## Fri Nov 8 13:47:55 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bins_4635/CMS2_bin.21.fa -m mmseqs --itype genome -o CMS2_bin.21 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/CMS2_bin.21 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs CMS2_k127_1013364_0 326298.Suden_0067 1.414e-80 271.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2YNX4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N CMS2_k127_1013364_1 563040.Saut_2015 5.4e-26 108.0 COG0291@1|root,COG0291@2|Bacteria,1QDQ4@1224|Proteobacteria,42VSG@68525|delta/epsilon subdivisions,2YQAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p CMS2_k127_1013364_2 326298.Suden_0207 7.643e-16 78.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,42REF@68525|delta/epsilon subdivisions,2YP4V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 CMS2_k127_1025566_4 1165841.SULAR_00990 3.379e-105 342.0 COG1013@1|root,COG1013@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor forB2 - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C CMS2_k127_1025566_3 1165841.SULAR_00995 2.543e-128 412.0 COG1014@1|root,COG1014@2|Bacteria 2|Bacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR CMS2_k127_1025566_14 1165841.SULAR_01000 4.306e-41 151.0 COG1144@1|root,COG1144@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor forE - 1.2.7.1 ko:K00171,ko:K00172,ko:K02573,ko:K13795,ko:K18930 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4,Fer4_21,Fer4_4,Fer4_7,POR CMS2_k127_1025566_0 1165841.SULAR_01005 1.349e-212 666.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2YMFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N CMS2_k127_1025566_5 1165841.SULAR_01010 2.439e-100 331.0 COG4886@1|root,COG4886@2|Bacteria,1Q94S@1224|Proteobacteria,42X59@68525|delta/epsilon subdivisions,2YQUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KLT COG4886 Leucine-rich repeat (LRR) protein - - - - - - - - - - - - LRR_4,LRR_8,Pkinase CMS2_k127_1025566_9 1165841.SULAR_01015 1.605e-60 212.0 COG2346@1|root,COG2346@2|Bacteria,1MZSM@1224|Proteobacteria,42S0I@68525|delta/epsilon subdivisions,2YPBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG2346, Truncated hemoglobins ctb - - ko:K06886 - - - - ko00000 - - - Bac_globin CMS2_k127_1025566_10 1165841.SULAR_00965 1.576e-56 201.0 2EKI4@1|root,33E83@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_1025566_15 1165841.SULAR_00965 1.526e-14 77.0 2EKI4@1|root,33E83@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_1025566_6 1165841.SULAR_00955 6.771e-78 261.0 COG2258@1|root,COG2258@2|Bacteria 2|Bacteria C MOSC domain - - - - - - - - - - - - MOSC CMS2_k127_1025566_12 1165841.SULAR_01065 2.957e-46 169.0 2BTTK@1|root,32P16@2|Bacteria,1Q41F@1224|Proteobacteria,42Y3I@68525|delta/epsilon subdivisions,2YQQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1025566_11 1165841.SULAR_01025 1.261e-55 198.0 COG1413@1|root,COG1413@2|Bacteria,1NMDT@1224|Proteobacteria,42WYR@68525|delta/epsilon subdivisions,2YQSX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C lyase activity - - - - - - - - - - - - - CMS2_k127_1025566_1 563040.Saut_0192 1.019e-179 574.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2YMF8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF CMS2_k127_1025566_17 243924.LT42_04620 3.124e-06 57.0 2DN52@1|root,32VJD@2|Bacteria,1N1NP@1224|Proteobacteria,1T64Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3313) - - - - - - - - - - - - DUF3313 CMS2_k127_1025566_2 929558.SMGD1_1009 8.868e-149 473.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2YMUY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG CMS2_k127_1031209_0 112098.XP_008613840.1 4.805e-11 64.0 KOG3378@1|root,KOG3378@2759|Eukaryota 2759|Eukaryota C oxygen carrier activity HBQ1 GO:0000166,GO:0001505,GO:0001678,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009743,GO:0009746,GO:0009749,GO:0009987,GO:0010033,GO:0010494,GO:0016491,GO:0016661,GO:0016662,GO:0016705,GO:0016708,GO:0016966,GO:0017144,GO:0019725,GO:0030447,GO:0031974,GO:0032991,GO:0033500,GO:0033554,GO:0034284,GO:0034599,GO:0034641,GO:0035770,GO:0035966,GO:0035967,GO:0036094,GO:0036464,GO:0040007,GO:0042133,GO:0042135,GO:0042221,GO:0042592,GO:0042593,GO:0042737,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044182,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046209,GO:0046210,GO:0048037,GO:0048878,GO:0050660,GO:0050662,GO:0050896,GO:0051213,GO:0051409,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051788,GO:0052173,GO:0052200,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0070458,GO:0070887,GO:0071218,GO:0071310,GO:0071322,GO:0071326,GO:0071331,GO:0071333,GO:0071500,GO:0071949,GO:0072593,GO:0075136,GO:0097159,GO:0097237,GO:0098754,GO:1901265,GO:1901363,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1990748,GO:1990904,GO:2001057 1.14.12.17,2.7.11.22 ko:K04563,ko:K05916,ko:K13822,ko:K13827 ko04011,ko04111,ko04113,ko05132,ko05143,ko05144,map04011,map04111,map04113,map05132,map05143,map05144 M00692,M00693 - - ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - FAD_binding_6,Globin,NAD_binding_1 CMS2_k127_1056504_14 1249480.B649_10790 1.431e-53 190.0 COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,42SE0@68525|delta/epsilon subdivisions,2YPJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx CMS2_k127_1056504_18 1249480.B649_04575 2.52e-41 154.0 2AK97@1|root,31AZH@2|Bacteria,1Q6KT@1224|Proteobacteria,433CI@68525|delta/epsilon subdivisions,2YSTQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1056504_21 572480.Arnit_2893 7.38e-27 114.0 COG0607@1|root,COG0607@2|Bacteria,1PEYP@1224|Proteobacteria,42WCJ@68525|delta/epsilon subdivisions,2YQA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese CMS2_k127_1056504_2 929558.SMGD1_2449 1.358e-235 749.0 COG2203@1|root,COG3829@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG5001@2|Bacteria,1PGYK@1224|Proteobacteria,42YPW@68525|delta/epsilon subdivisions,2YR2J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_9 CMS2_k127_1056504_7 709032.Sulku_1652 1.792e-108 357.0 COG0656@1|root,COG0656@2|Bacteria,1PGB3@1224|Proteobacteria,42PPT@68525|delta/epsilon subdivisions,2YN3U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red CMS2_k127_1056504_6 1123326.JFBL01000008_gene528 7.87e-113 365.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2YMW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Alkyl hydroperoxide reductase ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA CMS2_k127_1056504_5 709032.Sulku_1540 4.801e-166 530.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,42QJ2@68525|delta/epsilon subdivisions,2YNBV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG3864 conserved - - - - - - - - - - - - DUF2201,DUF2201_N CMS2_k127_1056504_4 1249480.B649_06825 1.447e-170 540.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42QA8@68525|delta/epsilon subdivisions,2YNH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,AAA_3 CMS2_k127_1056504_10 1198232.CYCME_0494 9.336e-65 229.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,460EZ@72273|Thiotrichales 72273|Thiotrichales S Uncharacterised protein family (UPF0014) - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 CMS2_k127_1056504_12 1249480.B649_04470 1.846e-61 218.0 COG0454@1|root,COG0456@2|Bacteria,1Q5DX@1224|Proteobacteria,4313C@68525|delta/epsilon subdivisions,2YSF5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K acetyltransferase - - - - - - - - - - - - - CMS2_k127_1056504_20 990073.ATHU01000001_gene1764 1.179e-37 147.0 COG0666@1|root,COG0666@2|Bacteria,1Q4NQ@1224|Proteobacteria,42VS5@68525|delta/epsilon subdivisions,2YQIE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ankyrin repeat - - - - - - - - - - - - Ank_4 CMS2_k127_1056504_1 1123326.JFBL01000001_gene1371 9.172e-261 815.0 COG0004@1|root,COG2199@1|root,COG0004@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43D4C@68525|delta/epsilon subdivisions 1224|Proteobacteria PT Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,GGDEF,NMT1,SBP_bac_3 CMS2_k127_1056504_11 1249480.B649_04470 6.286e-63 224.0 COG0454@1|root,COG0456@2|Bacteria,1Q5DX@1224|Proteobacteria,4313C@68525|delta/epsilon subdivisions,2YSF5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K acetyltransferase - - - - - - - - - - - - - CMS2_k127_1056504_0 1537917.JU82_01520 2.435e-263 814.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,42M5T@68525|delta/epsilon subdivisions,2YNN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cofactor biosynthesis protein NifE - - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro CMS2_k127_1056504_3 709032.Sulku_1297 1.974e-210 661.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,42P89@68525|delta/epsilon subdivisions,2YN9D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NifD NifK NifE NifN family - - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro CMS2_k127_1056504_13 1249480.B649_06990 2.757e-59 209.0 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,42W01@68525|delta/epsilon subdivisions,2YQEH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Dinitrogenase iron-molybdenum cofactor biosynthesis protein - - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co CMS2_k127_1056504_9 990073.ATHU01000001_gene1794 1.439e-67 232.0 2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,42TEY@68525|delta/epsilon subdivisions,2YPN1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nitrogen fixation protein - - - - - - - - - - - - DUF269 CMS2_k127_1056504_8 990073.ATHU01000001_gene1795 7.538e-82 274.0 COG0716@1|root,COG0716@2|Bacteria,1QRBW@1224|Proteobacteria,43ACU@68525|delta/epsilon subdivisions,2YT0R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Low-potential electron donor to a number of redox enzymes - - - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 CMS2_k127_1056504_16 1249480.B649_06975 6.271e-53 189.0 2E67S@1|root,32Q79@2|Bacteria,1N05A@1224|Proteobacteria,42X30@68525|delta/epsilon subdivisions,2YQVD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nitrogen fixation protein NifW - - - ko:K02595 - - - - ko00000 - - - NifW CMS2_k127_1056504_23 273121.WS1383 6.944e-19 91.0 COG0760@1|root,COG0760@2|Bacteria,1QUCX@1224|Proteobacteria,42VM2@68525|delta/epsilon subdivisions,2YQCT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O NifZ domain - - - ko:K02597 - - - - ko00000 - - - NifZ CMS2_k127_1056504_15 990073.ATHU01000001_gene1798 4.969e-53 189.0 COG0633@1|root,COG0633@2|Bacteria,1PSR6@1224|Proteobacteria,42XGK@68525|delta/epsilon subdivisions,2YQWI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - Fer2 CMS2_k127_1056504_17 709032.Sulku_1304 1.086e-49 177.0 COG0633@1|root,COG0633@2|Bacteria,1NJF0@1224|Proteobacteria,42U1V@68525|delta/epsilon subdivisions,2YQ25@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - Fer2 CMS2_k127_1064556_19 929558.SMGD1_1898 1.207e-14 74.0 COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,42WSU@68525|delta/epsilon subdivisions,2YQ70@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 CMS2_k127_1064556_13 929558.SMGD1_2289 1.66e-57 208.0 COG1739@1|root,COG1739@2|Bacteria,1NFJC@1224|Proteobacteria,42T7W@68525|delta/epsilon subdivisions,2YPM6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S hmm pf01205 - - - - - - - - - - - - DUF1949,UPF0029 CMS2_k127_1064556_4 709032.Sulku_0773 3.663e-111 367.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2YN5V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L a g-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 CMS2_k127_1064556_15 563040.Saut_1045 3.133e-49 192.0 28HEC@1|root,2Z7QS@2|Bacteria,1QGH3@1224|Proteobacteria,42WU7@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_1064556_16 1172190.M947_09060 9.372e-37 143.0 2AYIJ@1|root,319EA@2|Bacteria,1Q2GZ@1224|Proteobacteria,42VPA@68525|delta/epsilon subdivisions,2YQB9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1064556_18 1537915.JU57_02410 5.844e-28 116.0 COG0607@1|root,COG0607@2|Bacteria,1R70B@1224|Proteobacteria,42UX5@68525|delta/epsilon subdivisions,2YPT0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese-like domain - - - - - - - - - - - - Rhodanese CMS2_k127_1064556_9 929558.SMGD1_2423 3.073e-71 258.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43AD8@68525|delta/epsilon subdivisions 1224|Proteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,DUF3365,HATPase_c,HisKA,NMT1,PAS,PAS_3,PAS_9,PilJ,Response_reg,SBP_bac_3 CMS2_k127_1064556_2 929558.SMGD1_2285 1.208e-128 414.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,42MMC@68525|delta/epsilon subdivisions,2YMS8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the TtcA family ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 CMS2_k127_1064556_5 563040.Saut_0788 1.192e-107 352.0 COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,42MBG@68525|delta/epsilon subdivisions,2YMHE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively pfs - 3.2.2.30,3.2.2.9 ko:K18284 ko00130,ko00270,ko01100,ko01110,ko01230,map00130,map00270,map01100,map01110,map01230 M00034,M00609 R00194,R01401,R10668 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 CMS2_k127_1064556_6 1537917.JU82_04700 9.673e-85 287.0 COG0388@1|root,COG0388@2|Bacteria,1RIQI@1224|Proteobacteria,42T6J@68525|delta/epsilon subdivisions,2YP46@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - CN_hydrolase CMS2_k127_1064556_1 929558.SMGD1_2282 1.918e-129 419.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2YMWK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I malonyl coa-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 CMS2_k127_1064556_10 326298.Suden_1394 8.467e-70 245.0 COG2204@1|root,COG2204@2|Bacteria,1QASN@1224|Proteobacteria,42RV2@68525|delta/epsilon subdivisions,2YP76@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Sigma54_activ_2,Sigma54_activat CMS2_k127_1064556_8 1249480.B649_08250 6.306e-73 248.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2YP49@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidyl-prolyl cis-trans isomerase slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C CMS2_k127_1064556_14 563040.Saut_0436 9.406e-52 196.0 COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,42Q98@68525|delta/epsilon subdivisions,2YPXX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2219 CMS2_k127_1064556_11 929558.SMGD1_2279 3.14e-69 244.0 COG1729@1|root,COG1729@2|Bacteria,1NG81@1224|Proteobacteria,42R1Z@68525|delta/epsilon subdivisions,2YNY7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S repeat protein ybgF - - - - - - - - - - - TPR_16,TPR_2,TPR_6 CMS2_k127_1064556_12 1172190.M947_09090 2.513e-61 216.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2YNYJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA CMS2_k127_1064556_7 1117647.M5M_18165 2.638e-75 259.0 28I6Z@1|root,2Z89U@2|Bacteria,1R8YM@1224|Proteobacteria,1S0GG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - CMS2_k127_1064556_3 1121935.AQXX01000142_gene2326 2.19e-116 393.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria,1RSAN@1236|Gammaproteobacteria,1XNEQ@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - CMS2_k127_1064556_17 929558.SMGD1_0966 1.096e-28 118.0 COG1605@1|root,COG1605@2|Bacteria,1N6UE@1224|Proteobacteria,42UUU@68525|delta/epsilon subdivisions,2YQ49@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Chorismate mutase - - 4.2.99.21 ko:K04782 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R06602 RC01549,RC02148 ko00000,ko00001,ko01000 - - - CM_2 CMS2_k127_1064556_0 563040.Saut_0070 4.153e-151 483.0 COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,42N2D@68525|delta/epsilon subdivisions,2YNAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM CMS2_k127_1067711_0 563040.Saut_0114 2.511e-177 562.0 COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,42P5E@68525|delta/epsilon subdivisions,2YN01@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Fad-dependent pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS2_k127_1067711_1 1249480.B649_04885 1.525e-23 102.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2YNP4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind CMS2_k127_1086071_46 525898.Sdel_0911 4.975e-24 106.0 2CBEP@1|root,32RT7@2|Bacteria,1MZXD@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_1086071_17 1165841.SULAR_10094 6.58e-112 368.0 COG1999@1|root,COG1999@2|Bacteria,1R9EM@1224|Proteobacteria,42N5F@68525|delta/epsilon subdivisions 1224|Proteobacteria S protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems sco - - ko:K07152 - - - - ko00000,ko03029 - - - - CMS2_k127_1086071_2 1165841.SULAR_10089 0.0 1016.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions 1224|Proteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 CMS2_k127_1086071_12 1165841.SULAR_10084 3.385e-122 394.0 COG1845@1|root,COG1845@2|Bacteria,1RI5A@1224|Proteobacteria,43B3F@68525|delta/epsilon subdivisions 1224|Proteobacteria C Cytochrome c oxidase subunit III coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 CMS2_k127_1086071_5 1165841.SULAR_10074 3.279e-196 617.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions 1224|Proteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.10.3.10,1.9.3.1 ko:K02275,ko:K02297 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6 - - COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3 CMS2_k127_1086071_13 1165841.SULAR_10069 1.654e-121 395.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,42TVJ@68525|delta/epsilon subdivisions 1224|Proteobacteria H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - iJN746.PP_0110,iSFxv_1172.SFxv_0410 UbiA CMS2_k127_1086071_37 1165841.SULAR_03242 2.273e-43 161.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,42TMC@68525|delta/epsilon subdivisions,2YPSJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FG (HIT) family - - - - - - - - - - - - HIT CMS2_k127_1086071_4 1249480.B649_10220 1.327e-202 642.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YMN1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DEAD box helicase family deaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C CMS2_k127_1086071_11 1249480.B649_02735 7.502e-133 437.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,42NDS@68525|delta/epsilon subdivisions,2YN0K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DNA recombination protein rmuC - - ko:K09760 - - - - ko00000 - - - RmuC CMS2_k127_1086071_14 929558.SMGD1_1765 1.076e-120 410.0 COG4191@1|root,COG4564@1|root,COG4191@2|Bacteria,COG4564@2|Bacteria,1QU1X@1224|Proteobacteria 1224|Proteobacteria T Cache domain - - 2.7.13.3 ko:K02480,ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko01001,ko02022,ko02035 - - - HAMP,HATPase_c,dCache_2,sCache_2 CMS2_k127_1086071_40 1121459.AQXE01000005_gene1507 2.451e-34 143.0 COG2199@1|root,COG3706@2|Bacteria,1MXBG@1224|Proteobacteria,42NGW@68525|delta/epsilon subdivisions,2X6BI@28221|Deltaproteobacteria,2MH1N@213115|Desulfovibrionales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg CMS2_k127_1086071_26 929558.SMGD1_1770 2.084e-93 312.0 COG0745@1|root,COG0745@2|Bacteria,1PFKD@1224|Proteobacteria,42TIQ@68525|delta/epsilon subdivisions,2YPWE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_1086071_30 493475.GARC_0355 2.501e-68 241.0 COG3503@1|root,COG3503@2|Bacteria,1RA1Q@1224|Proteobacteria,1SAPP@1236|Gammaproteobacteria,469R6@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1624) - - - - - - - - - - - - DUF1624 CMS2_k127_1086071_34 387093.SUN_0768 1.868e-59 212.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,42TRT@68525|delta/epsilon subdivisions,2YPV7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C CMS2_k127_1086071_47 709032.Sulku_2257 4.169e-22 109.0 COG0642@1|root,COG2205@2|Bacteria,1Q179@1224|Proteobacteria,4313A@68525|delta/epsilon subdivisions,2YS9S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - - CMS2_k127_1086071_49 1165841.SULAR_03442 8.404e-10 63.0 2AK15@1|root,31AQQ@2|Bacteria,1Q5Z2@1224|Proteobacteria,43242@68525|delta/epsilon subdivisions,2YSUZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1086071_19 326298.Suden_1088 4.344e-106 347.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2YPCE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid CMS2_k127_1086071_44 1202532.FF52_05545 2.411e-26 116.0 COG2755@1|root,COG2755@2|Bacteria,4NPB3@976|Bacteroidetes,1I1BB@117743|Flavobacteriia,2NZXW@237|Flavobacterium 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase estA - - - - - - - - - - - Lipase_GDSL_2 CMS2_k127_1086071_28 929558.SMGD1_1778 9.799e-78 263.0 COG1183@1|root,COG1183@2|Bacteria,1MYK9@1224|Proteobacteria,42RFD@68525|delta/epsilon subdivisions,2YP9Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf CMS2_k127_1086071_22 709032.Sulku_0551 1.044e-101 345.0 COG3203@1|root,COG3203@2|Bacteria,1QZ2J@1224|Proteobacteria,42UFK@68525|delta/epsilon subdivisions,2YQ0J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M outer membrane porin, OprD family - - - - - - - - - - - - OprD CMS2_k127_1086071_9 1123326.JFBL01000013_gene330 1.611e-142 469.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42S06@68525|delta/epsilon subdivisions 1224|Proteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1,dCache_2 CMS2_k127_1086071_48 563040.Saut_0524 2.344e-18 87.0 COG1918@1|root,COG1918@2|Bacteria,1Q53C@1224|Proteobacteria,42X0A@68525|delta/epsilon subdivisions 1224|Proteobacteria P Fe2 transport system protein A feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA CMS2_k127_1086071_1 929558.SMGD1_1781 0.0 1086.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2YMB3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system feoB1 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate CMS2_k127_1086071_18 1537917.JU82_03270 4.168e-106 347.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,42MG4@68525|delta/epsilon subdivisions,2YME4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K response regulator cprR - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C CMS2_k127_1086071_21 563040.Saut_0527 3.225e-102 347.0 COG0642@1|root,COG0642@2|Bacteria,1N5IQ@1224|Proteobacteria,42M9P@68525|delta/epsilon subdivisions,2YN0U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase cprS - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA CMS2_k127_1086071_41 1150621.SMUL_0162 3.813e-32 140.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2YMW5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_2 CMS2_k127_1086071_16 1249480.B649_02785 1.353e-112 368.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2YMW1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE CMS2_k127_1086071_25 929558.SMGD1_0616 5.04e-94 312.0 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,42PHC@68525|delta/epsilon subdivisions,2YNF2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H involved in molybdopterin and thiamine biosynthesis family 1 - - - - - - - - - - - - ThiF CMS2_k127_1086071_32 373994.Riv7116_5795 2.272e-67 245.0 COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,1G3NB@1117|Cyanobacteria,1HMXB@1161|Nostocales 1117|Cyanobacteria O PFAM AhpC TSA family - - - - - - - - - - - - AhpC-TSA,NHL,Thioredoxin_8 CMS2_k127_1086071_15 360106.CFF8240_0326 5.327e-113 375.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2YN2K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iIT341.HP0867 LpxB CMS2_k127_1086071_6 1278309.KB907099_gene2796 1.029e-187 595.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1XHC5@135619|Oceanospirillales 135619|Oceanospirillales E alanine symporter dagA - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp CMS2_k127_1086071_35 936155.HFELIS_10270 4.079e-56 200.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,42SDX@68525|delta/epsilon subdivisions,2YP47@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N CMS2_k127_1086071_8 326298.Suden_1533 1.099e-144 465.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2YMPS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC CMS2_k127_1086071_33 709032.Sulku_0564 6.687e-66 233.0 COG2908@1|root,COG2908@2|Bacteria,1Q1QY@1224|Proteobacteria,42STS@68525|delta/epsilon subdivisions,2YP6A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos CMS2_k127_1086071_7 1249480.B649_02820 1.183e-146 469.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,42M00@68525|delta/epsilon subdivisions,2YMF1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T chemotaxis protein cheV - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg CMS2_k127_1086071_0 1249480.B649_02825 0.0 1123.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2YMB9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T chemotaxis protein cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg CMS2_k127_1086071_29 1537917.JU82_03220 5.19e-69 237.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2YP0K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW CMS2_k127_1086071_10 929558.SMGD1_1857 1.272e-139 449.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2YMCA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Methylenetetrahydrofolate reductase metF - - - - - - - - - - - MTHFR CMS2_k127_1086071_20 1537917.JU82_03460 6.697e-104 340.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,42NIR@68525|delta/epsilon subdivisions,2YNHV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E phosphoserine phosphatase serB - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD,Hydrolase CMS2_k127_1086071_50 709032.Sulku_1885 6.803e-07 55.0 2AK8C@1|root,31AYM@2|Bacteria,1Q6J3@1224|Proteobacteria,43398@68525|delta/epsilon subdivisions,2YSRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1086071_38 1537917.JU82_03470 3.54e-38 145.0 28QM5@1|root,319KE@2|Bacteria,1Q3DZ@1224|Proteobacteria,42X5X@68525|delta/epsilon subdivisions,2YQT9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - Cytochrome_CBB3 CMS2_k127_1086071_24 929558.SMGD1_1860 8.574e-98 341.0 COG2885@1|root,COG2885@2|Bacteria,1R9HA@1224|Proteobacteria,42T44@68525|delta/epsilon subdivisions,2YQQI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M OmpA family - - - - - - - - - - - - OmpA CMS2_k127_1086071_45 5722.XP_001321090.1 1.277e-25 121.0 COG0666@1|root,KOG4177@2759|Eukaryota 5722.XP_001321090.1|- I spectrin binding - - - - - - - - - - - - - CMS2_k127_1086071_39 1537917.JU82_05945 5.094e-37 141.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2YPHN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 CMS2_k127_1086071_31 563040.Saut_1711 1.273e-67 234.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42RN6@68525|delta/epsilon subdivisions,2YP9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB CMS2_k127_1086071_36 1537917.JU82_05935 1.646e-44 166.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,42TJR@68525|delta/epsilon subdivisions,2YPZ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 CMS2_k127_1086071_23 709032.Sulku_0674 1.485e-100 338.0 COG1466@1|root,COG1466@2|Bacteria,1RHE9@1224|Proteobacteria,42RI9@68525|delta/epsilon subdivisions,2YP40@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase III - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta CMS2_k127_1086071_3 1249480.B649_03400 3.515e-217 692.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2YMZZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Ribonuclease rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB CMS2_k127_1086071_27 929558.SMGD1_1909 5.698e-89 302.0 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2YMRX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Signal transduction protein - - - - - - - - - - - - HDOD CMS2_k127_1087156_10 1537917.JU82_08425 6.869e-33 129.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2YPT9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 CMS2_k127_1087156_0 563040.Saut_0657 2.115e-274 852.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2YMA3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 CMS2_k127_1087156_6 709032.Sulku_0369 5.274e-120 389.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2YMP8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP1386 Ribul_P_3_epim CMS2_k127_1087156_7 563040.Saut_0571 1.098e-74 256.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2YNYX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI CMS2_k127_1087156_8 1249480.B649_01665 1.898e-71 250.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,42MQQ@68525|delta/epsilon subdivisions,2YNAG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L dna polymerase iii dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T CMS2_k127_1087156_3 1249480.B649_01660 2.183e-161 512.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,42NC2@68525|delta/epsilon subdivisions,2YMTQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA CMS2_k127_1087156_2 1537917.JU82_04005 2.553e-223 697.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2YMR3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt CMS2_k127_1087156_9 326298.Suden_1610 5.079e-35 134.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2YPX3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding CMS2_k127_1087156_5 929558.SMGD1_0666 5.775e-127 409.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2YMN0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS2_k127_1087156_1 387093.SUN_2191 1.637e-238 745.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2YMY6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N CMS2_k127_1087156_4 929558.SMGD1_0669 8.769e-153 495.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2YMQE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 CMS2_k127_1092128_0 203124.Tery_1835 1.343e-17 96.0 COG0739@1|root,COG1566@1|root,COG1572@1|root,COG3391@1|root,COG4932@1|root,COG0739@2|Bacteria,COG1566@2|Bacteria,COG1572@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,1GPV0@1117|Cyanobacteria,1HFQY@1150|Oscillatoriales 2|Bacteria M Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family VPA1172 - 3.4.24.40 ko:K01406,ko:K13276,ko:K20276 ko01503,ko02024,map01503,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - DUF4114,DUF4842,OapA,Peptidase_M23 CMS2_k127_1105750_0 640081.Dsui_0921 6.057e-76 277.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3437@1|root,COG4251@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K11527,ko:K20973 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg CMS2_k127_1106805_38 563040.Saut_2158 3.362e-18 89.0 2BTTK@1|root,32P16@2|Bacteria,1Q41F@1224|Proteobacteria,42Y3I@68525|delta/epsilon subdivisions,2YQQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1106805_1 326298.Suden_0006 0.0 1052.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 CMS2_k127_1106805_6 709032.Sulku_0903 3.813e-181 578.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,42NTK@68525|delta/epsilon subdivisions,2YNFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 CMS2_k127_1106805_30 926692.AZYG01000064_gene967 2.522e-54 201.0 COG3735@1|root,COG3735@2|Bacteria,1V7NU@1239|Firmicutes,24IJ8@186801|Clostridia 186801|Clostridia S TraB family - - - ko:K09973 - - - - ko00000 - - - TraB CMS2_k127_1106805_4 563040.Saut_0009 6.887e-191 599.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,42ME8@68525|delta/epsilon subdivisions,2YN4W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm CMS2_k127_1106805_21 1172190.M947_02520 1.269e-78 269.0 COG0388@1|root,COG0388@2|Bacteria,1PZZZ@1224|Proteobacteria,42REP@68525|delta/epsilon subdivisions,2YP77@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - CN_hydrolase CMS2_k127_1106805_18 563040.Saut_0011 3.21e-94 312.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2YNXJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H protein-L-isoaspartate O-methyltransferase pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS2_k127_1106805_28 1537917.JU82_05085 8e-57 204.0 COG4123@1|root,COG4123@2|Bacteria,1R0S2@1224|Proteobacteria,42UPG@68525|delta/epsilon subdivisions,2YPXV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25,TehB CMS2_k127_1106805_34 598659.NAMH_0748 2.691e-28 119.0 COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,42SW5@68525|delta/epsilon subdivisions,2YPPA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Acyl-ACP thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - Acyl-ACP_TE CMS2_k127_1106805_33 1210884.HG799464_gene10378 1.317e-29 122.0 COG4270@1|root,COG4270@2|Bacteria,2J0EK@203682|Planctomycetes 203682|Planctomycetes S membrane - - - - - - - - - - - - DoxX_2 CMS2_k127_1106805_27 929558.SMGD1_0790 3.749e-57 202.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,42T4D@68525|delta/epsilon subdivisions,2YPHE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Low molecular weight phosphotyrosine protein phosphatase - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc CMS2_k127_1106805_35 398767.Glov_0494 6.367e-27 114.0 2DPB2@1|root,331BY@2|Bacteria,1NBDA@1224|Proteobacteria,42VNW@68525|delta/epsilon subdivisions,2WSXY@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1106805_32 1249480.B649_00260 1.885e-43 175.0 COG3144@1|root,COG3144@2|Bacteria,1PBUJ@1224|Proteobacteria,42VQM@68525|delta/epsilon subdivisions,2YQGT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar hook-length control protein FliK - - - - - - - - - - - - Flg_hook CMS2_k127_1106805_25 929558.SMGD1_1287 7.302e-71 245.0 COG1843@1|root,COG1843@2|Bacteria,1PQS2@1224|Proteobacteria,42TAQ@68525|delta/epsilon subdivisions,2YPFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgD,FlgD_ig CMS2_k127_1106805_14 1172190.M947_02430 8.594e-109 366.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,42MPN@68525|delta/epsilon subdivisions,2YMHV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar basal body protein flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C CMS2_k127_1106805_2 563040.Saut_0043 2.223e-228 727.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,42NGP@68525|delta/epsilon subdivisions,2YN81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar hook protein flgE flgE GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flagellin_IN,Flg_bb_rod,Flg_bbr_C CMS2_k127_1106805_7 1537917.JU82_10020 5.094e-180 569.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,42P1T@68525|delta/epsilon subdivisions,2YMMQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc CMS2_k127_1106805_36 240016.ABIZ01000001_gene5853 1.915e-26 115.0 COG2258@1|root,COG2258@2|Bacteria,46VBP@74201|Verrucomicrobia,2IUHR@203494|Verrucomicrobiae 203494|Verrucomicrobiae S MOSC domain - - - - - - - - - - - - - CMS2_k127_1106805_8 1278307.KB907019_gene907 9.656e-169 532.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,2QHJU@267894|Psychromonadaceae 1236|Gammaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046385,GO:0046483,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt CMS2_k127_1106805_26 1122134.KB893650_gene529 2.724e-66 230.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1XKE3@135619|Oceanospirillales 135619|Oceanospirillales H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 CMS2_k127_1106805_23 563040.Saut_2165 3.893e-75 255.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,42QPX@68525|delta/epsilon subdivisions,2YNW3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC CMS2_k127_1106805_3 1537917.JU82_05035 2.97e-197 623.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2YM88@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N CMS2_k127_1106805_10 929558.SMGD1_1248 9.954e-150 481.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2YM9J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 CMS2_k127_1106805_0 326298.Suden_0003 0.0 1242.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2YMUW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim CMS2_k127_1106805_19 563040.Saut_0004 1.639e-84 298.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,42M47@68525|delta/epsilon subdivisions,2YMRS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T (EAL) domain protein - - - - - - - - - - - - EAL,GGDEF CMS2_k127_1106805_24 326298.Suden_0004 5.563e-72 243.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,42RDZ@68525|delta/epsilon subdivisions,2YP5I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF CMS2_k127_1106805_31 387093.SUN_1044 3.18e-52 189.0 COG3216@1|root,COG3216@2|Bacteria,1PSZW@1224|Proteobacteria,42SRF@68525|delta/epsilon subdivisions,2YPQA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K09928 - - - - ko00000 - - - DUF2062 CMS2_k127_1106805_12 572480.Arnit_0649 3.373e-130 430.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2YMGU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H tRNA nucleotidyltransferase poly(A) polymerase cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd CMS2_k127_1106805_29 1165841.SULAR_03427 1.53e-55 199.0 COG4902@1|root,COG4902@2|Bacteria 2|Bacteria - - - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - DUF2202 CMS2_k127_1106805_11 709032.Sulku_0006 1.28e-142 455.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2YMQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran CMS2_k127_1106805_15 387092.NIS_0585 6.925e-104 345.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2YMIH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 CMS2_k127_1106805_13 929558.SMGD1_1614 1.859e-124 404.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2YN3F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 CMS2_k127_1106805_16 929558.SMGD1_1894 8.406e-103 338.0 COG0778@1|root,COG0778@2|Bacteria,1MWMJ@1224|Proteobacteria,43AM8@68525|delta/epsilon subdivisions,2YS31@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase CMS2_k127_1106805_5 1442598.JABW01000031_gene1280 8.241e-191 617.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YNJ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF CMS2_k127_1106805_17 1168067.JAGP01000001_gene568 1.457e-99 336.0 COG0715@1|root,COG0715@2|Bacteria,1NV0U@1224|Proteobacteria,1SNZC@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - - CMS2_k127_1106805_9 1249480.B649_00090 5.995e-159 514.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ7@1224|Proteobacteria,43BJF@68525|delta/epsilon subdivisions,2YNM7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,sCache_like CMS2_k127_1106805_20 1123326.JFBL01000003_gene1964 5.313e-81 278.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42PA1@68525|delta/epsilon subdivisions,2YNMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_1106805_22 1537917.JU82_02990 4.909e-78 266.0 COG0704@1|root,COG0704@2|Bacteria,1Q5TJ@1224|Proteobacteria,42STN@68525|delta/epsilon subdivisions,2YPRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P PhoU family - - - ko:K02039 - - - - ko00000 - - - PhoU CMS2_k127_1106805_37 1537917.JU82_02995 2.562e-22 97.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2YMMK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 CMS2_k127_1129642_2 1249480.B649_06615 4.289e-133 428.0 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,42Z77@68525|delta/epsilon subdivisions,2YRAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 CMS2_k127_1129642_3 1249480.B649_06610 3.316e-45 169.0 COG2077@1|root,COG2077@2|Bacteria,1Q5Y2@1224|Proteobacteria,4321Y@68525|delta/epsilon subdivisions,2YS92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides - - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - - CMS2_k127_1129642_0 709032.Sulku_1510 5.873e-269 832.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,42MHB@68525|delta/epsilon subdivisions,2YNUZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase cofactor biosynthesis protein NifB - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM CMS2_k127_1129642_1 1249480.B649_06590 1.211e-163 523.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YNBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like CMS2_k127_1142101_0 7029.ACYPI32242-PA 5.663e-18 93.0 2CY95@1|root,2S2X3@2759|Eukaryota,3A4AR@33154|Opisthokonta,3BRVC@33208|Metazoa,3D8TC@33213|Bilateria,422C0@6656|Arthropoda,3SR3A@50557|Insecta 33208|Metazoa S ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595 CMS2_k127_1142101_1 164328.Phyra82942 6.796e-06 55.0 KOG3105@1|root,KOG3105@2759|Eukaryota,3QG87@4776|Peronosporales 4776|Peronosporales S DNA binding - - - - - - - - - - - - - CMS2_k127_1157217_0 326298.Suden_1566 3.811e-293 917.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2YMGZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF CMS2_k127_1157217_4 1172190.M947_04705 2.545e-26 113.0 COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,42V9C@68525|delta/epsilon subdivisions,2YQ7A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin CMS2_k127_1157217_3 929558.SMGD1_0638 6.584e-116 382.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2YT0U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases tagE - - - - - - - - - - - Peptidase_M23 CMS2_k127_1157217_2 563040.Saut_0590 2.285e-121 400.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2YMRG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H folylpolyglutamate synthase folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M CMS2_k127_1157217_1 563040.Saut_0589 1.171e-152 497.0 COG1511@1|root,COG2199@1|root,COG1511@2|Bacteria,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,42M6B@68525|delta/epsilon subdivisions,2YN3C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF CMS2_k127_1171612_0 357804.Ping_2678 1.467e-204 645.0 COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,1RNYZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - DUF2254 CMS2_k127_1171612_4 314345.SPV1_00987 6.341e-27 111.0 2DPGY@1|root,3320R@2|Bacteria,1ND7F@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3185) - - - - - - - - - - - - DUF3185 CMS2_k127_1171612_3 314345.SPV1_00982 7.968e-32 125.0 COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria 1224|Proteobacteria S PFAM Transglycosylase-associated protein MA20_01300 - - - - - - - - - - - Transgly_assoc CMS2_k127_1171612_1 929558.SMGD1_0227 9.664e-142 452.0 28HKZ@1|root,2Z7VP@2|Bacteria,1R4QW@1224|Proteobacteria,42T37@68525|delta/epsilon subdivisions,2YR4U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3050) - - - - - - - - - - - - DUF3050 CMS2_k127_1171612_2 1249480.B649_06960 1.482e-113 369.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2YNGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD CMS2_k127_1174047_3 1249480.B649_10090 1.573e-117 385.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2YME1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M heptosyltransferase ii waaF - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 CMS2_k127_1174047_7 1249480.B649_10095 3.86e-39 153.0 2ANX8@1|root,31DXW@2|Bacteria,1QB8A@1224|Proteobacteria,42WEI@68525|delta/epsilon subdivisions,2YQAD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - YfaZ CMS2_k127_1174047_1 563040.Saut_1568 1.308e-200 634.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2YMZG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB CMS2_k127_1174047_2 563040.Saut_1569 4.274e-182 573.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,42MC1@68525|delta/epsilon subdivisions,2YMD0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M ADP-L-glycero-D-manno-heptose-6-epimerase waaD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase CMS2_k127_1174047_8 273121.WS0700 3.104e-28 116.0 COG2863@1|root,COG2863@2|Bacteria,1PDTH@1224|Proteobacteria,42W2E@68525|delta/epsilon subdivisions,2YQDN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c553 cccA - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 CMS2_k127_1174047_5 103690.17129971 1.215e-46 175.0 COG2227@1|root,COG2227@2|Bacteria,1G25I@1117|Cyanobacteria,1HNR6@1161|Nostocales 1117|Cyanobacteria H Thiopurine S-methyltransferase (TPMT) - - - - - - - - - - - - Methyltransf_11,TPMT CMS2_k127_1174047_10 1172190.M947_10165 4.758e-16 79.0 COG3197@1|root,COG3197@2|Bacteria,1NEH5@1224|Proteobacteria,42VDQ@68525|delta/epsilon subdivisions,2YQ99@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Cytochrome oxidase maturation protein ccoS - - - - - - - - - - - FixS CMS2_k127_1174047_0 709032.Sulku_2147 0.0 1019.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2YMI5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P cation transport ATPase ccoI - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase CMS2_k127_1174047_6 572480.Arnit_1201 6.662e-46 170.0 COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2YQ20@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EJ GlutRNAGln amidotransferase subunit D - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase CMS2_k127_1174047_4 1172190.M947_10180 7.509e-63 220.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2YPEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E D,D-heptose 1,7-bisphosphate phosphatase gmhB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - iIT341.HP0860 HAD_2,Hydrolase_like,PNK3P CMS2_k127_1174047_9 929558.SMGD1_1943 1.916e-26 108.0 COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,42QUT@68525|delta/epsilon subdivisions,2YNVS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 CMS2_k127_1174299_0 326298.Suden_0081 1.883e-257 799.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2YMGW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - iIT341.HP0144 COX1 CMS2_k127_1174299_12 387093.SUN_1261 1.676e-57 209.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,42Q44@68525|delta/epsilon subdivisions,2YNTJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 CMS2_k127_1174299_2 709032.Sulku_2351 5.621e-196 616.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2YMKQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase CMS2_k127_1174299_8 563040.Saut_1967 5.283e-75 257.0 COG2952@1|root,COG2952@2|Bacteria,1PBRU@1224|Proteobacteria,42MEP@68525|delta/epsilon subdivisions,2YN8A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K09804 - - - - ko00000 - - - DUF507 CMS2_k127_1174299_5 572480.Arnit_0905 6.512e-152 486.0 COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2YM84@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterised conserved protein (DUF2156) - - - ko:K01163 - - - - ko00000 - - - DUF2156 CMS2_k127_1174299_15 326298.Suden_1201 6.484e-29 121.0 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,42U84@68525|delta/epsilon subdivisions,2YPVG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 CMS2_k127_1174299_10 929558.SMGD1_1850 5.379e-73 253.0 2BVAM@1|root,32QQF@2|Bacteria,1Q4S6@1224|Proteobacteria,42ZRM@68525|delta/epsilon subdivisions,2YRRP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1174299_14 929558.SMGD1_1510 4.254e-39 151.0 COG3334@1|root,COG3334@2|Bacteria,1Q9SM@1224|Proteobacteria,42TJV@68525|delta/epsilon subdivisions,2YPUS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PDP protein - - - - - - - - - - - - MgtE_N CMS2_k127_1174299_16 1172190.M947_05905 1.752e-16 85.0 2AIVF@1|root,319NT@2|Bacteria,1Q3D4@1224|Proteobacteria,42X4I@68525|delta/epsilon subdivisions,2YQUS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Flagellar FliJ protein - - - - - - - - - - - - FliJ CMS2_k127_1174299_1 709032.Sulku_2355 2.615e-221 691.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2YMCM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt CMS2_k127_1174299_6 929558.SMGD1_1507 1.536e-113 372.0 COG0124@1|root,COG0124@2|Bacteria,1QUJQ@1224|Proteobacteria,42NX2@68525|delta/epsilon subdivisions,2YN2F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J PFAM tRNA synthetase class II (G H P and S) hisZ - - - - - - - - - - - tRNA-synt_His CMS2_k127_1174299_4 387093.SUN_0172 8.138e-182 574.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2YN1J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase - - - - - - - - - - - - Aminotran_5 CMS2_k127_1174299_9 357804.Ping_2544 1.767e-73 254.0 COG0500@1|root,COG2226@2|Bacteria,1N0SX@1224|Proteobacteria 1224|Proteobacteria Q PFAM Methyltransferase type - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 CMS2_k127_1174299_13 1537915.JU57_06865 2.93e-39 153.0 COG4238@1|root,COG4238@2|Bacteria,1N4E5@1224|Proteobacteria,42USX@68525|delta/epsilon subdivisions,2YQ09@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M major outer membrane lipoprotein - - - - - - - - - - - - - CMS2_k127_1174299_11 273121.WS1290 8.478e-71 248.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2YMDK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA CMS2_k127_1174299_7 563040.Saut_1974 1.092e-80 273.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,42NGT@68525|delta/epsilon subdivisions,2YN0R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like CMS2_k127_1174299_3 1172190.M947_05870 1.224e-194 615.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2YN8R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP transporter - - - - - - - - - - - - MFS_1,Sugar_tr CMS2_k127_1174299_17 326298.Suden_0255 1.842e-08 56.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2YMQH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin biosynthesis moeA2 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N CMS2_k127_1186798_9 1537917.JU82_03870 7.973e-34 131.0 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2YPYI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C CMS2_k127_1186798_0 1249480.B649_01525 9.61e-296 923.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2YMPF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 CMS2_k127_1186798_7 1537917.JU82_03860 1.462e-68 240.0 COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,42N60@68525|delta/epsilon subdivisions,2YMCU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S phosphoribosyltransferase - - - ko:K07100 - - - - ko00000 - - - Pribosyltran CMS2_k127_1186798_6 1537917.JU82_03855 9.906e-128 424.0 COG1463@1|root,COG1463@2|Bacteria,1RFFS@1224|Proteobacteria,42P4P@68525|delta/epsilon subdivisions,2YNNZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS2_k127_1186798_5 1172190.M947_06500 7.028e-198 641.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2YMFS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C CMS2_k127_1186798_10 1244528.CFT03427_1237 2.32e-29 122.0 COG1714@1|root,COG1714@2|Bacteria,1N7R6@1224|Proteobacteria,42U2T@68525|delta/epsilon subdivisions,2YPV6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S RDD family - - - - - - - - - - - - RDD CMS2_k127_1186798_2 1249480.B649_01505 5.994e-228 710.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2YMR4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N CMS2_k127_1186798_8 1249480.B649_01500 4.892e-42 162.0 COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,42T0U@68525|delta/epsilon subdivisions,2YPN4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Uroporphyrinogen-III synthase hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 CMS2_k127_1186798_1 572480.Arnit_2060 2.288e-250 781.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2YMV0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans CMS2_k127_1186798_3 929558.SMGD1_0803 1.291e-218 686.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2YMBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1055 Na H antiporter NhaD and related arsenite - - - - - - - - - - - - CitMHS CMS2_k127_1186798_4 1249480.B649_01465 1.642e-200 634.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2YNJC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS2_k127_1186798_11 563040.Saut_1790 4.93e-29 121.0 2ARMJ@1|root,31GY7@2|Bacteria,1QEMQ@1224|Proteobacteria,42VV2@68525|delta/epsilon subdivisions,2YQ9G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - DUF721 CMS2_k127_1186798_12 827.JFJK01000015_gene566 4.39e-22 97.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2YMVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N CMS2_k127_1190812_4 572480.Arnit_1898 3.912e-12 66.0 COG2863@1|root,COG2863@2|Bacteria,1NFMX@1224|Proteobacteria,42VGD@68525|delta/epsilon subdivisions,2YPDJ@29547|Epsilonproteobacteria 68525|delta/epsilon subdivisions C cytochrome cyf GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 CMS2_k127_1190812_1 709032.Sulku_1026 6.876e-43 162.0 2AHYJ@1|root,318BT@2|Bacteria,1Q04R@1224|Proteobacteria,42RKI@68525|delta/epsilon subdivisions,2YPAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1190812_3 574966.KB898656_gene1500 6.831e-36 138.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria,1XKPR@135619|Oceanospirillales 135619|Oceanospirillales O peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3 CMS2_k127_1190812_2 1165841.SULAR_03337 1.044e-37 162.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core,Transglut_i_TM CMS2_k127_1190812_0 1165841.SULAR_03332 3.581e-65 246.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - ko:K07184 - - - - ko00000 - - - DUF3488,Transglut_core CMS2_k127_124826_1 314285.KT71_11995 2.085e-29 124.0 COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,1J6CJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S s cog2930 CT2216 - - - - - - - - - - - Ysc84 CMS2_k127_124826_0 387093.SUN_2266 5.521e-199 633.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2YNP4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind CMS2_k127_1265963_5 1165841.SULAR_02033 2.319e-93 313.0 2A54K@1|root,30TT8@2|Bacteria,1Q98H@1224|Proteobacteria,4348V@68525|delta/epsilon subdivisions,2YRCN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1265963_9 1165841.SULAR_06683 4.208e-52 185.0 2B9KW@1|root,322Z5@2|Bacteria,1RJJB@1224|Proteobacteria,42VPQ@68525|delta/epsilon subdivisions,2YRZA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1265963_1 1165841.SULAR_01998 1.57e-204 642.0 COG0475@1|root,COG0475@2|Bacteria 2|Bacteria P glutathione-regulated potassium exporter activity - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Na_H_Exchanger CMS2_k127_1265963_8 1321778.HMPREF1982_01693 4.877e-61 225.0 COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,269C9@186813|unclassified Clostridiales 186801|Clostridia V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 CMS2_k127_1265963_7 926550.CLDAP_07690 5.376e-70 247.0 COG1131@1|root,COG1131@2|Bacteria,2G7U7@200795|Chloroflexi 200795|Chloroflexi V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_1265963_2 326298.Suden_0621 9.696e-134 432.0 COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,42PYD@68525|delta/epsilon subdivisions,2YN6I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K PFAM Bacterial transcription activator, effector binding domain - - - ko:K13652 - - - - ko00000,ko03000 - - - GyrI-like,HTH_18 CMS2_k127_1265963_0 326298.Suden_0622 3.253e-258 801.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2YMWB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Biotin carboxylase pycA - 6.3.4.14,6.4.1.1,6.4.1.2 ko:K01959,ko:K01961 ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00376,M00620 R00344,R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS2_k127_1265963_6 929558.SMGD1_2128 5.103e-73 252.0 2BNSM@1|root,32HG6@2|Bacteria,1Q1E8@1224|Proteobacteria,42TDY@68525|delta/epsilon subdivisions,2YPGN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1265963_3 1313265.JNIE01000003_gene1368 8.213e-129 419.0 COG3329@1|root,COG3329@2|Bacteria,2G4J8@200783|Aquificae 200783|Aquificae S Na+-dependent bicarbonate transporter superfamily - - - ko:K07086 - - - - ko00000 - - - Sbt_1 CMS2_k127_1265963_10 204536.SULAZ_0652 1.443e-22 100.0 COG0347@1|root,COG0347@2|Bacteria,2G58T@200783|Aquificae 200783|Aquificae K Belongs to the P(II) protein family - - - - - - - - - - - - - CMS2_k127_1265963_4 667014.Thein_0471 1.542e-109 361.0 COG0026@1|root,COG0026@2|Bacteria,2GIDQ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria F ATP-grasp domain - - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp CMS2_k127_1280931_4 929558.SMGD1_2736 2.582e-219 686.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2YM9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS2_k127_1280931_20 1249480.B649_05685 6.072e-30 121.0 COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42VGZ@68525|delta/epsilon subdivisions,2YQ8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 CMS2_k127_1280931_24 1355374.JARU01000004_gene1623 1.777e-21 101.0 2AIU4@1|root,319B6@2|Bacteria,1Q28N@1224|Proteobacteria,42V6E@68525|delta/epsilon subdivisions,2YQ6D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1280931_15 709032.Sulku_0981 3.791e-80 273.0 COG3852@1|root,COG3852@2|Bacteria,1QAGK@1224|Proteobacteria,42RSW@68525|delta/epsilon subdivisions,2YPDC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - - CMS2_k127_1280931_2 1537917.JU82_01150 3.291e-306 947.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2YMMT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 CMS2_k127_1280931_11 1249480.B649_05655 3.524e-99 333.0 COG4786@1|root,COG4786@2|Bacteria,1PZ24@1224|Proteobacteria,42NGI@68525|delta/epsilon subdivisions,2YNFE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar basal body flgG2 - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C CMS2_k127_1280931_8 929558.SMGD1_2730 1.043e-132 426.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,42N3R@68525|delta/epsilon subdivisions,2YMWT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Belongs to the flagella basal body rod proteins family flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C CMS2_k127_1280931_14 1537917.JU82_01135 1.178e-83 279.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42R6H@68525|delta/epsilon subdivisions,2YP0H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C CMS2_k127_1280931_5 709032.Sulku_0987 1.613e-199 625.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2YME5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh CMS2_k127_1280931_25 563040.Saut_1211 5.683e-20 93.0 2B0KG@1|root,31SY5@2|Bacteria,1QAAH@1224|Proteobacteria,42VV8@68525|delta/epsilon subdivisions,2YSZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1280931_9 929558.SMGD1_2723 6.096e-132 425.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,42MPM@68525|delta/epsilon subdivisions,2YMX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N CMS2_k127_1280931_16 1249480.B649_05610 2.058e-75 256.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,42RJX@68525|delta/epsilon subdivisions,2YP8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase CMS2_k127_1280931_12 709032.Sulku_0992 1.459e-97 323.0 COG2932@1|root,COG2932@2|Bacteria,1RIP6@1224|Proteobacteria,42RJG@68525|delta/epsilon subdivisions,2YP8P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K phage repressor - - - - - - - - - - - - Peptidase_S24,Phage_CI_repr CMS2_k127_1280931_7 929558.SMGD1_2720 8.03e-134 439.0 COG0791@1|root,COG0791@2|Bacteria,1R45H@1224|Proteobacteria,42NS0@68525|delta/epsilon subdivisions,2YN06@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG0791 Cell wall-associated hydrolases (invasion-associated proteins) - - - - - - - - - - - - NLPC_P60,N_NLPC_P60,Peptidase_M15_4,SH3_6,SH3_7 CMS2_k127_1280931_23 709032.Sulku_0994 3.651e-24 106.0 COG1558@1|root,COG1558@2|Bacteria,1R09B@1224|Proteobacteria 1224|Proteobacteria N Flagellar basal body rod FlgEFG protein C-terminal - - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C CMS2_k127_1280931_6 1537917.JU82_01080 1.39e-182 578.0 COG2171@1|root,COG2171@2|Bacteria,1MYKK@1224|Proteobacteria,42MHI@68525|delta/epsilon subdivisions,2YMU8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep_2,THDPS_M,THDPS_N CMS2_k127_1280931_1 1172190.M947_11450 5.34e-322 992.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42PNF@68525|delta/epsilon subdivisions,2YNCZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22348 - - - - ko00000,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 CMS2_k127_1280931_10 1172190.M947_11445 1.389e-103 340.0 COG3667@1|root,COG3667@2|Bacteria,1MXW6@1224|Proteobacteria,42SFY@68525|delta/epsilon subdivisions,2YPMX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Copper resistance protein B precursor (CopB) - - - ko:K07233 - - - - ko00000 - - - CopB CMS2_k127_1280931_3 709032.Sulku_1443 6.759e-226 705.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2YMG9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0026 Citrate_synt CMS2_k127_1280931_26 1172190.M947_00440 0.0002478 46.0 2BT0G@1|root,32N4I@2|Bacteria,1Q3JR@1224|Proteobacteria,432I1@68525|delta/epsilon subdivisions,2YSVN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1280931_13 1249480.B649_05440 3.56e-89 298.0 COG0745@1|root,COG0745@2|Bacteria,1Q4AG@1224|Proteobacteria,42YR3@68525|delta/epsilon subdivisions,2YR20@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Response regulator receiver - - - - - - - - - - - - Response_reg CMS2_k127_1280931_18 1123326.JFBL01000003_gene1893 4.566e-66 248.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions,2YMNU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,PAS,PAS_3,PAS_9 CMS2_k127_1280931_21 760154.Sulba_2111 8.093e-26 123.0 COG0582@1|root,COG0582@2|Bacteria,1NF42@1224|Proteobacteria,42TDK@68525|delta/epsilon subdivisions,2YPI2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase CMS2_k127_1280931_0 1123326.JFBL01000001_gene1363 0.0 1170.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,42MZ4@68525|delta/epsilon subdivisions,2YNF5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase CMS2_k127_1280931_19 1355368.JART01000008_gene1699 3.111e-30 119.0 COG1961@1|root,COG1961@2|Bacteria,1R3XB@1224|Proteobacteria,42UPK@68525|delta/epsilon subdivisions,2YQYC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Resolvase, N terminal domain - - - - - - - - - - - - CENP-B_N,Resolvase CMS2_k127_1280931_17 929558.SMGD1_2003 1.085e-69 237.0 COG1961@1|root,COG1961@2|Bacteria,1R3XB@1224|Proteobacteria,42UPK@68525|delta/epsilon subdivisions,2YQYC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Resolvase, N terminal domain - - - - - - - - - - - - CENP-B_N,Resolvase CMS2_k127_1304192_16 709032.Sulku_0041 6.163e-29 117.0 COG3545@1|root,COG3545@2|Bacteria,1MZB5@1224|Proteobacteria,43B8G@68525|delta/epsilon subdivisions,2YT6R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Serine hydrolase - - - ko:K07002 - - - - ko00000 - - - Ser_hydrolase CMS2_k127_1304192_4 1172190.M947_08165 9.393e-152 485.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2YMXF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 CMS2_k127_1304192_9 326298.Suden_0132 1.267e-90 299.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,42RE8@68525|delta/epsilon subdivisions,2YP3Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin CMS2_k127_1304192_12 929558.SMGD1_1357 9.665e-57 207.0 COG3637@1|root,COG3637@2|Bacteria,1R3QN@1224|Proteobacteria,42Y1W@68525|delta/epsilon subdivisions,2YQU0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - CMS2_k127_1304192_11 326298.Suden_0133 3.884e-59 213.0 COG3637@1|root,COG3637@2|Bacteria,1R3QN@1224|Proteobacteria,42Y1W@68525|delta/epsilon subdivisions,2YQU0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - CMS2_k127_1304192_8 1537917.JU82_00585 3e-93 313.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,42P86@68525|delta/epsilon subdivisions,2YN53@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - iIT341.HP1418 MurB_C CMS2_k127_1304192_15 1249480.B649_00400 1.137e-34 134.0 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,42VAB@68525|delta/epsilon subdivisions,2YPTR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar biosynthetic protein FliQ fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 CMS2_k127_1304192_6 563040.Saut_0105 6.951e-137 440.0 COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2YMNQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth CMS2_k127_1304192_2 1537917.JU82_00600 2.304e-188 592.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2YN4V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA CMS2_k127_1304192_1 326298.Suden_2001 2.735e-248 769.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2YMBY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N CMS2_k127_1304192_17 563040.Saut_0109 3.623e-18 87.0 2BRG4@1|root,32MA7@2|Bacteria,1Q36H@1224|Proteobacteria,42WUT@68525|delta/epsilon subdivisions,2YQQJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1304192_14 929558.SMGD1_1366 4.627e-43 165.0 2A50M@1|root,30TNT@2|Bacteria,1PDM4@1224|Proteobacteria,42QJ6@68525|delta/epsilon subdivisions,2YPYD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S AMIN domain - - - - - - - - - - - - AMIN CMS2_k127_1304192_13 598659.NAMH_0280 3.895e-48 177.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42RJW@68525|delta/epsilon subdivisions,2YP85@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI CMS2_k127_1304192_7 929558.SMGD1_1060 1.376e-133 436.0 COG0475@1|root,COG0475@2|Bacteria,1N2RV@1224|Proteobacteria,43B2N@68525|delta/epsilon subdivisions,2YT5E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger CMS2_k127_1304192_5 1249480.B649_00635 9.193e-139 447.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,42NGR@68525|delta/epsilon subdivisions,2YMH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM CMS2_k127_1304192_10 1249480.B649_00640 1.881e-64 224.0 COG0622@1|root,COG0622@2|Bacteria,1NPH4@1224|Proteobacteria,42TB8@68525|delta/epsilon subdivisions,2YPHV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Phosphoesterase - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 CMS2_k127_1304192_0 929558.SMGD1_1057 0.0 1139.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2YMH2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom CMS2_k127_1304192_3 598659.NAMH_1612 3.706e-152 495.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,42MX8@68525|delta/epsilon subdivisions,2YN00@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flaB GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N CMS2_k127_1339753_0 1565314.OA34_10285 1.402e-182 575.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,42P26@68525|delta/epsilon subdivisions,2YN89@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core CMS2_k127_1375469_1 929558.SMGD1_1855 5.697e-180 571.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2YMPK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b CMS2_k127_1375469_0 1172190.M947_10035 1.241e-237 740.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42M87@68525|delta/epsilon subdivisions,2YNA4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM CMS2_k127_1375469_2 1537917.JU82_00830 2.907e-90 299.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2YMPB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Glycerol-3-phosphate dehydrogenase glpC - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 CMS2_k127_1384007_14 1172190.M947_10285 2.419e-64 222.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,42MJ1@68525|delta/epsilon subdivisions,2YMZ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0212 M20_dimer,Peptidase_M20 CMS2_k127_1384007_18 929558.SMGD1_2214 4.396e-43 159.0 2B3E9@1|root,31W34@2|Bacteria,1MZ95@1224|Proteobacteria,42U85@68525|delta/epsilon subdivisions,2YQ41@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1384007_7 1165841.SULAR_06663 5.644e-154 496.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2YMYW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 CMS2_k127_1384007_10 1165841.SULAR_06668 1.766e-105 346.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2YTJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_1384007_5 1165841.SULAR_06673 4.923e-184 584.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2YMC4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_1384007_1 929558.SMGD1_2212 0.0 1437.0 COG0249@1|root,COG1403@1|root,COG0249@2|Bacteria,COG1403@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2YN6Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DNA mismatch repair MutS family mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_III,MutS_V CMS2_k127_1384007_15 1537917.JU82_04550 1.985e-63 219.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,42QQM@68525|delta/epsilon subdivisions,2YNZA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT signal transduction sensor histidine kinase - - - - - - - - - - - - PAS,PAS_3 CMS2_k127_1384007_23 1172190.M947_01505 1.014e-09 66.0 2A12A@1|root,30P83@2|Bacteria,1Q69N@1224|Proteobacteria,432PN@68525|delta/epsilon subdivisions,2YSH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1384007_22 1537917.JU82_09135 3.569e-13 68.0 COG0754@1|root,COG0754@2|Bacteria,1MW6V@1224|Proteobacteria,42N3V@68525|delta/epsilon subdivisions,2YMBJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutathionylspermidine synthase gss - - - - - - - - - - - GSP_synth CMS2_k127_1384007_24 1112217.PPL19_18312 1.913e-08 63.0 COG3637@1|root,COG3637@2|Bacteria,1RIYQ@1224|Proteobacteria 1224|Proteobacteria M membrane oprH - - - - - - - - - - - OMP_b-brl CMS2_k127_1384007_19 1396858.Q666_04395 1.53e-42 175.0 COG1470@1|root,COG1470@2|Bacteria,1QX4K@1224|Proteobacteria 1224|Proteobacteria S cell adhesion involved in biofilm formation - - - - - - - - - - - - - CMS2_k127_1384007_4 563040.Saut_1484 3.706e-186 589.0 COG0754@1|root,COG0754@2|Bacteria,1MW6V@1224|Proteobacteria,42N3V@68525|delta/epsilon subdivisions,2YMBJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutathionylspermidine synthase gss - - - - - - - - - - - GSP_synth CMS2_k127_1384007_17 929558.SMGD1_0462 1.379e-56 203.0 28WAS@1|root,2ZIB8@2|Bacteria,1NBB7@1224|Proteobacteria,42P2G@68525|delta/epsilon subdivisions,2YNQ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1384007_21 563040.Saut_1482 9.509e-36 141.0 2BURB@1|root,32Q2G@2|Bacteria,1Q8SP@1224|Proteobacteria,42XCS@68525|delta/epsilon subdivisions,2YQW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1384007_20 387092.NIS_0546 5.205e-40 153.0 COG0009@1|root,COG0009@2|Bacteria,1Q1KW@1224|Proteobacteria,42TY2@68525|delta/epsilon subdivisions,2YPSU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J L-threonylcarbamoyladenylate synthase tsaC - - - - - - - - - - - - CMS2_k127_1384007_0 1249480.B649_03510 0.0 1811.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2YMHU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS CMS2_k127_1384007_13 1249480.B649_03515 3.947e-70 245.0 COG1792@1|root,COG1792@2|Bacteria,1QB26@1224|Proteobacteria,42MF4@68525|delta/epsilon subdivisions,2YNT9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Rod shape-determining protein MreC mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC CMS2_k127_1384007_3 1172190.M947_11555 5.484e-196 614.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2YMHT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D rod shape-determining protein mreB mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl CMS2_k127_1384007_2 563040.Saut_1476 2.04e-218 683.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2YM9G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX CMS2_k127_1384007_8 563040.Saut_1475 1.385e-127 411.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2YMG4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - iIT341.HP1375 Acetyltransf_11,Hexapep CMS2_k127_1384007_12 1537917.JU82_05760 1.61e-78 263.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,42SCN@68525|delta/epsilon subdivisions,2YP5R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA CMS2_k127_1384007_16 1249480.B649_06715 2.859e-59 208.0 2BMN0@1|root,32G77@2|Bacteria,1Q0X8@1224|Proteobacteria,42SM0@68525|delta/epsilon subdivisions,2YPGW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1384007_6 563040.Saut_1473 7.134e-169 538.0 COG1636@1|root,COG1636@2|Bacteria,1MUG5@1224|Proteobacteria,42M1E@68525|delta/epsilon subdivisions,2YN69@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queH - 1.17.99.6 ko:K09765 - - - - ko00000,ko01000,ko03016 - - - DUF208 CMS2_k127_1384007_11 1249480.B649_03550 2.518e-82 275.0 COG0652@1|root,COG0652@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2YNZU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase CMS2_k127_1384007_9 1123355.JHYO01000015_gene1963 4.12e-118 404.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,36XKH@31993|Methylocystaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg CMS2_k127_1452084_0 572480.Arnit_3080 1.067e-143 465.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,42QJ2@68525|delta/epsilon subdivisions,2YNBV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG3864 conserved - - - - - - - - - - - - DUF2201,DUF2201_N CMS2_k127_1452084_2 90814.KL370891_gene1913 8.298e-19 87.0 COG5483@1|root,COG5483@2|Bacteria,1RFEQ@1224|Proteobacteria,1S49F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 CMS2_k127_1565720_2 1165841.SULAR_00540 5.96e-60 211.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,42RPS@68525|delta/epsilon subdivisions,2YP4Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N CMS2_k127_1565720_0 563040.Saut_0940 1.234e-165 541.0 COG1315@1|root,COG1315@2|Bacteria,1R5P6@1224|Proteobacteria,42MAS@68525|delta/epsilon subdivisions,2YM7Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Flagellar Assembly Protein A - - - - - - - - - - - - FapA CMS2_k127_1565720_1 1172190.M947_01105 1.936e-114 375.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2YMFV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN CMS2_k127_156967_1 326298.Suden_1826 8.375e-253 782.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2YMSC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa CMS2_k127_156967_2 1537917.JU82_10885 1.917e-122 397.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2YN6R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa CMS2_k127_156967_3 563040.Saut_1834 8.721e-101 329.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2YMUT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 CMS2_k127_156967_0 1249480.B649_01130 2.85e-266 830.0 COG0464@1|root,COG0464@2|Bacteria,1N4ZI@1224|Proteobacteria,42NGJ@68525|delta/epsilon subdivisions,2YMAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATPase (AAA - - - - - - - - - - - - AAA CMS2_k127_1615712_4 203122.Sde_1889 7.341e-24 103.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,1S416@1236|Gammaproteobacteria,46AVD@72275|Alteromonadaceae 1236|Gammaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS2_k127_1615712_0 1565314.OA34_06875 6.223e-187 593.