox CMS2_k127_177683_6 211165.AJLN01000104_gene6613 4.908e-25 107.0 COG3668@1|root,COG3668@2|Bacteria,1GKJ0@1117|Cyanobacteria,1JMAM@1189|Stigonemataceae 1117|Cyanobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin CMS2_k127_177683_4 1121904.ARBP01000003_gene6312 2.75e-69 255.0 COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - HTH_18,TPR_8 CMS2_k127_180086_6 861299.J421_1545 9.435e-55 219.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS2_k127_180086_1 1254432.SCE1572_50310 1.264e-171 567.0 COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,438BA@68525|delta/epsilon subdivisions,2X3KK@28221|Deltaproteobacteria,2YWFN@29|Myxococcales 28221|Deltaproteobacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_180086_4 477974.Daud_0521 6.729e-64 230.0 COG0667@1|root,COG0667@2|Bacteria,1UHXA@1239|Firmicutes,25E68@186801|Clostridia,267DB@186807|Peptococcaceae 186801|Clostridia C Aldo/keto reductase family - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red CMS2_k127_180086_5 886379.AEWI01000075_gene1958 3.376e-55 198.0 COG1917@1|root,COG1917@2|Bacteria,4NR0K@976|Bacteroidetes,2FXRD@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 CMS2_k127_180086_3 1121129.KB903359_gene2127 2.88e-103 349.0 COG0599@1|root,COG1917@1|root,COG0599@2|Bacteria,COG1917@2|Bacteria,4NFEI@976|Bacteroidetes,2FSAB@200643|Bacteroidia,22XTZ@171551|Porphyromonadaceae 976|Bacteroidetes S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD,Cupin_2 CMS2_k127_180086_2 935565.JAEM01000022_gene3573 2.187e-122 404.0 COG0657@1|root,COG0657@2|Bacteria,1R41U@1224|Proteobacteria,2U17T@28211|Alphaproteobacteria,2PYGA@265|Paracoccus 28211|Alphaproteobacteria I Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 CMS2_k127_180086_0 760192.Halhy_0712 4.611e-259 808.0 COG2272@1|root,COG2272@2|Bacteria,4NF5N@976|Bacteroidetes,1IQ9M@117747|Sphingobacteriia 976|Bacteroidetes I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase CMS2_k127_1818187_0 945713.IALB_2155 6.791e-138 454.0 COG2195@1|root,COG2195@2|Bacteria 2|Bacteria E Cleaves the N-terminal amino acid of tripeptides pepD GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - iPC815.YPO3230,iSBO_1134.SBO_0243 M20_dimer,Peptidase_M20 CMS2_k127_1818187_1 861299.J421_2450 8.617e-120 394.0 COG1363@1|root,COG1363@2|Bacteria,1ZTF5@142182|Gemmatimonadetes 142182|Gemmatimonadetes G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 CMS2_k127_1818187_2 861299.J421_2448 1.759e-86 301.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,1ZTZW@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS2_k127_1818187_4 1379270.AUXF01000004_gene3357 1.067e-55 205.0 COG0596@1|root,COG0596@2|Bacteria,1ZTAV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Serine aminopeptidase, S33 - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_6 CMS2_k127_1818187_3 266117.Rxyl_2676 2.11e-80 273.0 COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4CTQB@84995|Rubrobacteria 84995|Rubrobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD CMS2_k127_1818187_6 1379270.AUXF01000004_gene3272 9.312e-18 90.0 2A0X4@1|root,30P27@2|Bacteria,1ZUWS@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1818187_5 1120999.JONM01000005_gene3786 1.045e-44 181.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,2KRIN@206351|Neisseriales 206351|Neisseriales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT,PMT_2 CMS2_k127_1837955_0 1048983.EL17_12315 2.525e-194 616.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF CMS2_k127_1837955_3 1379270.AUXF01000005_gene643 5.671e-126 428.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZTF0@142182|Gemmatimonadetes 142182|Gemmatimonadetes EU Acetyl xylan esterase (AXE1) - - - - - - - - - - - - PD40,Peptidase_S9 CMS2_k127_1837955_6 1348114.OM33_20420 1.198e-19 92.0 COG1695@1|root,COG1695@2|Bacteria,1N4DF@1224|Proteobacteria,1SBH1@1236|Gammaproteobacteria,2Q31Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K transcriptional regulators - - - - - - - - - - - - PadR CMS2_k127_1837955_1 251221.35211765 5.75e-153 516.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_1837955_4 880073.Calab_2536 1.093e-89 303.0 COG1045@1|root,COG1045@2|Bacteria,2NPQG@2323|unclassified Bacteria 2|Bacteria E Bacterial transferase hexapeptide (six repeats) cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N CMS2_k127_1837955_2 1278073.MYSTI_01696 3.232e-136 441.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YWJD@29|Myxococcales 28221|Deltaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_1837955_5 1279017.AQYJ01000028_gene2525 6.595e-78 271.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,46479@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B CMS2_k127_1851426_13 1345695.CLSA_c37100 4.176e-39 156.0 COG0641@1|root,COG0641@2|Bacteria,1TT6S@1239|Firmicutes,248QW@186801|Clostridia,36FP9@31979|Clostridiaceae 186801|Clostridia C Radical SAM ccpM - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM CMS2_k127_1851426_0 314285.KT71_13030 8.574e-200 634.0 COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,1RY1C@1236|Gammaproteobacteria,1J7RH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_1851426_3 861299.J421_3530 4.735e-145 494.0 COG1629@1|root,COG4771@2|Bacteria,1ZST4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P CarboxypepD_reg-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_1851426_8 1313421.JHBV01000007_gene4195 4.083e-89 317.0 COG2866@1|root,COG2866@2|Bacteria,4NF5T@976|Bacteroidetes,1IQ41@117747|Sphingobacteriia 976|Bacteroidetes E Peptidase M14, carboxypeptidase A - - - - - - - - - - - - Peptidase_M14 CMS2_k127_1851426_2 861299.J421_0410 5.327e-174 579.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1851426_15 1117318.PRUB_08200 1.428e-20 95.0 COG1695@1|root,COG1695@2|Bacteria,1N4DF@1224|Proteobacteria,1SBH1@1236|Gammaproteobacteria,2Q31Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K transcriptional regulators - - - - - - - - - - - - PadR CMS2_k127_1851426_9 861299.J421_4135 1.266e-86 321.0 COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_1851426_4 251221.35212957 2.839e-108 387.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - CsgG,TPR_16 CMS2_k127_1851426_1 234267.Acid_3043 1.885e-192 617.0 COG3055@1|root,COG3055@2|Bacteria,3Y6HA@57723|Acidobacteria 2|Bacteria M Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - Collagen_bind_2,DUF5060,Kelch_1,Kelch_6,Malectin,NPCBM CMS2_k127_1851426_11 485913.Krac_10800 2.13e-77 286.0 COG2866@1|root,COG2866@2|Bacteria,2G7PS@200795|Chloroflexi 200795|Chloroflexi E PFAM peptidase M14 carboxypeptidase A - - - - - - - - - - - - Peptidase_M14 CMS2_k127_1851426_16 1124780.ANNU01000019_gene1696 1.217e-06 61.0 2DS15@1|root,33E22@2|Bacteria,4NYSK@976|Bacteroidetes,47WV4@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_1851426_14 632292.Calhy_0272 1.324e-26 123.0 COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales 186801|Clostridia H PFAM Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D CMS2_k127_1851426_6 237368.SCABRO_00906 4.698e-95 334.0 COG0612@1|root,COG0612@2|Bacteria,2IYKK@203682|Planctomycetes 203682|Planctomycetes S PFAM Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_1851426_10 1379698.RBG1_1C00001G0711 1.739e-85 305.0 COG0612@1|root,COG0612@2|Bacteria,2NQHV@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) ymxG - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_1851426_7 1415780.JPOG01000001_gene2063 1.575e-90 307.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1X3I1@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 CMS2_k127_1851426_5 234267.Acid_6585 4.714e-102 351.0 COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria 57723|Acidobacteria E Peptidase M14, carboxypeptidase A - - - - - - - - - - - - Peptidase_M14 CMS2_k127_1875753_2 215803.DB30_4178 2.847e-05 56.0 COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales 28221|Deltaproteobacteria O Fibronectin type 3 domain - - - - - - - - - - - - Peptidase_M6,Peptidase_S8 CMS2_k127_1875753_0 357808.RoseRS_1915 5.563e-23 112.0 COG0823@1|root,COG0823@2|Bacteria,2G8PZ@200795|Chloroflexi,377MH@32061|Chloroflexia 32061|Chloroflexia U WD40 domain protein beta Propeller - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS2_k127_1875753_3 926566.Terro_3036 0.0003987 44.0 2EEHM@1|root,338BG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_1875753_1 373994.Riv7116_1673 5.126e-06 59.0 COG3209@1|root,COG3209@2|Bacteria,1GQ0G@1117|Cyanobacteria,1HN8U@1161|Nostocales 1117|Cyanobacteria MU Dystroglycan-type cadherin-like domains. - - - - - - - - - - - - Cadherin,He_PIG,RHS_repeat CMS2_k127_1879483_5 1123386.AUIW01000009_gene1813 4.449e-06 53.0 2DGZ3@1|root,2ZXUD@2|Bacteria,1WKRC@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Antitoxin Phd_YefM, type II toxin-antitoxin system - - - - - - - - - - - - PhdYeFM_antitox CMS2_k127_1879483_0 880073.Calab_2995 8.752e-184 588.0 COG0606@1|root,COG0606@2|Bacteria,2NNW7@2323|unclassified Bacteria 2|Bacteria O Magnesium chelatase, subunit ChlI C-terminal comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C CMS2_k127_1879483_4 1121936.AUHI01000008_gene436 1.63e-34 143.0 COG2102@1|root,COG2102@2|Bacteria,1UAKZ@1239|Firmicutes,4HDX8@91061|Bacilli 91061|Bacilli S ATPases of PP-loop superfamily - - - - - - - - - - - - Diphthami_syn_2 CMS2_k127_1879483_2 661478.OP10G_0240 3.118e-97 348.0 COG1626@1|root,COG1626@2|Bacteria 2|Bacteria G alpha,alpha-trehalase activity ygjK GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716 3.2.1.28 ko:K01194,ko:K03931 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37,GH63 - Glyco_hydro_63,Trehalase CMS2_k127_1879483_1 502025.Hoch_4836 9.41e-118 392.0 COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria 1224|Proteobacteria P Major facilitator Superfamily - - - - - - - - - - - - MFS_1 CMS2_k127_1879483_3 404589.Anae109_3427 2.697e-36 140.0 COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria,2YUW8@29|Myxococcales 28221|Deltaproteobacteria F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C CMS2_k127_1900433_6 383372.Rcas_0705 4.411e-29 118.0 COG2250@1|root,COG2250@2|Bacteria 2|Bacteria S HEPN domain - - - - - - - - - - - - HEPN CMS2_k127_1900433_10 324602.Caur_3225 7.603e-09 59.0 COG1669@1|root,COG1669@2|Bacteria,2G9Y2@200795|Chloroflexi,377UA@32061|Chloroflexia 32061|Chloroflexia L Nucleotidyltransferase domain - - - - - - - - - - - - NTP_transf_2 CMS2_k127_1900433_2 1273538.G159_02725 1.063e-69 251.0 COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HA0E@91061|Bacilli,26EHT@186818|Planococcaceae 91061|Bacilli E Saccharopine dehydrogenase C-terminal domain - - 1.4.1.18 ko:K19064 ko00960,ko01100,ko01110,map00960,map01100,map01110 - R00446,R02317 RC00062,RC00694 ko00000,ko00001,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP CMS2_k127_1900433_0 861299.J421_1048 8.957e-244 781.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_1900433_4 297246.plpp0079 6.051e-35 145.0 COG2819@1|root,COG2819@2|Bacteria,1RB1X@1224|Proteobacteria,1S6C2@1236|Gammaproteobacteria,1JDRS@118969|Legionellales 118969|Legionellales S Putative esterase besA - - ko:K07017 - - - - ko00000 - - - Esterase CMS2_k127_1900433_3 1379270.AUXF01000002_gene1345 8.362e-62 244.0 COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_1900433_1 1183438.GKIL_4354 3.344e-160 549.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1900433_9 1211115.ALIQ01000124_gene4254 5.219e-15 82.0 COG4978@1|root,COG4978@2|Bacteria,1R4X9@1224|Proteobacteria,2TUZK@28211|Alphaproteobacteria,3NAZE@45404|Beijerinckiaceae 28211|Alphaproteobacteria KT Bacterial transcription activator, effector binding domain MA20_43725 - - - - - - - - - - - GyrI-like CMS2_k127_1900433_5 1185876.BN8_01704 2.161e-30 133.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,47KK7@768503|Cytophagia 976|Bacteroidetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 CMS2_k127_1900433_8 861299.J421_2665 1.162e-16 92.0 COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG1629@2|Bacteria,1ZTMF@142182|Gemmatimonadetes 142182|Gemmatimonadetes MP Gram-negative bacterial TonB protein C-terminal - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_C CMS2_k127_1900433_11 1201288.M900_0273 3.87e-07 59.0 COG2010@1|root,COG2010@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2MUN1@213481|Bdellovibrionales,2WPS4@28221|Deltaproteobacteria 213481|Bdellovibrionales C Cytochrome c pcmF - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 CMS2_k127_1930100_6 861299.J421_1230 0.0002799 46.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_1930100_3 309798.COPRO5265_0451 2.314e-57 216.0 COG0308@1|root,COG0308@2|Bacteria,1VMQ2@1239|Firmicutes 1239|Firmicutes E aminopeptidase N - - - - - - - - - - - - Peptidase_M1 CMS2_k127_1930100_2 1379270.AUXF01000002_gene1599 1.223e-97 350.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1599|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_1930100_1 742738.HMPREF9460_00425 4.261e-124 417.0 COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,268Q9@186813|unclassified Clostridiales 186801|Clostridia S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 CMS2_k127_1930100_0 1267535.KB906767_gene3834 5.118e-141 484.0 COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria 57723|Acidobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1930100_4 234267.Acid_5962 1.141e-35 138.0 COG1695@1|root,COG1695@2|Bacteria,3Y873@57723|Acidobacteria 57723|Acidobacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_1930100_5 644107.SL1157_0963 1.403e-07 58.0 COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria,2UFEE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC CMS2_k127_1931010_9 1278073.MYSTI_04090 8.85e-49 190.0 COG3568@1|root,COG3568@2|Bacteria,1N29G@1224|Proteobacteria,438Z7@68525|delta/epsilon subdivisions,2X8PT@28221|Deltaproteobacteria,2YY8K@29|Myxococcales 28221|Deltaproteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos CMS2_k127_1931010_6 1047013.AQSP01000140_gene2513 7.329e-63 229.0 COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria 2|Bacteria S RmuC family rmuC - - ko:K09760 - - - - ko00000 - - - RmuC CMS2_k127_1931010_10 1121479.AUBS01000005_gene2667 7.361e-27 119.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria 28211|Alphaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase CMS2_k127_1931010_11 1379270.AUXF01000001_gene2022 1.446e-17 83.0 COG4877@1|root,COG4877@2|Bacteria,1ZVAE@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_1931010_4 913325.N799_14350 7.942e-102 340.0 COG0330@1|root,COG0330@2|Bacteria,1P8ZI@1224|Proteobacteria,1RUQU@1236|Gammaproteobacteria,1X4NG@135614|Xanthomonadales 135614|Xanthomonadales O membrane - - - - - - - - - - - - Band_7 CMS2_k127_1931010_0 379066.GAU_3171 3.509e-192 628.0 COG5549@1|root,COG5549@2|Bacteria 2|Bacteria O protein import - - - - - - - - - - - - CBM60,DUF4953,DUF5117,DUF5118 CMS2_k127_1931010_2 243233.MCA0142 4.409e-123 407.0 COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,1S1GI@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Sodium/calcium exchanger protein - - - ko:K07300 - - - - ko00000,ko02000 2.A.19 - - Na_Ca_ex CMS2_k127_1931010_3 518766.Rmar_1357 4.988e-114 381.0 COG1680@1|root,COG1680@2|Bacteria,4NJ0F@976|Bacteroidetes 976|Bacteroidetes V Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase CMS2_k127_1931010_1 880073.Calab_1134 1.877e-170 569.0 COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_1931010_8 502558.EGYY_06890 1.463e-51 190.0 COG0546@1|root,COG0546@2|Bacteria,2I9FC@201174|Actinobacteria,4CVWZ@84998|Coriobacteriia 84998|Coriobacteriia S IA, variant 3 - - 3.6.1.1 ko:K06019 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - HAD_2 CMS2_k127_1931010_5 861299.J421_4487 1.697e-88 306.0 COG3595@1|root,COG3595@2|Bacteria,1ZTJA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative adhesin - - - - - - - - - - - - DUF4097 CMS2_k127_1931010_13 314231.FP2506_08381 1.032e-06 53.0 COG2020@1|root,COG2020@2|Bacteria,1PDMB@1224|Proteobacteria,2VAAR@28211|Alphaproteobacteria,2PK7W@255475|Aurantimonadaceae 28211|Alphaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT CMS2_k127_1931010_12 379066.GAU_0799 1.011e-06 61.0 COG4932@1|root,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - DUF11,DUF5011,Gram_pos_anchor,SdrD_B CMS2_k127_1931010_15 379066.GAU_1201 0.0008284 51.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - Bac_surface_Ag,PD40 CMS2_k127_1931010_7 452637.Oter_4300 1.527e-58 207.0 COG3189@1|root,COG3189@2|Bacteria,46WUI@74201|Verrucomicrobia,3K8H8@414999|Opitutae 414999|Opitutae S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 CMS2_k127_1931010_14 306281.AJLK01000101_gene3315 1.777e-06 55.0 2E1PV@1|root,32X09@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_1933791_5 572477.Alvin_1035 4.777e-18 85.0 COG1280@1|root,COG1280@2|Bacteria,1RF18@1224|Proteobacteria,1S4TM@1236|Gammaproteobacteria,1WYI1@135613|Chromatiales 135613|Chromatiales E PFAM Lysine exporter protein (LYSE YGGA) - - - - - - - - - - - - LysE CMS2_k127_1933791_3 1279009.ADICEAN_01016 4.014e-28 119.0 COG4319@1|root,COG4319@2|Bacteria,4NTMK@976|Bacteroidetes,47X83@768503|Cytophagia 976|Bacteroidetes S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS2_k127_1933791_0 379066.GAU_2695 3.457e-111 369.0 COG1234@1|root,COG1234@2|Bacteria,1ZTG7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 CMS2_k127_1933791_4 1122621.ATZA01000033_gene507 6.937e-19 97.0 COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,1IQZY@117747|Sphingobacteriia 976|Bacteroidetes Q ABC-type transport system involved in resistance to organic solvents periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS2_k127_1933791_1 1379270.AUXF01000004_gene3177 1.844e-71 252.0 COG1127@1|root,COG1127@2|Bacteria,1ZT5N@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran CMS2_k127_1933791_2 1379270.AUXF01000001_gene2818 1.86e-52 195.0 COG0767@1|root,COG0767@2|Bacteria,1ZSUC@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS2_k127_1941187_4 234267.Acid_7851 1.177e-79 286.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria 57723|Acidobacteria K Tetratricopeptide repeat - - - - - - - - - - - - - CMS2_k127_1941187_6 861299.J421_4220 1.442e-56 209.0 COG2367@1|root,COG2367@2|Bacteria,1ZT83@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Beta-lactamase enzyme family - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 CMS2_k127_1941187_2 237368.SCABRO_02564 6.31e-103 355.0 COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2IZEZ@203682|Planctomycetes 203682|Planctomycetes S Memo-like protein - - - - - - - - - - - - AMMECR1,Memo CMS2_k127_1941187_5 1499967.BAYZ01000068_gene1969 1.157e-71 255.0 COG2006@1|root,COG2006@2|Bacteria,2NPI6@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 CMS2_k127_1941187_1 237368.SCABRO_03950 2.217e-138 451.0 COG1180@1|root,COG1180@2|Bacteria,2IYWA@203682|Planctomycetes 203682|Planctomycetes C Radical SAM superfamily - - - - - - - - - - - - Fer4_12,Radical_SAM CMS2_k127_1941187_3 237368.SCABRO_03955 1.284e-87 320.0 COG4262@1|root,COG4262@2|Bacteria 2|Bacteria H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth CMS2_k127_1941187_0 861299.J421_5840 1.955e-226 735.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_1953352_2 215803.DB30_4063 1.353e-198 628.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,42PGV@68525|delta/epsilon subdivisions,2WIS0@28221|Deltaproteobacteria,2YZVC@29|Myxococcales 28221|Deltaproteobacteria Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 CMS2_k127_1953352_26 572479.Hprae_1769 5.292e-18 86.0 COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,3WC2B@53433|Halanaerobiales 186801|Clostridia CO TIGRFAM small redox-active disulfide protein 2 - - - - - - - - - - - - Thioredoxin_3 CMS2_k127_1953352_4 338963.Pcar_0184 6.768e-178 567.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,43TRX@69541|Desulfuromonadales 28221|Deltaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 CMS2_k127_1953352_17 641491.DND132_2311 3.669e-34 133.0 COG0640@1|root,COG0640@2|Bacteria,1N19R@1224|Proteobacteria,42TRS@68525|delta/epsilon subdivisions,2WQHU@28221|Deltaproteobacteria,2MC8X@213115|Desulfovibrionales 28221|Deltaproteobacteria K SMART regulatory protein ArsR - - - - - - - - - - - - HTH_20,HTH_5 CMS2_k127_1953352_13 330214.NIDE3508 3.156e-64 229.0 28N6F@1|root,2ZBBB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_1953352_30 880071.Fleli_0018 1.595e-08 64.0 COG2067@1|root,COG2067@2|Bacteria,4NVVD@976|Bacteroidetes 976|Bacteroidetes I long-chain fatty acid transport protein - - - - - - - - - - - - OMP_b-brl CMS2_k127_1953352_14 1499967.BAYZ01000033_gene1106 2.645e-61 218.0 COG3382@1|root,COG3382@2|Bacteria 2|Bacteria J B3 4 domain protein - - - - - - - - - - - - B3_4 CMS2_k127_1953352_21 1347392.CCEZ01000015_gene2772 1.77e-23 104.0 COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,36FKV@31979|Clostridiaceae 186801|Clostridia S flavin reductase - - - - - - - - - - - - Flavin_Reduct CMS2_k127_1953352_1 1122931.AUAE01000007_gene1342 3.75e-264 852.0 COG0457@1|root,COG0457@2|Bacteria,4NKMF@976|Bacteroidetes,2FXC5@200643|Bacteroidia,231HD@171551|Porphyromonadaceae 1122931.AUAE01000007_gene1342|- S Domain of unknown function (DUF5107) - - - - - - - - - - - - - CMS2_k127_1953352_15 404589.Anae109_2816 1.069e-47 182.0 COG0697@1|root,COG0697@2|Bacteria,1R03B@1224|Proteobacteria,42S5I@68525|delta/epsilon subdivisions,2WNXS@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS2_k127_1953352_23 1121481.AUAS01000008_gene2900 1.093e-21 98.0 COG1695@1|root,COG1695@2|Bacteria,4NQJP@976|Bacteroidetes,47QWB@768503|Cytophagia 976|Bacteroidetes K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_1953352_10 861299.J421_5960 7.477e-110 389.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_1953352_27 103733.JNYO01000042_gene6062 5.761e-18 87.0 COG1695@1|root,COG1695@2|Bacteria,2GUXT@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_1953352_3 251221.35211765 1.84e-181 602.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_1953352_0 861299.J421_0588 1.695e-301 957.0 COG4447@1|root,COG4447@2|Bacteria,1ZSRH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 CMS2_k127_1953352_29 1410653.JHVC01000029_gene1169 7.725e-11 64.0 COG4689@1|root,COG4689@2|Bacteria,1V2U5@1239|Firmicutes,24CZF@186801|Clostridia,36H3R@31979|Clostridiaceae 186801|Clostridia Q Catalyzes the conversion of acetoacetate to acetone and carbon dioxide adc - 4.1.1.4 ko:K01574 ko00072,ko00640,ko01100,map00072,map00640,map01100 M00088 R01366 RC00040 ko00000,ko00001,ko00002,ko01000 - - - ADC CMS2_k127_1953352_25 1121920.AUAU01000004_gene669 1.556e-19 98.0 2D0AC@1|root,32T87@2|Bacteria,3Y56N@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - CMS2_k127_1953352_8 861299.J421_5836 6.752e-147 498.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_1953352_12 861299.J421_0887 3.566e-100 359.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_1953352_6 1379270.AUXF01000002_gene1577 1.18e-174 574.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_1953352_28 479432.Sros_1231 5.772e-18 95.0 COG2321@1|root,COG2321@2|Bacteria,2HBKZ@201174|Actinobacteria,4EIKB@85012|Streptosporangiales 201174|Actinobacteria S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase CMS2_k127_1953352_20 1248760.ANFZ01000018_gene758 2.443e-26 117.0 COG0500@1|root,COG2226@2|Bacteria,1PVPS@1224|Proteobacteria,2TREE@28211|Alphaproteobacteria,2JZZE@204457|Sphingomonadales 204457|Sphingomonadales Q ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 CMS2_k127_1953352_24 670487.Ocepr_0558 5.191e-20 101.0 COG0607@1|root,COG0607@2|Bacteria 2|Bacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - Rhodanese CMS2_k127_1953352_16 1408473.JHXO01000001_gene1976 3.081e-43 170.0 COG0666@1|root,COG1835@1|root,COG0666@2|Bacteria,COG1835@2|Bacteria,4NIVR@976|Bacteroidetes,2FN9F@200643|Bacteroidia 976|Bacteroidetes I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 CMS2_k127_1953352_19 1293054.HSACCH_00888 5.312e-31 136.0 COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF362 CMS2_k127_1953352_22 1122137.AQXF01000002_gene370 3.367e-22 106.0 2DZI5@1|root,32VBA@2|Bacteria,1NZ5C@1224|Proteobacteria,2UUEW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ABC-2 family transporter protein - - - - - - - - - - - - - CMS2_k127_1953352_11 1122137.AQXF01000002_gene371 4.329e-106 351.0 COG1131@1|root,COG1131@2|Bacteria,1R9P3@1224|Proteobacteria,2UNTJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - ABC_tran CMS2_k127_1953352_18 1282361.ABAC402_08240 3.319e-33 132.0 COG1725@1|root,COG1725@2|Bacteria,1NBUH@1224|Proteobacteria,2UM7T@28211|Alphaproteobacteria 28211|Alphaproteobacteria K helix_turn_helix gluconate operon transcriptional repressor - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR CMS2_k127_1953352_7 1499967.BAYZ01000154_gene1524 2.135e-164 524.0 COG2230@1|root,COG2230@2|Bacteria,2NQ94@2323|unclassified Bacteria 2|Bacteria M Mycolic acid cyclopropane synthetase cfa - 2.1.1.317,2.1.1.79 ko:K00574,ko:K20238 - - - - ko00000,ko01000 - - - CMAS CMS2_k127_1953352_9 452637.Oter_3546 3.468e-127 421.0 COG1914@1|root,COG1914@2|Bacteria 2|Bacteria P metal ion transmembrane transporter activity - - - - - - - - - - - - Nramp CMS2_k127_1953352_5 452637.Oter_3714 2.667e-176 567.0 COG4124@1|root,COG4124@2|Bacteria,46TGN@74201|Verrucomicrobia 74201|Verrucomicrobia G Glycosyl hydrolase family 26 - - - - - - - - - - - - Glyco_hydro_26 CMS2_k127_2033969_9 861299.J421_1911 1.699e-28 116.0 COG1278@1|root,COG1278@2|Bacteria 2|Bacteria K Cold shock - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS2_k127_2033969_8 861299.J421_3696 8.165e-30 119.0 COG0361@1|root,COG0361@2|Bacteria,1ZV5Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex - - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a CMS2_k127_2033969_1 1519464.HY22_06470 5.523e-162 522.0 COG1473@1|root,COG1473@2|Bacteria,1FDR4@1090|Chlorobi 2|Bacteria S peptidase dimerisation domain protein - - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 CMS2_k127_2033969_5 861299.J421_4103 6.906e-71 264.0 COG0515@1|root,COG5184@1|root,COG0515@2|Bacteria,COG5184@2|Bacteria,1ZUHN@142182|Gemmatimonadetes 142182|Gemmatimonadetes DKLTZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - Pkinase,RCC1 CMS2_k127_2033969_10 671143.DAMO_1125 1.261e-15 79.0 COG0640@1|root,COG0640@2|Bacteria,2NQ4D@2323|unclassified Bacteria 2|Bacteria K helix_turn_helix, Arsenical Resistance Operon Repressor arsR - - ko:K03892,ko:K21903 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 CMS2_k127_2033969_11 91464.S7335_997 4.058e-07 55.0 29BRG@1|root,2ZYPV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_2033969_6 91464.S7335_997 5.506e-52 192.0 29BRG@1|root,2ZYPV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_2033969_12 195253.Syn6312_1372 0.0001872 48.0 2DEPP@1|root,32U3T@2|Bacteria,1G8TR@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS2_k127_2033969_2 1379698.RBG1_1C00001G0813 7.954e-99 341.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red CMS2_k127_2033969_7 1121904.ARBP01000002_gene7201 2.597e-45 172.0 COG2062@1|root,COG2062@2|Bacteria,4NQFM@976|Bacteroidetes,47R7I@768503|Cytophagia 976|Bacteroidetes T PFAM Phosphoglycerate mutase sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 CMS2_k127_2033969_3 1210884.HG799470_gene14473 7.186e-84 292.0 COG4447@1|root,COG4447@2|Bacteria,2J0B6@203682|Planctomycetes 203682|Planctomycetes S cellulose binding - - - - - - - - - - - - PSII_BNR CMS2_k127_2033969_0 1340493.JNIF01000004_gene1066 9.14e-187 599.0 COG1473@1|root,COG1473@2|Bacteria 2|Bacteria S N-acetyldiaminopimelate deacetylase activity - - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 CMS2_k127_2033969_4 679201.HMPREF9334_01103 2.174e-75 263.0 COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4H3FG@909932|Negativicutes 909932|Negativicutes S TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DUF3394,DctM CMS2_k127_2049706_35 1379270.AUXF01000006_gene260 1.817e-23 106.0 COG0586@1|root,COG0586@2|Bacteria,1ZTVI@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc CMS2_k127_2049706_27 518766.Rmar_1099 3.909e-46 172.0 COG0245@1|root,COG0245@2|Bacteria,4NP0N@976|Bacteroidetes,1FJAC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB CMS2_k127_2049706_10 1125863.JAFN01000001_gene886 1.799e-139 454.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42N1P@68525|delta/epsilon subdivisions,2WM2V@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM aminotransferase class I and II - - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_2049706_31 1171373.PACID_24130 1.818e-35 140.0 COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4DQ6R@85009|Propionibacteriales 201174|Actinobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE GO:0008150,GO:0040007 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3275c AIRC CMS2_k127_2049706_7 867903.ThesuDRAFT_00304 9.836e-160 512.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WCS5@538999|Clostridiales incertae sedis 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt CMS2_k127_2049706_33 861299.J421_3269 3.151e-28 115.0 COG0236@1|root,COG0236@2|Bacteria,1ZU0X@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding CMS2_k127_2049706_19 861299.J421_3270 2.03e-83 284.0 COG1028@1|root,COG1028@2|Bacteria,1ZT4H@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS2_k127_2049706_18 861299.J421_3271 7.891e-85 294.0 COG0331@1|root,COG0331@2|Bacteria,1ZT40@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Acyl transferase domain - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 CMS2_k127_2049706_14 379066.GAU_1639 6.809e-117 387.0 COG0332@1|root,COG0332@2|Bacteria,1ZSP4@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C CMS2_k127_2049706_16 861299.J421_3273 4.925e-101 340.0 COG0416@1|root,COG0416@2|Bacteria,1ZSN4@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis CMS2_k127_2049706_36 1379270.AUXF01000006_gene249 1.024e-17 83.0 COG0333@1|root,COG0333@2|Bacteria,1ZU2M@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal L32p protein family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p CMS2_k127_2049706_30 861299.J421_3275 2.903e-36 143.0 COG1399@1|root,COG1399@2|Bacteria,1ZTSW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Uncharacterized ACR, COG1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 CMS2_k127_2049706_26 379066.GAU_1643 2.412e-47 173.0 COG0105@1|root,COG0105@2|Bacteria,1ZTTD@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NDK - - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK CMS2_k127_2049706_24 861299.J421_3277 3.246e-61 222.0 COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria,1ZUGZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes GT Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - - - - - - - - - - CBS,PTS_EIIA_2 CMS2_k127_2049706_11 1379270.AUXF01000006_gene246 4.016e-136 438.0 COG0074@1|root,COG0074@2|Bacteria,1ZT20@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA CMS2_k127_2049706_6 861299.J421_3279 1.429e-161 516.0 COG0045@1|root,COG0045@2|Bacteria,1ZSZ4@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA CMS2_k127_2049706_21 877455.Metbo_1053 6.341e-78 271.0 COG0549@1|root,arCOG00863@2157|Archaea,2XTCB@28890|Euryarchaeota 28890|Euryarchaeota E Belongs to the carbamate kinase family cpkA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase CMS2_k127_2049706_8 861299.J421_3281 1.494e-150 489.0 COG1109@1|root,COG1109@2|Bacteria,1ZSP6@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS2_k127_2049706_13 861299.J421_3282 4.431e-120 402.0 COG1007@1|root,COG1007@2|Bacteria,1ZSVJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M CMS2_k127_2049706_5 880072.Desac_2105 4.632e-172 554.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MRBS@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M CMS2_k127_2049706_1 861299.J421_3284 9.66e-215 685.0 COG1009@1|root,COG1009@2|Bacteria,1ZSZY@142182|Gemmatimonadetes 142182|Gemmatimonadetes CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N CMS2_k127_2049706_34 1519464.HY22_11610 2.11e-26 112.0 COG0713@1|root,COG0713@2|Bacteria,1FFEB@1090|Chlorobi 1090|Chlorobi C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 CMS2_k127_2049706_32 861299.J421_3286 5.189e-34 136.0 COG0839@1|root,COG0839@2|Bacteria,1ZTSA@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 CMS2_k127_2049706_20 1379270.AUXF01000006_gene237 2.747e-79 273.0 COG1143@1|root,COG1143@2|Bacteria,1ZTHB@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4_7 CMS2_k127_2049706_12 861299.J421_3288 7.931e-129 423.0 COG1005@1|root,COG1005@2|Bacteria,1ZTDY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh CMS2_k127_2049706_4 861299.J421_3289 2.81e-181 584.0 COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria,1ZTDW@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3 CMS2_k127_2049706_2 379066.GAU_1657 5.216e-204 645.0 COG1894@1|root,COG1894@2|Bacteria,1ZSQD@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB CMS2_k127_2049706_22 1379270.AUXF01000006_gene233 1.313e-73 251.0 COG1905@1|root,COG1905@2|Bacteria,1ZTJ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx CMS2_k127_2049706_3 861299.J421_3292 8.773e-201 632.0 COG0649@1|root,COG0649@2|Bacteria,1ZSV6@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa CMS2_k127_2049706_23 379066.GAU_1660 1.535e-71 248.0 COG0852@1|root,COG0852@2|Bacteria,1ZTCJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa CMS2_k127_2049706_17 861299.J421_3294 5.545e-94 315.0 COG0377@1|root,COG0377@2|Bacteria,1ZT85@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 CMS2_k127_2049706_28 1379270.AUXF01000006_gene229 1.812e-40 153.0 COG0838@1|root,COG0838@2|Bacteria,1ZTKK@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 CMS2_k127_2049706_29 882378.RBRH_03123 1.3e-39 151.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria,1K38F@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase CMS2_k127_2049706_0 558169.AGAV01000018_gene3490 3.163e-215 682.0 COG1228@1|root,COG1228@2|Bacteria,1W6UE@1239|Firmicutes,4HAQJ@91061|Bacilli 91061|Bacilli Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS2_k127_2049706_15 379066.GAU_2023 1.637e-116 388.0 COG1473@1|root,COG1473@2|Bacteria,1ZUHE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS2_k127_2049706_9 189753.AXAS01000014_gene5514 2.792e-146 478.0 COG4626@1|root,COG4626@2|Bacteria,1MW9D@1224|Proteobacteria,2TVMI@28211|Alphaproteobacteria,3JX3N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Terminase - - - - - - - - - - - - - CMS2_k127_2049706_25 856793.MICA_562 2.981e-48 191.0 28IAN@1|root,2Z8D8@2|Bacteria,1NJD6@1224|Proteobacteria,2U7YP@28211|Alphaproteobacteria,4BR2J@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4055) - - - - - - - - - - - - DUF4055 CMS2_k127_205111_14 861299.J421_2968 6.45e-45 174.0 COG1947@1|root,COG1947@2|Bacteria,1ZTM9@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N CMS2_k127_205111_12 1379270.AUXF01000005_gene558 7.839e-61 224.0 COG0392@1|root,COG0392@2|Bacteria,1ZT5W@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS2_k127_205111_18 861299.J421_2970 3.337e-16 93.0 2CB0K@1|root,343GC@2|Bacteria,1ZU4A@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - Hpt CMS2_k127_205111_10 861299.J421_2971 1.36e-84 287.0 COG0854@1|root,COG0854@2|Bacteria,1ZSPZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ CMS2_k127_205111_21 1379270.AUXF01000005_gene561 2.301e-05 53.0 28ZEQ@1|root,2ZM6A@2|Bacteria,1ZU2C@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_205111_17 379066.GAU_1249 3.33e-35 146.0 COG0346@1|root,COG0346@2|Bacteria,1ZTMU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 CMS2_k127_205111_16 379066.GAU_1250 7.241e-36 138.0 COG3118@1|root,COG3118@2|Bacteria,1ZTS0@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Thioredoxin-like domain - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin CMS2_k127_205111_11 1183438.GKIL_1263 6.464e-62 223.0 COG0313@1|root,COG0313@2|Bacteria,1G0IF@1117|Cyanobacteria 1117|Cyanobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase CMS2_k127_205111_9 861299.J421_2976 1.279e-91 306.0 COG1657@1|root,COG1657@2|Bacteria,1ZSPV@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 CMS2_k127_205111_8 1379270.AUXF01000005_gene566 1.375e-92 341.0 COG1196@1|root,COG1196@2|Bacteria,1ZSU8@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - CMS2_k127_205111_15 861299.J421_2978 8.48e-41 170.0 COG1729@1|root,COG1729@2|Bacteria,1ZTBJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - - CMS2_k127_205111_2 379066.GAU_1255 1.128e-150 488.0 2CD20@1|root,2Z7SQ@2|Bacteria,1ZTFE@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_205111_0 861299.J421_2981 1.461e-266 846.0 COG1199@1|root,COG2003@1|root,COG1199@2|Bacteria,COG2003@2|Bacteria,1ZT1S@142182|Gemmatimonadetes 142182|Gemmatimonadetes L HELICc2 - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - Helicase_C_2,RadC CMS2_k127_205111_6 161156.JQKW01000008_gene512 2.033e-103 352.0 COG0436@1|root,COG0436@2|Bacteria,2GGY5@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Aminotransferase class I and II - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_205111_19 861299.J421_2984 1.553e-09 68.0 2FFNT@1|root,347K5@2|Bacteria,1ZTY9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_205111_1 861299.J421_4263 2.507e-185 596.0 COG2234@1|root,COG2234@2|Bacteria,1ZT06@142182|Gemmatimonadetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS2_k127_205111_3 379066.GAU_1259 2.003e-125 415.0 COG0008@1|root,COG0008@2|Bacteria,1ZSSX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c CMS2_k127_205111_13 661478.OP10G_2217 1.701e-57 217.0 COG3488@1|root,COG3488@2|Bacteria 2|Bacteria C Di-haem oxidoreductase, putative peroxidase - - - - - - - - - - - - DHOR CMS2_k127_205111_7 742733.HMPREF9469_01665 6.817e-95 329.0 COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,247UX@186801|Clostridia,222DW@1506553|Lachnoclostridium 186801|Clostridia C Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF CMS2_k127_205111_5 1297570.MESS4_30017 3.637e-113 377.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TVAX@28211|Alphaproteobacteria,43PSD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS2_k127_205111_4 861299.J421_5972 3.09e-125 414.0 2BS4J@1|root,32M5G@2|Bacteria,1ZUJX@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_205111_20 266117.Rxyl_2515 1.684e-06 57.0 COG3328@1|root,COG3328@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - Transposase_mut CMS2_k127_2142052_1 1499967.BAYZ01000115_gene2932 7.905e-155 496.0 COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2NP28@2323|unclassified Bacteria 2|Bacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.1,2.1.2.10,2.2.1.8 ko:K00600,ko:K00605,ko:K18847 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R01221,R02300,R04125,R09099 RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C,SHMT CMS2_k127_2142052_3 1144275.COCOR_01591 1.953e-36 153.0 COG0457@1|root,COG2819@1|root,COG0457@2|Bacteria,COG2819@2|Bacteria,1R54Q@1224|Proteobacteria 1224|Proteobacteria S hydrolase of the alpha beta superfamily - - - ko:K07017 - - - - ko00000 - - - Esterase CMS2_k127_2142052_4 402777.KB235903_gene1948 5.904e-11 68.0 COG1943@1|root,COG1943@2|Bacteria,1G5SV@1117|Cyanobacteria,1HBAQ@1150|Oscillatoriales 1117|Cyanobacteria L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp CMS2_k127_2142052_0 1499967.BAYZ01000151_gene1666 7.918e-191 616.0 COG1132@1|root,COG1132@2|Bacteria,2NNP8@2323|unclassified Bacteria 2|Bacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran CMS2_k127_2142052_2 926569.ANT_01500 1.385e-147 480.0 COG1132@1|root,COG1132@2|Bacteria,2G5RC@200795|Chloroflexi 200795|Chloroflexi P ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran CMS2_k127_2143157_2 477184.KYC_14782 2.726e-30 125.0 COG1846@1|root,COG1846@2|Bacteria,1RF3U@1224|Proteobacteria 1224|Proteobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - MarR CMS2_k127_2143157_1 469383.Cwoe_0090 1.05e-44 168.0 COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4CQ9B@84995|Rubrobacteria 84995|Rubrobacteria K Uncharacterized ACR, COG1678 - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 CMS2_k127_2143157_0 349521.HCH_03207 0.0 1265.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1XHQB@135619|Oceanospirillales 135619|Oceanospirillales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase CMS2_k127_2143157_3 926550.CLDAP_20240 2.015e-20 94.0 COG1669@1|root,COG1669@2|Bacteria,2G76P@200795|Chloroflexi 200795|Chloroflexi L PFAM DNA polymerase, beta domain protein region - - - ko:K07075 - - - - ko00000 - - - NTP_transf_2 CMS2_k127_2155086_4 1379270.AUXF01000007_gene968 1.45e-75 257.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene968|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_2155086_5 861299.J421_3739 1.373e-67 257.0 COG0515@1|root,COG5184@1|root,COG0515@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity - - - - - - - - - - - - Big_2,Flg_new,RCC1,RCC1_2 CMS2_k127_2155086_7 1379270.AUXF01000002_gene1585 3.777e-29 118.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase CMS2_k127_2155086_1 521045.Kole_0614 2.314e-147 489.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - - ko:K06889,ko:K07214 - - - - ko00000 - - - Esterase,Malectin,Peptidase_S9 CMS2_k127_2155086_0 861299.J421_5759 3.789e-162 537.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_2155086_2 861299.J421_0887 5.212e-116 406.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_2155086_10 7994.ENSAMXP00000011719 0.0008567 50.0 KOG1451@1|root,KOG1451@2759|Eukaryota,38BGM@33154|Opisthokonta,3BE5X@33208|Metazoa,3D3I6@33213|Bilateria,47ZMV@7711|Chordata,48VBW@7742|Vertebrata,49UHG@7898|Actinopterygii 33208|Metazoa T Oligophrenin 1 OPHN1 GO:0000902,GO:0000904,GO:0001738,GO:0002009,GO:0003674,GO:0003779,GO:0005096,GO:0005102,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0006810,GO:0006897,GO:0006928,GO:0006929,GO:0006930,GO:0006935,GO:0006996,GO:0007010,GO:0007154,GO:0007163,GO:0007165,GO:0007275,GO:0007399,GO:0007409,GO:0007411,GO:0007417,GO:0007420,GO:0008047,GO:0008092,GO:0008150,GO:0008289,GO:0009605,GO:0009653,GO:0009888,GO:0009892,GO:0009894,GO:0009895,GO:0009966,GO:0009987,GO:0010605,GO:0010646,GO:0015629,GO:0016043,GO:0016192,GO:0016477,GO:0019222,GO:0021533,GO:0021549,GO:0021575,GO:0021587,GO:0021681,GO:0021683,GO:0021684,GO:0021695,GO:0021696,GO:0021697,GO:0021707,GO:0021895,GO:0021953,GO:0022008,GO:0022037,GO:0022607,GO:0023051,GO:0023052,GO:0030010,GO:0030029,GO:0030030,GO:0030031,GO:0030036,GO:0030100,GO:0030154,GO:0030162,GO:0030182,GO:0030234,GO:0030424,GO:0030425,GO:0030695,GO:0030855,GO:0030859,GO:0030900,GO:0030902,GO:0031175,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032879,GO:0032989,GO:0032990,GO:0033267,GO:0034329,GO:0034330,GO:0035023,GO:0035088,GO:0035089,GO:0035254,GO:0035255,GO:0036465,GO:0036477,GO:0040011,GO:0042176,GO:0042177,GO:0042221,GO:0042330,GO:0042995,GO:0043005,GO:0043085,GO:0043087,GO:0043167,GO:0043168,GO:0043195,GO:0043197,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043547,GO:0043679,GO:0044085,GO:0044093,GO:0044306,GO:0044309,GO:0044424,GO:0044444,GO:0044456,GO:0044463,GO:0044464,GO:0045197,GO:0045198,GO:0045202,GO:0045861,GO:0046578,GO:0048468,GO:0048488,GO:0048513,GO:0048519,GO:0048523,GO:0048583,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048729,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050789,GO:0050790,GO:0050794,GO:0050804,GO:0050896,GO:0051049,GO:0051056,GO:0051128,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051336,GO:0051345,GO:0051641,GO:0051649,GO:0051674,GO:0051716,GO:0051966,GO:0060255,GO:0060322,GO:0060429,GO:0060589,GO:0060627,GO:0061136,GO:0061162,GO:0061245,GO:0061339,GO:0061564,GO:0065007,GO:0065009,GO:0071840,GO:0080090,GO:0090162,GO:0097447,GO:0097458,GO:0097485,GO:0098657,GO:0098772,GO:0098793,GO:0098794,GO:0099003,GO:0099177,GO:0099504,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:0120039,GO:0150034,GO:1901799,GO:1902531,GO:1903050,GO:1903051,GO:1903362,GO:1903363 - ko:K20650 - - - - ko00000,ko04131 - - - BAR_3,PH,RhoGAP CMS2_k127_2155086_6 1294142.CINTURNW_1927 4.519e-36 153.0 2BCB5@1|root,325WF@2|Bacteria,1URWB@1239|Firmicutes,24XYD@186801|Clostridia,36QUA@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - CMS2_k127_2155086_9 234267.Acid_1736 1.036e-20 98.0 COG1695@1|root,COG1695@2|Bacteria,3Y5FM@57723|Acidobacteria 57723|Acidobacteria K PFAM transcriptional regulator PadR family protein - - - - - - - - - - - - PadR CMS2_k127_2155086_3 861299.J421_6141 8.407e-113 398.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6141|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_2155086_8 1047013.AQSP01000114_gene690 1.98e-25 111.0 COG1413@1|root,COG2020@1|root,COG1413@2|Bacteria,COG2020@2|Bacteria,2NRRZ@2323|unclassified Bacteria 2|Bacteria C PBS lyase HEAT-like repeat - - 1.3.1.21,1.3.1.70 ko:K00213,ko:K00222 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00101 R01451,R01456,R05639,R07483,R07487,R07492 RC00138,RC01441 ko00000,ko00001,ko00002,ko01000 - - - DUF1295,ERG4_ERG24,HEAT_2,HEAT_PBS,PEMT CMS2_k127_2160682_0 1123368.AUIS01000023_gene933 5.304e-166 546.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales 225057|Acidithiobacillales T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GGDEF,PAS,PAS_4 CMS2_k127_2160682_1 382464.ABSI01000012_gene2198 6.749e-57 210.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C CMS2_k127_2177603_15 1254432.SCE1572_04190 5.86e-26 113.0 COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria 1224|Proteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC CMS2_k127_2177603_10 1298867.AUES01000021_gene3207 2.494e-67 244.0 COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria,3JT7A@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_2177603_12 1047013.AQSP01000051_gene2576 1.231e-42 169.0 COG2220@1|root,COG2220@2|Bacteria,2NRBH@2323|unclassified Bacteria 2|Bacteria S Beta-lactamase superfamily domain folD4 - - - - - - - - - - - Lactamase_B_3 CMS2_k127_2177603_2 661478.OP10G_0324 5.21e-150 484.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - - - - - - - - - - - Aminotran_1_2 CMS2_k127_2177603_1 1379270.AUXF01000002_gene1544 1.398e-184 593.0 COG3653@1|root,COG3653@2|Bacteria 2|Bacteria Q N-Acyl-D-aspartate D-glutamate deacylase - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 CMS2_k127_2177603_0 1379270.AUXF01000001_gene2513 2.564e-210 671.0 COG0154@1|root,COG0154@2|Bacteria,1ZT8R@142182|Gemmatimonadetes 2|Bacteria J Amidase gatA - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase CMS2_k127_2177603_21 1336243.JAEA01000010_gene3491 0.0002445 46.0 COG4319@1|root,COG4319@2|Bacteria,1N5R1@1224|Proteobacteria,2TVTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS2_k127_2177603_19 1079460.ATTQ01000001_gene5859 9.006e-06 55.0 COG4319@1|root,COG4319@2|Bacteria,1NCYK@1224|Proteobacteria,2UZTR@28211|Alphaproteobacteria,4BJYC@82115|Rhizobiaceae 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - - CMS2_k127_2177603_5 1254432.SCE1572_02795 5.223e-110 376.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS2_k127_2177603_13 379066.GAU_3083 9.055e-29 134.0 2EXVN@1|root,33R4S@2|Bacteria,1ZTD4@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_2177603_11 86416.Clopa_3686 2.989e-53 200.0 COG1600@1|root,COG1600@2|Bacteria,1V0A3@1239|Firmicutes,249D6@186801|Clostridia 186801|Clostridia C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - - - - - - - - - - - - CMS2_k127_2177603_17 1123228.AUIH01000028_gene460 9.266e-10 71.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1XHTC@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM CMS2_k127_2177603_8 448385.sce4001 1.566e-71 258.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - O-antigen_lig,Sulfotransfer_3 CMS2_k127_2177603_14 414684.RC1_1660 3.048e-27 124.0 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,2TVNU@28211|Alphaproteobacteria,2JRTM@204441|Rhodospirillales 204441|Rhodospirillales M COG0451 Nucleoside-diphosphate-sugar epimerases - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase CMS2_k127_2177603_4 570268.ANBB01000038_gene3351 4.767e-134 454.0 COG2192@1|root,COG2192@2|Bacteria,2GJHV@201174|Actinobacteria,4EHPF@85012|Streptosporangiales 201174|Actinobacteria O Carbamoyltransferase C-terminus nolO - - ko:K00612,ko:K16035 ko01051,ko01052,ko01130,map01051,map01052,map01130 - R09853,R09858 RC00055,RC02840 ko00000,ko00001,ko01000 - - - Carbam_trans_C,Carbam_trans_N CMS2_k127_2177603_16 221359.RS9916_34632 8.911e-22 107.0 COG2227@1|root,COG2227@2|Bacteria,1G0TK@1117|Cyanobacteria,1GZNY@1129|Synechococcus 1117|Cyanobacteria H COG0500 SAM-dependent methyltransferases - - - - - - - - - - - - Methyltransf_12,Methyltransf_31 CMS2_k127_2177603_6 439235.Dalk_4756 1.696e-83 296.0 COG1032@1|root,COG1032@2|Bacteria,1NRWP@1224|Proteobacteria,42S72@68525|delta/epsilon subdivisions,2WNA6@28221|Deltaproteobacteria,2MKAP@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM CMS2_k127_2177603_7 1380346.JNIH01000052_gene6931 3.299e-74 262.0 COG3882@1|root,COG3882@2|Bacteria,2GNIM@201174|Actinobacteria 201174|Actinobacteria Q HAD-superfamily phosphatase, subfamily IIIC - - - - - - - - - - - - - CMS2_k127_2177603_20 63737.Npun_R3441 1.359e-05 54.0 COG0236@1|root,COG0236@2|Bacteria,1G854@1117|Cyanobacteria,1HT7T@1161|Nostocales 1117|Cyanobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding CMS2_k127_2177603_3 1267534.KB906759_gene1822 3.828e-141 475.0 COG2409@1|root,COG2409@2|Bacteria 2|Bacteria D Drug exporters of the RND superfamily mmpL3 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - ko:K06994,ko:K07003,ko:K20466,ko:K20470 - - - - ko00000,ko02000 2.A.6.5.5,2.A.6.5.6 - - MMPL CMS2_k127_2177603_9 309799.DICTH_0179 2.442e-67 248.0 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - ko:K20952 ko05111,map05111 - - - ko00000,ko00001 - - - Beta-prism_lec,PQQ_2,PQQ_3,Pkinase,VCBS CMS2_k127_2177603_18 537013.CLOSTMETH_03352 1.489e-09 70.0 COG2247@1|root,COG5492@1|root,COG2247@2|Bacteria,COG5492@2|Bacteria,1UVV0@1239|Firmicutes,25KN8@186801|Clostridia,3WQEX@541000|Ruminococcaceae 186801|Clostridia M domain, Protein - - - - - - - - - - - - - CMS2_k127_2272581_0 1123376.AUIU01000012_gene1512 0.0 1536.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,3J0TJ@40117|Nitrospirae 40117|Nitrospirae F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 CMS2_k127_2272581_1 1379270.AUXF01000002_gene1345 3.015e-101 344.0 COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_22988_7 290512.Paes_0658 2.042e-32 128.0 COG1544@1|root,COG1544@2|Bacteria,1FFAZ@1090|Chlorobi 1090|Chlorobi J Sigma 54 modulation protein / S30EA ribosomal protein - - - - - - - - - - - - Ribosomal_S30AE CMS2_k127_22988_4 1122221.JHVI01000008_gene2339 1.734e-44 174.0 COG1961@1|root,COG1961@2|Bacteria 2|Bacteria L recombinase activity - - - - - - - - - - - - Recombinase,Resolvase CMS2_k127_22988_2 443143.GM18_2891 6.279e-94 317.0 COG4227@1|root,COG4227@2|Bacteria,1MU8I@1224|Proteobacteria,42N43@68525|delta/epsilon subdivisions,2WM7N@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Domain of unknown function (DUF1738) - - - - - - - - - - - - DUF1738,Toprim_3 CMS2_k127_22988_10 883126.HMPREF9710_00161 1.331e-06 59.0 COG5563@1|root,COG5563@2|Bacteria,1R9G5@1224|Proteobacteria,2VNH0@28216|Betaproteobacteria,475YZ@75682|Oxalobacteraceae 28216|Betaproteobacteria S extracellular repeat, HAF family - - - - - - - - - - - - Autotransporter CMS2_k127_22988_8 1047013.AQSP01000131_gene1844 6.301e-14 81.0 COG1238@1|root,COG1238@2|Bacteria 2|Bacteria I metal cluster binding yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - SNARE_assoc CMS2_k127_22988_3 861299.J421_0060 6.712e-60 228.0 COG1524@1|root,COG1524@2|Bacteria,1ZT33@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest CMS2_k127_22988_5 861299.J421_4135 4.88e-44 164.0 COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_22988_1 861299.J421_0887 1.888e-133 458.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_22988_9 59374.Fisuc_2472 3.499e-07 57.0 COG4704@1|root,COG4704@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Fib_succ_major CMS2_k127_22988_0 1121920.AUAU01000007_gene543 9.196e-171 542.0 COG0604@1|root,COG0604@2|Bacteria,3Y4X4@57723|Acidobacteria 57723|Acidobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N CMS2_k127_22988_6 926566.Terro_0160 2.712e-38 146.0 COG5207@1|root,COG5207@2|Bacteria,3Y5BD@57723|Acidobacteria,2JJT0@204432|Acidobacteriia 204432|Acidobacteriia O Zn-finger in ubiquitin-hydrolases and other protein - - - - - - - - - - - - zf-UBP CMS2_k127_2299799_1 404589.Anae109_3006 7.439e-68 239.0 COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2Z22B@29|Myxococcales 28221|Deltaproteobacteria GM NAD(P)H-binding - - - - - - - - - - - - DUF2867,NAD_binding_10 CMS2_k127_2299799_4 1121104.AQXH01000003_gene404 8.341e-12 68.0 COG0415@1|root,COG0415@2|Bacteria 2|Bacteria L Belongs to the DNA photolyase family phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 CMS2_k127_2299799_3 309807.SRU_2815 2.176e-25 106.0 COG2336@1|root,COG2336@2|Bacteria 2|Bacteria T PFAM SpoVT AbrB - - - ko:K07172,ko:K18842 - - - - ko00000,ko02048 - - - MazE_antitoxin CMS2_k127_2299799_2 652103.Rpdx1_4395 3.134e-38 149.0 COG3654@1|root,COG3654@2|Bacteria,1N1FW@1224|Proteobacteria,2U8GF@28211|Alphaproteobacteria,3JYGY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Fic/DOC family doc - - ko:K07341 - - - - ko00000,ko02048 - - - Fic CMS2_k127_2299799_0 288000.BBta_7802 1.445e-68 242.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,3JVXA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 CMS2_k127_2312601_3 1048983.EL17_05565 2.872e-19 87.0 COG2936@1|root,COG2936@2|Bacteria,4NFFB@976|Bacteroidetes,47JKV@768503|Cytophagia 976|Bacteroidetes S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 CMS2_k127_2312601_2 1379270.AUXF01000006_gene150 1.382e-42 162.0 2DEWU@1|root,2ZPJP@2|Bacteria,1ZUFA@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_2312601_0 1278073.MYSTI_04478 2.117e-91 315.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MCR@68525|delta/epsilon subdivisions,2WJXI@28221|Deltaproteobacteria 28221|Deltaproteobacteria EK PFAM aminotransferase class I and II lysN - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 CMS2_k127_2312601_1 370438.PTH_1540 1.071e-52 196.0 COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,264MQ@186807|Peptococcaceae 186801|Clostridia C Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM-like protein - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 CMS2_k127_2312601_4 1125863.JAFN01000001_gene1570 7.035e-09 57.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42S8R@68525|delta/epsilon subdivisions,2WNW6@28221|Deltaproteobacteria 28221|Deltaproteobacteria C [2Fe-2S] binding domain - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 CMS2_k127_2313042_85 1047013.AQSP01000133_gene2124 8.919e-10 62.0 COG1921@1|root,COG1921@2|Bacteria 2|Bacteria E L-seryl-tRNASec selenium transferase activity - - 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Aminotran_5,SelA CMS2_k127_2313042_42 861299.J421_1590 4.449e-55 205.0 COG0083@1|root,COG0083@2|Bacteria 2|Bacteria E homoserine kinase activity thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620 GHMP_kinases_C,GHMP_kinases_N CMS2_k127_2313042_81 204669.Acid345_1586 1.502e-12 74.0 2F7F1@1|root,33ZVU@2|Bacteria,3Y85X@57723|Acidobacteria,2JN8D@204432|Acidobacteriia 204432|Acidobacteriia S Protein of unknown function (DUF1569) - - - - - - - - - - - - DUF1569,DinB_2 CMS2_k127_2313042_55 1122137.AQXF01000003_gene2416 9.091e-36 143.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2UGES@28211|Alphaproteobacteria 28211|Alphaproteobacteria J PFAM Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP CMS2_k127_2313042_83 479433.Caci_1944 3.732e-11 66.0 2DG6U@1|root,2ZURF@2|Bacteria,2HCGM@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS2_k127_2313042_69 379066.GAU_0167 9.227e-21 93.0 COG2924@1|root,COG2924@2|Bacteria,1ZTWZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic CMS2_k127_2313042_56 1408473.JHXO01000006_gene1032 1.051e-33 134.0 2DNW1@1|root,32ZFG@2|Bacteria,4NUV5@976|Bacteroidetes,2G1AY@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_2313042_64 255470.cbdbA1083 3.145e-27 117.0 COG1695@1|root,COG1695@2|Bacteria,2GB0E@200795|Chloroflexi,34DPJ@301297|Dehalococcoidia 301297|Dehalococcoidia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_2313042_78 1382359.JIAL01000001_gene336 9.766e-15 79.0 COG2259@1|root,COG2259@2|Bacteria 2|Bacteria S methylamine metabolic process doxX - 1.6.99.3 ko:K03885,ko:K15977 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - DoxX CMS2_k127_2313042_67 1123253.AUBD01000005_gene130 6.03e-22 108.0 COG0265@1|root,COG0265@2|Bacteria,1PCJA@1224|Proteobacteria,1SXM8@1236|Gammaproteobacteria,1X6DM@135614|Xanthomonadales 135614|Xanthomonadales O PDZ domain - - - - - - - - - - - - PDZ_2 CMS2_k127_2313042_59 935863.AWZR01000007_gene217 3.63e-32 132.0 COG1595@1|root,COG1595@2|Bacteria,1QDHS@1224|Proteobacteria,1SS07@1236|Gammaproteobacteria,1X6DE@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_2313042_1 379066.GAU_0518 0.0 1034.0 COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 CMS2_k127_2313042_58 1408254.T458_09170 3.27e-32 145.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,26QU5@186822|Paenibacillaceae 91061|Bacilli NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 CMS2_k127_2313042_22 379066.GAU_0192 4.123e-86 301.0 COG0075@1|root,COG0075@2|Bacteria,1ZTF3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS2_k127_2313042_37 1322246.BN4_10824 1.074e-61 220.0 COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,43BKJ@68525|delta/epsilon subdivisions,2WIZJ@28221|Deltaproteobacteria,2M9AT@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 CMS2_k127_2313042_17 379066.GAU_0517 1.507e-119 395.0 COG1446@1|root,COG1446@2|Bacteria,1ZTAQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Asparaginase - - 3.5.1.26 ko:K01444 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Asparaginase_2 CMS2_k127_2313042_74 215803.DB30_7744 1.05e-17 96.0 COG4775@1|root,COG4775@2|Bacteria,1PJVQ@1224|Proteobacteria,4377F@68525|delta/epsilon subdivisions,2X28C@28221|Deltaproteobacteria,2YWK9@29|Myxococcales 28221|Deltaproteobacteria M Surface antigen - - - - - - - - - - - - Bac_surface_Ag CMS2_k127_2313042_52 861299.J421_3035 6.259e-41 158.0 COG0526@1|root,COG0526@2|Bacteria,1ZU4M@142182|Gemmatimonadetes 142182|Gemmatimonadetes CO Thioredoxin - - - - - - - - - - - - Thioredoxin_9 CMS2_k127_2313042_79 1132442.KB889752_gene1918 1.18e-14 81.0 COG1309@1|root,COG1309@2|Bacteria,1V95E@1239|Firmicutes,4HJIZ@91061|Bacilli,1ZDJZ@1386|Bacillus 91061|Bacilli K Transcriptional regulator - - - ko:K22106 - - - - ko00000,ko03000 - - - TetR_C_10,TetR_N CMS2_k127_2313042_9 1047013.AQSP01000132_gene1721 7.221e-194 614.0 COG0733@1|root,COG0733@2|Bacteria,2NNP4@2323|unclassified Bacteria 2|Bacteria S Sodium:neurotransmitter symporter family yocR - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF CMS2_k127_2313042_32 448385.sce0038 4.706e-67 242.0 COG0393@1|root,COG0515@1|root,COG0393@2|Bacteria,COG0515@2|Bacteria,1QA6R@1224|Proteobacteria,439IS@68525|delta/epsilon subdivisions,2X4V7@28221|Deltaproteobacteria,2YZNY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_2313042_15 861299.J421_2398 1.07e-139 459.0 COG0745@1|root,COG2199@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1ZT7F@142182|Gemmatimonadetes 142182|Gemmatimonadetes T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg CMS2_k127_2313042_30 543632.JOJL01000008_gene5931 1.69e-74 262.0 COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4DB0R@85008|Micromonosporales 201174|Actinobacteria E Threonine dehydratase ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,PALP CMS2_k127_2313042_0 861299.J421_2396 0.0 1114.0 COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV CMS2_k127_2313042_14 1047013.AQSP01000102_gene979 5.442e-156 533.0 COG0841@1|root,COG0841@2|Bacteria,2NQF8@2323|unclassified Bacteria 2|Bacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran CMS2_k127_2313042_7 1304284.L21TH_0012 2.719e-210 692.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,36F39@31979|Clostridiaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran CMS2_k127_2313042_80 379066.GAU_1148 1.616e-14 87.0 COG1538@1|root,COG1538@2|Bacteria,1ZSMB@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS2_k127_2313042_41 1047013.AQSP01000079_gene2044 7.129e-57 214.0 COG0845@1|root,COG0845@2|Bacteria,2NR3D@2323|unclassified Bacteria 2|Bacteria M Biotin-lipoyl like - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS2_k127_2313042_20 861299.J421_2390 1.552e-114 379.0 COG0604@1|root,COG0604@2|Bacteria,1ZT6R@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N CMS2_k127_2313042_61 1499967.BAYZ01000090_gene4936 8.793e-31 141.0 COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria 2|Bacteria U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS2_k127_2313042_53 1137271.AZUM01000008_gene2068 1.257e-40 168.0 COG1228@1|root,COG1228@2|Bacteria,2I98N@201174|Actinobacteria,4E1HT@85010|Pseudonocardiales 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 CMS2_k127_2313042_50 1379270.AUXF01000002_gene1806 8.336e-46 172.0 COG0328@1|root,COG0328@2|Bacteria,1ZTI8@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H CMS2_k127_2313042_70 398720.MED217_16915 2.488e-20 97.0 COG2131@1|root,COG2131@2|Bacteria,4NM48@976|Bacteroidetes,1I1AE@117743|Flavobacteriia,2XJC2@283735|Leeuwenhoekiella 976|Bacteroidetes F MafB19-like deaminase comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 CMS2_k127_2313042_63 861299.J421_2370 1.18e-27 121.0 2F95J@1|root,341H1@2|Bacteria,1ZTZZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_2313042_23 880073.Calab_1132 2.115e-83 290.0 COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria 2|Bacteria O prohibitin homologues hflC - - - - - - - - - - - Band_7 CMS2_k127_2313042_60 861299.J421_2367 5.848e-31 133.0 2FK9E@1|root,34BX2@2|Bacteria,1ZTYM@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_2313042_26 861299.J421_3737 4.111e-81 285.0 COG0644@1|root,COG0644@2|Bacteria,1ZV85@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Lycopene cyclase protein - - 1.3.1.111,1.3.1.83,1.3.99.38 ko:K10960,ko:K21401 ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110 - R02063,R08754,R08755,R08756,R11226,R11518 RC00212,RC00522,RC01823 ko00000,ko00001,ko01000 - - - FAD_binding_3 CMS2_k127_2313042_34 861299.J421_2363 7.205e-63 230.0 COG1562@1|root,COG1562@2|Bacteria,1ZT7M@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Squalene/phytoene synthase - - 2.5.1.21 ko:K00801 ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130 - R00702,R02872,R06223 RC00362,RC00796,RC02839 ko00000,ko00001,ko01000,ko01006 - - - SQS_PSY CMS2_k127_2313042_45 926560.KE387027_gene334 4.923e-51 186.0 COG0262@1|root,COG0262@2|Bacteria,1WMN7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis - - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 CMS2_k127_2313042_4 1379270.AUXF01000002_gene1793 4.294e-261 822.0 COG0480@1|root,COG0480@2|Bacteria,1ZTFA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU CMS2_k127_2313042_57 187303.BN69_0293 9.548e-33 132.0 COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,36YV8@31993|Methylocystaceae 28211|Alphaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX CMS2_k127_2313042_77 1230457.C476_03743 6.75e-15 86.0 COG0589@1|root,arCOG00449@2157|Archaea,2XVPB@28890|Euryarchaeota,23SHQ@183963|Halobacteria 183963|Halobacteria T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp CMS2_k127_2313042_40 671143.DAMO_3124 1.011e-58 222.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,SpoIIE,sCache_3_2 CMS2_k127_2313042_31 1485545.JQLW01000006_gene531 1.546e-70 246.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria 1224|Proteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C CMS2_k127_2313042_48 269799.Gmet_3382 3.127e-47 187.0 COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,1QTV1@1224|Proteobacteria,43BSP@68525|delta/epsilon subdivisions,2X7EK@28221|Deltaproteobacteria,43W43@69541|Desulfuromonadales 28221|Deltaproteobacteria T histidine kinase, HAMP - - 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA CMS2_k127_2313042_75 395963.Bind_0907 2.081e-17 87.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,3N9Q5@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - Cytochrome_CBB3,GSDH CMS2_k127_2313042_2 385682.AFSL01000102_gene55 3.679e-299 934.0 COG0370@1|root,COG0370@2|Bacteria,4NEII@976|Bacteroidetes,2FNKT@200643|Bacteroidia,3XJ70@558415|Marinilabiliaceae 976|Bacteroidetes P FeoA - - - - - - - - - - - - FeoA,FeoB_C,FeoB_N,Gate CMS2_k127_2313042_25 869213.JCM21142_41393 2.743e-81 283.0 COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,4NGUP@976|Bacteroidetes 976|Bacteroidetes K iron dependent repressor - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,FeoA CMS2_k127_2313042_12 880073.Calab_3483 8.803e-184 586.0 COG3033@1|root,COG3033@2|Bacteria,2NNZV@2323|unclassified Bacteria 2|Bacteria E Beta-eliminating lyase tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS2_k127_2313042_66 443143.GM18_2605 4.192e-23 102.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM Cold-shock protein, DNA-binding - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS2_k127_2313042_13 313606.M23134_06842 1.02e-182 581.0 COG0673@1|root,COG0673@2|Bacteria,4NF3G@976|Bacteroidetes,47MH7@768503|Cytophagia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold nagA - - - - - - - - - - - GFO_IDH_MocA CMS2_k127_2313042_3 234267.Acid_4902 7.025e-286 900.0 COG5549@1|root,COG5549@2|Bacteria,3Y2IY@57723|Acidobacteria 57723|Acidobacteria O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 CMS2_k127_2313042_65 552811.Dehly_0265 5.376e-25 107.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 CMS2_k127_2313042_24 572478.Vdis_0122 4.786e-83 282.0 COG0500@1|root,arCOG01773@2157|Archaea,2XRWU@28889|Crenarchaeota 28889|Crenarchaeota Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 CMS2_k127_2313042_51 1278073.MYSTI_01791 1.659e-45 169.0 COG0251@1|root,COG0251@2|Bacteria 2|Bacteria J oxidation-reduction process - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP CMS2_k127_2313042_68 861299.J421_0117 4.521e-21 109.0 COG3325@1|root,COG3325@2|Bacteria 2|Bacteria G chitin binding - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - Calx-beta,Glyco_hydro_18,PA14,PKD,fn3 CMS2_k127_2313042_39 448385.sce3387 2.226e-59 233.0 COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales 28221|Deltaproteobacteria S cellulose binding - - - - - - - - - - - - - CMS2_k127_2313042_87 1034769.KB910518_gene3376 2.026e-09 71.0 COG3250@1|root,COG3867@1|root,COG4733@1|root,COG5492@1|root,COG3250@2|Bacteria,COG3867@2|Bacteria,COG4733@2|Bacteria,COG5492@2|Bacteria,1UNMG@1239|Firmicutes,4IUI8@91061|Bacilli,277MP@186822|Paenibacillaceae 91061|Bacilli GN Bacterial Ig-like domain (group 2) - - - - - - - - - - - - Big_2,SLH CMS2_k127_2313042_19 204669.Acid345_3014 2.81e-117 410.0 COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia 204432|Acidobacteriia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg CMS2_k127_2313042_73 1123399.AQVE01000024_gene2813 8.958e-19 101.0 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB CMS2_k127_2313042_11 861299.J421_0444 1.056e-187 599.0 COG0174@1|root,COG0174@2|Bacteria,1ZSYQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glutamine synthetase, beta-Grasp domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N CMS2_k127_2313042_71 379066.GAU_0201 3.872e-19 98.0 2F3M0@1|root,33WE8@2|Bacteria,1ZTTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_2313042_21 1379270.AUXF01000002_gene1474 5.087e-95 323.0 COG3437@1|root,COG3437@2|Bacteria,1ZTD3@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HD domain - - - - - - - - - - - - HD,Response_reg CMS2_k127_2313042_91 1192868.CAIU01000013_gene1578 0.0001779 53.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria,43HQG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S 40-residue YVTN family beta-propeller repeat MA20_34510 - - - - - - - - - - - Cytochrom_D1,Lactonase CMS2_k127_2313042_88 861299.J421_4437 2.258e-09 64.0 COG4970@1|root,COG4970@2|Bacteria,1ZU5N@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Tfp pilus assembly protein FimT - - - - - - - - - - - - - CMS2_k127_2313042_92 1463853.JOHW01000058_gene1945 0.0002461 53.0 COG0457@1|root,COG0457@2|Bacteria,2INUN@201174|Actinobacteria 201174|Actinobacteria G sequence-specific DNA binding - - - - - - - - - - - - NB-ARC,TPR_12,TPR_7 CMS2_k127_2313042_76 861299.J421_1142 5.608e-15 85.0 COG2207@1|root,COG2207@2|Bacteria,1ZTPX@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 CMS2_k127_2313042_89 1160718.SU9_02409 6.891e-07 57.0 COG0745@1|root,COG0745@2|Bacteria,2GJRR@201174|Actinobacteria 201174|Actinobacteria T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain afsQ1 - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_2313042_54 379066.GAU_0196 5.52e-37 152.0 COG0789@1|root,COG0789@2|Bacteria,1ZTHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes K MerR HTH family regulatory protein - - - - - - - - - - - - MerR_1 CMS2_k127_2313042_44 521045.Kole_1143 9.023e-54 195.0 COG1704@1|root,COG1704@2|Bacteria,2GCV5@200918|Thermotogae 200918|Thermotogae S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA CMS2_k127_2313042_38 266117.Rxyl_0345 4.551e-60 224.0 COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CQF1@84995|Rubrobacteria 84995|Rubrobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 CMS2_k127_2313042_27 864051.BurJ1DRAFT_3799 2.544e-79 286.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,2W5VT@28216|Betaproteobacteria 28216|Betaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase CMS2_k127_2313042_29 861299.J421_0496 4.194e-75 263.0 COG3481@1|root,COG3481@2|Bacteria 2|Bacteria D metal-dependent phosphohydrolase, HD sub domain cbf - - ko:K03698 - - - - ko00000,ko01000,ko03019 - - - HD,TraI_2,tRNA_anti-codon CMS2_k127_2313042_86 1365176.N186_02260 1.551e-09 65.0 COG1371@1|root,arCOG04055@2157|Archaea,2XQYK@28889|Crenarchaeota 28889|Crenarchaeota J Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - - - - - - - - - - Archease CMS2_k127_2313042_10 1232410.KI421412_gene150 5.503e-192 612.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,43SZD@69541|Desulfuromonadales 28221|Deltaproteobacteria S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB CMS2_k127_2313042_62 1234679.BN424_828 1.64e-28 129.0 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,4H9PI@91061|Bacilli,27F7P@186828|Carnobacteriaceae 91061|Bacilli E Receptor family ligand binding region livJ - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 CMS2_k127_2313042_47 1379270.AUXF01000002_gene1823 1.689e-49 198.0 COG0840@1|root,COG0840@2|Bacteria,1ZSWC@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal CMS2_k127_2313042_36 861299.J421_2921 2.463e-62 222.0 COG0681@1|root,COG0681@2|Bacteria,1ZTQ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 CMS2_k127_2313042_16 379066.GAU_0170 2.712e-132 434.0 COG0823@1|root,COG0823@2|Bacteria,1ZTFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_2313042_5 518766.Rmar_1231 7.401e-232 730.0 COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,1FIW6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Aldehyde dehydrogenase family pruA - 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh CMS2_k127_2313042_84 1047013.AQSP01000131_gene1844 8.32e-10 68.0 COG1238@1|root,COG1238@2|Bacteria 2|Bacteria I metal cluster binding yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - SNARE_assoc CMS2_k127_2313042_33 1075090.GOAMR_48_01310 2.154e-65 238.0 COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4GCNW@85026|Gordoniaceae 201174|Actinobacteria P ATPases associated with a variety of cellular activities cbiO - - ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - ABC_tran CMS2_k127_2313042_82 338966.Ppro_1806 5.067e-12 75.0 COG0619@1|root,COG0619@2|Bacteria,1R2DN@1224|Proteobacteria,43B6A@68525|delta/epsilon subdivisions,2X6JT@28221|Deltaproteobacteria,43S05@69541|Desulfuromonadales 28221|Deltaproteobacteria P Cobalt transport protein nikQ - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ CMS2_k127_2313042_49 643473.KB235930_gene2340 3.909e-47 183.0 COG0310@1|root,COG0310@2|Bacteria,1G40K@1117|Cyanobacteria,1HIGH@1161|Nostocales 1117|Cyanobacteria P PFAM Cobalt uptake substrate-specific transmembrane region cbiM - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM,PDGLE CMS2_k127_2313042_35 1405.DJ92_5164 1.487e-62 219.0 COG1670@1|root,COG1670@2|Bacteria,1V5WS@1239|Firmicutes,4HH37@91061|Bacilli,1ZEZG@1386|Bacillus 91061|Bacilli J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 CMS2_k127_2313042_18 861299.J421_0684 1.666e-119 397.0 COG1301@1|root,COG1301@2|Bacteria,1ZTDM@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF CMS2_k127_2313042_46 1379270.AUXF01000007_gene963 1.068e-50 200.0 COG0006@1|root,COG0006@2|Bacteria,1ZUQY@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminopeptidase P, N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 CMS2_k127_2313042_72 570967.JMLV01000001_gene2678 4.265e-19 94.0 COG5455@1|root,COG5455@2|Bacteria,1N3PU@1224|Proteobacteria,2UGK9@28211|Alphaproteobacteria,2JUR7@204441|Rhodospirillales 204441|Rhodospirillales S response to cobalt ion - - - - - - - - - - - - - CMS2_k127_2313042_6 1379270.AUXF01000002_gene1345 2.748e-231 751.0 COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_2313042_90 1266909.AUAG01000020_gene211 0.0001355 55.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge CMS2_k127_2313042_43 1408473.JHXO01000009_gene3303 3.501e-54 198.0 2DKU7@1|root,30BG5@2|Bacteria,4NNSQ@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - DUF1080 CMS2_k127_2313042_8 234267.Acid_4267 1.137e-204 665.0 COG0577@1|root,COG0577@2|Bacteria,3Y3U3@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_2313042_28 1179773.BN6_52180 1.197e-78 287.0 COG2234@1|root,COG2234@2|Bacteria,2ID08@201174|Actinobacteria,4E2GM@85010|Pseudonocardiales 201174|Actinobacteria S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28,TFR_dimer CMS2_k127_2323850_1 1089547.KB913013_gene3993 4.778e-10 65.0 COG2834@1|root,COG2834@2|Bacteria,4NHV3@976|Bacteroidetes,47K73@768503|Cytophagia 976|Bacteroidetes M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - DUF4292,LolA_like CMS2_k127_2323850_0 379066.GAU_0104 3.015e-103 351.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - - - - - - - - - - Aminotran_5 CMS2_k127_2337132_7 1121405.dsmv_3736 1.568e-11 64.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS2_k127_2337132_2 767817.Desgi_1965 1.376e-122 404.0 COG0183@1|root,COG0183@2|Bacteria,1TRRD@1239|Firmicutes 1239|Firmicutes I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS2_k127_2337132_5 706587.Desti_2451 1.879e-26 113.0 COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria,2MRW8@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc CMS2_k127_2337132_4 1379698.RBG1_1C00001G0904 1.359e-47 182.0 COG1024@1|root,COG1024@2|Bacteria 2|Bacteria I Enoyl-CoA hydratase bamR - 4.2.1.100 ko:K07537 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05597 RC03168 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS2_k127_2337132_0 706587.Desti_1912 0.0 1060.0 COG2414@1|root,COG2414@2|Bacteria,1R5AG@1224|Proteobacteria,42NHF@68525|delta/epsilon subdivisions,2WK3Z@28221|Deltaproteobacteria,2MQUC@213462|Syntrophobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase, N-terminal domain bamB-1 - 1.2.7.5 ko:K03738,ko:K19515 ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200 M00309,M00541 R08571,R10961 RC00242,RC01839 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N CMS2_k127_2337132_3 706587.Desti_1913 1.705e-88 295.0 COG1142@1|root,COG1142@2|Bacteria,1RBG7@1224|Proteobacteria,42R5G@68525|delta/epsilon subdivisions,2WMV5@28221|Deltaproteobacteria,2MR63@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - ko:K19516 ko00362,ko01100,ko01120,map00362,map01100,map01120 M00541 R10961 RC01839 ko00000,ko00001,ko00002,ko01000 - - - - CMS2_k127_2337132_1 1121405.dsmv_2374 2.41e-187 591.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MJHX@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain bamD - - - - - - - - - - - CCG,Fer4_17,Fer4_8 CMS2_k127_2337132_6 56780.SYN_03861 1.975e-20 92.0 COG1148@1|root,COG1148@2|Bacteria 2|Bacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored,Fer2_4,Fer4,Fer4_7,Pyr_redox_2 CMS2_k127_2376393_5 933262.AXAM01000019_gene1119 3.213e-46 173.0 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,42TC0@68525|delta/epsilon subdivisions,2WPYI@28221|Deltaproteobacteria,2MK6A@213118|Desulfobacterales 28221|Deltaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR CMS2_k127_2376393_9 439375.Oant_2962 4.616e-22 99.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,1J3V1@118882|Brucellaceae 28211|Alphaproteobacteria E Glutamine amidotransferase domain asnO - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS2_k127_2376393_11 408672.NBCG_05543 5.114e-13 78.0 COG0380@1|root,COG0561@1|root,COG0380@2|Bacteria,COG0561@2|Bacteria,2GMX7@201174|Actinobacteria,4DNDY@85009|Propionibacteriales 201174|Actinobacteria G Glycosyltransferase family 20 - - - - - - - - - - - - Glyco_transf_20,S6PP CMS2_k127_2376393_6 945713.IALB_0862 4.82e-34 147.0 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Alginate_exp,BBP2,MucBP,Porin_4,SLH CMS2_k127_2376393_2 1121439.dsat_1236 4.639e-105 352.0 COG0348@1|root,COG0348@2|Bacteria,1R4WT@1224|Proteobacteria,42NQI@68525|delta/epsilon subdivisions,2WKGR@28221|Deltaproteobacteria,2M7YW@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding - - - - - - - - - - - - Fer4,Fer4_5,Fer4_9 CMS2_k127_2376393_7 290397.Adeh_3190 1.408e-32 133.0 COG4309@1|root,COG4309@2|Bacteria,1P367@1224|Proteobacteria,42TEV@68525|delta/epsilon subdivisions 1224|Proteobacteria S Uncharacterized conserved protein (DUF2249) - - - - - - - - - - - - DUF1858,DUF2249 CMS2_k127_2376393_1 404589.Anae109_1669 8.352e-151 487.0 COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Hemerythrin HHE cation binding domain - - - ko:K09155 - - - - ko00000 - - - DUF1858,DUF438,Hemerythrin,PAS_10 CMS2_k127_2376393_8 1382356.JQMP01000001_gene797 2.089e-27 115.0 COG1959@1|root,COG1959@2|Bacteria 2|Bacteria K 2 iron, 2 sulfur cluster binding - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 CMS2_k127_2376393_10 443143.GM18_0922 1.779e-16 88.0 COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42X9Z@68525|delta/epsilon subdivisions,2WSPW@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Rieske 2Fe-2S cbcV - 1.10.9.1 ko:K02636 ko00195,ko01100,map00195,map01100 M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - iAF987.Gmet_1922 CytB6-F_Fe-S,Rieske CMS2_k127_2376393_3 880073.Calab_3613 1.448e-81 284.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944 - ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_B_N_2,Cytochrome_B CMS2_k127_2376393_0 290397.Adeh_1764 4.838e-210 665.0 COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto CMS2_k127_2376393_4 398767.Glov_1056 3.16e-81 276.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2WKKT@28221|Deltaproteobacteria,43VZF@69541|Desulfuromonadales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA NapA NarB subfamily - - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal CMS2_k127_2380148_31 386415.NT01CX_1052 2.635e-69 239.0 2B9ZZ@1|root,323DM@2|Bacteria,1V6N4@1239|Firmicutes,24JC8@186801|Clostridia,36RET@31979|Clostridiaceae 186801|Clostridia S COG NOG15344 non supervised orthologous group - - - - - - - - - - - - - CMS2_k127_2380148_53 1392489.JPOL01000002_gene322 5.843e-27 112.0 2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,1I02M@117743|Flavobacteriia,2XK75@283735|Leeuwenhoekiella 976|Bacteroidetes S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - CMS2_k127_2380148_60 449673.BACSTE_01504 0.00025 45.0 2AHEJ@1|root,317RR@2|Bacteria,4P93N@976|Bacteroidetes,2FZC5@200643|Bacteroidia 449673.BACSTE_01504|- - - - - - - - - - - - - - - - CMS2_k127_2380148_58 1340434.AXVA01000001_gene1114 2.436e-06 52.0 2EJBT@1|root,33D2X@2|Bacteria,1VKP4@1239|Firmicutes,4HRCQ@91061|Bacilli,1ZJ7K@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - CMS2_k127_2380148_59 1463857.JOFZ01000001_gene5873 0.0001157 51.0 COG1846@1|root,COG1846@2|Bacteria,2IQU8@201174|Actinobacteria 201174|Actinobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 CMS2_k127_2380148_15 264732.Moth_1517 6.07e-123 410.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 CMS2_k127_2380148_32 861299.J421_3205 8.653e-67 239.0 COG1159@1|root,COG1159@2|Bacteria,1ZUSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 CMS2_k127_2380148_56 1125863.JAFN01000001_gene531 1.319e-16 82.0 COG2835@1|root,COG2835@2|Bacteria,1Q1BG@1224|Proteobacteria,42WTN@68525|delta/epsilon subdivisions,2WSI9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p CMS2_k127_2380148_46 1379270.AUXF01000006_gene314 1.56e-43 171.0 COG1159@1|root,COG1159@2|Bacteria,1ZU0Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism - - - - - - - - - - - - - CMS2_k127_2380148_39 379066.GAU_1575 2.051e-53 198.0 2BXP0@1|root,34268@2|Bacteria,1ZTVK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_2380148_21 1379270.AUXF01000006_gene312 1.189e-95 323.0 COG2199@1|root,COG2199@2|Bacteria,1ZT1F@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF CMS2_k127_2380148_48 861299.J421_3210 7.985e-41 164.0 2F3JX@1|root,33WDB@2|Bacteria,1ZTZI@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - zinc_ribbon_4 CMS2_k127_2380148_12 861299.J421_3211 4.082e-128 419.0 COG1186@1|root,COG1186@2|Bacteria,1ZTE4@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 CMS2_k127_2380148_6 518766.Rmar_0302 7.587e-166 536.0 COG1190@1|root,COG1190@2|Bacteria,4NDZN@976|Bacteroidetes,1FISX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF4332,tRNA-synt_2,tRNA_anti-codon CMS2_k127_2380148_14 861299.J421_3213 4.025e-123 407.0 COG4591@1|root,COG4591@2|Bacteria,1ZT1N@142182|Gemmatimonadetes 142182|Gemmatimonadetes M MacB-like periplasmic core domain - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD CMS2_k127_2380148_29 861299.J421_3214 3.813e-77 272.0 COG1136@1|root,COG1136@2|Bacteria,1ZSNF@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Part of the ABC transporter complex LolCDE involved in the translocation of lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran CMS2_k127_2380148_41 1379270.AUXF01000006_gene306 6.734e-50 183.0 COG3880@1|root,COG3880@2|Bacteria,1ZTPQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S UvrB/uvrC motif - - - ko:K19411 - - - - ko00000 - - - UVR CMS2_k127_2380148_9 861299.J421_3216 3.428e-134 437.0 COG3869@1|root,COG3869@2|Bacteria,1ZT9I@142182|Gemmatimonadetes 142182|Gemmatimonadetes F ATP:guanido phosphotransferase, C-terminal catalytic domain - - 2.7.14.1 ko:K19405 - - R11090 RC00002,RC00203 ko00000,ko01000 - - - ATP-gua_Ptrans CMS2_k127_2380148_0 1345697.M493_00740 4.308e-306 958.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,4HACY@91061|Bacilli,1WEVP@129337|Geobacillus 91061|Bacilli O Belongs to the ClpA ClpB family clpC GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR CMS2_k127_2380148_2 861299.J421_3218 2.327e-213 689.0 COG4775@1|root,COG4775@2|Bacteria,1ZT6B@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA CMS2_k127_2380148_62 643867.Ftrac_1772 0.0009444 49.0 COG2825@1|root,COG2825@2|Bacteria,4NQHJ@976|Bacteroidetes,47QWE@768503|Cytophagia 976|Bacteroidetes M PFAM Outer membrane protein (OmpH-like) ompH - - ko:K06142 - - - - ko00000 - - - OmpH CMS2_k127_2380148_23 861299.J421_3220 2.376e-92 314.0 COG1044@1|root,COG1044@2|Bacteria,1ZSRF@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,LpxD CMS2_k127_2380148_7 379066.GAU_1588 5.335e-143 465.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,1ZT4Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes IM Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ - 3.5.1.108,4.2.1.59 ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 - - - FabA,LpxC CMS2_k127_2380148_25 1379270.AUXF01000006_gene299 1.785e-84 287.0 COG1043@1|root,COG1043@2|Bacteria,1ZT7T@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep CMS2_k127_2380148_26 861299.J421_3224 1.023e-82 287.0 COG0763@1|root,COG0763@2|Bacteria,1ZTAD@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB CMS2_k127_2380148_50 861299.J421_3225 7.806e-39 152.0 COG2121@1|root,COG2121@2|Bacteria,1ZTU5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF374) - - - ko:K09778 - - - - ko00000 - - - DUF374 CMS2_k127_2380148_37 861299.J421_3226 4.643e-56 210.0 COG1663@1|root,COG1663@2|Bacteria,1ZTIE@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK CMS2_k127_2380148_4 861299.J421_3227 1.818e-198 627.0 COG0334@1|root,COG0334@2|Bacteria,1ZSQB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS2_k127_2380148_51 861299.J421_3228 1.865e-30 128.0 COG1576@1|root,COG1576@2|Bacteria,1ZTQJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase CMS2_k127_2380148_40 880073.Calab_3787 2.17e-51 190.0 COG0500@1|root,COG0500@2|Bacteria 2|Bacteria Q methyltransferase activity yccK - - - - - - - - - - - Methyltransf_23,Methyltransf_25,Methyltransf_31,TehB CMS2_k127_2380148_35 555088.DealDRAFT_1413 2.384e-60 229.0 COG4365@1|root,COG4365@2|Bacteria,1TQ2P@1239|Firmicutes,24DMW@186801|Clostridia 186801|Clostridia S Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH bshC - - ko:K22136 - - - - ko00000 - - - BshC CMS2_k127_2380148_19 379066.GAU_1597 1.079e-106 364.0 COG0728@1|root,COG0728@2|Bacteria,1ZTCM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN CMS2_k127_2380148_3 1379270.AUXF01000006_gene290 9.586e-212 673.0 COG0322@1|root,COG0322@2|Bacteria,1ZSXE@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N CMS2_k127_2380148_17 861299.J421_3232 9.105e-116 384.0 COG0498@1|root,COG0498@2|Bacteria,1ZT17@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Pyridoxal-phosphate dependent enzyme - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_2380148_28 861299.J421_3233 4.19e-79 278.0 COG1641@1|root,COG1641@2|Bacteria 2|Bacteria H Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes larC - 4.99.1.12 ko:K06898,ko:K09121 - - - - ko00000,ko01000 - - - DUF111 CMS2_k127_2380148_52 1379270.AUXF01000006_gene288 5.403e-29 132.0 COG4783@1|root,COG4783@2|Bacteria,1ZT4T@142182|Gemmatimonadetes 2|Bacteria S chaperone-mediated protein folding - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PQQ_2,TPR_8,UnbV_ASPIC,VCBS CMS2_k127_2380148_61 1461580.CCAS010000015_gene1842 0.0004455 46.0 2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - CMS2_k127_2380148_10 1379270.AUXF01000006_gene287 9.515e-132 432.0 COG1625@1|root,COG1625@2|Bacteria,1ZSQ7@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF512) - - - - - - - - - - - - DUF512 CMS2_k127_2380148_13 562970.Btus_1769 5.328e-127 421.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,278SV@186823|Alicyclobacillaceae 91061|Bacilli S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 CMS2_k127_2380148_49 1384056.N787_03750 1.493e-40 158.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1X68Z@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf CMS2_k127_2380148_20 861299.J421_3237 7.497e-98 330.0 COG0240@1|root,COG0240@2|Bacteria,1ZTFK@142182|Gemmatimonadetes 142182|Gemmatimonadetes I NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N CMS2_k127_2380148_47 379066.GAU_1604 7.372e-43 160.0 COG0789@1|root,COG0789@2|Bacteria,1ZTSI@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 CMS2_k127_2380148_24 379066.GAU_1605 4.724e-89 300.0 COG0496@1|root,COG0496@2|Bacteria,1ZT6W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE CMS2_k127_2380148_34 861299.J421_3240 3.598e-61 221.0 COG2518@1|root,COG2518@2|Bacteria,1ZTED@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS2_k127_2380148_33 404380.Gbem_0611 1.029e-61 219.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2WNP9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc CMS2_k127_2380148_55 1121861.KB899912_gene980 8.14e-19 91.0 COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,2JTTR@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the acylphosphatase family acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase CMS2_k127_2380148_57 290318.Cvib_0536 3.475e-07 60.0 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization - - - - - - - - - - - - TPR_16,TPR_21,TPR_6 CMS2_k127_2380148_38 379066.GAU_1611 4.696e-56 208.0 COG0253@1|root,COG0253@2|Bacteria,1ZU42@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan - - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase CMS2_k127_2380148_18 1379270.AUXF01000006_gene276 6.689e-115 374.0 COG0463@1|root,COG0463@2|Bacteria,1ZT31@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyltransferase like family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 CMS2_k127_2380148_8 1379270.AUXF01000004_gene2892 6.238e-141 477.0 COG4485@1|root,COG4485@2|Bacteria 2|Bacteria M Bacterial membrane protein, YfhO - - - - - - - - - - - - YfhO CMS2_k127_2380148_45 1379270.AUXF01000006_gene275 3.527e-44 173.0 COG0392@1|root,COG0392@2|Bacteria,1ZTX4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS2_k127_2380148_36 379066.GAU_1615 1.492e-58 218.0 COG0438@1|root,COG0438@2|Bacteria,1ZSTJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS2_k127_2380148_22 379066.GAU_1616 3.341e-94 321.0 COG0463@1|root,COG0463@2|Bacteria,1ZTEI@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 CMS2_k127_2380148_5 861299.J421_3250 6.198e-192 611.0 COG1508@1|root,COG1508@2|Bacteria,1ZT13@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-54 factor, Activator interacting domain (AID) - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD CMS2_k127_2380148_11 861299.J421_3251 6.639e-129 424.0 COG1137@1|root,COG1137@2|Bacteria,1ZT4S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran CMS2_k127_2380148_44 861299.J421_3252 1.528e-44 178.0 2F01D@1|root,33T57@2|Bacteria,1ZTGK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_2380148_54 861299.J421_3253 6.913e-23 106.0 2DWX3@1|root,342B9@2|Bacteria,1ZTXN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lipopolysaccharide-assembly, LptC-related - - - - - - - - - - - - LptC CMS2_k127_2380148_42 1379270.AUXF01000006_gene267 7.206e-49 183.0 COG1778@1|root,COG1778@2|Bacteria,1ZTTG@142182|Gemmatimonadetes 142182|Gemmatimonadetes S haloacid dehalogenase-like hydrolase - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 CMS2_k127_2380148_27 643562.Daes_1470 2.757e-79 276.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2M90H@213115|Desulfovibrionales 28221|Deltaproteobacteria M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 CMS2_k127_2380148_1 861299.J421_3257 2.481e-251 785.0 COG0504@1|root,COG0504@2|Bacteria,1ZT0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase CMS2_k127_2380148_43 1379270.AUXF01000006_gene264 7.137e-47 178.0 COG1212@1|root,COG1212@2|Bacteria,1ZSRD@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 CMS2_k127_2380148_30 224324.aq_549 3.705e-74 254.0 COG0512@1|root,COG0512@2|Bacteria,2G3WI@200783|Aquificae 200783|Aquificae EH TIGRFAM glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase CMS2_k127_2380148_16 861299.J421_3262 4.855e-120 393.0 COG4974@1|root,COG4974@2|Bacteria,1ZTAH@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Phage integrase, N-terminal SAM-like domain xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase CMS2_k127_2397435_25 979556.MTES_2317 1.289e-06 52.0 COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,4FQ2D@85023|Microbacteriaceae 201174|Actinobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_17 CMS2_k127_2397435_27 234267.Acid_3946 0.0008767 48.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4440,SnoaL_3 CMS2_k127_2397435_26 290397.Adeh_2288 0.0008576 48.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - 5.3.3.1 ko:K01822 ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120 M00107,M00110 R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955 RC00146,RC00762 ko00000,ko00001,ko00002,ko01000 - - - DUF4440,SnoaL_2,SnoaL_3 CMS2_k127_2397435_18 1379270.AUXF01000001_gene2747 3.591e-28 125.0 COG1196@1|root,COG1196@2|Bacteria,1ZU2U@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - CMS2_k127_2397435_8 709986.Deima_0373 1.753e-70 246.0 COG1794@1|root,COG1794@2|Bacteria 2|Bacteria M racemase activity, acting on amino acids and derivatives - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race CMS2_k127_2397435_20 1227488.C477_20865 4.596e-27 128.0 COG0642@1|root,arCOG02330@1|root,arCOG02330@2157|Archaea,arCOG02358@2157|Archaea,2Y7KE@28890|Euryarchaeota 28890|Euryarchaeota T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4 CMS2_k127_2397435_5 379066.GAU_1692 1.058e-135 447.0 COG0260@1|root,COG0260@2|Bacteria,1ZSPX@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N CMS2_k127_2397435_23 1379270.AUXF01000006_gene200 3.74e-16 93.0 COG4206@1|root,COG4206@2|Bacteria,1ZT1E@142182|Gemmatimonadetes 142182|Gemmatimonadetes H TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug CMS2_k127_2397435_10 379066.GAU_1690 5.505e-64 230.0 COG1561@1|root,COG1561@2|Bacteria,1ZT99@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N CMS2_k127_2397435_12 861299.J421_3321 6.251e-51 190.0 COG0194@1|root,COG0194@2|Bacteria,1ZTV7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin CMS2_k127_2397435_22 1379270.AUXF01000006_gene203 2.219e-19 89.0 28VAR@1|root,2ZHDJ@2|Bacteria,1ZU25@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - - - - - - - - - - - RNA_pol_Rpb6 CMS2_k127_2397435_6 861299.J421_3319 2.492e-118 395.0 COG0452@1|root,COG0452@2|Bacteria,1ZV19@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein CMS2_k127_2397435_9 861299.J421_3318 2.026e-68 243.0 COG1573@1|root,COG1573@2|Bacteria,1ZTG5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG CMS2_k127_2397435_1 1379270.AUXF01000006_gene205 6.005e-165 531.0 COG0305@1|root,COG0305@2|Bacteria,1ZSMZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C CMS2_k127_2397435_0 861299.J421_3316 2.439e-167 539.0 COG1066@1|root,COG1066@2|Bacteria,1ZSYF@142182|Gemmatimonadetes 142182|Gemmatimonadetes O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - ATPase CMS2_k127_2397435_14 861299.J421_3315 1.888e-44 171.0 COG1211@1|root,COG1211@2|Bacteria,1ZSTV@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD CMS2_k127_2397435_11 861299.J421_3314 6.676e-54 196.0 COG0009@1|root,COG0009@2|Bacteria,1ZT3D@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Telomere recombination - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC CMS2_k127_2397435_17 861299.J421_3313 2.211e-40 155.0 COG0394@1|root,COG0394@2|Bacteria,1ZTSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Low molecular weight phosphatase family - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc CMS2_k127_2397435_15 861299.J421_3312 1.848e-43 169.0 COG0169@1|root,COG0169@2|Bacteria,1ZTVG@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_dh_N CMS2_k127_2397435_19 748247.AZKH_0995 5.154e-28 125.