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42PK7@68525|delta/epsilon subdivisions,2YMS5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Amidase - - 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 - R00005 RC02756 ko00000,ko00001,ko01000 - - - Amidase CMS2_k127_1615712_3 1150621.SMUL_2948 8.754e-55 195.0 COG0154@1|root,COG0154@2|Bacteria,1N1MF@1224|Proteobacteria,430HD@68525|delta/epsilon subdivisions,2YS3F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amidase activity - - 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 - R00005 RC02756 ko00000,ko00001,ko01000 - - - - CMS2_k127_1615712_2 1123401.JHYQ01000006_gene62 1.542e-123 400.0 COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria 1236|Gammaproteobacteria E transglutaminase-like - - - - - - - - - - - - Bact_transglu_N,Transglut_core CMS2_k127_1615712_1 1298593.TOL_1860 2.086e-139 447.0 COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,1RMXM@1236|Gammaproteobacteria,1XP16@135619|Oceanospirillales 135619|Oceanospirillales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core CMS2_k127_1624063_0 572480.Arnit_1757 1.504e-102 349.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,42Q4M@68525|delta/epsilon subdivisions,2YN67@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD,Prok-TraM CMS2_k127_1634118_21 457424.BFAG_02763 8.192e-06 54.0 COG0790@1|root,COG0790@2|Bacteria,4NMCC@976|Bacteroidetes,2FPRC@200643|Bacteroidia,4APK0@815|Bacteroidaceae 976|Bacteroidetes KLT COG0790 FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - Sel1 CMS2_k127_1634118_17 1165841.SULAR_05163 3.877e-42 157.0 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,42TRM@68525|delta/epsilon subdivisions,2YQ2J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1393 Arsenate reductase and related - - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC CMS2_k127_1634118_15 1537917.JU82_02430 1.883e-47 175.0 COG2203@1|root,COG2203@2|Bacteria,1NT6X@1224|Proteobacteria,42XRB@68525|delta/epsilon subdivisions,2YRTW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GAF domain - - - - - - - - - - - - GAF CMS2_k127_1634118_2 1158345.JNLL01000001_gene10 1.776e-204 647.0 arCOG03638@1|root,2Z8W3@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 CMS2_k127_1634118_19 1158345.JNLL01000001_gene9 9.14e-35 136.0 COG0347@1|root,COG0347@2|Bacteria 2|Bacteria K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II CMS2_k127_1634118_18 1123326.JFBL01000020_gene2664 7.206e-35 137.0 COG2905@1|root,COG2905@2|Bacteria,1RI05@1224|Proteobacteria,43BDH@68525|delta/epsilon subdivisions,2YPVH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS CMS2_k127_1634118_11 929558.SMGD1_1075 2.637e-59 209.0 COG2203@1|root,COG2203@2|Bacteria,1R0Y5@1224|Proteobacteria,42NT7@68525|delta/epsilon subdivisions,2YRW5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GAF domain - - - - - - - - - - - - GAF CMS2_k127_1634118_0 563040.Saut_0117 1.518e-237 748.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2YN3Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 CMS2_k127_1634118_12 765913.ThidrDRAFT_1372 1.233e-55 202.0 COG0500@1|root,COG2226@2|Bacteria,1NER3@1224|Proteobacteria,1S188@1236|Gammaproteobacteria,1WXVS@135613|Chromatiales 135613|Chromatiales Q PFAM methyltransferase - - - - - - - - - - - - Methyltransf_25 CMS2_k127_1634118_8 1249480.B649_11260 4.463e-80 276.0 COG0249@1|root,COG0249@2|Bacteria,1Q1X0@1224|Proteobacteria,42UKG@68525|delta/epsilon subdivisions,2YQ3M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KLT that it carries out the mismatch recognition step. This protein has a weak ATPase activity - - - - - - - - - - - - - CMS2_k127_1634118_14 572477.Alvin_2583 2.461e-53 199.0 COG2301@1|root,COG2301@2|Bacteria,1PX34@1224|Proteobacteria,1RR7R@1236|Gammaproteobacteria,1WW61@135613|Chromatiales 135613|Chromatiales G C-C_Bond_Lyase of the TIM-Barrel fold - - - - - - - - - - - - C-C_Bond_Lyase CMS2_k127_1634118_20 326298.Suden_0760 6.594e-25 110.0 COG1651@1|root,COG1651@2|Bacteria,1Q684@1224|Proteobacteria,432K4@68525|delta/epsilon subdivisions,2YSQB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - - - - - - - - - - - CMS2_k127_1634118_16 1537915.JU57_09290 6.889e-46 171.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,42SBG@68525|delta/epsilon subdivisions,2YP68@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM AMMECR1 domain protein - - - ko:K09141 - - - - ko00000 - - - AMMECR1 CMS2_k127_1634118_6 563040.Saut_1189 1.008e-102 344.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2YNC5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM CMS2_k127_1634118_5 929558.SMGD1_1650 4.871e-116 379.0 COG1578@1|root,COG1578@2|Bacteria,1RI11@1224|Proteobacteria,42RA1@68525|delta/epsilon subdivisions,2YNYT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function DUF89 - - - ko:K09116 - - - - ko00000 - - - DUF89 CMS2_k127_1634118_13 1537917.JU82_08640 1.29e-53 193.0 2AHPN@1|root,3181V@2|Bacteria,1PZNU@1224|Proteobacteria,42QWU@68525|delta/epsilon subdivisions,2YMYS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3972) - - - - - - - - - - - - DUF3972 CMS2_k127_1634118_7 709032.Sulku_2195 7.711e-83 279.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2YNW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC CMS2_k127_1634118_1 1172190.M947_07670 1.042e-223 699.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2YN6C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidase U32 family prtC - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 CMS2_k127_1634118_9 1249480.B649_10375 1.975e-78 268.0 2C2VD@1|root,338G0@2|Bacteria,1P3HX@1224|Proteobacteria,42NM6@68525|delta/epsilon subdivisions,2YM9Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1634118_4 929558.SMGD1_1645 3.19e-118 385.0 COG1387@1|root,COG1387@2|Bacteria,1RCEG@1224|Proteobacteria,42MIM@68525|delta/epsilon subdivisions,2YMFF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E histidinol phosphate phosphatase hisJ - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP,PHP_C CMS2_k127_1634118_10 1355368.JART01000001_gene683 1.991e-63 229.0 COG3016@1|root,COG3016@2|Bacteria 2|Bacteria S Haem-binding uptake, Tiki superfamily, ChaN phuW - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 CMS2_k127_1634118_3 563040.Saut_1878 8.177e-176 553.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2YNCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N CMS2_k127_1688104_0 929558.SMGD1_0721 7.875e-204 638.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2YN91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh CMS2_k127_1688104_1 667014.Thein_2135 1.309e-80 281.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - TraF_2 CMS2_k127_171000_0 387093.SUN_1760 2.248e-199 627.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2YMC8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh CMS2_k127_171000_2 5722.XP_001323756.1 1.022e-34 140.0 COG0666@1|root,KOG4177@2759|Eukaryota 5722.XP_001323756.1|- I spectrin binding - - - - - - - - - - - - - CMS2_k127_171000_1 1172190.M947_03510 1.825e-91 304.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2YMRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 CMS2_k127_1768110_17 1172190.M947_06490 4.906e-42 158.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2YMPF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 CMS2_k127_1768110_19 944546.ABED_1589 9.552e-42 156.0 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2YPYI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C CMS2_k127_1768110_2 1165841.SULAR_07595 2.552e-168 533.0 COG0492@1|root,COG0492@2|Bacteria,1NDW6@1224|Proteobacteria,42MUD@68525|delta/epsilon subdivisions,2YMV2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O pyridine nucleotide-disulfide oxidoreductase trxB_2 - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - FixS,Pyr_redox_3 CMS2_k127_1768110_15 1165841.SULAR_00515 1.955e-47 172.0 2C948@1|root,32SAI@2|Bacteria,1MZC2@1224|Proteobacteria,42U40@68525|delta/epsilon subdivisions,2YPYK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative mono-oxygenase ydhR - - - - - - - - - - - - ydhR CMS2_k127_1768110_7 929558.SMGD1_1260 4.387e-100 330.0 COG0789@1|root,COG0789@2|Bacteria,1NFNE@1224|Proteobacteria,42TCN@68525|delta/epsilon subdivisions,2YPGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K MerR HTH family regulatory protein - - - - - - - - - - - - MerR_1 CMS2_k127_1768110_11 929558.SMGD1_1465 7.063e-91 300.0 COG2391@1|root,COG2391@2|Bacteria,1Q38V@1224|Proteobacteria,43DQX@68525|delta/epsilon subdivisions,2YRGE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulphur transport - - - - - - - - - - - - Sulf_transp CMS2_k127_1768110_9 929558.SMGD1_1466 2.77e-94 312.0 COG2391@1|root,COG2391@2|Bacteria,1NENY@1224|Proteobacteria,42UYB@68525|delta/epsilon subdivisions,2YQYS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp CMS2_k127_1768110_12 929558.SMGD1_1261 5.592e-90 299.0 COG2128@1|root,COG2128@2|Bacteria,1PZ9M@1224|Proteobacteria,42PYF@68525|delta/epsilon subdivisions,2YNK8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD CMS2_k127_1768110_14 1165841.SULAR_00335 1.098e-55 198.0 COG0247@1|root,COG0247@2|Bacteria 2|Bacteria C lactate metabolic process - - - - - - - - - - - - DrsE CMS2_k127_1768110_8 709032.Sulku_0340 6.836e-100 331.0 COG0847@1|root,COG0847@2|Bacteria,1PDD1@1224|Proteobacteria,42MUX@68525|delta/epsilon subdivisions,2YNB6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0847 DNA polymerase III epsilon subunit and related 3'-5' - - 2.7.7.7 ko:K02342,ko:K10857 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T CMS2_k127_1768110_6 563040.Saut_0426 4.279e-119 396.0 COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,42NH5@68525|delta/epsilon subdivisions,2YMK5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member - - - - - - - - - - - - Herpes_Helicase,PIF1 CMS2_k127_1768110_1 387092.NIS_0032 1.138e-188 600.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42Q9B@68525|delta/epsilon subdivisions,2YNKN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - FCSD-flav_bind,Pyr_redox_2 CMS2_k127_1768110_10 1249480.B649_04295 7.788e-93 310.0 COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,42N9F@68525|delta/epsilon subdivisions,2YNBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske CMS2_k127_1768110_21 1249480.B649_04300 2.817e-19 92.0 2BQ12@1|root,319E3@2|Bacteria,1Q2GE@1224|Proteobacteria,42VNB@68525|delta/epsilon subdivisions,2YQEY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_1768110_4 1150621.SMUL_0515 5.147e-129 429.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2YP45@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M CMS2_k127_1768110_5 1537915.JU57_03765 2.827e-128 428.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2YMP5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M CMS2_k127_1768110_0 1355374.JARU01000001_gene406 1.122e-193 622.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2YN0B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N CMS2_k127_1768110_20 1150621.SMUL_0512 7.009e-22 98.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2YQEW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 CMS2_k127_1768110_18 760154.Sulba_0406 7.529e-42 159.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42UNF@68525|delta/epsilon subdivisions,2YQFG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 CMS2_k127_1768110_13 1442598.JABW01000005_gene559 7.336e-76 257.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42T2H@68525|delta/epsilon subdivisions,2YPIS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_7 CMS2_k127_1768110_3 1123326.JFBL01000011_gene177 1.166e-152 492.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2YMNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh CMS2_k127_1768110_16 1121403.AUCV01000026_gene2345 3.524e-44 171.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WKMJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C molybdopterin oxidoreductase Fe4S4 region nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3 CMS2_k127_2038598_10 326298.Suden_1494 4.376e-86 289.0 COG3381@1|root,COG3381@2|Bacteria,1N4MX@1224|Proteobacteria,42RVB@68525|delta/epsilon subdivisions,2YP5X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S component of anaerobic - - - - - - - - - - - - Nitrate_red_del CMS2_k127_2038598_9 709032.Sulku_0644 9.175e-133 432.0 COG1143@1|root,COG2768@1|root,COG1143@2|Bacteria,COG2768@2|Bacteria,1N7HT@1224|Proteobacteria 1224|Proteobacteria C 4fe-4s ferredoxin, iron-sulfur binding - - - - - - - - - - - - Fer4 CMS2_k127_2038598_18 326298.Suden_1492 4.847e-38 153.0 COG0169@1|root,COG0169@2|Bacteria,1Q1X7@1224|Proteobacteria,431CA@68525|delta/epsilon subdivisions,2YSA4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) - - - - - - - - - - - - Shikimate_dh_N CMS2_k127_2038598_15 1537917.JU82_09695 1.431e-54 196.0 2994D@1|root,2ZW7V@2|Bacteria,1Q2D1@1224|Proteobacteria,42VGB@68525|delta/epsilon subdivisions,2YQM6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2038598_11 1172190.M947_01115 1.511e-82 279.0 COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,42NNR@68525|delta/epsilon subdivisions,2YMH0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase CMS2_k127_2038598_13 1442598.JABW01000021_gene2067 1.007e-57 209.0 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2YNEW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 CMS2_k127_2038598_8 1537917.JU82_01960 3.439e-141 459.0 COG3347@1|root,COG3347@2|Bacteria,1QVWU@1224|Proteobacteria,43CKY@68525|delta/epsilon subdivisions,2YNA2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ PFAM Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II CMS2_k127_2038598_14 760154.Sulba_0600 1.389e-57 204.0 COG0748@1|root,COG0748@2|Bacteria,1MY8K@1224|Proteobacteria,42NQN@68525|delta/epsilon subdivisions,2YM8E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Heme iron utilization protein chuZ - - ko:K07226 - - - - ko00000 - - - DUF2470,Putative_PNPOx CMS2_k127_2038598_19 1121396.KB892946_gene2893 1.282e-36 158.0 2CDDI@1|root,32RXI@2|Bacteria,1N1M3@1224|Proteobacteria,42T3N@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_2038598_22 1307437.J139_08998 1.446e-05 58.0 COG2374@1|root,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RMHH@1236|Gammaproteobacteria,2Q0R9@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L extracellular nuclease - - - ko:K07004 - - - - ko00000 - - - Cadherin,Exo_endo_phos,LTD,PPC CMS2_k127_2038598_17 326298.Suden_1481 2.236e-47 171.0 COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,42UUW@68525|delta/epsilon subdivisions,2YQ5Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM CMS2_k127_2038598_4 326298.Suden_1477 1.29e-222 700.0 COG1070@1|root,COG1070@2|Bacteria,1MWS5@1224|Proteobacteria,43CSA@68525|delta/epsilon subdivisions,2YNV8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G COG1070 Sugar (pentulose and hexulose) - - 2.7.1.189 ko:K11216 ko02024,map02024 - R11183 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N CMS2_k127_2038598_21 1188252.AJYK01000071_gene2118 7.898e-07 56.0 COG0695@1|root,COG0695@2|Bacteria,1N12W@1224|Proteobacteria,1SCX6@1236|Gammaproteobacteria,1Y28V@135623|Vibrionales 135623|Vibrionales O Glutaredoxin - - - - - - - - - - - - Glutaredoxin CMS2_k127_2038598_16 1537917.JU82_09685 1.17e-51 189.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,42RMF@68525|delta/epsilon subdivisions,2YPMK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA CMS2_k127_2038598_6 1249480.B649_03240 1.235e-179 570.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2YME3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P sulfate adenylyltransferase sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 CMS2_k127_2038598_20 717231.Flexsi_0576 1.996e-08 65.0 COG2204@1|root,COG2204@2|Bacteria,2GF35@200930|Deferribacteres 200930|Deferribacteres T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_2038598_7 563040.Saut_1525 8.738e-145 467.0 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,42MJ6@68525|delta/epsilon subdivisions,2YMEK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) ispDF - 2.7.7.60,4.6.1.12 ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB CMS2_k127_2038598_2 563040.Saut_1524 1.476e-272 841.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2YMVM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM CMS2_k127_2038598_5 1537917.JU82_07765 6.485e-202 633.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2YMUN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA CMS2_k127_2038598_3 709032.Sulku_0659 2.058e-251 789.0 COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,42PZK@68525|delta/epsilon subdivisions,2YT9R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF CMS2_k127_2038598_0 563040.Saut_1521 1.387e-300 930.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2YMB1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iIT341.HP1532 GATase_6,SIS CMS2_k127_2038598_1 1249480.B649_03280 1.419e-299 941.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2YN0Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - DUF294,GlnD_UR_UTase,HD,NTP_transf_2 CMS2_k127_2038598_12 1249480.B649_03315 1.383e-75 255.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2YMA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM CMS2_k127_2053150_1 326298.Suden_1188 1.12e-33 137.0 COG1477@1|root,COG1477@2|Bacteria,1PFA4@1224|Proteobacteria,42S5P@68525|delta/epsilon subdivisions,2YPB3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE CMS2_k127_2053150_0 929558.SMGD1_0003 4.429e-40 164.0 2AJGC@1|root,31A2T@2|Bacteria,1Q4TA@1224|Proteobacteria,42ZUH@68525|delta/epsilon subdivisions,2YRV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2059458_3 1161401.ASJA01000008_gene1662 0.0009931 50.0 COG4834@1|root,COG4834@2|Bacteria,1MZ5H@1224|Proteobacteria,2U21M@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2184) - - - - - - - - - - - - DUF2184 CMS2_k127_2059458_0 1232410.KI421417_gene2772 1.217e-42 168.0 2CDSP@1|root,32RYD@2|Bacteria,1N213@1224|Proteobacteria,42U4H@68525|delta/epsilon subdivisions,2WQTU@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2059458_2 1437882.AZRU01000132_gene6661 0.0002712 53.0 COG3566@1|root,COG3566@2|Bacteria,1R7ZW@1224|Proteobacteria,1RU9Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09960 - - - - ko00000 - - - DUF2213 CMS2_k127_2059458_1 272626.lin1730 1.26e-13 80.0 COG2369@1|root,COG2369@2|Bacteria,1V5V6@1239|Firmicutes,4HIDN@91061|Bacilli 91061|Bacilli S Phage Mu protein F like protein - - - - - - - - - - - - ADPrib_exo_Tox,Phage_Mu_F CMS2_k127_20751_2 387093.SUN_1214 3.586e-191 602.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2YMT6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N CMS2_k127_20751_7 1249480.B649_09490 8.119e-47 171.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,42TGG@68525|delta/epsilon subdivisions,2YPWP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA CMS2_k127_20751_3 1165841.SULAR_02893 4.838e-148 474.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2YMY3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O hydrogenase expression formation protein hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C CMS2_k127_20751_1 1165841.SULAR_02898 1.996e-191 602.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2YMQU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the HypD family hypD - - ko:K04654 - - - - ko00000 - - - HypD CMS2_k127_20751_8 709032.Sulku_2035 2.847e-39 147.0 COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,42X24@68525|delta/epsilon subdivisions,2YPV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O hydrogenase assembly chaperone HypC hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC CMS2_k127_20751_4 749222.Nitsa_0085 4.052e-140 447.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2YMJ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KO Hydrogenase hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW CMS2_k127_20751_5 929558.SMGD1_2246 5.057e-75 257.0 COG2215@1|root,COG2215@2|Bacteria,1Q5AP@1224|Proteobacteria,42R81@68525|delta/epsilon subdivisions,2YP06@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the NiCoT transporter (TC 2.A.52) family - - - - - - - - - - - - - CMS2_k127_20751_0 1165841.SULAR_02918 3.972e-305 952.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2YM8M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF CMS2_k127_20751_6 1165841.SULAR_02928 3.574e-60 210.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2YP5U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C hydrogenase maturation protease hydD - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI CMS2_k127_2088174_6 929558.SMGD1_0635 2.193e-122 397.0 COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,42PCG@68525|delta/epsilon subdivisions,2YN6X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S metallophosphoesterase - - - ko:K09769 - - - - ko00000 - - - YmdB CMS2_k127_2088174_9 1537915.JU57_08555 1.768e-62 222.0 COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,42QYA@68525|delta/epsilon subdivisions,2YP2S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L endonuclease III magIII - - ko:K07457 - - - - ko00000 - - - HhH-GPD CMS2_k127_2088174_2 929558.SMGD1_0628 2.899e-214 681.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2YMWR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 CMS2_k127_2088174_7 709032.Sulku_0545 4.495e-116 379.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2YN3D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI GO:0003674,GO:0005488,GO:0005515,GO:0042802 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race CMS2_k127_2088174_1 1537917.JU82_03315 2.307e-231 722.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2YMCI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind CMS2_k127_2088174_5 572480.Arnit_0219 3.835e-135 441.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2YMKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI CMS2_k127_2088174_4 768670.Calni_0166 1.186e-143 462.0 COG1087@1|root,COG1087@2|Bacteria,2GF8N@200930|Deferribacteres 200930|Deferribacteres M Polysaccharide biosynthesis protein - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd CMS2_k127_2088174_3 709032.Sulku_2378 3.684e-214 670.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2YMJU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N CMS2_k127_2088174_0 709032.Sulku_2135 7.847e-253 783.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2YMID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N CMS2_k127_2088174_8 929558.SMGD1_1943 2.379e-83 280.0 COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,42QUT@68525|delta/epsilon subdivisions,2YNVS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 CMS2_k127_2094707_1 1165841.SULAR_01923 3.148e-68 236.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,42RUC@68525|delta/epsilon subdivisions,2YRIW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 CMS2_k127_2094707_0 1165841.SULAR_01918 9.948e-137 439.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,42N4S@68525|delta/epsilon subdivisions 1224|Proteobacteria S PFAM amine oxidase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 CMS2_k127_2131050_1 653733.Selin_0380 9.136e-48 177.0 COG3381@1|root,COG3381@2|Bacteria 2|Bacteria S protein complex oligomerization - - - - - - - - - - - - Nitrate_red_del CMS2_k127_2131050_0 398767.Glov_1148 7.475e-78 265.0 COG0437@1|root,COG0437@2|Bacteria,1RCHX@1224|Proteobacteria,42S80@68525|delta/epsilon subdivisions,2X5D4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin, iron-sulfur binding - - - - - - - - - - - - Fer4_11 CMS2_k127_2157660_3 1537917.JU82_02090 4.698e-36 143.0 COG5456@1|root,COG5456@2|Bacteria,1Q27X@1224|Proteobacteria,42V4G@68525|delta/epsilon subdivisions,2YQE8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P FixH - - - - - - - - - - - - FixH,YtkA CMS2_k127_2157660_2 1249480.B649_11105 6.841e-39 153.0 2AI9D@1|root,318Q0@2|Bacteria,1Q0R3@1224|Proteobacteria,42SDN@68525|delta/epsilon subdivisions,2YP0E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2157660_5 709032.Sulku_2346 4.629e-12 68.0 2AIVC@1|root,32MS0@2|Bacteria,1Q3D2@1224|Proteobacteria,42X4G@68525|delta/epsilon subdivisions,2YQTS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Family of unknown function (DUF4006) - - - - - - - - - - - - DUF4006 CMS2_k127_2157660_1 944547.ABLL_2574 3.712e-73 258.0 COG2010@1|root,COG2010@2|Bacteria,1PDTK@1224|Proteobacteria,42N5Z@68525|delta/epsilon subdivisions,2YMTR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N CMS2_k127_2157660_4 709032.Sulku_2348 1.869e-16 81.0 COG4736@1|root,COG4736@2|Bacteria,1QDIU@1224|Proteobacteria,42V2T@68525|delta/epsilon subdivisions,2YQ9S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O cytochrome c oxidase ccoQ - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ CMS2_k127_2157660_0 1537917.JU82_02120 2.637e-119 386.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,42NZG@68525|delta/epsilon subdivisions,2YMBE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cytochrome c oxidase, cbb3-type, subunit II ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - iIT341.HP0145 FixO CMS2_k127_2161543_2 563040.Saut_2044 4.344e-129 424.0 COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42Q6P@68525|delta/epsilon subdivisions 1224|Proteobacteria MU PFAM Outer membrane efflux protein cebC - - - - - - - - - - - OEP CMS2_k127_2161543_4 563040.Saut_2061 1.105e-41 156.0 2CCD9@1|root,2ZWK6@2|Bacteria,1P51X@1224|Proteobacteria,42V7G@68525|delta/epsilon subdivisions,2YQ8K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S YtkA-like - - - - - - - - - - - - YtkA CMS2_k127_2161543_3 272134.KB731325_gene655 3.214e-63 221.0 COG2110@1|root,COG2110@2|Bacteria,1G5VN@1117|Cyanobacteria,1HB5V@1150|Oscillatoriales 1117|Cyanobacteria S C-terminal domain of histone - - - - - - - - - - - - Macro CMS2_k127_2161543_5 1205908.AKXW01000033_gene1401 1.845e-30 126.0 2EVSB@1|root,33P68@2|Bacteria,1P3SK@1224|Proteobacteria,1SS80@1236|Gammaproteobacteria,1XYJ3@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF1353) - - - - - - - - - - - - DUF1353 CMS2_k127_2161543_0 317025.Tcr_2108 9.071e-219 685.0 COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria,1T9HN@1236|Gammaproteobacteria,461QT@72273|Thiotrichales 72273|Thiotrichales E PFAM Amino acid - - - - - - - - - - - - AA_permease_2 CMS2_k127_2161543_1 929558.SMGD1_1620 1.603e-162 515.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2YMMK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 CMS2_k127_2168803_5 929558.SMGD1_0933 2.486e-43 159.0 COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,42V85@68525|delta/epsilon subdivisions,2YPSA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Nitrogen fixation protein NifU - - - - - - - - - - - - NifU CMS2_k127_2168803_4 563040.Saut_0296 4.114e-63 224.0 2AJZN@1|root,31ANZ@2|Bacteria,1Q5WH@1224|Proteobacteria,42UJ4@68525|delta/epsilon subdivisions,2YPXB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2168803_0 563040.Saut_0297 1.01e-201 635.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2YN43@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M CMS2_k127_2168803_2 563040.Saut_0116 2.231e-162 522.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,42MZ6@68525|delta/epsilon subdivisions,2YN30@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF CMS2_k127_2168803_1 1165841.SULAR_02883 3.367e-201 634.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2YNFF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P transporter - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp CMS2_k127_2168803_3 929558.SMGD1_1698 1.364e-88 299.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2YMKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT CMS2_k127_2178425_2 1172190.M947_09145 1.906e-45 168.0 COG0711@1|root,COG0711@2|Bacteria,1Q2G9@1224|Proteobacteria,42VN4@68525|delta/epsilon subdivisions,2YQBE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the ATPase B chain family atpF' - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B CMS2_k127_2178425_1 1537917.JU82_04610 3.7e-87 296.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2YNN2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc CMS2_k127_2178425_0 1537917.JU82_04605 1.03e-138 443.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2YMZQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 CMS2_k127_2185638_1 563040.Saut_0316 9.992e-77 259.0 COG0244@1|root,COG0244@2|Bacteria,1RB0Y@1224|Proteobacteria,43B5K@68525|delta/epsilon subdivisions,2YPHB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 CMS2_k127_2185638_0 563040.Saut_0315 2.642e-118 383.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2YMN7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 CMS2_k127_2185638_2 1172190.M947_07060 3.225e-32 126.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2YNWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N CMS2_k127_2200141_41 326298.Suden_0269 2.253e-56 208.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42M22@68525|delta/epsilon subdivisions,2YM8Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,Cache_3-Cache_2,MCPsignal,dCache_1 CMS2_k127_2200141_26 709032.Sulku_0706 3.152e-116 387.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,42UPM@68525|delta/epsilon subdivisions,2YRIE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T EAL domain - - - - - - - - - - - - EAL CMS2_k127_2200141_2 572480.Arnit_1048 8.072e-278 881.0 COG0835@1|root,COG0835@2|Bacteria,1QVCF@1224|Proteobacteria,42M0F@68525|delta/epsilon subdivisions,2YNAP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT PFAM CheW domain protein - - - - - - - - - - - - CheW,dCache_1 CMS2_k127_2200141_45 709032.Sulku_1353 1.513e-42 158.0 COG0818@1|root,COG0818@2|Bacteria,1Q5TS@1224|Proteobacteria,42SZA@68525|delta/epsilon subdivisions,2YSYV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Recycling of diacylglycerol produced during the turnover of membrane phospholipid - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar CMS2_k127_2200141_4 1537917.JU82_01230 3.526e-226 704.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,42MHS@68525|delta/epsilon subdivisions,2YM99@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Saccharopine dehydrogenase LYS1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP CMS2_k127_2200141_39 177439.DP0001 8.253e-64 225.0 COG2227@1|root,COG2227@2|Bacteria,1R9ZR@1224|Proteobacteria,42TXJ@68525|delta/epsilon subdivisions,2WPAR@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 CMS2_k127_2200141_8 1249480.B649_05720 1.042e-204 641.0 COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,42MVP@68525|delta/epsilon subdivisions,2YMY4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_DAP_Arg_deC CMS2_k127_2200141_36 1249480.B649_00035 8.072e-81 289.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N6Y@68525|delta/epsilon subdivisions 1224|Proteobacteria T ATP-binding region ATPase domain protein - - - - - - - - - - - - CHASE5,GAF,HATPase_c,HisKA,PAS_4,Response_reg,dCache_2,sCache_2 CMS2_k127_2200141_22 1249480.B649_00045 3.123e-132 441.0 COG0784@1|root,COG5001@1|root,COG0784@2|Bacteria,COG5001@2|Bacteria,1MUNI@1224|Proteobacteria 1224|Proteobacteria T COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - - - - - - - - - - DUF3369,EAL,GGDEF,Response_reg CMS2_k127_2200141_25 929558.SMGD1_0079 8.132e-122 398.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2YM8Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA CMS2_k127_2200141_29 367737.Abu_0650 5.183e-103 342.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2YMSS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ CMS2_k127_2200141_6 929558.SMGD1_0025 5.392e-208 650.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2YMJB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT CMS2_k127_2200141_12 563040.Saut_1268 3.968e-185 590.0 COG3400@1|root,COG3400@2|Bacteria,1N5T1@1224|Proteobacteria,42M0B@68525|delta/epsilon subdivisions,2YMCG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S domain protein - - - ko:K09944 - - - - ko00000 - - - TrkA_C CMS2_k127_2200141_18 563040.Saut_1267 3.202e-150 482.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2YN4M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0283 DHQ_synthase CMS2_k127_2200141_14 1172190.M947_01570 1.027e-182 587.0 COG0668@1|root,COG0668@2|Bacteria,1PMY3@1224|Proteobacteria,42M4K@68525|delta/epsilon subdivisions,2YMAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M mechanosensitive ion channel - - - - - - - - - - - - MS_channel CMS2_k127_2200141_11 709032.Sulku_1012 1.721e-186 590.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2YN0D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J MiaB-like tRNA modifying enzyme yqeV - - - - - - - - - - - Radical_SAM,UPF0004 CMS2_k127_2200141_16 709032.Sulku_1013 6.39e-159 517.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42NK1@68525|delta/epsilon subdivisions,2YMHN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the AAA ATPase family ftsH1 - - - - - - - - - - - AAA,Peptidase_M41 CMS2_k127_2200141_31 1249480.B649_07305 3.839e-102 333.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42PGH@68525|delta/epsilon subdivisions,2YN8W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Molybdenum cofactor biosynthesis protein mogA - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth CMS2_k127_2200141_23 563040.Saut_1259 5.577e-127 409.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2YNB3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L exodeoxyribonuclease III xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos CMS2_k127_2200141_32 572480.Arnit_2666 9.177e-98 327.0 COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,42NAY@68525|delta/epsilon subdivisions,2YMAV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase frdC - - ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt CMS2_k127_2200141_0 929558.SMGD1_0558 0.0 1062.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit frdA - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS2_k127_2200141_27 929558.SMGD1_0557 6.16e-116 378.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2YMFW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family frdB - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 CMS2_k127_2200141_48 572480.Arnit_0864 1.402e-30 126.0 297UU@1|root,2ZV1D@2|Bacteria,1MXFE@1224|Proteobacteria,430YU@68525|delta/epsilon subdivisions,2YS1X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2200141_13 367737.Abu_0298 2.193e-184 602.0 COG0699@1|root,COG0699@2|Bacteria,1NAXY@1224|Proteobacteria,42NA8@68525|delta/epsilon subdivisions,2YN7Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N CMS2_k127_2200141_7 572480.Arnit_2670 1.967e-207 665.0 COG0699@1|root,COG0699@2|Bacteria,1NBKR@1224|Proteobacteria,42NDN@68525|delta/epsilon subdivisions,2YN3H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GTP-binding protein - - - - - - - - - - - - Dynamin_N CMS2_k127_2200141_42 944547.ABLL_2325 1.031e-50 195.0 COG0479@1|root,COG2048@1|root,COG0479@2|Bacteria,COG2048@2|Bacteria,1QE4T@1224|Proteobacteria,42QE6@68525|delta/epsilon subdivisions,2YM7P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit - - - - - - - - - - - - - CMS2_k127_2200141_52 1415775.U729_3036 1.199e-19 98.0 arCOG07807@1|root,32S82@2|Bacteria,1VE45@1239|Firmicutes,24BWC@186801|Clostridia,36NIJ@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - DUF2971 CMS2_k127_2200141_17 563040.Saut_1258 6.347e-155 492.0 COG2048@1|root,COG2048@2|Bacteria,1RFWK@1224|Proteobacteria,43B86@68525|delta/epsilon subdivisions,2YT6P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Heterodisulfide reductase subunit B - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - CCG CMS2_k127_2200141_19 929558.SMGD1_2780 1.088e-147 473.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2YN8F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family frdB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0191 Fer2_3,Fer4_8 CMS2_k127_2200141_1 709032.Sulku_1574 0.0 1007.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS2_k127_2200141_35 929558.SMGD1_2778 2.088e-81 285.0 COG2199@1|root,COG3706@2|Bacteria,1Q5A3@1224|Proteobacteria,430W0@68525|delta/epsilon subdivisions,2YRZB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF CMS2_k127_2200141_33 929558.SMGD1_2777 1.79e-90 305.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2YN0I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS CMS2_k127_2200141_21 1537917.JU82_06135 7.181e-139 450.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2YNAC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD CMS2_k127_2200141_30 326298.Suden_1033 9.312e-103 341.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,42PAW@68525|delta/epsilon subdivisions,2YNM3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase CMS2_k127_2200141_9 709032.Sulku_1569 1.702e-194 610.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2YMDC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C CMS2_k127_2200141_47 273121.WS1867 1.995e-38 152.0 COG1434@1|root,COG1434@2|Bacteria,1Q9D9@1224|Proteobacteria,43122@68525|delta/epsilon subdivisions,2YS8G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DUF218 domain - - - - - - - - - - - - DUF218 CMS2_k127_2200141_15 1537917.JU82_00090 3.629e-173 556.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2YMS0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N CMS2_k127_2200141_3 929558.SMGD1_2756 2.018e-239 743.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2YMH1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_2200141_37 1249480.B649_07235 5.915e-77 261.0 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,42QSH@68525|delta/epsilon subdivisions,2YNVB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran CMS2_k127_2200141_44 326298.Suden_1117 8.192e-45 164.0 2AV85@1|root,31KYU@2|Bacteria,1QITS@1224|Proteobacteria,42SB2@68525|delta/epsilon subdivisions,2YQ0M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2200141_38 709032.Sulku_1563 1.418e-73 250.0 COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,42SAN@68525|delta/epsilon subdivisions,2YPGI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB CMS2_k127_2200141_34 1249480.B649_07220 9.454e-82 277.0 COG1994@1|root,COG1994@2|Bacteria,1N531@1224|Proteobacteria,43AZN@68525|delta/epsilon subdivisions,2YP0U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 CMS2_k127_2200141_24 326298.Suden_1114 5.996e-124 402.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2YM8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 CMS2_k127_2200141_20 563040.Saut_1226 1.493e-142 456.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2YM9U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C CMS2_k127_2200141_50 679897.HMU06440 3.558e-28 116.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c cccE - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 CMS2_k127_2200141_28 1249480.B649_07200 5.843e-106 351.0 COG2301@1|root,COG2301@2|Bacteria,1NUDQ@1224|Proteobacteria,42QUW@68525|delta/epsilon subdivisions,2YNZV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the HpcH HpaI aldolase family citE - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI CMS2_k127_2200141_53 1122603.ATVI01000008_gene2394 6.732e-16 85.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,1X6BK@135614|Xanthomonadales 135614|Xanthomonadales S paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA CMS2_k127_2200141_43 1097668.BYI23_A003530 1.693e-45 171.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2VMXT@28216|Betaproteobacteria,1K33I@119060|Burkholderiaceae 28216|Betaproteobacteria S paraquat-inducible protein A pqiA - - ko:K03808 - - - - ko00000 - - - PqiA CMS2_k127_2200141_10 313628.LNTAR_15492 2.094e-191 629.0 COG3008@1|root,COG3008@2|Bacteria 2|Bacteria Q intermembrane lipid transfer yebT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0016020,GO:0016021,GO:0016043,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0071944,GO:0120009 - ko:K06192 - - - - ko00000 - - - MlaD CMS2_k127_2200141_40 929558.SMGD1_2737 5.861e-58 213.0 COG0810@1|root,COG0810@2|Bacteria,1PEYQ@1224|Proteobacteria,42WJI@68525|delta/epsilon subdivisions,2YQ9A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_2,TonB_C CMS2_k127_2200141_5 929558.SMGD1_2736 5.91e-221 691.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2YM9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS2_k127_2200141_49 1249480.B649_05685 1.143e-29 120.0 COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42VGZ@68525|delta/epsilon subdivisions,2YQ8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 CMS2_k127_2200141_51 1355374.JARU01000004_gene1623 3.846e-25 111.0 2AIU4@1|root,319B6@2|Bacteria,1Q28N@1224|Proteobacteria,42V6E@68525|delta/epsilon subdivisions,2YQ6D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2205114_2 326298.Suden_0447 1.894e-97 324.0 COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42N4V@68525|delta/epsilon subdivisions,2YN04@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RluA family rluA - 5.4.99.23,5.4.99.24 ko:K06179,ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 CMS2_k127_2205114_0 563040.Saut_1760 1.324e-211 665.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2YMQM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB CMS2_k127_2205114_5 525898.Sdel_0390 1.14e-49 184.0 COG0664@1|root,COG0664@2|Bacteria,1PT5K@1224|Proteobacteria,42STJ@68525|delta/epsilon subdivisions,2YPG1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K cyclic nucleotide-binding - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding CMS2_k127_2205114_3 760154.Sulba_0437 5.515e-54 194.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2YPJX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS2_k127_2205114_6 1249480.B649_02490 1.362e-35 136.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,42V30@68525|delta/epsilon subdivisions,2YPWV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 CMS2_k127_2205114_7 929558.SMGD1_0770 2.113e-31 124.0 COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42VEW@68525|delta/epsilon subdivisions,2YQ7J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S RNA-binding protein - - - ko:K06960 - - - - ko00000 - - - KH_4 CMS2_k127_2205114_4 709032.Sulku_0498 1.357e-51 188.0 COG0806@1|root,COG0806@2|Bacteria,1MYUH@1224|Proteobacteria,42SEN@68525|delta/epsilon subdivisions,2YPH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM CMS2_k127_2205114_1 929558.SMGD1_0768 4.555e-99 327.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2YM7K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT CMS2_k127_2208773_1 929558.SMGD1_1470 1.484e-50 183.0 COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,42P4D@68525|delta/epsilon subdivisions,2YMZD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA selU - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese CMS2_k127_2208773_0 1172190.M947_05855 0.0 1057.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2YMDG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD CMS2_k127_2208773_2 326298.Suden_0067 8.111e-08 53.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2YNX4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N CMS2_k127_2218652_6 563040.Saut_1323 6.024e-18 89.0 2AJ4J@1|root,319P3@2|Bacteria,1Q3DP@1224|Proteobacteria,42X5G@68525|delta/epsilon subdivisions,2YQYN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2218652_3 563040.Saut_1038 6.08e-33 137.0 COG3076@1|root,COG3076@2|Bacteria,1N195@1224|Proteobacteria,430TX@68525|delta/epsilon subdivisions,2YS1B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Family of unknown function (DUF695) - - - - - - - - - - - - DUF695,RraB CMS2_k127_2218652_2 929558.SMGD1_0958 1.008e-40 154.0 COG5485@1|root,COG5485@2|Bacteria,1N1VS@1224|Proteobacteria,42WUC@68525|delta/epsilon subdivisions,2YS7Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ester cyclase - - - - - - - - - - - - SnoaL CMS2_k127_2218652_1 387093.SUN_1165 5.918e-49 183.0 COG0789@1|root,COG0789@2|Bacteria,1NFNE@1224|Proteobacteria,42TCN@68525|delta/epsilon subdivisions,2YPGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K MerR HTH family regulatory protein - - - - - - - - - - - - MerR_1 CMS2_k127_2218652_0 207954.MED92_14433 0.0 1302.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1XIGR@135619|Oceanospirillales 135619|Oceanospirillales I Acyltransferase - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 CMS2_k127_2233633_0 653733.Selin_0857 2.556e-312 980.0 COG0841@1|root,COG0841@2|Bacteria 2|Bacteria V transmembrane transporter activity acrD - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran CMS2_k127_2233633_1 944547.ABLL_0731 7.354e-64 231.0 COG0845@1|root,COG0845@2|Bacteria,1RI9S@1224|Proteobacteria,42T1D@68525|delta/epsilon subdivisions,2YPK5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 CMS2_k127_2233633_3 1123326.JFBL01000007_gene635 1.036e-24 109.0 COG1846@1|root,COG1846@2|Bacteria,1NHZH@1224|Proteobacteria,42Y4P@68525|delta/epsilon subdivisions,2YQU6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 CMS2_k127_2233633_2 572480.Arnit_0024 3.722e-43 168.0 COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,42VIX@68525|delta/epsilon subdivisions,2YQBR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Bacterial regulatory helix-turn-helix protein, lysR family modE - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1 CMS2_k127_2234748_35 1249480.B649_07780 0.0003061 43.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2YMEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin CMS2_k127_2234748_4 1537917.JU82_11285 2.993e-221 693.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2YM8S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA CMS2_k127_2234748_9 709032.Sulku_0862 1.092e-121 407.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2YMFX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N_3 CMS2_k127_2234748_13 929558.SMGD1_2354 9.657e-69 238.0 COG0235@1|root,COG0235@2|Bacteria,1N84G@1224|Proteobacteria,42RVW@68525|delta/epsilon subdivisions,2YP4S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II CMS2_k127_2234748_8 563040.Saut_0845 1.577e-132 428.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2YMRK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 CMS2_k127_2234748_1 326298.Suden_0799 0.0 1217.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2YMMN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran CMS2_k127_2234748_32 1499967.BAYZ01000091_gene3428 3.704e-25 119.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - OprB,PorP_SprF,SLH,Toluene_X CMS2_k127_2234748_2 525897.Dbac_0986 0.0 1170.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2MEHZ@213115|Desulfovibrionales 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS CMS2_k127_2234748_31 1121035.AUCH01000006_gene668 1.515e-25 113.0 2AIHJ@1|root,318ZE@2|Bacteria,1Q18Q@1224|Proteobacteria,2W6AT@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2234748_15 1165841.SULAR_06623 1.004e-65 228.0 COG2703@1|root,COG2703@2|Bacteria 2|Bacteria P oxygen carrier activity - - - ko:K07216 - - - - ko00000 - - - Hemerythrin CMS2_k127_2234748_16 1165841.SULAR_02023 2.776e-62 215.0 COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,42TC4@68525|delta/epsilon subdivisions,2YPRJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin CMS2_k127_2234748_22 709032.Sulku_1798 1.133e-46 174.0 29X80@1|root,30IX9@2|Bacteria,1PTJK@1224|Proteobacteria,43DQB@68525|delta/epsilon subdivisions,2YSA6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Cytochrome P460 - - - - - - - - - - - - Cytochrome_P460 CMS2_k127_2234748_11 326298.Suden_1027 1.294e-83 279.0 COG3193@1|root,COG3193@2|Bacteria,1RJ3X@1224|Proteobacteria 1224|Proteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading CMS2_k127_2234748_14 1167006.UWK_00966 1.909e-67 233.0 28M05@1|root,32SJ0@2|Bacteria,1N115@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_2234748_20 1165841.SULAR_01050 5.149e-48 174.0 COG2346@1|root,COG2346@2|Bacteria 2|Bacteria O COG2346, Truncated hemoglobins - - - ko:K06886 - - - - ko00000 - - - Bac_globin CMS2_k127_2234748_23 1165841.SULAR_01045 1.716e-41 155.0 COG2127@1|root,COG2127@2|Bacteria 2|Bacteria T Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 - ko:K06891 - - - - ko00000 - - - ClpS CMS2_k127_2234748_12 1165841.SULAR_01040 1.585e-70 239.0 COG2703@1|root,COG2703@2|Bacteria 2|Bacteria P oxygen carrier activity - - - ko:K07216 - - - - ko00000 - - - Hemerythrin CMS2_k127_2234748_0 1165841.SULAR_01035 0.0 1609.0 COG0465@1|root,COG0465@2|Bacteria,1NQVB@1224|Proteobacteria,42MWB@68525|delta/epsilon subdivisions,2YR9A@29547|Epsilonproteobacteria 2|Bacteria O Peptidase family M41 - - - - - - - - - - - - AAA,Peptidase_M41 CMS2_k127_2234748_18 1165841.SULAR_06628 1.088e-58 205.0 COG2703@1|root,COG2703@2|Bacteria 2|Bacteria P oxygen carrier activity - - - ko:K07216 - - - - ko00000 - - - Hemerythrin CMS2_k127_2234748_6 387093.SUN_0660 1.262e-155 494.0 COG3431@1|root,COG3431@2|Bacteria,1MYY4@1224|Proteobacteria,42RU3@68525|delta/epsilon subdivisions,2YNHN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protoglobin - - - - - - - - - - - - Protoglobin,PsiE CMS2_k127_2234748_26 1499967.BAYZ01000097_gene4355 1.005e-35 143.0 COG2426@1|root,COG2426@2|Bacteria 2|Bacteria S small multidrug export protein - - - - - - - - - - - - Sm_multidrug_ex CMS2_k127_2234748_17 929558.SMGD1_1005 6.789e-59 207.0 COG2731@1|root,COG2731@2|Bacteria,1N8IZ@1224|Proteobacteria,42W19@68525|delta/epsilon subdivisions,2YSZX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Domain of unknown function (DUF386) - - - - - - - - - - - - DUF386 CMS2_k127_2234748_3 869213.JCM21142_104080 0.0 1081.0 COG2352@1|root,COG2352@2|Bacteria,4NFC0@976|Bacteroidetes,47NF0@768503|Cytophagia 976|Bacteroidetes C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase CMS2_k127_2234748_19 1165841.SULAR_00805 3.767e-56 198.0 COG3651@1|root,COG3651@2|Bacteria,1RH68@1224|Proteobacteria,42TUY@68525|delta/epsilon subdivisions 1224|Proteobacteria S Uncharacterized protein conserved in bacteria (DUF2237) - - - ko:K09966 - - - - ko00000 - - - DUF2237 CMS2_k127_2234748_5 929558.SMGD1_2511 2.761e-182 575.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,42NEF@68525|delta/epsilon subdivisions,2YTM5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN CMS2_k127_2234748_27 237368.SCABRO_03302 1.836e-34 137.0 COG2033@1|root,COG2033@2|Bacteria 2|Bacteria C superoxide reductase activity sorA - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrodox CMS2_k127_2234748_28 218284.CCDN010000001_gene893 1.175e-32 135.0 28VWJ@1|root,2ZHXX@2|Bacteria,1W3TF@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - CMS2_k127_2234748_34 1172190.M947_09350 1.579e-14 78.0 2BT5R@1|root,32NAM@2|Bacteria,1Q3P8@1224|Proteobacteria,42XKB@68525|delta/epsilon subdivisions,2YQR6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2234748_10 929558.SMGD1_0155 4.767e-102 340.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2YMCC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt CMS2_k127_2234748_7 326298.Suden_0859 3.813e-143 466.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2YMMM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH CMS2_k127_2234748_21 709032.Sulku_0870 8.432e-48 172.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2YMKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit CMS2_k127_2236589_1 1165841.SULAR_01878 1.005e-69 237.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2YMH1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_2236589_0 944547.ABLL_2639 9.479e-171 548.0 COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2YM7Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867,NAD_binding_10 CMS2_k127_2248579_5 929558.SMGD1_0535 9.192e-21 91.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2YMA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM CMS2_k127_2248579_0 1165841.SULAR_03128 1.609e-197 620.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42N1P@68525|delta/epsilon subdivisions,2YP3M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E COG0436 Aspartate tyrosine aromatic aminotransferase - - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_2248579_4 563040.Saut_1514 5.032e-72 252.0 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2YP9I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 CMS2_k127_2248579_1 1123517.JOMR01000001_gene1614 1.785e-137 445.0 COG2199@1|root,COG2199@2|Bacteria,1NYG9@1224|Proteobacteria,1RV5M@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,Protoglobin CMS2_k127_2248579_2 1249480.B649_03320 2.603e-91 303.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2YTQW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH Anthranilate synthase trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase CMS2_k127_2248579_3 1123326.JFBL01000004_gene2219 4.423e-90 310.0 COG1807@1|root,COG1807@2|Bacteria,1Q901@1224|Proteobacteria,42MGX@68525|delta/epsilon subdivisions,2YNER@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M integral membrane protein - - - - - - - - - - - - PMT_2 CMS2_k127_2248579_6 1537917.JU82_00855 2.267e-18 84.0 COG0045@1|root,COG0045@2|Bacteria,1PYM0@1224|Proteobacteria,42NR1@68525|delta/epsilon subdivisions,2YMG6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the succinate malate CoA ligase beta subunit family - - 2.3.3.8 ko:K15231 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Citrate_bind CMS2_k127_2252876_1 1165841.SULAR_01918 7.348e-50 178.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,42N4S@68525|delta/epsilon subdivisions 1224|Proteobacteria S PFAM amine oxidase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 CMS2_k127_2252876_0 1165841.SULAR_01923 5.033e-102 338.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,42RUC@68525|delta/epsilon subdivisions,2YRIW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 CMS2_k127_2252876_2 1165841.SULAR_01928 4.921e-34 136.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2YNRG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG2230 Cyclopropane fatty acid synthase and related cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS CMS2_k127_2279594_0 563040.Saut_0553 1.21e-286 885.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2YN1U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP CMS2_k127_2279594_3 1249480.B649_10480 1.59e-75 258.0 COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,42RIW@68525|delta/epsilon subdivisions,2YP6Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane-associated protein dedA - - - - - - - - - - - SNARE_assoc CMS2_k127_2279594_4 1249480.B649_02450 3.256e-37 147.0 COG0457@1|root,COG0457@2|Bacteria,1NRB9@1224|Proteobacteria,42W0K@68525|delta/epsilon subdivisions,2YQ9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11,TPR_2,TPR_8 CMS2_k127_2279594_2 1249480.B649_02455 1.165e-95 319.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,42QHV@68525|delta/epsilon subdivisions,2YNYV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S NYN domain - - - - - - - - - - - - NYN,OST-HTH CMS2_k127_2279594_1 326298.Suden_0444 3.373e-114 372.0 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,42MHJ@68525|delta/epsilon subdivisions,2YMM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S dinuclear metal center protein, YbgI - - 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - NIF3 CMS2_k127_2279594_5 1172190.M947_06755 1.376e-11 66.0 COG1579@1|root,COG1579@2|Bacteria,1R7GT@1224|Proteobacteria,42P3S@68525|delta/epsilon subdivisions,2YMAN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG1579 Zn-ribbon protein possibly nucleic acid-binding - - 3.5.4.16 ko:K07164,ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - zf-RING_7 CMS2_k127_2295171_0 709032.Sulku_2278 5.189e-84 279.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2YMZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 CMS2_k127_2295171_6 1121121.KB894295_gene4395 5.206e-06 49.0 2DH1M@1|root,2ZY2Y@2|Bacteria,1W68J@1239|Firmicutes,4I0XP@91061|Bacilli,273X4@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - CMS2_k127_2295171_1 929558.SMGD1_0903 1.193e-79 273.0 COG1234@1|root,COG2203@1|root,COG3437@1|root,COG1234@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,1RGKE@1224|Proteobacteria,42QI9@68525|delta/epsilon subdivisions,2YTB9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T cAMP phosphodiesterases class-II - - - - - - - - - - - - GAF,HD,PDEase_II CMS2_k127_2295171_2 709032.Sulku_2279 1.226e-69 244.0 COG3022@1|root,COG3022@2|Bacteria,1Q5IV@1224|Proteobacteria,42QYB@68525|delta/epsilon subdivisions,2YNY3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0246 family - - - ko:K09861 - - - - ko00000 - - - H2O2_YaaD CMS2_k127_2295171_3 929558.SMGD1_0838 8.333e-38 144.0 COG1544@1|root,COG1544@2|Bacteria,1QNAY@1224|Proteobacteria,430WG@68525|delta/epsilon subdivisions,2YS0N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Sigma 54 modulation protein / S30EA ribosomal protein - - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE CMS2_k127_2295171_4 326298.Suden_0342 5.094e-30 122.0 COG0526@1|root,COG0526@2|Bacteria,1QZ1W@1224|Proteobacteria,43CE3@68525|delta/epsilon subdivisions,2YTBP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thioredoxin - - - - - - - - - - - - Thioredoxin CMS2_k127_2295171_5 929558.SMGD1_0148 5.343e-13 73.0 28QM5@1|root,319KE@2|Bacteria,1Q3DZ@1224|Proteobacteria,42X5X@68525|delta/epsilon subdivisions,2YQT9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2347891_90 1172190.M947_06870 1.691e-06 51.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42Z31@68525|delta/epsilon subdivisions,2YRAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Hpt sensor hybrid histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg CMS2_k127_2347891_34 563040.Saut_1539 2.873e-110 361.0 COG0745@1|root,COG0745@2|Bacteria,1PGAE@1224|Proteobacteria,4348Y@68525|delta/epsilon subdivisions,2YREY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_2347891_22 1249480.B649_02835 9.938e-140 456.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42M1K@68525|delta/epsilon subdivisions,2YMKR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the peptidase M24B family pepQ - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C CMS2_k127_2347891_51 929558.SMGD1_0567 6.556e-83 281.0 COG2733@1|root,COG2733@2|Bacteria,1R4JT@1224|Proteobacteria,42RK1@68525|delta/epsilon subdivisions,2YPBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - CMS2_k127_2347891_59 1499686.BN1079_01630 1.037e-63 221.0 28NR0@1|root,2ZBQD@2|Bacteria,1RA2I@1224|Proteobacteria,1S270@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Nucleoside 2-deoxyribosyltransferase YtoQ - - - - - - - - - - - - Nuc_deoxyri_tr3 CMS2_k127_2347891_82 1537917.JU82_05220 1.129e-20 93.0 COG2501@1|root,COG2501@2|Bacteria,1PFA5@1224|Proteobacteria,42XJ3@68525|delta/epsilon subdivisions,2YS84@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S S4 domain - - - ko:K14761 - - - - ko00000,ko03009 - - - S4_2 CMS2_k127_2347891_57 1165841.SULAR_05893 8.533e-70 241.0 COG3038@1|root,COG3038@2|Bacteria,1NC3G@1224|Proteobacteria,42SCY@68525|delta/epsilon subdivisions,2YQ0N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB CMS2_k127_2347891_71 709032.Sulku_0393 9.098e-37 141.0 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2YQAF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S RNA-binding protein rbpA - - - - - - - - - - - RRM_1 CMS2_k127_2347891_4 709032.Sulku_1277 2.093e-241 764.0 COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,42MPY@68525|delta/epsilon subdivisions,2YMV7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C phosphate acetyltransferase pta - 2.3.1.8 ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,DRTGG,PTA_PTB CMS2_k127_2347891_24 1167006.UWK_00319 4.638e-132 431.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,42MJA@68525|delta/epsilon subdivisions,2WJBJ@28221|Deltaproteobacteria,2MIMM@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase CMS2_k127_2347891_72 563040.Saut_0642 3.925e-36 142.0 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,42RE5@68525|delta/epsilon subdivisions,2YSYY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S SEC-C motif - - - ko:K09858 - - - - ko00000 - - - SEC-C CMS2_k127_2347891_32 598659.NAMH_0374 7.438e-116 399.0 COG0497@1|root,COG2319@1|root,COG0497@2|Bacteria,COG2319@2|Bacteria,1Q4XR@1224|Proteobacteria,42PRP@68525|delta/epsilon subdivisions,2YMZB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L WD40 repeats - - - - - - - - - - - - WD40 CMS2_k127_2347891_2 1537917.JU82_05240 1.126e-283 877.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2YMB5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S abc transporter atp-binding protein yheS - - - - - - - - - - - ABC_tran,ABC_tran_Xtn CMS2_k127_2347891_36 1537917.JU82_05245 5.569e-106 350.0 2DBB6@1|root,2Z85M@2|Bacteria,1QMDX@1224|Proteobacteria,42QTF@68525|delta/epsilon subdivisions,2YP1H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2347891_1 929558.SMGD1_2116 2.924e-288 902.0 COG1196@1|root,COG1196@2|Bacteria,1QEEI@1224|Proteobacteria,43DPF@68525|delta/epsilon subdivisions,2YRNC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - CMS2_k127_2347891_79 1519439.JPJG01000087_gene702 8.075e-25 106.0 COG4728@1|root,COG4728@2|Bacteria,1VENJ@1239|Firmicutes,24SFD@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - DUF1653 CMS2_k127_2347891_78 929558.SMGD1_0585 2.064e-25 109.0 COG0023@1|root,COG0023@2|Bacteria,1Q2ID@1224|Proteobacteria,42VSB@68525|delta/epsilon subdivisions,2YQ8F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Translation initiation factor SUI1 - - - ko:K03113 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - SUI1 CMS2_k127_2347891_39 929558.SMGD1_0586 2.177e-104 352.0 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,42RQ2@68525|delta/epsilon subdivisions,2YP69@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG2199 FOG GGDEF domain - - - - - - - - - - - - 4HB_MCP_1,GGDEF CMS2_k127_2347891_43 1390370.O203_23635 1.14e-100 358.0 COG0834@1|root,COG5001@1|root,COG0834@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YE8V@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_9,SBP_bac_3 CMS2_k127_2347891_73 1172190.M947_11655 1.137e-34 136.0 COG0607@1|root,COG0607@2|Bacteria,1R70B@1224|Proteobacteria,42UX5@68525|delta/epsilon subdivisions,2YPT0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese-like domain - - - - - - - - - - - - Rhodanese CMS2_k127_2347891_68 929558.SMGD1_2402 3.289e-40 154.0 29ZYE@1|root,30MZZ@2|Bacteria,1Q50E@1224|Proteobacteria,43099@68525|delta/epsilon subdivisions,2YRUG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S SprT-like family - - - - - - - - - - - - SprT-like CMS2_k127_2347891_58 563040.Saut_1744 1.598e-68 244.0 COG4246@1|root,COG4246@2|Bacteria,1RENT@1224|Proteobacteria,42SVX@68525|delta/epsilon subdivisions,2YPPN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Esterase-like activity of phytase - - - - - - - - - - - - Phytase-like CMS2_k127_2347891_76 709032.Sulku_0669 1.67e-30 128.0 COG0454@1|root,COG0456@2|Bacteria,1NPCX@1224|Proteobacteria,42ZWJ@68525|delta/epsilon subdivisions,2YRWX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_7 CMS2_k127_2347891_62 387093.SUN_0742 3.592e-58 205.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,42UF8@68525|delta/epsilon subdivisions,2YPGM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J chain release factor - - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 CMS2_k127_2347891_41 563040.Saut_0427 1.225e-103 345.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,42ME7@68525|delta/epsilon subdivisions,2YMBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG membrane - - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA CMS2_k127_2347891_50 1499967.BAYZ01000080_gene921 2.95e-83 283.0 COG1432@1|root,COG1432@2|Bacteria 2|Bacteria S NYN domain - - - - - - - - - - - - NYN,OST-HTH CMS2_k127_2347891_47 1249480.B649_02075 1.351e-87 298.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2YP3D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA CMS2_k127_2347891_44 929558.SMGD1_2145 5.481e-97 338.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2YNTT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,VWA_2 CMS2_k127_2347891_64 929558.SMGD1_2146 2.368e-49 190.0 COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,42PK9@68525|delta/epsilon subdivisions,2YNXX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Oxygen tolerance - - - - - - - - - - - - BatD CMS2_k127_2347891_16 563040.Saut_0679 1.536e-156 498.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2YMK8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 CMS2_k127_2347891_28 563040.Saut_0680 9.507e-126 408.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,42PJB@68525|delta/epsilon subdivisions,2YNGQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 CMS2_k127_2347891_46 929558.SMGD1_2158 1.18e-92 313.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2YP1P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA CMS2_k127_2347891_26 563040.Saut_0683 8.242e-129 435.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2YNTT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,TPR_8,VWA_2 CMS2_k127_2347891_85 1469557.JSWF01000029_gene3339 2.492e-13 83.0 COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,1HYP9@117743|Flavobacteriia 976|Bacteroidetes S Oxygen tolerance batD - - - - - - - - - - - BatD,TPR_2 CMS2_k127_2347891_38 563040.Saut_0685 2.275e-105 348.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,42MH0@68525|delta/epsilon subdivisions,2YMHS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH CMS2_k127_2347891_56 1537917.JU82_11265 2.181e-74 259.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42NFK@68525|delta/epsilon subdivisions,2YNST@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate CMS2_k127_2347891_5 1165841.SULAR_03272 8.217e-189 597.0 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,42QKD@68525|delta/epsilon subdivisions,2YNHF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulfite dehydrogenase (Cytochrome) subunit SorA apoprotein sorA - - ko:K07147 - - - - ko00000,ko01000 - - - Mo-co_dimer,Oxidored_molyb CMS2_k127_2347891_70 563040.Saut_1023 3.351e-38 145.0 COG2010@1|root,COG2010@2|Bacteria,1NJ3U@1224|Proteobacteria,42W80@68525|delta/epsilon subdivisions,2YQGQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cytochrome C oxidoreductase subunit B - - - - - - - - - - - - - CMS2_k127_2347891_61 1167006.UWK_00896 1.446e-59 211.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2MHKB@213118|Desulfobacterales 28221|Deltaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR CMS2_k127_2347891_3 1537917.JU82_08040 1.01e-276 872.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2YMW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA CMS2_k127_2347891_23 387092.NIS_0408 3.431e-139 457.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2YMVT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FP Guanosine pentaphosphate phosphohydrolase gppA - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA CMS2_k127_2347891_66 387092.NIS_0409 7.171e-44 160.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,42U8W@68525|delta/epsilon subdivisions,2YPVK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin fdxB - - ko:K05337 - - - - ko00000 - - - Fer4 CMS2_k127_2347891_14 929558.SMGD1_2164 3.117e-169 541.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ5@1224|Proteobacteria,42NJC@68525|delta/epsilon subdivisions,2YMGQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase cosS - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA CMS2_k127_2347891_25 563040.Saut_0690 8.926e-131 418.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,42MTC@68525|delta/epsilon subdivisions,2YMSX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain cosR - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C CMS2_k127_2347891_77 1165841.SULAR_06818 4.225e-27 114.0 COG1539@1|root,COG1539@2|Bacteria,1RHII@1224|Proteobacteria,42V1R@68525|delta/epsilon subdivisions,2YQ8Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H dihydroneopterin aldolase folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB CMS2_k127_2347891_52 1537917.JU82_08000 9.11e-82 277.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,42QQP@68525|delta/epsilon subdivisions,2YNZZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf CMS2_k127_2347891_10 563040.Saut_0693 1.121e-177 561.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,42N99@68525|delta/epsilon subdivisions,2YMDU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA CMS2_k127_2347891_29 1249480.B649_02165 1.337e-122 398.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,42MY7@68525|delta/epsilon subdivisions,2YMP6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N CMS2_k127_2347891_17 563040.Saut_0695 1.674e-151 485.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,42NKR@68525|delta/epsilon subdivisions,2YMU1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 CMS2_k127_2347891_55 1249480.B649_02750 1.495e-75 262.0 COG1477@1|root,COG1477@2|Bacteria,1RIPS@1224|Proteobacteria 1224|Proteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE CMS2_k127_2347891_54 1249480.B649_02755 5.826e-76 260.0 COG4659@1|root,COG4659@2|Bacteria,1RFGW@1224|Proteobacteria 1224|Proteobacteria C PFAM FMN-binding domain protein - - - - - - - - - - - - FMN_bind CMS2_k127_2347891_12 1249480.B649_02760 2.073e-172 544.0 28KDQ@1|root,2ZA05@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_2347891_48 1249480.B649_02245 2.113e-85 292.0 COG0618@1|root,COG0618@2|Bacteria,1RADZ@1224|Proteobacteria,43DQA@68525|delta/epsilon subdivisions,2YT8A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DHH family - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 CMS2_k127_2347891_9 929558.SMGD1_2173 8.923e-178 567.0 COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2YMT7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M peptidase M23 - - - - - - - - - - - - Peptidase_M23 CMS2_k127_2347891_75 1123326.JFBL01000007_gene649 7.662e-32 132.0 COG0850@1|root,COG0850@2|Bacteria,1RE6K@1224|Proteobacteria,42X98@68525|delta/epsilon subdivisions,2YQSM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization minC - - ko:K03610 - - - - ko00000,ko03036,ko04812 - - - MinC_C CMS2_k127_2347891_19 929558.SMGD1_2174 1.312e-148 474.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2YMMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC CMS2_k127_2347891_69 1565314.OA34_01165 7.135e-40 153.0 COG1214@1|root,COG1214@2|Bacteria,1Q1J6@1224|Proteobacteria,42TUF@68525|delta/epsilon subdivisions,2YQ3R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG1214 Inactive homolog of metal-dependent proteases tsaB - - - - - - - - - - - - CMS2_k127_2347891_18 929558.SMGD1_2176 2.399e-151 482.0 COG0083@1|root,COG0083@2|Bacteria,1MW8I@1224|Proteobacteria,42M9H@68525|delta/epsilon subdivisions,2YMZ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N CMS2_k127_2347891_84 537970.HCAN_1482 1.454e-15 79.0 COG2740@1|root,COG2740@2|Bacteria,1Q3GD@1224|Proteobacteria,42XA3@68525|delta/epsilon subdivisions,2YQQ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K nucleic-acid-binding protein implicated in transcription termination - - - - - - - - - - - - DUF448 CMS2_k127_2347891_0 929558.SMGD1_2178 0.0 1031.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2YM9V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N CMS2_k127_2347891_65 929558.SMGD1_2179 4.912e-45 167.0 COG0858@1|root,COG0858@2|Bacteria,1Q48R@1224|Proteobacteria,42UQE@68525|delta/epsilon subdivisions,2YPZY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA CMS2_k127_2347891_67 1249480.B649_02285 9.561e-44 165.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,42THF@68525|delta/epsilon subdivisions,2YPXJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C CMS2_k127_2347891_31 1249480.B649_02290 1.797e-117 388.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2YMPP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H riboflavin biosynthesis protein ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 CMS2_k127_2347891_37 326298.Suden_0680 1.474e-105 346.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2YN11@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran CMS2_k127_2347891_20 563040.Saut_0706 6.02e-147 476.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2YMBS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 CMS2_k127_2347891_83 944481.JAFP01000001_gene485 3.361e-16 83.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,42RF8@68525|delta/epsilon subdivisions,2WQRY@28221|Deltaproteobacteria,2M77U@213113|Desulfurellales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg CMS2_k127_2347891_49 572480.Arnit_0394 7.204e-84 291.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42YMW@68525|delta/epsilon subdivisions,2YP3C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs - - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD CMS2_k127_2347891_30 929558.SMGD1_0909 1.884e-120 392.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,42NM9@68525|delta/epsilon subdivisions,2YNQC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short CMS2_k127_2347891_91 1121085.AUCI01000025_gene3035 2.733e-06 55.0 COG2608@1|root,COG2608@2|Bacteria,1VERB@1239|Firmicutes,4HNP0@91061|Bacilli,1ZITG@1386|Bacillus 91061|Bacilli P Copper resistance protein CopZ copZ - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA CMS2_k127_2347891_15 1165841.SULAR_02323 2.142e-160 512.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2YMQ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 CMS2_k127_2347891_87 1172190.M947_09475 3.321e-10 64.0 28PZQ@1|root,2ZCIX@2|Bacteria,1RA7M@1224|Proteobacteria,431D6@68525|delta/epsilon subdivisions,2YSA8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S EF hand - - - - - - - - - - - - EF-hand_5 CMS2_k127_2347891_7 709032.Sulku_2502 1.256e-186 591.0 COG0515@1|root,COG4886@1|root,COG0515@2|Bacteria,COG4886@2|Bacteria,1Q94S@1224|Proteobacteria,42X59@68525|delta/epsilon subdivisions,2YQUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KLT COG4886 Leucine-rich repeat (LRR) protein - - - - - - - - - - - - LRR_4,LRR_8,Pkinase CMS2_k127_2347891_33 929558.SMGD1_1143 1.988e-115 376.0 COG0566@1|root,COG0566@2|Bacteria,1QQ53@1224|Proteobacteria,42R2I@68525|delta/epsilon subdivisions,2YP1Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J SpoU rRNA Methylase family - - - - - - - - - - - - SpoU_methylase CMS2_k127_2347891_21 749222.Nitsa_0232 1.824e-141 459.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2YMCS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 CMS2_k127_2347891_42 1172190.M947_09795 3.333e-101 337.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2YMK1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria OU signal peptide peptidase SppA, 36K type sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 CMS2_k127_2347891_13 929558.SMGD1_2186 5.96e-171 545.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42MJ7@68525|delta/epsilon subdivisions,2YMWU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F COG0402 Cytosine deaminase and related metal-dependent orf1 - 3.5.4.40 ko:K20810 ko00130,ko01110,map00130,map01110 - R10695 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 CMS2_k127_2347891_53 1172190.M947_09770 1.436e-79 267.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,42QU1@68525|delta/epsilon subdivisions,2YNVF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP1038 DHquinase_II CMS2_k127_2347891_63 1165841.SULAR_01693 4.757e-52 188.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2YPJ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK CMS2_k127_2347891_6 709032.Sulku_0475 3.569e-188 596.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,42NBF@68525|delta/epsilon subdivisions,2YN28@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar biosynthesis flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 CMS2_k127_2347891_27 709032.Sulku_0476 6.7e-127 411.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42PF7@68525|delta/epsilon subdivisions,2YM9X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the ParA family flhG - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,ParA CMS2_k127_2347891_80 1249480.B649_02380 5.133e-24 104.0 29NSE@1|root,309QF@2|Bacteria,1QT0N@1224|Proteobacteria,42TIY@68525|delta/epsilon subdivisions,2YP79@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2347891_45 563040.Saut_0716 5.998e-94 313.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,42QQ8@68525|delta/epsilon subdivisions,2YMJ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the sigma-70 factor family fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r4 CMS2_k127_2347891_8 929558.SMGD1_2196 8.73e-185 582.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,42N2Y@68525|delta/epsilon subdivisions,2YMHG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar motor switch protein fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C CMS2_k127_2347891_40 1249480.B649_02395 5.59e-104 345.0 COG1886@1|root,COG1886@2|Bacteria,1NF4E@1224|Proteobacteria,42R4G@68525|delta/epsilon subdivisions,2YN6N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar motor switch protein fliY - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C CMS2_k127_2347891_35 1537917.JU82_06435 2.553e-107 353.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2YNV5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox CMS2_k127_2347891_11 563040.Saut_0719 8.841e-177 561.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2YN0Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans CMS2_k127_2347891_60 697282.Mettu_0367 1.021e-62 220.0 2E6QP@1|root,331AW@2|Bacteria,1N83E@1224|Proteobacteria,1SDRG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2348856_8 563040.Saut_0734 4.946e-14 73.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2YNFG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.20.2.1,1.20.9.1,1.7.7.2 ko:K00367,ko:K00372,ko:K08356 ko00910,ko01120,map00910,map01120 M00531 R00791,R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.6 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS2_k127_2348856_3 357804.Ping_1732 2.406e-147 473.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Magnesium transport protein CorA corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA CMS2_k127_2348856_6 929558.SMGD1_0022 2.854e-64 239.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2YR21@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PAS domain - - - - - - - - - - - - HATPase_c,PAS_9 CMS2_k127_2348856_5 1121403.AUCV01000022_gene3473 1.392e-94 325.0 COG2199@1|root,COG3706@2|Bacteria,1MXBG@1224|Proteobacteria,42NGW@68525|delta/epsilon subdivisions,2WKG6@28221|Deltaproteobacteria,2MMSM@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg CMS2_k127_2348856_1 929558.SMGD1_0402 4.527e-256 803.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,42PHY@68525|delta/epsilon subdivisions,2YMBI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG0155 Sulfite reductase, beta subunit (hemoprotein) - - 1.7.7.1,1.8.7.1 ko:K00366,ko:K00392 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00859,R03600 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr CMS2_k127_2348856_9 525898.Sdel_0481 3.728e-06 54.0 2A488@1|root,30STG@2|Bacteria,1PC82@1224|Proteobacteria,42W1N@68525|delta/epsilon subdivisions,2YQGK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2348856_4 563040.Saut_0736 2.868e-125 403.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2YMCQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase CMS2_k127_2348856_7 1537917.JU82_00935 6.149e-24 102.0 COG1758@1|root,COG1758@2|Bacteria,1Q28G@1224|Proteobacteria,42V5Z@68525|delta/epsilon subdivisions,2YQDH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 CMS2_k127_2348856_0 563040.Saut_0738 1.452e-303 945.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2YN2C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT,HD_4,RelA_SpoT,TGS CMS2_k127_2348856_2 709032.Sulku_1852 3.85e-194 612.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2YMD3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b CMS2_k127_2384755_0 1165841.SULAR_01963 1.907e-140 452.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2YNY0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - His_kinase CMS2_k127_2384755_1 795955.AFRW01000024_gene2292 1.23e-15 83.0 COG3279@1|root,COG3279@2|Bacteria,2IPFZ@201174|Actinobacteria 201174|Actinobacteria K Response regulator receiver - - - ko:K02477,ko:K07705 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg CMS2_k127_2390221_1 351348.Maqu_1265 5.932e-16 79.0 arCOG07807@1|root,32S82@2|Bacteria,1RDIN@1224|Proteobacteria,1SDFY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF2971 CMS2_k127_2390221_0 1479237.JMLY01000001_gene464 2.598e-91 310.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,465IU@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase IS116/IS110/IS902 family Z012_08285 - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 CMS2_k127_2390221_2 204773.HEAR2138 6.812e-11 68.0 2D5JP@1|root,3374Q@2|Bacteria,1NBJT@1224|Proteobacteria,2W2H6@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2451171_2 929558.SMGD1_0892 1.457e-40 151.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,42RDQ@68525|delta/epsilon subdivisions,2YP65@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 CMS2_k127_2451171_0 1537917.JU82_01665 0.0 2561.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2YMP9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 CMS2_k127_2451171_1 1165841.SULAR_10369 0.0 1701.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2YMMS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 CMS2_k127_245605_4 1249480.B649_01275 9.034e-118 394.0 COG4773@1|root,COG4773@2|Bacteria,1QZMX@1224|Proteobacteria,42SA0@68525|delta/epsilon subdivisions,2YPCD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - - CMS2_k127_245605_7 1165841.SULAR_07088 6.522e-85 285.0 COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2YM8K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate ribA - 3.5.4.25 ko:K01497 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125 R00425 RC00293,RC02504 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydro2 CMS2_k127_245605_1 326298.Suden_0385 3.57e-171 541.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2YMV6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD CMS2_k127_245605_9 1249480.B649_01930 3.223e-63 244.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,43CEF@68525|delta/epsilon subdivisions,2YTC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF CMS2_k127_245605_3 1537917.JU82_02645 1.259e-154 492.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,42M0Q@68525|delta/epsilon subdivisions,2YMXU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS2_k127_245605_15 1249480.B649_10225 2.467e-17 84.0 2A4UE@1|root,30TFZ@2|Bacteria,1PDA5@1224|Proteobacteria,42WVN@68525|delta/epsilon subdivisions,2YQRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_245605_2 563040.Saut_0356 2.256e-159 508.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2YMK7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b CMS2_k127_245605_11 326298.Suden_0391 1.455e-57 203.0 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,42ST2@68525|delta/epsilon subdivisions,2YPG7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane - - - ko:K08973 - - - - ko00000 - - - UPF0093 CMS2_k127_245605_0 563040.Saut_0361 8.921e-210 665.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2YMQ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 CMS2_k127_245605_8 1172190.M947_09295 5.334e-78 274.0 COG0741@1|root,COG0741@2|Bacteria,1MW2T@1224|Proteobacteria,42M1M@68525|delta/epsilon subdivisions,2YNEQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Membrane-bound lytic murein transglycosylase C mltC - - ko:K08306 - - - - ko00000,ko01000,ko01011 - GH23 - DUF3393,SLT CMS2_k127_245605_13 1172190.M947_06660 2.409e-54 197.0 2BN8J@1|root,32GW0@2|Bacteria,1RH74@1224|Proteobacteria,42W5Z@68525|delta/epsilon subdivisions,2YQ9Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S LPP20 lipoprotein - - - - - - - - - - - - LPP20 CMS2_k127_245605_10 690850.Desaf_3539 1.674e-60 222.0 2A4AM@1|root,30SW8@2|Bacteria,1PCDH@1224|Proteobacteria,4331M@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_245605_14 690850.Desaf_3538 6.173e-25 116.0 2EJXW@1|root,33DNI@2|Bacteria,1NJTD@1224|Proteobacteria,42XYW@68525|delta/epsilon subdivisions 1224|Proteobacteria S LPP20 lipoprotein - - - - - - - - - - - - LPP20 CMS2_k127_245605_5 1150621.SMUL_2449 7.624e-103 351.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,42M92@68525|delta/epsilon subdivisions,2YN0J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel CMS2_k127_245605_12 387093.SUN_1505 8.389e-57 202.0 COG2236@1|root,COG2236@2|Bacteria,1Q1HY@1224|Proteobacteria,42TR4@68525|delta/epsilon subdivisions,2YP9B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F phosphoribosyltransferase gpt - 2.4.2.22 ko:K00769 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01229,R02142 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran CMS2_k127_245605_6 326298.Suden_0341 6.083e-100 334.0 COG0679@1|root,COG0679@2|Bacteria,1N5NC@1224|Proteobacteria,42PYE@68525|delta/epsilon subdivisions,2YMUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans CMS2_k127_2458610_1 1249480.B649_03655 3.519e-63 220.0 COG0433@1|root,COG0433@2|Bacteria,1Q4H7@1224|Proteobacteria,42Z6M@68525|delta/epsilon subdivisions,2YR7W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0433 Predicted ATPase - - - - - - - - - - - - - CMS2_k127_2458610_2 195250.CM001776_gene231 3.08e-27 116.0 2DHTP@1|root,300X5@2|Bacteria,1GPJ9@1117|Cyanobacteria,1H3D8@1129|Synechococcus 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS2_k127_2458610_0 796606.BMMGA3_09025 4.979e-110 373.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1ZAVY@1386|Bacillus 91061|Bacilli T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_9 CMS2_k127_2549659_0 1123326.JFBL01000019_gene2270 2.057e-175 557.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YMN1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C CMS2_k127_2549659_1 1165841.SULAR_03302 4.685e-71 242.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,42SI7@68525|delta/epsilon subdivisions,2YP7Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0178 family - - - ko:K09768 - - - - ko00000 - - - DUF188 CMS2_k127_2549659_2 326298.Suden_0141 2.32e-12 67.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YNK5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DEAD box helicase family dbpA - 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C CMS2_k127_257884_4 929558.SMGD1_2348 1.528e-167 533.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2YMEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin CMS2_k127_257884_25 1249480.B649_07785 3.023e-35 136.0 COG2214@1|root,COG2214@2|Bacteria,1QXNV@1224|Proteobacteria,42X9T@68525|delta/epsilon subdivisions 1224|Proteobacteria O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ CMS2_k127_257884_30 397290.C810_04281 0.0001525 47.0 COG1352@1|root,COG1352@2|Bacteria,1TPD8@1239|Firmicutes,24AQJ@186801|Clostridia,27IP1@186928|unclassified Lachnospiraceae 186801|Clostridia NT Methyltransferase, chemotaxis proteins cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N CMS2_k127_257884_9 387092.NIS_1034 9.776e-106 350.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2YNB7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q abc transporter atp-binding protein - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran CMS2_k127_257884_24 1537917.JU82_11305 2.595e-35 140.0 2FGS9@1|root,348MQ@2|Bacteria,1P3H2@1224|Proteobacteria,42SDS@68525|delta/epsilon subdivisions,2YPE7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane - - - - - - - - - - - - DUF4149 CMS2_k127_257884_12 709032.Sulku_0856 5.851e-87 295.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2YP35@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the protein N5-glutamine methyltransferase family hemK - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS CMS2_k127_257884_3 929558.SMGD1_0041 1.371e-169 541.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2YN96@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Peptidase M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N CMS2_k127_257884_7 929558.SMGD1_2835 7.649e-129 425.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,42PV5@68525|delta/epsilon subdivisions,2YMVK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Mate efflux family protein - - - - - - - - - - - - MatE CMS2_k127_257884_26 1537917.JU82_11440 2.414e-15 80.0 2AJ62@1|root,319QQ@2|Bacteria,1Q3M5@1224|Proteobacteria,42XHG@68525|delta/epsilon subdivisions,2YQWM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_257884_1 929558.SMGD1_2398 3.123e-295 917.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2YMXZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ABC transporter, ATP-binding protein - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn CMS2_k127_257884_20 929558.SMGD1_0711 2.889e-51 186.0 COG0526@1|root,COG0526@2|Bacteria,1RHPC@1224|Proteobacteria,42UEQ@68525|delta/epsilon subdivisions,2YPZQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA CMS2_k127_257884_22 1116472.MGMO_155c00170 9.097e-42 159.0 COG0454@1|root,COG0456@2|Bacteria,1PGPM@1224|Proteobacteria,1TC01@1236|Gammaproteobacteria,1XGT3@135618|Methylococcales 135618|Methylococcales K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 CMS2_k127_257884_27 983548.Krodi_2609 2.857e-12 72.0 2EM6Y@1|root,33EW5@2|Bacteria,4P5V8@976|Bacteroidetes,1IAUS@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_257884_10 1165841.SULAR_10644 9.544e-90 302.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2YNZT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P CMS2_k127_257884_23 1121434.AULY01000007_gene1272 1.78e-38 146.0 2DNS2@1|root,32YVY@2|Bacteria,1N9QQ@1224|Proteobacteria,42X5E@68525|delta/epsilon subdivisions,2X2FX@28221|Deltaproteobacteria,2MDGG@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_257884_19 1121434.AULY01000007_gene1271 1.433e-53 192.0 2C3ZE@1|root,32TE1@2|Bacteria,1MZNB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_257884_28 1249480.B649_05640 6.584e-09 59.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2YPQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Transposase - - - - - - - - - - - - Y1_Tnp CMS2_k127_257884_8 563040.Saut_0489 1.114e-117 381.0 2AINN@1|root,31954@2|Bacteria,1NDHA@1224|Proteobacteria,42Z7Y@68525|delta/epsilon subdivisions,2YR4T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF4395) - - - - - - - - - - - - DUF4395 CMS2_k127_257884_14 90813.JQMT01000001_gene1084 1.658e-75 258.0 COG2824@1|root,COG2824@2|Bacteria,1RGUU@1224|Proteobacteria,1S60W@1236|Gammaproteobacteria,462BF@72273|Thiotrichales 72273|Thiotrichales P PhnA Zinc-Ribbon - - - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon CMS2_k127_257884_11 929558.SMGD1_2585 9.843e-90 306.0 29CAW@1|root,2ZZ9C@2|Bacteria,1Q5FH@1224|Proteobacteria,42Q2S@68525|delta/epsilon subdivisions,2YP18@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_257884_21 1537917.JU82_09285 2.158e-42 158.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2YT6X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T DnaK suppressor protein dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR CMS2_k127_257884_18 929558.SMGD1_2583 7.066e-58 204.0 COG1576@1|root,COG1576@2|Bacteria,1N7WB@1224|Proteobacteria,42V41@68525|delta/epsilon subdivisions,2YP43@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase CMS2_k127_257884_16 326298.Suden_1173 1.936e-70 243.0 COG0352@1|root,COG0352@2|Bacteria,1Q57E@1224|Proteobacteria,42T8S@68525|delta/epsilon subdivisions,2YPQM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Thiamine monophosphate synthase thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI CMS2_k127_257884_6 709032.Sulku_1129 9.679e-139 446.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,42MAB@68525|delta/epsilon subdivisions,2YN34@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans CMS2_k127_257884_15 387092.NIS_1199 1.667e-72 251.0 COG0483@1|root,COG0483@2|Bacteria,1Q17W@1224|Proteobacteria,42T1U@68525|delta/epsilon subdivisions,2YPGV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P CMS2_k127_257884_2 709032.Sulku_1127 1.3e-237 740.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2YN2P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2,Pyr_redox_3 CMS2_k127_257884_0 1537917.JU82_09320 0.0 2248.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2YMRQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase CMS2_k127_257884_13 1537917.JU82_09325 2.939e-80 272.0 COG1381@1|root,COG1381@2|Bacteria,1QAJR@1224|Proteobacteria,42NUJ@68525|delta/epsilon subdivisions,2YPCX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L RecO N terminal - - - - - - - - - - - - RecO_N_2 CMS2_k127_257884_5 1123326.JFBL01000016_gene2522 3.288e-158 506.0 2C76X@1|root,2ZM1W@2|Bacteria,1P5JD@1224|Proteobacteria,42P9T@68525|delta/epsilon subdivisions,2YMRC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_257884_17 1165841.SULAR_01563 6.265e-68 239.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42Z0P@68525|delta/epsilon subdivisions,2YR4F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0513 Superfamily II DNA and RNA - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C CMS2_k127_2595511_1 563040.Saut_1036 1.011e-44 168.0 COG4659@1|root,COG4659@2|Bacteria,1NP43@1224|Proteobacteria,43BHC@68525|delta/epsilon subdivisions,2YQ00@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C FMN binding - - - - - - - - - - - - - CMS2_k127_2595511_0 1165841.SULAR_06073 6.281e-123 407.0 COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,42RB0@68525|delta/epsilon subdivisions,2YNE9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Pfam Transposase IS66 - - - - - - - - - - - - Porin_O_P CMS2_k127_2665441_2 563040.Saut_0398 3.487e-190 608.0 2C99Z@1|root,2Z9YV@2|Bacteria,1N0B7@1224|Proteobacteria,42P3M@68525|delta/epsilon subdivisions,2YMWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3373) - - - - - - - - - - - - DUF3373 CMS2_k127_2665441_9 563040.Saut_0394 1.178e-82 276.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2YNVV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O bacterioferritin comigratory protein bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA CMS2_k127_2665441_15 929558.SMGD1_1569 6.276e-20 92.0 COG1683@1|root,COG1683@2|Bacteria,1R356@1224|Proteobacteria,43DJ6@68525|delta/epsilon subdivisions,2YPYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF523) - - - - - - - - - - - - DUF523 CMS2_k127_2665441_16 1172190.M947_06225 9.392e-18 83.0 COG1683@1|root,COG1683@2|Bacteria,1R356@1224|Proteobacteria,43DJ6@68525|delta/epsilon subdivisions,2YPYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF523) - - - - - - - - - - - - DUF523 CMS2_k127_2665441_1 929558.SMGD1_1568 4.974e-241 751.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2YMDS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh CMS2_k127_2665441_10 1537917.JU82_06600 3.955e-61 213.0 COG2346@1|root,COG2346@2|Bacteria,1Q5UZ@1224|Proteobacteria,42U39@68525|delta/epsilon subdivisions,2YPTS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG2346 Truncated hemoglobins - - - ko:K06886 - - - - ko00000 - - - Bac_globin CMS2_k127_2665441_3 929558.SMGD1_1630 1.134e-171 541.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2YMGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 CMS2_k127_2665441_6 563040.Saut_1861 1.549e-144 467.0 COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,42MNX@68525|delta/epsilon subdivisions,2YME9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG0330 Membrane protease subunits stomatin prohibitin homologs - - - - - - - - - - - - Band_7 CMS2_k127_2665441_8 1537917.JU82_06585 3.458e-111 363.0 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2YNQD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Histidine biosynthesis bifunctional protein hisIE hisI - 3.5.4.19,3.6.1.31 ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH CMS2_k127_2665441_14 929558.SMGD1_1633 7.475e-31 127.0 2AK36@1|root,31ASY@2|Bacteria,1Q62K@1224|Proteobacteria,42W11@68525|delta/epsilon subdivisions,2YQDG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF2393) - - - - - - - - - - - - DUF2393 CMS2_k127_2665441_13 929558.SMGD1_1634 2.747e-45 170.0 2AJSF@1|root,30P8S@2|Bacteria,1PCR0@1224|Proteobacteria,42WCR@68525|delta/epsilon subdivisions,2YSXN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF2393) - - - - - - - - - - - - DUF2393 CMS2_k127_2665441_4 563040.Saut_1857 1.374e-164 522.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,42PX9@68525|delta/epsilon subdivisions,2YN2U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Radical SAM protein - - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C CMS2_k127_2665441_0 1249480.B649_00940 8.125e-250 777.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2YMF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran CMS2_k127_2665441_7 929558.SMGD1_1637 5.297e-126 407.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,42N84@68525|delta/epsilon subdivisions,2YM7V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0510 DapB_C,DapB_N CMS2_k127_2665441_5 929558.SMGD1_1638 4.834e-153 488.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2YN1K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS2_k127_2665441_12 929558.SMGD1_1639 2.782e-50 183.0 2AIG0@1|root,318XK@2|Bacteria,1Q14Q@1224|Proteobacteria,42SW7@68525|delta/epsilon subdivisions,2YPQ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2665441_11 1537917.JU82_08045 1.901e-55 194.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2YPES@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the thioredoxin family trx2 - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin CMS2_k127_2665630_0 1172190.M947_07350 1.554e-208 655.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2YMUV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY CMS2_k127_2665630_1 563040.Saut_0235 3.274e-135 433.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2YM98@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 CMS2_k127_2665630_4 326298.Suden_0307 7.34e-41 151.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions,2YPS3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a CMS2_k127_2665630_6 290340.AAur_1630 5.667e-39 160.0 COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria 201174|Actinobacteria I fatty acid desaturase - - - - - - - - - - - - FA_desaturase CMS2_k127_2665630_2 1165841.SULAR_01160 4.488e-106 353.0 COG1231@1|root,COG1231@2|Bacteria,1P3D9@1224|Proteobacteria,42PT0@68525|delta/epsilon subdivisions 1224|Proteobacteria E PFAM amine oxidase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase,NAD_binding_8 CMS2_k127_2665630_7 1165841.SULAR_10674 1.488e-32 128.0 2DDD8@1|root,2ZHK8@2|Bacteria,1Q56G@1224|Proteobacteria,42V7B@68525|delta/epsilon subdivisions,2YQI8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulphur oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ CMS2_k127_2665630_5 1165841.SULAR_10679 2.003e-39 152.0 COG5501@1|root,COG5501@2|Bacteria 2|Bacteria - - soxY - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY,SoxZ CMS2_k127_2665630_9 1249480.B649_06210 8.436e-25 106.0 COG2863@1|root,COG2863@2|Bacteria,1NFMX@1224|Proteobacteria,42VGD@68525|delta/epsilon subdivisions 1224|Proteobacteria C cytochrome cyf GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 CMS2_k127_2665630_8 1249480.B649_10455 2.058e-32 129.0 28QM5@1|root,2ZD2X@2|Bacteria,1P3YE@1224|Proteobacteria,42WN9@68525|delta/epsilon subdivisions,2YQE1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_2665630_10 326298.Suden_1582 1.477e-20 92.0 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,42VC4@68525|delta/epsilon subdivisions,2YQTY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1773 Rubredoxin - - - - - - - - - - - - Rubredoxin CMS2_k127_2665630_3 944547.ABLL_2164 5.112e-88 301.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,42N7I@68525|delta/epsilon subdivisions,2YMDW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase CMS2_k127_2682195_6 929558.SMGD1_0351 2.609e-53 189.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42N29@68525|delta/epsilon subdivisions,2YMFM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA helicase rep - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C CMS2_k127_2682195_8 1537917.JU82_08675 7.006e-39 148.0 COG1699@1|root,COG1699@2|Bacteria,1N347@1224|Proteobacteria,42RNU@68525|delta/epsilon subdivisions,2YPKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW CMS2_k127_2682195_0 709032.Sulku_0712 0.0 1442.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2YM8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 CMS2_k127_2682195_1 563040.Saut_1463 1.926e-230 723.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,42MQD@68525|delta/epsilon subdivisions,2YNHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0659 Sulfate permease and related - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp CMS2_k127_2682195_2 944547.ABLL_1601 2.607e-125 425.0 COG5001@1|root,COG5001@2|Bacteria,1R4H0@1224|Proteobacteria,43CII@68525|delta/epsilon subdivisions,2YTD5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF CMS2_k127_2682195_3 717231.Flexsi_1485 6.851e-92 319.0 COG1305@1|root,COG1305@2|Bacteria,2GGQD@200930|Deferribacteres 200930|Deferribacteres E Transglutaminase-like - - - - - - - - - - - - - CMS2_k127_2682195_4 563040.Saut_1466 8.611e-91 305.0 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,42MJW@68525|delta/epsilon subdivisions,2YN3R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH CMS2_k127_2682195_7 929558.SMGD1_0367 1.461e-49 181.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2YPDX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S GatB Yqey family protein - - - ko:K09117 - - - - ko00000 - - - YqeY CMS2_k127_282537_11 935837.JAEK01000090_gene445 0.0003641 43.0 29S70@1|root,30DBH@2|Bacteria,1UB40@1239|Firmicutes,4IMGK@91061|Bacilli,1ZK45@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - CMS2_k127_282537_5 326298.Suden_1652 1.07e-59 208.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42UQ6@68525|delta/epsilon subdivisions,2YQ4Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT PFAM PAS fold-3 domain protein - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - PAS_3 CMS2_k127_282537_1 929558.SMGD1_2114 1.183e-131 429.0 COG0840@1|root,COG0840@2|Bacteria,1PNV4@1224|Proteobacteria,42YFX@68525|delta/epsilon subdivisions,2YRME@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal CMS2_k127_282537_4 709032.Sulku_1649 9.778e-92 306.0 COG1051@1|root,COG1051@2|Bacteria,1PNK8@1224|Proteobacteria,42YE5@68525|delta/epsilon subdivisions,2YR8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F NUDIX domain - - 3.6.1.62,3.6.1.64 ko:K16855 ko00230,ko03018,map00230,map03018 - R00961,R10235,R10815 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX CMS2_k127_282537_2 563040.Saut_0115 6.442e-92 310.0 COG0697@1|root,COG0697@2|Bacteria,1R8RU@1224|Proteobacteria,42SDJ@68525|delta/epsilon subdivisions,2YPDW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA CMS2_k127_282537_3 563040.Saut_0324 6.943e-92 308.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,42N66@68525|delta/epsilon subdivisions,2YMY7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N CMS2_k127_282537_10 316067.Geob_3305 1.226e-05 51.0 COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,42X22@68525|delta/epsilon subdivisions,2WSMI@28221|Deltaproteobacteria,43VN8@69541|Desulfuromonadales 28221|Deltaproteobacteria C Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM CMS2_k127_282537_7 929558.SMGD1_0027 4.855e-17 86.0 COG2201@1|root,COG2201@2|Bacteria 2|Bacteria NT protein-glutamate methylesterase activity - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - GGDEF,Response_reg CMS2_k127_282537_9 436114.SYO3AOP1_0584 5.31e-16 85.0 COG3150@1|root,COG3150@2|Bacteria 2|Bacteria G esterase yqiA GO:0003674,GO:0003824,GO:0016787,GO:0016788 - ko:K07000 - - - - ko00000 - - - UPF0227 CMS2_k127_282537_0 563040.Saut_0326 1.334e-181 573.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,42MKD@68525|delta/epsilon subdivisions,2YMRD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 CMS2_k127_282537_6 563040.Saut_0327 7.155e-51 183.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2YMKA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase CMS2_k127_28749_21 1307437.J139_19514 1.788e-12 81.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RS1Z@1236|Gammaproteobacteria,2Q5M3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - 4.2.2.3 ko:K01729 ko00051,map00051 - R03706 - ko00000,ko00001,ko01000 - - - Chondroitinas_B,Polysacc_lyase CMS2_k127_28749_20 1270193.JARP01000005_gene3940 3.068e-15 90.0 COG3291@1|root,COG5184@1|root,COG3291@2|Bacteria,COG5184@2|Bacteria,4PFH9@976|Bacteroidetes,1ICE3@117743|Flavobacteriia,2NWTH@237|Flavobacterium 976|Bacteroidetes DZ regulator of chromosome condensation, RCC1 - - - - - - - - - - - - - CMS2_k127_28749_22 1111728.ATYS01000021_gene3860 1.367e-09 72.0 COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q von willebrand factor, type A lapA - - ko:K12549 - - - - ko00000 - - - Big_3_2,Cadherin_3,Calx-beta,HemolysinCabind,VCBS,VWA,VWA_2 CMS2_k127_28749_18 525898.Sdel_0795 4.224e-29 124.0 COG2197@1|root,COG2197@2|Bacteria,1N8MU@1224|Proteobacteria,42U0R@68525|delta/epsilon subdivisions,2YT2Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE CMS2_k127_28749_6 525898.Sdel_0794 8.038e-152 492.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,42MCZ@68525|delta/epsilon subdivisions,2YNNG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M type I secretion membrane fusion protein, HlyD family - - - ko:K02022,ko:K12542 - M00330 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1 - - Biotin_lipoyl_2,HlyD_3 CMS2_k127_28749_0 1537915.JU57_05160 1.107e-270 850.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,42MP9@68525|delta/epsilon subdivisions,2YMN8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Type I secretion system ATPase - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran CMS2_k127_28749_5 1537917.JU82_11630 3.873e-154 507.0 COG1538@1|root,COG2885@1|root,COG1538@2|Bacteria,COG2885@2|Bacteria,1MYX2@1224|Proteobacteria,42Q7M@68525|delta/epsilon subdivisions,2YNPH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU outer membrane protein, TolC family - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP CMS2_k127_28749_8 563040.Saut_0955 9.246e-106 346.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2YN1G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C CMS2_k127_28749_14 929558.SMGD1_0096 2.117e-58 210.0 COG1521@1|root,COG1521@2|Bacteria,1PZXA@1224|Proteobacteria,42RA8@68525|delta/epsilon subdivisions,2YP14@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase CMS2_k127_28749_17 563040.Saut_0953 2.153e-30 123.0 2BQJ4@1|root,32JEZ@2|Bacteria,1Q29Y@1224|Proteobacteria,42V8X@68525|delta/epsilon subdivisions,2YQIT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_28749_7 1249480.B649_05020 9.939e-115 376.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2YT9X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules xerH - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase CMS2_k127_28749_10 929558.SMGD1_2440 1.795e-79 276.0 2AGMT@1|root,316V3@2|Bacteria,1PY20@1224|Proteobacteria,42NND@68525|delta/epsilon subdivisions,2YMQB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - pgbB - - - - - - - - - - - PGBA_C,PQQ_2 CMS2_k127_28749_16 1249480.B649_05010 1.585e-41 160.0 COG4649@1|root,COG4649@2|Bacteria,1Q2HI@1224|Proteobacteria,42VQJ@68525|delta/epsilon subdivisions,2YQ7B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - TPR_21 CMS2_k127_28749_19 563040.Saut_1365 4.665e-28 116.0 COG0721@1|root,COG0721@2|Bacteria,1Q61J@1224|Proteobacteria,42VIQ@68525|delta/epsilon subdivisions,2YQAY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln CMS2_k127_28749_15 563040.Saut_1366 1.189e-42 158.0 COG1393@1|root,COG1393@2|Bacteria,1QA5B@1224|Proteobacteria,42UFC@68525|delta/epsilon subdivisions,2YPVT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the ArsC family - - - - - - - - - - - - ArsC CMS2_k127_28749_4 1249480.B649_04995 1.585e-186 587.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2YMY9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU twitching motility protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS2_k127_28749_2 929558.SMGD1_2396 5.917e-231 722.0 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,42MB5@68525|delta/epsilon subdivisions,2YMRI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E phospho-2-dehydro-3-deoxyheptonate aldolase aroG - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0134 DAHP_synth_2 CMS2_k127_28749_13 326298.Suden_1270 9.792e-62 223.0 COG2199@1|root,COG2199@2|Bacteria,1N1BS@1224|Proteobacteria,42T9K@68525|delta/epsilon subdivisions,2YPNM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF CMS2_k127_28749_12 326298.Suden_1271 1.835e-63 224.0 COG1286@1|root,COG1286@2|Bacteria,1NIBK@1224|Proteobacteria,42U0P@68525|delta/epsilon subdivisions,2YPS8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Colicin V production protein cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V CMS2_k127_28749_11 563040.Saut_1400 6.84e-71 243.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2YPGX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the Fur family fur GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03711 - - - - ko00000,ko03000 - - - FUR CMS2_k127_28749_3 1165841.SULAR_09054 2.022e-226 711.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2YMR5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon CMS2_k127_28749_1 1165841.SULAR_09059 6.148e-242 751.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2YMEX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0183 SHMT CMS2_k127_28749_9 929558.SMGD1_2388 1.54e-99 326.0 COG4951@1|root,COG4951@2|Bacteria,1PC94@1224|Proteobacteria,42NUB@68525|delta/epsilon subdivisions,2YMWW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Domain of unknown function (DUF1882) - - - - - - - - - - - - DUF1882 CMS2_k127_28749_23 1123326.JFBL01000013_gene389 2.72e-05 47.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2YTQI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase CMS2_k127_2968536_3 563040.Saut_1644 1.503e-137 441.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2YM7I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0354 DXP_synthase_N,Transket_pyr,Transketolase_C CMS2_k127_2968536_5 709032.Sulku_0348 6.783e-108 351.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2YMW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Alkyl hydroperoxide reductase ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA CMS2_k127_2968536_0 929558.SMGD1_1751 3.689e-209 656.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2YMJU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N CMS2_k127_2968536_7 1165841.SULAR_06938 5.402e-61 211.0 COG1145@1|root,COG1145@2|Bacteria,1QZ2K@1224|Proteobacteria,42SFI@68525|delta/epsilon subdivisions,2YPQC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7 CMS2_k127_2968536_6 563040.Saut_0512 1.423e-69 237.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2YP3Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK CMS2_k127_2968536_9 709032.Sulku_2160 4.863e-32 128.0 COG1399@1|root,COG1399@2|Bacteria,1Q1I8@1224|Proteobacteria,42TRP@68525|delta/epsilon subdivisions,2YQ23@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S metal-binding, possibly nucleic acid-binding protein - - - - - - - - - - - - DUF177 CMS2_k127_2968536_11 387092.NIS_0397 2.448e-23 99.0 COG0333@1|root,COG0333@2|Bacteria,1PU3Z@1224|Proteobacteria,42VA5@68525|delta/epsilon subdivisions,2YQ6U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p CMS2_k127_2968536_1 1537917.JU82_02675 1.083e-168 534.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,42NRV@68525|delta/epsilon subdivisions,2YMK2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis CMS2_k127_2968536_2 1249480.B649_10210 5.849e-165 523.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2YMMA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iIT341.HP0202 ACP_syn_III,ACP_syn_III_C CMS2_k127_2968536_10 709032.Sulku_1645 6.163e-29 123.0 COG1651@1|root,COG1651@2|Bacteria,1Q684@1224|Proteobacteria,432K4@68525|delta/epsilon subdivisions,2YSQB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - - - - - - - - - - - CMS2_k127_2968536_4 709032.Sulku_1646 1.027e-127 434.0 COG1033@1|root,COG1033@2|Bacteria 2|Bacteria S growth of symbiont in host cell - - - ko:K07003 - - - - ko00000 - - - MMPL CMS2_k127_2968536_8 929558.SMGD1_2571 1.922e-55 204.0 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2YMRX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Signal transduction protein - - - - - - - - - - - - HDOD CMS2_k127_30291_3 929558.SMGD1_2265 2.066e-17 82.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2YMZQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 CMS2_k127_30291_2 944546.ABED_1488 2.207e-66 232.0 COG0340@1|root,COG0340@2|Bacteria,1Q1NZ@1224|Proteobacteria,42RQM@68525|delta/epsilon subdivisions,2YP5C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H biotin acetyl-CoA-carboxylase ligase birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_LplA_LipB CMS2_k127_30291_0 929558.SMGD1_2263 5.789e-122 398.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2YMQZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N CMS2_k127_30291_1 709032.Sulku_0749 1.419e-112 368.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2YN5P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA CMS2_k127_303477_0 1172190.M947_10595 7.355e-198 619.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,42M43@68525|delta/epsilon subdivisions,2YM8G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the aconitase IPM isomerase family acnB GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0045333,GO:0046395,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:0097159,GO:1901363,GO:1901575 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N CMS2_k127_3069469_0 929558.SMGD1_0987 4.025e-151 480.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2YN0T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C CMS2_k127_3069469_1 563040.Saut_0217 3.418e-43 158.0 COG0089@1|root,COG0089@2|Bacteria,1QJHM@1224|Proteobacteria,42TRQ@68525|delta/epsilon subdivisions,2YPUJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 CMS2_k127_3071548_27 387092.NIS_1550 1.374e-17 82.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2YPES@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the thioredoxin family trx2 - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin CMS2_k127_3071548_25 929558.SMGD1_1565 1.097e-29 121.0 COG0792@1|root,COG0792@2|Bacteria,1Q27V@1224|Proteobacteria,42V4E@68525|delta/epsilon subdivisions,2YQJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 CMS2_k127_3071548_1 1165841.SULAR_09839 0.0 1268.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2YMS1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhF - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS2_k127_3071548_4 929558.SMGD1_1563 3.033e-198 625.0 COG0460@1|root,COG2716@1|root,COG0460@2|Bacteria,COG2716@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2YMUK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 CMS2_k127_3071548_3 1172190.M947_06195 1.152e-231 720.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2YMMY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_3071548_15 563040.Saut_1913 1.337e-81 280.0 2AIIS@1|root,3190V@2|Bacteria,1Q1CZ@1224|Proteobacteria,42TB4@68525|delta/epsilon subdivisions,2YPN5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3071548_23 929558.SMGD1_1560 1.436e-42 166.0 COG1426@1|root,COG1426@2|Bacteria,1Q33C@1224|Proteobacteria,42WQB@68525|delta/epsilon subdivisions,2YQFX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - CMS2_k127_3071548_14 563040.Saut_1915 1.523e-84 285.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42MZF@68525|delta/epsilon subdivisions,2YMQX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind CMS2_k127_3071548_9 929558.SMGD1_1558 5.857e-121 393.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2YMYB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase CMS2_k127_3071548_24 709032.Sulku_2304 1.045e-30 123.0 COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2YQ19@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 CMS2_k127_3071548_16 326298.Suden_1911 3.315e-75 258.0 COG1385@1|root,COG1385@2|Bacteria,1QDSD@1224|Proteobacteria,42S1W@68525|delta/epsilon subdivisions,2YP9M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA CMS2_k127_3071548_7 326298.Suden_1912 1.76e-138 452.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2YMM3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin biosynthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N CMS2_k127_3071548_13 1249480.B649_10890 1.427e-88 295.0 COG0720@1|root,COG0720@2|Bacteria,1R62M@1224|Proteobacteria,42R4Z@68525|delta/epsilon subdivisions,2YNZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS CMS2_k127_3071548_10 563040.Saut_1922 1.079e-106 351.0 COG0602@1|root,COG0602@2|Bacteria,1PDNI@1224|Proteobacteria,42R24@68525|delta/epsilon subdivisions,2YN2N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14 CMS2_k127_3071548_5 1537917.JU82_01885 1.157e-177 559.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2YM8U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM CMS2_k127_3071548_12 1537917.JU82_02910 2.679e-91 308.0 28M05@1|root,2ZAF9@2|Bacteria,1MY5U@1224|Proteobacteria,42QPW@68525|delta/epsilon subdivisions,2YP0Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S General glycosylation pathway protein - - - - - - - - - - - - - CMS2_k127_3071548_6 929558.SMGD1_0421 1.82e-140 449.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42QRU@68525|delta/epsilon subdivisions,2YMXG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter - - - ko:K15555,ko:K15578 ko00910,ko00920,ko02010,map00910,map00920,map02010 M00436,M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.1,3.A.1.17.2 - - ABC_tran CMS2_k127_3071548_8 929558.SMGD1_0420 2.073e-133 428.0 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,42Q2R@68525|delta/epsilon subdivisions,2YNDK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0600 ABC-type nitrate sulfonate bicarbonate transport system permease component - - - ko:K15577 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - BPD_transp_1 CMS2_k127_3071548_2 1165841.SULAR_09309 2.203e-266 824.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,42PB4@68525|delta/epsilon subdivisions,2YNJ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 CMS2_k127_3071548_11 709032.Sulku_1382 2.491e-93 321.0 2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,42QBG@68525|delta/epsilon subdivisions,2YNTS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - Alginate_exp CMS2_k127_3071548_26 929558.SMGD1_0596 7.349e-26 109.0 29EHP@1|root,301FM@2|Bacteria,1Q6TI@1224|Proteobacteria,433SJ@68525|delta/epsilon subdivisions,2YSVK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3071548_21 929558.SMGD1_0595 8.59e-54 191.0 COG3062@1|root,COG3062@2|Bacteria,1NGMR@1224|Proteobacteria,42UEZ@68525|delta/epsilon subdivisions,2YPWT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P nitrate reductase napD - - ko:K02570 - - - - ko00000 - - - NapD CMS2_k127_3071548_20 1172190.M947_04905 1.817e-60 214.0 COG1149@1|root,COG1149@2|Bacteria,1QZ2E@1224|Proteobacteria,42TQN@68525|delta/epsilon subdivisions,2YPUZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C ferredoxin-type protein NapF napF - - ko:K02572 - - - - ko00000 - - - Fer4 CMS2_k127_3071548_17 929558.SMGD1_0592 1.027e-67 237.0 COG3043@1|root,COG3043@2|Bacteria,1NAZB@1224|Proteobacteria,42SN1@68525|delta/epsilon subdivisions,2YPF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Electron transfer subunit of the periplasmic nitrate reductase complex NapAB napB - - ko:K02568 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798 RC02812 ko00000,ko00001,ko00002 - - - NapB CMS2_k127_3071548_0 326298.Suden_1514 0.0 1673.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2YMEW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC napA - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal CMS2_k127_3071548_22 1249480.B649_06170 1.146e-47 182.0 COG3850@1|root,COG3850@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity - - 2.7.13.3,4.6.1.1 ko:K01768,ko:K07673,ko:K07713 ko00230,ko02020,ko02025,ko04113,ko04213,map00230,map02020,map02025,map04113,map04213 M00471,M00499,M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3365,Guanylate_cyc,HAMP,HATPase_c,MCPsignal,PilJ,dCache_1,dCache_3 CMS2_k127_3071548_18 1249480.B649_06165 3.155e-67 235.0 COG0664@1|root,COG0664@2|Bacteria,1RIIE@1224|Proteobacteria,42T56@68525|delta/epsilon subdivisions,2YPFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K - catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding CMS2_k127_3071548_19 1172190.M947_06800 1.118e-60 211.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,42TMU@68525|delta/epsilon subdivisions,2YPEI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 CMS2_k127_3071548_29 306263.Cla_0993 5.334e-08 55.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2YM7K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT CMS2_k127_3091996_12 202952.BBLI01000004_gene491 5.076e-06 51.0 2DR59@1|root,33A7S@2|Bacteria,1NMH2@1224|Proteobacteria,1SIVW@1236|Gammaproteobacteria,3NS87@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3091996_3 929558.SMGD1_1348 3.096e-110 379.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1Q49C@1224|Proteobacteria,42MW2@68525|delta/epsilon subdivisions,2YNR7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM EAL domain - - - - - - - - - - - - EAL,GGDEF,Response_reg CMS2_k127_3091996_4 929558.SMGD1_1936 3.135e-87 299.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,42P0U@68525|delta/epsilon subdivisions,2YNIG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S AI-2E family transporter - - - ko:K11744 - - - - ko00000 - - - AI-2E_transport CMS2_k127_3091996_2 563040.Saut_1582 1.051e-120 392.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2YMI2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - ko:K02034,ko:K12370 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N CMS2_k127_3091996_0 1249480.B649_03465 3.006e-205 656.0 COG1256@1|root,COG1749@1|root,COG1256@2|Bacteria,COG1749@2|Bacteria,1MV2M@1224|Proteobacteria,42PBN@68525|delta/epsilon subdivisions,2YMGR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C CMS2_k127_3091996_7 1249480.B649_03460 1.82e-48 178.0 2AIM0@1|root,32I9V@2|Bacteria,1Q1S6@1224|Proteobacteria,42U9Z@68525|delta/epsilon subdivisions,2YPXP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3091996_11 326298.Suden_0564 2.302e-09 60.0 2AK6X@1|root,31AX3@2|Bacteria,1Q6DV@1224|Proteobacteria,432YY@68525|delta/epsilon subdivisions,2YSIQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Anti-sigma-28 factor, FlgM - - - - - - - - - - - - FlgM CMS2_k127_3091996_10 563040.Saut_1586 4.645e-25 109.0 COG3951@1|root,COG3951@2|Bacteria,1Q5W9@1224|Proteobacteria,42UQG@68525|delta/epsilon subdivisions,2YPWJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MNO Rod binding protein flgJ - - - - - - - - - - - Rod-binding CMS2_k127_3091996_1 563040.Saut_1587 3.696e-145 467.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,42MAU@68525|delta/epsilon subdivisions,2YMBU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI CMS2_k127_3091996_5 563040.Saut_1588 7.131e-63 221.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2YP4X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L methyltransferase rsmD - - - - - - - - - - - Cons_hypoth95 CMS2_k127_3091996_9 326298.Suden_0560 2.457e-32 129.0 2B10Q@1|root,319PM@2|Bacteria,1Q3G4@1224|Proteobacteria,42X9K@68525|delta/epsilon subdivisions,2YQYY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3091996_6 326298.Suden_0559 4.165e-58 208.0 COG0847@1|root,COG0847@2|Bacteria,1RGGD@1224|Proteobacteria,42ZIP@68525|delta/epsilon subdivisions,2YRQP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0847 DNA polymerase III epsilon subunit and related 3'-5' - - 2.7.7.7 ko:K02342,ko:K10857 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T CMS2_k127_3111549_18 387093.SUN_1325 1.918e-84 284.0 COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,42S7E@68525|delta/epsilon subdivisions,2YP7T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q 2-keto-4-pentenoate hydratase - - - - - - - - - - - - FAA_hydrolase CMS2_k127_3111549_34 686340.Metal_3856 9.21e-32 124.0 COG0053@1|root,COG0053@2|Bacteria,1N8A3@1224|Proteobacteria,1SDJW@1236|Gammaproteobacteria,1XFQ9@135618|Methylococcales 135618|Methylococcales P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - - CMS2_k127_3111549_14 1165841.SULAR_09619 5.063e-114 371.0 COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,42TT9@68525|delta/epsilon subdivisions 1224|Proteobacteria O methyltransferase - - - - - - - - - - - - ICMT,PEMT CMS2_k127_3111549_20 1127673.GLIP_4306 2.939e-76 265.0 COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,4666X@72275|Alteromonadaceae 1236|Gammaproteobacteria T HPP family - - - ko:K07168 - - - - ko00000 - - - HPP CMS2_k127_3111549_0 1165841.SULAR_03862 3.388e-308 951.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,42YPF@68525|delta/epsilon subdivisions,2YRMB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterized ACR, YdiU/UPF0061 family - - - - - - - - - - - - UPF0061 CMS2_k127_3111549_38 387092.NIS_0966 8.814e-27 116.0 COG0680@1|root,COG0680@2|Bacteria,1N3AS@1224|Proteobacteria,43AZK@68525|delta/epsilon subdivisions,2YP7W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Hydrogenase maturation protease - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI CMS2_k127_3111549_13 1172190.M947_01020 3.411e-121 393.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2YN5P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA CMS2_k127_3111549_43 1541065.JRFE01000014_gene1306 1.942e-14 81.0 2CCI4@1|root,30BPJ@2|Bacteria,1GAR7@1117|Cyanobacteria,3VMXW@52604|Pleurocapsales 1117|Cyanobacteria - - - - - - - - - - - - - - - CMS2_k127_3111549_37 1165841.SULAR_01165 5.975e-27 116.0 COG4886@1|root,COG4886@2|Bacteria,1R9FD@1224|Proteobacteria,42XXN@68525|delta/epsilon subdivisions,2YQP2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Leucine Rich repeats (2 copies) - - - - - - - - - - - - LRR_4 CMS2_k127_3111549_35 613026.HRAG_01562 4.487e-31 128.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42RJW@68525|delta/epsilon subdivisions,2YP85@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI CMS2_k127_3111549_11 944547.ABLL_0160 3.45e-122 406.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,42PV5@68525|delta/epsilon subdivisions,2YMVK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Mate efflux family protein - - - - - - - - - - - - MatE CMS2_k127_3111549_31 273063.STK_10070 8.689e-37 147.0 COG0819@1|root,arCOG01128@2157|Archaea,2XQTN@28889|Crenarchaeota 28889|Crenarchaeota K TENA/THI-4/PQQC family - - 3.5.99.2 ko:K03707 ko00730,ko01100,map00730,map01100 - R02133,R09993 RC00224,RC00652,RC02832 ko00000,ko00001,ko01000,ko03000 - - - TENA_THI-4 CMS2_k127_3111549_15 313594.PI23P_08135 2.271e-104 346.0 COG0351@1|root,COG0351@2|Bacteria,4NE0F@976|Bacteroidetes,1I09C@117743|Flavobacteriia,3VX71@52959|Polaribacter 976|Bacteroidetes H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin CMS2_k127_3111549_6 393595.ABO_0256 2.255e-165 530.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1XH5T@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS2_k127_3111549_29 929558.SMGD1_0181 1.204e-38 147.0 COG2346@1|root,COG2346@2|Bacteria,1MZSM@1224|Proteobacteria,42S0I@68525|delta/epsilon subdivisions,2YPBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG2346, Truncated hemoglobins ctb - - ko:K06886 - - - - ko00000 - - - Bac_globin CMS2_k127_3111549_3 929558.SMGD1_0918 5.893e-214 673.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,42NTK@68525|delta/epsilon subdivisions,2YNFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 CMS2_k127_3111549_44 1348114.OM33_21810 5.357e-10 67.0 COG1670@1|root,COG1670@2|Bacteria,1N8Q6@1224|Proteobacteria,1SDH9@1236|Gammaproteobacteria,2Q3GC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - - - - - - - - - - - Acetyltransf_3 CMS2_k127_3111549_26 573569.F7308_0074 7.649e-51 190.0 COG1984@1|root,COG1984@2|Bacteria,1MU9H@1224|Proteobacteria,1RR39@1236|Gammaproteobacteria,460QX@72273|Thiotrichales 72273|Thiotrichales E Carboxyltransferase domain, subdomain A and B - - - - - - - - - - - - CT_A_B CMS2_k127_3111549_25 1547445.LO80_06595 3.367e-58 209.0 COG1540@1|root,COG1540@2|Bacteria,1MUYV@1224|Proteobacteria,1RSCZ@1236|Gammaproteobacteria,460R2@72273|Thiotrichales 72273|Thiotrichales S Belongs to the UPF0271 (lamB) family - - - ko:K07160 - - - - ko00000 - - - LamB_YcsF CMS2_k127_3111549_28 1547445.LO80_06590 4.862e-39 153.0 COG2049@1|root,COG2049@2|Bacteria,1MWRB@1224|Proteobacteria,1RQIQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Allophanate hydrolase, subunit 1 ybgJ - - - - - - - - - - - CT_C_D CMS2_k127_3111549_42 929558.SMGD1_1479 7.747e-15 80.0 COG2703@1|root,COG2703@2|Bacteria,1N9YV@1224|Proteobacteria,42V6I@68525|delta/epsilon subdivisions,2YQMA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P oxygen carrier activity - - - ko:K07216 - - - - ko00000 - - - Hemerythrin CMS2_k127_3111549_12 1165841.SULAR_09479 1.787e-121 396.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,42RGS@68525|delta/epsilon subdivisions,2YNY5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N CMS2_k127_3111549_40 273121.WS2205 7.453e-19 89.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2YMXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins - - - ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N CMS2_k127_3111549_1 1165841.SULAR_00015 6.472e-245 762.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,42NTK@68525|delta/epsilon subdivisions,2YNFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 CMS2_k127_3111549_39 207954.MED92_11109 4.104e-22 102.0 COG2703@1|root,COG2703@2|Bacteria,1N3PI@1224|Proteobacteria,1SB9K@1236|Gammaproteobacteria,1XKI5@135619|Oceanospirillales 135619|Oceanospirillales P oxygen carrier activity - - - ko:K07216 - - - - ko00000 - - - Hemerythrin CMS2_k127_3111549_2 1165841.SULAR_09844 2.185e-230 719.0 COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,42PMA@68525|delta/epsilon subdivisions,2YR9X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Major facilitator superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 CMS2_k127_3111549_46 563040.Saut_0081 7.211e-05 49.0 2AMA7@1|root,31C55@2|Bacteria,1QGIU@1224|Proteobacteria,432YR@68525|delta/epsilon subdivisions,2YSPH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3111549_30 1172190.M947_08985 2.046e-38 144.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2YPX8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Cold-shock protein cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS2_k127_3111549_22 326298.Suden_0735 7.095e-71 260.0 COG5001@1|root,COG5001@2|Bacteria 2|Bacteria T cyclic-guanylate-specific phosphodiesterase activity - - - - - - - - - - - - EAL,FIST,FIST_C,GGDEF,NIT,PAS_3,PAS_9,Response_reg CMS2_k127_3111549_17 653733.Selin_2418 3.653e-94 332.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria 2|Bacteria T GGDEF domain yliE GO:0003674,GO:0003824,GO:0008081,GO:0016787,GO:0016788,GO:0042578,GO:0071111 - - - - - - - - - - CHASE9,EAL,GGDEF,Response_reg CMS2_k127_3111549_16 326298.Suden_1235 6.156e-97 321.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2YMFJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N CMS2_k127_3111549_10 1172190.M947_01475 9.658e-139 449.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2YM9A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 CMS2_k127_3111549_19 1249480.B649_07495 1.559e-80 271.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2YNX7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iIT341.HP1016 CDP-OH_P_transf CMS2_k127_3111549_9 563040.Saut_0922 5.286e-147 467.0 COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,42KZK@68525|delta/epsilon subdivisions,2YMUM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ dehydrogenase hdhA - 1.1.1.159 ko:K00076 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - adh_short_C2 CMS2_k127_3111549_7 563040.Saut_0923 2.244e-164 521.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2YN2X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS CMS2_k127_3111549_5 709032.Sulku_0933 4.386e-195 616.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2YMMP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the peptidase M16 family pqqL - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_3111549_8 929558.SMGD1_2515 6.353e-164 521.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2YMYR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD - 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh CMS2_k127_3111549_4 929558.SMGD1_2520 2.221e-201 636.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2YMAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g CMS2_k127_3111549_23 1172190.M947_01105 1.189e-70 245.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2YMFV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN CMS2_k127_3116200_31 1172190.M947_01785 3.853e-66 232.0 COG0546@1|root,COG0546@2|Bacteria,1NDKE@1224|Proteobacteria,42SW4@68525|delta/epsilon subdivisions,2YPI4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S HAD-superfamily hydrolase, subfamily IA, variant 1 - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 CMS2_k127_3116200_18 929558.SMGD1_0006 1.793e-133 432.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2YM8W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase CMS2_k127_3116200_38 929558.SMGD1_2856 2.232e-40 160.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2YPWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S alpha beta - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 CMS2_k127_3116200_25 1537917.JU82_01275 6.906e-96 327.0 COG0665@1|root,COG0665@2|Bacteria,1Q0BQ@1224|Proteobacteria,42RXA@68525|delta/epsilon subdivisions,2YP66@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E COGs COG0665 Glycine D-amino acid oxidase (deaminating) - - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO CMS2_k127_3116200_7 387093.SUN_1701 2.358e-244 771.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2YMN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA_synt_2f CMS2_k127_3116200_28 387093.SUN_1204 3.281e-75 253.0 COG2033@1|root,COG2033@2|Bacteria,1NDWH@1224|Proteobacteria,42RSM@68525|delta/epsilon subdivisions,2YP5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Desulfoferrodoxin ferrous iron-binding - - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrodox CMS2_k127_3116200_30 929558.SMGD1_2867 3.521e-68 239.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2YNXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG CMS2_k127_3116200_22 929558.SMGD1_2868 2.753e-115 385.0 COG0683@1|root,COG0683@2|Bacteria,1Q7JN@1224|Proteobacteria,42NDA@68525|delta/epsilon subdivisions,2YN6T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E leucine binding - - - - - - - - - - - - - CMS2_k127_3116200_39 1537915.JU57_12550 1.304e-35 139.0 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,42U5E@68525|delta/epsilon subdivisions,2YPTW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S thioesterase ybgC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT CMS2_k127_3116200_44 1239962.C943_04408 0.0009356 49.0 COG0457@1|root,COG4585@1|root,COG0457@2|Bacteria,COG4585@2|Bacteria,4NI1V@976|Bacteroidetes,47Q3Z@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,TPR_10,TPR_12,TPR_8 CMS2_k127_3116200_15 1165841.SULAR_03737 2.051e-158 504.0 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,42QTP@68525|delta/epsilon subdivisions,2YPVD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase CMS2_k127_3116200_0 1165841.SULAR_03742 0.0 1454.0 COG3387@1|root,COG3387@2|Bacteria,1MXWR@1224|Proteobacteria 1224|Proteobacteria G phosphorylase kinase alphabeta ygeQ - - ko:K07190 ko04020,ko04910,ko04922,map04020,map04910,map04922 - - - ko00000,ko00001 - - - Glyco_hydro_15 CMS2_k127_3116200_10 709032.Sulku_1274 5.001e-198 623.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2YMDF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK CMS2_k127_3116200_5 1249480.B649_05400 6.881e-313 962.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2YMGS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase CMS2_k127_3116200_14 709032.Sulku_1271 7.482e-159 511.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2YMKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI CMS2_k127_3116200_8 484770.UFO1_0374 1.518e-239 751.0 COG0033@1|root,COG0033@2|Bacteria,1UKP8@1239|Firmicutes,4H3T3@909932|Negativicutes 909932|Negativicutes G Phosphoglucomutase - - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS2_k127_3116200_2 1165841.SULAR_03752 0.0 1221.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2YNMV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 CMS2_k127_3116200_6 1165841.SULAR_03757 1.182e-280 867.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2YNK4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 CMS2_k127_3116200_11 1165841.SULAR_03762 6.139e-194 615.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2YR9K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Synthesizes alpha-1,4-glucan chains using ADP-glucose - - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 CMS2_k127_3116200_33 1121468.AUBR01000034_gene1372 3.855e-62 227.0 COG1085@1|root,COG1085@2|Bacteria,1TS3F@1239|Firmicutes,249P3@186801|Clostridia,42F43@68295|Thermoanaerobacterales 186801|Clostridia H PFAM Galactose-1-phosphate uridyl transferase galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - DUF4921,DUF4931,GalP_UDP_tr_C,GalP_UDP_transf CMS2_k127_3116200_3 1165841.SULAR_03772 0.0 1158.0 COG1449@1|root,COG1449@2|Bacteria,1Q9WP@1224|Proteobacteria,42M42@68525|delta/epsilon subdivisions,2YMAK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glycosyl hydrolase 57 family - - 2.4.1.25 ko:K22451 ko00500,map00500 - R05196 RC00049 ko00000,ko00001,ko01000 - GH57 - DUF1925,DUF1926,Glyco_hydro_57 CMS2_k127_3116200_4 1165841.SULAR_03777 0.0 1142.0 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,42N8E@68525|delta/epsilon subdivisions,2YNF0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 CMS2_k127_3116200_1 1165841.SULAR_03782 0.0 1396.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2YMSQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II CMS2_k127_3116200_36 1165841.SULAR_03787 1.436e-42 157.0 29Y6B@1|root,30JZQ@2|Bacteria,1R1Q3@1224|Proteobacteria,43DAV@68525|delta/epsilon subdivisions,2YR17@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - AMPK1_CBM CMS2_k127_3116200_23 749222.Nitsa_0853 2.253e-110 364.0 COG0847@1|root,COG0847@2|Bacteria,1PQ1V@1224|Proteobacteria,42PMC@68525|delta/epsilon subdivisions,2YNJA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L dna polymerase iii - - - ko:K10857 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - RNase_T CMS2_k127_3116200_42 8081.XP_008407648.1 0.0002211 53.0 KOG4643@1|root,KOG4643@2759|Eukaryota,38CBD@33154|Opisthokonta,3BBRW@33208|Metazoa,3CZG6@33213|Bilateria,48HH6@7711|Chordata,49EIZ@7742|Vertebrata 33208|Metazoa S Coiled-coil domain containing 88Aa CCDC88A GO:0000226,GO:0000902,GO:0000904,GO:0001932,GO:0001934,GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0005912,GO:0005913,GO:0005914,GO:0005915,GO:0005929,GO:0006275,GO:0006810,GO:0006928,GO:0006996,GO:0007010,GO:0007015,GO:0007017,GO:0007154,GO:0007155,GO:0007165,GO:0007275,GO:0007399,GO:0008017,GO:0008092,GO:0008150,GO:0008289,GO:0008361,GO:0009653,GO:0009889,GO:0009893,GO:0009987,GO:0010556,GO:0010562,GO:0010604,GO:0010638,GO:0010975,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016358,GO:0016477,GO:0019219,GO:0019220,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022008,GO:0022607,GO:0022610,GO:0023052,GO:0030027,GO:0030029,GO:0030030,GO:0030031,GO:0030032,GO:0030036,GO:0030054,GO:0030154,GO:0030182,GO:0030425,GO:0030705,GO:0031122,GO:0031175,GO:0031252,GO:0031323,GO:0031325,GO:0031326,GO:0031344,GO:0031346,GO:0031399,GO:0031401,GO:0031410,GO:0031929,GO:0031982,GO:0032147,GO:0032148,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032535,GO:0032879,GO:0032880,GO:0032956,GO:0032970,GO:0032989,GO:0032990,GO:0033043,GO:0033674,GO:0035091,GO:0035556,GO:0036064,GO:0036477,GO:0040011,GO:0042127,GO:0042325,GO:0042327,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043085,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043296,GO:0043422,GO:0043549,GO:0044085,GO:0044087,GO:0044089,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044450,GO:0044463,GO:0044464,GO:0045595,GO:0045664,GO:0045724,GO:0045793,GO:0045859,GO:0045860,GO:0045937,GO:0046907,GO:0046983,GO:0048468,GO:0048518,GO:0048522,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048813,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050767,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051052,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051239,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0051493,GO:0051641,GO:0051649,GO:0051674,GO:0051716,GO:0051959,GO:0051960,GO:0060255,GO:0060284,GO:0060341,GO:0060491,GO:0061024,GO:0065007,GO:0065008,GO:0065009,GO:0070161,GO:0071683,GO:0071840,GO:0071944,GO:0080090,GO:0090066,GO:0090130,GO:0090132,GO:0090136,GO:0097435,GO:0097447,GO:0097458,GO:0097581,GO:0097708,GO:0098609,GO:0120025,GO:0120031,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:1902017,GO:1902115,GO:1902117,GO:1903564,GO:1903566,GO:1903827,GO:1903829,GO:2000026,GO:2000112 - - - - - - - - - - HOOK CMS2_k127_3116200_13 709032.Sulku_1226 8.474e-161 512.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2YMUA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 CMS2_k127_3116200_16 387093.SUN_0283 5.134e-144 461.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42R8Z@68525|delta/epsilon subdivisions,2YMR6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin CMS2_k127_3116200_17 929558.SMGD1_1853 3.03e-139 444.0 2AI6H@1|root,318KU@2|Bacteria,1Q0KF@1224|Proteobacteria,42S88@68525|delta/epsilon subdivisions,2YP9S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3116200_34 1249480.B649_04020 1.2e-57 227.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YM8N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - DUF3365,EAL,GGDEF,dCache_3 CMS2_k127_3116200_29 944547.ABLL_1633 6.385e-74 277.0 COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42R1U@68525|delta/epsilon subdivisions,2YNX6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PAS domain - - - - - - - - - - - - HATPase_c,PAS_9 CMS2_k127_3116200_21 1355368.JART01000002_gene2274 1.828e-119 393.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QAG@68525|delta/epsilon subdivisions,2YNQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg CMS2_k127_3116200_24 709032.Sulku_1511 3.054e-108 392.0 COG2199@1|root,COG2200@1|root,COG3287@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG3287@2|Bacteria,1NQKX@1224|Proteobacteria,43DAG@68525|delta/epsilon subdivisions,2YTHK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T FIST N domain - - - - - - - - - - - - EAL,FIST,FIST_C,GGDEF,PAS_9 CMS2_k127_3116200_32 929558.SMGD1_0374 3.855e-64 237.0 COG3437@1|root,COG3437@2|Bacteria,1QYD6@1224|Proteobacteria,43CBH@68525|delta/epsilon subdivisions,2YTB6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T cheY-homologous receiver domain - - 3.1.1.61,3.5.1.44 ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - Response_reg CMS2_k127_3116200_40 929558.SMGD1_0228 7.647e-34 143.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,HTH_18,Response_reg CMS2_k127_3116200_37 929558.SMGD1_2475 1.251e-41 155.0 COG0011@1|root,COG0011@2|Bacteria,1N2GU@1224|Proteobacteria,42UPF@68525|delta/epsilon subdivisions,2YQEK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP CMS2_k127_3116200_43 563040.Saut_1383 0.0002418 49.0 2BME9@1|root,32FYS@2|Bacteria,1Q6HK@1224|Proteobacteria,4335F@68525|delta/epsilon subdivisions,2YSJQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3116200_26 929558.SMGD1_2552 1.541e-85 284.0 COG0537@1|root,COG0537@2|Bacteria,1RHYQ@1224|Proteobacteria,42SEG@68525|delta/epsilon subdivisions,2YNWN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FG HIT family - - - - - - - - - - - - HIT CMS2_k127_3116200_12 563040.Saut_0946 1.134e-182 580.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,42MQU@68525|delta/epsilon subdivisions,2YMC7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q TRAP transporter, DctM subunit - - - - - - - - - - - - DctM,DctQ CMS2_k127_3116200_35 326298.Suden_1205 2.802e-52 188.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,42SCS@68525|delta/epsilon subdivisions,2YPIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Tripartite ATP-independent periplasmic transporter DctQ component - - - - - - - - - - - - DctQ CMS2_k127_3116200_9 1172190.M947_01080 1.903e-199 632.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2YMJ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mur ligase middle domain murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M CMS2_k127_3116200_27 326298.Suden_1207 3.762e-82 279.0 COG0596@1|root,COG0596@2|Bacteria,1NH3R@1224|Proteobacteria,42R8Q@68525|delta/epsilon subdivisions,2YNWT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 CMS2_k127_3116200_19 929558.SMGD1_2547 1.038e-128 420.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2YMGD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N CMS2_k127_3136000_9 1537917.JU82_03765 2.932e-63 221.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,42SJW@68525|delta/epsilon subdivisions,2YNXS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J sigma 54 modulation protein ribosomal protein S30EA raiA - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE CMS2_k127_3136000_0 1172190.M947_06610 3.595e-216 686.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2YMBT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L ATP-dependent DNA helicase recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII CMS2_k127_3136000_2 563040.Saut_0375 2.251e-150 486.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2YMI1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Peptidase, M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C CMS2_k127_3136000_1 1537917.JU82_03750 3.425e-192 603.