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria,2KWAY@206389|Rhodocyclales 206389|Rhodocyclales S Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran CMS2_k127_2397435_4 861299.J421_3310 1.396e-138 448.0 COG0057@1|root,COG0057@2|Bacteria,1ZSTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N CMS2_k127_2397435_3 861299.J421_3309 8.994e-145 470.0 COG0126@1|root,COG0126@2|Bacteria,1ZT1B@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK CMS2_k127_2397435_7 861299.J421_3308 7.435e-76 263.0 COG0149@1|root,COG0149@2|Bacteria,1ZSYN@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM CMS2_k127_2397435_21 379066.GAU_1676 5.391e-22 100.0 COG1314@1|root,COG1314@2|Bacteria,1ZTZS@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Preprotein translocase SecG subunit - - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG CMS2_k127_2397435_2 861299.J421_3306 6.548e-146 470.0 COG0505@1|root,COG0505@2|Bacteria,1ZT0T@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Carbamoyl-phosphate synthase small chain, CPSase domain carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase CMS2_k127_2397435_16 1379270.AUXF01000006_gene217 3.701e-42 157.0 COG0776@1|root,COG0776@2|Bacteria,1ZTTN@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions - - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS2_k127_2446291_0 234267.Acid_0751 7.122e-209 679.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_2446291_2 1267535.KB906767_gene3833 1.308e-34 136.0 COG1695@1|root,COG1695@2|Bacteria,3Y4XK@57723|Acidobacteria,2JJR3@204432|Acidobacteriia 2|Bacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_2446291_1 1183438.GKIL_4354 8.34e-155 521.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_2446291_3 234267.Acid_4839 1.788e-18 89.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_2456783_2 1268237.G114_10895 8.372e-49 175.0 2DWY1@1|root,342G1@2|Bacteria,1N2NN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_2456783_0 429009.Adeg_0748 2.04e-124 406.0 COG0702@1|root,COG0702@2|Bacteria 2|Bacteria GM epimerase - - - - - - - - - - - - NAD_binding_10,NmrA CMS2_k127_2456783_4 1379270.AUXF01000002_gene1589 2.753e-23 115.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_2456783_5 1047013.AQSP01000142_gene124 4.366e-12 79.0 COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria 2|Bacteria O NHL repeat - - - - - - - - - - - - DUF5128,NHL,TolB_like CMS2_k127_2456783_1 861299.J421_6034 3.924e-70 259.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS2_k127_2456783_3 1379270.AUXF01000002_gene1290 2.006e-28 132.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_2462124_2 861299.J421_2629 3.657e-125 404.0 COG0055@1|root,COG0055@2|Bacteria,1ZSNP@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N CMS2_k127_2462124_3 1379270.AUXF01000004_gene3173 5.218e-107 354.0 COG0224@1|root,COG0224@2|Bacteria,1ZSZR@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt CMS2_k127_2462124_0 861299.J421_2627 4.402e-235 736.0 COG0056@1|root,COG0056@2|Bacteria,1ZSNY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N CMS2_k127_2462124_8 1379270.AUXF01000004_gene3175 6.458e-43 167.0 COG2207@1|root,COG2207@2|Bacteria,1ZUCN@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 CMS2_k127_2462124_7 861299.J421_2626 2.885e-44 167.0 COG1051@1|root,COG1051@2|Bacteria,1ZTP5@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NUDIX domain - - - - - - - - - - - - NUDIX CMS2_k127_2462124_6 1379270.AUXF01000007_gene1059 5.601e-67 240.0 COG1463@1|root,COG1463@2|Bacteria,1ZUJC@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS2_k127_2462124_4 861299.J421_2625 1.107e-101 339.0 COG1127@1|root,COG1127@2|Bacteria,1ZT5N@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran CMS2_k127_2462124_5 379066.GAU_3855 7.358e-76 259.0 COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS2_k127_2462124_1 379066.GAU_0710 1.079e-146 469.0 COG0568@1|root,COG0568@2|Bacteria,1ZTCX@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 CMS2_k127_2462124_11 225937.HP15_1506 1.271e-05 48.0 COG1376@1|root,COG1376@2|Bacteria,1RA7Q@1224|Proteobacteria,1RSIE@1236|Gammaproteobacteria,46AD9@72275|Alteromonadaceae 1236|Gammaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD_2 CMS2_k127_2462124_9 202952.BBLI01000003_gene293 2.819e-07 55.0 2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria,3NQGN@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2462124_14 436229.JOEH01000009_gene4564 0.0005723 46.0 COG1609@1|root,COG1609@2|Bacteria,2GSWK@201174|Actinobacteria,2NJKA@228398|Streptacidiphilus 201174|Actinobacteria K Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - LacI,Phage_int_SAM_3,Phage_integrase CMS2_k127_2462124_10 1150469.RSPPHO_02782 8.019e-07 51.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process - - - ko:K10297 - - - - ko00000,ko04121 - - - Beta_helix,SLH,TIR_2 CMS2_k127_2462124_13 944481.JAFP01000001_gene95 6.39e-05 48.0 COG1598@1|root,COG1598@2|Bacteria,1QSXW@1224|Proteobacteria,42X4E@68525|delta/epsilon subdivisions 1224|Proteobacteria S HicB_like antitoxin of bacterial toxin-antitoxin system - - - - - - - - - - - - HicB_lk_antitox CMS2_k127_2472460_3 158190.SpiGrapes_2246 3.781e-05 51.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process - - - - - - - - - - - - MatE,Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C CMS2_k127_2472460_2 1089550.ATTH01000001_gene260 4.207e-07 62.0 COG0438@1|root,COG0438@2|Bacteria,4PF1F@976|Bacteroidetes,1FJZT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - - CMS2_k127_2472460_0 378806.STAUR_1596 2.813e-54 209.0 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,42NVY@68525|delta/epsilon subdivisions,2WKWM@28221|Deltaproteobacteria,2YU8T@29|Myxococcales 28221|Deltaproteobacteria M Glycosyl transferase family 4 - - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 CMS2_k127_2472460_1 596152.DesU5LDRAFT_0725 9.52e-22 102.0 COG0438@1|root,COG0438@2|Bacteria,1MVB4@1224|Proteobacteria,42TB1@68525|delta/epsilon subdivisions,2WRAQ@28221|Deltaproteobacteria,2M9W4@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.348 ko:K12995 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS2_k127_2543587_25 1120949.KB903357_gene4933 0.0003876 53.0 COG4447@1|root,COG4447@2|Bacteria,2IT8P@201174|Actinobacteria 201174|Actinobacteria M phospholipase C - - - - - - - - - - - - - CMS2_k127_2543587_0 1123234.AUKI01000019_gene551 3.361e-93 337.0 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - ANAPC3,Guanylate_cyc,HTH_18,TPR_8 CMS2_k127_2543587_3 861299.J421_1863 2.516e-69 266.0 COG0515@1|root,COG3629@1|root,COG0515@2|Bacteria,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS2_k127_2543587_19 1121859.KB890756_gene1367 5.125e-08 57.0 COG0606@1|root,COG0606@2|Bacteria,4NE0G@976|Bacteroidetes,47MUV@768503|Cytophagia 976|Bacteroidetes O magnesium chelatase comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C CMS2_k127_2543587_9 1379270.AUXF01000002_gene1589 7.527e-28 118.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_2543587_11 314285.KT71_04550 7.915e-24 111.0 2EMUX@1|root,33FH7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_2543587_23 1267534.KB906756_gene486 8.304e-06 54.0 COG4319@1|root,COG4319@2|Bacteria,3Y90I@57723|Acidobacteria 57723|Acidobacteria S SnoaL-like domain - - - - - - - - - - - - - CMS2_k127_2543587_13 1120951.AUBG01000006_gene521 5.068e-18 93.0 2E3AK@1|root,32YA3@2|Bacteria,4NUYM@976|Bacteroidetes,1I52E@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_2543587_24 1267534.KB906756_gene153 0.0001824 51.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Beta-lactamase,DUF4440,SnoaL_2,SnoaL_3 CMS2_k127_2543587_21 566466.NOR53_903 1.204e-06 51.0 2EMUX@1|root,33FH7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_2543587_12 869210.Marky_1921 6.961e-21 97.0 COG0517@1|root,COG5485@1|root,COG0517@2|Bacteria,COG5485@2|Bacteria,1WK3F@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS CMS2_k127_2543587_22 391603.FBALC1_13067 2.674e-06 58.0 2E3AK@1|root,32YA3@2|Bacteria,4NUYM@976|Bacteroidetes,1IIAT@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_2543587_2 469383.Cwoe_4585 1.67e-75 262.0 COG0500@1|root,COG2226@2|Bacteria,2GM0Y@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 CMS2_k127_2543587_17 1079460.ATTQ01000023_gene270 3.915e-12 73.0 COG4319@1|root,COG4319@2|Bacteria,1RF3Q@1224|Proteobacteria,2U78H@28211|Alphaproteobacteria,4BJV7@82115|Rhizobiaceae 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS2_k127_2543587_14 448385.sce8386 1.335e-17 91.0 COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,43737@68525|delta/epsilon subdivisions,2X934@28221|Deltaproteobacteria,2Z1NS@29|Myxococcales 28221|Deltaproteobacteria C Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity - - - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 CMS2_k127_2543587_15 398767.Glov_0194 7.587e-15 83.0 COG3620@1|root,COG3620@2|Bacteria 2|Bacteria K sequence-specific DNA binding cbs GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.5.1.47,4.2.1.22 ko:K01697,ko:K01738 ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00035,M00338 R00891,R00897,R01290,R03601,R04859,R04942 RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP CMS2_k127_2543587_6 518766.Rmar_1523 4.823e-46 172.0 COG0606@1|root,COG0606@2|Bacteria,4NE0G@976|Bacteroidetes,1FITT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O Magnesium chelatase, subunit ChlI C-terminal comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C CMS2_k127_2543587_18 187303.BN69_3199 3.986e-12 70.0 COG4691@1|root,COG4691@2|Bacteria 2|Bacteria S Plasmid stability protein - - - ko:K21495 - - - - ko00000,ko02048 - - - Arc CMS2_k127_2543587_10 663932.KB902575_gene1191 5.73e-25 108.0 COG4113@1|root,COG4113@2|Bacteria 2|Bacteria S Toxic component of a toxin-antitoxin (TA) module. An RNase vapC - - - - - - - - - - - PIN CMS2_k127_2543587_8 468059.AUHA01000002_gene718 1.95e-28 126.0 COG0793@1|root,COG0793@2|Bacteria,4NEF4@976|Bacteroidetes,1IQVH@117747|Sphingobacteriia 976|Bacteroidetes M PDZ DHR GLGF domain protein - - - - - - - - - - - - Asp_protease_2,PDZ,PDZ_2 CMS2_k127_2543587_16 1121899.Q764_12960 8.81e-15 77.0 COG0606@1|root,COG0606@2|Bacteria,4NE0G@976|Bacteroidetes,1HXWB@117743|Flavobacteriia,2NSWB@237|Flavobacterium 976|Bacteroidetes O magnesium chelatase comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C CMS2_k127_2543587_4 696281.Desru_3126 1.148e-67 247.0 COG2199@1|root,COG3706@2|Bacteria,1V469@1239|Firmicutes,25BDA@186801|Clostridia,2625Y@186807|Peptococcaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GGDEF,PilJ CMS2_k127_2543587_1 1125863.JAFN01000001_gene1414 2.28e-78 270.0 COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM asparagine synthase - - - ko:K06864 - - - - ko00000 - - - Asn_synthase,NAD_synthase,QueC CMS2_k127_2543587_7 1379698.RBG1_1C00001G1887 1.287e-30 127.0 COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria 2|Bacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase CMS2_k127_2543587_20 861299.J421_2916 7.749e-08 61.0 28R18@1|root,2ZDFV@2|Bacteria,1ZU2V@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_2543587_5 861299.J421_2921 1.115e-52 192.0 COG0681@1|root,COG0681@2|Bacteria,1ZTQ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 CMS2_k127_2592004_4 1379270.AUXF01000004_gene3324 4.008e-114 376.0 COG4584@1|root,COG4584@2|Bacteria,1ZV8R@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Integrase core domain - - - - - - - - - - - - rve CMS2_k127_2592004_3 1379270.AUXF01000004_gene3323 1.527e-117 384.0 COG1484@1|root,COG1484@2|Bacteria,1ZV5D@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bacterial dnaA protein - - - - - - - - - - - - IstB_IS21 CMS2_k127_2592004_7 639030.JHVA01000001_gene2358 2.444e-24 106.0 COG1695@1|root,COG1695@2|Bacteria,3Y4XD@57723|Acidobacteria,2JJIX@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_2592004_1 1183438.GKIL_4354 7.784e-138 472.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_2592004_9 1128421.JAGA01000003_gene3339 5.42e-17 81.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - ko:K03466,ko:K06915 - - - - ko00000,ko03036 3.A.12 - - DUF853,DUF87 CMS2_k127_2592004_8 861299.J421_2152 3.607e-19 101.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS2_k127_2592004_11 485913.Krac_0366 5.076e-06 51.0 COG3316@1|root,COG3316@2|Bacteria,2G9P3@200795|Chloroflexi 200795|Chloroflexi L COGs COG3316 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS240 CMS2_k127_2592004_2 1123277.KB893181_gene2301 4.806e-128 416.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity - - 3.1.1.23 ko:K01054 ko00561,ko01100,ko04714,ko04723,ko04923,map00561,map01100,map04714,map04723,map04923 M00098 R01351 RC00020,RC00041 ko00000,ko00001,ko00002,ko01000,ko01002 - - - Hydrolase_4 CMS2_k127_2592004_10 1121875.KB907553_gene24 1.982e-08 61.0 COG0412@1|root,COG1262@1|root,COG2114@1|root,COG0412@2|Bacteria,COG1262@2|Bacteria,COG2114@2|Bacteria,4PPKM@976|Bacteroidetes 976|Bacteroidetes T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc CMS2_k127_2592004_6 251221.35211248 8.199e-25 108.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_2592004_0 1183438.GKIL_4354 1.785e-157 531.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_2592004_5 203275.BFO_0222 1.028e-98 337.0 COG0793@1|root,COG0793@2|Bacteria,4NEFX@976|Bacteroidetes,2FU5X@200643|Bacteroidia,22YP3@171551|Porphyromonadaceae 976|Bacteroidetes M Peptidase family S41 - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S41,Tricorn_C1 CMS2_k127_259664_13 1449126.JQKL01000050_gene2673 4.67e-15 74.0 COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,267PG@186813|unclassified Clostridiales 186801|Clostridia J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 CMS2_k127_259664_11 861299.J421_2760 7.423e-21 92.0 COG0267@1|root,COG0267@2|Bacteria,1ZV8A@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L33 - - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 CMS2_k127_259664_14 215803.DB30_0640 3.884e-06 52.0 2A4V8@1|root,30TGU@2|Bacteria,1Q3TG@1224|Proteobacteria,439MK@68525|delta/epsilon subdivisions,2X4YP@28221|Deltaproteobacteria,2YZUX@29|Myxococcales 28221|Deltaproteobacteria U SecE/Sec61-gamma subunits of protein translocation complex - - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE CMS2_k127_259664_5 379066.GAU_0850 2.149e-76 261.0 COG0250@1|root,COG0250@2|Bacteria,1ZSS2@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - NusG CMS2_k127_259664_8 1394178.AWOO02000003_gene2790 1.126e-61 215.0 COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4EJ4N@85012|Streptosporangiales 201174|Actinobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N CMS2_k127_259664_4 861299.J421_2764 1.243e-96 322.0 COG0081@1|root,COG0081@2|Bacteria,1ZSS7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 CMS2_k127_259664_9 861299.J421_2765 1.606e-43 166.0 COG0244@1|root,COG0244@2|Bacteria,1ZTQI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 CMS2_k127_259664_10 861299.J421_2766 1.823e-43 162.0 COG0222@1|root,COG0222@2|Bacteria,1ZTTC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N CMS2_k127_259664_1 290397.Adeh_1592 0.0 1282.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 CMS2_k127_259664_0 861299.J421_2768 0.0 2216.0 COG0086@1|root,COG0086@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 CMS2_k127_259664_3 1237149.C900_03194 1.665e-122 404.0 COG0520@1|root,COG0520@2|Bacteria,4NJEQ@976|Bacteroidetes,47NQ3@768503|Cytophagia 976|Bacteroidetes E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS2_k127_259664_7 880073.Calab_2121 4.136e-65 223.0 COG0048@1|root,COG0048@2|Bacteria,2NPA7@2323|unclassified Bacteria 2|Bacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 CMS2_k127_259664_6 861299.J421_2770 4.719e-70 242.0 COG0049@1|root,COG0049@2|Bacteria,1ZSQZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 CMS2_k127_259664_2 1122134.KB893651_gene1774 1.079e-283 890.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XH4H@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 CMS2_k127_259664_12 706434.HMPREF9429_00740 3.397e-15 75.0 COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,4H22P@909932|Negativicutes 909932|Negativicutes J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 CMS2_k127_260461_47 316067.Geob_2508 9.273e-73 253.0 COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C CMS2_k127_260461_2 861299.J421_4088 2.684e-222 718.0 COG3408@1|root,COG3408@2|Bacteria 2|Bacteria G Glycogen debranching enzyme - - - - - - - - - - - - Bac_rhamnosid6H,GDE_C,SLH CMS2_k127_260461_1 1047013.AQSP01000106_gene1761 8.798e-229 720.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - PA,Peptidase_M28 CMS2_k127_260461_60 1123368.AUIS01000018_gene733 3.741e-59 214.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019538,GO:0020037,GO:0030091,GO:0031224,GO:0031226,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 - ko:K17247 - - - - ko00000 - - - Ferric_reduct CMS2_k127_260461_14 243365.CV_0789 4.953e-129 418.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2VH08@28216|Betaproteobacteria,2KPV7@206351|Neisseriales 206351|Neisseriales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb CMS2_k127_260461_33 1122963.AUHB01000003_gene4023 1.249e-95 327.0 COG0153@1|root,COG0153@2|Bacteria,1MVQD@1224|Proteobacteria,2U2RP@28211|Alphaproteobacteria,36ZV4@31993|Methylocystaceae 28211|Alphaproteobacteria G Galactokinase galactose-binding signature galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg CMS2_k127_260461_95 411901.BACCAC_02166 6.806e-07 59.0 COG1629@1|root,COG4771@2|Bacteria,4NE4M@976|Bacteroidetes,2FNUY@200643|Bacteroidia,4AP6U@815|Bacteroidaceae 976|Bacteroidetes P Psort location OuterMembrane, score - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_260461_8 1379270.AUXF01000005_gene461 1.25e-155 539.0 COG5000@1|root,COG5000@2|Bacteria,1ZSZU@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c CMS2_k127_260461_50 861299.J421_2906 2.014e-68 246.0 COG1402@1|root,COG1402@2|Bacteria 2|Bacteria I creatininase - - 3.5.2.10 ko:K01470,ko:K22232 ko00330,ko00562,map00330,map00562 - R01884,R11771 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS2_k127_260461_91 861299.J421_2905 3.304e-12 75.0 2FH8I@1|root,3492W@2|Bacteria,1ZTXF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_260461_44 861299.J421_2904 3.095e-77 277.0 COG1538@1|root,COG1538@2|Bacteria,1ZSMB@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP CMS2_k127_260461_27 1379270.AUXF01000005_gene458 4.778e-103 349.0 COG0845@1|root,COG0845@2|Bacteria,1ZSX4@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 CMS2_k127_260461_29 861299.J421_2902 6.605e-100 332.0 COG1136@1|root,COG1136@2|Bacteria,1ZSKH@142182|Gemmatimonadetes 142182|Gemmatimonadetes V membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_260461_23 379066.GAU_1145 8.381e-118 392.0 COG0577@1|root,COG0577@2|Bacteria,1ZUU2@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_260461_28 861299.J421_2900 3.188e-102 349.0 COG0577@1|root,COG0577@2|Bacteria,1ZUN6@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_260461_9 861299.J421_1415 2.918e-153 494.0 COG0577@1|root,COG0577@2|Bacteria,1ZUG3@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_260461_13 1379270.AUXF01000005_gene449 1.787e-130 428.0 COG0577@1|root,COG0577@2|Bacteria,1ZUCK@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_260461_38 861299.J421_2896 7.922e-88 297.0 COG2120@1|root,COG2120@2|Bacteria,1ZTDK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S GlcNAc-PI de-N-acetylase - - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L CMS2_k127_260461_36 861299.J421_2892 1.697e-93 320.0 COG1104@1|root,COG1104@2|Bacteria,1ZSXD@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class-V - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 CMS2_k127_260461_16 861299.J421_2891 9.293e-125 410.0 COG0482@1|root,COG0482@2|Bacteria,1ZST7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans CMS2_k127_260461_64 83219.PM02_16895 2.504e-56 205.0 COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,3ZUXT@60136|Sulfitobacter 28211|Alphaproteobacteria O OsmC-like protein MA20_16590 - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4,OsmC CMS2_k127_260461_75 1128421.JAGA01000002_gene1615 3.107e-31 128.0 COG1765@1|root,COG1765@2|Bacteria,2NPY5@2323|unclassified Bacteria 2|Bacteria O OsmC-like protein MA20_16590 - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4,OsmC CMS2_k127_260461_83 366602.Caul_0664 4.105e-22 101.0 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2UDEK@28211|Alphaproteobacteria,2KGZA@204458|Caulobacterales 204458|Caulobacterales S PFAM Membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 CMS2_k127_260461_66 706587.Desti_1672 1.814e-43 162.0 COG0432@1|root,COG0432@2|Bacteria,1N5SN@1224|Proteobacteria,42SJC@68525|delta/epsilon subdivisions,2WP9F@28221|Deltaproteobacteria,2MRXI@213462|Syntrophobacterales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 CMS2_k127_260461_21 379066.GAU_1124 5.417e-119 396.0 COG0484@1|root,COG0484@2|Bacteria,1ZT5T@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG CMS2_k127_260461_76 379066.GAU_1123 4.201e-31 130.0 COG0576@1|root,COG0576@2|Bacteria,1ZTSJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE CMS2_k127_260461_26 379066.GAU_1122 5.183e-105 356.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1ZSS9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Competence-damaged protein - - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth CMS2_k127_260461_68 1379270.AUXF01000005_gene391 5.469e-42 162.0 COG0558@1|root,COG0558@2|Bacteria,1ZSXG@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf CMS2_k127_260461_22 379066.GAU_1116 4.132e-118 383.0 COG1100@1|root,COG1100@2|Bacteria,1ZSQI@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ADP-ribosylation factor family - - - ko:K06883 - - - - ko00000 - - - Arf CMS2_k127_260461_63 379066.GAU_1115 4.931e-58 205.0 COG2018@1|root,COG2018@2|Bacteria,1ZTK7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Roadblock/LC7 domain - - - - - - - - - - - - Robl_LC7 CMS2_k127_260461_87 1379270.AUXF01000005_gene388 2.768e-16 83.0 29142@1|root,2ZNRG@2|Bacteria,1ZV6W@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_260461_45 861299.J421_2883 3.983e-75 259.0 COG0353@1|root,COG0353@2|Bacteria,1ZTJX@142182|Gemmatimonadetes 142182|Gemmatimonadetes L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 CMS2_k127_260461_77 861299.J421_2882 6.944e-31 124.0 COG0718@1|root,COG0718@2|Bacteria,1ZU1F@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd CMS2_k127_260461_10 379066.GAU_1112 1.017e-137 456.0 COG2812@1|root,COG2812@2|Bacteria,1ZTFV@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 CMS2_k127_260461_20 1125863.JAFN01000001_gene2804 4.821e-119 399.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH CMS2_k127_260461_34 1125863.JAFN01000001_gene2805 3.194e-95 328.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM TrkA-N domain protein trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N CMS2_k127_260461_35 379066.GAU_1110 5.301e-94 319.0 COG2008@1|root,COG2008@2|Bacteria,1ZT2G@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS2_k127_260461_84 379066.GAU_1109 1.106e-19 99.0 COG1295@1|root,COG1295@2|Bacteria,1ZTHX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB CMS2_k127_260461_88 379066.GAU_1108 3.757e-16 84.0 COG4980@1|root,COG4980@2|Bacteria,1ZU46@142182|Gemmatimonadetes 142182|Gemmatimonadetes S YtxH-like protein - - - - - - - - - - - - YtxH CMS2_k127_260461_39 861299.J421_2872 2.699e-87 296.0 COG1235@1|root,COG1235@2|Bacteria,1ZT49@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - 3.1.4.55 ko:K06167 ko00440,map00440 - R10205 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 CMS2_k127_260461_17 379066.GAU_1104 7.455e-124 416.0 COG0469@1|root,COG0469@2|Bacteria,1ZSMD@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Pyruvate kinase, barrel domain - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C CMS2_k127_260461_51 187272.Mlg_2040 4.479e-68 240.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria,1WYE1@135613|Chromatiales 135613|Chromatiales K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 CMS2_k127_260461_4 861299.J421_1297 1.286e-183 584.0 COG0821@1|root,COG0821@2|Bacteria,1ZST3@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE CMS2_k127_260461_12 713586.KB900536_gene1317 4.417e-132 430.0 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1WZYG@135613|Chromatiales 135613|Chromatiales G Fructose-bisphosphate aldolase class-I - - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic CMS2_k127_260461_0 861299.J421_2847 0.0 1161.0 COG0209@1|root,COG0209@2|Bacteria,1ZSU9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN CMS2_k127_260461_58 886293.Sinac_5721 1.93e-61 216.0 COG0663@1|root,COG0663@2|Bacteria,2IZP3@203682|Planctomycetes 203682|Planctomycetes S isoleucine patch - - - - - - - - - - - - Hexapep CMS2_k127_260461_49 861299.J421_2823 6.778e-69 258.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFI@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_260461_15 861299.J421_2845 9.866e-129 446.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSWP@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_260461_30 379066.GAU_0939 1.226e-99 349.0 COG0860@1|root,COG0860@2|Bacteria,1ZT6J@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 CMS2_k127_260461_79 502025.Hoch_4617 2.169e-29 130.0 COG1716@1|root,COG1716@2|Bacteria,1Q2GC@1224|Proteobacteria,4382T@68525|delta/epsilon subdivisions,2X0C6@28221|Deltaproteobacteria,2YVG7@29|Myxococcales 28221|Deltaproteobacteria T Forkhead associated domain - - - - - - - - - - - - FHA CMS2_k127_260461_32 1379270.AUXF01000007_gene1075 2.532e-96 336.0 COG0515@1|root,COG3170@1|root,COG0515@2|Bacteria,COG3170@2|Bacteria,1ZTGA@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_260461_37 861299.J421_2843 3.761e-89 305.0 COG0631@1|root,COG0631@2|Bacteria,1ZT1X@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS2_k127_260461_92 680646.RMDY18_19540 1.441e-10 74.0 COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,1W98P@1268|Micrococcaceae 201174|Actinobacteria T Forkhead associated domain fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - - - - - - - - - - FHA,Yop-YscD_cpl CMS2_k127_260461_41 861299.J421_2831 8.272e-80 273.0 COG0785@1|root,COG0785@2|Bacteria,1ZTJC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome C biogenesis protein transmembrane region - - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD CMS2_k127_260461_40 1379698.RBG1_1C00001G0708 6.408e-81 280.0 COG0010@1|root,COG0010@2|Bacteria,2NPGU@2323|unclassified Bacteria 2|Bacteria E Arginase family speB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase CMS2_k127_260461_56 926550.CLDAP_14190 7.568e-64 223.0 COG1945@1|root,COG1945@2|Bacteria 2|Bacteria I arginine decarboxylase activity pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC CMS2_k127_260461_7 997346.HMPREF9374_0940 3.877e-160 533.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,27AXP@186824|Thermoactinomycetaceae 91061|Bacilli L helicase superfamily c-terminal domain priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII CMS2_k127_260461_72 861299.J421_2820 9.061e-36 145.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - MetW,Methyltransf_11,Methyltransf_20,Methyltransf_23,Methyltransf_25,Methyltransf_31 CMS2_k127_260461_42 861299.J421_2819 1.216e-78 274.0 COG0123@1|root,COG0123@2|Bacteria,1ZSKN@142182|Gemmatimonadetes 142182|Gemmatimonadetes BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl CMS2_k127_260461_96 379066.GAU_0914 6.113e-05 49.0 2C3VP@1|root,2ZRAS@2|Bacteria,1ZU7P@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_260461_90 379066.GAU_0913 6.026e-14 75.0 2FC5K@1|root,3449E@2|Bacteria,1ZU4V@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_260461_24 861299.J421_2812 2.44e-115 389.0 COG1164@1|root,COG1164@2|Bacteria 2|Bacteria E metalloendopeptidase activity - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - - CMS2_k127_260461_3 880073.Calab_2803 5.91e-209 663.0 COG0423@1|root,COG0423@2|Bacteria,2NNN9@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSB619.SA_RS07880 HGTP_anticodon,tRNA-synt_2b CMS2_k127_260461_71 756272.Plabr_3437 1.608e-37 145.0 COG2010@1|root,COG2010@2|Bacteria,2J3TA@203682|Planctomycetes 203682|Planctomycetes C Haem-binding domain - - - - - - - - - - - - Haem_bd CMS2_k127_260461_86 1382315.JPOI01000001_gene1249 7.545e-17 85.0 COG3232@1|root,COG3232@2|Bacteria,1V8CK@1239|Firmicutes,4HIUF@91061|Bacilli,1WGJ0@129337|Geobacillus 91061|Bacilli E 5-carboxymethyl-2-hydroxymuconate isomerase hpcD - 5.3.3.10 ko:K01826 ko00350,ko01120,ko01220,map00350,map01120,map01220 M00533 R04379,R04482 RC01141,RC01162 ko00000,ko00001,ko00002,ko01000 - - - CHMI CMS2_k127_260461_62 1122604.JONR01000025_gene4577 1.001e-58 209.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria,1X6PT@135614|Xanthomonadales 135614|Xanthomonadales S phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - - - - - - - - - - Macro CMS2_k127_260461_46 1121918.ARWE01000001_gene1733 8.359e-75 279.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,43VZY@69541|Desulfuromonadales 28221|Deltaproteobacteria D Chain length determinant protein wzc2 - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,ParA,Wzz CMS2_k127_260461_6 861299.J421_2807 3.942e-163 525.0 COG0104@1|root,COG0104@2|Bacteria,1ZSNV@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt CMS2_k127_260461_48 861299.J421_2804 4.645e-69 244.0 COG0329@1|root,COG0329@2|Bacteria,1ZTGV@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Dihydrodipicolinate synthetase family - - - - - - - - - - - - DHDPS CMS2_k127_260461_18 861299.J421_2803 2.203e-122 402.0 COG2805@1|root,COG2805@2|Bacteria,1ZT2Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS2_k127_260461_11 861299.J421_2799 2.726e-135 437.0 COG0180@1|root,COG0180@2|Bacteria,1ZT3P@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b CMS2_k127_260461_54 1379270.AUXF01000004_gene3006 1.085e-65 234.0 COG0483@1|root,COG0483@2|Bacteria,1ZTQA@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P CMS2_k127_260461_31 861299.J421_2796 3.728e-98 328.0 COG0024@1|root,COG0024@2|Bacteria,1ZTC1@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Metallopeptidase family M24 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 CMS2_k127_260461_5 379066.GAU_0893 1.366e-171 548.0 COG0201@1|root,COG0201@2|Bacteria,1ZSYZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY CMS2_k127_260461_67 1379270.AUXF01000004_gene3013 7.984e-43 161.0 COG0200@1|root,COG0200@2|Bacteria,1ZTP0@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A CMS2_k127_260461_93 861299.J421_2792 3.981e-10 65.0 COG1841@1|root,COG1841@2|Bacteria,1ZU4E@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L30p/L7e - - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 CMS2_k127_260461_55 379066.GAU_0890 1.639e-64 227.0 COG0098@1|root,COG0098@2|Bacteria,1ZTHD@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C CMS2_k127_260461_73 1123252.ATZF01000011_gene3259 2.053e-33 132.0 COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,4HIGF@91061|Bacilli,27C1D@186824|Thermoactinomycetaceae 91061|Bacilli J Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p CMS2_k127_260461_52 1385935.N836_33640 6.158e-67 232.0 COG0097@1|root,COG0097@2|Bacteria,1G4ZT@1117|Cyanobacteria,1H8H4@1150|Oscillatoriales 1117|Cyanobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rpl6 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 CMS2_k127_260461_69 391625.PPSIR1_23859 2.254e-40 153.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2WPDP@28221|Deltaproteobacteria,2YVKK@29|Myxococcales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 CMS2_k127_260461_81 880073.Calab_2139 1.061e-23 103.0 COG0199@1|root,COG0199@2|Bacteria,2NPW7@2323|unclassified Bacteria 2|Bacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 CMS2_k127_260461_43 861299.J421_2786 3.32e-78 266.0 COG0094@1|root,COG0094@2|Bacteria,1ZSTZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C CMS2_k127_260461_78 379066.GAU_0884 1.565e-29 121.0 COG0198@1|root,COG0198@2|Bacteria,1ZTRE@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 CMS2_k127_260461_61 861299.J421_2784 4.364e-59 206.0 COG0093@1|root,COG0093@2|Bacteria,1ZTPT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 CMS2_k127_260461_82 1379270.AUXF01000004_gene3024 8.111e-23 100.0 COG0186@1|root,COG0186@2|Bacteria,1ZU1B@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 CMS2_k127_260461_94 379066.GAU_0881 1.414e-08 59.0 COG0255@1|root,COG0255@2|Bacteria,1ZU5T@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal L29 protein rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 CMS2_k127_260461_59 926692.AZYG01000040_gene1588 2.962e-61 213.0 COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,3WAKN@53433|Halanaerobiales 186801|Clostridia J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 CMS2_k127_260461_25 379066.GAU_0879 1.132e-108 354.0 COG0092@1|root,COG0092@2|Bacteria,1ZTFT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C CMS2_k127_260461_74 1379270.AUXF01000004_gene3028 4.434e-33 131.0 COG0091@1|root,COG0091@2|Bacteria,1ZTVF@142182|Gemmatimonadetes 142182|Gemmatimonadetes J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 CMS2_k127_260461_70 861299.J421_2778 4.828e-40 149.0 COG0185@1|root,COG0185@2|Bacteria,1ZU04@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 CMS2_k127_260461_19 379066.GAU_0876 8.636e-120 391.0 COG0090@1|root,COG0090@2|Bacteria,1ZSUP@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C CMS2_k127_260461_80 861299.J421_2776 5.083e-24 105.0 COG0089@1|root,COG0089@2|Bacteria,1ZTWN@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 CMS2_k127_260461_57 1379270.AUXF01000004_gene3032 8.107e-64 228.0 COG0088@1|root,COG0088@2|Bacteria,1ZSSW@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 CMS2_k127_260461_53 1379270.AUXF01000004_gene3033 8.713e-67 235.0 COG0087@1|root,COG0087@2|Bacteria,1ZSW4@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 CMS2_k127_260461_65 861299.J421_2773 6.72e-49 175.0 COG0051@1|root,COG0051@2|Bacteria,1ZTS9@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 CMS2_k127_260461_89 1449126.JQKL01000050_gene2673 4.67e-15 74.0 COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,267PG@186813|unclassified Clostridiales 186801|Clostridia J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 CMS2_k127_2608439_1 1123248.KB893359_gene2154 6.232e-57 205.0 COG0726@1|root,COG0726@2|Bacteria,4NJK7@976|Bacteroidetes 976|Bacteroidetes G PFAM Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 CMS2_k127_2608439_0 504472.Slin_0603 3.19e-122 406.0 COG0399@1|root,COG0399@2|Bacteria,4NG9W@976|Bacteroidetes,47NYY@768503|Cytophagia 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 CMS2_k127_2608439_2 1144275.COCOR_01812 1.348e-50 197.0 COG1680@1|root,COG1680@2|Bacteria,1RGG3@1224|Proteobacteria 1224|Proteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase CMS2_k127_2608439_4 1280954.HPO_12178 2.257e-07 62.0 COG4319@1|root,COG4319@2|Bacteria,1RDBF@1224|Proteobacteria,2U7AM@28211|Alphaproteobacteria,43Y3X@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 CMS2_k127_2660900_4 886377.Murru_2891 3.51e-08 58.0 2BWT4@1|root,2ZJZW@2|Bacteria,4NMBQ@976|Bacteroidetes,1I1I9@117743|Flavobacteriia 976|Bacteroidetes S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 CMS2_k127_2660900_0 861299.J421_4135 2.906e-145 490.0 COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_2660900_1 1379270.AUXF01000002_gene1589 3.223e-20 91.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_2660900_2 379066.GAU_3920 4.896e-20 108.0 COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,1ZTYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Leishmanolysin - - - - - - - - - - - - Peptidase_M8 CMS2_k127_2660900_3 224911.27356208 5.298e-13 85.0 COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TV0C@28211|Alphaproteobacteria,3JS2H@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria QU FecR protein - - - - - - - - - - - - Cadherin_3,FecR,HemolysinCabind,Laminin_G_3,VWA CMS2_k127_2660900_5 1211114.ALIP01000088_gene767 4.345e-06 62.0 COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,1PYUK@1224|Proteobacteria,1S0VV@1236|Gammaproteobacteria,1X5W9@135614|Xanthomonadales 135614|Xanthomonadales KU Transcriptional regulatory protein, C terminal - - - - - - - - - - - - PD40,Trans_reg_C CMS2_k127_26624_14 861299.J421_0779 5.649e-45 179.0 COG0652@1|root,COG0652@2|Bacteria,1ZTYX@142182|Gemmatimonadetes 142182|Gemmatimonadetes O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase CMS2_k127_26624_3 234267.Acid_0605 6.054e-181 591.0 COG2366@1|root,COG2366@2|Bacteria,3Y38M@57723|Acidobacteria 57723|Acidobacteria S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase CMS2_k127_26624_17 204669.Acid345_2605 1.873e-37 147.0 COG1913@1|root,COG1913@2|Bacteria,3Y880@57723|Acidobacteria 57723|Acidobacteria S Peptidase family M54 - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 CMS2_k127_26624_4 945713.IALB_2429 5.032e-167 536.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02481,ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_26624_7 204669.Acid345_2603 1.507e-114 388.0 COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria,2JP3M@204432|Acidobacteriia 57723|Acidobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA CMS2_k127_26624_20 1382304.JNIL01000001_gene2775 1.208e-14 78.0 COG3118@1|root,COG3118@2|Bacteria,1VEPC@1239|Firmicutes,4HNXE@91061|Bacilli,27ABM@186823|Alicyclobacillaceae 91061|Bacilli O Protein of unknown function (DUF2847) ytxJ - - - - - - - - - - - DUF2847 CMS2_k127_26624_21 335543.Sfum_2036 7.804e-11 75.0 28VPN@1|root,2ZHRK@2|Bacteria,1P914@1224|Proteobacteria,432EX@68525|delta/epsilon subdivisions,2WXPK@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_26624_12 1047013.AQSP01000051_gene2576 1.809e-64 234.0 COG2220@1|root,COG2220@2|Bacteria,2NRBH@2323|unclassified Bacteria 2|Bacteria S Beta-lactamase superfamily domain folD4 - - - - - - - - - - - Lactamase_B_3 CMS2_k127_26624_1 861299.J421_1696 1.278e-215 694.0 COG2866@1|root,COG2866@2|Bacteria,1ZUNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS2_k127_26624_19 1111728.ATYS01000006_gene1092 1.713e-26 115.0 COG4283@1|root,COG4283@2|Bacteria,1QHXP@1224|Proteobacteria,1S8S9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1706) - - - - - - - - - - - - DUF1706 CMS2_k127_26624_15 1403819.BATR01000036_gene1120 6.324e-43 162.0 COG3695@1|root,COG3695@2|Bacteria 2|Bacteria L enzyme binding - - 3.1.21.7 ko:K05982,ko:K07452 - - - - ko00000,ko01000,ko02048,ko03400 - - - AAA_5,DNA_binding_1,DUF1524,DUF262,F420H2_quin_red CMS2_k127_26624_2 880073.Calab_3693 1.729e-182 592.0 COG1297@1|root,COG1297@2|Bacteria,2NPP0@2323|unclassified Bacteria 2|Bacteria S OPT oligopeptide transporter protein oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT CMS2_k127_26624_8 1230342.CTM_17726 2.699e-112 376.0 COG0786@1|root,COG0786@2|Bacteria,1TQA4@1239|Firmicutes,247WX@186801|Clostridia,36EF4@31979|Clostridiaceae 186801|Clostridia P Catalyzes the sodium-dependent transport of glutamate gltS - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter CMS2_k127_26624_16 575540.Isop_3007 4.859e-39 152.0 COG0727@1|root,COG0727@2|Bacteria,2IZM1@203682|Planctomycetes 203682|Planctomycetes S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC CMS2_k127_26624_18 204669.Acid345_4302 3.009e-35 139.0 COG0346@1|root,COG0346@2|Bacteria,3Y8DH@57723|Acidobacteria,2JNIW@204432|Acidobacteriia 204432|Acidobacteriia E Glyoxalase-like domain - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase CMS2_k127_26624_0 1121930.AQXG01000021_gene1666 9.747e-309 969.0 COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes 976|Bacteroidetes O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 CMS2_k127_26624_10 1047013.AQSP01000106_gene1768 1.608e-81 297.0 COG0405@1|root,COG0405@2|Bacteria,2NP8H@2323|unclassified Bacteria 2|Bacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS2_k127_26624_9 234267.Acid_4612 2.036e-111 376.0 COG3653@1|root,COG3653@2|Bacteria 2|Bacteria Q N-Acyl-D-aspartate D-glutamate deacylase - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 CMS2_k127_26624_11 330214.NIDE1491 2.535e-77 286.0 COG0745@1|root,COG2202@1|root,COG3829@1|root,COG4585@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,COG5002@2|Bacteria,3J12P@40117|Nitrospirae 40117|Nitrospirae T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - ABC_sub_bind,HATPase_c,HisKA_3,PAS_9 CMS2_k127_26624_6 204669.Acid345_0636 7.79e-130 426.0 COG0520@1|root,COG0520@2|Bacteria,3Y2SC@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 CMS2_k127_26624_13 1166018.FAES_3702 8.363e-46 177.0 COG0671@1|root,COG0671@2|Bacteria,4NMQW@976|Bacteroidetes,47PHH@768503|Cytophagia 976|Bacteroidetes I Acid phosphatase homologues - - - - - - - - - - - - PAP2 CMS2_k127_26624_5 584708.Apau_0039 3.904e-148 482.0 COG0538@1|root,COG0538@2|Bacteria,3TACN@508458|Synergistetes 508458|Synergistetes C isocitrate dehydrogenase, NADP-dependent - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS2_k127_2689421_12 493475.GARC_3386 6.804e-166 534.0 COG4257@1|root,COG4935@1|root,COG4257@2|Bacteria,COG4935@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - CHB_HEX_C_1,CotH,DUF5011,HYR,LTD,P_proprotein,SLH CMS2_k127_2689421_65 448385.sce7840 2.329e-09 70.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - - - - - - - - - - OEP CMS2_k127_2689421_55 927658.AJUM01000017_gene3111 9.087e-18 96.0 COG1285@1|root,COG1285@2|Bacteria,4NTPJ@976|Bacteroidetes 976|Bacteroidetes S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 CMS2_k127_2689421_59 1123302.KB904183_gene1032 1.031e-12 79.0 COG5036@1|root,COG5036@2|Bacteria,1V1FZ@1239|Firmicutes,4HJFI@91061|Bacilli 91061|Bacilli P molecular chaperone - - - - - - - - - - - - VTC CMS2_k127_2689421_70 883080.HMPREF9697_01311 2.764e-07 62.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,3JQRQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MA20_16810 - - ko:K18306 ko02024,map02024 M00644 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2.20,2.A.6.2.32,8.A.1 - - HlyD_D23 CMS2_k127_2689421_7 1178825.ALIH01000002_gene1120 9.19e-197 623.0 COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1HY74@117743|Flavobacteriia 976|Bacteroidetes EGP Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family xylE - - - - - - - - - - - Sugar_tr CMS2_k127_2689421_40 379066.GAU_1023 9.917e-43 172.0 COG3121@1|root,COG3121@2|Bacteria 2|Bacteria NU pilus organization - - - - - - - - - - - - ASH,AhpC-TSA,Calx-beta,HemolysinCabind,LVIVD,PPC,PapD_N,Peptidase_S8 CMS2_k127_2689421_46 383381.EH30_15095 2.675e-29 137.0 COG3188@1|root,COG3188@2|Bacteria,1R6ZJ@1224|Proteobacteria,2U0NW@28211|Alphaproteobacteria,2K2TI@204457|Sphingomonadales 204457|Sphingomonadales NU usher protein - - - - - - - - - - - - CarboxypepD_reg CMS2_k127_2689421_71 469382.Hbor_23650 2.568e-05 57.0 COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,23SA0@183963|Halobacteria 183963|Halobacteria L Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex rad50 - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15,AAA_21,AAA_23,SMC_N CMS2_k127_2689421_32 1499967.BAYZ01000009_gene5260 4.541e-73 253.0 2AY4N@1|root,31Q6J@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_2689421_20 378806.STAUR_6147 2.473e-144 464.0 COG0451@1|root,COG0451@2|Bacteria,1RBSM@1224|Proteobacteria,42XUG@68525|delta/epsilon subdivisions,2WTSY@28221|Deltaproteobacteria,2Z25C@29|Myxococcales 28221|Deltaproteobacteria GM NAD(P)H-binding - - - - - - - - - - - - Epimerase CMS2_k127_2689421_6 518766.Rmar_1740 7.456e-208 653.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA CMS2_k127_2689421_27 926561.KB900620_gene2933 4.865e-112 381.0 COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia 186801|Clostridia S Modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD CMS2_k127_2689421_9 1047013.AQSP01000134_gene1334 8.725e-191 606.0 COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria 2|Bacteria S Putative modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD CMS2_k127_2689421_43 760192.Halhy_6309 3.221e-33 149.0 COG4206@1|root,COG4206@2|Bacteria,4NIJS@976|Bacteroidetes 976|Bacteroidetes H COG4206 Outer membrane cobalamin receptor protein - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_2689421_52 1379270.AUXF01000005_gene752 3.912e-25 108.0 COG1173@1|root,COG1173@2|Bacteria 2|Bacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components appC - - ko:K02031,ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N CMS2_k127_2689421_47 926560.KE387023_gene3374 2.963e-29 123.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB_2 CMS2_k127_2689421_16 1144275.COCOR_02903 4.591e-151 487.0 COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,42SM7@68525|delta/epsilon subdivisions,2WP5E@28221|Deltaproteobacteria,2YYGZ@29|Myxococcales 28221|Deltaproteobacteria G Converts alpha-aldose to the beta-anomer galM2 - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim CMS2_k127_2689421_4 1210884.HG799463_gene9540 2.479e-241 771.0 COG3250@1|root,COG3250@2|Bacteria,2IWTW@203682|Planctomycetes 203682|Planctomycetes G Glycosyl hydrolases family 2 - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Glyco_hydro_43 CMS2_k127_2689421_69 706587.Desti_0448 1.827e-07 63.0 COG0784@1|root,COG0784@2|Bacteria,1QUK7@1224|Proteobacteria,431U0@68525|delta/epsilon subdivisions,2WW6W@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg CMS2_k127_2689421_29 1049564.TevJSym_ar00200 2.745e-85 287.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,1J613@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane protein, hemolysin III homolog yqfA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII CMS2_k127_2689421_22 1297865.APJD01000010_gene5025 6.871e-132 430.0 COG3391@1|root,COG3391@2|Bacteria,1MXRF@1224|Proteobacteria,2U1E9@28211|Alphaproteobacteria,3JTTY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S amine dehydrogenase activity - - - - - - - - - - - - NHL CMS2_k127_2689421_56 1379270.AUXF01000007_gene994 1.129e-17 87.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_2689421_23 861299.J421_1410 5.302e-131 435.0 COG0624@1|root,COG0624@2|Bacteria,1ZSYH@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M28 - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS2_k127_2689421_64 1121904.ARBP01000018_gene2688 1.293e-09 68.0 2E0JC@1|root,32W4X@2|Bacteria,4NT47@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - DUF2490 CMS2_k127_2689421_33 572546.Arcpr_1334 5.592e-73 255.0 COG0563@1|root,arCOG01046@2157|Archaea,2XTRG@28890|Euryarchaeota,246UX@183980|Archaeoglobi 183980|Archaeoglobi F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid CMS2_k127_2689421_1 880073.Calab_2405 1.957e-282 883.0 COG3808@1|root,COG3808@2|Bacteria,2NNK9@2323|unclassified Bacteria 2|Bacteria C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA CMS2_k127_2689421_51 891968.Anamo_1817 1.217e-25 116.0 COG2110@1|root,COG2110@2|Bacteria,3TB5Z@508458|Synergistetes 508458|Synergistetes S C-terminal domain of histone - - - - - - - - - - - - Macro CMS2_k127_2689421_42 706587.Desti_0285 2.775e-37 149.0 COG2181@1|root,COG2181@2|Bacteria 2|Bacteria C nitrate reductase activity - - - - - - - - - - - - SLAC1 CMS2_k127_2689421_25 1047013.AQSP01000077_gene2274 1.132e-116 397.0 COG0247@1|root,COG0247@2|Bacteria 2|Bacteria C lactate metabolic process - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 CMS2_k127_2689421_62 1121439.dsat_0371 1.061e-11 78.0 COG0745@1|root,COG0745@2|Bacteria,1NBQZ@1224|Proteobacteria,42V8P@68525|delta/epsilon subdivisions,2WS87@28221|Deltaproteobacteria,2MCPN@213115|Desulfovibrionales 28221|Deltaproteobacteria T Response regulator receiver domain - - - - - - - - - - - - Response_reg CMS2_k127_2689421_24 883.DvMF_2550 6.023e-126 419.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2M8MZ@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,PAS_4,PAS_9,Response_reg CMS2_k127_2689421_45 706587.Desti_0283 2.664e-30 124.0 COG0745@1|root,COG0745@2|Bacteria,1NBQZ@1224|Proteobacteria,42V8P@68525|delta/epsilon subdivisions,2WS87@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg CMS2_k127_2689421_49 1191523.MROS_1026 7.026e-27 116.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - ko:K13640 - - - - ko00000,ko03000 - - - MerR_1 CMS2_k127_2689421_35 706587.Desti_0337 8.231e-62 226.0 COG2181@1|root,COG2181@2|Bacteria,1NFYW@1224|Proteobacteria,42VRY@68525|delta/epsilon subdivisions,2WRZ0@28221|Deltaproteobacteria,2MSFY@213462|Syntrophobacterales 28221|Deltaproteobacteria C Nitrate reductase gamma subunit - - - - - - - - - - - - Nitrate_red_gam CMS2_k127_2689421_5 693661.Arcve_1697 4.052e-223 705.0 COG0247@1|root,arCOG00333@2157|Archaea 2157|Archaea C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K18501 - - - - ko00000 - - - CCG,Fer4_8 CMS2_k127_2689421_13 1121430.JMLG01000004_gene910 1.264e-165 537.0 COG2855@1|root,COG2855@2|Bacteria,1UY2J@1239|Firmicutes,25CFK@186801|Clostridia,260TV@186807|Peptococcaceae 186801|Clostridia S PFAM Uncharacterised protein family UPF0324 - - - - - - - - - - - - Cons_hypoth698 CMS2_k127_2689421_44 1121468.AUBR01000045_gene1808 7.814e-31 130.0 COG1413@1|root,COG1413@2|Bacteria,1VFIG@1239|Firmicutes,24STM@186801|Clostridia,42H7D@68295|Thermoanaerobacterales 186801|Clostridia C lyase activity - - - - - - - - - - - - HEAT_EZ CMS2_k127_2689421_21 530564.Psta_4644 1.936e-138 459.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2IXP2@203682|Planctomycetes 203682|Planctomycetes H Belongs to the precorrin methyltransferase family - - 2.1.1.107,4.2.1.75 ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,TP_methylase CMS2_k127_2689421_61 1265502.KB905930_gene1511 8.962e-12 70.0 COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,2VTXE@28216|Betaproteobacteria,4AEWE@80864|Comamonadaceae 28216|Betaproteobacteria S cobalamin (vitamin B12) biosynthesis CbiX cbiX - 4.99.1.3 ko:K03795 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiX CMS2_k127_2689421_39 1191523.MROS_0637 5.453e-43 166.0 COG2344@1|root,COG2344@2|Bacteria 2|Bacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N CMS2_k127_2689421_37 760568.Desku_1073 6.721e-57 202.0 COG1146@1|root,COG1146@2|Bacteria,1V59C@1239|Firmicutes,24J64@186801|Clostridia,261U8@186807|Peptococcaceae 186801|Clostridia C reductase beta subunit - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4_7,Fer4_9 CMS2_k127_2689421_0 1121430.JMLG01000003_gene656 8.4e-323 996.0 COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia,25ZZD@186807|Peptococcaceae 186801|Clostridia C reductase alpha subunit - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS2_k127_2689421_53 335543.Sfum_1055 1.16e-23 103.0 COG0500@1|root,COG2226@2|Bacteria,1NHMR@1224|Proteobacteria,42XMB@68525|delta/epsilon subdivisions,2WT6Q@28221|Deltaproteobacteria,2MSC2@213462|Syntrophobacterales 28221|Deltaproteobacteria Q Ogr/Delta-like zinc finger - - - - - - - - - - - - Ogr_Delta CMS2_k127_2689421_34 706587.Desti_3831 1.405e-67 239.0 COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,42NM0@68525|delta/epsilon subdivisions,2WM96@28221|Deltaproteobacteria,2MRJH@213462|Syntrophobacterales 28221|Deltaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC CMS2_k127_2689421_15 1121422.AUMW01000005_gene549 4.069e-153 497.0 COG1148@1|root,COG1148@2|Bacteria,1TS8Y@1239|Firmicutes,24CXD@186801|Clostridia,2604G@186807|Peptococcaceae 186801|Clostridia C binding domain - - - ko:K16885 - - - - ko00000 - - - FAD_oxidored,Fer4,Fer4_10,Fer4_7,Fer4_9,NAD_binding_8,Pyr_redox_2 CMS2_k127_2689421_3 387631.Asulf_02109 2.435e-281 883.0 COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi 183980|Archaeoglobi C Heterodisulfide reductase subunit A and related polyferredoxins - - - ko:K16886 - - - - ko00000 - - - Fer4,FlpD,Pyr_redox_2 CMS2_k127_2689421_31 96561.Dole_1001 3.092e-77 274.0 COG1150@1|root,COG1150@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain qmoC - - ko:K16887 - - - - ko00000 - - - Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam CMS2_k127_2689421_8 880072.Desac_0738 2.849e-191 604.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2WJYY@28221|Deltaproteobacteria,2MR3M@213462|Syntrophobacterales 28221|Deltaproteobacteria H Belongs to the sulfate adenylyltransferase family sat - 2.7.1.25,2.7.7.4 ko:K00958,ko:K13811 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 CMS2_k127_2689421_54 1172180.KB911775_gene6345 3.638e-18 89.0 COG1765@1|root,COG1765@2|Bacteria,2IFY4@201174|Actinobacteria 201174|Actinobacteria O PFAM OsmC family protein - - - - - - - - - - - - OsmC CMS2_k127_2689421_38 706587.Desti_1118 2.981e-47 172.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,42SN5@68525|delta/epsilon subdivisions,2WP28@28221|Deltaproteobacteria,2MS2U@213462|Syntrophobacterales 28221|Deltaproteobacteria P DsrC like protein dsrC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC CMS2_k127_2689421_48 1487923.DP73_20900 1.775e-28 121.0 2CDHP@1|root,32RXU@2|Bacteria,1VQ7W@1239|Firmicutes,251NF@186801|Clostridia,265N8@186807|Peptococcaceae 186801|Clostridia S RsbT co-antagonist protein rsbRD N-terminal domain - - - - - - - - - - - - RsbRD_N CMS2_k127_2689421_26 485915.Dret_0235 2.675e-116 383.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria,2M7X4@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Nitrate_red_gam CMS2_k127_2689421_2 706587.Desti_2672 5.889e-282 874.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,42M60@68525|delta/epsilon subdivisions,2WITJ@28221|Deltaproteobacteria,2MQT6@213462|Syntrophobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_8 CMS2_k127_2689421_41 706587.Desti_2671 9.731e-38 146.0 arCOG10385@1|root,32SEM@2|Bacteria,1N1IG@1224|Proteobacteria,42TMW@68525|delta/epsilon subdivisions,2WQBW@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - dsrJ - - - - - - - - - - - - CMS2_k127_2689421_30 933262.AXAM01000094_gene2190 3.528e-82 285.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,42MNU@68525|delta/epsilon subdivisions,2WJRG@28221|Deltaproteobacteria,2MIME@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein dsrO - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_4 CMS2_k127_2689421_19 871963.Desdi_0250 5.899e-148 477.0 COG5557@1|root,COG5557@2|Bacteria,1UYGM@1239|Firmicutes,24EQA@186801|Clostridia,263KI@186807|Peptococcaceae 186801|Clostridia C PFAM Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD CMS2_k127_2689421_10 696369.KI912183_gene2142 9.784e-176 559.0 COG2221@1|root,COG2221@2|Bacteria,1TRP0@1239|Firmicutes,24A5T@186801|Clostridia,260BJ@186807|Peptococcaceae 186801|Clostridia C PFAM nitrite and sulphite reductase 4Fe-4S dsrA - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr CMS2_k127_2689421_14 1121428.DESHY_30086___1 1.501e-155 498.0 COG2221@1|root,COG2221@2|Bacteria,1TZD2@1239|Firmicutes,24DEF@186801|Clostridia,2610K@186807|Peptococcaceae 186801|Clostridia C TIGRFAM sulfite reductase, dissimilatory-type beta subunit dsrB - 1.8.99.5 ko:K11181 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - Fer4,NIR_SIR,NIR_SIR_ferr CMS2_k127_2689421_11 331678.Cphamn1_1855 2.979e-172 557.0 COG0493@1|root,COG0493@2|Bacteria,1FDFY@1090|Chlorobi 1090|Chlorobi C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2 CMS2_k127_2689421_18 880072.Desac_1620 2.239e-148 489.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MQYU@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 CMS2_k127_2689421_50 511062.GU3_03745 3.999e-26 114.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1Y3WC@135624|Aeromonadales 135624|Aeromonadales H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG2 - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase CMS2_k127_2689421_57 1234595.C725_1566 1.193e-15 91.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,4BPKY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase CMS2_k127_2689421_67 28444.JODQ01000014_gene6717 1.976e-08 68.0 COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4EH7H@85012|Streptosporangiales 201174|Actinobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0008150,GO:0040007 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH CMS2_k127_2689421_28 391615.ABSJ01000039_gene1926 4.275e-111 368.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1J4YW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD CMS2_k127_2689421_36 1120973.AQXL01000116_gene281 2.076e-60 220.0 COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,4H9TV@91061|Bacilli,278YD@186823|Alicyclobacillaceae 91061|Bacilli H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC CMS2_k127_2689421_17 1449126.JQKL01000032_gene1246 7.706e-149 488.0 COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,267U3@186813|unclassified Clostridiales 186801|Clostridia E Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS2_k127_2689421_63 1121472.AQWN01000003_gene1428 8.473e-11 64.0 COG5561@1|root,COG5561@2|Bacteria,1VBTY@1239|Firmicutes,24Q06@186801|Clostridia,2654V@186807|Peptococcaceae 186801|Clostridia S CGGC - - - - - - - - - - - - CGGC CMS2_k127_2718694_5 767817.Desgi_2339 6.703e-118 388.0 COG1409@1|root,COG1409@2|Bacteria,1U2MN@1239|Firmicutes,24802@186801|Clostridia 186801|Clostridia S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos CMS2_k127_2718694_0 1379270.AUXF01000001_gene1864 9.433e-184 586.0 COG0006@1|root,COG0006@2|Bacteria 2|Bacteria E proline dipeptidase activity - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 CMS2_k127_2718694_10 861299.J421_0787 2.018e-65 235.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS2_k127_2718694_3 293826.Amet_1624 3.999e-128 426.0 COG1502@1|root,COG1502@2|Bacteria,1TQ2Q@1239|Firmicutes,24D0N@186801|Clostridia,36QTZ@31979|Clostridiaceae 186801|Clostridia I PLD-like domain - - - - - - - - - - - - PLDc_2 CMS2_k127_2718694_1 861299.J421_1760 1.435e-167 565.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_2718694_7 1379270.AUXF01000001_gene2556 7.607e-95 321.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000001_gene2556|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_2718694_16 1110697.NCAST_18_00830 3.174e-13 81.0 28SI0@1|root,2ZEUB@2|Bacteria,2GNT0@201174|Actinobacteria,4FWWF@85025|Nocardiaceae 201174|Actinobacteria S Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867 CMS2_k127_2718694_8 1254432.SCE1572_26550 3.371e-69 245.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,42RCM@68525|delta/epsilon subdivisions,2WN89@28221|Deltaproteobacteria,2YVX5@29|Myxococcales 28221|Deltaproteobacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg CMS2_k127_2718694_9 234267.Acid_2196 2.762e-66 241.0 COG2972@1|root,COG2972@2|Bacteria,3Y4IB@57723|Acidobacteria 57723|Acidobacteria T Histidine kinase - - - - - - - - - - - - His_kinase CMS2_k127_2718694_15 1117318.PRUB_08200 1.41e-20 96.0 COG1695@1|root,COG1695@2|Bacteria,1N4DF@1224|Proteobacteria,1SBH1@1236|Gammaproteobacteria,2Q31Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K transcriptional regulators - - - - - - - - - - - - PadR CMS2_k127_2718694_4 861299.J421_6141 1.227e-119 418.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6141|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_2718694_13 383372.Rcas_2326 4.201e-32 136.0 COG4870@1|root,COG4932@1|root,COG5513@1|root,COG4870@2|Bacteria,COG4932@2|Bacteria,COG5513@2|Bacteria,2GA24@200795|Chloroflexi,377PH@32061|Chloroflexia 32061|Chloroflexia MO Carboxypeptidase regulatory-like domain - - - ko:K14475 ko05143,map05143 - - - ko00000,ko00001 - - - CarboxypepD_reg CMS2_k127_2718694_12 1121028.ARQE01000005_gene2826 1.517e-56 201.0 COG4104@1|root,COG4104@2|Bacteria,1N2DB@1224|Proteobacteria 1224|Proteobacteria S PAAR motif - - - - - - - - - - - - PAAR_motif CMS2_k127_2718694_6 1123242.JH636435_gene1504 2.897e-104 349.0 COG0500@1|root,COG2226@2|Bacteria,2J1W2@203682|Planctomycetes 203682|Planctomycetes Q Methyltransferase domain - - - - - - - - - - - - - CMS2_k127_2718694_14 1487953.JMKF01000079_gene4147 3.448e-25 119.0 COG0656@1|root,COG0656@2|Bacteria,1G6K0@1117|Cyanobacteria,1HCQA@1150|Oscillatoriales 1117|Cyanobacteria S Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157,Ntox11 CMS2_k127_2718694_17 1117647.M5M_13885 4.392e-05 51.0 2FAMS@1|root,342VJ@2|Bacteria,1NZFT@1224|Proteobacteria,1SQEI@1236|Gammaproteobacteria 1117647.M5M_13885|- - - - - - - - - - - - - - - - CMS2_k127_2718694_11 234267.Acid_0241 7.613e-59 210.0 COG1716@1|root,COG1716@2|Bacteria 2|Bacteria T histone H2A K63-linked ubiquitination - - - ko:K11894 - - - - ko00000,ko02044 3.A.23.1 - - DUF3662,FHA CMS2_k127_2718694_2 686340.Metal_3088 6.366e-152 499.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria,1XEX4@135618|Methylococcales 135618|Methylococcales S Phage late control gene D protein (GPD) - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD CMS2_k127_2735615_4 234267.Acid_4525 7.043e-13 73.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZR@57723|Acidobacteria 57723|Acidobacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_2735615_3 349521.HCH_03926 3.357e-17 90.0 COG0454@1|root,COG0456@2|Bacteria,1R8SB@1224|Proteobacteria,1T3AU@1236|Gammaproteobacteria,1XPI1@135619|Oceanospirillales 135619|Oceanospirillales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 CMS2_k127_2735615_1 1410653.JHVC01000021_gene1281 6.896e-72 254.0 COG1404@1|root,COG1404@2|Bacteria,1UFB1@1239|Firmicutes,24DCR@186801|Clostridia,36H0Y@31979|Clostridiaceae 186801|Clostridia O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8 CMS2_k127_2735615_0 1123278.KB893581_gene972 7.222e-93 323.0 COG1680@1|root,COG1680@2|Bacteria,4NGKK@976|Bacteroidetes,47N9R@768503|Cytophagia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase,DUF3471,TPR_2 CMS2_k127_2735615_2 452637.Oter_1887 1.056e-47 183.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_2773676_1 1242864.D187_005748 4.193e-95 324.0 COG1680@1|root,COG1729@1|root,COG1680@2|Bacteria,COG1729@2|Bacteria,1R49D@1224|Proteobacteria 1224|Proteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase,DUF3471,TPR_2 CMS2_k127_2773676_0 1297742.A176_06446 2.701e-130 441.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_2853901_1 861299.J421_0379 6.985e-178 567.0 COG2721@1|root,COG2721@2|Bacteria 2|Bacteria G sulfolactate sulfo-lyase activity uxaA - 4.2.1.42,4.2.1.7 ko:K01685,ko:K01708 ko00040,ko00053,ko01100,map00040,map00053,map01100 M00631 R01540,R05608 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF CMS2_k127_2853901_3 861299.J421_5614 2.294e-95 321.0 COG1082@1|root,COG1082@2|Bacteria 2|Bacteria G myo-inosose-2 dehydratase activity - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N CMS2_k127_2853901_0 926549.KI421517_gene2782 3.939e-213 670.0 COG0673@1|root,COG0673@2|Bacteria,4NIF1@976|Bacteroidetes,47JIW@768503|Cytophagia 976|Bacteroidetes S Oxidoreductase family, C-terminal alpha beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS2_k127_2853901_2 861299.J421_1624 2.144e-152 494.0 COG0673@1|root,COG0673@2|Bacteria,1ZSW3@142182|Gemmatimonadetes 2|Bacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS2_k127_2853901_4 1090319.KE386571_gene1007 3.311e-17 83.0 COG1082@1|root,COG2152@1|root,COG1082@2|Bacteria,COG2152@2|Bacteria,1PECC@1224|Proteobacteria,2V706@28211|Alphaproteobacteria,2K2AA@204457|Sphingomonadales 204457|Sphingomonadales G Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 CMS2_k127_2883282_1 604331.AUHY01000031_gene2365 4.891e-30 130.0 COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG3706@2|Bacteria,1WJX7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T TIGRFAM diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - GGDEF,TPR_10,TPR_12,TPR_7,TPR_8 CMS2_k127_2883282_0 518766.Rmar_0118 1.114e-156 510.0 COG2939@1|root,COG2939@2|Bacteria,4NF48@976|Bacteroidetes,1FJ5Z@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 CMS2_k127_2901523_16 292459.STH485 1.034e-05 56.0 COG3025@1|root,COG3025@2|Bacteria 2|Bacteria S triphosphatase activity ygiF - 3.6.1.25 ko:K18446 - - - - ko00000,ko01000 - - - CHAD,CYTH CMS2_k127_2901523_12 388467.A19Y_3024 3.615e-59 209.0 COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria,1HB1V@1150|Oscillatoriales 1117|Cyanobacteria O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR CMS2_k127_2901523_13 1380394.JADL01000009_gene3396 1.86e-28 119.0 COG1786@1|root,COG1786@2|Bacteria,1NE20@1224|Proteobacteria,2VGP3@28211|Alphaproteobacteria,2JXB6@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function DUF126 - - - - - - - - - - - - DUF126 CMS2_k127_2901523_4 570952.ATVH01000013_gene3076 2.035e-176 563.0 COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria,2JS02@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF521) - - - - - - - - - - - - DUF521 CMS2_k127_2901523_1 1168034.FH5T_01095 1.14e-245 771.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia 976|Bacteroidetes E Glutamate formimidoyltransferase ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N CMS2_k127_2901523_9 472759.Nhal_3494 2.001e-73 261.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M20A family. ArgE subfamily - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS2_k127_2901523_10 1042163.BRLA_c027510 5.819e-68 237.0 COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,4HBM0@91061|Bacilli,26QI7@186822|Paenibacillaceae 91061|Bacilli S Catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins ytkL - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 CMS2_k127_2901523_11 861299.J421_3108 1.767e-60 223.0 2F044@1|root,33T7T@2|Bacteria,1ZTDC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_2901523_0 861299.J421_1753 0.0 1047.0 COG0446@1|root,COG4888@1|root,COG0446@2|Bacteria,COG4888@2|Bacteria 2|Bacteria G ASPIC UnbV domain protein - - - - - - - - - - - - FG-GAP,Pyr_redox_2,UnbV_ASPIC,VCBS CMS2_k127_2901523_7 292459.STH3178 4.162e-159 511.0 COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia 186801|Clostridia E Aminotransferase - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 CMS2_k127_2901523_17 357809.Cphy_2506 0.0007833 48.0 COG4640@1|root,COG4640@2|Bacteria,1UVAE@1239|Firmicutes,2591W@186801|Clostridia,22382@1506553|Lachnoclostridium 186801|Clostridia S response to antibiotic - - - - - - - - - - - - - CMS2_k127_2901523_8 1121403.AUCV01000084_gene3377 7.004e-134 459.0 COG1305@1|root,COG1305@2|Bacteria,1Q712@1224|Proteobacteria,433SV@68525|delta/epsilon subdivisions,2WYAY@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core CMS2_k127_2901523_2 1265313.HRUBRA_00684 2.723e-179 576.0 COG1473@1|root,COG1473@2|Bacteria,1MX6N@1224|Proteobacteria,1RP3N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S amidohydrolase abgB - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 CMS2_k127_2901523_15 682795.AciX8_4833 1.304e-14 80.0 COG1695@1|root,COG1695@2|Bacteria,3Y8CC@57723|Acidobacteria,2JP3G@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_2901523_5 251221.35211765 5.736e-172 574.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_2901523_6 861299.J421_5759 6.85e-162 536.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_2901523_3 1379270.AUXF01000002_gene1577 6.079e-177 580.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_2901523_14 861299.J421_5846 3.732e-25 112.0 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS2_k127_3021619_2 565045.NOR51B_2777 2.228e-127 424.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1T3SF@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF CMS2_k127_3021619_1 926550.CLDAP_00250 3.581e-133 441.0 COG0160@1|root,COG0160@2|Bacteria 2|Bacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS2_k127_3021619_0 448385.sce6401 3.2e-184 589.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria,2YUP4@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde dehydrogenase family mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS2_k127_306560_15 1379270.AUXF01000007_gene968 1.143e-97 328.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene968|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_306560_12 324602.Caur_1131 5.383e-103 357.0 COG2866@1|root,COG2866@2|Bacteria,2G7PS@200795|Chloroflexi,376WU@32061|Chloroflexia 32061|Chloroflexia E PFAM peptidase M14, carboxypeptidase A - - - - - - - - - - - - Peptidase_M14 CMS2_k127_306560_32 526218.Sterm_2685 1.825e-41 161.0 COG4126@1|root,COG4126@2|Bacteria 2|Bacteria E flavin adenine dinucleotide binding - - - ko:K14591 - - - - ko00000 - - - AroM CMS2_k127_306560_9 70601.3257465 1.423e-120 395.0 arCOG05881@1|root,arCOG05881@2157|Archaea,2Y45R@28890|Euryarchaeota,244WX@183968|Thermococci 183968|Thermococci S Protein of unknown function (DUF1177) - - - - - - - - - - - - DUF1177 CMS2_k127_306560_4 264732.Moth_0209 1.386e-191 612.0 COG1297@1|root,COG1297@2|Bacteria,1TSK9@1239|Firmicutes,249HK@186801|Clostridia 186801|Clostridia S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT CMS2_k127_306560_38 1173028.ANKO01000155_gene4497 2.344e-26 121.0 COG0457@1|root,COG0457@2|Bacteria 1173028.ANKO01000155_gene4497|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_306560_44 338966.Ppro_1244 0.0007513 51.0 COG0810@1|root,COG0810@2|Bacteria,1QX76@1224|Proteobacteria,42V4D@68525|delta/epsilon subdivisions,2WRH8@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins mxcH - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec CMS2_k127_306560_28 909663.KI867150_gene596 1.126e-51 197.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria,2MQHC@213462|Syntrophobacterales 28221|Deltaproteobacteria O XdhC and CoxI family - - - ko:K07402 - - - - ko00000 - - - NTP_transf_3,XdhC_C,XdhC_CoxI CMS2_k127_306560_24 243231.GSU2744 5.358e-70 252.0 COG0477@1|root,COG0477@2|Bacteria,1QWSX@1224|Proteobacteria,43C55@68525|delta/epsilon subdivisions,2X7FI@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP MFS/sugar transport protein - - - - - - - - - - - - MFS_1 CMS2_k127_306560_36 1267535.KB906767_gene1916 1.643e-32 129.0 COG1695@1|root,COG1695@2|Bacteria,3Y5C5@57723|Acidobacteria,2JNCX@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_306560_3 234267.Acid_3515 4.832e-225 728.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_306560_26 1121405.dsmv_1663 2.49e-58 222.0 COG5557@1|root,COG5557@2|Bacteria,1QURB@1224|Proteobacteria,43BT1@68525|delta/epsilon subdivisions,2X73S@28221|Deltaproteobacteria,2MMX3@213118|Desulfobacterales 28221|Deltaproteobacteria C Pfam Polysulphide reductase, NrfD actF - - - - - - - - - - - - CMS2_k127_306560_40 1297742.A176_05067 1.249e-20 100.0 COG2010@1|root,COG2010@2|Bacteria,1RHGQ@1224|Proteobacteria 1224|Proteobacteria C cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 CMS2_k127_306560_37 861299.J421_3628 8.066e-31 128.0 COG2010@1|root,COG2010@2|Bacteria,1ZTMS@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF3341) - - - - - - - - - - - - DUF3341 CMS2_k127_306560_5 379066.GAU_2035 7.029e-182 578.0 COG5557@1|root,COG5557@2|Bacteria,1ZSN2@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD CMS2_k127_306560_1 861299.J421_3630 9.646e-251 807.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal CMS2_k127_306560_34 765869.BDW_05535 3.912e-36 145.0 COG3303@1|root,COG3303@2|Bacteria,1QY22@1224|Proteobacteria,43C9D@68525|delta/epsilon subdivisions,2MTWU@213481|Bdellovibrionales,2WQ1C@28221|Deltaproteobacteria 213481|Bdellovibrionales C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 CMS2_k127_306560_25 861299.J421_3632 3.313e-63 226.0 COG2159@1|root,COG2159@2|Bacteria,1ZTHS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S amidohydrolase - - - - - - - - - - - - - CMS2_k127_306560_14 861299.J421_3633 7.619e-98 327.0 COG2159@1|root,COG2159@2|Bacteria,1ZSXA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 CMS2_k127_306560_17 379066.GAU_2040 1.031e-93 323.0 COG0001@1|root,COG0001@2|Bacteria,1ZSWU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS2_k127_306560_33 1121013.P873_11755 8.589e-37 148.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1X4VZ@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase CMS2_k127_306560_8 861299.J421_3636 2.656e-135 465.0 2AEF2@1|root,314A1@2|Bacteria,1ZSNZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Heparinase II/III-like protein - - - - - - - - - - - - Hepar_II_III CMS2_k127_306560_29 869210.Marky_1653 6.569e-51 193.0 COG2605@1|root,COG2605@2|Bacteria,1WKER@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S COGs COG2605 kinase related to galactokinase and mevalonate kinase - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N CMS2_k127_306560_7 861299.J421_3637 1.071e-138 461.0 COG0747@1|root,COG0747@2|Bacteria,1ZTAS@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 CMS2_k127_306560_19 290512.Paes_0521 4.887e-83 288.0 COG0601@1|root,COG0601@2|Bacteria,1FDDB@1090|Chlorobi 1090|Chlorobi P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS2_k127_306560_23 882.DVU_2462 3.3e-72 254.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2M8HR@213115|Desulfovibrionales 28221|Deltaproteobacteria EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N CMS2_k127_306560_42 332101.JIBU02000032_gene3036 4.326e-15 89.0 COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,36DM2@31979|Clostridiaceae 186801|Clostridia O PDZ DHR GLGF domain protein htrA - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS2_k127_306560_41 1463857.JOFZ01000012_gene1464 2.908e-17 96.0 COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,2GKEU@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K01990,ko:K21397 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC_tran,FHA,Yop-YscD_cpl CMS2_k127_306560_20 1379270.AUXF01000005_gene462 1.4e-80 291.0 COG0515@1|root,COG0515@2|Bacteria,1ZTB4@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_306560_22 1128421.JAGA01000002_gene944 1.109e-73 261.0 COG0438@1|root,COG0438@2|Bacteria,2NR08@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS2_k127_306560_13 1121930.AQXG01000001_gene1127 1.853e-100 334.0 COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,1IPIY@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase pabB - 3.5.1.53,3.5.1.6 ko:K01431,ko:K12251 ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100 M00046 R00905,R01152,R04666,R08228 RC00096 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase CMS2_k127_306560_0 1121104.AQXH01000001_gene2028 0.0 1173.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IQYT@117747|Sphingobacteriia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran CMS2_k127_306560_27 309807.SRU_0926 1.228e-53 203.0 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1FJ10@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 CMS2_k127_306560_21 1121930.AQXG01000001_gene1200 2.911e-77 280.0 COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS2_k127_306560_39 1254432.SCE1572_01960 5.569e-22 104.0 COG1309@1|root,COG1309@2|Bacteria,1N6R3@1224|Proteobacteria,42VN1@68525|delta/epsilon subdivisions,2WRVD@28221|Deltaproteobacteria,2YVPX@29|Myxococcales 28221|Deltaproteobacteria K WHG domain - - - - - - - - - - - - TetR_N,WHG CMS2_k127_306560_43 1449069.JMLO01000027_gene3201 2.61e-08 64.0 COG2267@1|root,COG2267@2|Bacteria,2GMY4@201174|Actinobacteria,4G9Q5@85025|Nocardiaceae 201174|Actinobacteria I TAP-like protein - - - - - - - - - - - - Abhydrolase_1 CMS2_k127_306560_16 1254432.SCE1572_33565 7.018e-97 327.0 COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria,2YU3D@29|Myxococcales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 CMS2_k127_306560_11 1254432.SCE1572_13230 3.487e-107 357.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2YUI5@29|Myxococcales 28221|Deltaproteobacteria V ABC transporter - - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran,DUF4162 CMS2_k127_306560_30 1121440.AUMA01000012_gene1387 3.122e-48 190.0 28I4Y@1|root,2Z88D@2|Bacteria,1R95V@1224|Proteobacteria,42RX3@68525|delta/epsilon subdivisions,2WMGE@28221|Deltaproteobacteria,2MECJ@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_306560_31 309807.SRU_0062 1.54e-47 183.0 COG1073@1|root,COG1073@2|Bacteria,4NGCE@976|Bacteroidetes 976|Bacteroidetes S Hydrolase with alpha beta fold protein - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 CMS2_k127_306560_2 1121920.AUAU01000023_gene2395 3.915e-226 719.0 COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity leuD - 4.2.1.3,4.2.1.33,4.2.1.35 ko:K01681,ko:K01703,ko:K01704,ko:K17749 ko00020,ko00290,ko00400,ko00630,ko00660,ko00720,ko00966,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00400,map00630,map00660,map00720,map00966,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00432,M00535,M00740 R01324,R01325,R01900,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170,R10501 RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C CMS2_k127_306560_35 1380355.JNIJ01000013_gene380 7.299e-33 137.0 COG1309@1|root,COG1309@2|Bacteria,1MY9K@1224|Proteobacteria,2U3PH@28211|Alphaproteobacteria,3JXKW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS2_k127_306560_10 316067.Geob_0097 4.014e-112 373.0 COG1064@1|root,COG1064@2|Bacteria,1QVIH@1224|Proteobacteria,42NMX@68525|delta/epsilon subdivisions,2WJGB@28221|Deltaproteobacteria,43TA2@69541|Desulfuromonadales 28221|Deltaproteobacteria C Alanine dehydrogenase/PNT, C-terminal domain bamQ - 1.1.1.368 ko:K07538 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05581 RC00850 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N CMS2_k127_306560_6 1187851.A33M_3194 6.785e-150 482.0 COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.21 ko:K07539 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05593,R05594,R10696 RC01430,RC01431,RC03237 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS2_k127_306560_18 316067.Geob_0099 9.268e-90 302.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS2_k127_3105784_4 391625.PPSIR1_29518 4.271e-43 168.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42S9C@68525|delta/epsilon subdivisions,2WM4G@28221|Deltaproteobacteria,2YU8Y@29|Myxococcales 28221|Deltaproteobacteria Q Dienelactone hydrolase family dlhH2 - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH CMS2_k127_3105784_1 289376.THEYE_A0955 1.865e-125 413.0 COG3876@1|root,COG3876@2|Bacteria 2|Bacteria G Protein conserved in bacteria - - - - - - - - - - - - DUF1343 CMS2_k127_3105784_2 309798.COPRO5265_0451 2.182e-67 246.0 COG0308@1|root,COG0308@2|Bacteria,1VMQ2@1239|Firmicutes 1239|Firmicutes E aminopeptidase N - - - - - - - - - - - - Peptidase_M1 CMS2_k127_3105784_3 941449.dsx2_2529 2.303e-48 189.0 COG3858@1|root,COG3858@2|Bacteria,1PYW7@1224|Proteobacteria,435KI@68525|delta/epsilon subdivisions,2WZYY@28221|Deltaproteobacteria,2M8W6@213115|Desulfovibrionales 28221|Deltaproteobacteria S chitin binding - - - - - - - - - - - - Glyco_hydro_18 CMS2_k127_3105784_7 1408473.JHXO01000011_gene3123 6.944e-09 59.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - AhpC-TSA,Rhodanese,Thioredoxin_8 CMS2_k127_3105784_5 1317122.ATO12_08385 1.247e-29 128.0 COG3043@1|root,COG3043@2|Bacteria,4NG82@976|Bacteroidetes,1HZDY@117743|Flavobacteriia,2YHZ9@290174|Aquimarina 976|Bacteroidetes C Nitrate reductase cytochrome c-type subunit (NapB) - - - ko:K02568 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798 RC02812 ko00000,ko00001,ko00002 - - - Cytochrome_C554,NapB CMS2_k127_3105784_0 1167006.UWK_03288 3.06e-201 642.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2WKKT@28221|Deltaproteobacteria,2MPSR@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal CMS2_k127_3108329_16 666685.R2APBS1_2165 1.194e-05 55.0 2EJ52@1|root,33CW9@2|Bacteria,1PD05@1224|Proteobacteria,1SY6A@1236|Gammaproteobacteria,1X79D@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - CMS2_k127_3108329_10 420662.Mpe_A2683 1.358e-16 87.0 2B14M@1|root,31TIF@2|Bacteria,1RH0J@1224|Proteobacteria,2VTFX@28216|Betaproteobacteria,1KNP8@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function (DUF2938) - - - - - - - - - - - - DUF2938 CMS2_k127_3108329_13 929713.NIASO_13465 3.693e-09 64.0 COG2020@1|root,COG2020@2|Bacteria,4NXS4@976|Bacteroidetes 976|Bacteroidetes O Methyltransferase - - - - - - - - - - - - ICMT,PEMT CMS2_k127_3108329_0 391595.RLO149_c020740 3.289e-60 222.0 COG3439@1|root,COG3439@2|Bacteria,1Q4S0@1224|Proteobacteria,2VB75@28211|Alphaproteobacteria,2P48C@2433|Roseobacter 28211|Alphaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 CMS2_k127_3108329_3 1197906.CAJQ02000047_gene4077 1.814e-33 134.0 COG2329@1|root,COG2329@2|Bacteria,1N2ZS@1224|Proteobacteria,2UEPY@28211|Alphaproteobacteria,3K08M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - - CMS2_k127_3108329_12 1197477.IA57_05825 1.104e-11 68.0 2DZVD@1|root,32VJZ@2|Bacteria,4NUB2@976|Bacteroidetes,1I482@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - ydhR CMS2_k127_3108329_5 543632.JOJL01000012_gene6673 3.156e-28 122.0 COG1917@1|root,COG1917@2|Bacteria,2IRRU@201174|Actinobacteria,4DJUR@85008|Micromonosporales 201174|Actinobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - CMS2_k127_3108329_1 1283284.AZUK01000004_gene3051 2.553e-53 192.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1Y5VF@135624|Aeromonadales 135624|Aeromonadales L Integrase core domain - - - ko:K07482 - - - - ko00000 - - - HTH_38,rve CMS2_k127_3108329_7 1041146.ATZB01000011_gene958 6.239e-23 99.0 2AKNV@1|root,31BFG@2|Bacteria,1NZ2P@1224|Proteobacteria,2USTH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - DUF3237 CMS2_k127_3108329_11 1007103.AFHW01000133_gene6380 2.27e-12 70.0 COG0454@1|root,COG0456@2|Bacteria,1VFWI@1239|Firmicutes,4HNMX@91061|Bacilli,26ZMP@186822|Paenibacillaceae 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 CMS2_k127_3108329_15 1007103.AFHW01000133_gene6380 6.308e-06 52.0 COG0454@1|root,COG0456@2|Bacteria,1VFWI@1239|Firmicutes,4HNMX@91061|Bacilli,26ZMP@186822|Paenibacillaceae 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 CMS2_k127_3108329_8 983545.Glaag_2641 6.397e-22 105.0 COG0739@1|root,COG0739@2|Bacteria,1N19D@1224|Proteobacteria,1S8IP@1236|Gammaproteobacteria,467J8@72275|Alteromonadaceae 1236|Gammaproteobacteria M Peptidase family M23 - - - - - - - - - - - - DUF4124,Peptidase_M23 CMS2_k127_3108329_6 365046.Rta_13280 2.487e-26 111.0 2E3VP@1|root,32YSV@2|Bacteria,1RFZF@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_3108329_4 1045009.AFXQ01000002_gene1581 4.912e-32 129.0 COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria,1WC1D@1268|Micrococcaceae 201174|Actinobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 CMS2_k127_3108329_9 909663.KI867150_gene2328 3.552e-21 96.0 COG2227@1|root,COG2227@2|Bacteria,1QZT3@1224|Proteobacteria,42QXG@68525|delta/epsilon subdivisions,2WMWI@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 CMS2_k127_3119421_19 1121422.AUMW01000003_gene829 1.319e-42 168.0 COG0496@1|root,COG0496@2|Bacteria,1TS2T@1239|Firmicutes,24BI5@186801|Clostridia,260JN@186807|Peptococcaceae 186801|Clostridia S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE CMS2_k127_3119421_21 1118054.CAGW01000009_gene3923 3.885e-39 149.0 2CAQ0@1|root,32RRS@2|Bacteria,1V6RF@1239|Firmicutes,4HK8B@91061|Bacilli 91061|Bacilli S Malonate transporter MadL subunit madL - - - - - - - - - - - MadL CMS2_k127_3119421_9 665959.HMPREF1013_03156 1.473e-111 365.0 28HGK@1|root,2Z7SE@2|Bacteria,1UP9Q@1239|Firmicutes,4HB3M@91061|Bacilli,1ZF4U@1386|Bacillus 91061|Bacilli S Malonate/sodium symporter MadM subunit madM - - - - - - - - - - - MadM CMS2_k127_3119421_3 1396141.BATP01000032_gene4343 1.474e-177 569.0 COG0318@1|root,COG0318@2|Bacteria 2|Bacteria IQ PFAM AMP-dependent synthetase and ligase fadD36 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087 - ko:K12429,ko:K18660,ko:K18661,ko:K18662 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C CMS2_k127_3119421_4 1379270.AUXF01000001_gene2737 9.846e-148 476.0 COG1506@1|root,COG1506@2|Bacteria,1ZSYK@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 CMS2_k127_3119421_6 861299.J421_6092 2.255e-139 459.0 COG1680@1|root,COG1680@2|Bacteria,1ZUKR@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Domain of unknown function (DUF3471) - - - - - - - - - - - - Beta-lactamase,DUF3471 CMS2_k127_3119421_0 861299.J421_5971 4.889e-302 948.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_3119421_15 649638.Trad_2159 1.774e-63 231.0 COG1407@1|root,COG1407@2|Bacteria 2|Bacteria S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,Metallophos_2 CMS2_k127_3119421_11 309807.SRU_2346 2.772e-101 344.0 COG4826@1|root,COG4826@2|Bacteria,4NG1G@976|Bacteroidetes 976|Bacteroidetes O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin CMS2_k127_3119421_14 861299.J421_1230 2.603e-76 276.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_3119421_7 518766.Rmar_1911 2.545e-139 456.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS2_k127_3119421_10 1121930.AQXG01000008_gene175 4.72e-103 351.0 COG4826@1|root,COG4826@2|Bacteria,4NG1G@976|Bacteroidetes,1IRRU@117747|Sphingobacteriia 976|Bacteroidetes O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin CMS2_k127_3119421_28 1313301.AUGC01000007_gene608 3.19e-19 104.0 COG2234@1|root,COG2234@2|Bacteria,4NJCD@976|Bacteroidetes 976|Bacteroidetes S Leucyl aminopeptidase - - 3.4.11.10,3.4.11.6 ko:K19701 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M28 CMS2_k127_3119421_30 1379270.AUXF01000005_gene480 1.189e-16 89.0 2FCTB@1|root,344W9@2|Bacteria,1ZU4K@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3119421_1 1121405.dsmv_1946 1.778e-230 729.0 COG1055@1|root,COG1055@2|Bacteria,1QUC0@1224|Proteobacteria,43BR6@68525|delta/epsilon subdivisions,2WJVM@28221|Deltaproteobacteria,2MIF3@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM sodium sulfate symporter - - - - - - - - - - - - Na_sulph_symp CMS2_k127_3119421_16 1121396.KB893079_gene874 1.982e-51 193.0 COG0517@1|root,COG2204@1|root,COG0517@2|Bacteria,COG2204@2|Bacteria,1NMVW@1224|Proteobacteria,42N24@68525|delta/epsilon subdivisions,2WIQ6@28221|Deltaproteobacteria,2MJ9K@213118|Desulfobacterales 28221|Deltaproteobacteria T CBS domain containing protein - - - - - - - - - - - - CBS,Response_reg CMS2_k127_3119421_24 935567.JAES01000014_gene1558 1.065e-29 134.0 COG3746@1|root,COG3746@2|Bacteria,1R9AP@1224|Proteobacteria,1RS2N@1236|Gammaproteobacteria,1X2Z1@135614|Xanthomonadales 135614|Xanthomonadales P Phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P CMS2_k127_3119421_12 1121406.JAEX01000001_gene424 7.279e-101 349.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2M8XD@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2 CMS2_k127_3119421_25 644282.Deba_2964 4.374e-25 117.0 COG2204@1|root,COG2204@2|Bacteria,1MYQ1@1224|Proteobacteria,42TBS@68525|delta/epsilon subdivisions,2WNQA@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg CMS2_k127_3119421_26 706587.Desti_4442 1.896e-21 106.0 COG2204@1|root,COG2204@2|Bacteria,1QWPT@1224|Proteobacteria,43BUK@68525|delta/epsilon subdivisions,2X75P@28221|Deltaproteobacteria 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS2_k127_3119421_23 1304885.AUEY01000026_gene3554 7.661e-30 136.0 COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2WJS2@28221|Deltaproteobacteria,2MPW7@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 CMS2_k127_3119421_20 1121439.dsat_1821 2.009e-41 161.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2MBXZ@213115|Desulfovibrionales 28221|Deltaproteobacteria O Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C CMS2_k127_3119421_34 60520.HR47_11470 0.0005764 50.0 COG2179@1|root,COG2179@2|Bacteria,1V6KM@1239|Firmicutes,4HGAV@91061|Bacilli,3F46V@33958|Lactobacillaceae 91061|Bacilli S HAD phosphatase, family IIIA yqeG - - ko:K07015 - - - - ko00000 - - - HAD_2,Hydrolase,Hydrolase_like,PGP_phosphatase CMS2_k127_3119421_27 42256.RradSPS_0958 1.531e-20 96.0 2EEAU@1|root,33859@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_3119421_8 1219084.AP014508_gene19 8.458e-138 457.0 COG3653@1|root,COG3653@2|Bacteria 2|Bacteria Q N-Acyl-D-aspartate D-glutamate deacylase - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 CMS2_k127_3119421_31 335543.Sfum_1464 1.219e-10 64.0 COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MR33@213462|Syntrophobacterales 28221|Deltaproteobacteria KT Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,HTH_8,PAS_3,PAS_4,Sigma54_activat CMS2_k127_3119421_2 443143.GM18_0105 1.15e-202 655.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42QGH@68525|delta/epsilon subdivisions,2WKTM@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM multicopper oxidase type 2 - - - - - - - - - - - - Cu-oxidase_2 CMS2_k127_3119421_22 861299.J421_4408 8.592e-34 143.0 2FDKW@1|root,345N6@2|Bacteria,1ZU05@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - - CMS2_k127_3119421_29 861299.J421_4409 4.573e-17 91.0 COG2165@1|root,COG2165@2|Bacteria,1ZU7Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Prokaryotic N-terminal methylation motif - - - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl CMS2_k127_3119421_18 861299.J421_6307 2.406e-47 174.0 COG2165@1|root,COG2165@2|Bacteria,1ZTUY@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Type II secretion system (T2SS), protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG CMS2_k127_3119421_13 861299.J421_4402 3.458e-94 326.0 COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes 2|Bacteria U Type II secretion system (T2SS), protein F xpsF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF CMS2_k127_3119421_5 671143.DAMO_2489 4.477e-147 484.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain xpsE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N CMS2_k127_3119421_17 1379270.AUXF01000005_gene366 8.189e-51 184.0 COG1450@1|root,COG1450@2|Bacteria,1ZT9Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Bacterial type II and III secretion system protein - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N CMS2_k127_314087_10 1144275.COCOR_01587 1.122e-26 113.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PZJ@68525|delta/epsilon subdivisions,2WMGB@28221|Deltaproteobacteria,2YVBK@29|Myxococcales 28221|Deltaproteobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS2_k127_314087_3 1237149.C900_00794 2.299e-67 231.0 COG0432@1|root,COG0432@2|Bacteria,4NNMN@976|Bacteroidetes,47PT0@768503|Cytophagia 976|Bacteroidetes S TIGRFAM secondary thiamine-phosphate synthase enzyme yjbQ - - - - - - - - - - - UPF0047 CMS2_k127_314087_1 204669.Acid345_4590 1.856e-145 473.0 COG1741@1|root,COG1741@2|Bacteria,3Y367@57723|Acidobacteria,2JKXN@204432|Acidobacteriia 204432|Acidobacteriia S Pirin C-terminal cupin domain - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C CMS2_k127_314087_4 861299.J421_2620 4.893e-62 227.0 COG1559@1|root,COG1559@2|Bacteria,1ZTA7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG CMS2_k127_314087_2 1128421.JAGA01000002_gene587 7.516e-84 293.0 COG0013@1|root,COG0013@2|Bacteria,2NPQB@2323|unclassified Bacteria 2|Bacteria J Threonyl and Alanyl tRNA synthetase second additional domain alaS_2 - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS2_k127_314087_11 861299.J421_0120 2.205e-24 121.0 COG3291@1|root,COG3325@1|root,COG3291@2|Bacteria,COG3325@2|Bacteria 2|Bacteria G chitin binding - - 3.1.3.5,3.2.1.14 ko:K01081,ko:K01183,ko:K20276 ko00230,ko00240,ko00520,ko00760,ko01100,ko01110,ko02024,map00230,map00240,map00520,map00760,map01100,map01110,map02024 - R00183,R00511,R00963,R01126,R01206,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02334,R02719,R03346 RC00017,RC00467 ko00000,ko00001,ko01000 - GH18 - F5_F8_type_C,Glyco_hydro_18,NPCBM_assoc,PKD,PPC,Trypsin_2,fn3 CMS2_k127_314087_7 448385.sce3387 2.651e-56 226.0 COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales 28221|Deltaproteobacteria S cellulose binding - - - - - - - - - - - - - CMS2_k127_314087_8 368407.Memar_1212 1.318e-51 211.0 COG3291@1|root,arCOG02527@1|root,arCOG02508@2157|Archaea,arCOG02527@2157|Archaea 2157|Archaea G PFAM PKD domain containing protein - - - - - - - - - - - - Beta_helix,Big_2,Big_5,CHB_HEX_C_1,PKD,PMBR,PQQ_3,Peptidase_S9,Polysacc_deac_1 CMS2_k127_314087_9 1267535.KB906767_gene1916 7.505e-31 125.0 COG1695@1|root,COG1695@2|Bacteria,3Y5C5@57723|Acidobacteria,2JNCX@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_314087_0 234267.Acid_0751 5.856e-224 724.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_3178372_2 1191523.MROS_1826 1.578e-60 214.0 COG1509@1|root,COG1509@2|Bacteria 2|Bacteria E lysine 2,3-aminomutase activity kamA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_14,LAM_C,Radical_SAM CMS2_k127_3178372_5 1121918.ARWE01000001_gene2995 1.091e-27 126.0 COG0454@1|root,COG0456@2|Bacteria,1NEWG@1224|Proteobacteria,42VG1@68525|delta/epsilon subdivisions,2WRCC@28221|Deltaproteobacteria,43UQR@69541|Desulfuromonadales 28221|Deltaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 CMS2_k127_3178372_3 1121918.ARWE01000001_gene2996 8.264e-52 198.0 COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,43U6N@69541|Desulfuromonadales 28221|Deltaproteobacteria M ATP-grasp domain - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C CMS2_k127_3178372_1 1121918.ARWE01000001_gene2997 2.46e-108 361.0 COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,43UHD@69541|Desulfuromonadales 28221|Deltaproteobacteria M ATP-grasp domain - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C CMS2_k127_3178372_0 1499967.BAYZ01000118_gene3300 1.414e-157 505.0 COG1454@1|root,COG1454@2|Bacteria,2NQ5W@2323|unclassified Bacteria 2|Bacteria C Iron-containing alcohol dehydrogenase CT0951 - 1.1.1.1,4.3.3.7 ko:K00001,ko:K01714,ko:K13954 ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230 M00016,M00525,M00526,M00527 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - Fe-ADH CMS2_k127_3178372_4 1499967.BAYZ01000118_gene3301 2.164e-43 162.0 COG1359@1|root,COG1359@2|Bacteria 2|Bacteria S Antibiotic biosynthesis monooxygenase lsrG - 5.3.1.32 ko:K11530 ko02024,map02024 - - - ko00000,ko00001,ko01000 - - - ABM CMS2_k127_3182719_3 861299.J421_6034 1.599e-51 198.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS2_k127_3182719_2 404589.Anae109_3092 1.733e-57 216.0 COG3568@1|root,COG3568@2|Bacteria,1N29G@1224|Proteobacteria 1224|Proteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos CMS2_k127_3182719_0 1047013.AQSP01000138_gene1056 6.85e-140 456.0 COG2502@1|root,COG2502@2|Bacteria,2NNKP@2323|unclassified Bacteria 2|Bacteria E Aspartate-ammonia ligase asnA GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 - R00483 RC00010 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299 AsnA CMS2_k127_3182719_1 1192034.CAP_2759 5.929e-87 322.0 COG0515@1|root,COG3903@1|root,COG0515@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,4389V@68525|delta/epsilon subdivisions,2X3J8@28221|Deltaproteobacteria,2YWAY@29|Myxococcales 28221|Deltaproteobacteria KLT Transcriptional regulator - - - - - - - - - - - - Pkinase CMS2_k127_3187594_18 1379270.AUXF01000003_gene3797 1.48e-05 56.0 COG4932@1|root,COG4932@2|Bacteria 2|Bacteria M domain protein - - - - - - - - - - - - CHU_C CMS2_k127_3187594_1 290397.Adeh_1417 1.68e-210 672.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42PMK@68525|delta/epsilon subdivisions,2X5G7@28221|Deltaproteobacteria,2Z35F@29|Myxococcales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS2_k127_3187594_16 935848.JAEN01000013_gene4099 1.741e-12 77.0 COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2U5HS@28211|Alphaproteobacteria,2PUUG@265|Paracoccus 28211|Alphaproteobacteria S Phosphoribosyl transferase domain - - - ko:K07100 - - - - ko00000 - - - Pribosyltran CMS2_k127_3187594_4 1340493.JNIF01000004_gene560 4.321e-139 474.0 COG2120@1|root,COG2120@2|Bacteria,3Y3BV@57723|Acidobacteria 57723|Acidobacteria S PFAM LmbE family protein - - - - - - - - - - - - PIG-L CMS2_k127_3187594_10 1329516.JPST01000003_gene1164 3.6e-84 297.0 COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,4HABY@91061|Bacilli,27CM5@186824|Thermoactinomycetaceae 91061|Bacilli P Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 CMS2_k127_3187594_11 1227457.C451_18703 2.014e-78 274.0 COG3839@1|root,arCOG00177@2157|Archaea,2XTFK@28890|Euryarchaeota,23S9H@183963|Halobacteria 183963|Halobacteria E COG3842 ABC-type spermidine putrescine transport systems, ATPase components sfuC - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 CMS2_k127_3187594_6 1329516.JPST01000003_gene1162 2.782e-118 407.0 COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HA2U@91061|Bacilli,27CKY@186824|Thermoactinomycetaceae 91061|Bacilli P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 CMS2_k127_3187594_9 861299.J421_3562 7.344e-92 319.0 COG0477@1|root,COG2814@2|Bacteria,1ZT84@142182|Gemmatimonadetes 2|Bacteria EGP Sugar (and other) transporter - - - ko:K08153 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8 - - MFS_1,Sugar_tr CMS2_k127_3187594_17 497321.C664_19151 4.727e-10 63.