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,42M6U@68525|delta/epsilon subdivisions,2YN4H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - 1.21.98.1 ko:K11784 ko00130,ko01110,map00130,map01110 - R08588 RC02329 ko00000,ko00001,ko01000 - - - Radical_SAM CMS2_k127_3136000_8 1537917.JU82_03745 9.921e-68 232.0 COG0781@1|root,COG0781@2|Bacteria,1N94P@1224|Proteobacteria,42SEA@68525|delta/epsilon subdivisions,2YPFW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB CMS2_k127_3136000_6 387093.SUN_1919 3.66e-76 257.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2YNVK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase CMS2_k127_3136000_3 563040.Saut_0370 5.017e-131 421.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2YM9D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 CMS2_k127_3136000_4 929558.SMGD1_0828 9.801e-117 385.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,42ME7@68525|delta/epsilon subdivisions,2YMBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG membrane - - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA CMS2_k127_3136000_7 563040.Saut_0366 4.354e-72 251.0 COG1076@1|root,COG1076@2|Bacteria,1N8QM@1224|Proteobacteria,43B25@68525|delta/epsilon subdivisions,2YT59@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O DnaJ domain protein - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB CMS2_k127_3136000_5 326298.Suden_0341 4.533e-100 335.0 COG0679@1|root,COG0679@2|Bacteria,1N5NC@1224|Proteobacteria,42PYE@68525|delta/epsilon subdivisions,2YMUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans CMS2_k127_3136000_10 387093.SUN_1505 2.377e-57 204.0 COG2236@1|root,COG2236@2|Bacteria,1Q1HY@1224|Proteobacteria,42TR4@68525|delta/epsilon subdivisions,2YP9B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F phosphoribosyltransferase gpt - 2.4.2.22 ko:K00769 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01229,R02142 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran CMS2_k127_3151618_3 929558.SMGD1_1084 1.639e-14 74.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2YMCW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iIT341.HP0476 tRNA-synt_1c CMS2_k127_3151618_2 944547.ABLL_0099 2.16e-24 114.0 COG0760@1|root,COG0760@2|Bacteria,1N20M@1224|Proteobacteria,42SXW@68525|delta/epsilon subdivisions,2YPHS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - - - - - - - - - - Rotamase_2,SurA_N,SurA_N_3 CMS2_k127_3151618_0 1537917.JU82_02450 8.77e-250 775.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2YMWB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS2_k127_3151618_1 1537917.JU82_02445 2.301e-47 174.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,42SQQ@68525|delta/epsilon subdivisions,2YPM8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl CMS2_k127_3158152_1 1537915.JU57_12525 9.34e-06 48.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YNBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like CMS2_k127_3158152_0 709032.Sulku_1510 3.453e-270 835.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,42MHB@68525|delta/epsilon subdivisions,2YNUZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase cofactor biosynthesis protein NifB - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM CMS2_k127_3184851_0 709032.Sulku_1860 0.0 1380.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2YMD8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin por - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C CMS2_k127_3184851_3 1123326.JFBL01000004_gene2147 1.702e-35 146.0 2ENEN@1|root,33G25@2|Bacteria,1NIJM@1224|Proteobacteria,42U7Y@68525|delta/epsilon subdivisions,2YPT3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 CMS2_k127_3184851_6 1399774.JDWH01000007_gene1591 4.19e-06 49.0 2EFWG@1|root,339NR@2|Bacteria,1NIWH@1224|Proteobacteria,1SHRN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3184851_2 1198232.CYCME_0289 1.147e-80 278.0 COG1793@1|root,COG1793@2|Bacteria,1MUW3@1224|Proteobacteria,1S2JP@1236|Gammaproteobacteria,460RX@72273|Thiotrichales 72273|Thiotrichales L ATP dependent DNA ligase domain - - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M,DNA_ligase_OB_2 CMS2_k127_3184851_4 1244531.CIG1485E_0170 3.401e-16 80.0 COG1555@1|root,COG1555@2|Bacteria,1PU4P@1224|Proteobacteria,42VEG@68525|delta/epsilon subdivisions,2YQIA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L competence protein comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 CMS2_k127_3184851_1 326298.Suden_0357 0.0 1251.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2YMB2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 CMS2_k127_3184851_5 1172190.M947_07025 3.475e-16 78.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,42QR7@68525|delta/epsilon subdivisions,2YNZC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 CMS2_k127_3185033_13 1537917.JU82_09810 8.063e-29 117.0 COG2944@1|root,COG2944@2|Bacteria,1Q2M2@1224|Proteobacteria,42VXE@68525|delta/epsilon subdivisions,2YQ6V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-binding protein - - - - - - - - - - - - HTH_3 CMS2_k127_3185033_11 1172190.M947_03680 1.158e-44 163.0 COG0776@1|root,COG0776@2|Bacteria,1QQYR@1224|Proteobacteria,42V36@68525|delta/epsilon subdivisions,2YQA9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the bacterial histone-like protein family hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS2_k127_3185033_15 709032.Sulku_0613 5.256e-13 81.0 2AJ4C@1|root,319NV@2|Bacteria,1Q3D8@1224|Proteobacteria,431S6@68525|delta/epsilon subdivisions,2YS5U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3185033_8 1165841.SULAR_00235 8.565e-70 241.0 COG0652@1|root,COG0652@2|Bacteria,1RENS@1224|Proteobacteria,42RIB@68525|delta/epsilon subdivisions,2YPAC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Pro_isomerase CMS2_k127_3185033_1 387093.SUN_1121 2.834e-196 626.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42MYT@68525|delta/epsilon subdivisions,2YMKP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 CMS2_k127_3185033_12 326298.Suden_1503 4.58e-41 157.0 2BYUV@1|root,307Y4@2|Bacteria,1NADG@1224|Proteobacteria,42T6E@68525|delta/epsilon subdivisions,2YPDY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3185033_3 1172190.M947_03500 1.362e-144 467.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2YMDM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H dihydropteroate synthase folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind CMS2_k127_3185033_10 1249480.B649_03025 1.52e-49 183.0 COG0470@1|root,COG0470@2|Bacteria,1R9U1@1224|Proteobacteria,42R45@68525|delta/epsilon subdivisions,2YPZZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 CMS2_k127_3185033_7 1537917.JU82_09870 6.529e-78 264.0 2BM55@1|root,32FNN@2|Bacteria,1Q0P6@1224|Proteobacteria,42SB7@68525|delta/epsilon subdivisions,2YPGR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DNA replication regulator hobA - - - - - - - - - - - HobA CMS2_k127_3185033_0 1249480.B649_03015 6.487e-197 620.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2YMIS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 CMS2_k127_3185033_9 709032.Sulku_0601 1.437e-66 229.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,42RGH@68525|delta/epsilon subdivisions,2YP5E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX CMS2_k127_3185033_4 326298.Suden_1654 1.337e-135 440.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2YMCD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN2 - - - - - - - - - - - Radical_SAM CMS2_k127_3185033_14 1172190.M947_03470 8.467e-28 118.0 COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VD0@68525|delta/epsilon subdivisions,2YQ93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 CMS2_k127_3185033_5 1172190.M947_03465 8.114e-111 363.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2YM87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC CMS2_k127_3185033_2 1537917.JU82_09900 3.12e-145 467.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,42MMG@68525|delta/epsilon subdivisions,2YMCT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth CMS2_k127_3185033_6 1123326.JFBL01000013_gene317 1.223e-97 334.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,42MIH@68525|delta/epsilon subdivisions,2YRAS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HDOD domain - - - - - - - - - - - - EAL,HDOD CMS2_k127_3185033_16 1367491.BN865_14690c 5.466e-06 49.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2YMIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LU DNA processing protein dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A CMS2_k127_3185254_2 326298.Suden_0642 9.069e-57 199.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,42SJJ@68525|delta/epsilon subdivisions,2YPEW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the P(II) protein family glnB - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II CMS2_k127_3185254_0 929558.SMGD1_2139 7.43e-192 604.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2YNUK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp CMS2_k127_3185254_1 1165841.SULAR_06618 2.962e-59 211.0 COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2YP2C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator nssR - - - - - - - - - - - HTH_Crp_2,cNMP_binding CMS2_k127_3185254_3 1165841.SULAR_06603 4.814e-52 187.0 COG1017@1|root,COG1017@2|Bacteria,1QUQ4@1224|Proteobacteria,42R0F@68525|delta/epsilon subdivisions,2YP24@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the globin family cgb - 1.14.12.17 ko:K05916 ko05132,map05132 - - - ko00000,ko00001,ko01000 - - - Globin CMS2_k127_3185254_4 1172190.M947_05185 4.565e-11 68.0 COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,42RSQ@68525|delta/epsilon subdivisions,2YRW7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HPP family - - - - - - - - - - - - HPP CMS2_k127_3213067_0 1150621.SMUL_1003 0.0 1281.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,42P26@68525|delta/epsilon subdivisions,2YN89@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core CMS2_k127_3213067_1 1537915.JU57_05190 0.0 1078.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,42NB9@68525|delta/epsilon subdivisions,2YNN4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 CMS2_k127_3213067_7 1150621.SMUL_1005 3.475e-121 396.0 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,42PJK@68525|delta/epsilon subdivisions,2YNSY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,Transglut_core CMS2_k127_3213067_12 944547.ABLL_2824 1.834e-57 207.0 COG2307@1|root,COG2307@2|Bacteria,1NMSC@1224|Proteobacteria,42V9T@68525|delta/epsilon subdivisions,2YQAK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E CMS2_k127_3213067_4 944547.ABLL_2825 6.626e-238 741.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2YNA8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 CMS2_k127_3213067_10 572480.Arnit_0044 3.008e-93 312.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42QWE@68525|delta/epsilon subdivisions,2YNG3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 CMS2_k127_3213067_8 929558.SMGD1_0693 5.977e-114 374.0 COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,42ND0@68525|delta/epsilon subdivisions,2YP8U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF808) - - - ko:K09781 - - - - ko00000 - - - DUF808 CMS2_k127_3213067_11 572480.Arnit_0209 5.686e-82 280.0 COG3769@1|root,COG3769@2|Bacteria,1NFV5@1224|Proteobacteria,42SQA@68525|delta/epsilon subdivisions 1224|Proteobacteria S HAD-superfamily hydrolase, subfamily IIB yedP - 2.7.1.31,3.1.3.70 ko:K07026,ko:K15918 ko00051,ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00051,map00260,map00561,map00630,map01100,map01110,map01130,map01200 M00532 R01514,R05790 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Hydrolase_3,S6PP CMS2_k127_3213067_9 123214.PERMA_1579 3.685e-104 353.0 COG2379@1|root,COG2379@2|Bacteria 2|Bacteria G hydroxypyruvate reductase ttuD - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL CMS2_k127_3213067_5 572480.Arnit_0211 5.912e-222 692.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,42PX0@68525|delta/epsilon subdivisions 1224|Proteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis gpgS - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - CMS2_k127_3213067_2 572480.Arnit_0212 1.337e-305 943.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,42P6Z@68525|delta/epsilon subdivisions 1224|Proteobacteria G PFAM Alpha amylase, catalytic ycjM - 2.4.1.7 ko:K00690 ko00500,map00500 - R00803 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C CMS2_k127_3213067_6 572480.Arnit_0213 2.769e-160 507.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,42MJU@68525|delta/epsilon subdivisions,2YM7H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M UTP-glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0646 NTP_transferase CMS2_k127_3213067_3 1165841.SULAR_03732 1.368e-266 826.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2YNAU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - iIT341.HP1101 G6PD_C,G6PD_N CMS2_k127_3216204_4 326298.Suden_2090 7.12e-88 296.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2YNGY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD CMS2_k127_3216204_0 326298.Suden_2089 4.017e-311 966.0 COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2YMJN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,RMMBL CMS2_k127_3216204_2 929558.SMGD1_1182 1.667e-145 501.0 COG3164@1|root,COG3164@2|Bacteria,1QUYX@1224|Proteobacteria,43CES@68525|delta/epsilon subdivisions,2YTC9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 CMS2_k127_3216204_1 563040.Saut_0198 9.428e-147 470.0 COG0794@1|root,COG2905@1|root,COG0794@2|Bacteria,COG2905@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2YMCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kpsF - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS CMS2_k127_3216204_3 709032.Sulku_0139 1.051e-109 363.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2YMH9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 CMS2_k127_3216204_7 709032.Sulku_0140 1.75e-45 168.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,42TJK@68525|delta/epsilon subdivisions,2YQ4A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 CMS2_k127_3216204_5 709032.Sulku_0141 7.977e-82 277.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2YMQ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N CMS2_k127_3221433_2 929558.SMGD1_0640 1.409e-09 60.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,42M6B@68525|delta/epsilon subdivisions,2YN3C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF CMS2_k127_3221433_1 1537917.JU82_11860 6.336e-46 171.0 2BTJ1@1|root,32NRK@2|Bacteria,1Q3XC@1224|Proteobacteria,42RS4@68525|delta/epsilon subdivisions,2YPVI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Lipopolysaccharide-assembly - - - - - - - - - - - - LptE CMS2_k127_3221433_0 1249480.B649_02590 1.543e-135 435.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2YMJY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1g CMS2_k127_3225593_7 326298.Suden_1833 2.442e-66 228.0 COG0464@1|root,COG0464@2|Bacteria,1N4ZI@1224|Proteobacteria,42NGJ@68525|delta/epsilon subdivisions,2YMAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATPase (AAA - - - - - - - - - - - - AAA CMS2_k127_3225593_5 563040.Saut_1834 8.721e-101 329.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2YMUT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 CMS2_k127_3225593_4 1537917.JU82_10885 3.263e-121 394.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2YN6R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa CMS2_k127_3225593_3 1537917.JU82_10890 1.457e-248 769.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2YMSC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa CMS2_k127_3225593_8 709032.Sulku_0268 8.641e-33 127.0 2AITQ@1|root,319AS@2|Bacteria,1Q26T@1224|Proteobacteria,42V2V@68525|delta/epsilon subdivisions,2YQFN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S putative NADH-ubiquinone oxidoreductase chain E nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADH-UOR_E CMS2_k127_3225593_1 929558.SMGD1_1685 0.0 1159.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2YM9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase - - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 CMS2_k127_3225593_2 709032.Sulku_0270 2.754e-318 989.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4_10,Molybdopterin,NADH-G_4Fe-4S_3 CMS2_k127_3225593_0 563040.Saut_1828 0.0 1259.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 CMS2_k127_3225593_6 1172190.M947_04175 2.583e-91 302.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2YMNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh CMS2_k127_3248387_9 1123326.JFBL01000001_gene1419 3.174e-48 174.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2YMUE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB CMS2_k127_3248387_0 768671.ThimaDRAFT_1090 1e-323 1017.0 COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria,1T2RH@1236|Gammaproteobacteria,1WW59@135613|Chromatiales 1236|Gammaproteobacteria NT PFAM CheB methylesterase - - - - - - - - - - - - CheB_methylest,CheR,CheR_N,PAS,PAS_10,PAS_4 CMS2_k127_3248387_8 944547.ABLL_1633 3.237e-62 230.0 COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42R1U@68525|delta/epsilon subdivisions,2YNX6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PAS domain - - - - - - - - - - - - HATPase_c,PAS_9 CMS2_k127_3248387_3 1165841.SULAR_09224 8.291e-144 459.0 COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,42Q39@68525|delta/epsilon subdivisions,2YTRX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Formate/nitrite transporter - - - ko:K21993 - - - - ko00000,ko02000 1.A.16.2 - - Form_Nir_trans CMS2_k127_3248387_7 1165841.SULAR_09229 4.685e-71 242.0 COG1513@1|root,COG1513@2|Bacteria,1R9X0@1224|Proteobacteria 1224|Proteobacteria P Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide cynS - 4.2.1.104 ko:K01725 ko00910,map00910 - R03546,R10079 RC00952 ko00000,ko00001,ko01000 - - - Cyanate_lyase CMS2_k127_3248387_1 1165841.SULAR_09234 1.254e-273 851.0 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2YNMJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KLT COG0631 Serine threonine protein phosphatase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PP2C_2,Pkinase CMS2_k127_3248387_5 1232410.KI421418_gene2207 6.09e-112 371.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42MI8@68525|delta/epsilon subdivisions,2WJDT@28221|Deltaproteobacteria,43SIZ@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase CMS2_k127_3248387_2 1123393.KB891316_gene1370 2.382e-181 578.0 COG1215@1|root,COG1215@2|Bacteria,1R9CM@1224|Proteobacteria 1224|Proteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 CMS2_k127_3248387_6 1123393.KB891316_gene1371 6.77e-82 306.0 COG0457@1|root,COG0457@2|Bacteria,1RCSG@1224|Proteobacteria 1224|Proteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 CMS2_k127_3248387_4 387092.NIS_0283 4.016e-133 437.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2YMAG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N CMS2_k127_3248387_10 563040.Saut_1746 2.603e-15 78.0 2B2IW@1|root,31V40@2|Bacteria,1QSZI@1224|Proteobacteria,4332K@68525|delta/epsilon subdivisions,2YSGU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3253497_1 563040.Saut_1878 1.239e-288 888.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2YNCK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N CMS2_k127_3253497_11 387093.SUN_0963 7.105e-83 286.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2YREZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GHKL domain - - - - - - - - - - - - HATPase_c CMS2_k127_3253497_15 1565314.OA34_13225 2.499e-39 154.0 COG0745@1|root,COG0745@2|Bacteria,1QZNH@1224|Proteobacteria,42SJZ@68525|delta/epsilon subdivisions,2YPIE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_3253497_9 929558.SMGD1_1585 1.4e-95 325.0 COG0642@1|root,COG0642@2|Bacteria,1RGPU@1224|Proteobacteria,42RPY@68525|delta/epsilon subdivisions,2YPD9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA CMS2_k127_3253497_8 1165841.SULAR_01145 4.951e-98 325.0 COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,42T87@68525|delta/epsilon subdivisions,2YMZ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin CMS2_k127_3253497_16 1165841.SULAR_00975 2.714e-39 147.0 COG2388@1|root,COG2388@2|Bacteria,1NKJW@1224|Proteobacteria 1224|Proteobacteria S -acetyltransferase - - - ko:K06975 - - - - ko00000 - - - Acetyltransf_CG,GFA CMS2_k127_3253497_4 1121121.KB894288_gene2851 5.074e-169 544.0 COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,4H9U7@91061|Bacilli,26SYZ@186822|Paenibacillaceae 91061|Bacilli P NADH oxidase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim CMS2_k127_3253497_2 709032.Sulku_2229 8.955e-288 891.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2YNDA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer CMS2_k127_3253497_7 1202962.KB907172_gene2501 2.692e-101 334.0 COG4380@1|root,COG4380@2|Bacteria,1R3WM@1224|Proteobacteria,1RSP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S (Lipo)protein VY92_06375 - - - - - - - - - - - DUF799 CMS2_k127_3253497_18 1265503.KB905160_gene2614 1.719e-31 126.0 COG4259@1|root,COG4259@2|Bacteria,1N7DV@1224|Proteobacteria,1SC8T@1236|Gammaproteobacteria,2Q84R@267889|Colwelliaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4810) - - - - - - - - - - - - DUF4810 CMS2_k127_3253497_20 1202962.KB907172_gene2503 4.124e-23 101.0 2EP4S@1|root,33GRG@2|Bacteria,1NMBR@1224|Proteobacteria,1SS9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3253497_6 1202962.KB907172_gene2504 2.391e-140 452.0 COG1462@1|root,COG1462@2|Bacteria,1NDU8@1224|Proteobacteria,1RPPY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Curli production assembly transport component CsgG csgG - - - - - - - - - - - CsgG CMS2_k127_3253497_3 929558.SMGD1_1581 1.25e-260 818.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,43BJ8@68525|delta/epsilon subdivisions,2YMMJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M penicillin-binding protein pbpA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase CMS2_k127_3253497_10 563040.Saut_1881 2.02e-92 308.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,42M3F@68525|delta/epsilon subdivisions,2YNXH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EP abc transporter atp-binding protein - - 3.6.3.24 ko:K02031,ko:K15587 ko02010,ko02024,map02010,map02024 M00239,M00440 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.5 - - ABC_tran CMS2_k127_3253497_5 563040.Saut_1882 7.199e-142 458.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2YN3A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E 8-amino-7-oxononanoate synthase bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_3253497_12 563040.Saut_1884 8.409e-75 256.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2YP8T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D nucleotide-binding protein implicated in inhibition of septum formation maf - - ko:K06287 - - - - ko00000 - - - Maf CMS2_k127_3253497_19 1249480.B649_10515 2.7e-30 126.0 COG5615@1|root,COG5615@2|Bacteria,1Q1AZ@1224|Proteobacteria,42T6C@68525|delta/epsilon subdivisions,2YPN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S integral membrane protein - - - - - - - - - - - - - CMS2_k127_3253497_14 563040.Saut_1885 2.53e-61 216.0 COG5615@1|root,COG5615@2|Bacteria,1Q1AZ@1224|Proteobacteria,42T6C@68525|delta/epsilon subdivisions,2YPN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S integral membrane protein - - - - - - - - - - - - - CMS2_k127_3253497_0 1537917.JU82_08485 0.0 1287.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2YMJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS2_k127_3256976_0 1165841.SULAR_09224 1.402e-164 520.0 COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,42Q39@68525|delta/epsilon subdivisions,2YTRX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Formate/nitrite transporter - - - ko:K21993 - - - - ko00000,ko02000 1.A.16.2 - - Form_Nir_trans CMS2_k127_3256976_1 1165841.SULAR_09229 1.081e-87 289.0 COG1513@1|root,COG1513@2|Bacteria,1R9X0@1224|Proteobacteria 1224|Proteobacteria P Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide cynS - 4.2.1.104 ko:K01725 ko00910,map00910 - R03546,R10079 RC00952 ko00000,ko00001,ko01000 - - - Cyanate_lyase CMS2_k127_3260693_3 563040.Saut_2089 2.616e-52 193.0 COG0746@1|root,COG0746@2|Bacteria,1NEIC@1224|Proteobacteria,42SCE@68525|delta/epsilon subdivisions,2YPMS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 CMS2_k127_3260693_6 572480.Arnit_2908 9.097e-28 116.0 29BUT@1|root,2ZYT3@2|Bacteria,1Q552@1224|Proteobacteria,430JR@68525|delta/epsilon subdivisions,2YS3W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3260693_7 1535422.ND16A_1516 0.0001915 51.0 2DN52@1|root,32VJD@2|Bacteria,1N1NP@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3313) - - - - - - - - - - - - DUF3313 CMS2_k127_3260693_1 709032.Sulku_2659 1.146e-69 253.0 COG0790@1|root,COG2829@1|root,COG0790@2|Bacteria,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,42R3P@68525|delta/epsilon subdivisions,2YPBM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COGs COG2829 Outer membrane phospholipase A - - 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - PLA1 CMS2_k127_3260693_2 563040.Saut_1020 8.048e-66 231.0 COG0546@1|root,COG0546@2|Bacteria,1NDKE@1224|Proteobacteria,42SW4@68525|delta/epsilon subdivisions,2YPI4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S HAD-superfamily hydrolase, subfamily IA, variant 1 - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 CMS2_k127_3260693_0 1172190.M947_01790 2.997e-135 437.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2YM8W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase CMS2_k127_3260693_5 929558.SMGD1_2856 4.713e-41 162.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2YPWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S alpha beta - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 CMS2_k127_3260693_4 1537917.JU82_01275 9.647e-51 188.0 COG0665@1|root,COG0665@2|Bacteria,1Q0BQ@1224|Proteobacteria,42RXA@68525|delta/epsilon subdivisions,2YP66@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E COGs COG0665 Glycine D-amino acid oxidase (deaminating) - - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO CMS2_k127_3287087_8 1094715.CM001373_gene2866 0.0001846 44.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1JD9E@118969|Legionellales 118969|Legionellales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF CMS2_k127_3287087_3 929558.SMGD1_0450 1.712e-111 380.0 COG0642@1|root,COG0642@2|Bacteria,1QZ2C@1224|Proteobacteria,42QBR@68525|delta/epsilon subdivisions,2YNQB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,dCache_2,sCache_2 CMS2_k127_3287087_4 929558.SMGD1_0449 1.385e-96 320.0 COG0745@1|root,COG0745@2|Bacteria,1Q5DC@1224|Proteobacteria,42R42@68525|delta/epsilon subdivisions,2YNXG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_3287087_2 929558.SMGD1_0447 2.648e-134 441.0 COG3203@1|root,COG3203@2|Bacteria,1R1K3@1224|Proteobacteria,43DCJ@68525|delta/epsilon subdivisions,2YTI4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M outer membrane porin, OprD family - - - - - - - - - - - - OprD CMS2_k127_3287087_6 709032.Sulku_1833 5.529e-36 139.0 COG3162@1|root,COG3162@2|Bacteria,1MZF3@1224|Proteobacteria,42THN@68525|delta/epsilon subdivisions,2YPTV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane - - - - - - - - - - - - DUF485 CMS2_k127_3287087_0 929558.SMGD1_0445 3.011e-315 970.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2YN7F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF CMS2_k127_3287087_1 1249480.B649_03580 9.426e-233 734.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2YN4X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal-transduction protein containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding CMS2_k127_3287087_5 1537917.JU82_05805 2.671e-87 291.0 COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,42RBT@68525|delta/epsilon subdivisions,2YNWW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L dna polymerase iii dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T CMS2_k127_3287087_7 929558.SMGD1_0442 1.655e-25 108.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2YN92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS2_k127_3289136_8 1249480.B649_11575 2.966e-110 370.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,42NZ4@68525|delta/epsilon subdivisions,2YNNY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I COG2067 Long-chain fatty acid transport protein - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X CMS2_k127_3289136_7 929558.SMGD1_1209 2.003e-113 375.0 COG3439@1|root,COG3439@2|Bacteria,1PWY7@1224|Proteobacteria,42Y9J@68525|delta/epsilon subdivisions,2YRF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - - CMS2_k127_3289136_14 563040.Saut_2129 6.4e-79 273.0 COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,42VE6@68525|delta/epsilon subdivisions,2YRDJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - - CMS2_k127_3289136_12 387093.SUN_0559 1.892e-84 293.0 COG3439@1|root,COG3439@2|Bacteria,1PWY7@1224|Proteobacteria,42Y9J@68525|delta/epsilon subdivisions,2YRF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - - CMS2_k127_3289136_13 563040.Saut_2101 4.172e-81 281.0 COG3439@1|root,COG3439@2|Bacteria 2|Bacteria D Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 CMS2_k127_3289136_16 326298.Suden_2061 5.396e-47 173.0 COG2258@1|root,COG2258@2|Bacteria,1RIAF@1224|Proteobacteria,42VQG@68525|delta/epsilon subdivisions,2YQDM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM MOSC domain - - - - - - - - - - - - MOSC CMS2_k127_3289136_21 563040.Saut_2099 2.587e-30 123.0 2DDD8@1|root,2ZHK8@2|Bacteria,1Q56G@1224|Proteobacteria,42V7B@68525|delta/epsilon subdivisions,2YQI8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulphur oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ CMS2_k127_3289136_18 563040.Saut_2098 1.88e-43 163.0 COG5501@1|root,COG5501@2|Bacteria,1PPTJ@1224|Proteobacteria,430CY@68525|delta/epsilon subdivisions,2YS07@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY CMS2_k127_3289136_10 1165841.SULAR_10684 1.978e-96 327.0 COG3245@1|root,COG3258@1|root,COG3245@2|Bacteria,COG3258@2|Bacteria,1QTYW@1224|Proteobacteria,42WAQ@68525|delta/epsilon subdivisions,2YTG9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrome_CBB3 CMS2_k127_3289136_1 563040.Saut_2096 5.159e-221 692.0 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,42PRR@68525|delta/epsilon subdivisions,2YMYP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S sulfur dehydrogenase subunit soxC - - ko:K17225 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Mo-co_dimer,Oxidored_molyb CMS2_k127_3289136_23 1001530.BACE01000027_gene493 2.342e-11 68.0 COG3103@1|root,COG4991@2|Bacteria,1RC08@1224|Proteobacteria 1224|Proteobacteria T sh3 domain protein - - - - - - - - - - - - - CMS2_k127_3289136_3 563040.Saut_2123 2.734e-181 572.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2YMD9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 CMS2_k127_3289136_19 929558.SMGD1_1200 5.228e-38 144.0 COG0268@1|root,COG0268@2|Bacteria,1NITA@1224|Proteobacteria,42V4U@68525|delta/epsilon subdivisions,2YPUG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p CMS2_k127_3289136_0 1537917.JU82_00535 3.258e-225 705.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2YMNB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS2_k127_3289136_15 1537917.JU82_00530 2.22e-62 217.0 COG0597@1|root,COG0597@2|Bacteria,1Q1GU@1224|Proteobacteria,42TMD@68525|delta/epsilon subdivisions,2YPZS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 CMS2_k127_3289136_4 929558.SMGD1_2841 1.296e-173 551.0 COG1397@1|root,COG1397@2|Bacteria,1PUW9@1224|Proteobacteria,42Z7N@68525|delta/epsilon subdivisions,2YR1W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH CMS2_k127_3289136_5 563040.Saut_2103 1.485e-173 550.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,42MF9@68525|delta/epsilon subdivisions,2YN3Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0005488,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0663 Chorismate_synt CMS2_k127_3289136_11 273121.WS1899 7.23e-87 295.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,42MIP@68525|delta/epsilon subdivisions,2YMPW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm CMS2_k127_3289136_9 929558.SMGD1_1177 1.656e-108 362.0 COG2956@1|root,COG2956@2|Bacteria,1QUIS@1224|Proteobacteria,42M7G@68525|delta/epsilon subdivisions,2YMKN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_7,TPR_8 CMS2_k127_3289136_2 709032.Sulku_0052 1.537e-188 600.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2YMSH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c oxidase accessory protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C CMS2_k127_3289136_20 553219.CAMSH0001_1521 2.514e-37 158.0 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2YMRX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Signal transduction protein - - - - - - - - - - - - HDOD CMS2_k127_3289136_6 1537917.JU82_00570 1.463e-166 528.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2YMNC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS2_k127_3289136_17 1249480.B649_00350 5.154e-44 164.0 COG0575@1|root,COG0575@2|Bacteria,1NDQ6@1224|Proteobacteria,43DJ3@68525|delta/epsilon subdivisions,2YTJ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 CMS2_k127_3307996_4 1150621.SMUL_1184 1.781e-51 191.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42Q51@68525|delta/epsilon subdivisions 1224|Proteobacteria I Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos CMS2_k127_3307996_2 1537915.JU57_05840 1.995e-100 340.0 COG0577@1|root,COG0577@2|Bacteria,1QT4V@1224|Proteobacteria,42P7K@68525|delta/epsilon subdivisions,2YNGD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V ABC transporter permease - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_3307996_7 990073.ATHU01000001_gene682 7.189e-37 150.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42PQP@68525|delta/epsilon subdivisions,2YNQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein ybbA - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_3307996_1 1565314.OA34_09595 3.918e-144 473.0 COG3278@1|root,COG3278@2|Bacteria,1QAUQ@1224|Proteobacteria,42P3Q@68525|delta/epsilon subdivisions,2YNBX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the heme-copper respiratory oxidase family - - - - - - - - - - - - COX1 CMS2_k127_3307996_3 572480.Arnit_3126 5.162e-56 207.0 2AIAA@1|root,318R4@2|Bacteria,1Q0T4@1224|Proteobacteria,42SFV@68525|delta/epsilon subdivisions,2YPR6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - 1.13.11.63 ko:K21817 - - - - ko00000,ko01000 - - - - CMS2_k127_3307996_8 1249480.B649_11295 5.357e-30 126.0 COG2353@1|root,COG2353@2|Bacteria,1PDM9@1224|Proteobacteria,42TFW@68525|delta/epsilon subdivisions,2YQ0K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI CMS2_k127_3307996_10 264462.Bd1064 1.14e-05 57.0 COG1657@1|root,COG1657@2|Bacteria 2|Bacteria I PFAM Prenyltransferase squalene oxidase - - - - - - - - - - - - He_PIG,Prenyltrans CMS2_k127_3307996_6 572480.Arnit_2263 9.557e-40 159.0 2CJ90@1|root,33RG4@2|Bacteria,1Q090@1224|Proteobacteria,42RSY@68525|delta/epsilon subdivisions,2YP4W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Etoposide-induced protein 2.4 (EI24) - - - - - - - - - - - - EI24 CMS2_k127_3307996_0 709032.Sulku_0572 2.332e-218 684.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2YMAH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the ClpA ClpB family clpB - - ko:K03694,ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N CMS2_k127_3312107_10 1249480.B649_05415 4.363e-49 179.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2YMD8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin por - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C CMS2_k127_3312107_5 880073.Calab_1546 1.337e-89 305.0 COG0167@1|root,COG0167@2|Bacteria,2NPB9@2323|unclassified Bacteria 2|Bacteria F Catalyzes the conversion of dihydroorotate to orotate - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh CMS2_k127_3312107_2 1249480.B649_01060 1.367e-142 456.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,42M1Y@68525|delta/epsilon subdivisions,2YMJA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hydrolase aguB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase CMS2_k127_3312107_8 929558.SMGD1_1673 1.863e-84 287.0 COG2214@1|root,COG2214@2|Bacteria,1QV0K@1224|Proteobacteria,42RGB@68525|delta/epsilon subdivisions 1224|Proteobacteria O DnaJ domain protein - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ CMS2_k127_3312107_12 156889.Mmc1_1309 2.391e-16 87.0 COG2356@1|root,COG2356@2|Bacteria,1MXQM@1224|Proteobacteria,2UEGK@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Endonuclease I - - 3.1.21.1 ko:K01150 - - - - ko00000,ko01000 - - - Endonuclease_1 CMS2_k127_3312107_6 929558.SMGD1_1674 6.407e-86 296.0 COG1672@1|root,COG1672@2|Bacteria,1PMVJ@1224|Proteobacteria,42PCP@68525|delta/epsilon subdivisions,2YNZF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM Archaea bacterial proteins of - - - ko:K06921 - - - - ko00000 - - - DUF234 CMS2_k127_3312107_11 1151117.AJLF01000001_gene1057 3.333e-29 126.0 COG0584@1|root,arCOG00701@2157|Archaea,2XXRI@28890|Euryarchaeota,243A7@183968|Thermococci 183968|Thermococci C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD CMS2_k127_3312107_1 929558.SMGD1_0189 5.63e-166 528.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2YMY2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C C-terminal domain of alpha-glycerophosphate oxidase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C CMS2_k127_3312107_4 326298.Suden_0312 5.331e-99 331.0 COG2996@1|root,COG2996@2|Bacteria,1MXC3@1224|Proteobacteria,42P2A@68525|delta/epsilon subdivisions,2YMVD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S S1 domain - - - ko:K00243 - - - - ko00000 - - - S1_2 CMS2_k127_3312107_3 709032.Sulku_2604 4.003e-101 342.0 COG3213@1|root,COG3213@2|Bacteria,1QDV8@1224|Proteobacteria,42Q6A@68525|delta/epsilon subdivisions,2YNFJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P protein involved in response to NO - - - ko:K07234 - - - - ko00000 - - - NnrS CMS2_k127_3312107_7 1167006.UWK_00355 1.312e-85 304.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43CPN@68525|delta/epsilon subdivisions 1224|Proteobacteria T GGDEF domain - - - - - - - - - - - - CHASE,GAF_2,GGDEF,PAS_3,PAS_4,PAS_8,PAS_9,PocR,dCache_3 CMS2_k127_3312107_9 1172190.M947_10875 3.685e-55 196.0 COG3399@1|root,COG3399@2|Bacteria,1Q5AE@1224|Proteobacteria,430WQ@68525|delta/epsilon subdivisions,2YS0M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - ko:K09943 - - - - ko00000 - - - - CMS2_k127_3312107_0 1026882.MAMP_00824 1.132e-198 625.0 COG1944@1|root,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,1RN47@1236|Gammaproteobacteria,45ZWA@72273|Thiotrichales 72273|Thiotrichales O YcaO cyclodehydratase, ATP-ad Mg2+-binding - - - ko:K09136 - - - - ko00000,ko03009 - - - YcaO CMS2_k127_3319390_9 929558.SMGD1_1211 7.402e-104 342.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2YMEM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I CMS2_k127_3319390_16 709032.Sulku_2500 2.494e-48 177.0 COG0352@1|root,COG0352@2|Bacteria,1P3Q4@1224|Proteobacteria,42SIF@68525|delta/epsilon subdivisions,2YPJ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H thiamine-phosphate diphosphorylase activity - - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - - CMS2_k127_3319390_13 563040.Saut_2134 5.26e-71 246.0 COG4106@1|root,COG4106@2|Bacteria,1QZ2S@1224|Proteobacteria,43CEU@68525|delta/epsilon subdivisions,2YTCB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Methyltransferase domain - - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25 CMS2_k127_3319390_8 929558.SMGD1_1214 4.474e-104 344.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2YMMF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Abc transporter - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 CMS2_k127_3319390_10 563040.Saut_2136 8.525e-100 331.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,42NI8@68525|delta/epsilon subdivisions,2YMKV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran CMS2_k127_3319390_14 929558.SMGD1_1216 2.182e-64 231.0 COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2YQ8H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the bacterial solute-binding protein 9 family - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA CMS2_k127_3319390_17 1537917.JU82_04105 1.724e-37 144.0 COG1314@1|root,COG1314@2|Bacteria,1NJ1D@1224|Proteobacteria,42TKW@68525|delta/epsilon subdivisions,2YPUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Preprotein translocase subunit SecG secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG CMS2_k127_3319390_7 1123326.JFBL01000005_gene1067 4.127e-105 349.0 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,42PMY@68525|delta/epsilon subdivisions,2YMBR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 CMS2_k127_3319390_11 563040.Saut_2139 3.019e-77 262.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2YMYI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF CMS2_k127_3319390_6 326298.Suden_2068 8.193e-106 347.0 COG0461@1|root,COG0461@2|Bacteria,1RIC5@1224|Proteobacteria,42M91@68525|delta/epsilon subdivisions,2YMTS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran CMS2_k127_3319390_5 317025.Tcr_1107 2.918e-124 406.0 COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,45ZQC@72273|Thiotrichales 72273|Thiotrichales HJ Sugar-transfer associated ATP-grasp - - - - - - - - - - - - ATPgrasp_ST CMS2_k127_3319390_4 1165841.SULAR_09494 5.844e-130 431.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,42U1I@68525|delta/epsilon subdivisions 1224|Proteobacteria E 7 transmembrane helices usually fused to an inactive transglutaminase IV02_00930 - - - - - - - - - - - 7TM_transglut,Transglut_i_TM CMS2_k127_3319390_18 1165841.SULAR_09499 7.063e-31 130.0 COG4067@1|root,COG4067@2|Bacteria,1N0VV@1224|Proteobacteria,43B1S@68525|delta/epsilon subdivisions 1224|Proteobacteria O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease CMS2_k127_3319390_3 709032.Sulku_2512 5.279e-182 585.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2YMWQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N CMS2_k127_3319390_0 929558.SMGD1_1221 3.717e-310 954.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2YMUF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase CMS2_k127_3319390_1 929558.SMGD1_1222 1.057e-207 657.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,42MYF@68525|delta/epsilon subdivisions,2YMXD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Single-stranded-DNA-specific exonuclease (RecJ) recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 CMS2_k127_3319390_2 709032.Sulku_2030 2.193e-194 616.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42NYV@68525|delta/epsilon subdivisions,2YN1D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS2_k127_3319390_15 709032.Sulku_0974 6.675e-54 208.0 COG3206@1|root,COG3206@2|Bacteria,1Q26P@1224|Proteobacteria,42V2K@68525|delta/epsilon subdivisions,2YQ9I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - - CMS2_k127_3319390_19 487796.Flav2ADRAFT_0280 3.765e-29 121.0 2DPMI@1|root,332NY@2|Bacteria,4NWET@976|Bacteroidetes,1II5Y@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DoxX CMS2_k127_3319390_12 709032.Sulku_1817 1.099e-74 277.0 COG2319@1|root,COG2319@2|Bacteria,1Q4KY@1224|Proteobacteria,42ZEF@68525|delta/epsilon subdivisions,2YR4A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S WD40 repeats - - - - - - - - - - - - - CMS2_k127_3319390_21 498211.CJA_2990 2.412e-13 77.0 COG3187@1|root,COG3187@2|Bacteria,1N9XV@1224|Proteobacteria,1S4T0@1236|Gammaproteobacteria,1FHK2@10|Cellvibrio 1236|Gammaproteobacteria O META domain - - - ko:K09914 - - - - ko00000 - - - META,NlpE,NlpE_C,YscW CMS2_k127_3320892_9 929558.SMGD1_1340 2.608e-59 211.0 COG1120@1|root,COG1120@2|Bacteria,1PFA0@1224|Proteobacteria,42UVB@68525|delta/epsilon subdivisions,2YPUB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HP COGs COG1120 ABC-type cobalamin Fe3 -siderophores transport systems ATPase components - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran CMS2_k127_3320892_5 929558.SMGD1_1339 2.938e-107 356.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42R7K@68525|delta/epsilon subdivisions,2YP16@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD CMS2_k127_3320892_8 1172190.M947_06690 2.123e-63 220.0 2AIVI@1|root,319CU@2|Bacteria,1Q2CK@1224|Proteobacteria,42UBC@68525|delta/epsilon subdivisions,2YPZT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3320892_6 387092.NIS_1744 4.032e-78 268.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,42Q44@68525|delta/epsilon subdivisions,2YNTJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 CMS2_k127_3320892_2 1537917.JU82_06325 9.759e-146 466.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,42MJU@68525|delta/epsilon subdivisions,2YM7H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M UTP-glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0646 NTP_transferase CMS2_k127_3320892_12 1123518.ARWI01000001_gene258 2.896e-43 168.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - Autoind_bind,GerE CMS2_k127_3320892_11 749222.Nitsa_0052 4.591e-51 184.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2YPMF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG CMS2_k127_3320892_4 944547.ABLL_2336 7.216e-116 388.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2YMWG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U COG1459 Type II secretory pathway, component PulF - - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF CMS2_k127_3320892_15 598659.NAMH_0012 3.004e-11 74.0 COG0506@1|root,COG0506@2|Bacteria,1Q2W5@1224|Proteobacteria,42WCB@68525|delta/epsilon subdivisions,2YQK4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E proline dehydrogenase activity - - - - - - - - - - - - - CMS2_k127_3320892_13 1123326.JFBL01000017_gene2324 1.346e-15 87.0 2A9R8@1|root,30YYK@2|Bacteria,1PKV5@1224|Proteobacteria,42XYU@68525|delta/epsilon subdivisions,2YQWH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3320892_14 944547.ABLL_2332 3.526e-14 79.0 2A4Y3@1|root,30TJW@2|Bacteria,1PDG3@1224|Proteobacteria,42X3Z@68525|delta/epsilon subdivisions,2YQTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3320892_18 224324.aq_1450 0.000541 51.0 COG0265@1|root,COG0265@2|Bacteria,2G3MU@200783|Aquificae 200783|Aquificae M PFAM peptidase S1 and S6 chymotrypsin Hap htrA - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS2_k127_3320892_3 944547.ABLL_2330 9.515e-123 415.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2YNRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU general secretion pathway protein D - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N CMS2_k127_3320892_1 944547.ABLL_2329 1.078e-177 570.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE CMS2_k127_3320892_16 1165841.SULAR_08652 1.271e-09 66.0 2BSET@1|root,32MGT@2|Bacteria,1Q39R@1224|Proteobacteria,42WZN@68525|delta/epsilon subdivisions,2YQU4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl CMS2_k127_3320892_7 994573.T472_0215450 7.316e-68 260.0 29DE2@1|root,300BX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_3320892_0 1336803.PHEL49_0142 1.947e-204 653.0 COG3228@1|root,COG3228@2|Bacteria,4NG95@976|Bacteroidetes,1HXW0@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the MtfA family - - - - - - - - - - - - Mrr_cat CMS2_k127_3331478_1 1172190.M947_09185 2.534e-52 186.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,42SGM@68525|delta/epsilon subdivisions,2YPJ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p CMS2_k127_3331478_2 1537917.JU82_04580 2.589e-44 161.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2YQ0A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 CMS2_k127_3331478_0 1537917.JU82_04585 9.77e-158 504.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2YMGX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 CMS2_k127_3357512_3 387092.NIS_0260 5.344e-14 71.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2YMZW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 CMS2_k127_3357512_2 709032.Sulku_2277 3.647e-24 101.0 COG0267@1|root,COG0267@2|Bacteria,1NJ67@1224|Proteobacteria 1224|Proteobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 CMS2_k127_3357512_4 1537917.JU82_01700 1.431e-13 74.0 COG0690@1|root,COG0690@2|Bacteria,1N8YN@1224|Proteobacteria,42VP0@68525|delta/epsilon subdivisions,2YQ7E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE CMS2_k127_3357512_0 709032.Sulku_2275 1.6e-88 294.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2YMJK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG CMS2_k127_3357512_1 709032.Sulku_2274 3.993e-57 201.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2YNWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N CMS2_k127_3363939_1 944547.ABLL_2639 2.265e-75 260.0 COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2YM7Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867,NAD_binding_10 CMS2_k127_3363939_0 1165841.SULAR_01878 2.102e-156 495.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2YMH1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_3390152_1 1123326.JFBL01000008_gene424 6.412e-93 315.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2YMC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Long-chain fatty acid transport protein - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X CMS2_k127_3390152_0 1249480.B649_01125 2.804e-204 647.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C CMS2_k127_3420541_5 929558.SMGD1_0403 5.276e-165 522.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2YNFG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.20.2.1,1.20.9.1,1.7.7.2 ko:K00367,ko:K00372,ko:K08356 ko00910,ko01120,map00910,map01120 M00531 R00791,R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.6 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS2_k127_3420541_2 1249480.B649_07120 2.546e-235 737.0 COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,42QHG@68525|delta/epsilon subdivisions,2YN5C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - ko:K07307 ko00920,map00920 - R09501 RC02555 ko00000,ko00001,ko02000 5.A.3.3 - - DmsC,Fer4_11,Fer4_4 CMS2_k127_3420541_3 1165841.SULAR_05208 1.941e-227 710.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,42PGA@68525|delta/epsilon subdivisions,2YMBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG2223 Nitrate nitrite transporter - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 CMS2_k127_3420541_1 709032.Sulku_1376 4.737e-241 755.0 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2YNMJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KLT COG0631 Serine threonine protein phosphatase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PP2C_2,Pkinase CMS2_k127_3420541_7 929558.SMGD1_0425 9.212e-83 291.0 28NUA@1|root,2ZBSQ@2|Bacteria,1QE31@1224|Proteobacteria,42Z7U@68525|delta/epsilon subdivisions,2YR9R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3420541_6 929558.SMGD1_0426 1.238e-141 458.0 COG0265@1|root,COG0265@2|Bacteria,1NVFS@1224|Proteobacteria,42Z4E@68525|delta/epsilon subdivisions,2YRIR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Peptidase s1 - - - - - - - - - - - - Trypsin_2 CMS2_k127_3420541_9 1537917.JU82_05300 3.679e-67 234.0 COG2928@1|root,COG2928@2|Bacteria,1PKH9@1224|Proteobacteria,42XVN@68525|delta/epsilon subdivisions,2YQSF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 CMS2_k127_3420541_10 580332.Slit_2205 2.336e-51 185.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,44VT6@713636|Nitrosomonadales 28216|Betaproteobacteria O Thioredoxin trxC - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin CMS2_k127_3420541_4 929558.SMGD1_0241 9.851e-178 581.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YMHP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_4 CMS2_k127_3420541_0 326298.Suden_0712 1.063e-277 867.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,42MUY@68525|delta/epsilon subdivisions,2YMZF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E PFAM peptidase M3A and M3B thimet oligopeptidase F prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 CMS2_k127_3420541_8 709032.Sulku_1862 6.698e-72 248.0 COG2374@1|root,COG2374@2|Bacteria,1RCTI@1224|Proteobacteria,42Q2J@68525|delta/epsilon subdivisions,2YNG1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos CMS2_k127_3447438_5 563040.Saut_0750 2.652e-66 228.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2YM8T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the TrpC family trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS CMS2_k127_3447438_2 1172190.M947_02290 6.109e-115 388.0 COG0457@1|root,COG0457@2|Bacteria,1Q55C@1224|Proteobacteria,42RCA@68525|delta/epsilon subdivisions,2YND3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S chaperone-mediated protein folding - - - - - - - - - - - - PPR CMS2_k127_3447438_8 306263.Cla_0924 2.613e-45 168.0 COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42THI@68525|delta/epsilon subdivisions,2YPYY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterised protein family (UPF0153) - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC CMS2_k127_3447438_4 326298.Suden_0728 9.667e-89 299.0 COG4123@1|root,COG4123@2|Bacteria,1RDSC@1224|Proteobacteria,42RIN@68525|delta/epsilon subdivisions,2YP8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S methyltransferase - - - - - - - - - - - - MTS CMS2_k127_3447438_1 709032.Sulku_1749 8.464e-117 379.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,42PTX@68525|delta/epsilon subdivisions,2YMNS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 CMS2_k127_3447438_3 929558.SMGD1_2488 4.714e-110 360.0 2BUD7@1|root,32PP4@2|Bacteria,1Q4AN@1224|Proteobacteria,42YRC@68525|delta/epsilon subdivisions,2YR91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3447438_0 1537917.JU82_10015 1.588e-138 451.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,42NU0@68525|delta/epsilon subdivisions,2YN8B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM HI0933 family protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like CMS2_k127_3447438_9 990073.ATHU01000001_gene146 1.086e-18 88.0 COG1254@1|root,COG1254@2|Bacteria,1Q88S@1224|Proteobacteria,42WDB@68525|delta/epsilon subdivisions,2YQCS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the acylphosphatase family - - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase CMS2_k127_3447438_6 929558.SMGD1_0962 9.118e-64 228.0 COG0767@1|root,COG0767@2|Bacteria,1NSBS@1224|Proteobacteria,42ZGY@68525|delta/epsilon subdivisions 1224|Proteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS2_k127_3447438_11 56780.SYN_01689 1.998e-09 65.0 COG1119@1|root,COG1119@2|Bacteria 2|Bacteria P ATPase activity ylmA - 3.6.3.34 ko:K02013,ko:K05776 ko02010,map02010 M00189,M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran CMS2_k127_3447438_7 1172190.M947_07320 4.921e-51 192.0 COG1463@1|root,COG1463@2|Bacteria,1R565@1224|Proteobacteria 1224|Proteobacteria Q Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD CMS2_k127_3447438_10 1005048.CFU_1965 8.233e-12 74.0 29DRS@1|root,300PM@2|Bacteria,1RF8B@1224|Proteobacteria,2VR3X@28216|Betaproteobacteria,4775S@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3478172_25 1034943.BN1094_00290 3.782e-43 176.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1JFDY@118969|Legionellales 118969|Legionellales Q COG2931 RTX toxins and related Ca2 -binding proteins rtxA2_1 - - - - - - - - - - - Cadherin_3,HemolysinCabind CMS2_k127_3478172_18 525898.Sdel_0791 2.433e-61 218.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,42QWJ@68525|delta/epsilon subdivisions,2YNVX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 CMS2_k127_3478172_11 1249480.B649_07380 4.189e-128 432.0 COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,42PV8@68525|delta/epsilon subdivisions,2YMZX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,LapD_MoxY_N CMS2_k127_3478172_16 563040.Saut_0956 3.659e-76 261.0 COG2230@1|root,COG2230@2|Bacteria,1QZ24@1224|Proteobacteria,43CEA@68525|delta/epsilon subdivisions,2YTBV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Methionine biosynthesis protein MetW - - - - - - - - - - - - CMAS CMS2_k127_3478172_23 563040.Saut_1046 1.717e-54 197.0 COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,42VAD@68525|delta/epsilon subdivisions,2YPP1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_23,TehB CMS2_k127_3478172_17 556268.OFAG_02068 6.066e-68 236.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2VPEY@28216|Betaproteobacteria,474NJ@75682|Oxalobacteraceae 28216|Betaproteobacteria E LysE type translocator leuE_1 - - - - - - - - - - - LysE CMS2_k127_3478172_19 640081.Dsui_2999 3.605e-61 227.0 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2WGMB@28216|Betaproteobacteria,2KZXX@206389|Rhodocyclales 1224|Proteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HAMP,HATPase_c,HisKA CMS2_k127_3478172_6 1249480.B649_05255 5.584e-183 580.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42QH4@68525|delta/epsilon subdivisions,2YNGA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria JKL Belongs to the DEAD box helicase family - - - - - - - - - - - - DEAD,Helicase_C CMS2_k127_3478172_32 572480.Arnit_1311 7.513e-21 96.0 COG2143@1|root,COG2143@2|Bacteria,1R0ZR@1224|Proteobacteria,43D49@68525|delta/epsilon subdivisions,2YTGG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredoxin_7 CMS2_k127_3478172_34 387093.SUN_0799 1.5e-10 67.0 COG3439@1|root,COG3439@2|Bacteria,1RHJQ@1224|Proteobacteria,42X8S@68525|delta/epsilon subdivisions,2YQZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 CMS2_k127_3478172_30 387093.SUN_1059 9.426e-26 112.0 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,42T86@68525|delta/epsilon subdivisions,2YPHR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese CMS2_k127_3478172_3 1172190.M947_00965 1.595e-200 649.0 COG5001@1|root,COG5001@2|Bacteria,1QR8J@1224|Proteobacteria,42ZBG@68525|delta/epsilon subdivisions,2YR24@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF CMS2_k127_3478172_1 563040.Saut_1076 9.41e-321 987.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,42N0P@68525|delta/epsilon subdivisions,2YN14@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C UPF0313 protein - - - - - - - - - - - - Radical_SAM,Radical_SAM_N CMS2_k127_3478172_0 929558.SMGD1_2712 0.0 1071.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YR2T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG1033 exporter of the RND superfamily protein - - - ko:K07003 - - - - ko00000 - - - MMPL CMS2_k127_3478172_10 929558.SMGD1_2711 1.305e-132 426.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42QPE@68525|delta/epsilon subdivisions,2YRPR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like CMS2_k127_3478172_5 929558.SMGD1_2710 6.248e-189 601.0 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,42PXB@68525|delta/epsilon subdivisions 1224|Proteobacteria T Sh3 type 3 domain protein - - - - - - - - - - - - AMIN,DUF1302 CMS2_k127_3478172_35 1121423.JONT01000001_gene2002 1.499e-09 64.0 COG2846@1|root,COG2846@2|Bacteria,1VGYW@1239|Firmicutes,24RAK@186801|Clostridia,262TG@186807|Peptococcaceae 186801|Clostridia D Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin CMS2_k127_3478172_29 563040.Saut_1080 5.22e-30 121.0 COG1188@1|root,COG1188@2|Bacteria,1Q5X3@1224|Proteobacteria,42VKA@68525|delta/epsilon subdivisions,2YPZ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J S4 domain protein - - - - - - - - - - - - S4 CMS2_k127_3478172_9 929558.SMGD1_2610 1.166e-145 467.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2YN78@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase,Glycos_trans_3N,Glycos_transf_3 CMS2_k127_3478172_24 709032.Sulku_0952 2.516e-48 177.0 COG0802@1|root,COG0802@2|Bacteria,1Q97W@1224|Proteobacteria,42TIG@68525|delta/epsilon subdivisions,2YPKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ATPase or kinase tsaE - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE CMS2_k127_3478172_12 929558.SMGD1_2612 2.179e-116 378.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2YMZ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ABC transporter, ATP-binding protein lptB - - ko:K01990,ko:K06861 ko02010,map02010 M00254,M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1,3.A.1 - - ABC_tran,BCA_ABC_TP_C CMS2_k127_3478172_4 563040.Saut_1084 1.518e-196 619.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2YMHJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD CMS2_k127_3478172_14 1172190.M947_00800 9.404e-92 308.0 COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2YNKT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L tigr02757 - - - - - - - - - - - - DUF2400 CMS2_k127_3478172_36 1279017.AQYJ01000028_gene2388 2.617e-07 59.0 2E6EA@1|root,3311R@2|Bacteria,1PFMW@1224|Proteobacteria,1SIKE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl CMS2_k127_3478172_28 608538.HTH_1059 1.041e-32 130.0 COG2050@1|root,COG2050@2|Bacteria,2G4YJ@200783|Aquificae 200783|Aquificae Q Domain of unknown function (DUF4442) - - - - - - - - - - - - 4HBT CMS2_k127_3478172_13 1249480.B649_08005 8.175e-112 364.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2YN03@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A CMS2_k127_3478172_20 709032.Sulku_0821 6.621e-59 209.0 COG0352@1|root,COG0352@2|Bacteria,1NMR6@1224|Proteobacteria,42TSZ@68525|delta/epsilon subdivisions,2YPHK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Thiamine monophosphate synthase - - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI CMS2_k127_3478172_2 1172190.M947_00240 2.935e-247 769.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2YMGC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey CMS2_k127_3478172_7 709032.Sulku_0823 6.64e-152 496.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2YNJR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P potassium channel protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2,TrkA_C,TrkA_N CMS2_k127_3478172_21 709032.Sulku_0824 3.706e-58 209.0 COG1226@1|root,COG1226@2|Bacteria,1R0RZ@1224|Proteobacteria,42UWU@68525|delta/epsilon subdivisions,2YQ24@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TrkA-N domain - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - TrkA_C,TrkA_N CMS2_k127_3478172_8 929558.SMGD1_2323 5.248e-147 469.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2YMSA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iIT341.HP0961 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N CMS2_k127_3478172_27 1165841.SULAR_00965 6.097e-35 136.0 2EKI4@1|root,33E83@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_3478172_26 880071.Fleli_2101 4.771e-37 154.0 28HAZ@1|root,2Z7N5@2|Bacteria,4NH23@976|Bacteroidetes,47MQC@768503|Cytophagia 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - CMS2_k127_3478172_31 1150600.ADIARSV_0475 3.687e-24 109.0 2CGGN@1|root,2ZX47@2|Bacteria,4NNTI@976|Bacteroidetes 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - CMS2_k127_3478172_15 153721.MYP_2945 4.921e-88 328.0 COG1511@1|root,COG1511@2|Bacteria,4PKNX@976|Bacteroidetes,47XXR@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF3584) - - - - - - - - - - - - DUF3584 CMS2_k127_3478172_22 1304888.ATWF01000001_gene1905 4.635e-56 212.0 COG0840@1|root,COG0840@2|Bacteria 2|Bacteria NT transmembrane signaling receptor activity - - - - - - - - - - - - MCPsignal,PAS_9 CMS2_k127_348980_3 1385519.N801_10160 1.872e-09 64.0 2DK6R@1|root,32UEG@2|Bacteria,2INPY@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF4234) - - - - - - - - - - - - DUF4234 CMS2_k127_348980_1 929558.SMGD1_1520 3.458e-229 733.0 COG2887@1|root,COG2887@2|Bacteria,1QUIU@1224|Proteobacteria,42M7I@68525|delta/epsilon subdivisions,2YMX0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG3893 inactivated superfamily I helicase addB - - - - - - - - - - - PDDEXK_1 CMS2_k127_348980_0 929558.SMGD1_1521 1.517e-283 898.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2YMVS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C CMS2_k127_348980_4 314285.KT71_09662 0.0003508 50.0 COG3637@1|root,COG3637@2|Bacteria,1RI4B@1224|Proteobacteria,1S8IK@1236|Gammaproteobacteria,1J6HR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl CMS2_k127_348980_2 563040.Saut_1947 2.052e-75 254.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,42SD5@68525|delta/epsilon subdivisions,2YP70@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 CMS2_k127_3493031_0 643648.Slip_2086 9.696e-99 332.0 COG2801@1|root,COG2801@2|Bacteria,1TSXX@1239|Firmicutes,24C90@186801|Clostridia 186801|Clostridia L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28,rve CMS2_k127_3512313_2 1172190.M947_09025 5.551e-190 597.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2YM8C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 CMS2_k127_3512313_7 1537917.JU82_08675 5.505e-37 143.0 COG1699@1|root,COG1699@2|Bacteria,1N347@1224|Proteobacteria,42RNU@68525|delta/epsilon subdivisions,2YPKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW CMS2_k127_3512313_0 929558.SMGD1_0351 2.835e-317 983.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42N29@68525|delta/epsilon subdivisions,2YMFM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA helicase rep - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C CMS2_k127_3512313_3 1537917.JU82_08685 5.769e-177 563.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2YMT3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretion system ctsF - - ko:K02455,ko:K12278 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF CMS2_k127_3512313_1 1537917.JU82_08690 2.303e-288 894.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB ctsE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N CMS2_k127_3512313_6 563040.Saut_0864 7.969e-57 203.0 COG1619@1|root,COG1619@2|Bacteria,1Q23R@1224|Proteobacteria,42UXX@68525|delta/epsilon subdivisions,2YPD5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V proteins homologs of microcin C7 resistance protein MccF - - - - - - - - - - - - - CMS2_k127_3512313_9 326298.Suden_1385 1.234e-22 108.0 COG0457@1|root,COG0457@2|Bacteria,1Q60C@1224|Proteobacteria,42X29@68525|delta/epsilon subdivisions 1224|Proteobacteria S Anaphase-promoting complex, cyclosome, subunit 3 - - - - - - - - - - - - ANAPC3 CMS2_k127_3512313_5 929558.SMGD1_2294 2.202e-111 365.0 COG3267@1|root,COG3267@2|Bacteria,1QUIM@1224|Proteobacteria,42NAC@68525|delta/epsilon subdivisions,2YNHY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U ATPase (AAA - - 4.3.3.7 ko:K01714,ko:K12283 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000,ko02044 - - - AAA_22 CMS2_k127_3512313_4 563040.Saut_0867 2.485e-175 566.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,43BJ2@68525|delta/epsilon subdivisions,2YN49@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II and III secretion system protein ctsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - STN,Secretin,Secretin_N_2 CMS2_k127_3512313_10 1172190.M947_02235 2.313e-16 85.0 2BSDA@1|root,32MF9@2|Bacteria,1Q395@1224|Proteobacteria,42WZ0@68525|delta/epsilon subdivisions,2YQT3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3512313_8 1172190.M947_02230 2.017e-25 107.0 2AIDI@1|root,31TAR@2|Bacteria,1QR0P@1224|Proteobacteria,42TWA@68525|delta/epsilon subdivisions,2YSYQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - PilO CMS2_k127_3588130_4 1537917.JU82_11015 7.869e-05 51.0 2AK46@1|root,31AU1@2|Bacteria,1Q64N@1224|Proteobacteria,432DV@68525|delta/epsilon subdivisions,2YSQ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_3588130_2 326298.Suden_1751 1.93e-148 472.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2YM9Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Enoyl- acyl-carrier-protein reductase NADH fabI GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 CMS2_k127_3588130_3 1537917.JU82_11005 1.701e-89 301.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2YNW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM CMS2_k127_3588130_0 929558.SMGD1_1788 2.018e-202 635.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2YMDF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK CMS2_k127_3588130_1 1165841.SULAR_07485 1.797e-175 554.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2YMUH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N CMS2_k127_3657751_2 929558.SMGD1_1698 1.626e-26 110.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2YMKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT CMS2_k127_3657751_1 1168067.JAGP01000001_gene1805 4.886e-29 123.0 2ESSS@1|root,33KB5@2|Bacteria,1P7H4@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF2628) - - - - - - - - - - - - DUF2628 CMS2_k127_3657751_0 1168067.JAGP01000001_gene1805 1.651e-32 132.0 2ESSS@1|root,33KB5@2|Bacteria,1P7H4@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF2628) - - - - - - - - - - - - DUF2628 CMS2_k127_3657751_3 1318628.MARLIPOL_04345 8.236e-10 63.0 COG1073@1|root,COG1073@2|Bacteria,1RFAF@1224|Proteobacteria,1S2YT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1073 Hydrolases of the alpha beta superfamily yfhR - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 CMS2_k127_3726634_2 929558.SMGD1_1685 1.539e-37 141.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2YM9W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase - - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 CMS2_k127_3726634_1 1249480.B649_01170 3.068e-316 983.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4_10,Molybdopterin,NADH-G_4Fe-4S_3 CMS2_k127_3726634_0 563040.Saut_1828 0.0 1097.0 COG1034@1|root,COG1034@2|Bacteria,1RCFT@1224|Proteobacteria,42NK4@68525|delta/epsilon subdivisions,2YNI6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 CMS2_k127_3835675_2 929558.SMGD1_0973 5.581e-41 154.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2YPXD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p CMS2_k127_3835675_0 709032.Sulku_0205 1.873e-82 276.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,42NSE@68525|delta/epsilon subdivisions,2YMUG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 CMS2_k127_3835675_1 709032.Sulku_0204 5.838e-67 229.0 COG0096@1|root,COG0096@2|Bacteria,1N3R7@1224|Proteobacteria,43AC0@68525|delta/epsilon subdivisions,2YP6G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 CMS2_k127_3845103_1 622637.KE124773_gene4153 1.855e-07 57.0 COG2963@1|root,COG2963@2|Bacteria,1RI5X@1224|Proteobacteria,2UBB0@28211|Alphaproteobacteria,370IT@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 CMS2_k127_3845103_0 1297865.APJD01000051_gene6887 3.637e-82 283.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,3JWTA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 CMS2_k127_3876149_1 526222.Desal_3639 3.66e-41 153.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,42U0I@68525|delta/epsilon subdivisions,2WR0Q@28221|Deltaproteobacteria,2MCK0@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 CMS2_k127_3876149_0 526222.Desal_3640 2.399e-118 387.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,42T3Y@68525|delta/epsilon subdivisions,2WU62@28221|Deltaproteobacteria,2MBJD@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 CMS2_k127_3897051_1 1537917.JU82_00640 7.579e-66 227.0 COG0575@1|root,COG0575@2|Bacteria,1NDQ6@1224|Proteobacteria,43DJ3@68525|delta/epsilon subdivisions,2YTJ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 CMS2_k127_3897051_0 326298.Suden_0126 1.612e-140 451.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,42NI1@68525|delta/epsilon subdivisions,2YMHQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom CMS2_k127_395968_6 929558.SMGD1_0874 1.942e-53 198.0 COG2863@1|root,COG2863@2|Bacteria,1Q4WC@1224|Proteobacteria,42NFN@68525|delta/epsilon subdivisions,2YMWE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Plasminogen-binding protein pgbA N-terminal - - - - - - - - - - - - PGBA_N CMS2_k127_395968_0 929558.SMGD1_0875 6.865e-152 490.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2YMW2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M peptidase M23 - - - - - - - - - - - - Peptidase_M23 CMS2_k127_395968_1 387092.NIS_0344 4.83e-140 458.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2YMTP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N CMS2_k127_395968_3 1249480.B649_10285 9.393e-74 254.0 COG0494@1|root,COG0494@2|Bacteria,1QSQG@1224|Proteobacteria,42RR5@68525|delta/epsilon subdivisions,2YP9Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Nudix domain - - 3.6.1.45 ko:K08077 - - - - ko00000,ko01000 - - - NUDIX CMS2_k127_395968_5 563040.Saut_0707 2.052e-60 218.0 COG2191@1|root,COG2191@2|Bacteria,1RD60@1224|Proteobacteria,42SP8@68525|delta/epsilon subdivisions,2YPEF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Formylmethanofuran dehydrogenase, subunit e - - - - - - - - - - - - FmdE CMS2_k127_395968_2 1172190.M947_03715 5.309e-89 300.0 COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,42NNI@68525|delta/epsilon subdivisions,2YNBH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) cmoA GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25,Methyltransf_31 CMS2_k127_395968_7 1123326.JFBL01000012_gene55 7.626e-15 78.0 2BSV5@1|root,32MYQ@2|Bacteria,1Q3GB@1224|Proteobacteria,42XA1@68525|delta/epsilon subdivisions,2YQPY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_395968_4 387092.NIS_0557 2.534e-71 247.0 COG2195@1|root,COG2195@2|Bacteria,1MUWK@1224|Proteobacteria,42PS0@68525|delta/epsilon subdivisions,2YMQC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Dipeptidase pepD - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M20 CMS2_k127_4031418_0 177437.HRM2_11310 9.923e-128 417.