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,2VUFZ@28216|Betaproteobacteria,2KX2G@206389|Rhodocyclales 206389|Rhodocyclales S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA CMS2_k127_3187594_12 1123368.AUIS01000008_gene2251 3.375e-63 224.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,2NCIJ@225057|Acidithiobacillales 225057|Acidithiobacillales KO Hydrogenase accessory protein HypB - - - ko:K04652 - - - - ko00000,ko03110 - - - cobW CMS2_k127_3187594_0 1382306.JNIM01000001_gene189 1.598e-215 694.0 COG0068@1|root,COG0068@2|Bacteria,2G5QN@200795|Chloroflexi 200795|Chloroflexi O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF CMS2_k127_3187594_15 1906.SFRA_16525 1.911e-23 102.0 COG0298@1|root,COG0298@2|Bacteria,2IMSQ@201174|Actinobacteria 201174|Actinobacteria O Hydrogenase expression formation protein - - - ko:K04653 - - - - ko00000 - - - HupF_HypC CMS2_k127_3187594_3 298653.Franean1_3401 1.069e-164 527.0 COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria 201174|Actinobacteria O hydrogenase expression formation protein HypD hypD - - ko:K04654 - - - - ko00000 - - - HypD CMS2_k127_3187594_5 926550.CLDAP_24400 2.123e-118 390.0 COG0309@1|root,COG0309@2|Bacteria,2G5MV@200795|Chloroflexi 200795|Chloroflexi O hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C CMS2_k127_3187594_14 1379270.AUXF01000001_gene2583 9.323e-33 139.0 COG2067@1|root,COG2067@2|Bacteria,1ZUT4@142182|Gemmatimonadetes 142182|Gemmatimonadetes I long-chain fatty acid transport protein - - - - - - - - - - - - - CMS2_k127_3187594_2 379066.GAU_2748 6.665e-203 650.0 COG4188@1|root,COG4188@2|Bacteria,1ZUJV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Chlorophyllase enzyme - - - - - - - - - - - - Chlorophyllase2 CMS2_k127_3187594_8 929556.Solca_1205 1.852e-110 366.0 COG2367@1|root,COG2367@2|Bacteria,4NDYP@976|Bacteroidetes,1INNE@117747|Sphingobacteriia 976|Bacteroidetes V Beta-lactamase enzyme family - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 CMS2_k127_3187594_7 1379270.AUXF01000001_gene2111 1.158e-110 372.0 COG0624@1|root,COG0624@2|Bacteria,1ZUS9@142182|Gemmatimonadetes 142182|Gemmatimonadetes E M42 glutamyl aminopeptidase - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS2_k127_3187594_13 1279017.AQYJ01000020_gene1292 2.376e-40 153.0 COG0778@1|root,COG0778@2|Bacteria,1MY39@1224|Proteobacteria,1RS8B@1236|Gammaproteobacteria,46DGX@72275|Alteromonadaceae 1236|Gammaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase CMS2_k127_3197226_4 1237149.C900_05924 1.669e-58 216.0 COG0823@1|root,COG0823@2|Bacteria,4NIV7@976|Bacteroidetes,47RCS@768503|Cytophagia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_3197226_0 504472.Slin_3379 0.0 1027.0 COG2866@1|root,COG2866@2|Bacteria,4P1T6@976|Bacteroidetes 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS2_k127_3197226_3 1379270.AUXF01000002_gene1485 9.542e-67 239.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid blaB3 - - - - - - - - - - - Lactamase_B CMS2_k127_3197226_2 234267.Acid_6478 5.458e-99 327.0 COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria 57723|Acidobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - ABC_tran CMS2_k127_3197226_5 234267.Acid_6108 5.622e-33 137.0 COG4798@1|root,COG4798@2|Bacteria 2|Bacteria E methyltransferase - - - - - - - - - - - - Acetyltransf_1,FAD_binding_4,Methyltransf_11,Methyltransf_25,Methyltransf_31,SAM_MT CMS2_k127_3197226_1 452637.Oter_1883 2.111e-163 547.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_3197226_6 234267.Acid_2610 2.914e-16 80.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_3203927_38 1047013.AQSP01000131_gene1807 2.857e-12 72.0 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - - - - - - - - - - - DUF1295,PEMT CMS2_k127_3203927_17 1144275.COCOR_01091 3.291e-90 310.0 COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,42RKM@68525|delta/epsilon subdivisions,2WNVJ@28221|Deltaproteobacteria,2YX74@29|Myxococcales 28221|Deltaproteobacteria E L-asparaginase II - - - - - - - - - - - - Asparaginase_II CMS2_k127_3203927_6 861299.J421_3472 3.376e-127 418.0 COG0536@1|root,COG0536@2|Bacteria,1ZSVS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 CMS2_k127_3203927_23 498761.HM1_2210 1.85e-69 249.0 COG0640@1|root,COG0758@1|root,COG0640@2|Bacteria,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia 186801|Clostridia LU DNA protecting protein DprA dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A CMS2_k127_3203927_13 379066.GAU_1900 4.994e-103 348.0 COG0635@1|root,COG0635@2|Bacteria,1ZSSU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - Radical_SAM CMS2_k127_3203927_9 379066.GAU_1899 1.525e-114 378.0 COG1420@1|root,COG1420@2|Bacteria,1ZTER@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA CMS2_k127_3203927_7 379066.GAU_1898 1.055e-123 407.0 COG0484@1|root,COG0484@2|Bacteria,1ZSVD@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG CMS2_k127_3203927_32 713586.KB900536_gene189 6.865e-39 149.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1WYPB@135613|Chromatiales 135613|Chromatiales FG PFAM Histidine triad (HIT) protein - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT CMS2_k127_3203927_36 379066.GAU_1894 1.176e-20 92.0 COG0828@1|root,COG0828@2|Bacteria,1ZU81@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S21 - - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 CMS2_k127_3203927_4 861299.J421_3463 1.974e-147 495.0 COG1193@1|root,COG1193@2|Bacteria,1ZSWM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr CMS2_k127_3203927_16 667014.Thein_0035 1.453e-95 336.0 COG0358@1|root,COG0358@2|Bacteria,2GHQG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_N,zf-CHC2 CMS2_k127_3203927_40 530564.Psta_2691 8.633e-10 68.0 COG1579@1|root,COG1579@2|Bacteria,2J0BT@203682|Planctomycetes 203682|Planctomycetes S Zn-ribbon protein possibly nucleic acid-binding - - - ko:K07164 - - - - ko00000 - - - zf-RING_7 CMS2_k127_3203927_2 379066.GAU_1889 5.148e-169 548.0 COG0608@1|root,COG0608@2|Bacteria,1ZTGC@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DHH family - - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 CMS2_k127_3203927_29 861299.J421_3458 9.828e-48 178.0 COG0742@1|root,COG0742@2|Bacteria,1ZTVS@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Conserved hypothetical protein 95 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 CMS2_k127_3203927_27 379066.GAU_1887 1.977e-56 201.0 COG0669@1|root,COG0669@2|Bacteria,1ZTTQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like CMS2_k127_3203927_18 1379270.AUXF01000006_gene74 1.293e-84 290.0 COG0280@1|root,COG0280@2|Bacteria,1ZT01@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Phosphate acetyl/butaryl transferase - - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB CMS2_k127_3203927_31 861299.J421_3455 1.626e-40 152.0 COG1366@1|root,COG1366@2|Bacteria,1ZTXM@142182|Gemmatimonadetes 142182|Gemmatimonadetes T STAS domain - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS CMS2_k127_3203927_34 1123508.JH636443_gene5099 1.607e-21 100.0 COG2172@1|root,COG2172@2|Bacteria,2J0BZ@203682|Planctomycetes 203682|Planctomycetes T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 CMS2_k127_3203927_15 861299.J421_3453 1.527e-98 341.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1ZSPW@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE CMS2_k127_3203927_28 861299.J421_3452 5.856e-50 190.0 COG0030@1|root,COG0030@2|Bacteria,1ZT2M@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD CMS2_k127_3203927_21 379066.GAU_1881 4.719e-70 242.0 COG2344@1|root,COG2344@2|Bacteria,1ZTJV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N CMS2_k127_3203927_26 1379270.AUXF01000006_gene80 1.86e-56 208.0 COG0847@1|root,COG0847@2|Bacteria,1ZTNH@142182|Gemmatimonadetes 142182|Gemmatimonadetes L EXOIII - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T CMS2_k127_3203927_10 861299.J421_3449 1.096e-109 363.0 COG0491@1|root,COG0491@2|Bacteria,1ZT7V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B CMS2_k127_3203927_24 379066.GAU_1878 3.904e-67 233.0 COG0290@1|root,COG0290@2|Bacteria,1ZTM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N CMS2_k127_3203927_37 1120951.AUBG01000007_gene294 6.343e-15 76.0 COG0291@1|root,COG0291@2|Bacteria,4NUVR@976|Bacteroidetes,1I52P@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p CMS2_k127_3203927_30 861299.J421_3446 1.799e-44 164.0 COG0292@1|root,COG0292@2|Bacteria,1ZTUF@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 CMS2_k127_3203927_12 445972.ANACOL_03422 4.446e-103 346.0 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WGWV@541000|Ruminococcaceae 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d CMS2_k127_3203927_5 518766.Rmar_0618 1.167e-142 486.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,4NF5B@976|Bacteroidetes,1FIKR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Ferredoxin-fold anticodon binding domain pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind CMS2_k127_3203927_35 1379270.AUXF01000006_gene88 7.437e-21 98.0 COG3027@1|root,COG3027@2|Bacteria,1ZU4G@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA CMS2_k127_3203927_1 861299.J421_3441 7.277e-203 645.0 COG1418@1|root,COG1418@2|Bacteria,1ZT0I@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 CMS2_k127_3203927_11 1396141.BATP01000040_gene2073 1.112e-105 350.0 COG0190@1|root,COG0190@2|Bacteria,46TG7@74201|Verrucomicrobia,2ITSZ@203494|Verrucomicrobiae 203494|Verrucomicrobiae H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C CMS2_k127_3203927_14 379066.GAU_1869 8.549e-103 348.0 COG1570@1|root,COG1570@2|Bacteria,1ZT8T@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 CMS2_k127_3203927_41 768704.Desmer_1033 2.461e-05 49.0 COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,24UH5@186801|Clostridia,2634U@186807|Peptococcaceae 186801|Clostridia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S CMS2_k127_3203927_19 861299.J421_3437 3.772e-77 270.0 COG0142@1|root,COG0142@2|Bacteria,1ZSR3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Polyprenyl synthetase - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt CMS2_k127_3203927_0 379066.GAU_1866 1.746e-234 742.0 COG1154@1|root,COG1154@2|Bacteria,1ZSP2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C CMS2_k127_3203927_22 1379270.AUXF01000006_gene95 8.996e-70 248.0 COG0061@1|root,COG0061@2|Bacteria,1ZT32@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase CMS2_k127_3203927_3 861299.J421_3434 3.527e-148 487.0 COG0497@1|root,COG0497@2|Bacteria,1ZSV4@142182|Gemmatimonadetes 142182|Gemmatimonadetes L May be involved in recombinational repair of damaged DNA - - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N CMS2_k127_3203927_33 861299.J421_3433 1.111e-24 120.0 2C3N7@1|root,33YDV@2|Bacteria,1ZTRI@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3203927_20 518766.Rmar_0133 1.553e-71 259.0 COG2755@1|root,COG2755@2|Bacteria,4PM67@976|Bacteroidetes,1FJ25@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - - CMS2_k127_3203927_8 1089550.ATTH01000001_gene487 5.048e-116 389.0 COG2067@1|root,COG2067@2|Bacteria,4NFFF@976|Bacteroidetes,1FIPQ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X CMS2_k127_3203927_25 1125863.JAFN01000001_gene2630 2.505e-63 230.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - iAF987.Gmet_3470 CBS,Voltage_CLC CMS2_k127_3206339_21 309801.trd_0227 1.959e-28 118.0 COG2206@1|root,COG2206@2|Bacteria,2GAMR@200795|Chloroflexi,27XPB@189775|Thermomicrobia 189775|Thermomicrobia T HD domain - - - - - - - - - - - - HD_5 CMS2_k127_3206339_18 1429046.RR21198_4770 1.803e-33 151.0 COG3629@1|root,COG3629@2|Bacteria,2I2QB@201174|Actinobacteria,4FXSP@85025|Nocardiaceae 201174|Actinobacteria K transcriptional regulator, SARP family - - - - - - - - - - - - AAA_16,BTAD,Trans_reg_C CMS2_k127_3206339_3 861299.J421_3951 1.599e-133 433.0 COG0714@1|root,COG0714@2|Bacteria,1ZT5U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS2_k127_3206339_26 518766.Rmar_0309 1.001e-05 53.0 COG5336@1|root,COG5336@2|Bacteria 2|Bacteria C function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex atpI - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 CMS2_k127_3206339_9 861299.J421_3947 2.182e-63 228.0 COG0356@1|root,COG0356@2|Bacteria,1ZSQ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A CMS2_k127_3206339_25 1236514.BAKL01000034_gene2864 7.875e-15 79.0 COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,2FTSZ@200643|Bacteroidia,4ARQC@815|Bacteroidaceae 976|Bacteroidetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C CMS2_k127_3206339_20 861299.J421_3945 8.18e-29 122.0 COG0711@1|root,COG0711@2|Bacteria,1ZTPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B CMS2_k127_3206339_14 861299.J421_3944 4.047e-41 158.0 COG0712@1|root,COG0712@2|Bacteria,1ZTP8@142182|Gemmatimonadetes 142182|Gemmatimonadetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP CMS2_k127_3206339_6 869210.Marky_0691 3.676e-89 302.0 COG2084@1|root,COG2084@2|Bacteria,1WIBK@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I PFAM NAD binding domain of 6-phosphogluconate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 CMS2_k127_3206339_10 1379270.AUXF01000004_gene3149 3.347e-56 201.0 COG1704@1|root,COG1704@2|Bacteria,1ZTQE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA CMS2_k127_3206339_23 382464.ABSI01000011_gene2923 8.616e-24 113.0 COG1708@1|root,COG1708@2|Bacteria 2|Bacteria S nucleotidyltransferase activity ant1 - 2.7.7.47 ko:K00984,ko:K19279 - - - - ko00000,ko01000,ko01504 - - - DUF4111,NTP_transf_2,UPF0158 CMS2_k127_3206339_17 1379270.AUXF01000004_gene3151 1.337e-36 149.0 COG1512@1|root,COG1512@2|Bacteria,1ZT1H@142182|Gemmatimonadetes 142182|Gemmatimonadetes S TPM domain - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase CMS2_k127_3206339_19 247490.KSU1_B0018 1.956e-31 131.0 COG0437@1|root,COG0437@2|Bacteria,2J376@203682|Planctomycetes 203682|Planctomycetes C 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - CMS2_k127_3206339_13 378806.STAUR_4024 1.095e-42 158.0 COG0662@1|root,COG0662@2|Bacteria,1NADF@1224|Proteobacteria,4383M@68525|delta/epsilon subdivisions,2X9WE@28221|Deltaproteobacteria,2YVKF@29|Myxococcales 28221|Deltaproteobacteria G Mannose-6-phosphate isomerase - - - - - - - - - - - - Cupin_2 CMS2_k127_3206339_4 861299.J421_3942 2.411e-113 376.0 COG1208@1|root,COG1208@2|Bacteria,1ZSYR@142182|Gemmatimonadetes 142182|Gemmatimonadetes JM Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase CMS2_k127_3206339_15 1211815.CBYP010000030_gene1278 7.049e-40 157.0 COG0053@1|root,COG0053@2|Bacteria,2GQJJ@201174|Actinobacteria,4ERTV@85013|Frankiales 201174|Actinobacteria P Cation efflux family - - - - - - - - - - - - Cation_efflux CMS2_k127_3206339_2 661478.OP10G_1068 2.151e-145 471.0 COG1446@1|root,COG1446@2|Bacteria 2|Bacteria E asparaginase asnA2 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 ko:K01424,ko:K01444,ko:K13051 ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 - - - Asparaginase_2 CMS2_k127_3206339_7 457570.Nther_2188 4.646e-83 296.0 COG4805@1|root,COG4805@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 CMS2_k127_3206339_22 1121085.AUCI01000009_gene2986 7.041e-24 104.0 arCOG03655@1|root,32S6W@2|Bacteria,1VCVG@1239|Firmicutes,4HKHA@91061|Bacilli,1ZIIH@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - CMS2_k127_3206339_8 42256.RradSPS_2387 2.164e-80 278.0 COG0003@1|root,COG0003@2|Bacteria,2HG29@201174|Actinobacteria,4CTSC@84995|Rubrobacteria 84995|Rubrobacteria D Anion-transporting ATPase - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase CMS2_k127_3206339_1 649638.Trad_1018 1.185e-185 597.0 COG1966@1|root,COG1966@2|Bacteria,1WMNS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T 5TM C-terminal transporter carbon starvation CstA - - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM CMS2_k127_3206339_11 1379698.RBG1_1C00001G0906 5.406e-56 206.0 COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS2_k127_3206339_12 266117.Rxyl_0134 1.912e-51 193.0 COG1409@1|root,COG1409@2|Bacteria,2GU3Z@201174|Actinobacteria 201174|Actinobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 CMS2_k127_3206339_16 861299.J421_3935 3.992e-39 156.0 2C421@1|root,33VAH@2|Bacteria,1ZTQV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SprT-like family - - - - - - - - - - - - SprT-like CMS2_k127_3206339_0 861299.J421_3934 3.362e-189 597.0 COG1960@1|root,COG1960@2|Bacteria,1ZSVE@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS2_k127_3206339_24 290315.Clim_0730 5.229e-20 92.0 COG2261@1|root,COG2261@2|Bacteria 2|Bacteria S Transglycosylase associated protein - - - - - - - - - - - - Transgly_assoc CMS2_k127_3206339_5 927677.ALVU02000001_gene3047 4.088e-107 362.0 COG0477@1|root,COG2814@2|Bacteria,1G2Z0@1117|Cyanobacteria 1117|Cyanobacteria EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr CMS2_k127_3206339_27 42254.XP_004621538.1 0.0008316 44.0 28M73@1|root,2QTQ3@2759|Eukaryota,39RFK@33154|Opisthokonta,3BEUV@33208|Metazoa,3CRGA@33213|Bilateria,4860Q@7711|Chordata,492NJ@7742|Vertebrata,3JD5J@40674|Mammalia 33208|Metazoa S Neuroblast differentiation-associated protein AHNAK AHNAK GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0008150,GO:0009987,GO:0010468,GO:0010959,GO:0015629,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0022607,GO:0022898,GO:0030016,GO:0030054,GO:0030315,GO:0031323,GO:0031982,GO:0032409,GO:0032412,GO:0032879,GO:0034762,GO:0034765,GO:0042383,GO:0043034,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043230,GO:0043231,GO:0043232,GO:0043269,GO:0043292,GO:0043484,GO:0043933,GO:0044085,GO:0044291,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044444,GO:0044449,GO:0044459,GO:0044464,GO:0044548,GO:0050789,GO:0050794,GO:0051049,GO:0051171,GO:0051252,GO:0051259,GO:0051924,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070062,GO:0071840,GO:0071944,GO:0080090,GO:0097493,GO:0099080,GO:0099081,GO:0099512,GO:1901019,GO:1901385,GO:1903169,GO:1903561,GO:1904062,GO:2001257 - - - - - - - - - - - CMS2_k127_3262703_0 1047013.AQSP01000059_gene2095 1.155e-213 676.0 COG1757@1|root,COG1757@2|Bacteria,2NRD3@2323|unclassified Bacteria 2|Bacteria C Na+/H+ antiporter family nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter CMS2_k127_3262703_11 1116232.AHBF01000135_gene1985 2.591e-05 50.0 COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria 201174|Actinobacteria U Type IV secretory pathway, VirB4 - - - - - - - - - - - - - CMS2_k127_3262703_4 1185876.BN8_04256 7.737e-94 329.0 COG0296@1|root,COG1680@1|root,COG0296@2|Bacteria,COG1680@2|Bacteria,4NG6Z@976|Bacteroidetes,47PR8@768503|Cytophagia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - AMPK1_CBM,Beta-lactamase CMS2_k127_3262703_8 1047013.AQSP01000049_gene2263 6.532e-20 94.0 COG0399@1|root,COG0399@2|Bacteria 2|Bacteria E UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1,Y2_Tnp,Zn_Tnp_IS91 CMS2_k127_3262703_1 1510531.JQJJ01000010_gene2050 5.922e-179 575.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,3JQP1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Domain of unknown function (DUF4070) MA20_17485 - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM CMS2_k127_3262703_6 234267.Acid_3938 2.823e-36 148.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS2_k127_3262703_2 1267535.KB906767_gene3695 7.957e-162 547.0 COG0577@1|root,COG0577@2|Bacteria,3Y38T@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_3262703_7 1278073.MYSTI_07863 1.192e-31 127.0 COG1695@1|root,COG1695@2|Bacteria,1PMEN@1224|Proteobacteria,43544@68525|delta/epsilon subdivisions,2WZF7@28221|Deltaproteobacteria,2Z209@29|Myxococcales 28221|Deltaproteobacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_3262703_3 861299.J421_5949 3.25e-121 423.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5949|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_3262703_12 861299.J421_1230 0.0001275 51.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_3262703_9 1038869.AXAN01000040_gene3397 2.59e-19 92.0 COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,2WA57@28216|Betaproteobacteria,1K26A@119060|Burkholderiaceae 28216|Betaproteobacteria P Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_11 CMS2_k127_3262703_5 1379270.AUXF01000001_gene1880 5.437e-88 321.0 COG0823@1|root,COG3629@1|root,COG0823@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS2_k127_3270041_12 861299.J421_1666 6.838e-80 293.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_3270041_22 1127696.HMPREF9134_01541 7.473e-08 62.0 COG2067@1|root,COG2067@2|Bacteria,4NVVD@976|Bacteroidetes,2FQRB@200643|Bacteroidia,23101@171551|Porphyromonadaceae 976|Bacteroidetes I long-chain fatty acid transport protein - - - - - - - - - - - - OMP_b-brl CMS2_k127_3270041_26 760568.Desku_0820 0.0009232 49.0 COG2314@1|root,COG2314@2|Bacteria,1VESS@1239|Firmicutes,24TIB@186801|Clostridia 186801|Clostridia S TM2 domain - - - - - - - - - - - - - CMS2_k127_3270041_13 1191523.MROS_0663 5.734e-78 274.0 COG3358@1|root,COG3358@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1684) - - - ko:K09164 - - - - ko00000 - - - DUF1684 CMS2_k127_3270041_25 322710.Avin_01580 0.0001425 47.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,1RQCV@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE CMS2_k127_3270041_23 1122975.AQVC01000003_gene1319 1.018e-05 53.0 COG4774@1|root,COG4774@2|Bacteria,4PKNF@976|Bacteroidetes,2G0UR@200643|Bacteroidia,23258@171551|Porphyromonadaceae 976|Bacteroidetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_3270041_7 1192034.CAP_8837 1.598e-122 404.0 COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,4304Z@68525|delta/epsilon subdivisions,2WVJ8@28221|Deltaproteobacteria,2YV3F@29|Myxococcales 28221|Deltaproteobacteria L Eukaryotic DNA topoisomerase I, catalytic core topI - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_I CMS2_k127_3270041_0 391587.KAOT1_14757 1.691e-285 892.0 COG0339@1|root,COG0339@2|Bacteria,4NFYA@976|Bacteroidetes,1HY0G@117743|Flavobacteriia 976|Bacteroidetes E Peptidase family M3 - - 3.4.15.5 ko:K01284 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 CMS2_k127_3270041_14 886293.Sinac_0214 1.535e-77 276.0 COG3119@1|root,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes 203682|Planctomycetes P arylsulfatase A - - - - - - - - - - - - Sulfatase,TPR_16,TPR_19,TPR_2 CMS2_k127_3270041_3 886293.Sinac_1691 4.577e-238 751.0 COG3379@1|root,COG3379@2|Bacteria,2IXA8@203682|Planctomycetes 203682|Planctomycetes S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest CMS2_k127_3270041_2 886293.Sinac_2688 1.291e-238 746.0 COG3379@1|root,COG3379@2|Bacteria,2IYF3@203682|Planctomycetes 2|Bacteria P Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest CMS2_k127_3270041_4 861299.J421_1386 1.781e-179 574.0 COG1473@1|root,COG1473@2|Bacteria,1ZUAX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer CMS2_k127_3270041_21 1379270.AUXF01000001_gene2088 2.993e-16 83.0 2DDI2@1|root,2ZI6I@2|Bacteria,1ZVAF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3270041_6 234267.Acid_2224 1.825e-142 462.0 COG0624@1|root,COG0624@2|Bacteria,3Y7TX@57723|Acidobacteria 57723|Acidobacteria E Peptidase family M20/M25/M40 - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS2_k127_3270041_11 379066.GAU_3347 1.292e-90 309.0 COG2362@1|root,COG2362@2|Bacteria 2|Bacteria E D-aminopeptidase dppA - - ko:K16203 - - - - ko00000,ko01000,ko01002 3.A.1.5.2 - - Peptidase_M55 CMS2_k127_3270041_5 861299.J421_6081 5.747e-158 507.0 COG4948@1|root,COG4948@2|Bacteria,1ZUQN@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) - - 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N CMS2_k127_3270041_16 861299.J421_6082 2.886e-61 221.0 COG3375@1|root,COG3375@2|Bacteria,1ZUBU@142182|Gemmatimonadetes 142182|Gemmatimonadetes M carboxylic acid catabolic process - - - - - - - - - - - - - CMS2_k127_3270041_8 1047013.AQSP01000100_gene588 4.545e-113 385.0 COG3949@1|root,COG3949@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_3270041_10 643648.Slip_1683 2.199e-96 326.0 COG0031@1|root,COG0031@2|Bacteria,1UV8X@1239|Firmicutes,258FH@186801|Clostridia,42KFI@68298|Syntrophomonadaceae 186801|Clostridia H Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_3270041_20 861299.J421_2449 1.866e-25 122.0 COG1413@1|root,COG1413@2|Bacteria,1ZTWT@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS2_k127_3270041_17 861299.J421_1595 3.701e-55 204.0 COG2199@1|root,COG2199@2|Bacteria 2|Bacteria T diguanylate cyclase activity yeaP GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621 2.7.7.65 ko:K13069 - - R08057 - ko00000,ko01000 - - - GAF,GAF_2,GAF_3,GGDEF CMS2_k127_3270041_19 382464.ABSI01000023_gene576 5.486e-27 121.0 COG0287@1|root,COG0287@2|Bacteria,46SSN@74201|Verrucomicrobia,2IU8S@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH CMS2_k127_3270041_9 33035.JPJF01000016_gene3918 7.626e-99 337.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3XZCI@572511|Blautia 186801|Clostridia E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase CMS2_k127_3270041_18 591001.Acfer_1241 2.359e-43 168.0 COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,4H4MX@909932|Negativicutes 909932|Negativicutes F Belongs to the cytidylate kinase family. Type 1 subfamily cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin CMS2_k127_3270041_1 861299.J421_3420 1.267e-272 853.0 COG0539@1|root,COG0539@2|Bacteria,1ZSKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 CMS2_k127_3270041_15 760142.Hipma_0823 8.957e-64 221.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2M6AK@213113|Desulfurellales 28221|Deltaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans CMS2_k127_3284005_4 944481.JAFP01000001_gene95 5.387e-22 97.0 COG1598@1|root,COG1598@2|Bacteria,1QSXW@1224|Proteobacteria,42X4E@68525|delta/epsilon subdivisions 1224|Proteobacteria S HicB_like antitoxin of bacterial toxin-antitoxin system - - - - - - - - - - - - HicB_lk_antitox CMS2_k127_3284005_1 1088721.NSU_1615 1.033e-65 231.0 COG1432@1|root,COG1432@2|Bacteria,1RJ15@1224|Proteobacteria,2UCYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S NYN domain - - - - - - - - - - - - NYN CMS2_k127_3284005_2 861299.J421_1545 7.136e-51 206.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS2_k127_3284005_6 1379270.AUXF01000001_gene2088 2.188e-06 56.0 2DDI2@1|root,2ZI6I@2|Bacteria,1ZVAF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3284005_0 448385.sce2877 9.896e-86 299.0 COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin CMS2_k127_3284005_5 1122134.KB893650_gene1298 4.95e-10 72.0 2FBD5@1|root,343IZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_3284005_3 1379270.AUXF01000007_gene994 4.146e-48 175.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_3328442_11 986075.CathTA2_1817 8.293e-19 97.0 COG1030@1|root,COG1030@2|Bacteria,1TR54@1239|Firmicutes,4H9P9@91061|Bacilli 91061|Bacilli O COG1030 Membrane-bound serine protease (ClpP class) yqeZ - - ko:K07403 - - - - ko00000 - - - NfeD,SDH_sah CMS2_k127_3328442_4 1047013.AQSP01000120_gene937 8.873e-173 549.0 COG4030@1|root,COG4030@2|Bacteria 2|Bacteria M Protein of unknown function (DUF2961) - - - - - - - - - - - - DUF2961 CMS2_k127_3328442_10 643648.Slip_1894 1.968e-45 170.0 28JE3@1|root,2Z98B@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - AbiEii CMS2_k127_3328442_1 926550.CLDAP_22510 2.306e-242 760.0 COG0488@1|root,COG0488@2|Bacteria 2|Bacteria L (ABC) transporter yjjK GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn CMS2_k127_3328442_7 379066.GAU_2993 1.716e-120 400.0 COG1408@1|root,COG1408@2|Bacteria,1ZV9S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos CMS2_k127_3328442_0 313595.P700755_000672 0.0 1289.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1HYJJ@117743|Flavobacteriia 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ CMS2_k127_3328442_3 234267.Acid_7084 6.634e-185 585.0 COG0524@1|root,COG0524@2|Bacteria,3Y3DE@57723|Acidobacteria 57723|Acidobacteria G PfkB domain protein - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB CMS2_k127_3328442_5 1128421.JAGA01000002_gene1496 1.448e-149 484.0 COG3875@1|root,COG3875@2|Bacteria 2|Bacteria S lactate racemase activity - - 5.1.2.1 ko:K22373 ko00620,map00620 - R01450 RC00519 ko00000,ko00001,ko01000 - - - DUF2088 CMS2_k127_3328442_2 521098.Aaci_1061 1.54e-190 605.0 COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,4H9NC@91061|Bacilli 91061|Bacilli G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 CMS2_k127_3328442_6 595460.RRSWK_06850 6.088e-136 449.0 COG0524@1|root,COG0524@2|Bacteria,2IWUH@203682|Planctomycetes 203682|Planctomycetes G pfkB family carbohydrate kinase - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB CMS2_k127_3328442_8 1396418.BATQ01000027_gene5243 1.765e-74 256.0 COG0800@1|root,COG0800@2|Bacteria,46V7J@74201|Verrucomicrobia,2IU9V@203494|Verrucomicrobiae 203494|Verrucomicrobiae G KDPG and KHG aldolase - - - - - - - - - - - - Aldolase CMS2_k127_3328442_9 861299.J421_5597 5.506e-66 236.0 COG2152@1|root,COG2152@2|Bacteria 2|Bacteria G transferase activity, transferring glycosyl groups - - - - - - - - - - - - DUF1080 CMS2_k127_3335388_30 1379270.AUXF01000003_gene3388 2.07e-23 106.0 COG4968@1|root,COG4968@2|Bacteria,1ZUZK@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl CMS2_k127_3335388_2 379066.GAU_2525 3.885e-198 629.0 COG2204@1|root,COG2204@2|Bacteria,1ZSRQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_3335388_12 1379270.AUXF01000003_gene3385 1.055e-119 405.0 COG3852@1|root,COG3852@2|Bacteria,1ZSYP@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PAS domain - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA CMS2_k127_3335388_9 1379270.AUXF01000001_gene2826 1.878e-167 534.0 COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Type II secretion system (T2SS), protein F - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF CMS2_k127_3335388_4 379066.GAU_2569 8.509e-182 574.0 COG2805@1|root,COG2805@2|Bacteria,1ZSQE@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS2_k127_3335388_3 639282.DEFDS_1109 1.005e-192 617.0 COG2804@1|root,COG2804@2|Bacteria,2GEP7@200930|Deferribacteres 200930|Deferribacteres NU General secretory system II protein E domain protein - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N CMS2_k127_3335388_32 688269.Theth_0083 2.181e-18 93.0 COG1555@1|root,COG1555@2|Bacteria,2GD8U@200918|Thermotogae 200918|Thermotogae L TIGRFAM competence protein ComEA helix-hairpin-helix repeat - - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 CMS2_k127_3335388_20 880073.Calab_0186 3.083e-66 236.0 COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria 2|Bacteria S Peptidase M28 ywaD - - - - - - - - - - - Peptidase_M28 CMS2_k127_3335388_0 1379270.AUXF01000001_gene2822 7.336e-308 1019.0 COG4797@1|root,COG4797@2|Bacteria 2|Bacteria - - - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259 - - - - - - - - - - Glyco_transf_41,MethyTransf_Reg,Methyltransf_12,Methyltransf_25,Methyltransf_31 CMS2_k127_3335388_15 861299.J421_4162 7.482e-83 294.0 COG0795@1|root,COG0795@2|Bacteria,1ZTJR@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Predicted permease YjgP/YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ CMS2_k127_3335388_14 861299.J421_4163 6.331e-87 305.0 COG0795@1|root,COG0795@2|Bacteria,1ZSNM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Predicted permease YjgP/YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ CMS2_k127_3335388_6 1047013.AQSP01000133_gene2117 2.677e-177 567.0 COG1757@1|root,COG1757@2|Bacteria,2NPD8@2323|unclassified Bacteria 2|Bacteria C Na+/H+ antiporter family mleN - - - - - - - - - - - Na_H_antiporter CMS2_k127_3335388_26 861299.J421_4171 1.668e-41 165.0 COG1612@1|root,COG1612@2|Bacteria,1ZURE@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome oxidase assembly protein - - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA CMS2_k127_3335388_13 861299.J421_4178 8.655e-107 358.0 COG0006@1|root,COG0006@2|Bacteria,1ZSPF@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Metallopeptidase family M24 - - - - - - - - - - - - Peptidase_M24 CMS2_k127_3335388_31 379066.GAU_2585 2.356e-20 98.0 2C9AX@1|root,33WUH@2|Bacteria,1ZTQK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3335388_22 1379270.AUXF01000001_gene2568 8.89e-49 180.0 COG1595@1|root,COG1595@2|Bacteria,1ZV3I@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_3335388_37 743718.Isova_2336 4.289e-09 63.0 COG5662@1|root,COG5662@2|Bacteria,2I0MN@201174|Actinobacteria,4F4TV@85017|Promicromonosporaceae 201174|Actinobacteria K Putative zinc-finger - - - - - - - - - - - - zf-HC2 CMS2_k127_3335388_35 479434.Sthe_2767 7.772e-16 87.0 COG1836@1|root,COG1836@2|Bacteria,2G6N3@200795|Chloroflexi,27YMI@189775|Thermomicrobia 189775|Thermomicrobia S Integral membrane protein DUF92 - - - - - - - - - - - - DUF92 CMS2_k127_3335388_18 861299.J421_4190 1.135e-73 254.0 COG0755@1|root,COG0755@2|Bacteria,1ZTJG@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome C assembly protein - - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm CMS2_k127_3335388_19 861299.J421_4191 5.475e-68 238.0 COG2386@1|root,COG2386@2|Bacteria,1ZTJ6@142182|Gemmatimonadetes 142182|Gemmatimonadetes O CcmB protein - - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB CMS2_k127_3335388_23 1125863.JAFN01000001_gene3012 7.042e-47 177.0 COG1131@1|root,COG1131@2|Bacteria,1RGM1@1224|Proteobacteria,43ADE@68525|delta/epsilon subdivisions,2X5TA@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran CMS2_k127_3335388_39 1173264.KI913949_gene713 4.518e-06 54.0 COG1366@1|root,COG1366@2|Bacteria,1G7NW@1117|Cyanobacteria,1HCQQ@1150|Oscillatoriales 1117|Cyanobacteria T Belongs to the anti-sigma-factor antagonist family - - - - - - - - - - - - STAS CMS2_k127_3335388_34 316274.Haur_0611 5.855e-17 86.0 COG4243@1|root,COG4243@2|Bacteria,2G9QC@200795|Chloroflexi,3764Y@32061|Chloroflexia 32061|Chloroflexia CO PFAM Vitamin K epoxide reductase - - - - - - - - - - - - VKOR CMS2_k127_3335388_25 861299.J421_4198 7.793e-42 164.0 COG1651@1|root,COG1651@2|Bacteria,1ZTKP@142182|Gemmatimonadetes 142182|Gemmatimonadetes O DSBA-like thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 CMS2_k127_3335388_36 861299.J421_4201 8.505e-15 77.0 2CA00@1|root,344QM@2|Bacteria,1ZU1Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3335388_29 1423321.AS29_17420 4.918e-24 108.0 COG1765@1|root,COG1765@2|Bacteria,1V78R@1239|Firmicutes,4HMM3@91061|Bacilli,1ZH2T@1386|Bacillus 91061|Bacilli O OsmC-like protein - - - - - - - - - - - - OsmC CMS2_k127_3335388_41 338963.Pcar_0547 0.0002417 50.0 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1R4WG@1224|Proteobacteria,43AIM@68525|delta/epsilon subdivisions,2X5YU@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 CMS2_k127_3335388_38 319225.Plut_0448 4.757e-07 61.0 COG0558@1|root,COG0558@2|Bacteria,1FDVM@1090|Chlorobi 1090|Chlorobi I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf CMS2_k127_3335388_27 215803.DB30_7168 6.59e-37 146.0 COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42UGQ@68525|delta/epsilon subdivisions,2WQY8@28221|Deltaproteobacteria,2YVI9@29|Myxococcales 28221|Deltaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding CMS2_k127_3335388_8 861299.J421_4207 1.476e-170 567.0 COG0612@1|root,COG0612@2|Bacteria,1ZSU0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_3335388_11 861299.J421_4211 1.264e-127 419.0 COG0457@1|root,COG0457@2|Bacteria,1ZSYB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2 CMS2_k127_3335388_5 1305737.JAFX01000001_gene2703 9.098e-178 569.0 COG2234@1|root,COG2234@2|Bacteria,4NENF@976|Bacteroidetes,47TEC@768503|Cytophagia 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28,fn3 CMS2_k127_3335388_10 1254432.SCE1572_09530 2.755e-136 446.0 COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,43AQN@68525|delta/epsilon subdivisions,2X64N@28221|Deltaproteobacteria,2Z2K7@29|Myxococcales 28221|Deltaproteobacteria EGP Sugar (and other) transporter - - - ko:K08178 - - - - ko00000,ko02000 2.A.1.12 - - MFS_1 CMS2_k127_3335388_16 1379270.AUXF01000002_gene1600 7.638e-78 270.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_3335388_17 1379270.AUXF01000002_gene1600 4.483e-74 261.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_3335388_1 1267535.KB906767_gene3695 9.109e-202 659.0 COG0577@1|root,COG0577@2|Bacteria,3Y38T@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_3335388_24 1267535.KB906767_gene3694 1.417e-45 166.0 COG1695@1|root,COG1695@2|Bacteria,3Y5BK@57723|Acidobacteria 57723|Acidobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR CMS2_k127_3335388_7 1183438.GKIL_4354 7.663e-172 571.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_3335388_28 1267533.KB906734_gene4016 2.606e-26 112.0 COG1695@1|root,COG1695@2|Bacteria,3Y8CC@57723|Acidobacteria,2JP3G@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_3335388_21 1121930.AQXG01000015_gene1861 9.473e-59 209.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug CMS2_k127_3337515_18 935948.KE386494_gene944 9.653e-95 325.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales 186801|Clostridia E PFAM aminotransferase, class I - - - - - - - - - - - - Aminotran_1_2 CMS2_k127_3337515_0 485915.Dret_1750 1.025e-266 842.0 COG0021@1|root,COG0021@2|Bacteria 2|Bacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_N,XFP,XFP_N CMS2_k127_3337515_8 1121324.CLIT_13c01190 5.093e-140 458.0 COG1114@1|root,COG1114@2|Bacteria,1TQIS@1239|Firmicutes,248I0@186801|Clostridia 186801|Clostridia E Component of the transport system for branched-chain amino acids - - - ko:K03311 - - - - ko00000 2.A.26 - - Branch_AA_trans CMS2_k127_3337515_12 518766.Rmar_0138 7.108e-119 397.0 COG0168@1|root,COG0168@2|Bacteria,4NF7R@976|Bacteroidetes,1FIT8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Cation transport protein - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH CMS2_k127_3337515_21 1089550.ATTH01000001_gene1674 2.622e-63 224.0 COG0569@1|root,COG0569@2|Bacteria,4NGRQ@976|Bacteroidetes,1FJ8V@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C TrkA-N domain ktrA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N CMS2_k127_3337515_24 1047013.AQSP01000130_gene1872 2.845e-55 202.0 COG0730@1|root,COG0730@2|Bacteria,2NP64@2323|unclassified Bacteria 2|Bacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE CMS2_k127_3337515_19 716544.wcw_0937 4.584e-80 272.0 COG0491@1|root,COG0491@2|Bacteria,2JGPW@204428|Chlamydiae 204428|Chlamydiae S Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family - - - - - - - - - - - - Lactamase_B CMS2_k127_3337515_7 861299.J421_0279 5.807e-144 489.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_0279|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_3337515_28 861299.J421_6344 6.087e-35 137.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_3337515_5 1267535.KB906767_gene3267 3.957e-157 507.0 COG2239@1|root,COG2239@2|Bacteria,3Y7A9@57723|Acidobacteria 57723|Acidobacteria P Divalent cation transporter - - - - - - - - - - - - CBS,MgtE,MgtE_N CMS2_k127_3337515_1 661478.OP10G_1529 2.425e-202 646.0 COG4805@1|root,COG4805@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 CMS2_k127_3337515_4 566466.NOR53_2236 5.072e-161 522.0 COG2843@1|root,COG2843@2|Bacteria 2|Bacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap CMS2_k127_3337515_23 1519464.HY22_11785 2.05e-60 230.0 COG2866@1|root,COG2866@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity - - - - - - - - - - - - Peptidase_M14 CMS2_k127_3337515_29 706587.Desti_3262 8.455e-33 133.0 COG2721@1|root,COG2721@2|Bacteria,1MZBN@1224|Proteobacteria,430WP@68525|delta/epsilon subdivisions,2WVKH@28221|Deltaproteobacteria 28221|Deltaproteobacteria G SAF domain - - 4.4.1.24 ko:K16845 ko00270,map00270 - R07633 RC01785 ko00000,ko00001,ko01000 - - - SAF CMS2_k127_3337515_2 706587.Desti_3263 2.168e-200 630.0 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,42QDM@68525|delta/epsilon subdivisions,2WIZM@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM D-galactarate dehydratase Altronate hydrolase - - 4.4.1.24 ko:K16846 ko00270,map00270 - R07633 RC01785 ko00000,ko00001,ko01000 - - - GD_AH_C CMS2_k127_3337515_6 204669.Acid345_2395 8.378e-157 519.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K08282,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16,TPR_2,TPR_8 CMS2_k127_3337515_13 340099.Teth39_0432 6.451e-116 390.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,42FA0@68295|Thermoanaerobacterales 186801|Clostridia E amino acid carrier protein agcS - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp CMS2_k127_3337515_11 439235.Dalk_1418 4.024e-121 404.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MNI@68525|delta/epsilon subdivisions,2WJMV@28221|Deltaproteobacteria,2MIU0@213118|Desulfobacterales 28221|Deltaproteobacteria KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat CMS2_k127_3337515_14 1379698.RBG1_1C00001G0696 2.257e-115 386.0 COG1301@1|root,COG1301@2|Bacteria,2NP6X@2323|unclassified Bacteria 2|Bacteria U Sodium:dicarboxylate symporter family gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF CMS2_k127_3337515_16 765952.PUV_00830 4.908e-108 361.0 COG0861@1|root,COG0861@2|Bacteria,2JGY6@204428|Chlamydiae 204428|Chlamydiae P Integral membrane protein TerC family - - - ko:K05794 - - - - ko00000 - - - TerC CMS2_k127_3337515_31 305700.B447_15236 4.303e-28 125.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VQY7@28216|Betaproteobacteria,2KYP5@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 CMS2_k127_3337515_27 234267.Acid_3187 2.201e-41 161.0 COG1392@1|root,COG1392@2|Bacteria,3Y58U@57723|Acidobacteria 57723|Acidobacteria P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div CMS2_k127_3337515_10 1340493.JNIF01000003_gene1743 2.21e-129 421.0 COG0306@1|root,COG0306@2|Bacteria,3Y3ZW@57723|Acidobacteria 57723|Acidobacteria P PFAM phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 CMS2_k127_3337515_30 330214.NIDE4157 2.048e-29 122.0 COG3824@1|root,COG3824@2|Bacteria 2|Bacteria S Zincin-like metallopeptidase - - - - - - - - - - - - Zincin_1 CMS2_k127_3337515_9 102125.Xen7305DRAFT_00033680 6.673e-130 423.0 COG0306@1|root,COG0306@2|Bacteria 2|Bacteria P phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 CMS2_k127_3337515_26 459495.SPLC1_S201500 3.801e-43 171.0 COG1392@1|root,COG1392@2|Bacteria,1G5NA@1117|Cyanobacteria 1117|Cyanobacteria P Phosphate transport regulator - - - ko:K07220 - - - - ko00000 - - - PhoU_div CMS2_k127_3337515_32 439235.Dalk_1609 1.842e-21 100.0 2E8UW@1|root,3335A@2|Bacteria,1N8I8@1224|Proteobacteria,42TGA@68525|delta/epsilon subdivisions,2WQAG@28221|Deltaproteobacteria,2MKHK@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3337515_20 1232410.KI421424_gene1592 5.744e-72 255.0 COG1215@1|root,COG2344@1|root,COG1215@2|Bacteria,COG2344@2|Bacteria,1R988@1224|Proteobacteria,42QKI@68525|delta/epsilon subdivisions,2WM6J@28221|Deltaproteobacteria,43S6T@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 CMS2_k127_3337515_25 1242864.D187_009865 1.257e-45 174.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42MBJ@68525|delta/epsilon subdivisions,2WNWX@28221|Deltaproteobacteria,2YZPF@29|Myxococcales 28221|Deltaproteobacteria M Transglycosylase mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly CMS2_k127_3337515_15 314345.SPV1_13177 2.759e-114 379.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria 1224|Proteobacteria M mechanosensitive ion channel ynaI - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel CMS2_k127_3337515_22 1379270.AUXF01000002_gene1600 2.195e-62 227.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_3337515_3 1238182.C882_0345 3.059e-168 534.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSBB@28211|Alphaproteobacteria,2JR85@204441|Rhodospirillales 204441|Rhodospirillales CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.83,1.1.1.93,4.1.1.73 ko:K07246 ko00630,ko00650,map00630,map00650 - R00215,R01751,R02545,R06180 RC00084,RC00105,RC00594 ko00000,ko00001,ko01000 - - - Iso_dh CMS2_k127_3337515_17 234267.Acid_6721 8.081e-103 354.0 COG1228@1|root,COG1228@2|Bacteria,3Y6JN@57723|Acidobacteria 57723|Acidobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS2_k127_3344739_14 379066.GAU_2497 1.099e-30 132.0 2C0MY@1|root,30KW5@2|Bacteria,1ZTVN@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3344739_15 596151.DesfrDRAFT_0706 1.118e-30 139.0 COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43D68@68525|delta/epsilon subdivisions,2X8CY@28221|Deltaproteobacteria,2MHGD@213115|Desulfovibrionales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF CMS2_k127_3344739_20 861299.J421_2665 9.335e-17 90.0 COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG1629@2|Bacteria,1ZTMF@142182|Gemmatimonadetes 142182|Gemmatimonadetes MP Gram-negative bacterial TonB protein C-terminal - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_C CMS2_k127_3344739_11 861299.J421_1752 3.212e-56 219.0 2DWGD@1|root,3407S@2|Bacteria,1ZV24@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg CMS2_k127_3344739_2 861299.J421_3955 1.132e-168 545.0 COG2204@1|root,COG2204@2|Bacteria,1ZSWY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat CMS2_k127_3344739_12 861299.J421_3956 1.526e-45 171.0 COG0521@1|root,COG0521@2|Bacteria,1ZU2Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Probable molybdopterin binding domain - - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth CMS2_k127_3344739_8 861299.J421_3957 5.486e-128 420.0 COG0404@1|root,COG0404@2|Bacteria,1ZTBZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C CMS2_k127_3344739_6 861299.J421_3960 7.756e-134 432.0 COG0078@1|root,COG0078@2|Bacteria,1ZT4K@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline - - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS2_k127_3344739_1 861299.J421_3962 1.275e-181 582.0 COG1220@1|root,COG1220@2|Bacteria,1ZSVP@142182|Gemmatimonadetes 142182|Gemmatimonadetes O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small CMS2_k127_3344739_10 861299.J421_3964 1.475e-71 246.0 COG5405@1|root,COG5405@2|Bacteria,1ZSVH@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome CMS2_k127_3344739_9 861299.J421_3967 1.5e-98 330.0 COG4974@1|root,COG4974@2|Bacteria,1ZT3T@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Phage integrase, N-terminal SAM-like domain xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase CMS2_k127_3344739_3 1379270.AUXF01000003_gene3404 1.109e-167 537.0 COG1206@1|root,COG1206@2|Bacteria,1ZTB8@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs gid - 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA CMS2_k127_3344739_0 96561.Dole_2445 2.401e-215 693.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MITA@213118|Desulfobacterales 28221|Deltaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom CMS2_k127_3344739_17 861299.J421_3973 3.488e-28 121.0 COG0703@1|root,COG0703@2|Bacteria,1ZTXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI CMS2_k127_3344739_4 861299.J421_3974 9.929e-151 486.0 COG0082@1|root,COG0082@2|Bacteria,1ZT39@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt CMS2_k127_3344739_5 861299.J421_3976 1.978e-137 458.0 COG4796@1|root,COG4796@2|Bacteria,1ZSRT@142182|Gemmatimonadetes 142182|Gemmatimonadetes U AMIN domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,Secretin,Secretin_N CMS2_k127_3344739_19 379066.GAU_2515 5.16e-18 91.0 2F6AC@1|root,33YU1@2|Bacteria,1ZTY6@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3344739_18 1379270.AUXF01000003_gene3396 5.277e-20 97.0 COG3167@1|root,COG3167@2|Bacteria,1ZTZ8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Pilus assembly protein, PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO CMS2_k127_3344739_13 1379270.AUXF01000003_gene3395 7.301e-31 130.0 COG3166@1|root,COG3166@2|Bacteria,1ZTR8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Fimbrial assembly protein (PilN) - - - - - - - - - - - - PilN CMS2_k127_3344739_7 1379270.AUXF01000003_gene3394 5.313e-132 429.0 COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type IV pilus assembly protein PilM; - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 CMS2_k127_3344739_16 1379270.AUXF01000002_gene1794 1.814e-30 134.0 2F0M3@1|root,33TPR@2|Bacteria,1ZUAZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3344739_21 379066.GAU_2520 2.944e-09 68.0 2A2CT@1|root,30QPT@2|Bacteria,1ZUZZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_3347126_2 269799.Gmet_0138 2.796e-140 460.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales 28221|Deltaproteobacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139,DUF4140 CMS2_k127_3347126_5 530564.Psta_2352 4.84e-33 133.0 COG4276@1|root,COG4276@2|Bacteria,2J0FI@203682|Planctomycetes 203682|Planctomycetes S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc CMS2_k127_3347126_1 314230.DSM3645_25517 1.149e-169 549.0 COG0415@1|root,COG0415@2|Bacteria,2IXWI@203682|Planctomycetes 203682|Planctomycetes L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase CMS2_k127_3347126_3 452637.Oter_1107 2.821e-63 229.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,46V45@74201|Verrucomicrobia 74201|Verrucomicrobia K helix_turn_helix, mercury resistance - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 CMS2_k127_3347126_4 1238450.VIBNISOn1_1530023 1.508e-56 201.0 COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,1RSMY@1236|Gammaproteobacteria,1XXKV@135623|Vibrionales 135623|Vibrionales M Secreted and surface protein containing fasciclin-like repeats - - - - - - - - - - - - Fasciclin CMS2_k127_3347126_0 1123242.JH636434_gene5621 8.749e-187 597.0 COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 CMS2_k127_3347126_6 1227360.C176_20729 1.078e-09 61.0 COG0492@1|root,COG0492@2|Bacteria,1TQGS@1239|Firmicutes,4HBIS@91061|Bacilli,26E40@186818|Planococcaceae 91061|Bacilli O Thioredoxin reductase ypdA - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_3 CMS2_k127_3356569_7 861299.J421_1545 3.303e-48 188.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS2_k127_3356569_6 1047013.AQSP01000142_gene173 2.641e-61 230.0 COG0793@1|root,COG2976@1|root,COG0793@2|Bacteria,COG2976@2|Bacteria 2|Bacteria CO Protein conserved in bacteria pflA - 3.4.21.102 ko:K03797,ko:K15539 - - - - ko00000,ko01000,ko01002 - - - DUF4012,Peptidase_S41,Peptidase_S41_N,TPR_16,TPR_21,TPR_6,TPR_8 CMS2_k127_3356569_14 639030.JHVA01000001_gene1214 4.159e-11 68.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia 2|Bacteria KLT Tetratricopeptide repeats - - 2.7.11.1 ko:K08282,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16,TPR_2,TPR_8 CMS2_k127_3356569_1 1173027.Mic7113_5585 1.113e-170 550.0 COG1252@1|root,COG1252@2|Bacteria,1G20T@1117|Cyanobacteria,1H80B@1150|Oscillatoriales 1117|Cyanobacteria C NADH dehydrogenase, FAD-containing subunit ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS2_k127_3356569_0 404589.Anae109_3191 2.4e-204 649.0 COG1719@1|root,COG3829@1|root,COG1719@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M2E@68525|delta/epsilon subdivisions,2WKAB@28221|Deltaproteobacteria,2YWDZ@29|Myxococcales 28221|Deltaproteobacteria K Transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat,V4R,XylR_N CMS2_k127_3356569_4 903818.KI912269_gene310 3.252e-143 484.0 COG1032@1|root,COG1032@2|Bacteria,3Y2NI@57723|Acidobacteria 57723|Acidobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM CMS2_k127_3356569_11 1337936.IJ00_08355 6.234e-13 72.0 2BK9M@1|root,32EPT@2|Bacteria,1G703@1117|Cyanobacteria,1HS5Z@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS2_k127_3356569_15 1499967.BAYZ01000036_gene2414 5.041e-11 63.0 2BK9M@1|root,32EPT@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_3356569_2 679197.HMPREF9336_01692 1.859e-170 557.0 2DUQG@1|root,33RR5@2|Bacteria 2|Bacteria S HCO3- transporter family - - - - - - - - - - - - HCO3_cotransp CMS2_k127_3356569_16 1121920.AUAU01000004_gene796 5.46e-08 55.0 COG0288@1|root,COG0288@2|Bacteria,3Y498@57723|Acidobacteria 57723|Acidobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA CMS2_k127_3356569_13 215803.DB30_5112 1.455e-11 72.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M2E@68525|delta/epsilon subdivisions,2WKAB@28221|Deltaproteobacteria,2YWDZ@29|Myxococcales 28221|Deltaproteobacteria K Transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat,V4R,XylR_N CMS2_k127_3356569_9 379066.GAU_1535 3.213e-33 132.0 COG0234@1|root,COG0234@2|Bacteria,1ZTZB@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 CMS2_k127_3356569_5 861299.J421_3164 1.072e-92 309.0 COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS2_k127_3356569_12 379066.GAU_1536 4.254e-12 67.0 COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS2_k127_3356569_17 1229512.BPAA_433 0.0005921 45.0 COG0459@1|root,COG0459@2|Bacteria,4NDZM@976|Bacteroidetes,1HX8K@117743|Flavobacteriia,3IVCI@39782|Blattabacteriaceae 976|Bacteroidetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS2_k127_3356569_3 290397.Adeh_2895 6.503e-164 539.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM CMS2_k127_3356569_8 344747.PM8797T_22458 3.975e-47 182.0 COG1741@1|root,COG1741@2|Bacteria,2IX1N@203682|Planctomycetes 203682|Planctomycetes S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin CMS2_k127_3357806_3 748247.AZKH_2145 4.908e-99 334.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1MU2H@1224|Proteobacteria,2VNEZ@28216|Betaproteobacteria,2KW92@206389|Rhodocyclales 206389|Rhodocyclales C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster bzdV - - - - - - - - - - - Fer2_4,Fer4_20,Fer4_7,Pyr_redox_2 CMS2_k127_3357806_5 1379698.RBG1_1C00001G0898 4.988e-38 144.0 COG1142@1|root,COG1142@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding - - - ko:K00205,ko:K02573 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002 - - - Fer2_4,Fer2_BFD,Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2 CMS2_k127_3357806_1 1379698.RBG1_1C00001G0897 1.252e-142 458.0 COG1924@1|root,COG1924@2|Bacteria,2NPG0@2323|unclassified Bacteria 2|Bacteria I BadF/BadG/BcrA/BcrD ATPase family hgdC - 1.3.7.8 ko:K04114 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - BcrAD_BadFG CMS2_k127_3357806_4 1379698.RBG1_1C00001G0896 9.675e-84 284.0 COG1924@1|root,COG1924@2|Bacteria,2NPG0@2323|unclassified Bacteria 2|Bacteria I BadF/BadG/BcrA/BcrD ATPase family - - 1.3.7.8 ko:K04115 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - BcrAD_BadFG CMS2_k127_3357806_0 1379698.RBG1_1C00001G0895 1.939e-237 739.0 COG1775@1|root,COG1775@2|Bacteria 2|Bacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D CMS2_k127_3357806_2 1379698.RBG1_1C00001G0894 3.128e-116 379.0 COG1775@1|root,COG1775@2|Bacteria,2NRF8@2323|unclassified Bacteria 2|Bacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D CMS2_k127_3358320_4 102125.Xen7305DRAFT_00026940 1.717e-11 67.0 COG0302@1|root,COG0302@2|Bacteria,1G1K8@1117|Cyanobacteria,3VIKW@52604|Pleurocapsales 1117|Cyanobacteria H TIGRFAM GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.folE,iJN678.folE GTP_cyclohydroI CMS2_k127_3358320_2 1304872.JAGC01000005_gene1959 7.339e-46 171.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MDPJ@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986,ko:K15342 - - - - ko00000,ko01000,ko02048,ko03400 - - - Cas_Cas1,GIIM,RVT_1 CMS2_k127_3358320_0 292459.STH1755 3.837e-112 372.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia 186801|Clostridia L Reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 CMS2_k127_3358320_5 1144312.PMI09_02611 6.964e-08 54.0 COG3344@1|root,COG3344@2|Bacteria 2|Bacteria L reverse transcriptase - - - - - - - - - - - - RVT_1 CMS2_k127_3358320_1 518766.Rmar_0916 9.521e-78 280.0 28P04@1|root,2ZBWU@2|Bacteria,4P2U7@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_3358320_3 861299.J421_3852 4.529e-27 115.0 COG1629@1|root,COG4771@2|Bacteria,1ZUGU@142182|Gemmatimonadetes 142182|Gemmatimonadetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_3359979_9 379066.GAU_3104 1.706e-96 337.0 COG1196@1|root,COG1196@2|Bacteria,1ZU8V@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - CMS2_k127_3359979_14 379066.GAU_3103 1.519e-81 297.0 COG1572@1|root,COG2304@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,1ZUB7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA,VWA_2 CMS2_k127_3359979_10 1379270.AUXF01000001_gene2298 1.72e-91 310.0 COG1721@1|root,COG1721@2|Bacteria,1ZUD5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 CMS2_k127_3359979_5 1379270.AUXF01000001_gene2299 3.948e-142 458.0 COG0714@1|root,COG0714@2|Bacteria,1ZUSV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS2_k127_3359979_15 1379270.AUXF01000001_gene2300 1.193e-79 273.0 29X7K@1|root,30IWU@2|Bacteria,1ZUTH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 CMS2_k127_3359979_4 1379270.AUXF01000001_gene2301 2.925e-155 522.0 COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,1ZUF5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - - CMS2_k127_3359979_20 1379270.AUXF01000001_gene2302 1.135e-62 228.0 COG4249@1|root,COG4249@2|Bacteria,1ZUQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase C14 caspase catalytic subunit p20 - - - - - - - - - - - - - CMS2_k127_3359979_2 1379270.AUXF01000001_gene2303 5.291e-178 583.0 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1ZUB1@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative glutamine amidotransferase - - - - - - - - - - - - GATase1_like CMS2_k127_3359979_22 1267535.KB906767_gene904 4.121e-57 209.0 2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria 57723|Acidobacteria S Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 CMS2_k127_3359979_23 745411.B3C1_02980 8.149e-44 168.0 COG0431@1|root,COG0431@2|Bacteria 745411.B3C1_02980|- S FMN reductase (NADPH) activity - - - - - - - - - - - - - CMS2_k127_3359979_21 1249627.D779_0406 5.756e-59 213.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1WW2T@135613|Chromatiales 135613|Chromatiales G TIGRFAM HAD-superfamily subfamily IIA hydrolase like protein - - - - - - - - - - - - Hydrolase_6,Hydrolase_like CMS2_k127_3359979_28 1229205.BUPH_01569 2.129e-09 68.0 COG0589@1|root,COG0589@2|Bacteria,1NZ7U@1224|Proteobacteria,2W3MC@28216|Betaproteobacteria,1K4K5@119060|Burkholderiaceae 28216|Betaproteobacteria T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp CMS2_k127_3359979_8 279714.FuraDRAFT_1793 4.185e-101 340.0 COG2040@1|root,COG2040@2|Bacteria,1QTE6@1224|Proteobacteria,2VNST@28216|Betaproteobacteria,2KTUC@206351|Neisseriales 206351|Neisseriales H Homocysteine S-methyltransferase - - 2.1.1.10 ko:K00547 ko00270,ko01100,ko01110,map00270,map01100,map01110 - R00650 RC00003,RC00035 ko00000,ko00001,ko01000 - - - S-methyl_trans CMS2_k127_3359979_0 234267.Acid_1951 8.199e-297 943.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Sortilin-Vps10 CMS2_k127_3359979_26 1227488.C477_20865 1.625e-17 96.0 COG0642@1|root,arCOG02330@1|root,arCOG02330@2157|Archaea,arCOG02358@2157|Archaea,2Y7KE@28890|Euryarchaeota 28890|Euryarchaeota T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4 CMS2_k127_3359979_19 880072.Desac_1827 4.531e-68 252.0 COG2202@1|root,COG2204@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria,2MSID@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1 CMS2_k127_3359979_3 266117.Rxyl_0070 1.068e-157 531.0 COG0383@1|root,COG0383@2|Bacteria,2GM02@201174|Actinobacteria 201174|Actinobacteria G PFAM Glycoside hydrolase, family 38 - - 3.2.1.170,3.2.1.24 ko:K01191,ko:K15524 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C CMS2_k127_3359979_13 1415778.JQMM01000001_gene761 1.371e-81 280.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1JC09@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0668 Small-conductance mechanosensitive channel mscS GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022607,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055082,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix CMS2_k127_3359979_27 1500259.JQLD01000002_gene2781 1.197e-16 87.0 COG2197@1|root,COG2197@2|Bacteria,1PHQY@1224|Proteobacteria,2V7U3@28211|Alphaproteobacteria,4BICX@82115|Rhizobiaceae 28211|Alphaproteobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg CMS2_k127_3359979_12 1137281.D778_00789 3.213e-83 283.0 COG3340@1|root,COG3340@2|Bacteria,4NEXW@976|Bacteroidetes,1HXTK@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the peptidase S51 family pepE - 3.4.13.21 ko:K05995 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S51 CMS2_k127_3359979_16 1307761.L21SP2_3221 8.02e-78 271.0 COG1208@1|root,COG1208@2|Bacteria,2J69H@203691|Spirochaetes 203691|Spirochaetes JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon - - - - - - - - - - - - NTP_transf_3,NTP_transferase CMS2_k127_3359979_24 1443665.JACA01000019_gene4814 6.005e-32 126.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1HWTC@117743|Flavobacteriia,2YGNN@290174|Aquimarina 976|Bacteroidetes E Sodium:solute symporter family - - - - - - - - - - - - SSF CMS2_k127_3359979_17 234267.Acid_6592 1.883e-73 262.0 COG0153@1|root,COG0153@2|Bacteria,3Y300@57723|Acidobacteria 2|Bacteria G Belongs to the GHMP kinase family. GalK subfamily - - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg CMS2_k127_3359979_18 1303692.SFUL_2436 2.08e-71 252.0 COG1524@1|root,COG1524@2|Bacteria,2HQI2@201174|Actinobacteria 201174|Actinobacteria I type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest CMS2_k127_3359979_11 1123508.JH636448_gene7625 3.284e-84 289.0 COG1402@1|root,COG1402@2|Bacteria 2|Bacteria I creatininase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS2_k127_3359979_6 551789.ATVJ01000001_gene1876 1.381e-138 469.0 COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,1RM62@1224|Proteobacteria,2UPDY@28211|Alphaproteobacteria,440IE@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - - - - - - - - - - PPC CMS2_k127_3359979_1 1121904.ARBP01000003_gene6372 1.547e-280 871.0 COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,47K7D@768503|Cytophagia 976|Bacteroidetes P esterase - - - - - - - - - - - - Esterase CMS2_k127_3359979_25 41431.PCC8801_0579 3.509e-29 123.0 COG1670@1|root,COG1670@2|Bacteria,1G7ZC@1117|Cyanobacteria 1117|Cyanobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_8 CMS2_k127_3359979_7 1196031.ALEG01000041_gene2496 1.581e-116 384.0 COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,4HCUU@91061|Bacilli,1ZR18@1386|Bacillus 91061|Bacilli E Ornithine cyclodeaminase/mu-crystallin family - - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall CMS2_k127_337604_5 1278073.MYSTI_01766 1.03e-187 623.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria 1224|Proteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_337604_22 234267.Acid_2305 8.817e-22 98.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZC@57723|Acidobacteria 57723|Acidobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR CMS2_k127_337604_9 926550.CLDAP_18370 8.841e-139 446.0 COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi 200795|Chloroflexi P PFAM Rhodanese domain protein - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese CMS2_k127_337604_18 880073.Calab_3409 6.92e-35 150.0 COG3330@1|root,COG3330@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4912) - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - DUF4912,PBP_like_2 CMS2_k127_337604_20 1437425.CSEC_2042 9.203e-26 115.0 COG4403@1|root,COG4403@2|Bacteria,2JHAZ@204428|Chlamydiae 204428|Chlamydiae V Lanthionine synthetase C family protein - - - - - - - - - - - - - CMS2_k127_337604_13 861299.J421_3108 2.859e-89 306.0 2F044@1|root,33T7T@2|Bacteria,1ZTDC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_337604_6 1210884.HG799464_gene10451 3.043e-182 580.0 COG0367@1|root,COG0367@2|Bacteria,2IYMU@203682|Planctomycetes 203682|Planctomycetes E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase CMS2_k127_337604_10 1210884.HG799464_gene10450 7.616e-98 331.0 COG1244@1|root,COG1244@2|Bacteria,2IX1W@203682|Planctomycetes 203682|Planctomycetes S Elongator protein 3, MiaB family, Radical SAM - - - ko:K06936 - - - - ko00000 - - - - CMS2_k127_337604_19 1382356.JQMP01000001_gene797 1.285e-29 122.0 COG1959@1|root,COG1959@2|Bacteria 2|Bacteria K 2 iron, 2 sulfur cluster binding - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 CMS2_k127_337604_8 195250.CM001776_gene3025 1.301e-152 512.0 COG0025@1|root,COG0664@1|root,COG0025@2|Bacteria,COG0664@2|Bacteria,1G1WP@1117|Cyanobacteria,1GZ0R@1129|Synechococcus 1117|Cyanobacteria P Sodium/hydrogen exchanger family - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger CMS2_k127_337604_17 469383.Cwoe_5609 1.37e-52 200.0 COG0558@1|root,COG0558@2|Bacteria,2H9R3@201174|Actinobacteria 201174|Actinobacteria I CDP-alcohol phosphatidyltransferase - - - - - - - - - - - - CDP-OH_P_transf CMS2_k127_337604_2 1123240.ATVO01000010_gene703 4.617e-215 683.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,2K9UC@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 CMS2_k127_337604_16 383372.Rcas_0286 6.015e-68 239.0 COG1011@1|root,COG1011@2|Bacteria,2G916@200795|Chloroflexi,377HS@32061|Chloroflexia 32061|Chloroflexia S PFAM Haloacid dehalogenase domain protein hydrolase - - 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 CMS2_k127_337604_14 97096.XP_007791457.1 8.14e-86 293.0 COG4242@1|root,2SDNU@2759|Eukaryota,39XTH@33154|Opisthokonta,3P089@4751|Fungi,3QN1Z@4890|Ascomycota,21E90@147550|Sordariomycetes 4751|Fungi PQ Peptidase family S51 - - - - - - - - - - - - Peptidase_S51 CMS2_k127_337604_24 860228.Ccan_20840 3.238e-09 67.0 COG0671@1|root,COG0671@2|Bacteria,4NMKG@976|Bacteroidetes,1I896@117743|Flavobacteriia 976|Bacteroidetes I PAP2 superfamily - - - - - - - - - - - - PAP2_3 CMS2_k127_337604_15 1173264.KI913949_gene1162 1.766e-76 262.0 COG2818@1|root,COG2818@2|Bacteria,1G5Y1@1117|Cyanobacteria 1117|Cyanobacteria L Methyladenine glycosylase - - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco CMS2_k127_337604_12 34506.g5530 3.758e-93 323.0 COG0079@1|root,KOG0633@2759|Eukaryota,38DTP@33154|Opisthokonta,3CKZX@33208|Metazoa,3E2KH@33213|Bilateria,40Q9R@6231|Nematoda,1M7TB@119089|Chromadorea,416F3@6236|Rhabditida 33208|Metazoa E Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 CMS2_k127_337604_7 1210884.HG799464_gene10982 7.671e-171 548.0 COG1236@1|root,COG1236@2|Bacteria,2IXNS@203682|Planctomycetes 203682|Planctomycetes J Exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL CMS2_k127_337604_0 1047013.AQSP01000130_gene1854 5.221e-290 904.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NNS9@2323|unclassified Bacteria 2|Bacteria EU peptidase S9 prolyl oligopeptidase active site - - - - - - - - - - - - DPPIV_N,FGE-sulfatase,PD40,Peptidase_S9 CMS2_k127_337604_3 309807.SRU_2275 1.056e-202 652.0 COG0531@1|root,COG0569@1|root,COG1762@1|root,COG0531@2|Bacteria,COG0569@2|Bacteria,COG1762@2|Bacteria,4NDU2@976|Bacteroidetes,1FJTH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EGPT Amino acid permease - - - - - - - - - - - - AA_permease,AA_permease_2,PTS_EIIA_2,TrkA_C,Usp CMS2_k127_337604_1 1120966.AUBU01000005_gene3785 2.715e-256 800.0 COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,47K06@768503|Cytophagia 976|Bacteroidetes E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS2_k127_337604_4 518766.Rmar_0345 1.901e-190 608.0 COG1473@1|root,COG1473@2|Bacteria,4NEKH@976|Bacteroidetes 976|Bacteroidetes S TIGRFAM amidohydrolase - - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 CMS2_k127_337604_11 861299.J421_6371 5.777e-96 333.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6371|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_3429624_6 419947.MRA_1850 1.26e-16 82.0 2BE1Z@1|root,327SM@2|Bacteria,2HDGJ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS2_k127_3429624_4 419947.MRA_1849 1.138e-39 153.0 COG1848@1|root,COG1848@2|Bacteria 2|Bacteria G Toxic component of a toxin-antitoxin (TA) module. An RNase - GO:0005575,GO:0005576 - ko:K07064 - - - - ko00000 - - - PIN CMS2_k127_3429624_5 351607.Acel_1033 3.572e-31 130.0 COG4747@1|root,COG4747@2|Bacteria 2|Bacteria - - hom - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00570 R00220,R00996,R01513,R01773,R01775 RC00031,RC00087,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3 CMS2_k127_3429624_3 1173024.KI912149_gene6516 5.322e-75 266.0 28JGA@1|root,2Z9A3@2|Bacteria,1G1Q6@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS2_k127_3429624_2 861299.J421_0460 2.239e-131 436.0 COG1807@1|root,COG1807@2|Bacteria,1ZUFB@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 CMS2_k127_3429624_0 234267.Acid_0260 1.173e-202 646.0 COG0627@1|root,COG0627@2|Bacteria 2|Bacteria J Serine hydrolase involved in the detoxification of formaldehyde - - - - - - - - - - - - Esterase,Tannase CMS2_k127_3429624_1 1206729.BAFZ01000165_gene5751 1.3e-146 485.0 COG0657@1|root,COG0657@2|Bacteria,2GNIV@201174|Actinobacteria,4G6KX@85025|Nocardiaceae 201174|Actinobacteria I acetylesterase activity - - - - - - - - - - - - - CMS2_k127_3429624_7 1121904.ARBP01000017_gene5075 2.605e-09 69.0 COG2730@1|root,COG3291@1|root,COG4625@1|root,COG5492@1|root,COG2730@2|Bacteria,COG3291@2|Bacteria,COG4625@2|Bacteria,COG5492@2|Bacteria,4NJ9A@976|Bacteroidetes,47M79@768503|Cytophagia 976|Bacteroidetes N Bacterial Ig-like domain (group 2) - - - - - - - - - - - - BACON,Big_2,F5_F8_type_C,LRR_5,Polysacc_deac_3 CMS2_k127_3429624_8 9305.ENSSHAP00000015466 3.858e-06 59.0 COG4886@1|root,KOG4641@2759|Eukaryota,38EYJ@33154|Opisthokonta,3BIA8@33208|Metazoa,3CVNH@33213|Bilateria,47ZUZ@7711|Chordata,498G9@7742|Vertebrata,3JD5E@40674|Mammalia,4K8DT@9263|Metatheria 33208|Metazoa T Toll - interleukin 1 - resistance - GO:0001932,GO:0002218,GO:0002221,GO:0002224,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0002755,GO:0002757,GO:0002758,GO:0002764,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005886,GO:0005887,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007154,GO:0007165,GO:0008150,GO:0009605,GO:0009607,GO:0009615,GO:0009966,GO:0009987,GO:0010646,GO:0012505,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0019843,GO:0023051,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031347,GO:0031349,GO:0031399,GO:0031410,GO:0031982,GO:0032268,GO:0034178,GO:0042325,GO:0042802,GO:0042803,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043408,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045087,GO:0045088,GO:0045089,GO:0046983,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051174,GO:0051246,GO:0051704,GO:0051707,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0080134,GO:0097159,GO:0097708,GO:1901363,GO:1902531 - ko:K18808 - - - - ko00000 - - - LRR_8,TIR CMS2_k127_3575528_5 478801.Ksed_06880 1.676e-42 162.0 COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,1ZWE4@145357|Dermacoccaceae 201174|Actinobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_3575528_6 479434.Sthe_1082 8.179e-36 150.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 CMS2_k127_3575528_2 66373.JOFQ01000008_gene323 6.659e-96 326.0 COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria 201174|Actinobacteria V abc transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_3575528_4 411684.HPDFL43_14972 5.205e-55 206.0 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,43KPD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 CMS2_k127_3575528_1 861299.J421_1342 1.078e-109 368.0 COG2207@1|root,COG2207@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - HTH_18 CMS2_k127_3575528_3 391625.PPSIR1_01062 1.137e-82 286.0 COG2267@1|root,COG2267@2|Bacteria,1RBQF@1224|Proteobacteria 1224|Proteobacteria I alpha/beta hydrolase fold - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 CMS2_k127_3575528_7 1229487.AMYW01000021_gene1729 2.923e-15 89.0 COG4775@1|root,COG4775@2|Bacteria,4NRT9@976|Bacteroidetes,1I4PV@117743|Flavobacteriia,2NYF2@237|Flavobacterium 976|Bacteroidetes M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - CMS2_k127_3575528_0 1254432.SCE1572_02795 1.126e-119 405.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS2_k127_3575528_9 616991.JPOO01000001_gene3323 0.0002654 51.0 2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1HZN8@117743|Flavobacteriia,23HX8@178469|Arenibacter 976|Bacteroidetes S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 CMS2_k127_3575528_8 1047013.AQSP01000097_gene1952 4.712e-12 78.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,TolB_like CMS2_k127_3589826_11 861299.J421_3135 7.901e-05 46.0 COG1381@1|root,COG1381@2|Bacteria,1ZTHP@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N CMS2_k127_3589826_2 861299.J421_3134 1.943e-143 479.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity btuB - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec CMS2_k127_3589826_5 1254432.SCE1572_43760 2.919e-53 201.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2X84B@28221|Deltaproteobacteria,2Z3KP@29|Myxococcales 28221|Deltaproteobacteria P ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran CMS2_k127_3589826_4 861299.J421_3132 1.586e-75 264.0 COG0609@1|root,COG0609@2|Bacteria,1ZTAA@142182|Gemmatimonadetes 142182|Gemmatimonadetes P FecCD transport family - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD CMS2_k127_3589826_7 861299.J421_3131 5.261e-47 180.0 COG0614@1|root,COG0614@2|Bacteria,1ZTIM@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 CMS2_k127_3589826_9 861299.J421_3130 1.084e-28 130.0 COG2010@1|root,COG2010@2|Bacteria,1ZT9T@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c - - - - - - - - - - - - - CMS2_k127_3589826_6 861299.J421_3129 1.462e-51 192.0 COG1259@1|root,COG1259@2|Bacteria,1ZTKW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase CMS2_k127_3589826_0 861299.J421_2862 1.525e-245 766.0 COG0499@1|root,COG0499@2|Bacteria,1ZTEF@142182|Gemmatimonadetes 142182|Gemmatimonadetes H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD CMS2_k127_3589826_1 861299.J421_3128 7.015e-165 527.0 COG0192@1|root,COG0192@2|Bacteria,1ZSZ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N CMS2_k127_3589826_3 697303.Thewi_2296 1.697e-117 400.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales 186801|Clostridia G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsP - 2.7.3.9,2.7.9.2 ko:K01007,ko:K08483 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C CMS2_k127_3589826_10 1379270.AUXF01000005_gene735 6.292e-23 107.0 COG1925@1|root,COG1925@2|Bacteria,1ZTYE@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS HPr component phosphorylation site - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr CMS2_k127_3589826_8 861299.J421_3125 3.634e-29 124.0 COG3716@1|root,COG3716@2|Bacteria,1ZTJH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system mannose/fructose/sorbose family IID component - - - ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EIID-AGA CMS2_k127_3621870_0 1384054.N790_12220 2.924e-115 392.0 COG0471@1|root,COG3273@1|root,COG0471@2|Bacteria,COG3273@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1X4VE@135614|Xanthomonadales 135614|Xanthomonadales P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C CMS2_k127_3621870_1 880073.Calab_0673 1.122e-57 210.0 COG1262@1|root,COG1262@2|Bacteria,2NR84@2323|unclassified Bacteria 2|Bacteria S Sulfatase-modifying factor enzyme 1 gldK - - - - - - - - - - - FGE-sulfatase CMS2_k127_3621870_2 1407650.BAUB01000002_gene499 2.953e-09 64.0 2E81V@1|root,332FX@2|Bacteria,1G996@1117|Cyanobacteria,1H1BQ@1129|Synechococcus 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS2_k127_3621870_3 251221.35211983 1.488e-08 56.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_362375_0 1124780.ANNU01000002_gene1595 1.516e-207 671.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NF70@976|Bacteroidetes,47JEZ@768503|Cytophagia 976|Bacteroidetes EU Peptidase S9, prolyl oligopeptidase active site domain protein - - - - - - - - - - - - DPPIV_N,PD40,Peptidase_S9 CMS2_k127_362375_1 379066.GAU_3920 1.911e-73 269.0 COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,1ZTYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Leishmanolysin - - - - - - - - - - - - Peptidase_M8 CMS2_k127_362375_2 861299.J421_3690 3.716e-35 156.0 COG5492@1|root,COG5492@2|Bacteria,1ZT2D@142182|Gemmatimonadetes 142182|Gemmatimonadetes N domain, Protein - - - - - - - - - - - - - CMS2_k127_3675056_9 861299.J421_2359 2.305e-148 499.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_2359|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_3675056_23 861299.J421_6344 1.801e-30 123.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_3675056_29 945713.IALB_3132 1.348e-10 73.0 2C2F5@1|root,32WND@2|Bacteria 2|Bacteria - - VPA0561 - - - - - - - - - - - - CMS2_k127_3675056_19 1499967.BAYZ01000167_gene6761 7.832e-52 194.0 COG2834@1|root,COG2834@2|Bacteria,2NQGF@2323|unclassified Bacteria 2|Bacteria M MucB/RseB N-terminal domain - - - - - - - - - - - - LolA_like CMS2_k127_3675056_18 373903.Hore_23230 2.074e-54 207.0 COG4591@1|root,COG4591@2|Bacteria,1UJT2@1239|Firmicutes,24E7N@186801|Clostridia,3WABX@53433|Halanaerobiales 186801|Clostridia M ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_3675056_17 158190.SpiGrapes_2216 8.554e-60 224.0 COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes 203691|Spirochaetes M ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_3675056_15 748449.Halha_0932 2.053e-73 254.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3WB27@53433|Halanaerobiales 186801|Clostridia V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_3675056_22 357808.RoseRS_0464 1.402e-37 151.0 COG1378@1|root,COG1378@2|Bacteria,2GANE@200795|Chloroflexi,376UQ@32061|Chloroflexia 32061|Chloroflexia K PFAM transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB CMS2_k127_3675056_2 379066.GAU_3235 5.62e-209 677.0 COG2091@1|root,COG2091@2|Bacteria,1ZUGF@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - CMS2_k127_3675056_1 880073.Calab_0341 6.525e-223 701.0 COG2986@1|root,COG2986@2|Bacteria,2NQHF@2323|unclassified Bacteria 2|Bacteria E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic CMS2_k127_3675056_30 66897.DJ64_31970 6.251e-06 51.0 COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria 201174|Actinobacteria O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ahpE - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - AhpC-TSA CMS2_k127_3675056_21 293826.Amet_3778 3.699e-39 148.0 COG1225@1|root,COG1225@2|Bacteria,1VBNH@1239|Firmicutes,24QGI@186801|Clostridia 186801|Clostridia O Redoxin - - - - - - - - - - - - AhpC-TSA CMS2_k127_3675056_28 234267.Acid_1967 1.59e-13 74.0 COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Sortilin-Vps10 CMS2_k127_3675056_6 861299.J421_3786 4.708e-157 504.0 COG0282@1|root,COG0282@2|Bacteria,1ZT9P@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase CMS2_k127_3675056_4 861299.J421_4263 8.892e-178 571.0 COG2234@1|root,COG2234@2|Bacteria,1ZT06@142182|Gemmatimonadetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS2_k127_3675056_3 404589.Anae109_3731 2.124e-179 593.0 COG4775@1|root,COG4775@2|Bacteria 2|Bacteria M membrane organization - - - - - - - - - - - - Bac_surface_Ag,CarboxypepD_reg,Laminin_G_3,POTRA CMS2_k127_3675056_5 1183438.GKIL_4354 1.69e-162 547.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_3675056_25 1267533.KB906734_gene4016 7.909e-26 110.0 COG1695@1|root,COG1695@2|Bacteria,3Y8CC@57723|Acidobacteria,2JP3G@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_3675056_16 1379270.AUXF01000002_gene1577 1.445e-72 267.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_3675056_14 1379270.AUXF01000002_gene1577 2.562e-74 269.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_3675056_8 204669.Acid345_4142 4.707e-150 500.0 COG1505@1|root,COG1505@2|Bacteria,3Y2UH@57723|Acidobacteria,2JI70@204432|Acidobacteriia 204432|Acidobacteriia E Prolyl oligopeptidase - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N CMS2_k127_3675056_12 382464.ABSI01000006_gene803 1.923e-91 310.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase - - - - - - - - - - - - Aldo_ket_red,HEAT_2,TetR_C_7,TetR_N CMS2_k127_3675056_13 909613.UO65_2245 8.779e-85 291.0 COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4DYPU@85010|Pseudonocardiales 201174|Actinobacteria S Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine egtD - 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 CMS2_k127_3675056_27 435590.BVU_2507 3.129e-14 87.0 2CF1V@1|root,2Z9BC@2|Bacteria,4NHGM@976|Bacteroidetes,2FNUI@200643|Bacteroidia,4AN3Z@815|Bacteroidaceae 976|Bacteroidetes S Protein of unknown function (DUF4876) - - - - - - - - - - - - DUF4876 CMS2_k127_3675056_11 1048983.EL17_01215 2.242e-92 337.0 COG1629@1|root,COG4771@2|Bacteria,4PKF9@976|Bacteroidetes,47THC@768503|Cytophagia 976|Bacteroidetes P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_3675056_24 357808.RoseRS_3392 2.158e-26 125.0 COG1413@1|root,COG1413@2|Bacteria,2G6UU@200795|Chloroflexi 200795|Chloroflexi C PBS lyase HEAT domain protein repeat-containing protein - - - - - - - - - - - - HEAT_2,HEAT_PBS CMS2_k127_3675056_20 861299.J421_4375 5.748e-43 166.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_3675056_7 861299.J421_6141 7.793e-156 525.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6141|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_3675056_26 1348114.OM33_20420 4.493e-23 102.0 COG1695@1|root,COG1695@2|Bacteria,1N4DF@1224|Proteobacteria,1SBH1@1236|Gammaproteobacteria,2Q31Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K transcriptional regulators - - - - - - - - - - - - PadR CMS2_k127_3675056_10 479434.Sthe_2780 7.202e-125 423.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G7MH@200795|Chloroflexi,27XJR@189775|Thermomicrobia 189775|Thermomicrobia EU Peptidase S9, prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 CMS2_k127_3675056_0 1379270.AUXF01000002_gene1345 7.937e-230 745.0 COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_3693090_2 448385.sce3387 1.835e-53 203.0 COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales 28221|Deltaproteobacteria S cellulose binding - - - - - - - - - - - - - CMS2_k127_3693090_5 1250006.JHZZ01000001_gene1907 3.823e-22 100.0 COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1IKMP@117743|Flavobacteriia 976|Bacteroidetes M 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP CMS2_k127_3693090_3 1173029.JH980292_gene43 1.625e-37 142.0 COG0211@1|root,COG0211@2|Bacteria,1G7RW@1117|Cyanobacteria,1HCCX@1150|Oscillatoriales 1117|Cyanobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 CMS2_k127_3693090_4 861299.J421_3337 6.084e-31 124.0 COG0261@1|root,COG0261@2|Bacteria,1ZTS8@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p CMS2_k127_3693090_1 880073.Calab_2283 2.549e-119 400.0 COG1530@1|root,COG1530@2|Bacteria,2NNQR@2323|unclassified Bacteria 2|Bacteria J Ribonuclease E/G family rng - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 CMS2_k127_3693090_0 1121918.ARWE01000001_gene2669 2.634e-137 465.0 COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,43RXX@69541|Desulfuromonadales 28221|Deltaproteobacteria C Uncharacterized protein conserved in bacteria (DUF2344) - - - - - - - - - - - - DUF2344,Radical_SAM CMS2_k127_3845627_6 1121875.KB907549_gene1882 2.305e-60 217.0 COG0823@1|root,COG0823@2|Bacteria,4NIV7@976|Bacteroidetes,1IJ1H@117743|Flavobacteriia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_3845627_0 1121957.ATVL01000008_gene4409 2.406e-310 972.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,47UBJ@768503|Cytophagia 976|Bacteroidetes G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C CMS2_k127_3845627_2 761193.Runsl_4865 2.431e-250 782.0 COG2272@1|root,COG2272@2|Bacteria,4NG5B@976|Bacteroidetes,47JGD@768503|Cytophagia 976|Bacteroidetes I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase CMS2_k127_3845627_1 861299.J421_6339 6.573e-275 858.0 COG3507@1|root,COG3507@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_43 CMS2_k127_3845627_8 195250.CM001776_gene3333 1.794e-47 182.0 COG0637@1|root,COG0637@2|Bacteria,1G2T2@1117|Cyanobacteria,1GZ2D@1129|Synechococcus 1117|Cyanobacteria S HAD-superfamily hydrolase subfamily IA, variant 3 - - - - - - - - - - - - HAD_2 CMS2_k127_3845627_7 1163409.UUA_03143 1.083e-57 209.0 COG0637@1|root,COG0637@2|Bacteria,1QXCM@1224|Proteobacteria,1T47N@1236|Gammaproteobacteria,1X62V@135614|Xanthomonadales 135614|Xanthomonadales S Haloacid dehalogenase-like hydrolase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 CMS2_k127_3845627_5 1408473.JHXO01000009_gene3462 4.893e-94 319.0 COG3394@1|root,COG3394@2|Bacteria,4PNAT@976|Bacteroidetes,2G14M@200643|Bacteroidia 976|Bacteroidetes G YdjC-like protein - - 3.5.1.105 ko:K03478 - - - - ko00000,ko01000 - - - YdjC CMS2_k127_3845627_3 1123278.KB893422_gene1620 1.045e-223 705.0 COG1231@1|root,COG1231@2|Bacteria,4PMAQ@976|Bacteroidetes,47N7X@768503|Cytophagia 976|Bacteroidetes E Protein of unknown function (DUF1593) - - - - - - - - - - - - DUF1593 CMS2_k127_3845627_9 388413.ALPR1_07745 8.507e-30 124.0 2EBYS@1|root,335Y2@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 CMS2_k127_3845627_4 518766.Rmar_0694 5.534e-169 537.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,4NEM0@976|Bacteroidetes 976|Bacteroidetes IQ Rhamnulose-1-phosphate aldolase alcohol dehydrogenase - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 CMS2_k127_3925226_2 1254432.SCE1572_34585 3.664e-22 100.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) tnp3510a - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 CMS2_k127_3925226_4 1379270.AUXF01000002_gene1589 0.0001643 45.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_3925226_1 768710.DesyoDRAFT_1775 2.124e-127 430.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - ko:K22318 - - - - ko00000 - - - B12-binding,Radical_SAM CMS2_k127_3925226_0 246197.MXAN_0537 2.787e-150 490.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2YWP2@29|Myxococcales 28221|Deltaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsA - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N CMS2_k127_3925226_3 596154.Alide2_1830 1.624e-17 87.0 COG2963@1|root,COG2963@2|Bacteria,1N2T5@1224|Proteobacteria,2WENN@28216|Betaproteobacteria,4AFZ1@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Transposase IS3 - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 CMS2_k127_3935666_11 1267535.KB906767_gene2485 5.641e-68 242.0 COG0506@1|root,COG0506@2|Bacteria,3Y2G8@57723|Acidobacteria,2JHRI@204432|Acidobacteriia 204432|Acidobacteriia E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh CMS2_k127_3935666_19 215803.DB30_7152 1.045e-53 192.0 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2WRHK@28221|Deltaproteobacteria,2Z03M@29|Myxococcales 28221|Deltaproteobacteria S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 CMS2_k127_3935666_24 1219065.VPR01S_05_00420 8.618e-35 142.0 COG0824@1|root,COG0824@2|Bacteria,1RHCN@1224|Proteobacteria,1S4PS@1236|Gammaproteobacteria,1XXBU@135623|Vibrionales 135623|Vibrionales S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 CMS2_k127_3935666_12 379066.GAU_1514 8.674e-68 238.0 COG2065@1|root,COG2065@2|Bacteria,1ZTHG@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran CMS2_k127_3935666_4 861299.J421_3142 4.396e-163 518.0 COG0540@1|root,COG0540@2|Bacteria,1ZSN7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS2_k127_3935666_2 861299.J421_3143 2.816e-178 576.0 COG0044@1|root,COG0044@2|Bacteria,1ZT4U@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 CMS2_k127_3935666_25 649747.HMPREF0083_01731 4.251e-32 131.0 COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,4HG91@91061|Bacilli,26TR3@186822|Paenibacillaceae 91061|Bacilli G Aldolase - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II CMS2_k127_3935666_26 861299.J421_3144 1.558e-17 93.0 COG1196@1|root,COG1196@2|Bacteria,1ZU4J@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Zinc finger domain - - - - - - - - - - - - - CMS2_k127_3935666_28 323261.Noc_3037 4.384e-06 54.0 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1WYU8@135613|Chromatiales 135613|Chromatiales J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p CMS2_k127_3935666_13 861299.J421_3146 1.748e-65 230.0 COG1994@1|root,COG1994@2|Bacteria,1ZTIB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 CMS2_k127_3935666_14 861299.J421_3147 2.644e-62 223.0 COG1354@1|root,COG1354@2|Bacteria,1ZT1G@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA CMS2_k127_3935666_16 379066.GAU_1522 1.578e-58 208.0 COG1386@1|root,COG1386@2|Bacteria,1ZTIA@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB CMS2_k127_3935666_18 861299.J421_3149 5.222e-57 207.0 COG1187@1|root,COG1187@2|Bacteria,1ZT5B@142182|Gemmatimonadetes 142182|Gemmatimonadetes J S4 RNA-binding domain - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 CMS2_k127_3935666_5 869210.Marky_1233 2.274e-154 507.0 COG1086@1|root,COG1086@2|Bacteria 2|Bacteria GM Polysaccharide biosynthesis protein - - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3,Glycos_transf_4,HTH_45,LicD CMS2_k127_3935666_6 861299.J421_3150 1.061e-139 450.0 COG0714@1|root,COG0714@2|Bacteria,1ZT94@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS2_k127_3935666_9 1379270.AUXF01000005_gene779 3.203e-80 278.0 COG1721@1|root,COG1721@2|Bacteria,1ZSKR@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 CMS2_k127_3935666_8 379066.GAU_1527 9.056e-91 311.0 COG2304@1|root,COG2304@2|Bacteria,1ZSVY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF1194) - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA CMS2_k127_3935666_21 1265505.ATUG01000002_gene2733 1.536e-40 169.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2WM19@28221|Deltaproteobacteria,2MHT6@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM von Willebrand factor type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,TPR_1,TPR_16,TPR_2,VWA,VWA_2 CMS2_k127_3935666_23 861299.J421_3154 6.021e-37 161.0 COG4783@1|root,COG4783@2|Bacteria,1ZT36@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Oxygen tolerance - - - - - - - - - - - - BatD,SH3_4 CMS2_k127_3935666_3 861299.J421_3155 1.477e-170 554.0 COG0323@1|root,COG0323@2|Bacteria,1ZT6V@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C CMS2_k127_3935666_17 861299.J421_3156 3.398e-58 216.0 COG0324@1|root,COG0324@2|Bacteria,1ZTBB@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT CMS2_k127_3935666_7 379066.GAU_1532 1.6e-125 413.0 COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,1ZT2W@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase 4-like - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 CMS2_k127_3935666_20 867903.ThesuDRAFT_00213 6.812e-45 177.0 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,3WCHZ@538999|Clostridiales incertae sedis 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA CMS2_k127_3935666_22 379066.GAU_1534 8.124e-40 158.0 COG0340@1|root,COG0340@2|Bacteria,1ZTQ7@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Biotin/lipoate A/B protein ligase family - - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_LplA_LipB CMS2_k127_3935666_15 1122223.KB890700_gene1978 3.033e-60 218.0 COG1521@1|root,COG1521@2|Bacteria,1WI0G@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase CMS2_k127_3935666_1 671143.DAMO_2917 3.404e-259 816.0 COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria 2|Bacteria O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - Aldo_ket_red,GlcNAc_2-epim,Thioredox_DsbH CMS2_k127_3935666_31 1122176.KB903532_gene2669 4.781e-05 50.0 COG3291@1|root,COG3291@2|Bacteria,4PKTY@976|Bacteroidetes 976|Bacteroidetes O ASPIC and UnbV - - - - - - - - - - - - PKD,UnbV_ASPIC,VCBS CMS2_k127_3935666_0 861299.J421_4032 4.43e-321 1021.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_4032|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_3935666_10 316067.Geob_1840 5.778e-77 263.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,43BI9@68525|delta/epsilon subdivisions,2X6WN@28221|Deltaproteobacteria,43U6T@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 CMS2_k127_3935666_30 1089551.KE386572_gene514 2.944e-05 56.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,4BQ1V@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L Phage integrase, N-terminal SAM-like domain xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase CMS2_k127_396756_2 1254432.SCE1572_08615 2.39e-44 166.0 COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,4319X@68525|delta/epsilon subdivisions,2WWBK@28221|Deltaproteobacteria,2Z397@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome c mono- and diheme variants - - - - - - - - - - - - - CMS2_k127_396756_4 234267.Acid_3395 3.531e-34 138.0 2FGUY@1|root,348Q9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_396756_3 383372.Rcas_2310 1.496e-36 142.0 COG0640@1|root,COG0640@2|Bacteria,2G7FZ@200795|Chloroflexi,375Z9@32061|Chloroflexia 32061|Chloroflexia K PFAM regulatory protein, ArsR - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 CMS2_k127_396756_6 404380.Gbem_1190 6.867e-24 106.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 CMS2_k127_396756_1 1499967.BAYZ01000181_gene4512 2.819e-74 258.0 COG0500@1|root,COG2226@2|Bacteria,2NRU6@2323|unclassified Bacteria 2|Bacteria Q Nodulation protein S (NodS) - - - - - - - - - - - - HTH_17,Methyltransf_11,Methyltransf_31,Sigma70_r2,Sigma70_r4_2 CMS2_k127_396756_0 593750.Metfor_0951 2.151e-108 360.0 COG1456@1|root,arCOG06909@2157|Archaea,2Y2FW@28890|Euryarchaeota,2NAAQ@224756|Methanomicrobia 224756|Methanomicrobia C CO dehydrogenase/acetyl-CoA synthase delta subunit - - - - - - - - - - - - CdhD CMS2_k127_396756_5 304371.MCP_0717 2.072e-26 111.0 arCOG06908@1|root,arCOG06908@2157|Archaea,2Y41J@28890|Euryarchaeota,2NB0E@224756|Methanomicrobia 224756|Methanomicrobia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 CMS2_k127_396756_8 765912.Thimo_0400 2.536e-17 90.0 COG1670@1|root,COG1670@2|Bacteria,1NEA7@1224|Proteobacteria,1SEG2@1236|Gammaproteobacteria 1236|Gammaproteobacteria J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - - - - - - - - - - - CMS2_k127_396756_13 635013.TherJR_1023 0.0004789 52.0 COG3391@1|root,COG3391@2|Bacteria,1VCN6@1239|Firmicutes 1239|Firmicutes S PFAM NHL repeat containing protein - - - - - - - - - - - - NHL CMS2_k127_396756_7 1300345.LF41_2902 3.855e-23 104.0 arCOG10603@1|root,32SV6@2|Bacteria,1MYDK@1224|Proteobacteria,1SG7U@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_398217_12 1051646.VITU9109_14061 1.188e-44 174.0 COG0265@1|root,COG3291@1|root,COG0265@2|Bacteria,COG3291@2|Bacteria,1R6VW@1224|Proteobacteria,1SNEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Pkd domain containing protein - - - - - - - - - - - - - CMS2_k127_398217_8 670487.Ocepr_1417 2.542e-61 219.0 COG1647@1|root,COG1647@2|Bacteria 2|Bacteria M Serine aminopeptidase, S33 - - 3.1.1.1,3.1.1.85 ko:K02170,ko:K03928 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 CMS2_k127_398217_3 1463857.JOFZ01000004_gene3030 1.407e-112 373.0 COG0726@1|root,COG0726@2|Bacteria,2GM0X@201174|Actinobacteria 201174|Actinobacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 CMS2_k127_398217_7 1122919.KB905570_gene3016 1.538e-61 225.0 COG1708@1|root,COG1708@2|Bacteria,1VA5E@1239|Firmicutes,4HKEA@91061|Bacilli,26U9Q@186822|Paenibacillaceae 91061|Bacilli S KNTase C-terminal domain - - - ko:K17882 - - - - ko00000,ko01000,ko01504 - - - KNTase_C CMS2_k127_398217_11 452637.Oter_0019 3.667e-45 168.0 COG3449@1|root,COG3449@2|Bacteria 2|Bacteria K DNA topoisomerase (ATP-hydrolyzing) inhibitor activity - - - ko:K13652,ko:K13653 - - - - ko00000,ko03000 - - - Cass2,GyrI-like,HTH_18 CMS2_k127_398217_10 1205680.CAKO01000040_gene560 3.379e-50 186.0 COG4032@1|root,COG4032@2|Bacteria,1P0HU@1224|Proteobacteria,2TRJ2@28211|Alphaproteobacteria,2JS9A@204441|Rhodospirillales 204441|Rhodospirillales S Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_N CMS2_k127_398217_6 1038859.AXAU01000006_gene5612 4.495e-64 227.0 COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TXAJ@28211|Alphaproteobacteria,3JUDG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain MA20_16820 - - - - - - - - - - - TPP_enzyme_C CMS2_k127_398217_16 648996.Theam_1102 4.607e-19 91.0 COG2204@1|root,COG2204@2|Bacteria,2G3T9@200783|Aquificae 200783|Aquificae T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_398217_20 118161.KB235922_gene3936 3.149e-14 82.0 2C4HM@1|root,2ZFRV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_398217_1 1379270.AUXF01000004_gene3069 6.891e-161 525.0 28M0D@1|root,2ZAFE@2|Bacteria,1ZUP5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative ATP-binding cassette - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran_2 CMS2_k127_398217_4 1379270.AUXF01000004_gene3068 4.254e-104 344.0 COG1131@1|root,COG1131@2|Bacteria,1ZUPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_398217_9 177437.HRM2_33700 2.576e-59 228.0 COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,42R14@68525|delta/epsilon subdivisions,2WN3R@28221|Deltaproteobacteria,2MJNR@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM transglutaminase domain protein - - - - - - - - - - - - Transglut_core CMS2_k127_398217_21 891968.Anamo_1817 1.013e-10 69.0 COG2110@1|root,COG2110@2|Bacteria,3TB5Z@508458|Synergistetes 508458|Synergistetes S C-terminal domain of histone - - - - - - - - - - - - Macro CMS2_k127_398217_18 247490.KSU1_D1057 4.394e-17 92.0 COG0457@1|root,COG0457@2|Bacteria,2IYMF@203682|Planctomycetes 203682|Planctomycetes M Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 CMS2_k127_398217_14 861299.J421_2745 1.956e-26 113.0 COG1324@1|root,COG1324@2|Bacteria,1ZV6V@142182|Gemmatimonadetes 142182|Gemmatimonadetes P CutA1 divalent ion tolerance protein - - - ko:K03926 - - - - ko00000 - - - CutA1 CMS2_k127_398217_0 861299.J421_2748 0.0 1364.0 COG0178@1|root,COG0178@2|Bacteria,1ZTDJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran CMS2_k127_398217_5 1379270.AUXF01000004_gene3061 3.789e-75 261.0 COG1842@1|root,COG1842@2|Bacteria,1ZT82@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT PspA/IM30 family - - - ko:K03969 - - - - ko00000 - - - PspA_IM30 CMS2_k127_398217_13 398580.Dshi_3196 3.48e-28 127.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TSI2@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC transporter nosF - - ko:K01990,ko:K19340 ko02010,map02010 M00254,M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 - - ABC_tran CMS2_k127_398217_17 177437.HRM2_46800 1.077e-18 95.0 COG0509@1|root,COG0509@2|Bacteria,1RC80@1224|Proteobacteria,42R79@68525|delta/epsilon subdivisions,2WN04@28221|Deltaproteobacteria,2MJJZ@213118|Desulfobacterales 28221|Deltaproteobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H CMS2_k127_398217_15 404589.Anae109_1802 1.389e-21 103.0 COG0509@1|root,COG0509@2|Bacteria,1RC80@1224|Proteobacteria,42R79@68525|delta/epsilon subdivisions,2WN04@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Glycine cleavage H-protein - - - - - - - - - - - - GCV_H CMS2_k127_398217_2 861299.J421_2757 5.05e-159 516.0 COG0215@1|root,COG0215@2|Bacteria,1ZT77@142182|Gemmatimonadetes 142182|Gemmatimonadetes J DALR_2 cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e CMS2_k127_398217_23 1449050.JNLE01000003_gene401 2.984e-05 52.0 2EFGV@1|root,3399G@2|Bacteria,1VHIS@1239|Firmicutes,24SXP@186801|Clostridia,36P84@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - CMS2_k127_398217_19 706434.HMPREF9429_00740 6.39e-15 75.0 COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,4H22P@909932|Negativicutes 909932|Negativicutes J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 CMS2_k127_4006221_61 1499967.BAYZ01000137_gene108 3.764e-18 85.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family yjoA - - - - - - - - - - - DinB,DinB_2 CMS2_k127_4006221_66 7091.BGIBMGA004547-TA 4.854e-06 56.0 KOG0613@1|root,KOG0613@2759|Eukaryota,38BAS@33154|Opisthokonta,3B9IR@33208|Metazoa,3CRJW@33213|Bilateria,41WSG@6656|Arthropoda,3SJC8@50557|Insecta,4438H@7088|Lepidoptera 33208|Metazoa T Immunoglobulin unc-22 GO:0003008,GO:0003012,GO:0003674,GO:0003779,GO:0003824,GO:0004672,GO:0004674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0005859,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006936,GO:0006937,GO:0006941,GO:0006942,GO:0006996,GO:0007010,GO:0007015,GO:0007498,GO:0007610,GO:0007626,GO:0008092,GO:0008150,GO:0008152,GO:0008307,GO:0008344,GO:0009636,GO:0009653,GO:0009888,GO:0009987,GO:0010638,GO:0010720,GO:0010927,GO:0015629,GO:0016043,GO:0016301,GO:0016310,GO:0016459,GO:0016460,GO:0016740,GO:0016772,GO:0016773,GO:0018105,GO:0018107,GO:0018193,GO:0018209,GO:0018210,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0022603,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030534,GO:0031032,GO:0031033,GO:0031034,GO:0031430,GO:0031672,GO:0031674,GO:0032501,GO:0032502,GO:0032956,GO:0032970,GO:0032989,GO:0032991,GO:0033043,GO:0034622,GO:0035094,GO:0035095,GO:0036211,GO:0040012,GO:0040017,GO:0042221,GO:0042493,GO:0042692,GO:0042805,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043412,GO:0043933,GO:0044057,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0044877,GO:0045214,GO:0045595,GO:0045597,GO:0045933,GO:0045989,GO:0048468,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051015,GO:0051094,GO:0051128,GO:0051130,GO:0051146,GO:0051147,GO:0051149,GO:0051153,GO:0051155,GO:0051239,GO:0051240,GO:0051302,GO:0051371,GO:0051393,GO:0051493,GO:0051495,GO:0051782,GO:0055001,GO:0055002,GO:0060284,GO:0060297,GO:0060298,GO:0061061,GO:0065003,GO:0065007,GO:0070925,GO:0071688,GO:0071689,GO:0071704,GO:0071840,GO:0090257,GO:0097435,GO:0097493,GO:0099080,GO:0099081,GO:0099512,GO:0110020,GO:0140096,GO:1901564,GO:1902115,GO:1902117,GO:1902903,GO:1902905 2.7.11.1 ko:K12567 ko05410,ko05414,map05410,map05414 - - - ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812 - - - I-set,Ig_3,Pkinase,fn3 CMS2_k127_4006221_68 113355.CM001775_gene779 0.0001348 45.0 COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,1G21K@1117|Cyanobacteria 1117|Cyanobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family nhaP - - - - - - - - - - iJN678.sll0556 Na_H_Exchanger,TrkA_N CMS2_k127_4006221_40 323261.Noc_0872 5.272e-86 296.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1WWM3@135613|Chromatiales 135613|Chromatiales S PFAM Alpha beta hydrolase - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4 CMS2_k127_4006221_13 566466.NOR53_1077 3.853e-192 612.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,1S1GU@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C CMS2_k127_4006221_49 138119.DSY0993 5.104e-53 201.0 COG1145@1|root,COG1145@2|Bacteria,1UIDU@1239|Firmicutes,25EIV@186801|Clostridia,267A7@186807|Peptococcaceae 186801|Clostridia C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - - CMS2_k127_4006221_56 401526.TcarDRAFT_2289 2.931e-35 144.0 2AV93@1|root,31M00@2|Bacteria,1V94N@1239|Firmicutes,4H7KF@909932|Negativicutes 909932|Negativicutes - - - - - - - - - - - - - - - CMS2_k127_4006221_57 335543.Sfum_3204 1.25e-30 128.0 COG2164@1|root,COG2164@2|Bacteria,1N81P@1224|Proteobacteria,430JJ@68525|delta/epsilon subdivisions,2WVQQ@28221|Deltaproteobacteria,2MRZH@213462|Syntrophobacterales 28221|Deltaproteobacteria S Cyclophilin-like - - - ko:K09143 - - - - ko00000 - - - Cyclophil_like CMS2_k127_4006221_48 880073.Calab_1047 1.629e-59 216.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety pagC - - ko:K07804 ko02020,map02020 - - - ko00000,ko00001 - - - Ail_Lom,OMP_b-brl CMS2_k127_4006221_55 880073.Calab_1046 1.206e-37 149.0 COG2353@1|root,COG2353@2|Bacteria 2|Bacteria O YceI-like domain - - - - - - - - - - - - YceI CMS2_k127_4006221_36 566466.NOR53_2256 4.347e-95 324.0 COG5505@1|root,COG5505@2|Bacteria,1MW87@1224|Proteobacteria,1RQPZ@1236|Gammaproteobacteria,1J6PZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Integral membrane protein - - - - - - - - - - - - DUF819 CMS2_k127_4006221_27 566466.NOR53_1394 7.889e-121 397.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RRQE@1236|Gammaproteobacteria,1JAP5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C CMS2_k127_4006221_18 1380394.JADL01000014_gene152 3.878e-166 531.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,2JQ78@204441|Rhodospirillales 204441|Rhodospirillales E Aminotransferase class-V - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 CMS2_k127_4006221_16 768706.Desor_4588 3.338e-167 537.0 COG2610@1|root,COG2610@2|Bacteria,1TQ14@1239|Firmicutes,248PQ@186801|Clostridia 186801|Clostridia EG Gluconate - - - ko:K03299 - - - - ko00000,ko02000 2.A.8 - - GntP_permease CMS2_k127_4006221_3 357808.RoseRS_3858 7.855e-259 828.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,376AA@32061|Chloroflexia 32061|Chloroflexia C FAD linked oxidase domain protein - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 CMS2_k127_4006221_39 472759.Nhal_2971 6.879e-87 290.0 COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1WWWB@135613|Chromatiales 135613|Chromatiales O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA CMS2_k127_4006221_2 1408473.JHXO01000005_gene1630 7.879e-264 829.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,2FN1K@200643|Bacteroidia 976|Bacteroidetes EU Peptidase, S9A B C family, catalytic domain protein pop GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - PD40,Peptidase_S9 CMS2_k127_4006221_21 1189612.A33Q_1369 2.064e-150 488.0 COG0006@1|root,COG0006@2|Bacteria,4NJI0@976|Bacteroidetes 976|Bacteroidetes E xaa-pro dipeptidase K01271 pepQ - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 CMS2_k127_4006221_42 344747.PM8797T_24516 1.541e-80 277.0 2AMSR@1|root,31CP7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_4006221_26 1123073.KB899244_gene364 4.347e-122 414.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RRWF@1236|Gammaproteobacteria,1X4FU@135614|Xanthomonadales 135614|Xanthomonadales S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 CMS2_k127_4006221_6 518766.Rmar_0629 1.448e-228 744.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes MU WD40-like Beta Propeller Repeat - - - - - - - - - - - - BSP,Bac_surface_Ag,PD40 CMS2_k127_4006221_41 384765.SIAM614_24197 4.481e-82 287.0 COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2VGKD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS2_k127_4006221_47 861299.J421_0491 1.778e-61 233.0 2EZKR@1|root,33SRW@2|Bacteria,1ZSQ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4006221_34 861299.J421_1115 6.148e-97 327.0 COG0457@1|root,COG0457@2|Bacteria,1ZTCW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - - CMS2_k127_4006221_67 338963.Pcar_1476 4.708e-05 49.0 28N9P@1|root,2ZBDN@2|Bacteria,1R70P@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3592) - - - - - - - - - - - - DUF3592 CMS2_k127_4006221_44 861299.J421_0340 7.105e-66 240.0 COG3595@1|root,COG3595@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4097,PA14 CMS2_k127_4006221_65 1380394.JADL01000005_gene5374 2.176e-07 59.0 COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria,2JPVC@204441|Rhodospirillales 204441|Rhodospirillales G Malonyl-CoA decarboxylase N-terminal domain - - 4.1.1.9 ko:K01578 ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152 - R00233 RC00040 ko00000,ko00001,ko01000 - - - MCD,MCD_N CMS2_k127_4006221_28 1547437.LL06_15680 6.537e-109 366.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 CMS2_k127_4006221_15 926569.ANT_04950 2.305e-169 541.0 COG0183@1|root,COG0183@2|Bacteria,2G5YW@200795|Chloroflexi 200795|Chloroflexi I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N CMS2_k127_4006221_38 485913.Krac_10666 2.635e-91 317.0 COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi 2|Bacteria E aminotransferase class I and II aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_4006221_45 861299.J421_3045 2.111e-64 241.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 861299.J421_3045|- KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_4006221_50 765869.BDW_04525 2.952e-50 184.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,42SRT@68525|delta/epsilon subdivisions,2MT17@213481|Bdellovibrionales,2WPB8@28221|Deltaproteobacteria 213481|Bdellovibrionales S EVE domain - - - - - - - - - - - - EVE CMS2_k127_4006221_54 2074.JNYD01000008_gene1243 1.316e-38 164.0 COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria,4E1H2@85010|Pseudonocardiales 201174|Actinobacteria S Immune inhibitor A peptidase M6 - - - ko:K09607 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M6 CMS2_k127_4006221_10 926550.CLDAP_16590 1.202e-205 647.0 COG2403@1|root,COG2403@2|Bacteria,2G7VS@200795|Chloroflexi 200795|Chloroflexi S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - - CMS2_k127_4006221_8 1232410.KI421412_gene169 1.253e-209 658.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,43SYA@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK CMS2_k127_4006221_30 485916.Dtox_1611 2.414e-101 338.0 COG0535@1|root,COG0535@2|Bacteria,1URM8@1239|Firmicutes,24XB8@186801|Clostridia 186801|Clostridia C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM CMS2_k127_4006221_51 335543.Sfum_0229 1.419e-49 183.0 COG0778@1|root,COG0778@2|Bacteria,1RJMP@1224|Proteobacteria,43BDS@68525|delta/epsilon subdivisions,2X6SC@28221|Deltaproteobacteria,2MS1B@213462|Syntrophobacterales 28221|Deltaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase CMS2_k127_4006221_58 694431.DESACE_06835 4.675e-30 124.0 COG1545@1|root,COG1545@2|Bacteria 2|Bacteria I DUF35 OB-fold domain, acyl-CoA-associated phlB - - ko:K07068,ko:K07549 ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220 M00418 R05587 RC00004,RC01428,RC02904 ko00000,ko00001,ko00002,ko01000 - - - DUF35_N,OB_aCoA_assoc CMS2_k127_4006221_24 1094980.Mpsy_1639 2.861e-134 439.0 COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia 224756|Methanomicrobia I PFAM Thiolase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAF692.Mbar_A0550 Thiolase_C,Thiolase_N CMS2_k127_4006221_25 386456.JQKN01000002_gene2485 8.875e-130 422.0 COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23NSI@183925|Methanobacteria 183925|Methanobacteria I Belongs to the UPF0219 family - - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - ACP_syn_III_C,HMG_CoA_synt_N CMS2_k127_4006221_20 1047013.AQSP01000098_gene2568 2.074e-155 518.0 COG1042@1|root,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria 2|Bacteria C synthetase (ADP forming), alpha - - 6.2.1.13 ko:K01905,ko:K09181,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig CMS2_k127_4006221_9 1121920.AUAU01000021_gene2509 2.877e-209 659.0 COG0674@1|root,COG0674@2|Bacteria,3Y3NB@57723|Acidobacteria 57723|Acidobacteria C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.7 ko:K00186 ko00280,ko01100,map00280,map01100 - R07160,R08566,R08567 RC00004,RC02833,RC02856 br01601,ko00000,ko00001,ko01000 - - - PFOR_II,POR_N CMS2_k127_4006221_11 1121920.AUAU01000021_gene2510 1.193e-204 646.0 COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,3Y3G3@57723|Acidobacteria 57723|Acidobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.7 ko:K00187 ko00280,ko01100,map00280,map01100 - R07160,R08566,R08567 RC00004,RC02833,RC02856 br01601,ko00000,ko00001,ko01000 - - - POR,TPP_enzyme_C CMS2_k127_4006221_33 1191523.MROS_2406 2.387e-97 330.0 COG0686@1|root,COG0686@2|Bacteria 2|Bacteria E alanine dehydrogenase activity ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N CMS2_k127_4006221_17 1123386.AUIW01000010_gene96 8.649e-167 546.0 COG0427@1|root,COG0427@2|Bacteria,1WJIT@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro CMS2_k127_4006221_23 580340.Tlie_1655 1.589e-139 449.0 COG0451@1|root,COG0451@2|Bacteria,3T9U6@508458|Synergistetes 508458|Synergistetes M NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase CMS2_k127_4006221_19 1121104.AQXH01000001_gene1630 3.34e-161 519.0 COG0624@1|root,COG0624@2|Bacteria,4NJN0@976|Bacteroidetes,1IP8H@117747|Sphingobacteriia 976|Bacteroidetes E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS2_k127_4006221_46 1429916.X566_21810 4.039e-63 226.0 COG1024@1|root,COG1024@2|Bacteria,1RAAV@1224|Proteobacteria,2UB9Y@28211|Alphaproteobacteria,3JXKA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS2_k127_4006221_64 335543.Sfum_2441 3.441e-10 64.0 299YV@1|root,2ZX0J@2|Bacteria,1P75H@1224|Proteobacteria,432SS@68525|delta/epsilon subdivisions,2WY0Q@28221|Deltaproteobacteria,2MSEU@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4006221_52 1047013.AQSP01000091_gene641 6.235e-45 174.0 COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria 2|Bacteria C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx CMS2_k127_4006221_1 1047013.AQSP01000091_gene642 0.0 1083.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain sfrB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944 1.12.1.3,1.17.1.10,1.6.5.3 ko:K00335,ko:K15022,ko:K18331 ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200 M00144,M00377 R00134,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_2080 2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB CMS2_k127_4006221_43 1047013.AQSP01000091_gene643 9.681e-78 267.0 COG3383@1|root,COG3383@2|Bacteria,2NNXH@2323|unclassified Bacteria 2|Bacteria C Iron hydrogenase small subunit - - 1.12.1.3,1.17.1.9,1.6.5.3 ko:K00123,ko:K00336,ko:K18332 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - iHN637.CLJU_RS03470 Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_21,Fer4_7,NADH-G_4Fe-4S_3 CMS2_k127_4006221_5 1047013.AQSP01000091_gene644 1.616e-233 733.0 COG1304@1|root,COG1304@2|Bacteria 2|Bacteria C FMN binding yahG - - - - - - - - - - - DUF1116,FMN_dh,Glu_synthase CMS2_k127_4006221_35 909663.KI867150_gene970 5.261e-96 336.0 COG4191@1|root,COG4191@2|Bacteria,1R89N@1224|Proteobacteria,42QDX@68525|delta/epsilon subdivisions,2WKNA@28221|Deltaproteobacteria,2MR83@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS CMS2_k127_4006221_14 909663.KI867150_gene971 2.056e-171 550.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X1VS@28221|Deltaproteobacteria,2MRES@213462|Syntrophobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_4006221_37 67373.JOBF01000001_gene6311 1.851e-93 312.0 COG0602@1|root,COG0602@2|Bacteria,2I9R3@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM CMS2_k127_4006221_31 215803.DB30_7393 2.668e-100 332.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2Z04D@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_3075 QueC CMS2_k127_4006221_53 644966.Tmar_2124 1.559e-40 154.0 COG0780@1|root,COG0780@2|Bacteria,1TPYC@1239|Firmicutes,24BYP@186801|Clostridia,3WDJ3@538999|Clostridiales incertae sedis 186801|Clostridia S QueF-like protein queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF CMS2_k127_4006221_29 1499967.BAYZ01000119_gene3214 5.025e-103 346.0 COG2129@1|root,COG2129@2|Bacteria 2|Bacteria L metallophosphoesterase - - - ko:K07096 - - - - ko00000 - - - Metallophos,Metallophos_2,Metallophos_3 CMS2_k127_4006221_0 1191523.MROS_2798 0.0 1130.0 COG0574@1|root,COG0574@2|Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_2,PPDK_N,Response_reg CMS2_k127_4006221_12 1499967.BAYZ01000119_gene3216 1.549e-201 645.0 COG0574@1|root,COG0574@2|Bacteria,2NQHP@2323|unclassified Bacteria 2|Bacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_2,PPDK_N,Response_reg CMS2_k127_4006221_7 1499967.BAYZ01000081_gene1057 6.626e-214 670.0 COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria 2|Bacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gluD GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.gdhA ELFV_dehydrog,ELFV_dehydrog_N CMS2_k127_4006221_32 861299.J421_3926 1.184e-99 343.0 COG2027@1|root,COG2027@2|Bacteria,1ZSQ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M D-Ala-D-Ala carboxypeptidase 3 (S13) family - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 CMS2_k127_4006221_4 565045.NOR51B_1262 1.913e-245 775.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RR88@1236|Gammaproteobacteria,1J5WK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - PD40,Peptidase_S9 CMS2_k127_4006221_60 379066.GAU_1908 9.274e-20 96.0 COG5608@1|root,COG5608@2|Bacteria,1ZTWB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Late embryogenesis abundant protein - - - - - - - - - - - - LEA_2 CMS2_k127_4006221_22 472759.Nhal_0820 8.4e-149 479.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1WX09@135613|Chromatiales 135613|Chromatiales P cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C CMS2_k127_4006221_63 1367847.JCM7686_1010 2.84e-11 66.0 2DI20@1|root,301S0@2|Bacteria,1NHCQ@1224|Proteobacteria,2V5MT@28211|Alphaproteobacteria,2PZ01@265|Paracoccus 28211|Alphaproteobacteria S Transcriptional Coactivator p15 (PC4) - - - - - - - - - - - - PC4 CMS2_k127_4039559_6 864051.BurJ1DRAFT_3712 1.273e-134 441.0 COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2VSCS@28216|Betaproteobacteria,1KP2Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria C B12 binding domain - - 1.21.98.3 ko:K04034 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06268,R06269,R06270 RC00741,RC01491,RC01492 ko00000,ko00001,ko01000 - - - B12-binding,Radical_SAM CMS2_k127_4039559_0 616991.JPOO01000003_gene151 1.5e-241 785.0 COG0457@1|root,COG0457@2|Bacteria,4NIBU@976|Bacteroidetes,1HZ35@117743|Flavobacteriia,23I14@178469|Arenibacter 976|Bacteroidetes S Domain of unknown function (DUF5107) - - - - - - - - - - - - DUF5107,TPR_16,TPR_8 CMS2_k127_4039559_2 1265505.ATUG01000002_gene1969 1.623e-189 599.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2MIV2@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth CMS2_k127_4039559_21 945713.IALB_0238 2.271e-26 111.0 COG4274@1|root,COG4274@2|Bacteria 2|Bacteria S GYD domain - - - - - - - - - - - - GYD CMS2_k127_4039559_24 552811.Dehly_1153 2.199e-10 63.0 2EFVW@1|root,339N3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_4039559_8 404589.Anae109_3957 8.726e-108 364.0 COG0312@1|root,COG0312@2|Bacteria,1RBJZ@1224|Proteobacteria,42YBE@68525|delta/epsilon subdivisions,2WUP7@28221|Deltaproteobacteria,2YZ4Y@29|Myxococcales 28221|Deltaproteobacteria L Putative modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD CMS2_k127_4039559_3 1192034.CAP_6731 1.947e-169 548.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42Y66@68525|delta/epsilon subdivisions,2WU83@28221|Deltaproteobacteria,2YX71@29|Myxococcales 28221|Deltaproteobacteria S Putative modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD CMS2_k127_4039559_4 861299.J421_1382 9.502e-165 531.0 COG1228@1|root,COG1228@2|Bacteria,1ZSME@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS2_k127_4039559_19 1232410.KI421412_gene441 3.549e-29 119.0 COG3809@1|root,COG3809@2|Bacteria,1Q8Z4@1224|Proteobacteria,42UTF@68525|delta/epsilon subdivisions,2WXCZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Transcription factor zinc-finger - - - ko:K09981 - - - - ko00000 - - - zf-TFIIB CMS2_k127_4039559_5 880073.Calab_1713 4.709e-144 471.0 COG1660@1|root,COG3178@1|root,COG1660@2|Bacteria,COG3178@2|Bacteria,2NP9G@2323|unclassified Bacteria 2|Bacteria S P-loop ATPase protein family - GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 ko:K06958,ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000,ko03019 - - - APH,ATP_bind_2 CMS2_k127_4039559_13 1499967.BAYZ01000074_gene2167 3.848e-47 182.0 COG1208@1|root,COG1208@2|Bacteria,2NQWZ@2323|unclassified Bacteria 2|Bacteria JM Nucleotidyl transferase hddC - 2.7.7.13,2.7.7.24 ko:K00966,ko:K00973 ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130 M00114,M00361,M00362,M00793 R00885,R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - APH,NTP_transferase CMS2_k127_4039559_10 861299.J421_1261 6.977e-88 306.0 COG0612@1|root,COG0612@2|Bacteria,1ZT7N@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase M16 inactive domain - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16_C CMS2_k127_4039559_11 379066.GAU_0129 5.386e-73 264.0 COG0612@1|root,COG0612@2|Bacteria,1ZT1J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_4039559_22 755732.Fluta_0605 2.141e-24 113.0 COG3291@1|root,COG3291@2|Bacteria,4NM0P@976|Bacteroidetes,1I0CF@117743|Flavobacteriia,2PAUX@246874|Cryomorphaceae 976|Bacteroidetes S PFAM PKD domain - - - - - - - - - - - - PKD,Peptidase_M14 CMS2_k127_4039559_23 913325.N799_13960 3.282e-14 82.0 COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,1RP7T@1236|Gammaproteobacteria,1X44K@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF541) - - - ko:K09807 - - - - ko00000 - - - SIMPL CMS2_k127_4039559_18 298653.Franean1_3948 7.818e-31 136.0 COG3568@1|root,COG3568@2|Bacteria,2IGGC@201174|Actinobacteria,4EVQ7@85013|Frankiales 201174|Actinobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos CMS2_k127_4039559_16 56780.SYN_01067 1.907e-32 130.0 COG0662@1|root,COG0662@2|Bacteria,1QUHG@1224|Proteobacteria,43BPC@68525|delta/epsilon subdivisions,2X70P@28221|Deltaproteobacteria,2MS6I@213462|Syntrophobacterales 28221|Deltaproteobacteria G Cupin domain - - - ko:K11312 - - - - ko00000 - - - Cupin_2 CMS2_k127_4039559_9 583355.Caka_0541 9.378e-92 313.0 COG0363@1|root,COG0363@2|Bacteria,46TGA@74201|Verrucomicrobia,3K82B@414999|Opitutae 414999|Opitutae G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase - - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso,PIG-L CMS2_k127_4039559_1 649638.Trad_0128 3.186e-213 672.0 COG3333@1|root,COG3333@2|Bacteria,1WIRN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA CMS2_k127_4039559_20 869210.Marky_0165 6.509e-27 116.0 2CQ1K@1|root,330SJ@2|Bacteria,1WKKB@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM Tripartite tricarboxylate transporter TctB family - - - ko:K07794 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctB CMS2_k127_4039559_7 670487.Ocepr_0061 2.055e-109 362.0 COG3181@1|root,COG3181@2|Bacteria,1WJNT@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM Tripartite tricarboxylate transporter family receptor - - - ko:K07795 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctC CMS2_k127_4039559_15 555779.Dthio_PD3360 1.921e-34 147.0 COG4852@1|root,COG4852@2|Bacteria,1MZHP@1224|Proteobacteria,42TD7@68525|delta/epsilon subdivisions,2WPIH@28221|Deltaproteobacteria,2MF5C@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2177) - - - - - - - - - - - - DUF2177 CMS2_k127_4039559_14 1121887.AUDK01000002_gene2156 8.295e-45 167.0 COG3476@1|root,COG3476@2|Bacteria,4NP0D@976|Bacteroidetes,1I2B8@117743|Flavobacteriia,2NVX1@237|Flavobacterium 976|Bacteroidetes T TspO/MBR family tspO - - ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 - - - ko00000,ko00001,ko02000 9.A.24 - - TspO_MBR CMS2_k127_4039559_25 1144313.PMI10_03194 7.483e-09 64.0 2DYAV@1|root,348Z2@2|Bacteria,4P6DA@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_4039559_12 1121918.ARWE01000001_gene3202 3.282e-53 192.0 2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,43UWE@69541|Desulfuromonadales 28221|Deltaproteobacteria S Yip1 domain - - - - - - - - - - - - Yip1 CMS2_k127_4111829_3 1267535.KB906767_gene5029 2.165e-27 114.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_4111829_1 706587.Desti_0623 1.239e-47 180.0 COG0500@1|root,COG2226@2|Bacteria,1R5JA@1224|Proteobacteria,42Q5Z@68525|delta/epsilon subdivisions,2WM80@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 CMS2_k127_4111829_4 1163409.UUA_13235 1.312e-08 61.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1X98R@135614|Xanthomonadales 135614|Xanthomonadales G Cellobiose phosphorylase - - - ko:K13688 - - - - ko00000,ko01000,ko01003 - GH94,GT84 - Glyco_hydro_36,Glyco_transf_36 CMS2_k127_4111829_0 595537.Varpa_3623 2.548e-96 332.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,4AAFY@80864|Comamonadaceae 28216|Betaproteobacteria H MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N CMS2_k127_4111829_2 107635.AZUO01000003_gene4133 8.393e-28 117.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,2TVN2@28211|Alphaproteobacteria 28211|Alphaproteobacteria HP TIGRFAM molybdenum cofactor synthesis domain MA20_10225 - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like CMS2_k127_4112589_2 324057.Pjdr2_5219 4.111e-48 177.0 COG1123@1|root,COG4172@2|Bacteria,1UZK8@1239|Firmicutes,4HTUD@91061|Bacilli,277AG@186822|Paenibacillaceae 91061|Bacilli P Belongs to the ABC transporter superfamily oppF - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY CMS2_k127_4112589_1 861299.J421_2679 1.13e-98 338.0 COG4608@1|root,COG4608@2|Bacteria,1ZSTB@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY CMS2_k127_4112589_4 1229172.JQFA01000002_gene3488 2.007e-07 55.0 COG2250@1|root,COG2250@2|Bacteria,1GHK1@1117|Cyanobacteria,1HGU7@1150|Oscillatoriales 1117|Cyanobacteria S HEPN domain - - - - - - - - - - - - HEPN CMS2_k127_4112589_3 289376.THEYE_A2049 1.194e-16 86.0 COG1708@1|root,COG1708@2|Bacteria 2|Bacteria S nucleotidyltransferase activity - - - ko:K07076 - - - - ko00000 - - - NTP_transf_2 CMS2_k127_4112589_0 861299.J421_5850 5.645e-119 400.0 COG3975@1|root,COG3975@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PDZ_2,Peptidase_M61 CMS2_k127_412891_1 566466.NOR53_670 7.951e-188 602.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1J7SK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 CMS2_k127_412891_4 861299.J421_1682 2.875e-43 183.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 2|Bacteria T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS2_k127_412891_9 1122931.AUAE01000040_gene2818 1.703e-05 56.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,2FWS8@200643|Bacteroidia,231P8@171551|Porphyromonadaceae 976|Bacteroidetes P CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec CMS2_k127_412891_0 861299.J421_2004 3.013e-236 758.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZTB3@142182|Gemmatimonadetes 142182|Gemmatimonadetes EU Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 CMS2_k127_412891_3 861299.J421_2212 2.257e-56 201.0 COG0742@1|root,COG0742@2|Bacteria,1ZTNJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Conserved hypothetical protein 95 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 CMS2_k127_412891_2 177437.HRM2_33750 2.1e-162 531.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MJNF@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N CMS2_k127_412891_5 177437.HRM2_33760 1.295e-30 126.0 COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,42TQV@68525|delta/epsilon subdivisions,2WQAE@28221|Deltaproteobacteria,2MKXW@213118|Desulfobacterales 1224|Proteobacteria C 4Fe-4S dicluster domain ygfS GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 - ko:K05796 - - - - ko00000 - - - Fer4,Fer4_11,Fer4_4,Fer4_6,Fer4_7,Fer4_9 CMS2_k127_412891_6 264732.Moth_0153 4.362e-22 106.0 COG1142@1|root,COG1142@2|Bacteria,1VH83@1239|Firmicutes,24TVN@186801|Clostridia,42JCX@68295|Thermoanaerobacterales 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_4,Fer4_7 CMS2_k127_412891_7 891968.Anamo_1967 1.238e-20 102.0 COG1142@1|root,COG1142@2|Bacteria,3TCIW@508458|Synergistetes 508458|Synergistetes C 4Fe-4S dicluster domain - - - - - - - - - - - - - CMS2_k127_413379_9 234267.Acid_7563 1.183e-115 402.0 COG0577@1|root,COG0577@2|Bacteria,3Y64Z@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_413379_18 861299.J421_6358 8.34e-33 130.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_413379_10 382464.ABSI01000010_gene3557 2.107e-107 357.0 COG4152@1|root,COG4152@2|Bacteria 2|Bacteria S ATPase activity natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 CMS2_k127_413379_13 382464.ABSI01000010_gene3558 1.847e-70 256.0 COG1668@1|root,COG1668@2|Bacteria 2|Bacteria CP transmembrane transport natB - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS2_k127_413379_4 861299.J421_1760 6.019e-147 502.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_413379_19 485913.Krac_5098 1.331e-30 125.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_413379_12 1121939.L861_18905 5.28e-72 247.0 COG1628@1|root,COG1628@2|Bacteria,1RCX1@1224|Proteobacteria,1S7VS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function DUF99 - - - ko:K09120 - - - - ko00000 - - - DUF99 CMS2_k127_413379_24 472759.Nhal_1932 6.994e-17 83.0 2E7PS@1|root,3325B@2|Bacteria 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - CMS2_k127_413379_20 1173020.Cha6605_0163 3.706e-30 123.0 COG3695@1|root,COG3695@2|Bacteria,1G82G@1117|Cyanobacteria 1117|Cyanobacteria L Methylated dna-protein cysteine methyltransferase - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 CMS2_k127_413379_3 1144275.COCOR_03147 2.887e-161 520.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,4360M@68525|delta/epsilon subdivisions,2X2HZ@28221|Deltaproteobacteria,2Z0WC@29|Myxococcales 28221|Deltaproteobacteria E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS2_k127_413379_5 525904.Tter_1717 2.461e-142 465.0 COG0160@1|root,COG0160@2|Bacteria,2NNRV@2323|unclassified Bacteria 2|Bacteria E Aminotransferase class-III lat - 2.6.1.11,2.6.1.17,2.6.1.19,2.6.1.22,2.6.1.33,2.6.1.36 ko:K00821,ko:K03918,ko:K07250,ko:K13524,ko:K20428 ko00220,ko00250,ko00280,ko00300,ko00410,ko00525,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,ko04727,map00220,map00250,map00280,map00300,map00410,map00525,map00640,map00650,map01100,map01110,map01120,map01130,map01210,map01230,map04727 M00016,M00027,M00028,M00845 R00457,R00908,R01648,R02283,R02773,R04188,R04475 RC00006,RC00062,RC00160,RC00781 ko00000,ko00001,ko00002,ko01000,ko01007 - - iNJ661.Rv3290c Aminotran_3 CMS2_k127_413379_15 639282.DEFDS_1384 1.056e-65 244.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1 CMS2_k127_413379_6 644283.Micau_2143 5.448e-140 468.0 COG2303@1|root,COG2303@2|Bacteria,2GJKS@201174|Actinobacteria 201174|Actinobacteria E Oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3 CMS2_k127_413379_26 589865.DaAHT2_2110 3.58e-13 82.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Cytochrome_C554,Multi-haem_cyto,Paired_CXXCH_1 CMS2_k127_413379_8 880073.Calab_1599 1.503e-135 454.0 COG2864@1|root,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria 2|Bacteria C Cytochrome b subunit of formate dehydrogenase-like protein - - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS2_k127_413379_0 1379698.RBG1_1C00001G0777 0.0 1048.0 COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria 2|Bacteria P Prokaryotic cytochrome b561 cbcY - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese CMS2_k127_413379_21 1242864.D187_009505 8.137e-28 125.0 COG3303@1|root,COG3303@2|Bacteria,1MYBV@1224|Proteobacteria,42SER@68525|delta/epsilon subdivisions,2WPC2@28221|Deltaproteobacteria,2YUR5@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 CMS2_k127_413379_27 1458462.JNLK01000001_gene912 2.714e-08 66.0 COG1040@1|root,COG1040@2|Bacteria,1UJJJ@1239|Firmicutes 1239|Firmicutes S Double zinc ribbon - - - - - - - - - - - - DZR,zinc_ribbon_2 CMS2_k127_413379_16 504472.Slin_6199 5.277e-54 194.0 COG1670@1|root,COG1670@2|Bacteria,4NQB5@976|Bacteroidetes,47XD5@768503|Cytophagia 976|Bacteroidetes J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 CMS2_k127_413379_14 187272.Mlg_0922 2.527e-69 239.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1WYD7@135613|Chromatiales 135613|Chromatiales O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase CMS2_k127_413379_7 1173026.Glo7428_3972 1.025e-139 459.0 COG0531@1|root,COG0531@2|Bacteria,1G2VF@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease,AA_permease_2 CMS2_k127_413379_28 1304872.JAGC01000007_gene2253 5.074e-05 55.0 COG0457@1|root,COG1388@1|root,COG0457@2|Bacteria,COG1388@2|Bacteria,1PF8E@1224|Proteobacteria,4328Y@68525|delta/epsilon subdivisions,2WYE8@28221|Deltaproteobacteria,2M966@213115|Desulfovibrionales 28221|Deltaproteobacteria M Tetratricopeptide repeat - - - - - - - - - - - - LysM,TPR_1,TPR_16,TPR_8 CMS2_k127_413379_11 264732.Moth_0703 7.661e-91 314.0 COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia,42I51@68295|Thermoanaerobacterales 186801|Clostridia J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B CMS2_k127_413379_2 526227.Mesil_1029 9.113e-176 564.0 COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N CMS2_k127_413379_17 861299.J421_2741 5.965e-48 175.0 COG2332@1|root,COG2332@2|Bacteria,1ZTNV@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH - - - ko:K02197 - - - - ko00000 - - - CcmE CMS2_k127_413379_1 379066.GAU_0820 2.86e-252 796.0 COG1138@1|root,COG1138@2|Bacteria,1ZTBY@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome c-type biogenesis protein CcmF C-terminal - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm CMS2_k127_413379_22 861299.J421_2743 4.419e-23 106.0 COG3088@1|root,COG3088@2|Bacteria,1ZTS7@142182|Gemmatimonadetes 142182|Gemmatimonadetes P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH CMS2_k127_413379_23 861299.J421_2744 1.885e-20 97.0 29W2Z@1|root,30HMM@2|Bacteria,1ZTXQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4167218_7 1121875.KB907548_gene1518 3.057e-18 98.0 2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1HZN8@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 CMS2_k127_4167218_6 861299.J421_0442 1.437e-22 105.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_4167218_4 518766.Rmar_0978 2.102e-33 150.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,1FIJ6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_4167218_2 1121930.AQXG01000008_gene175 1.312e-110 373.0 COG4826@1|root,COG4826@2|Bacteria,4NG1G@976|Bacteroidetes,1IRRU@117747|Sphingobacteriia 976|Bacteroidetes O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin CMS2_k127_4167218_0 575540.Isop_2571 6.142e-153 491.0 COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes 203682|Planctomycetes P COG0798 Arsenite efflux pump ACR3 and related - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF CMS2_k127_4167218_5 269796.Rru_A1450 1.307e-22 104.0 COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,1MWYQ@1224|Proteobacteria,2TU1U@28211|Alphaproteobacteria,2JS9P@204441|Rhodospirillales 204441|Rhodospirillales T Belongs to the low molecular weight phosphotyrosine protein phosphatase family - - 1.20.4.1 ko:K03741,ko:K03892 - - - - ko00000,ko01000,ko03000 - - - HTH_20,LMWPc CMS2_k127_4167218_1 1121875.KB907546_gene2757 1.543e-118 390.0 COG1082@1|root,COG1082@2|Bacteria,4NG1K@976|Bacteroidetes,1HYV9@117743|Flavobacteriia 976|Bacteroidetes G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 CMS2_k127_4167218_8 379066.GAU_2497 0.0009972 48.0 2C0MY@1|root,30KW5@2|Bacteria,1ZTVN@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4167218_3 105422.BBPM01000078_gene66 4.04e-64 237.0 COG2730@1|root,COG3291@1|root,COG3420@1|root,COG2730@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,2I41P@201174|Actinobacteria,2NNHT@228398|Streptacidiphilus 201174|Actinobacteria G Carbohydrate binding domain - - - - - - - - - - - - Beta_helix,CBM_4_9 CMS2_k127_421100_11 1123399.AQVE01000030_gene1358 1.077e-09 60.0 2EG09@1|root,339SB@2|Bacteria,1NJCW@1224|Proteobacteria,1SH7A@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_421100_9 1193181.BN10_1300016 7.326e-30 126.0 2DSQW@1|root,33H3S@2|Bacteria,2GTIV@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - CMS2_k127_421100_7 1123276.KB893312_gene3006 1.217e-57 214.0 28M5H@1|root,2ZAJ9@2|Bacteria,4NESS@976|Bacteroidetes,47NNA@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_421100_1 338966.Ppro_2689 7.052e-230 743.0 COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,42M4M@68525|delta/epsilon subdivisions,2WIPI@28221|Deltaproteobacteria,43SU8@69541|Desulfuromonadales 28221|Deltaproteobacteria S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 CMS2_k127_421100_8 314278.NB231_00999 1.48e-33 131.0 COG1522@1|root,COG1522@2|Bacteria,1NC1H@1224|Proteobacteria,1SE9N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional - - - - - - - - - - - - AsnC_trans_reg CMS2_k127_421100_2 880073.Calab_0498 1.303e-130 424.0 COG0332@1|root,COG0332@2|Bacteria,2NQDW@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180,2.3.1.262 ko:K00648,ko:K18003 ko00061,ko00405,ko01100,ko01130,ko01212,ko02024,ko02025,map00061,map00405,map01100,map01130,map01212,map02024,map02025 M00082,M00083 R10707,R11586,R11587,R11588 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C CMS2_k127_421100_6 861299.J421_0787 2.42e-63 227.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS2_k127_421100_4 1191523.MROS_0148 2.728e-93 321.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - ko:K22110 - - - - ko00000,ko02000 1.B.35.1,1.B.35.2 - - MtrB_PioB,OMP_b-brl,OMP_b-brl_2 CMS2_k127_421100_5 861299.J421_2098 6.629e-68 243.0 28M5H@1|root,2ZAJ9@2|Bacteria,1ZUWX@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_421100_3 861299.J421_0867 5.971e-124 430.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_0867|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_421100_0 941449.dsx2_0363 0.0 1236.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2M9PX@213115|Desulfovibrionales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran CMS2_k127_4246796_2 861299.J421_2746 6.065e-08 59.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_4246796_1 234267.Acid_2305 4.675e-26 110.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZC@57723|Acidobacteria 57723|Acidobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR CMS2_k127_4246796_0 1379270.AUXF01000007_gene1012 4.576e-317 1002.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Sortilin-Vps10 CMS2_k127_4246796_3 1219035.NT2_08_01360 2.077e-07 52.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2K2HE@204457|Sphingomonadales 204457|Sphingomonadales L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom CMS2_k127_4247681_4 344747.PM8797T_08689 4.204e-78 269.0 COG1028@1|root,COG1028@2|Bacteria,2IZC3@203682|Planctomycetes 203682|Planctomycetes IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short_C2 CMS2_k127_4247681_5 194439.CT2221 8.813e-39 155.0 COG0705@1|root,COG0705@2|Bacteria,1FDF1@1090|Chlorobi 1090|Chlorobi S PFAM Rhomboid family protein - - - - - - - - - - - - Rhomboid CMS2_k127_4247681_2 1232410.KI421424_gene1795 7.806e-91 305.0 COG0637@1|root,COG0637@2|Bacteria 2|Bacteria S phosphonoacetaldehyde hydrolase activity pgmB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576 2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6 ko:K01087,ko:K01194,ko:K01838,ko:K05342 ko00500,ko01100,map00500,map01100 - R00010,R02727,R02728,R02778,R11310 RC00017,RC00049,RC00408 ko00000,ko00001,ko00537,ko01000 - GH37,GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase,Trehalose_PPase CMS2_k127_4247681_3 1121943.KB899993_gene235 1.737e-85 296.0 COG0637@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,1RNIQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495 Trehalose_PPase CMS2_k127_4247681_0 232721.Ajs_2162 5e-324 1009.0 COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,2VK07@28216|Betaproteobacteria 28216|Betaproteobacteria G Glycosyl hydrolase family 65 central catalytic domain protein - - 2.4.1.64,2.4.1.8 ko:K00691,ko:K05342 ko00500,ko01100,map00500,map01100 - R01555,R02727 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m CMS2_k127_4247681_1 861299.J421_3809 3.166e-213 677.0 COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase CMS2_k127_4247681_6 690850.Desaf_3395 4.237e-18 90.0 COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,42MEW@68525|delta/epsilon subdivisions,2WJX1@28221|Deltaproteobacteria,2M8X0@213115|Desulfovibrionales 28221|Deltaproteobacteria G TIGRFAM Malto-oligosyltrehalose synthase treY - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase CMS2_k127_4248943_8 1449076.JOOE01000004_gene325 5.827e-63 235.0 COG2021@1|root,COG2021@2|Bacteria,1R32W@1224|Proteobacteria,2TZX3@28211|Alphaproteobacteria,2KEVZ@204457|Sphingomonadales 2|Bacteria E alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 CMS2_k127_4248943_17 1121949.AQXT01000002_gene2910 2.061e-07 59.0 COG4319@1|root,COG4319@2|Bacteria,1PZUG@1224|Proteobacteria,2V19B@28211|Alphaproteobacteria,44001@69657|Hyphomonadaceae 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS2_k127_4248943_15 1230460.C495_13331 1.554e-14 81.0 COG0346@1|root,arCOG02706@2157|Archaea,2XUR5@28890|Euryarchaeota,23UU2@183963|Halobacteria 183963|Halobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase_4 CMS2_k127_4248943_19 62928.azo1967 0.0008 48.0 2AXN4@1|root,31PNF@2|Bacteria,1RK4Y@1224|Proteobacteria,2VSUK@28216|Betaproteobacteria,2KWQJ@206389|Rhodocyclales 206389|Rhodocyclales S Lipocalin-like domain - - - - - - - - - - - - Lipocalin_5 CMS2_k127_4248943_18 1121931.AUHG01000012_gene2925 0.0006651 43.0 COG1917@1|root,COG1917@2|Bacteria,4P2XE@976|Bacteroidetes,1IAY3@117743|Flavobacteriia 976|Bacteroidetes S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - CMS2_k127_4248943_13 391625.PPSIR1_26558 1.066e-19 89.0 COG3183@1|root,COG3183@2|Bacteria,1PKMN@1224|Proteobacteria,43553@68525|delta/epsilon subdivisions,2X95P@28221|Deltaproteobacteria,2Z22J@29|Myxococcales 28221|Deltaproteobacteria L HNH nucleases - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - HNH CMS2_k127_4248943_7 1379698.RBG1_1C00001G0858 5.244e-84 293.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C CMS2_k127_4248943_6 1379698.RBG1_1C00001G0858 1.473e-86 300.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C CMS2_k127_4248943_0 1379698.RBG1_1C00001G0857 4.725e-149 486.0 COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria 1379698.RBG1_1C00001G0857|- C Polysulphide reductase, NrfD - - - - - - - - - - - - - CMS2_k127_4248943_5 1379698.RBG1_1C00001G0856 7.771e-98 324.0 COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7 CMS2_k127_4248943_3 1379698.RBG1_1C00001G0855 1.08e-123 426.0 COG0243@1|root,COG0243@2|Bacteria,2NPRJ@2323|unclassified Bacteria 2|Bacteria C Molydopterin dinucleotide binding domain qrcB - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS2_k127_4248943_12 338963.Pcar_2550 1.534e-22 105.0 COG3303@1|root,COG3303@2|Bacteria,1QY22@1224|Proteobacteria,43C9D@68525|delta/epsilon subdivisions,2WQ1C@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 CMS2_k127_4248943_16 1177928.TH2_17496 2.226e-10 66.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2JQUR@204441|Rhodospirillales 204441|Rhodospirillales T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg CMS2_k127_4248943_9 204669.Acid345_0750 3.539e-53 211.0 COG4191@1|root,COG4191@2|Bacteria,3Y5DB@57723|Acidobacteria,2JJS0@204432|Acidobacteriia 204432|Acidobacteriia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA CMS2_k127_4248943_2 1121918.ARWE01000001_gene445 4.065e-137 451.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains REC, sigma54 interaction, HTH8 - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_4248943_1 1267533.KB906735_gene4572 1.577e-142 460.0 COG0714@1|root,COG0714@2|Bacteria,3Y4G8@57723|Acidobacteria 57723|Acidobacteria S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS2_k127_4248943_4 1298867.AUES01000003_gene1132 3.171e-102 343.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,2TTXZ@28211|Alphaproteobacteria,3JVH9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 CMS2_k127_4248943_11 391612.CY0110_28199 1.914e-25 112.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - - - - - - - - - - BatA,CobT,DUF4381,VWA CMS2_k127_4248943_10 196490.AUEZ01000028_gene1941 2.647e-47 178.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2TUPX@28211|Alphaproteobacteria,3JV9D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S von Willebrand factor type A domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 CMS2_k127_4250544_6 1047013.AQSP01000142_gene230 3.964e-91 309.0 COG4030@1|root,COG4030@2|Bacteria 2|Bacteria M Protein of unknown function (DUF2961) - - - - - - - - - - - - DUF2961 CMS2_k127_4250544_4 1047013.AQSP01000133_gene2137 5.164e-107 365.0 COG1172@1|root,COG1172@2|Bacteria,2NPUE@2323|unclassified Bacteria 2|Bacteria U Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 CMS2_k127_4250544_2 1047013.AQSP01000133_gene2138 3.893e-151 496.0 COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria 2|Bacteria G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system rbsA - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - iLJ478.TM0956 ABC_tran CMS2_k127_4250544_15 335543.Sfum_0655 6.039e-28 121.0 COG4191@1|root,COG4191@2|Bacteria,1NC2K@1224|Proteobacteria,42WDG@68525|delta/epsilon subdivisions,2WRNM@28221|Deltaproteobacteria,2MS4V@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HisKA CMS2_k127_4250544_13 643562.Daes_0066 8.658e-34 142.0 COG0745@1|root,COG0745@2|Bacteria,1NE8H@1224|Proteobacteria,42NEH@68525|delta/epsilon subdivisions,2WK1M@28221|Deltaproteobacteria,2M7RK@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Cytidylate_kin2,Response_reg CMS2_k127_4250544_9 883.DvMF_1772 9.937e-46 177.0 COG2204@1|root,COG2204@2|Bacteria,1QUMA@1224|Proteobacteria,43BKZ@68525|delta/epsilon subdivisions,2X6Z5@28221|Deltaproteobacteria,2MH8W@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - Response_reg CMS2_k127_4250544_1 439235.Dalk_2933 6.074e-162 527.0 COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MHP3@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 CMS2_k127_4250544_14 1121440.AUMA01000002_gene2279 8.284e-33 131.0 COG2204@1|root,COG2204@2|Bacteria,1P58Q@1224|Proteobacteria,430GN@68525|delta/epsilon subdivisions,2WVMH@28221|Deltaproteobacteria,2MCHQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg CMS2_k127_4250544_12 96561.Dole_2331 1.383e-35 141.0 COG2204@1|root,COG2204@2|Bacteria,1RHEG@1224|Proteobacteria,42T1C@68525|delta/epsilon subdivisions,2WP30@28221|Deltaproteobacteria,2MK48@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg CMS2_k127_4250544_3 488538.SAR116_0190 5.199e-118 388.0 COG0730@1|root,COG0730@2|Bacteria,1Q2Z1@1224|Proteobacteria,2UJBP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE CMS2_k127_4250544_10 1121405.dsmv_0235 3.646e-41 163.0 COG1102@1|root,COG1102@2|Bacteria,1R1X4@1224|Proteobacteria,43DC5@68525|delta/epsilon subdivisions,2X8I5@28221|Deltaproteobacteria,2MPI3@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 CMS2_k127_4250544_7 84531.JMTZ01000003_gene2339 1.288e-83 287.0 COG0730@1|root,COG0730@2|Bacteria,1R6MR@1224|Proteobacteria,1S0QW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE CMS2_k127_4250544_8 697303.Thewi_2118 1.301e-65 238.0 COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24IZV@186801|Clostridia,42J2I@68295|Thermoanaerobacterales 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D CMS2_k127_4250544_0 1121904.ARBP01000026_gene694 1.373e-189 602.0 COG0673@1|root,COG0673@2|Bacteria,4NJ92@976|Bacteroidetes,47MAS@768503|Cytophagia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS2_k127_4250544_17 1440053.JOEI01000001_gene1686 6.713e-23 110.0 COG0524@1|root,COG0524@2|Bacteria,2GKQP@201174|Actinobacteria 201174|Actinobacteria G Carbohydrate kinase - - - - - - - - - - - - PfkB CMS2_k127_4250544_11 324057.Pjdr2_2540 5.305e-36 149.0 COG1082@1|root,COG1082@2|Bacteria 2|Bacteria G myo-inosose-2 dehydratase activity - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N CMS2_k127_4250544_5 65393.PCC7424_3595 7.589e-94 329.0 COG2866@1|root,COG2866@2|Bacteria,1G1CQ@1117|Cyanobacteria,3KGU0@43988|Cyanothece 1117|Cyanobacteria E PFAM peptidase M14 carboxypeptidase A - - - - - - - - - - - - Peptidase_M14 CMS2_k127_4250544_18 1410613.JNKF01000010_gene298 1.026e-09 59.0 COG3250@1|root,COG3250@2|Bacteria,4NESZ@976|Bacteroidetes,2FPDW@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N CMS2_k127_4256326_4 1047013.AQSP01000091_gene656 1.782e-40 172.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TPR_6 CMS2_k127_4256326_1 1047013.AQSP01000091_gene658 1.389e-85 289.0 COG0745@1|root,COG0745@2|Bacteria,2NPCK@2323|unclassified Bacteria 2|Bacteria T Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_4256326_0 1047013.AQSP01000091_gene657 1.351e-173 569.0 COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain rprX - 2.7.13.3 ko:K02484,ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_3,HAMP,HATPase_c,HisKA,Response_reg CMS2_k127_4256326_3 861299.J421_0278 8.231e-44 166.0 COG4636@1|root,COG4636@2|Bacteria,1ZUYJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative restriction endonuclease - - - - - - - - - - - - Uma2 CMS2_k127_4256326_2 234267.Acid_4321 1.634e-59 225.0 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - - - - - - - - - - - HATPase_c,HisKA CMS2_k127_425935_0 857087.Metme_2224 0.0 1304.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1XDIT@135618|Methylococcales 135618|Methylococcales G Glycosyl hydrolase 36 superfamily, catalytic domain - - - ko:K13688 - - - - ko00000,ko01000,ko01003 - GH94,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase CMS2_k127_425935_1 760192.Halhy_4898 1.356e-126 421.0 COG3250@1|root,COG3867@1|root,COG3250@2|Bacteria,COG3867@2|Bacteria,4NEWN@976|Bacteroidetes,1IRAX@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - BetaGal_dom4_5,DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N CMS2_k127_425935_2 926559.JoomaDRAFT_1349 9.309e-15 85.0 COG4783@1|root,COG4783@2|Bacteria,4NJ2X@976|Bacteroidetes,1I05N@117743|Flavobacteriia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2,TPR_8 CMS2_k127_4296766_19 1242864.D187_009365 3.247e-10 64.0 COG1404@1|root,COG2885@1|root,COG3291@1|root,COG1404@2|Bacteria,COG2885@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - 3.4.11.10 ko:K05994 - - - - ko00000,ko01000,ko01002 - - - PKD,Peptidase_S8 CMS2_k127_4296766_12 379066.GAU_0239 1.787e-86 305.0 2E0UX@1|root,32WC9@2|Bacteria,1ZUE1@142182|Gemmatimonadetes 2|Bacteria - - - - - - - - - - - - - - Phenol_MetA_deg CMS2_k127_4296766_13 1380390.JIAT01000014_gene6288 2.206e-30 141.0 COG0028@1|root,COG0515@1|root,COG1470@1|root,COG2133@1|root,COG3291@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1470@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - Calx-beta,DUF4347,GSDH,Laminin_G_3,PA14,PKD CMS2_k127_4296766_8 861299.J421_1666 7.368e-116 403.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_4296766_2 1047013.AQSP01000113_gene741 5.77e-211 672.0 COG1070@1|root,COG1070@2|Bacteria,2NQ9W@2323|unclassified Bacteria 2|Bacteria G FGGY family of carbohydrate kinases, N-terminal domain xylB - 1.1.1.57,2.7.1.17 ko:K00040,ko:K00854,ko:K19168 ko00040,ko01100,map00040,map01100 M00014,M00061 R01639,R02454 RC00002,RC00085,RC00538 ko00000,ko00001,ko00002,ko01000,ko02048 - - - FGGY_C,FGGY_N CMS2_k127_4296766_5 309799.DICTH_1588 9.591e-141 456.0 COG4952@1|root,COG4952@2|Bacteria 2|Bacteria M isomerase activity xylA_2 - 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - AP_endonuc_2 CMS2_k127_4296766_7 861299.J421_5990 1.443e-126 415.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_4296766_9 861299.J421_5991 3.9e-110 369.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_4296766_11 1379698.RBG1_1C00001G1666 3.562e-91 305.0 COG1136@1|root,COG1136@2|Bacteria,2NPA8@2323|unclassified Bacteria 2|Bacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_4296766_10 861299.J421_5993 1.513e-91 315.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS2_k127_4296766_1 706587.Desti_2026 5.466e-216 704.0 COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Spermine spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth CMS2_k127_4296766_17 1172186.KB911470_gene3084 2.262e-13 76.0 2EHX5@1|root,33BNR@2|Bacteria,2GPW7@201174|Actinobacteria,23ARP@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - CMS2_k127_4296766_4 861299.J421_2830 1.442e-142 479.0 COG1629@1|root,COG4771@2|Bacteria,1ZU8C@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - Plug CMS2_k127_4296766_14 861299.J421_2829 3.252e-28 130.0 2F5V8@1|root,33YE7@2|Bacteria,1ZUZ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4249) - - - - - - - - - - - - DUF4249 CMS2_k127_4296766_16 32057.KB217478_gene7144 3.463e-25 109.0 COG1695@1|root,COG1695@2|Bacteria,1GFIS@1117|Cyanobacteria 1117|Cyanobacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_4296766_6 1183438.GKIL_4354 4.858e-132 456.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_4296766_15 1278073.MYSTI_07739 6.847e-26 111.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria 1224|Proteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_4296766_3 234267.Acid_4580 8.07e-143 472.0 COG1680@1|root,COG1680@2|Bacteria 2|Bacteria V peptidase activity dap - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Beta-lactamase,DAP_B CMS2_k127_4296766_0 204669.Acid345_1918 0.0 1115.0 COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia 204432|Acidobacteriia C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase CMS2_k127_4296766_18 251221.35211983 6.67e-12 66.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_4310957_1 1047013.AQSP01000142_gene230 5.888e-166 532.0 COG4030@1|root,COG4030@2|Bacteria 2|Bacteria M Protein of unknown function (DUF2961) - - - - - - - - - - - - DUF2961 CMS2_k127_4310957_6 1499967.BAYZ01000173_gene5799 2.411e-126 411.0 COG1879@1|root,COG1879@2|Bacteria,2NQCX@2323|unclassified Bacteria 2|Bacteria G Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_4 CMS2_k127_4310957_0 706587.Desti_0626 2.739e-254 791.0 COG2407@1|root,COG2407@2|Bacteria,1NTJI@1224|Proteobacteria 1224|Proteobacteria G Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - - - - - - - - - - Fucose_iso_C CMS2_k127_4310957_14 518766.Rmar_0331 3.748e-83 290.0 COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,1FJUG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 CMS2_k127_4310957_13 517417.Cpar_0120 9.312e-88 311.0 COG1472@1|root,COG1472@2|Bacteria,1FDM0@1090|Chlorobi 1090|Chlorobi G PFAM glycoside hydrolase, family 3 domain protein - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C CMS2_k127_4310957_11 344747.PM8797T_04345 2.407e-92 317.0 COG1446@1|root,COG1446@2|Bacteria,2IZ4V@203682|Planctomycetes 203682|Planctomycetes E PFAM peptidase T2 asparaginase 2 - - 3.4.19.5,3.5.1.26 ko:K01444,ko:K13051 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000,ko01002 - - - Asparaginase_2,DUF4440 CMS2_k127_4310957_2 1235788.C802_00683 1.055e-162 524.0 COG0738@1|root,COG0738@2|Bacteria,4NEYR@976|Bacteroidetes,2FP5F@200643|Bacteroidia,4AMM2@815|Bacteroidaceae 976|Bacteroidetes G L-fucose H symporter permease fucP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 CMS2_k127_4310957_16 452637.Oter_3202 3.566e-42 158.0 COG1869@1|root,COG1869@2|Bacteria,46VR5@74201|Verrucomicrobia 74201|Verrucomicrobia G RbsD / FucU transport protein family - - 5.4.99.62 ko:K06726 ko02010,map02010 - R08247 RC02247 ko00000,ko00001,ko01000 - - - RbsD_FucU CMS2_k127_4310957_12 240015.ACP_3287 3.457e-91 306.0 COG1028@1|root,COG1028@2|Bacteria,3Y3G0@57723|Acidobacteria,2JHWU@204432|Acidobacteriia 204432|Acidobacteriia C dehydrogenase reductase - - - ko:K18333 ko00051,ko01120,map00051,map01120 - R08926 RC00066 ko00000,ko00001 - - - adh_short_C2 CMS2_k127_4310957_8 1089547.KB913013_gene4175 6.325e-100 340.0 COG3618@1|root,COG3618@2|Bacteria,4NFGB@976|Bacteroidetes,47JKH@768503|Cytophagia 976|Bacteroidetes S PFAM Amidohydrolase 2 - - - ko:K07046 ko00051,ko01120,map00051,map01120 - R10689 RC00537 ko00000,ko00001,ko01000 - - - Amidohydro_2 CMS2_k127_4310957_5 761193.Runsl_5334 3.82e-132 428.0 COG0179@1|root,COG0179@2|Bacteria,4NFMZ@976|Bacteroidetes,47N4F@768503|Cytophagia 976|Bacteroidetes Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - FAA_hydrolase CMS2_k127_4310957_9 1004149.AFOE01000050_gene2610 9.452e-98 329.0 COG1028@1|root,COG1028@2|Bacteria,4NH6Y@976|Bacteroidetes,1HXA4@117743|Flavobacteriia 976|Bacteroidetes IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 CMS2_k127_4310957_3 1121904.ARBP01000001_gene5448 3.075e-157 508.0 COG2755@1|root,COG3669@1|root,COG2755@2|Bacteria,COG3669@2|Bacteria,4NE74@976|Bacteroidetes,47KQM@768503|Cytophagia 976|Bacteroidetes G Alpha-L-fucosidase - - - - - - - - - - - - Alpha_L_fucos,Fucosidase_C CMS2_k127_4310957_10 435591.BDI_1657 3.865e-93 316.0 COG0524@1|root,COG0524@2|Bacteria,4NENQ@976|Bacteroidetes,2FPM3@200643|Bacteroidia,22XY8@171551|Porphyromonadaceae 976|Bacteroidetes H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB CMS2_k127_4310957_4 1121904.ARBP01000010_gene2296 9.83e-142 456.0 COG4975@1|root,COG4975@2|Bacteria,4NF22@976|Bacteroidetes,47JEJ@768503|Cytophagia 976|Bacteroidetes G Sugar transport protein glcU - - ko:K05340 - - - - ko00000,ko02000 2.A.7.5 - - Ureide_permease CMS2_k127_4310957_7 742726.HMPREF9448_02737 2.612e-119 402.0 COG1397@1|root,COG1397@2|Bacteria,4NG36@976|Bacteroidetes,2FNB7@200643|Bacteroidia,22X71@171551|Porphyromonadaceae 976|Bacteroidetes O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH CMS2_k127_4310957_15 1304275.C41B8_11298 1.089e-61 226.0 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,1RRR2@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the IUNH family - - - - - - - - - - - - IU_nuc_hydro CMS2_k127_4310957_17 1298880.AUEV01000010_gene2846 9.582e-27 111.0 COG4912@1|root,COG4912@2|Bacteria 2|Bacteria L Dna alkylation repair alkD - - - - - - - - - - - DNA_alkylation CMS2_k127_4342367_8 1317122.ATO12_14775 1.754e-18 91.0 arCOG10603@1|root,32SV6@2|Bacteria,4NZV7@976|Bacteroidetes,1IJ38@117743|Flavobacteriia,2YI5B@290174|Aquimarina 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_4342367_10 266117.Rxyl_2515 2.078e-07 56.0 COG3328@1|root,COG3328@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - Transposase_mut CMS2_k127_4342367_5 861299.J421_1545 6.187e-41 174.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS2_k127_4342367_6 1122963.AUHB01000011_gene1459 1.041e-35 138.0 COG5649@1|root,COG5649@2|Bacteria,1RGY3@1224|Proteobacteria,2U9AG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 CMS2_k127_4342367_0 1254432.SCE1572_02795 9.892e-116 392.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS2_k127_4342367_2 861299.J421_3294 1.682e-88 298.0 COG0377@1|root,COG0377@2|Bacteria,1ZT85@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 CMS2_k127_4342367_9 1163407.UU7_09270 6.885e-08 63.0 COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales 135614|Xanthomonadales S Putative adhesin - - - - - - - - - - - - DUF4097 CMS2_k127_4342367_3 861299.J421_6034 8.895e-52 211.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS2_k127_4342367_1 861299.J421_5836 1.654e-97 356.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_4342367_7 1123008.KB905693_gene1330 3.766e-26 115.0 COG4319@1|root,COG4319@2|Bacteria,4NT6G@976|Bacteroidetes,2FTV9@200643|Bacteroidia,22YRG@171551|Porphyromonadaceae 976|Bacteroidetes S Calcium/calmodulin dependent protein kinase II association domain - - - - - - - - - - - - DUF4440 CMS2_k127_4342367_4 1144275.COCOR_01591 2.05e-46 183.0 COG0457@1|root,COG2819@1|root,COG0457@2|Bacteria,COG2819@2|Bacteria,1R54Q@1224|Proteobacteria 1224|Proteobacteria S hydrolase of the alpha beta superfamily - - - ko:K07017 - - - - ko00000 - - - Esterase CMS2_k127_4369179_3 1237149.C900_05924 1.068e-27 118.0 COG0823@1|root,COG0823@2|Bacteria,4NIV7@976|Bacteroidetes,47RCS@768503|Cytophagia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_4369179_2 926561.KB900617_gene1952 3.387e-66 248.0 COG5373@1|root,COG5373@2|Bacteria,1UUGX@1239|Firmicutes,24EBQ@186801|Clostridia 186801|Clostridia S Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 CMS2_k127_4369179_0 880073.Calab_1003 3.644e-114 381.0 COG1301@1|root,COG1301@2|Bacteria,2NP6X@2323|unclassified Bacteria 2|Bacteria U Sodium:dicarboxylate symporter family gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF CMS2_k127_4369179_1 1266925.JHVX01000003_gene499 1.49e-92 327.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2WGWX@28216|Betaproteobacteria,37279@32003|Nitrosomonadales 28216|Betaproteobacteria T Cache domain - - - - - - - - - - - - GGDEF,HAMP,dCache_1 CMS2_k127_4388512_1 76114.ebA5622 4.226e-201 652.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales 206389|Rhodocyclales C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS2_k127_4388512_3 391625.PPSIR1_09331 7.269e-52 207.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria 2|Bacteria I 3-hydroxyacyl-CoA dehydrogenase paaH GO:0003674,GO:0003824,GO:0003857,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0008691,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - iECO103_1326.ECO103_1532,iJN746.PP_3282 3HCDH,3HCDH_N CMS2_k127_4388512_2 768066.HELO_3947 6.026e-69 248.0 COG0183@1|root,COG0183@2|Bacteria,1MXYM@1224|Proteobacteria,1S0V9@1236|Gammaproteobacteria,1XN9H@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N CMS2_k127_4388512_0 767817.Desgi_3972 5.77e-262 831.0 COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,264EG@186807|Peptococcaceae 186801|Clostridia C aldehyde oxidase and xanthine dehydrogenase a b hammerhead - - 1.17.1.4 ko:K00087 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 CMS2_k127_4389771_16 861299.J421_3181 2.083e-05 47.0 28Q1P@1|root,2ZB8E@2|Bacteria,1ZSPA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Zinc dependent phospholipase C - - - - - - - - - - - - Zn_dep_PLPC CMS2_k127_4389771_15 1379270.AUXF01000005_gene816 3.289e-09 63.0 2A100@1|root,30P5D@2|Bacteria,1ZUX1@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4389771_13 880073.Calab_1679 4.417e-17 88.0 COG0347@1|root,COG0347@2|Bacteria,2NRH8@2323|unclassified Bacteria 2|Bacteria K Belongs to the P(II) protein family - - - ko:K02806,ko:K04752 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - P-II CMS2_k127_4389771_2 492774.JQMB01000009_gene3213 4.421e-166 533.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,4BAZM@82115|Rhizobiaceae 28211|Alphaproteobacteria M EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase CMS2_k127_4389771_9 379066.GAU_1552 8.029e-39 156.0 COG1496@1|root,COG1496@2|Bacteria,1ZTTT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Multi-copper polyphenol oxidoreductase laccase - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 CMS2_k127_4389771_11 379066.GAU_1553 4.333e-19 94.0 COG0779@1|root,COG0779@2|Bacteria,1ZTX3@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C CMS2_k127_4389771_1 1379270.AUXF01000005_gene820 5.247e-190 603.0 COG0195@1|root,COG0195@2|Bacteria,1ZSNN@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N CMS2_k127_4389771_14 861299.J421_3187 5.518e-12 72.0 COG1358@1|root,COG1358@2|Bacteria,1ZU1M@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - - - - - - - - - - - - Ribosomal_L7Ae CMS2_k127_4389771_0 518766.Rmar_1309 2.883e-212 690.0 COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,1FIVX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N CMS2_k127_4389771_12 1379698.RBG1_1C00001G1154 4.062e-17 83.0 COG1550@1|root,COG1550@2|Bacteria,2NPYX@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF503) ylxP - - ko:K09764 - - - - ko00000 - - - DUF503 CMS2_k127_4389771_10 867903.ThesuDRAFT_00232 1.635e-24 106.0 COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,3WDII@538999|Clostridiales incertae sedis 186801|Clostridia J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA CMS2_k127_4389771_7 471852.Tcur_3327 1.411e-56 208.0 COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4EGVA@85012|Streptosporangiales 201174|Actinobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C,TruB_C_2,TruB_N CMS2_k127_4389771_4 861299.J421_3191 3.014e-92 314.0 COG0196@1|root,COG0196@2|Bacteria,1ZSM5@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Riboflavin kinase - - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase CMS2_k127_4389771_3 1379698.RBG1_1C00001G0345 5.122e-109 372.0 COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS2_k127_4389771_5 379066.GAU_1561 1.577e-85 301.0 COG0341@1|root,COG0341@2|Bacteria,1ZSSV@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS2_k127_4389771_6 596330.HMPREF0628_1289 7.729e-64 227.0 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,22G6R@1570339|Peptoniphilaceae 186801|Clostridia L hydrolase, TatD family tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase CMS2_k127_4389771_8 65672.G4TAR1 5.588e-41 155.0 COG0251@1|root,KOG2317@2759|Eukaryota,3A5RT@33154|Opisthokonta,3P5AT@4751|Fungi,3V1QC@5204|Basidiomycota,229S8@155619|Agaricomycetes,3H5N8@355688|Agaricomycetes incertae sedis 4751|Fungi J YjgF-like protein - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP CMS2_k127_438996_5 262724.TT_C1957 5.326e-39 159.0 COG1597@1|root,COG1597@2|Bacteria,1WI0N@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I PFAM Diacylglycerol kinase, catalytic bmrU - - - - - - - - - - - DAGK_cat CMS2_k127_438996_9 861299.J421_3196 2.251e-11 72.0 2FIMZ@1|root,34ADU@2|Bacteria,1ZTYV@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_438996_4 861299.J421_3198 1.71e-40 160.0 COG2908@1|root,COG2908@2|Bacteria,1ZTNP@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Calcineurin-like phosphoesterase - - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos CMS2_k127_438996_7 861299.J421_3199 8.168e-29 123.0 COG0824@1|root,COG0824@2|Bacteria,1ZTY3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT CMS2_k127_438996_2 309807.SRU_2431 4.394e-54 213.0 COG0652@1|root,COG1413@1|root,COG0652@2|Bacteria,COG1413@2|Bacteria,4PF1U@976|Bacteroidetes,1FK0E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes CO Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - HEAT_2,Pro_isomerase CMS2_k127_438996_10 379066.GAU_1568 0.0003849 51.0 2F5A9@1|root,33XWF@2|Bacteria,1ZTU9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_438996_6 861299.J421_3201 4.662e-38 148.0 2EPTK@1|root,33HE4@2|Bacteria,1ZTUK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lipopolysaccharide-assembly - - - - - - - - - - - - LptE CMS2_k127_438996_0 886293.Sinac_0383 4.363e-87 304.0 COG0475@1|root,COG0475@2|Bacteria,2IZ8F@203682|Planctomycetes 203682|Planctomycetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger CMS2_k127_438996_1 1379270.AUXF01000005_gene838 1.13e-83 284.0 COG0689@1|root,COG0689@2|Bacteria,1ZSYT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C CMS2_k127_438996_3 401526.TcarDRAFT_1170 3.853e-45 170.0 COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,4H4DD@909932|Negativicutes 909932|Negativicutes F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like CMS2_k127_438996_8 379066.GAU_2646 2.01e-13 70.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZSXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes EU Acetyl xylan esterase (AXE1) - - - - - - - - - - - - PD40,Peptidase_S9 CMS2_k127_4390376_18 1280390.CBQR020000146_gene3688 1.869e-76 264.0 COG0656@1|root,COG0656@2|Bacteria,1TSG5@1239|Firmicutes,4HAMT@91061|Bacilli,26QWW@186822|Paenibacillaceae 91061|Bacilli S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red CMS2_k127_4390376_3 1131812.JQMS01000001_gene412 4.76e-192 612.0 COG5520@1|root,COG5520@2|Bacteria,4NF4C@976|Bacteroidetes,1HZ2G@117743|Flavobacteriia,2NSZ6@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 30 family - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - Glyco_hydro_30,Glyco_hydro_30C CMS2_k127_4390376_15 1382359.JIAL01000001_gene998 7.554e-96 322.0 COG1402@1|root,COG1402@2|Bacteria,3Y3IW@57723|Acidobacteria,2JHT5@204432|Acidobacteriia 204432|Acidobacteriia S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS2_k127_4390376_1 1123508.JH636448_gene7659 1.963e-209 661.0 COG2730@1|root,COG2730@2|Bacteria,2IZBB@203682|Planctomycetes 203682|Planctomycetes G Protein of unknown function (DUF4038) - - - - - - - - - - - - Collagen_bind_2,DUF4038,DUF5060 CMS2_k127_4390376_7 880073.Calab_3094 3.075e-122 404.0 COG2730@1|root,COG2730@2|Bacteria,2NPWE@2323|unclassified Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_4_9,Cellulase CMS2_k127_4390376_8 485917.Phep_0681 5.515e-119 387.0 COG4821@1|root,COG4821@2|Bacteria,4NHQW@976|Bacteroidetes,1ITT0@117747|Sphingobacteriia 976|Bacteroidetes S SIS domain - - - - - - - - - - - - SIS_2 CMS2_k127_4390376_16 1236514.BAKL01000006_gene774 1.844e-84 294.0 COG0738@1|root,COG0738@2|Bacteria,4NHZ7@976|Bacteroidetes,2FPGQ@200643|Bacteroidia,4AMIG@815|Bacteroidaceae 976|Bacteroidetes G Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - MFS_1,Sugar_tr CMS2_k127_4390376_13 742727.HMPREF9447_04164 2.398e-97 328.0 COG1940@1|root,COG1940@2|Bacteria,4NHNJ@976|Bacteroidetes,2FQHI@200643|Bacteroidia,4AP2Z@815|Bacteroidaceae 976|Bacteroidetes GK Psort location Cytoplasmic, score - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK CMS2_k127_4390376_19 1408473.JHXO01000012_gene421 1.586e-75 261.0 COG2133@1|root,COG2133@2|Bacteria,4PMXZ@976|Bacteroidetes,2G0K9@200643|Bacteroidia 976|Bacteroidetes G Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 CMS2_k127_4390376_12 471854.Dfer_5616 2.058e-101 343.0 COG1735@1|root,COG1735@2|Bacteria,4NJYF@976|Bacteroidetes,47NZQ@768503|Cytophagia 976|Bacteroidetes S Phosphotriesterase family php - - ko:K07048 - - - - ko00000 - - - PTE CMS2_k127_4390376_9 880070.Cycma_3198 1.589e-114 379.0 COG1957@1|root,COG1957@2|Bacteria 2|Bacteria F ribosylpyrimidine nucleosidase activity - - - ko:K01250 - - - - ko00000,ko01000 - - - IU_nuc_hydro CMS2_k127_4390376_20 1500894.JQNN01000001_gene1392 4.74e-65 233.0 COG2273@1|root,COG2273@2|Bacteria,1NFHX@1224|Proteobacteria,2VS8Q@28216|Betaproteobacteria,477NM@75682|Oxalobacteraceae 28216|Betaproteobacteria G Glycosyl hydrolases family 16 - - - - - - - - - - - - Glyco_hydro_16 CMS2_k127_4390376_2 435591.BDI_2625 7.666e-199 635.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes 976|Bacteroidetes S Pfam Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA CMS2_k127_4390376_0 880070.Cycma_3594 7.949e-222 704.0 COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,4NEZJ@976|Bacteroidetes,47NF5@768503|Cytophagia 976|Bacteroidetes P Sulfatase - - - - - - - - - - - - HEAT_2,Sulfatase CMS2_k127_4390376_17 1382359.JIAL01000001_gene444 1.339e-78 275.0 COG2021@1|root,COG2021@2|Bacteria,3Y4JM@57723|Acidobacteria,2JJBE@204432|Acidobacteriia 204432|Acidobacteriia E alpha/beta hydrolase fold - - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 CMS2_k127_4390376_6 158189.SpiBuddy_0417 2.739e-136 441.0 COG0388@1|root,COG0388@2|Bacteria,2J9CB@203691|Spirochaetes 203691|Spirochaetes S Carbon-nitrogen hydrolase - - - - - - - - - - - - CN_hydrolase CMS2_k127_4390376_5 1122179.KB890491_gene4485 3.237e-157 509.0 COG0673@1|root,COG0673@2|Bacteria,4NF4Q@976|Bacteroidetes,1IQSY@117747|Sphingobacteriia 976|Bacteroidetes S Oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA CMS2_k127_4390376_10 886293.Sinac_7308 1.363e-107 360.0 COG1082@1|root,COG1082@2|Bacteria,2J0SX@203682|Planctomycetes 203682|Planctomycetes G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 CMS2_k127_4390376_24 161528.ED21_22118 3.181e-10 67.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,2TUU6@28211|Alphaproteobacteria,2K0I3@204457|Sphingomonadales 204457|Sphingomonadales QU Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,PD40 CMS2_k127_4390376_23 394503.Ccel_0798 7.539e-19 88.0 COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,36E56@31979|Clostridiaceae 186801|Clostridia Q amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 CMS2_k127_4390376_25 379066.GAU_1462 0.0001414 46.0 COG1629@1|root,COG1629@2|Bacteria 2|Bacteria P transport - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_4390376_21 1550091.JROE01000002_gene1131 1.025e-46 189.0 COG2312@1|root,COG2312@2|Bacteria,4NW00@976|Bacteroidetes,1ITY5@117747|Sphingobacteriia 976|Bacteroidetes S Erythromycin esterase - - - ko:K06880 - - - - ko00000,ko01000,ko01504 - - - CarbopepD_reg_2,Erythro_esteras CMS2_k127_4390376_11 309807.SRU_2346 2.876e-102 347.0 COG4826@1|root,COG4826@2|Bacteria,4NG1G@976|Bacteroidetes 976|Bacteroidetes O Belongs to the serpin family - - - ko:K13963 ko05146,map05146 - - - ko00000,ko00001 - - - Serpin CMS2_k127_4390376_14 861299.J421_5836 3.814e-97 327.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_4390376_4 452637.Oter_4336 4.257e-181 588.0 COG3534@1|root,COG3534@2|Bacteria,46UU3@74201|Verrucomicrobia 74201|Verrucomicrobia G Alpha-L-arabinofuranosidase C-terminus - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C CMS2_k127_4419994_11 933262.AXAM01000160_gene287 1.428e-12 73.0 COG4118@1|root,COG4118@2|Bacteria,1NPH8@1224|Proteobacteria 1224|Proteobacteria D Antitoxin Phd_YefM, type II toxin-antitoxin system - - - - - - - - - - - - PhdYeFM_antitox CMS2_k127_4419994_5 1541065.JRFE01000068_gene2703 8.12e-43 162.0 COG1487@1|root,COG1487@2|Bacteria,1G6K5@1117|Cyanobacteria 1117|Cyanobacteria S nucleic acid-binding protein contains PIN domain - - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN CMS2_k127_4419994_13 1121904.ARBP01000001_gene5465 1.597e-11 76.0 COG3595@1|root,COG3595@2|Bacteria,4NJCC@976|Bacteroidetes,47MIA@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - DUF4097 CMS2_k127_4419994_12 379066.GAU_0932 3.662e-12 76.0 2EVUZ@1|root,33P8Q@2|Bacteria,1ZTJQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4419994_6 945713.IALB_0468 5.018e-34 137.0 2BN55@1|root,33HC1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_4419994_7 309807.SRU_0176 5.092e-30 127.0 COG1595@1|root,COG1595@2|Bacteria,4NRYN@976|Bacteroidetes,1FK63@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_4419994_10 1124780.ANNU01000002_gene1499 6.545e-23 110.0 COG3712@1|root,COG3712@2|Bacteria,4NHZK@976|Bacteroidetes,47XJB@768503|Cytophagia 976|Bacteroidetes PT Domain of unknown function (DUF4974) - - - - - - - - - - - - DUF4974,FecR CMS2_k127_4419994_2 861299.J421_2386 1.216e-162 544.0 COG1629@1|root,COG4771@2|Bacteria,1ZU8C@142182|Gemmatimonadetes 2|Bacteria P Carboxypeptidase regulatory-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_4419994_1 56110.Oscil6304_1572 3.299e-166 542.0 COG2936@1|root,COG2936@2|Bacteria 2|Bacteria V dipeptidyl-peptidase activity - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 CMS2_k127_4419994_3 379066.GAU_2541 8.752e-106 357.0 COG0389@1|root,COG0389@2|Bacteria,1ZT65@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C CMS2_k127_4419994_8 765420.OSCT_0544 1.958e-24 116.0 COG0420@1|root,COG0420@2|Bacteria,2G60M@200795|Chloroflexi,3757S@32061|Chloroflexia 32061|Chloroflexia L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos CMS2_k127_4419994_14 670487.Ocepr_0559 1.324e-08 66.0 COG4733@1|root,COG4733@2|Bacteria,1WNI4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S cellulase activity - - - - - - - - - - - - - CMS2_k127_4419994_0 518766.Rmar_1178 1.962e-218 700.0 COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,1FJT8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase S46 dpp7 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_S46 CMS2_k127_4419994_9 1183438.GKIL_2903 5.398e-23 102.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_4419994_4 1278073.MYSTI_01766 2.429e-81 296.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria 1224|Proteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_4440004_0 1379270.AUXF01000001_gene2140 0.0 1322.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUC7@142182|Gemmatimonadetes 142182|Gemmatimonadetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 CMS2_k127_4440004_43 861299.J421_2919 7.325e-17 92.0 COG1629@1|root,COG1629@2|Bacteria,1ZTI4@142182|Gemmatimonadetes 2|Bacteria P Carboxypeptidase regulatory-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Caps_assemb_Wzi CMS2_k127_4440004_9 861299.J421_2967 4.035e-145 467.0 COG0462@1|root,COG0462@2|Bacteria,1ZT7Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N CMS2_k127_4440004_28 379066.GAU_1218 2.404e-49 184.0 COG1825@1|root,COG1825@2|Bacteria,1ZTHZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance - - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C CMS2_k127_4440004_29 379066.GAU_1217 1.438e-44 168.0 COG0193@1|root,COG0193@2|Bacteria,1ZTKT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro CMS2_k127_4440004_14 518766.Rmar_0027 6.382e-126 413.0 COG0012@1|root,COG0012@2|Bacteria,4NF7N@976|Bacteroidetes,1FJ4H@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C CMS2_k127_4440004_45 2325.TKV_c24610 2.141e-14 79.0 COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,42GUD@68295|Thermoanaerobacterales 186801|Clostridia J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 CMS2_k127_4440004_36 379066.GAU_1205 8.483e-27 111.0 COG0238@1|root,COG0238@2|Bacteria,1ZU47@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 CMS2_k127_4440004_46 861299.J421_2951 1.293e-09 70.0 2F1RZ@1|root,33US3@2|Bacteria,1ZUSC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - DUF2232 CMS2_k127_4440004_30 880073.Calab_2408 1.022e-42 161.0 COG0359@1|root,COG0359@2|Bacteria,2NPX4@2323|unclassified Bacteria 2|Bacteria J Binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N CMS2_k127_4440004_16 1121434.AULY01000006_gene568 3.893e-89 317.0 COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,42U2G@68525|delta/epsilon subdivisions,2WQBG@28221|Deltaproteobacteria,2M8TG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Dihydroxyacetone kinase family - - - ko:K07030 - - - - ko00000 - - - Dak2,DegV CMS2_k127_4440004_34 861299.J421_2949 7.589e-32 132.0 COG0799@1|root,COG0799@2|Bacteria,1ZU0S@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS CMS2_k127_4440004_41 379066.GAU_1196 8.722e-21 107.0 COG3087@1|root,COG3087@2|Bacteria,1ZSYS@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Sporulation related domain - - - - - - - - - - - - SPOR CMS2_k127_4440004_40 861299.J421_2946 3.518e-21 108.0 COG3087@1|root,COG3087@2|Bacteria,1ZTII@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Sporulation related domain - - - - - - - - - - - - SPOR CMS2_k127_4440004_2 861299.J421_2945 1.137e-274 884.0 COG1196@1|root,COG1196@2|Bacteria,1ZSY1@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge CMS2_k127_4440004_18 1379698.RBG1_1C00001G1263 1.896e-76 286.0 COG1404@1|root,COG1404@2|Bacteria,2NNSK@2323|unclassified Bacteria 2|Bacteria O Subtilase family aprN - - - - - - - - - - - Peptidase_S8 CMS2_k127_4440004_27 1379270.AUXF01000005_gene504 1.446e-50 205.0 2F30N@1|root,33VVY@2|Bacteria,1ZTT9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4440004_20 1379270.AUXF01000005_gene503 1.176e-69 244.0 COG1234@1|root,COG1234@2|Bacteria,1ZT5E@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 CMS2_k127_4440004_10 861299.J421_2942 1.998e-142 459.0 COG2876@1|root,COG2876@2|Bacteria,1ZTB0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 CMS2_k127_4440004_37 379066.GAU_1190 9.735e-27 117.0 COG2834@1|root,COG2834@2|Bacteria,1ZTXG@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Outer membrane lipoprotein carrier protein LolA - - - ko:K03634 - - - - ko00000 - - - LolA CMS2_k127_4440004_32 264732.Moth_0140 6.375e-37 152.0 COG5495@1|root,COG5495@2|Bacteria,1UZZU@1239|Firmicutes,249YF@186801|Clostridia,42G5H@68295|Thermoanaerobacterales 186801|Clostridia S NADP oxidoreductase coenzyme F420-dependent - - - - - - - - - - - - DUF2520,F420_oxidored,Rossmann-like CMS2_k127_4440004_13 861299.J421_2940 5.123e-133 446.0 COG0793@1|root,COG0793@2|Bacteria,1ZSUF@142182|Gemmatimonadetes 142182|Gemmatimonadetes M tail specific protease - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,Peptidase_S41 CMS2_k127_4440004_33 498761.HM1_0759 7.914e-34 139.0 COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia 186801|Clostridia F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin CMS2_k127_4440004_39 379066.GAU_1186 3.725e-22 99.0 COG3679@1|root,COG3679@2|Bacteria,1ZTRW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Control of competence regulator ComK, YlbF/YmcA - - - - - - - - - - - - Com_YlbF CMS2_k127_4440004_26 861299.J421_2937 3.207e-56 208.0 COG2890@1|root,COG2890@2|Bacteria,1ZTQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Methyltransferase small domain - - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS CMS2_k127_4440004_12 861299.J421_2936 4.122e-134 435.0 COG0216@1|root,COG0216@2|Bacteria,1ZSNT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 CMS2_k127_4440004_38 555079.Toce_2074 5.449e-26 112.0 COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,42H2T@68295|Thermoanaerobacterales 186801|Clostridia J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 CMS2_k127_4440004_21 861299.J421_2935 1.226e-63 229.0 COG0664@1|root,COG0664@2|Bacteria,1ZTHA@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, cAMP Regulatory protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding CMS2_k127_4440004_25 1120963.KB894491_gene1243 4.19e-58 213.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria,2Q2AM@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - - - - - - - - - - Lactamase_B_2 CMS2_k127_4440004_44 96561.Dole_0323 1.27e-16 89.0 COG5616@1|root,COG5616@2|Bacteria,1QW0Q@1224|Proteobacteria,43303@68525|delta/epsilon subdivisions,2WXN6@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG CMS2_k127_4440004_31 330214.NIDE1503 6.342e-42 164.0 COG0767@1|root,COG0767@2|Bacteria,3J0P4@40117|Nitrospirae 40117|Nitrospirae Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS2_k127_4440004_42 1123377.AUIV01000006_gene1536 1.604e-20 102.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1X3PT@135614|Xanthomonadales 135614|Xanthomonadales Q abc transporter atp-binding protein - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran CMS2_k127_4440004_47 1123058.KB894218_gene327 0.0007872 51.0 COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,1HXN5@117743|Flavobacteriia 976|Bacteroidetes Q ABC-type transport system involved in resistance to organic solvents periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS2_k127_4440004_7 204669.Acid345_4432 1.05e-157 520.0 COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,3Y61X@57723|Acidobacteria 57723|Acidobacteria T HD domain - - - - - - - - - - - - GAF,HD_5 CMS2_k127_4440004_5 42256.RradSPS_2485 1.054e-177 574.0 COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria 84995|Rubrobacteria EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B CMS2_k127_4440004_8 656024.FsymDg_0990 3.21e-149 495.0 COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria 201174|Actinobacteria EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B CMS2_k127_4440004_23 1379698.RBG1_1C00001G0380 7.759e-61 229.0 COG0815@1|root,COG0815@2|Bacteria,2NP0R@2323|unclassified Bacteria 2|Bacteria M Carbon-nitrogen hydrolase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase CMS2_k127_4440004_17 861299.J421_2930 2.265e-88 302.0 COG0673@1|root,COG0673@2|Bacteria,1ZSV9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Homoserine dehydrogenase, NAD binding domain - - - - - - - - - - - - GFO_IDH_MocA CMS2_k127_4440004_24 861299.J421_2928 8.163e-59 223.0 COG2385@1|root,COG2385@2|Bacteria,1ZT25@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID CMS2_k127_4440004_6 861299.J421_2927 1.407e-160 516.0 COG0621@1|root,COG0621@2|Bacteria,1ZT70@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,UPF0004 CMS2_k127_4440004_11 861299.J421_2922 8.881e-140 448.0 COG0568@1|root,COG0568@2|Bacteria,1ZSR6@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 CMS2_k127_4440004_4 379066.GAU_1166 5.137e-181 578.0 COG2204@1|root,COG2204@2|Bacteria,1ZT50@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_4440004_35 370438.PTH_0904 4.824e-31 130.0 COG1514@1|root,COG1514@2|Bacteria,1VEU2@1239|Firmicutes,24MTR@186801|Clostridia,262QN@186807|Peptococcaceae 186801|Clostridia J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase CMS2_k127_4440004_22 525904.Tter_1708 6.227e-63 228.0 COG1606@1|root,COG1606@2|Bacteria,2NP5T@2323|unclassified Bacteria 2|Bacteria L tRNA processing - - - ko:K06864 - - - - ko00000 - - - Asn_synthase,NAD_synthase CMS2_k127_4440004_15 404589.Anae109_0938 1.252e-92 312.0 COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YWME@29|Myxococcales 28221|Deltaproteobacteria L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku CMS2_k127_4440004_1 861299.J421_5987 1.527e-292 927.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria 2|Bacteria L DNA ligase (ATP) activity - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N CMS2_k127_4440004_19 1297865.APJD01000015_gene3469 4.429e-71 246.0 COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,3JSHJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S hydrolase of the alpha beta-hydrolase fold - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_6,DLH,Thioesterase CMS2_k127_4440004_3 309807.SRU_2034 6.913e-226 716.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1FJXZ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EU Prolyl oligopeptidase family - - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 CMS2_k127_4545911_0 264732.Moth_1755 2.009e-88 318.0 COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,42ESC@68295|Thermoanaerobacterales 186801|Clostridia P TIGRFAM potassium uptake protein, TrkH family ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH CMS2_k127_4545911_1 477974.Daud_1380 9.597e-43 175.0 COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,261KP@186807|Peptococcaceae 186801|Clostridia P PFAM TrkA-N domain ktrA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N CMS2_k127_4545911_3 1541065.JRFE01000014_gene1239 3.54e-23 112.0 COG5002@1|root,COG5002@2|Bacteria,1G4FM@1117|Cyanobacteria,3VMCU@52604|Pleurocapsales 1117|Cyanobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4 CMS2_k127_4545911_2 509191.AEDB02000019_gene4456 4.403e-27 118.0 2DUFI@1|root,33QET@2|Bacteria,1VTMU@1239|Firmicutes,24ZIK@186801|Clostridia,3WMZX@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - CMS2_k127_4570118_64 479434.Sthe_1585 4.531e-16 87.0 2EKS3@1|root,33EFV@2|Bacteria,2GBBM@200795|Chloroflexi,27YP9@189775|Thermomicrobia 189775|Thermomicrobia S Prokaryotic Cytochrome C oxidase subunit IV - - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - COX4_pro CMS2_k127_4570118_44 1379270.AUXF01000002_gene1827 2.859e-68 239.0 COG1845@1|root,COG1845@2|Bacteria,1ZT8Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c oxidase subunit III - - 1.9.3.1 ko:K02276,ko:K02299 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.5,3.D.4.6 - - COX3 CMS2_k127_4570118_0 1379270.AUXF01000002_gene1826 4.862e-253 793.0 COG0843@1|root,COG0843@2|Bacteria,1ZSMG@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 CMS2_k127_4570118_29 479434.Sthe_1582 3.673e-99 334.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2G6C0@200795|Chloroflexi,27XKX@189775|Thermomicrobia 189775|Thermomicrobia C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C CMS2_k127_4570118_54 1168034.FH5T_20155 4.457e-39 149.0 COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,2FY7P@200643|Bacteroidia 976|Bacteroidetes S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 CMS2_k127_4570118_39 644282.Deba_1084 4.112e-75 264.0 COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Ion transport 2 domain protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N CMS2_k127_4570118_57 1519464.HY22_10360 2.324e-35 139.0 COG0154@1|root,COG0154@2|Bacteria,1FDMC@1090|Chlorobi 2|Bacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase CMS2_k127_4570118_5 518766.Rmar_2008 2.596e-211 664.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FJ1P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 ko:K00128,ko:K00135 ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00027,M00135 R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS2_k127_4570118_68 502025.Hoch_3602 9.55e-10 70.0 2BBR2@1|root,32597@2|Bacteria,1QAQN@1224|Proteobacteria,43E36@68525|delta/epsilon subdivisions,2WZJR@28221|Deltaproteobacteria,2Z2A1@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4570118_46 886293.Sinac_6888 5.486e-63 226.0 COG0109@1|root,COG0109@2|Bacteria,2IYUU@203682|Planctomycetes 203682|Planctomycetes O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA CMS2_k127_4570118_73 1379270.AUXF01000001_gene2565 1.708e-05 52.0 2DWK2@1|root,340S5@2|Bacteria,1ZTSX@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4570118_33 933262.AXAM01000006_gene1881 1.641e-85 294.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2MI64@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS2_k127_4570118_58 1095769.CAHF01000009_gene1382 2.656e-34 137.0 COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,2VX3A@28216|Betaproteobacteria 28216|Betaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding CMS2_k127_4570118_12 404589.Anae109_2250 3.164e-149 494.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB-1 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate CMS2_k127_4570118_74 572544.Ilyop_0785 0.0001024 46.0 COG4887@1|root,COG4887@2|Bacteria,379B5@32066|Fusobacteria 32066|Fusobacteria S Protein of unknown function (DUF1847) - - - - - - - - - - - - DUF1847 CMS2_k127_4570118_72 926550.CLDAP_28510 1.271e-05 50.0 COG0731@1|root,COG0731@2|Bacteria,2G80U@200795|Chloroflexi 200795|Chloroflexi C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM CMS2_k127_4570118_59 1232410.KI421428_gene1021 8.123e-32 126.0 COG0011@1|root,COG0011@2|Bacteria,1N2GU@1224|Proteobacteria,42UPF@68525|delta/epsilon subdivisions,2WR94@28221|Deltaproteobacteria,43W2X@69541|Desulfuromonadales 28221|Deltaproteobacteria S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP CMS2_k127_4570118_40 1125863.JAFN01000001_gene248 6.704e-73 254.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS2_k127_4570118_20 977880.RALTA_A1536 4.454e-115 402.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth CMS2_k127_4570118_48 1340493.JNIF01000004_gene1025 5.982e-50 202.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - ko:K07004 - - - - ko00000 - - - PKD,PPC,Peptidase_M10,Peptidase_M28,SLH CMS2_k127_4570118_21 1379270.AUXF01000002_gene1163 1.665e-114 380.0 COG3342@1|root,COG3342@2|Bacteria 2|Bacteria S Family of unknown function (DUF1028) fimA - - - - - - - - - - - DUF1028,PG_binding_2 CMS2_k127_4570118_3 861299.J421_4071 3.238e-216 686.0 COG1574@1|root,COG1574@2|Bacteria,1ZTC9@142182|Gemmatimonadetes 2|Bacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 CMS2_k127_4570118_32 1340434.AXVA01000006_gene4317 4.1e-88 302.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4HBHX@91061|Bacilli,1ZDUD@1386|Bacillus 91061|Bacilli E Pyridoxal-phosphate dependent enzyme eutB - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_4570118_63 1162668.LFE_1863 3.122e-23 103.0 COG3536@1|root,COG3536@2|Bacteria,3J1AV@40117|Nitrospirae 40117|Nitrospirae S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 CMS2_k127_4570118_45 443218.AS9A_2937 3.42e-65 229.0 COG0819@1|root,COG0819@2|Bacteria,2IA0S@201174|Actinobacteria,235FM@1762|Mycobacteriaceae 201174|Actinobacteria K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway tenA - 3.5.99.2 ko:K03707 ko00730,ko01100,map00730,map01100 - R02133,R09993 RC00224,RC00652,RC02832 ko00000,ko00001,ko01000,ko03000 - - - TENA_THI-4 CMS2_k127_4570118_7 518766.Rmar_1178 4.446e-183 598.0 COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,1FJT8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase S46 dpp7 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_S46 CMS2_k127_4570118_61 1379270.AUXF01000001_gene2769 8.467e-27 121.0 2A1DQ@1|root,30PKX@2|Bacteria,1ZUYB@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4570118_56 1379270.AUXF01000001_gene2769 2.035e-36 147.0 2A1DQ@1|root,30PKX@2|Bacteria,1ZUYB@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4570118_18 861299.J421_0829 3.874e-122 407.