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2MIEH@213118|Desulfobacterales 28221|Deltaproteobacteria NU type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N CMS2_k127_4070213_27 1165841.SULAR_00990 8.3e-102 331.0 COG1013@1|root,COG1013@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor forB2 - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C CMS2_k127_4070213_4 1165841.SULAR_00985 4.654e-233 723.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2YMD8@29547|Epsilonproteobacteria 68525|delta/epsilon subdivisions C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N CMS2_k127_4070213_16 1165841.SULAR_00980 2.493e-145 462.0 COG0226@1|root,COG0226@2|Bacteria 2|Bacteria P phosphate ion binding forD - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - CO_dh,PBP_like_2 CMS2_k127_4070213_0 1165841.SULAR_01080 0.0 1341.0 COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,42ZJD@68525|delta/epsilon subdivisions 1224|Proteobacteria S Belongs to the UPF0753 family - - - ko:K09822 - - - - ko00000 - - - DUF2309 CMS2_k127_4070213_3 1165841.SULAR_01085 6.242e-252 786.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2YN0B@29547|Epsilonproteobacteria 68525|delta/epsilon subdivisions CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit - - - - - - - - - - - - Proton_antipo_M,Proton_antipo_N CMS2_k127_4070213_37 1165841.SULAR_01000 1.217e-41 154.0 COG1144@1|root,COG1144@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor forE - 1.2.7.1 ko:K00171,ko:K00172,ko:K02573,ko:K13795,ko:K18930 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4,Fer4_21,Fer4_4,Fer4_7,POR CMS2_k127_4070213_23 1165841.SULAR_01095 4.46e-116 375.0 COG0226@1|root,COG0226@2|Bacteria 2|Bacteria P phosphate ion binding - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - CO_dh,PBP_like_2 CMS2_k127_4070213_5 1165841.SULAR_01100 3.092e-226 704.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2YMD8@29547|Epsilonproteobacteria 68525|delta/epsilon subdivisions C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N CMS2_k127_4070213_9 1165841.SULAR_01105 2.375e-173 546.0 COG1013@1|root,COG1013@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor porB - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C CMS2_k127_4070213_20 1165841.SULAR_01110 1.542e-134 430.0 COG1014@1|root,COG1014@2|Bacteria 2|Bacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR CMS2_k127_4070213_8 1165841.SULAR_01115 6.339e-176 554.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,42Q6E@68525|delta/epsilon subdivisions,2YQCG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Cobalamin synthesis protein - - - - - - - - - - - - CobW_C,cobW CMS2_k127_4070213_2 1165841.SULAR_03592 4.607e-297 934.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YRKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0474 Cation transport ATPase - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 CMS2_k127_4070213_40 709032.Sulku_1628 2.262e-36 145.0 COG0745@1|root,COG0745@2|Bacteria,1Q4B8@1224|Proteobacteria,42YSC@68525|delta/epsilon subdivisions,2YR2V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_4070213_21 563040.Saut_0071 2.218e-134 442.0 COG0840@1|root,COG0840@2|Bacteria,1R486@1224|Proteobacteria,42Q5Y@68525|delta/epsilon subdivisions,2YT16@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein - - - - - - - - - - - - CZB,MCPsignal CMS2_k127_4070213_41 1172190.M947_01985 3.354e-34 137.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,42S78@68525|delta/epsilon subdivisions,2YPB8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT Histidine kinase - - - - - - - - - - - - PAS_3 CMS2_k127_4070213_6 929558.SMGD1_2124 7.024e-177 572.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2YMYH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel CMS2_k127_4070213_25 387093.SUN_1207 7.354e-110 364.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2YNV5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox CMS2_k127_4070213_45 990073.ATHU01000001_gene829 8.218e-05 50.0 2AJIW@1|root,31A5Q@2|Bacteria,1Q4ZS@1224|Proteobacteria,4308B@68525|delta/epsilon subdivisions,2YRXE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Phosphate-starvation-inducible E - - - - - - - - - - - - PsiE CMS2_k127_4070213_28 326298.Suden_1691 1.09e-90 306.0 COG0598@1|root,COG0598@2|Bacteria,1NWUN@1224|Proteobacteria,42S8K@68525|delta/epsilon subdivisions,2YPDR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P CorA-like Mg2 transporter protein - - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA CMS2_k127_4070213_38 1123514.KB905899_gene780 3.98e-40 154.0 COG0668@1|root,COG0668@2|Bacteria,1MZKZ@1224|Proteobacteria,1S6N8@1236|Gammaproteobacteria,462SG@72273|Thiotrichales 72273|Thiotrichales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel CMS2_k127_4070213_35 2850.Phatr2037 1.379e-45 177.0 COG1253@1|root,KOG2118@2759|Eukaryota,2XAKT@2836|Bacillariophyta 2836|Bacillariophyta S Domain of unknown function DUF21 - - - ko:K16302 - - - - ko00000,ko02000 9.A.40.3 - - CBS,DUF21 CMS2_k127_4070213_44 1165841.SULAR_02403 4.022e-12 68.0 2DFKD@1|root,2ZS7E@2|Bacteria,1P5EA@1224|Proteobacteria 1224|Proteobacteria S Pfam:DUF1049 - - - - - - - - - - - - LapA_dom CMS2_k127_4070213_30 525898.Sdel_1728 3.336e-78 269.0 COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,42URC@68525|delta/epsilon subdivisions,2YPX0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterised ACR, YagE family COG1723 - - - - - - - - - - - - DUF155 CMS2_k127_4070213_19 929558.SMGD1_1847 5.028e-136 437.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria 1224|Proteobacteria H polyphosphate kinase - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 CMS2_k127_4070213_7 326298.Suden_1136 3.389e-176 569.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,42RCJ@68525|delta/epsilon subdivisions,2YNX9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA CMS2_k127_4070213_13 326298.Suden_1135 1.249e-154 522.0 COG2911@1|root,COG2911@2|Bacteria,1PBYT@1224|Proteobacteria,42T65@68525|delta/epsilon subdivisions,2YPPD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB CMS2_k127_4070213_12 929558.SMGD1_1459 5.426e-156 497.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,42NIA@68525|delta/epsilon subdivisions,2YR33@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HJ Belongs to the RimK family rimK - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK CMS2_k127_4070213_39 944547.ABLL_2659 6.892e-38 146.0 COG4067@1|root,COG4067@2|Bacteria,1RGX8@1224|Proteobacteria,43B1T@68525|delta/epsilon subdivisions 1224|Proteobacteria O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease CMS2_k127_4070213_15 326298.Suden_1688 2.303e-147 473.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,42M7C@68525|delta/epsilon subdivisions,2YTS2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA CMS2_k127_4070213_14 1165841.SULAR_01215 1.234e-148 477.0 COG1363@1|root,COG1363@2|Bacteria,1MWQV@1224|Proteobacteria,42Y9B@68525|delta/epsilon subdivisions,2YR4Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 CMS2_k127_4070213_10 1165841.SULAR_03472 1.301e-168 542.0 COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,42MUQ@68525|delta/epsilon subdivisions,2YMUB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium calcium exchanger membrane - - - ko:K07300 - - - - ko00000,ko02000 2.A.19 - - Na_Ca_ex CMS2_k127_4070213_17 1165841.SULAR_03467 3.392e-140 460.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2YMTP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N CMS2_k127_4070213_33 563040.Saut_1896 8.74e-55 196.0 COG1416@1|root,COG1416@2|Bacteria,1NP3E@1224|Proteobacteria,42TDQ@68525|delta/epsilon subdivisions,2YPN3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE CMS2_k127_4070213_26 1537917.JU82_06720 1.825e-105 351.0 COG3439@1|root,COG3439@2|Bacteria,1Q0BS@1224|Proteobacteria,42RXE@68525|delta/epsilon subdivisions,2YP61@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 CMS2_k127_4070213_24 1537917.JU82_07970 1.517e-113 377.0 COG5000@1|root,COG5000@2|Bacteria,1R0XZ@1224|Proteobacteria,43D3A@68525|delta/epsilon subdivisions,2YTG0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T phosphorelay sensor kinase activity - - - - - - - - - - - - dCache_3 CMS2_k127_4070213_29 709032.Sulku_0443 1.241e-87 294.0 COG0745@1|root,COG0745@2|Bacteria,1Q456@1224|Proteobacteria,42RZX@68525|delta/epsilon subdivisions,2YP60@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_4070213_18 709032.Sulku_0444 2.666e-138 449.0 COG5002@1|root,COG5002@2|Bacteria,1QUJ9@1224|Proteobacteria,42MEB@68525|delta/epsilon subdivisions,2YMXI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA CMS2_k127_4070213_31 563040.Saut_0991 4.881e-69 239.0 COG3474@1|root,COG3474@2|Bacteria,1QZ1T@1224|Proteobacteria,43CE2@68525|delta/epsilon subdivisions,2YTBN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C CMS2_k127_4070213_32 1249480.B649_02195 2.543e-61 215.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,42TET@68525|delta/epsilon subdivisions,2YPK6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY CMS2_k127_4070213_36 387092.NIS_1830 1.038e-44 164.0 COG2033@1|root,COG2033@2|Bacteria,1NNT5@1224|Proteobacteria,42TKZ@68525|delta/epsilon subdivisions,2YPSG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ CMS2_k127_4070213_22 929558.SMGD1_0059 5.425e-117 380.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,42MIC@68525|delta/epsilon subdivisions,2YN8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Thiosulfate-oxidizing multienzyme system protein SoxA - - - ko:K17222 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - - CMS2_k127_4070213_1 1172190.M947_02030 0.0 1055.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2YMSG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the 5'-nucleotidase family soxB - 3.1.3.6,3.1.4.16 ko:K01119,ko:K17224 ko00230,ko00240,ko00920,ko01100,ko01120,map00230,map00240,map00920,map01100,map01120 M00595 R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135,R10151 RC00078,RC00296,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C,Metallophos CMS2_k127_4070213_11 1249480.B649_02215 9.484e-158 512.0 COG4773@1|root,COG4773@2|Bacteria,1QZ1U@1224|Proteobacteria,42PHE@68525|delta/epsilon subdivisions,2YN5J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Receptor - - - - - - - - - - - - OprD CMS2_k127_4070213_43 1249480.B649_02220 3.237e-17 82.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42R7E@68525|delta/epsilon subdivisions,2YNXU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,Omptin CMS2_k127_4070638_2 1165841.SULAR_03322 1.047e-38 147.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2YMK8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA_3 CMS2_k127_4070638_1 1249480.B649_03360 4.092e-39 151.0 2ETDC@1|root,33KX5@2|Bacteria,1P8PA@1224|Proteobacteria,42UDD@68525|delta/epsilon subdivisions,2YPXG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF420) - - - ko:K08976 - - - - ko00000 - - - DUF420 CMS2_k127_4070638_3 1188252.AJYK01000068_gene198 2.111e-24 108.0 COG3350@1|root,COG3350@2|Bacteria,1N0GC@1224|Proteobacteria,1S846@1236|Gammaproteobacteria,1XY38@135623|Vibrionales 135623|Vibrionales S YHS domain - - - - - - - - - - - - YHS CMS2_k127_4070638_0 563040.Saut_0008 7.075e-48 176.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,42N26@68525|delta/epsilon subdivisions 1224|Proteobacteria S PFAM Alpha Beta hydrolase yheT GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0050526,GO:0052689,GO:0071704 - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 CMS2_k127_4081497_0 273121.WS1111 6.611e-125 404.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,42PJ5@68525|delta/epsilon subdivisions,2YNPV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 CMS2_k127_4081497_1 273121.WS1112 6.458e-122 395.0 COG1116@1|root,COG1116@2|Bacteria,1MWZG@1224|Proteobacteria,43CBE@68525|delta/epsilon subdivisions,2YNP5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran CMS2_k127_4081497_2 273121.WS1113 1.337e-104 344.0 COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,42S17@68525|delta/epsilon subdivisions,2YPCG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 CMS2_k127_4084265_1 929558.SMGD1_0642 3.934e-209 653.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2YMJY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1g CMS2_k127_4084265_8 1172190.M947_04675 3.285e-50 181.0 2E94U@1|root,333DN@2|Bacteria,1P6X3@1224|Proteobacteria,42TTX@68525|delta/epsilon subdivisions,2YPST@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4084265_3 563040.Saut_0585 5.82e-144 463.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2YMM9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS2_k127_4084265_0 563040.Saut_0584 7.928e-230 722.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2YM9I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG CMS2_k127_4084265_10 1355368.JART01000002_gene2358 1.703e-21 98.0 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2YPSE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Preprotein translocase yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC CMS2_k127_4084265_5 1537917.JU82_11830 1.636e-123 408.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2YMSR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M apolipoprotein N-acyltransferase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase CMS2_k127_4084265_4 1537917.JU82_11810 8.578e-141 452.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2YMRZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_4084265_9 563040.Saut_1774 2.354e-44 168.0 COG0115@1|root,COG0115@2|Bacteria,1N3ZD@1224|Proteobacteria,42TNN@68525|delta/epsilon subdivisions,2YPU5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH Branched-chain amino acid aminotransferase - - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 CMS2_k127_4084265_7 1537917.JU82_11800 5.13e-52 189.0 2AMMX@1|root,31CI0@2|Bacteria,1Q8WA@1224|Proteobacteria,42UGB@68525|delta/epsilon subdivisions,2YPW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4084265_6 944546.ABED_1077 1.52e-83 280.0 COG1305@1|root,COG1305@2|Bacteria,1RJJ1@1224|Proteobacteria,43B4M@68525|delta/epsilon subdivisions,2YP25@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Acetyltransf_10,Transglut_core CMS2_k127_4084265_2 1537917.JU82_11795 3.342e-152 485.0 COG0583@1|root,COG0583@2|Bacteria,1R8CE@1224|Proteobacteria,42PKW@68525|delta/epsilon subdivisions,2YNJK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate CMS2_k127_4084818_10 1537917.JU82_04790 1.263e-127 417.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2YMUS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the CinA family cinA - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA CMS2_k127_4084818_0 1249480.B649_08165 0.0 1439.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2YMIZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 CMS2_k127_4084818_5 326298.Suden_0773 9.866e-205 645.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2YMZK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase CMS2_k127_4084818_3 1537917.JU82_04810 1.637e-247 770.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2YMS3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH CMS2_k127_4084818_4 1537917.JU82_04815 1.168e-226 707.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2YMSV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E o-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP CMS2_k127_4084818_8 1172190.M947_05210 4.702e-181 572.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,42N1M@68525|delta/epsilon subdivisions,2YN3T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 CMS2_k127_4084818_27 563040.Saut_0856 5.974e-10 62.0 COG1722@1|root,COG1722@2|Bacteria,1Q35M@1224|Proteobacteria,42WTB@68525|delta/epsilon subdivisions,2YQRG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S CMS2_k127_4084818_12 1537917.JU82_04830 4.982e-107 353.0 COG0388@1|root,COG0388@2|Bacteria,1QBMA@1224|Proteobacteria,42PD8@68525|delta/epsilon subdivisions,2YMD1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S hydrolase - - 3.5.5.1 ko:K01501 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase CMS2_k127_4084818_11 1150621.SMUL_0660 2.83e-109 357.0 COG0476@1|root,COG0476@2|Bacteria,1P1FY@1224|Proteobacteria,42PK6@68525|delta/epsilon subdivisions,2YNCI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H involved in molybdopterin and thiamine biosynthesis family 2 - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF CMS2_k127_4084818_19 1254432.SCE1572_50785 6.569e-49 190.0 COG0500@1|root,COG2226@2|Bacteria,1PARM@1224|Proteobacteria,4358M@68525|delta/epsilon subdivisions,2WZJQ@28221|Deltaproteobacteria,2Z29Z@29|Myxococcales 28221|Deltaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 CMS2_k127_4084818_21 342610.Patl_1786 1.397e-33 145.0 COG0454@1|root,COG0456@2|Bacteria,1N506@1224|Proteobacteria,1S97J@1236|Gammaproteobacteria,2Q521@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 CMS2_k127_4084818_26 1537917.JU82_04840 1.179e-19 94.0 COG2863@1|root,COG2863@2|Bacteria,1NBPD@1224|Proteobacteria,42VXS@68525|delta/epsilon subdivisions,2YQ9N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cytochrome - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 CMS2_k127_4084818_9 326298.Suden_0759 2.301e-172 547.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42M54@68525|delta/epsilon subdivisions,2YNPD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E COG0436 Aspartate tyrosine aromatic aminotransferase - - - - - - - - - - - - Aminotran_1_2 CMS2_k127_4084818_22 563040.Saut_1449 1.596e-29 124.0 2AIWB@1|root,319DT@2|Bacteria,1Q2F3@1224|Proteobacteria,42VJD@68525|delta/epsilon subdivisions,2YQCE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4084818_6 563040.Saut_1450 1.467e-198 626.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2YMTZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iIT341.HP0623 Mur_ligase,Mur_ligase_C,Mur_ligase_M CMS2_k127_4084818_24 1172190.M947_08980 8.364e-23 101.0 2BSRI@1|root,32MUE@2|Bacteria,1Q3E8@1224|Proteobacteria,42X6B@68525|delta/epsilon subdivisions,2YQST@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4084818_2 1172190.M947_08990 4.754e-263 829.0 COG1193@1|root,COG1193@2|Bacteria,1QUJI@1224|Proteobacteria,42P7P@68525|delta/epsilon subdivisions,2YMFB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0000018,GO:0008150,GO:0009892,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0080090 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr CMS2_k127_4084818_18 709032.Sulku_1664 4.168e-49 188.0 COG4753@1|root,COG4753@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - Guanylate_cyc,HATPase_c,HisKA,Pkinase,Response_reg,SpoIIE CMS2_k127_4084818_1 929558.SMGD1_2313 1.648e-306 950.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2YM83@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 CMS2_k127_4084818_17 762903.Pedsa_2432 3.427e-56 198.0 COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,1ISZN@117747|Sphingobacteriia 976|Bacteroidetes O Peptide-methionine (R)-S-oxide reductase msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR CMS2_k127_4084818_14 1537917.JU82_11510 6.479e-83 282.0 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2YNYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Hemolysin tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 CMS2_k127_4084818_13 1537917.JU82_11505 2.837e-96 322.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2YMFH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase CMS2_k127_4084818_7 929558.SMGD1_0100 1.108e-186 604.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2YMP3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Highly conserved protein containing a thioredoxin domain - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH CMS2_k127_4084818_23 929558.SMGD1_0099 8.034e-26 111.0 2A1M6@1|root,30PVA@2|Bacteria,1QTJ9@1224|Proteobacteria,42VDW@68525|delta/epsilon subdivisions,2YQIZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF4395) - - - - - - - - - - - - DUF4395 CMS2_k127_4084818_20 1537915.JU57_09700 4.049e-37 143.0 COG1959@1|root,COG1959@2|Bacteria,1N7JE@1224|Proteobacteria,42UAE@68525|delta/epsilon subdivisions,2YPWZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 CMS2_k127_4084818_25 563040.Saut_0385 3.75e-22 105.0 2C42B@1|root,300ZJ@2|Bacteria,1Q6IT@1224|Proteobacteria,4338E@68525|delta/epsilon subdivisions,2YST6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4084818_16 1073999.BN137_4023 1.241e-58 211.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C CMS2_k127_4095847_18 760154.Sulba_0153 7.669e-34 135.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2YMC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Long-chain fatty acid transport protein - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X CMS2_k127_4095847_5 326298.Suden_1835 3.57e-145 463.0 COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,42MYE@68525|delta/epsilon subdivisions,2YMF4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 CMS2_k127_4095847_2 563040.Saut_1352 1.128e-167 531.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,42MVI@68525|delta/epsilon subdivisions,2YMGY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C aldo keto reductase tas - - - - - - - - - - - Aldo_ket_red CMS2_k127_4095847_4 326298.Suden_1840 3.794e-151 490.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2YN35@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Nucleotidyltransferase DNA polymerase involved in DNA repair dinP - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH CMS2_k127_4095847_14 709032.Sulku_0213 5.605e-42 157.0 COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,42TQH@68525|delta/epsilon subdivisions,2YPWS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions ppnP - 2.4.2.1,2.4.2.2 ko:K09913 ko00230,ko00240,map00230,map00240 - R01561,R01570,R01863,R01876,R02147,R02296,R02297 RC00063,RC00122 ko00000,ko00001,ko01000 - - - DUF1255 CMS2_k127_4095847_19 1123263.AUKY01000033_gene1456 5.507e-29 125.0 COG0666@1|root,COG0666@2|Bacteria,1V2DE@1239|Firmicutes,3VP39@526524|Erysipelotrichia 526524|Erysipelotrichia S Ankyrin repeat protein - - - - - - - - - - - - Ank_2,Ank_5 CMS2_k127_4095847_12 1123326.JFBL01000001_gene1448 1.045e-65 233.0 COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,42RKE@68525|delta/epsilon subdivisions,2YP9T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Conserved hypothetical protein (DUF2461) - - - - - - - - - - - - DUF2461 CMS2_k127_4095847_17 929558.SMGD1_0325 4.865e-35 137.0 COG0607@1|root,COG0607@2|Bacteria,1Q652@1224|Proteobacteria,42VPZ@68525|delta/epsilon subdivisions,2YQMY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese CMS2_k127_4095847_7 28229.ND2E_1046 1.37e-91 309.0 COG2992@1|root,COG2992@2|Bacteria,1RD3U@1224|Proteobacteria,1S3RA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S FlgJ-related protein - - - ko:K03796 - - - - ko00000 - GH73 - Glucosaminidase CMS2_k127_4095847_25 929562.Emtol_4191 1.096e-08 68.0 COG0457@1|root,COG0457@2|Bacteria,4NJ1F@976|Bacteroidetes,47NCH@768503|Cytophagia 976|Bacteroidetes S PFAM Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 CMS2_k127_4095847_8 1249480.B649_00735 2.842e-83 279.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2YP63@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII CMS2_k127_4095847_23 326298.Suden_0205 8.905e-15 76.0 2C0BV@1|root,300E8@2|Bacteria,1Q68S@1224|Proteobacteria,432Q2@68525|delta/epsilon subdivisions,2YSMD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4095847_10 929558.SMGD1_2143 2.106e-80 280.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K13040 ko02020,map02020 M00514 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg,SBP_bac_3 CMS2_k127_4095847_15 1165841.SULAR_08157 1.226e-36 144.0 COG2259@1|root,COG2259@2|Bacteria,1RKEE@1224|Proteobacteria,42SF5@68525|delta/epsilon subdivisions,2YPGK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DoxX family - - - ko:K15977 - - - - ko00000 - - - DoxX CMS2_k127_4095847_6 13333.ERN20200 8.777e-112 378.0 COG0265@1|root,KOG1320@2759|Eukaryota,37P6K@33090|Viridiplantae,3G86S@35493|Streptophyta 35493|Streptophyta O protease do-like - - - - - - - - - - - - PDZ_2,Trypsin_2 CMS2_k127_4095847_24 1172190.M947_08440 1.053e-13 79.0 COG0775@1|root,COG0775@2|Bacteria,1QSEF@1224|Proteobacteria,42X56@68525|delta/epsilon subdivisions,2YQPV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively - - - - - - - - - - - - PNP_UDP_1 CMS2_k127_4095847_11 709032.Sulku_0147 3.755e-68 239.0 COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,42RPR@68525|delta/epsilon subdivisions,2YPAJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short CMS2_k127_4095847_21 192222.Cj1294 2.757e-20 102.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2YMNH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the DegT DnrJ EryC1 family pseC - 2.6.1.92 ko:K15895 ko00520,map00520 - R09825 RC00006,RC00781 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 CMS2_k127_4095847_1 1149133.ppKF707_3647 3.082e-179 567.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RQ7S@1236|Gammaproteobacteria,1YDDM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family vioA - 2.6.1.33 ko:K20429 - - R02773 RC00006,RC00781 ko00000,ko01000 - - - DegT_DnrJ_EryC1 CMS2_k127_4095847_9 749222.Nitsa_1727 5.04e-81 273.0 COG0110@1|root,COG0110@2|Bacteria,1NFMZ@1224|Proteobacteria,43AWQ@68525|delta/epsilon subdivisions,2YT3X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0110 Acetyltransferase (isoleucine patch superfamily) - - 2.3.1.209 ko:K21379 - - - - ko00000,ko01000 - - - Hexapep CMS2_k127_4095847_13 1301098.PKB_2544 1.831e-49 205.0 COG2227@1|root,COG2227@2|Bacteria,1QXDE@1224|Proteobacteria,1T38N@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 CMS2_k127_4095847_16 46234.ANA_C13160 4.348e-36 161.0 COG0463@1|root,COG0463@2|Bacteria,1GQ4G@1117|Cyanobacteria,1HN6Q@1161|Nostocales 1117|Cyanobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2,Methyltransf_11 CMS2_k127_4095847_0 1123368.AUIS01000001_gene2104 2.627e-198 681.0 COG0381@1|root,COG1215@1|root,COG1216@1|root,COG2519@1|root,COG0381@2|Bacteria,COG1215@2|Bacteria,COG1216@2|Bacteria,COG2519@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,2NBX8@225057|Acidithiobacillales 225057|Acidithiobacillales M Glycosyltransferase like family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_tranf_2_3,Glycos_transf_2,Methyltransf_23 CMS2_k127_4095847_3 598659.NAMH_1612 9.338e-159 514.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,42MX8@68525|delta/epsilon subdivisions,2YN00@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flaB GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N CMS2_k127_4104408_1 929558.SMGD1_1810 1.266e-304 941.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2YMUE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB CMS2_k127_4104408_0 709032.Sulku_0488 0.0 1037.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2YMKH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N CMS2_k127_4104408_4 929558.SMGD1_0652 4.038e-92 304.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2YN9C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S acetyltransferase - - - - - - - - - - - - Hexapep,Hexapep_2 CMS2_k127_4104408_5 709032.Sulku_0486 2.849e-75 257.0 COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,42R47@68525|delta/epsilon subdivisions,2YP8Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane - - - - - - - - - - - - UPF0126 CMS2_k127_4104408_7 525897.Dbac_0940 3.524e-24 113.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria,2M7QN@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Peptidase M23 - - - - - - - - - - - - Peptidase_M23 CMS2_k127_4104408_2 1249480.B649_01695 7.219e-184 581.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2YMJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ CMS2_k127_4104408_3 572480.Arnit_2236 1.41e-128 421.0 COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2YN0V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Potassium channel protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N CMS2_k127_4104408_6 1537917.JU82_04040 1.515e-27 111.0 COG0227@1|root,COG0227@2|Bacteria,1PTFN@1224|Proteobacteria,42V1S@68525|delta/epsilon subdivisions,2YQAP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 CMS2_k127_4108136_3 709032.Sulku_1992 8.074e-43 160.0 COG3370@1|root,COG3370@2|Bacteria,1N27G@1224|Proteobacteria,42UAJ@68525|delta/epsilon subdivisions,2YPZ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM DsrE DsrF-like family - - - - - - - - - - - - DrsE CMS2_k127_4108136_5 1355368.JART01000002_gene2216 3.356e-29 120.0 COG2768@1|root,COG2768@2|Bacteria,1QZF1@1224|Proteobacteria,43CIA@68525|delta/epsilon subdivisions,2YTCX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7 CMS2_k127_4108136_4 357804.Ping_1764 5.314e-37 151.0 2DBYQ@1|root,32TYF@2|Bacteria,1N2HM@1224|Proteobacteria,1SB6Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4108136_9 387092.NIS_1736 6.076e-17 86.0 2AK3E@1|root,31AT6@2|Bacteria,1Q635@1224|Proteobacteria,432B1@68525|delta/epsilon subdivisions,2YSJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4108136_6 1537917.JU82_09285 4.61e-27 114.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2YT6X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T DnaK suppressor protein dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR CMS2_k127_4108136_1 760154.Sulba_1840 5.812e-56 200.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42RJW@68525|delta/epsilon subdivisions,2YP85@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI CMS2_k127_4108136_2 598659.NAMH_0014 1.014e-44 166.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2YPMF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG CMS2_k127_4108136_0 944547.ABLL_2336 1.327e-120 399.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2YMWG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U COG1459 Type II secretory pathway, component PulF - - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF CMS2_k127_4108136_8 944547.ABLL_2334 5.209e-22 107.0 2A9R8@1|root,30YYK@2|Bacteria,1PKV5@1224|Proteobacteria,42XYU@68525|delta/epsilon subdivisions,2YQWH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4108136_11 1165841.SULAR_08632 2.109e-12 74.0 2A4Y3@1|root,30TJW@2|Bacteria,1PDG3@1224|Proteobacteria,42X3Z@68525|delta/epsilon subdivisions,2YQTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4108136_7 944547.ABLL_2330 5.808e-27 115.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2YNRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU general secretion pathway protein D - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N CMS2_k127_4110603_17 1442598.JABW01000028_gene1020 2.194e-90 311.0 2AY0S@1|root,31Q2B@2|Bacteria,1QMQY@1224|Proteobacteria,42SY0@68525|delta/epsilon subdivisions,2YPGA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Bacteriophage replication gene A protein (GPA) - - - - - - - - - - - - Phage_GPA CMS2_k127_4110603_16 929558.SMGD1_0287 5.867e-91 312.0 COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,42M9T@68525|delta/epsilon subdivisions,2YNP9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the 'phage' integrase family - - - ko:K14059 - - - - ko00000 - - - Arm-DNA-bind_2,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase CMS2_k127_4110603_8 1537915.JU57_12515 1.592e-136 443.0 COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,42QEK@68525|delta/epsilon subdivisions,2YNC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT HD domain - - - - - - - - - - - - HD CMS2_k127_4110603_3 1249480.B649_11680 6.781e-190 605.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2YNM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T ATPase related to phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH CMS2_k127_4110603_35 1349785.BAUG01000006_gene604 0.0001482 51.0 COG1266@1|root,COG1266@2|Bacteria,4NSYU@976|Bacteroidetes 976|Bacteroidetes S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi CMS2_k127_4110603_0 1249480.B649_11265 0.0 1005.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2YM8F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD CMS2_k127_4110603_19 1249627.D779_3144 1.679e-53 203.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1SZDF@1236|Gammaproteobacteria,1X0E2@135613|Chromatiales 135613|Chromatiales T diguanylate cyclase - - - - - - - - - - - - GGDEF CMS2_k127_4110603_1 709032.Sulku_1444 8.953e-256 796.0 COG0579@1|root,COG0579@2|Bacteria,1MUCC@1224|Proteobacteria,42M2Q@68525|delta/epsilon subdivisions,2YMYG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Malate quinone- oxidoreductase mqo GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.5.4 ko:K00116 ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R00360,R00361,R01257 RC00031 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0086 Mqo CMS2_k127_4110603_5 1165841.SULAR_01215 1.378e-151 486.0 COG1363@1|root,COG1363@2|Bacteria,1MWQV@1224|Proteobacteria,42Y9B@68525|delta/epsilon subdivisions,2YR4Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 CMS2_k127_4110603_10 929558.SMGD1_1847 7.457e-135 433.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria 1224|Proteobacteria H polyphosphate kinase - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 CMS2_k127_4110603_4 326298.Suden_1688 7.545e-158 503.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,42M7C@68525|delta/epsilon subdivisions,2YTS2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA CMS2_k127_4110603_21 326298.Suden_1686 1.875e-40 154.0 COG4067@1|root,COG4067@2|Bacteria,1RGX8@1224|Proteobacteria,42U6Y@68525|delta/epsilon subdivisions,2YRSZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease CMS2_k127_4110603_6 572480.Arnit_0835 1.213e-149 478.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,42NIA@68525|delta/epsilon subdivisions,2YR33@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria HJ Belongs to the RimK family rimK - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK CMS2_k127_4110603_31 563040.Saut_0074 3.939e-16 82.0 COG1547@1|root,COG1547@2|Bacteria,1PD94@1224|Proteobacteria,42WUE@68525|delta/epsilon subdivisions,2YQXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF309) - - - - - - - - - - - - DUF309 CMS2_k127_4110603_22 929558.SMGD1_1313 9.804e-39 154.0 COG3137@1|root,COG3137@2|Bacteria,1N2DE@1224|Proteobacteria,42W9S@68525|delta/epsilon subdivisions 1224|Proteobacteria M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 CMS2_k127_4110603_15 709032.Sulku_0060 9.036e-92 314.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,42P57@68525|delta/epsilon subdivisions,2YMGG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like CMS2_k127_4110603_23 709032.Sulku_0059 4.62e-37 146.0 COG1714@1|root,COG1714@2|Bacteria,1N2TA@1224|Proteobacteria 1224|Proteobacteria S RDD family - - - - - - - - - - - - RDD CMS2_k127_4110603_24 1347368.HG964410_gene7545 2.033e-36 157.0 COG2199@1|root,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,4HQBN@91061|Bacilli,1ZDG3@1386|Bacillus 91061|Bacilli T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - 5TM-5TMR_LYT,7TMR-DISM_7TM,GGDEF,dCache_1 CMS2_k127_4110603_7 749222.Nitsa_2079 5.401e-140 454.0 COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,42P5E@68525|delta/epsilon subdivisions,2YN01@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Fad-dependent pyridine nucleotide-disulfide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS2_k127_4110603_26 941824.TCEL_00462 1.794e-29 128.0 COG0775@1|root,COG0775@2|Bacteria,1VCJY@1239|Firmicutes,24CRR@186801|Clostridia,36E12@31979|Clostridiaceae 186801|Clostridia F PFAM purine or other phosphorylase family 1 - - - - - - - - - - - - PNP_UDP_1 CMS2_k127_4110603_12 709032.Sulku_0146 1.763e-115 381.0 COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,42P30@68525|delta/epsilon subdivisions,2YNT6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L radical SAM domain protein - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - CMS2_k127_4110603_18 1172190.M947_08455 5.608e-54 198.0 COG4221@1|root,COG4221@2|Bacteria,1QVCA@1224|Proteobacteria,43D38@68525|delta/epsilon subdivisions,2YTFY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short CMS2_k127_4110603_11 929558.SMGD1_1209 2.94e-119 391.0 COG3439@1|root,COG3439@2|Bacteria,1PWY7@1224|Proteobacteria,42Y9J@68525|delta/epsilon subdivisions,2YRF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - - CMS2_k127_4110603_2 765911.Thivi_4506 1.615e-210 668.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1WYB0@135613|Chromatiales 135613|Chromatiales E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N CMS2_k127_4110603_28 631362.Thi970DRAFT_01182 1.886e-23 107.0 2CJ51@1|root,321BV@2|Bacteria,1R3FV@1224|Proteobacteria,1T67C@1236|Gammaproteobacteria,1X0NH@135613|Chromatiales 135613|Chromatiales S Gluconate 2-dehydrogenase subunit 3 - - - - - - - - - - - - Gluconate_2-dh3 CMS2_k127_4110603_9 929558.SMGD1_1296 2.983e-135 456.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CCF@68525|delta/epsilon subdivisions,2YT42@29547|Epsilonproteobacteria 68525|delta/epsilon subdivisions T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg CMS2_k127_4110603_20 709032.Sulku_1452 6.124e-49 198.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YNJ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF CMS2_k127_4110603_25 326298.Suden_0166 1.286e-31 128.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis - - - ko:K12057 - - - - ko00000,ko02044 3.A.7.11.1 - - AhpC-TSA,Thioredoxin,Thioredoxin_7 CMS2_k127_4110603_32 326298.Suden_0167 2.482e-08 62.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis - - - - - - - - - - - - AhpC-TSA,Redoxin,Thioredoxin,Thioredoxin_9 CMS2_k127_4110603_14 1537917.JU82_04720 5.117e-103 344.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2YN5V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L a g-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 CMS2_k127_4110603_13 653733.Selin_1143 1.784e-105 366.0 COG2202@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K13040 ko02020,map02020 M00514 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3365,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9,PocR,Response_reg CMS2_k127_4111252_1 572480.Arnit_1757 2.952e-292 922.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,42Q4M@68525|delta/epsilon subdivisions,2YN67@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD,Prok-TraM CMS2_k127_4111252_2 572480.Arnit_1756 2.75e-78 264.0 COG3157@1|root,COG3157@2|Bacteria,1MXFB@1224|Proteobacteria,42Q89@68525|delta/epsilon subdivisions,2YNDJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Type VI secretion system effector, Hcp tssD - - ko:K11903 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 - - - T6SS_HCP CMS2_k127_4111252_4 572480.Arnit_1755 1.104e-67 241.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42NY2@68525|delta/epsilon subdivisions 1224|Proteobacteria KLT SMART serine threonine protein kinase pkn1 - 2.7.11.1 ko:K08884,ko:K11912,ko:K12132 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - PEGA,Pkinase,TPR_12,cNMP_binding CMS2_k127_4111252_3 572480.Arnit_1754 2.885e-70 244.0 COG0631@1|root,COG0631@2|Bacteria,1RAJR@1224|Proteobacteria 1224|Proteobacteria T phosphatase stp1 - 3.1.3.16 ko:K01090,ko:K11915 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko02044 - - - PP2C_2 CMS2_k127_4111252_0 572480.Arnit_1753 1.312e-298 950.0 COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,42PG2@68525|delta/epsilon subdivisions,2YMDE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S A blastn search against coding sequences extracted from AL111168.1, CP000025.1, CP000538.1, CP000768.1, CP000814.1 failed to identify a tssM - - ko:K11891 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - IcmF-related,IcmF_C,ImcF-related_N CMS2_k127_41389_19 1448857.JFAP01000007_gene290 9.453e-11 63.0 COG2944@1|root,COG2944@2|Bacteria,1Q2M2@1224|Proteobacteria,42VXE@68525|delta/epsilon subdivisions,2YQ6V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-binding protein - - - - - - - - - - - - - CMS2_k127_41389_4 563040.Saut_1692 6.36e-118 399.0 COG1315@1|root,COG1315@2|Bacteria,1R5P6@1224|Proteobacteria,42MAS@68525|delta/epsilon subdivisions,2YM7Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Flagellar Assembly Protein A - - - - - - - - - - - - FapA CMS2_k127_41389_12 563040.Saut_1691 7.404e-50 186.0 2AIM2@1|root,302EJ@2|Bacteria,1Q99E@1224|Proteobacteria,42ZJ9@68525|delta/epsilon subdivisions,2YRN3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_41389_9 929558.SMGD1_1885 2.771e-86 290.0 2A4ZC@1|root,30TM8@2|Bacteria,1PDIE@1224|Proteobacteria,42X6N@68525|delta/epsilon subdivisions,2YRSB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_41389_0 1537917.JU82_09795 1.568e-188 601.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2YMCR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C CMS2_k127_41389_14 525898.Sdel_1411 1.341e-38 150.0 COG1619@1|root,COG1619@2|Bacteria,1Q23R@1224|Proteobacteria,42UXX@68525|delta/epsilon subdivisions,2YPD5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V proteins homologs of microcin C7 resistance protein MccF - - - - - - - - - - - - - CMS2_k127_41389_2 709032.Sulku_2175 1.326e-136 442.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,42NAS@68525|delta/epsilon subdivisions,2YN3V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the agmatine deiminase family aguA - - - - - - - - - - - PAD_porph CMS2_k127_41389_5 326298.Suden_0379 2.079e-110 370.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2YMB7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N CMS2_k127_41389_8 1123400.KB904746_gene1327 4.341e-88 298.0 COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,1RMZ7@1236|Gammaproteobacteria,46208@72273|Thiotrichales 72273|Thiotrichales J RNA pseudouridylate synthase - - 5.4.99.26 ko:K06175 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_2 CMS2_k127_41389_13 425104.Ssed_4465 2.057e-42 160.0 COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,1RR2X@1236|Gammaproteobacteria,2QC5C@267890|Shewanellaceae 1236|Gammaproteobacteria M NLP P60 protein nlpC - 3.4.17.13 ko:K13694,ko:K13695 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 CMS2_k127_41389_18 1548151.LS70_03915 2.927e-12 68.0 2EHK0@1|root,33BBV@2|Bacteria,1NGIK@1224|Proteobacteria 1224|Proteobacteria - - - - - ko:K06950 - - - - ko00000 - - - Metallothio_Pro CMS2_k127_41389_7 1537917.JU82_10320 2.74e-97 322.0 COG0564@1|root,COG0564@2|Bacteria,1RDAG@1224|Proteobacteria,42SR2@68525|delta/epsilon subdivisions 1224|Proteobacteria J Pseudouridine synthase Z012_05060 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.24,5.4.99.28,5.4.99.29 ko:K06177,ko:K06179,ko:K06180 - - - - ko00000,ko01000,ko03009,ko03016 - - - PseudoU_synth_2 CMS2_k127_41389_11 563040.Saut_1280 1.808e-66 229.0 COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,42SIJ@68525|delta/epsilon subdivisions,2YPP8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L G T U mismatch-specific DNA glycosylase mug - - - - - - - - - - - UDG CMS2_k127_41389_1 929558.SMGD1_0627 6.05e-175 566.0 COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,42N7E@68525|delta/epsilon subdivisions,2YNE7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM EAL domain - - - - - - - - - - - - CBS,EAL,GGDEF CMS2_k127_41389_3 326298.Suden_0617 2.775e-126 436.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42Z31@68525|delta/epsilon subdivisions,2YRAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Hpt sensor hybrid histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg CMS2_k127_41389_10 998674.ATTE01000001_gene3982 3.15e-76 263.0 COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,1RR7M@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type phosphate phosphonate transport system periplasmic component - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd CMS2_k127_41389_6 326298.Suden_0310 2.282e-97 323.0 COG0204@1|root,COG0204@2|Bacteria,1QAEF@1224|Proteobacteria,42YDI@68525|delta/epsilon subdivisions,2YREE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase CMS2_k127_41389_17 929558.SMGD1_1140 9.947e-17 81.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2YNK5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DEAD box helicase family dbpA - 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C CMS2_k127_4146739_2 104623.Ser39006_04151 2.97e-07 59.0 COG5283@1|root,COG5283@2|Bacteria,1NFC9@1224|Proteobacteria,1RSKP@1236|Gammaproteobacteria,402IQ@613|Serratia 1236|Gammaproteobacteria M lytic transglycosylase activity - - - - - - - - - - - - SLT CMS2_k127_4146739_0 349966.DJ58_4429 1.757e-44 180.0 2DBB8@1|root,2Z867@2|Bacteria,1NDFK@1224|Proteobacteria,1S055@1236|Gammaproteobacteria,41GRV@629|Yersinia 1236|Gammaproteobacteria S Protein of unknown function (DUF3383) - - - - - - - - - - - - DUF3383 CMS2_k127_4146739_1 1443113.LC20_03082 1.49e-07 59.0 2DZDP@1|root,32V80@2|Bacteria,1NM65@1224|Proteobacteria,1T0BT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4160709_1 1165841.SULAR_00135 5.663e-188 591.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2YMT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH CMS2_k127_4160709_6 1121267.JHZL01000011_gene1498 2.186e-93 316.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,42MPA@68525|delta/epsilon subdivisions,2YMKT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG CMS2_k127_4160709_4 929558.SMGD1_2647 8.635e-122 428.0 COG3164@1|root,COG3164@2|Bacteria,1NSC1@1224|Proteobacteria,43CEC@68525|delta/epsilon subdivisions,2YTBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S AsmA-like C-terminal region - - - - - - - - - - - - AsmA_1,DUF3971 CMS2_k127_4160709_5 1168067.JAGP01000001_gene1538 7.757e-94 314.0 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,1RMKM@1236|Gammaproteobacteria,462AX@72273|Thiotrichales 72273|Thiotrichales S KR domain - - - - - - - - - - - - adh_short CMS2_k127_4160709_3 1165841.SULAR_02433 3.348e-131 424.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,42MJ0@68525|delta/epsilon subdivisions,2YMCZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Co Zn Cd efflux system component czcD - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux,ZT_dimer CMS2_k127_4160709_7 998674.ATTE01000001_gene3743 1.029e-30 125.0 COG3011@1|root,COG3011@2|Bacteria,1N0YV@1224|Proteobacteria,1S9QH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF393 yuxK - - - - - - - - - - - DUF393 CMS2_k127_4160709_2 1172190.M947_10580 2.633e-174 554.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2YMKF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M ABC-type transport system involved in lipoprotein release permease component lolC - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD CMS2_k127_4160709_0 709032.Sulku_1478 0.0 1223.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2YMV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW CMS2_k127_4176355_15 1537917.JU82_03110 1.007e-65 230.0 COG0778@1|root,COG0778@2|Bacteria,1N95W@1224|Proteobacteria,42RYF@68525|delta/epsilon subdivisions,2YP3N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitroreductase frxA - - - - - - - - - - - Nitroreductase CMS2_k127_4176355_22 1249480.B649_04185 8.132e-48 175.0 2DQ0J@1|root,3348C@2|Bacteria,1NBQ2@1224|Proteobacteria,42UFN@68525|delta/epsilon subdivisions,2YPUT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Chemoreceptor zinc-binding domain - - - - - - - - - - - - CZB CMS2_k127_4176355_20 1537917.JU82_00560 3.863e-51 186.0 COG0421@1|root,COG0421@2|Bacteria,1PD55@1224|Proteobacteria,42UAB@68525|delta/epsilon subdivisions,2YPTY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth CMS2_k127_4176355_14 1249480.B649_00435 8.416e-73 251.0 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,42RI5@68525|delta/epsilon subdivisions,2YP6Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0831 CoaE CMS2_k127_4176355_6 929558.SMGD1_1202 5.001e-106 349.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2YMC6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0566 DAP_epimerase CMS2_k127_4176355_17 1123326.JFBL01000005_gene1181 1.013e-60 218.0 COG2992@1|root,COG2992@2|Bacteria,1RD3U@1224|Proteobacteria,42TDF@68525|delta/epsilon subdivisions,2YP4F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Mannosyl-glycoprotein - - - ko:K03796 - - - - ko00000 - GH73 - Glucosaminidase CMS2_k127_4176355_13 1249480.B649_11510 1.67e-77 272.0 2AIMJ@1|root,3193W@2|Bacteria,1Q1QU@1224|Proteobacteria,42U73@68525|delta/epsilon subdivisions,2YSXF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4176355_27 563040.Saut_2091 1.809e-25 109.0 COG2921@1|root,COG2921@2|Bacteria,1Q61Q@1224|Proteobacteria,42WSH@68525|delta/epsilon subdivisions,2YQB4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0250 family - - - - - - - - - - - - DUF493 CMS2_k127_4176355_11 929558.SMGD1_1154 3.411e-80 269.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,42SNY@68525|delta/epsilon subdivisions,2YNVI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC CMS2_k127_4176355_25 1231241.Mc24_02448 1.401e-37 155.0 COG2199@1|root,COG3706@2|Bacteria,2GDCJ@200918|Thermotogae 200918|Thermotogae T GGDEF domain - - - - - - - - - - - - GGDEF,dCache_1 CMS2_k127_4176355_2 709032.Sulku_2478 6.445e-221 690.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2YN2D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase CMS2_k127_4176355_4 563040.Saut_0096 1.396e-117 392.0 COG1293@1|root,COG1293@2|Bacteria,1R54S@1224|Proteobacteria,42MYG@68525|delta/epsilon subdivisions,2YT8X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K RNA-binding protein homologous to eukaryotic snRNP - - - - - - - - - - - - DUF814,FbpA CMS2_k127_4176355_28 1537917.JU82_00645 7.213e-17 83.0 2ANKR@1|root,31DJY@2|Bacteria,1QAVT@1224|Proteobacteria,42VKM@68525|delta/epsilon subdivisions,2YQB6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4176355_21 1165841.SULAR_03552 5.524e-51 186.0 COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,42RIS@68525|delta/epsilon subdivisions,2YQBI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C CMS2_k127_4176355_8 1165841.SULAR_02138 2.622e-105 349.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,42M0U@68525|delta/epsilon subdivisions,2YNJV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M mechanosensitive ion channel mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix CMS2_k127_4176355_18 929558.SMGD1_1314 1.186e-58 214.0 COG3137@1|root,COG3137@2|Bacteria,1PWI2@1224|Proteobacteria,42W3Z@68525|delta/epsilon subdivisions,2YQX2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 CMS2_k127_4176355_24 563040.Saut_0111 3.921e-40 164.0 COG3137@1|root,COG3137@2|Bacteria,1N2DE@1224|Proteobacteria,42W9S@68525|delta/epsilon subdivisions,2YQI0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 CMS2_k127_4176355_5 1165841.SULAR_08582 3.569e-109 365.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,42P57@68525|delta/epsilon subdivisions,2YMGG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like CMS2_k127_4176355_26 709032.Sulku_0059 1.854e-27 117.0 COG1714@1|root,COG1714@2|Bacteria,1N2TA@1224|Proteobacteria 1224|Proteobacteria S RDD family - - - - - - - - - - - - RDD CMS2_k127_4176355_12 1249480.B649_10435 8.997e-80 271.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,43AK3@68525|delta/epsilon subdivisions,2YT4D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_4176355_7 1537917.JU82_08590 6.944e-106 356.0 COG5002@1|root,COG5002@2|Bacteria,1QZ29@1224|Proteobacteria,43CEG@68525|delta/epsilon subdivisions,2YTC2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA CMS2_k127_4176355_0 929558.SMGD1_0408 3.182e-267 838.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42MXI@68525|delta/epsilon subdivisions,2YRCX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - MCPsignal CMS2_k127_4176355_23 1123326.JFBL01000012_gene142 8.557e-41 157.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2YP5K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT protein-glutamate methylesterase cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest CMS2_k127_4176355_10 929558.SMGD1_0406 3.584e-83 284.0 COG1352@1|root,COG1352@2|Bacteria,1MVP3@1224|Proteobacteria,42PR6@68525|delta/epsilon subdivisions,2YNJY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT methyltransferase - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR CMS2_k127_4176355_1 1165841.SULAR_07380 5.517e-233 739.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,42PUG@68525|delta/epsilon subdivisions,2YN09@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB-dependent copper receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec CMS2_k127_4176355_3 1165841.SULAR_00900 6.018e-157 505.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42QN4@68525|delta/epsilon subdivisions,2YTQA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 CMS2_k127_4176355_9 1537917.JU82_09590 1.012e-85 296.0 COG1373@1|root,COG1373@2|Bacteria,1QP8R@1224|Proteobacteria,42SQ9@68525|delta/epsilon subdivisions,2YPG4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ATPase (AAA - - - ko:K07133 - - - - ko00000 - - - AAA_14 CMS2_k127_4176355_19 1537917.JU82_09585 3.116e-54 191.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2YPG9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 CMS2_k127_4179085_19 929558.SMGD1_1526 1.36e-63 219.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2YP80@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 CMS2_k127_4179085_18 1537917.JU82_02010 1.373e-66 235.0 COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,42RBG@68525|delta/epsilon subdivisions,2YP5T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P carbonic anhydrase cah - 4.2.1.1 ko:K01674 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Carb_anhydrase CMS2_k127_4179085_2 929558.SMGD1_0582 2.192e-302 944.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42MXI@68525|delta/epsilon subdivisions,2YTK8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal CMS2_k127_4179085_4 929558.SMGD1_1528 2.741e-213 673.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2YN87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Abc transporter nikZ - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 CMS2_k127_4179085_13 563040.Saut_1943 2.967e-84 285.0 COG0546@1|root,COG0546@2|Bacteria,1RBMZ@1224|Proteobacteria,42RG3@68525|delta/epsilon subdivisions,2YP44@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Hydrolase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 CMS2_k127_4179085_15 1172190.M947_06035 1.057e-77 262.0 COG1854@1|root,COG1854@2|Bacteria,1MWQF@1224|Proteobacteria,42QP7@68525|delta/epsilon subdivisions,2YNWJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) luxS - 4.4.1.21 ko:K07173 ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 M00609 R01291 RC00069,RC01929 ko00000,ko00001,ko00002,ko01000 - - - LuxS CMS2_k127_4179085_24 1237149.C900_02636 2.114e-24 115.0 COG2274@1|root,COG2274@2|Bacteria,4NFJF@976|Bacteroidetes,47K3G@768503|Cytophagia 976|Bacteroidetes V PFAM ABC transporter - - - - - - - - - - - - ABC_membrane,ABC_tran CMS2_k127_4179085_5 1165841.SULAR_01538 1.675e-122 406.0 COG0845@1|root,COG0845@2|Bacteria,1PZ6R@1224|Proteobacteria 1224|Proteobacteria M COG0845 membrane-fusion protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 CMS2_k127_4179085_6 1165841.SULAR_01543 2.081e-115 387.0 COG1538@1|root,COG1538@2|Bacteria,1MXB2@1224|Proteobacteria 1224|Proteobacteria MU Outer membrane component of multidrug efflux pump - - - - - - - - - - - - OEP CMS2_k127_4179085_12 563040.Saut_1935 6.117e-88 297.0 COG4121@1|root,COG4121@2|Bacteria,1Q8T8@1224|Proteobacteria,42RAP@68525|delta/epsilon subdivisions,2YP3B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_30 CMS2_k127_4179085_23 1449345.JHWC01000005_gene1125 1.663e-24 105.0 COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,42VB5@68525|delta/epsilon subdivisions,2YPVJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S of the cytoplasmic domain of flagellar protein FhlB flhB2 - - ko:K04061 - - - - ko00000,ko02044 - - - Bac_export_2 CMS2_k127_4179085_14 367737.Abu_2211 6.196e-84 282.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2YNYN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H riboflavin synthase alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding CMS2_k127_4179085_17 387093.SUN_0251 1.29e-71 253.0 COG0547@1|root,COG0547@2|Bacteria,1PZRF@1224|Proteobacteria,42R0S@68525|delta/epsilon subdivisions,2YNX2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Glycosyl transferase family, helical bundle domain - - - - - - - - - - - - Glycos_trans_3N,Glycos_transf_3 CMS2_k127_4179085_10 929558.SMGD1_1541 3.647e-90 303.0 COG0790@1|root,COG0790@2|Bacteria,1NY7Z@1224|Proteobacteria,42T5I@68525|delta/epsilon subdivisions,2YPQ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0790 FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - Sel1 CMS2_k127_4179085_21 944547.ABLL_1633 2.24e-58 218.0 COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42R1U@68525|delta/epsilon subdivisions,2YNX6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PAS domain - - - - - - - - - - - - HATPase_c,PAS_9 CMS2_k127_4179085_1 1537917.JU82_01915 1.416e-316 978.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,42KZC@68525|delta/epsilon subdivisions,2YM82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc CMS2_k127_4179085_16 929558.SMGD1_1545 2.981e-76 258.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,42R5N@68525|delta/epsilon subdivisions,2YNX0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N CMS2_k127_4179085_3 929558.SMGD1_1546 1.117e-228 711.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2YMXT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B CMS2_k127_4179085_7 1165841.SULAR_09929 2.586e-102 343.0 COG2857@1|root,COG2857@2|Bacteria,1PX4N@1224|Proteobacteria,42MFF@68525|delta/epsilon subdivisions,2YMBA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C ubiquinol cytochrome c oxidoreductase, cytochrome c1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - iIT341.HP1538 Cytochrom_C,Cytochrom_C1 CMS2_k127_4179085_22 1408473.JHXO01000006_gene1100 8.703e-53 195.0 COG1346@1|root,COG1346@2|Bacteria,4NM6T@976|Bacteroidetes,2FMZ5@200643|Bacteroidia 976|Bacteroidetes M Psort location CytoplasmicMembrane, score 10.00 lrgB - - - - - - - - - - - LrgB CMS2_k127_4179085_25 1211819.CALK01000006_gene2580 9.307e-18 87.0 COG1380@1|root,COG1380@2|Bacteria,1VEN4@1239|Firmicutes,3VSA7@526524|Erysipelotrichia 526524|Erysipelotrichia S LrgA family - - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA CMS2_k127_4179085_11 572480.Arnit_2688 1.366e-89 301.0 COG5285@1|root,COG5285@2|Bacteria,1RC3C@1224|Proteobacteria,42R8R@68525|delta/epsilon subdivisions,2YNW8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - 1.14.11.18 ko:K00477 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - PhyH CMS2_k127_4179085_20 929558.SMGD1_0780 4.709e-59 209.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,42SJ8@68525|delta/epsilon subdivisions,2YNWU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB - - ko:K03664 - - - - ko00000 - - - SmpB CMS2_k127_4179085_8 1172190.M947_06730 1.921e-99 330.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,42RGS@68525|delta/epsilon subdivisions,2YNY5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N CMS2_k127_4179085_9 1537917.JU82_11785 1.669e-97 327.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2YM85@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_N CMS2_k127_4179085_0 709032.Sulku_0508 0.0 1029.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2YMHD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C CMS2_k127_4190139_7 563040.Saut_1625 9.913e-46 165.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2YN91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh CMS2_k127_4190139_8 929558.SMGD1_0720 5.503e-30 124.0 COG4244@1|root,COG4244@2|Bacteria,1PJNV@1224|Proteobacteria,42TI9@68525|delta/epsilon subdivisions,2YQ43@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Membrane - - - - - - - - - - - - - CMS2_k127_4190139_2 326298.Suden_0498 2.164e-131 419.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M6H@68525|delta/epsilon subdivisions,2YNC6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S ferredoxin - - - - - - - - - - - - Fer4_11,Fer4_4 CMS2_k127_4190139_1 1537917.JU82_09720 1.884e-132 428.0 COG3301@1|root,COG3301@2|Bacteria,1QSRQ@1224|Proteobacteria,42PAY@68525|delta/epsilon subdivisions,2YN5Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD CMS2_k127_4190139_0 929558.SMGD1_0713 0.0 2020.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42MWW@68525|delta/epsilon subdivisions,2YMMH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding CMS2_k127_4190139_6 929558.SMGD1_1157 1.883e-49 182.0 COG3439@1|root,COG3439@2|Bacteria,1REDZ@1224|Proteobacteria,42T1V@68525|delta/epsilon subdivisions,2YPRR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 CMS2_k127_4190139_4 326298.Suden_1494 2.141e-87 292.0 COG3381@1|root,COG3381@2|Bacteria,1N4MX@1224|Proteobacteria,42RVB@68525|delta/epsilon subdivisions,2YP5X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S component of anaerobic - - - - - - - - - - - - Nitrate_red_del CMS2_k127_4190139_5 709032.Sulku_0644 3.347e-70 245.0 COG1143@1|root,COG2768@1|root,COG1143@2|Bacteria,COG2768@2|Bacteria,1N7HT@1224|Proteobacteria 1224|Proteobacteria C 4fe-4s ferredoxin, iron-sulfur binding - - - - - - - - - - - - Fer4 CMS2_k127_4191843_5 709032.Sulku_1547 1.818e-70 244.0 COG3864@1|root,COG3864@2|Bacteria,1Q995@1224|Proteobacteria,42YHV@68525|delta/epsilon subdivisions,2YRK9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative metallopeptidase domain - - - - - - - - - - - - DUF2201,DUF2201_N CMS2_k127_4191843_2 1249480.B649_06870 4.691e-171 541.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42VWM@68525|delta/epsilon subdivisions,2YQKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0714 MoxR-like - - - - - - - - - - - - AAA_5 CMS2_k127_4191843_7 1537917.JU82_00980 2.256e-36 140.0 2BR28@1|root,32K00@2|Bacteria,1Q2JJ@1224|Proteobacteria,42VUT@68525|delta/epsilon subdivisions,2YQF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S NifQ - - - ko:K15790 - - - - ko00000 - - - NifQ CMS2_k127_4191843_1 709032.Sulku_1316 4.043e-214 671.0 COG0426@1|root,COG0426@2|Bacteria,1NDXY@1224|Proteobacteria,42N11@68525|delta/epsilon subdivisions,2YNA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Metallo-beta-lactamase superfamily - - 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B CMS2_k127_4191843_8 990073.ATHU01000001_gene1759 8.348e-31 124.0 COG0633@1|root,COG0633@2|Bacteria,1NJF0@1224|Proteobacteria 1224|Proteobacteria C Ferredoxin - - - - - - - - - - - - Fer2 CMS2_k127_4191843_9 709032.Sulku_1315 1.036e-22 101.0 2AK69@1|root,31AW9@2|Bacteria,1Q6BQ@1224|Proteobacteria,432TB@68525|delta/epsilon subdivisions,2YST5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4191843_3 1537917.JU82_00990 1.983e-81 286.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,42MWR@68525|delta/epsilon subdivisions,2YNCN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C TIGRFAM SagB-type dehydrogenase domain - - - - - - - - - - - - Nitroreductase CMS2_k127_4191843_6 709032.Sulku_1312 3.256e-57 202.0 COG0666@1|root,COG0666@2|Bacteria,1Q4NQ@1224|Proteobacteria,42VS5@68525|delta/epsilon subdivisions,2YQIE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Ankyrin repeat - - - - - - - - - - - - Ank_4 CMS2_k127_4191843_4 709032.Sulku_1311 2.042e-80 271.0 COG2077@1|root,COG2077@2|Bacteria,1Q5WV@1224|Proteobacteria,431ZJ@68525|delta/epsilon subdivisions,2YSAN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O AhpC/TSA family - - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin CMS2_k127_4191843_0 1249480.B649_06915 1.373e-238 743.0 COG1956@1|root,COG3604@1|root,COG1956@2|Bacteria,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2YNEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF_2,HTH_8,Sigma54_activat CMS2_k127_4202387_0 1150621.SMUL_2950 0.0 1733.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,42P49@68525|delta/epsilon subdivisions,2YNRZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EI Allophanate hydrolase subunit 1 - - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D CMS2_k127_4202387_1 317025.Tcr_1803 5.358e-47 170.0 COG0491@1|root,COG0491@2|Bacteria,1PHBX@1224|Proteobacteria,1S357@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metallo-beta-lactamase superfamily - - 3.1.1.81 ko:K13075 ko02024,map02024 - R08970 RC00713 ko00000,ko00001,ko01000 - - - Lactamase_B CMS2_k127_4234886_0 1165841.SULAR_09659 0.0 1391.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2YMJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS2_k127_4234886_1 1165841.SULAR_09654 8.918e-53 187.0 COG5615@1|root,COG5615@2|Bacteria,1Q1KK@1224|Proteobacteria,42TX3@68525|delta/epsilon subdivisions,2YPV4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S integral membrane protein - - - - - - - - - - - - - CMS2_k127_426117_1 338966.Ppro_0100 1.863e-15 85.0 COG5397@1|root,COG5397@2|Bacteria,1RAQX@1224|Proteobacteria,42R41@68525|delta/epsilon subdivisions,2WN8A@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Nucleotidyltransferase - - - - - - - - - - - - NTP_transf_8 CMS2_k127_426117_3 1123511.KB905887_gene304 1.128e-06 54.0 arCOG07173@1|root,32VRD@2|Bacteria,1VAYY@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - CMS2_k127_426117_2 386456.JQKN01000001_gene1914 9.189e-07 52.0 COG0642@1|root,arCOG02349@1|root,arCOG02350@1|root,arCOG02352@1|root,arCOG06712@1|root,arCOG02349@2157|Archaea,arCOG02350@2157|Archaea,arCOG02352@2157|Archaea,arCOG02358@2157|Archaea,arCOG06712@2157|Archaea 2157|Archaea T PAS domain - - - - - - - - - - - - GAF,GAF_2,GAF_3,HATPase_c,HisKA,HisKA_4TM,PAS,PAS_3,PAS_4,PAS_9 CMS2_k127_426117_0 227377.CBU_0724 1.136e-82 285.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1JEXQ@118969|Legionellales 118969|Legionellales L Helix-turn-helix domain - - - - - - - - - - - - HTH_38,rve CMS2_k127_426117_4 237368.SCABRO_00680 1.43e-05 51.0 2C4PV@1|root,34CH5@2|Bacteria,2J45E@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - CMS2_k127_4262524_1 631454.N177_0761 3.947e-18 87.0 2ER3W@1|root,33IPG@2|Bacteria,1NP42@1224|Proteobacteria,2UM3T@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4262524_0 309807.SRU_2866 2.03e-31 128.0 2E2RH@1|root,32XTZ@2|Bacteria,4NTV2@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_4273954_0 1249480.B649_06845 5.213e-82 278.0 2BV3K@1|root,32QGM@2|Bacteria,1Q4NH@1224|Proteobacteria,42ZI1@68525|delta/epsilon subdivisions,2YRN8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4273954_2 1249480.B649_06835 4.729e-39 150.0 COG1393@1|root,COG1393@2|Bacteria,1MZ7Z@1224|Proteobacteria,42VII@68525|delta/epsilon subdivisions,2YSA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the ArsC family - - - - - - - - - - - - ArsC CMS2_k127_4273954_1 1165841.SULAR_01968 1.487e-41 154.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,43AMB@68525|delta/epsilon subdivisions,2YT1W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg CMS2_k127_4301506_13 553220.CAMGR0001_0112 1.495e-59 211.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2YNU1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N CMS2_k127_4301506_7 367737.Abu_0166 1.122e-154 501.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2YN5S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N CMS2_k127_4301506_6 563040.Saut_2108 8.639e-157 503.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,42P59@68525|delta/epsilon subdivisions,2YMPJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0324 family - - - - - - - - - - - - Cons_hypoth698 CMS2_k127_4301506_3 326298.Suden_2033 2.182e-192 612.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2YMTY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Mg chelatase-related protein comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C CMS2_k127_4301506_12 709032.Sulku_2528 3.165e-69 238.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,42RFN@68525|delta/epsilon subdivisions,2YP6C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase CMS2_k127_4301506_8 929558.SMGD1_1193 3.214e-129 421.0 COG2199@1|root,COG2199@2|Bacteria,1QZ2R@1224|Proteobacteria,43CET@68525|delta/epsilon subdivisions,2YTCA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF CMS2_k127_4301506_10 572480.Arnit_2419 1.224e-102 336.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2YMBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease CMS2_k127_4301506_5 1537917.JU82_05135 1.201e-183 583.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2YMFZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N CMS2_k127_4301506_9 563040.Saut_2146 3.891e-103 338.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,42N1U@68525|delta/epsilon subdivisions,2YMVV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F GTP cyclohydrolase folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0928 GTP_cyclohydroI CMS2_k127_4301506_1 1249480.B649_11695 1.557e-213 669.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,42M0K@68525|delta/epsilon subdivisions,2YMJX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU ATP synthase fliI - 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab CMS2_k127_4301506_2 709032.Sulku_2522 6.612e-209 654.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2YM81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Cysteine desulfurase iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 CMS2_k127_4301506_4 326298.Suden_2007 4.892e-184 578.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2YMXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins iscU - - ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N CMS2_k127_4301506_11 709032.Sulku_1100 1.385e-90 305.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42RH7@68525|delta/epsilon subdivisions 1224|Proteobacteria N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA CMS2_k127_4301506_0 709032.Sulku_2520 5.662e-216 680.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2YNM1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T ATPase related to phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH CMS2_k127_4305665_18 1034347.CAHJ01000084_gene1359 3.704e-07 53.0 2A61F@1|root,30UTS@2|Bacteria,1UB8J@1239|Firmicutes,4IMMA@91061|Bacilli,1ZKEM@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - CMS2_k127_4305665_6 1208321.D104_04585 3.699e-81 283.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1XITI@135619|Oceanospirillales 135619|Oceanospirillales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport CMS2_k127_4305665_5 563040.Saut_1582 4.678e-121 393.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2YMI2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - ko:K02034,ko:K12370 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N CMS2_k127_4305665_1 1249480.B649_03465 1.193e-210 671.0 COG1256@1|root,COG1749@1|root,COG1256@2|Bacteria,COG1749@2|Bacteria,1MV2M@1224|Proteobacteria,42PBN@68525|delta/epsilon subdivisions,2YMGR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C CMS2_k127_4305665_10 709032.Sulku_0699 5.157e-49 179.0 2AIM0@1|root,32I9V@2|Bacteria,1Q1S6@1224|Proteobacteria,42U9Z@68525|delta/epsilon subdivisions,2YPXP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4305665_16 326298.Suden_0564 2.302e-09 60.0 2AK6X@1|root,31AX3@2|Bacteria,1Q6DV@1224|Proteobacteria,432YY@68525|delta/epsilon subdivisions,2YSIQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Anti-sigma-28 factor, FlgM - - - - - - - - - - - - FlgM CMS2_k127_4305665_14 563040.Saut_1586 2.799e-23 104.0 COG3951@1|root,COG3951@2|Bacteria,1Q5W9@1224|Proteobacteria,42UQG@68525|delta/epsilon subdivisions,2YPWJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MNO Rod binding protein flgJ - - - - - - - - - - - Rod-binding CMS2_k127_4305665_3 563040.Saut_1587 1.782e-144 465.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,42MAU@68525|delta/epsilon subdivisions,2YMBU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI CMS2_k127_4305665_8 563040.Saut_1588 4.609e-65 227.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2YP4X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L methyltransferase rsmD - - - - - - - - - - - Cons_hypoth95 CMS2_k127_4305665_13 326298.Suden_0560 4.215e-31 126.0 2B10Q@1|root,319PM@2|Bacteria,1Q3G4@1224|Proteobacteria,42X9K@68525|delta/epsilon subdivisions,2YQYY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4305665_7 326298.Suden_0559 3.194e-66 233.0 COG0847@1|root,COG0847@2|Bacteria,1RGGD@1224|Proteobacteria,42ZIP@68525|delta/epsilon subdivisions,2YRQP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0847 DNA polymerase III epsilon subunit and related 3'-5' - - 2.7.7.7 ko:K02342,ko:K10857 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T CMS2_k127_4305665_11 929558.SMGD1_1925 7.397e-45 166.0 2A067@1|root,30N97@2|Bacteria,1Q1X8@1224|Proteobacteria,42UM9@68525|delta/epsilon subdivisions,2YPYZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4305665_2 709032.Sulku_0681 1.135e-190 603.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2YMEB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase CMS2_k127_4305665_9 1249480.B649_08915 5.906e-54 191.0 COG0789@1|root,COG0789@2|Bacteria,1N948@1224|Proteobacteria,42SGY@68525|delta/epsilon subdivisions,2YPH4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator hspR - - ko:K13640 - - - - ko00000,ko03000 - - - MerR_1 CMS2_k127_4305665_4 1249480.B649_08920 8.888e-134 431.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2YMSY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Co-chaperone-curved DNA binding protein A cbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C CMS2_k127_4305665_0 709032.Sulku_1867 8.576e-279 863.