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - GAF,HTH_8,Sigma54_activat CMS2_k127_4570118_70 103733.JNYO01000001_gene152 4.654e-08 64.0 COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4E27C@85010|Pseudonocardiales 201174|Actinobacteria T Tetratricopeptide repeat - - - - - - - - - - - - BTAD,NB-ARC,TPR_10,TPR_12,TPR_7,Trans_reg_C CMS2_k127_4570118_15 861299.J421_2170 7.671e-136 449.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_4570118_60 379066.GAU_1438 4.243e-28 127.0 2DWGD@1|root,3407S@2|Bacteria,1ZV24@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg CMS2_k127_4570118_27 861299.J421_3854 3.742e-104 352.0 COG0544@1|root,COG0544@2|Bacteria,1ZSSF@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig - - ko:K03545 - - - - ko00000 - - - Trigger_C,Trigger_N CMS2_k127_4570118_37 1442599.JAAN01000014_gene3643 7.816e-78 265.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1X3W7@135614|Xanthomonadales 135614|Xanthomonadales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease CMS2_k127_4570118_4 861299.J421_3856 9.5e-214 669.0 COG1219@1|root,COG1219@2|Bacteria,1ZT8F@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX CMS2_k127_4570118_52 1379270.AUXF01000003_gene3511 8.84e-41 158.0 COG0218@1|root,COG0218@2|Bacteria,1ZTHF@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 CMS2_k127_4570118_62 861299.J421_3859 3.264e-26 121.0 2F4EZ@1|root,33X55@2|Bacteria,1ZTSQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4570118_38 326427.Cagg_2013 1.072e-75 280.0 COG0745@1|root,COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg CMS2_k127_4570118_13 880073.Calab_3640 3.831e-148 496.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N CMS2_k127_4570118_28 861299.J421_3866 2.235e-100 353.0 2EWAK@1|root,33PPB@2|Bacteria,1ZT00@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4570118_14 330214.NIDE2040 1.185e-138 459.0 COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae 40117|Nitrospirae EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind CMS2_k127_4570118_19 861299.J421_3868 1.217e-117 398.0 COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1ZT7U@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - FHA,GAF,Guanylate_cyc CMS2_k127_4570118_47 379066.GAU_2420 2.605e-51 188.0 COG0424@1|root,COG0424@2|Bacteria,1ZTP7@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf CMS2_k127_4570118_51 1400520.LFAB_08495 9.273e-42 158.0 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,3F6GK@33958|Lactobacillaceae 91061|Bacilli J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase CMS2_k127_4570118_10 379066.GAU_2428 1.92e-158 514.0 COG1109@1|root,COG1109@2|Bacteria,1ZSNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS2_k127_4570118_9 861299.J421_3896 4.253e-162 521.0 COG0626@1|root,COG0626@2|Bacteria,1ZT9F@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.1 ko:K01758 ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230 M00338 R00782,R01001,R02408,R04770,R04930,R09366 RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP CMS2_k127_4570118_26 861299.J421_3897 1.071e-104 350.0 COG0501@1|root,COG0501@2|Bacteria,1ZT2E@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 CMS2_k127_4570118_25 627192.SLG_02320 2.026e-107 362.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,2K0GD@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N CMS2_k127_4570118_53 882.DVU_3256 4.097e-39 156.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,42R8W@68525|delta/epsilon subdivisions,2WMZU@28221|Deltaproteobacteria,2M8M3@213115|Desulfovibrionales 28221|Deltaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS CMS2_k127_4570118_41 1192034.CAP_4860 1.399e-72 261.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2YXMW@29|Myxococcales 28221|Deltaproteobacteria L GIY-YIG type nucleases (URI domain) - - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - UVR CMS2_k127_4570118_42 83406.HDN1F_24210 1.441e-69 249.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1J5UZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex CMS2_k127_4570118_43 379066.GAU_2441 2.891e-69 245.0 COG0500@1|root,COG2226@2|Bacteria,1ZSNE@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran CMS2_k127_4570118_34 1379270.AUXF01000003_gene3484 5.343e-82 277.0 COG1595@1|root,COG1595@2|Bacteria,1ZT3B@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_4570118_24 1379270.AUXF01000003_gene3479 4.46e-109 364.0 COG0489@1|root,COG0489@2|Bacteria,1ZSW7@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA CMS2_k127_4570118_30 861299.J421_3916 1.864e-95 323.0 COG0618@1|root,COG0618@2|Bacteria,1ZSS0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DHH family - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 CMS2_k127_4570118_23 555079.Toce_1451 3.925e-113 381.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,42FA0@68295|Thermoanaerobacterales 186801|Clostridia E amino acid carrier protein agcS - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp CMS2_k127_4570118_1 379066.GAU_2451 6.926e-236 739.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1ZTG9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH CMS2_k127_4570118_69 861299.J421_3920 2.301e-08 61.0 2F9BP@1|root,341NP@2|Bacteria,1ZTX1@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4570118_75 1473546.CH76_02870 0.0001156 54.0 COG0860@1|root,COG3807@1|root,COG0860@2|Bacteria,COG3807@2|Bacteria,1UYPW@1239|Firmicutes,4HBVT@91061|Bacilli,3IWAC@400634|Lysinibacillus 91061|Bacilli MT N-acetylmuramoyl-L-alanine amidase lytH GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,SH3_3 CMS2_k127_4570118_67 1379270.AUXF01000003_gene3466 1.683e-12 76.0 2F8UF@1|root,3416F@2|Bacteria,1ZTX9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4570118_55 485918.Cpin_6957 1.711e-38 148.0 COG0720@1|root,COG0720@2|Bacteria,4NNY0@976|Bacteroidetes,1ISCG@117747|Sphingobacteriia 976|Bacteroidetes H 6-pyruvoyl tetrahydrobiopterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS CMS2_k127_4570118_50 861299.J421_5587 5.168e-47 176.0 COG0746@1|root,COG0746@2|Bacteria,1ZU64@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 CMS2_k127_4570118_22 861299.J421_3927 6.501e-114 382.0 COG0303@1|root,COG0303@2|Bacteria,1ZT4D@142182|Gemmatimonadetes 142182|Gemmatimonadetes H MoeA N-terminal region (domain I and II) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N CMS2_k127_4570118_31 1198452.Jab_2c22520 1.872e-94 314.0 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,2VHS8@28216|Betaproteobacteria,472JN@75682|Oxalobacteraceae 28216|Betaproteobacteria M Asp/Glu/Hydantoin racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race CMS2_k127_4570118_11 1117318.PRUB_17817 4.218e-158 516.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,2PZXJ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria C Malic enzyme maeA GO:0003674,GO:0003824,GO:0004470,GO:0004471,GO:0004473,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006094,GO:0006108,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019318,GO:0019319,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0055114,GO:0071704,GO:1901576 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E1742 Malic_M,malic CMS2_k127_4570118_17 555079.Toce_1828 1.247e-126 415.0 COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia,42EP7@68295|Thermoanaerobacterales 186801|Clostridia C PFAM Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit gcdB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta CMS2_k127_4570118_16 573413.Spirs_4017 1.266e-133 447.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J5JF@203691|Spirochaetes 203691|Spirochaetes C Oxaloacetate decarboxylase, alpha subunit oadA - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA CMS2_k127_4570118_65 1343739.PAP_03780 2.693e-14 83.0 COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,243TN@183968|Thermococci 183968|Thermococci H Biotin protein ligase C terminal domain - - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB CMS2_k127_4570118_49 1319815.HMPREF0202_01058 1.234e-47 190.0 COG0591@1|root,COG0591@2|Bacteria,379A5@32066|Fusobacteria 32066|Fusobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS2_k127_4570118_2 1379698.RBG1_1C00001G0629 1.763e-225 711.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor etf GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 CMS2_k127_4570118_35 1191523.MROS_2811 9.56e-80 277.0 COG2025@1|root,COG2025@2|Bacteria 2|Bacteria C fatty acid beta-oxidation using acyl-CoA dehydrogenase etfA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha CMS2_k127_4570118_36 1379270.AUXF01000003_gene3456 5.76e-78 268.0 COG2086@1|root,COG2086@2|Bacteria,1ZT51@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Electron transfer flavoprotein domain - - - ko:K03521 - - - - ko00000 - - - ETF CMS2_k127_4570118_66 1461693.ATO10_06121 2.741e-13 71.0 COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,1N10V@1224|Proteobacteria 1224|Proteobacteria S Divergent 4Fe-4S mono-cluster yjdI - - - - - - - - - - - Fer4_19,zf-CDGSH CMS2_k127_4570118_8 1232410.KI421426_gene1373 1.776e-175 567.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,43U78@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP CMS2_k127_4570118_6 1123371.ATXH01000010_gene751 1.244e-199 642.0 COG0272@1|root,COG0272@2|Bacteria,2GGUH@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 CMS2_k127_4570257_4 1156919.QWC_08636 2.721e-193 625.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,3T379@506|Alcaligenaceae 28216|Betaproteobacteria S Penicillin penA - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase CMS2_k127_4570257_1 251221.35211322 0.0 1114.0 COG2866@1|root,COG2866@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS2_k127_4570257_17 693661.Arcve_1013 1.68e-55 204.0 COG0388@1|root,arCOG00062@2157|Archaea,2Y5JI@28890|Euryarchaeota 28890|Euryarchaeota S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase CMS2_k127_4570257_8 648996.Theam_0181 3.795e-138 451.0 COG0498@1|root,COG0498@2|Bacteria,2G3NU@200783|Aquificae 200783|Aquificae E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC_2 - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_4570257_5 1047013.AQSP01000089_gene1175 7.233e-166 529.0 COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria 2|Bacteria E Cys/Met metabolism PLP-dependent enzyme metC - 2.5.1.48,4.4.1.11,4.4.1.8 ko:K01739,ko:K01760,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP CMS2_k127_4570257_11 379066.GAU_1064 2.208e-97 331.0 2E1RX@1|root,32X1X@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_4570257_16 316067.Geob_3013 7.675e-61 220.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,43THN@69541|Desulfuromonadales 28221|Deltaproteobacteria S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo CMS2_k127_4570257_14 1049564.TevJSym_aq00670 1.043e-75 261.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1J4WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr CMS2_k127_4570257_15 1049564.TevJSym_aq00680 1.345e-74 256.0 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1JBVX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfE2 - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr CMS2_k127_4570257_19 1049564.TevJSym_aq00690 1.314e-34 143.0 COG4659@1|root,COG4659@2|Bacteria,1REZV@1224|Proteobacteria,1T054@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport - - - - - - - - - - - - FMN_bind CMS2_k127_4570257_10 1049564.TevJSym_aq00700 1.424e-103 346.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1J55P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE CMS2_k127_4570257_7 765910.MARPU_10730 1.631e-138 453.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WXET@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_8,RnfC_N,SLBB CMS2_k127_4570257_0 1379270.AUXF01000001_gene2161 0.0 1947.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C CMS2_k127_4570257_13 1249627.D779_4188 2.447e-93 314.0 COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria,1WWC5@135613|Chromatiales 135613|Chromatiales C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 CMS2_k127_4570257_12 1049564.TevJSym_bb00040 2.209e-97 328.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C CMS2_k127_4570257_3 1049564.TevJSym_bb00050 2.381e-230 732.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N CMS2_k127_4570257_9 926549.KI421517_gene3367 2.283e-119 398.0 COG0520@1|root,COG0520@2|Bacteria,4NF4G@976|Bacteroidetes,47M48@768503|Cytophagia 976|Bacteroidetes E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS2_k127_4570257_20 861299.J421_6031 7.636e-29 121.0 COG0517@1|root,COG0517@2|Bacteria,1ZV6T@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS CMS2_k127_4570257_18 316274.Haur_3795 3.172e-50 189.0 COG1528@1|root,COG1528@2|Bacteria,2G8JG@200795|Chloroflexi,37728@32061|Chloroflexia 32061|Chloroflexia C Iron-storage protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin CMS2_k127_4570257_6 309807.SRU_0080 2.013e-154 507.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,4NDWV@976|Bacteroidetes,1FJJA@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Phosphoglucose isomerase tal - 2.2.1.2,5.3.1.9 ko:K00616,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000 - - - PGI,TAL_FSA CMS2_k127_4570257_2 861299.J421_4436 2.043e-231 748.0 COG2866@1|root,COG2866@2|Bacteria,1ZSMP@142182|Gemmatimonadetes 2|Bacteria E Zinc carboxypeptidase - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS2_k127_459442_11 861299.J421_1760 0.0001553 53.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_459442_4 1144275.COCOR_00260 9.63e-137 467.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria 1224|Proteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_459442_9 861299.J421_0257 1.283e-12 73.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_459442_8 391623.TERMP_02055 4.579e-15 87.0 COG1672@1|root,arCOG03169@2157|Archaea,2Y6A2@28890|Euryarchaeota,243U6@183968|Thermococci 183968|Thermococci S ATPase, AAA superfamily - - - - - - - - - - - - ATPase_2 CMS2_k127_459442_0 234267.Acid_4578 2.953e-228 732.0 COG0577@1|root,COG0577@2|Bacteria,3Y36E@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_459442_3 1047013.AQSP01000091_gene657 1.416e-149 498.0 COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain rprX - 2.7.13.3 ko:K02484,ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_3,HAMP,HATPase_c,HisKA,Response_reg CMS2_k127_459442_6 1047013.AQSP01000091_gene658 8.939e-88 295.0 COG0745@1|root,COG0745@2|Bacteria,2NPCK@2323|unclassified Bacteria 2|Bacteria T Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_459442_5 1047013.AQSP01000091_gene656 3.161e-120 413.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TPR_6 CMS2_k127_459442_2 251221.35211765 8.277e-154 516.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_459442_10 1396418.BATQ01000130_gene4890 1.242e-05 49.0 2DBR4@1|root,2ZAI1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Laminin_G_3 CMS2_k127_459442_1 251221.35211765 5.427e-187 617.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_459442_7 861299.J421_1545 2.418e-21 108.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS2_k127_4596759_17 313596.RB2501_11632 1.123e-05 56.0 COG2834@1|root,COG2834@2|Bacteria,4NHV3@976|Bacteroidetes,1I15K@117743|Flavobacteriia 976|Bacteroidetes M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - DUF4292,LolA_like CMS2_k127_4596759_2 861299.J421_2387 7.007e-81 282.0 COG1680@1|root,COG1680@2|Bacteria,1ZV34@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_4596759_18 1121904.ARBP01000005_gene4644 1.948e-05 55.0 2BSYX@1|root,32N2S@2|Bacteria,4PJX3@976|Bacteroidetes,47PX2@768503|Cytophagia 976|Bacteroidetes S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl_2 CMS2_k127_4596759_0 861299.J421_2386 1.163e-153 514.0 COG1629@1|root,COG4771@2|Bacteria,1ZU8C@142182|Gemmatimonadetes 2|Bacteria P Carboxypeptidase regulatory-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_4596759_16 68260.JOAY01000002_gene5159 8.603e-08 63.0 COG3595@1|root,COG3595@2|Bacteria,2GKT3@201174|Actinobacteria 201174|Actinobacteria S domain, Protein - - - - - - - - - - - - DUF4097 CMS2_k127_4596759_15 706436.HMPREF9074_07891 3.247e-17 97.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,1HXF4@117743|Flavobacteriia,1EQ7U@1016|Capnocytophaga 976|Bacteroidetes M TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_4596759_11 861299.J421_0442 2.737e-27 120.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_4596759_12 861299.J421_2829 5.52e-24 117.0 2F5V8@1|root,33YE7@2|Bacteria,1ZUZ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4249) - - - - - - - - - - - - DUF4249 CMS2_k127_4596759_1 861299.J421_2830 1.2e-139 475.0 COG1629@1|root,COG4771@2|Bacteria,1ZU8C@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - Plug CMS2_k127_4596759_14 160488.PP_0866 3.245e-20 102.0 COG3712@1|root,COG3712@2|Bacteria,1MZCK@1224|Proteobacteria,1S9Q3@1236|Gammaproteobacteria,1YW7U@136845|Pseudomonas putida group 1236|Gammaproteobacteria PT Anti-FecI sigma factor, FecR - - - ko:K07165 - - - - ko00000 - - - DUF4880,DUF4974,FecR CMS2_k127_4596759_13 518766.Rmar_2618 2.112e-23 108.0 COG1595@1|root,COG1595@2|Bacteria,4NNBY@976|Bacteroidetes 976|Bacteroidetes K RNA polymerase sigma-70 factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_4596759_8 660470.Theba_2456 1.215e-41 167.0 COG1262@1|root,COG1262@2|Bacteria,2GEAZ@200918|Thermotogae 200918|Thermotogae O PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - FGE-sulfatase,PDZ_2 CMS2_k127_4596759_4 518766.Rmar_1860 1.393e-71 258.0 COG3279@1|root,COG3279@2|Bacteria,4NEAH@976|Bacteroidetes,1FJ14@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg CMS2_k127_4596759_3 1254432.SCE1572_26545 2.759e-78 274.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria,2Z0T8@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase CMS2_k127_4596759_7 251221.35212369 2.017e-49 198.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid MA20_39390 - 3.5.2.6 ko:K17837 ko01501,map01501 - R06363 RC01499 ko00000,ko00001,ko01000 - - - Lactamase_B CMS2_k127_4596759_10 1036674.A28LD_1916 5.05e-38 156.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria,2QG05@267893|Idiomarinaceae 1236|Gammaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B CMS2_k127_4596759_5 1122604.JONR01000010_gene3922 2.402e-59 212.0 29KMP@1|root,307IZ@2|Bacteria,1REJ6@1224|Proteobacteria,1S7K0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4287) - - - - - - - - - - - - DUF4287 CMS2_k127_4596759_6 997346.HMPREF9374_2141 2.203e-50 181.0 COG0346@1|root,COG0346@2|Bacteria,1V4S3@1239|Firmicutes,4HIIR@91061|Bacilli,27CGM@186824|Thermoactinomycetaceae 91061|Bacilli E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase CMS2_k127_4596759_9 643648.Slip_1333 1.485e-38 158.0 COG2020@1|root,COG2020@2|Bacteria,1V0PB@1239|Firmicutes,24AQ6@186801|Clostridia 186801|Clostridia O Isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - ICMT,PEMT CMS2_k127_4627804_7 861299.J421_3418 1.603e-192 605.0 COG4799@1|root,COG4799@2|Bacteria,1ZTGE@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Carboxyl transferase domain - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans CMS2_k127_4627804_13 861299.J421_3417 3.001e-166 537.0 COG0439@1|root,COG0439@2|Bacteria,1ZTBD@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS2_k127_4627804_49 379066.GAU_1781 1.526e-66 243.0 COG2265@1|root,COG2265@2|Bacteria,1ZSPC@142182|Gemmatimonadetes 142182|Gemmatimonadetes H tRNA (Uracil-5-)-methyltransferase - - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr CMS2_k127_4627804_72 861299.J421_3415 4.672e-28 119.0 COG4770@1|root,COG4770@2|Bacteria,1ZTVQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin-requiring enzyme - - - - - - - - - - - - Biotin_lipoyl CMS2_k127_4627804_16 880073.Calab_3241 1.441e-154 505.0 COG0439@1|root,COG0439@2|Bacteria,2NNWM@2323|unclassified Bacteria 2|Bacteria I acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS2_k127_4627804_3 502025.Hoch_5456 1.526e-251 787.0 COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM carboxyl transferase gcdA - 4.1.1.70 ko:K01615 ko00362,ko00650,ko01120,map00362,map00650,map01120 - R03028 RC00832 ko00000,ko00001,ko01000,ko02000 3.B.1.1.3 - - Carboxyl_trans CMS2_k127_4627804_76 502025.Hoch_5457 1.196e-21 103.0 COG0511@1|root,COG0511@2|Bacteria 2|Bacteria I ligase activity, forming carbon-carbon bonds accB - 2.3.1.12,2.3.1.39,4.1.1.3 ko:K00627,ko:K00645,ko:K01572,ko:K02160 ko00010,ko00020,ko00061,ko00333,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00333,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00307,M00376 R00209,R00217,R00742,R01626,R02569,R11671 RC00004,RC00039,RC00040,RC00367,RC02727,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko01004,ko02000 3.B.1.1.1 - - Acyl_transf_1,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 CMS2_k127_4627804_37 309807.SRU_1659 1.24e-88 307.0 COG3174@1|root,COG3174@2|Bacteria,4NKP6@976|Bacteroidetes,1FJWC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC CMS2_k127_4627804_55 1379270.AUXF01000006_gene117 3.922e-57 203.0 COG0102@1|root,COG0102@2|Bacteria,1ZTIS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 CMS2_k127_4627804_60 861299.J421_3413 3.831e-53 190.0 COG0103@1|root,COG0103@2|Bacteria,1ZTM0@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S9/S16 rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 CMS2_k127_4627804_32 1379270.AUXF01000006_gene119 7.192e-100 334.0 COG0052@1|root,COG0052@2|Bacteria,1ZSNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S2 rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 CMS2_k127_4627804_48 941449.dsx2_1695 3.09e-67 234.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria,2M9B7@213115|Desulfovibrionales 28221|Deltaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS CMS2_k127_4627804_35 1379270.AUXF01000006_gene121 5.405e-98 327.0 COG0528@1|root,COG0528@2|Bacteria,1ZSY2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase CMS2_k127_4627804_61 861299.J421_3409 8.138e-53 196.0 COG0233@1|root,COG0233@2|Bacteria,1ZTI2@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF CMS2_k127_4627804_62 379066.GAU_1771 1.744e-50 190.0 COG4589@1|root,COG4589@2|Bacteria,1ZTGH@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Cytidylyltransferase family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 CMS2_k127_4627804_17 861299.J421_3406 1.574e-145 470.0 COG0743@1|root,COG0743@2|Bacteria,1ZTFR@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom CMS2_k127_4627804_47 1123368.AUIS01000001_gene2043 4.268e-68 248.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,2NC9P@225057|Acidithiobacillales 225057|Acidithiobacillales M Peptidase family M50 - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Peptidase_M50 CMS2_k127_4627804_44 1379270.AUXF01000006_gene128 6.438e-73 258.0 COG0515@1|root,COG0515@2|Bacteria,1ZTE2@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_4627804_69 1379270.AUXF01000006_gene129 2.017e-32 128.0 COG0184@1|root,COG0184@2|Bacteria,1ZU0C@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 CMS2_k127_4627804_1 379066.GAU_1764 3.817e-276 866.0 COG1185@1|root,COG1185@2|Bacteria,1ZT7C@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 CMS2_k127_4627804_19 1379270.AUXF01000006_gene131 2.611e-135 444.0 COG0612@1|root,COG0612@2|Bacteria,1ZSPT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_4627804_11 861299.J421_3399 5.002e-173 549.0 COG0686@1|root,COG0686@2|Bacteria,1ZSSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Alanine dehydrogenase/PNT, N-terminal domain - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N CMS2_k127_4627804_8 861299.J421_3398 4.176e-184 579.0 COG1077@1|root,COG1077@2|Bacteria,1ZT9B@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Hsp70 protein - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl CMS2_k127_4627804_63 1379270.AUXF01000006_gene134 4.492e-46 177.0 COG1792@1|root,COG1792@2|Bacteria,1ZSYE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M rod shape-determining protein MreC - - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC CMS2_k127_4627804_68 861299.J421_3396 8.455e-33 133.0 2CIX2@1|root,33ZZP@2|Bacteria,1ZTZK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S rod shape-determining protein MreD - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD CMS2_k127_4627804_10 379066.GAU_1758 5.937e-179 579.0 COG0768@1|root,COG0768@2|Bacteria,1ZSX5@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Penicillin-binding Protein dimerisation domain - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase CMS2_k127_4627804_21 379066.GAU_1757 1.02e-126 417.0 COG0772@1|root,COG0772@2|Bacteria,1ZSXM@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell cycle protein - - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE CMS2_k127_4627804_28 861299.J421_3393 3.903e-107 354.0 COG0777@1|root,COG0777@2|Bacteria,1ZSSK@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans CMS2_k127_4627804_40 379066.GAU_1755 2.949e-82 288.0 COG0285@1|root,COG0285@2|Bacteria,1ZSRP@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Mur ligase middle domain - - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M CMS2_k127_4627804_20 861299.J421_3391 3.622e-131 431.0 COG0124@1|root,COG0124@2|Bacteria,1ZSXX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_His CMS2_k127_4627804_4 861299.J421_3390 7.571e-210 662.0 COG0442@1|root,COG0442@2|Bacteria,1ZT48@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b CMS2_k127_4627804_26 502025.Hoch_5513 3.102e-109 367.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2YUK3@29|Myxococcales 28221|Deltaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC CMS2_k127_4627804_46 861299.J421_3386 1.394e-68 236.0 COG1762@1|root,COG1762@2|Bacteria,1ZTIY@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 CMS2_k127_4627804_22 379066.GAU_1740 1.878e-124 407.0 COG0042@1|root,COG0042@2|Bacteria,1ZSQC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - - - - - - - - - - Dus CMS2_k127_4627804_45 338966.Ppro_0625 9.602e-71 249.0 COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,43U0V@69541|Desulfuromonadales 28221|Deltaproteobacteria S AIR carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC CMS2_k127_4627804_71 1346791.M529_21065 1.536e-30 138.0 COG2199@1|root,COG3850@1|root,COG2199@2|Bacteria,COG3850@2|Bacteria,1QTZT@1224|Proteobacteria,2U16Y@28211|Alphaproteobacteria,2KCJI@204457|Sphingomonadales 204457|Sphingomonadales T Diguanylate cyclase - - - - - - - - - - - - GGDEF,HAMP CMS2_k127_4627804_0 324602.Caur_2963 0.0 1081.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi,376J5@32061|Chloroflexia 32061|Chloroflexia H Belongs to the PEP-utilizing enzyme family - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N CMS2_k127_4627804_12 861299.J421_3381 1.539e-166 536.0 COG0034@1|root,COG0034@2|Bacteria,1ZTD7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6 CMS2_k127_4627804_57 379066.GAU_1734 2.537e-56 207.0 COG1183@1|root,COG1183@2|Bacteria,1ZTJP@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf CMS2_k127_4627804_50 861299.J421_3375 4.058e-66 236.0 COG0688@1|root,COG0688@2|Bacteria,1ZU9Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase CMS2_k127_4627804_24 258594.RPA0558 9.734e-115 378.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TS0T@28211|Alphaproteobacteria,3JRJ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F phosphoribosylaminoimidazole-succinocarboxamide synthase purC2 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt CMS2_k127_4627804_15 379066.GAU_1731 2.529e-158 518.0 COG0015@1|root,COG0015@2|Bacteria,1ZSVW@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Adenylosuccinate lyase C-terminus - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 CMS2_k127_4627804_25 379066.GAU_1730 3.026e-112 382.0 COG0265@1|root,COG0265@2|Bacteria,1ZTAM@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS2_k127_4627804_39 903818.KI912268_gene2680 1.948e-82 281.0 COG0176@1|root,COG0176@2|Bacteria,3Y4BN@57723|Acidobacteria 57723|Acidobacteria G Transaldolase/Fructose-6-phosphate aldolase - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA CMS2_k127_4627804_51 1379270.AUXF01000006_gene161 2.887e-65 236.0 COG0101@1|root,COG0101@2|Bacteria,1ZSRZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 CMS2_k127_4627804_34 861299.J421_3367 2.176e-98 338.0 COG0547@1|root,COG0547@2|Bacteria,1ZTDS@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 CMS2_k127_4627804_41 379066.GAU_1726 1.793e-80 272.0 COG1974@1|root,COG1974@2|Bacteria,1ZSSM@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 CMS2_k127_4627804_58 1122609.AUGT01000012_gene4354 1.699e-54 206.0 COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4DNTB@85009|Propionibacteriales 201174|Actinobacteria E Indole-3-glycerol phosphate synthase trpC GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS CMS2_k127_4627804_9 861299.J421_3363 6.665e-182 577.0 COG0133@1|root,COG0133@2|Bacteria,1ZSUM@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_4627804_30 379066.GAU_1722 1.081e-101 352.0 COG1413@1|root,COG1413@2|Bacteria,1ZUI4@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS2_k127_4627804_18 379066.GAU_1721 1.891e-136 450.0 COG2206@1|root,COG2206@2|Bacteria,1ZUTT@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD CMS2_k127_4627804_53 926550.CLDAP_27220 2.716e-63 227.0 COG0159@1|root,COG0159@2|Bacteria,2G6AY@200795|Chloroflexi 200795|Chloroflexi E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA CMS2_k127_4627804_75 243231.GSU0935 5.23e-24 119.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42P4R@68525|delta/epsilon subdivisions,2WUG1@28221|Deltaproteobacteria 28221|Deltaproteobacteria NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal CMS2_k127_4627804_74 861299.J421_3361 1.264e-26 114.0 COG1539@1|root,COG1539@2|Bacteria 2|Bacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB2 - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB CMS2_k127_4627804_70 1410626.JHXB01000005_gene1362 7.71e-31 126.0 COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,27TH3@186928|unclassified Lachnospiraceae 186801|Clostridia H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK CMS2_k127_4627804_38 880073.Calab_1733 1.632e-84 290.0 COG0413@1|root,COG0413@2|Bacteria,2NP1G@2323|unclassified Bacteria 2|Bacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf CMS2_k127_4627804_42 697303.Thewi_0541 1.659e-79 276.0 COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,42F66@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase CMS2_k127_4627804_67 1379270.AUXF01000006_gene171 3.639e-34 139.0 COG1713@1|root,COG1713@2|Bacteria,1ZTTH@142182|Gemmatimonadetes 142182|Gemmatimonadetes H HD superfamily hydrolase involved in NAD metabolism - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - - CMS2_k127_4627804_27 861299.J421_3358 1.282e-107 359.0 COG0820@1|root,COG0820@2|Bacteria,1ZTAJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM CMS2_k127_4627804_5 379066.GAU_1715 2.097e-199 637.0 COG0173@1|root,COG0173@2|Bacteria,1ZTFX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon CMS2_k127_4627804_23 1379270.AUXF01000006_gene175 1.091e-116 388.0 COG1702@1|root,COG1702@2|Bacteria,1ZSSD@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PhoH-like protein - - - ko:K06217 - - - - ko00000 - - - PhoH CMS2_k127_4627804_14 861299.J421_3354 1.393e-159 529.0 COG1480@1|root,COG1480@2|Bacteria 2|Bacteria O 7TM receptor with intracellular HD hydrolase yqfF - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD CMS2_k127_4627804_73 861299.J421_3353 1.394e-27 118.0 COG0319@1|root,COG0319@2|Bacteria,1ZTUP@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 CMS2_k127_4627804_43 861299.J421_3352 5.328e-77 272.0 COG1253@1|root,COG1253@2|Bacteria,1ZT3E@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC CMS2_k127_4627804_66 290397.Adeh_3839 1.944e-36 154.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42QX1@68525|delta/epsilon subdivisions,2WMNH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S CBS domain containing protein corC - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC,DUF21 CMS2_k127_4627804_65 795666.MW7_2280 2.548e-39 156.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,1JZZY@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 CMS2_k127_4627804_31 1150600.ADIARSV_1185 3.259e-100 342.0 COG2239@1|root,COG2239@2|Bacteria,4NGGN@976|Bacteroidetes,1IPNC@117747|Sphingobacteriia 976|Bacteroidetes P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N CMS2_k127_4627804_29 861299.J421_3350 4.76e-106 355.0 COG1703@1|root,COG1703@2|Bacteria,1ZT8J@142182|Gemmatimonadetes 142182|Gemmatimonadetes E ArgK protein - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK CMS2_k127_4627804_2 861299.J421_3349 5.741e-258 804.0 COG1884@1|root,COG1884@2|Bacteria,1ZUKS@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Methylmalonyl-CoA mutase - - 5.4.99.13,5.4.99.2 ko:K01848,ko:K11942 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase CMS2_k127_4627804_59 224324.aq_199 2.099e-53 205.0 COG1503@1|root,COG1503@2|Bacteria 2|Bacteria J translation release factor activity yocB GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - - CMS2_k127_4627804_52 1379270.AUXF01000006_gene183 7.509e-65 224.0 COG2185@1|root,COG2185@2|Bacteria,1ZTNN@142182|Gemmatimonadetes 142182|Gemmatimonadetes I B12 binding domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding CMS2_k127_4627804_36 1519464.HY22_01960 2.862e-96 351.0 COG1404@1|root,COG1404@2|Bacteria,1FEZ9@1090|Chlorobi 1090|Chlorobi O Subtilase family - - - - - - - - - - - - Peptidase_S8 CMS2_k127_4627804_6 861299.J421_3345 3.714e-195 623.0 COG3185@1|root,COG3185@2|Bacteria,1ZT5D@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA CMS2_k127_4627804_64 861299.J421_3344 2.122e-43 164.0 2CIU6@1|root,32S8H@2|Bacteria,1ZTUM@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4627804_56 1313301.AUGC01000015_gene1856 1.83e-56 206.0 COG1024@1|root,COG1024@2|Bacteria,4NI32@976|Bacteroidetes 976|Bacteroidetes I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS2_k127_4627804_79 1197477.IA57_07885 7.54e-05 52.0 2CBC0@1|root,3301N@2|Bacteria,4NUWS@976|Bacteroidetes,1I66E@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_4627804_33 1499967.BAYZ01000009_gene5378 7.791e-99 332.0 COG1234@1|root,COG1234@2|Bacteria 2|Bacteria L tRNA 3'-trailer cleavage - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 CMS2_k127_4627804_54 1121405.dsmv_0026 2.011e-59 209.0 COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2MJZR@213118|Desulfobacterales 28221|Deltaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT CMS2_k127_4627804_78 693979.Bache_0370 4.094e-07 57.0 COG5652@1|root,COG5652@2|Bacteria,4NXUQ@976|Bacteroidetes,2FSFT@200643|Bacteroidia,4AQVD@815|Bacteroidaceae 976|Bacteroidetes S Psort location CytoplasmicMembrane, score 9.46 fjo27 - - - - - - - - - - - VanZ CMS2_k127_4627804_77 880073.Calab_3039 2.099e-20 103.0 COG1670@1|root,COG1670@2|Bacteria,2NRQI@2323|unclassified Bacteria 2|Bacteria J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 CMS2_k127_463429_1 861299.J421_1219 4.084e-247 799.0 COG4206@1|root,COG4206@2|Bacteria,1ZTBA@142182|Gemmatimonadetes 142182|Gemmatimonadetes H CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_463429_0 1047013.AQSP01000113_gene740 0.0 1181.0 COG1472@1|root,COG1472@2|Bacteria,2NNR4@2323|unclassified Bacteria 2|Bacteria G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 CMS2_k127_463429_5 1278073.MYSTI_02643 4.622e-150 489.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,42STW@68525|delta/epsilon subdivisions,2WPBB@28221|Deltaproteobacteria,2YUQE@29|Myxococcales 28221|Deltaproteobacteria E Peptidase dimerisation domain - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS2_k127_463429_2 861299.J421_5624 1.325e-221 705.0 COG4948@1|root,COG4948@2|Bacteria 2|Bacteria M carboxylic acid catabolic process - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - GH97_C,GH97_N,Glyco_hydro_97 CMS2_k127_463429_15 926569.ANT_28370 1.682e-30 131.0 COG1651@1|root,COG1651@2|Bacteria,2G769@200795|Chloroflexi 200795|Chloroflexi O PFAM DSBA oxidoreductase - - - - - - - - - - - - Thioredoxin_4 CMS2_k127_463429_7 886293.Sinac_0672 1.39e-111 371.0 COG0451@1|root,COG0451@2|Bacteria,2IXGI@203682|Planctomycetes 203682|Planctomycetes GM NAD dependent epimerase/dehydratase family - - - - - - - - - - - - Epimerase CMS2_k127_463429_6 886293.Sinac_0671 2.43e-129 424.0 COG0329@1|root,COG0329@2|Bacteria,2IXEF@203682|Planctomycetes 203682|Planctomycetes EM Belongs to the DapA family - - - - - - - - - - - - DHDPS CMS2_k127_463429_4 518766.Rmar_2108 2.856e-162 531.0 COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,1FIXA@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS2_k127_463429_19 376733.IT41_15705 1.077e-19 96.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,2PY62@265|Paracoccus 28211|Alphaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - MerB,Pyr_redox_2,Pyr_redox_dim CMS2_k127_463429_17 479434.Sthe_2507 2.568e-23 106.0 COG0346@1|root,COG0622@1|root,COG0346@2|Bacteria,COG0622@2|Bacteria,2G8MU@200795|Chloroflexi 200795|Chloroflexi C PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - DinB_2 CMS2_k127_463429_9 102129.Lepto7375DRAFT_8055 3.33e-95 317.0 28XBK@1|root,2ZJ9G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_463429_13 28444.JODQ01000006_gene21 1.141e-32 136.0 COG0546@1|root,COG0546@2|Bacteria,2GJRT@201174|Actinobacteria,4EHMA@85012|Streptosporangiales 201174|Actinobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2,Hydrolase CMS2_k127_463429_21 1117379.BABA_10676 5.752e-11 71.0 2950P@1|root,2ZYQG@2|Bacteria,1V5HG@1239|Firmicutes,4HI30@91061|Bacilli,1ZKTA@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - CMS2_k127_463429_14 1123229.AUBC01000030_gene1396 7.937e-32 131.0 28P6Z@1|root,2ZC1H@2|Bacteria,1NZU8@1224|Proteobacteria,2UUUK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function with HXXEE motif - - - - - - - - - - - - HXXEE CMS2_k127_463429_22 861299.J421_0602 1.364e-06 57.0 28RT4@1|root,2ZE5G@2|Bacteria,1ZV80@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_463429_20 373994.Riv7116_3043 4.437e-12 76.0 2AR31@1|root,31GC4@2|Bacteria,1GJZT@1117|Cyanobacteria,1HSZ8@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS2_k127_463429_8 1333998.M2A_1586 2.935e-100 344.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,4BS41@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V Beta-lactamase MA20_17095 - - - - - - - - - - - Beta-lactamase CMS2_k127_463429_10 521045.Kole_1066 1.845e-75 263.0 COG4221@1|root,COG4221@2|Bacteria 2|Bacteria IQ oxidoreductase activity acr1 - - - - - - - - - - - NAD_binding_4,adh_short CMS2_k127_463429_11 324925.Ppha_2031 3.374e-45 166.0 COG3093@1|root,COG3093@2|Bacteria 2|Bacteria K addiction module antidote protein HigA - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3,HTH_31 CMS2_k127_463429_12 497965.Cyan7822_2340 3.174e-37 142.0 COG3549@1|root,COG3549@2|Bacteria,1GB1B@1117|Cyanobacteria 1117|Cyanobacteria S Plasmid maintenance system killer - - - ko:K07334 - - - - ko00000,ko02048 - - - HigB-like_toxin CMS2_k127_463429_18 324925.Ppha_1441 5.413e-22 106.0 COG1598@1|root,COG1598@2|Bacteria 2|Bacteria N PFAM Uncharacterised protein family UPF0150 - - - - - - - - - - - - HicB_lk_antitox CMS2_k127_463429_16 1541065.JRFE01000009_gene4505 7.515e-27 110.0 COG1724@1|root,COG1724@2|Bacteria,1G9BE@1117|Cyanobacteria,3VKJT@52604|Pleurocapsales 1117|Cyanobacteria N HicA toxin of bacterial toxin-antitoxin, - - - - - - - - - - - - HicA_toxin CMS2_k127_463429_3 861299.J421_6371 3.929e-168 561.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6371|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_463696_24 102125.Xen7305DRAFT_00044400 6.228e-05 55.0 COG0265@1|root,COG0265@2|Bacteria,1G17C@1117|Cyanobacteria,3VHQ5@52604|Pleurocapsales 1117|Cyanobacteria O PDZ domain (Also known as DHR or GLGF) hhoA GO:0003674,GO:0005488,GO:0005515,GO:0042802 - - - - - - - - - - PDZ_2,Trypsin_2 CMS2_k127_463696_16 861299.J421_1666 9.297e-62 235.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_463696_22 309800.C498_02810 1.092e-14 83.0 arCOG04198@1|root,arCOG04198@2157|Archaea,2XU58@28890|Euryarchaeota,23UGH@183963|Halobacteria 183963|Halobacteria Q TIGRFAM DMSO reductase family type II enzyme, heme b subunit - - - ko:K17052 - - - - ko00000,ko02000 5.A.3.8 - - EB_dh CMS2_k127_463696_6 653733.Selin_0567 6.028e-121 412.0 COG0348@1|root,COG1622@1|root,COG0348@2|Bacteria,COG1622@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor vnfA - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1,Fer4_5,Sigma54_activat,cNMP_binding CMS2_k127_463696_23 653733.Selin_0566 1.639e-14 78.0 COG4633@1|root,COG4633@2|Bacteria 2|Bacteria - - silP - 1.9.3.1,3.6.3.54 ko:K02275,ko:K17686 ko00190,ko01100,ko01524,ko04016,map00190,map01100,map01524,map04016 M00155 R00081,R00086 RC00002,RC00016 ko00000,ko00001,ko00002,ko01000 3.A.3.5,3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1,DsbD_2,HMA CMS2_k127_463696_8 1379270.AUXF01000001_gene2741 1.798e-102 342.0 COG3342@1|root,COG3342@2|Bacteria,1ZUQB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028 CMS2_k127_463696_1 861299.J421_0768 3.262e-168 542.0 COG2234@1|root,COG2234@2|Bacteria,1ZT6Z@142182|Gemmatimonadetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS2_k127_463696_12 644282.Deba_2856 3.425e-78 286.0 COG2202@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase fleS - 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg CMS2_k127_463696_21 706587.Desti_5336 1.085e-26 114.0 COG0745@1|root,COG0745@2|Bacteria,1NBQZ@1224|Proteobacteria,42V8P@68525|delta/epsilon subdivisions,2WS87@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg CMS2_k127_463696_7 886377.Murru_2529 1.209e-104 352.0 COG1680@1|root,COG1680@2|Bacteria,4NTSG@976|Bacteroidetes,1IIMJ@117743|Flavobacteriia 976|Bacteroidetes V Fibrobacter succinogenes major domain (Fib_succ_major) - - - - - - - - - - - - Beta-lactamase,Fib_succ_major CMS2_k127_463696_0 1123278.KB893623_gene3429 1.196e-189 605.0 COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes,47NMR@768503|Cytophagia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_463696_15 1120968.AUBX01000011_gene3102 1.682e-69 259.0 COG2866@1|root,COG2866@2|Bacteria,4NH4I@976|Bacteroidetes,47MEA@768503|Cytophagia 976|Bacteroidetes E Zn_pept - - - - - - - - - - - - Peptidase_M14 CMS2_k127_463696_17 1128421.JAGA01000002_gene557 8.743e-58 226.0 COG2866@1|root,COG2866@2|Bacteria,2NPI7@2323|unclassified Bacteria 2|Bacteria E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Peptidase_M14 CMS2_k127_463696_4 1047013.AQSP01000115_gene352 6.84e-125 415.0 COG0454@1|root,COG0456@2|Bacteria,2NNUP@2323|unclassified Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - - CMS2_k127_463696_5 861299.J421_5836 8.688e-122 419.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_463696_9 335543.Sfum_2526 1.169e-83 288.0 COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria,42ZF3@68525|delta/epsilon subdivisions,2WUZY@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TGS domain - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS CMS2_k127_463696_19 765913.ThidrDRAFT_0326 2.071e-39 164.0 COG1073@1|root,COG1073@2|Bacteria,1MY4C@1224|Proteobacteria,1RNS3@1236|Gammaproteobacteria,1WY2Y@135613|Chromatiales 135613|Chromatiales S Alpha beta - - - - - - - - - - - - Hydrolase_4 CMS2_k127_463696_2 861299.J421_2386 1.588e-149 503.0 COG1629@1|root,COG4771@2|Bacteria,1ZU8C@142182|Gemmatimonadetes 2|Bacteria P Carboxypeptidase regulatory-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_463696_11 945713.IALB_2742 1.376e-78 287.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity ptp - - - - - - - - - - - Peptidase_S37 CMS2_k127_463696_3 935863.AWZR01000005_gene2169 1.761e-130 428.0 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,1RQA1@1236|Gammaproteobacteria,1XC3M@135614|Xanthomonadales 135614|Xanthomonadales S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS2_k127_463696_14 861299.J421_1887 1.866e-72 253.0 COG3382@1|root,COG3382@2|Bacteria 2|Bacteria J B3 4 domain protein - - - - - - - - - - - - B3_4 CMS2_k127_463696_13 1125863.JAFN01000001_gene1103 2.897e-73 249.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RIQ@68525|delta/epsilon subdivisions,2WNC7@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM PEBP family protein - - - ko:K06910 - - - - ko00000 - - - PBP CMS2_k127_463696_10 1255043.TVNIR_3060 7.835e-79 273.0 COG1352@1|root,COG1352@2|Bacteria,1RDBE@1224|Proteobacteria,1SJIV@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT Methyltransferase, chemotaxis proteins - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR CMS2_k127_463696_20 1125863.JAFN01000001_gene1900 5.717e-28 119.0 COG1708@1|root,COG1708@2|Bacteria 2|Bacteria S nucleotidyltransferase activity - - - ko:K17882 - - - - ko00000,ko01000,ko01504 - - - NTP_transf_2 CMS2_k127_463696_18 383372.Rcas_3227 8.72e-54 193.0 COG2250@1|root,COG2250@2|Bacteria,2G6UN@200795|Chloroflexi 200795|Chloroflexi S Hepn domain protein - - - - - - - - - - - - HEPN CMS2_k127_4651405_3 861299.J421_6342 6.029e-14 77.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_4651405_1 485913.Krac_5098 1.863e-19 92.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_4651405_0 1144275.COCOR_00260 2.52e-147 499.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria 1224|Proteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_4651405_2 211110.gbs1990 3.938e-14 76.0 COG1695@1|root,COG1695@2|Bacteria,1VANP@1239|Firmicutes,4HM54@91061|Bacilli 91061|Bacilli K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_4665715_2 648757.Rvan_0035 5.135e-110 361.0 COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.21 ko:K07539 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05593,R05594,R10696 RC01430,RC01431,RC03237 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS2_k127_4665715_3 316067.Geob_0099 1.5e-91 307.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS2_k127_4665715_0 706587.Desti_2452 8.02e-129 422.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS2_k127_4665715_5 706587.Desti_2451 7.891e-25 109.0 COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria,2MRW8@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc CMS2_k127_4665715_4 1125863.JAFN01000001_gene2446 3.074e-44 171.0 COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,42NZQ@68525|delta/epsilon subdivisions,2WMCW@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.100 ko:K07537 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05597 RC03168 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 CMS2_k127_4665715_1 1379698.RBG1_1C00001G0894 4.241e-114 372.0 COG1775@1|root,COG1775@2|Bacteria,2NRF8@2323|unclassified Bacteria 2|Bacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D CMS2_k127_4679647_13 861299.J421_4349 5.824e-32 133.0 COG3346@1|root,COG3346@2|Bacteria,1ZTTS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SURF1 family - - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 CMS2_k127_4679647_9 861299.J421_1404 1.095e-72 253.0 COG0120@1|root,COG0120@2|Bacteria 2|Bacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 ko:K00851,ko:K00852,ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01051,R01056,R01737,R02750 RC00002,RC00017,RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A CMS2_k127_4679647_0 644966.Tmar_1686 0.0 1150.0 COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia 186801|Clostridia C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C CMS2_k127_4679647_8 105559.Nwat_1689 3.094e-83 294.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1WYC3@135613|Chromatiales 135613|Chromatiales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin CMS2_k127_4679647_12 379066.GAU_2528 3.23e-32 130.0 COG1186@1|root,COG1186@2|Bacteria,1ZTZD@142182|Gemmatimonadetes 142182|Gemmatimonadetes J RF-1 domain - - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 CMS2_k127_4679647_6 485918.Cpin_1363 1.753e-108 370.0 COG2303@1|root,COG2303@2|Bacteria,4NEF2@976|Bacteroidetes,1IXR8@117747|Sphingobacteriia 976|Bacteroidetes E GMC oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 CMS2_k127_4679647_14 1194165.CAJF01000006_gene2434 6.864e-28 128.0 COG0673@1|root,COG0673@2|Bacteria,2IEY3@201174|Actinobacteria,4FQUY@85023|Microbacteriaceae 201174|Actinobacteria S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS2_k127_4679647_3 56110.Oscil6304_5436 2.908e-162 525.0 COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria,1H8G7@1150|Oscillatoriales 1117|Cyanobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB CMS2_k127_4679647_11 1173028.ANKO01000006_gene2075 2.951e-32 129.0 COG3288@1|root,COG3288@2|Bacteria,1G711@1117|Cyanobacteria,1HBSJ@1150|Oscillatoriales 1117|Cyanobacteria C NAD NADP transhydrogenase alpha subunit pntA-2 - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM CMS2_k127_4679647_5 118168.MC7420_5104 7.405e-123 404.0 COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1H7A5@1150|Oscillatoriales 1117|Cyanobacteria C NAD NADP transhydrogenase alpha subunit pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM CMS2_k127_4679647_4 330214.NIDE1574 8.049e-125 410.0 COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_14,Mob_synth_C,Radical_SAM CMS2_k127_4679647_1 1121904.ARBP01000003_gene6496 1.657e-279 885.0 COG0308@1|root,COG0308@2|Bacteria,4NGTZ@976|Bacteroidetes,47MWS@768503|Cytophagia 976|Bacteroidetes E Peptidase family M1 domain pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 CMS2_k127_4679647_10 1499967.BAYZ01000039_gene2214 3.378e-68 245.0 2CEJC@1|root,32R1S@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_4679647_2 1499967.BAYZ01000039_gene2211 3.455e-169 545.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein pqqE GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM CMS2_k127_4679647_7 1499967.BAYZ01000039_gene2210 3.071e-94 322.0 COG1512@1|root,COG1512@2|Bacteria 2|Bacteria S TPM domain - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase CMS2_k127_4703663_3 313595.P700755_000875 4.879e-27 118.0 2AXAT@1|root,31P9W@2|Bacteria,4PKR4@976|Bacteroidetes,1IJCX@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DUF4303 CMS2_k127_4703663_1 1123508.JH636440_gene2368 9.306e-46 176.0 COG0823@1|root,COG0823@2|Bacteria,2IZKS@203682|Planctomycetes 203682|Planctomycetes U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS2_k127_4703663_0 1297742.A176_07575 9.73e-106 351.0 COG4034@1|root,COG4034@2|Bacteria,1RCEU@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF1152) - - - - - - - - - - - - DUF1152 CMS2_k127_4703663_6 356851.JOAN01000023_gene4885 2.199e-06 53.0 2BB1V@1|root,324HY@2|Bacteria,2H9E5@201174|Actinobacteria,4DJWG@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - CMS2_k127_4703663_5 290397.Adeh_2872 5.611e-18 88.0 2FCAT@1|root,344EF@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_4703663_2 497965.Cyan7822_2340 5.938e-38 144.0 COG3549@1|root,COG3549@2|Bacteria,1GB1B@1117|Cyanobacteria 1117|Cyanobacteria S Plasmid maintenance system killer - - - ko:K07334 - - - - ko00000,ko02048 - - - HigB-like_toxin CMS2_k127_4703663_4 324925.Ppha_2031 1.326e-26 109.0 COG3093@1|root,COG3093@2|Bacteria 2|Bacteria K addiction module antidote protein HigA - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3,HTH_31 CMS2_k127_4727822_2 861299.J421_1864 1.428e-92 327.0 COG0038@1|root,COG0038@2|Bacteria 2|Bacteria P chloride channel clcA - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC CMS2_k127_4727822_3 517418.Ctha_0981 4.947e-65 244.0 COG4206@1|root,COG4206@2|Bacteria,1FE55@1090|Chlorobi 1090|Chlorobi M TonB-dependent receptor plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec CMS2_k127_4727822_0 1047013.AQSP01000108_gene2058 9.746e-201 657.0 COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_4727822_6 981223.AIED01000041_gene115 0.0004093 49.0 2EJRP@1|root,33DGF@2|Bacteria,1NJMC@1224|Proteobacteria,1SJF1@1236|Gammaproteobacteria,3NPDT@468|Moraxellaceae 1236|Gammaproteobacteria S Uncharacterised protein family UPF0547 - - - - - - - - - - - - UPF0547 CMS2_k127_4727822_1 426117.M446_6968 4.86e-130 435.0 COG4626@1|root,COG4626@2|Bacteria,1MW9D@1224|Proteobacteria,2TVMI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Terminase - - - - - - - - - - - - - CMS2_k127_4727822_5 324057.Pjdr2_0502 1.45e-14 75.0 COG1476@1|root,COG1476@2|Bacteria,1VEKB@1239|Firmicutes,4IQ1D@91061|Bacilli,2765W@186822|Paenibacillaceae 91061|Bacilli K Helix-turn-helix XRE-family like proteins - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 CMS2_k127_4727822_4 272134.KB731326_gene335 3.889e-19 88.0 COG3666@1|root,COG3666@2|Bacteria,1GEUC@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 CMS2_k127_4728883_11 344747.PM8797T_15706 2.545e-47 175.0 COG3119@1|root,COG3119@2|Bacteria,2IXMP@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - DUF4976,Sulfatase CMS2_k127_4728883_14 643867.Ftrac_1336 4.917e-36 148.0 2E10Y@1|root,32WGY@2|Bacteria,4NTDG@976|Bacteroidetes,47UNZ@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_4728883_12 1123020.AUIE01000022_gene3075 7.51e-40 160.0 COG0671@1|root,COG0671@2|Bacteria,1PSMC@1224|Proteobacteria,1TBR5@1236|Gammaproteobacteria,1YIMT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Acid phosphatase homologues - - - - - - - - - - - - PAP2 CMS2_k127_4728883_4 1379698.RBG1_1C00001G0607 7.891e-150 500.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 CMS2_k127_4728883_15 582402.Hbal_0558 5.71e-23 106.0 COG4319@1|root,COG4319@2|Bacteria,1PZUG@1224|Proteobacteria,2V19B@28211|Alphaproteobacteria,44001@69657|Hyphomonadaceae 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS2_k127_4728883_9 653733.Selin_2294 7.796e-69 237.0 COG2193@1|root,COG2193@2|Bacteria 2|Bacteria P ferroxidase activity bfr GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin CMS2_k127_4728883_0 1047013.AQSP01000126_gene2740 0.0 1109.0 COG2866@1|root,COG2866@2|Bacteria,2NQNH@2323|unclassified Bacteria 2|Bacteria E Zinc carboxypeptidase - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS2_k127_4728883_10 861299.J421_1752 2.041e-65 251.0 2DWGD@1|root,3407S@2|Bacteria,1ZV24@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg CMS2_k127_4728883_19 762984.HMPREF9445_03075 0.0008264 53.0 COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,2FMRZ@200643|Bacteroidia,4AKGC@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec CMS2_k127_4728883_13 378806.STAUR_5477 6.691e-38 150.0 COG1309@1|root,COG1309@2|Bacteria,1QX6M@1224|Proteobacteria,43BZ7@68525|delta/epsilon subdivisions,2X79X@28221|Deltaproteobacteria,2YVYY@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS2_k127_4728883_1 1191523.MROS_0484 5.02e-256 815.0 COG4773@1|root,COG4773@2|Bacteria 2|Bacteria P Receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,Plug,TonB_dep_Rec CMS2_k127_4728883_17 379066.GAU_1495 1.488e-18 97.0 COG0457@1|root,COG0457@2|Bacteria,1ZTCW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - - CMS2_k127_4728883_3 290397.Adeh_3036 9.489e-155 496.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YZRV@29|Myxococcales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS2_k127_4728883_6 1502850.FG91_00843 2.014e-117 398.0 COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria,2VFU8@28211|Alphaproteobacteria,2K77J@204457|Sphingomonadales 204457|Sphingomonadales S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS CMS2_k127_4728883_16 311424.DhcVS_1093 3.029e-21 96.0 2A4E9@1|root,2ZJRI@2|Bacteria,2GAVU@200795|Chloroflexi,34DG2@301297|Dehalococcoidia 301297|Dehalococcoidia - - - - - - - - - - - - - - - CMS2_k127_4728883_2 861299.J421_3340 4.081e-174 554.0 COG1960@1|root,COG1960@2|Bacteria,1ZSVZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K18244 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS2_k127_4728883_5 1229783.C273_03425 8.074e-131 424.0 COG4864@1|root,COG4864@2|Bacteria,1TPTD@1239|Firmicutes,4HAIX@91061|Bacilli,4GWZ7@90964|Staphylococcaceae 91061|Bacilli S UPF0365 protein yqfA - - - - - - - - - - - YdfA_immunity CMS2_k127_4728883_8 1499967.BAYZ01000190_gene3858 7.583e-87 303.0 COG1030@1|root,COG1030@2|Bacteria,2NNMU@2323|unclassified Bacteria 2|Bacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - NfeD,Peptidase_S49,SDH_sah CMS2_k127_4728883_7 1247024.JRLH01000001_gene740 5.102e-92 318.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase recQ GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind CMS2_k127_4753994_1 1183438.GKIL_4354 5.989e-142 482.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_4753994_3 251221.35211248 2.005e-25 109.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_4753994_0 344747.PM8797T_07534 1.639e-168 542.0 COG1073@1|root,COG1073@2|Bacteria,2IWT8@203682|Planctomycetes 203682|Planctomycetes S alpha beta - - - - - - - - - - - - - CMS2_k127_4753994_2 861299.J421_1342 6.171e-27 118.0 COG2207@1|root,COG2207@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - HTH_18 CMS2_k127_4767781_5 379066.GAU_2794 2.914e-05 55.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - DUF3857,Transglut_core CMS2_k127_4767781_3 404589.Anae109_0097 7.043e-06 57.0 298JI@1|root,2ZVQE@2|Bacteria,1P8JU@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_4767781_2 1459636.NTE_03342 2.494e-12 72.0 arCOG10350@1|root,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - CMS2_k127_4767781_6 1336249.JADW01000032_gene234 7.138e-05 47.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,4BDM8@82115|Rhizobiaceae 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 CMS2_k127_4767781_4 87626.PTD2_04391 1.053e-05 49.0 COG0823@1|root,COG0823@2|Bacteria,1R8X1@1224|Proteobacteria,1RZDN@1236|Gammaproteobacteria,2Q1CY@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_4767781_1 1123277.KB893172_gene658 2.611e-84 287.0 COG0726@1|root,COG0726@2|Bacteria,4NFJP@976|Bacteroidetes,47JTA@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolase family 9 - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CelD_N,Glyco_hydro_9,Polysacc_deac_1 CMS2_k127_4767781_0 861299.J421_2170 2.605e-114 391.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_4783748_0 1237149.C900_01894 1.368e-263 832.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,47KZ5@768503|Cytophagia 976|Bacteroidetes G PFAM Glycosyl Hydrolase - - - - - - - - - - - - Glyco_hydro_92 CMS2_k127_4783748_1 1121904.ARBP01000014_gene99 3.319e-203 644.0 COG3538@1|root,COG3538@2|Bacteria,4NGY6@976|Bacteroidetes,47JIR@768503|Cytophagia 976|Bacteroidetes S Pfam:DUF1237 - - - ko:K09704 - - - - ko00000 - - - Glyco_hydro_125 CMS2_k127_4783748_3 497964.CfE428DRAFT_2480 0.0002151 48.0 2AEIE@1|root,314DU@2|Bacteria,46WQ3@74201|Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - CMS2_k127_4785801_10 1173028.ANKO01000195_gene5937 5.308e-14 83.0 COG0457@1|root,COG0457@2|Bacteria,1G135@1117|Cyanobacteria,1H7GW@1150|Oscillatoriales 1117|Cyanobacteria O Tetratricopeptide repeat - - - - - - - - - - - - CHAT,TPR_12,TPR_7,TPR_8 CMS2_k127_4785801_3 208439.AJAP_18640 2.979e-62 223.0 COG0438@1|root,COG0438@2|Bacteria,2IC1A@201174|Actinobacteria,4E4GM@85010|Pseudonocardiales 201174|Actinobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 CMS2_k127_4785801_9 452637.Oter_1862 1.332e-20 98.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 CMS2_k127_4785801_11 585530.HMPREF0183_1087 1.315e-13 78.0 2B14M@1|root,31TIF@2|Bacteria,2H4U5@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF2938) - - - - - - - - - - - - DUF2938 CMS2_k127_4785801_2 1379270.AUXF01000002_gene1602 3.488e-73 264.0 2CESB@1|root,2Z8UZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_4785801_6 456442.Mboo_0445 6.264e-35 139.0 arCOG09455@1|root,arCOG09455@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - CMS2_k127_4785801_5 926550.CLDAP_20140 3.229e-40 153.0 COG2193@1|root,COG2193@2|Bacteria,2G6RN@200795|Chloroflexi 200795|Chloroflexi P Ferritin-like domain - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin CMS2_k127_4785801_13 318464.IO99_07585 7.04e-11 65.0 COG3743@1|root,COG3743@2|Bacteria,1VEZU@1239|Firmicutes,24RST@186801|Clostridia,36JSH@31979|Clostridiaceae 186801|Clostridia S PFAM TfoX - - - ko:K07343 - - - - ko00000 - - - TfoX_C CMS2_k127_4785801_4 1382306.JNIM01000001_gene1210 5.363e-54 201.0 COG2267@1|root,COG2267@2|Bacteria,2GBHH@200795|Chloroflexi 200795|Chloroflexi I Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 CMS2_k127_4785801_12 1265502.KB905992_gene77 6.809e-12 69.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VM41@28216|Betaproteobacteria,4AJ52@80864|Comamonadaceae 28216|Betaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve_3 CMS2_k127_4785801_7 526222.Desal_3639 9.045e-34 132.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,42U0I@68525|delta/epsilon subdivisions,2WR0Q@28221|Deltaproteobacteria,2MCK0@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 CMS2_k127_4785801_1 1379270.AUXF01000001_gene2371 4.794e-93 314.0 COG2801@1|root,COG2801@2|Bacteria,1ZUZC@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve_3 CMS2_k127_4785801_14 1047013.AQSP01000097_gene1952 2.008e-07 63.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,TolB_like CMS2_k127_4785801_0 861299.J421_5759 2.279e-131 448.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_4785801_15 96561.Dole_0659 6.047e-07 52.0 COG3514@1|root,COG3514@2|Bacteria,1PWSE@1224|Proteobacteria,43A9S@68525|delta/epsilon subdivisions,2WTC0@28221|Deltaproteobacteria,2MP7T@213118|Desulfobacterales 28221|Deltaproteobacteria S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - - CMS2_k127_4785801_8 861299.J421_6226 2.67e-29 121.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_482009_10 1234595.C725_1320 0.0005687 52.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TS6B@28211|Alphaproteobacteria,4BPB3@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Trypsin htrA2 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS2_k127_482009_4 1121091.AUMP01000001_gene154 3.84e-61 235.0 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli 91061|Bacilli KLT serine threonine protein kinase prkC GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase CMS2_k127_482009_3 1519464.HY22_01680 3.167e-74 276.0 COG0612@1|root,COG0612@2|Bacteria,1FENV@1090|Chlorobi 1090|Chlorobi S Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_482009_1 861299.J421_0916 1.411e-101 347.0 COG0612@1|root,COG0612@2|Bacteria,1ZSVK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_482009_2 309807.SRU_0542 1.276e-77 271.0 COG0115@1|root,COG0115@2|Bacteria,4NI83@976|Bacteroidetes 976|Bacteroidetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 CMS2_k127_482009_8 1536772.R70723_09930 2.126e-14 85.0 COG2363@1|root,COG2363@2|Bacteria,1VA79@1239|Firmicutes,4HKHG@91061|Bacilli,26Z1H@186822|Paenibacillaceae 91061|Bacilli S membrane ywdK - - - - - - - - - - - DUF423 CMS2_k127_482009_0 1114959.SZMC14600_07908 5.635e-117 393.0 COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4E1BE@85010|Pseudonocardiales 201174|Actinobacteria P PFAM Sodium sulfate symporter transmembrane region sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp CMS2_k127_482009_5 379066.GAU_1696 6.277e-43 165.0 COG0584@1|root,COG0584@2|Bacteria,1ZTTY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD CMS2_k127_482009_7 2074.JNYD01000022_gene1414 7.848e-36 145.0 COG1309@1|root,COG1309@2|Bacteria,2GKE2@201174|Actinobacteria,4E2WY@85010|Pseudonocardiales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_4,TetR_N CMS2_k127_482009_6 379066.GAU_1695 6.184e-36 143.0 COG1595@1|root,COG1595@2|Bacteria,1ZTKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_482009_9 1379270.AUXF01000006_gene198 3.493e-07 61.0 297VI@1|root,2ZV24@2|Bacteria,1ZU61@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_482275_0 861299.J421_0704 0.0 1026.0 COG0577@1|root,COG0577@2|Bacteria,1ZUI2@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_482275_2 335543.Sfum_3619 3.217e-158 504.0 COG0519@1|root,COG0519@2|Bacteria,1NR5X@1224|Proteobacteria,42YTH@68525|delta/epsilon subdivisions,2WUIJ@28221|Deltaproteobacteria,2MR8H@213462|Syntrophobacterales 28221|Deltaproteobacteria F GMP synthase C terminal domain - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GMP_synt_C,NAD_synthase CMS2_k127_482275_1 1499967.BAYZ01000080_gene919 3.98e-231 733.0 COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria 2|Bacteria S Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Glyco_hydro_127 CMS2_k127_482275_3 1195236.CTER_2098 1.054e-10 70.0 COG0641@1|root,COG0641@2|Bacteria,1TT6S@1239|Firmicutes,248QW@186801|Clostridia 186801|Clostridia C Radical SAM - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM CMS2_k127_4862553_1 1123504.JQKD01000030_gene4596 2.735e-49 182.0 COG2020@1|root,COG2020@2|Bacteria,1N3YJ@1224|Proteobacteria,2VT4V@28216|Betaproteobacteria,4AFU0@80864|Comamonadaceae 28216|Betaproteobacteria O Ergosterol biosynthesis ERG4/ERG24 family - - - - - - - - - - - - PEMT CMS2_k127_4862553_2 1538644.KO02_16195 2.411e-45 181.0 COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,1IQ2M@117747|Sphingobacteriia 976|Bacteroidetes S peptidase - - - - - - - - - - - - PA,Peptidase_M28 CMS2_k127_4862553_3 552811.Dehly_1434 5.09e-23 100.0 COG2026@1|root,COG2026@2|Bacteria,2G9FJ@200795|Chloroflexi 200795|Chloroflexi DJ PFAM plasmid stabilization system - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin CMS2_k127_4862553_8 1517416.IDAT_10430 5.147e-15 77.0 2E9PU@1|root,333W6@2|Bacteria,1N6VC@1224|Proteobacteria,1SCC9@1236|Gammaproteobacteria,2QH16@267893|Idiomarinaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - RHH_3 CMS2_k127_4862553_6 1121123.AUAO01000002_gene437 6.868e-19 93.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2TR7U@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0668 Small-conductance mechanosensitive channel - - - - - - - - - - - - MS_channel CMS2_k127_4862553_0 861299.J421_2179 5.896e-155 513.0 COG0308@1|root,COG0308@2|Bacteria,1ZUT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 CMS2_k127_4862553_9 697282.Mettu_1402 1.024e-06 53.0 2EKK5@1|root,33EA0@2|Bacteria,1NI6Y@1224|Proteobacteria,1SGCX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative addiction module component - - - - - - - - - - - - Unstab_antitox CMS2_k127_4862553_5 118168.MC7420_6605 2.07e-19 91.0 COG3668@1|root,COG3668@2|Bacteria,1G8WD@1117|Cyanobacteria,1HDM2@1150|Oscillatoriales 1117|Cyanobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin CMS2_k127_4862553_4 309807.SRU_0658 1.168e-21 97.0 COG5606@1|root,COG5606@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HTH_37 CMS2_k127_4862553_7 1040987.AZUY01000022_gene1530 2.081e-15 78.0 COG4679@1|root,COG4679@2|Bacteria,1MZC9@1224|Proteobacteria,2UKCG@28211|Alphaproteobacteria,43KV0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 CMS2_k127_494756_2 861299.J421_6034 1.927e-50 186.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS2_k127_494756_4 1519464.HY22_05255 2.068e-24 112.0 2ETC6@1|root,33KW3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_494756_3 452637.Oter_1824 4.077e-30 132.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - OmpA,PD40 CMS2_k127_494756_1 746697.Aeqsu_3165 1.365e-99 343.0 COG0793@1|root,COG0793@2|Bacteria,4NGGJ@976|Bacteroidetes,1HY6W@117743|Flavobacteriia 976|Bacteroidetes M peptidase S41 - - - - - - - - - - - - Peptidase_S41 CMS2_k127_494756_5 682795.AciX8_4833 1.259e-13 77.0 COG1695@1|root,COG1695@2|Bacteria,3Y8CC@57723|Acidobacteria,2JP3G@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_494756_0 861299.J421_6359 1.693e-123 429.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6359|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_4984732_7 861299.J421_3108 8.921e-53 188.0 2F044@1|root,33T7T@2|Bacteria,1ZTDC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_4984732_9 1288494.EBAPG3_15610 3.955e-40 156.0 COG1504@1|root,COG1504@2|Bacteria,1RGJ6@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 CMS2_k127_4984732_0 251221.35211765 1.659e-161 538.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_4984732_2 880073.Calab_0806 3.695e-128 416.0 COG1351@1|root,COG1351@2|Bacteria,2NPQ2@2323|unclassified Bacteria 2|Bacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 CMS2_k127_4984732_11 234267.Acid_2305 2.36e-29 120.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZC@57723|Acidobacteria 57723|Acidobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR CMS2_k127_4984732_1 251221.35211765 7.927e-156 527.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_4984732_12 756272.Plabr_0104 7.803e-26 118.0 COG0657@1|root,COG0657@2|Bacteria,2IXCK@203682|Planctomycetes 203682|Planctomycetes I COG0657 Esterase lipase - - - - - - - - - - - - Abhydrolase_3,EF-hand_5,Peptidase_S9 CMS2_k127_4984732_14 203122.Sde_0798 2.685e-05 56.0 COG0747@1|root,COG2356@1|root,COG2911@1|root,COG2982@1|root,COG3210@1|root,COG3506@1|root,COG3637@1|root,COG0747@2|Bacteria,COG2356@2|Bacteria,COG2911@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,COG3506@2|Bacteria,COG3637@2|Bacteria,1P8N9@1224|Proteobacteria,1SCTK@1236|Gammaproteobacteria,46D2E@72275|Alteromonadaceae 1236|Gammaproteobacteria M Cadherin repeats. - - - - - - - - - - - - Cadherin,DUF4347,DUF5122,He_PIG,OmpA_membrane CMS2_k127_4984732_10 373994.Riv7116_5381 5.219e-40 157.0 COG2050@1|root,COG2050@2|Bacteria,1G7HG@1117|Cyanobacteria 1117|Cyanobacteria Q Putative thioesterase (yiiD_Cterm) - - - - - - - - - - - - YiiD_C CMS2_k127_4984732_8 435591.BDI_3667 4.678e-45 171.0 COG0778@1|root,COG0778@2|Bacteria,4NP0K@976|Bacteroidetes,2FPFS@200643|Bacteroidia,22XYX@171551|Porphyromonadaceae 976|Bacteroidetes C Nitroreductase family - - - - - - - - - - - - Nitroreductase CMS2_k127_4984732_6 471854.Dfer_0286 6.41e-79 280.0 COG1082@1|root,COG1082@2|Bacteria,4NFQY@976|Bacteroidetes,47KP7@768503|Cytophagia 976|Bacteroidetes G Xylose isomerase domain protein TIM barrel - - - - - - - - - - - - AP_endonuc_2 CMS2_k127_4984732_4 666686.B1NLA3E_08530 9.986e-113 372.0 2C1EG@1|root,2Z7MZ@2|Bacteria,1V7SD@1239|Firmicutes,4HSP4@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - CMS2_k127_4984732_3 1122927.KB895414_gene5126 3.259e-120 394.0 COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,26QXS@186822|Paenibacillaceae 91061|Bacilli C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - - - - - - - - - - ADH_N,ADH_zinc_N_2 CMS2_k127_4984732_13 269797.Mbar_A0887 2.48e-12 74.0 arCOG05280@1|root,arCOG05280@2157|Archaea,2Y646@28890|Euryarchaeota,2NBF0@224756|Methanomicrobia 224756|Methanomicrobia - - - - - - - - - - - - - - - CMS2_k127_4984732_5 192952.MM_3157 1.509e-79 289.0 COG1680@1|root,arCOG00771@2157|Archaea 2157|Archaea V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - iAF692.Mbar_A1202 Beta-lactamase CMS2_k127_4984732_15 285535.JOEY01000035_gene3715 0.0001746 44.0 COG0477@1|root,COG0477@2|Bacteria,2H6BY@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 CMS2_k127_5133928_0 426114.THI_0610 4.454e-30 126.0 COG3428@1|root,COG3428@2|Bacteria,1N9PB@1224|Proteobacteria,2W341@28216|Betaproteobacteria,1KP17@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - bPH_2 CMS2_k127_5133928_3 247633.GP2143_03268 3.215e-09 65.0 2DDGP@1|root,2ZI0X@2|Bacteria,1P6R5@1224|Proteobacteria,1SU3B@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5133928_2 1047013.AQSP01000142_gene124 5.611e-11 74.0 COG3391@1|root,COG3391@2|Bacteria,2NQ4G@2323|unclassified Bacteria 2|Bacteria O NHL repeat - - - - - - - - - - - - DUF5128,NHL,TolB_like CMS2_k127_5133928_1 287986.DV20_19855 2.895e-15 83.0 COG0070@1|root,COG0070@2|Bacteria,2IB5W@201174|Actinobacteria,4ECR7@85010|Pseudonocardiales 201174|Actinobacteria E glutamate synthase - - - - - - - - - - - - - CMS2_k127_5153973_1 1167006.UWK_00988 3.256e-57 202.0 2BK9M@1|root,32EPT@2|Bacteria,1NC6I@1224|Proteobacteria,42XFJ@68525|delta/epsilon subdivisions,2WT5J@28221|Deltaproteobacteria,2MP6B@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5153973_2 502025.Hoch_3156 7.919e-32 133.0 2E13Z@1|root,32WJ8@2|Bacteria,1NYI6@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_5153973_3 1123248.KB893326_gene1348 2.499e-05 52.0 2DNNF@1|root,32Y92@2|Bacteria,4PMHZ@976|Bacteroidetes,1ITZJ@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_5153973_0 1382359.JIAL01000001_gene844 2.538e-303 951.0 COG0567@1|root,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria,2JICX@204432|Acidobacteriia 204432|Acidobacteriia C 2-oxoglutarate dehydrogenase, E1 - - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,OxoGdeHyase_C,Transket_pyr CMS2_k127_515408_11 395961.Cyan7425_3185 1.382e-14 75.0 COG1724@1|root,COG1724@2|Bacteria,1G7S1@1117|Cyanobacteria,3KIRS@43988|Cyanothece 1117|Cyanobacteria N PFAM YcfA-like protein - - - - - - - - - - - - HicA_toxin CMS2_k127_515408_10 1125863.JAFN01000001_gene824 2.722e-21 95.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MWV@68525|delta/epsilon subdivisions,2WJJZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria K filamentation induced by cAMP protein Fic - - - - - - - - - - - - Fic,Fic_N,HTH_24 CMS2_k127_515408_1 1121875.KB907549_gene1854 4.175e-128 425.0 COG1680@1|root,COG1680@2|Bacteria,4NGKK@976|Bacteroidetes,1HX0I@117743|Flavobacteriia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_515408_9 1380355.JNIJ01000048_gene33 1.438e-27 120.0 2AHTU@1|root,3186F@2|Bacteria,1NN1Q@1224|Proteobacteria,2UTGK@28211|Alphaproteobacteria,3K4KG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Antitoxin Phd_YefM, type II toxin-antitoxin system - - - - - - - - - - - - PhdYeFM_antitox CMS2_k127_515408_7 404589.Anae109_0256 6.428e-43 160.0 2DYDA@1|root,34983@2|Bacteria,1N38S@1224|Proteobacteria,4318W@68525|delta/epsilon subdivisions,2WWC4@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PIN domain - - - - - - - - - - - - PIN CMS2_k127_515408_6 1123276.KB893279_gene2202 7.491e-72 253.0 COG0823@1|root,COG0823@2|Bacteria,4NITC@976|Bacteroidetes,47R0N@768503|Cytophagia 976|Bacteroidetes U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40 CMS2_k127_515408_8 243231.GSU2274 2.23e-42 163.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42TNB@68525|delta/epsilon subdivisions,2WQIG@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Peptidyl-prolyl cis-trans fbp - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C CMS2_k127_515408_0 518766.Rmar_1830 1.263e-220 704.0 COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes,1FK1K@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 CMS2_k127_515408_3 1499967.BAYZ01000078_gene1000 6.814e-116 385.0 COG1748@1|root,COG1748@2|Bacteria,2NPF8@2323|unclassified Bacteria 2|Bacteria E Saccharopine dehydrogenase C-terminal domain - - - - - - - - - - - - ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP CMS2_k127_515408_2 1297742.A176_00961 7.231e-126 413.0 COG0451@1|root,COG0451@2|Bacteria,1RBSM@1224|Proteobacteria,42XUG@68525|delta/epsilon subdivisions,2WTSY@28221|Deltaproteobacteria,2YX8Q@29|Myxococcales 28221|Deltaproteobacteria GM NAD dependent epimerase/dehydratase family - - 1.3.1.45 ko:K05281 ko00943,ko01110,map00943,map01110 - R06562,R06563,R07747,R07751 RC00805 ko00000,ko00001,ko01000 - - - Epimerase CMS2_k127_515408_4 342949.PNA2_1571 4.728e-110 370.0 COG0733@1|root,arCOG04466@2157|Archaea,2XTG1@28890|Euryarchaeota,243E0@183968|Thermococci 183968|Thermococci P Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF CMS2_k127_515408_5 518766.Rmar_0382 1.514e-76 261.0 COG0572@1|root,COG0572@2|Bacteria,4NEEC@976|Bacteroidetes,1FIYA@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Phosphoribulokinase / Uridine kinase family udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK CMS2_k127_5169260_8 1122621.ATZA01000035_gene3614 5.974e-51 185.0 COG2272@1|root,COG2272@2|Bacteria,4NF5N@976|Bacteroidetes,1IQ9M@117747|Sphingobacteriia 976|Bacteroidetes I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase CMS2_k127_5169260_7 743722.Sph21_0133 5.887e-58 204.0 COG1917@1|root,COG1917@2|Bacteria,4NNR7@976|Bacteroidetes,1IT7P@117747|Sphingobacteriia 976|Bacteroidetes S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS2_k127_5169260_1 1121898.Q766_20530 4.749e-179 568.0 COG1075@1|root,COG1075@2|Bacteria,4NFSV@976|Bacteroidetes,1HY8D@117743|Flavobacteriia,2NYPJ@237|Flavobacterium 976|Bacteroidetes S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6 CMS2_k127_5169260_2 1192124.LIG30_4566 1.77e-160 513.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,1K10Z@119060|Burkholderiaceae 28216|Betaproteobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red CMS2_k127_5169260_5 1541065.JRFE01000004_gene5325 1.609e-104 349.0 COG2207@1|root,COG2207@2|Bacteria,1G0B1@1117|Cyanobacteria 1117|Cyanobacteria K PFAM AraC-type transcriptional regulator - - - - - - - - - - - - AraC_N,HTH_18 CMS2_k127_5169260_6 266779.Meso_3910 2.881e-88 303.0 COG0599@1|root,COG0599@2|Bacteria,1NN7W@1224|Proteobacteria,2TVCR@28211|Alphaproteobacteria,43PFY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD,Cupin_2 CMS2_k127_5169260_9 595460.RRSWK_07231 4.464e-45 168.0 COG4914@1|root,COG4914@2|Bacteria,2J4D4@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS2_k127_5169260_0 861299.J421_5626 0.0 1055.0 COG3408@1|root,COG3408@2|Bacteria 2|Bacteria G Glycogen debranching enzyme - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N CMS2_k127_5169260_4 102129.Lepto7375DRAFT_8356 1.916e-132 430.0 COG0584@1|root,COG0584@2|Bacteria,1G5CQ@1117|Cyanobacteria 1117|Cyanobacteria C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD CMS2_k127_5169260_10 861299.J421_0278 9.512e-39 152.0 COG4636@1|root,COG4636@2|Bacteria,1ZUYJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative restriction endonuclease - - - - - - - - - - - - Uma2 CMS2_k127_5169260_3 518766.Rmar_0025 5.561e-147 475.0 COG2730@1|root,COG2730@2|Bacteria,4NIBG@976|Bacteroidetes 976|Bacteroidetes G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_6,Cellulase CMS2_k127_5169260_11 331678.Cphamn1_1502 1.15e-37 147.0 COG2318@1|root,COG2318@2|Bacteria,1FF6X@1090|Chlorobi 1090|Chlorobi S DinB superfamily - - - - - - - - - - - - DinB_2 CMS2_k127_5169260_13 429009.Adeg_0748 8.684e-09 56.0 COG0702@1|root,COG0702@2|Bacteria 2|Bacteria GM epimerase - - - - - - - - - - - - NAD_binding_10,NmrA CMS2_k127_5169260_12 1120950.KB892759_gene6257 1.384e-18 87.0 COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria 201174|Actinobacteria C aldo keto reductase - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - Aldo_ket_red CMS2_k127_5215450_1 700598.Niako_2915 3.131e-65 233.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid MA20_39355 - - - - - - - - - - - Lactamase_B CMS2_k127_5215450_4 1254432.SCE1572_20525 8.398e-11 75.0 COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales 28221|Deltaproteobacteria S cellulose binding - - - - - - - - - - - - - CMS2_k127_5215450_3 1047013.AQSP01000058_gene2028 3.835e-11 75.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,TolB_like CMS2_k127_5215450_5 269799.Gmet_3051 2.855e-05 51.0 COG4479@1|root,COG4479@2|Bacteria,1PR77@1224|Proteobacteria,430IX@68525|delta/epsilon subdivisions,2WW2E@28221|Deltaproteobacteria 28221|Deltaproteobacteria S YozE SAM-like fold - - - - - - - - - - - - YozE_SAM_like CMS2_k127_5215450_2 493475.GARC_4257 6.033e-63 224.0 COG3023@1|root,COG3023@2|Bacteria 2|Bacteria V N-Acetylmuramoyl-L-alanine amidase ampD - 3.2.1.52,3.5.1.28 ko:K01207,ko:K01447,ko:K11066 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R04112,R05963,R07809,R07810,R10831 RC00049,RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Amidase_2,PG_binding_1 CMS2_k127_5215450_0 204669.Acid345_4142 2.953e-178 574.0 COG1505@1|root,COG1505@2|Bacteria,3Y2UH@57723|Acidobacteria,2JI70@204432|Acidobacteriia 204432|Acidobacteriia E Prolyl oligopeptidase - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N CMS2_k127_5216427_41 290315.Clim_2186 8.361e-22 106.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,1FDC1@1090|Chlorobi 1090|Chlorobi EG Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 CMS2_k127_5216427_33 497964.CfE428DRAFT_2480 1.675e-35 149.0 2AEIE@1|root,314DU@2|Bacteria,46WQ3@74201|Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - CMS2_k127_5216427_39 671143.DAMO_3023 2.68e-23 105.0 COG1848@1|root,COG1848@2|Bacteria 2|Bacteria G Toxic component of a toxin-antitoxin (TA) module. An RNase - GO:0005575,GO:0005576 - ko:K07064 - - - - ko00000 - - - PIN CMS2_k127_5216427_6 861299.J421_4263 5.195e-185 611.0 COG2234@1|root,COG2234@2|Bacteria,1ZT06@142182|Gemmatimonadetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS2_k127_5216427_16 436308.Nmar_1004 1.465e-134 448.0 COG0405@1|root,arCOG04053@2157|Archaea 2157|Archaea E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS2_k127_5216427_46 373994.Riv7116_6263 1.923e-06 54.0 2EENJ@1|root,338GE@2|Bacteria,1GAGG@1117|Cyanobacteria 1117|Cyanobacteria S TIGRFAM nif11-like leader peptide domain - - - - - - - - - - - - Nif11 CMS2_k127_5216427_13 1121481.AUAS01000002_gene3332 1.709e-148 496.0 COG1680@1|root,COG1680@2|Bacteria,4NEEP@976|Bacteroidetes,47KW2@768503|Cytophagia 976|Bacteroidetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_5216427_20 234267.Acid_4804 3.076e-98 334.0 COG2008@1|root,COG2008@2|Bacteria,3Y7Q8@57723|Acidobacteria 57723|Acidobacteria E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS2_k127_5216427_23 880073.Calab_3512 1.946e-83 302.0 COG2730@1|root,COG2730@2|Bacteria,2NPPH@2323|unclassified Bacteria 2|Bacteria G Cellulase (glycosyl hydrolase family 5) - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_6,Cellulase CMS2_k127_5216427_44 998674.ATTE01000001_gene2156 3.717e-10 73.0 COG1028@1|root,COG3693@1|root,COG1028@2|Bacteria,COG3693@2|Bacteria,1MWC8@1224|Proteobacteria,1S1X8@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - CBM9_1 CMS2_k127_5216427_5 1122931.AUAE01000016_gene2680 8.257e-191 629.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,2FS4M@200643|Bacteroidia,2309R@171551|Porphyromonadaceae 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_5216427_10 1408422.JHYF01000001_gene3063 1.007e-165 535.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,36DFC@31979|Clostridiaceae 186801|Clostridia S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF CMS2_k127_5216427_7 234267.Acid_3373 1.66e-175 561.0 COG1282@1|root,COG1282@2|Bacteria,3Y42H@57723|Acidobacteria 57723|Acidobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB CMS2_k127_5216427_38 234267.Acid_3374 2.323e-23 105.0 COG3288@1|root,COG3288@2|Bacteria,3Y5PH@57723|Acidobacteria 57723|Acidobacteria C 4TM region of pyridine nucleotide transhydrogenase, mitoch - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM CMS2_k127_5216427_14 1183438.GKIL_4354 5.297e-143 490.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5216427_40 234267.Acid_2305 2.09e-22 100.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZC@57723|Acidobacteria 57723|Acidobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR CMS2_k127_5216427_42 1521187.JPIM01000029_gene1545 2.009e-13 77.0 COG1451@1|root,COG1451@2|Bacteria,2GAPI@200795|Chloroflexi,377EJ@32061|Chloroflexia 32061|Chloroflexia S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 CMS2_k127_5216427_12 234267.Acid_3470 7.509e-150 508.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5216427_17 518766.Rmar_1743 5.688e-116 383.0 COG1082@1|root,COG1082@2|Bacteria,4NG1K@976|Bacteroidetes 976|Bacteroidetes G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 CMS2_k127_5216427_24 335543.Sfum_2693 9.685e-79 279.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,2MS09@213462|Syntrophobacterales 28221|Deltaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE CMS2_k127_5216427_28 1047013.AQSP01000115_gene339 5.356e-52 189.0 295NE@1|root,2ZSZT@2|Bacteria 2|Bacteria S DoxX - - 1.8.5.2 ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - DoxX CMS2_k127_5216427_1 1047013.AQSP01000115_gene340 6.265e-221 696.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA CMS2_k127_5216427_3 1047013.AQSP01000115_gene341 2.392e-202 637.0 COG0673@1|root,COG0673@2|Bacteria,2NQ5E@2323|unclassified Bacteria 2|Bacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS2_k127_5216427_37 65393.PCC7424_0275 2.154e-24 116.0 COG0738@1|root,COG0738@2|Bacteria,1GK8Y@1117|Cyanobacteria,3KJKK@43988|Cyanothece 1117|Cyanobacteria G PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 CMS2_k127_5216427_35 653045.Strvi_2629 1.399e-34 141.0 COG3828@1|root,COG3828@2|Bacteria,2GJW0@201174|Actinobacteria 201174|Actinobacteria M Trehalose utilisation - - - ko:K09992 - - - - ko00000 - - - DUF1080,ThuA CMS2_k127_5216427_22 502025.Hoch_4956 7.741e-91 310.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2YU7R@29|Myxococcales 28221|Deltaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C CMS2_k127_5216427_0 861299.J421_6304 0.0 1449.0 COG4447@1|root,COG4447@2|Bacteria,1ZUBH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 CMS2_k127_5216427_26 1047013.AQSP01000131_gene1826 1.64e-62 231.0 COG0771@1|root,COG0771@2|Bacteria,2NPCH@2323|unclassified Bacteria 2|Bacteria M Mur ligase middle domain murD - 3.4.21.10,6.3.2.13,6.3.2.9 ko:K01317,ko:K01925,ko:K01928,ko:K01932 ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100 - R02783,R02788 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01002,ko01011,ko04131 - - - DUF1727,Mur_ligase_C,Mur_ligase_M CMS2_k127_5216427_34 1047013.AQSP01000131_gene1825 1.227e-34 137.0 29EG8@1|root,334DW@2|Bacteria,2NPTE@2323|unclassified Bacteria 2|Bacteria S Capsule biosynthesis CapC capC - - ko:K22116 - - - - ko00000 - - - Caps_synth_CapC CMS2_k127_5216427_25 1047013.AQSP01000131_gene1824 6.355e-70 256.0 28JNG@1|root,2Z9ES@2|Bacteria,2NPDF@2323|unclassified Bacteria 2|Bacteria - - pgsW - - - - - - - - - - - - CMS2_k127_5216427_31 1047013.AQSP01000131_gene1820 6.16e-45 171.0 28NEN@1|root,2ZQSB@2|Bacteria,2NRHN@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_5216427_9 1047013.AQSP01000131_gene1822 9.517e-171 545.0 COG4666@1|root,COG4666@2|Bacteria,2NQNY@2323|unclassified Bacteria 2|Bacteria S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - - CMS2_k127_5216427_45 457415.HMPREF1006_01318 3.341e-08 56.0 2EQNC@1|root,33I8A@2|Bacteria,3TBT0@508458|Synergistetes 508458|Synergistetes - - - - - - - - - - - - - - - CMS2_k127_5216427_8 1047013.AQSP01000131_gene1823 2.078e-173 554.0 COG3608@1|root,COG3608@2|Bacteria,2NQNJ@2323|unclassified Bacteria 2|Bacteria S succinylglutamate desuccinylase aspartoacylase pgp1 - - ko:K06987,ko:K07402 - - - - ko00000 - - - AstE_AspA,Peptidase_M99,Peptidase_M99_C,Peptidase_M99_m CMS2_k127_5216427_4 1047013.AQSP01000134_gene1376 5.454e-199 637.0 COG4690@1|root,COG4690@2|Bacteria 2|Bacteria E dipeptidase activity - - - - - - - - - - - - Peptidase_C69 CMS2_k127_5216427_2 1379270.AUXF01000002_gene1134 2.753e-213 685.0 COG2091@1|root,COG2091@2|Bacteria,1ZU9H@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - CMS2_k127_5216427_15 861299.J421_1321 4.973e-135 436.0 COG0115@1|root,COG0115@2|Bacteria,1ZTH5@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 CMS2_k127_5216427_19 861299.J421_6340 1.122e-100 334.0 COG1028@1|root,COG1028@2|Bacteria,1ZTIT@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS2_k127_5216427_30 861299.J421_6341 9.338e-48 175.0 COG1917@1|root,COG1917@2|Bacteria,1ZTY8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Cupin domain - - - - - - - - - - - - Cupin_2 CMS2_k127_5216427_36 1047013.AQSP01000092_gene313 1.869e-33 131.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 CMS2_k127_5216427_27 861299.J421_6200 4.401e-56 210.0 COG1680@1|root,COG1680@2|Bacteria,1ZU44@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_5216427_32 1408473.JHXO01000012_gene341 2.366e-38 146.0 COG0599@1|root,COG0599@2|Bacteria,4NYAJ@976|Bacteroidetes 976|Bacteroidetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD CMS2_k127_5216427_29 1408433.JHXV01000027_gene3706 1.77e-50 191.0 COG0702@1|root,COG0702@2|Bacteria,4NFUX@976|Bacteroidetes 976|Bacteroidetes GM SPTR NmrA family protein - - - - - - - - - - - - NAD_binding_10 CMS2_k127_5216427_11 204669.Acid345_1052 1.41e-161 537.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia 204432|Acidobacteriia KLT Tetratricopeptide repeats - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C CMS2_k127_5216427_21 1123057.P872_00880 1.634e-93 320.0 COG2355@1|root,COG2355@2|Bacteria,4NDX6@976|Bacteroidetes,47K2D@768503|Cytophagia 976|Bacteroidetes E Membrane dipeptidase (Peptidase family M19) - - - - - - - - - - - - Peptidase_M19 CMS2_k127_5216427_43 1410608.JNKX01000028_gene2616 5.368e-11 70.0 29F7N@1|root,3025B@2|Bacteria,4NNR8@976|Bacteroidetes,2G2G7@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - NfeD CMS2_k127_5216427_18 1201290.M902_1809 3.105e-109 366.0 COG2268@1|root,COG2268@2|Bacteria,1QIR4@1224|Proteobacteria,42Q0N@68525|delta/epsilon subdivisions,2WJDJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Band 7 protein - - - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot CMS2_k127_5225459_2 1047013.AQSP01000131_gene1797 1.137e-44 167.0 COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria 2|Bacteria U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS2_k127_5225459_0 1187848.AJYQ01000004_gene154 1.588e-98 333.0 COG0438@1|root,COG0438@2|Bacteria,1MWSZ@1224|Proteobacteria,1RMQP@1236|Gammaproteobacteria,1XWTF@135623|Vibrionales 135623|Vibrionales M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 CMS2_k127_5225459_1 396588.Tgr7_1823 1.909e-56 209.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds yclE GO:0003674,GO:0003824,GO:0016787 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 CMS2_k127_5225459_5 444157.Tneu_1478 4.773e-07 57.0 COG0778@1|root,arCOG00288@2157|Archaea,2XQMS@28889|Crenarchaeota 28889|Crenarchaeota C PFAM Nitroreductase - - - - - - - - - - - - Nitroreductase CMS2_k127_5225459_4 59374.Fisuc_1608 2.06e-19 97.0 COG0406@1|root,COG4704@1|root,COG0406@2|Bacteria,COG4704@2|Bacteria 2|Bacteria G alpha-ribazole phosphatase activity - - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - Fib_succ_major,His_Phos_1 CMS2_k127_5225459_3 1463857.JOFZ01000074_gene2428 6.403e-21 96.0 COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - Transposase_mut CMS2_k127_5255638_2 1387312.BAUS01000002_gene983 2.735e-12 73.0 COG3391@1|root,COG3391@2|Bacteria,1NFEK@1224|Proteobacteria,2W53Z@28216|Betaproteobacteria 28216|Betaproteobacteria S amine dehydrogenase activity - - - - - - - - - - - - - CMS2_k127_5255638_0 448385.sce6364 2.329e-119 402.0 COG5492@1|root,COG5492@2|Bacteria 2|Bacteria N domain, Protein - - - - - - - - - - - - Big_2,CarboxypepD_reg,Cohesin CMS2_k127_5268395_37 290317.Cpha266_0842 1.709e-32 136.0 COG1132@1|root,COG1132@2|Bacteria 2|Bacteria V (ABC) transporter yfiB - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran CMS2_k127_5268395_2 861299.J421_3741 1.274e-270 846.0 COG1217@1|root,COG1217@2|Bacteria,1ZT8A@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Elongation factor G C-terminus - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 CMS2_k127_5268395_17 861299.J421_3989 1.733e-100 344.0 COG1253@1|root,COG1253@2|Bacteria,1ZT0D@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 CMS2_k127_5268395_21 861299.J421_3744 3.943e-95 321.0 COG1995@1|root,COG1995@2|Bacteria,1ZT2S@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pyridoxal phosphate biosynthetic protein PdxA - - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA CMS2_k127_5268395_41 1122176.KB903532_gene2570 6.174e-23 113.0 COG0760@1|root,COG0760@2|Bacteria,4NEW0@976|Bacteroidetes,1IQB4@117747|Sphingobacteriia 976|Bacteroidetes O peptidylprolyl isomerase surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N_3 CMS2_k127_5268395_48 1382359.JIAL01000001_gene2437 4.762e-14 85.0 COG0760@1|root,COG0760@2|Bacteria,3Y3BW@57723|Acidobacteria,2JIP1@204432|Acidobacteriia 204432|Acidobacteriia O Peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_3 CMS2_k127_5268395_38 861299.J421_3746 4.22e-32 141.0 COG0760@1|root,COG0760@2|Bacteria,1ZT5S@142182|Gemmatimonadetes 142182|Gemmatimonadetes M PPIC-type PPIASE domain - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 CMS2_k127_5268395_4 518766.Rmar_2754 1.398e-227 745.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,1FIP1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF CMS2_k127_5268395_33 1379270.AUXF01000003_gene3697 2.523e-61 235.0 COG2304@1|root,COG2304@2|Bacteria,1ZT05@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA CMS2_k127_5268395_24 861299.J421_3749 7.776e-87 296.0 COG1721@1|root,COG1721@2|Bacteria,1ZT0H@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 CMS2_k127_5268395_32 661478.OP10G_2288 9.341e-65 241.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - FtsX,PA,Peptidase_M28 CMS2_k127_5268395_1 861299.J421_3751 2.673e-290 900.0 COG0481@1|root,COG0481@2|Bacteria,1ZTGT@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,LepA_C CMS2_k127_5268395_13 861299.J421_3753 2.545e-117 386.0 COG1940@1|root,COG1940@2|Bacteria,1ZT66@142182|Gemmatimonadetes 142182|Gemmatimonadetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK CMS2_k127_5268395_20 861299.J421_3754 2.071e-96 325.0 COG0524@1|root,COG0524@2|Bacteria,1ZTFD@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - - - - - - - - - - - CMS2_k127_5268395_16 1379270.AUXF01000003_gene3690 1.399e-101 340.0 COG0643@1|root,COG0643@2|Bacteria,1ZSPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Histidine kinase-like ATPases - - - - - - - - - - - - - CMS2_k127_5268395_39 379066.GAU_2157 4.207e-30 125.0 2EFCU@1|root,3395Q@2|Bacteria,1ZTVZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5268395_28 861299.J421_3759 5.863e-81 276.0 COG2884@1|root,COG2884@2|Bacteria,1ZTHQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D ABC transporter - - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran CMS2_k127_5268395_27 861299.J421_3760 1.331e-82 283.0 COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Part of the ABC transporter FtsEX involved in - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - CMS2_k127_5268395_31 861299.J421_3761 3.197e-65 238.0 COG4942@1|root,COG4942@2|Bacteria,1ZSU6@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 CMS2_k127_5268395_49 391625.PPSIR1_08207 9.328e-14 81.0 COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,42MYP@68525|delta/epsilon subdivisions 1224|Proteobacteria K regulatory protein TetR - - - - - - - - - - - - DUF1956,TetR_N CMS2_k127_5268395_47 1000565.METUNv1_01467 3.951e-14 85.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,2KV30@206389|Rhodocyclales 206389|Rhodocyclales M Outer membrane efflux protein - - - ko:K18903 - M00698 - - ko00000,ko00002,ko01504,ko02000 1.B.17.3.3 - - OEP CMS2_k127_5268395_19 1123368.AUIS01000024_gene946 8.376e-98 330.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RS3I@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Secretion protein yhiI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS2_k127_5268395_15 1123368.AUIS01000024_gene947 2.98e-108 362.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NDPN@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_5268395_11 1123368.AUIS01000024_gene948 6.279e-122 401.