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2YN13@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS CMS2_k127_4314364_4 572480.Arnit_1759 9.167e-83 290.0 COG3673@1|root,COG3673@2|Bacteria,1QV8K@1224|Proteobacteria 1224|Proteobacteria S Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - - - - - - - - - - DUF2235 CMS2_k127_4314364_1 563040.Saut_0616 1.077e-174 557.0 COG5002@1|root,COG5002@2|Bacteria,1QUJ9@1224|Proteobacteria,42MEB@68525|delta/epsilon subdivisions,2YMXI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA CMS2_k127_4314364_7 1172190.M947_02060 2.882e-50 186.0 COG0745@1|root,COG0745@2|Bacteria,1Q456@1224|Proteobacteria,42RZX@68525|delta/epsilon subdivisions,2YP60@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_4314364_2 563040.Saut_0618 9.547e-140 454.0 COG0840@1|root,COG0840@2|Bacteria,1QZ1R@1224|Proteobacteria,42SSJ@68525|delta/epsilon subdivisions,2YPF5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT transmembrane signaling receptor activity - - - - - - - - - - - - dCache_3 CMS2_k127_4314364_0 563040.Saut_0620 3.866e-211 664.0 COG3746@1|root,COG3746@2|Bacteria,1R8Q0@1224|Proteobacteria 1224|Proteobacteria P phosphate-selective porin O and P - - - - - - - - - - - - Porin_O_P CMS2_k127_4314364_6 563040.Saut_0619 5.321e-56 200.0 COG1416@1|root,COG1416@2|Bacteria,1MZ46@1224|Proteobacteria 1224|Proteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE CMS2_k127_4314364_5 326298.Suden_0267 3.117e-56 199.0 COG1416@1|root,COG1416@2|Bacteria,1NI85@1224|Proteobacteria,42TA0@68525|delta/epsilon subdivisions,2YPH8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE CMS2_k127_4314364_8 563040.Saut_0998 1.141e-28 121.0 COG2143@1|root,COG2143@2|Bacteria,1NEN3@1224|Proteobacteria,42SXU@68525|delta/epsilon subdivisions,2YPR0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7 CMS2_k127_4314364_3 563040.Saut_0997 1.845e-97 325.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42R7E@68525|delta/epsilon subdivisions,2YNXU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,Omptin CMS2_k127_4322596_1 1537917.JU82_04990 4.844e-84 278.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,42MMI@68525|delta/epsilon subdivisions,2YNPZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase protein alpha chain - - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro CMS2_k127_4322596_0 1249480.B649_06530 1.674e-303 934.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,42MNG@68525|delta/epsilon subdivisions,2YNM4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation - - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro CMS2_k127_4322596_2 387093.SUN_1621 1.178e-19 91.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,42NTK@68525|delta/epsilon subdivisions,2YNFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 CMS2_k127_4328252_1 326298.Suden_1562 1.724e-95 317.0 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,42MYK@68525|delta/epsilon subdivisions,2YMMB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG CMS2_k127_4328252_0 709032.Sulku_0374 2.561e-169 535.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2YMPY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N CMS2_k127_4328252_2 1249480.B649_01705 3.728e-56 196.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2YMAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C CMS2_k127_4358465_8 944547.ABLL_0894 1.322e-49 179.0 COG0419@1|root,COG0419@2|Bacteria,1MVTQ@1224|Proteobacteria,42NVV@68525|delta/epsilon subdivisions,2YRDU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Putative exonuclease SbcCD, C subunit - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,SbcCD_C CMS2_k127_4358465_6 1172190.M947_01725 9.476e-162 519.0 COG0420@1|root,COG0420@2|Bacteria,1MVV6@1224|Proteobacteria,42PFX@68525|delta/epsilon subdivisions,2YRGY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,SbcD_C CMS2_k127_4358465_9 1249480.B649_06065 6.253e-11 67.0 COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,42M9T@68525|delta/epsilon subdivisions,2YNP9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the 'phage' integrase family - - - ko:K14059 - - - - ko00000 - - - Arm-DNA-bind_2,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase CMS2_k127_4358465_2 945713.IALB_1501 2.585e-226 716.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria 2|Bacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin korA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N CMS2_k127_4358465_7 518766.Rmar_0336 7.946e-123 402.0 COG1013@1|root,COG1013@2|Bacteria,4NIE0@976|Bacteroidetes,1FIT9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain oorB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C CMS2_k127_4358465_10 1537917.JU82_10305 1.741e-06 53.0 COG2608@1|root,COG2608@2|Bacteria,1N81B@1224|Proteobacteria,42VKI@68525|delta/epsilon subdivisions,2YQD5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Heavy-metal-associated domain - - - - - - - - - - - - HMA CMS2_k127_4358465_5 326298.Suden_1051 8.795e-164 517.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2YMZR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA CMS2_k127_4358465_3 929558.SMGD1_2656 6.129e-223 694.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2YMJ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA CMS2_k127_4358465_0 563040.Saut_1115 1.171e-265 822.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2YTA6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 CMS2_k127_4358465_4 563040.Saut_1114 3.374e-170 538.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2YMR0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N CMS2_k127_4358465_1 1165841.SULAR_01515 1.12e-232 724.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2YMT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH CMS2_k127_4363551_1 326298.Suden_1755 1.798e-53 194.0 COG1057@1|root,COG1057@2|Bacteria,1NG4J@1224|Proteobacteria,42P0F@68525|delta/epsilon subdivisions,2YMQR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like,RsfS CMS2_k127_4363551_2 1537917.JU82_10985 1.893e-42 158.0 COG0799@1|root,COG0799@2|Bacteria,1RCJN@1224|Proteobacteria,42TWB@68525|delta/epsilon subdivisions,2YPU4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS CMS2_k127_4363551_0 563040.Saut_0407 5.072e-200 630.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2YMHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d CMS2_k127_4370956_2 572480.Arnit_1741 9.921e-95 329.0 COG3515@1|root,COG3515@2|Bacteria,1RC37@1224|Proteobacteria,43ACE@68525|delta/epsilon subdivisions 1224|Proteobacteria S Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ - - - ko:K11910 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - ImpA_N,T6SS_VasJ CMS2_k127_4370956_3 572480.Arnit_1742 9.864e-62 216.0 COG3516@1|root,COG3516@2|Bacteria,1RBNB@1224|Proteobacteria,42S55@68525|delta/epsilon subdivisions,2YP5H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Type VI secretion tssB - - ko:K11901 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_VipA CMS2_k127_4370956_0 572480.Arnit_1743 2.124e-270 837.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,42M4A@68525|delta/epsilon subdivisions,2YNDF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S type VI secretion protein tssC - - ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB CMS2_k127_4370956_5 572480.Arnit_1744 1.259e-42 160.0 COG3518@1|root,COG3518@2|Bacteria,1N885@1224|Proteobacteria,42WTJ@68525|delta/epsilon subdivisions 1224|Proteobacteria S TIGRFAM Type VI secretion system, lysozyme-related tssE2 - - ko:K11905 - M00334 - - ko00000,ko00002,ko02044 - - - GPW_gp25 CMS2_k127_4370956_1 572480.Arnit_1745 3.641e-196 625.0 COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,42PZ8@68525|delta/epsilon subdivisions,2YNUC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Type VI secretion vasA - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF CMS2_k127_437785_5 1249480.B649_11220 2.562e-93 308.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2YMWB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 CMS2_k127_437785_8 1249480.B649_11215 2.087e-62 224.0 COG0760@1|root,COG0760@2|Bacteria,1N20M@1224|Proteobacteria,42SXW@68525|delta/epsilon subdivisions,2YPHS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - - - - - - - - - - Rotamase_2,SurA_N,SurA_N_3 CMS2_k127_437785_2 563040.Saut_2031 5.508e-232 728.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2YMCW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iIT341.HP0476 tRNA-synt_1c CMS2_k127_437785_3 929558.SMGD1_1003 7.982e-188 595.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2YMJJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C malic enzyme mez - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic CMS2_k127_437785_1 326298.Suden_1506 3.329e-246 766.0 COG0579@1|root,COG0579@2|Bacteria,1MUCC@1224|Proteobacteria,42M2Q@68525|delta/epsilon subdivisions,2YMYG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Malate quinone- oxidoreductase mqo GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.5.4 ko:K00116 ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R00360,R00361,R01257 RC00031 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0086 Mqo CMS2_k127_437785_0 929558.SMGD1_0424 0.0 1348.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,42M05@68525|delta/epsilon subdivisions,2YNMZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Bacterial NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH CMS2_k127_437785_6 1172190.M947_07485 2.26e-70 244.0 COG1427@1|root,COG1427@2|Bacteria,1RCS0@1224|Proteobacteria,42MJZ@68525|delta/epsilon subdivisions,2YN8T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnA - 4.2.1.151 ko:K11782 ko00130,ko01110,map00130,map01110 - R10666 RC03232 ko00000,ko00001,ko01000 - - - VitK2_biosynth CMS2_k127_437785_11 273068.TTE1100 2.939e-20 100.0 COG0784@1|root,COG2199@1|root,COG3290@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,42FTQ@68295|Thermoanaerobacterales 186801|Clostridia T Response regulator receiver - - - - - - - - - - - - FIST,FIST_C,GGDEF,PAS,PAS_8,PAS_9,Response_reg CMS2_k127_437785_10 944479.JQLX01000014_gene1603 1.048e-21 104.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,43AWB@68525|delta/epsilon subdivisions,2X6AJ@28221|Deltaproteobacteria,2M6DI@213113|Desulfurellales 28221|Deltaproteobacteria T diguanylate cyclase - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF CMS2_k127_437785_9 1249480.B649_11195 4.689e-25 107.0 COG1977@1|root,COG1977@2|Bacteria,1Q2EI@1224|Proteobacteria,42VIE@68525|delta/epsilon subdivisions,2YQ69@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin converting factor moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS CMS2_k127_437785_7 563040.Saut_0207 8.481e-70 239.0 COG0314@1|root,COG0314@2|Bacteria,1Q97D@1224|Proteobacteria,42REX@68525|delta/epsilon subdivisions,2YP4E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin converting factor moaE - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE CMS2_k127_437785_4 709032.Sulku_2364 1.411e-148 480.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2YMQH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin biosynthesis moeA2 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N CMS2_k127_4463851_12 929558.SMGD1_0575 7.04e-34 132.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2YPTZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K 'Cold-shock' DNA-binding domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS2_k127_4463851_9 1537917.JU82_03485 2.642e-141 455.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2YND0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK CMS2_k127_4463851_16 709032.Sulku_1881 2.976e-05 46.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2YND0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK CMS2_k127_4463851_15 1121013.P873_01780 1.809e-16 87.0 2CAR9@1|root,333CX@2|Bacteria,1NCNC@1224|Proteobacteria,1SF0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4463851_1 1172190.M947_07965 1.9e-322 1007.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0474 Cation transport ATPase - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 CMS2_k127_4463851_14 563040.Saut_0560 2.56e-25 107.0 COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,42X2R@68525|delta/epsilon subdivisions,2YSI9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding CMS2_k127_4463851_8 563040.Saut_0559 6.979e-153 492.0 COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,42PEC@68525|delta/epsilon subdivisions,2YRB8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl CMS2_k127_4463851_6 879212.DespoDRAFT_00219 3.776e-172 544.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42MBM@68525|delta/epsilon subdivisions,2WJKG@28221|Deltaproteobacteria,2MMK7@213118|Desulfobacterales 28221|Deltaproteobacteria C Transketolase, pyrimidine binding domain pdhB - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2753 Transket_pyr,Transketolase_C CMS2_k127_4463851_7 879212.DespoDRAFT_00220 2.074e-154 492.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2MMYC@213118|Desulfobacterales 28221|Deltaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh CMS2_k127_4463851_2 387093.SUN_0967 3.289e-305 942.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2YR82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I AMP-binding enzyme C-terminal domain - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C CMS2_k127_4463851_11 572480.Arnit_2603 2.918e-45 174.0 COG0095@1|root,COG0095@2|Bacteria,1RI3T@1224|Proteobacteria,42SQP@68525|delta/epsilon subdivisions 1224|Proteobacteria H PFAM biotin lipoate A B protein ligase lplA - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB CMS2_k127_4463851_10 387093.SUN_0965 1.694e-119 390.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,42P2E@68525|delta/epsilon subdivisions,2YNPW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - Radical_SAM CMS2_k127_4463851_5 563040.Saut_0554 6.357e-174 556.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2YTQ6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim CMS2_k127_4463851_3 635013.TherJR_2223 5.053e-304 962.0 COG1470@1|root,COG5276@1|root,COG1470@2|Bacteria,COG5276@2|Bacteria 2|Bacteria S cell adhesion involved in biofilm formation - - - ko:K12287 - - - - ko00000,ko02044 - - - Big_5,CarboxypepD_reg,DUF1566,He_PIG,LVIVD,SLH CMS2_k127_4463851_0 1165841.SULAR_03597 0.0 1397.0 COG1251@1|root,COG1740@1|root,COG1251@2|Bacteria,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42PSD@68525|delta/epsilon subdivisions,2YNBA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C hydrogenase (NiFe) small subunit HydA - - 1.12.5.1 ko:K05927 - - - - ko00000,ko01000 - - - Fer2_BFD,NiFe_hyd_SSU_C,Oxidored_q6,Pyr_redox_2 CMS2_k127_4463851_4 1537917.JU82_08440 6.161e-296 916.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2YM8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.5.1 ko:K05922 - - - - ko00000,ko01000 - - - NiFeSe_Hases CMS2_k127_4463851_13 1165841.SULAR_02928 1.48e-33 131.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2YP5U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C hydrogenase maturation protease hydD - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI CMS2_k127_4494720_0 563040.Saut_0294 8.996e-113 377.0 COG0667@1|root,COG0667@2|Bacteria,1RHYD@1224|Proteobacteria,42SEU@68525|delta/epsilon subdivisions,2YT8N@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red CMS2_k127_4494720_1 326298.Suden_0328 5.089e-52 185.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2YPKU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 CMS2_k127_4494720_2 929558.SMGD1_0936 5.308e-29 116.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2YM93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L CMS2_k127_4512952_2 929558.SMGD1_2643 1.09e-174 552.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,42M43@68525|delta/epsilon subdivisions,2YM8G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the aconitase IPM isomerase family acnB GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0045333,GO:0046395,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:0097159,GO:1901363,GO:1901575 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N CMS2_k127_4512952_0 709032.Sulku_1186 1.985e-296 927.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2YMTD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the FtsK SpoIIIE SftA family ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma CMS2_k127_4512952_1 1249480.B649_05085 2.32e-201 649.0 COG1344@1|root,COG1344@2|Bacteria,1N1QF@1224|Proteobacteria,42PDD@68525|delta/epsilon subdivisions,2YMYD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N CMS2_k127_4512952_3 1548153.LR59_05860 1.305e-18 90.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,42VDU@68525|delta/epsilon subdivisions,2YPKB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the bacterial histone-like protein family hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding CMS2_k127_4542372_0 7668.SPU_007167-tr 7.474e-26 126.0 KOG1075@1|root,KOG1075@2759|Eukaryota,39Y6T@33154|Opisthokonta,3BEGN@33208|Metazoa,3CZ7K@33213|Bilateria 33208|Metazoa G positive regulation of TOR signaling - - - - - - - - - - - - Exo_endo_phos_2,RVT_1 CMS2_k127_4574030_0 563040.Saut_0398 7.074e-128 419.0 2C99Z@1|root,2Z9YV@2|Bacteria,1N0B7@1224|Proteobacteria,42P3M@68525|delta/epsilon subdivisions,2YMWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3373) - - - - - - - - - - - - DUF3373 CMS2_k127_4602986_5 929558.SMGD1_0358 2.708e-45 168.0 29BJD@1|root,2ZYHR@2|Bacteria,1Q9EC@1224|Proteobacteria,42SGC@68525|delta/epsilon subdivisions,2YPYW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterized lipoprotein - - - ko:K07286 - - - - ko00000 - - - Lipoprotein_16 CMS2_k127_4602986_1 929558.SMGD1_1846 1.236e-224 719.0 COG0457@1|root,COG0457@2|Bacteria,1QV15@1224|Proteobacteria,42NKI@68525|delta/epsilon subdivisions,2YMKG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG0457 FOG TPR repeat pflB - - - - - - - - - - - TPR_16,TPR_2,TPR_6,TPR_8 CMS2_k127_4602986_3 709032.Sulku_1891 4.408e-79 270.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2YMTK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf CMS2_k127_4602986_6 1367491.BN865_10120 8.467e-11 70.0 COG0688@1|root,COG0688@2|Bacteria,1P7K4@1224|Proteobacteria,42TG5@68525|delta/epsilon subdivisions,2YPVS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I phosphatidylserine - - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase CMS2_k127_4602986_0 1537917.JU82_07085 2.73e-308 956.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2YMMU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 CMS2_k127_4602986_2 709032.Sulku_1894 1.632e-102 341.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2YNZK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA CMS2_k127_4602986_4 709032.Sulku_1895 9.796e-67 228.0 COG2199@1|root,COG3706@2|Bacteria,1N0N3@1224|Proteobacteria,43E7J@68525|delta/epsilon subdivisions,2YTC4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Chemotaxis protein cheY - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg CMS2_k127_4607983_0 929558.SMGD1_0873 1.392e-265 821.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2YMAY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Glycolate oxidase subunit glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 CMS2_k127_4607983_5 326298.Suden_0373 3.08e-80 278.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,42MBW@68525|delta/epsilon subdivisions,2YMVQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ribonuclease BN rbn - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB CMS2_k127_4607983_4 1123326.JFBL01000001_gene1411 1.922e-86 302.0 COG0658@1|root,COG0658@2|Bacteria,1PY6P@1224|Proteobacteria,42NU2@68525|delta/epsilon subdivisions,2YME0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Competence protein comE - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence CMS2_k127_4607983_1 563040.Saut_0341 5.636e-222 696.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2YM91@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C CMS2_k127_4607983_2 1537917.JU82_02560 3.313e-194 609.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,42M3V@68525|delta/epsilon subdivisions,2YMJP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0625 GcpE CMS2_k127_4607983_3 326298.Suden_0368 7.739e-142 457.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2YMIP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C CMS2_k127_4617304_1 1165841.SULAR_01918 9.405e-81 271.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,42N4S@68525|delta/epsilon subdivisions 1224|Proteobacteria S PFAM amine oxidase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 CMS2_k127_4617304_2 1165841.SULAR_01913 5.326e-57 203.0 COG3040@1|root,COG3040@2|Bacteria,1Q522@1224|Proteobacteria,430CX@68525|delta/epsilon subdivisions,2YS4M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Lipocalin-like domain - - - - - - - - - - - - Lipocalin_2 CMS2_k127_4617304_3 1452718.JBOY01000028_gene110 1.167e-10 68.0 COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,1S8Y4@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Protein-S-isoprenylcysteine methyltransferase - - - - - - - - - - - - PEMT CMS2_k127_4617304_0 1165841.SULAR_01903 1.819e-101 342.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,42NJV@68525|delta/epsilon subdivisions,2YRBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 CMS2_k127_4661624_19 563040.Saut_0661 4.47e-12 67.0 COG0731@1|root,COG0731@2|Bacteria,1QG36@1224|Proteobacteria,42M82@68525|delta/epsilon subdivisions,2YN42@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM CMS2_k127_4661624_9 1172190.M947_01760 8.722e-59 205.0 COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,42SBR@68525|delta/epsilon subdivisions,2YPGJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P PFAM DsrE family protein - - - ko:K06039 - - - - ko00000 - - - DrsE CMS2_k127_4661624_10 1249480.B649_02025 2.713e-55 197.0 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,42T86@68525|delta/epsilon subdivisions,2YPHR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese CMS2_k127_4661624_17 224324.aq_598 1.169e-14 80.0 COG3439@1|root,COG3439@2|Bacteria 2|Bacteria D Domain of unknown function DUF302 - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Beta-lactamase,DUF302 CMS2_k127_4661624_8 563040.Saut_1895 3.561e-63 218.0 COG0640@1|root,COG0640@2|Bacteria,1Q4XP@1224|Proteobacteria,4303J@68525|delta/epsilon subdivisions,2YRVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20 CMS2_k127_4661624_0 1165841.SULAR_01210 3.318e-283 877.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42PNH@68525|delta/epsilon subdivisions,2YRFG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N CMS2_k127_4661624_5 1304888.ATWF01000001_gene932 2.294e-97 330.0 COG3437@1|root,COG3437@2|Bacteria,2GFDI@200930|Deferribacteres 200930|Deferribacteres T HD domain - - - - - - - - - - - - HD,Response_reg CMS2_k127_4661624_4 349521.HCH_00794 1.004e-115 400.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XNGF@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg,dCache_1 CMS2_k127_4661624_18 929558.SMGD1_2423 3.753e-13 70.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43AD8@68525|delta/epsilon subdivisions 1224|Proteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,DUF3365,HATPase_c,HisKA,NMT1,PAS,PAS_3,PAS_9,PilJ,Response_reg,SBP_bac_3 CMS2_k127_4661624_3 1165841.SULAR_01943 1.354e-118 386.0 COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2YNXM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Epimerase - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase CMS2_k127_4661624_11 929558.SMGD1_1567 2.921e-51 184.0 COG1331@1|root,COG1331@2|Bacteria,1PFA6@1224|Proteobacteria,430WR@68525|delta/epsilon subdivisions,2YRYY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredoxin_7 CMS2_k127_4661624_14 1172190.M947_08995 3.056e-44 166.0 COG1331@1|root,COG1331@2|Bacteria,1QZ2A@1224|Proteobacteria,42VGW@68525|delta/epsilon subdivisions,2YQEQ@29547|Epsilonproteobacteria 1224|Proteobacteria O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH,Thioredoxin_7 CMS2_k127_4661624_6 1165841.SULAR_03108 5.08e-86 293.0 COG0561@1|root,COG0561@2|Bacteria,1Q5G6@1224|Proteobacteria,42R7D@68525|delta/epsilon subdivisions,2YP2E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S of the HAD superfamily - - - - - - - - - - - - Hydrolase_3 CMS2_k127_4661624_2 563040.Saut_0377 8.438e-139 447.0 COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,42Q1Y@68525|delta/epsilon subdivisions,2YNR2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the glutaminase family glsA - 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 - R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Glutaminase CMS2_k127_4661624_7 1165841.SULAR_09754 2.301e-71 250.0 COG3751@1|root,COG3751@2|Bacteria,1Q4MK@1224|Proteobacteria,42ZFP@68525|delta/epsilon subdivisions,2YRNS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Prolyl 4-hydroxylase alpha subunit homologues. - - - ko:K07394 - - - - ko00000 - - - 2OG-FeII_Oxy_3 CMS2_k127_4661624_13 929558.SMGD1_2838 5.671e-46 173.0 COG0513@1|root,COG0513@2|Bacteria 2|Bacteria L helicase activity - - 3.6.4.13 ko:K05592,ko:K06877,ko:K07462,ko:K11927 ko03018,ko03410,ko03430,ko03440,map03018,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03400 - - - DEAD,DbpA,Helicase_C,Helicase_C_2,Mrr_cat_2,N6_Mtase,ResIII CMS2_k127_4661624_1 929558.SMGD1_2771 2.879e-176 572.0 COG5001@1|root,COG5001@2|Bacteria,1R4H0@1224|Proteobacteria,43CII@68525|delta/epsilon subdivisions,2YTD5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF CMS2_k127_4661624_20 1249480.B649_05340 1.568e-08 63.0 2AJ5J@1|root,319Q6@2|Bacteria,1Q3I6@1224|Proteobacteria,42XD0@68525|delta/epsilon subdivisions,2YR0I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4661624_12 929558.SMGD1_2769 6.769e-49 180.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42WJ0@68525|delta/epsilon subdivisions,2YQJR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P PFAM TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec CMS2_k127_4684058_2 1249480.B649_01180 3.09e-93 308.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2YMNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh CMS2_k127_4684058_1 1249480.B649_01185 3.027e-108 353.0 COG1143@1|root,COG1143@2|Bacteria,1MZJF@1224|Proteobacteria,42M7S@68525|delta/epsilon subdivisions,2YNEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 CMS2_k127_4684058_3 1172190.M947_04185 8.418e-75 255.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42RES@68525|delta/epsilon subdivisions,2YP9Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 CMS2_k127_4684058_4 929558.SMGD1_1692 8.144e-46 167.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2YPSQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iIT341.HP1270 Oxidored_q2 CMS2_k127_4684058_0 1537917.JU82_10935 2.191e-306 948.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2YN0B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N CMS2_k127_4686181_29 929558.SMGD1_2645 1.452e-26 110.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2YMV9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW CMS2_k127_4686181_26 929558.SMGD1_2644 6.493e-39 151.0 COG2834@1|root,COG2834@2|Bacteria,1PQ15@1224|Proteobacteria,42WEH@68525|delta/epsilon subdivisions,2YPW1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA CMS2_k127_4686181_32 1385935.N836_22045 2.875e-17 94.0 COG2888@1|root,COG2888@2|Bacteria,1G0DV@1117|Cyanobacteria,1H8XN@1150|Oscillatoriales 1117|Cyanobacteria J peptidyl-tyrosine sulfation - - - - - - - - - - - - - CMS2_k127_4686181_10 261292.Nit79A3_1727 9.63e-154 494.0 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,372TF@32003|Nitrosomonadales 28216|Betaproteobacteria KT PFAM Metal-dependent phosphohydrolase, HD - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,GAF_2,HD CMS2_k127_4686181_14 572480.Arnit_1623 6.666e-119 393.0 COG2200@1|root,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,42S4U@68525|delta/epsilon subdivisions,2YTK1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T EAL domain protein - - - - - - - - - - - - EAL CMS2_k127_4686181_15 1442598.JABW01000012_gene378 2.037e-117 387.0 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,42V4B@68525|delta/epsilon subdivisions 1224|Proteobacteria S Sulphur transport soxT - - ko:K07112 - - - - ko00000 - - - Sulf_transp CMS2_k127_4686181_21 929558.SMGD1_1822 1.121e-70 256.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - 4HB_MCP_1,7TMR-DISMED2,7TMR-DISM_7TM,DUF3365,HATPase_c,HisKA,NMT1,PAS,PAS_3,PAS_9,PilJ,Response_reg,SBP_bac_3 CMS2_k127_4686181_30 1430440.MGMSRv2_0404 6.534e-23 113.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2JPFH@204441|Rhodospirillales 204441|Rhodospirillales NT methyl-accepting chemotaxis protein - - - - - - - - - - - - HAMP,Hemerythrin,MCPsignal CMS2_k127_4686181_12 563040.Saut_1011 3.936e-128 419.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,42KZV@68525|delta/epsilon subdivisions,2YM8J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase flgS - 2.7.13.3 ko:K02482,ko:K07710 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA CMS2_k127_4686181_20 929558.SMGD1_1605 4.904e-73 264.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - ABC_sub_bind,GAF_2,HAMP,HATPase_c,HisKA,MASE3,PAS,PAS_3,PAS_4,PAS_9,Response_reg CMS2_k127_4686181_8 1134474.O59_001318 7.071e-167 533.0 COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,1RPHR@1236|Gammaproteobacteria,1FGIB@10|Cellvibrio 1236|Gammaproteobacteria E Aminopeptidase I zinc metalloprotease (M18) apeB GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 CMS2_k127_4686181_31 5722.XP_001580301.1 1.646e-20 100.0 COG0666@1|root,KOG4177@2759|Eukaryota 2759|Eukaryota I spectrin binding - - - - - - - - - - - - Ank,Ank_2,Ank_3,Ank_4,Ank_5 CMS2_k127_4686181_0 563040.Saut_1008 0.0 1975.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2YMA1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP CMS2_k127_4686181_22 563040.Saut_0935 9.383e-70 240.0 COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,42RGX@68525|delta/epsilon subdivisions,2YPA8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TIGRFAM DJ-1 family protein thiJ - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI CMS2_k127_4686181_17 1249480.B649_07590 4.627e-100 328.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2YM7S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C CMS2_k127_4686181_25 929558.SMGD1_2541 2.795e-48 179.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,42QWJ@68525|delta/epsilon subdivisions,2YNVX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 CMS2_k127_4686181_18 1123326.JFBL01000021_gene2575 4.468e-96 338.0 COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,42PV8@68525|delta/epsilon subdivisions,2YMZX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,LapD_MoxY_N CMS2_k127_4686181_3 709032.Sulku_0886 5.039e-266 826.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2YMF3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT CMS2_k127_4686181_4 563040.Saut_0919 4.845e-259 807.0 COG0539@1|root,COG1107@1|root,COG0539@2|Bacteria,COG1107@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2YMBM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J ribosomal protein S1 rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 CMS2_k127_4686181_16 929558.SMGD1_2418 3.251e-102 344.0 COG2197@1|root,COG2197@2|Bacteria,1Q4EG@1224|Proteobacteria,42Z0G@68525|delta/epsilon subdivisions,2YRJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS2_k127_4686181_13 929558.SMGD1_0136 2.418e-123 400.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,42MJK@68525|delta/epsilon subdivisions,2YMV3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0400 LYTB CMS2_k127_4686181_6 563040.Saut_0917 5.502e-204 642.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2YMG2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase CMS2_k127_4686181_2 929558.SMGD1_0138 4.11e-282 886.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2YMAI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind CMS2_k127_4686181_7 929558.SMGD1_0139 1.223e-172 545.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2YMC0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d CMS2_k127_4686181_24 929558.SMGD1_0140 5.634e-54 191.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,42SEH@68525|delta/epsilon subdivisions,2YPE2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FG Hit family - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT CMS2_k127_4686181_23 929558.SMGD1_0146 3.968e-60 211.0 COG1765@1|root,COG1765@2|Bacteria,1NKRY@1224|Proteobacteria,42UP7@68525|delta/epsilon subdivisions,2YQ0P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O redox protein regulator of disulfide bond formation - - - ko:K07397 - - - - ko00000 - - - OsmC CMS2_k127_4686181_5 1537917.JU82_11200 6.374e-225 704.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2YMTB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 CMS2_k127_4686181_28 563040.Saut_0911 1.879e-31 126.0 28QM5@1|root,319KE@2|Bacteria,1Q3DZ@1224|Proteobacteria,42X5X@68525|delta/epsilon subdivisions,2YQT9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4686181_1 929558.SMGD1_0149 4.458e-296 917.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2YN0E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the UbiD family menA - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0396 UbiD CMS2_k127_4686181_11 326298.Suden_0863 1.206e-128 417.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2YN32@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC CMS2_k127_4686181_19 1249480.B649_07725 1.031e-84 289.0 COG1651@1|root,COG1651@2|Bacteria,1RFRJ@1224|Proteobacteria,42SPD@68525|delta/epsilon subdivisions,2YP88@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - - - - - - - - - - - Thioredoxin_4 CMS2_k127_4686181_9 709032.Sulku_0870 3.46e-158 506.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2YMKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit CMS2_k127_4727291_0 1249480.B649_06845 3.122e-80 273.0 2BV3K@1|root,32QGM@2|Bacteria,1Q4NH@1224|Proteobacteria,42ZI1@68525|delta/epsilon subdivisions,2YRN8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4727291_2 1249480.B649_06835 4.407e-35 139.0 COG1393@1|root,COG1393@2|Bacteria,1MZ7Z@1224|Proteobacteria,42VII@68525|delta/epsilon subdivisions,2YSA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the ArsC family - - - - - - - - - - - - ArsC CMS2_k127_4727291_1 1165841.SULAR_01968 1.487e-41 154.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,43AMB@68525|delta/epsilon subdivisions,2YT1W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg CMS2_k127_4860841_1 1537917.JU82_06385 4.076e-90 302.0 COG1579@1|root,COG1579@2|Bacteria,1R7GT@1224|Proteobacteria,42P3S@68525|delta/epsilon subdivisions,2YMAN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG1579 Zn-ribbon protein possibly nucleic acid-binding - - 3.5.4.16 ko:K07164,ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - zf-RING_7 CMS2_k127_4860841_0 929558.SMGD1_0774 1.106e-135 444.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2YN62@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M 3-deoxy-d-manno-octulosonic-acid transferase kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 iIT341.HP0957 Glycos_transf_N CMS2_k127_4911420_1 358681.BBR47_25580 3.836e-10 65.0 COG2963@1|root,COG2963@2|Bacteria,1VXIB@1239|Firmicutes,4HX5A@91061|Bacilli,27576@186822|Paenibacillaceae 91061|Bacilli L Putative ATPase subunit of terminase (gpP-like) - - - - - - - - - - - - HTH_28 CMS2_k127_4911420_0 1384065.JAGS01000001_gene2692 7.255e-76 265.0 COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,2487W@186801|Clostridia,3WIHV@541000|Ruminococcaceae 186801|Clostridia L Integrase core domain - - - - - - - - - - - - HTH_21,rve CMS2_k127_4921806_3 563040.Saut_1791 1.131e-206 657.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2YMVC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N CMS2_k127_4921806_8 1537917.JU82_03805 1.641e-57 202.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,42T1B@68525|delta/epsilon subdivisions,2YPHF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - PAS_3 CMS2_k127_4921806_6 709032.Sulku_0325 5.562e-77 282.0 COG2198@1|root,COG2198@2|Bacteria,1PCKH@1224|Proteobacteria,42W9Z@68525|delta/epsilon subdivisions,2YQ6K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - - CMS2_k127_4921806_1 1172190.M947_06560 0.0 1111.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2YMJS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,NIT,Response_reg CMS2_k127_4921806_9 1537917.JU82_03790 7.367e-50 179.0 COG2199@1|root,COG3706@2|Bacteria,1QUJM@1224|Proteobacteria,42TUI@68525|delta/epsilon subdivisions,2YPSC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Response regulator receiver - - - ko:K07814 - - - - ko00000,ko02022 - - - Response_reg CMS2_k127_4921806_0 709032.Sulku_0305 0.0 1245.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2YMNT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C CMS2_k127_4921806_5 563040.Saut_1797 3.113e-86 291.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,42RV8@68525|delta/epsilon subdivisions,2YPC0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO CMS2_k127_4921806_10 1249480.B649_01330 2.589e-38 149.0 COG1699@1|root,COG1699@2|Bacteria,1N347@1224|Proteobacteria,42RNU@68525|delta/epsilon subdivisions,2YQ0C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum - - - ko:K13626 - - - - ko00000,ko02035 - - - FliW CMS2_k127_4921806_4 563040.Saut_0816 3.641e-100 332.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2YNFY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer CMS2_k127_4921806_2 525898.Sdel_0857 1.919e-251 820.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - Hint_2 CMS2_k127_4921806_12 326298.Suden_0410 1.677e-15 85.0 COG2165@1|root,COG2165@2|Bacteria,1QUIZ@1224|Proteobacteria,43BJB@68525|delta/epsilon subdivisions,2YTBR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU general secretion pathway protein - - - - - - - - - - - - - CMS2_k127_4921806_7 563040.Saut_1800 1.734e-69 246.0 COG4968@1|root,COG4968@2|Bacteria,1QUIY@1224|Proteobacteria,42S53@68525|delta/epsilon subdivisions,2YPC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Prepilin-type N-terminal cleavage methylation domain - - - - - - - - - - - - N_methyl CMS2_k127_4921806_11 760154.Sulba_0911 2.584e-31 128.0 2AIWS@1|root,319ED@2|Bacteria,1Q2HE@1224|Proteobacteria,42VQ7@68525|delta/epsilon subdivisions,2YQ77@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_4994004_0 1165841.SULAR_07380 1.216e-110 369.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,42PUG@68525|delta/epsilon subdivisions,2YN09@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P TonB-dependent copper receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec CMS2_k127_5030_6 709032.Sulku_1732 1.657e-159 511.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2YMQ6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE CMS2_k127_5030_10 1172190.M947_10005 3.904e-91 308.0 28M05@1|root,32SJ0@2|Bacteria,1N115@1224|Proteobacteria,42ZGF@68525|delta/epsilon subdivisions,2YRPD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5030_15 335543.Sfum_0556 2.21e-66 248.0 COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1NQ5K@1224|Proteobacteria,42MAT@68525|delta/epsilon subdivisions,2WKY9@28221|Deltaproteobacteria,2MRZF@213462|Syntrophobacterales 28221|Deltaproteobacteria O PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - FGE-sulfatase,PEGA,Peptidase_C14 CMS2_k127_5030_17 1537917.JU82_04310 8.767e-57 202.0 COG0741@1|root,COG0741@2|Bacteria,1Q5W3@1224|Proteobacteria,431XB@68525|delta/epsilon subdivisions,2YSCH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M lytic transglycosylase activity - - - - - - - - - - - - SLT CMS2_k127_5030_23 1172190.M947_01850 7.2e-14 78.0 29DMK@1|root,300JF@2|Bacteria,1Q6BD@1224|Proteobacteria,432QV@68525|delta/epsilon subdivisions,2YSKF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5030_21 563040.Saut_1377 6.99e-37 142.0 2BR7U@1|root,32K64@2|Bacteria,1Q2P2@1224|Proteobacteria,431JX@68525|delta/epsilon subdivisions,2YSDV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5030_9 1249480.B649_04080 1.222e-101 333.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,42MQB@68525|delta/epsilon subdivisions,2YM8X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase CMS2_k127_5030_22 563040.Saut_1376 1.388e-15 79.0 COG3630@1|root,COG3630@2|Bacteria,1NFR4@1224|Proteobacteria,42XNE@68525|delta/epsilon subdivisions,2YQSS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxaloacetate decarboxylase, gamma chain oadG - 4.1.1.3 ko:K01573 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_gamma CMS2_k127_5030_1 1172190.M947_01830 0.0 1014.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1R5RS@1224|Proteobacteria,42M3K@68525|delta/epsilon subdivisions,2YN6E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM biotin lipoyl attachment domain-containing protein pycB - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA CMS2_k127_5030_3 326298.Suden_1258 4.604e-228 712.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2YNK3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C COG1883 Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit - - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta CMS2_k127_5030_7 1172190.M947_09625 7.45e-123 398.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2YN5P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA CMS2_k127_5030_2 326298.Suden_1326 3.52e-238 743.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,42N9T@68525|delta/epsilon subdivisions,2YMU2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF CMS2_k127_5030_0 1165841.SULAR_01270 0.0 2005.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2YMM4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh CMS2_k127_5030_16 1249480.B649_06650 3.383e-61 220.0 COG2199@1|root,COG2199@2|Bacteria,1Q4Z5@1224|Proteobacteria,4306K@68525|delta/epsilon subdivisions,2YRSF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T diguanylate cyclase activity - - - - - - - - - - - - GGDEF CMS2_k127_5030_5 709032.Sulku_1390 1.127e-183 581.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2YMIC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG CMS2_k127_5030_12 572480.Arnit_2897 2.751e-88 304.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,42P7C@68525|delta/epsilon subdivisions,2YP2R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M MltA specific insert domain mltA - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA CMS2_k127_5030_14 1537917.JU82_07875 1.008e-82 278.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,42QZJ@68525|delta/epsilon subdivisions,2YNXZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 CMS2_k127_5030_19 1219080.VEZ01S_24_00130 1.192e-50 199.0 COG2199@1|root,COG3322@1|root,COG3322@2|Bacteria,COG3706@2|Bacteria,1R895@1224|Proteobacteria,1S6XM@1236|Gammaproteobacteria,1XUVV@135623|Vibrionales 135623|Vibrionales KT Sensory box GGDEF family protein - - - - - - - - - - - - CHASE4,GGDEF CMS2_k127_5030_8 929558.SMGD1_2385 2.234e-115 378.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,42N54@68525|delta/epsilon subdivisions,2YNS5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N CMS2_k127_5030_24 318167.Sfri_2074 6.308e-12 70.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RWTI@1236|Gammaproteobacteria,2QDHU@267890|Shewanellaceae 1236|Gammaproteobacteria T Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - EAL,GGDEF,SBP_bac_3 CMS2_k127_5030_4 929558.SMGD1_2386 8.407e-221 692.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2YN93@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH anthranilate synthase component trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP1282 Anth_synt_I_N,Chorismate_bind CMS2_k127_5030_20 326298.Suden_1276 3.883e-48 181.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria 1224|Proteobacteria D Cell division protein ftsN - - ko:K03591,ko:K03749 - - - - ko00000,ko03036 - - - SPOR CMS2_k127_5030_11 1283300.ATXB01000001_gene428 5.517e-91 305.0 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria,1XFWX@135618|Methylococcales 135618|Methylococcales S VIT family - - - - - - - - - - - - VIT1 CMS2_k127_5030_13 472759.Nhal_3150 7.356e-84 283.0 COG0569@1|root,COG0569@2|Bacteria,1RDDX@1224|Proteobacteria,1S3ZR@1236|Gammaproteobacteria,1WY9A@135613|Chromatiales 135613|Chromatiales C TrkA-N domain - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N CMS2_k127_5030_18 472759.Nhal_3151 6.717e-53 192.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WXFD@135613|Chromatiales 135613|Chromatiales P PFAM Cation - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH CMS2_k127_5094005_0 929558.SMGD1_2831 6.64e-79 265.0 COG0301@1|root,COG0607@1|root,COG0301@2|Bacteria,COG0607@2|Bacteria,1MWD3@1224|Proteobacteria,42SKY@68525|delta/epsilon subdivisions,2YR1V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI - 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - - THUMP,ThiI CMS2_k127_5094005_1 1535422.ND16A_3271 7.447e-30 123.0 COG2832@1|root,COG2832@2|Bacteria,1PT7X@1224|Proteobacteria,1TAUF@1236|Gammaproteobacteria,2Q792@267889|Colwelliaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF454) - - - ko:K09790 - - - - ko00000 - - - DUF454 CMS2_k127_509737_0 1249480.B649_10700 9.82e-168 531.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2YMMS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 CMS2_k127_509737_1 929558.SMGD1_0895 1.108e-58 205.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,42SHZ@68525|delta/epsilon subdivisions,2YPDZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N CMS2_k127_509737_2 929558.SMGD1_0896 6.623e-12 65.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,42R1J@68525|delta/epsilon subdivisions,2YT60@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 CMS2_k127_5114181_4 563040.Saut_0368 6.79e-180 571.0 COG0475@1|root,COG0475@2|Bacteria,1QZMR@1224|Proteobacteria,43CKG@68525|delta/epsilon subdivisions,2YTDH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger CMS2_k127_5114181_0 1165841.SULAR_02003 0.0 1304.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0474 Cation transport ATPase - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,Na_H_Exchanger CMS2_k127_5114181_20 1165841.SULAR_06683 1.361e-50 181.0 2B9KW@1|root,322Z5@2|Bacteria,1RJJB@1224|Proteobacteria,42VPQ@68525|delta/epsilon subdivisions,2YRZA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5114181_10 1165841.SULAR_02033 3.139e-116 385.0 2A54K@1|root,30TT8@2|Bacteria,1Q98H@1224|Proteobacteria,4348V@68525|delta/epsilon subdivisions,2YRCN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5114181_16 1167006.UWK_03301 9.138e-80 272.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42PYJ@68525|delta/epsilon subdivisions,2WKHY@28221|Deltaproteobacteria,2MJ28@213118|Desulfobacterales 28221|Deltaproteobacteria V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_5114181_13 1167006.UWK_03302 2.826e-97 332.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42N3Y@68525|delta/epsilon subdivisions,2WJFS@28221|Deltaproteobacteria,2MJEA@213118|Desulfobacterales 28221|Deltaproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5114181_9 1167006.UWK_03303 9.789e-121 400.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42QGA@68525|delta/epsilon subdivisions,2WJYS@28221|Deltaproteobacteria,2MI4W@213118|Desulfobacterales 28221|Deltaproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD CMS2_k127_5114181_17 1165841.SULAR_02053 1.282e-76 264.0 COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria,42MIS@68525|delta/epsilon subdivisions,2YT08@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like CMS2_k127_5114181_21 387093.SUN_0378 8.882e-48 175.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2YPJX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS2_k127_5114181_19 697282.Mettu_2737 5.038e-53 193.0 296ZZ@1|root,2ZU8H@2|Bacteria,1RED2@1224|Proteobacteria,1S5WC@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5114181_2 1165841.SULAR_03567 8.348e-251 797.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions 1224|Proteobacteria O Belongs to the peptidase S16 family ycbZ - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C CMS2_k127_5114181_7 748247.AZKH_1502 5.009e-130 424.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 28216|Betaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG CMS2_k127_5114181_1 279714.FuraDRAFT_2622 1.005e-261 818.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KPV9@206351|Neisseriales 28216|Betaproteobacteria O Heat shock 70 kDa protein - - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 CMS2_k127_5114181_6 1172190.M947_02605 1.851e-156 507.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2YMQT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the peptidase S1C family htrA - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 CMS2_k127_5114181_18 706587.Desti_3417 7.244e-56 201.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WNF6@28221|Deltaproteobacteria,2MRJ8@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 CMS2_k127_5114181_5 929558.SMGD1_2071 1.755e-168 544.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S84@68525|delta/epsilon subdivisions,2YPD4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GGDEF domain - - - - - - - - - - - - GGDEF,PAS_8,dCache_3 CMS2_k127_5114181_12 929558.SMGD1_1919 7.678e-103 347.0 COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,42PHR@68525|delta/epsilon subdivisions,2YMDI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HD domain - - - - - - - - - - - - FIST,FIST_C,HD,PAS_3,PAS_9,Response_reg CMS2_k127_5114181_11 425104.Ssed_1154 5.977e-111 368.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1SAEA@1236|Gammaproteobacteria,2QCK3@267890|Shewanellaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF CMS2_k127_5114181_8 326298.Suden_1989 1.785e-125 405.0 COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2YNRA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme - - 2.1.1.107,4.2.1.75 ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - - TP_methylase CMS2_k127_5114181_14 563040.Saut_0826 1.819e-83 282.0 COG1648@1|root,COG1648@2|Bacteria,1RB3H@1224|Proteobacteria,42QT2@68525|delta/epsilon subdivisions,2YP97@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H COG1648 Siroheme synthase (precorrin-2 oxidase ferrochelatase domain) - - 1.3.1.76,4.99.1.4 ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_7,Sirohm_synth_M CMS2_k127_5114181_15 929558.SMGD1_1439 9.336e-82 285.0 COG0451@1|root,COG0451@2|Bacteria,1QY1S@1224|Proteobacteria,42X11@68525|delta/epsilon subdivisions,2YS6I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM ADP-glyceromanno-heptose 6-epimerase activity - - - - - - - - - - - - - CMS2_k127_5114181_3 929558.SMGD1_2357 1.253e-207 654.0 COG0591@1|root,COG0591@2|Bacteria,1MWX6@1224|Proteobacteria 1224|Proteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family mctP - - ko:K03307 - - - - ko00000 2.A.21 - - SSF CMS2_k127_5123329_1 1049564.TevJSym_cx00010 6.982e-57 201.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1JAD3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 CMS2_k127_5123329_0 1049564.TevJSym_cx00010 1.318e-162 521.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RR2W@1236|Gammaproteobacteria,1JAD3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 CMS2_k127_5140458_2 326298.Suden_0724 2.501e-133 429.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,42NB2@68525|delta/epsilon subdivisions,2YMVN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP CMS2_k127_5140458_13 929558.SMGD1_0390 1.286e-48 177.0 COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SJM@68525|delta/epsilon subdivisions,2YPJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 CMS2_k127_5140458_15 326298.Suden_0726 2.814e-35 137.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2YPU9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 CMS2_k127_5140458_10 929558.SMGD1_0387 1.411e-71 246.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,42RBS@68525|delta/epsilon subdivisions,2YTD0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT PAS fold - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - PAS_3 CMS2_k127_5140458_1 929558.SMGD1_0386 7.081e-268 837.0 COG0840@1|root,COG0840@2|Bacteria,1N5N4@1224|Proteobacteria,42RSG@68525|delta/epsilon subdivisions,2YRU6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal CMS2_k127_5140458_7 929558.SMGD1_0385 3.861e-98 336.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42TH2@68525|delta/epsilon subdivisions 1224|Proteobacteria NT Two component signalling adaptor domain cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW CMS2_k127_5140458_3 929558.SMGD1_0384 1.698e-124 407.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2YNWH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg CMS2_k127_5140458_9 929558.SMGD1_0383 2.029e-73 252.0 COG1413@1|root,COG1413@2|Bacteria,1RIZR@1224|Proteobacteria 1224|Proteobacteria C HEAT repeats - - - - - - - - - - - - HEAT_2 CMS2_k127_5140458_4 929558.SMGD1_0382 1.584e-115 377.0 COG1352@1|root,COG1352@2|Bacteria,1MVP3@1224|Proteobacteria,42SZX@68525|delta/epsilon subdivisions,2YTRV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Methyltransferase, chemotaxis proteins - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR CMS2_k127_5140458_12 929558.SMGD1_0381 2.424e-55 196.0 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,42SAC@68525|delta/epsilon subdivisions 1224|Proteobacteria T PFAM response regulator receiver cheY34H-1 - 2.7.13.3 ko:K03407,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - Response_reg CMS2_k127_5140458_14 929558.SMGD1_0379 1.052e-47 173.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain cheY40H-4 - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg CMS2_k127_5140458_6 1123372.AUIT01000012_gene1647 1.361e-110 391.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2GICN@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria NT Signal transducing histidine kinase, homodimeric domain - - - - - - - - - - - - CheW,H-kinase_dim,HATPase_c,Hpt CMS2_k127_5140458_18 573413.Spirs_1525 4.893e-17 91.0 COG0835@1|root,COG0835@2|Bacteria 2|Bacteria NT chemotaxis cheW3 - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW CMS2_k127_5140458_5 929558.SMGD1_0375 2.452e-113 370.0 COG1192@1|root,COG1192@2|Bacteria,1R7XC@1224|Proteobacteria 1224|Proteobacteria D NUBPL iron-transfer P-loop NTPase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 CMS2_k127_5140458_8 929558.SMGD1_0374 3.808e-94 325.0 COG3437@1|root,COG3437@2|Bacteria,1QYD6@1224|Proteobacteria,43CBH@68525|delta/epsilon subdivisions,2YTB6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T cheY-homologous receiver domain - - 3.1.1.61,3.5.1.44 ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - Response_reg CMS2_k127_5140458_11 1537917.JU82_04905 2.592e-67 234.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2YPMC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE CMS2_k127_5140458_0 1172190.M947_03510 5.4e-275 849.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2YMRM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 CMS2_k127_5143363_7 563040.Saut_0576 1.492e-44 164.0 COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2YN0V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Potassium channel protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N CMS2_k127_5143363_9 1537917.JU82_04040 1.144e-27 112.0 COG0227@1|root,COG0227@2|Bacteria,1PTFN@1224|Proteobacteria,42V1S@68525|delta/epsilon subdivisions,2YQAP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 CMS2_k127_5143363_3 326298.Suden_1603 1.951e-88 299.0 COG1639@1|root,COG1639@2|Bacteria,1Q1C5@1224|Proteobacteria,42T98@68525|delta/epsilon subdivisions,2YPNT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HDOD domain - - - - - - - - - - - - HDOD CMS2_k127_5143363_1 1249480.B649_01680 7.308e-184 585.0 COG1776@1|root,COG1776@2|Bacteria,1RICK@1224|Proteobacteria,42NMU@68525|delta/epsilon subdivisions,2YMV4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Chemotaxis phosphatase CheX - - - - - - - - - - - - CheX CMS2_k127_5143363_8 326298.Suden_0628 1.99e-44 164.0 COG0848@1|root,COG0848@2|Bacteria,1N9DN@1224|Proteobacteria,42V0H@68525|delta/epsilon subdivisions,2YQ7R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U biopolymer transport protein exbD - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD CMS2_k127_5143363_6 709032.Sulku_2074 7.021e-56 199.0 COG0811@1|root,COG0811@2|Bacteria,1RK2P@1224|Proteobacteria,42TPV@68525|delta/epsilon subdivisions,2YPGE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Biopolymer transporter ExbB - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB CMS2_k127_5143363_5 387092.NIS_1425 3.787e-56 206.0 COG0642@1|root,COG2205@2|Bacteria,1R5ZF@1224|Proteobacteria,43CBR@68525|delta/epsilon subdivisions,2YTBD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA CMS2_k127_5143363_4 387093.SUN_2187 5.069e-61 217.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,42SSI@68525|delta/epsilon subdivisions,2YPDF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_5143363_2 1172190.M947_11465 1.002e-174 553.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,42ND2@68525|delta/epsilon subdivisions,2YMQ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_2 CMS2_k127_5143363_0 563040.Saut_0647 9.439e-202 637.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2YMVE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G phosphomannomutase glmM_1 - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV CMS2_k127_5143363_10 563040.Saut_0672 2.677e-17 92.0 COG0810@1|root,COG0810@2|Bacteria,1R7A2@1224|Proteobacteria,42V42@68525|delta/epsilon subdivisions,2YQIP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C CMS2_k127_5146471_3 452471.Aasi_1627 0.0001239 53.0 COG0790@1|root,COG4886@1|root,COG0790@2|Bacteria,COG4886@2|Bacteria 2|Bacteria S regulation of response to stimulus - - - ko:K07126 - - - - ko00000 - - - LRR_8,Peptidase_C14,Sel1 CMS2_k127_5146471_0 563040.Saut_1056 5.202e-151 482.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2YMHR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus CMS2_k127_5146471_2 563040.Saut_0860 2.205e-99 329.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2YMD4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulatory protein yebC - - - - - - - - - - - Transcrip_reg CMS2_k127_5146471_1 1123326.JFBL01000002_gene1574 1.627e-106 358.0 COG2200@1|root,COG2200@2|Bacteria,1PDZY@1224|Proteobacteria,42R3Q@68525|delta/epsilon subdivisions,2YP1E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL CMS2_k127_5146522_6 1172190.M947_07125 1.5e-91 307.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42R9F@68525|delta/epsilon subdivisions,2YNVJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind CMS2_k127_5146522_3 749222.Nitsa_0232 2.237e-158 508.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2YMCS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 CMS2_k127_5146522_0 326298.Suden_0338 0.0 1090.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2YMEN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N CMS2_k127_5146522_5 929558.SMGD1_0922 4.094e-127 411.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2YMV8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10 ko:K00795 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364 R01658,R02003 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt CMS2_k127_5146522_9 929558.SMGD1_0924 7.337e-54 201.0 COG0265@1|root,COG0265@2|Bacteria,1QVTI@1224|Proteobacteria,42UMN@68525|delta/epsilon subdivisions,2YQ3C@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O PDZ domain - - - - - - - - - - - - PDZ_2 CMS2_k127_5146522_10 387093.SUN_2278 2.042e-32 128.0 COG0718@1|root,COG0718@2|Bacteria,1Q3T8@1224|Proteobacteria,42UGW@68525|delta/epsilon subdivisions,2YPUE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd CMS2_k127_5146522_7 563040.Saut_0299 2.929e-65 224.0 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,42SBM@68525|delta/epsilon subdivisions,2YPGH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox CMS2_k127_5146522_8 563040.Saut_0298 8.43e-57 201.0 COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,42SE0@68525|delta/epsilon subdivisions,2YPJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx CMS2_k127_5146522_1 1565314.OA34_01675 1.734e-207 662.0 COG2010@1|root,COG2010@2|Bacteria,1NG71@1224|Proteobacteria,42P5C@68525|delta/epsilon subdivisions,2YNRE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - - - - - - - - - - - CMS2_k127_5146522_2 1056820.KB900640_gene285 3.31e-191 616.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,1RSM7@1236|Gammaproteobacteria,2PQ7K@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 CMS2_k127_5146522_11 55601.VANGNB10_cI1231 4.616e-23 107.0 COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XSBS@135623|Vibrionales 135623|Vibrionales Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Calx-beta,HemolysinCabind,VWA_2 CMS2_k127_5146522_4 1537917.JU82_10950 4.61e-128 431.0 COG0457@1|root,COG0457@2|Bacteria,1QV1A@1224|Proteobacteria,42MIW@68525|delta/epsilon subdivisions,2YMDB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Paralysed flagella protein pflA - - - - - - - - - - - TPR_21,TPR_6,TPR_8,YfiO CMS2_k127_5148006_3 1537917.JU82_05050 1.351e-55 196.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,43B0D@68525|delta/epsilon subdivisions,2YT4V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RluA family - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 CMS2_k127_5148006_2 929558.SMGD1_1237 3.459e-273 842.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2YMZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 CMS2_k127_5148006_0 563040.Saut_2157 0.0 1427.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2YN94@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN CMS2_k127_5148006_4 563040.Saut_2158 9.024e-16 81.0 2BTTK@1|root,32P16@2|Bacteria,1Q41F@1224|Proteobacteria,42Y3I@68525|delta/epsilon subdivisions,2YQQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5148006_1 326298.Suden_0006 0.0 1056.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2YN4P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 CMS2_k127_5150602_14 1249480.B649_00110 5.736e-09 60.0 COG3203@1|root,COG3203@2|Bacteria,1QZ2N@1224|Proteobacteria,42QVI@68525|delta/epsilon subdivisions,2YP28@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - - CMS2_k127_5150602_15 709032.Sulku_0099 1.103e-07 57.0 2AJ3H@1|root,319MX@2|Bacteria,1Q39A@1224|Proteobacteria,42WZA@68525|delta/epsilon subdivisions,2YQQE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - DUF2892 CMS2_k127_5150602_1 709032.Sulku_1256 8.19e-223 695.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,42MHN@68525|delta/epsilon subdivisions,2YMYK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Involved in arsenical resistance. Thought to form the channel of an arsenite pump arsB - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - ArsB CMS2_k127_5150602_9 944547.ABLL_0313 7.348e-57 204.0 COG0394@1|root,COG0394@2|Bacteria,1REU2@1224|Proteobacteria,42SC5@68525|delta/epsilon subdivisions,2YPPW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Low molecular weight phosphotyrosine protein phosphatase arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc CMS2_k127_5150602_11 563040.Saut_0434 2.946e-47 171.0 COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42U0X@68525|delta/epsilon subdivisions,2YPSD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 CMS2_k127_5150602_12 1165841.SULAR_01120 2.16e-44 166.0 COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria 1224|Proteobacteria E glyoxalase bleomycin resistance protein dioxygenase cadI - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase CMS2_k127_5150602_8 929558.SMGD1_1208 1.479e-60 219.0 COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,42VE6@68525|delta/epsilon subdivisions,2YRDJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - - CMS2_k127_5150602_5 1172190.M947_07985 9.42e-95 316.0 COG1108@1|root,COG1108@2|Bacteria,1Q1MX@1224|Proteobacteria,42U0F@68525|delta/epsilon subdivisions,2YRI4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U ABC 3 transport family - - - ko:K02075 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ABC-3 CMS2_k127_5150602_3 1172190.M947_07980 1.348e-129 419.0 COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2YNF1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0803 ABC-type metal ion transport system, periplasmic component surface adhesin - - - ko:K02077 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ZnuA CMS2_k127_5150602_2 1172190.M947_07975 3.601e-158 509.0 COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,42NVN@68525|delta/epsilon subdivisions,2YMH8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P phosphate-selective porin O and P - - - - - - - - - - - - - CMS2_k127_5150602_4 387093.SUN_0787 4.405e-104 351.0 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,43CMA@68525|delta/epsilon subdivisions,2YRH0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c CMS2_k127_5150602_6 563040.Saut_2059 1.218e-77 265.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,42SZP@68525|delta/epsilon subdivisions,2YSYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_5150602_7 1265505.ATUG01000002_gene2485 1.106e-71 251.0 2BT8X@1|root,32NEA@2|Bacteria,1RGSX@1224|Proteobacteria,42S0P@68525|delta/epsilon subdivisions,2WN9V@28221|Deltaproteobacteria,2MK2R@213118|Desulfobacterales 28221|Deltaproteobacteria S Predicted periplasmic lipoprotein (DUF2279) - - - - - - - - - - - - DUF2279 CMS2_k127_5150602_0 563040.Saut_2057 0.0 1644.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2YNKW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran CMS2_k127_5150602_10 563040.Saut_2045 7.484e-49 177.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2YPEZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M cation efflux system protein crdC - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - HlyD_D23,HlyD_D4 CMS2_k127_5159388_7 1249480.B649_03885 1.556e-124 406.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2YMBD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 CMS2_k127_5159388_12 929558.SMGD1_0303 7.294e-97 331.0 COG4733@1|root,COG4733@2|Bacteria,1N010@1224|Proteobacteria,42M7U@68525|delta/epsilon subdivisions,2YM7Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Fibronectin type 3 domain-containing protein - - - ko:K06882 - - - - ko00000 - - - fn3 CMS2_k127_5159388_4 563040.Saut_0810 1.733e-132 432.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,42M78@68525|delta/epsilon subdivisions,2YMR1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 CMS2_k127_5159388_10 929558.SMGD1_0301 2.035e-107 351.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2YT9B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D ABC transporter ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran CMS2_k127_5159388_20 537971.HCCG_00313 2.879e-35 145.0 COG2177@1|root,COG2177@2|Bacteria,1R85B@1224|Proteobacteria,42PX3@68525|delta/epsilon subdivisions,2YNQW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Cell division protein FtsX ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - CMS2_k127_5159388_14 1172190.M947_09645 3.783e-93 320.0 COG4942@1|root,COG4942@2|Bacteria,1QV6K@1224|Proteobacteria,42M9V@68525|delta/epsilon subdivisions,2YMS7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 CMS2_k127_5159388_3 709032.Sulku_0737 1.085e-132 436.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,42QG6@68525|delta/epsilon subdivisions,2YMUP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V na -driven multidrug efflux - - - - - - - - - - - - MatE CMS2_k127_5159388_23 1249480.B649_08665 5.572e-26 109.0 2BJZK@1|root,32ECD@2|Bacteria,1QDIV@1224|Proteobacteria,433KD@68525|delta/epsilon subdivisions,2YSRX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5159388_17 387093.SUN_0978 3.014e-59 211.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42TAC@68525|delta/epsilon subdivisions,2YRI5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG2518 Protein-L-isoaspartate carboxylmethyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT CMS2_k127_5159388_15 472759.Nhal_3098 4.708e-90 310.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Amino Acid - - - - - - - - - - - - AA_permease_2 CMS2_k127_5159388_5 326298.Suden_1371 1.625e-129 425.0 COG0477@1|root,COG2814@2|Bacteria,1QRUM@1224|Proteobacteria,42MFJ@68525|delta/epsilon subdivisions,2YMW9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EGP Major Facilitator - - - - - - - - - - - - MFS_1 CMS2_k127_5159388_22 709032.Sulku_0734 3.51e-27 114.0 COG1334@1|root,COG1334@2|Bacteria,1NH9T@1224|Proteobacteria,42X2H@68525|delta/epsilon subdivisions,2YR05@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N FlaG protein - - - ko:K06603 - - - - ko00000,ko02035 - - - FlaG CMS2_k127_5159388_16 1249480.B649_00720 9.978e-81 286.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,42MHW@68525|delta/epsilon subdivisions,2YNJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N CMS2_k127_5159388_19 709032.Sulku_0733 2.494e-48 175.0 COG1516@1|root,COG1516@2|Bacteria,1PSYY@1224|Proteobacteria,42V8K@68525|delta/epsilon subdivisions,2YQ35@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar protein FliS fliS - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS CMS2_k127_5159388_0 1172190.M947_02180 7.845e-240 744.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2YMAU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth CMS2_k127_5159388_9 1537917.JU82_04510 1.45e-109 358.0 COG0607@1|root,COG4802@1|root,COG0607@2|Bacteria,COG4802@2|Bacteria,1QYD3@1224|Proteobacteria,42PN1@68525|delta/epsilon subdivisions,2YMYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP PFAM Ferredoxin thioredoxin reductase catalytic beta chain - - - - - - - - - - - - FeThRed_B,Rhodanese CMS2_k127_5159388_18 1123326.JFBL01000006_gene959 8.597e-50 181.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2YPEP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N CMS2_k127_5159388_13 326298.Suden_1376 4.444e-95 313.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2YMFC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome CMS2_k127_5159388_1 1172190.M947_02205 4.85e-202 637.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2YMM2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small CMS2_k127_5159388_6 709032.Sulku_0726 4.568e-125 406.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,42MUR@68525|delta/epsilon subdivisions,2YMG3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 CMS2_k127_5159388_11 563040.Saut_0872 4.002e-98 330.0 COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,42QS4@68525|delta/epsilon subdivisions,2YNYQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S ErfK YbiS YcfS YnhG family protein pgp2 - - - - - - - - - - - YkuD CMS2_k127_5159388_8 1537917.JU82_08730 1.967e-122 406.0 COG3608@1|root,COG3608@2|Bacteria,1Q5G3@1224|Proteobacteria,42MSH@68525|delta/epsilon subdivisions,2YMTA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S C-terminal domain of metallo-carboxypeptidase - - - - - - - - - - - - Peptidase_M99,Peptidase_M99_C CMS2_k127_5159388_2 709032.Sulku_0723 2.623e-165 534.0 COG4972@1|root,COG4972@2|Bacteria,1QA6M@1224|Proteobacteria,42NDB@68525|delta/epsilon subdivisions,2YMP2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Pilus assembly protein - - - - - - - - - - - - - CMS2_k127_5159388_21 709032.Sulku_0722 9.153e-28 118.0 2AIDI@1|root,31TAR@2|Bacteria,1QR0P@1224|Proteobacteria,42TWA@68525|delta/epsilon subdivisions,2YSYQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - PilO CMS2_k127_5164539_1 1537917.JU82_07070 5.775e-121 391.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,42NRX@68525|delta/epsilon subdivisions,2YMSK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth CMS2_k127_5164539_5 1537917.JU82_07065 1.617e-102 336.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,42QX8@68525|delta/epsilon subdivisions,2YP1G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase CMS2_k127_5164539_4 1249480.B649_09090 1.897e-108 360.0 28M05@1|root,2ZAF9@2|Bacteria,1MY5U@1224|Proteobacteria,42MJP@68525|delta/epsilon subdivisions,2YMVI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S General glycosylation pathway protein pglG - - - - - - - - - - - dCache_1 CMS2_k127_5164539_6 929558.SMGD1_1833 5.91e-100 336.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,42NRP@68525|delta/epsilon subdivisions,2YN5U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M lipopolysaccharide heptosyltransferase waaC - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 CMS2_k127_5164539_7 1172190.M947_03300 3.974e-73 256.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2YMCX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M lipid a biosynthesis waaM - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans CMS2_k127_5164539_8 367737.Abu_0795 6.658e-59 206.0 COG1051@1|root,COG1051@2|Bacteria,1QUM0@1224|Proteobacteria,42SY6@68525|delta/epsilon subdivisions,2YPEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F ADP-ribose pyrophosphatase - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX CMS2_k127_5164539_2 929558.SMGD1_1804 1.257e-116 387.