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2NCCI@225057|Acidithiobacillales 225057|Acidithiobacillales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 CMS2_k127_5268395_8 1123368.AUIS01000024_gene949 5.047e-129 422.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,2NBU9@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS2_k127_5268395_9 1123368.AUIS01000024_gene950 2.354e-122 409.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1SYDD@1236|Gammaproteobacteria,2NCJF@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS2_k127_5268395_50 309801.trd_0052 1.053e-13 80.0 COG0789@1|root,COG4974@1|root,COG0789@2|Bacteria,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family VV0135 - - ko:K04763,ko:K19591 - M00769 - - ko00000,ko00002,ko01504,ko03000,ko03036 - - - MerR_1,Methyltransf_25,Phage_int_SAM_1,Phage_integrase CMS2_k127_5268395_34 321327.CYA_0908 1.593e-57 207.0 COG2518@1|root,COG2518@2|Bacteria,1G5KC@1117|Cyanobacteria,1H0H3@1129|Synechococcus 1117|Cyanobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS2_k127_5268395_18 861299.J421_3762 1.451e-98 329.0 COG0648@1|root,COG0648@2|Bacteria,1ZSY0@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 CMS2_k127_5268395_29 518766.Rmar_1241 1.537e-75 268.0 COG1785@1|root,COG1785@2|Bacteria,4NG3D@976|Bacteroidetes,1FIWB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Belongs to the alkaline phosphatase family - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase CMS2_k127_5268395_35 880073.Calab_1819 3.989e-56 213.0 COG3170@1|root,COG3170@2|Bacteria,2NPXD@2323|unclassified Bacteria 2|Bacteria NU Tfp pilus assembly protein FimV - - 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - DUF4157,Pkinase CMS2_k127_5268395_22 880073.Calab_1818 7.34e-93 316.0 COG0803@1|root,COG0803@2|Bacteria,2NPH3@2323|unclassified Bacteria 2|Bacteria P Belongs to the bacterial solute-binding protein 9 family znuA - - ko:K02077,ko:K09815,ko:K09818 ko02010,map02010 M00242,M00243,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ZnuA CMS2_k127_5268395_30 880073.Calab_1817 2.322e-72 254.0 COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria 2|Bacteria U ABC 3 transport family znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 CMS2_k127_5268395_7 861299.J421_3775 3.652e-132 434.0 COG1078@1|root,COG1078@2|Bacteria,1ZT3F@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD CMS2_k127_5268395_55 379066.GAU_2172 4.529e-06 52.0 2CFMP@1|root,2ZEHG@2|Bacteria,1ZU7I@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5268395_26 1379270.AUXF01000003_gene3674 2.264e-83 289.0 COG0631@1|root,COG0631@2|Bacteria,1ZSYG@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS2_k127_5268395_52 1121934.AUDX01000012_gene1996 7.232e-09 68.0 COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4FNUE@85023|Microbacteriaceae 201174|Actinobacteria T Forkhead associated domain fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - - - - - - - - - - FHA,Yop-YscD_cpl CMS2_k127_5268395_54 525909.Afer_0092 6.708e-08 65.0 COG1716@1|root,COG1716@2|Bacteria,2HG8X@201174|Actinobacteria,4CN6T@84992|Acidimicrobiia 84992|Acidimicrobiia T Protein of unknown function (DUF2662) - - - - - - - - - - - - DUF3662,FHA CMS2_k127_5268395_42 448385.sce5866 8.506e-23 111.0 COG0392@1|root,COG0392@2|Bacteria,1R959@1224|Proteobacteria 1224|Proteobacteria S integral membrane protein - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM CMS2_k127_5268395_0 861299.J421_3780 0.0 1144.0 COG0178@1|root,COG0178@2|Bacteria,1ZT1W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran CMS2_k127_5268395_45 113395.AXAI01000002_gene5326 1.224e-18 94.0 COG1596@1|root,COG1596@2|Bacteria,1MXYS@1224|Proteobacteria,2U93S@28211|Alphaproteobacteria,3JYCM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M SLBB domain - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB CMS2_k127_5268395_43 680198.SCAB_84881 7.415e-21 107.0 COG0596@1|root,COG0596@2|Bacteria,2GNBX@201174|Actinobacteria 201174|Actinobacteria I Belongs to the peptidase S33 family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 CMS2_k127_5268395_57 290397.Adeh_3077 0.0006473 47.0 COG0484@1|root,COG0484@2|Bacteria,1QYGD@1224|Proteobacteria,43CCI@68525|delta/epsilon subdivisions,2X7NG@28221|Deltaproteobacteria,2Z1CZ@29|Myxococcales 28221|Deltaproteobacteria C TIGRFAM cytochrome C family protein - - - - - - - - - - - - GSu_C4xC__C2xCH CMS2_k127_5268395_56 632518.Calow_2170 0.0006171 45.0 COG2331@1|root,COG2331@2|Bacteria,1VH3W@1239|Firmicutes,24N2H@186801|Clostridia,42HEJ@68295|Thermoanaerobacterales 186801|Clostridia S TIGRFAM regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 CMS2_k127_5268395_53 264732.Moth_0829 3.111e-08 57.0 COG2331@1|root,COG2331@2|Bacteria,1VKRT@1239|Firmicutes,24VXJ@186801|Clostridia 186801|Clostridia S Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 CMS2_k127_5268395_46 926560.KE387027_gene552 4.998e-16 82.0 COG0707@1|root,COG0707@2|Bacteria 2|Bacteria M undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity - - 2.4.1.315 ko:K03429 ko00561,ko01100,map00561,map01100 - R02689,R04377 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT28 - Glyco_tran_28_C,Glycos_transf_1,MGDG_synth CMS2_k127_5268395_36 991.IW20_01815 1.003e-34 139.0 2DEWU@1|root,2ZPJP@2|Bacteria,4NPJW@976|Bacteroidetes,1I25Z@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_5268395_12 1121440.AUMA01000005_gene2718 7.998e-120 392.0 COG0730@1|root,COG0730@2|Bacteria,1PYDH@1224|Proteobacteria,42P28@68525|delta/epsilon subdivisions,2WK6D@28221|Deltaproteobacteria,2M87J@213115|Desulfovibrionales 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE CMS2_k127_5268395_23 1196323.ALKF01000203_gene3817 9.567e-92 312.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - ChW,Peptidase_S8 CMS2_k127_5268395_3 1124780.ANNU01000036_gene34 1.169e-227 730.0 COG0531@1|root,COG0531@2|Bacteria,4NFFX@976|Bacteroidetes,47M9P@768503|Cytophagia 976|Bacteroidetes E Amino acid permease - - - - - - - - - - - - AA_permease CMS2_k127_5268395_5 1191523.MROS_1006 5.929e-183 601.0 COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria 2|Bacteria T AMP binding ybaT GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169 - ko:K03322,ko:K07076,ko:K09944,ko:K16263 - - - - ko00000,ko02000 2.A.3.13,2.A.55.2.6,2.A.55.3 - - AA_permease_2,Usp CMS2_k127_5268395_40 1191523.MROS_1008 1.312e-26 117.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport cmpX - - - - - - - - - - - MS_channel,TM_helix CMS2_k127_5268395_10 1173021.ALWA01000010_gene1477 4.782e-122 402.0 COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria 1117|Cyanobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA CMS2_k127_5268395_25 518766.Rmar_0142 5.657e-85 317.0 COG1672@1|root,COG1672@2|Bacteria,4NN64@976|Bacteroidetes 976|Bacteroidetes S PFAM Archaeal ATPase - - - - - - - - - - - - - CMS2_k127_5268395_14 518766.Rmar_0141 2.098e-109 367.0 COG0668@1|root,COG0668@2|Bacteria,4NMNE@976|Bacteroidetes 976|Bacteroidetes M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel CMS2_k127_5268395_51 452637.Oter_3355 1.982e-11 75.0 COG3746@1|root,COG3746@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Porin_O_P CMS2_k127_5268395_44 448385.sce0123 8.274e-19 98.0 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria,2Z0V8@29|Myxococcales 28221|Deltaproteobacteria T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp CMS2_k127_5268395_6 472759.Nhal_0217 1.937e-149 520.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,1WWU1@135613|Chromatiales 135613|Chromatiales S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB CMS2_k127_5286491_1 317025.Tcr_1072 5.756e-50 184.0 COG1680@1|root,COG1680@2|Bacteria,1PF8A@1224|Proteobacteria,1SWQW@1236|Gammaproteobacteria,462UZ@72273|Thiotrichales 72273|Thiotrichales V PFAM beta-lactamase - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase CMS2_k127_5286491_9 1120965.AUBV01000003_gene410 3.651e-07 58.0 2DPHI@1|root,3323M@2|Bacteria,4P1NC@976|Bacteroidetes,47TYB@768503|Cytophagia 976|Bacteroidetes S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase CMS2_k127_5286491_5 870187.Thini_3946 5.269e-17 81.0 2EGMT@1|root,33ADY@2|Bacteria,1NH3I@1224|Proteobacteria,1SGAI@1236|Gammaproteobacteria,46397@72273|Thiotrichales 72273|Thiotrichales S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N CMS2_k127_5286491_8 913865.DOT_3333 1.665e-09 59.0 2ES6V@1|root,33JRM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_5286491_2 1089547.KB913013_gene1392 8.388e-41 156.0 COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes,47QGD@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1572) - - - - - - - - - - - - DUF1572 CMS2_k127_5286491_10 338969.Rfer_3466 2.317e-06 55.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Abhydrolase_1,DUF4440,SnoaL_2,SnoaL_3,YkuD CMS2_k127_5286491_7 1101190.ARWB01000001_gene3202 6.494e-10 66.0 2DSXN@1|root,33HV3@2|Bacteria,1NI61@1224|Proteobacteria,2UW0C@28211|Alphaproteobacteria 28211|Alphaproteobacteria S YcxB-like protein - - - - - - - - - - - - YcxB CMS2_k127_5286491_4 1117319.PSPO_20201 1.975e-17 89.0 COG1695@1|root,COG1695@2|Bacteria,1N4DF@1224|Proteobacteria,1SBH1@1236|Gammaproteobacteria,2Q31Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K transcriptional regulators - - - - - - - - - - - - PadR CMS2_k127_5286491_0 861299.J421_0601 3.348e-143 488.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5286491_6 591158.SSMG_06781 6.056e-12 74.0 COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria 201174|Actinobacteria K belongs to the sigma-70 factor family, ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2,SnoaL_2 CMS2_k127_5286491_11 211165.AJLN01000107_gene5633 2.92e-05 51.0 COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,1JGWQ@1189|Stigonemataceae 1117|Cyanobacteria M OmpA family - - - ko:K02557,ko:K03286 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1,1.B.6 - - OmpA CMS2_k127_5341419_37 1379270.AUXF01000001_gene1966 2.25e-90 315.0 2CESB@1|root,2Z8UZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_5341419_23 518766.Rmar_1488 5.777e-137 441.0 COG1313@1|root,COG1313@2|Bacteria 2|Bacteria C radical SAM domain protein PflX - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM CMS2_k127_5341419_62 861299.J421_1295 1.338e-36 145.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_5341419_5 518766.Rmar_0638 2.067e-265 832.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1FIMH@1100069|Bacteroidetes Order II. Incertae sedis 2|Bacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF CMS2_k127_5341419_72 518766.Rmar_0637 7.319e-16 92.0 2FDJV@1|root,345M5@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_5341419_34 1254432.SCE1572_51570 3.218e-95 322.0 COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,42QW2@68525|delta/epsilon subdivisions,2WMRN@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos CMS2_k127_5341419_46 909663.KI867149_gene3210 4.058e-65 227.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,43ACP@68525|delta/epsilon subdivisions,2WW7Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit CMS2_k127_5341419_13 1191523.MROS_1137 4.052e-181 600.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_5341419_32 234267.Acid_5671 1.644e-110 368.0 COG2423@1|root,COG2423@2|Bacteria,3Y82U@57723|Acidobacteria 57723|Acidobacteria E PFAM ornithine cyclodeaminase mu-crystallin - - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall CMS2_k127_5341419_18 518766.Rmar_1907 4.201e-156 508.0 COG2866@1|root,COG2866@2|Bacteria,4NF5T@976|Bacteroidetes 976|Bacteroidetes E Carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS2_k127_5341419_51 1379270.AUXF01000005_gene495 1.399e-59 214.0 COG0664@1|root,COG0664@2|Bacteria,1ZTHA@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, cAMP Regulatory protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding CMS2_k127_5341419_24 379066.GAU_3769 5.948e-134 437.0 COG2355@1|root,COG2355@2|Bacteria,1ZT5A@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 CMS2_k127_5341419_0 251221.35211322 0.0 1166.0 COG2866@1|root,COG2866@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS2_k127_5341419_79 861299.J421_2429 0.0002878 52.0 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C CMS2_k127_5341419_68 67593.Physo143949 1.718e-22 109.0 COG0515@1|root,COG0666@1|root,KOG0192@2759|Eukaryota,KOG0504@2759|Eukaryota,3QDVJ@4776|Peronosporales 4776|Peronosporales T Protein tyrosine kinase - - - - - - - - - - - - Ank_2,Ank_4,Pkinase_Tyr CMS2_k127_5341419_64 886293.Sinac_0789 4.799e-33 136.0 COG1266@1|root,COG1266@2|Bacteria,2J0ZS@203682|Planctomycetes 203682|Planctomycetes S CAAX amino terminal protease - - - ko:K07052 - - - - ko00000 - - - Abi CMS2_k127_5341419_4 335543.Sfum_2336 5.734e-275 854.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,43DIW@68525|delta/epsilon subdivisions,2X8Q7@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumB - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C CMS2_k127_5341419_55 880073.Calab_3333 4.957e-54 208.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - - CMS2_k127_5341419_29 1121035.AUCH01000012_gene3048 4.082e-124 411.0 COG0668@1|root,COG0668@2|Bacteria,1MVX9@1224|Proteobacteria,2VHK5@28216|Betaproteobacteria,2KXV3@206389|Rhodocyclales 206389|Rhodocyclales M Mechanosensitive ion channel - - - ko:K16053 - - - - ko00000,ko02000 1.A.23.4.5 - - MS_channel CMS2_k127_5341419_66 706587.Desti_3609 5.262e-31 132.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,42TJM@68525|delta/epsilon subdivisions,2WQGN@28221|Deltaproteobacteria,2MS6F@213462|Syntrophobacterales 28221|Deltaproteobacteria F PFAM Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase CMS2_k127_5341419_57 1047013.AQSP01000130_gene1852 7.646e-53 196.0 COG0730@1|root,COG0730@2|Bacteria,2NQW7@2323|unclassified Bacteria 2|Bacteria S Sulfite exporter TauE/SafE VVA0548 - - ko:K07090 - - - - ko00000 - - - TauE CMS2_k127_5341419_2 502025.Hoch_6444 4.109e-288 897.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2WWD4@28221|Deltaproteobacteria,2YTYG@29|Myxococcales 28221|Deltaproteobacteria S oligopeptide transporter, OPT family - - - - - - - - - - - - OPT CMS2_k127_5341419_45 1341151.ASZU01000015_gene2040 1.173e-71 261.0 COG3227@1|root,COG3227@2|Bacteria,1TSGU@1239|Firmicutes,4HC7W@91061|Bacilli,27CRY@186824|Thermoactinomycetaceae 91061|Bacilli E Fungalysin metallopeptidase (M36) - - - - - - - - - - - - FTP,PepSY,Peptidase_M36 CMS2_k127_5341419_48 1237149.C900_05249 2.41e-63 224.0 COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,47PK1@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA,PD40 CMS2_k127_5341419_38 391625.PPSIR1_22871 3.04e-86 297.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42ZVA@68525|delta/epsilon subdivisions,2WVEX@28221|Deltaproteobacteria,2YU4Z@29|Myxococcales 28221|Deltaproteobacteria C cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C CMS2_k127_5341419_33 861299.J421_3108 4.56e-100 336.0 2F044@1|root,33T7T@2|Bacteria,1ZTDC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5341419_27 1047013.AQSP01000121_gene2702 3.047e-130 440.0 COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria 2|Bacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 CMS2_k127_5341419_70 439235.Dalk_0308 6.552e-20 94.0 COG2204@1|root,COG2204@2|Bacteria,1QW8K@1224|Proteobacteria,42V8F@68525|delta/epsilon subdivisions,2X2ZW@28221|Deltaproteobacteria,2MNZF@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS2_k127_5341419_36 314285.KT71_14494 2.548e-94 314.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1SK5X@1236|Gammaproteobacteria,1J8FM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 CMS2_k127_5341419_6 1379270.AUXF01000001_gene2683 8.3e-253 796.0 COG0008@1|root,COG0008@2|Bacteria,1ZTAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (E and Q), anti-codon binding domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C CMS2_k127_5341419_41 1379270.AUXF01000007_gene968 9.774e-81 290.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene968|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_5341419_78 359.CN09_07895 1.68e-06 60.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,4BAI7@82115|Rhizobiaceae 28211|Alphaproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Peptidase_M50 CMS2_k127_5341419_61 1237149.C900_03285 2.378e-37 147.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_5341419_53 880073.Calab_3376 7.429e-57 207.0 COG3295@1|root,COG3295@2|Bacteria 2|Bacteria C Protein conserved in bacteria - - - ko:K09939 - - - - ko00000 - - - PepSY_TM,PepSY_TM_like_2 CMS2_k127_5341419_80 1123253.AUBD01000016_gene1978 0.0004005 46.0 COG3197@1|root,COG3197@2|Bacteria 2|Bacteria P Cytochrome oxidase maturation protein ccoS - - - - - - - - - - - FixS CMS2_k127_5341419_30 631362.Thi970DRAFT_02087 1.527e-116 404.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WXM6@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase CMS2_k127_5341419_39 270374.MELB17_15167 9.4e-84 294.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,4650C@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG0348 Polyferredoxin ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C CMS2_k127_5341419_60 1232683.ADIMK_3257 1.076e-38 156.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,464W3@72275|Alteromonadaceae 1236|Gammaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - iJN746.PP_4253 Cytochrome_CBB3,FixP_N CMS2_k127_5341419_77 713587.THITH_06435 1.519e-08 59.0 COG4736@1|root,COG4736@2|Bacteria 2|Bacteria O Cbb3-type cytochrome oxidase ccoQ - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ CMS2_k127_5341419_44 1288963.ADIS_2308 9.093e-72 250.0 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,47MI5@768503|Cytophagia 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO CMS2_k127_5341419_7 1297742.A176_05050 2.961e-214 675.0 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2WM27@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404,ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO CMS2_k127_5341419_67 314345.SPV1_10249 2.354e-23 109.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria 1224|Proteobacteria P biogenesis protein braZ - - ko:K09792 - - - - ko00000 - - - DsbD_2 CMS2_k127_5341419_56 1121930.AQXG01000023_gene1633 3.598e-53 199.0 COG2234@1|root,COG2234@2|Bacteria,4NFZR@976|Bacteroidetes,1ISM5@117747|Sphingobacteriia 976|Bacteroidetes O Peptidase, M28 - - - - - - - - - - - - PD40,PDZ_2,Peptidase_M28 CMS2_k127_5341419_58 1267535.KB906767_gene4940 6.376e-45 168.0 COG2318@1|root,COG2318@2|Bacteria,3Y579@57723|Acidobacteria,2JJPN@204432|Acidobacteriia 204432|Acidobacteriia S DinB family - - - - - - - - - - - - DinB CMS2_k127_5341419_40 620914.JH621248_gene3091 2.037e-82 286.0 COG2866@1|root,COG2866@2|Bacteria,4NPSD@976|Bacteroidetes,1I880@117743|Flavobacteriia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS2_k127_5341419_54 1232410.KI421421_gene3694 2.773e-55 204.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42QU4@68525|delta/epsilon subdivisions,2WMRQ@28221|Deltaproteobacteria,43SHI@69541|Desulfuromonadales 28221|Deltaproteobacteria M Domain amino terminal to FKBP-type peptidyl-prolyl isomerase - - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N CMS2_k127_5341419_43 1121405.dsmv_3775 9.004e-74 256.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42S8R@68525|delta/epsilon subdivisions,2X5W1@28221|Deltaproteobacteria,2MK5S@213118|Desulfobacterales 28221|Deltaproteobacteria C [2Fe-2S] binding domain - - 1.3.99.16 ko:K07302,ko:K13483 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Fer2_2 CMS2_k127_5341419_1 335543.Sfum_2510 3.482e-313 977.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MR87@213462|Syntrophobacterales 28221|Deltaproteobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.17.1.4 ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2 CMS2_k127_5341419_26 706587.Desti_3923 2.994e-130 422.0 COG1319@1|root,COG1319@2|Bacteria,1MVJS@1224|Proteobacteria,42RX4@68525|delta/epsilon subdivisions,2WNBJ@28221|Deltaproteobacteria,2MQZF@213462|Syntrophobacterales 28221|Deltaproteobacteria C CO dehydrogenase flavoprotein C-terminal domain - - 1.17.1.4 ko:K11178 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5 CMS2_k127_5341419_31 1047013.AQSP01000139_gene2395 1.186e-113 400.0 COG1033@1|root,COG1033@2|Bacteria,2NQ2I@2323|unclassified Bacteria 2|Bacteria S MMPL family hpnN - - ko:K07003 - - - - ko00000 - - - MMPL CMS2_k127_5341419_9 84531.JMTZ01000036_gene450 6.56e-196 627.0 COG3525@1|root,COG3534@1|root,COG3525@2|Bacteria,COG3534@2|Bacteria,1MVDE@1224|Proteobacteria,1RMNI@1236|Gammaproteobacteria,1X9BH@135614|Xanthomonadales 135614|Xanthomonadales G Glycosyl hydrolase family 20, catalytic domain - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - CHB_HEX_C_1,Glyco_hydro_20,Glyco_hydro_20b,PA14 CMS2_k127_5341419_19 861299.J421_4340 1.017e-149 485.0 COG0520@1|root,COG0520@2|Bacteria,1ZSV8@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS2_k127_5341419_12 861299.J421_6365 4.533e-182 584.0 COG0154@1|root,COG0154@2|Bacteria,1ZT15@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Amidase - - - - - - - - - - - - Amidase CMS2_k127_5341419_14 420246.GTNG_2267 3.918e-176 563.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1WE4Y@129337|Geobacillus 91061|Bacilli C Aldehyde dehydrogenase family gabD_2 - 1.2.1.9 ko:K00131 ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200 M00308,M00633 R01058 RC00242 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS2_k127_5341419_22 566466.NOR53_1474 1.069e-137 447.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1S00K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA CMS2_k127_5341419_10 1121920.AUAU01000023_gene2400 4.758e-190 603.0 COG0471@1|root,COG0471@2|Bacteria,3Y6TC@57723|Acidobacteria 57723|Acidobacteria P Sodium:sulfate symporter transmembrane region - - - ko:K03319 - - - - ko00000 2.A.47 - - Na_sulph_symp CMS2_k127_5341419_52 287.DR97_4708 3.086e-58 213.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1RP9U@1236|Gammaproteobacteria,1YFER@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase CMS2_k127_5341419_17 234267.Acid_3470 6.398e-161 536.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5341419_20 379066.GAU_0052 3.182e-146 495.0 COG2866@1|root,COG2866@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity - - - ko:K14054 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 CMS2_k127_5341419_76 1123279.ATUS01000004_gene2817 6.444e-09 66.0 29ER0@1|root,301NT@2|Bacteria,1RE0Y@1224|Proteobacteria,1S5BS@1236|Gammaproteobacteria,1J61S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5341419_21 861299.J421_6317 1.294e-140 490.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6317|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_5341419_50 861299.J421_6160 5.877e-61 241.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6160|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_5341419_11 861299.J421_1230 7.656e-189 624.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_5341419_28 861299.J421_2830 2.703e-129 440.0 COG1629@1|root,COG4771@2|Bacteria,1ZU8C@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - Plug CMS2_k127_5341419_74 1189612.A33Q_2518 4.742e-13 77.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase,Glyoxalase_2 CMS2_k127_5341419_16 215803.DB30_1529 3.395e-164 530.0 COG2304@1|root,COG2304@2|Bacteria,1R8EZ@1224|Proteobacteria,433AE@68525|delta/epsilon subdivisions,2WYFQ@28221|Deltaproteobacteria,2YY3M@29|Myxococcales 28221|Deltaproteobacteria S IgA Peptidase M64 - - - - - - - - - - - - M64_N,Peptidase_M64 CMS2_k127_5341419_8 234267.Acid_7369 7.956e-202 645.0 COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria 57723|Acidobacteria S PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_3 CMS2_k127_5341419_47 1282360.ABAC460_22785 5.86e-64 232.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2U25R@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese CMS2_k127_5341419_65 1173263.Syn7502_00507 4.057e-31 130.0 2DC00@1|root,2ZC4V@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_5341419_35 344747.PM8797T_04345 2.344e-94 322.0 COG1446@1|root,COG1446@2|Bacteria,2IZ4V@203682|Planctomycetes 203682|Planctomycetes E PFAM peptidase T2 asparaginase 2 - - 3.4.19.5,3.5.1.26 ko:K01444,ko:K13051 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000,ko01002 - - - Asparaginase_2,DUF4440 CMS2_k127_5341419_25 1047013.AQSP01000134_gene1338 1.492e-132 440.0 COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria 2|Bacteria H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB CMS2_k127_5341419_71 1191523.MROS_2096 2.8e-17 91.0 COG1410@1|root,COG1410@2|Bacteria 2|Bacteria E methionine synthase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Met_synt_B12 CMS2_k127_5341419_49 515635.Dtur_0729 3.657e-63 223.0 COG5012@1|root,COG5012@2|Bacteria 2|Bacteria T cobalamin binding - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,URO-D CMS2_k127_5341419_42 243231.GSU2921 7.048e-78 270.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,43U7R@69541|Desulfuromonadales 28221|Deltaproteobacteria H Methionine synthase B12-binding module cap domain protein metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans CMS2_k127_5341419_69 861299.J421_6140 2.765e-20 93.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_5341419_15 251221.35211765 5.445e-171 568.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_5341419_59 945713.IALB_0020 4.299e-44 164.0 COG4747@1|root,COG4747@2|Bacteria 2|Bacteria - - hom - 1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00025,M00570 R00220,R00996,R01513,R01728,R01773,R01775 RC00031,RC00087,RC00125,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3 CMS2_k127_5341419_3 443143.GM18_0341 3.373e-284 889.0 COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - - CMS2_k127_5423671_1 204669.Acid345_0755 2.964e-37 143.0 COG1695@1|root,COG1695@2|Bacteria,3Y4XM@57723|Acidobacteria,2JJHR@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_5423671_0 1267535.KB906767_gene5108 8.276e-161 540.0 COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria,2JITF@204432|Acidobacteriia 204432|Acidobacteriia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5423671_3 1079460.ATTQ01000023_gene270 1.688e-12 75.0 COG4319@1|root,COG4319@2|Bacteria,1RF3Q@1224|Proteobacteria,2U78H@28211|Alphaproteobacteria,4BJV7@82115|Rhizobiaceae 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS2_k127_5423671_4 1224318.DT73_25690 2.424e-07 55.0 COG1961@1|root,COG1961@2|Bacteria,1MXXT@1224|Proteobacteria,1S08N@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Site-specific recombinases, DNA invertase Pin homologs pinE GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - ko:K14060 - - - - ko00000 - - - HTH_7,Resolvase CMS2_k127_5423671_5 610130.Closa_2757 6.198e-05 49.0 COG1961@1|root,COG1961@2|Bacteria,1TPBH@1239|Firmicutes,248J7@186801|Clostridia,21Y50@1506553|Lachnoclostridium 186801|Clostridia L COG COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom CMS2_k127_5423671_6 10224.XP_006818314.1 0.000133 54.0 KOG2177@1|root,KOG2177@2759|Eukaryota,38EA3@33154|Opisthokonta,3BFJH@33208|Metazoa,3CRTV@33213|Bilateria 33208|Metazoa O Tripartite motif-containing protein - - 2.3.2.27 ko:K11997,ko:K12035 ko05206,map05206 - - - ko00000,ko00001,ko01000,ko03019,ko04121 - - - DUF3583,Filamin,NHL,zf-B_box,zf-C3HC4,zf-C3HC4_3,zf-RING_UBOX CMS2_k127_5438364_3 1379270.AUXF01000002_gene1589 4.379e-36 139.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_5438364_2 1121904.ARBP01000008_gene3256 1.912e-82 293.0 COG0667@1|root,COG0667@2|Bacteria,4PPAM@976|Bacteroidetes 976|Bacteroidetes C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS2_k127_5438364_0 366602.Caul_1291 9.839e-201 646.0 COG1874@1|root,COG1874@2|Bacteria,1P0Y5@1224|Proteobacteria,2TUD3@28211|Alphaproteobacteria,2KIF9@204458|Caulobacterales 204458|Caulobacterales G Beta-galactosidase - - - - - - - - - - - - Glyco_hydro_35,Glyco_hydro_42 CMS2_k127_5438364_1 1089545.KB913037_gene221 5.197e-88 296.0 COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4E0K4@85010|Pseudonocardiales 201174|Actinobacteria G Belongs to the glycosyl hydrolase 3 family bglX - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C CMS2_k127_545632_5 234267.Acid_6481 3.787e-27 112.0 COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria 57723|Acidobacteria V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_545632_4 1279009.ADICEAN_01395 1.106e-30 129.0 COG0457@1|root,COG0457@2|Bacteria,4NQ40@976|Bacteroidetes,47XP3@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF2911) - - - - - - - - - - - - DUF2911 CMS2_k127_545632_3 379066.GAU_2937 4.903e-51 188.0 COG1999@1|root,COG2847@1|root,COG1999@2|Bacteria,COG2847@2|Bacteria 2|Bacteria P Copper chaperone PCu(A)C hyaE GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277 - ko:K03619,ko:K07152,ko:K09796 - - - - ko00000,ko03029,ko03110 - - - HyaE,PCuAC,SCO1-SenC CMS2_k127_545632_6 1569209.BBPH01000182_gene3410 6.336e-14 78.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,2PWXH@265|Paracoccus 28211|Alphaproteobacteria S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - DUF1775,PCuAC CMS2_k127_545632_2 1229780.BN381_80207 4.316e-59 216.0 COG3336@1|root,COG3336@2|Bacteria 2|Bacteria G cytochrome c oxidase ctaG - - ko:K02351,ko:K02862 - - - - ko00000 - - - Caa3_CtaG CMS2_k127_545632_7 626523.GCWU000342_00475 7.601e-10 66.0 2E6A2@1|root,330XY@2|Bacteria,1VISZ@1239|Firmicutes,24QK3@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - PqqD CMS2_k127_545632_0 880073.Calab_3693 4.411e-243 768.0 COG1297@1|root,COG1297@2|Bacteria,2NPP0@2323|unclassified Bacteria 2|Bacteria S OPT oligopeptide transporter protein oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT CMS2_k127_545632_1 1242864.D187_005224 8.783e-89 310.0 COG2843@1|root,COG2843@2|Bacteria,1Q4SV@1224|Proteobacteria,42ZT3@68525|delta/epsilon subdivisions,2WV46@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - - - - - - - - - - PGA_cap CMS2_k127_5466149_8 1519464.HY22_03915 1.161e-30 121.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity yuxL - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 CMS2_k127_5466149_13 391615.ABSJ01000002_gene467 0.0003989 50.0 2DU2E@1|root,33NN7@2|Bacteria,1P5P1@1224|Proteobacteria,1SV3F@1236|Gammaproteobacteria,1JBM0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5466149_10 861299.J421_3219 1.382e-12 75.0 COG2825@1|root,COG2825@2|Bacteria,1ZU5E@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Outer membrane protein (OmpH-like) - - - ko:K06142 - - - - ko00000 - - - OmpH CMS2_k127_5466149_5 448385.sce4697 2.047e-72 259.0 COG3021@1|root,COG3021@2|Bacteria,1NJVF@1224|Proteobacteria,43E6G@68525|delta/epsilon subdivisions,2WZV9@28221|Deltaproteobacteria,2Z2TR@29|Myxococcales 28221|Deltaproteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos CMS2_k127_5466149_7 517417.Cpar_0325 1.564e-36 150.0 COG0589@1|root,COG0589@2|Bacteria,1FF41@1090|Chlorobi 1090|Chlorobi T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp CMS2_k127_5466149_0 768671.ThimaDRAFT_4175 2.706e-251 799.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C CMS2_k127_5466149_6 1122247.C731_4053 3.546e-69 258.0 COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,233VS@1762|Mycobacteriaceae 201174|Actinobacteria E PFAM FAD dependent oxidoreductase - - - - - - - - - - - - DAO CMS2_k127_5466149_2 56110.Oscil6304_1572 1.095e-194 627.0 COG2936@1|root,COG2936@2|Bacteria 2|Bacteria V dipeptidyl-peptidase activity - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 CMS2_k127_5466149_9 1123276.KB893245_gene1401 1.097e-18 92.0 COG2866@1|root,COG2866@2|Bacteria,4NF3D@976|Bacteroidetes,47MVZ@768503|Cytophagia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS2_k127_5466149_4 555500.I215_10435 2.036e-72 261.0 COG0665@1|root,COG0665@2|Bacteria,4NEUE@976|Bacteroidetes,1HYMG@117743|Flavobacteriia 976|Bacteroidetes E Glycine D-amino acid dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO CMS2_k127_5466149_3 1047013.AQSP01000139_gene2322 5.506e-188 603.0 COG2382@1|root,COG2382@2|Bacteria 2|Bacteria P enterobactin catabolic process - - - - - - - - - - - - Esterase CMS2_k127_5466149_11 392500.Swoo_3735 1.446e-09 66.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,2QA8J@267890|Shewanellaceae 1236|Gammaproteobacteria M TonB-dependent receptor plug btuB GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696 Plug,TonB_dep_Rec CMS2_k127_5466149_1 861299.J421_4227 1.327e-249 805.0 COG1629@1|root,COG4771@2|Bacteria,1ZUM3@142182|Gemmatimonadetes 142182|Gemmatimonadetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_5502359_13 448385.sce0969 5.628e-54 213.0 COG1409@1|root,COG1409@2|Bacteria,1R0BM@1224|Proteobacteria,43CTY@68525|delta/epsilon subdivisions,2X81I@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - - - - - - - - - - - CMS2_k127_5502359_12 247490.KSU1_C1324 1.17e-59 230.0 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin CMS2_k127_5502359_28 1168289.AJKI01000011_gene504 0.0004837 53.0 COG3291@1|root,COG3291@2|Bacteria,4PHVT@976|Bacteroidetes,2FUHU@200643|Bacteroidia,3XIYY@558415|Marinilabiliaceae 976|Bacteroidetes S PKD domain - - - - - - - - - - - - CHU_C,PKD CMS2_k127_5502359_0 1000565.METUNv1_00935 6.761e-252 797.0 COG0469@1|root,COG2046@1|root,COG0469@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VR2T@28216|Betaproteobacteria,2KYGT@206389|Rhodocyclales 206389|Rhodocyclales H PUA-like domain - - - - - - - - - - - - ATP-sulfurylase,PK,PUA_2 CMS2_k127_5502359_5 1122182.KB903813_gene2669 4.237e-99 356.0 COG1409@1|root,COG1409@2|Bacteria,2IM97@201174|Actinobacteria,4D9VR@85008|Micromonosporales 201174|Actinobacteria S Calcineurin-like phosphoesterase - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Metallophos CMS2_k127_5502359_24 935866.JAER01000039_gene610 3.77e-09 70.0 COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales 201174|Actinobacteria S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - DUF5122,Laminin_G_3,Malectin,PKD CMS2_k127_5502359_6 43759.JNWK01000016_gene272 9.604e-97 349.0 COG1409@1|root,COG1409@2|Bacteria,2IM97@201174|Actinobacteria 201174|Actinobacteria S Calcineurin-like phosphoesterase - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Metallophos CMS2_k127_5502359_7 1254432.SCE1572_50660 8.812e-95 337.0 2DBEW@1|root,2Z8UY@2|Bacteria,1QZEI@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4874) - - - - - - - - - - - - DUF4832,DUF4874 CMS2_k127_5502359_9 292459.STH2712 2.398e-91 316.0 COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia 186801|Clostridia M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 CMS2_k127_5502359_8 1381123.AYOD01000008_gene3150 4.953e-93 323.0 COG0125@1|root,COG0125@2|Bacteria,1RA0K@1224|Proteobacteria,2VGKS@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis - - - - - - - - - - - - - CMS2_k127_5502359_3 1173027.Mic7113_1861 1.773e-109 366.0 COG0438@1|root,COG0438@2|Bacteria,1G27U@1117|Cyanobacteria,1H99H@1150|Oscillatoriales 1117|Cyanobacteria M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS2_k127_5502359_17 1227497.C491_18204 6.157e-28 127.0 COG0438@1|root,arCOG01411@2157|Archaea,2Y8C2@28890|Euryarchaeota,2418F@183963|Halobacteria 183963|Halobacteria M Glycosyltransferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 CMS2_k127_5502359_25 246197.MXAN_3426 1.316e-05 53.0 COG1595@1|root,COG1595@2|Bacteria,1RBM4@1224|Proteobacteria,42S7N@68525|delta/epsilon subdivisions,2X520@28221|Deltaproteobacteria,2Z004@29|Myxococcales 28221|Deltaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2 CMS2_k127_5502359_27 575564.HMPREF0014_01241 0.0002382 50.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,3NIYQ@468|Moraxellaceae 1236|Gammaproteobacteria P P-type ATPase actP - 3.6.3.54 ko:K17686,ko:K19597 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5,3.A.3.5.20 - - E1-E2_ATPase,HMA,Hydrolase CMS2_k127_5502359_21 1121405.dsmv_3661 7.057e-11 68.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2MHN2@213118|Desulfobacterales 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase CMS2_k127_5502359_14 649638.Trad_0737 1.381e-48 191.0 COG3307@1|root,COG3307@2|Bacteria,1WNB1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M O-Antigen ligase - - - - - - - - - - - - Wzy_C CMS2_k127_5502359_1 1173025.GEI7407_2186 2.997e-149 488.0 COG2244@1|root,COG2244@2|Bacteria,1G3GP@1117|Cyanobacteria,1HAX2@1150|Oscillatoriales 1117|Cyanobacteria S Membrane protein involved in the export of O-antigen and teichoic acid - - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt_3,Polysacc_synt_C CMS2_k127_5502359_18 56780.SYN_01135 1.15e-23 113.0 COG1428@1|root,COG1428@2|Bacteria 2|Bacteria F Deoxynucleoside kinase - - - - - - - - - - - - - CMS2_k127_5502359_15 472759.Nhal_2168 1.606e-38 158.0 2D326@1|root,32TE3@2|Bacteria,1N94A@1224|Proteobacteria 1224|Proteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_1,Sulfotransfer_3 CMS2_k127_5502359_2 56780.SYN_01139 5.234e-133 443.0 COG0125@1|root,COG0125@2|Bacteria,1RA0K@1224|Proteobacteria 1224|Proteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis - - - - - - - - - - - - - CMS2_k127_5502359_4 1123278.KB893388_gene5700 6.497e-105 356.0 28NTY@1|root,2ZBSE@2|Bacteria,4NNC3@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_5502359_23 290318.Cvib_0020 1.789e-09 70.0 COG0644@1|root,COG0644@2|Bacteria,1FDD2@1090|Chlorobi 1090|Chlorobi C TIGRFAM geranylgeranyl reductase - - 1.3.1.111,1.3.1.83 ko:K10960 ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110 - R02063,R08754,R08755,R08756,R11226,R11518 RC00212,RC00522,RC01823 ko00000,ko00001,ko01000 - - - FAD_binding_3 CMS2_k127_5502359_10 926569.ANT_22630 2.408e-81 291.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G6DJ@200795|Chloroflexi 200795|Chloroflexi M Bacterial sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 CMS2_k127_5502359_11 84531.JMTZ01000114_gene2013 1.543e-80 301.0 COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,1PDUK@1224|Proteobacteria,1S8QS@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3291 FOG PKD repeat - - - - - - - - - - - - PKD,PPC,Peptidase_M43 CMS2_k127_5502359_16 195250.CM001776_gene1672 1.085e-31 145.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1GAB9@1117|Cyanobacteria 1117|Cyanobacteria O calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - Peptidase_M8 CMS2_k127_5502359_26 1463934.JOCF01000035_gene2476 1.594e-05 59.0 COG3170@1|root,COG3291@1|root,COG3170@2|Bacteria,COG3291@2|Bacteria,2GKNE@201174|Actinobacteria 201174|Actinobacteria NU Collagenase - - 3.4.24.3 ko:K01387 - - - - ko00000,ko01000,ko01002,ko02042 - - - PKD,PPC,Peptidase_M9,Peptidase_M9_N CMS2_k127_5512077_18 335543.Sfum_1619 6.719e-85 293.0 COG0683@1|root,COG0683@2|Bacteria 2|Bacteria E ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 CMS2_k127_5512077_31 888059.HMPREF9071_1662 1.12e-35 153.0 28HHD@1|root,2Z7T3@2|Bacteria,4NGWB@976|Bacteroidetes,1HX8A@117743|Flavobacteriia,1ERM1@1016|Capnocytophaga 976|Bacteroidetes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF3810 CMS2_k127_5512077_38 861299.J421_1081 2.968e-16 83.0 COG2314@1|root,COG2314@2|Bacteria 2|Bacteria J TM2 domain - - - - - - - - - - - - TM2 CMS2_k127_5512077_7 1121930.AQXG01000001_gene1392 3.474e-170 546.0 COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,1IP9S@117747|Sphingobacteriia 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS2_k127_5512077_5 379066.GAU_2335 6.165e-209 663.0 COG0405@1|root,COG0405@2|Bacteria,1ZU92@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS2_k127_5512077_33 379066.GAU_0126 3.496e-20 104.0 2EY2H@1|root,33RBE@2|Bacteria,1ZTHK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5512077_35 696281.Desru_2689 1.23e-17 86.0 COG1983@1|root,COG1983@2|Bacteria 2|Bacteria KT positive regulation of macromolecule biosynthetic process - - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC CMS2_k127_5512077_14 880073.Calab_3437 2.466e-130 430.0 COG1600@1|root,COG1600@2|Bacteria,2NQCR@2323|unclassified Bacteria 2|Bacteria C Reductive dehalogenase subunit cprA - - - - - - - - - - - Dehalogenase,Fer4,Fer4_7 CMS2_k127_5512077_21 1278307.KB906975_gene1900 3.991e-77 264.0 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,1RMQ2@1236|Gammaproteobacteria,2QHSW@267894|Psychromonadaceae 1236|Gammaproteobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx CMS2_k127_5512077_26 349741.Amuc_1932 3.062e-63 231.0 COG0251@1|root,COG0251@2|Bacteria,46V5Y@74201|Verrucomicrobia,2IW47@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP CMS2_k127_5512077_36 396588.Tgr7_1942 1.415e-16 86.0 2BZ8N@1|root,33ZRX@2|Bacteria,1N1WI@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 CMS2_k127_5512077_15 1265505.ATUG01000001_gene3682 4.181e-112 373.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2WMYV@28221|Deltaproteobacteria,2MI58@213118|Desulfobacterales 28221|Deltaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport CMS2_k127_5512077_4 1121422.AUMW01000026_gene381 1.033e-209 663.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,26131@186807|Peptococcaceae 186801|Clostridia C Belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8,1.2.1.99 ko:K00130,ko:K00135,ko:K09472,ko:K22187 ko00040,ko00250,ko00260,ko00310,ko00330,ko00350,ko00650,ko00760,ko01100,ko01120,map00040,map00250,map00260,map00310,map00330,map00350,map00650,map00760,map01100,map01120 M00027,M00136,M00555 R00713,R00714,R02401,R02565,R02566,R07417,R07418,R11768 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS2_k127_5512077_23 861299.J421_4451 5.606e-66 233.0 COG0590@1|root,COG0590@2|Bacteria 2|Bacteria FJ tRNA wobble adenosine to inosine editing guaD - - - - - - - - - - - dCMP_cyt_deam_1 CMS2_k127_5512077_20 485915.Dret_1487 1.439e-77 269.0 COG1149@1|root,COG1149@2|Bacteria,1R7VQ@1224|Proteobacteria,42QBU@68525|delta/epsilon subdivisions,2WMIM@28221|Deltaproteobacteria,2MH9Y@213115|Desulfovibrionales 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 CMS2_k127_5512077_25 269800.Tfu_0542 3.991e-64 229.0 COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4EG4P@85012|Streptosporangiales 201174|Actinobacteria G Inositol monophosphatase family hisN GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,3.1.3.25 ko:K01092,ko:K05602 ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070 M00026,M00131 R01185,R01186,R01187,R03013 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P CMS2_k127_5512077_32 1094980.Mpsy_1851 2.117e-26 117.0 COG1309@1|root,arCOG02643@2157|Archaea 2157|Archaea K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N CMS2_k127_5512077_28 861299.J421_0453 2.017e-54 211.0 COG1538@1|root,COG1538@2|Bacteria,1ZUXT@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS2_k127_5512077_39 469381.Dpep_0660 1.167e-15 89.0 COG0845@1|root,COG0845@2|Bacteria,3TATY@508458|Synergistetes 508458|Synergistetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 CMS2_k127_5512077_6 880073.Calab_0505 1.654e-201 665.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran CMS2_k127_5512077_11 1049564.TevJSym_ac01750 3.098e-138 445.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1J5NQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Polyphosphate kinase 2 (PPK2) ppk2 - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 CMS2_k127_5512077_42 1379270.AUXF01000006_gene26 7.145e-06 59.0 COG0457@1|root,COG0457@2|Bacteria,1ZU0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 CMS2_k127_5512077_16 483219.LILAB_06180 4.802e-103 352.0 COG0451@1|root,COG0451@2|Bacteria,1RBSM@1224|Proteobacteria,42XUG@68525|delta/epsilon subdivisions,2WTSY@28221|Deltaproteobacteria,2YX8Q@29|Myxococcales 28221|Deltaproteobacteria GM NAD dependent epimerase/dehydratase family - - 1.3.1.45 ko:K05281 ko00943,ko01110,map00943,map01110 - R06562,R06563,R07747,R07751 RC00805 ko00000,ko00001,ko01000 - - - Epimerase CMS2_k127_5512077_34 1121448.DGI_0173 1.755e-19 93.0 2E0M7@1|root,32W6F@2|Bacteria,1NB9Z@1224|Proteobacteria,42W6T@68525|delta/epsilon subdivisions,2WSFF@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5512077_17 644282.Deba_1503 1.139e-101 343.0 COG0500@1|root,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,42M58@68525|delta/epsilon subdivisions,2WK5Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria OQ PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 CMS2_k127_5512077_30 1121405.dsmv_0235 3.381e-38 153.0 COG1102@1|root,COG1102@2|Bacteria,1R1X4@1224|Proteobacteria,43DC5@68525|delta/epsilon subdivisions,2X8I5@28221|Deltaproteobacteria,2MPI3@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 CMS2_k127_5512077_12 1047013.AQSP01000105_gene1455 6.412e-136 445.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N CMS2_k127_5512077_2 880073.Calab_2714 1.644e-256 824.0 COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,2NQKM@2323|unclassified Bacteria 2|Bacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PPDK_N,Response_reg,SpoIIE CMS2_k127_5512077_24 1519464.HY22_03120 3.599e-64 225.0 COG1335@1|root,COG1335@2|Bacteria,1FE0F@1090|Chlorobi 1090|Chlorobi Q PFAM isochorismatase hydrolase - - - - - - - - - - - - Isochorismatase CMS2_k127_5512077_0 861299.J421_0786 1.03e-300 941.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZT4G@142182|Gemmatimonadetes 142182|Gemmatimonadetes EU Dienelactone hydrolase family - - - - - - - - - - - - PD40,Peptidase_S9 CMS2_k127_5512077_29 861299.J421_0057 1.685e-42 164.0 COG0782@1|root,COG0782@2|Bacteria,1ZTPD@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcription elongation factor, N-terminal - - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N CMS2_k127_5512077_37 861299.J421_5875 1.594e-16 84.0 2F75B@1|root,33ZKU@2|Bacteria,1ZTZQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5512077_43 452637.Oter_0018 9.836e-06 55.0 COG0479@1|root,COG0479@2|Bacteria 2|Bacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family asrA - - ko:K16950 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - Fer4_22 CMS2_k127_5512077_9 713586.KB900536_gene2395 3.409e-149 477.0 COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,1S93R@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM NmrA-like family - - - - - - - - - - - - NmrA CMS2_k127_5512077_8 1379698.RBG1_1C00001G0607 3.697e-153 510.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 CMS2_k127_5512077_13 1267535.KB906767_gene3131 2.385e-130 447.0 COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria,2JI3C@204432|Acidobacteriia 204432|Acidobacteriia V FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5512077_3 1047013.AQSP01000100_gene586 2.006e-228 718.0 COG3669@1|root,COG3669@2|Bacteria 2|Bacteria G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,F5_F8_type_C CMS2_k127_5512077_19 1007103.AFHW01000160_gene3089 4.92e-84 291.0 COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,4H9PJ@91061|Bacilli,26R2G@186822|Paenibacillaceae 91061|Bacilli S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA_2 - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase CMS2_k127_5512077_22 1121459.AQXE01000011_gene2381 3.464e-71 251.0 COG1266@1|root,COG1266@2|Bacteria,1PD7P@1224|Proteobacteria,435PI@68525|delta/epsilon subdivisions,2X03C@28221|Deltaproteobacteria,2MA9B@213115|Desulfovibrionales 28221|Deltaproteobacteria S CAAX protease self-immunity - - - - - - - - - - - - Abi CMS2_k127_5512077_1 1128421.JAGA01000002_gene1973 3.102e-294 929.0 COG3250@1|root,COG3250@2|Bacteria,2NNR1@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolases family 2 manB2 - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N CMS2_k127_5512077_10 234267.Acid_3246 8.562e-143 468.0 COG0673@1|root,COG0673@2|Bacteria,3Y76D@57723|Acidobacteria 57723|Acidobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA CMS2_k127_5512077_27 861299.J421_1280 6.126e-56 211.0 COG0515@1|root,COG3629@1|root,COG0515@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 2|Bacteria T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS2_k127_5538755_5 326427.Cagg_0668 2.83e-32 131.0 COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia 200795|Chloroflexi DZ PFAM regulator of chromosome condensation, RCC1 - - - - - - - - - - - - RCC1,RCC1_2 CMS2_k127_5538755_0 1267534.KB906758_gene2265 1.383e-320 997.0 COG2936@1|root,COG2936@2|Bacteria,3Y33N@57723|Acidobacteria 57723|Acidobacteria S Hydrolase CocE NonD family - - - - - - - - - - - - PepX_C,Peptidase_S15 CMS2_k127_5538755_4 1123242.JH636435_gene1124 4.89e-62 226.0 COG3509@1|root,COG3509@2|Bacteria 2|Bacteria Q xylan catabolic process - - - ko:K03932 - - - - ko00000 - CE1 - CBM9_1 CMS2_k127_5538755_6 861299.J421_6140 4.929e-20 94.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_5538755_1 861299.J421_0410 6.497e-178 589.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5538755_7 1121875.KB907549_gene1707 4.499e-09 61.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - ANAPC3,Guanylate_cyc,HTH_18,TPR_8 CMS2_k127_5538755_3 639282.DEFDS_2021 6.133e-107 360.0 COG1373@1|root,COG1373@2|Bacteria,2GFZK@200930|Deferribacteres 200930|Deferribacteres S Domain of unknown function (DUF4143) - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 CMS2_k127_5538755_2 1283284.AZUK01000002_gene2965 1.726e-138 456.0 COG1979@1|root,COG1979@2|Bacteria,1QUBJ@1224|Proteobacteria,1RP7C@1236|Gammaproteobacteria,1Y3W6@135624|Aeromonadales 135624|Aeromonadales C alcohol dehydrogenase - - - ko:K08325 ko00640,map00640 - R02528 RC00739 ko00000,ko00001,ko01000 - - - Fe-ADH CMS2_k127_5538755_8 7719.XP_002125078.2 0.0001234 54.0 KOG0613@1|root,KOG0613@2759|Eukaryota,392CH@33154|Opisthokonta,3BKR4@33208|Metazoa,3CSGS@33213|Bilateria,486SG@7711|Chordata 33208|Metazoa T immunoglobulin-like and fibronectin type III IGFN1 GO:0003008,GO:0003012,GO:0003674,GO:0003779,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005856,GO:0005859,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007015,GO:0008092,GO:0008150,GO:0008307,GO:0009653,GO:0009987,GO:0010927,GO:0015629,GO:0016043,GO:0016459,GO:0016460,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0031032,GO:0031033,GO:0031034,GO:0031430,GO:0031672,GO:0031674,GO:0032501,GO:0032502,GO:0032989,GO:0032991,GO:0034622,GO:0042692,GO:0042805,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043292,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0044877,GO:0045214,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0051015,GO:0051146,GO:0051371,GO:0051393,GO:0055001,GO:0055002,GO:0061061,GO:0065003,GO:0070925,GO:0071688,GO:0071840,GO:0097435,GO:0097493,GO:0099080,GO:0099081,GO:0099512 - - - - - - - - - - I-set,fn3 CMS2_k127_5570778_3 702450.CUW_2599 3.732e-45 182.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF2268,Peptidase_M1 CMS2_k127_5570778_0 1408473.JHXO01000004_gene181 1.335e-140 458.0 COG4299@1|root,COG4299@2|Bacteria,4NH8T@976|Bacteroidetes 976|Bacteroidetes S COGs COG4299 conserved - - - - - - - - - - - - DUF5009 CMS2_k127_5570778_1 616991.JPOO01000003_gene2262 1.285e-100 339.0 COG2159@1|root,COG2159@2|Bacteria,4NG9U@976|Bacteroidetes,1HYFP@117743|Flavobacteriia,23GX1@178469|Arenibacter 976|Bacteroidetes S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 CMS2_k127_5570778_2 1278073.MYSTI_05720 2.167e-63 237.0 COG2234@1|root,COG2234@2|Bacteria,1MUZ7@1224|Proteobacteria 1224|Proteobacteria S Peptidase m28 - - - - - - - - - - - - PA,Peptidase_M28 CMS2_k127_5570778_4 575540.Isop_0606 2.558e-44 171.0 COG1413@1|root,COG1413@2|Bacteria,2J0ZX@203682|Planctomycetes 203682|Planctomycetes C Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 CMS2_k127_5586646_18 861299.J421_2629 2.778e-138 442.0 COG0055@1|root,COG0055@2|Bacteria,1ZSNP@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N CMS2_k127_5586646_105 379066.GAU_0717 1.181e-20 95.0 COG0355@1|root,COG0355@2|Bacteria,1ZU1K@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N CMS2_k127_5586646_116 861299.J421_2636 1.915e-07 60.0 2FAWT@1|root,3433T@2|Bacteria,1ZTS1@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5586646_60 1379270.AUXF01000004_gene3153 1.058e-63 237.0 COG1519@1|root,COG1519@2|Bacteria,1ZSXB@142182|Gemmatimonadetes 142182|Gemmatimonadetes M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N CMS2_k127_5586646_73 861299.J421_4004 8.087e-50 188.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS2_k127_5586646_97 1521187.JPIM01000018_gene450 1.463e-29 132.0 COG1651@1|root,COG1651@2|Bacteria,2G8TG@200795|Chloroflexi,375RW@32061|Chloroflexia 32061|Chloroflexia O PFAM DSBA oxidoreductase - - - - - - - - - - - - Thioredoxin_4 CMS2_k127_5586646_81 338963.Pcar_2324 2.734e-41 164.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria,43SFK@69541|Desulfuromonadales 28221|Deltaproteobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 CMS2_k127_5586646_26 314345.SPV1_02552 1.727e-119 403.0 COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria 1224|Proteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind CMS2_k127_5586646_32 861299.J421_2654 2.297e-101 342.0 COG1774@1|root,COG1774@2|Bacteria,1ZTE8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S PSP1 C-terminal conserved region - - - - - - - - - - - - PSP1 CMS2_k127_5586646_23 379066.GAU_0736 1.642e-124 406.0 COG0825@1|root,COG0825@2|Bacteria,1ZSW6@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA CMS2_k127_5586646_3 1089553.Tph_c09340 2.739e-306 977.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,42EPB@68295|Thermoanaerobacterales 186801|Clostridia L TIGRFAM DNA polymerase III, alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon CMS2_k127_5586646_34 861299.J421_2657 2.016e-95 340.0 COG5492@1|root,COG5492@2|Bacteria,1ZSW8@142182|Gemmatimonadetes 2|Bacteria N domain, Protein - - 3.2.1.4,3.4.17.14 ko:K01179,ko:K07260,ko:K13735 ko00500,ko00550,ko01100,ko01502,ko02020,ko05100,map00500,map00550,map01100,map01502,map02020,map05100 M00651 R06200,R11307,R11308 - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - GH5,GH9 - Big_1,Big_2,Glug,IAT_beta,Invasin_D3,LysM,Mfa_like_1,SLH CMS2_k127_5586646_118 379066.GAU_2753 1.533e-06 60.0 COG2067@1|root,COG2067@2|Bacteria,1ZUT4@142182|Gemmatimonadetes 142182|Gemmatimonadetes I long-chain fatty acid transport protein - - - - - - - - - - - - - CMS2_k127_5586646_40 861299.J421_2658 1.891e-85 295.0 COG4324@1|root,COG4324@2|Bacteria,1ZT8G@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative aminopeptidase - - - - - - - - - - - - Aminopep CMS2_k127_5586646_22 240015.ACP_3542 5.111e-131 432.0 COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria,2JIUW@204432|Acidobacteriia 204432|Acidobacteriia E PFAM peptidase - - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS2_k127_5586646_56 861299.J421_2661 1.234e-68 246.0 COG0321@1|root,COG0321@2|Bacteria,1ZTM1@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB CMS2_k127_5586646_11 861299.J421_2662 1.416e-180 578.0 COG1249@1|root,COG1249@2|Bacteria,1ZT95@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim CMS2_k127_5586646_21 861299.J421_2666 3.915e-131 430.0 COG0508@1|root,COG0508@2|Bacteria,1ZSYJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding CMS2_k127_5586646_14 1379270.AUXF01000004_gene3129 2.318e-162 517.0 COG0022@1|root,COG0022@2|Bacteria,1ZTA8@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C CMS2_k127_5586646_29 379066.GAU_0750 1.515e-114 377.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 142182|Gemmatimonadetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh CMS2_k127_5586646_27 861299.J421_2669 2.94e-119 391.0 COG0320@1|root,COG0320@2|Bacteria,1ZTA3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM CMS2_k127_5586646_65 1121121.KB894302_gene770 1.305e-57 216.0 COG0665@1|root,COG0665@2|Bacteria,1VTRW@1239|Firmicutes,4HD2K@91061|Bacilli,26T5Z@186822|Paenibacillaceae 91061|Bacilli E Glycine oxidase thiO GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043436,GO:0043799,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0072527,GO:0072528,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO CMS2_k127_5586646_117 379066.GAU_0752 9.226e-07 53.0 296V5@1|root,2ZU41@2|Bacteria,1ZU78@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5586646_69 861299.J421_2673 2.47e-53 197.0 COG3170@1|root,COG3170@2|Bacteria,1ZTDF@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 CMS2_k127_5586646_84 861299.J421_2674 9.74e-39 156.0 COG0463@1|root,COG0463@2|Bacteria,1ZTJE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase family 2 - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - Glycos_transf_2 CMS2_k127_5586646_114 1121939.L861_16535 1.93e-13 72.0 COG2331@1|root,COG2331@2|Bacteria,1NMRY@1224|Proteobacteria 1224|Proteobacteria S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 CMS2_k127_5586646_104 1379270.AUXF01000004_gene3124 1.023e-21 102.0 2FDPQ@1|root,345QV@2|Bacteria,1ZU3Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5586646_103 865861.AZSU01000002_gene2787 2.352e-22 102.0 2BDXR@1|root,327MY@2|Bacteria,1UT9P@1239|Firmicutes,2521B@186801|Clostridia,36S1A@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - CMS2_k127_5586646_17 1237149.C900_03836 8.347e-142 466.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity putP_2 - - ko:K03307,ko:K11928 - - - - ko00000,ko02000 2.A.21,2.A.21.2 - - SSF CMS2_k127_5586646_24 1379270.AUXF01000004_gene3121 4.662e-122 400.0 COG4608@1|root,COG4608@2|Bacteria,1ZSTB@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY CMS2_k127_5586646_28 861299.J421_2680 2.297e-115 380.0 COG0444@1|root,COG0444@2|Bacteria,1ZSWI@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY CMS2_k127_5586646_59 411464.DESPIG_01251 1.401e-67 239.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2M8HR@213115|Desulfovibrionales 28221|Deltaproteobacteria EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N CMS2_k127_5586646_49 861299.J421_2682 3.979e-77 269.0 COG0601@1|root,COG0601@2|Bacteria,1ZTP1@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS2_k127_5586646_25 861299.J421_2683 1.233e-119 404.0 COG0747@1|root,COG0747@2|Bacteria,1ZTBU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 CMS2_k127_5586646_87 861299.J421_2684 1.173e-37 156.0 COG0095@1|root,COG0095@2|Bacteria,1ZTY2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Biotin/lipoate A/B protein ligase family - - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB CMS2_k127_5586646_0 251221.35210806 0.0 1216.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria 1117|Cyanobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P CMS2_k127_5586646_74 1379270.AUXF01000004_gene3114 1.618e-49 180.0 COG0509@1|root,COG0509@2|Bacteria,1ZTWD@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H CMS2_k127_5586646_75 861299.J421_2687 3.424e-48 179.0 COG0237@1|root,COG0237@2|Bacteria,1ZTM2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE CMS2_k127_5586646_43 379066.GAU_0768 5.427e-80 272.0 COG1435@1|root,COG1435@2|Bacteria,1ZTB2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Thymidine kinase tdk - 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK CMS2_k127_5586646_102 1415779.JOMH01000001_gene2575 3.386e-24 107.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,1X7FC@135614|Xanthomonadales 135614|Xanthomonadales L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS2_k127_5586646_98 861299.J421_2689 1.844e-28 130.0 COG0513@1|root,COG0513@2|Bacteria,1ZTQP@142182|Gemmatimonadetes 142182|Gemmatimonadetes JKL DbpA RNA binding domain - - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DbpA CMS2_k127_5586646_19 518766.Rmar_2417 1.236e-134 439.0 COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,1FJRD@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EQ Peptidase family S58 - - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 CMS2_k127_5586646_55 1379270.AUXF01000004_gene3108 2.99e-69 252.0 COG0436@1|root,COG0436@2|Bacteria,1ZTMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_5586646_91 82654.Pse7367_2896 2.908e-34 144.0 COG2380@1|root,COG2380@2|Bacteria 2|Bacteria NU COGs COG2380 conserved - - - ko:K09785 - - - - ko00000 - - - NurA CMS2_k127_5586646_8 1379270.AUXF01000004_gene3104 5.902e-242 765.0 COG0433@1|root,COG0433@2|Bacteria,1ZURZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S COG0433 Predicted ATPase - - - ko:K06915 - - - - ko00000 - - - - CMS2_k127_5586646_31 861299.J421_2696 6.269e-104 351.0 COG0420@1|root,COG0420@2|Bacteria,1ZSPE@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Calcineurin-like phosphoesterase superfamily domain - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos CMS2_k127_5586646_10 861299.J421_2697 1.08e-191 626.0 COG0419@1|root,COG0419@2|Bacteria,1ZTD9@142182|Gemmatimonadetes 142182|Gemmatimonadetes L AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - SMC_N CMS2_k127_5586646_38 861299.J421_2698 4.478e-91 310.0 COG0454@1|root,COG0454@2|Bacteria,1ZSVU@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 CMS2_k127_5586646_50 861299.J421_2704 6.22e-77 264.0 COG0302@1|root,COG0302@2|Bacteria,1ZT6I@142182|Gemmatimonadetes 142182|Gemmatimonadetes H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI CMS2_k127_5586646_67 861299.J421_2705 9.589e-55 200.0 COG4221@1|root,COG4221@2|Bacteria,1ZTPW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S KR domain - - - - - - - - - - - - adh_short CMS2_k127_5586646_101 861299.J421_2706 4.322e-26 115.0 2FCPE@1|root,344SN@2|Bacteria,1ZU2F@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5586646_12 880073.Calab_3204 7.066e-170 552.0 COG1022@1|root,COG1022@2|Bacteria,2NNTM@2323|unclassified Bacteria 2|Bacteria I COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding CMS2_k127_5586646_71 861299.J421_2711 1.931e-51 190.0 COG0457@1|root,COG0457@2|Bacteria,1ZTX0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11 CMS2_k127_5586646_78 861299.J421_2712 3.853e-45 169.0 COG2236@1|root,COG2236@2|Bacteria,1ZTQ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Phosphoribosyl transferase domain - - - ko:K07101 - - - - ko00000 - - - Pribosyltran CMS2_k127_5586646_110 861299.J421_2713 7.295e-17 87.0 COG1719@1|root,COG1719@2|Bacteria,1ZU65@142182|Gemmatimonadetes 142182|Gemmatimonadetes S 4-vinyl reductase, 4VR - - - - - - - - - - - - - CMS2_k127_5586646_107 1379270.AUXF01000002_gene1820 1.769e-18 95.0 COG0745@1|root,COG2199@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1ZT7F@142182|Gemmatimonadetes 142182|Gemmatimonadetes T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg CMS2_k127_5586646_42 1123368.AUIS01000002_gene1535 1.796e-81 287.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,2NCHN@225057|Acidithiobacillales 225057|Acidithiobacillales E Aminopeptidase P, N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 CMS2_k127_5586646_77 861299.J421_2718 9.158e-46 177.0 COG0457@1|root,COG0457@2|Bacteria,1ZTR4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - - CMS2_k127_5586646_89 404589.Anae109_3642 3.036e-36 141.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42RQI@68525|delta/epsilon subdivisions,2WNEC@28221|Deltaproteobacteria,2YUZQ@29|Myxococcales 28221|Deltaproteobacteria T Belongs to the low molecular weight phosphotyrosine protein phosphatase family arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc CMS2_k127_5586646_79 861299.J421_2069 3.436e-44 164.0 COG0234@1|root,COG0234@2|Bacteria,1ZU6V@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - - - - - - - - - - Cpn10 CMS2_k127_5586646_9 1124780.ANNU01000008_gene2662 6.426e-192 629.0 COG3127@1|root,COG3127@2|Bacteria,4NF16@976|Bacteroidetes,47MB7@768503|Cytophagia 976|Bacteroidetes Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_5586646_45 1379270.AUXF01000003_gene3739 1.092e-78 271.0 COG4181@1|root,COG4181@2|Bacteria,1ZUJS@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_5586646_58 518766.Rmar_0540 2.31e-68 240.0 COG2755@1|root,COG2755@2|Bacteria,4NE58@976|Bacteroidetes,1FJCB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase family tesA - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 CMS2_k127_5586646_51 861299.J421_2983 1.2e-74 256.0 COG0179@1|root,COG0179@2|Bacteria,1ZTIG@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - FAA_hydrolase CMS2_k127_5586646_62 1340493.JNIF01000004_gene1025 5.8e-59 229.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - ko:K07004 - - - - ko00000 - - - PKD,PPC,Peptidase_M10,Peptidase_M28,SLH CMS2_k127_5586646_35 1297742.A176_05455 5.245e-95 318.0 COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,42MQN@68525|delta/epsilon subdivisions,2WRJ0@28221|Deltaproteobacteria,2YZ2C@29|Myxococcales 28221|Deltaproteobacteria K 6-O-methylguanine DNA methyltransferase, DNA binding domain - - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - DNA_binding_1,HTH_18,Methyltransf_1N CMS2_k127_5586646_63 379066.GAU_0945 4.057e-58 215.0 COG0739@1|root,COG0739@2|Bacteria 2|Bacteria M heme binding - - - - - - - - - - - - LysM,Peptidase_M23 CMS2_k127_5586646_5 243090.RB101 1.563e-268 858.0 COG1506@1|root,COG1506@2|Bacteria,2IXK8@203682|Planctomycetes 203682|Planctomycetes E Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 CMS2_k127_5586646_15 192875.XP_004347510.1 2.507e-145 490.0 COG2304@1|root,2QRPK@2759|Eukaryota,38DTU@33154|Opisthokonta 33154|Opisthokonta S Vault protein inter-alpha-trypsin domain - - - - - - - - - - - - VIT,VWA_3 CMS2_k127_5586646_111 1265507.KB899637_gene540 3.255e-16 84.0 COG0789@1|root,COG0789@2|Bacteria,1N4Q1@1224|Proteobacteria,1SEIH@1236|Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 CMS2_k127_5586646_30 1051632.TPY_1815 1.812e-111 375.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 CMS2_k127_5586646_6 243090.RB101 5.137e-267 853.0 COG1506@1|root,COG1506@2|Bacteria,2IXK8@203682|Planctomycetes 203682|Planctomycetes E Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 CMS2_k127_5586646_4 517418.Ctha_1907 4.238e-283 898.0 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 pqqL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_5586646_72 204669.Acid345_4344 1.398e-50 189.0 COG0662@1|root,COG0662@2|Bacteria,3Y5D0@57723|Acidobacteria 57723|Acidobacteria G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - CMS2_k127_5586646_33 1356852.N008_18905 9.575e-99 338.0 COG0739@1|root,COG0739@2|Bacteria,4NEBZ@976|Bacteroidetes,47JJ1@768503|Cytophagia 976|Bacteroidetes M Peptidase family M23 - - - ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23,SH3_3,SH3_4 CMS2_k127_5586646_93 525904.Tter_0400 2.57e-33 137.0 COG0613@1|root,COG0613@2|Bacteria 2|Bacteria Q PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - Glyco_trans_1_4,Glyco_transf_4,PHP,PHP_C CMS2_k127_5586646_52 1267533.KB906737_gene2000 1.249e-71 249.0 COG0020@1|root,COG0020@2|Bacteria,3Y4GH@57723|Acidobacteria,2JKFI@204432|Acidobacteriia 204432|Acidobacteriia H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids - - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf CMS2_k127_5586646_96 234267.Acid_6293 1.365e-30 124.0 COG1846@1|root,COG1846@2|Bacteria,3Y861@57723|Acidobacteria 57723|Acidobacteria K Winged helix DNA-binding domain - - - - - - - - - - - - HTH_34 CMS2_k127_5586646_94 1128421.JAGA01000001_gene2144 8.475e-32 131.0 COG3127@1|root,COG3127@2|Bacteria 2|Bacteria Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_5586646_41 518766.Rmar_1770 6.242e-84 289.0 COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,1FJR1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P ABC transporter gldA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_5586646_86 1313304.CALK_1619 1.103e-37 163.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - gldF - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux CMS2_k127_5586646_64 518766.Rmar_1768 6.24e-58 227.0 COG3225@1|root,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,1FJTM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux CMS2_k127_5586646_120 1297742.A176_00906 5.331e-05 55.0 28V7D@1|root,2ZHAI@2|Bacteria,1RA29@1224|Proteobacteria,42R9H@68525|delta/epsilon subdivisions,2WN1D@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 CMS2_k127_5586646_1 1121422.AUMW01000009_gene3340 0.0 1181.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2618A@186807|Peptococcaceae 186801|Clostridia C Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde - - 2.3.1.54,4.3.99.4 ko:K00656,ko:K20038 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like CMS2_k127_5586646_36 768706.Desor_3980 1.465e-94 319.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,261PP@186807|Peptococcaceae 186801|Clostridia C TIGRFAM glycyl-radical enzyme activating protein family csdA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4,Fer4_12,Radical_SAM CMS2_k127_5586646_46 330214.NIDE0494 2.108e-78 269.0 COG1573@1|root,COG1573@2|Bacteria 2|Bacteria L deaminated base DNA N-glycosylase activity udgB GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - DUF4130,UDG CMS2_k127_5586646_20 566466.NOR53_1757 1.076e-131 437.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,1RNIW@1236|Gammaproteobacteria,1J5FR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases cpg2_2 - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS2_k127_5586646_112 234267.Acid_4150 8.983e-16 78.0 COG0607@1|root,32YCZ@2|Bacteria,3Y5Z1@57723|Acidobacteria 57723|Acidobacteria P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 CMS2_k127_5586646_119 203275.BFO_2789 4.6e-05 54.0 COG0347@1|root,COG0347@2|Bacteria,4NSBG@976|Bacteroidetes,2FT39@200643|Bacteroidia,22YG9@171551|Porphyromonadaceae 976|Bacteroidetes E COG NOG19114 non supervised orthologous group - - - - - - - - - - - - - CMS2_k127_5586646_2 1379270.AUXF01000001_gene2734 0.0 1032.0 COG0841@1|root,COG0841@2|Bacteria,1ZUDY@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Protein export membrane protein - - - - - - - - - - - - ACR_tran CMS2_k127_5586646_95 309807.SRU_1979 8.889e-32 140.0 COG0845@1|root,COG0845@2|Bacteria,4NF23@976|Bacteroidetes,1FJUZ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Biotin-lipoyl like - - - - - - - - - - - - HlyD_D23 CMS2_k127_5586646_83 309807.SRU_1978 2.14e-39 163.0 COG1538@1|root,COG1538@2|Bacteria,4NE4S@976|Bacteroidetes,1FJVV@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS2_k127_5586646_113 443143.GM18_2299 1.891e-15 80.0 COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,42X86@68525|delta/epsilon subdivisions,2WSJA@28221|Deltaproteobacteria,43V43@69541|Desulfuromonadales 28221|Deltaproteobacteria K PFAM regulatory protein, ArsR - - - - - - - - - - - - HTH_20,HTH_5 CMS2_k127_5586646_7 868595.Desca_0006 6.978e-262 822.0 COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,260WQ@186807|Peptococcaceae 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim CMS2_k127_5586646_108 861299.J421_2729 1.948e-17 85.0 COG5512@1|root,COG5512@2|Bacteria,1ZTYN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 CMS2_k127_5586646_47 861299.J421_2731 5.144e-78 274.0 COG1195@1|root,COG1195@2|Bacteria,1ZSRU@142182|Gemmatimonadetes 142182|Gemmatimonadetes L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N CMS2_k127_5586646_85 67257.JODR01000014_gene5693 1.852e-38 151.0 COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria 201174|Actinobacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N CMS2_k127_5586646_37 1379270.AUXF01000004_gene3079 4.236e-91 308.0 COG1024@1|root,COG1024@2|Bacteria,1ZT76@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 CMS2_k127_5586646_39 1123024.AUII01000014_gene4290 3.112e-88 302.0 COG0450@1|root,COG0450@2|Bacteria,2GM74@201174|Actinobacteria,4E0A5@85010|Pseudonocardiales 201174|Actinobacteria O Redoxin lsfA - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA CMS2_k127_5586646_121 861299.J421_2429 0.0004277 49.0 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C CMS2_k127_5586646_99 720554.Clocl_2101 1.32e-26 112.0 2DZKK@1|root,32VD5@2|Bacteria,1VB28@1239|Firmicutes,251ZY@186801|Clostridia,3WPN0@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - CMS2_k127_5586646_100 1131462.DCF50_p1700 2.117e-26 117.0 COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,2632C@186807|Peptococcaceae 186801|Clostridia S CoA-binding protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 CMS2_k127_5586646_68 1379270.AUXF01000002_gene1136 2.157e-54 200.0 COG1137@1|root,COG1137@2|Bacteria 2|Bacteria S lipopolysaccharide-transporting ATPase activity - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran CMS2_k127_5586646_48 498761.HM1_3019 3.443e-77 263.0 COG0778@1|root,COG0778@2|Bacteria,1V4ZI@1239|Firmicutes,24BD0@186801|Clostridia 186801|Clostridia C nitroreductase - - - - - - - - - - - - Nitroreductase CMS2_k127_5586646_80 421072.IO89_06265 1.083e-43 166.0 COG4403@1|root,COG4403@2|Bacteria,4PKR3@976|Bacteroidetes,1I295@117743|Flavobacteriia,3HIJ4@358033|Chryseobacterium 976|Bacteroidetes V Lanthionine synthetase C family protein - - - - - - - - - - - - - CMS2_k127_5586646_66 243233.MCA0071 1.165e-56 209.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1XF04@135618|Methylococcales 135618|Methylococcales S pfam ammecr1 - - - - - - - - - - - - AMMECR1 CMS2_k127_5586646_16 335543.Sfum_0290 2.882e-145 490.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,2MSIQ@213462|Syntrophobacterales 28221|Deltaproteobacteria M Transglycosylase mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H CMS2_k127_5586646_70 596152.DesU5LDRAFT_1246 7.554e-53 190.0 COG0346@1|root,COG0346@2|Bacteria,1RJF9@1224|Proteobacteria,42TD6@68525|delta/epsilon subdivisions,2WP89@28221|Deltaproteobacteria,2MB7M@213115|Desulfovibrionales 28221|Deltaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase CMS2_k127_5586646_44 717774.Marme_3923 7.91e-80 271.0 COG4894@1|root,COG4894@2|Bacteria,1RBD5@1224|Proteobacteria,1SKB1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Scramblase - - - - - - - - - - - - Scramblase CMS2_k127_5586646_122 396588.Tgr7_2791 0.0006003 51.0 COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,1RN4J@1236|Gammaproteobacteria,1WZ1V@135613|Chromatiales 135613|Chromatiales M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 CMS2_k127_5586646_90 1267533.KB906740_gene137 3.531e-35 144.0 29Y1S@1|root,30JUQ@2|Bacteria,3Y90C@57723|Acidobacteria,2JNWN@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - CMS2_k127_5586646_61 1089552.KI911559_gene408 1.673e-61 221.0 COG3760@1|root,COG3760@2|Bacteria,1RDIG@1224|Proteobacteria,2U87T@28211|Alphaproteobacteria,2JSRQ@204441|Rhodospirillales 204441|Rhodospirillales S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit CMS2_k127_5586646_13 1535422.ND16A_0130 1.432e-169 541.0 COG5505@1|root,COG5505@2|Bacteria,1MW87@1224|Proteobacteria,1RQPZ@1236|Gammaproteobacteria,2Q5VV@267889|Colwelliaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF819) - - - - - - - - - - - - DUF819 CMS2_k127_5586646_54 1499967.BAYZ01000145_gene6200 2.121e-69 245.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 CMS2_k127_5586646_53 1047013.AQSP01000109_gene2443 3.055e-70 254.0 COG1651@1|root,COG1651@2|Bacteria 2|Bacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - - - - - - - - - - Thioredoxin_4,VKOR CMS2_k127_5586646_76 1210884.HG799465_gene12237 3.462e-47 173.0 COG0662@1|root,COG0662@2|Bacteria,2J42S@203682|Planctomycetes 203682|Planctomycetes G Cupin domain - - - - - - - - - - - - Cupin_2 CMS2_k127_5586646_115 550540.Fbal_2135 3.619e-08 60.0 2EQBK@1|root,33HXQ@2|Bacteria,1NJKS@1224|Proteobacteria,1SW7A@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5586646_57 1227497.C491_14577 1.653e-68 239.0 COG3369@1|root,arCOG03175@1|root,arCOG03174@2157|Archaea,arCOG03175@2157|Archaea,2Y1YC@28890|Euryarchaeota,23ZKU@183963|Halobacteria 183963|Halobacteria S CDGSH-type zinc finger. Function unknown. - - - - - - - - - - - - Fer4_19,zf-CDGSH CMS2_k127_5586646_82 391937.NA2_10268 9.747e-40 158.0 COG1402@1|root,COG1402@2|Bacteria,1QMFR@1224|Proteobacteria,2TSTT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Creatinine amidohydrolase - - - - - - - - - - - - Creatininase CMS2_k127_5586646_106 1117108.PAALTS15_01217 8.496e-20 91.0 2C95S@1|root,33HPC@2|Bacteria,1VJZ1@1239|Firmicutes,4I8KU@91061|Bacilli,2703Y@186822|Paenibacillaceae 91061|Bacilli S Domain of unknown function (DUF4177) - - - - - - - - - - - - DUF4177 CMS2_k127_5586646_88 1120956.JHZK01000011_gene1213 1.429e-36 148.0 COG2890@1|root,COG2890@2|Bacteria 2|Bacteria J protein-(glutamine-N5) methyltransferase activity - - - - - - - - - - - - Methyltransf_15,Methyltransf_25,NodS CMS2_k127_5586646_92 3075.A0A087SAP3 1.449e-33 136.0 COG0046@1|root,KOG1907@2759|Eukaryota,37IK9@33090|Viridiplantae,34GNK@3041|Chlorophyta 3041|Chlorophyta F CobB/CobQ-like glutamine amidotransferase domain - - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 CMS2_k127_5614289_6 693979.Bache_0412 2.346e-13 76.0 COG0793@1|root,COG0793@2|Bacteria,4NFEN@976|Bacteroidetes,2FMMP@200643|Bacteroidia,4AKWW@815|Bacteroidaceae 976|Bacteroidetes M peptidase S41 - - - - - - - - - - - - Peptidase_S41,Tricorn_C1 CMS2_k127_5614289_1 861299.J421_6371 6.432e-121 421.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6371|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_5614289_0 1168034.FH5T_02395 2.595e-202 658.0 arCOG07336@1|root,2Z8ST@2|Bacteria,4NIV5@976|Bacteroidetes,2FM95@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_5614289_2 1280947.HY30_08305 2.098e-72 251.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - AraC_binding,Cupin_2,Cupin_7 CMS2_k127_5614289_5 660470.Theba_2634 5.852e-27 128.0 COG1305@1|root,COG1305@2|Bacteria,2GC1R@200918|Thermotogae 2|Bacteria E transglutaminase domain protein - - - - - - - - - - - - TIG,Transglut_core CMS2_k127_5614289_7 351016.RAZWK3B_19301 9.974e-13 82.0 COG0308@1|root,COG0308@2|Bacteria,1PJTM@1224|Proteobacteria,2U2D3@28211|Alphaproteobacteria,2P4EU@2433|Roseobacter 28211|Alphaproteobacteria M Peptidase family M1 domain - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 CMS2_k127_5614289_8 861299.J421_4365 3.608e-07 63.0 2EY2H@1|root,33RBE@2|Bacteria,1ZTHK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5614289_3 316274.Haur_1044 8.056e-56 206.0 COG0596@1|root,COG0596@2|Bacteria,2G8UW@200795|Chloroflexi 200795|Chloroflexi S PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6 CMS2_k127_5624743_2 1267535.KB906767_gene3834 5.293e-41 159.0 COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria 57723|Acidobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5624743_0 761193.Runsl_2487 0.0 1303.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,47NMF@768503|Cytophagia 976|Bacteroidetes G Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 CMS2_k127_5624743_1 1254432.SCE1572_34120 1.03e-87 319.0 COG2234@1|root,COG2234@2|Bacteria,1R56X@1224|Proteobacteria,43823@68525|delta/epsilon subdivisions,2X3C5@28221|Deltaproteobacteria,2YVD0@29|Myxococcales 28221|Deltaproteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS2_k127_5624743_3 435591.BDI_1158 1.32e-06 56.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,2FX80@200643|Bacteroidia,2324N@171551|Porphyromonadaceae 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_5642589_14 379066.GAU_2631 1.109e-08 67.0 COG0296@1|root,COG0296@2|Bacteria,1ZUYU@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glycogen recognition site of AMP-activated protein kinase - - - - - - - - - - - - - CMS2_k127_5642589_11 1121439.dsat_2428 1.998e-23 108.0 COG0296@1|root,COG0296@2|Bacteria,1NEFK@1224|Proteobacteria,42VRH@68525|delta/epsilon subdivisions,2WRD5@28221|Deltaproteobacteria,2MC6U@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM glycoside hydrolase family 13 domain protein - - - - - - - - - - - - AMPK1_CBM CMS2_k127_5642589_9 861299.J421_4541 9.655e-37 146.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigX - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 CMS2_k127_5642589_16 1492737.FEM08_15500 6.91e-05 53.0 2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1HZN8@117743|Flavobacteriia,2NVIV@237|Flavobacterium 976|Bacteroidetes S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 CMS2_k127_5642589_0 1047013.AQSP01000092_gene315 0.0 1335.0 COG3250@1|root,COG3250@2|Bacteria,2NQEM@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolases family 2, TIM barrel domain lacZ GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0032991,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575,GO:1902494 3.2.1.23,3.2.1.31 ko:K01190,ko:K01195 ko00040,ko00052,ko00511,ko00531,ko00600,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00052,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01105,R01478,R01678,R03355,R04783,R04979,R06114,R07818,R08127,R08260,R10830 RC00049,RC00055,RC00171,RC00452,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N CMS2_k127_5642589_3 309807.SRU_2646 8.099e-276 878.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_5642589_7 309807.SRU_2647 2.453e-103 353.0 28I15@1|root,2Z85U@2|Bacteria,4NIUE@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_5642589_1 1122179.KB890419_gene24 0.0 1199.0 COG4447@1|root,COG4447@2|Bacteria,4NI14@976|Bacteroidetes 976|Bacteroidetes S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 CMS2_k127_5642589_6 1282876.BAOK01000002_gene891 1.146e-117 396.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,4BRV7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E PFAM Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 CMS2_k127_5642589_2 1248916.ANFY01000006_gene1971 0.0 1142.0 COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,2VEV5@28211|Alphaproteobacteria,2K7TR@204457|Sphingomonadales 204457|Sphingomonadales S K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - Sortilin-Vps10 CMS2_k127_5642589_5 234267.Acid_6579 3.584e-162 518.0 COG3938@1|root,COG3938@2|Bacteria,3Y6TR@57723|Acidobacteria 57723|Acidobacteria E Proline racemase - - 5.1.1.4,5.1.1.8 ko:K01777,ko:K12658 ko00330,ko01100,map00330,map01100 - R01255,R03296 RC00479 ko00000,ko00001,ko01000 - - - Pro_racemase CMS2_k127_5642589_12 861299.J421_1749 2e-16 89.0 2C30C@1|root,2ZV1M@2|Bacteria,1ZV6Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5642589_4 411154.GFO_1255 9.671e-218 710.0 COG1629@1|root,COG4771@2|Bacteria,4NI6M@976|Bacteroidetes,1IIIH@117743|Flavobacteriia 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_5642589_8 861299.J421_1823 5.097e-96 330.0 28P8D@1|root,2ZC2C@2|Bacteria,1ZUEX@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5642589_17 985255.APHJ01000024_gene1136 0.0002641 51.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,1I04A@117743|Flavobacteriia,2P76Q@244698|Gillisia 976|Bacteroidetes P TonB dependent receptor susC - - ko:K21573 - - - - ko00000,ko02000 1.B.14.6.1 - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_5676327_1 1267534.KB906754_gene3162 7.989e-36 149.0 COG0577@1|root,COG0577@2|Bacteria,3Y6DE@57723|Acidobacteria,2JM90@204432|Acidobacteriia 204432|Acidobacteriia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5676327_3 926566.Terro_0099 4.613e-16 81.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZC@57723|Acidobacteria,2JNPM@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_5676327_2 251221.35211248 3.568e-19 92.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_5676327_0 234267.Acid_0762 3.148e-81 296.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5701857_3 1502724.FF80_04151 6.593e-71 248.0 COG3142@1|root,COG3142@2|Bacteria,1MV5W@1224|Proteobacteria,2TTKM@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Participates in the control of copper homeostasis cutC - - ko:K06201 - - - - ko00000 - - - CutC CMS2_k127_5701857_6 395494.Galf_2409 2.913e-09 62.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VHN6@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 CMS2_k127_5701857_7 278957.ABEA03000033_gene939 1.129e-08 67.0 COG3387@1|root,COG3387@2|Bacteria 2|Bacteria G glucan 1,4-alpha-glucosidase activity - - - - - - - - - - - - Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C,Glyco_hydro_125 CMS2_k127_5701857_1 1379270.AUXF01000003_gene3854 1.712e-245 773.0 COG0363@1|root,COG2120@1|root,COG0363@2|Bacteria,COG2120@2|Bacteria,1ZSQV@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase - - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso,PIG-L CMS2_k127_5701857_2 760192.Halhy_5008 2.285e-188 603.0 COG1680@1|root,COG3394@1|root,COG1680@2|Bacteria,COG3394@2|Bacteria,4NEVS@976|Bacteroidetes 976|Bacteroidetes V COG1680 Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase,YdjC CMS2_k127_5701857_0 861299.J421_5647 0.0 1274.0 COG3408@1|root,COG3408@2|Bacteria 2|Bacteria G Glycogen debranching enzyme ramA - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N CMS2_k127_5701857_5 1047013.AQSP01000053_gene289 7.917e-10 63.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40 CMS2_k127_571040_6 246197.MXAN_3650 2.503e-15 78.0 COG0577@1|root,COG0577@2|Bacteria,1PIKV@1224|Proteobacteria 1224|Proteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_571040_7 234267.Acid_5438 6.935e-14 84.0 COG1462@1|root,COG1462@2|Bacteria,3Y3KF@57723|Acidobacteria 57723|Acidobacteria M Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG CMS2_k127_571040_3 903818.KI912268_gene3050 8.709e-36 139.0 COG0735@1|root,COG0735@2|Bacteria,3Y7UH@57723|Acidobacteria 57723|Acidobacteria P Ferric uptake regulator family - - - ko:K09825 - - - - ko00000,ko03000 - - - FUR CMS2_k127_571040_1 690850.Desaf_1296 2.015e-152 504.0 COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_4,PAS_9 CMS2_k127_571040_0 1047013.AQSP01000108_gene2058 4.746e-203 663.0 COG2091@1|root,COG2091@2|Bacteria,2NQGR@2323|unclassified Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_571040_2 251221.35211983 6.46e-143 491.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_571040_5 1267533.KB906734_gene4016 1.052e-22 101.0 COG1695@1|root,COG1695@2|Bacteria,3Y8CC@57723|Acidobacteria,2JP3G@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_571040_4 1379270.AUXF01000003_gene3751 3.016e-28 118.0 COG3682@1|root,COG3682@2|Bacteria,1ZU4Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R CMS2_k127_5725259_2 1379270.AUXF01000004_gene2896 2.598e-94 326.0 28P8D@1|root,33Q3E@2|Bacteria,1ZU8R@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD_RagB CMS2_k127_5725259_0 1379270.AUXF01000002_gene1134 1.977e-207 669.0 COG2091@1|root,COG2091@2|Bacteria,1ZU9H@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - CMS2_k127_5725259_3 761193.Runsl_0274 3.426e-67 242.0 28M5H@1|root,2ZAJ9@2|Bacteria,4NESS@976|Bacteroidetes,47NNA@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_5725259_1 861299.J421_1410 1.13e-148 482.0 COG0624@1|root,COG0624@2|Bacteria,1ZSYH@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M28 - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS2_k127_5725259_4 1379270.AUXF01000001_gene2088 1.88e-09 63.0 2DDI2@1|root,2ZI6I@2|Bacteria,1ZVAF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5831342_49 439235.Dalk_0098 7.656e-19 95.0 COG0500@1|root,COG2226@2|Bacteria,1R9JW@1224|Proteobacteria,42M76@68525|delta/epsilon subdivisions,2WK4P@28221|Deltaproteobacteria,2MPDX@213118|Desulfobacterales 28221|Deltaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 CMS2_k127_5831342_53 1047013.AQSP01000131_gene1844 2.068e-14 82.0 COG1238@1|root,COG1238@2|Bacteria 2|Bacteria I metal cluster binding yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - SNARE_assoc CMS2_k127_5831342_18 420246.GTNG_2400 1.641e-95 316.0 COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,1WEZT@129337|Geobacillus 91061|Bacilli C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodA GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N CMS2_k127_5831342_16 861299.J421_3622 7.098e-123 411.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1ZTDZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PAS domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 CMS2_k127_5831342_21 861299.J421_3620 7.442e-93 313.0 COG0745@1|root,COG0745@2|Bacteria,1ZT8B@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C CMS2_k127_5831342_17 379066.GAU_2012 3.31e-100 345.0 COG5002@1|root,COG5002@2|Bacteria,1ZTF2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA CMS2_k127_5831342_41 379066.GAU_2011 2.46e-35 143.0 COG0810@1|root,COG0810@2|Bacteria,1ZSVC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C CMS2_k127_5831342_20 861299.J421_3617 2.663e-94 314.0 COG0811@1|root,COG0811@2|Bacteria,1ZTH1@142182|Gemmatimonadetes 142182|Gemmatimonadetes U MotA/TolQ/ExbB proton channel family - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB CMS2_k127_5831342_42 861299.J421_3616 2.043e-31 129.0 COG0848@1|root,COG0848@2|Bacteria,1ZTTP@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD CMS2_k127_5831342_43 861299.J421_3615 3.379e-30 126.0 COG0848@1|root,COG0848@2|Bacteria,1ZTXP@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD CMS2_k127_5831342_14 379066.GAU_2003 1.205e-127 423.0 COG0591@1|root,COG0591@2|Bacteria,1ZTEB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Sodium:solute symporter family - - - - - - - - - - - - SSF CMS2_k127_5831342_39 861299.J421_3606 3.106e-38 146.0 COG0316@1|root,COG0316@2|Bacteria,1ZTT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulphur cluster biosynthesis - - - - - - - - - - - - Fe-S_biosyn CMS2_k127_5831342_23 1379270.AUXF01000003_gene3856 5.643e-91 321.0 COG1680@1|root,COG1680@2|Bacteria,1ZT58@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_5831342_15 861299.J421_3604 4.235e-123 428.0 COG1472@1|root,COG1472@2|Bacteria,1ZTD2@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glycosyl hydrolase family 3 C-terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C CMS2_k127_5831342_2 204669.Acid345_2962 8.082e-251 782.0 COG3051@1|root,COG3051@2|Bacteria 2|Bacteria C citrate CoA-transferase activity citF - 2.8.3.10 ko:K01643 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - CitF CMS2_k127_5831342_8 204669.Acid345_2963 2.826e-155 501.0 COG2301@1|root,COG3052@1|root,COG2301@2|Bacteria,COG3052@2|Bacteria,3Y8FI@57723|Acidobacteria,2JNED@204432|Acidobacteriia 204432|Acidobacteriia G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI CMS2_k127_5831342_6 204669.Acid345_2964 1.86e-193 609.0 COG0473@1|root,COG0473@2|Bacteria,3Y2VW@57723|Acidobacteria,2JIUD@204432|Acidobacteriia 57723|Acidobacteria CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS2_k127_5831342_1 204669.Acid345_2965 2.159e-280 874.0 COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity leuD - 4.2.1.33,4.2.1.35,4.2.1.36 ko:K01703,ko:K01704,ko:K01705 ko00290,ko00300,ko00660,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00966,map01100,map01110,map01120,map01130,map01210,map01230 M00030,M00432,M00433,M00535 R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C CMS2_k127_5831342_4 204669.Acid345_2966 3.941e-214 674.0 COG2079@1|root,COG2079@2|Bacteria,3Y5N1@57723|Acidobacteria,2JK64@204432|Acidobacteriia 204432|Acidobacteriia S MmgE/PrpD family - - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD CMS2_k127_5831342_27 204669.Acid345_2967 3.673e-80 272.0 COG1418@1|root,COG1418@2|Bacteria 2|Bacteria S mRNA catabolic process - - - ko:K06950,ko:K09163 - - - - ko00000 - - - HD CMS2_k127_5831342_22 1234664.AMRO01000077_gene3432 1.003e-92 319.0 COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli,1WFX8@129337|Geobacillus 91061|Bacilli S Protein of unknown function (DUF1343) ybbC - - - - - - - - - - - DUF1343 CMS2_k127_5831342_29 243230.DR_0657 3.335e-62 226.0 COG0400@1|root,COG0400@2|Bacteria 2|Bacteria S palmitoyl-(protein) hydrolase activity - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2,Esterase CMS2_k127_5831342_38 861299.J421_3602 5.03e-40 157.0 COG0558@1|root,COG0558@2|Bacteria,1ZTIP@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf CMS2_k127_5831342_5 861299.J421_3601 1.608e-199 636.0 COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 CMS2_k127_5831342_44 1394175.AWUN01000007_gene436 2.667e-29 123.0 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CZ24@85004|Bifidobacteriales 201174|Actinobacteria P E1-E2 ATPase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS CMS2_k127_5831342_3 1191523.MROS_0791 9.971e-222 715.0 COG2217@1|root,COG2217@2|Bacteria 2|Bacteria P Heavy metal translocating P-type atpase copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS CMS2_k127_5831342_46 379066.GAU_1995 4.305e-23 101.0 2FD8C@1|root,345AC@2|Bacteria,1ZTXK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5831342_55 1121378.KB899704_gene2442 4.885e-11 65.0 COG2608@1|root,COG2608@2|Bacteria,1WKNR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P Heavy metal transport detoxification protein - - - - - - - - - - - - HMA CMS2_k127_5831342_11 861299.J421_3595 9.227e-139 457.0 COG0508@1|root,COG0508@2|Bacteria,1ZT7I@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) - - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding CMS2_k127_5831342_48 861299.J421_3593 5.315e-20 96.0 2FHQX@1|root,349IG@2|Bacteria,1ZU2X@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5831342_33 379066.GAU_1990 1.122e-57 210.0 COG0613@1|root,COG0613@2|Bacteria,1ZTHM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DNA polymerase alpha chain like domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP CMS2_k127_5831342_19 279010.BL03415 2.171e-94 321.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,4HA4N@91061|Bacilli,1ZBDJ@1386|Bacillus 91061|Bacilli C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS2_k127_5831342_31 649638.Trad_0407 1.156e-58 209.0 COG0491@1|root,COG0491@2|Bacteria,1WIMP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - - - - - - - - - - Lactamase_B CMS2_k127_5831342_50 204669.Acid345_1839 5.493e-18 87.0 COG2128@1|root,COG2128@2|Bacteria,3Y8IA@57723|Acidobacteria,2JNES@204432|Acidobacteriia 204432|Acidobacteriia S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD CMS2_k127_5831342_54 293826.Amet_3687 1.454e-11 68.0 COG2128@1|root,COG2128@2|Bacteria,1VQME@1239|Firmicutes,24V56@186801|Clostridia 186801|Clostridia S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD CMS2_k127_5831342_7 861299.J421_3587 1.265e-192 611.0 COG1027@1|root,COG1027@2|Bacteria,1ZSUY@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 CMS2_k127_5831342_10 1267535.KB906767_gene1049 1.007e-143 465.0 COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia 204432|Acidobacteriia HP PFAM UBA THIF-type NAD FAD binding - - 2.7.7.80,2.8.1.11 ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF,ThiS CMS2_k127_5831342_37 379066.GAU_1981 2.122e-50 183.0 COG0691@1|root,COG0691@2|Bacteria,1ZTQN@142182|Gemmatimonadetes 142182|Gemmatimonadetes J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB CMS2_k127_5831342_30 861299.J421_3583 1.039e-60 228.0 COG0860@1|root,COG0860@2|Bacteria,1ZSUX@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 CMS2_k127_5831342_25 861299.J421_3582 6.632e-88 299.0 COG0167@1|root,COG0167@2|Bacteria,1ZT86@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh CMS2_k127_5831342_36 1118060.CAGZ01000024_gene529 3.232e-54 199.0 COG0284@1|root,COG0284@2|Bacteria,2IPX2@201174|Actinobacteria,4CV9H@84998|Coriobacteriia 84998|Coriobacteriia F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase CMS2_k127_5831342_52 379066.GAU_1977 1.31e-15 76.0 COG0257@1|root,COG0257@2|Bacteria,1ZVAA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L36 rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 CMS2_k127_5831342_35 861299.J421_3579 4.945e-55 194.0 COG0099@1|root,COG0099@2|Bacteria,1ZTNX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 CMS2_k127_5831342_32 861299.J421_3578 2.219e-58 204.0 COG0100@1|root,COG0100@2|Bacteria,1ZTMZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 CMS2_k127_5831342_24 861299.J421_3577 7.636e-91 307.0 COG0522@1|root,COG0522@2|Bacteria,1ZTGJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 CMS2_k127_5831342_12 861299.J421_3576 7.745e-134 436.0 COG0202@1|root,COG0202@2|Bacteria,1ZTEV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L CMS2_k127_5831342_40 861299.J421_3575 1.199e-36 141.0 COG0203@1|root,COG0203@2|Bacteria,1ZTPM@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 CMS2_k127_5831342_47 796940.HMPREF9628_00853 2.1e-21 96.0 COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia 186801|Clostridia J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 CMS2_k127_5831342_9 926550.CLDAP_05850 8.802e-155 494.0 COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi 200795|Chloroflexi M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd CMS2_k127_5831342_34 483219.LILAB_34470 1.63e-56 211.0 COG1089@1|root,COG1089@2|Bacteria,1QXV3@1224|Proteobacteria,4347Z@68525|delta/epsilon subdivisions,2X7I2@28221|Deltaproteobacteria,2YXC2@29|Myxococcales 28221|Deltaproteobacteria M Polysaccharide biosynthesis protein - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd CMS2_k127_5831342_0 861299.J421_3571 0.0 1555.0 COG0458@1|root,COG0458@2|Bacteria,1ZSPK@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS CMS2_k127_5831342_28 498761.HM1_2061 6.003e-64 233.