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,42N4K@68525|delta/epsilon subdivisions,2YMVY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S HI0933 family - - - ko:K07007 - - - - ko00000 - - - HI0933_like CMS2_k127_5164539_10 653733.Selin_0844 3.113e-24 111.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding iprA GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K21828 - - - - ko00000,ko03000 - - - HTH_46,HTH_Crp_2,cNMP_binding CMS2_k127_5164539_9 709032.Sulku_0309 5.498e-42 162.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,42VZ2@68525|delta/epsilon subdivisions,2YQGP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C PFAM Ferric reductase domain protein transmembrane component domain - - - ko:K17247 - - - - ko00000 - - - Ferric_reduct CMS2_k127_5164539_0 1123326.JFBL01000002_gene1571 3.672e-123 403.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,42P5V@68525|delta/epsilon subdivisions,2YNBJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb CMS2_k127_5164539_3 929558.SMGD1_2814 3.127e-110 366.0 COG1409@1|root,COG1409@2|Bacteria,1N85S@1224|Proteobacteria,42WZ6@68525|delta/epsilon subdivisions 1224|Proteobacteria G Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,Metallophos_C,PKD,Pur_ac_phosph_N CMS2_k127_5168511_0 563040.Saut_0221 2.627e-107 350.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2YN05@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C CMS2_k127_5168511_2 563040.Saut_0222 9.949e-75 252.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2YNWG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 CMS2_k127_5168511_4 326298.Suden_0295 4.049e-38 143.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,42TNS@68525|delta/epsilon subdivisions,2YPV2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 CMS2_k127_5168511_3 563040.Saut_0225 2.874e-65 224.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,42RHR@68525|delta/epsilon subdivisions,2YP6F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 CMS2_k127_5168511_5 1537917.JU82_09525 5.919e-32 126.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,42TGC@68525|delta/epsilon subdivisions,2YQA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 CMS2_k127_5168511_1 1172190.M947_07385 2.423e-87 291.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2YN2M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C CMS2_k127_5168511_6 1172190.M947_07380 1.042e-31 125.0 COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2YQIN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 CMS2_k127_5171112_2 1165841.SULAR_01878 3.556e-17 81.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2YMH1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_5171112_0 1165841.SULAR_01873 1.402e-42 162.0 COG1853@1|root,COG1853@2|Bacteria,1RAIQ@1224|Proteobacteria,42QXX@68525|delta/epsilon subdivisions 1224|Proteobacteria S Flavin reductase like domain flr - - - - - - - - - - - Flavin_Reduct CMS2_k127_5171112_1 1165841.SULAR_01883 1.227e-31 130.0 COG4276@1|root,COG4276@2|Bacteria,1N2Z3@1224|Proteobacteria,42THP@68525|delta/epsilon subdivisions 1224|Proteobacteria S Pfam Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc CMS2_k127_5171112_3 944547.ABLL_0739 1.715e-07 53.0 COG3040@1|root,COG3040@2|Bacteria,1RIHP@1224|Proteobacteria,42SSW@68525|delta/epsilon subdivisions,2YPA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Lipocalin / cytosolic fatty-acid binding protein family - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 CMS2_k127_5200293_2 749222.Nitsa_0048 5.13e-15 81.0 2A4Y3@1|root,30TJW@2|Bacteria,1PDG3@1224|Proteobacteria,42X3Z@68525|delta/epsilon subdivisions,2YQTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5200293_3 312309.VF_2475 1.329e-08 66.0 COG3031@1|root,COG3031@2|Bacteria,1RD3I@1224|Proteobacteria,1RQKA@1236|Gammaproteobacteria,1XU1I@135623|Vibrionales 135623|Vibrionales U general secretion pathway protein epsC GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02452 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSC CMS2_k127_5200293_1 1123326.JFBL01000017_gene2328 1.364e-154 507.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2YNRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU general secretion pathway protein D - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N CMS2_k127_5200293_0 1165841.SULAR_08647 1.009e-183 587.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE CMS2_k127_5200293_4 2423.NA23_0209350 5.303e-05 47.0 COG1459@1|root,COG1459@2|Bacteria,2GCPR@200918|Thermotogae 200918|Thermotogae NU type II secretion system protein - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF CMS2_k127_5201073_1 387093.SUN_0794 1.535e-79 273.0 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,43A73@68525|delta/epsilon subdivisions,2YQWT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese CMS2_k127_5201073_0 929558.SMGD1_1626 1.187e-81 274.0 COG0500@1|root,COG0500@2|Bacteria,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42N5I@68525|delta/epsilon subdivisions 1224|Proteobacteria Q Methyltransferase type 11 - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_11,Methyltransf_31 CMS2_k127_5201442_0 592015.HMPREF1705_00643 3.514e-96 328.0 COG3464@1|root,COG3464@2|Bacteria,3TCGB@508458|Synergistetes 2|Bacteria L Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 CMS2_k127_5207859_7 929558.SMGD1_1237 4.121e-150 476.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2YMZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 CMS2_k127_5207859_9 1537917.JU82_05050 1.637e-118 389.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,43B0D@68525|delta/epsilon subdivisions,2YT4V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the pseudouridine synthase RluA family - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 CMS2_k127_5207859_2 1537917.JU82_05045 6.514e-232 731.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,42P71@68525|delta/epsilon subdivisions,2YNAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Phospholipid glycerol acyltransferase - - - - - - - - - - - - Acetyltransf_5,Acyltransferase CMS2_k127_5207859_16 709032.Sulku_1169 2.592e-39 150.0 COG0735@1|root,COG0735@2|Bacteria,1N0HW@1224|Proteobacteria,43B75@68525|delta/epsilon subdivisions,2YPV3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the Fur family - - - ko:K09825 - - - - ko00000,ko03000 - - - FUR CMS2_k127_5207859_10 387093.SUN_1880 1.877e-101 334.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2YT86@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Desulfoferrodoxin, N-terminal domain - - - - - - - - - - - - Desulfoferrod_N,Rubrerythrin CMS2_k127_5207859_6 326298.Suden_0214 3.46e-151 484.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N1I@68525|delta/epsilon subdivisions,2YMA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome ccpA - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C CMS2_k127_5207859_5 326298.Suden_0316 1.639e-162 523.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2YPJ6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T His Kinase A (phospho-acceptor) domain - - - - - - - - - - - - HATPase_c,HisKA CMS2_k127_5207859_13 1123326.JFBL01000007_gene578 8.889e-78 267.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2YNWQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C CMS2_k127_5207859_3 563040.Saut_1275 9.09e-220 693.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,42MI1@68525|delta/epsilon subdivisions,2YMPQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Sulfatase eptA - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase CMS2_k127_5207859_1 326298.Suden_0320 3.496e-292 910.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,42P62@68525|delta/epsilon subdivisions 1224|Proteobacteria M Sulfatase - - - - - - - - - - - - Sulfatase CMS2_k127_5207859_15 1304888.ATWF01000002_gene58 2.385e-55 205.0 COG2199@1|root,COG3706@2|Bacteria,2GFHC@200930|Deferribacteres 200930|Deferribacteres T SMART GGDEF domain containing protein - - - - - - - - - - - - GGDEF,Response_reg CMS2_k127_5207859_4 563040.Saut_2152 5.821e-180 568.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2YN3J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM CMS2_k127_5207859_11 563040.Saut_2151 6.089e-94 310.0 COG0775@1|root,COG0775@2|Bacteria,1R9VR@1224|Proteobacteria,42RM2@68525|delta/epsilon subdivisions,2YP67@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F phosphorylase - - - - - - - - - - - - PNP_UDP_1 CMS2_k127_5207859_8 1249480.B649_00505 1.061e-144 460.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2YMH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth,NMO CMS2_k127_5207859_17 639282.DEFDS_0652 1.959e-30 137.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - CBM_6,He_PIG,LVIVD,WD40 CMS2_k127_5207859_18 1165841.SULAR_06403 4.479e-24 104.0 COG0225@1|root,COG0225@2|Bacteria 2|Bacteria O peptide-methionine (S)-S-oxide reductase activity - - - - - - - - - - - - Thioredoxin_7 CMS2_k127_5207859_19 929558.SMGD1_2121 1.097e-13 76.0 29DMH@1|root,300JC@2|Bacteria,1Q6BB@1224|Proteobacteria,432SJ@68525|delta/epsilon subdivisions,2YSSN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5207859_14 326298.Suden_1962 2.949e-64 237.0 COG2199@1|root,COG3706@2|Bacteria,1QVPY@1224|Proteobacteria,43AMF@68525|delta/epsilon subdivisions,2YT22@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Chemoreceptor zinc-binding domain - - - - - - - - - - - - CZB,GGDEF CMS2_k127_5207859_0 1165841.SULAR_03527 3.5e-323 1001.0 COG0209@1|root,COG0693@1|root,COG0209@2|Bacteria,COG0693@2|Bacteria,1N0E3@1224|Proteobacteria,42QEY@68525|delta/epsilon subdivisions,2YNM2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Ribonucleotide reductase, barrel domain - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC CMS2_k127_5207859_12 1249480.B649_00500 2.996e-83 280.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2YNGY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD CMS2_k127_5230859_6 1165841.SULAR_01878 8.756e-96 315.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2YMH1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP CMS2_k127_5230859_11 1165841.SULAR_01873 5.455e-43 163.0 COG1853@1|root,COG1853@2|Bacteria,1RAIQ@1224|Proteobacteria,42QXX@68525|delta/epsilon subdivisions 1224|Proteobacteria S Flavin reductase like domain flr - - - - - - - - - - - Flavin_Reduct CMS2_k127_5230859_15 1165841.SULAR_01883 1.232e-28 121.0 COG4276@1|root,COG4276@2|Bacteria,1N2Z3@1224|Proteobacteria,42THP@68525|delta/epsilon subdivisions 1224|Proteobacteria S Pfam Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc CMS2_k127_5230859_9 944547.ABLL_0739 7.313e-66 229.0 COG3040@1|root,COG3040@2|Bacteria,1RIHP@1224|Proteobacteria,42SSW@68525|delta/epsilon subdivisions,2YPA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Lipocalin / cytosolic fatty-acid binding protein family - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 CMS2_k127_5230859_17 520709.F985_02117 1.656e-18 90.0 COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1SAFA@1236|Gammaproteobacteria,3NMFC@468|Moraxellaceae 1236|Gammaproteobacteria S Sensors of blue-light using FAD - - - - - - - - - - - - BLUF CMS2_k127_5230859_1 1165841.SULAR_01828 1.162e-199 631.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,42MQ6@68525|delta/epsilon subdivisions,2YNPN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the DNA photolyase family phrB - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 CMS2_k127_5230859_3 1165841.SULAR_01818 2.685e-132 428.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2YMY0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 CMS2_k127_5230859_16 572480.Arnit_0389 1.413e-26 113.0 COG2138@1|root,COG2138@2|Bacteria,1PRX7@1224|Proteobacteria,42VX1@68525|delta/epsilon subdivisions,2YSGT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Cobalt chelatase (CbiK) - - 4.99.1.3 ko:K03795 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05807 RC01012 ko00000,ko00001,ko01000 - - - CbiX CMS2_k127_5230859_4 1165841.SULAR_01813 6.807e-129 417.0 COG0715@1|root,COG0715@2|Bacteria,1MVRA@1224|Proteobacteria,42M17@68525|delta/epsilon subdivisions 1224|Proteobacteria P NMT1/THI5 like thi - - ko:K15598 ko02010,map02010 M00442 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.3,3.A.1.17.6 - - NMT1 CMS2_k127_5230859_8 1165841.SULAR_01808 5.417e-85 286.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42TAK@68525|delta/epsilon subdivisions,2YPP9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI CMS2_k127_5230859_7 1165841.SULAR_01803 3.498e-91 306.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,42N1F@68525|delta/epsilon subdivisions,2YP5A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin CMS2_k127_5230859_10 1121935.AQXX01000116_gene5183 1.102e-50 181.0 COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,1S688@1236|Gammaproteobacteria,1XPP3@135619|Oceanospirillales 135619|Oceanospirillales S Evidence 4 Homologs of previously reported genes of - - - ko:K09700 - - - - ko00000 - - - - CMS2_k127_5230859_0 1123514.KB905899_gene1989 4.961e-208 654.0 COG0531@1|root,COG0531@2|Bacteria,1PKIV@1224|Proteobacteria,1T9HU@1236|Gammaproteobacteria,461MJ@72273|Thiotrichales 72273|Thiotrichales E Amino acid permease - - - - - - - - - - - - AA_permease_2 CMS2_k127_5230859_2 572480.Arnit_2887 3.602e-178 565.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2YNUK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp CMS2_k127_5230859_12 748658.KB907312_gene1460 3.688e-40 151.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1WY86@135613|Chromatiales 135613|Chromatiales K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II CMS2_k127_5230859_5 1537917.JU82_11020 2.25e-98 335.0 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane oprD - - ko:K08720,ko:K18093 ko01501,ko02020,ko05111,map01501,map02020,map05111 M00745 - - ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 1.B.1.2.1,1.B.25.1.1 - iJN746.PP_1206 Alginate_exp,BBP2,OprD,Porin_4 CMS2_k127_5230859_13 273121.WS1110 2.796e-30 121.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,42NMD@68525|delta/epsilon subdivisions,2YR0T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 CMS2_k127_5236715_2 929558.SMGD1_2831 9.899e-45 164.0 COG0301@1|root,COG0607@1|root,COG0301@2|Bacteria,COG0607@2|Bacteria,1MWD3@1224|Proteobacteria,42SKY@68525|delta/epsilon subdivisions,2YR1V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI - 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - - THUMP,ThiI CMS2_k127_5236715_0 697282.Mettu_2681 6.265e-208 683.0 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,1XDR7@135618|Methylococcales 135618|Methylococcales KL DNA RNA helicase - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM CMS2_k127_5236715_1 29495.EA26_19835 9.304e-48 177.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1XT1I@135623|Vibrionales 135623|Vibrionales S hydrolase of the alpha beta-hydrolase fold yheT - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 CMS2_k127_5263257_1 572480.Arnit_2764 0.0007365 43.0 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - - ko:K07126 - - - - ko00000 - - - Sel1,TPR_10,TPR_8 CMS2_k127_5263257_0 572480.Arnit_1760 8.491e-146 479.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,42Q4M@68525|delta/epsilon subdivisions,2YN67@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD,Prok-TraM CMS2_k127_5277631_0 207954.MED92_11684 5.922e-70 242.0 29363@1|root,2ZQP5@2|Bacteria,1REQY@1224|Proteobacteria,1S7UU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5277631_3 387092.NIS_1293 1.797e-31 128.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,42S1N@68525|delta/epsilon subdivisions,2YPJI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin CMS2_k127_5277631_2 1165841.SULAR_02098 3.5e-35 143.0 arCOG08935@1|root,32Z08@2|Bacteria,1NC5T@1224|Proteobacteria,42XQ1@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_5277631_1 387092.NIS_1293 8.597e-37 143.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,42S1N@68525|delta/epsilon subdivisions,2YPJI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin CMS2_k127_5277631_5 1249480.B649_10790 9.096e-18 85.0 COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,42SE0@68525|delta/epsilon subdivisions,2YPJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx CMS2_k127_5288246_2 563040.Saut_1598 8.441e-45 164.0 COG3439@1|root,COG3439@2|Bacteria 2|Bacteria D Domain of unknown function DUF302 - - - - - - - - - - - - - CMS2_k127_5288246_1 1121403.AUCV01000003_gene1692 7.472e-170 536.0 COG2191@1|root,COG2191@2|Bacteria,1NX7R@1224|Proteobacteria,430UJ@68525|delta/epsilon subdivisions,2WVSG@28221|Deltaproteobacteria,2MNK7@213118|Desulfobacterales 28221|Deltaproteobacteria C FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - - - - - - - - - - - FmdE CMS2_k127_5288246_0 326298.Suden_1815 6.699e-170 542.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2YNBN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M CMS2_k127_5305355_0 1537917.JU82_00830 8.436e-150 478.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2YMPB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Glycerol-3-phosphate dehydrogenase glpC - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 CMS2_k127_5305355_1 387092.NIS_0370 2.34e-119 389.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2YMER@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT CMS2_k127_5305355_2 563040.Saut_1739 1.424e-15 77.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2YNID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S acid membrane antigen A amaA - - - - - - - - - - - AI-2E_transport CMS2_k127_530812_34 944547.ABLL_0600 8.742e-61 216.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CHE@68525|delta/epsilon subdivisions,2YRKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HAMP domain - - - - - - - - - - - - HATPase_c CMS2_k127_530812_31 929558.SMGD1_0374 4.106e-72 259.0 COG3437@1|root,COG3437@2|Bacteria,1QYD6@1224|Proteobacteria,43CBH@68525|delta/epsilon subdivisions,2YTB6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T cheY-homologous receiver domain - - 3.1.1.61,3.5.1.44 ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - Response_reg CMS2_k127_530812_27 1304888.ATWF01000001_gene2325 8.366e-90 331.0 COG2199@1|root,COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,2GGBB@200930|Deferribacteres 200930|Deferribacteres T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,PAS_9 CMS2_k127_530812_33 944546.ABED_0430 9.524e-62 243.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CHE@68525|delta/epsilon subdivisions,2YRKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HAMP domain - - - - - - - - - - - - HATPase_c CMS2_k127_530812_17 563040.Saut_1004 1.584e-125 413.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2YNG4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 CMS2_k127_530812_51 709032.Sulku_1028 1.502e-21 99.0 COG2863@1|root,COG2863@2|Bacteria,1PFA2@1224|Proteobacteria,42XJ8@68525|delta/epsilon subdivisions,2YQVM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C cytochrome c class I - - - - - - - - - - - - Cytochrom_C CMS2_k127_530812_45 1537917.JU82_10565 1.024e-33 134.0 COG0526@1|root,COG0526@2|Bacteria,1R1JZ@1224|Proteobacteria,43EIF@68525|delta/epsilon subdivisions,2YTHD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredoxin_7 CMS2_k127_530812_8 1537917.JU82_10560 3.325e-163 533.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2YMEZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thiol disulfide interchange protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_2,Thioredoxin_7 CMS2_k127_530812_32 32024.JMTI01000049_gene1373 5.328e-63 244.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions,2YMNU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,PAS,PAS_3,PAS_9 CMS2_k127_530812_36 929558.SMGD1_2419 5.175e-54 205.0 COG2197@1|root,COG4191@1|root,COG2197@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M6C@68525|delta/epsilon subdivisions,2YRVE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T GHKL domain - - - - - - - - - - - - HATPase_c,Response_reg CMS2_k127_530812_14 563040.Saut_0970 2.472e-133 431.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42M26@68525|delta/epsilon subdivisions,2YMEG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S polyphosphate kinase ppk2 - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 CMS2_k127_530812_3 563040.Saut_0814 2.135e-242 756.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42MXQ@68525|delta/epsilon subdivisions,2YM9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0098 PALP,Thr_synth_N CMS2_k127_530812_23 1442598.JABW01000024_gene1567 4.29e-99 347.0 2DR8G@1|root,32UQM@2|Bacteria,1R7WP@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - CMS2_k127_530812_47 1122221.JHVI01000011_gene948 1.809e-27 114.0 COG1324@1|root,COG1324@2|Bacteria,1WKG6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P PFAM CutA1 divalent ion tolerance protein cutA - - ko:K03926 - - - - ko00000 - - - CutA1 CMS2_k127_530812_10 929558.SMGD1_0158 1.518e-144 462.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2YMHA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase CMS2_k127_530812_22 563040.Saut_0897 8.138e-101 337.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2YN18@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK CMS2_k127_530812_9 1537917.JU82_04480 6.307e-157 503.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2YMJQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.92 ko:K15895 ko00520,map00520 - R09825 RC00006,RC00781 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 CMS2_k127_530812_18 1537917.JU82_04475 4.502e-122 396.0 COG0171@1|root,COG0171@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2YNG2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase CMS2_k127_530812_25 1249480.B649_04210 1.768e-93 314.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,42KZ6@68525|delta/epsilon subdivisions,2YMPZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S hmm pf04305 - - - - - - - - - - - - DUF455 CMS2_k127_530812_24 563040.Saut_0893 4.445e-98 323.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2YNVD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases ycbL - - - - - - - - - - - Lactamase_B CMS2_k127_530812_41 1249480.B649_04200 8.399e-44 164.0 COG2050@1|root,COG2050@2|Bacteria,1N1PP@1224|Proteobacteria,42TRH@68525|delta/epsilon subdivisions,2YPTG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q thioesterase - - - ko:K02614 ko00360,map00360 - R09840 RC00004,RC00014 ko00000,ko00001,ko01000 - - - 4HBT CMS2_k127_530812_12 563040.Saut_0890 2.956e-137 441.0 COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,42N9H@68525|delta/epsilon subdivisions,2YMGK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs cmoB - - ko:K15257 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_9 CMS2_k127_530812_21 1158318.ATXC01000001_gene82 9.334e-103 342.0 COG0053@1|root,COG0053@2|Bacteria,2G3YC@200783|Aquificae 2|Bacteria P cation diffusion facilitator family transporter fieF GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874 - ko:K13283 - - - - ko00000,ko02000 2.A.4.7.1 - - Cation_efflux,ZT_dimer CMS2_k127_530812_43 563040.Saut_1435 7.504e-39 151.0 COG1472@1|root,COG1472@2|Bacteria,1QUPT@1224|Proteobacteria,42VS9@68525|delta/epsilon subdivisions,2YQD2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Cytochrome c family protein - - - - - - - - - - - - DUF3365 CMS2_k127_530812_5 563040.Saut_1436 2.299e-215 679.0 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2YMQS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 CMS2_k127_530812_39 1172190.M947_09410 3.237e-47 179.0 COG0212@1|root,COG0212@2|Bacteria,1RDZJ@1224|Proteobacteria,42SXM@68525|delta/epsilon subdivisions,2YPJD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig CMS2_k127_530812_38 326298.Suden_0844 8.274e-50 183.0 COG0526@1|root,COG0526@2|Bacteria,1RKKW@1224|Proteobacteria,42SHJ@68525|delta/epsilon subdivisions,2YPQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CO Thioredoxin-like resA - - - - - - - - - - - AhpC-TSA,Redoxin,Thioredoxin,Thioredoxin_8 CMS2_k127_530812_16 563040.Saut_1439 9.612e-129 418.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2YMT4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N CMS2_k127_530812_4 1537917.JU82_04415 3.89e-239 744.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2YMAP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI CMS2_k127_530812_50 1537917.JU82_04410 5.181e-22 98.0 2BS84@1|root,32M9E@2|Bacteria,1Q365@1224|Proteobacteria,42WU4@68525|delta/epsilon subdivisions,2YQWK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_530812_20 709032.Sulku_1596 2.041e-109 360.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2YMCB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q ABC-type transport system involved in resistance to organic solvents permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE CMS2_k127_530812_37 1537917.JU82_04395 4.809e-50 184.0 COG1580@1|root,COG1580@2|Bacteria,1NBUX@1224|Proteobacteria,42RSV@68525|delta/epsilon subdivisions,2YPAW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL CMS2_k127_530812_42 1249480.B649_04135 2.953e-43 160.0 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,42TWY@68525|delta/epsilon subdivisions,2YPX1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS CMS2_k127_530812_49 563040.Saut_1445 2.973e-22 97.0 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,42WUA@68525|delta/epsilon subdivisions,2YQSD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H thiamine biosynthesis protein ThiS thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS CMS2_k127_530812_11 563040.Saut_1368 4.043e-144 464.0 COG1565@1|root,COG1565@2|Bacteria,1QNDB@1224|Proteobacteria,42MQ8@68525|delta/epsilon subdivisions,2YNBU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 CMS2_k127_530812_15 563040.Saut_1369 2.58e-129 427.0 COG1538@1|root,COG1538@2|Bacteria,1Q066@1224|Proteobacteria,42RNJ@68525|delta/epsilon subdivisions,2YNZR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS2_k127_530812_6 709032.Sulku_1605 3.61e-187 591.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2YMRT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 CMS2_k127_530812_35 1172190.M947_01815 1.212e-55 205.0 COG0845@1|root,COG0845@2|Bacteria,1QZ27@1224|Proteobacteria,43CEE@68525|delta/epsilon subdivisions,2YTBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - - CMS2_k127_530812_13 929558.SMGD1_2426 1.397e-136 441.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1RD7I@1224|Proteobacteria,42SM8@68525|delta/epsilon subdivisions,2YPEY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Response regulator receiver - - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg CMS2_k127_530812_44 709032.Sulku_1821 2.092e-37 148.0 2ENFG@1|root,33G2V@2|Bacteria,1NPDC@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - OMP_b-brl CMS2_k127_530812_52 1333507.AUTQ01000034_gene3856 2.138e-15 80.0 2EFP1@1|root,339F4@2|Bacteria,1NFZ9@1224|Proteobacteria,1SFAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF600 CMS2_k127_530812_2 929558.SMGD1_0008 0.0 1149.0 COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2YMXW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cytochrome c biogenesis protein ccsBA - - - - - - - - - - - Cytochrom_C_asm,ResB CMS2_k127_530812_1 929558.SMGD1_2447 0.0 1184.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2YMQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 CMS2_k127_530812_46 1122135.KB893135_gene625 5.531e-31 130.0 COG0834@1|root,COG0834@2|Bacteria,1N0VS@1224|Proteobacteria,2U2J2@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 CMS2_k127_530812_28 929558.SMGD1_1138 2.089e-76 259.0 COG1451@1|root,COG1451@2|Bacteria,1RDJ9@1224|Proteobacteria,42RYN@68525|delta/epsilon subdivisions,2YP3T@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Metal-dependent hydrolase - - - ko:K07043 - - - - ko00000 - - - DUF45 CMS2_k127_530812_7 929558.SMGD1_0943 3.333e-185 587.0 COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,42P30@68525|delta/epsilon subdivisions,2YNT6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L radical SAM domain protein - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - CMS2_k127_530812_26 929558.SMGD1_1453 5.307e-90 308.0 COG2199@1|root,COG3706@2|Bacteria,1NC00@1224|Proteobacteria,42MK2@68525|delta/epsilon subdivisions,2YRTJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T diguanylate cyclase - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF CMS2_k127_530812_19 709032.Sulku_1395 2.851e-116 380.0 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2YNUX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Signal transduction protein - - - - - - - - - - - - HDOD CMS2_k127_530812_0 709032.Sulku_1396 0.0 1557.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2YMFT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran CMS2_k127_530812_30 929558.SMGD1_2591 1.854e-72 252.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42R15@68525|delta/epsilon subdivisions,2YNVA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE CMS2_k127_530812_40 1249480.B649_04770 7.025e-46 168.0 COG1886@1|root,COG1886@2|Bacteria,1NNYT@1224|Proteobacteria,42U38@68525|delta/epsilon subdivisions,2YPTT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar motor switch protein fliN - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C CMS2_k127_530812_29 563040.Saut_1059 5.161e-74 258.0 COG3190@1|root,COG3190@2|Bacteria,1Q1CX@1224|Proteobacteria,42PAU@68525|delta/epsilon subdivisions,2YP0B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar - - - - - - - - - - - - - CMS2_k127_530812_53 1282876.BAOK01000001_gene1340 1.092e-08 58.0 COG3576@1|root,COG3576@2|Bacteria,1R8RC@1224|Proteobacteria,2TUXH@28211|Alphaproteobacteria,4BQGF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx CMS2_k127_5331138_8 563040.Saut_0398 1.974e-58 205.0 2C99Z@1|root,2Z9YV@2|Bacteria,1N0B7@1224|Proteobacteria,42P3M@68525|delta/epsilon subdivisions,2YMWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3373) - - - - - - - - - - - - DUF3373 CMS2_k127_5331138_6 563040.Saut_0394 5.839e-80 268.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2YNVV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O bacterioferritin comigratory protein bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA CMS2_k127_5331138_9 929558.SMGD1_1569 2.64e-47 173.0 COG1683@1|root,COG1683@2|Bacteria,1R356@1224|Proteobacteria,43DJ6@68525|delta/epsilon subdivisions,2YPYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF523) - - - - - - - - - - - - DUF523 CMS2_k127_5331138_0 929558.SMGD1_1568 2.928e-242 755.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2YMDS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh CMS2_k127_5331138_7 1537917.JU82_06600 6.263e-61 214.0 COG2346@1|root,COG2346@2|Bacteria,1Q5UZ@1224|Proteobacteria,42U39@68525|delta/epsilon subdivisions,2YPTS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG2346 Truncated hemoglobins - - - ko:K06886 - - - - ko00000 - - - Bac_globin CMS2_k127_5331138_2 929558.SMGD1_1630 1.28e-169 535.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2YMGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 CMS2_k127_5331138_4 563040.Saut_1861 2.183e-144 467.0 COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,42MNX@68525|delta/epsilon subdivisions,2YME9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG0330 Membrane protease subunits stomatin prohibitin homologs - - - - - - - - - - - - Band_7 CMS2_k127_5331138_5 563040.Saut_1860 8.901e-111 362.0 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2YNQD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Histidine biosynthesis bifunctional protein hisIE hisI - 3.5.4.19,3.6.1.31 ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH CMS2_k127_5331138_11 709032.Sulku_0227 1.153e-27 118.0 2AK36@1|root,31ASY@2|Bacteria,1Q62K@1224|Proteobacteria,42W11@68525|delta/epsilon subdivisions,2YQDG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF2393) - - - - - - - - - - - - DUF2393 CMS2_k127_5331138_10 929558.SMGD1_1634 1.641e-43 165.0 2AJSF@1|root,30P8S@2|Bacteria,1PCR0@1224|Proteobacteria,42WCR@68525|delta/epsilon subdivisions,2YSXN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF2393) - - - - - - - - - - - - DUF2393 CMS2_k127_5331138_3 563040.Saut_1857 3.714e-165 523.0 COG1242@1|root,COG1242@2|Bacteria,1MUYF@1224|Proteobacteria,42PX9@68525|delta/epsilon subdivisions,2YN2U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Radical SAM protein - - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C CMS2_k127_5331138_1 1249480.B649_00940 1.821e-222 693.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2YMF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran CMS2_k127_5340897_4 1123279.ATUS01000001_gene935 9.786e-16 87.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1J60U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 CMS2_k127_5340897_0 1165841.SULAR_03332 4.34e-66 249.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - ko:K07184 - - - - ko00000 - - - DUF3488,Transglut_core CMS2_k127_5340897_2 1165841.SULAR_03337 7.777e-39 166.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core,Transglut_i_TM CMS2_k127_5340897_3 574966.KB898656_gene1500 5.47e-36 138.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria,1XKPR@135619|Oceanospirillales 135619|Oceanospirillales O peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3 CMS2_k127_5340897_1 709032.Sulku_1026 1.425e-43 164.0 2AHYJ@1|root,318BT@2|Bacteria,1Q04R@1224|Proteobacteria,42RKI@68525|delta/epsilon subdivisions,2YPAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5358837_13 525898.Sdel_0648 5.527e-13 68.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2YMD3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b CMS2_k127_5358837_1 326298.Suden_0721 1.083e-198 624.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,42N6F@68525|delta/epsilon subdivisions,2YMD6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S 2-nitropropane dioxygenase npd - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO CMS2_k127_5358837_5 1172190.M947_06995 2.018e-126 419.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2YMZ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M N-acetylmuramoyl-L-alanine amidase amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 CMS2_k127_5358837_7 563040.Saut_1609 1.817e-118 406.0 COG2911@1|root,COG2911@2|Bacteria,1NRGB@1224|Proteobacteria,42MD0@68525|delta/epsilon subdivisions,2YMIM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - CMS2_k127_5358837_4 1249480.B649_06880 5.221e-140 452.0 COG2309@1|root,COG2309@2|Bacteria,1R4I5@1224|Proteobacteria 1224|Proteobacteria E aminopeptidase activity - - - - - - - - - - - - - CMS2_k127_5358837_0 760154.Sulba_1005 0.0 1332.0 COG0642@1|root,COG0784@1|root,COG0834@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2YMAM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02030,ko:K07679 ko02020,ko05133,map02020,map05133 M00236,M00477 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.3 - - HATPase_c,HisKA,Response_reg,SBP_bac_3 CMS2_k127_5358837_2 760154.Sulba_1006 3.174e-167 531.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42YRK@68525|delta/epsilon subdivisions,2YRM7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - Response_reg CMS2_k127_5358837_16 1537915.JU57_06140 1.529e-06 50.0 COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,42M9T@68525|delta/epsilon subdivisions,2YNIB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the 'phage' integrase family - - - ko:K14059 - - - - ko00000 - - - Phage_int_SAM_3,Phage_integrase CMS2_k127_5358837_9 709032.Sulku_0708 1.083e-112 368.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2YMVJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase CMS2_k127_5358837_8 204536.SULAZ_1030 5.755e-113 376.0 COG1092@1|root,COG1092@2|Bacteria,2G3I6@200783|Aquificae 200783|Aquificae J PUA domain containing protein - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM CMS2_k127_5358837_11 990073.ATHU01000001_gene301 3.683e-49 181.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,42RE8@68525|delta/epsilon subdivisions,2YP3Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin CMS2_k127_5358837_6 563040.Saut_0427 2.279e-125 408.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,42ME7@68525|delta/epsilon subdivisions,2YMBW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG membrane - - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA CMS2_k127_5358837_10 929558.SMGD1_1072 2.64e-111 364.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2YMHX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Membrane protease subunits - - - - - - - - - - - - Band_7 CMS2_k127_5358837_3 1165841.SULAR_03542 4.961e-156 503.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2YRHY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O NfeD-like C-terminal, partner-binding - - - - - - - - - - - - NfeD CMS2_k127_5358837_12 1165841.SULAR_05508 2.403e-16 78.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2YN92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS2_k127_5360118_0 1123326.JFBL01000018_gene2365 3.824e-237 739.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,42NJ3@68525|delta/epsilon subdivisions,2YNPC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 CMS2_k127_5360118_1 1166018.FAES_2425 6.462e-88 296.0 COG0396@1|root,COG0396@2|Bacteria,4NEMY@976|Bacteroidetes,47N88@768503|Cytophagia 976|Bacteroidetes O TIGRFAM FeS assembly ATPase SufC sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran CMS2_k127_5372424_2 1485544.JQKP01000002_gene1536 1.108e-43 162.0 2B3E9@1|root,31W34@2|Bacteria,1MZ95@1224|Proteobacteria,2VSQX@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5372424_0 563040.Saut_0752 1.324e-165 527.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,42MJ1@68525|delta/epsilon subdivisions,2YMZ8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0212 M20_dimer,Peptidase_M20 CMS2_k127_5372424_1 387092.NIS_1767 9.457e-78 278.0 COG2172@1|root,COG3153@1|root,COG2172@2|Bacteria,COG3153@2|Bacteria,1QXS5@1224|Proteobacteria,43CKS@68525|delta/epsilon subdivisions,2YNB9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase-like ATPase domain - - - - - - - - - - - - Acetyltransf_1,HATPase_c_2 CMS2_k127_5372424_3 1249480.B649_08640 1.99e-32 130.0 COG1331@1|root,COG1331@2|Bacteria,1QZ2A@1224|Proteobacteria,42VGW@68525|delta/epsilon subdivisions,2YQEQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH,Thioredoxin_7 CMS2_k127_5379635_3 387092.NIS_0492 1.083e-169 543.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2YN9H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Ammonium Transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp CMS2_k127_5379635_0 709032.Sulku_2083 0.0 1344.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2YMS4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV CMS2_k127_5379635_12 563040.Saut_0667 3.278e-33 137.0 COG3018@1|root,COG3018@2|Bacteria,1RGG9@1224|Proteobacteria,42P0S@68525|delta/epsilon subdivisions,2YQJK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S (Lipo)protein - - - ko:K09860 - - - - ko00000 - - - LPP20 CMS2_k127_5379635_13 1548151.LS70_04765 3.288e-08 61.0 2BMCT@1|root,32FX0@2|Bacteria,1Q6ED@1224|Proteobacteria,432S3@68525|delta/epsilon subdivisions,2YSGN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5379635_4 1548151.LS70_04770 9.867e-167 534.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2YNF8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains flgR - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat CMS2_k127_5379635_2 929558.SMGD1_2133 1.947e-179 565.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2YMIV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC CMS2_k127_5379635_7 387092.NIS_0487 1.233e-61 216.0 COG2862@1|root,COG2862@2|Bacteria,1RF1A@1224|Proteobacteria,43ACA@68525|delta/epsilon subdivisions,2YT0J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterized protein family, UPF0114 - - - - - - - - - - - - UPF0114 CMS2_k127_5379635_1 326298.Suden_0634 7.206e-209 651.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2YMPG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D CMS2_k127_5379635_11 1255043.TVNIR_1086 4.388e-43 162.0 COG1416@1|root,COG1416@2|Bacteria,1NP3E@1224|Proteobacteria,1SF5I@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE CMS2_k127_5379635_5 1123514.KB905899_gene824 5.202e-151 482.0 COG0725@1|root,COG0725@2|Bacteria,1NACV@1224|Proteobacteria 1224|Proteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 CMS2_k127_5379635_10 697282.Mettu_4178 4.727e-49 186.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,1XFY7@135618|Methylococcales 135618|Methylococcales S Haemolysin-III related - - - - - - - - - - - - HlyIII CMS2_k127_5379635_8 1249480.B649_04440 3.575e-61 225.0 COG4269@1|root,COG4269@2|Bacteria,1MW5P@1224|Proteobacteria,42R97@68525|delta/epsilon subdivisions,2YREG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Bacterial protein of unknown function (DUF898) - - - - - - - - - - - - DUF898 CMS2_k127_5379635_9 243231.GSU0462 3.222e-60 220.0 COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,42TCQ@68525|delta/epsilon subdivisions,2WM2D@28221|Deltaproteobacteria,43S2X@69541|Desulfuromonadales 28221|Deltaproteobacteria O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 CMS2_k127_5379635_6 1537917.JU82_05730 1.277e-119 395.0 COG0731@1|root,COG0731@2|Bacteria,1QG36@1224|Proteobacteria,42M82@68525|delta/epsilon subdivisions,2YN42@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM CMS2_k127_5379635_14 43989.cce_2014 6.767e-05 49.0 COG3950@1|root,COG3950@2|Bacteria,1G6VQ@1117|Cyanobacteria 1117|Cyanobacteria S AAA ATPase domain - - - - - - - - - - - - AAA_15 CMS2_k127_5387175_0 563040.Saut_2156 5.509e-105 341.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2YMZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 CMS2_k127_5387175_1 563040.Saut_2157 7.779e-65 222.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2YN94@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN CMS2_k127_5416024_44 944547.ABLL_0600 4.539e-20 102.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CHE@68525|delta/epsilon subdivisions,2YRKK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HAMP domain - - - - - - - - - - - - HATPase_c CMS2_k127_5416024_37 123214.PERMA_1236 9.258e-61 223.0 COG0715@1|root,COG0715@2|Bacteria,2G53R@200783|Aquificae 200783|Aquificae P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - - CMS2_k127_5416024_38 944547.ABLL_1988 1.05e-57 216.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43AKC@68525|delta/epsilon subdivisions,2YRPM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,Response_reg CMS2_k127_5416024_9 944546.ABED_0428 2.189e-181 586.0 COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,42PB6@68525|delta/epsilon subdivisions,2YTJY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T HD domain - - - - - - - - - - - - HD,PAS_9,Response_reg CMS2_k127_5416024_42 1165841.SULAR_09104 1.315e-23 108.0 COG2199@1|root,COG2203@1|root,COG2204@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,1RGKE@1224|Proteobacteria,43CM2@68525|delta/epsilon subdivisions,2YTK3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GGDEF,PAS_9,Response_reg CMS2_k127_5416024_0 929558.SMGD1_2409 7.311e-314 970.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,42N42@68525|delta/epsilon subdivisions,2YMNR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 CMS2_k127_5416024_34 679926.Mpet_2710 5.382e-65 231.0 COG1712@1|root,arCOG00254@2157|Archaea,2XXKF@28890|Euryarchaeota,2N96R@224756|Methanomicrobia 224756|Methanomicrobia H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate nadX - 1.4.1.21,5.3.3.2 ko:K01823,ko:K06989 ko00760,ko00900,ko01100,ko01110,ko01130,map00760,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123,R07407,R07410 RC00455,RC02566 ko00000,ko00001,ko00002,ko01000 - - - DUF108,NAD_binding_3 CMS2_k127_5416024_33 387092.NIS_1108 2.911e-66 234.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2YP4A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 CMS2_k127_5416024_39 572480.Arnit_2912 7.603e-56 208.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,42NYD@68525|delta/epsilon subdivisions,2YNI5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Permease, YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ CMS2_k127_5416024_24 1249480.B649_04630 1.045e-90 304.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2YP5V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NOU Peptidase A24 pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 CMS2_k127_5416024_23 929558.SMGD1_2848 4.414e-101 333.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2YNEP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf CMS2_k127_5416024_12 929558.SMGD1_2847 7.418e-161 516.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2YMX4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein CMS2_k127_5416024_6 1537917.JU82_04980 7.255e-196 618.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,42N4K@68525|delta/epsilon subdivisions,2YMXB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like CMS2_k127_5416024_22 1172190.M947_06905 5.545e-105 349.0 COG0457@1|root,COG0457@2|Bacteria,1PNM7@1224|Proteobacteria,42ZNV@68525|delta/epsilon subdivisions,2YRNU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TPR repeat - - - - - - - - - - - - - CMS2_k127_5416024_46 357804.Ping_1577 2.213e-13 73.0 COG0578@1|root,COG0578@2|Bacteria,1QYTZ@1224|Proteobacteria,1T3UH@1236|Gammaproteobacteria,2QHEB@267894|Psychromonadaceae 1236|Gammaproteobacteria C FAD dependent oxidoreductase - - - - - - - - - - - - DAO CMS2_k127_5416024_51 666681.M301_0954 1.337e-05 54.0 COG2885@1|root,COG3468@1|root,COG2885@2|Bacteria,COG3468@2|Bacteria,1N6EM@1224|Proteobacteria,2VT3U@28216|Betaproteobacteria,2KM9Q@206350|Nitrosomonadales 206350|Nitrosomonadales MU Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA CMS2_k127_5416024_5 929558.SMGD1_2815 5.397e-202 638.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2YMK9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase CMS2_k127_5416024_16 563040.Saut_1273 4.816e-119 387.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,42PR1@68525|delta/epsilon subdivisions,2YMT0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine motP - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB CMS2_k127_5416024_20 929558.SMGD1_2807 1.048e-108 357.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42Q7D@68525|delta/epsilon subdivisions,2YMSU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Membrane MotB of proton-channel complex MotA/MotB motS - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA CMS2_k127_5416024_21 326298.Suden_1017 1.975e-108 355.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,42NDZ@68525|delta/epsilon subdivisions,2YMJ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP CMS2_k127_5416024_14 563040.Saut_1270 1.036e-146 473.0 COG2265@1|root,COG2265@2|Bacteria,1MY45@1224|Proteobacteria,43BHX@68525|delta/epsilon subdivisions,2YMEI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA) trmA - 2.1.1.35 ko:K00557 - - - - ko00000,ko01000,ko03016 - - - tRNA_U5-meth_tr CMS2_k127_5416024_47 709032.Sulku_1115 2.057e-12 79.0 COG3206@1|root,COG3206@2|Bacteria,1Q68V@1224|Proteobacteria,432MZ@68525|delta/epsilon subdivisions,2YSUM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - - CMS2_k127_5416024_45 443254.Marpi_2037 1.326e-15 88.0 COG5276@1|root,COG5276@2|Bacteria,2GDIA@200918|Thermotogae 200918|Thermotogae S PFAM LVIVD repeat - - - - - - - - - - - - LVIVD CMS2_k127_5416024_36 387093.SUN_1831 6.716e-61 212.0 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2YPC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q CoA-binding protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 CMS2_k127_5416024_10 563040.Saut_1089 1.407e-176 562.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2YMUR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C CMS2_k127_5416024_28 749222.Nitsa_0475 1.489e-77 269.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42QFD@68525|delta/epsilon subdivisions,2YND7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FP Ppx GppA - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA CMS2_k127_5416024_1 709032.Sulku_1488 3.818e-311 960.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2YMQ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H acetolactate synthase ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N CMS2_k127_5416024_32 709032.Sulku_1487 4.268e-69 237.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,42RRU@68525|delta/epsilon subdivisions,2YP7A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E acetolactate synthase ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C CMS2_k127_5416024_19 1172190.M947_00730 1.874e-115 381.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2YMCF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD CMS2_k127_5416024_41 929558.SMGD1_2627 7.923e-28 113.0 2AK1D@1|root,31AQZ@2|Bacteria,1Q5ZH@1224|Proteobacteria,42V6N@68525|delta/epsilon subdivisions,2YQ6B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5416024_7 1249480.B649_05330 1.894e-195 615.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2YN1A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase aspB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_5416024_17 1249480.B649_06400 2.288e-118 383.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2YMH3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E serine acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep CMS2_k127_5416024_2 326298.Suden_1132 8.674e-291 902.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2YMP0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H arginine decarboxylase speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0422 Orn_Arg_deC_N CMS2_k127_5416024_50 387093.SUN_1986 8.413e-06 53.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2YNFI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E COGs COG0069 Glutamate synthase domain 2 - - - - - - - - - - - - Glu_synthase CMS2_k127_5416024_8 563040.Saut_1099 5.848e-186 588.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2YMII@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His CMS2_k127_5416024_49 1471459.JFLJ01000043_gene32 1.748e-10 70.0 COG0125@1|root,COG0125@2|Bacteria,1G52G@1117|Cyanobacteria,1MMBP@1212|Prochloraceae 1117|Cyanobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin CMS2_k127_5416024_29 1537917.JU82_11065 1.144e-74 254.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2YP4R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like CMS2_k127_5416024_30 1172190.M947_00680 4.607e-72 246.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,42QXP@68525|delta/epsilon subdivisions,2YPJE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein CMS2_k127_5416024_43 1249480.B649_06370 5.21e-21 103.0 COG1261@1|root,COG1261@2|Bacteria,1Q3ZV@1224|Proteobacteria,42Y1K@68525|delta/epsilon subdivisions,2YQRI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Chaperone for flagella basal body P-ring formation flgA - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA CMS2_k127_5416024_25 929558.SMGD1_1142 3.774e-85 298.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,42MIH@68525|delta/epsilon subdivisions,2YR84@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction protein containing EAL and modified HD-GYP domains - - - - - - - - - - - - EAL,HDOD CMS2_k127_5416024_31 1120746.CCNL01000005_gene129 4.023e-71 257.0 COG4948@1|root,COG4948@2|Bacteria,2NR7B@2323|unclassified Bacteria 2|Bacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain ykfB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N CMS2_k127_5416024_26 387093.SUN_1175 2.687e-84 292.0 COG5505@1|root,COG5505@2|Bacteria,1MW87@1224|Proteobacteria,42RQH@68525|delta/epsilon subdivisions,2YRCW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF819) - - - - - - - - - - - - DUF819 CMS2_k127_5416024_35 1004149.AFOE01000031_gene460 4.562e-64 227.0 COG3023@1|root,COG3023@2|Bacteria,4NMIV@976|Bacteroidetes,1HY6G@117743|Flavobacteriia 976|Bacteroidetes V N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 CMS2_k127_5416024_18 2340.JV46_04650 2.5e-118 391.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metallophosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos CMS2_k127_5416024_27 709032.Sulku_0999 2.67e-81 277.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,42R50@68525|delta/epsilon subdivisions,2YNX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - - - - - - - - - - MoCF_biosynth CMS2_k127_5416024_13 1123326.JFBL01000006_gene1035 4.81e-155 508.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2YP81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding CMS2_k127_5416024_11 929558.SMGD1_0188 1.864e-170 544.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2YMES@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N CMS2_k127_5416024_4 929558.SMGD1_0187 7.309e-218 697.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2YQUV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Enoyl-CoA hydratase/isomerase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 CMS2_k127_5416024_3 518766.Rmar_1705 2.465e-260 824.0 COG1960@1|root,COG1960@2|Bacteria,4P1V8@976|Bacteroidetes,1FIUE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Domain of unknown function (DUF1974) - - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 CMS2_k127_5416024_15 1123326.JFBL01000006_gene1039 1.257e-141 475.0 COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2YR4S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Acyltransferase,Hydrolase_4 CMS2_k127_5416024_40 572480.Arnit_1898 6.359e-30 121.0 COG2863@1|root,COG2863@2|Bacteria,1NFMX@1224|Proteobacteria,42VGD@68525|delta/epsilon subdivisions,2YPDJ@29547|Epsilonproteobacteria 68525|delta/epsilon subdivisions C cytochrome cyf GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 CMS2_k127_5420114_14 929558.SMGD1_1335 5.188e-21 94.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,42M9K@68525|delta/epsilon subdivisions,2YR2K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - CbiA,GATase_3 CMS2_k127_5420114_3 326298.Suden_0107 5.489e-112 371.0 COG2038@1|root,COG2038@2|Bacteria,1NZFH@1224|Proteobacteria,42NRQ@68525|delta/epsilon subdivisions,2YNQ9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H phosphoribosyltransferase - - - - - - - - - - - - DBI_PRT CMS2_k127_5420114_2 572480.Arnit_1849 1.202e-171 559.0 COG1629@1|root,COG4771@2|Bacteria,1RA71@1224|Proteobacteria,43CIG@68525|delta/epsilon subdivisions,2YTD1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec CMS2_k127_5420114_16 326298.Suden_0119 1.371e-09 63.0 2AYN5@1|root,31QSN@2|Bacteria,1QNBZ@1224|Proteobacteria,4338K@68525|delta/epsilon subdivisions,2YSX9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5420114_11 572480.Arnit_1851 9.139e-56 198.0 2AWDR@1|root,31N9R@2|Bacteria,1QK0X@1224|Proteobacteria,42U4P@68525|delta/epsilon subdivisions,2YPX5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5420114_12 944547.ABLL_1660 4.888e-37 148.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,42QRZ@68525|delta/epsilon subdivisions,2YSXG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin-like domain - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - Thioredoxin_2 CMS2_k127_5420114_0 326298.Suden_2031 0.0 1917.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2YMTE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans CMS2_k127_5420114_9 290402.Cbei_2527 9.208e-61 237.0 COG3287@1|root,COG5001@1|root,COG3287@2|Bacteria,COG5001@2|Bacteria,1UZT7@1239|Firmicutes,24FZE@186801|Clostridia,36IZ1@31979|Clostridiaceae 186801|Clostridia T FIST N domain - - - - - - - - - - - - EAL,FIST,FIST_C,GGDEF CMS2_k127_5420114_1 1163617.SCD_n02361 2.89e-218 694.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_8,PAS_9,SBP_bac_3 CMS2_k127_5420114_4 929558.SMGD1_0712 3.457e-94 320.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42MFV@68525|delta/epsilon subdivisions,2YM95@29547|Epsilonproteobacteria 2|Bacteria KT CHASE2 - - - ko:K07814 - - - - ko00000,ko02022 - - - GAF,HD,Response_reg CMS2_k127_5420114_7 709032.Sulku_0144 1.095e-73 251.0 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,43BC4@68525|delta/epsilon subdivisions,2YMGN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR CMS2_k127_5420114_10 1249480.B649_03140 6.342e-56 213.0 COG0739@1|root,COG0739@2|Bacteria,1N19D@1224|Proteobacteria,42SMK@68525|delta/epsilon subdivisions,2YTS0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 CMS2_k127_5420114_8 1165841.SULAR_09634 2.131e-61 217.0 COG3531@1|root,COG3531@2|Bacteria,1RIN9@1224|Proteobacteria,42ZIN@68525|delta/epsilon subdivisions,2YRQ0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - - ko:K07396 - - - - ko00000 - - - Thioredoxin_5 CMS2_k127_5420114_6 709032.Sulku_0011 1.056e-75 260.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42PA1@68525|delta/epsilon subdivisions,2YNMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_5420114_5 589873.EP13_03520 3.603e-83 303.0 COG2182@1|root,COG3291@1|root,COG2182@2|Bacteria,COG3291@2|Bacteria,1MU3H@1224|Proteobacteria,1RY48@1236|Gammaproteobacteria,464R5@72275|Alteromonadaceae 1236|Gammaproteobacteria G Parallel beta-helix repeats - - - - - - - - - - - - - CMS2_k127_5429661_0 709032.Sulku_0572 6.499e-217 680.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2YMAH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Belongs to the ClpA ClpB family clpB - - ko:K03694,ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N CMS2_k127_5429661_1 929558.SMGD1_0727 4.13e-182 579.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2YN9P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 CMS2_k127_5429661_8 929558.SMGD1_0729 1.964e-29 118.0 COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,42V3S@68525|delta/epsilon subdivisions,2YQ9B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - PurS CMS2_k127_5429661_2 929558.SMGD1_0730 3.312e-114 370.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,42MNY@68525|delta/epsilon subdivisions,2YMTM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 CMS2_k127_5429661_3 929558.SMGD1_0731 2.182e-79 278.0 29W5U@1|root,30HQY@2|Bacteria,1QUJN@1224|Proteobacteria,42NUV@68525|delta/epsilon subdivisions,2YNFP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_5429661_5 709032.Sulku_0386 1.601e-59 213.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2YT8I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase CMS2_k127_5429661_6 929558.SMGD1_0733 3.834e-35 138.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,42V4I@68525|delta/epsilon subdivisions,2YQ1K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB CMS2_k127_5429661_4 709032.Sulku_1048 1.333e-76 261.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,42PC4@68525|delta/epsilon subdivisions,2YP8E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C radicals which are normally produced within the cells and which are toxic to biological systems sodB GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N CMS2_k127_5429661_7 28229.ND2E_3768 4.139e-31 122.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,2Q605@267889|Colwelliaceae 1236|Gammaproteobacteria F SAICAR synthetase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735 SAICAR_synt CMS2_k127_5435527_1 387093.SUN_2055 3.792e-294 912.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2YM7I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0354 DXP_synthase_N,Transket_pyr,Transketolase_C CMS2_k127_5435527_25 563040.Saut_1645 2.157e-59 215.0 COG1317@1|root,COG1317@2|Bacteria,1NJAJ@1224|Proteobacteria,42P5I@68525|delta/epsilon subdivisions,2YQ57@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar assembly protein FliH fliH - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH CMS2_k127_5435527_10 1537917.JU82_07005 1.304e-163 520.0 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,42MS3@68525|delta/epsilon subdivisions,2YM90@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N flagellar motor switch protein fliG GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N CMS2_k127_5435527_3 1537917.JU82_07000 8.029e-226 713.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,42N04@68525|delta/epsilon subdivisions,2YMF6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C CMS2_k127_5435527_11 1537917.JU82_06995 7.454e-158 505.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2YMW7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 CMS2_k127_5435527_9 709032.Sulku_1920 1.832e-166 529.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2YNAN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Chorismate mutase prephenate dehydratase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT CMS2_k127_5435527_4 1537917.JU82_06980 2.225e-203 639.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2YMZM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC CMS2_k127_5435527_17 929558.SMGD1_0751 5.836e-110 366.0 COG0795@1|root,COG0795@2|Bacteria,1PXEK@1224|Proteobacteria,42MVG@68525|delta/epsilon subdivisions,2YN6F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S permease - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ CMS2_k127_5435527_22 563040.Saut_1653 3.566e-70 243.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2YP7I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro CMS2_k127_5435527_20 1537917.JU82_06965 1.572e-81 274.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,42RVM@68525|delta/epsilon subdivisions,2YT8U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C CMS2_k127_5435527_6 709032.Sulku_1926 9.042e-190 600.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2YMC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU twitching motility protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS2_k127_5435527_15 1172190.M947_02820 2.284e-122 400.0 COG0176@1|root,COG0176@2|Bacteria,1N9G3@1224|Proteobacteria,42MCK@68525|delta/epsilon subdivisions,2YMRY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA CMS2_k127_5435527_7 326298.Suden_1998 1.722e-181 586.0 28J7E@1|root,2Z92U@2|Bacteria,1NAE1@1224|Proteobacteria,42P08@68525|delta/epsilon subdivisions,2YNTD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 CMS2_k127_5435527_23 326298.Suden_1997 2.652e-66 228.0 2DMP9@1|root,32SV1@2|Bacteria,1N17Y@1224|Proteobacteria,42TQF@68525|delta/epsilon subdivisions,2YQ0W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3015) - - - - - - - - - - - - DUF3015 CMS2_k127_5435527_18 1537917.JU82_06940 2.291e-84 284.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2YNZB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans CMS2_k127_5435527_0 709032.Sulku_1931 0.0 1028.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2YMF5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent CLP protease ATP-binding subunit clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N CMS2_k127_5435527_28 563040.Saut_1749 2.888e-37 142.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2YPT8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS CMS2_k127_5435527_5 1249480.B649_09230 1.437e-190 602.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,42MVB@68525|delta/epsilon subdivisions,2YNU4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E O-acetylhomoserine sulfhydrylase - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP CMS2_k127_5435527_24 1355374.JARU01000016_gene964 8.6e-60 213.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,42SQE@68525|delta/epsilon subdivisions,2YPHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0003674,GO:0003824,GO:0004141,GO:0016874,GO:0016879,GO:0016882 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 CMS2_k127_5435527_13 563040.Saut_1659 3.863e-149 475.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2YN8M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N CMS2_k127_5435527_16 563040.Saut_1658 8.062e-119 392.0 COG0147@1|root,COG0147@2|Bacteria,1R5Y8@1224|Proteobacteria,42P2B@68525|delta/epsilon subdivisions,2YMFR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH component I pabB - 2.6.1.85 ko:K01665 ko00790,map00790 - R01716 RC00010,RC01418 ko00000,ko00001,ko01000 - - - Chorismate_bind CMS2_k127_5435527_29 1150621.SMUL_0521 2.361e-32 129.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42U8Y@68525|delta/epsilon subdivisions,2YQ22@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 CMS2_k127_5435527_19 1123326.JFBL01000011_gene188 1.572e-81 276.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2YMUT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 CMS2_k127_5435527_2 1123326.JFBL01000011_gene187 7.547e-229 722.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2YMSC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa CMS2_k127_5435527_26 1123326.JFBL01000011_gene186 5.195e-51 185.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42SRI@68525|delta/epsilon subdivisions,2YQ7X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NADH-quinone oxidoreductase nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx CMS2_k127_5435527_8 1123326.JFBL01000011_gene185 1.298e-167 537.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2YNE6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Oxidoreductase nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB CMS2_k127_5435527_14 572480.Arnit_2658 3.652e-143 471.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2YNNW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,NADH-G_4Fe-4S_3 CMS2_k127_5435527_12 1123326.JFBL01000011_gene177 2.185e-152 492.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2YMNX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh CMS2_k127_5435527_21 1442598.JABW01000005_gene559 1.105e-76 259.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42T2H@68525|delta/epsilon subdivisions,2YPIS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_7 CMS2_k127_5435527_27 1150621.SMUL_0511 1.721e-43 164.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42UNF@68525|delta/epsilon subdivisions,2YQFG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 CMS2_k127_5435527_30 1150621.SMUL_0512 4.174e-20 92.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2YQEW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 CMS2_k127_546610_8 1249480.B649_00580 1.486e-34 133.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2YMQ1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N CMS2_k127_546610_0 929558.SMGD1_2863 3.675e-233 728.0 COG0348@1|root,COG0348@2|Bacteria,1PYK0@1224|Proteobacteria,42Y5A@68525|delta/epsilon subdivisions,2YRHT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 CMS2_k127_546610_3 944547.ABLL_1446 1.574e-191 620.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria 1224|Proteobacteria P Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec CMS2_k127_546610_11 1448857.JFAP01000001_gene1057 8.904e-13 74.0 29W5T@1|root,30HQX@2|Bacteria,1QUJD@1224|Proteobacteria,42XC1@68525|delta/epsilon subdivisions,2YQYF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S TOBE domain - - - - - - - - - - - - TOBE CMS2_k127_546610_6 563040.Saut_1952 3.536e-108 354.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,42NZV@68525|delta/epsilon subdivisions,2YN88@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter permease modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 CMS2_k127_546610_5 1150621.SMUL_2413 6.554e-119 388.0 COG3842@1|root,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,42MSG@68525|delta/epsilon subdivisions,2YMX7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E ATP-binding protein modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran CMS2_k127_546610_4 1123514.KB905903_gene350 2.966e-134 453.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RZKN@1236|Gammaproteobacteria 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,PAS_9 CMS2_k127_546610_1 1165841.SULAR_02953 2.139e-214 678.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2YN4S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans CMS2_k127_546610_9 709032.Sulku_1075 1.086e-20 95.0 2BPZI@1|root,32ITJ@2|Bacteria,1PBV9@1224|Proteobacteria,42VR5@68525|delta/epsilon subdivisions,2YQJA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_546610_2 1123326.JFBL01000001_gene1466 1.997e-204 654.0 COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,42PSI@68525|delta/epsilon subdivisions 1224|Proteobacteria O PFAM peptidase M48 Ste24p htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 CMS2_k127_546610_7 1123326.JFBL01000001_gene1467 2.904e-78 266.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42S15@68525|delta/epsilon subdivisions 1224|Proteobacteria S PFAM LemA family protein lemA - - ko:K03744 - - - - ko00000 - - - LemA CMS2_k127_547504_0 1249480.B649_03330 1.543e-247 768.0 COG0045@1|root,COG0045@2|Bacteria,1PYM0@1224|Proteobacteria,42NR1@68525|delta/epsilon subdivisions,2YMG6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the succinate malate CoA ligase beta subunit family - - 2.3.3.8 ko:K15231 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Citrate_bind CMS2_k127_547504_1 929558.SMGD1_1941 1.83e-32 126.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria,1MUGA@1224|Proteobacteria,42NI0@68525|delta/epsilon subdivisions,2YNKI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H ATP citrate synthase - - 2.3.3.8 ko:K15230 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,Ligase_CoA CMS2_k127_5534341_5 929558.SMGD1_2271 1.384e-67 233.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2YMRV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt CMS2_k127_5534341_0 563040.Saut_0776 2.272e-274 847.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2YMA9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N CMS2_k127_5534341_7 1249480.B649_08285 5.185e-47 172.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2YPWF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N CMS2_k127_5534341_3 1249480.B649_08280 5.956e-70 241.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2YNC3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U MotA TolQ ExbB proton channel family tolQ - - - - - - - - - - - MotA_ExbB CMS2_k127_5534341_8 1537917.JU82_04660 1.598e-45 168.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2YPZU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U transport protein tolR - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD CMS2_k127_5534341_10 1172190.M947_09100 7.215e-20 98.0 COG0810@1|root,COG0810@2|Bacteria,1QAAM@1224|Proteobacteria,42X9R@68525|delta/epsilon subdivisions,2YQQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2 CMS2_k127_5534341_1 929558.SMGD1_2277 3.946e-160 514.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2YMQG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N CMS2_k127_5534341_9 1537917.JU82_03790 8.811e-44 162.0 COG2199@1|root,COG3706@2|Bacteria,1QUJM@1224|Proteobacteria,42TUI@68525|delta/epsilon subdivisions,2YPSC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Response regulator receiver - - - ko:K07814 - - - - ko00000,ko02022 - - - Response_reg CMS2_k127_5534341_4 929558.SMGD1_0291 1.145e-67 246.0 COG0784@1|root,COG0784@2|Bacteria,1Q9XN@1224|Proteobacteria,42YUB@68525|delta/epsilon subdivisions,2YRFD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg CMS2_k127_5534341_2 1165841.SULAR_04392 6.187e-128 418.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,42Z0J@68525|delta/epsilon subdivisions 1224|Proteobacteria H coproporphyrinogen III oxidase hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760 Coprogen_oxidas CMS2_k127_5534341_6 709032.Sulku_1402 5.258e-65 227.0 COG3148@1|root,COG3148@2|Bacteria,1MZCN@1224|Proteobacteria,42S7K@68525|delta/epsilon subdivisions,2YPB2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Dtw domain containing protein - - - - - - - - - - - - DTW CMS2_k127_5549127_1 537970.HCAN_1482 1.592e-15 79.0 COG2740@1|root,COG2740@2|Bacteria,1Q3GD@1224|Proteobacteria,42XA3@68525|delta/epsilon subdivisions,2YQQ2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K nucleic-acid-binding protein implicated in transcription termination - - - - - - - - - - - - DUF448 CMS2_k127_5549127_0 709032.Sulku_0460 6.193e-66 237.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2YM9V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N CMS2_k127_5748980_0 522772.Dacet_0548 4.197e-127 413.0 COG3328@1|root,COG3328@2|Bacteria,2GGBW@200930|Deferribacteres 2|Bacteria L PFAM transposase mutator type - - - ko:K07493 - - - - ko00000 - - - Transposase_mut CMS2_k127_5765201_1 1047013.AQSP01000046_gene1784 1.011e-08 56.0 COG2801@1|root,COG2801@2|Bacteria,2NQ28@2323|unclassified Bacteria 2|Bacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 CMS2_k127_5765201_0 1535422.ND16A_2082 6.594e-93 320.0 COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1RSMZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L PFAM Integrase - - - - - - - - - - - - - CMS2_k127_6055937_1 452637.Oter_4175 7.715e-14 75.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46VB0@74201|Verrucomicrobia,3K8AK@414999|Opitutae 414999|Opitutae KLT serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase CMS2_k127_6055937_0 1123242.JH636435_gene2023 3.8e-64 225.0 COG1595@1|root,COG1595@2|Bacteria,2IZAB@203682|Planctomycetes 203682|Planctomycetes K COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog - - - - - - - - - - - - Sigma70_ECF CMS2_k127_6104211_9 709032.Sulku_0482 1.472e-08 55.