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia 186801|Clostridia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C CMS2_k127_5831342_26 515635.Dtur_0577 9.981e-83 280.0 COG0110@1|root,COG0110@2|Bacteria 2|Bacteria S O-acyltransferase activity wbpD - 2.3.1.201 ko:K13018 ko00520,map00520 - R10100 RC00004,RC00166 ko00000,ko00001,ko01000,ko01005 - - - GFO_IDH_MocA,Hexapep,Hexapep_2 CMS2_k127_5831342_13 861299.J421_3570 2.658e-129 421.0 COG0399@1|root,COG0399@2|Bacteria,1ZT81@142182|Gemmatimonadetes 142182|Gemmatimonadetes M DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 CMS2_k127_5847053_13 1379270.AUXF01000002_gene1600 0.0001075 47.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_5847053_0 886293.Sinac_1156 2.518e-245 802.0 COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,2J2QS@203682|Planctomycetes 203682|Planctomycetes KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,Pkinase CMS2_k127_5847053_7 861299.J421_0442 5.717e-31 130.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_5847053_2 926550.CLDAP_34140 1.754e-114 398.0 COG2304@1|root,COG2304@2|Bacteria,2G7VX@200795|Chloroflexi 200795|Chloroflexi S VWA domain containing CoxE-like protein - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA CMS2_k127_5847053_10 861299.J421_3614 2.845e-16 88.0 2C803@1|root,33Q52@2|Bacteria,1ZTK6@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5847053_5 861299.J421_4448 2.155e-48 199.0 COG0515@1|root,COG0515@2|Bacteria,1ZTGN@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Protein kinase domain - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_5847053_6 383372.Rcas_4424 7.005e-41 171.0 COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi,375BC@32061|Chloroflexia 32061|Chloroflexia K transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_8 CMS2_k127_5847053_8 1047013.AQSP01000131_gene1844 3.582e-19 96.0 COG1238@1|root,COG1238@2|Bacteria 2|Bacteria I metal cluster binding yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - SNARE_assoc CMS2_k127_5847053_11 1382304.JNIL01000001_gene1630 1.778e-10 72.0 COG0671@1|root,COG0671@2|Bacteria,1VBSU@1239|Firmicutes,4HPN8@91061|Bacilli,279Y0@186823|Alicyclobacillaceae 91061|Bacilli I PAP2 superfamily - - - - - - - - - - - - PAP2_3 CMS2_k127_5847053_4 880073.Calab_3788 9.099e-50 191.0 COG0451@1|root,COG0451@2|Bacteria,2NPC7@2323|unclassified Bacteria 2|Bacteria GM NAD(P)H-binding JD73_00815 - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase CMS2_k127_5847053_3 1278073.MYSTI_04190 1.319e-102 347.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales 28221|Deltaproteobacteria K acetyltransferase - - - - - - - - - - - - - CMS2_k127_5847053_1 443143.GM18_2752 1.154e-144 469.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF1 - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_5847053_9 158190.SpiGrapes_0773 2.199e-16 88.0 COG0671@1|root,COG0671@2|Bacteria,2J83Z@203691|Spirochaetes 203691|Spirochaetes I PFAM PAP2 superfamily - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 CMS2_k127_5848010_2 1051632.TPY_0530 2.959e-129 426.0 COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia 186801|Clostridia L PFAM transposase, mutator - - - ko:K07493 - - - - ko00000 - - - Transposase_mut CMS2_k127_5848010_0 565045.NOR51B_1568 1.874e-183 594.0 COG0665@1|root,COG0665@2|Bacteria,1QWQF@1224|Proteobacteria,1T4RI@1236|Gammaproteobacteria 1224|Proteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 CMS2_k127_5848010_12 1499968.TCA2_0627 0.0007364 48.0 COG2318@1|root,COG2318@2|Bacteria,1VBWW@1239|Firmicutes,4HNG1@91061|Bacilli,26X9A@186822|Paenibacillaceae 91061|Bacilli S DinB superfamily - - - - - - - - - - - - DinB_2 CMS2_k127_5848010_1 448385.sce0363 5.962e-140 461.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS2_k127_5848010_4 1232437.KL662026_gene969 1.616e-46 175.0 COG2020@1|root,COG2020@2|Bacteria,1RBJE@1224|Proteobacteria,42XPQ@68525|delta/epsilon subdivisions,2WT34@28221|Deltaproteobacteria,2MMDN@213118|Desulfobacterales 28221|Deltaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT CMS2_k127_5848010_7 861299.J421_4052 3.326e-27 123.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_4052|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_5848010_9 289377.HL41_08835 5.094e-17 83.0 COG1051@1|root,COG1051@2|Bacteria,2GHWZ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX CMS2_k127_5848010_3 861299.J421_6034 1.807e-48 198.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS2_k127_5848010_10 1267535.KB906767_gene1764 2.929e-09 60.0 COG0270@1|root,COG0270@2|Bacteria,3Y5V5@57723|Acidobacteria,2JNSG@204432|Acidobacteriia 204432|Acidobacteriia L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase CMS2_k127_5848010_6 258594.RPA0350 1.218e-38 149.0 COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,2UC41@28211|Alphaproteobacteria 28211|Alphaproteobacteria L May nick specific sequences that contain T G mispairs resulting from m5C-deamination vsr - - ko:K07458 - - - - ko00000,ko01000,ko03400 - - - Vsr CMS2_k127_5848010_11 1047013.AQSP01000127_gene500 9.598e-06 50.0 2E5C1@1|root,33MIF@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_5848010_8 762376.AXYL_04648 2.513e-22 106.0 298QF@1|root,2ZVUT@2|Bacteria,1P7X8@1224|Proteobacteria,2W5HY@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5848010_5 926556.Echvi_3673 2.632e-41 162.0 arCOG10603@1|root,32SV6@2|Bacteria,4NFE9@976|Bacteroidetes,47RY3@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_5972343_0 1121930.AQXG01000015_gene1861 3.145e-112 382.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug CMS2_k127_5975678_3 1499967.BAYZ01000076_gene754 3.248e-174 556.0 COG0641@1|root,COG0641@2|Bacteria 2|Bacteria C radical SAM aslB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM CMS2_k127_5975678_10 639283.Snov_0615 2.249e-102 344.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,3F213@335928|Xanthobacteraceae 28211|Alphaproteobacteria Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH CMS2_k127_5975678_33 244447.XP_008311124.1 0.0008041 47.0 COG5640@1|root,KOG2400@1|root,KOG2400@2759|Eukaryota,KOG3627@2759|Eukaryota,38HD2@33154|Opisthokonta,3BB2C@33208|Metazoa,3CTDT@33213|Bilateria,488E4@7711|Chordata,495N4@7742|Vertebrata,49Q6V@7898|Actinopterygii 33208|Metazoa V YLP motif containing 1 YLPM1 GO:0000122,GO:0000981,GO:0000982,GO:0001078,GO:0001227,GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0008150,GO:0008157,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016604,GO:0016607,GO:0019219,GO:0019222,GO:0019899,GO:0019902,GO:0019903,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0032204,GO:0033043,GO:0033044,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051128,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0065008,GO:0070013,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K17602 - - - - ko00000,ko01009 - - - AAA_33 CMS2_k127_5975678_12 1382356.JQMP01000001_gene1247 1.795e-98 341.0 COG0028@1|root,COG0028@2|Bacteria,2GBE1@200795|Chloroflexi,27Z26@189775|Thermomicrobia 189775|Thermomicrobia EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N CMS2_k127_5975678_7 861299.J421_2170 1.865e-126 429.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_5975678_30 234267.Acid_7916 0.0001026 48.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 234267.Acid_7916|- S cAMP biosynthetic process - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_5975678_19 861299.J421_4538 3.321e-38 158.0 2C9AW@1|root,2ZVNX@2|Bacteria,1ZUAK@142182|Gemmatimonadetes 861299.J421_4538|- - - - - - - - - - - - - - - - CMS2_k127_5975678_21 861299.J421_4539 3.284e-31 131.0 28YSJ@1|root,2ZKJZ@2|Bacteria,1ZU1U@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_5975678_22 861299.J421_4420 3.655e-22 104.0 COG0296@1|root,COG0296@2|Bacteria,1ZUZV@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glycogen recognition site of AMP-activated protein kinase - - - - - - - - - - - - - CMS2_k127_5975678_15 861299.J421_4541 9.254e-60 211.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigX - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 CMS2_k127_5975678_24 1121875.KB907548_gene1518 1.586e-20 104.0 2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1HZN8@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 CMS2_k127_5975678_26 404589.Anae109_3692 1.068e-10 69.0 COG1664@1|root,COG1664@2|Bacteria,1RHS7@1224|Proteobacteria 1224|Proteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin CMS2_k127_5975678_14 861299.J421_5836 4.323e-86 316.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_5836|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_5975678_0 1191523.MROS_2210 1.473e-311 966.0 COG0365@1|root,COG0365@2|Bacteria 2|Bacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acs - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS2_k127_5975678_17 861299.J421_2921 3.223e-51 191.0 COG0681@1|root,COG0681@2|Bacteria,1ZTQ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 CMS2_k127_5975678_16 552811.Dehly_0442 1.161e-51 197.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Cytochrom_c3_2 CMS2_k127_5975678_18 207954.MED92_04914 3.794e-43 166.0 29FS0@1|root,302PP@2|Bacteria,1RE1Q@1224|Proteobacteria,1S4I9@1236|Gammaproteobacteria,1XJQY@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - CMS2_k127_5975678_2 880073.Calab_2811 5.535e-181 591.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2NPC4@2323|unclassified Bacteria 2|Bacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - iAF987.Gmet_3470 CBS,TrkA_C,Voltage_CLC CMS2_k127_5975678_4 58123.JOFJ01000027_gene2790 3.148e-152 495.0 COG0531@1|root,COG0531@2|Bacteria,2H98W@201174|Actinobacteria,4EN0D@85012|Streptosporangiales 201174|Actinobacteria E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS2_k127_5975678_11 313603.FB2170_03985 1.135e-99 336.0 COG1834@1|root,COG1834@2|Bacteria,4NGKJ@976|Bacteroidetes,1I0NU@117743|Flavobacteriia 976|Bacteroidetes E Amidinotransferase - - - - - - - - - - - - Amidinotransf CMS2_k127_5975678_32 1499967.BAYZ01000073_gene2017 0.0006369 52.0 COG1470@1|root,COG2885@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,2NPWP@2323|unclassified Bacteria 2|Bacteria M OmpA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - DUF4384,DUF4625,OmpA,PEGA CMS2_k127_5975678_20 247490.KSU1_C1649 4.522e-32 143.0 COG0265@1|root,COG1716@1|root,COG0265@2|Bacteria,COG1716@2|Bacteria,2J23K@203682|Planctomycetes 203682|Planctomycetes OT Forkhead associated domain - - - - - - - - - - - - FHA,Trypsin_2 CMS2_k127_5975678_6 234267.Acid_5857 4.065e-139 467.0 COG0243@1|root,COG0243@2|Bacteria,3Y2IU@57723|Acidobacteria 57723|Acidobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS2_k127_5975678_1 1124780.ANNU01000020_gene3300 2.047e-218 690.0 COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,47P0R@768503|Cytophagia 976|Bacteroidetes S Peptidase family M49 - - - - - - - - - - - - Peptidase_M49 CMS2_k127_5975678_9 1047013.AQSP01000097_gene1963 1.315e-115 400.0 COG2091@1|root,COG2091@2|Bacteria,2NQ9X@2323|unclassified Bacteria 2|Bacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 CMS2_k127_5975678_8 269799.Gmet_1653 1.738e-123 402.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,42PJM@68525|delta/epsilon subdivisions,2WKJN@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 CMS2_k127_5975678_25 1124780.ANNU01000019_gene1696 4.76e-12 72.0 2DS15@1|root,33E22@2|Bacteria,4NYSK@976|Bacteroidetes,47WV4@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_5975678_27 401053.AciPR4_3113 2.232e-10 65.0 COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria,2JHPX@204432|Acidobacteriia 57723|Acidobacteria O SMART band 7 protein - - - - - - - - - - - - Band_7 CMS2_k127_5975678_28 1121957.ATVL01000009_gene890 1.114e-05 53.0 COG2318@1|root,COG2318@2|Bacteria,4NNRD@976|Bacteroidetes,47PZE@768503|Cytophagia 976|Bacteroidetes S DinB family - - - - - - - - - - - - DinB CMS2_k127_5975678_23 251221.35211248 5.187e-22 107.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_5975678_5 861299.J421_1266 1.291e-144 493.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_1266|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_5975678_29 861299.J421_1760 9.202e-05 51.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_6040944_8 379066.GAU_0620 2.858e-32 131.0 COG0526@1|root,COG0526@2|Bacteria,1ZTMM@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Glutathione peroxidase - - - - - - - - - - - - AhpC-TSA CMS2_k127_6040944_3 861299.J421_2852 7.304e-107 380.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_2852|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_6040944_9 748247.AZKH_4269 1.316e-28 123.0 COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VJQ5@28216|Betaproteobacteria,2KV0G@206389|Rhodocyclales 206389|Rhodocyclales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS2_k127_6040944_5 62928.azo2486 2.854e-79 294.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1Q33X@1224|Proteobacteria,2VKF9@28216|Betaproteobacteria,2KYG2@206389|Rhodocyclales 206389|Rhodocyclales GT Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N CMS2_k127_6040944_0 861299.J421_4338 5.123e-171 562.0 COG0457@1|root,COG0457@2|Bacteria,1ZU8U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 CMS2_k127_6040944_2 861299.J421_0460 8.202e-138 455.0 COG1807@1|root,COG1807@2|Bacteria,1ZUFB@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 CMS2_k127_6040944_4 1163617.SCD_n02152 1.986e-104 345.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria 28216|Betaproteobacteria Q Methyltransferase type 11 arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 CMS2_k127_6040944_10 706587.Desti_1512 1.486e-26 114.0 COG0640@1|root,COG0640@2|Bacteria,1Q62E@1224|Proteobacteria,4329P@68525|delta/epsilon subdivisions,2WYD0@28221|Deltaproteobacteria 28221|Deltaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 CMS2_k127_6040944_7 665942.HMPREF1022_01897 4.803e-54 196.0 COG0491@1|root,COG0491@2|Bacteria,1RJ82@1224|Proteobacteria,436KY@68525|delta/epsilon subdivisions,2X180@28221|Deltaproteobacteria,2MEFK@213115|Desulfovibrionales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - - CMS2_k127_6040944_6 639030.JHVA01000001_gene1758 5.44e-60 211.0 COG2318@1|root,COG2318@2|Bacteria,3Y4HW@57723|Acidobacteria,2JJ7C@204432|Acidobacteriia 204432|Acidobacteriia S Mycothiol maleylpyruvate isomerase N-terminal domain - - - - - - - - - - - - DinB_2 CMS2_k127_6040944_1 861299.J421_2359 1.178e-140 480.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_2359|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_6040944_11 485913.Krac_5098 3.86e-19 92.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_6047133_2 518766.Rmar_1743 9.94e-113 376.0 COG1082@1|root,COG1082@2|Bacteria,4NG1K@976|Bacteroidetes 976|Bacteroidetes G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 CMS2_k127_6047133_0 1288963.ADIS_0492 1.731e-231 736.0 COG0308@1|root,COG0308@2|Bacteria,4NG5Q@976|Bacteroidetes,47JW1@768503|Cytophagia 976|Bacteroidetes E Peptidase M1, membrane alanine aminopeptidase pepN1 - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,Peptidase_M1 CMS2_k127_6047133_1 1288963.ADIS_0493 3.459e-120 402.0 COG0006@1|root,COG0006@2|Bacteria,4NG40@976|Bacteroidetes,47MAV@768503|Cytophagia 976|Bacteroidetes E Belongs to the peptidase M24B family - - - - - - - - - - - - AMP_N,Peptidase_M24 CMS2_k127_6047133_3 667014.Thein_1962 7.782e-19 89.0 arCOG07672@1|root,32Z5Y@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4258) - - - - - - - - - - - - DUF4258 CMS2_k127_6047133_5 1454004.AW11_03754 8.713e-08 57.0 2DNZI@1|root,32ZX6@2|Bacteria,1NKC7@1224|Proteobacteria,2W4U4@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM YgiT-type zinc finger domain - - - - - - - - - - - - - CMS2_k127_6047133_6 1047013.AQSP01000051_gene2579 1.096e-05 50.0 COG0399@1|root,COG0399@2|Bacteria 2|Bacteria E UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 CMS2_k127_6047133_4 1123503.KB908060_gene122 1.531e-16 87.0 COG1595@1|root,COG1595@2|Bacteria,1RD9G@1224|Proteobacteria,2U92K@28211|Alphaproteobacteria,2KGJR@204458|Caulobacterales 204458|Caulobacterales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 CMS2_k127_6056758_1 1379270.AUXF01000002_gene1600 9.267e-97 333.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_6056758_0 740709.A10D4_07875 1.262e-224 707.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,1T1KJ@1236|Gammaproteobacteria,2QFMN@267893|Idiomarinaceae 1236|Gammaproteobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N CMS2_k127_605923_3 316067.Geob_0076 9.815e-12 76.0 COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,42S40@68525|delta/epsilon subdivisions,2WNAU@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Amidohydrolase 2 - - - - - - - - - - - - Amidohydro_2 CMS2_k127_605923_1 861299.J421_3908 9.209e-48 179.0 COG1595@1|root,COG1595@2|Bacteria,1ZT3B@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_605923_6 28737.XP_006879017.1 1.51e-07 63.0 KOG0613@1|root,KOG1181@1|root,KOG4475@1|root,KOG0613@2759|Eukaryota,KOG1181@2759|Eukaryota,KOG4475@2759|Eukaryota,38BAS@33154|Opisthokonta,3B9IR@33208|Metazoa,3CRJW@33213|Bilateria,484DC@7711|Chordata,48Y8I@7742|Vertebrata,3J1H6@40674|Mammalia,353MU@311790|Afrotheria 33208|Metazoa T Titin Z TTN GO:0000070,GO:0000228,GO:0000278,GO:0000280,GO:0000793,GO:0000794,GO:0000819,GO:0001701,GO:0001756,GO:0001932,GO:0002020,GO:0002576,GO:0002791,GO:0002793,GO:0003002,GO:0003007,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003300,GO:0003674,GO:0003779,GO:0003824,GO:0004672,GO:0004674,GO:0004713,GO:0005198,GO:0005200,GO:0005488,GO:0005509,GO:0005515,GO:0005516,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005829,GO:0005856,GO:0005859,GO:0005865,GO:0006323,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006928,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007015,GO:0007049,GO:0007059,GO:0007076,GO:0007154,GO:0007165,GO:0007275,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007507,GO:0007512,GO:0007517,GO:0008015,GO:0008092,GO:0008150,GO:0008152,GO:0008307,GO:0009581,GO:0009582,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009893,GO:0009952,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010737,GO:0010927,GO:0014706,GO:0014866,GO:0014896,GO:0014897,GO:0015629,GO:0016043,GO:0016192,GO:0016301,GO:0016310,GO:0016459,GO:0016460,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0021591,GO:0022402,GO:0022607,GO:0023052,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030048,GO:0030049,GO:0030154,GO:0030239,GO:0030240,GO:0030241,GO:0030261,GO:0030506,GO:0031032,GO:0031033,GO:0031034,GO:0031323,GO:0031399,GO:0031430,GO:0031433,GO:0031672,GO:0031674,GO:0031974,GO:0031981,GO:0032268,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032991,GO:0033058,GO:0033275,GO:0034622,GO:0035051,GO:0035265,GO:0035282,GO:0035556,GO:0035994,GO:0035995,GO:0036211,GO:0036379,GO:0040007,GO:0040011,GO:0042221,GO:0042325,GO:0042692,GO:0042802,GO:0042805,GO:0043009,GO:0043056,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043292,GO:0043412,GO:0043549,GO:0043621,GO:0043933,GO:0044057,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0044877,GO:0045055,GO:0045214,GO:0045859,GO:0046872,GO:0046903,GO:0048285,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048644,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048739,GO:0048747,GO:0048769,GO:0048856,GO:0048869,GO:0050708,GO:0050714,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050982,GO:0051015,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051146,GO:0051171,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051246,GO:0051276,GO:0051338,GO:0051371,GO:0051393,GO:0051592,GO:0051606,GO:0051716,GO:0055001,GO:0055002,GO:0055003,GO:0055006,GO:0055007,GO:0055008,GO:0055013,GO:0060047,GO:0060048,GO:0060255,GO:0060322,GO:0060415,GO:0060419,GO:0060429,GO:0060537,GO:0061053,GO:0061061,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070201,GO:0070252,GO:0070925,GO:0071103,GO:0071688,GO:0071704,GO:0071840,GO:0072359,GO:0080090,GO:0090087,GO:0090257,GO:0097435,GO:0097493,GO:0098813,GO:0099080,GO:0099081,GO:0099512,GO:0140014,GO:0140096,GO:1901077,GO:1901564,GO:1901897,GO:1903047,GO:1903530,GO:1903532,GO:1904951 2.7.11.1 ko:K12567 ko05410,ko05414,map05410,map05414 - - - ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812 - - - I-set,Ig_2,Ig_3,PPAK,Pkinase,Titin_Z,fn3,ig CMS2_k127_605923_0 861299.J421_2170 3.317e-71 266.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_605923_5 1337936.IJ00_00910 1.378e-07 64.0 2EFPZ@1|root,339G0@2|Bacteria,1GCBN@1117|Cyanobacteria,1HIZK@1161|Nostocales 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS2_k127_605923_2 1192034.CAP_3791 2.7e-20 106.0 COG3858@1|root,COG3858@2|Bacteria 2|Bacteria S chitin binding - - - - - - - - - - - - Cu_amine_oxidN1,FAD_oxidored,Glyco_hydro_18,Hydrolase_2,SLH CMS2_k127_6098947_6 272134.KB731326_gene335 5.947e-25 109.0 COG3666@1|root,COG3666@2|Bacteria,1GEUC@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 CMS2_k127_6098947_8 314278.NB231_05265 9.861e-20 91.0 COG2161@1|root,COG2161@2|Bacteria,1RJZX@1224|Proteobacteria,1S6BY@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox CMS2_k127_6098947_7 1121403.AUCV01000081_gene3759 4.582e-21 96.0 COG3668@1|root,COG3668@2|Bacteria,1N5BN@1224|Proteobacteria,43BD4@68525|delta/epsilon subdivisions,2X6S1@28221|Deltaproteobacteria,2MP1M@213118|Desulfobacterales 28221|Deltaproteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin CMS2_k127_6098947_1 643867.Ftrac_2588 2.303e-55 205.0 COG1253@1|root,COG1253@2|Bacteria,4NE7C@976|Bacteroidetes,47N7R@768503|Cytophagia 976|Bacteroidetes S PFAM CBS domain - - - - - - - - - - - - CBS,DUF21 CMS2_k127_6098947_5 234267.Acid_4928 2.099e-26 116.0 29ZWG@1|root,30MXU@2|Bacteria,3Y5VK@57723|Acidobacteria 57723|Acidobacteria S DinB superfamily - - - - - - - - - - - - DinB_2 CMS2_k127_6098947_2 710696.Intca_0345 3.394e-43 165.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25 CMS2_k127_6098947_3 323261.Noc_0167 4.945e-37 141.0 COG1476@1|root,COG1476@2|Bacteria,1QWRE@1224|Proteobacteria,1T2XD@1236|Gammaproteobacteria,1X0ZS@135613|Chromatiales 135613|Chromatiales K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3 CMS2_k127_6098947_0 1121405.dsmv_3603 1.506e-117 385.0 COG2227@1|root,COG2227@2|Bacteria,1QZT3@1224|Proteobacteria,42QXG@68525|delta/epsilon subdivisions,2WMWI@28221|Deltaproteobacteria,2MJJJ@213118|Desulfobacterales 28221|Deltaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 CMS2_k127_6098947_4 1408433.JHXV01000011_gene2081 3.164e-35 145.0 arCOG07533@1|root,31XFQ@2|Bacteria,4P9XQ@976|Bacteroidetes,1ICVA@117743|Flavobacteriia,2PBXP@246874|Cryomorphaceae 976|Bacteroidetes S Domain of unknown function (DUF4386) - - - - - - - - - - - - DUF4386 CMS2_k127_6098947_9 1189620.AJXL01000106_gene3273 1.102e-09 68.0 COG3631@1|root,COG3631@2|Bacteria,4P470@976|Bacteroidetes 976|Bacteroidetes S Ketosteroid isomerase-related protein - - - - - - - - - - - - - CMS2_k127_6111314_2 1122176.KB903532_gene2524 1.723e-36 149.0 2CESB@1|root,2Z8UZ@2|Bacteria,4NJSJ@976|Bacteroidetes,1IVD7@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_6111314_0 861299.J421_1396 4.042e-78 267.0 COG0745@1|root,COG0745@2|Bacteria 861299.J421_1396|- T phosphorelay signal transduction system - - - - - - - - - - - - - CMS2_k127_6111314_1 861299.J421_1397 4.618e-58 222.0 COG0642@1|root,COG2205@2|Bacteria,1ZUX4@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA CMS2_k127_6111314_4 861299.J421_6031 2.043e-28 121.0 COG0517@1|root,COG0517@2|Bacteria,1ZV6T@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS CMS2_k127_6111314_3 768671.ThimaDRAFT_3446 2.338e-31 125.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1WWH7@135613|Chromatiales 135613|Chromatiales HJ ATP-grasp - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,RimK CMS2_k127_611148_11 1209072.ALBT01000004_gene678 4.162e-20 99.0 COG2931@1|root,COG4254@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4254@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1FGNW@10|Cellvibrio 1236|Gammaproteobacteria MQ Cadherin-like - - - - - - - - - - - - Cadherin,Cadherin_3,HemolysinCabind,PA14 CMS2_k127_611148_17 555088.DealDRAFT_2721 4.122e-08 63.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,42KR6@68298|Syntrophomonadaceae 186801|Clostridia O Belongs to the peptidase S8 family isp - 3.4.21.62 ko:K01342,ko:K13275 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Inhibitor_I9,Peptidase_S8 CMS2_k127_611148_4 1121272.KB903272_gene462 8.954e-82 282.0 COG1409@1|root,COG1409@2|Bacteria,2GIT1@201174|Actinobacteria,4DM0J@85008|Micromonosporales 201174|Actinobacteria S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos CMS2_k127_611148_19 1267535.KB906767_gene2643 1.507e-07 62.0 COG1596@1|root,COG1596@2|Bacteria,3Y51C@57723|Acidobacteria 57723|Acidobacteria M Polysaccharide biosynthesis/export protein - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB CMS2_k127_611148_9 290397.Adeh_4274 5.334e-43 181.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WN1C@28221|Deltaproteobacteria,2Z2Y2@29|Myxococcales 28221|Deltaproteobacteria D PFAM lipopolysaccharide biosynthesis protein - - - ko:K16692 - - - - ko00000,ko01000,ko01001 - - - AAA_31,GNVR,Wzz CMS2_k127_611148_14 102129.Lepto7375DRAFT_6618 1.08e-15 86.0 COG1596@1|root,COG1596@2|Bacteria,1G0AJ@1117|Cyanobacteria,1H8T2@1150|Oscillatoriales 1117|Cyanobacteria M COG1596 Periplasmic protein involved in polysaccharide export - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB CMS2_k127_611148_5 1144275.COCOR_01810 7.281e-71 250.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,42RCM@68525|delta/epsilon subdivisions,2WN89@28221|Deltaproteobacteria,2YVX5@29|Myxococcales 28221|Deltaproteobacteria K LytTr DNA-binding domain yehT - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg CMS2_k127_611148_7 382464.ABSI01000011_gene2813 1.51e-59 222.0 COG2972@1|root,COG2972@2|Bacteria,46TY3@74201|Verrucomicrobia,2IVUC@203494|Verrucomicrobiae 203494|Verrucomicrobiae T Histidine kinase - - - - - - - - - - - - His_kinase CMS2_k127_611148_16 1380354.JIAN01000008_gene3531 1.076e-09 70.0 28SI0@1|root,2ZEUB@2|Bacteria,2GNT0@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867 CMS2_k127_611148_15 935863.AWZR01000001_gene1633 1.301e-14 81.0 COG2267@1|root,COG2267@2|Bacteria,1PB1R@1224|Proteobacteria,1S6EX@1236|Gammaproteobacteria,1X3RI@135614|Xanthomonadales 135614|Xanthomonadales I Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 CMS2_k127_611148_10 592029.DDD_2811 5.106e-29 125.0 COG0596@1|root,COG0596@2|Bacteria,4NPF5@976|Bacteroidetes,1I254@117743|Flavobacteriia 976|Bacteroidetes S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 CMS2_k127_611148_8 760192.Halhy_1278 3.176e-45 178.0 COG1262@1|root,COG4886@1|root,COG5635@1|root,COG1262@2|Bacteria,COG4886@2|Bacteria,COG5635@2|Bacteria 2|Bacteria T Nacht domain - - - - - - - - - - - - FGE-sulfatase,HEAT_2,HEAT_PBS,NACHT,Trypsin_2 CMS2_k127_611148_20 452637.Oter_0018 1.232e-06 58.0 COG0479@1|root,COG0479@2|Bacteria 2|Bacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family asrA - - ko:K16950 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - Fer4_22 CMS2_k127_611148_12 234267.Acid_2195 1.145e-19 95.0 COG3279@1|root,COG3279@2|Bacteria,3Y6RT@57723|Acidobacteria 57723|Acidobacteria T Response regulator receiver - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg CMS2_k127_611148_0 251221.35211983 1.38e-160 536.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_611148_6 1047013.AQSP01000131_gene1797 9.155e-62 226.0 COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria 2|Bacteria U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS2_k127_611148_3 1121374.KB891576_gene458 9.266e-105 358.0 COG2885@1|root,COG2885@2|Bacteria,1P1AB@1224|Proteobacteria,1RMCQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family oprF - - - - - - - - - - - OmpA CMS2_k127_611148_2 880073.Calab_1322 2.522e-105 352.0 COG0330@1|root,COG0330@2|Bacteria,2NP3W@2323|unclassified Bacteria 2|Bacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 CMS2_k127_611148_1 385682.AFSL01000072_gene1300 2.5e-111 370.0 COG0330@1|root,COG0330@2|Bacteria,4NHUE@976|Bacteroidetes,2G24T@200643|Bacteroidia,3XJT5@558415|Marinilabiliaceae 976|Bacteroidetes O prohibitin homologues hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 CMS2_k127_611148_22 1347342.BN863_1030 0.0002645 47.0 COG0729@1|root,COG0729@2|Bacteria,4NEHH@976|Bacteroidetes,1HWUE@117743|Flavobacteriia 976|Bacteroidetes M Surface antigen - - - - - - - - - - - - Bac_surface_Ag CMS2_k127_611148_18 580332.Slit_0370 5.565e-08 55.0 COG2020@1|root,COG2020@2|Bacteria,1N3YJ@1224|Proteobacteria,2VT4V@28216|Betaproteobacteria 28216|Betaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT CMS2_k127_6114065_0 472759.Nhal_0216 1.449e-139 464.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales 135613|Chromatiales M Surface antigen variable number - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 CMS2_k127_6114065_2 404589.Anae109_3728 5.571e-31 135.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding - - 1.8.1.9 ko:K00384,ko:K10914,ko:K16922 ko00450,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02020,map02024,map02025,map02026,map05111 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko01002,ko03000 - - - cNMP_binding CMS2_k127_6114065_5 1392490.JHZX01000001_gene2660 5.233e-19 96.0 COG3137@1|root,COG3137@2|Bacteria,4NJH6@976|Bacteroidetes 976|Bacteroidetes M Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 CMS2_k127_6114065_3 644801.Psest_2312 6.005e-28 123.0 COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,1SBRX@1236|Gammaproteobacteria,1Z16X@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M CmpX protein cmpX - - - - - - - - - - - MS_channel,TM_helix CMS2_k127_6114065_4 1122603.ATVI01000005_gene3041 2.584e-25 116.0 COG2239@1|root,COG2239@2|Bacteria,1NNAQ@1224|Proteobacteria,1SHM4@1236|Gammaproteobacteria 1236|Gammaproteobacteria P MgtE intracellular N domain - - - - - - - - - - - - CBS,MgtE_N CMS2_k127_6114065_1 1122603.ATVI01000005_gene3040 5.311e-57 211.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N CMS2_k127_6114720_69 743722.Sph21_4307 8.581e-12 76.0 COG0383@1|root,COG0383@2|Bacteria,4NIM9@976|Bacteroidetes,1IR3M@117747|Sphingobacteriia 976|Bacteroidetes G glycoside hydrolase family 38 - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C CMS2_k127_6114720_56 344747.PM8797T_12478 4.944e-38 149.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase CMS2_k127_6114720_30 886293.Sinac_5868 1.443e-126 415.0 COG3386@1|root,COG3386@2|Bacteria,2IXZT@203682|Planctomycetes 203682|Planctomycetes G gluconolactonase - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL CMS2_k127_6114720_24 1168034.FH5T_04370 1.511e-149 484.0 COG0657@1|root,COG0657@2|Bacteria,4NKCZ@976|Bacteroidetes 976|Bacteroidetes I alpha beta - - - - - - - - - - - - Abhydrolase_3 CMS2_k127_6114720_20 1229172.JQFA01000002_gene5091 6.681e-171 547.0 COG2610@1|root,COG2610@2|Bacteria,1G4MG@1117|Cyanobacteria,1HF7X@1150|Oscillatoriales 1117|Cyanobacteria EG GntP family permease - - - ko:K06156 - - - - ko00000,ko02000 2.A.8.1.8 - - GntP_permease CMS2_k127_6114720_33 933262.AXAM01000099_gene212 5.892e-110 367.0 COG1373@1|root,COG1373@2|Bacteria,1R9U4@1224|Proteobacteria,42ZPX@68525|delta/epsilon subdivisions,2WV2B@28221|Deltaproteobacteria,2MND9@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4143) - - - - - - - - - - - - AAA_14,DUF4143 CMS2_k127_6114720_37 1122621.ATZA01000031_gene2992 3.318e-96 322.0 2BZ6M@1|root,2Z7HW@2|Bacteria,4NDZE@976|Bacteroidetes,1IQ38@117747|Sphingobacteriia 976|Bacteroidetes S Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 CMS2_k127_6114720_59 871968.DESME_05115 7.682e-32 135.0 COG2220@1|root,COG2220@2|Bacteria,1VF1I@1239|Firmicutes,24RMQ@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 CMS2_k127_6114720_32 504472.Slin_1868 3.227e-122 412.0 COG0624@1|root,COG0624@2|Bacteria,4NEA7@976|Bacteroidetes,47JSS@768503|Cytophagia 976|Bacteroidetes E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 CMS2_k127_6114720_66 452637.Oter_1881 2.137e-22 103.0 COG1680@1|root,COG4319@1|root,COG1680@2|Bacteria,COG4319@2|Bacteria,46V0A@74201|Verrucomicrobia,3K85Q@414999|Opitutae 414999|Opitutae V beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_6114720_27 573413.Spirs_3218 1.663e-131 441.0 COG2103@1|root,COG2103@2|Bacteria 2|Bacteria G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate - - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - - CMS2_k127_6114720_63 187272.Mlg_1738 1.645e-26 117.0 COG0704@1|root,COG0704@2|Bacteria,1NRGK@1224|Proteobacteria,1SMQP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PhoU domain - - - - - - - - - - - - PhoU CMS2_k127_6114720_43 1121434.AULY01000007_gene1562 1.623e-76 276.0 COG1283@1|root,COG1283@2|Bacteria,1MXWU@1224|Proteobacteria 1224|Proteobacteria P phosphate symporter nptA - - ko:K14683 - - - - ko00000,ko02000,ko04147 2.A.58.1 - - Na_Pi_cotrans CMS2_k127_6114720_9 234267.Acid_5004 3.272e-255 818.0 COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria 57723|Acidobacteria E Peptidase M14, carboxypeptidase A - - - - - - - - - - - - Peptidase_M14 CMS2_k127_6114720_72 224914.BMEI0829 3.192e-05 55.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,1J2Q3@118882|Brucellaceae 28211|Alphaproteobacteria M Peptidase family M50 rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Peptidase_M50 CMS2_k127_6114720_3 234267.Acid_0469 0.0 1014.0 COG1506@1|root,COG1506@2|Bacteria,3Y3DT@57723|Acidobacteria 57723|Acidobacteria E peptidase S9B dipeptidylpeptidase IV domain protein - - - - - - - - - - - - DPPIV_N,Peptidase_S9 CMS2_k127_6114720_53 1122603.ATVI01000005_gene3502 2.985e-48 198.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 CMS2_k127_6114720_55 861299.J421_6034 3.848e-38 166.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS2_k127_6114720_38 161156.JQKW01000008_gene544 1.309e-88 306.0 COG3203@1|root,COG3203@2|Bacteria,2GI8G@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - CMS2_k127_6114720_31 251221.35214577 5.452e-126 426.0 COG0249@1|root,COG0249@2|Bacteria 2|Bacteria L mismatched DNA binding mutS1 - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_III,MutS_V CMS2_k127_6114720_34 886293.Sinac_3509 5.044e-108 375.0 COG3119@1|root,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes 203682|Planctomycetes P arylsulfatase A - - - - - - - - - - - - Sulfatase,TPR_16,TPR_19,TPR_2 CMS2_k127_6114720_12 1047013.AQSP01000106_gene1767 3.091e-208 661.0 COG2978@1|root,COG2978@2|Bacteria,2NQSX@2323|unclassified Bacteria 2|Bacteria H AbgT putative transporter family ydaH - - ko:K12942 - - - - ko00000 - - - ABG_transport CMS2_k127_6114720_16 1047013.AQSP01000106_gene1768 7.025e-182 603.0 COG0405@1|root,COG0405@2|Bacteria,2NP8H@2323|unclassified Bacteria 2|Bacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept CMS2_k127_6114720_2 861299.J421_1753 0.0 1125.0 COG0446@1|root,COG4888@1|root,COG0446@2|Bacteria,COG4888@2|Bacteria 2|Bacteria G ASPIC UnbV domain protein - - - - - - - - - - - - FG-GAP,Pyr_redox_2,UnbV_ASPIC,VCBS CMS2_k127_6114720_49 1123276.KB893312_gene3006 6.601e-62 231.0 28M5H@1|root,2ZAJ9@2|Bacteria,4NESS@976|Bacteroidetes,47NNA@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_6114720_11 861299.J421_1219 6.533e-223 732.0 COG4206@1|root,COG4206@2|Bacteria,1ZTBA@142182|Gemmatimonadetes 142182|Gemmatimonadetes H CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_6114720_46 1121104.AQXH01000009_gene2240 4.774e-67 251.0 28PJE@1|root,2ZC90@2|Bacteria,4NJ5D@976|Bacteroidetes,1IX2U@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - SusD_RagB CMS2_k127_6114720_71 269796.Rru_A1478 9.837e-06 57.0 COG1493@1|root,COG1493@2|Bacteria,1RE0J@1224|Proteobacteria,2U8MR@28211|Alphaproteobacteria,2JTCE@204441|Rhodospirillales 204441|Rhodospirillales T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - - - - - - - - - - - CMS2_k127_6114720_64 395961.Cyan7425_1024 4.693e-25 119.0 COG4076@1|root,COG4076@2|Bacteria,1G4RK@1117|Cyanobacteria 1117|Cyanobacteria J PRMT5 arginine-N-methyltransferase - - 2.1.1.319 ko:K11434 ko04068,ko04922,map04068,map04922 - R11216,R11217,R11219 RC00003,RC02120,RC03388,RC03390 ko00000,ko00001,ko01000,ko03036 - - - PRMT5_C,PrmA CMS2_k127_6114720_68 379066.GAU_2229 4.355e-12 72.0 2960H@1|root,2ZTB5@2|Bacteria,1ZU7H@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_6114720_41 338963.Pcar_2042 1.622e-81 291.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,43S23@69541|Desulfuromonadales 28221|Deltaproteobacteria M Lytic transglycosylase catalytic mltD2 - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT CMS2_k127_6114720_57 379066.GAU_2227 6.985e-35 142.0 COG0741@1|root,COG0741@2|Bacteria,1ZTV6@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transglycosylase SLT domain - - - - - - - - - - - - SLT CMS2_k127_6114720_52 861299.J421_3798 7.068e-49 179.0 COG0315@1|root,COG0315@2|Bacteria,1ZU6G@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC CMS2_k127_6114720_50 861299.J421_3797 7.016e-58 216.0 COG0470@1|root,COG0470@2|Bacteria,1ZT21@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 CMS2_k127_6114720_19 861299.J421_4478 5.495e-171 554.0 COG1574@1|root,COG1574@2|Bacteria,1ZU9S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 CMS2_k127_6114720_25 1047013.AQSP01000142_gene242 4.533e-139 468.0 COG2511@1|root,COG2511@2|Bacteria 2|Bacteria J GatB/GatE catalytic domain - - - - - - - - - - - - GatB_N CMS2_k127_6114720_13 1499683.CCFF01000013_gene324 1.69e-202 641.0 COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,36EB6@31979|Clostridiaceae 186801|Clostridia EJ L-asparaginase - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase CMS2_k127_6114720_40 1105029.HMPREF1137_0164 1.349e-82 292.0 COG0174@1|root,COG0174@2|Bacteria,2HRX4@201174|Actinobacteria,4D4NY@85005|Actinomycetales 201174|Actinobacteria E Glutamate--ammonia ligase, catalytic domain protein - - - - - - - - - - - - Gln-synt_C,Gln-synt_N CMS2_k127_6114720_22 292459.STH2842 4.759e-158 531.0 COG3033@1|root,COG3033@2|Bacteria,1TRGV@1239|Firmicutes,248WC@186801|Clostridia 186801|Clostridia E Beta-eliminating lyase tpl - 4.1.99.2 ko:K01668 ko00350,map00350 - R00728 RC00355,RC00364 ko00000,ko00001,ko01000 - - - Beta_elim_lyase CMS2_k127_6114720_45 1095769.CAHF01000023_gene536 4.032e-70 251.0 COG3616@1|root,COG3616@2|Bacteria,1N2SF@1224|Proteobacteria,2VJ58@28216|Betaproteobacteria,4756G@75682|Oxalobacteraceae 28216|Betaproteobacteria E Putative serine dehydratase domain - - 4.3.1.27 ko:K20757 - - - - ko00000,ko01000 - - - Ala_racemase_N,D-ser_dehydrat CMS2_k127_6114720_17 483219.LILAB_10280 2.23e-174 558.0 COG0006@1|root,COG0006@2|Bacteria,1MVHD@1224|Proteobacteria 1224|Proteobacteria E Xaa-Pro aminopeptidase - - - - - - - - - - - - Peptidase_M24 CMS2_k127_6114720_18 448385.sce2299 8.043e-172 552.0 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YWKI@29|Myxococcales 28221|Deltaproteobacteria H Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC CMS2_k127_6114720_61 1219084.AP014508_gene341 1.596e-29 123.0 COG0071@1|root,COG0071@2|Bacteria,2GDCG@200918|Thermotogae 200918|Thermotogae O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS2_k127_6114720_8 886379.AEWI01000018_gene1315 8.955e-260 824.0 COG1554@1|root,COG1554@2|Bacteria,4NFG1@976|Bacteroidetes,2FME6@200643|Bacteroidia,3XJ8I@558415|Marinilabiliaceae 976|Bacteroidetes G Glycosyl hydrolase family 65, C-terminal domain - - - - - - - - - - - - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m CMS2_k127_6114720_21 1088721.NSU_3018 1.581e-163 531.0 COG0637@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VFA5@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose - - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Trehalose_PPase CMS2_k127_6114720_23 667014.Thein_0592 1.125e-154 517.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,2GH2W@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Trehalose-phosphatase - - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase CMS2_k127_6114720_26 330214.NIDE1254 1.231e-136 460.0 COG1640@1|root,COG1640@2|Bacteria,3J106@40117|Nitrospirae 40117|Nitrospirae G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 CMS2_k127_6114720_6 1380390.JIAT01000009_gene545 9.781e-274 861.0 COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4CP7U@84995|Rubrobacteria 84995|Rubrobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 CMS2_k127_6114720_4 861299.J421_2243 0.0 1006.0 COG1523@1|root,COG1523@2|Bacteria,1ZV42@142182|Gemmatimonadetes 2|Bacteria G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) glgX - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 CMS2_k127_6114720_0 1173027.Mic7113_3738 0.0 1375.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1G2UN@1117|Cyanobacteria,1H977@1150|Oscillatoriales 1117|Cyanobacteria G Alpha amylase, catalytic domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C CMS2_k127_6114720_7 861299.J421_3816 9.695e-262 823.0 COG0366@1|root,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 CMS2_k127_6114720_5 1379270.AUXF01000005_gene635 2.81e-289 905.0 COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase CMS2_k127_6114720_28 1254432.SCE1572_02795 7.525e-130 432.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS2_k127_6114720_15 1121930.AQXG01000002_gene2362 7.307e-184 586.0 2DBJC@1|root,2Z9K5@2|Bacteria,4P1C2@976|Bacteroidetes,1IWD2@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolase family 47 - - - - - - - - - - - - Glyco_hydro_47 CMS2_k127_6114720_36 1237149.C900_03643 1.938e-105 350.0 COG0668@1|root,COG0668@2|Bacteria,4NFHD@976|Bacteroidetes,47PJS@768503|Cytophagia 976|Bacteroidetes M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel CMS2_k127_6114720_51 314230.DSM3645_15530 2.44e-57 205.0 COG4843@1|root,COG4843@2|Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 CMS2_k127_6114720_39 756272.Plabr_2883 4.27e-86 301.0 COG0515@1|root,COG0515@2|Bacteria,2J2D5@203682|Planctomycetes 203682|Planctomycetes KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_6114720_54 1232437.KL662050_gene5336 7.699e-39 155.0 COG2204@1|root,COG2204@2|Bacteria,1RJB4@1224|Proteobacteria,42T3C@68525|delta/epsilon subdivisions,2WPR5@28221|Deltaproteobacteria,2MKB3@213118|Desulfobacterales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS2_k127_6114720_10 96561.Dole_1347 7.246e-233 739.0 COG0471@1|root,COG2204@1|root,COG0471@2|Bacteria,COG2204@2|Bacteria,1MUSA@1224|Proteobacteria,42QBN@68525|delta/epsilon subdivisions,2WK9R@28221|Deltaproteobacteria,2MJF9@213118|Desulfobacterales 28221|Deltaproteobacteria P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - Na_sulph_symp CMS2_k127_6114720_65 706587.Desti_4353 1.094e-24 110.0 COG0517@1|root,COG0517@2|Bacteria,1RKZ2@1224|Proteobacteria,42SYQ@68525|delta/epsilon subdivisions,2WP9E@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM CBS domain - - - - - - - - - - - - CBS CMS2_k127_6114720_35 96561.Dole_1344 1.009e-107 370.0 COG4191@1|root,COG4191@2|Bacteria,1R9T9@1224|Proteobacteria,42PPQ@68525|delta/epsilon subdivisions,2WKI9@28221|Deltaproteobacteria,2MJ5A@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 CMS2_k127_6114720_29 344747.PM8797T_25371 5.103e-127 425.0 COG0475@1|root,COG0475@2|Bacteria,2J51D@203682|Planctomycetes 203682|Planctomycetes P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N CMS2_k127_6114720_47 395961.Cyan7425_4809 6.735e-67 237.0 COG2199@1|root,COG3706@2|Bacteria,1G5BB@1117|Cyanobacteria,3KGBC@43988|Cyanothece 1117|Cyanobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF CMS2_k127_6114720_1 1047013.AQSP01000120_gene936 0.0 1153.0 COG4354@1|root,COG4354@2|Bacteria,2NQ9B@2323|unclassified Bacteria 2|Bacteria G beta-glucosidase 2, glycosyl-hydrolase family 116 N-term - - - - - - - - - - - - DUF608,Glyco_hydr_116N CMS2_k127_6114720_67 452637.Oter_4563 2.391e-12 71.0 COG0673@1|root,COG0673@2|Bacteria,46U3Z@74201|Verrucomicrobia,3K76B@414999|Opitutae 414999|Opitutae S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C CMS2_k127_6114720_42 761193.Runsl_2608 3.953e-77 266.0 COG0363@1|root,COG0363@2|Bacteria,4NFCM@976|Bacteroidetes,47PHR@768503|Cytophagia 976|Bacteroidetes G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase - - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso CMS2_k127_6114720_48 1121346.KB899813_gene2173 1.15e-64 234.0 COG1820@1|root,COG1820@2|Bacteria,1UXPG@1239|Firmicutes,4HC0A@91061|Bacilli,26TCN@186822|Paenibacillaceae 91061|Bacilli G Belongs to the metallo-dependent hydrolases superfamily. NagA family - - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 CMS2_k127_6114720_58 382464.ABSI01000010_gene3488 5.818e-32 129.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS2_k127_6114720_14 649638.Trad_2672 8.067e-186 610.0 COG0475@1|root,COG0589@1|root,COG1762@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,COG1762@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system napA - 2.1.1.163,2.1.1.201,2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K03183 ko00051,ko00130,ko01100,ko01110,ko01120,ko02060,map00051,map00130,map01100,map01110,map01120,map02060 M00116,M00117,M00273 R03232,R04990,R04993,R06859,R08774,R09736 RC00003,RC00017,RC01253,RC01662,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - Na_H_Exchanger,Usp CMS2_k127_6114720_44 1122603.ATVI01000005_gene3040 1.548e-70 243.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N CMS2_k127_6164184_3 595537.Varpa_4433 2.441e-09 58.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2VP05@28216|Betaproteobacteria,4ADPM@80864|Comamonadaceae 28216|Betaproteobacteria L transposase IS116 IS110 IS902 family protein - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 CMS2_k127_6164184_2 1297742.A176_07575 4.651e-31 125.0 COG4034@1|root,COG4034@2|Bacteria,1RCEU@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF1152) - - - - - - - - - - - - DUF1152 CMS2_k127_6164184_0 1192124.LIG30_1791 8.429e-176 560.0 COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae 28216|Betaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 CMS2_k127_6164184_1 1237149.C900_05924 2.259e-43 171.0 COG0823@1|root,COG0823@2|Bacteria,4NIV7@976|Bacteroidetes,47RCS@768503|Cytophagia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_6189223_6 1122981.AUME01000003_gene1984 0.0001407 48.0 COG0811@1|root,COG0811@2|Bacteria,4NEA2@976|Bacteroidetes,2FMMQ@200643|Bacteroidia 976|Bacteroidetes U MotA TolQ ExbB proton channel family protein exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB CMS2_k127_6189223_5 325777.GW15_0204610 1.917e-15 77.0 COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,1SAUG@1236|Gammaproteobacteria,1X780@135614|Xanthomonadales 135614|Xanthomonadales L Transposase - - - - - - - - - - - - HTH_Tnp_1 CMS2_k127_6189223_4 706587.Desti_3351 8.387e-82 278.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,42SPM@68525|delta/epsilon subdivisions,2WMYY@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TIGRFAM channel protein, hemolysin III family - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII CMS2_k127_6189223_1 1123386.AUIW01000002_gene1282 1.215e-121 398.0 COG4864@1|root,COG4864@2|Bacteria,1WI32@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S UPF0365 protein - - - - - - - - - - - - YdfA_immunity CMS2_k127_6189223_0 1379270.AUXF01000002_gene1345 1.166e-229 744.0 COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_6189223_3 1079460.ATTQ01000033_gene4046 8.548e-92 317.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,4B8PG@82115|Rhizobiaceae 28211|Alphaproteobacteria V Beta-lactamase MA20_00470 - - - - - - - - - - - Beta-lactamase CMS2_k127_6189223_2 861299.J421_5846 4.951e-103 364.0 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS2_k127_6201804_9 861299.J421_4514 3.414e-137 449.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - BetaGal_dom4_5,Glyco_hydro_2_N,SASA CMS2_k127_6201804_4 1185876.BN8_02140 1.434e-220 699.0 COG0823@1|root,COG0823@2|Bacteria,4NG4S@976|Bacteroidetes,47KMG@768503|Cytophagia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_6201804_13 1198114.AciX9_1771 7.043e-08 56.0 2C5I9@1|root,33FY2@2|Bacteria,3Y5UQ@57723|Acidobacteria,2JK5B@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - CMS2_k127_6201804_2 1191523.MROS_0470 4.279e-248 776.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS2_k127_6201804_10 448385.sce0363 6.475e-104 357.0 COG0515@1|root,COG0515@2|Bacteria,1P913@1224|Proteobacteria,4377Q@68525|delta/epsilon subdivisions,2X28Z@28221|Deltaproteobacteria,2YUDY@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - Pkinase CMS2_k127_6201804_6 28229.ND2E_2597 1.446e-200 638.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,2Q7XA@267889|Colwelliaceae 1236|Gammaproteobacteria G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 CMS2_k127_6201804_0 203122.Sde_1318 0.0 1373.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,465S2@72275|Alteromonadaceae 1236|Gammaproteobacteria G Cellobiose phosphorylase ndvB - 2.4.1.20,2.4.1.321 ko:K00702,ko:K13688,ko:K18786 ko00500,ko01100,map00500,map01100 - R00952,R10832 RC00049,RC00397 ko00000,ko00001,ko01000,ko01003 - GH94,GT36,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase CMS2_k127_6201804_11 861299.J421_1035 3.681e-81 282.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS2_k127_6201804_1 382464.ABSI01000010_gene3859 2.181e-317 993.0 COG1472@1|root,COG1472@2|Bacteria,46TQE@74201|Verrucomicrobia 74201|Verrucomicrobia M Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C CMS2_k127_6201804_3 518766.Rmar_0690 1.17e-229 732.0 COG1457@1|root,COG1457@2|Bacteria,4NHHC@976|Bacteroidetes 976|Bacteroidetes F Belongs to the purine-cytosine permease (2.A.39) family - - - - - - - - - - - - - CMS2_k127_6201804_12 1288963.ADIS_1053 3.616e-09 68.0 2EN3D@1|root,33FRH@2|Bacteria,4NZ77@976|Bacteroidetes,47T85@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_6201804_7 518766.Rmar_0692 2.291e-179 574.0 COG4952@1|root,COG4952@2|Bacteria,4NFWW@976|Bacteroidetes 976|Bacteroidetes M sugar isomerase - - 5.3.1.14 ko:K01820 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01906,R02437,R06589 RC00376,RC00434,RC00516 ko00000,ko00001,ko01000 - - - - CMS2_k127_6201804_8 518766.Rmar_0693 2.509e-153 502.0 COG1070@1|root,COG1070@2|Bacteria,4NIJC@976|Bacteroidetes 976|Bacteroidetes G Carbohydrate kinase, FGGY family protein fucK - 2.7.1.5,2.7.1.51 ko:K00848,ko:K00879 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01902,R03014,R03241 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N CMS2_k127_6201804_5 518766.Rmar_0694 5.998e-208 652.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,4NEM0@976|Bacteroidetes 976|Bacteroidetes IQ Rhamnulose-1-phosphate aldolase alcohol dehydrogenase - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 CMS2_k127_6229804_4 331678.Cphamn1_2243 1.95e-21 102.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,1FDC1@1090|Chlorobi 1090|Chlorobi EG Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 CMS2_k127_6229804_2 1379270.AUXF01000002_gene1305 3.238e-37 147.0 COG4636@1|root,COG4636@2|Bacteria,1ZV4E@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative restriction endonuclease - - - - - - - - - - - - Uma2 CMS2_k127_6229804_0 861299.J421_1402 4.728e-304 954.0 COG2091@1|root,COG2091@2|Bacteria,1ZUPU@142182|Gemmatimonadetes 2|Bacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 CMS2_k127_6229804_5 1121935.AQXX01000107_gene583 9.913e-09 61.0 2DKV9@1|root,30FUH@2|Bacteria,1QVHI@1224|Proteobacteria,1S3RE@1236|Gammaproteobacteria,1XKBS@135619|Oceanospirillales 135619|Oceanospirillales S MerT mercuric transport protein - - - ko:K08363 - - - - ko00000,ko02000 1.A.72.1 - - MerT CMS2_k127_6229804_3 1267535.KB906767_gene5033 4.415e-30 124.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZR@57723|Acidobacteria,2JK6A@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_6229804_1 861299.J421_6342 8.969e-49 188.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_6297773_13 234267.Acid_0751 5.176e-26 116.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_6297773_14 1348114.OM33_20420 8.752e-21 96.0 COG1695@1|root,COG1695@2|Bacteria,1N4DF@1224|Proteobacteria,1SBH1@1236|Gammaproteobacteria,2Q31Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K transcriptional regulators - - - - - - - - - - - - PadR CMS2_k127_6297773_16 1379270.AUXF01000002_gene1345 6.36e-12 66.0 COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_6297773_23 1379270.AUXF01000001_gene2556 5.076e-06 51.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000001_gene2556|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_6297773_20 1279009.ADICEAN_03439 8.953e-10 68.0 2EGZQ@1|root,33ARU@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_6297773_2 1396418.BATQ01000157_gene2422 3.079e-139 449.0 COG1294@1|root,COG1294@2|Bacteria,46U7S@74201|Verrucomicrobia,2IUU8@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome bd terminal oxidase subunit II - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II CMS2_k127_6297773_0 945713.IALB_0420 7.723e-190 601.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I CMS2_k127_6297773_17 1249997.JHZW01000003_gene3259 1.028e-11 78.0 COG0457@1|root,COG0596@1|root,COG0457@2|Bacteria,COG0596@2|Bacteria,4NPQR@976|Bacteroidetes,1I2GI@117743|Flavobacteriia,2PI15@252356|Maribacter 976|Bacteroidetes S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1 CMS2_k127_6297773_9 1449063.JMLS01000065_gene2 6.232e-75 277.0 COG1680@1|root,COG1680@2|Bacteria,1VRUW@1239|Firmicutes,4HTF4@91061|Bacilli 91061|Bacilli V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_6297773_19 397287.C807_02442 4.961e-11 74.0 COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,27KVK@186928|unclassified Lachnospiraceae 186801|Clostridia S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 CMS2_k127_6297773_3 926556.Echvi_0939 2.203e-133 437.0 COG0613@1|root,COG0613@2|Bacteria,4PMKK@976|Bacteroidetes,47NYR@768503|Cytophagia 976|Bacteroidetes S PHP domain protein - - - - - - - - - - - - - CMS2_k127_6297773_7 1121946.AUAX01000022_gene3840 6.208e-96 320.0 2DBF0@1|root,2Z8VT@2|Bacteria,2I88D@201174|Actinobacteria,4DIBF@85008|Micromonosporales 201174|Actinobacteria S 3-oxo-5-alpha-steroid 4-dehydrogenase - - 1.3.1.22 ko:K12343 ko00140,map00140 - R02208,R02497,R08954,R10242 RC00145 ko00000,ko00001,ko01000 - - - Steroid_dh CMS2_k127_6297773_8 391625.PPSIR1_16360 9.789e-82 283.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,2YXN2@29|Myxococcales 28221|Deltaproteobacteria GM epimerase dehydratase hpnA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase CMS2_k127_6297773_5 1047013.AQSP01000097_gene1963 8.988e-117 403.0 COG2091@1|root,COG2091@2|Bacteria,2NQ9X@2323|unclassified Bacteria 2|Bacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 CMS2_k127_6297773_11 379066.GAU_2186 8.283e-35 134.0 COG1278@1|root,COG1278@2|Bacteria,1ZTZ4@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Cold shock protein domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS2_k127_6297773_18 861299.J421_2048 1.38e-11 67.0 COG0828@1|root,COG0828@2|Bacteria,1ZU81@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S21 - - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 CMS2_k127_6297773_12 195103.CPF_0311 6.66e-31 126.0 2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia,36JKZ@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - Cytochrom_B561 CMS2_k127_6297773_6 216594.MMAR_3322 2.787e-97 328.0 COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,233TJ@1762|Mycobacteriaceae 201174|Actinobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C CMS2_k127_6297773_10 216594.MMAR_3323 4.387e-67 242.0 COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,234F0@1762|Mycobacteriaceae 201174|Actinobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh CMS2_k127_6297773_21 1385510.N781_16305 2.714e-08 59.0 COG1695@1|root,COG1695@2|Bacteria,1VANP@1239|Firmicutes,4HM54@91061|Bacilli 91061|Bacilli K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR CMS2_k127_6297773_1 251221.35212995 2.429e-150 509.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_6297773_22 234267.Acid_3938 1.297e-06 55.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS2_k127_6297773_25 391735.Veis_1011 0.0002852 53.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,4A9JN@80864|Comamonadaceae 28216|Betaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N CMS2_k127_6297773_26 627192.SLG_15820 0.0006044 48.0 2BZ8N@1|root,33ZRX@2|Bacteria,1N1WI@1224|Proteobacteria,2UDWG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 CMS2_k127_6297773_15 702113.PP1Y_Mpl7969 2.911e-17 92.0 COG4319@1|root,COG4319@2|Bacteria,1N361@1224|Proteobacteria,2UHUN@28211|Alphaproteobacteria,2KC0T@204457|Sphingomonadales 204457|Sphingomonadales M SnoaL-like domain - - - - - - - - - - - - DUF4440 CMS2_k127_6297773_24 1396141.BATP01000018_gene1546 1.887e-05 55.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - ABM,DUF3225,DUF4440,SnoaL_2,SnoaL_3 CMS2_k127_6297773_4 1379270.AUXF01000002_gene1587 6.979e-133 430.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1587|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_6338463_8 1379270.AUXF01000002_gene1173 2.353e-16 94.0 COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,1ZTYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Leishmanolysin - - - - - - - - - - - - Peptidase_M8 CMS2_k127_6338463_3 1047013.AQSP01000134_gene1369 4.85e-192 609.0 COG0403@1|root,COG0403@2|Bacteria,2NQS4@2323|unclassified Bacteria 2|Bacteria E Glycine cleavage system P-protein gcvPA - 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P CMS2_k127_6338463_0 1047013.AQSP01000134_gene1370 2.609e-251 784.0 COG1003@1|root,COG1003@2|Bacteria,2NQCW@2323|unclassified Bacteria 2|Bacteria E Aminotransferase class-V gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P CMS2_k127_6338463_5 374847.Kcr_0603 1.672e-111 372.0 COG3199@1|root,arCOG01350@2157|Archaea 2157|Archaea S ATP-NAD AcoX kinase - - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase CMS2_k127_6338463_7 378806.STAUR_4997 8.028e-85 288.0 COG1028@1|root,COG1028@2|Bacteria,1MUAY@1224|Proteobacteria,42NIM@68525|delta/epsilon subdivisions,2X62N@28221|Deltaproteobacteria,2Z38E@29|Myxococcales 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 CMS2_k127_6338463_6 391735.Veis_2457 1.814e-88 298.0 COG1028@1|root,COG1028@2|Bacteria,1NTI2@1224|Proteobacteria,2VQ4K@28216|Betaproteobacteria,4AJQ5@80864|Comamonadaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 CMS2_k127_6338463_2 660470.Theba_1303 1.06e-202 646.0 COG0627@1|root,COG0627@2|Bacteria 2|Bacteria J Serine hydrolase involved in the detoxification of formaldehyde - - - - - - - - - - - - Esterase,Hepar_II_III,Hepar_II_III_N,OprD CMS2_k127_6338463_4 1122604.JONR01000033_gene31 3.676e-122 398.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1X42V@135614|Xanthomonadales 135614|Xanthomonadales H polyphosphate kinase - - - - - - - - - - - - PPK2 CMS2_k127_6338463_1 1453500.AT05_08085 2.764e-208 655.0 COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1HY7D@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS2_k127_6338463_9 861299.J421_1066 3e-09 65.0 COG3637@1|root,COG3637@2|Bacteria,1ZU6Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl_2 CMS2_k127_6368777_1 696281.Desru_3228 1.888e-21 97.0 29Y33@1|root,30JW2@2|Bacteria,1W3SV@1239|Firmicutes,254NF@186801|Clostridia,266AP@186807|Peptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - CMS2_k127_6368777_0 861299.J421_6359 1.574e-112 392.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6359|- V efflux transmembrane transporter activity - - - - - - - - - - - - - CMS2_k127_6389712_110 382464.ABSI01000010_gene3670 6.689e-05 49.0 COG2863@1|root,COG2863@2|Bacteria,46WZQ@74201|Verrucomicrobia,2IW1M@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome c - - - - - - - - - - - - Cytochrom_C CMS2_k127_6389712_70 1121920.AUAU01000018_gene1775 1.385e-45 171.0 COG2318@1|root,COG2318@2|Bacteria,3Y4HW@57723|Acidobacteria 57723|Acidobacteria S Mycothiol maleylpyruvate isomerase N-terminal domain - - - - - - - - - - - - DinB_2 CMS2_k127_6389712_5 945713.IALB_1080 1.652e-206 650.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_6389712_1 945713.IALB_1079 2.745e-296 915.0 COG1866@1|root,COG1866@2|Bacteria 2|Bacteria H phosphoenolpyruvate carboxykinase (ATP) activity pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP CMS2_k127_6389712_22 247634.GPB2148_1480 3.201e-120 403.0 COG1468@1|root,COG1468@2|Bacteria,1QW0M@1224|Proteobacteria,1RS6B@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 CMS2_k127_6389712_95 1123371.ATXH01000005_gene2038 1.815e-19 98.0 COG2204@1|root,COG2204@2|Bacteria,2GGZ6@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T AAA domain (Cdc48 subfamily) - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_6389712_30 1379270.AUXF01000001_gene1910 1.485e-100 338.0 COG0179@1|root,COG0179@2|Bacteria,1ZTIG@142182|Gemmatimonadetes 2|Bacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - DUF2437,FAA_hydrolase CMS2_k127_6389712_29 1121920.AUAU01000004_gene672 7.597e-103 346.0 COG3342@1|root,COG3342@2|Bacteria,3Y80E@57723|Acidobacteria 57723|Acidobacteria S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028 CMS2_k127_6389712_21 502025.Hoch_6599 2.856e-124 409.0 COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1QA4K@1224|Proteobacteria,42V3B@68525|delta/epsilon subdivisions,2WRIN@28221|Deltaproteobacteria,2YW0I@29|Myxococcales 28221|Deltaproteobacteria E Prephenate dehydrogenase chorismate mutase - - 1.3.1.12 ko:K00210 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - CM_2,PDH CMS2_k127_6389712_85 671143.DAMO_1046 1.936e-32 130.0 COG4747@1|root,COG4747@2|Bacteria,2NR4R@2323|unclassified Bacteria 2|Bacteria S ACT domain protein hom - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00570 R00220,R00996,R01513,R01773,R01775 RC00031,RC00087,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3 CMS2_k127_6389712_81 479434.Sthe_0424 2.236e-34 145.0 COG0010@1|root,COG0010@2|Bacteria,2G8DY@200795|Chloroflexi 200795|Chloroflexi E Belongs to the arginase family - - 3.5.3.1 ko:K01476 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00134 R00551 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase CMS2_k127_6389712_89 627192.SLG_02150 5.717e-29 124.0 COG4625@1|root,COG4625@2|Bacteria,1N0QY@1224|Proteobacteria,2UBPT@28211|Alphaproteobacteria,2KDJU@204457|Sphingomonadales 204457|Sphingomonadales S pathogenesis - - - - - - - - - - - - - CMS2_k127_6389712_106 313603.FB2170_11916 1.696e-06 52.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1HZHJ@117743|Flavobacteriia,2PIWB@252356|Maribacter 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_6389712_96 313603.FB2170_11916 1.643e-17 89.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,1HZHJ@117743|Flavobacteriia,2PIWB@252356|Maribacter 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_6389712_98 96561.Dole_3200 1.467e-12 77.0 2DSXM@1|root,33HUR@2|Bacteria,1NKYR@1224|Proteobacteria,430HU@68525|delta/epsilon subdivisions,2WW10@28221|Deltaproteobacteria,2MNS7@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6389712_80 743720.Psefu_2359 1.571e-35 151.0 COG0300@1|root,COG0300@2|Bacteria,1REEM@1224|Proteobacteria,1S7GY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short CMS2_k127_6389712_60 714943.Mucpa_6877 7.091e-54 201.0 COG0382@1|root,COG0382@2|Bacteria 2|Bacteria H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39,2.5.1.42 ko:K03179,ko:K17105 ko00130,ko00564,ko01100,ko01110,map00130,map00564,map01100,map01110 M00117 R04520,R05000,R05615 RC00209,RC01171,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA CMS2_k127_6389712_66 1206732.BAGD01000074_gene2937 4.905e-49 188.0 COG1597@1|root,COG1597@2|Bacteria,2HHKU@201174|Actinobacteria,4FZ0T@85025|Nocardiaceae 201174|Actinobacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat CMS2_k127_6389712_54 714943.Mucpa_6873 3.206e-65 236.0 COG0611@1|root,COG0611@2|Bacteria 2|Bacteria H thiamine-phosphate kinase activity - - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS CMS2_k127_6389712_12 1254432.SCE1572_19990 2.824e-171 550.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2YUPM@29|Myxococcales 28221|Deltaproteobacteria P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 CMS2_k127_6389712_78 1089550.ATTH01000001_gene1532 4.772e-37 157.0 COG1462@1|root,COG1462@2|Bacteria 2|Bacteria M curli production assembly transport component CsgG - - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - CsgG,FlgT_C CMS2_k127_6389712_62 671143.DAMO_2078 1.813e-52 199.0 COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 CMS2_k127_6389712_8 1379698.RBG1_1C00001G0312 7.879e-190 600.0 COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria 2|Bacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K02887,ko:K03628 ko03010,ko03018,map03010,map03018 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind CMS2_k127_6389712_90 861299.J421_2621 2.904e-26 113.0 COG0816@1|root,COG0816@2|Bacteria,1ZTWG@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX CMS2_k127_6389712_50 861299.J421_2620 6.799e-72 255.0 COG1559@1|root,COG1559@2|Bacteria,1ZTA7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG CMS2_k127_6389712_86 368407.Memar_0261 4.725e-32 133.0 COG0352@1|root,arCOG01089@2157|Archaea,2XSTA@28890|Euryarchaeota,2N9QV@224756|Methanomicrobia 224756|Methanomicrobia H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI CMS2_k127_6389712_68 1215114.BBIU01000014_gene2082 1.028e-46 188.0 COG1073@1|root,COG1073@2|Bacteria,1R67P@1224|Proteobacteria,1S71R@1236|Gammaproteobacteria 1236|Gammaproteobacteria S alpha beta - - - ko:K06889 - - - - ko00000 - - - Abhydrolase_6,Hydrolase_4 CMS2_k127_6389712_59 46234.ANA_C10270 1.633e-58 217.0 COG0053@1|root,COG0053@2|Bacteria,1G0RT@1117|Cyanobacteria,1HJJE@1161|Nostocales 1117|Cyanobacteria U Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer CMS2_k127_6389712_87 861299.J421_2615 5.922e-30 129.0 COG4123@1|root,COG4123@2|Bacteria,1ZTJ4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - - - - - - - - - - - CMS2_k127_6389712_40 379066.GAU_0019 6.701e-86 301.0 COG0312@1|root,COG0312@2|Bacteria,1ZSXT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD CMS2_k127_6389712_19 861299.J421_1204 2.357e-135 449.0 COG0312@1|root,COG0312@2|Bacteria 2|Bacteria S metallopeptidase activity tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD CMS2_k127_6389712_10 1341151.ASZU01000004_gene585 7.714e-174 563.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,4H9PN@91061|Bacilli,27B6R@186824|Thermoactinomycetaceae 91061|Bacilli I AMP-binding enzyme C-terminal domain acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C CMS2_k127_6389712_48 401526.TcarDRAFT_1159 3.745e-75 281.0 COG2021@1|root,COG2021@2|Bacteria,1TQSV@1239|Firmicutes,4H741@909932|Negativicutes 909932|Negativicutes E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 CMS2_k127_6389712_14 1313301.AUGC01000008_gene386 7.157e-158 508.0 COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes 976|Bacteroidetes E Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_6389712_105 493475.GARC_5136 5.564e-07 55.0 COG0236@1|root,COG0236@2|Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP-7 - - - - - - - - - - - PP-binding CMS2_k127_6389712_92 1121940.AUDZ01000005_gene1543 8.752e-21 96.0 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,1S98P@1236|Gammaproteobacteria,1XKU7@135619|Oceanospirillales 135619|Oceanospirillales I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS CMS2_k127_6389712_65 370438.PTH_1946 2.287e-51 188.0 COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,261K2@186807|Peptococcaceae 186801|Clostridia L Belongs to the DNA glycosylase MPG family - - 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco CMS2_k127_6389712_28 861299.J421_2605 2.746e-108 377.0 COG1432@1|root,COG1432@2|Bacteria,1ZSRW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH CMS2_k127_6389712_9 861299.J421_2604 1.346e-189 607.0 COG0318@1|root,COG0318@2|Bacteria,1ZSXP@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C CMS2_k127_6389712_56 861299.J421_2603 1.037e-63 221.0 COG0432@1|root,COG0432@2|Bacteria,1ZV8J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 CMS2_k127_6389712_41 861299.J421_2594 2.611e-84 287.0 COG1403@1|root,COG1403@2|Bacteria,1ZTF1@142182|Gemmatimonadetes 142182|Gemmatimonadetes L HNH nucleases - - - - - - - - - - - - HNH_5 CMS2_k127_6389712_71 1379698.RBG1_1C00001G0519 2.05e-45 177.0 COG0697@1|root,COG0697@2|Bacteria,2NPZZ@2323|unclassified Bacteria 2|Bacteria EG EamA-like transporter family pagO - - ko:K07790 ko02020,map02020 - - - ko00000,ko00001 2.A.7 - - EamA CMS2_k127_6389712_77 1379270.AUXF01000003_gene3668 1.059e-37 156.0 2F0M3@1|root,33TPR@2|Bacteria,1ZUAZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_6389712_99 1379270.AUXF01000003_gene3669 1.622e-12 78.0 2F5SD@1|root,33YB8@2|Bacteria,1ZUXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_6389712_103 580340.Tlie_0450 2.65e-08 61.0 COG4967@1|root,COG4967@2|Bacteria,3TCF5@508458|Synergistetes 508458|Synergistetes NU TIGRFAM prepilin-type N-terminal cleavage methylation domain - - - - - - - - - - - - N_methyl CMS2_k127_6389712_113 666681.M301_2620 0.0005224 49.0 COG4970@1|root,COG4970@2|Bacteria,1NA9B@1224|Proteobacteria,2VV1S@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl CMS2_k127_6389712_17 379066.GAU_0155 8.588e-137 452.0 COG0165@1|root,COG0165@2|Bacteria,1ZSM0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Argininosuccinate lyase C-terminal argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 CMS2_k127_6389712_3 379066.GAU_0644 3.889e-225 719.0 COG5009@1|root,COG5009@2|Bacteria,1ZT3R@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transglycosylase - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase CMS2_k127_6389712_25 2002.JOEQ01000026_gene433 8.568e-115 384.0 COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,4EFWJ@85012|Streptosporangiales 201174|Actinobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b CMS2_k127_6389712_43 379066.GAU_0642 2.295e-81 287.0 COG0520@1|root,COG0520@2|Bacteria,1ZTDV@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS2_k127_6389712_31 1519464.HY22_00475 7.878e-100 348.0 COG1132@1|root,COG1132@2|Bacteria,1FDNB@1090|Chlorobi 1090|Chlorobi V PFAM ABC transporter transmembrane region - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran CMS2_k127_6389712_7 861299.J421_2582 2.159e-198 632.0 COG0745@1|root,COG0745@2|Bacteria,1ZTEW@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT PglZ domain - - - - - - - - - - - - PglZ,Response_reg CMS2_k127_6389712_61 1379270.AUXF01000004_gene3246 1.294e-52 197.0 COG0305@1|root,COG0305@2|Bacteria,1ZUU3@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_C CMS2_k127_6389712_39 1499967.BAYZ01000068_gene1977 4.647e-86 293.0 COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria 2|Bacteria K Transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg CMS2_k127_6389712_67 861299.J421_2580 6.519e-48 177.0 COG0817@1|root,COG0817@2|Bacteria,1ZTKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC CMS2_k127_6389712_72 379066.GAU_0633 2.697e-43 169.0 COG0632@1|root,COG0632@2|Bacteria,1ZTR0@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N CMS2_k127_6389712_15 1379270.AUXF01000004_gene3254 1.028e-148 478.0 COG2255@1|root,COG2255@2|Bacteria,1ZT9W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N CMS2_k127_6389712_27 861299.J421_2570 1.037e-113 377.0 COG0809@1|root,COG0809@2|Bacteria,1ZSV2@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth CMS2_k127_6389712_18 861299.J421_2569 1.018e-135 441.0 COG0343@1|root,COG0343@2|Bacteria,1ZSRS@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) - - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT CMS2_k127_6389712_91 379066.GAU_0626 7.92e-21 96.0 COG1862@1|root,COG1862@2|Bacteria,1ZU5F@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Preprotein translocase subunit - - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC CMS2_k127_6389712_73 379066.GAU_0625 3.96e-43 164.0 COG0242@1|root,COG0242@2|Bacteria,1ZTPP@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase CMS2_k127_6389712_37 861299.J421_2566 1.032e-89 307.0 COG0223@1|root,COG0223@2|Bacteria,1ZTE5@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N CMS2_k127_6389712_82 404589.Anae109_1348 1.001e-33 137.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42NTP@68525|delta/epsilon subdivisions,2WQME@28221|Deltaproteobacteria,2YVSW@29|Myxococcales 28221|Deltaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) tenI GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI CMS2_k127_6389712_100 269799.Gmet_2933 3.6e-12 72.0 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,42WUA@68525|delta/epsilon subdivisions,2WSM2@28221|Deltaproteobacteria,43VNW@69541|Desulfuromonadales 28221|Deltaproteobacteria H ThiS family thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS CMS2_k127_6389712_36 443143.GM18_3702 2.828e-93 314.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2WIUI@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG CMS2_k127_6389712_45 861299.J421_2565 1.399e-79 280.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1ZTGM@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB CMS2_k127_6389712_93 1996.JOFO01000003_gene6351 2.486e-20 102.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4EGFA@85012|Streptosporangiales 201174|Actinobacteria KLT PASTA pknL GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase CMS2_k127_6389712_51 1122925.KB895379_gene2347 1.954e-69 244.0 COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,26Q92@186822|Paenibacillaceae 91061|Bacilli G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim CMS2_k127_6389712_75 379066.GAU_0620 1.485e-40 157.0 COG0526@1|root,COG0526@2|Bacteria,1ZTMM@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Glutathione peroxidase - - - - - - - - - - - - AhpC-TSA CMS2_k127_6389712_114 309801.trd_0687 0.0009997 50.0 COG4856@1|root,COG4856@2|Bacteria,2G75D@200795|Chloroflexi,27YNP@189775|Thermomicrobia 189775|Thermomicrobia S YbbR-like protein - - - - - - - - - - - - YbbR CMS2_k127_6389712_38 379066.GAU_0619 7.611e-89 304.0 COG0533@1|root,COG0533@2|Bacteria,1ZT0P@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 CMS2_k127_6389712_58 861299.J421_2559 1.381e-59 217.0 COG0682@1|root,COG0682@2|Bacteria,1ZSYY@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT CMS2_k127_6389712_49 861299.J421_6160 2.326e-74 259.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_6160|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - CMS2_k127_6389712_101 391625.PPSIR1_11100 1.522e-09 71.0 COG0457@1|root,COG0457@2|Bacteria 391625.PPSIR1_11100|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_6389712_53 525904.Tter_0622 1.429e-67 255.0 COG4733@1|root,COG4733@2|Bacteria,2NPFU@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF2961) - - - - - - - - - - - - DUF2961 CMS2_k127_6389712_6 861299.J421_6286 6.774e-199 635.0 COG3653@1|root,COG3653@2|Bacteria,1ZTFY@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 CMS2_k127_6389712_94 1403819.BATR01000102_gene3401 7.389e-20 97.0 COG0736@1|root,COG0736@2|Bacteria,46T5U@74201|Verrucomicrobia,2IUTE@203494|Verrucomicrobiae 203494|Verrucomicrobiae I 4'-phosphopantetheinyl transferase superfamily acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS CMS2_k127_6389712_64 861299.J421_2552 3.723e-52 192.0 COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD CMS2_k127_6389712_47 326427.Cagg_2943 2.086e-75 264.0 COG3191@1|root,COG3191@2|Bacteria,2G6BG@200795|Chloroflexi,3766W@32061|Chloroflexia 32061|Chloroflexia EQ PFAM peptidase S58, DmpA - - - - - - - - - - - - Peptidase_S58 CMS2_k127_6389712_76 861299.J421_2546 1.281e-39 160.0 COG1597@1|root,COG1597@2|Bacteria,1ZU66@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Diacylglycerol kinase catalytic domain (presumed) - - 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_cat CMS2_k127_6389712_107 694427.Palpr_2650 1.706e-06 63.0 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,2FPH8@200643|Bacteroidia,22WTX@171551|Porphyromonadaceae 976|Bacteroidetes M TamB, inner membrane protein subunit of TAM complex - - - - - - - - - - - - TamB CMS2_k127_6389712_33 379066.GAU_0608 2.617e-97 344.0 COG4775@1|root,COG4775@2|Bacteria,1ZSY7@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA CMS2_k127_6389712_13 316274.Haur_3267 1.356e-159 516.0 COG0493@1|root,COG0493@2|Bacteria,2G6SR@200795|Chloroflexi,374Z6@32061|Chloroflexia 32061|Chloroflexia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - Pyr_redox_2 CMS2_k127_6389712_63 861299.J421_2533 2.637e-52 191.0 COG2096@1|root,COG2096@2|Bacteria,1ZT4I@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans CMS2_k127_6389712_55 485913.Krac_5497 3.91e-65 234.0 COG0384@1|root,COG0384@2|Bacteria,2G8NU@200795|Chloroflexi 200795|Chloroflexi S PFAM Phenazine biosynthesis PhzC PhzF protein - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF CMS2_k127_6389712_44 1121403.AUCV01000024_gene3448 1.055e-80 282.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2MIGY@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI CMS2_k127_6389712_16 379066.GAU_0602 2.791e-142 458.0 COG0568@1|root,COG0568@2|Bacteria,1ZSNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 CMS2_k127_6389712_11 379066.GAU_0600 4.021e-172 554.0 COG0277@1|root,COG0277@2|Bacteria,1ZT11@142182|Gemmatimonadetes 142182|Gemmatimonadetes C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 CMS2_k127_6389712_74 1382304.JNIL01000001_gene3130 2.201e-41 168.0 COG0277@1|root,COG0277@2|Bacteria,1TQMR@1239|Firmicutes,4HDHV@91061|Bacilli,27A3V@186823|Alicyclobacillaceae 91061|Bacilli C FAD binding domain - - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 CMS2_k127_6389712_24 1379270.AUXF01000004_gene3287 1.103e-115 389.0 COG0247@1|root,COG0247@2|Bacteria,1ZSTK@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S binding domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG CMS2_k127_6389712_88 1379270.AUXF01000004_gene3295 6.17e-30 132.0 COG0354@1|root,COG0354@2|Bacteria,1ZTMX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Glycine cleavage T-protein C-terminal barrel domain - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C CMS2_k127_6389712_35 1261545.MBE-HAL_1764 6.12e-96 329.0 COG1914@1|root,arCOG04531@2157|Archaea,2XU6H@28890|Euryarchaeota,23UME@183963|Halobacteria 183963|Halobacteria P COG1914 Mn2 and Fe2 transporters of the NRAMP family mntH2 - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp CMS2_k127_6389712_69 886293.Sinac_6848 1.456e-46 182.0 COG0451@1|root,COG0451@2|Bacteria,2J2KW@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase CMS2_k127_6389712_57 591157.SSLG_05643 8.316e-62 224.0 COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria 201174|Actinobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ CMS2_k127_6389712_102 1440053.JOEI01000038_gene190 1.162e-08 65.0 COG3595@1|root,COG3595@2|Bacteria,2GKT3@201174|Actinobacteria 201174|Actinobacteria S domain, Protein - - - - - - - - - - - - DUF4097 CMS2_k127_6389712_111 639030.JHVA01000001_gene3427 0.0001355 54.0 COG0467@1|root,COG0467@2|Bacteria,3Y2U8@57723|Acidobacteria,2JIQ8@204432|Acidobacteriia 204432|Acidobacteriia T KaiC - - - ko:K08482 - - - - ko00000 - - - ATPase CMS2_k127_6389712_112 443144.GM21_0616 0.0001384 55.0 COG0457@1|root,COG0457@2|Bacteria,1PEPM@1224|Proteobacteria,42Y8V@68525|delta/epsilon subdivisions,2WU79@28221|Deltaproteobacteria,43TE3@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_8 CMS2_k127_6389712_23 1191523.MROS_2246 2.216e-118 394.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 CMS2_k127_6389712_79 946483.Cenrod_0353 1.26e-36 158.0 COG0726@1|root,COG0726@2|Bacteria 2|Bacteria G polysaccharide deacetylase cda1 GO:0000003,GO:0000272,GO:0003006,GO:0005575,GO:0005618,GO:0005619,GO:0005623,GO:0005631,GO:0005975,GO:0005976,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006037,GO:0006039,GO:0006040,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009272,GO:0009277,GO:0009653,GO:0009987,GO:0010383,GO:0010927,GO:0016043,GO:0016052,GO:0016998,GO:0017144,GO:0019953,GO:0022402,GO:0022411,GO:0022413,GO:0022414,GO:0022607,GO:0030154,GO:0030312,GO:0030435,GO:0030437,GO:0030476,GO:0031160,GO:0031505,GO:0032502,GO:0032505,GO:0032989,GO:0034218,GO:0034232,GO:0034293,GO:0042244,GO:0042546,GO:0042737,GO:0043170,GO:0043934,GO:0043935,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044277,GO:0044426,GO:0044462,GO:0044464,GO:0044703,GO:0045229,GO:0046348,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0051321,GO:0051704,GO:0070590,GO:0070591,GO:0070726,GO:0070910,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071852,GO:0071853,GO:0071854,GO:0071940,GO:0071944,GO:0071966,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903046 1.7.3.3,3.5.1.104,3.5.1.41,3.5.2.5 ko:K00365,ko:K01452,ko:K16842,ko:K22278 ko00230,ko00232,ko00520,ko01100,ko01120,map00230,map00232,map00520,map01100,map01120 M00546 R02106,R02333,R02425,R07981 RC00166,RC00300,RC00680,RC02107,RC02551 ko00000,ko00001,ko00002,ko01000 - - - OHCU_decarbox,Polysacc_deac_1 CMS2_k127_6389712_46 861299.J421_0742 5.098e-77 265.0 COG1011@1|root,COG1011@2|Bacteria 2|Bacteria S phosphatase activity - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase CMS2_k127_6389712_109 1454007.JAUG01000073_gene4091 2.113e-05 58.0 COG0383@1|root,COG0383@2|Bacteria,4NEC3@976|Bacteroidetes,1IX18@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolases family 38 C-terminal domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Glyco_hydro_38,Glyco_hydro_38C CMS2_k127_6389712_2 1095767.CAHD01000240_gene2484 5.884e-271 875.0 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4F0VV@85016|Cellulomonadaceae 201174|Actinobacteria C of components of various dehydrogenase complexes kgd GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1248c 2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr CMS2_k127_6389712_26 391625.PPSIR1_39705 9.821e-114 389.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42V54@68525|delta/epsilon subdivisions,2WSDI@28221|Deltaproteobacteria,2Z0J9@29|Myxococcales 28221|Deltaproteobacteria BQ Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl CMS2_k127_6389712_84 861299.J421_2472 4.676e-33 135.0 COG0762@1|root,COG0762@2|Bacteria,1ZTUJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT CMS2_k127_6389712_97 330214.NIDE3568 4.237e-16 87.0 COG1872@1|root,COG1872@2|Bacteria 2|Bacteria I DUF167 yggU - - ko:K09131 - - - - ko00000 - - - DUF167 CMS2_k127_6389712_0 243233.MCA1545 0.0 1631.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales 135618|Methylococcales H Vitamin B12 dependent methionine synthase, activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans CMS2_k127_6389712_4 379066.GAU_0558 2.308e-220 700.0 COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Methylenetetrahydrofolate reductase - - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR,S-methyl_trans CMS2_k127_6389712_20 861299.J421_2940 1.119e-128 428.0 COG0793@1|root,COG0793@2|Bacteria,1ZSUF@142182|Gemmatimonadetes 142182|Gemmatimonadetes M tail specific protease - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,Peptidase_S41 CMS2_k127_6389712_42 292459.STH2612 3.051e-83 295.0 COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,24DV3@186801|Clostridia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF4173 CMS2_k127_6389712_52 861299.J421_2457 5.931e-68 247.0 COG1721@1|root,COG1721@2|Bacteria 2|Bacteria E protein (some members contain a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - DUF11,DUF58 CMS2_k127_6389712_32 292459.STH463 5.145e-99 336.0 COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia 186801|Clostridia S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS2_k127_6389712_104 867845.KI911784_gene2913 9.189e-08 64.0 2E0NP@1|root,32W7Q@2|Bacteria,2G9D8@200795|Chloroflexi,375QK@32061|Chloroflexia 32061|Chloroflexia S Domain of unknown function (DUF4350) - - - - - - - - - - - - DUF4350 CMS2_k127_6389712_108 1128421.JAGA01000002_gene1062 2.78e-06 58.0 COG5180@1|root,COG5180@2|Bacteria,2NRZJ@2323|unclassified Bacteria 2|Bacteria A pathogenesis CP_0034 - - ko:K02417,ko:K02519 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044,ko03012,ko03029 3.A.6.2,3.A.6.3 - - GPDPase_memb CMS2_k127_6389712_34 861299.J421_2456 2.213e-96 338.0 COG1300@1|root,COG1714@1|root,COG1300@2|Bacteria,COG1714@2|Bacteria 2|Bacteria S RDD family - - - ko:K06384 - - - - ko00000 - - - RDD,SpoIIM CMS2_k127_6389712_83 1144275.COCOR_00258 4.639e-33 130.0 COG0845@1|root,COG0845@2|Bacteria,1R50D@1224|Proteobacteria 1224|Proteobacteria M COG0845 Membrane-fusion protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS2_k127_6389858_2 702450.CUW_2599 6.692e-24 113.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF2268,Peptidase_M1 CMS2_k127_6389858_1 1380355.JNIJ01000011_gene815 1.811e-56 203.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria,3JZ7D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_38,rve CMS2_k127_6389858_0 926550.CLDAP_28910 7.039e-76 259.0 COG4122@1|root,COG4122@2|Bacteria,2G97D@200795|Chloroflexi 200795|Chloroflexi S O-methyltransferase - - - - - - - - - - - - Methyltransf_24,Methyltransf_3 CMS2_k127_6396832_6 861299.J421_3135 2.937e-41 160.0 COG1381@1|root,COG1381@2|Bacteria,1ZTHP@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N CMS2_k127_6396832_2 338963.Pcar_0832 2.467e-126 427.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,43TPN@69541|Desulfuromonadales 28221|Deltaproteobacteria J Elongation factor SelB winged helix 3 selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 CMS2_k127_6396832_7 861299.J421_3136 4.881e-28 119.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DctA-YdbH CMS2_k127_6396832_0 861299.J421_3137 0.0 1142.0 COG0542@1|root,COG0542@2|Bacteria,1ZT9Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N CMS2_k127_6396832_5 861299.J421_3139 6.556e-47 176.0 COG0590@1|root,COG0590@2|Bacteria,1ZTW9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33,3.8.1.5 ko:K01563,ko:K11991 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223 RC00477,RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000,ko03016 - - - MafB19-deam CMS2_k127_6396832_4 1144275.COCOR_02487 8.521e-52 198.0 COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,42S4E@68525|delta/epsilon subdivisions,2WNJ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Thioredoxin - - - - - - - - - - - - SurA_N_3,Thioredoxin_4 CMS2_k127_6396832_9 5911.EAR93642 9.437e-06 59.0 KOG1125@1|root,KOG1125@2759|Eukaryota,3ZB74@5878|Ciliophora 5878|Ciliophora S Tetratricopeptide repeat - - - ko:K13342 ko04146,map04146 - - - ko00000,ko00001,ko04131 3.A.20.1 - - TPR_11,TPR_17,TPR_8 CMS2_k127_6396832_1 1168034.FH5T_03280 2.631e-146 499.0 COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins dppX - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 CMS2_k127_6396832_3 861299.J421_6158 1.292e-77 268.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 2|Bacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 CMS2_k127_6396832_8 998674.ATTE01000001_gene2510 1.546e-06 54.0 COG1100@1|root,COG1100@2|Bacteria,1RIAW@1224|Proteobacteria,1S6H6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM Small GTP-binding protein - - - - - - - - - - - - Ras CMS2_k127_6428824_4 1279009.ADICEAN_00024 1.401e-05 47.0 COG1520@1|root,COG1520@2|Bacteria,4PNAK@976|Bacteroidetes,47YAF@768503|Cytophagia 976|Bacteroidetes S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - CMS2_k127_6428824_3 234267.Acid_6108 3.245e-35 145.0 COG4798@1|root,COG4798@2|Bacteria 2|Bacteria E methyltransferase - - - - - - - - - - - - Acetyltransf_1,FAD_binding_4,Methyltransf_11,Methyltransf_25,Methyltransf_31,SAM_MT CMS2_k127_6428824_1 234267.Acid_6478 3.278e-97 322.0 COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria 57723|Acidobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - ABC_tran CMS2_k127_6428824_2 1379270.AUXF01000002_gene1485 8.063e-65 236.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid blaB3 - - - - - - - - - - - Lactamase_B CMS2_k127_6428824_0 504472.Slin_3379 1.351e-105 355.0 COG2866@1|root,COG2866@2|Bacteria,4P1T6@976|Bacteroidetes 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS2_k127_6438645_22 1144275.COCOR_00258 3.224e-32 129.0 COG0845@1|root,COG0845@2|Bacteria,1R50D@1224|Proteobacteria 1224|Proteobacteria M COG0845 Membrane-fusion protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS2_k127_6438645_28 1265503.KB905165_gene1042 6.467e-14 77.0 COG0607@1|root,COG0607@2|Bacteria,1RHVM@1224|Proteobacteria,1SD9C@1236|Gammaproteobacteria,2Q78Y@267889|Colwelliaceae 1236|Gammaproteobacteria P Rhodanese Homology Domain pspE GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K03972 - - - - ko00000 - - iE2348C_1286.E2348C_1500,iECABU_c1320.ECABU_c15910,iSDY_1059.SDY_1936,ic_1306.c1779 Rhodanese CMS2_k127_6438645_16 383372.Rcas_1178 6.978e-62 218.0 COG0500@1|root,COG2226@2|Bacteria,2G8IN@200795|Chloroflexi 200795|Chloroflexi Q ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 CMS2_k127_6438645_6 1121104.AQXH01000001_gene1902 1.464e-136 456.0 COG2866@1|root,COG2866@2|Bacteria,4NH4I@976|Bacteroidetes 976|Bacteroidetes E Peptidase M14 - - - - - - - - - - - - Peptidase_M14 CMS2_k127_6438645_10 761193.Runsl_3132 3.137e-86 310.0 COG2866@1|root,COG2866@2|Bacteria,4NHBS@976|Bacteroidetes,47MR4@768503|Cytophagia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 CMS2_k127_6438645_0 521674.Plim_1395 9.933e-207 651.0 COG1027@1|root,COG1027@2|Bacteria,2J4YC@203682|Planctomycetes 203682|Planctomycetes E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 CMS2_k127_6438645_18 1095769.CAHF01000022_gene361 4.024e-48 179.0 290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,2VZ0V@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6438645_12 1185876.BN8_03080 5.316e-80 277.0 COG0189@1|root,COG0189@2|Bacteria,4NJI8@976|Bacteroidetes,47JGF@768503|Cytophagia 976|Bacteroidetes HJ RimK-like ATP-grasp domain - - - - - - - - - - - - RimK CMS2_k127_6438645_15 1340493.JNIF01000004_gene1025 1.365e-63 244.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - ko:K07004 - - - - ko00000 - - - PKD,PPC,Peptidase_M10,Peptidase_M28,SLH CMS2_k127_6438645_3 1121930.AQXG01000001_gene1102 3.799e-171 563.0 COG2091@1|root,COG2091@2|Bacteria,4NGXG@976|Bacteroidetes 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_6438645_17 861299.J421_0243 5.764e-51 202.0 COG1413@1|root,COG4219@1|root,COG1413@2|Bacteria,COG4219@2|Bacteria,1ZUUA@142182|Gemmatimonadetes 142182|Gemmatimonadetes U BlaR1 peptidase M56 - - - - - - - - - - - - HEAT_2,Peptidase_M56 CMS2_k127_6438645_25 886293.Sinac_6279 5.474e-25 110.0 COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes 203682|Planctomycetes K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R CMS2_k127_6438645_4 452637.Oter_1890 3.467e-144 490.0 COG0577@1|root,COG0577@2|Bacteria,46UZM@74201|Verrucomicrobia 74201|Verrucomicrobia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_6438645_26 234267.Acid_2610 1.213e-23 103.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_6438645_8 1121405.dsmv_2612 4.924e-129 421.0 COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria,2MJ2T@213118|Desulfobacterales 28221|Deltaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N CMS2_k127_6438645_23 1121405.dsmv_2611 6.703e-27 112.0 COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales 28221|Deltaproteobacteria F Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase CMS2_k127_6438645_5 1121405.dsmv_2609 1.615e-142 468.0 COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,42PSH@68525|delta/epsilon subdivisions,2WJYZ@28221|Deltaproteobacteria,2MIFM@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF1611_N) Rossmann-like domain - - - - - - - - - - - - DUF1611,DUF1611_N CMS2_k127_6438645_11 314230.DSM3645_13890 2.135e-81 278.0 COG3271@1|root,COG3271@2|Bacteria,2J35W@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS2_k127_6438645_1 502025.Hoch_5784 1.858e-174 559.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria 28221|Deltaproteobacteria HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK CMS2_k127_6438645_7 502025.Hoch_5783 8.098e-135 445.0 COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,42PBG@68525|delta/epsilon subdivisions,2WK4S@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Glutamate-cysteine ligase - - - - - - - - - - - - GCS2 CMS2_k127_6438645_14 261292.Nit79A3_2848 2.058e-64 233.0 COG3931@1|root,COG3931@2|Bacteria,1PWF0@1224|Proteobacteria,2VZYZ@28216|Betaproteobacteria,373WJ@32003|Nitrosomonadales 28216|Betaproteobacteria E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase CMS2_k127_6438645_2 251221.35211765 1.937e-171 572.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_6438645_27 1117319.PSPO_20201 7.132e-23 106.0 COG1695@1|root,COG1695@2|Bacteria,1N4DF@1224|Proteobacteria,1SBH1@1236|Gammaproteobacteria,2Q31Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K transcriptional regulators - - - - - - - - - - - - PadR CMS2_k127_6438645_21 1122179.KB890422_gene2260 6.793e-33 145.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - - - - - - - - - - MAM,Peptidase_M6 CMS2_k127_6438645_20 1049564.TevJSym_ap00120 3.861e-35 136.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,1J6NS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 CMS2_k127_6438645_13 452637.Oter_0665 7.733e-72 254.0 COG2890@1|root,COG2890@2|Bacteria 2|Bacteria J protein-(glutamine-N5) methyltransferase activity - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - Methyltransf_25 CMS2_k127_6438645_30 1254432.SCE1572_50095 1.04e-08 66.0 COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,4393M@68525|delta/epsilon subdivisions,2X49J@28221|Deltaproteobacteria,2YYJG@29|Myxococcales 28221|Deltaproteobacteria KLT Family membership - - - - - - - - - - - - AAA_16,Pkinase CMS2_k127_6438645_9 861299.J421_0829 2.03e-112 378.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - GAF,HTH_8,Sigma54_activat CMS2_k127_6438645_19 1379270.AUXF01000003_gene3496 1.445e-45 177.0 COG3437@1|root,COG3437@2|Bacteria,1ZSX2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HD domain - - - - - - - - - - - - HD,Response_reg CMS2_k127_6493891_7 765910.MARPU_00500 1.74e-23 103.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales 135613|Chromatiales E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N CMS2_k127_6493891_2 903818.KI912269_gene273 7.307e-184 586.0 COG0674@1|root,COG0674@2|Bacteria,3Y3NB@57723|Acidobacteria 57723|Acidobacteria C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.7 ko:K00186 ko00280,ko01100,map00280,map01100 - R07160,R08566,R08567 RC00004,RC02833,RC02856 br01601,ko00000,ko00001,ko01000 - - - PFOR_II,POR_N CMS2_k127_6493891_1 1121920.AUAU01000021_gene2510 6.158e-222 696.0 COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,3Y3G3@57723|Acidobacteria 57723|Acidobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.7 ko:K00187 ko00280,ko01100,map00280,map01100 - R07160,R08566,R08567 RC00004,RC02833,RC02856 br01601,ko00000,ko00001,ko01000 - - - POR,TPP_enzyme_C CMS2_k127_6493891_5 1191523.MROS_2406 1.075e-99 338.0 COG0686@1|root,COG0686@2|Bacteria 2|Bacteria E alanine dehydrogenase activity ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N CMS2_k127_6493891_3 1449080.JQMV01000003_gene2007 1.657e-168 539.0 COG0427@1|root,COG0427@2|Bacteria,1WJIT@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro CMS2_k127_6493891_4 1033734.CAET01000048_gene1678 8.643e-135 437.0 COG0451@1|root,COG0451@2|Bacteria,1TSUN@1239|Firmicutes,4HA3D@91061|Bacilli,1ZAUE@1386|Bacillus 91061|Bacilli GM GDP-mannose 4,6 dehydratase - - - - - - - - - - - - Epimerase CMS2_k127_6493891_0 1047013.AQSP01000091_gene644 1.819e-228 719.0 COG1304@1|root,COG1304@2|Bacteria 2|Bacteria C FMN binding yahG - - - - - - - - - - - DUF1116,FMN_dh,Glu_synthase CMS2_k127_6493891_6 1047013.AQSP01000091_gene643 2.191e-75 259.0 COG3383@1|root,COG3383@2|Bacteria,2NNXH@2323|unclassified Bacteria 2|Bacteria C Iron hydrogenase small subunit - - 1.12.1.3,1.17.1.9,1.6.5.3 ko:K00123,ko:K00336,ko:K18332 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - iHN637.CLJU_RS03470 Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_21,Fer4_7,NADH-G_4Fe-4S_3 CMS2_k127_6497842_23 1047013.AQSP01000142_gene167 3.881e-05 55.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity ywhL - - - - - - - - - - - Phosphoesterase CMS2_k127_6497842_11 631454.N177_4094 6.123e-50 193.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,1JQ4G@119043|Rhodobiaceae 28211|Alphaproteobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 CMS2_k127_6497842_6 861299.J421_1476 2.186e-130 423.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 CMS2_k127_6497842_4 861299.J421_1475 1.149e-139 458.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 CMS2_k127_6497842_5 234267.Acid_0432 6.421e-134 443.0 COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria 57723|Acidobacteria C NapC/NirT cytochrome c family, N-terminal region - - - - - - - - - - - - Cytochrom_NNT CMS2_k127_6497842_1 1120966.AUBU01000005_gene3809 0.0 1311.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes 976|Bacteroidetes T PFAM BNR Asp-box repeat - - - - - - - - - - - - BNR_6,Sortilin-Vps10 CMS2_k127_6497842_3 526225.Gobs_5012 3.761e-162 524.0 COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4ESJT@85013|Frankiales 201174|Actinobacteria G PFAM Glycosyl transferase, family 20 otsA - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase CMS2_k127_6497842_13 1121033.AUCF01000011_gene1829 1.226e-39 156.0 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,2JS5Q@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase CMS2_k127_6497842_19 1000565.METUNv1_03628 6.663e-15 83.0 28TB7@1|root,2ZFJR@2|Bacteria,1PACM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_6497842_14 290397.Adeh_0216 3.965e-39 158.0 COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,42RNT@68525|delta/epsilon subdivisions,2WNHN@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS2_k127_6497842_20 861299.J421_2041 2.168e-13 79.0 COG1629@1|root,COG1629@2|Bacteria,1ZTI4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg CMS2_k127_6497842_0 237368.SCABRO_03209 0.0 1448.0 COG0243@1|root,COG1104@1|root,COG0243@2|Bacteria,COG1104@2|Bacteria,2J1TP@203682|Planctomycetes 203682|Planctomycetes CE Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Aminotran_5,Molybdopterin,Molydop_binding CMS2_k127_6497842_7 518766.Rmar_2091 3.075e-122 404.0 COG0624@1|root,COG0624@2|Bacteria,4NJEK@976|Bacteroidetes 976|Bacteroidetes E TIGRFAM amidase, hydantoinase carbamoylase family - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 CMS2_k127_6497842_24 1415755.JQLV01000001_gene3579 0.0006314 45.0 2E7VF@1|root,332A9@2|Bacteria,1NFEY@1224|Proteobacteria,1SDX7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF3311 CMS2_k127_6497842_2 1044.EH31_09160 6.784e-176 569.0 COG0591@1|root,COG0591@2|Bacteria,1MWX6@1224|Proteobacteria,2TU5R@28211|Alphaproteobacteria,2K0PM@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS2_k127_6497842_9 861299.J421_1717 1.382e-67 238.0 COG4232@1|root,COG4232@2|Bacteria,1ZSQP@142182|Gemmatimonadetes 142182|Gemmatimonadetes CO Cytochrome C biogenesis protein transmembrane region - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbD CMS2_k127_6497842_15 861299.J421_1716 4.5e-31 138.0 COG0526@1|root,COG0526@2|Bacteria,1ZTV9@142182|Gemmatimonadetes 142182|Gemmatimonadetes CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA CMS2_k127_6497842_16 1379270.AUXF01000001_gene2770 2.484e-26 111.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA CMS2_k127_6497842_21 379066.GAU_2624 1.107e-10 67.0 COG1225@1|root,COG1225@2|Bacteria,1ZUGC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Redoxin - - - - - - - - - - - - AhpC-TSA CMS2_k127_6497842_10 247490.KSU1_B0346 3.721e-57 214.0 COG1028@1|root,COG1028@2|Bacteria,2IZBD@203682|Planctomycetes 203682|Planctomycetes IQ Short chain dehydrogenase - - - - - - - - - - - - adh_short_C2 CMS2_k127_6497842_17 216432.CA2559_00325 1.792e-25 119.0 COG5635@1|root,COG5635@2|Bacteria,4PKU0@976|Bacteroidetes 976|Bacteroidetes T Domain of unknown function (DUF4062) - - - - - - - - - - - - DUF4062 CMS2_k127_6497842_8 1047013.AQSP01000105_gene1436 1.484e-83 288.0 COG2421@1|root,COG2421@2|Bacteria,2NR72@2323|unclassified Bacteria 2|Bacteria C Acetamidase/Formamidase family - - - - - - - - - - - - FmdA_AmdA CMS2_k127_6497842_12 861299.J421_1752 2.624e-44 183.0 2DWGD@1|root,3407S@2|Bacteria,1ZV24@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg CMS2_k127_6516626_10 103733.JNYO01000046_gene6556 3.114e-24 114.0 COG0457@1|root,COG2197@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,COG3899@2|Bacteria,2IAPV@201174|Actinobacteria,4E3H0@85010|Pseudonocardiales 201174|Actinobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,GerE CMS2_k127_6516626_7 1173024.KI912151_gene1563 7.202e-41 155.0 COG2947@1|root,COG2947@2|Bacteria,1G5R2@1117|Cyanobacteria,1JIMG@1189|Stigonemataceae 1117|Cyanobacteria S EVE domain - - - - - - - - - - - - EVE CMS2_k127_6516626_1 264732.Moth_1680 5.718e-215 691.0 COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,42F3U@68295|Thermoanaerobacterales 186801|Clostridia KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS16615 ACT_4,HD_4,RelA_SpoT,TGS CMS2_k127_6516626_5 861299.J421_3564 2.564e-69 242.0 COG2003@1|root,COG2003@2|Bacteria,1ZTFU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E RadC-like JAB domain - - - ko:K03630 - - - - ko00000 - - - RadC CMS2_k127_6516626_0 861299.J421_3566 0.0 1125.0 COG0653@1|root,COG0653@2|Bacteria,1ZSMK@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW CMS2_k127_6516626_6 861299.J421_3567 2.439e-43 164.0 COG1057@1|root,COG1057@2|Bacteria,1ZTT1@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like CMS2_k127_6516626_9 880073.Calab_0057 1.153e-28 126.0 COG4105@1|root,COG4105@2|Bacteria,2NQ7U@2323|unclassified Bacteria 2|Bacteria S Outer membrane lipoprotein yfiO - - ko:K05807,ko:K08309 - - - - ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 - YfiO CMS2_k127_6516626_11 945713.IALB_1072 2.01e-05 56.0 COG0457@1|root,COG0457@2|Bacteria 945713.IALB_1072|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_6516626_8 1125863.JAFN01000001_gene1608 1.13e-36 147.0 COG0457@1|root,COG0457@2|Bacteria,1N5BD@1224|Proteobacteria,42U63@68525|delta/epsilon subdivisions,2WQUR@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TPR repeat - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8 CMS2_k127_6516626_4 1307759.JOMJ01000004_gene2869 2.397e-87 304.0 COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2M9BR@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,GtrA CMS2_k127_6516626_3 861299.J421_0145 1.018e-155 497.0 COG0451@1|root,COG0451@2|Bacteria,1ZUJJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes GM 3-beta hydroxysteroid dehydrogenase/isomerase family - - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd CMS2_k127_6516626_2 861299.J421_0144 1.363e-176 563.0 COG1004@1|root,COG1004@2|Bacteria,1ZTH3@142182|Gemmatimonadetes 2|Bacteria M UDP binding domain ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N CMS2_k127_6551281_11 269482.Bcep1808_4285 5.897e-60 217.0 COG3328@1|root,COG3328@2|Bacteria,1R81T@1224|Proteobacteria,2W75T@28216|Betaproteobacteria,1KDWC@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM transposase, mutator type - - - - - - - - - - - - Transposase_mut CMS2_k127_6551281_2 880073.Calab_0802 2.205e-192 623.0 COG0591@1|root,COG0591@2|Bacteria,2NPAX@2323|unclassified Bacteria 2|Bacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF CMS2_k127_6551281_5 401526.TcarDRAFT_2158 1.859e-124 408.0 COG1063@1|root,COG1063@2|Bacteria,1U5GN@1239|Firmicutes 1239|Firmicutes E PFAM Alcohol dehydrogenase zinc-binding domain protein - - - - - - - - - - - - ADH_N,ADH_zinc_N CMS2_k127_6551281_7 1266908.AQPB01000042_gene1065 1.205e-97 334.0 COG1914@1|root,COG1914@2|Bacteria,1MWET@1224|Proteobacteria,1RY2N@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Mn2 and Fe2 transporters of the NRAMP family Z012_09610 - - - - - - - - - - - Nramp CMS2_k127_6551281_3 945713.IALB_2412 2.096e-172 555.0 COG0076@1|root,COG0076@2|Bacteria 2|Bacteria E glutamate decarboxylase activity ddc - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC CMS2_k127_6551281_20 1384056.N787_04785 4.772e-22 107.0 COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales 135614|Xanthomonadales S Putative adhesin - - - - - - - - - - - - DUF4097 CMS2_k127_6551281_23 1382304.JNIL01000001_gene10 0.0001007 52.0 COG1664@1|root,COG1664@2|Bacteria 2|Bacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin CMS2_k127_6551281_14 1379270.AUXF01000001_gene2634 2.116e-42 162.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_6551281_6 316274.Haur_1732 4.881e-115 374.0 COG0479@1|root,COG0479@2|Bacteria,2GACG@200795|Chloroflexi,3758X@32061|Chloroflexia 32061|Chloroflexia C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 CMS2_k127_6551281_0 1521187.JPIM01000142_gene2782 0.0 1037.0 COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia 32061|Chloroflexia C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS2_k127_6551281_10 1128421.JAGA01000003_gene2924 5.435e-62 226.0 2CAZH@1|root,2Z7RU@2|Bacteria,2NRIS@2323|unclassified Bacteria 2|Bacteria - - sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt CMS2_k127_6551281_21 1183438.GKIL_2277 1.163e-19 94.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4440,SnoaL_2,SnoaL_4 CMS2_k127_6551281_17 502025.Hoch_1959 8.382e-31 128.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,4316A@68525|delta/epsilon subdivisions,2WX34@28221|Deltaproteobacteria 28221|Deltaproteobacteria J S4 RNA-binding domain - - - ko:K04762 - - - - ko00000,ko03110 - - - S4 CMS2_k127_6551281_8 1121405.dsmv_0956 2.605e-89 308.0 COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,42SUF@68525|delta/epsilon subdivisions,2WPJU@28221|Deltaproteobacteria,2MKU8@213118|Desulfobacterales 28221|Deltaproteobacteria E Ornithine cyclodeaminase/mu-crystallin family - - 1.4.1.1,4.3.1.12 ko:K01750,ko:K19244 ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230 - R00396,R00671 RC00008,RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall CMS2_k127_6551281_4 266117.Rxyl_0056 4.742e-162 516.0 COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4CPC1@84995|Rubrobacteria 84995|Rubrobacteria S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N CMS2_k127_6551281_9 589865.DaAHT2_1592 4.473e-77 265.0 COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,42S19@68525|delta/epsilon subdivisions,2WNGU@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 CMS2_k127_6551281_13 1267533.KB906734_gene3730 6.764e-56 201.0 2AYX9@1|root,31R2Z@2|Bacteria,3Y4ZH@57723|Acidobacteria,2JJGK@204432|Acidobacteriia 204432|Acidobacteriia S DinB superfamily - - - - - - - - - - - - DinB_2 CMS2_k127_6551281_1 452637.Oter_0373 1.153e-199 631.0 COG1509@1|root,COG1509@2|Bacteria 2|Bacteria E lysine 2,3-aminomutase activity kamA3 - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM CMS2_k127_6551281_12 868595.Desca_0490 8.32e-58 217.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,260IY@186807|Peptococcaceae 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N CMS2_k127_6551281_18 1207076.ALAT01000174_gene2065 9.437e-31 125.0 2DNJV@1|root,32UJ6@2|Bacteria,1N4SS@1224|Proteobacteria,1SQYW@1236|Gammaproteobacteria,1Z47D@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6551281_16 511.JT27_09905 5.636e-39 154.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,3T1CP@506|Alcaligenaceae 28216|Betaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase CMS2_k127_6551281_15 204669.Acid345_1386 5.054e-42 160.0 2EDAV@1|root,33776@2|Bacteria,3Y8RG@57723|Acidobacteria,2JNHN@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - CMS2_k127_6551281_19 861299.J421_0895 9.682e-28 123.0 COG0705@1|root,COG0705@2|Bacteria,1ZSWV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Rhomboid family - - - - - - - - - - - - Rhomboid CMS2_k127_6555380_0 313596.RB2501_12302 3.462e-253 801.0 COG2091@1|root,COG2091@2|Bacteria,4NGXG@976|Bacteroidetes,1HZ27@117743|Flavobacteriia 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_6555380_1 929556.Solca_2459 5.336e-97 333.0 COG5368@1|root,COG5368@2|Bacteria,4NJHP@976|Bacteroidetes 976|Bacteroidetes G Hydrolase Family 16 - - - - - - - - - - - - - CMS2_k127_6555380_3 1047013.AQSP01000097_gene1954 5.467e-16 83.0 COG1895@1|root,COG1895@2|Bacteria,2NRN4@2323|unclassified Bacteria 2|Bacteria S HEPN domain - - - - - - - - - - - - HEPN CMS2_k127_6555380_2 1396858.Q666_03740 2.202e-30 128.0 COG1708@1|root,COG1708@2|Bacteria,1RCAH@1224|Proteobacteria,1S3KC@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional - - - - - - - - - - - - MarR_2,NTP_transf_2 CMS2_k127_6565960_5 391625.PPSIR1_04008 8.025e-95 325.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42NUP@68525|delta/epsilon subdivisions,2WKSD@28221|Deltaproteobacteria,2Z2YE@29|Myxococcales 28221|Deltaproteobacteria M Mechanosensitive ion channel mscS-1 - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel CMS2_k127_6565960_16 1047013.AQSP01000097_gene1952 0.000791 51.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,TolB_like CMS2_k127_6565960_15 1340493.JNIF01000004_gene1025 1.357e-07 57.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - ko:K07004 - - - - ko00000 - - - PKD,PPC,Peptidase_M10,Peptidase_M28,SLH CMS2_k127_6565960_2 1502850.FG91_01562 1.817e-132 436.0 COG1835@1|root,COG1835@2|Bacteria,1PVUR@1224|Proteobacteria,2TTRB@28211|Alphaproteobacteria,2K98C@204457|Sphingomonadales 204457|Sphingomonadales I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 CMS2_k127_6565960_7 596151.DesfrDRAFT_2034 2.148e-73 261.0 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2WKUD@28221|Deltaproteobacteria,2M8FS@213115|Desulfovibrionales 28221|Deltaproteobacteria S CBS domain containing protein - - - - - - - - - - - - CBS,DUF21 CMS2_k127_6565960_11 234267.Acid_4721 9.232e-23 101.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR CMS2_k127_6565960_1 251221.35211765 1.172e-179 595.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_6565960_10 313603.FB2170_14803 9.311e-54 204.0 COG1142@1|root,COG1142@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - Fer4_10,Fer4_7,Fer4_9,Pyr_redox_2,Pyr_redox_3,cNMP_binding CMS2_k127_6565960_4 945713.IALB_0801 3.378e-101 348.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7 CMS2_k127_6565960_6 1408473.JHXO01000005_gene1865 1.512e-76 269.0 COG0484@1|root,COG0484@2|Bacteria,4NPS0@976|Bacteroidetes,2FXKU@200643|Bacteroidia 976|Bacteroidetes O heat shock protein binding - - - - - - - - - - - - - CMS2_k127_6565960_3 1245469.S58_30880 9.488e-124 413.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PR9I@1224|Proteobacteria,2U1SM@28211|Alphaproteobacteria 28211|Alphaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_4,Fer4_6,Pyr_redox_3 CMS2_k127_6565960_0 1123242.JH636435_gene2470 1.64e-217 686.0 COG0578@1|root,COG0578@2|Bacteria,2IX2V@203682|Planctomycetes 203682|Planctomycetes C Glycerol-3-phosphate dehydrogenase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C CMS2_k127_6565960_8 1137799.GZ78_07870 2.618e-63 224.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1XJ7K@135619|Oceanospirillales 135619|Oceanospirillales T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg CMS2_k127_6565960_9 472759.Nhal_3532 3.259e-58 225.0 COG2202@1|root,COG2203@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase fixL - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg CMS2_k127_6565960_12 552811.Dehly_0411 3.831e-15 81.0 COG0680@1|root,COG0680@2|Bacteria,2G7BV@200795|Chloroflexi,34D7G@301297|Dehalococcoidia 301297|Dehalococcoidia C Hydrogenase maturation protease - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI CMS2_k127_6565960_14 391623.TERMP_00067 6.949e-09 61.0 COG1145@1|root,arCOG05128@2157|Archaea,2XY2U@28890|Euryarchaeota,242VZ@183968|Thermococci 183968|Thermococci C 4Fe-4S dicluster domain - - 1.12.98.4 ko:K17996 ko00920,map00920 - R10390 - ko00000,ko00001,ko01000 - - - Fer4_22 CMS2_k127_6565960_13 335543.Sfum_2366 2.221e-11 67.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ88@28221|Deltaproteobacteria,2MS3K@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS2_k127_6606550_2 382464.ABSI01000014_gene1483 1.443e-147 480.0 COG1538@1|root,COG1538@2|Bacteria,46WHQ@74201|Verrucomicrobia,2IW13@203494|Verrucomicrobiae 203494|Verrucomicrobiae MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS2_k127_6606550_1 382464.ABSI01000005_gene973 2.404e-221 703.0 COG0845@1|root,COG0845@2|Bacteria,46SVD@74201|Verrucomicrobia,2IUGZ@203494|Verrucomicrobiae 203494|Verrucomicrobiae M Protein of unknown function (DUF3347) - - - - - - - - - - - - DUF3347,HlyD_D23 CMS2_k127_6606550_0 382464.ABSI01000011_gene2351 0.0 2018.0 COG0841@1|root,COG0841@2|Bacteria,46Z6Y@74201|Verrucomicrobia,2ITZB@203494|Verrucomicrobiae 203494|Verrucomicrobiae V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran CMS2_k127_6606550_3 382464.ABSI01000014_gene1489 5.44e-26 117.0 COG0845@1|root,COG0845@2|Bacteria,46WQR@74201|Verrucomicrobia 74201|Verrucomicrobia M Protein of unknown function (DUF3347) - - - - - - - - - - - - DUF3347 CMS2_k127_6622454_10 861299.J421_1545 2.278e-06 57.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD CMS2_k127_6622454_3 861299.J421_3530 2.054e-145 495.0 COG1629@1|root,COG4771@2|Bacteria,1ZST4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P CarboxypepD_reg-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec CMS2_k127_6622454_1 1244869.H261_06576 1.669e-201 647.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales 204441|Rhodospirillales C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM CMS2_k127_6622454_5 1340493.JNIF01000003_gene1551 9.351e-43 164.0 COG2318@1|root,COG2318@2|Bacteria,3Y503@57723|Acidobacteria 57723|Acidobacteria S DinB family - - - - - - - - - - - - DinB_2 CMS2_k127_6622454_6 342949.PNA2_1768 1.8e-40 157.0 COG0819@1|root,arCOG01128@2157|Archaea,2Y6B2@28890|Euryarchaeota,243SP@183968|Thermococci 183968|Thermococci K TENA/THI-4/PQQC family - - - ko:K20896 ko00730,ko01100,map00730,map01100 - R09993,R11313 RC00197,RC02832 ko00000,ko00001,ko01000 - - - TENA_THI-4 CMS2_k127_6622454_8 1123073.KB899241_gene2834 1.331e-24 107.0 COG0596@1|root,COG0596@2|Bacteria,1QVBQ@1224|Proteobacteria,1T2BH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - - CMS2_k127_6622454_4 479434.Sthe_2734 3.198e-48 180.0 COG5516@1|root,COG5516@2|Bacteria,2G7GV@200795|Chloroflexi 200795|Chloroflexi S Putative stress-induced transcription regulator - - - - - - - - - - - - ABATE,zf-CGNR CMS2_k127_6622454_7 1197906.CAJQ02000047_gene4077 6.365e-35 136.0 COG2329@1|root,COG2329@2|Bacteria,1N2ZS@1224|Proteobacteria,2UEPY@28211|Alphaproteobacteria,3K08M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - - CMS2_k127_6622454_2 1267535.KB906767_gene4657 5.472e-146 478.0 COG3852@1|root,COG3852@2|Bacteria,3Y3JR@57723|Acidobacteria,2JIY1@204432|Acidobacteriia 204432|Acidobacteriia T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HATPase_c,cNMP_binding CMS2_k127_6622454_0 111781.Lepto7376_3836 3.03e-211 670.0 COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1HH7U@1150|Oscillatoriales 1117|Cyanobacteria KOT PFAM Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Response_reg CMS2_k127_6622454_9 875328.JDM601_1006 2.426e-20 93.0 COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase type 11 - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 CMS2_k127_6644612_0 1047013.AQSP01000134_gene1353 0.0 1109.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 CMS2_k127_6644612_1 1379270.AUXF01000004_gene3290 2.29e-194 635.0 COG0457@1|root,COG0457@2|Bacteria,1ZU8U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 CMS2_k127_6644612_2 653733.Selin_0567 9.374e-129 445.0 COG0348@1|root,COG1622@1|root,COG0348@2|Bacteria,COG1622@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor vnfA - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1,Fer4_5,Sigma54_activat,cNMP_binding CMS2_k127_6644612_4 1144319.PMI16_00807 1.104e-08 61.0 COG1622@1|root,COG1622@2|Bacteria,1NEC9@1224|Proteobacteria,2VWA0@28216|Betaproteobacteria,477JR@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cupredoxin-like domain - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1 CMS2_k127_6644612_3 861299.J421_4337 1.221e-47 180.0 COG2010@1|root,COG2010@2|Bacteria,1ZUYW@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 CMS2_k127_6664974_4 511062.GU3_06185 7.603e-09 66.0 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,1T3AY@1236|Gammaproteobacteria,1Y51I@135624|Aeromonadales 135624|Aeromonadales U Domain of unknown function (DUF4347) - - - - - - - - - - - - DUF4347 CMS2_k127_6664974_3 445335.CBN_0137 3.027e-09 70.0 COG0769@1|root,COG1181@1|root,COG0769@2|Bacteria,COG1181@2|Bacteria,1UJ6D@1239|Firmicutes,25EWC@186801|Clostridia,36USG@31979|Clostridiaceae 186801|Clostridia M Belongs to the MurCDEF family cphA - 6.3.2.2,6.3.2.29,6.3.2.30 ko:K01919,ko:K03802 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M,RimK CMS2_k127_6664974_0 518766.Rmar_1177 2.297e-166 540.0 COG0626@1|root,COG0626@2|Bacteria,4NF0Q@976|Bacteroidetes,1FJQ4@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E PFAM Cys Met metabolism pyridoxal-phosphate- dependent protein - - 2.5.1.48,4.4.1.1,4.4.1.11 ko:K01739,ko:K01758,ko:K01761 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00654,R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP CMS2_k127_6664974_2 861299.J421_3625 1.219e-38 150.0 COG3118@1|root,COG3118@2|Bacteria,1ZV4B@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Thioredoxin-like domain - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin CMS2_k127_6664974_1 1340493.JNIF01000003_gene4071 1.937e-159 514.0 COG0520@1|root,COG0520@2|Bacteria,3Y4TH@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 CMS2_k127_6710906_11 913865.DOT_5128 1.716e-06 55.0 COG5561@1|root,COG5561@2|Bacteria,1VBTY@1239|Firmicutes,24Q06@186801|Clostridia,2654V@186807|Peptococcaceae 186801|Clostridia S CGGC - - - - - - - - - - - - CGGC CMS2_k127_6710906_3 1265505.ATUG01000001_gene2868 3.161e-196 623.0 COG1055@1|root,COG1055@2|Bacteria,1QUC0@1224|Proteobacteria,42NUZ@68525|delta/epsilon subdivisions,2WJNH@28221|Deltaproteobacteria,2MPNS@213118|Desulfobacterales 28221|Deltaproteobacteria P Sodium:sulfate symporter transmembrane region - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp CMS2_k127_6710906_4 1047013.AQSP01000110_gene79 2.717e-153 501.0 COG0733@1|root,COG0733@2|Bacteria,2NQIH@2323|unclassified Bacteria 2|Bacteria S Sodium:neurotransmitter symporter family CP_0468 - - ko:K03308,ko:K03466 - - - - ko00000,ko03036 2.A.22.4,2.A.22.5,3.A.12 - - SNF CMS2_k127_6710906_7 861299.J421_3991 2.679e-42 165.0 29F5I@1|root,30238@2|Bacteria,1ZU4C@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_6710906_9 298654.FraEuI1c_4263 4.402e-11 76.0 COG2909@1|root,COG2909@2|Bacteria,2GJIA@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - AAA_16,GerE,TPR_12 CMS2_k127_6710906_6 861299.J421_6034 1.239e-45 188.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C CMS2_k127_6710906_8 1318628.MARLIPOL_14455 4.626e-41 165.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg CMS2_k127_6710906_5 234267.Acid_1085 1.5e-94 320.0 COG0123@1|root,COG0123@2|Bacteria,3Y46F@57723|Acidobacteria 57723|Acidobacteria BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl CMS2_k127_6710906_1 1340493.JNIF01000004_gene652 3.86e-244 769.0 COG2274@1|root,COG2274@2|Bacteria 2|Bacteria V protein secretion by the type I secretion system - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran CMS2_k127_6710906_0 861299.J421_1753 0.0 1135.0 COG0446@1|root,COG4888@1|root,COG0446@2|Bacteria,COG4888@2|Bacteria 2|Bacteria G ASPIC UnbV domain protein - - - - - - - - - - - - FG-GAP,Pyr_redox_2,UnbV_ASPIC,VCBS CMS2_k127_6710906_2 1379270.AUXF01000002_gene1134 1.081e-202 655.0 COG2091@1|root,COG2091@2|Bacteria,1ZU9H@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - CMS2_k127_6710906_10 861299.J421_1280 2.689e-07 63.0 COG0515@1|root,COG3629@1|root,COG0515@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 2|Bacteria T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS2_k127_6723568_0 1121930.AQXG01000010_gene3060 5.403e-157 506.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IR3P@117747|Sphingobacteriia 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ CMS2_k127_6723568_1 756067.MicvaDRAFT_1008 5.319e-67 237.0 COG0400@1|root,COG0400@2|Bacteria,1G3RX@1117|Cyanobacteria 1117|Cyanobacteria S PFAM phospholipase Carboxylesterase - - - - - - - - - - - - Abhydrolase_2,Esterase CMS2_k127_6723568_2 204669.Acid345_2503 4.533e-05 55.0 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) VPA0557 - - - - - - - - - - - DUF4292,LolA_like CMS2_k127_6736229_3 309807.SRU_2711 1.43e-205 668.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,4NEW6@976|Bacteroidetes,1FJJN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes CO Disulphide bond corrector protein DsbC - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 CMS2_k127_6736229_5 797114.C475_02583 1.445e-56 205.0 COG0500@1|root,arCOG04734@2157|Archaea,2XWDH@28890|Euryarchaeota,23V0A@183963|Halobacteria 183963|Halobacteria Q COG0500 SAM-dependent methyltransferases - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 CMS2_k127_6736229_6 1096769.Pelub83DRAFT_0415 7.569e-23 98.0 2FDFA@1|root,345GY@2|Bacteria,1P1RR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_6736229_7 240015.ACP_1650 2.236e-22 102.0 COG1487@1|root,COG1487@2|Bacteria,3Y8P9@57723|Acidobacteria 57723|Acidobacteria S ribonuclease activity - - - - - - - - - - - - - CMS2_k127_6736229_10 472759.Nhal_0171 1.172e-07 59.0 2E9N9@1|root,333US@2|Bacteria,1NBXS@1224|Proteobacteria,1SVGF@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Ribbon-helix-helix protein, copG family - - - - - - - - - - - - RHH_1 CMS2_k127_6736229_1 929562.Emtol_2704 4.156e-312 975.0 COG1554@1|root,COG1554@2|Bacteria,4NEWW@976|Bacteroidetes,47JFT@768503|Cytophagia 976|Bacteroidetes G Glycosyl hydrolase family 65, N-terminal domain - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2 CMS2_k127_6736229_9 1132441.KI519454_gene1474 1.193e-21 96.0 COG1476@1|root,COG1476@2|Bacteria,2GQIU@201174|Actinobacteria,1WA2Z@1268|Micrococcaceae 201174|Actinobacteria K Helix-turn-helix XRE-family like proteins - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 CMS2_k127_6736229_11 660470.Theba_2634 0.0001997 51.0 COG1305@1|root,COG1305@2|Bacteria,2GC1R@200918|Thermotogae 2|Bacteria E transglutaminase domain protein - - - - - - - - - - - - TIG,Transglut_core CMS2_k127_6736229_0 518766.Rmar_0089 0.0 1074.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_6736229_4 452637.Oter_2609 4.674e-197 629.0 COG0591@1|root,COG0591@2|Bacteria,46UEN@74201|Verrucomicrobia,3K9NP@414999|Opitutae 414999|Opitutae E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF CMS2_k127_6736229_2 452637.Oter_2611 7.135e-247 792.0 COG2120@1|root,COG2120@2|Bacteria,46UF1@74201|Verrucomicrobia 74201|Verrucomicrobia S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L CMS2_k127_6736229_8 861299.J421_1517 1.076e-21 104.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_1517|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_6739523_1 379066.GAU_1023 1.28e-34 149.0 COG3121@1|root,COG3121@2|Bacteria 2|Bacteria NU pilus organization - - - - - - - - - - - - ASH,AhpC-TSA,Calx-beta,HemolysinCabind,LVIVD,PPC,PapD_N,Peptidase_S8 CMS2_k127_6739523_2 1120966.AUBU01000015_gene1869 3.193e-34 153.0 COG3188@1|root,COG3188@2|Bacteria,4NFPY@976|Bacteroidetes 976|Bacteroidetes NU N-Acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - - CMS2_k127_6739523_0 379066.GAU_1412 9.124e-57 228.0 COG0457@1|root,COG0457@2|Bacteria,1ZSPN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388,TPR_16,TPR_2 CMS2_k127_6783343_11 335543.Sfum_1623 1.005e-12 72.0 COG3118@1|root,COG3118@2|Bacteria,1PQ8G@1224|Proteobacteria 1224|Proteobacteria O ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS CMS2_k127_6783343_0 357808.RoseRS_2067 3.196e-224 714.0 COG1620@1|root,COG1620@2|Bacteria,2G6VR@200795|Chloroflexi 200795|Chloroflexi C L-lactate permease - - - ko:K03303 - - - - ko00000,ko02000 2.A.14 - - Lactate_perm CMS2_k127_6783343_9 926550.CLDAP_10760 9.919e-44 170.0 COG1556@1|root,COG1556@2|Bacteria,2G7BK@200795|Chloroflexi 200795|Chloroflexi S LUD domain - - - ko:K00782 - - - - ko00000 - - - LUD_dom CMS2_k127_6783343_1 926550.CLDAP_00040 4.97e-167 537.0 COG1139@1|root,COG1139@2|Bacteria,2G665@200795|Chloroflexi 200795|Chloroflexi C Iron-sulfur cluster binding protein - - - ko:K18929 - - - - ko00000 - - - CCG,DUF3390,Fer4_7,Fer4_8,LUD_dom CMS2_k127_6783343_5 1463881.KL591008_gene1952 2.254e-67 242.0 COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria 201174|Actinobacteria C Fe-S oxidoreductase - - - ko:K18928 - - - - ko00000 - - - CCG CMS2_k127_6783343_3 857293.CAAU_2006 4.854e-137 462.0 COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,36E8E@31979|Clostridiaceae 186801|Clostridia C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS2_k127_6783343_10 1267535.KB906767_gene551 1.1e-43 177.0 COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,3Y5RE@57723|Acidobacteria 57723|Acidobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - DmsC,Fer4_11 CMS2_k127_6783343_7 357808.RoseRS_0493 1.299e-65 241.0 COG1651@1|root,COG4243@1|root,COG1651@2|Bacteria,COG4243@2|Bacteria,2G9QC@200795|Chloroflexi,3764Y@32061|Chloroflexia 32061|Chloroflexia CO PFAM Vitamin K epoxide reductase - - - - - - - - - - - - VKOR CMS2_k127_6783343_8 1121438.JNJA01000009_gene4185 2.841e-46 173.0 COG0500@1|root,COG2226@2|Bacteria,1N3WC@1224|Proteobacteria,42URQ@68525|delta/epsilon subdivisions,2WQGW@28221|Deltaproteobacteria,2MCVU@213115|Desulfovibrionales 28221|Deltaproteobacteria Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 CMS2_k127_6783343_4 1379270.AUXF01000007_gene915 1.001e-67 248.0 2CESB@1|root,2Z8UZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_6783343_6 666685.R2APBS1_2137 4.362e-67 237.0 COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,1S1WW@1236|Gammaproteobacteria,1XD2G@135614|Xanthomonadales 135614|Xanthomonadales S Conserved hypothetical protein (DUF2461) - - - - - - - - - - - - DUF2461 CMS2_k127_6783343_2 251221.35211765 1.093e-162 541.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_680109_0 1121918.ARWE01000001_gene2503 4.823e-52 187.0 COG0450@1|root,COG0450@2|Bacteria,1MYZG@1224|Proteobacteria,42SNG@68525|delta/epsilon subdivisions,2WP3M@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA CMS2_k127_680109_5 589865.DaAHT2_2091 5.486e-15 76.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2WNIG@28221|Deltaproteobacteria,2MJSH@213118|Desulfobacterales 28221|Deltaproteobacteria O AhpC/TSA family - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA CMS2_k127_680109_3 706587.Desti_0283 2.247e-26 113.0 COG0745@1|root,COG0745@2|Bacteria,1NBQZ@1224|Proteobacteria,42V8P@68525|delta/epsilon subdivisions,2WS87@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - Response_reg CMS2_k127_680109_7 760192.Halhy_4493 1.897e-07 60.0 2DMID@1|root,32RSF@2|Bacteria,4PP1U@976|Bacteroidetes,1J0XI@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DUF2204 CMS2_k127_680109_4 861299.J421_4365 1.776e-17 95.0 2EY2H@1|root,33RBE@2|Bacteria,1ZTHK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_680109_2 28564.XP_002486819.1 2.189e-32 145.0 COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3NXT8@4751|Fungi,3RDUS@4890|Ascomycota,20NAJ@147545|Eurotiomycetes,3SBCW@5042|Eurotiales 4751|Fungi M Ankyrin repeat - - - - - - - - - - - - Ank,Ank_2,Ank_4,Ank_5,F-box-like,SPRY CMS2_k127_680109_1 861299.J421_4495 3.443e-42 171.0 COG4219@1|root,COG4219@2|Bacteria,1ZUY4@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT BlaR1 peptidase M56 - - - - - - - - - - - - Peptidase_M56,TonB_C CMS2_k127_6875551_10 1128421.JAGA01000002_gene1500 1.52e-36 139.0 COG1146@1|root,COG1146@2|Bacteria,2NPWS@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain fdxA - - - - - - - - - - - Fer4,Fer4_4,Fer4_7 CMS2_k127_6875551_8 1223410.KN050846_gene1890 1.33e-46 172.0 28NYH@1|root,2ZBVN@2|Bacteria,4NMB2@976|Bacteroidetes,1I177@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the UPF0403 family yqiW - - - - - - - - - - - Disulph_isomer CMS2_k127_6875551_7 861299.J421_3529 3.146e-49 184.0 COG0584@1|root,COG0584@2|Bacteria,1ZTMT@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD CMS2_k127_6875551_3 105559.Nwat_0941 6.198e-181 576.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RZ0N@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH CMS2_k127_6875551_14 383372.Rcas_2148 5.285e-18 94.0 COG0745@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg CMS2_k127_6875551_0 502025.Hoch_1780 1.561e-308 963.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,2YUAP@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N CMS2_k127_6875551_11 404589.Anae109_0423 1.768e-35 141.0 COG2062@1|root,COG2062@2|Bacteria,1PKQQ@1224|Proteobacteria,43AAX@68525|delta/epsilon subdivisions,2WYNV@28221|Deltaproteobacteria,2Z26S@29|Myxococcales 28221|Deltaproteobacteria T Phosphoglycerate mutase family - - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 CMS2_k127_6875551_13 161528.ED21_20779 4.714e-27 124.0 2FGC9@1|root,3488G@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 CMS2_k127_6875551_9 290315.Clim_0819 4.74e-38 154.0 COG3204@1|root,COG3204@2|Bacteria,1FEUK@1090|Chlorobi 1090|Chlorobi S SdiA-regulated - - - - - - - - - - - - SdiA-regulated CMS2_k127_6875551_4 1123073.KB899242_gene1496 1.045e-154 504.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1X46J@135614|Xanthomonadales 135614|Xanthomonadales FP Belongs to the GppA Ppx family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA CMS2_k127_6875551_1 404589.Anae109_3731 7.874e-193 633.0 COG4775@1|root,COG4775@2|Bacteria 2|Bacteria M membrane organization - - - - - - - - - - - - Bac_surface_Ag,CarboxypepD_reg,Laminin_G_3,POTRA CMS2_k127_6875551_12 861299.J421_3996 4.051e-32 139.0 COG2954@1|root,COG5607@1|root,COG2954@2|Bacteria,COG5607@2|Bacteria,1ZTYF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S CYTH - - - - - - - - - - - - CHAD CMS2_k127_6875551_2 880073.Calab_2889 4.444e-187 608.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NQIQ@2323|unclassified Bacteria 2|Bacteria E X-Pro dipeptidyl-peptidase (S15 family) dpp - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 CMS2_k127_6875551_6 1047013.AQSP01000067_gene2204 4.128e-100 340.0 COG0436@1|root,COG0436@2|Bacteria,2NR19@2323|unclassified Bacteria 2|Bacteria E Aminotransferase class-V - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_6875551_5 293826.Amet_4112 5.702e-136 443.0 COG0031@1|root,COG0031@2|Bacteria,1UZEQ@1239|Firmicutes,24BCR@186801|Clostridia,36G6F@31979|Clostridiaceae 186801|Clostridia E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_6875551_15 379066.GAU_0620 1.065e-05 52.0 COG0526@1|root,COG0526@2|Bacteria,1ZTMM@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Glutathione peroxidase - - - - - - - - - - - - AhpC-TSA CMS2_k127_6877021_9 1379270.AUXF01000004_gene3324 5.083e-107 358.0 COG4584@1|root,COG4584@2|Bacteria,1ZV8R@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Integrase core domain - - - - - - - - - - - - rve CMS2_k127_6877021_8 1379270.AUXF01000004_gene3323 6.044e-115 376.0 COG1484@1|root,COG1484@2|Bacteria,1ZV5D@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bacterial dnaA protein - - - - - - - - - - - - IstB_IS21 CMS2_k127_6877021_12 258052.JNYV01000007_gene2906 1.877e-40 167.0 COG0637@1|root,COG0637@2|Bacteria,2I362@201174|Actinobacteria 201174|Actinobacteria S hydrolase - - - - - - - - - - - - HAD_2 CMS2_k127_6877021_3 595460.RRSWK_02092 3.618e-257 804.0 COG1069@1|root,COG1069@2|Bacteria,2IY2X@203682|Planctomycetes 203682|Planctomycetes G FGGY family of carbohydrate kinases, N-terminal domain araB - 2.7.1.16 ko:K00853 ko00040,ko01100,map00040,map01100 - R01526,R02439 RC00002,RC00538 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N CMS2_k127_6877021_10 595460.RRSWK_02093 1.338e-91 306.0 COG0235@1|root,COG0235@2|Bacteria,2J0EX@203682|Planctomycetes 203682|Planctomycetes G Class II Aldolase and Adducin N-terminal domain - - 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II CMS2_k127_6877021_4 1128421.JAGA01000001_gene2416 1.406e-224 705.0 COG2160@1|root,COG2160@2|Bacteria 2|Bacteria G L-arabinose isomerase activity araA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1922,iB21_1397.B21_00063,iBWG_1329.BWG_0058,iE2348C_1286.E2348C_0063,iECBD_1354.ECBD_3555,iECD_1391.ECD_00064,iECED1_1282.ECED1_0061,iECIAI1_1343.ECIAI1_0062,iECNA114_1301.ECNA114_0050,iECO103_1326.ECO103_0063,iECO26_1355.ECO26_0064,iECOK1_1307.ECOK1_0061,iECP_1309.ECP_0063,iECS88_1305.ECS88_0065,iECSE_1348.ECSE_0062,iECW_1372.ECW_m0060,iEKO11_1354.EKO11_3852,iEcE24377_1341.EcE24377A_0064,iEcHS_1320.EcHS_A0066,iEcSMS35_1347.EcSMS35_0064,iEcolC_1368.EcolC_3595,iLF82_1304.LF82_0105,iLJ478.TM0276,iNRG857_1313.NRG857_00320,iSBO_1134.SBO_0049,iSSON_1240.SSON_0068,iUMN146_1321.UM146_23095,iUTI89_1310.UTI89_C0067,iWFL_1372.ECW_m0060 Arabinose_Iso_C,Arabinose_Isome CMS2_k127_6877021_1 595460.RRSWK_02095 7.263e-299 925.0 COG4146@1|root,COG4146@2|Bacteria,2J29I@203682|Planctomycetes 203682|Planctomycetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF CMS2_k127_6877021_0 1270196.JCKI01000002_gene7 0.0 1086.0 2CDRA@1|root,2Z7QN@2|Bacteria,4NHVB@976|Bacteroidetes,1IQJV@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_6877021_7 765911.Thivi_3898 1.907e-131 431.0 COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,1RQVD@1236|Gammaproteobacteria,1WXGB@135613|Chromatiales 135613|Chromatiales P Citrate transporter - - - - - - - - - - - - CitMHS CMS2_k127_6877021_2 682795.AciX8_4155 1.2e-267 853.0 COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia 204432|Acidobacteriia S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 CMS2_k127_6877021_11 504472.Slin_5488 2.861e-49 188.0 COG1082@1|root,COG1082@2|Bacteria,4NGKX@976|Bacteroidetes,47JP9@768503|Cytophagia 976|Bacteroidetes G Xylose isomerase domain protein TIM barrel - - - - - - - - - - - - AP_endonuc_2 CMS2_k127_6877021_5 927658.AJUM01000034_gene436 1.174e-171 554.0 COG1262@1|root,COG3005@1|root,COG1262@2|Bacteria,COG3005@2|Bacteria,4NEUZ@976|Bacteroidetes,2G2PJ@200643|Bacteroidia,3XM0I@558415|Marinilabiliaceae 976|Bacteroidetes C Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - Cytochrom_NNT,FGE-sulfatase CMS2_k127_6877021_6 927658.AJUM01000034_gene437 8.543e-160 516.0 COG0673@1|root,COG0673@2|Bacteria,4NF9M@976|Bacteroidetes,2FMQW@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,TAT_signal CMS2_k127_6877021_14 326427.Cagg_1682 5.351e-20 94.0 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity MA20_23570 - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_34 CMS2_k127_6877021_13 706587.Desti_1873 3.511e-35 148.0 COG1453@1|root,COG1453@2|Bacteria,1RAU3@1224|Proteobacteria,43A0M@68525|delta/epsilon subdivisions,2X9UN@28221|Deltaproteobacteria,2MS7U@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM aldo keto reductase - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red CMS2_k127_6877021_15 644281.MFS40622_0774 2.63e-09 61.0 arCOG13418@1|root,arCOG13418@2157|Archaea,2Y5VK@28890|Euryarchaeota 28890|Euryarchaeota - - - - - - - - - - - - - - - CMS2_k127_6886956_4 926550.CLDAP_18550 3.821e-213 676.0 COG1001@1|root,COG1001@2|Bacteria,2G64P@200795|Chloroflexi 200795|Chloroflexi F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 CMS2_k127_6886956_30 1121405.dsmv_0022 4.591e-20 95.0 COG1433@1|root,COG1433@2|Bacteria,1N56C@1224|Proteobacteria,42TK7@68525|delta/epsilon subdivisions,2WQ0G@28221|Deltaproteobacteria,2MKGU@213118|Desulfobacterales 28221|Deltaproteobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co CMS2_k127_6886956_33 1408439.JHXW01000011_gene183 1.428e-12 73.0 COG1342@1|root,COG1433@1|root,COG1342@2|Bacteria,COG1433@2|Bacteria,37AEX@32066|Fusobacteria 32066|Fusobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co CMS2_k127_6886956_23 290397.Adeh_0133 3.339e-74 265.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WNXT@28221|Deltaproteobacteria,2YV4W@29|Myxococcales 28221|Deltaproteobacteria EGP of the major facilitator superfamily agmP - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1,MFS_1_like,Sugar_tr CMS2_k127_6886956_0 861299.J421_1048 4.317e-240 774.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_6886956_15 439235.Dalk_3688 2.157e-113 377.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42M1K@68525|delta/epsilon subdivisions,2WJ8E@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM peptidase M24 - - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C CMS2_k127_6886956_1 1379270.AUXF01000004_gene2897 2.241e-236 757.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec CMS2_k127_6886956_10 1123253.AUBD01000007_gene706 7.917e-124 404.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,1X4PF@135614|Xanthomonadales 135614|Xanthomonadales I fatty acid desaturase desC - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase CMS2_k127_6886956_9 330214.NIDE0210 6.025e-141 462.0 COG2907@1|root,COG2907@2|Bacteria 2|Bacteria S Flavin containing amine oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 CMS2_k127_6886956_20 330214.NIDE0211 1.312e-99 332.0 COG3496@1|root,COG3496@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1365) - - 2.1.1.79 ko:K00574,ko:K09701 - - - - ko00000,ko01000 - - - DUF1365 CMS2_k127_6886956_8 472759.Nhal_0313 2.309e-141 459.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WX07@135613|Chromatiales 135613|Chromatiales M PFAM Cyclopropane-fatty-acyl-phospholipid synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS CMS2_k127_6886956_22 344747.PM8797T_03384 6.733e-80 275.0 COG3752@1|root,COG3752@2|Bacteria,2IZ0I@203682|Planctomycetes 203682|Planctomycetes S 3-oxo-5-alpha-steroid 4-dehydrogenase - - - - - - - - - - - - DUF1295 CMS2_k127_6886956_13 1177179.A11A3_01717 8.162e-116 384.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1XIAF@135619|Oceanospirillales 135619|Oceanospirillales M Cyclopropane fatty acid synthase and related - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS CMS2_k127_6886956_24 945713.IALB_2287 1.209e-40 158.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_6886956_19 1254432.SCE1572_42005 5.396e-101 345.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales 28221|Deltaproteobacteria K acetyltransferase - - - - - - - - - - - - - CMS2_k127_6886956_5 472759.Nhal_3602 4.796e-194 609.0 COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C7@1236|Gammaproteobacteria,1X2MB@135613|Chromatiales 135613|Chromatiales O Radical SAM superfamily - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM CMS2_k127_6886956_16 1121930.AQXG01000004_gene2861 8.323e-110 372.0 COG2234@1|root,COG2234@2|Bacteria,4NEHY@976|Bacteroidetes,1IP78@117747|Sphingobacteriia 976|Bacteroidetes S Peptidase, M28 - - - - - - - - - - - - Peptidase_M28 CMS2_k127_6886956_7 880073.Calab_2466 5.102e-143 464.0 COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria 2|Bacteria S ATPase associated with various cellular moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS2_k127_6886956_14 880073.Calab_2467 9.338e-114 373.0 COG1721@1|root,COG1721@2|Bacteria,2NNQI@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - - - - - - - - - - DUF58 CMS2_k127_6886956_28 1379698.RBG1_1C00001G1776 1.273e-26 124.0 COG3088@1|root,COG3088@2|Bacteria,2NS4V@2323|unclassified Bacteria 2|Bacteria O subunit of a heme lyase ccmH GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:1901564 - ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018 - - R05712 RC00176 ko00000,ko02000 9.B.14.1 - - CcmH CMS2_k127_6886956_12 880073.Calab_2474 4.809e-116 383.0 COG2304@1|root,COG2304@2|Bacteria,2NNYH@2323|unclassified Bacteria 2|Bacteria NU von Willebrand factor (vWF) type A domain batA - - ko:K07114,ko:K12511 - - - - ko00000,ko02000,ko02044 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA CMS2_k127_6886956_21 880073.Calab_2475 1.861e-84 291.0 COG2304@1|root,COG2304@2|Bacteria,2NP2F@2323|unclassified Bacteria 2|Bacteria S von Willebrand factor (vWF) type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 CMS2_k127_6886956_31 1379698.RBG1_1C00001G1774 1.665e-14 83.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2NP2F@2323|unclassified Bacteria 2|Bacteria S von Willebrand factor (vWF) type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 CMS2_k127_6886956_17 880073.Calab_2478 2.635e-107 371.0 COG0457@1|root,COG0457@2|Bacteria,2NP5J@2323|unclassified Bacteria 2|Bacteria S Oxygen tolerance - - - - - - - - - - - - BatD CMS2_k127_6886956_25 1501391.LG35_05925 1.341e-38 154.0 COG0457@1|root,COG0457@2|Bacteria,4NF5V@976|Bacteroidetes,2FP54@200643|Bacteroidia,22V8H@171550|Rikenellaceae 976|Bacteroidetes T Tetratricopeptide repeat batE - - - - - - - - - - - SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2 CMS2_k127_6886956_29 1121121.KB894328_gene2260 2.047e-26 118.0 COG1266@1|root,COG1266@2|Bacteria,1VKKZ@1239|Firmicutes 1239|Firmicutes S CAAX protease self-immunity - - - - - - - - - - - - Abi CMS2_k127_6886956_6 1121377.KB906425_gene280 8.12e-157 505.0 COG2355@1|root,COG2355@2|Bacteria 2|Bacteria E Zn-dependent dipeptidase, microsomal dipeptidase - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 CMS2_k127_6886956_11 756883.Halar_1131 2.999e-119 400.0 COG0591@1|root,arCOG01316@2157|Archaea 2157|Archaea E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS2_k127_6886956_18 1101192.KB910516_gene1217 3.25e-107 362.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,1JRBF@119045|Methylobacteriaceae 28211|Alphaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC CMS2_k127_6886956_2 1047013.AQSP01000139_gene2323 2.529e-229 730.0 COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 CMS2_k127_6886956_3 452637.Oter_2107 1.974e-221 695.0 COG0034@1|root,COG0034@2|Bacteria,46SSU@74201|Verrucomicrobia 74201|Verrucomicrobia F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7 CMS2_k127_6886956_32 323848.Nmul_A0637 2.702e-13 80.0 COG3103@1|root,COG3103@2|Bacteria,1NQ5X@1224|Proteobacteria,2WA5G@28216|Betaproteobacteria,372RR@32003|Nitrosomonadales 28216|Betaproteobacteria T PFAM SH3, type 3 - - - - - - - - - - - - SH3_3 CMS2_k127_6917191_3 192952.MM_2290 3.046e-12 79.0 COG0860@1|root,arCOG08705@1|root,arCOG08705@2157|Archaea,arCOG09691@2157|Archaea,2Y4YX@28890|Euryarchaeota 28890|Euryarchaeota M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 CMS2_k127_6917191_1 314230.DSM3645_25739 1.044e-69 248.0 COG0628@1|root,COG0628@2|Bacteria,2J103@203682|Planctomycetes 203682|Planctomycetes S membrane protein-putative a permease - - - - - - - - - - - - AI-2E_transport CMS2_k127_6917191_0 518766.Rmar_1973 2.157e-91 308.0 COG1878@1|root,COG1878@2|Bacteria,4PIWM@976|Bacteroidetes,1FJPB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Putative cyclase - GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 ko:K07130 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Cyclase CMS2_k127_6917191_2 861299.J421_0238 5.496e-41 159.0 2F3IF@1|root,33WC0@2|Bacteria,1ZTPE@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_6922411_7 439497.RR11_2058 3.161e-28 119.0 COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,2TUF8@28211|Alphaproteobacteria,4NCXS@97050|Ruegeria 28211|Alphaproteobacteria I Fatty acid desaturase des - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase CMS2_k127_6922411_16 1267534.KB906760_gene1581 6.789e-05 49.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - TPR_16,TPR_8 CMS2_k127_6922411_12 1121904.ARBP01000003_gene6312 6.143e-07 52.0 COG0457@1|root,COG2207@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2207@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - HTH_18,TPR_8 CMS2_k127_6922411_3 477974.Daud_1722 8.169e-103 346.0 COG1180@1|root,COG1180@2|Bacteria,1V170@1239|Firmicutes,24E3W@186801|Clostridia 186801|Clostridia C Radical SAM superfamily - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM CMS2_k127_6922411_2 237368.SCABRO_02637 1.073e-107 359.0 COG1180@1|root,COG1180@2|Bacteria,2IYWA@203682|Planctomycetes 203682|Planctomycetes C Radical SAM superfamily - - - - - - - - - - - - Fer4_12,Radical_SAM CMS2_k127_6922411_4 179408.Osc7112_3796 2.559e-98 338.0 COG2234@1|root,COG2234@2|Bacteria,1G1QW@1117|Cyanobacteria,1H7N7@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 CMS2_k127_6922411_14 309803.CTN_0287 9.668e-06 57.0 COG1597@1|root,COG1597@2|Bacteria,2GCWI@200918|Thermotogae 200918|Thermotogae I diacylglycerol kinase, catalytic - - - - - - - - - - - - DAGK_cat CMS2_k127_6922411_6 1122132.AQYH01000006_gene3377 8.244e-30 134.0 COG0204@1|root,COG0204@2|Bacteria,1RA8V@1224|Proteobacteria,2U5DY@28211|Alphaproteobacteria,4B8QS@82115|Rhizobiaceae 28211|Alphaproteobacteria I Phosphate acyltransferases plsC - - - - - - - - - - - Acyltransferase CMS2_k127_6922411_8 523791.Kkor_1962 4.234e-27 121.0 COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,1RRAG@1236|Gammaproteobacteria,1XNNH@135619|Oceanospirillales 135619|Oceanospirillales S Cytidylyltransferase family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 CMS2_k127_6922411_9 163908.KB235896_gene699 2.25e-26 116.0 COG2445@1|root,COG2445@2|Bacteria,1G8TD@1117|Cyanobacteria 1117|Cyanobacteria S Protein of unknown function DUF86 - - - - - - - - - - - - DUF86 CMS2_k127_6922411_13 1094508.Tsac_0020 5.504e-06 54.0 COG1669@1|root,COG1669@2|Bacteria,1W5EB@1239|Firmicutes,255RV@186801|Clostridia 186801|Clostridia S nucleotidyltransferase activity - - - - - - - - - - - - NTP_transf_2 CMS2_k127_6922411_1 1499967.BAYZ01000022_gene223 6.673e-128 423.0 COG0006@1|root,COG0006@2|Bacteria,2NR73@2323|unclassified Bacteria 2|Bacteria E Metallopeptidase family M24 - - - - - - - - - - - - Peptidase_M24 CMS2_k127_6922411_10 1379270.AUXF01000001_gene2088 1.066e-07 62.0 2DDI2@1|root,2ZI6I@2|Bacteria,1ZVAF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_6922411_5 861299.J421_1682 1.467e-36 162.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 2|Bacteria T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C CMS2_k127_6922411_0 1379270.AUXF01000002_gene1364 1.17e-152 529.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1364|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_6922411_15 1121468.AUBR01000007_gene272 1.308e-05 52.0 2AHG6@1|root,317TF@2|Bacteria,1W4C8@1239|Firmicutes,255NM@186801|Clostridia,42IXG@68295|Thermoanaerobacterales 186801|Clostridia - - - - - - - - - - - - - - - CMS2_k127_6922411_11 1379270.AUXF01000003_gene3710 2.753e-07 52.0 COG2859@1|root,COG2859@2|Bacteria,1ZUNC@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL CMS2_k127_6947989_4 861299.J421_3181 6.296e-84 286.0 28Q1P@1|root,2ZB8E@2|Bacteria,1ZSPA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Zinc dependent phospholipase C - - - - - - - - - - - - Zn_dep_PLPC CMS2_k127_6947989_1 1379270.AUXF01000005_gene811 6.241e-220 704.0 COG0210@1|root,COG0210@2|Bacteria,1ZTD5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C CMS2_k127_6947989_6 861299.J421_3176 1.315e-76 273.0 COG5000@1|root,COG5000@2|Bacteria,1ZSKZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c CMS2_k127_6947989_2 861299.J421_3175 1.202e-139 456.0 COG0172@1|root,COG0172@2|Bacteria,1ZT0V@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b CMS2_k127_6947989_13 861299.J421_3174 2.615e-08 63.0 2FES0@1|root,346R1@2|Bacteria,1ZU3X@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_6947989_11 379066.GAU_1541 1.343e-25 110.0 COG2018@1|root,COG2018@2|Bacteria,1ZU1J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Roadblock/LC7 domain - - - ko:K07131 - - - - ko00000 - - - Robl_LC7 CMS2_k127_6947989_3 861299.J421_3171 2.524e-101 340.0 COG0836@1|root,COG0836@2|Bacteria,1ZT5Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Nucleotidyl transferase - - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase CMS2_k127_6947989_8 861299.J421_3170 3.703e-65 238.0 COG1208@1|root,COG1208@2|Bacteria,1ZSVN@142182|Gemmatimonadetes 142182|Gemmatimonadetes JM Sugar nucleotidyl transferase - - - - - - - - - - - - NTP_transf_4 CMS2_k127_6947989_9 379066.GAU_1537 1.048e-48 188.0 COG1235@1|root,COG1235@2|Bacteria,1ZTN8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 CMS2_k127_6947989_7 1379270.AUXF01000001_gene2066 1.733e-75 267.0 COG2206@1|root,COG2206@2|Bacteria 2|Bacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD CMS2_k127_6947989_12 439235.Dalk_1582 5.533e-15 89.0 COG1413@1|root,COG1413@2|Bacteria,1N5TU@1224|Proteobacteria,42UDF@68525|delta/epsilon subdivisions,2WQ3K@28221|Deltaproteobacteria,2MP61@213118|Desulfobacterales 28221|Deltaproteobacteria C lyase activity - - - - - - - - - - - - HEAT_2 CMS2_k127_6947989_0 379066.GAU_1536 3.974e-280 870.0 COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS2_k127_6947989_10 861299.J421_3163 1.182e-38 146.0 COG0234@1|root,COG0234@2|Bacteria,1ZTZB@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 CMS2_k127_6947989_5 1379270.AUXF01000004_gene2872 1.241e-78 278.0 COG0515@1|root,COG5184@1|root,COG0515@2|Bacteria,COG5184@2|Bacteria,1ZUHN@142182|Gemmatimonadetes 142182|Gemmatimonadetes DKLTZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - Pkinase,RCC1 CMS2_k127_6947989_14 1254432.SCE1572_16860 0.0005267 51.0 COG0515@1|root,COG0515@2|Bacteria 1254432.SCE1572_16860|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_700570_1 84531.JMTZ01000070_gene1816 1.756e-92 312.0 COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,1S0IS@1236|Gammaproteobacteria,1X4IQ@135614|Xanthomonadales 135614|Xanthomonadales I Fatty acid desaturase - - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase CMS2_k127_700570_0 331678.Cphamn1_1310 1.039e-101 341.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - 3.5.5.1 ko:K01501 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase CMS2_k127_700570_5 309801.trd_1978 6.068e-34 134.0 COG2250@1|root,COG2250@2|Bacteria,2G98F@200795|Chloroflexi 200795|Chloroflexi S HEPN domain - - - - - - - - - - - - HEPN CMS2_k127_700570_8 926550.CLDAP_40220 1.554e-12 75.0 COG1708@1|root,COG1708@2|Bacteria,2G9EI@200795|Chloroflexi 200795|Chloroflexi S Nucleotidyltransferase domain - - - - - - - - - - - - NTP_transf_2 CMS2_k127_700570_3 1379270.AUXF01000002_gene1589 1.975e-65 227.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1589|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_700570_7 1123325.JHUV01000008_gene920 3.562e-17 92.0 2E7Q4@1|root,3325M@2|Bacteria,2G503@200783|Aquificae 200783|Aquificae - - - - - - - - - - - - - - Cytochrom_C_2,Cytochrome_C554 CMS2_k127_700570_9 1205910.B005_4518 7.445e-07 57.0 COG1595@1|root,COG1595@2|Bacteria,2IHWH@201174|Actinobacteria,4EJNC@85012|Streptosporangiales 201174|Actinobacteria K Sigma-70, region 4 sigC GO:0001101,GO:0001666,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0036293,GO:0042221,GO:0044419,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051704,GO:0060255,GO:0065007,GO:0070482,GO:0080090,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_700570_10 1245469.S58_49830 2.563e-06 57.0 COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,3JRXS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Putative zinc-finger - - - - - - - - - - - - zf-HC2 CMS2_k127_700570_2 1237149.C900_01592 5.437e-84 293.0 295M7@1|root,2ZSYM@2|Bacteria,4NNH9@976|Bacteroidetes,47UGS@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_700570_6 570967.JMLV01000001_gene2678 9.906e-20 97.0 COG5455@1|root,COG5455@2|Bacteria,1N3PU@1224|Proteobacteria,2UGK9@28211|Alphaproteobacteria,2JUR7@204441|Rhodospirillales 204441|Rhodospirillales S response to cobalt ion - - - - - - - - - - - - - CMS2_k127_700570_4 1005048.CFU_2480 2.838e-48 175.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,472DU@75682|Oxalobacteraceae 28216|Betaproteobacteria P Phosphate transporter family pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 CMS2_k127_7022853_2 391625.PPSIR1_30651 4.588e-07 55.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis txlA - - - - - - - - - - - AhpC-TSA,Cu2_monoox_C,He_PIG,Pro_isomerase,Pyr_redox_2,Redoxin,Thioredoxin,Thioredoxin_3,Thioredoxin_8 CMS2_k127_7022853_0 1047013.AQSP01000125_gene2637 3.952e-75 277.0 COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria 2|Bacteria M serine-type peptidase activity tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N CMS2_k127_7022853_1 234267.Acid_1944 3.216e-70 256.0 COG2801@1|root,COG2801@2|Bacteria,3Y50C@57723|Acidobacteria 57723|Acidobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_23,HTH_32,rve CMS2_k127_7026771_5 1005048.CFU_3170 1.13e-137 451.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2VPBK@28216|Betaproteobacteria,476GH@75682|Oxalobacteraceae 28216|Betaproteobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N CMS2_k127_7026771_14 234267.Acid_2305 2.701e-27 114.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZC@57723|Acidobacteria 57723|Acidobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR CMS2_k127_7026771_17 1117319.PSPO_20206 8.183e-07 57.0 2ED1M@1|root,336YJ@2|Bacteria,1NF01@1224|Proteobacteria,1SFPN@1236|Gammaproteobacteria,2Q3C0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_7026771_9 1297742.A176_06444 3.021e-109 387.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_7026771_15 485913.Krac_5098 8.614e-22 99.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR CMS2_k127_7026771_12 362418.IW19_18080 8.199e-40 162.0 COG1266@1|root,COG1266@2|Bacteria,4NHRW@976|Bacteroidetes,1I1CE@117743|Flavobacteriia,2NVEX@237|Flavobacterium 976|Bacteroidetes S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS2_k127_7026771_11 1382306.JNIM01000001_gene2809 2.815e-108 359.0 COG3959@1|root,COG3959@2|Bacteria,2GA6J@200795|Chloroflexi 200795|Chloroflexi G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N CMS2_k127_7026771_6 1382306.JNIM01000001_gene2808 1.807e-129 423.0 COG3958@1|root,COG3958@2|Bacteria,2G8E1@200795|Chloroflexi 200795|Chloroflexi G Transketolase, pyrimidine binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C CMS2_k127_7026771_2 1382306.JNIM01000001_gene2807 9.157e-173 570.0 COG0554@1|root,COG0554@2|Bacteria,2G5TV@200795|Chloroflexi 2|Bacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK3 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N CMS2_k127_7026771_10 1382306.JNIM01000001_gene2806 1.026e-108 367.0 COG2390@1|root,COG2390@2|Bacteria,2G8CS@200795|Chloroflexi 200795|Chloroflexi K Putative sugar-binding domain - - - - - - - - - - - - Sigma70_r4,Sugar-bind CMS2_k127_7026771_16 349163.Acry_1065 2.985e-19 97.0 COG5618@1|root,COG5618@2|Bacteria,1MYCN@1224|Proteobacteria,2UAEG@28211|Alphaproteobacteria,2JY7S@204441|Rhodospirillales 204441|Rhodospirillales S Predicted periplasmic lipoprotein (DUF2291) - - - - - - - - - - - - DUF2291 CMS2_k127_7026771_4 1121127.JAFA01000014_gene6596 7.36e-141 473.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2VHRA@28216|Betaproteobacteria,1K5N9@119060|Burkholderiaceae 28216|Betaproteobacteria G ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran CMS2_k127_7026771_7 1382306.JNIM01000001_gene2803 1.522e-127 417.0 COG1172@1|root,COG1172@2|Bacteria,2G6A4@200795|Chloroflexi 200795|Chloroflexi G Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 CMS2_k127_7026771_8 1382306.JNIM01000001_gene2802 2.833e-125 408.0 COG1879@1|root,COG1879@2|Bacteria,2G6R2@200795|Chloroflexi 200795|Chloroflexi G Periplasmic binding proteins and sugar binding domain of LacI family - - - ko:K10439,ko:K17213 ko02010,ko02030,map02010,map02030 M00212,M00593 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 CMS2_k127_7026771_0 700598.Niako_0063 3.44e-240 749.0 COG2407@1|root,COG2407@2|Bacteria,4NFGS@976|Bacteroidetes,1IQRA@117747|Sphingobacteriia 976|Bacteroidetes G PFAM L-fucose isomerase, C-terminal domain - - - - - - - - - - - - Fucose_iso_C CMS2_k127_7026771_3 1123277.KB893239_gene1265 5.719e-154 495.0 COG2382@1|root,COG2382@2|Bacteria,4NFVV@976|Bacteroidetes,47PFY@768503|Cytophagia 976|Bacteroidetes P Belongs to the glycosyl hydrolase 13 family - - - ko:K07214 - - - - ko00000 - - - AMPK1_CBM,CBM_48,Esterase CMS2_k127_7026771_1 1280950.HJO_12581 5.334e-190 609.0 COG5297@1|root,COG5297@2|Bacteria,1NNDR@1224|Proteobacteria,2U2XN@28211|Alphaproteobacteria,43Z1I@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Protein of unknown function (DUF1593) - - - - - - - - - - - - DUF1593 CMS2_k127_7026771_13 1123008.KB905706_gene856 7.977e-28 115.0 COG3537@1|root,COG3537@2|Bacteria,4NI5B@976|Bacteroidetes,2FMQ3@200643|Bacteroidia,22X79@171551|Porphyromonadaceae 976|Bacteroidetes G Glycosyl hydrolase family 92 - - - - - - - - - - - - Glyco_hydro_92 CMS2_k127_7062166_81 1499968.TCA2_5335 1.704e-06 52.0 2EG8N@1|root,33A0G@2|Bacteria,1VMHK@1239|Firmicutes,4HRQH@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - CMS2_k127_7062166_54 1047013.AQSP01000122_gene2227 4.272e-27 115.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - ko:K02282,ko:K07705 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - GerE,Response_reg,TauD CMS2_k127_7062166_40 861299.J421_0908 1.526e-60 216.0 COG0494@1|root,COG0494@2|Bacteria,1ZTQ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX CMS2_k127_7062166_30 861299.J421_0907 2.102e-91 304.0 COG1595@1|root,COG1595@2|Bacteria,1ZT2V@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 CMS2_k127_7062166_45 1379270.AUXF01000002_gene1166 5.748e-51 194.0 COG1466@1|root,COG1466@2|Bacteria,1ZSSZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta CMS2_k127_7062166_73 861299.J421_0904 4.878e-11 73.0 COG1729@1|root,COG3087@1|root,COG1729@2|Bacteria,COG3087@2|Bacteria,1ZTSZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Sporulation related domain - - - - - - - - - - - - SPOR,TPR_6 CMS2_k127_7062166_5 1125863.JAFN01000001_gene2068 9.734e-230 744.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria 28221|Deltaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V CMS2_k127_7062166_79 84531.JMTZ01000022_gene4191 2.308e-07 58.0 COG0810@1|root,COG0810@2|Bacteria,1PDQZ@1224|Proteobacteria,1SWIV@1236|Gammaproteobacteria,1X88P@135614|Xanthomonadales 135614|Xanthomonadales M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C CMS2_k127_7062166_8 1379270.AUXF01000002_gene1158 2.151e-181 580.0 COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1ZTA6@142182|Gemmatimonadetes 142182|Gemmatimonadetes EK Domain in cystathionine beta-synthase and other proteins. - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP CMS2_k127_7062166_62 519989.ECTPHS_00125 7.69e-22 100.0 COG0720@1|root,COG0720@2|Bacteria,1PNDM@1224|Proteobacteria,1S7ZW@1236|Gammaproteobacteria,1WZ30@135613|Chromatiales 135613|Chromatiales H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS CMS2_k127_7062166_26 1133849.O3I_031645 2.133e-100 338.0 COG1181@1|root,COG1181@2|Bacteria,2I8SB@201174|Actinobacteria,4G09W@85025|Nocardiaceae 201174|Actinobacteria M D-ala D-ala ligase C-terminus - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C CMS2_k127_7062166_49 861299.J421_0895 3.169e-42 166.0 COG0705@1|root,COG0705@2|Bacteria,1ZSWV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Rhomboid family - - - - - - - - - - - - Rhomboid CMS2_k127_7062166_25 1379270.AUXF01000002_gene1184 1.017e-100 340.0 COG5504@1|root,COG5504@2|Bacteria,1ZTCN@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Zn-dependent protease - - - - - - - - - - - - - CMS2_k127_7062166_18 1379270.AUXF01000002_gene1185 2.933e-110 371.0 COG0486@1|root,COG0486@2|Bacteria,1ZSRA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N CMS2_k127_7062166_14 861299.J421_1067 2.538e-121 409.0 COG0706@1|root,COG0706@2|Bacteria,1ZSKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas CMS2_k127_7062166_61 479436.Vpar_1857 1.899e-22 104.0 COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,4H5K3@909932|Negativicutes 909932|Negativicutes S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic CMS2_k127_7062166_71 861299.J421_1069 5.767e-12 72.0 COG0594@1|root,COG0594@2|Bacteria,1ZV89@142182|Gemmatimonadetes 142182|Gemmatimonadetes J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P CMS2_k127_7062166_68 379066.GAU_3935 5.421e-15 75.0 COG0230@1|root,COG0230@2|Bacteria,1ZU59@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L34 rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 CMS2_k127_7062166_15 867903.ThesuDRAFT_00468 1.606e-117 394.0 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,3WCSH@538999|Clostridiales incertae sedis 186801|Clostridia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N CMS2_k127_7062166_10 861299.J421_1072 1.756e-172 548.0 COG0592@1|root,COG0592@2|Bacteria,1ZT22@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_3 CMS2_k127_7062166_69 667121.ET1_24_00500 2.11e-14 77.0 2DMTH@1|root,32TKP@2|Bacteria,1N4TE@1224|Proteobacteria,1S9K6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_7062166_41 379066.GAU_0004 3.654e-55 204.0 COG2207@1|root,COG2207@2|Bacteria,1ZTPX@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 CMS2_k127_7062166_66 1457250.BBMO01000001_gene962 7.599e-17 94.0 COG0840@1|root,arCOG02320@2157|Archaea,2XUA9@28890|Euryarchaeota,23TAT@183963|Halobacteria 183963|Halobacteria N Methyl-accepting chemotaxis protein htr14 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal CMS2_k127_7062166_44 379066.GAU_0007 2.068e-51 188.0 COG0461@1|root,COG0461@2|Bacteria,1ZTMR@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran CMS2_k127_7062166_28 379066.GAU_0008 2.065e-95 321.0 COG0515@1|root,COG0515@2|Bacteria,1ZT9E@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_7062166_51 861299.J421_1054 7.421e-33 147.0 COG0741@1|root,COG0741@2|Bacteria 2|Bacteria M lytic transglycosylase activity slt GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 iETEC_1333.ETEC_4747,iPC815.YPO0452 SLT,SLT_L CMS2_k127_7062166_82 290512.Paes_0453 3.02e-05 55.0 COG0170@1|root,COG0170@2|Bacteria,1FDXW@1090|Chlorobi 1090|Chlorobi I PFAM phosphatidate cytidylyltransferase - - - - - - - - - - - - - CMS2_k127_7062166_60 395495.Lcho_1662 1.108e-24 104.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,1KMN9@119065|unclassified Burkholderiales 28216|Betaproteobacteria K 'Cold-shock' DNA-binding domain cspD - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS2_k127_7062166_1 861299.J421_1151 9.55e-311 977.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1ZTCF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 CMS2_k127_7062166_78 1232437.KL662002_gene4692 2.65e-08 61.0 COG4969@1|root,COG4969@2|Bacteria,1QV9X@1224|Proteobacteria,42W4E@68525|delta/epsilon subdivisions,2X70G@28221|Deltaproteobacteria,2MM3H@213118|Desulfobacterales 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl CMS2_k127_7062166_55 861299.J421_1153 5.719e-27 114.0 2CIIM@1|root,348GD@2|Bacteria,1ZU31@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_7062166_20 1267534.KB906759_gene1822 6.462e-108 377.0 COG2409@1|root,COG2409@2|Bacteria 2|Bacteria D Drug exporters of the RND superfamily mmpL3 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - ko:K06994,ko:K07003,ko:K20466,ko:K20470 - - - - ko00000,ko02000 2.A.6.5.5,2.A.6.5.6 - - MMPL CMS2_k127_7062166_52 861299.J421_2118 4.204e-32 134.0 COG5549@1|root,COG5549@2|Bacteria,1ZTQC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Matrixin - - - - - - - - - - - - Peptidase_M10 CMS2_k127_7062166_48 506534.Rhein_1214 4.604e-45 182.0 COG2234@1|root,COG2234@2|Bacteria,1MUZ7@1224|Proteobacteria,1RS0Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 CMS2_k127_7062166_32 379066.GAU_3015 4.608e-85 295.0 COG1680@1|root,COG1680@2|Bacteria,1ZTCC@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase CMS2_k127_7062166_75 525367.HMPREF0556_12525 1.377e-09 66.0 COG3011@1|root,COG3011@2|Bacteria,1U9QN@1239|Firmicutes,4IJWV@91061|Bacilli,26M1T@186820|Listeriaceae 91061|Bacilli S Protein of unknown function, DUF393 - - - - - - - - - - - - DUF393 CMS2_k127_7062166_53 1379270.AUXF01000001_gene2407 3.075e-31 131.0 COG2151@1|root,COG2151@2|Bacteria,1ZTUD@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulfur cluster assembly protein - - - - - - - - - - - - FeS_assembly_P CMS2_k127_7062166_23 861299.J421_2109 7.327e-104 351.0 COG0349@1|root,COG0349@2|Bacteria,1ZSPS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J 3'-5' exonuclease - - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC CMS2_k127_7062166_50 1499967.BAYZ01000033_gene1075 1.52e-35 145.0 COG0242@1|root,COG0242@2|Bacteria 2|Bacteria J peptide deformylase activity - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - HTH_31,Pep_deformylase CMS2_k127_7062166_57 1232437.KL661971_gene4824 1.89e-26 116.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,42SCH@68525|delta/epsilon subdivisions,2WPMA@28221|Deltaproteobacteria,2MKPV@213118|Desulfobacterales 28221|Deltaproteobacteria S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 CMS2_k127_7062166_65 1047013.AQSP01000058_gene2028 6.329e-18 96.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,TolB_like CMS2_k127_7062166_58 326427.Cagg_1682 4.584e-26 111.0 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity MA20_23570 - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_34 CMS2_k127_7062166_47 861299.J421_2091 4.294e-45 172.0 COG2345@1|root,COG2345@2|Bacteria,1ZTKU@142182|Gemmatimonadetes 142182|Gemmatimonadetes K HTH domain - - - - - - - - - - - - HTH_20 CMS2_k127_7062166_3 1191523.MROS_0344 8.886e-250 777.0 COG0719@1|root,COG0719@2|Bacteria 2|Bacteria O iron-sulfur cluster assembly sufB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - ko:K07033,ko:K09014 - - - - ko00000 - - iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078 UPF0051 CMS2_k127_7062166_16 379066.GAU_3028 1.886e-114 374.0 COG0396@1|root,COG0396@2|Bacteria,1ZSRX@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ABC transporter sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran CMS2_k127_7062166_24 323261.Noc_2488 1.859e-101 346.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1WWK5@135613|Chromatiales 135613|Chromatiales O FeS assembly protein SufD - - - ko:K09015 - - - - ko00000 - - - UPF0051 CMS2_k127_7062166_9 105559.Nwat_0647 1.629e-172 550.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales 135613|Chromatiales E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5,SufE CMS2_k127_7062166_42 1183438.GKIL_1934 1.557e-51 186.0 COG0822@1|root,COG0822@2|Bacteria,1G590@1117|Cyanobacteria 1117|Cyanobacteria C SUF system FeS assembly protein, NifU family - - - ko:K04488 - - - - ko00000 - - - NifU_N CMS2_k127_7062166_64 656024.FsymDg_1716 5.158e-18 88.0 COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4ETAR@85013|Frankiales 201174|Actinobacteria P PFAM Rieske 2Fe-2S hcaC - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske CMS2_k127_7062166_84 246197.MXAN_4315 6.901e-05 54.0 COG5662@1|root,COG5662@2|Bacteria,1R8JM@1224|Proteobacteria,434SA@68525|delta/epsilon subdivisions,2WZ3C@28221|Deltaproteobacteria,2Z18J@29|Myxococcales 28221|Deltaproteobacteria K Putative zinc-finger - - - - - - - - - - - - zf-HC2 CMS2_k127_7062166_19 1234364.AMSF01000024_gene3768 1.031e-109 364.0 COG4152@1|root,COG4152@2|Bacteria,1QUPV@1224|Proteobacteria,1T47Q@1236|Gammaproteobacteria,1XD8K@135614|Xanthomonadales 135614|Xanthomonadales S ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_7062166_34 1234364.AMSF01000024_gene3767 1.742e-78 280.0 COG1668@1|root,COG1668@2|Bacteria,1R62N@1224|Proteobacteria 1224|Proteobacteria CP COG1668 ABC-type Na efflux pump, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS2_k127_7062166_7 391598.FBBAL38_05170 6.307e-188 606.0 COG0445@1|root,COG0445@2|Bacteria,4NFNH@976|Bacteroidetes,1HWN4@117743|Flavobacteriia 976|Bacteroidetes D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc CMS2_k127_7062166_27 861299.J421_1165 1.182e-97 325.0 COG1192@1|root,COG1192@2|Bacteria,1ZTH2@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 CMS2_k127_7062166_35 861299.J421_1167 1.497e-77 269.0 COG1475@1|root,COG1475@2|Bacteria,1ZSKT@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc CMS2_k127_7062166_59 340099.Teth39_0101 1.298e-25 117.0 COG0739@1|root,COG3583@1|root,COG0739@2|Bacteria,COG3583@2|Bacteria,1TRWJ@1239|Firmicutes,24A2J@186801|Clostridia,42FT7@68295|Thermoanaerobacterales 186801|Clostridia M G5 domain protein - - - - - - - - - - - - G5,LysM,Peptidase_M23 CMS2_k127_7062166_67 1235797.C816_04088 3.199e-15 82.0 COG1664@1|root,COG1664@2|Bacteria 2|Bacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin CMS2_k127_7062166_38 497964.CfE428DRAFT_0749 4.601e-70 247.0 COG0327@1|root,COG0327@2|Bacteria 2|Bacteria L Belongs to the GTP cyclohydrolase I type 2 NIF3 family ybgI GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - NIF3 CMS2_k127_7062166_37 1303518.CCALI_00872 4.242e-70 249.0 COG1600@1|root,COG1600@2|Bacteria 2|Bacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 CMS2_k127_7062166_56 1379270.AUXF01000001_gene2453 1.879e-26 112.0 2FKCY@1|root,34C0C@2|Bacteria,1ZU3I@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_7062166_21 316274.Haur_3782 2.675e-107 360.0 COG0520@1|root,COG0520@2|Bacteria,2G7N0@200795|Chloroflexi,377HP@32061|Chloroflexia 32061|Chloroflexia H PFAM aminotransferase class V - - - - - - - - - - - - Aminotran_5 CMS2_k127_7062166_33 266117.Rxyl_2215 9.016e-79 272.0 COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4CQ3Q@84995|Rubrobacteria 84995|Rubrobacteria S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox CMS2_k127_7062166_11 251221.35211608 2.829e-154 496.0 COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria 1117|Cyanobacteria O Belongs to the deoxyhypusine synthase family - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS CMS2_k127_7062166_13 740709.A10D4_06641 3.421e-122 405.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,2QF34@267893|Idiomarinaceae 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadI GO:0003674,GO:0003824,GO:0003857,GO:0003988,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033542,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_2806,iEcHS_1320.EcHS_A2493 Thiolase_C,Thiolase_N CMS2_k127_7062166_6 1379270.AUXF01000001_gene2467 5.539e-219 700.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1ZT1A@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Enoyl-CoA hydratase/isomerase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 CMS2_k127_7062166_31 479434.Sthe_2631 2.123e-90 306.0 COG0506@1|root,COG0506@2|Bacteria,2G6B6@200795|Chloroflexi,27XF7@189775|Thermomicrobia 189775|Thermomicrobia C Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh CMS2_k127_7062166_74 861299.J421_4532 5.747e-10 64.0 2FDUV@1|root,345VG@2|Bacteria,1ZTXA@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_7062166_39 1379270.AUXF01000001_gene2472 1.288e-67 242.0 COG1162@1|root,COG1162@2|Bacteria,1ZSSQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase CMS2_k127_7062166_43 290397.Adeh_2453 1.671e-51 198.0 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2Z31V@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 CMS2_k127_7062166_72 379066.GAU_2808 3.235e-11 68.0 2FCBU@1|root,344FF@2|Bacteria,1ZU39@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_7062166_0 379066.GAU_2797 5.551e-315 979.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C CMS2_k127_7062166_17 861299.J421_4449 1.654e-113 389.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_7062166_4 693977.Deipr_0266 1.789e-241 769.0 COG0466@1|root,COG0466@2|Bacteria,1WISX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C CMS2_k127_7062166_70 1206720.BAFQ01000291_gene6225 4.723e-12 74.0 COG1309@1|root,COG1309@2|Bacteria,2IE9K@201174|Actinobacteria,4G0ZJ@85025|Nocardiaceae 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N CMS2_k127_7062166_77 588932.JHOF01000018_gene1037 2.049e-08 64.0 COG1378@1|root,COG1378@2|Bacteria,1N9ZU@1224|Proteobacteria,2U7Z9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Sugar-specific transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB CMS2_k127_7062166_46 379066.GAU_2771 2.153e-49 192.0 2EW3S@1|root,33PH0@2|Bacteria,1ZTQG@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_7062166_36 555088.DealDRAFT_2287 3.291e-72 259.0 COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,24ADG@186801|Clostridia 186801|Clostridia M Putative glycosyl hydrolase domain - - - - - - - - - - - - DUF4015 CMS2_k127_7062166_29 59374.Fisuc_1592 2.873e-93 326.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - - - - - - - - - - OmpA,TSP_3 CMS2_k127_7062166_63 401526.TcarDRAFT_0240 1.529e-19 104.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H2YC@909932|Negativicutes 909932|Negativicutes NT SMART chemotaxis sensory transducer, histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CHASE3,HAMP,MCPsignal CMS2_k127_7062166_76 997346.HMPREF9374_0031 1.52e-09 60.0 COG3526@1|root,COG3526@2|Bacteria,1VKFI@1239|Firmicutes,4HR9S@91061|Bacilli 91061|Bacilli O Rdx family - - - ko:K07401 - - - - ko00000 - - - Rdx CMS2_k127_7062166_12 357808.RoseRS_1829 2.928e-131 430.0 COG0205@1|root,COG0205@2|Bacteria,2G6CJ@200795|Chloroflexi,374WW@32061|Chloroflexia 32061|Chloroflexia F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK CMS2_k127_7062166_22 1499967.BAYZ01000172_gene5771 7.085e-105 355.0 COG1301@1|root,COG1301@2|Bacteria,2NP6X@2323|unclassified Bacteria 2|Bacteria U Sodium:dicarboxylate symporter family gltT - - - - - - - - - - - SDF CMS2_k127_7062166_2 861299.J421_4433 3.879e-285 906.0 COG1643@1|root,COG1643@2|Bacteria,1ZSN8@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Atp-dependent helicase - - - - - - - - - - - - - CMS2_k127_7062166_80 1123226.KB899306_gene2715 3.475e-07 60.0 COG1309@1|root,COG1309@2|Bacteria,1V5AJ@1239|Firmicutes,4HI7X@91061|Bacilli,26XGU@186822|Paenibacillaceae 91061|Bacilli K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_6,TetR_N CMS2_k127_7062166_83 395494.Galf_2286 5.458e-05 49.0 COG0784@1|root,COG2202@1|root,COG3437@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg CMS2_k127_7069108_3 1244869.H261_12764 1.042e-46 174.0 COG2905@1|root,COG2905@2|Bacteria,1R907@1224|Proteobacteria,2TUV2@28211|Alphaproteobacteria,2JTIB@204441|Rhodospirillales 204441|Rhodospirillales T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding CMS2_k127_7069108_2 760192.Halhy_0668 1.471e-84 295.0 COG0845@1|root,COG0845@2|Bacteria,4NKUY@976|Bacteroidetes 976|Bacteroidetes M Biotin-lipoyl like - - - ko:K02022 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 CMS2_k127_7069108_0 760192.Halhy_0667 5.039e-248 788.0 COG2274@1|root,COG2274@2|Bacteria,4NIGB@976|Bacteroidetes 976|Bacteroidetes V Papain-like cysteine protease AvrRpt2 - - - - - - - - - - - - ABC_membrane,ABC_tran,Peptidase_C39 CMS2_k127_7069108_1 760192.Halhy_0666 2.752e-207 678.0 COG2274@1|root,COG2274@2|Bacteria,4NH0Y@976|Bacteroidetes 976|Bacteroidetes V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran CMS2_k127_7069108_4 1123508.JH636442_gene4266 1.575e-16 83.0 COG2128@1|root,COG2128@2|Bacteria,2IZDY@203682|Planctomycetes 203682|Planctomycetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD CMS2_k127_7069108_5 1123508.JH636442_gene4266 8.409e-06 48.0 COG2128@1|root,COG2128@2|Bacteria,2IZDY@203682|Planctomycetes 203682|Planctomycetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD CMS2_k127_7069740_3 886293.Sinac_6279 5.702e-29 117.0 COG3682@1|root,COG3682@2|Bacteria,2J0QT@203682|Planctomycetes 203682|Planctomycetes K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R CMS2_k127_7069740_5 1250005.PHEL85_1518 0.0009869 44.0 COG0823@1|root,COG0823@2|Bacteria,4NJN5@976|Bacteroidetes,1I0Y8@117743|Flavobacteriia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 CMS2_k127_7069740_0 1183438.GKIL_4354 9.69e-179 591.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_7069740_4 234267.Acid_2305 2.263e-27 114.0 COG1695@1|root,COG1695@2|Bacteria,3Y5ZC@57723|Acidobacteria 57723|Acidobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR CMS2_k127_7069740_1 234267.Acid_4431 8.976e-91 325.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 CMS2_k127_7069740_2 1379270.AUXF01000007_gene994 4.439e-71 248.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene994|- KLT protein kinase activity - - - - - - - - - - - - - CMS2_k127_777011_6 1267535.KB906767_gene2494 3.115e-11 64.0 COG4455@1|root,COG4455@2|Bacteria,3Y73H@57723|Acidobacteria 57723|Acidobacteria S ImpE protein - - - ko:K11898 - - - - ko00000,ko02044 - - - ImpE CMS2_k127_777011_2 234267.Acid_0235 5.519e-145 484.0 COG3515@1|root,COG3515@2|Bacteria,3Y2NF@57723|Acidobacteria 57723|Acidobacteria S ImpA, N-terminal, type VI secretion system - - - ko:K11902 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 - - - ImpA_N,T6SS_VasJ CMS2_k127_777011_4 234267.Acid_0236 3.17e-42 160.0 COG3518@1|root,COG3518@2|Bacteria,3Y5IK@57723|Acidobacteria 57723|Acidobacteria S Gene 25-like lysozyme - - - ko:K11897 - M00334 - - ko00000,ko00002,ko02044 - - - GPW_gp25 CMS2_k127_777011_1 234267.Acid_0237 2.481e-227 720.0 COG3519@1|root,COG3519@2|Bacteria,3Y34T@57723|Acidobacteria 57723|Acidobacteria S Type VI secretion system, TssF - - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF CMS2_k127_777011_3 1267535.KB906767_gene2498 4.691e-109 364.0 COG3520@1|root,COG3520@2|Bacteria,3Y49W@57723|Acidobacteria,2JMM9@204432|Acidobacteriia 204432|Acidobacteriia S type VI secretion protein, VC_A0111 family - - - ko:K11895 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_TssG CMS2_k127_777011_0 682795.AciX8_2869 0.0 1144.0 COG0542@1|root,COG0542@2|Bacteria,3Y3ND@57723|Acidobacteria,2JM05@204432|Acidobacteriia 204432|Acidobacteriia O C-terminal, D2-small domain, of ClpB protein - - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N CMS2_k127_777011_5 330214.NIDE1987 9.863e-33 131.0 COG3501@1|root,COG4253@1|root,COG3501@2|Bacteria,COG4253@2|Bacteria,3J13S@40117|Nitrospirae 40117|Nitrospirae S Phage late control gene D protein (GPD) - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD CMS2_k127_897374_12 105422.BBPM01000078_gene66 2.081e-11 75.0 COG2730@1|root,COG3291@1|root,COG3420@1|root,COG2730@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,2I41P@201174|Actinobacteria,2NNHT@228398|Streptacidiphilus 201174|Actinobacteria G Carbohydrate binding domain - - - - - - - - - - - - Beta_helix,CBM_4_9 CMS2_k127_897374_4 1122179.KB890418_gene3761 3.658e-86 291.0 COG2010@1|root,COG2010@2|Bacteria,4PN3J@976|Bacteroidetes 976|Bacteroidetes C Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 CMS2_k127_897374_1 1123008.KB905696_gene2948 8.187e-258 812.0 COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,2FM1I@200643|Bacteroidia,22VXA@171551|Porphyromonadaceae 976|Bacteroidetes S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - F5_F8_type_C,Glyco_hydro_127 CMS2_k127_897374_11 290315.Clim_1090 4.038e-12 72.0 2EGCR@1|root,33A4I@2|Bacteria,1FF72@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - CMS2_k127_897374_6 935863.AWZR01000001_gene1762 1.092e-62 222.0 29M6H@1|root,3083Y@2|Bacteria,1RJTC@1224|Proteobacteria,1T7NK@1236|Gammaproteobacteria,1X9GZ@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - CMS2_k127_897374_9 1173021.ALWA01000010_gene1468 2.094e-36 146.0 COG1309@1|root,COG1309@2|Bacteria,1G61G@1117|Cyanobacteria 1117|Cyanobacteria K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N,WHG CMS2_k127_897374_2 861299.J421_2248 7.711e-233 737.0 COG0446@1|root,COG0446@2|Bacteria 2|Bacteria Q pyridine nucleotide-disulphide oxidoreductase - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB CMS2_k127_897374_0 861299.J421_2247 0.0 1137.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec CMS2_k127_897374_5 1185876.BN8_00796 4.053e-75 267.0 COG1680@1|root,COG1680@2|Bacteria,4NHA7@976|Bacteroidetes,47R7U@768503|Cytophagia 976|Bacteroidetes V Beta-lactamase - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase CMS2_k127_897374_10 1379270.AUXF01000001_gene2088 1.444e-14 79.0 2DDI2@1|root,2ZI6I@2|Bacteria,1ZVAF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_897374_7 1163745.HCD_06370 2.545e-55 205.0 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,42QE7@68525|delta/epsilon subdivisions,2YNGU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sel1 repeat protein - - - ko:K07126 - - - - ko00000 - - - Sel1 CMS2_k127_897374_3 525904.Tter_2344 6.768e-208 666.0 COG1472@1|root,COG1472@2|Bacteria,2NQT7@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolase family 3 C-terminal domain bgxA - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C CMS2_k127_897374_8 118161.KB235922_gene1700 1.257e-36 141.0 COG3631@1|root,COG3631@2|Bacteria,1GF80@1117|Cyanobacteria 1117|Cyanobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 CMS2_k127_941703_33 525904.Tter_1549 4.698e-43 168.0 COG0157@1|root,COG0157@2|Bacteria,2NP3F@2323|unclassified Bacteria 2|Bacteria H Belongs to the NadC ModD family nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0030312,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 1.4.3.16,2.4.2.19 ko:K00278,ko:K00767 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481,R03348 RC00006,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N CMS2_k127_941703_36 1379270.AUXF01000001_gene2593 2.217e-10 64.0 2CA9X@1|root,2ZJY8@2|Bacteria,1ZU1S@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_941703_20 867903.ThesuDRAFT_01424 1.578e-70 250.0 COG1090@1|root,COG1090@2|Bacteria,1TRCE@1239|Firmicutes,24GWH@186801|Clostridia 186801|Clostridia S PFAM NAD dependent epimerase dehydratase family - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase CMS2_k127_941703_5 867903.ThesuDRAFT_00352 5.147e-192 624.0 COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis 186801|Clostridia C TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig CMS2_k127_941703_35 1127673.GLIP_4180 6.107e-19 94.0 COG3216@1|root,COG3216@2|Bacteria,1N1Q6@1224|Proteobacteria,1S9HF@1236|Gammaproteobacteria,467XY@72275|Alteromonadaceae 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) - - - - - - - - - - - - DUF2062 CMS2_k127_941703_34 1123279.ATUS01000001_gene2533 3.374e-20 106.0 COG2982@1|root,COG2982@2|Bacteria,1P6EN@1224|Proteobacteria,1S1EC@1236|Gammaproteobacteria,1J9AE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Protein involved in outer membrane biogenesis - - - - - - - - - - - - DUF748 CMS2_k127_941703_40 861299.J421_0429 1.376e-07 61.0 294MB@1|root,2ZS0S@2|Bacteria,1ZU7M@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_941703_3 379066.GAU_3048 1.835e-226 730.0 COG2366@1|root,COG2366@2|Bacteria,1ZT5C@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase CMS2_k127_941703_38 234267.Acid_2432 1.529e-09 66.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB CMS2_k127_941703_0 880073.Calab_0527 0.0 1116.0 COG0454@1|root,COG1022@1|root,COG0456@2|Bacteria,COG1022@2|Bacteria 2|Bacteria I Amp-dependent synthetase and ligase fadD - 2.5.1.16,6.2.1.3 ko:K00797,ko:K01897 ko00061,ko00071,ko00270,ko00330,ko00410,ko00480,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00270,map00330,map00410,map00480,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00034,M00086,M00133 R01280,R01920,R02869,R08359 RC00004,RC00014,RC00021,RC00053 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding CMS2_k127_941703_4 1232410.KI421421_gene3560 5.43e-223 699.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,43SA1@69541|Desulfuromonadales 28221|Deltaproteobacteria C Citrate synthase, C-terminal domain gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt CMS2_k127_941703_14 861299.J421_2012 2.924e-92 313.0 COG0604@1|root,COG0604@2|Bacteria,1ZT6R@142182|Gemmatimonadetes 2|Bacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 CMS2_k127_941703_25 670487.Ocepr_0255 7.375e-60 220.0 COG1409@1|root,COG1409@2|Bacteria,1WINK@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos CMS2_k127_941703_19 861299.J421_0787 1.763e-72 255.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 CMS2_k127_941703_7 926560.KE387023_gene1710 2.108e-159 514.0 COG0205@1|root,COG0205@2|Bacteria 2|Bacteria G 6-phosphofructokinase activity pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK CMS2_k127_941703_2 1049564.TevJSym_aa02390 1.465e-226 709.0 COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,1RQ6N@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N CMS2_k127_941703_28 195250.CM001776_gene4026 1.013e-54 199.0 COG1394@1|root,COG1394@2|Bacteria,1G6D2@1117|Cyanobacteria,1H34F@1129|Synechococcus 1117|Cyanobacteria L ATP synthase subunit D - - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D CMS2_k127_941703_6 765911.Thivi_3988 4.243e-177 574.0 COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RY40@1236|Gammaproteobacteria,1WXJ9@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I CMS2_k127_941703_29 1122599.AUGR01000001_gene320 1.708e-50 188.0 COG0636@1|root,COG0636@2|Bacteria,1RB4B@1224|Proteobacteria,1S2I4@1236|Gammaproteobacteria,1XJFU@135619|Oceanospirillales 135619|Oceanospirillales C the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C CMS2_k127_941703_31 765913.ThidrDRAFT_3268 7.574e-49 184.0 COG1390@1|root,COG1390@2|Bacteria,1MYFC@1224|Proteobacteria,1S1YK@1236|Gammaproteobacteria,1WWH9@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane - - - ko:K02121 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - - CMS2_k127_941703_24 765911.Thivi_3985 1.811e-61 221.0 28P4X@1|root,2ZC02@2|Bacteria,1RB0B@1224|Proteobacteria,1S2S5@1236|Gammaproteobacteria,1WY6M@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - DUF2764 CMS2_k127_941703_1 195250.CM001776_gene4021 4.477e-288 894.0 COG1155@1|root,COG1155@2|Bacteria,1G3Z2@1117|Cyanobacteria,1H2F6@1129|Synechococcus 1117|Cyanobacteria C ATPsynthase alpha/beta subunit N-term extension - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn CMS2_k127_941703_9 671143.DAMO_0821 3.914e-148 477.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B CMS2_k127_941703_32 671143.DAMO_0820 2.875e-45 173.0 COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria 2|Bacteria C Rieske [2Fe-2S] domain petA - 1.10.2.2,1.10.9.1 ko:K00411,ko:K02636,ko:K03886 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - iAF987.Gmet_1922 CytB6-F_Fe-S,Rieske,UCR_Fe-S_N CMS2_k127_941703_12 671143.DAMO_0822 1.044e-108 366.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS2_k127_941703_8 1379698.RBG1_1C00001G0297 2.294e-156 502.0 COG4881@1|root,COG4881@2|Bacteria 2|Bacteria - - cbcU - - - - - - - - - - - NrfD CMS2_k127_941703_15 1379698.RBG1_1C00001G0296 3.899e-91 308.0 COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 CMS2_k127_941703_17 1379698.RBG1_1C00001G0295 4.619e-75 259.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - ko:K04013,ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_C552,Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1 CMS2_k127_941703_42 1174504.AJTN02000185_gene101 0.0003759 49.0 COG2146@1|root,COG2146@2|Bacteria,1V1PE@1239|Firmicutes,4HFSE@91061|Bacilli,1ZEA4@1386|Bacillus 91061|Bacilli P COG0723 Rieske Fe-S protein - - 1.20.2.1,1.20.9.1 ko:K08355 - - - - ko00000,ko01000,ko02000 5.A.3.6 - - Rieske CMS2_k127_941703_27 1379698.RBG1_1C00001G0780 5.714e-55 211.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B CMS2_k127_941703_26 671143.DAMO_0822 3.018e-56 213.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB CMS2_k127_941703_11 671143.DAMO_0826 5.837e-118 406.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - ko:K02569,ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT,Cytochrome_C7 CMS2_k127_941703_16 290398.Csal_1575 4.051e-75 267.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1XHN2@135619|Oceanospirillales 135619|Oceanospirillales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE CMS2_k127_941703_23 1207063.P24_03376 2.443e-64 231.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2U8WM@28211|Alphaproteobacteria,2JZFM@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA CMS2_k127_941703_13 1047013.AQSP01000102_gene980 1.067e-92 318.0 COG2515@1|root,COG2515@2|Bacteria,2NP9B@2323|unclassified Bacteria 2|Bacteria E Pyridoxal-phosphate dependent enzyme - - 4.4.1.15,4.4.1.25 ko:K05396,ko:K17950 ko00270,map00270 - R01874,R07634 RC00382,RC01784 ko00000,ko00001,ko01000 - - - PALP CMS2_k127_941703_18 761193.Runsl_4309 7.843e-74 264.0 COG0520@1|root,COG0520@2|Bacteria,4NF4G@976|Bacteroidetes,47KCX@768503|Cytophagia 976|Bacteroidetes E PFAM aminotransferase class V - - - - - - - - - - - - Aminotran_5 CMS2_k127_941703_37 861299.J421_2595 3.866e-10 68.0 2F73W@1|root,33ZJG@2|Bacteria,1ZTT7@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_941703_22 861299.J421_2596 4.275e-65 247.0 2EW4E@1|root,33PHK@2|Bacteria,1ZT53@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - CMS2_k127_941703_10 1379270.AUXF01000004_gene3232 6.608e-140 459.0 COG2204@1|root,COG2204@2|Bacteria,1ZSW0@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_941703_21 379066.GAU_0652 1.69e-66 241.0 COG5000@1|root,COG5000@2|Bacteria,1ZTBX@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA CMS2_k127_941703_30 861299.J421_0340 2.106e-50 190.0 COG3595@1|root,COG3595@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4097,PA14 CMS2_k127_941703_41 13684.SNOT_14026 0.0003116 44.0 2D3PD@1|root,2SS8U@2759|Eukaryota,3A58J@33154|Opisthokonta,3P433@4751|Fungi,3QW8J@4890|Ascomycota,205CQ@147541|Dothideomycetes,4KHYM@92860|Pleosporales 4751|Fungi S Necrosis inducing protein (NPP1) - - - - - - - - - - - - NPP1 ## 4288 queries scanned ## Total time (seconds): 72.48003339767456 ## Rate: 59.16 q/s