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2YN0Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans CMS2_k127_6104211_8 1280689.AUJC01000003_gene953 1.317e-17 90.0 28NJ8@1|root,2ZBKG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - CMS2_k127_6104211_7 1249480.B649_10640 8.24e-32 126.0 COG1677@1|root,COG1677@2|Bacteria,1NIFD@1224|Proteobacteria,42V59@68525|delta/epsilon subdivisions,2YQF1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE CMS2_k127_6104211_3 563040.Saut_0330 5.31e-76 257.0 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,42TPI@68525|delta/epsilon subdivisions,2YP1Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C CMS2_k127_6104211_6 1249480.B649_10630 1.847e-48 177.0 COG1815@1|root,COG1815@2|Bacteria,1PSBA@1224|Proteobacteria,42VSQ@68525|delta/epsilon subdivisions,2YPMD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body - - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod CMS2_k127_6104211_1 1537917.JU82_01595 1.331e-167 534.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2YMJH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE CMS2_k127_6104211_2 709032.Sulku_2246 7.165e-111 370.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2YMI9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 CMS2_k127_6104211_4 1537917.JU82_06680 1.371e-69 241.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2YMZV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM SNARE associated Golgi protein dedA - - - - - - - - - - - SNARE_assoc CMS2_k127_6104211_0 1249480.B649_10520 0.0 1271.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2YMJM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD CMS2_k127_6104211_5 563040.Saut_1885 1.224e-60 214.0 COG5615@1|root,COG5615@2|Bacteria,1Q1AZ@1224|Proteobacteria,42T6C@68525|delta/epsilon subdivisions,2YPN6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S integral membrane protein - - - - - - - - - - - - - CMS2_k127_6127055_10 572480.Arnit_1615 3.101e-22 98.0 COG2195@1|root,COG2195@2|Bacteria,1MUWK@1224|Proteobacteria,42PS0@68525|delta/epsilon subdivisions,2YMQC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Dipeptidase pepD - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M20 CMS2_k127_6127055_15 1379281.AVAG01000018_gene1049 1.243e-06 56.0 2EDD9@1|root,3379K@2|Bacteria,1NKEJ@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3568) - - - - - - - - - - - - DUF3568 CMS2_k127_6127055_5 1537917.JU82_09785 8.621e-107 349.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42N6I@68525|delta/epsilon subdivisions,2YN8H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD CMS2_k127_6127055_0 1537917.JU82_09780 8.063e-225 714.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42YH8@68525|delta/epsilon subdivisions,2YRAU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg CMS2_k127_6127055_2 1537917.JU82_09775 4.601e-154 508.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase mmoS - - ko:K20972 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,CHASE5,HATPase_c,HisKA,Hpt,Response_reg CMS2_k127_6127055_6 1249480.B649_03125 1.042e-95 320.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,43B2E@68525|delta/epsilon subdivisions,2YN33@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M peptidylprolyl isomerase peb4 - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 CMS2_k127_6127055_7 314345.SPV1_11656 2.821e-82 282.0 COG2515@1|root,COG2515@2|Bacteria,1R87T@1224|Proteobacteria 1224|Proteobacteria E 1-aminocyclopropane-1-carboxylate deaminase acd - 3.5.99.7 ko:K01505 ko00270,map00270 - R00997 RC00419 ko00000,ko00001,ko01000 - - - PALP CMS2_k127_6127055_1 1537917.JU82_09765 1.64e-200 628.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2YMEQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G fructose-bisphosphate aldolase fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase CMS2_k127_6127055_4 102129.Lepto7375DRAFT_6767 2.216e-125 407.0 2BVW3@1|root,2Z7TB@2|Bacteria,1G5I8@1117|Cyanobacteria 1117|Cyanobacteria S PFAM 5'-nucleotidase - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5-nucleotidase CMS2_k127_6127055_8 929558.SMGD1_2553 2.083e-46 184.0 COG0739@1|root,COG0739@2|Bacteria,1N19D@1224|Proteobacteria,42SMK@68525|delta/epsilon subdivisions,2YTS0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 CMS2_k127_6127055_13 187272.Mlg_0164 4.237e-11 65.0 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria 1236|Gammaproteobacteria T GGDEF domain - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,CHASE4,GGDEF,PAS_9 CMS2_k127_6127055_3 1165841.SULAR_02463 9.652e-130 425.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2YMC1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU twitching motility protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE CMS2_k127_6127055_11 760142.Hipma_0739 6.903e-17 85.0 2DPPU@1|root,332X8@2|Bacteria,1NEQU@1224|Proteobacteria,42WQG@68525|delta/epsilon subdivisions,2WS6T@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6127055_12 929558.SMGD1_0780 5.005e-13 71.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,42SJ8@68525|delta/epsilon subdivisions,2YNWU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB - - ko:K03664 - - - - ko00000 - - - SmpB CMS2_k127_6127055_9 563192.HMPREF0179_02175 7.735e-24 104.0 COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,42VFI@68525|delta/epsilon subdivisions,2WR7C@28221|Deltaproteobacteria,2MF8M@213115|Desulfovibrionales 28221|Deltaproteobacteria S Cupin domain - - - ko:K11312 - - - - ko00000 - - - Cupin_2 CMS2_k127_6127055_14 667014.Thein_2135 1.718e-08 59.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - TraF_2 CMS2_k127_6131994_5 1249480.B649_10655 1.154e-74 254.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2YMKA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase CMS2_k127_6131994_0 563040.Saut_0328 2.006e-232 734.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2YMJ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell division protein FtsI penicillin-binding protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase CMS2_k127_6131994_6 929558.SMGD1_2517 2.963e-57 204.0 2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,42WCG@68525|delta/epsilon subdivisions 1224|Proteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 CMS2_k127_6131994_2 1537917.JU82_05680 7.552e-118 387.0 COG0500@1|root,COG2226@2|Bacteria,1NV27@1224|Proteobacteria,42P39@68525|delta/epsilon subdivisions,2YNRW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_31 CMS2_k127_6131994_8 1283284.AZUK01000001_gene870 8.383e-46 176.0 2EFNH@1|root,339EN@2|Bacteria,1NNV3@1224|Proteobacteria,1SINQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6131994_9 1249480.B649_10640 8.994e-33 129.0 COG1677@1|root,COG1677@2|Bacteria,1NIFD@1224|Proteobacteria,42V59@68525|delta/epsilon subdivisions,2YQF1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE CMS2_k127_6131994_4 563040.Saut_0330 3.526e-75 255.0 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,42TPI@68525|delta/epsilon subdivisions,2YP1Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C CMS2_k127_6131994_7 1249480.B649_10630 1.479e-49 180.0 COG1815@1|root,COG1815@2|Bacteria,1PSBA@1224|Proteobacteria,42VSQ@68525|delta/epsilon subdivisions,2YPMD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body - - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod CMS2_k127_6131994_1 1537917.JU82_01595 3.37e-170 541.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2YMJH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE CMS2_k127_6131994_3 709032.Sulku_2246 2.44e-114 381.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2YMI9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 CMS2_k127_6131994_10 1537917.JU82_06680 3.872e-32 128.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2YMZV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM SNARE associated Golgi protein dedA - - - - - - - - - - - SNARE_assoc CMS2_k127_6164841_12 563040.Saut_0548 6.776e-91 303.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2YMF2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,UPF0004 CMS2_k127_6164841_11 929558.SMGD1_1802 9.852e-98 330.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2YMRR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3 CMS2_k127_6164841_26 1249480.B649_01320 1.788e-47 176.0 2AIHQ@1|root,318ZM@2|Bacteria,1Q19H@1224|Proteobacteria,42T48@68525|delta/epsilon subdivisions,2YPGP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6164841_24 709032.Sulku_0300 3.712e-50 183.0 COG3166@1|root,COG3166@2|Bacteria,1Q1VC@1224|Proteobacteria,42UGS@68525|delta/epsilon subdivisions,2YPY1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU PFAM Fimbrial assembly family protein - - - - - - - - - - - - - CMS2_k127_6164841_21 929558.SMGD1_1799 3.023e-62 228.0 2BQX9@1|root,32JUG@2|Bacteria,1Q2H0@1224|Proteobacteria,42VPF@68525|delta/epsilon subdivisions,2YQMK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6164841_10 563040.Saut_0543 2.743e-100 335.0 COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42RBN@68525|delta/epsilon subdivisions,2YP23@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Belongs to the 'phage' integrase family - - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase CMS2_k127_6164841_19 1249480.B649_01300 5.104e-71 246.0 COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42RJM@68525|delta/epsilon subdivisions,2YP5P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K09778 - - - - ko00000 - - - DUF374 CMS2_k127_6164841_1 1537917.JU82_09970 5.204e-222 695.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,42MQ3@68525|delta/epsilon subdivisions,2YMPC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 CMS2_k127_6164841_31 709032.Sulku_0295 7.405e-28 114.0 29H9G@1|root,30470@2|Bacteria,1QR1D@1224|Proteobacteria,42TWI@68525|delta/epsilon subdivisions,2YPSP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6164841_4 563040.Saut_0538 3.158e-163 521.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2YMJW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N CMS2_k127_6164841_3 203119.Cthe_3075 4.794e-164 537.0 COG2304@1|root,COG2304@2|Bacteria,1TSU7@1239|Firmicutes,249KV@186801|Clostridia,3WGCX@541000|Ruminococcaceae 186801|Clostridia S Von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A CMS2_k127_6164841_32 1165841.SULAR_10674 1.732e-21 97.0 2DDD8@1|root,2ZHK8@2|Bacteria,1Q56G@1224|Proteobacteria,42V7B@68525|delta/epsilon subdivisions,2YQI8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulphur oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ CMS2_k127_6164841_6 563040.Saut_0537 4.602e-142 456.0 COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2YMX1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P ABC transporter permease nikY - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 CMS2_k127_6164841_18 563040.Saut_0349 1.55e-71 246.0 COG0357@1|root,COG0357@2|Bacteria,1NAFK@1224|Proteobacteria,43B6H@68525|delta/epsilon subdivisions,2YT64@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA gidB - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB CMS2_k127_6164841_17 1172190.M947_07535 1.459e-80 277.0 COG1397@1|root,COG1397@2|Bacteria,1RA82@1224|Proteobacteria,42QPD@68525|delta/epsilon subdivisions,2YRPN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH CMS2_k127_6164841_28 929558.SMGD1_0575 2.272e-35 136.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2YPTZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K 'Cold-shock' DNA-binding domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD CMS2_k127_6164841_30 929558.SMGD1_1141 1.307e-28 115.0 COG4895@1|root,COG4895@2|Bacteria,1N7TD@1224|Proteobacteria,42V1D@68525|delta/epsilon subdivisions,2YQJ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Uncharacterized conserved protein (DUF2196) - - - - - - - - - - - - DUF2196 CMS2_k127_6164841_20 387093.SUN_1098 4.212e-63 220.0 2BEW6@1|root,328MU@2|Bacteria,1QAUA@1224|Proteobacteria,42VY6@68525|delta/epsilon subdivisions,2YQED@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6164841_23 123214.PERMA_0031 3.493e-58 211.0 COG1028@1|root,COG1028@2|Bacteria,2G4UB@200783|Aquificae 200783|Aquificae IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - adh_short CMS2_k127_6164841_13 1165841.SULAR_03133 4.335e-90 304.0 COG0676@1|root,COG0676@2|Bacteria,1Q7VN@1224|Proteobacteria,42SFK@68525|delta/epsilon subdivisions,2YPP5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Belongs to the glucose-6-phosphate 1-epimerase family - - 5.1.3.15 ko:K01792 ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130 - R02739 RC00563 ko00000,ko00001,ko01000 - - - Aldose_epim CMS2_k127_6164841_16 929558.SMGD1_1267 1.215e-82 291.0 COG0025@1|root,COG0025@2|Bacteria,1QHRZ@1224|Proteobacteria,42RU2@68525|delta/epsilon subdivisions,2YPAV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0025 NhaP-type Na H and K H - - - ko:K03316 - - - - ko00000 2.A.36 - - GGDEF,Na_H_Exchanger CMS2_k127_6164841_2 1172190.M947_02070 3.254e-195 628.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42P0K@68525|delta/epsilon subdivisions,2YND1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT MCP-domain signal transduction protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal CMS2_k127_6164841_7 1071679.BG57_24525 1.388e-135 447.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K43J@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the DEAD box helicase family dbpA GO:0000339,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006412,GO:0006413,GO:0006518,GO:0006725,GO:0006807,GO:0008026,GO:0008135,GO:0008150,GO:0008152,GO:0008186,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0010501,GO:0016070,GO:0016281,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0042623,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0060255,GO:0065007,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 3.6.4.13 ko:K05591 - - - - ko00000,ko01000,ko03009 - - - DEAD,DbpA,Helicase_C CMS2_k127_6164841_0 929558.SMGD1_0013 5.171e-234 745.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42P9M@68525|delta/epsilon subdivisions,2YNH7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CZB,HAMP,MCPsignal,dCache_3 CMS2_k127_6164841_25 1448857.JFAP01000001_gene977 7.85e-48 179.0 COG1266@1|root,COG1266@2|Bacteria,1RFHC@1224|Proteobacteria,42VZB@68525|delta/epsilon subdivisions,2YR3V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S CAAX protease self-immunity - - - - - - - - - - - - Abi CMS2_k127_6164841_5 357804.Ping_2455 6.51e-144 472.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N CMS2_k127_6164841_15 357804.Ping_2456 2.341e-84 286.0 COG3021@1|root,COG3021@2|Bacteria,1MVPP@1224|Proteobacteria,1RMBH@1236|Gammaproteobacteria,2QJ6J@267894|Psychromonadaceae 1236|Gammaproteobacteria L Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos CMS2_k127_6164841_8 326298.Suden_1692 4.958e-125 407.0 COG0535@1|root,COG0535@2|Bacteria,1N2I6@1224|Proteobacteria,42P9K@68525|delta/epsilon subdivisions,2YNK6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Radical SAM - - - - - - - - - - - - Radical_SAM,SPASM CMS2_k127_6164841_22 1366050.N234_35130 6.324e-62 220.0 COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,2VN2K@28216|Betaproteobacteria,1K7D3@119060|Burkholderiaceae 28216|Betaproteobacteria P Iron/manganese superoxide dismutases, C-terminal domain - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Rhodanese,Sod_Fe_C CMS2_k127_6164841_14 929558.SMGD1_1450 1.523e-86 288.0 COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,42QRY@68525|delta/epsilon subdivisions,2YRU2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S YaeQ - - - - - - - - - - - - YaeQ CMS2_k127_6164841_29 572480.Arnit_1983 3.525e-33 129.0 COG1092@1|root,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria,42Q87@68525|delta/epsilon subdivisions,2YNGM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the methyltransferase superfamily - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM CMS2_k127_6182668_1 563040.Saut_0388 1.352e-61 216.0 2AI7Y@1|root,318NF@2|Bacteria,1Q0NR@1224|Proteobacteria,42SAU@68525|delta/epsilon subdivisions,2YPMQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6182668_0 929558.SMGD1_1699 3.083e-126 409.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,42MXH@68525|delta/epsilon subdivisions,2YMN3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H 4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA CMS2_k127_6182668_2 1353529.M899_1094 9.601e-46 175.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2MTD2@213481|Bdellovibrionales,2WNGS@28221|Deltaproteobacteria 213481|Bdellovibrionales S of the alpha beta superfamily - - - ko:K06889 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4 CMS2_k127_6209864_1 317025.Tcr_1803 9.804e-125 402.0 COG0491@1|root,COG0491@2|Bacteria,1PHBX@1224|Proteobacteria,1S357@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metallo-beta-lactamase superfamily - - 3.1.1.81 ko:K13075 ko02024,map02024 - R08970 RC00713 ko00000,ko00001,ko01000 - - - Lactamase_B CMS2_k127_6209864_0 1123514.KB905899_gene1365 2.589e-131 426.0 COG3239@1|root,COG3239@2|Bacteria,1P79B@1224|Proteobacteria,1RNY0@1236|Gammaproteobacteria,4624H@72273|Thiotrichales 72273|Thiotrichales I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase CMS2_k127_6209864_2 1150621.SMUL_2951 7.587e-112 363.0 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,42QUI@68525|delta/epsilon subdivisions,2YP0W@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 CMS2_k127_6213641_0 1249480.B649_06535 1.493e-206 645.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,42MMI@68525|delta/epsilon subdivisions,2YNPZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitrogenase protein alpha chain - - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro CMS2_k127_6213641_3 1537917.JU82_04995 3.095e-36 140.0 2BS4Z@1|root,32M5X@2|Bacteria,1Q34G@1224|Proteobacteria,42WRS@68525|delta/epsilon subdivisions,2YQC8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6213641_1 990073.ATHU01000001_gene1787 3.374e-170 538.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,42NE5@68525|delta/epsilon subdivisions,2YNF7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH CMS2_k127_6213641_2 990073.ATHU01000001_gene1786 2.87e-58 205.0 COG0454@1|root,COG4886@1|root,COG0456@2|Bacteria,COG4886@2|Bacteria,1Q94S@1224|Proteobacteria,42X59@68525|delta/epsilon subdivisions,2YQUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KLT COG4886 Leucine-rich repeat (LRR) protein - - - - - - - - - - - - LRR_4,LRR_8,Pkinase CMS2_k127_6227108_2 1249480.B649_08310 3.689e-42 160.0 COG0711@1|root,COG0711@2|Bacteria,1Q9TP@1224|Proteobacteria,42U87@68525|delta/epsilon subdivisions,2YPT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B CMS2_k127_6227108_1 563040.Saut_0773 2.96e-49 181.0 COG0712@1|root,COG0712@2|Bacteria,1RFPY@1224|Proteobacteria,42SKR@68525|delta/epsilon subdivisions,2YPHX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP CMS2_k127_6227108_0 563040.Saut_0774 4.589e-290 895.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2YMSF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iIT341.HP1134 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N CMS2_k127_6235824_4 933262.AXAM01000059_gene2916 1.288e-80 291.0 COG0642@1|root,COG3221@1|root,COG4251@1|root,COG0642@2|Bacteria,COG3221@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43CDW@68525|delta/epsilon subdivisions,2X8IN@28221|Deltaproteobacteria,2MPP7@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - CHASE4,HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg CMS2_k127_6235824_0 1122947.FR7_2357 4.736e-150 490.0 COG3437@1|root,COG3437@2|Bacteria,1UYCB@1239|Firmicutes,4H2H0@909932|Negativicutes 909932|Negativicutes T SMART metal-dependent phosphohydrolase, HD region - - - - - - - - - - - - DUF3369,HD,Response_reg CMS2_k127_6235824_1 563040.Saut_1743 6.071e-114 371.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2YMWV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA CMS2_k127_6235824_5 1249480.B649_09365 4.432e-57 201.0 COG2198@1|root,COG2198@2|Bacteria,1Q0HI@1224|Proteobacteria,42S4B@68525|delta/epsilon subdivisions,2YP8X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - Hpt CMS2_k127_6235824_2 929558.SMGD1_1829 1.407e-113 372.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2YMU9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf CMS2_k127_6235824_3 1537917.JU82_00790 1.062e-87 291.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2YMR8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N CMS2_k127_6236726_19 1288826.MSNKSG1_00531 5.406e-24 108.0 COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria,1S4NA@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B,OSCP CMS2_k127_6236726_3 1131553.JIBI01000039_gene1942 5.364e-196 622.0 COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,2VPGJ@28216|Betaproteobacteria,3728R@32003|Nitrosomonadales 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA2 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N CMS2_k127_6236726_15 697282.Mettu_0377 7.305e-44 170.0 COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria,1XF9U@135618|Methylococcales 135618|Methylococcales C ATP synthase - - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt CMS2_k127_6236726_6 1123518.ARWI01000001_gene2221 4.993e-138 458.0 COG2199@1|root,COG4564@1|root,COG3706@2|Bacteria,COG4564@2|Bacteria,1MX83@1224|Proteobacteria,1RMRP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3,PAS_4,PAS_9,dCache_1 CMS2_k127_6236726_0 929558.SMGD1_1129 0.0 1069.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,42M9U@68525|delta/epsilon subdivisions,2YNJP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K RNA binding S1 domain protein - - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF CMS2_k127_6236726_21 387093.SUN_0758 1.406e-17 84.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2YMAM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg CMS2_k127_6236726_4 929558.SMGD1_2597 3.62e-187 590.0 COG1979@1|root,COG1979@2|Bacteria,1QUBJ@1224|Proteobacteria,42MPI@68525|delta/epsilon subdivisions,2YMD7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C dehydrogenase - - - ko:K08325 ko00640,map00640 - R02528 RC00739 ko00000,ko00001,ko01000 - - - Fe-ADH CMS2_k127_6236726_14 929558.SMGD1_0132 3.375e-54 214.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - ko:K03090,ko:K03409 ko02030,map02030 - - - ko00000,ko00001,ko02035,ko03021 - - - CHASE,CheX,GAF,GGDEF,PAS_8,Response_reg,cNMP_binding CMS2_k127_6236726_10 395494.Galf_1544 2.163e-93 315.0 COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2VR36@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB CMS2_k127_6236726_17 929558.SMGD1_2403 9.573e-35 136.0 COG1734@1|root,COG1734@2|Bacteria,1N7D8@1224|Proteobacteria,42VPI@68525|delta/epsilon subdivisions,2YQRE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Prokaryotic dksA/traR C4-type zinc finger - - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR CMS2_k127_6236726_16 563040.Saut_0413 1.312e-39 151.0 COG1959@1|root,COG1959@2|Bacteria,1PC6Q@1224|Proteobacteria,42VG6@68525|delta/epsilon subdivisions,2YQBX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 CMS2_k127_6236726_12 709032.Sulku_2592 1.177e-72 247.0 COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,42WEW@68525|delta/epsilon subdivisions 1224|Proteobacteria C cytochrome c norC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 - - Cytochrom_C CMS2_k127_6236726_2 709032.Sulku_2593 1.435e-243 757.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2YMKZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitric oxide reductase norZ - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 CMS2_k127_6236726_1 709032.Sulku_2594 7.719e-250 783.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,42P8Y@68525|delta/epsilon subdivisions,2YRE9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG4548 Nitric oxide reductase activation protein - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - VWA CMS2_k127_6236726_5 1249480.B649_06245 1.675e-142 454.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,42MX4@68525|delta/epsilon subdivisions,2YRKU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG0714 MoxR-like - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C CMS2_k127_6236726_18 929558.SMGD1_0340 3.617e-33 132.0 COG2143@1|root,COG2143@2|Bacteria 2|Bacteria O COG2143 Thioredoxin-related protein soxS - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - Thioredoxin_2,Thioredoxin_7 CMS2_k127_6236726_8 1121918.ARWE01000001_gene3165 1.525e-112 366.0 COG0500@1|root,COG0500@2|Bacteria,1QZTX@1224|Proteobacteria,42WZK@68525|delta/epsilon subdivisions 1224|Proteobacteria Q Methyltransferase domain - - - - - - - - - - - - TPMT CMS2_k127_6236726_7 1537917.JU82_00720 9.881e-127 412.0 COG1672@1|root,COG1672@2|Bacteria,1PZGT@1224|Proteobacteria,42QN9@68525|delta/epsilon subdivisions,2YNKC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Archaea bacterial proteins of unknown function - - - ko:K06921 - - - - ko00000 - - - DUF234 CMS2_k127_6236726_23 1123517.JOMR01000001_gene1020 1.221e-09 63.0 COG2010@1|root,COG2010@2|Bacteria,1N71Z@1224|Proteobacteria,1SH2C@1236|Gammaproteobacteria,461FB@72273|Thiotrichales 72273|Thiotrichales C Cytochrome c - - - - - - - - - - - - - CMS2_k127_6236726_22 1172190.M947_08995 9.115e-14 76.0 COG1331@1|root,COG1331@2|Bacteria,1QZ2A@1224|Proteobacteria,42VGW@68525|delta/epsilon subdivisions,2YQEQ@29547|Epsilonproteobacteria 1224|Proteobacteria O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH,Thioredoxin_7 CMS2_k127_6236726_13 159087.Daro_1929 1.751e-62 222.0 COG0607@1|root,COG0607@2|Bacteria,1R8XX@1224|Proteobacteria,2VQ1D@28216|Betaproteobacteria,2KYZN@206389|Rhodocyclales 206389|Rhodocyclales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese CMS2_k127_6236726_11 387093.SUN_1857 7.489e-88 312.0 COG0784@1|root,COG2202@1|root,COG3287@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3287@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2YTEC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Two-component sensor histidine kinase response regulator - - - - - - - - - - - - FIST,FIST_C,HATPase_c,HisKA,Response_reg CMS2_k127_6236726_9 1172190.M947_01220 1.814e-94 316.0 COG1092@1|root,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria,42Q87@68525|delta/epsilon subdivisions,2YNGM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Belongs to the methyltransferase superfamily - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM CMS2_k127_6261334_0 563040.Saut_1599 0.0 1237.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2YMHZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C CMS2_k127_6261334_13 1408442.JADE01000003_gene633 2.363e-22 101.0 COG1959@1|root,COG1959@2|Bacteria,1PC6Q@1224|Proteobacteria,42VG6@68525|delta/epsilon subdivisions,2YQBX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 CMS2_k127_6261334_6 709032.Sulku_0678 8.488e-68 234.0 COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,42UCT@68525|delta/epsilon subdivisions,2YRMZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides - - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N CMS2_k127_6261334_11 563040.Saut_1601 7.929e-33 131.0 2BQIT@1|root,32JEK@2|Bacteria,1Q29V@1224|Proteobacteria,42V8T@68525|delta/epsilon subdivisions,2YQEB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6261334_7 929558.SMGD1_1904 4.219e-57 206.0 29VYJ@1|root,30HGQ@2|Bacteria,1Q33E@1224|Proteobacteria,42WQE@68525|delta/epsilon subdivisions,2YQMM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6261334_5 572480.Arnit_1180 5.048e-72 247.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RJP@68525|delta/epsilon subdivisions,2YP82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COG1881 Phospholipid-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP CMS2_k127_6261334_9 316067.Geob_3737 2.037e-42 164.0 COG3809@1|root,COG3809@2|Bacteria,1P0JI@1224|Proteobacteria,432XD@68525|delta/epsilon subdivisions,2WY3I@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Transcription factor zinc-finger - - - - - - - - - - - - zf-TFIIB CMS2_k127_6261334_3 857087.Metme_1565 4.423e-123 403.0 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,1S1VS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S virion core protein (lumpy skin disease virus) - - - - - - - - - - - - Band_7_1 CMS2_k127_6261334_8 563040.Saut_1665 8.162e-50 180.0 COG0816@1|root,COG0816@2|Bacteria,1RJ6T@1224|Proteobacteria,42UR4@68525|delta/epsilon subdivisions,2YSYJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX CMS2_k127_6261334_2 1249480.B649_02895 1.677e-187 595.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,42M6T@68525|delta/epsilon subdivisions,2YMJD@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N CMS2_k127_6261334_4 929558.SMGD1_1901 2.218e-86 296.0 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QYV@68525|delta/epsilon subdivisions,2YNW5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Jag_N - - - ko:K06346 - - - - ko00000 - - - Jag_N CMS2_k127_6261334_1 1537917.JU82_03180 1.382e-198 631.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2YMUQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas CMS2_k127_6261334_10 326298.Suden_0523 4.341e-39 150.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,42VNC@68525|delta/epsilon subdivisions,2YQ9K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane - - - - - - - - - - - - Haemolytic CMS2_k127_6261334_12 1249480.B649_02875 1.268e-23 103.0 COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,42U9K@68525|delta/epsilon subdivisions,2YQ3Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P CMS2_k127_6261334_14 563040.Saut_1670 6.388e-17 80.0 COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,42WSU@68525|delta/epsilon subdivisions,2YQ70@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 CMS2_k127_6346752_1 1121451.DESAM_21683 1.872e-208 663.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M9AP@213115|Desulfovibrionales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran CMS2_k127_6346752_4 273121.WS0413 2.452e-56 212.0 COG1538@1|root,COG1538@2|Bacteria,1Q54T@1224|Proteobacteria,42U8P@68525|delta/epsilon subdivisions,2YQ0E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP CMS2_k127_6346752_7 1122201.AUAZ01000018_gene1698 2.174e-13 75.0 2E5B0@1|root,33033@2|Bacteria,1ND0X@1224|Proteobacteria,1SEBX@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6346752_2 1165841.SULAR_03183 5.034e-124 412.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,42P0P@68525|delta/epsilon subdivisions,2YN3S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Na H antiporter nhaC - - - - - - - - - - - Na_H_antiporter CMS2_k127_6346752_5 1249480.B649_10425 8.223e-56 201.0 COG0454@1|root,COG0456@2|Bacteria,1N3WW@1224|Proteobacteria,42XJV@68525|delta/epsilon subdivisions,2YRW0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K acetyltransferase - - - - - - - - - - - - - CMS2_k127_6346752_6 326298.Suden_1793 2.008e-51 190.0 COG3786@1|root,COG3786@2|Bacteria,1RH22@1224|Proteobacteria,42U32@68525|delta/epsilon subdivisions,2YPTI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S COGs COG3786 conserved - - - - - - - - - - - - YkuD CMS2_k127_6346752_3 1249480.B649_00335 5.309e-114 386.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42Q5F@68525|delta/epsilon subdivisions,2YPMR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Cache_3-Cache_2,MCPsignal CMS2_k127_6346752_0 563040.Saut_0376 8.665e-274 860.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2YNGB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member recD - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2,Viral_helicase1 CMS2_k127_6349652_1 1165841.SULAR_01928 6.225e-178 561.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2YNRG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M COG2230 Cyclopropane fatty acid synthase and related cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS CMS2_k127_6349652_2 1165841.SULAR_01933 1.161e-96 317.0 2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,42ZFJ@68525|delta/epsilon subdivisions,2YRR8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3833) - - - - - - - - - - - - DUF3833 CMS2_k127_6349652_0 1165841.SULAR_01958 1.165e-216 682.0 COG1233@1|root,COG1233@2|Bacteria,1P0N4@1224|Proteobacteria,42NRZ@68525|delta/epsilon subdivisions,2YMGH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 CMS2_k127_6391747_16 1165841.SULAR_01175 2.5e-83 281.0 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,42TZV@68525|delta/epsilon subdivisions,2YR1J@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Phospholipase/Carboxylesterase - - - - - - - - - - - - Abhydrolase_2 CMS2_k127_6391747_28 1172190.M947_02475 7.4e-30 119.0 COG0828@1|root,COG0828@2|Bacteria,1Q61C@1224|Proteobacteria,42VSR@68525|delta/epsilon subdivisions,2YQAH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 CMS2_k127_6391747_27 572480.Arnit_1444 3.596e-31 124.0 COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,42VGM@68525|delta/epsilon subdivisions,2YQ7S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L endonuclease containing a URI domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG CMS2_k127_6391747_24 944547.ABLL_1646 8.281e-45 177.0 COG0715@1|root,COG0834@1|root,COG2199@1|root,COG0715@2|Bacteria,COG0834@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42MCD@68525|delta/epsilon subdivisions,2YN6K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria ET Diguanylate cyclase - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - GGDEF,NMT1,SBP_bac_3 CMS2_k127_6391747_18 1249480.B649_05560 9.301e-77 261.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2YNXC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iIT341.HP0618 ADK CMS2_k127_6391747_1 563040.Saut_1194 5e-323 995.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2YMJV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon CMS2_k127_6391747_22 387092.NIS_0044 9.552e-54 192.0 COG4802@1|root,COG4802@2|Bacteria,1QYD3@1224|Proteobacteria,42PN1@68525|delta/epsilon subdivisions,2YMYE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria CP PFAM Ferredoxin thioredoxin reductase catalytic beta chain - - - - - - - - - - - - FeThRed_B,Rhodanese CMS2_k127_6391747_9 709032.Sulku_1436 2.531e-129 418.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2YNDC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase CMS2_k127_6391747_5 326298.Suden_1084 8.369e-159 515.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2YN1V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N CMS2_k127_6391747_12 709032.Sulku_1434 1.584e-103 342.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2YMA2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L hydrolase, TatD tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase CMS2_k127_6391747_6 1172190.M947_00615 3.017e-155 499.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2YM7M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M lytic murein transglycosylase mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT CMS2_k127_6391747_15 1172190.M947_00610 1.132e-86 293.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2YMTU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR CMS2_k127_6391747_14 709032.Sulku_1431 1.094e-89 298.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2YN3P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Imidazoleglycerol-phosphate dehydratase hisB - 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD,PNK3P CMS2_k127_6391747_21 1355374.JARU01000003_gene1177 3.429e-58 206.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2YPEC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 CMS2_k127_6391747_25 563040.Saut_1146 6.924e-42 159.0 COG1934@1|root,COG1934@2|Bacteria,1NJS7@1224|Proteobacteria,42SEJ@68525|delta/epsilon subdivisions,2YPFN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Lipopolysaccharide transport periplasmic protein lpta lptA - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA CMS2_k127_6391747_17 1537917.JU82_08155 1.546e-78 267.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,42RJR@68525|delta/epsilon subdivisions,2YP3U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 CMS2_k127_6391747_20 709032.Sulku_1426 1.616e-61 215.0 COG1246@1|root,COG1246@2|Bacteria,1RHT7@1224|Proteobacteria,42SGE@68525|delta/epsilon subdivisions,2YPNW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E acetyltransferase - - 2.3.1.1 ko:K00619 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 CMS2_k127_6391747_2 1172190.M947_00570 4.471e-248 779.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2YMEF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M penicillin-binding protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase CMS2_k127_6391747_8 563040.Saut_1141 4.004e-139 449.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,42Q58@68525|delta/epsilon subdivisions,2YNDQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P K -dependent Na Ca exchanger - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex CMS2_k127_6391747_23 563040.Saut_1140 1.533e-46 171.0 COG0319@1|root,COG0319@2|Bacteria,1Q9G0@1224|Proteobacteria,42SJD@68525|delta/epsilon subdivisions,2YPJA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 CMS2_k127_6391747_29 323850.Shew_2983 1.14e-29 125.0 2CJ51@1|root,32S98@2|Bacteria,1N0AX@1224|Proteobacteria,1SAGU@1236|Gammaproteobacteria,2QBZS@267890|Shewanellaceae 1236|Gammaproteobacteria S Gluconate 2-dehydrogenase subunit 3 - - 1.1.99.3 ko:K06152 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - Gluconate_2-dh3 CMS2_k127_6391747_3 1535422.ND16A_3437 1.089e-232 732.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,2Q6A8@267889|Colwelliaceae 1236|Gammaproteobacteria E GMC oxidoreductase - - 1.1.99.3 ko:K06151 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 CMS2_k127_6391747_11 563040.Saut_1138 6.211e-111 363.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2YMGA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC CMS2_k127_6391747_30 1165841.SULAR_08060 3.24e-28 122.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,42V1Y@68525|delta/epsilon subdivisions,2YQ5Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Metal-dependent hydrolase - - - ko:K07043 - - - - ko00000 - - - DUF45,WLM CMS2_k127_6391747_10 929558.SMGD1_2687 1.601e-119 397.0 COG1306@1|root,COG1306@2|Bacteria,1MWBY@1224|Proteobacteria,42NSR@68525|delta/epsilon subdivisions,2YP0V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Putative glycosyl hydrolase domain - - - - - - - - - - - - DUF4015 CMS2_k127_6391747_19 1122194.AUHU01000007_gene286 1.42e-72 253.0 COG1876@1|root,COG1876@2|Bacteria,1RB64@1224|Proteobacteria,1RRSM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - VanY CMS2_k127_6391747_26 1537915.JU57_09895 7.277e-38 152.0 COG2199@1|root,COG2199@2|Bacteria,1Q2N5@1224|Proteobacteria,42VZ7@68525|delta/epsilon subdivisions,2YQIC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T COG2199 FOG GGDEF domain - - - - - - - - - - - - GGDEF CMS2_k127_6391747_4 929558.SMGD1_2686 4.301e-172 547.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,42NEN@68525|delta/epsilon subdivisions,2YN4D@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP CMS2_k127_6391747_13 929558.SMGD1_2676 1.102e-93 317.0 COG0770@1|root,COG0770@2|Bacteria,1Q5GZ@1224|Proteobacteria,42RQ8@68525|delta/epsilon subdivisions,2YP4M@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity - - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - - CMS2_k127_6391747_0 563040.Saut_1133 0.0 1043.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2YMYX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g,tRNA_bind CMS2_k127_6391747_32 182217.HCW_01025 2.905e-15 77.0 2AK4P@1|root,31AUI@2|Bacteria,1Q664@1224|Proteobacteria,42X10@68525|delta/epsilon subdivisions,2YQR8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6391747_7 709032.Sulku_1411 1.668e-139 447.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,42NRA@68525|delta/epsilon subdivisions,2YMJC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase CMS2_k127_6392429_12 572480.Arnit_1753 1.559e-18 88.0 COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,42PG2@68525|delta/epsilon subdivisions,2YMDE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S A blastn search against coding sequences extracted from AL111168.1, CP000025.1, CP000538.1, CP000768.1, CP000814.1 failed to identify a tssM - - ko:K11891 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - IcmF-related,IcmF_C,ImcF-related_N CMS2_k127_6392429_8 572480.Arnit_1752 2.932e-53 199.0 COG3455@1|root,COG3455@2|Bacteria,1MU13@1224|Proteobacteria,42P79@68525|delta/epsilon subdivisions,2YNRB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Type VI secretion system protein DotU tssL - - ko:K11892 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - DotU CMS2_k127_6392429_3 572480.Arnit_1751 4.21e-155 501.0 COG3522@1|root,COG3522@2|Bacteria,1MXKE@1224|Proteobacteria,42MMT@68525|delta/epsilon subdivisions,2YNT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Type VI secretion tssK - - ko:K11893 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_VasE CMS2_k127_6392429_11 572480.Arnit_1750 7.314e-43 161.0 COG3521@1|root,COG3521@2|Bacteria,1QJBT@1224|Proteobacteria,4326J@68525|delta/epsilon subdivisions 1224|Proteobacteria S Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 - - - ko:K11906 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS-SciN CMS2_k127_6392429_6 572480.Arnit_1749 7.613e-76 271.0 COG1716@1|root,COG3456@1|root,COG1716@2|Bacteria,COG3456@2|Bacteria,1R9YP@1224|Proteobacteria 1224|Proteobacteria T conserved protein, contains FHA domain - - - ko:K11894 - - - - ko00000,ko02044 3.A.23.1 - - FHA CMS2_k127_6392429_0 1355368.JART01000030_gene1643 1.573e-307 966.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,42PEV@68525|delta/epsilon subdivisions,2YRKH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O C-terminal, D2-small domain, of ClpB protein - - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small CMS2_k127_6392429_4 572480.Arnit_1746 4.15e-103 344.0 COG3520@1|root,COG3520@2|Bacteria,1NHB5@1224|Proteobacteria,43BEP@68525|delta/epsilon subdivisions,2YT82@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Type VI secretion, TssG - - - ko:K11895 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_TssG CMS2_k127_6392429_2 572480.Arnit_1745 6.062e-215 682.0 COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,42PZ8@68525|delta/epsilon subdivisions,2YNUC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Type VI secretion vasA - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF CMS2_k127_6392429_9 572480.Arnit_1744 1.256e-43 164.0 COG3518@1|root,COG3518@2|Bacteria,1N885@1224|Proteobacteria,42WTJ@68525|delta/epsilon subdivisions 1224|Proteobacteria S TIGRFAM Type VI secretion system, lysozyme-related tssE2 - - ko:K11905 - M00334 - - ko00000,ko00002,ko02044 - - - GPW_gp25 CMS2_k127_6392429_1 572480.Arnit_1743 1.488e-270 838.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,42M4A@68525|delta/epsilon subdivisions,2YNDF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S type VI secretion protein tssC - - ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB CMS2_k127_6392429_7 572480.Arnit_1742 1.037e-62 219.0 COG3516@1|root,COG3516@2|Bacteria,1RBNB@1224|Proteobacteria,42S55@68525|delta/epsilon subdivisions,2YP5H@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Type VI secretion tssB - - ko:K11901 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_VipA CMS2_k127_6392429_5 572480.Arnit_1741 1.461e-88 310.0 COG3515@1|root,COG3515@2|Bacteria,1RC37@1224|Proteobacteria,43ACE@68525|delta/epsilon subdivisions 1224|Proteobacteria S Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ - - - ko:K11910 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - ImpA_N,T6SS_VasJ CMS2_k127_6415002_1 1280941.HY2_16785 6.682e-37 142.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2963 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 CMS2_k127_6415002_0 883078.HMPREF9695_00440 1.702e-101 338.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,3JS1E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L leucine-zipper of insertion element IS481 - - 2.7.7.49 ko:K00986,ko:K07497 - - - - ko00000,ko01000 - - - HTH_32,rve CMS2_k127_6517716_2 929558.SMGD1_2814 2.751e-91 307.0 COG1409@1|root,COG1409@2|Bacteria,1N85S@1224|Proteobacteria,42WZ6@68525|delta/epsilon subdivisions 1224|Proteobacteria G Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,Metallophos_C,PKD,Pur_ac_phosph_N CMS2_k127_6517716_0 929558.SMGD1_2852 3.368e-245 774.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,42Q3N@68525|delta/epsilon subdivisions,2YMVW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Sulfatase - - - - - - - - - - - - Sulfatase CMS2_k127_6517716_1 709032.Sulku_0307 4.09e-133 428.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2YMF2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,UPF0004 CMS2_k127_6542110_0 563040.Saut_1471 0.0 1161.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2YN92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C CMS2_k127_6579920_0 1165841.SULAR_04252 1.666e-206 647.0 COG0008@1|root,COG0064@1|root,COG0008@2|Bacteria,COG0064@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2YNBY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J PFAM tRNA synthetases class I (E and Q), catalytic domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C CMS2_k127_6579920_1 326298.Suden_1814 3.458e-32 134.0 COG4783@1|root,COG4783@2|Bacteria,1QZ2M@1224|Proteobacteria,43CEP@68525|delta/epsilon subdivisions,2YTC5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S chaperone-mediated protein folding - - - - - - - - - - - - - CMS2_k127_6599485_4 387092.NIS_0379 1.76e-20 93.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2YPT8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS CMS2_k127_6599485_0 1123326.JFBL01000012_gene107 1.306e-125 407.0 COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,42QAW@68525|delta/epsilon subdivisions,2YNQK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Belongs to the ParA family minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA CMS2_k127_6599485_3 1537915.JU57_05615 5.91e-21 94.0 COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,42X0P@68525|delta/epsilon subdivisions,2YQXU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE CMS2_k127_6599485_1 1172190.M947_03445 1.127e-83 288.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,42RJN@68525|delta/epsilon subdivisions,2YP6V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Divergent polysaccharide deacetylase - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 CMS2_k127_6599485_2 387093.SUN_0445 1.109e-69 243.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2YMIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LU DNA processing protein dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A CMS2_k127_6627570_11 929558.SMGD1_1317 5.817e-33 131.0 COG1547@1|root,COG1547@2|Bacteria,1PD94@1224|Proteobacteria,42WUE@68525|delta/epsilon subdivisions,2YQXY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function (DUF309) - - - - - - - - - - - - DUF309 CMS2_k127_6627570_10 1172190.M947_07990 7.373e-44 162.0 COG0607@1|root,COG0607@2|Bacteria,1Q1NN@1224|Proteobacteria,42U2F@68525|delta/epsilon subdivisions,2YQ1E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - CMS2_k127_6627570_0 1249480.B649_00210 3.139e-280 889.0 COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,42PR3@68525|delta/epsilon subdivisions,2YN2Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Mitochondrial degradasome RNA helicase subunit C terminal - - 3.6.4.13 ko:K17675 - - - - ko00000,ko01000,ko03029 - - - Helicase_C,SUV3_C CMS2_k127_6627570_9 1249480.B649_00200 2.195e-49 183.0 2AIM2@1|root,319HK@2|Bacteria,1Q2ST@1224|Proteobacteria,42W74@68525|delta/epsilon subdivisions,2YQAM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6627570_16 1249480.B649_00195 2.091e-09 60.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42PGR@68525|delta/epsilon subdivisions,2YRIC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM metal-dependent phosphohydrolase HD sub domain - - - - - - - - - - - - HD CMS2_k127_6627570_14 709032.Sulku_0068 4.013e-13 72.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42PGR@68525|delta/epsilon subdivisions,2YRIC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T PFAM metal-dependent phosphohydrolase HD sub domain - - - - - - - - - - - - HD,HD_5 CMS2_k127_6627570_8 1172190.M947_02375 2.047e-63 221.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,42SVZ@68525|delta/epsilon subdivisions,2YPE3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 CMS2_k127_6627570_4 709032.Sulku_1906 4.608e-198 635.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42SS2@68525|delta/epsilon subdivisions,2YRAM@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT chemotaxis protein - - - - - - - - - - - - CZB,MCPsignal CMS2_k127_6627570_7 929558.SMGD1_1298 7.555e-95 316.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42R1M@68525|delta/epsilon subdivisions,2YNZ3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, iron-sulfur protein - - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 CMS2_k127_6627570_2 929558.SMGD1_1297 1.022e-215 682.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C CMS2_k127_6627570_12 1172190.M947_02400 2.673e-32 130.0 COG1238@1|root,COG1238@2|Bacteria 2|Bacteria I metal cluster binding yqaA - - - - - - - - - - - SNARE_assoc CMS2_k127_6627570_6 709032.Sulku_0075 6.751e-135 436.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,42M8N@68525|delta/epsilon subdivisions,2YMFN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family hprA - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C CMS2_k127_6627570_3 929558.SMGD1_1290 3.626e-208 651.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,42MYW@68525|delta/epsilon subdivisions,2YN5Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp CMS2_k127_6627570_15 362418.IW19_11665 1.119e-11 76.0 COG0793@1|root,COG0793@2|Bacteria,4NEF4@976|Bacteroidetes,1HZ1M@117743|Flavobacteriia,2NTFB@237|Flavobacterium 976|Bacteroidetes M Domain present in PSD-95, Dlg, and ZO-1/2. - - - - - - - - - - - - Asp_protease_2,PDZ,PDZ_2 CMS2_k127_6627570_5 1537917.JU82_03925 1.205e-190 612.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42MBE@68525|delta/epsilon subdivisions,2YNGN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein - - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran CMS2_k127_6627570_1 563040.Saut_0036 2.962e-228 718.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2YMJR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaGprimase_HBD,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 CMS2_k127_6627570_13 1249480.B649_00135 1.022e-30 127.0 2AIZZ@1|root,319I0@2|Bacteria,1Q2U7@1224|Proteobacteria,42W9A@68525|delta/epsilon subdivisions,2YQB5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6628449_1 1249480.B649_06585 3.643e-80 270.0 COG0454@1|root,COG0456@2|Bacteria,1Q9FS@1224|Proteobacteria,42YQT@68525|delta/epsilon subdivisions,2YRH5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_10 CMS2_k127_6628449_4 387093.SUN_0804 1.045e-08 59.0 COG1918@1|root,COG1918@2|Bacteria,1Q53C@1224|Proteobacteria,42X0A@68525|delta/epsilon subdivisions,2YQP0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Fe2 transport system protein A - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA CMS2_k127_6628449_3 517417.Cpar_1595 3.839e-21 93.0 2EJKX@1|root,33DBU@2|Bacteria 2|Bacteria S Rop-like - - - - - - - - - - - - Rop-like CMS2_k127_6628449_2 990073.ATHU01000001_gene1785 4.935e-31 123.0 2A433@1|root,30SN2@2|Bacteria,1PBWY@1224|Proteobacteria,42VT4@68525|delta/epsilon subdivisions,2YQB2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_6628449_0 990073.ATHU01000001_gene1786 1.42e-93 319.0 COG0454@1|root,COG4886@1|root,COG0456@2|Bacteria,COG4886@2|Bacteria,1Q94S@1224|Proteobacteria,42X59@68525|delta/epsilon subdivisions,2YQUI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KLT COG4886 Leucine-rich repeat (LRR) protein - - - - - - - - - - - - LRR_4,LRR_8,Pkinase CMS2_k127_6757094_0 929558.SMGD1_1335 1.243e-141 459.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,42M9K@68525|delta/epsilon subdivisions,2YR2K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - CbiA,GATase_3 CMS2_k127_6757094_1 326298.Suden_0112 1.198e-54 196.0 COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,42TUT@68525|delta/epsilon subdivisions,2YQ2Y@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H PFAM Cobinamide kinase cobinamide phosphate guanyltransferase cobP - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU CMS2_k127_682367_4 709032.Sulku_1411 1.771e-06 49.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,42NRA@68525|delta/epsilon subdivisions,2YMJC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase CMS2_k127_682367_2 929558.SMGD1_2672 1.233e-70 242.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2YPCQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H molybdopterin-guanine dinucleotide biosynthesis protein mobB - - ko:K03753 - - - - ko00000 - - - MobB CMS2_k127_682367_0 929558.SMGD1_2671 2.445e-129 432.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,42N7A@68525|delta/epsilon subdivisions,2YMRE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M lytic murein transglycosylase slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT CMS2_k127_682367_3 326298.Suden_1060 2.373e-27 114.0 COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2YQ8B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT CMS2_k127_682367_1 326298.Suden_1059 1.185e-106 349.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42NHA@68525|delta/epsilon subdivisions,2YMYU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX1 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c CMS2_k127_69070_0 1123326.JFBL01000001_gene1268 1.04e-57 203.0 COG1145@1|root,COG1145@2|Bacteria,1QZ2K@1224|Proteobacteria,42SFI@68525|delta/epsilon subdivisions,2YPQC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7 CMS2_k127_69070_2 1249480.B649_06750 2.158e-35 138.0 COG1433@1|root,COG1433@2|Bacteria,1N05Z@1224|Proteobacteria,42VFK@68525|delta/epsilon subdivisions,2YQG3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Dinitrogenase iron-molybdenum cofactor biosynthesis protein - - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co CMS2_k127_69070_1 709032.Sulku_1094 1.259e-43 160.0 COG2768@1|root,COG2768@2|Bacteria,1R1K0@1224|Proteobacteria,43DAC@68525|delta/epsilon subdivisions,2YTHE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7,Fer4_9 CMS2_k127_6941735_1 563040.Saut_1607 3.493e-210 656.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2YMAA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C CMS2_k127_6941735_4 326298.Suden_1638 2.775e-70 242.0 COG1040@1|root,COG1040@2|Bacteria,1Q1C2@1224|Proteobacteria,42T93@68525|delta/epsilon subdivisions,2YPEB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S transformation system protein ctsW - - ko:K02242 - M00429 - - ko00000,ko00002,ko02044 - - - Pribosyltran CMS2_k127_6941735_7 1122917.KB899663_gene2512 3.261e-08 65.0 COG1196@1|root,COG3291@1|root,COG5492@1|root,COG1196@2|Bacteria,COG3291@2|Bacteria,COG5492@2|Bacteria,1VQF9@1239|Firmicutes,4HWCW@91061|Bacilli,26WM6@186822|Paenibacillaceae 91061|Bacilli N Pkd domain containing protein xynX1 - - - - - - - - - - - DUF5011,F5_F8_type_C,SLH CMS2_k127_6941735_2 929558.SMGD1_0919 2.389e-183 587.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,42QDE@68525|delta/epsilon subdivisions,2YMPN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase CMS2_k127_6941735_3 563040.Saut_0742 1.445e-146 471.0 COG2404@1|root,COG2404@2|Bacteria,1NHB1@1224|Proteobacteria,42NB0@68525|delta/epsilon subdivisions,2YMQ4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S phosphohydrolase (DHH superfamily) - - - ko:K07097 - - - - ko00000 - - - DHHA1 CMS2_k127_6941735_0 1172190.M947_02325 0.0 1054.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,42NB2@68525|delta/epsilon subdivisions,2YMVN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP CMS2_k127_6941735_5 929558.SMGD1_0390 1.39e-44 166.0 COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SJM@68525|delta/epsilon subdivisions,2YPJG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 CMS2_k127_6941735_6 326298.Suden_0726 5.294e-31 125.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2YPU9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 CMS2_k127_6990931_0 563040.Saut_1739 7.289e-104 347.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2YNID@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S acid membrane antigen A amaA - - - - - - - - - - - AI-2E_transport CMS2_k127_7089420_2 1172190.M947_01190 2.305e-107 361.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42WJ0@68525|delta/epsilon subdivisions,2YQJR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P PFAM TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec CMS2_k127_7089420_5 929558.SMGD1_2768 4.513e-42 161.0 COG3916@1|root,COG3916@2|Bacteria 2|Bacteria QT Acyl-homoserine-lactone synthase - - - - - - - - - - - - Acetyltransf_5 CMS2_k127_7089420_0 929558.SMGD1_1137 4.356e-289 899.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2YN8I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Abc transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn CMS2_k127_7089420_7 1249480.B649_04410 2.834e-24 113.0 COG1187@1|root,COG1187@2|Bacteria,1QZ1N@1224|Proteobacteria,430HW@68525|delta/epsilon subdivisions,2YS1F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J pseudouridine synthase activity - - - - - - - - - - - - - CMS2_k127_7089420_8 1172190.M947_00300 5.945e-22 99.0 2AJSI@1|root,31AEV@2|Bacteria,1Q5GJ@1224|Proteobacteria,4317Q@68525|delta/epsilon subdivisions,2YS8K@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_7089420_1 929558.SMGD1_1328 9.684e-234 747.0 COG0834@1|root,COG2206@1|root,COG3437@1|root,COG0834@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,42N4N@68525|delta/epsilon subdivisions,2YNIK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT HD domain - - - - - - - - - - - - HD_5,dCache_1 CMS2_k127_7089420_3 709032.Sulku_0538 3.546e-86 291.0 COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42UAU@68525|delta/epsilon subdivisions,2YNG0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 CMS2_k127_7089420_6 324925.Ppha_1619 1.631e-26 112.0 COG4628@1|root,COG4628@2|Bacteria 2|Bacteria S conserved protein (DUF2132) YPO1157 - - - - - - - - - - - VF530 CMS2_k127_7089420_4 754476.Q7A_83 1.821e-72 250.0 COG1944@1|root,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,1RN47@1236|Gammaproteobacteria,45ZWA@72273|Thiotrichales 72273|Thiotrichales O YcaO cyclodehydratase, ATP-ad Mg2+-binding - - - ko:K09136 - - - - ko00000,ko03009 - - - YcaO CMS2_k127_7093059_1 944547.ABLL_2330 1.129e-100 346.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2YNRH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU general secretion pathway protein D - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N CMS2_k127_7093059_0 944547.ABLL_2329 6.528e-182 582.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2YMIX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE CMS2_k127_7093059_2 598659.NAMH_0017 0.0001275 51.0 2BSET@1|root,32MGT@2|Bacteria,1Q39R@1224|Proteobacteria,42WZN@68525|delta/epsilon subdivisions,2YQU4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl CMS2_k127_75006_13 1123326.JFBL01000018_gene2372 2.094e-83 283.0 COG2733@1|root,COG2733@2|Bacteria,1R4JT@1224|Proteobacteria,42RK1@68525|delta/epsilon subdivisions,2YPBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - CMS2_k127_75006_19 1437425.CSEC_0203 9.188e-32 129.0 COG2259@1|root,COG2259@2|Bacteria,2JGJ1@204428|Chlamydiae 204428|Chlamydiae S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX CMS2_k127_75006_6 709032.Sulku_0568 1.247e-141 462.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42M1K@68525|delta/epsilon subdivisions,2YMKR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the peptidase M24B family pepQ - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C CMS2_k127_75006_9 563040.Saut_1539 8.982e-112 365.0 COG0745@1|root,COG0745@2|Bacteria,1PGAE@1224|Proteobacteria,4348Y@68525|delta/epsilon subdivisions,2YREY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C CMS2_k127_75006_4 326298.Suden_0617 5.429e-247 790.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42Z31@68525|delta/epsilon subdivisions,2YRAR@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Hpt sensor hybrid histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg CMS2_k127_75006_5 1249480.B649_08130 2.752e-168 551.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42UBD@68525|delta/epsilon subdivisions,2YRGP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T 7TM diverse intracellular signalling - - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c CMS2_k127_75006_21 709032.Sulku_2374 5.813e-28 115.0 COG2841@1|root,COG2841@2|Bacteria,1NGDM@1224|Proteobacteria,42V3Q@68525|delta/epsilon subdivisions,2YQ8Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF465) - - - ko:K09794 - - - - ko00000 - - - DUF465 CMS2_k127_75006_20 1249480.B649_07970 1.307e-30 123.0 COG4627@1|root,COG4627@2|Bacteria,1NHR6@1224|Proteobacteria,42VA4@68525|delta/epsilon subdivisions,2YQEV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Stress responsive A B Barrel Domain - - - - - - - - - - - - Dabb CMS2_k127_75006_7 709032.Sulku_2649 1.122e-140 459.0 COG1538@1|root,COG1538@2|Bacteria,1QWWG@1224|Proteobacteria,42PH5@68525|delta/epsilon subdivisions,2YMHH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria MU outer membrane efflux protein - - - - - - - - - - - - OEP CMS2_k127_75006_10 563040.Saut_1332 1.262e-101 340.0 COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2YN1Q@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 CMS2_k127_75006_3 709032.Sulku_0906 1.176e-251 784.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2YN57@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran CMS2_k127_75006_2 709032.Sulku_0905 2.024e-256 801.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MA6@68525|delta/epsilon subdivisions,2YMMG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V COG0841 Cation multidrug efflux pump - - - - - - - - - - - - ACR_tran CMS2_k127_75006_0 862908.BMS_1212 3.479e-310 972.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2MSTB@213481|Bdellovibrionales,2WJ2C@28221|Deltaproteobacteria 213481|Bdellovibrionales E Peptidase M1 membrane alanine aminopeptidase pepN - 3.4.11.2 ko:K01256,ko:K08776 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,ERAP1_C,HEAT_2,Peptidase_M1 CMS2_k127_75006_18 1007105.PT7_3010 3.007e-38 149.0 COG3613@1|root,COG3613@2|Bacteria,1N0AK@1224|Proteobacteria,2VRQT@28216|Betaproteobacteria,3T3T0@506|Alcaligenaceae 28216|Betaproteobacteria F Nucleoside 2-deoxyribosyltransferase - - 2.4.2.6 ko:K08728 ko00240,map00240 - R02806 RC00063 ko00000,ko00001,ko01000 - - - Nuc_deoxyrib_tr CMS2_k127_75006_17 709032.Sulku_0692 3.337e-40 153.0 COG2010@1|root,COG2010@2|Bacteria,1QZ1X@1224|Proteobacteria,42WCS@68525|delta/epsilon subdivisions,2YQIG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C CMS2_k127_75006_12 1249480.B649_09465 4.67e-92 316.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,42MIH@68525|delta/epsilon subdivisions 1224|Proteobacteria T PFAM EAL domain protein - - - - - - - - - - - - EAL,HDOD CMS2_k127_75006_14 929558.SMGD1_0735 1.011e-76 263.0 COG4508@1|root,COG4508@2|Bacteria,1RAX1@1224|Proteobacteria,42MG5@68525|delta/epsilon subdivisions,2YN7I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM dUTPase dut - - - - - - - - - - - dUTPase_2 CMS2_k127_75006_23 944546.ABED_1206 2.011e-19 89.0 2EH2E@1|root,33AUC@2|Bacteria,1NI43@1224|Proteobacteria,42WYJ@68525|delta/epsilon subdivisions,2YQNV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_75006_22 1203611.KB894542_gene682 4.512e-21 99.0 COG3787@1|root,COG3787@2|Bacteria,4NSSF@976|Bacteroidetes,2FYET@200643|Bacteroidia,22UJ9@171550|Rikenellaceae 976|Bacteroidetes S Pyridoxamine 5'-phosphate oxidase - - - ko:K09979 - - - - ko00000 - - - Putative_PNPOx CMS2_k127_75006_16 1121396.KB892941_gene3923 2.353e-64 231.0 COG1397@1|root,COG1397@2|Bacteria,1RA82@1224|Proteobacteria,42QPD@68525|delta/epsilon subdivisions,2WMNN@28221|Deltaproteobacteria,2MJI9@213118|Desulfobacterales 28221|Deltaproteobacteria O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH CMS2_k127_75006_11 1165841.SULAR_03842 4.007e-100 331.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42SWD@68525|delta/epsilon subdivisions,2YP1S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 CMS2_k127_75006_8 521045.Kole_0146 7.688e-128 419.0 COG1168@1|root,COG1168@2|Bacteria,2GCM9@200918|Thermotogae 200918|Thermotogae E aminotransferase class I and II - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Acetyltransf_10,Aminotran_1_2 CMS2_k127_75006_1 929558.SMGD1_0740 1.591e-292 913.0 COG1262@1|root,COG1352@1|root,COG1262@2|Bacteria,COG1352@2|Bacteria,1MUNC@1224|Proteobacteria,42N4Y@68525|delta/epsilon subdivisions,2YNCE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria NT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - DinB_2,FGE-sulfatase,Methyltransf_11,Methyltransf_31 CMS2_k127_75006_15 1249480.B649_09135 1.1e-71 250.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2YPMA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 CMS2_k127_75006_26 1122986.KB908333_gene2328 7.796e-05 47.0 2CA5P@1|root,2ZWDW@2|Bacteria,4P8RE@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - CMS2_k127_78777_1 367737.Abu_1401 6.568e-53 189.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2YMY3@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O hydrogenase expression formation protein hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C CMS2_k127_78777_2 563040.Saut_1301 1.639e-44 164.0 COG0223@1|root,COG0375@1|root,COG1024@1|root,COG0223@2|Bacteria,COG0375@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,42PAJ@68525|delta/epsilon subdivisions,2YNKB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IJ Enoyl-CoA hydratase/isomerase - - - ko:K19640 - - - - ko00000,ko02022 - - - ECH_1,Formyl_trans_C,Formyl_trans_N CMS2_k127_78777_0 387093.SUN_1214 0.0 1143.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2YMT6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N CMS2_k127_814390_8 1249480.B649_06610 8.532e-45 168.0 COG2077@1|root,COG2077@2|Bacteria,1Q5Y2@1224|Proteobacteria,4321Y@68525|delta/epsilon subdivisions,2YS92@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides - - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - - CMS2_k127_814390_2 709032.Sulku_1514 2.165e-143 459.0 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,42Z77@68525|delta/epsilon subdivisions,2YRAX@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 CMS2_k127_814390_3 709032.Sulku_1515 7.018e-99 325.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2YMBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins - - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease CMS2_k127_814390_0 1249480.B649_06625 1.187e-223 698.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42NSY@68525|delta/epsilon subdivisions,2YNJN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP - - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX CMS2_k127_814390_1 1537917.JU82_10415 6.417e-222 691.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2YM81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Cysteine desulfurase iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 CMS2_k127_814390_6 1232437.KL662068_gene2789 9.552e-54 192.0 COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,42T7R@68525|delta/epsilon subdivisions,2WNQ2@28221|Deltaproteobacteria,2MJXR@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0066 - - - - - - - - - - - - UPF0066 CMS2_k127_814390_10 1304883.KI912532_gene2319 1.148e-28 117.0 2CHW3@1|root,32S6N@2|Bacteria,1N0I3@1224|Proteobacteria,2VW65@28216|Betaproteobacteria,2KXB8@206389|Rhodocyclales 206389|Rhodocyclales S Pathogenicity locus - - - - - - - - - - - - Cdd1 CMS2_k127_814390_5 709032.Sulku_1542 1.857e-58 208.0 297UU@1|root,2ZV1D@2|Bacteria,1MXFE@1224|Proteobacteria,430YU@68525|delta/epsilon subdivisions,2YS1X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - CMS2_k127_814390_7 717231.Flexsi_2157 3.131e-51 188.0 COG1528@1|root,COG1528@2|Bacteria,2GFDZ@200930|Deferribacteres 200930|Deferribacteres C Iron-storage protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin CMS2_k127_814390_4 1249480.B649_06745 6.747e-66 226.0 COG1145@1|root,COG1145@2|Bacteria,1Q4YJ@1224|Proteobacteria,4305G@68525|delta/epsilon subdivisions,2YRVT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7 CMS2_k127_814390_9 990073.ATHU01000001_gene1770 3.737e-30 120.0 COG2768@1|root,COG2768@2|Bacteria,1R1K0@1224|Proteobacteria,43DAC@68525|delta/epsilon subdivisions,2YTHE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7,Fer4_9 CMS2_k127_818341_5 563040.Saut_0407 3.606e-62 216.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2YMHI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d CMS2_k127_818341_7 1172190.M947_04300 9.013e-20 91.0 COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,42VNG@68525|delta/epsilon subdivisions,2YQ9F@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 CMS2_k127_818341_2 709032.Sulku_0241 9.672e-91 302.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,42R4H@68525|delta/epsilon subdivisions,2YNWA@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0321 Guanylate_kin CMS2_k127_818341_6 929558.SMGD1_1719 1.779e-44 184.0 COG0745@1|root,COG0745@2|Bacteria,1QXJT@1224|Proteobacteria,42V47@68525|delta/epsilon subdivisions,2YQ8S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria KT RESPONSE REGULATOR receiver - - - ko:K07288 - - - - ko00000 - - - - CMS2_k127_818341_4 929558.SMGD1_1718 2.416e-85 289.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,42NX7@68525|delta/epsilon subdivisions,2YMKE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar biosynthetic protein fliR fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 CMS2_k127_818341_3 1249480.B649_01020 5.238e-86 289.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42PQP@68525|delta/epsilon subdivisions,2YNQ7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein ybbA - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran CMS2_k127_818341_0 1172190.M947_04270 1.799e-146 471.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2YMQW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS CMS2_k127_818341_1 1249480.B649_01010 3.815e-119 389.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2YMD5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 CMS2_k127_818341_8 929558.SMGD1_1707 9.622e-07 53.0 2C99Z@1|root,2Z9YV@2|Bacteria,1N0B7@1224|Proteobacteria,42P3M@68525|delta/epsilon subdivisions,2YMWY@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Protein of unknown function (DUF3373) - - - - - - - - - - - - DUF3373 CMS2_k127_95020_1 1165841.SULAR_03717 1.878e-103 339.0 COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,42RDD@68525|delta/epsilon subdivisions,2YSXC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G KDPG and KHG aldolase eda - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase CMS2_k127_95020_0 1165841.SULAR_03722 0.0 1039.0 COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,42P5S@68525|delta/epsilon subdivisions,2YNR9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EG Belongs to the IlvD Edd family edd - 4.2.1.12 ko:K01690 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00008 R02036 RC00543 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD CMS2_k127_95020_2 1165841.SULAR_03727 1.072e-98 327.0 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,42RW5@68525|delta/epsilon subdivisions,2YT3G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso CMS2_k127_95020_3 639283.Snov_3398 0.0002223 43.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria,3EXYM@335928|Xanthobacteraceae 28211|Alphaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N CMS2_k127_95378_6 1096769.Pelub83DRAFT_1400 6.485e-27 120.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria,4BQ91@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O FeS assembly protein SufD sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 CMS2_k127_95378_1 1123326.JFBL01000018_gene2362 8.332e-133 434.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PYA@68525|delta/epsilon subdivisions,2YRG0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 CMS2_k127_95378_3 1392489.JPOL01000002_gene1497 1.504e-36 145.0 COG2166@1|root,COG2166@2|Bacteria,4NM9N@976|Bacteroidetes,1I187@117743|Flavobacteriia,2XJ75@283735|Leeuwenhoekiella 976|Bacteroidetes S Fe-S metabolism associated domain sufE - - ko:K02426 - - - - ko00000 - - - SufE CMS2_k127_95378_5 765912.Thimo_2213 7.311e-29 119.0 COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S619@1236|Gammaproteobacteria,1X278@135613|Chromatiales 135613|Chromatiales S FeS assembly SUF system protein - - - - - - - - - - - - FeS_assembly_P CMS2_k127_95378_4 563040.Saut_1237 4.271e-31 129.0 COG1514@1|root,COG1514@2|Bacteria,1Q2AV@1224|Proteobacteria,42VB6@68525|delta/epsilon subdivisions,2YQIV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J 2'-5' RNA ligase - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase CMS2_k127_95378_2 1537915.JU57_09300 6.86e-90 303.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2YNS0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo CMS2_k127_95378_0 760154.Sulba_0046 4.32e-145 465.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2YNC5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM ## 2677 queries scanned ## Total time (seconds): 31.809401988983154 ## Rate: 84.16 q/s